jimnoneill/paper-to-field-training huggingface dataset:
Complete resolution of Zoon balanitis with photodynamic therapy – a new therapeutic option?

Field: Medicine (Health Sciences)

ejd.2012.1779 Auteur(s) : Teresa Pinto-almeida teresap.almeida@hotmail.com, Susana Vilaca, Isabel Amorim, Virgilio Costa, Rosario Alves, Manuela Selores Department of Dermatology, CHP – Hospital de Santo Antonio, Ex-CICAP, Rua D. Manuel II, s/n 4100 Porto, Portugal Photodynamic therapy (PDT) is approved for the treatment of actinic keratosis, Bowen's disease and basal cell carcinoma [1]. Recent advances in understanding photodynamic reactions have expanded its spectrum of action to many other [...]
A Simplified Measure of Investor Risk Aversion

Field: Economics, Econometrics and Finance (Social Sciences)

This article introduces a simplified measure of investor risk aversion. The singleitem question combines elements from revealed preference and propensity measurement techniques in a way that matches traditional constant relative risk-aversion estimation procedures. Based on survey data from 500 investors living in the United States, scores from the proposed measure were found to correlate with other measures of risk aversion, as well as with indicators of risk-taking. A validity test showed that answers to the proposed measure were statistically associated with equity and cash ownership holdings in respondent portfolios. The simplicity and intuitive nature of the proposed measure and the alignment of question response categories to estimates of constant relative risk aversion make this a potentially valuable addition to the toolkit of researchers, financial educators, investors and those who provide advice to investors. JEL: C83, D10, D11, D14, D19, D81
22nd Annual IHI Scientific Symposium on Improving the Quality and Value of Health Care

Field: Health Professions (Health Sciences)

Background Hosted by the Institute for Healthcare Improvement (IHI), the 22nd Annual Scientific Symposium on Improving the Quality and Value of Health Care takes place on Monday, December 5, 2016, in Orlando, Florida, USA. The Scientific Symposium aimed to attract high quality, scientific work, focused on the improvement of health and health care. The Symposium also aimed to foster dialog and share learning among participants. The day features keynote speakers, methods sessions, poster presentations and oral presentations. The 32 oral presentations were selected from 154 abstract submissions, through a process peer review process, that ensured each abstract was reviewed by four reviewers. For those authors that gave permission, the abstracts of the selected oral presentations are published in this supplement. Acknowledgments On behalf of the Institute for Healthcare Improvement, the hosts would like to thank the individuals whose contributions have made the 22nd Annual Scientific Symposium on Improving the Quality and Value of Health Care a success. Particular thanks are due to the abstract reviewers – Amrita Dasgupta, Anne Lambert-Kerzner, Anup Patel, Barry Appleton, Brant Oliver, David Williams, Don Goldmann, Edahrline Salas, Evie Alessandrini, Fiona Levy, Gareth Parry, Jane Roessner, Jon Finkelstein, Kedar Mate, Linson Naval, Lisa Cosimi, Lisa Rubenstien, Lloyd Provost, Mara Laderman, Marianne McPherson, Nana Twum-Danso, Natalie Henrich, Pierre Barker, Sandy Cohen, Sharon Muret-Wagstaff, A. J. Layon, Andrew Steele, Angela Green, Darren Klugman, David Mosen, Denise Remus, Ezequiel Garcia Elorrio, Jackie Valentine, Keith Mann, Mary Coleman, Omar Hasan, Rick McClead, Sandip Godambe, Thomas Bartman, Tina C. Foster, Uma Kotagal, and Wallace Crandall – without whose efforts we could not accomplish a Symposium of this quality. Thanks, as well, are due all those who were willing to submit their research for review. Last, but certainly not least, we thank our program committee members – Don Goldmann, Pierre Barker, Amy Reid, Beth McGlynn, John Finkelstein, Lisa Hirschhorn, Rohit Ramaswamy, Elizabeth McGlynn, Sabrina Selk, Rashad Massoud, Margee Louisias, Lloyd Provost, Laura Damschroder, Uma Kotagal, and Marianne McPherson – who provided valuable insight and guidance to make this year's Symposium as enriching as possible; and Amrita Dasgupta, Jason Reed and Linson Naval who have dedicated countless hours to the development of this year's program.
Jewish Leadership in Roman Palestine from 70 C.E. to 135 C.E.

Field: Arts and Humanities (Social Sciences)

Reconstructing Jewish socio-political leadership of the late Second Temple and Talmudic periods, this book suggests that the period between two great revolts is the best period to study leadership dynamics. Prior to the emergence of the rabbinic leadership, biblically modelled leadership was still a realistic option, often co-existing with non-biblical polity. It also attempts to reconstruct the Jewish socio-political leadership of this period by examining how consistently the ideas of leadership that were available before 70 C.E. were followed after 70 C.E.
Role of Incisional infiltration with intraperitoneal instillation analgesia in non descent vaginal hysterectomy

Field: Medicine (Health Sciences)

Objective: To evaluate therapeutic yield of tranexamic acid (TXA) injection and fluid co-load on the outcome of cesarean section (CS) conducted under spinal anesthesia Study Design : Prospective randomized comparative study. Patients and Methods:The current included 174 primipara scheduled for elective CS under spinal anesthesia.Intravenous (IV) fluid co-load (15 ml/kg warm lactated ringer solution) started as fast drip during and continued after spinal anesthesia.Patients were randomly allocated into two equal groups: Group TXA received a loading IV dose of 500 mg TXA 20 minutes before surgery followed by continuous TXA infusion at rate of 1 mg/kg/min till end of surgery.Group C did not receive prophylactic TXA, but both groups received a booster dose of 2 gm TXA if required.Patients were monitored for the frequency and severity of hypotension and dose of ephedrine used.Amount of bleeding since skin incision till 2-hours postpartum (PP), the frequency of patients had stopped PP bleeding till 2-hr PP and the total dose of oxytocin drugs and booster doses of TXA were recorded.Results: Hypotension was recorded in 53 patients (30.5%);only 12 patients had blood pressure <80 mmHg.The lowest blood pressure, frequency of hypotension, time of occurrence and duration of hypotension and the used dose of ephedrine showed non-significant difference between both studied groups.The amount of perioperative bleeding was significantly lower in TXA group compared to control group.Twenty parturient had continued PP bleeding for more than 2 hours PP with significantly (p=0.038)lower frequency of bleeders in TXA group.All women had continued bleeding received booster doses of TXA with a significantly higher dose in control group compared to TXA group.Conclusion: Preoperative administration of TXA significantly reduced perioperative bleeding with significant reduction of consumption of TXA booster doses and utrotonics without affecting safety.Fluid coloading allowed reduction of the frequency and extent of hypotension concomitant with spinal anesthesia.
Implementing Alternative Communication using a Limited Number of Simple Sign Language Gestures

Field: Computer Science (Physical Sciences)

The article discusses one of the approaches to the implementation of alternative communication using non-verbal communication means. It is proposed to use human finger configurations as input controls. A model of a human hand is proposed for the implementation of the dactyl alphabet of sign language for the deaf. The possibilities of existing hand tracking devices have been investigated. An application has been developed to identify a set of finger configurations that are reliably recognized by front stereo cameras. A limited number of simple sign language gestures are defined that are convenient to show and easy to remember for people. A software module for text entry messages with a limited number of simple finger configurations has been developed. The main advantage of this approach is its ease of use and accessibility for people with temporary communication disabilities. Further research is focused on the use of dynamic gestures as controls.
FORMULATION AND EVALUATION OF OLANZAPINE FAST DISINTEGRATING TABLETS USING COPROCESSED SUPERDISINTEGRANTS

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Fast disintegrating tablets (FDT) have emerged as an alternative to oral conventional dosage forms to target populations like pediatric, geriatric, bedridden patients. The concept of coprocessing has been developed to obtain excipients with superior properties. The aim of this study was to prepare co-processed superdisintegrants using crospovidone, sodium starch glycolate, croscarmellose sodium, and use them in the formulation of FDT of Olanzapine. Tablets were prepared by direct compression and evaluated for wetting time, water absorption ratio and in vitro drug release. FTIR study indicated that there was no interaction between the drug and prepared coprocessed superdisintegrants. The dissolution studies showed that the use of coprocessed superdisintegrants resulted in rapid release of drug from the tablets. It can be concluded that coprocessed superdisintegrants can be successfully used in the formulation of fast disintegrating tablets.
Scandium doped Ge2Sb2Te5 for high-speed and low-power-consumption phase change memory

Field: Materials Science (Physical Sciences)

To bridge the gap of access time between memories and storage systems, the concept of storage class memory has been put forward based on emerging nonvolatile memory technologies. For all the nonvolatile memory candidates, the unpleasant tradeoff between operation speed and retention seems to be inevitable. To promote both the write speed and the retention of phase change memory (PCM), Sc doped Ge2Sb2Te5 (SGST) has been proposed as the storage medium. Octahedral Sc-Te motifs, acting as crystallization precursors to shorten the nucleation incubation period, are the possible reason for the high write speed of 6 ns in PCM cells, five-times faster than that of Ge2Sb2Te5 (GST) cells. Meanwhile, an enhanced 10-year data retention of 119 °C has been achieved. Benefiting from both the increased crystalline resistance and the inhibited formation of the hexagonal phase, the SGST cell has a 77% reduction in power consumption compared to the GST cell. Adhesion of the SGST/SiO2 interface has been strengthened, attributed to the reduced stress by forming smaller grains during crystallization, guaranteeing the reliability of the device. These improvements have made the SGST material a promising candidate for PCM application.
CIA2 Coordinately Up-Regulates Protein Import and Synthesis in Leaf Chloroplasts

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Plastid biogenesis and maintenance depend on the coordinated assembly of proteins imported from the cytosol with proteins translated within plastids. Chloroplasts in leaf cells have a greater need for protein import and protein synthesis than plastids in other organs due to the large amount of proteins required for photosynthesis. We previously reported that the Arabidopsis (Arabidopsis thaliana) transcription factor CIA2 specifically up-regulates leaf expression of genes encoding protein translocons Toc33 and Toc75, which are essential for protein import into chloroplasts. Protein import efficiency was therefore reduced in cia2 mutant chloroplasts. To further understand the function of CIA2, gene expression profiles of the wild type and a cia2 mutant were compared by microarray analysis. Interestingly, in addition to genes encoding protein translocon components, other genes down-regulated in cia2 almost exclusively encode chloroplast ribosomal proteins. Isolated cia2 mutant chloroplasts showed reduced translation efficiency and steady-state accumulation of plastid-encoded proteins. When CIA2 was ectopically expressed in roots, expression of both the protein translocon and ribosomal protein genes increased. Further analyses in vivo revealed that CIA2 up-regulated these genes by binding directly to their promoter regions. We propose that CIA2 is an important factor responsible for fulfilling the higher protein demands of leaf chloroplasts by coordinately increasing both protein import and protein translation efficiencies.
Feasibility, Quality and Assessment of Interlingual Live Subtitling

Field: Arts and Humanities (Social Sciences)

Intralingual respeaking has been widely practiced since 2001 (Romero-Fresco, 2011), however, interlingual respeaking (from one language into another) is yet to take off. As a hybrid form of subtitling and interpreting, interlingual respeaking calls upon skills used in both professions. To transform this mode of audiovisual translation (AVT) within Media Accessibility (MA), a programme must be created to train future interlingual live subtitlers (ILSers). This paper presents the results of the first ever study on interlingual live subtitling (ILS), in which 10 participants interlingually respoke three short videos using a language combination of English and Spanish. The main areas of research in this project are feasibility, quality and training. Before expanding training in this area, ILS must be deemed feasible and an effective method of assessment must be in place to determine its quality. The average accuracy rate of the study is 97.17%, with the highest accuracy rate reaching the 98% threshold with 98.33%. The initial results point to ILS as feasible providing a training programme is put in place to build upon existing task-specific skills and develop new ones to ensure interlingual live subtitles of good quality are produced.
Inhibition of Prostate Cancer Metastasis in Vivo: A Comparison of 1,25-

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The steroid hormone 1,25-dihydroxyvitamin D [1,25(OH)2D, also known as calcitriol] is known to inhibit the proliferation and to promote the differentiation of human prostate cancer cells. Additionally, we showed that 1,25(OH)2D markedly inhibits the invasiveness of human prostate cancer cells in vitro (G. G. Schwartz et al., Cancer Epidemiol. Biomark. Prev., 6: 727–732, 1997). These properties support the use of 1,25(OH)2D as differentiation therapy in prostate cancer. However, the use of 1,25(OH)2D in vivo is limited by the risk of hypercalcemia. We therefore compared the effects of 1,25(OH)2D and of EB1089, an analogue of 1,25(OH)2D with reduced calcemic effects, in an in vivo model of androgen-insensitive metastatic prostate cancer, the rat Dunning MAT LyLu prostate cancer model. Tumor growth and metastasis were studied using Copenhagen rats given s.c. injections of MAT LyLu cells. Fifty male rats were divided into five groups of 10 rats each. Four experimental groups received i.p. injections of low and high doses of 1,25(OH)2D and EB1089 (0.5 and 1.0 mg/kg, low and high, respectively). A control group received injections of vehicle only. Tumor volumes were measured three times per week. Rats were weighed weekly. The number of metastases to the lungs and the extent of hypercalcemia were evaluated. Compared with controls, tumor volumes were significantly smaller in all experimental groups. Similarly, the number of lung metastases (number of foci/lung) was reduced markedly by both 1,25(OH)2D and EB1089. Control rats developed 22.7 (6 1.98 SE) tumor foci per lung. Rats treated with 1,25(OH)2D and with EB1089 (1.0 mg/kg) developed 10.4 (6 2.81) and 7.70 (6 1.29) tumor foci, respectively (P &lt; 0.001 and P &lt; 0.0001, respectively; drug versus control). Compared with controls (10.79 6 0.1 mg/dl), serum calcium levels were significantly elevated in both
AMBULATORY BLOOD PRESSURE MONITORING: THE NEED OF 7-DAY RECORD.

Field: Medicine (Health Sciences)

The need for systematic around-the-clock self-measurements of blood pressure (BP) and heart rate (HR), or preferably for automatic monitoring as the need arises and can be met by inexpensive tools, is illustrated in two case reports. Miniaturized unobtrusive, as yet unavailable instrumentation for the automatic measurement of BP and HR should be a high priority for both government and industry. Automatic ambulatorily functioning monitors already represent great progress, enabling us to introduce the concept of eventually continuous or, as yet, intermittent home ABPM. On BP and HR records, gliding spectra aligned with global spectra visualize the changing dynamics involved in health and disease, and can be part of an eventually automated system of therapy adjusted to the ever-present variability of BP. In the interim, with tools already available, chronomics on self- or automatic measurements can be considered, with analyses provided by the Halberg Chronobiology Center, as an alternative to "flying blind", as an editor put it. Chronomics assessing variability has to be considered.
Decreased CSF hypocretin-1 (orexin-A) after acute haemorrhagic brain injury

Field: Neuroscience (Life Sciences)

The novel hypothalamic neuropeptides orexins, or hypocretins, have gained much attention as potent modulators of various different physiological functions.1 Deficient orexin neurotransmission may be responsible for excessive somnolence, as shown in several conditions related to secondary narcolepsy, through direct or indirect damage to the posterior hypothalamus and its connections.2 We have studied for the first time the longitudinal changes of hypocretin-1 concentrations in cerebrospinal fluid (CSF) in patients with acute haemorrhagic brain injury.

Nine patients from a previously reported cohort3 and 21 controls (seven women and five men, median age 38 years, range 17 to 70) with other neurological disease were enrolled in the study (table 1). The patient group included five subjects with intracerebral haemorrhage and five with subarachnoid haemorrhage (table 1). All patients had extraventricular drains inserted within a median of two days of disease onset (range 2 to 36) as a treatment procedure because of increasing signs of hydrocephalus. Morning CSF samples were collected twice: first between day 1 and day 2 after catheter insertion, and second between day 4 and day 10. Patients were assessed using the Glasgow coma scale (GCS) at …
Antiepileptics for seizure prophylaxis after traumatic brain injury

Field: Medicine (Health Sciences)

We read with great interest the recent review by Torbic et al.[1][1] on antiepileptic drugs (AEDs) for seizure prophylaxis after traumatic brain injury (TBI). The majority of the article focused on the published literature evaluating various AEDs for the prevention of early posttraumatic seizure (
Mitochondrial Ubiquitin Ligase MITOL Ubiquitinates Mutant SOD1 and Attenuates Mutant SOD1-induced Reactive Oxygen Species Generation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

We have previously identified a novel mitochondrial ubiquitin ligase, MITOL, which is localized in the mitochondrial outer membrane and is involved in the control of mitochondrial dynamics. In this study, we examined whether MITOL eliminates misfolded proteins localized to mitochondria. Mutant superoxide dismutase1 (mSOD1), one of misfolded proteins, has been shown to localize in mitochondria and induce mitochondrial dysfunction, possibly involving in the onset and progression of amyotrophic lateral sclerosis. We found that in the mitochondria, MITOL interacted with and ubiquitinated mSOD1 but not wild-type SOD1. In vitro ubiquitination assay revealed that MITOL directly ubiquitinates mSOD1. Cycloheximide-chase assay in the Neuro2a cells indicated that MITOL overexpression promoted mSOD1 degradation and suppressed both the mitochondrial accumulation of mSOD1 and mSOD1-induced reactive oxygen species (ROS) generation. Conversely, the overexpression of MITOL CS mutant and MITOL knockdown by specific siRNAs resulted in increased accumulation of mSOD1 in mitochondria, which enhanced mSOD1-induced ROS generation and cell death. Thus, our findings indicate that MITOL plays a protective role against mitochondrial dysfunction caused by the mitochondrial accumulation of mSOD1 via the ubiquitin–proteasome pathway.
Therapeutic Colorectal Cancer Vaccines: Emerging Modalities and Translational Opportunities

Field: Medicine (Health Sciences)

Therapeutic vaccines offer a targeted approach to enhancing anti-tumor immunity with minimal systemic toxicity. Despite advancements in surgery, chemotherapy, radiation, and immunotherapy, colorectal cancer (CRC) remains a major clinical challenge, particularly due to the limited efficacy of immune checkpoint inhibitors outside the MSI-H subgroup. In this comprehensive review summarizes the emerging vaccine modalities for CRC, including peptide, nucleic acid, cell-based, vector-driven, and nanotechnology platforms. We discuss the barriers posed by tumor immune evasion and heterogeneity, and highlight innovative strategies designed to improve vaccine efficacy. Finally, we explore recent clinical developments and translational opportunities that position therapeutic vaccines as a promising component of future CRC immunotherapy.
Human Protection across Regions: Learning from Norm Promotion and Capacity Building in Southeast Asia and Africa

Field: Social Sciences (Social Sciences)

This article introduces the special issue on ‘Human Protection across Regions: Learning from Norm Promotion and Capacity Building in Southeast Asia and Africa’. It identifies the aims and objectives of the Southeast Asia-Africa dialogue from which the contributions in this special issue emerged and briefly explains the background of the contributors. It then proceeds to lay out the structure and major arguments of each contribution in the context of norm promotion and capacity building in the two regions.
A Comparative Analysis of Politeness Strategies in the Animated Cartoon Angelo Rules and Its Dubbed Arabic Version

Field: Arts and Humanities (Social Sciences)

The aim of this paper is to compare the politeness strategies in the English version of the animated cartoon Angelo Rules with those in the dubbed Arabic version, focusing on whether the different cultures have an effect on the politeness strategies used. The data for the analysis came from four episodes in English and four episodes in Arabic that were identical to the English episodes, and the analysis was based on Brown and Levinson’s framework. The study examined the use of positive politeness, negative politeness and bald on-record strategies by the characters. The findings revealed the existence of positive politeness, negative politeness and bald on-record strategies, which were found in nearly all the English and Arabic episodes analysed. Positive politeness (in particular, exaggerating interest and including both the speaker and hearer in the activity) and bald on-record strategies were the most commonly used in the selected data. Furthermore, no significant difference in politeness strategies used was found between the four English episodes and the same episodes dubbed into Arabic.
Optimization of diacylglycerol production from lipase-catalyzed glycerolysis of rice bran oil by response surface methodology

Field: Chemical Engineering (Physical Sciences)

Response surface methodology(RSM) was applied to optimize the diacylglycerol(DAG) production from Novozym 435-catalyzed glycerolysis of rice bran oil in t-Butanol system.Based on single-factor analysis,5-level-4-factor central composite rotatable design(CCRD) was employed to evaluate and optimize the effect of DAG synthesis parameters,such as reaction temperature,time,enzyme amount(mass ratio of lipase to rice bran oil),and substrate mass ratio(rice bran oil:glycerol).The results indicated that substrate mass ratio was the most important variable.Considering the economical efficiency as well as optimization,the optimum DAG synthesis conditions with the yield of 53.08% were as follows:reaction temperature 60℃,time 10.5h,enzyme amount 10.66%,substrate mass ratio 16.