jimnoneill/paper-to-field-training huggingface dataset:
Çok amaçlı açık arttırmalar içi çözüm yaklaşımları.

Field: Decision Sciences (Social Sciences)

There is a growing interest in electronic auctions in the literature. Many researchers work on the single attribute version of the problem. Multi-attribute version of the problem is more realistic. However, this brings a substantial difficulty in solving the problem. In order to overcome the computational difficulties, we develop an Evolutionary Algorithm (EA) for the case of multi-attribute multi-item reverse auctions. We generate the whole Pareto front using the EA. We also develop heuristic procedures to find several good initial solutions and insert those in the initial population of the EA. We test the EA on a number of randomly generated problems and compare the results with the true Pareto optimal front obtained by solving a series of integer programs. We also develop an exact interactive approach that provides aid both to the buyer and the sellers for a multi-attribute single item multi round reverse auction. The buyer decides on the provisional winner at each round. Then the approach provides support in terms of all attributes to each seller to be competitive in the next round of the auction.
Similarities of stress granules and cytosolic prions

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Eukaryotic cells contain several organelles that lack a delimiting membrane. These membrane-less organelles take over important functions within the cell and influence biological reactions by condensing nucleic acids and proteins into dense droplets. Upon environmental stress, one kind of membrane-less organelle, termed stress granules, assembles to sequester non-essential mRNA transcripts while translation is stalled. Together with RNA-binding proteins, mRNA transcripts form a network by multiple weak interactions within stress granules. Many RNA-binding proteins thereby facilitate the assembly of stress granules by their low-complexity or prion-like domains, which were identified based on their structural similarities with yeast prion domains. Several RNA-binding proteins that are part of stress granules were found aggregated in degenerative disorders. Therefore, stress granules have been proposed to contribute to the disease process by acting as nucleation sites for protein aggregates, which might evolve into pathological protein inclusions over time. In this study, we compared similarities and differences between stress granules and cytosolic prion aggregates. Specifically, we tested the hypothesis if recruitment of a protein with a prion-like domain to stress granules induces its conversion into a protein aggregate with self-perpetuating properties. To this end, we made use of the yeast prion domain NM of Sup35, expressed in mammalian cells, that can form cytosolic prions upon exposure to recombinant NM fibrils. Here we show that the interactome of NM prions significantly overlaps with that of stress granules. The presence of neither soluble nor aggregated NM altered the dynamics of stress granules, but stress granule disassembly was slightly impaired. Importantly, prolonged presence of stress granules did not induce NM aggregation, but rather led to cell death. Interestingly, chemicals that induce stress granules drastically increased NM aggregate formation upon concomitant induction with recombinant NM fibrils. However, stress granules per se were not required for the increased induction rate, as concomitant exposure to drugs or siRNA that interfere with stress granule formation did not lower the NM aggregate induction rates. We propose a model where stress that triggers a stress granule response results in a cellular environment that allows more effective protein aggregate induction by exogenous seeds. One possible explanation for this is that the cellular quality control mechanism is overloaded under stress and thus cannot combat the additional aggregate induction by an exogenous seed. Therefore, the role of stress granules in the pathogenesis of neurodegenerative disorders might be different than so far anticipated. Still, triggers that cause stress granule formation enhance protein aggregation in the presence of exogenous seeds, thereby likely contributing to disease progression.
The Role of Multiple Dimensions of Organized Activity Participation, Impulsivity, and Parental Monitoring on Externalizing Behavior among Low-Income, Urban Adolescents.

Field: Psychology (Social Sciences)

Because the majority of teenage deaths are not due to illness, but instead attributed to risk behaviors, it is pertinent to determine under what circumstances adolescents are likely to injure themselves or others. One well-studied protective factor of adolescent externalizing behaviors is participation in organized activities. Unfortunately, the majority of research involving adolescents’ engagement in organized activities examines single dimensions of participation (intensity, duration, and breadth) at a time, within samples of middle-class, Caucasian youth. Few studies have examined how multiple dimensions of participation in organized activities, including how uninterrupted engagement in organized activities from school year to summer months, simultaneously protects against engagement in substance use and externalizing behavior for low-income, ethnically diverse adolescents.\nThis study utilizes self-report from a sample of 278 ethnic-minority adolescents and parents across late adolescence (m=16.88, sd=.44). The overall goals of this project are 1) to examine how different patterns of participation in organized activities uniquely and simultaneously predict substance use and externalizing behaviors, above and beyond impacts of impulsivity and parental monitoring, and 2) to test the measurement and structural invariance of these relations between a low-risk and high-risk subsample of youth who engage in externalizing behaviors. Results indicate few individual impacts of organized activity participation, with the exception of breadth of participation among a low-risk subsample. Additionally, parental monitoring and impulsivity remained significant predictors of externalizing and substance use\nbehaviors only within the high-risk subsample, while in the low-risk subsample only impulsivity remained a significant predictor. The findings of this study contribute to the knowledge\nregarding when and under what circumstances adolescents engage in risk behaviors, as well as what factors are important to prevent them from occurring.
D-BLAST with group zero-forcing detection: Diversity and multiplexing tradeoff analysis

Field: Computer Science (Physical Sciences)

Recently, a new efficient detection method referred to as group zero-forcing (GZF) was proposed to achieve low complexity and high diversity for MIMO systems. In this paper, a diversity and multiplexing tradeoff (DMT) analysis is given for diagonal-BLAST (D-BLAST) MIMO with GZF detection over Rayleigh fading channels. It is shown that the DMT of such group detection is d(r) = (N - 1)(M - r(M+1)/2) + for r ≥ 2/M+1 and d(r) = (MN - M + 1) - rN(M+1)/2 for 0 ≤ r <; 2/M+1 for MIMO with M transmit antennas and TV receive antennas, where d denotes the diversity gain and r is the multiplexing gain.
Recovering Nussbaum's Aristotelian roots

Field: Arts and Humanities (Social Sciences)

Purpose The paper aims to examine the relationship between creating capabilities and political liberalism. It argues that the reality of climate change calls for the capabilities approach to be more rooted in a relational anthropology which the Aristotelian ethical tradition is more akin to. Design/methodology/approach It discusses how traces of this ethical tradition can be found in Nussbaum's capabilities approach itself: affiliation as an architectonic capability leads to the common good being the end of political action, and practical reason as an architectonic capability leads to reasoning being structured by concerns for the common good. Findings The paper suggests some practical implications of an Aristotelian version of the capabilities approach. Originality/value The paper seeks to build an account of social justice based on the capabilities approach with Aristotelian roots.
Blood-Based Multi-Cancer Early Detection Tests (MCEDs) as a Potential Approach to Address Current Gaps in Cancer Screening

Field: Medicine (Health Sciences)

Screening and early detection is one of the most effective approaches to reduce the population-level impact of cancer. Novel approaches to screening such as multi-cancer early detection tests (MCEDs) may further reduce cancer incidence and mortality. Many MCEDs detect fragments of circulating DNA containing mutations that originated from tumour cells, thereby informing both the presence of cancer and the cell-type of origin. In this review, we examine the current evidence of MCEDs as a potential tool to improve population-based cancer outcomes. We review the role of MCEDs to address low participation rates, disparities among underserved populations, changing epidemiology of common cancers, and the absence of screening tests for many cancer types. MCEDs have the potential to increase participation in cancer screening programs, as they may be less invasive than other procedures, and can screen for multiple cancer types in one appointment. Additionally, due to the lack of specialized collection equipment needed for these tests, underscreened populations and targeted populations could gain greater access to screening. Finally, because MCEDs can detect cancer types without screening tests that are moderately common and increasing in western populations, efficacious tests for these sites could alleviate the cancer burden and improve patient outcomes. While these tests offer great promise, considerable limitations and evidence gaps must be addressed. Notable limitations include scenarios where early detection does not improve survival outcomes, the costs and impact on health care resources for false positives, and false reassurance with subsequent lack of adherence to existing screening protocols.
Assessing Needs of Families with Handicapped Infants

Field: Health Professions (Health Sciences)

A 35-item parent survey was developed to assess the functional needs of parents with young handicapped children. A rationale for scale development and content is presented. Data from 34 two-parent families with handicapped infants suggest that the instrument is a useful source of intervention goals. Several items emerged as high priority needs for mothers and fathers. Addition of an open-ended response format provided a considerable amount of useful information. A readministration of the measure 6 months later with a subset of 20 families yielded high correlations. Implications of these findings for clinicians working with families of young handicapped children are discussed.
Novel Natural Agents from Lamiaceae Family: An Evaluation on Toxicity and Enzyme Inhibitory Potential Linked to Diabetes Mellitus

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Medicinal plants are rich sources for drug discovery. Occurrence of Diabetes mellitus is increasing because of changes in human lifestyle. So, design or discovery of new and more effective and safer drugs is needed. At the present study, the enzyme inhibitory effects of methanol extracts of selected Lamiaceae species (Salvia syriaca L., Teucrium polium L., Phlomis olivieri Benth., Nepeta ispahanica Boiss., Scutellaria tomentosa Benth., Salvia limbata C.A. Mey., Teucrium orientale L., Salvia atropatana Bunge., Salvia nemorosa, Salvia multicaulis Vahl., Ajuga chamaecistus Ging. ex Benth., Mentha longifolia L. and Satureja khuzestanica) were evaluated. The enzyme inhibitory activities were tested against -amylase and -glucosidase, which are linked to diabetes. Also, brine shrimp lethality assay was used to determine the cytotoxicity of the extracts. All methanol extracts showed moderate to high inhibitory effects on the tested enzymes. Scutellaria tomentosa and Mentha longifolia exhibited the strongest -amylase and -glucosidase inhibitory effects, respectively. These activities were ranged from 0.135 to 0.291 mmol in α-amylase assay and 1.256 to 6.640 mmol acarbose equivalents/g extract in -glucosidase assay. The highest cytotoxic effect was observed for the extract of S. syriaca roots (LC50 = 12.3 µg/ml). The results suggest that these Lamiaceae species could be considered as a source of natural agents for the preparing of new pharmaceuticals and functional foods especially for the management of Diabetes mellitus. Keywords: Lamiaceae, diabetes mellitus, Salvia, Mentha, drug discovery.
Higher education during the pandemic. An overview of the higher education system in Uzbekistan

Field: Social Sciences (Social Sciences)

The article focuses on the development of the education system in Uzbekistan after the country gained independence. It highlights the obstacles to the development of the education system and changes during the pandemic, particularly in the sphere of higher education. The purpose of this research is to provide an overview of the steps in the development of education within the state. It will also evaluate the present condition of higher education during the pandemic. The conclusion states the findings and recommendations for further development.
A study of online trading system in India

Field: Economics, Econometrics and Finance (Social Sciences)

This research is related to examines the new wave of online trading with respect to industries, brokerages. Stock market is one of the important elements of the Indian economy which determines the economic growth of India and financial state of the country. In today’s world there are millions of people are connected to the internet and many of them are from rural background. Last 30 years since 1991, GPL (Globalization, Privatization, Liberalization) the internet has impacted much on people perception. The customer satisfaction is only thing that make a business successful. The present study to find out the customer awareness towards online trading. The main objective of the study is to understand the how the online trades take place. The major reason for investing in the share market is convincing and easy to handle.
Analysis of the 70-gene breast cancer prognosis signature in a general hospital population.

Field: Medicine (Health Sciences)

B174 CONFIDENTIAL  Introduction:  A 70-gene microarray gene expression signature was previously discovered at the Netherlands Cancer Institute (NKI) to identify younger breast cancer patients (age Methods:  We determined the negative and positive predictive value of the 70-gene signature in unselected breast cancer patients who were consecutively diagnosed and treated at the Massachusetts General Hospital (MGH) between 1985 and 1997. Primary tumors from 101 patients with node negative, invasive breast cancer (median age 62 years) were subjected to microarray expression analysis using the 70-gene MammaPrint assay and were classified as being at either low or high risk for distant metastasis.  Results:  MGH node-negative patients differed significantly from previously studied, node-negative NKI patients with respect to age, tumor size, histologic grade, and adjuvant hormonal and / or chemotherapy (p Conclusion:  The 70-gene signature was originally designed to identify younger breast cancer patients at low risk for distant metastasis, who might consequently be spared systemic treatment. We show here that the same signature can also identify older breast cancer patients at low risk for metastatic disease. That fewer of the older age high risk patients developed metastatic disease compared to previously reported studies in younger patients may have two causes. First, these results might reflect host differences in younger versus older breast cancer patients that are associated with propensity to metastasize ( i.e . the same seed may have different metastatic behavior in a different (post menopausal) soil). Second, the patients in the MGH cohort received considerably more adjuvant therapy than the patients from the NKI study (mostly untreated patients), which is likely to have reduced recurrence rates in the MGH patients.  #
Impact of nitrogen and potassium management on growth, nutrient uptake and nutrient use efficiency of rice under semi dry condition

Field: Agricultural and Biological Sciences (Life Sciences)

The current study was aimed to search effect of nitrogen doses and time of application on performance of semi dry rice. The field experiment was conducted at College of Agriculture,(V. C. Farm), Mandya, University of Agricultural Sciences, Bengaluru during kharif 2019 and 2020, which comes under Southern Dry Zone of Karnataka (Zone-VI) to study the response of semi dry rice on growth and nutrient use efficiency under two doses of nitrogen and potassium doses (100% RDNK, 125%RDNK) as main treatments and seven time of application as sub treatments.The result revealed that higher SPAD meter reading (37.77) and nutrient uptake (77.90, 27.98 and 24.14 kg ha-1)was seen in 125% RDNK and higher nitrogen and potassium use efficiency was observed in 100%RDNK (49.30, and 98.59 kg kg-1 nutrient applied respectively). Where as in split application, higher SPAD meter reading (38.90), nutrient uptake (81.82, 29.57 and 25.35kg ha-1)and nutrient use efficiency (49.86, 11.33 and 99.73 kg kg-1 nutrient applied respectively) was recorded in N at 4 splits as, 25% each at sowing, early tillering, tillering and panicle initiation, K at 2 splits (50% at basal and 50% at panicle initiation) compared to rest of the application. Hence application of application of 125% RDNK, N at 4 splits as, 25% each at sowing, early tillering, tillering and panicle initiation, K at 2 splits (50% at basal and 50% at panicle initiation) is the appropriate time for rice production Southern Dry Zone of Karnataka.
Retrospective-cost-based model refinement for system emulation and subsystem identification

Field: Computer Science (Physical Sciences)

We consider the problem of data-based model refinement, where we assume the availability of an initial model, which may incorporate both physical laws and empirical observations. With this initial model as a starting point, our goal is to use additional measurements to refine the model. In particular, components of the model that are poorly modeled can be updated, thereby resulting in a higher fidelity model. We consider two special cases, namely, system emulation and subsystem identification. In the former case, the main system is assumed to be uncertain and we seek an estimate of the unknown subsystem that allows the overall model to approximate the true system. In this case, there is no expectation that the constructed subsystem model approximates the unknown subsystem. In the latter case, we assume that the main system is accurately modeled and we seek an estimate of the unknown subsystem that approximates the unknown subsystem.
2. Retrospect of Criminal Anthropology.

Field: Social Sciences (Social Sciences)

The “Year Book” of the Elmira Reformatory for 1892 is an admirably produced volume; it contains, also, a very large number of process illustrations from photographs, as well as 100 woodcut portraits of inmates with accompanying histories. Like last year's “Year Book,” it is the product of the intelligence, skill, and industry of inmates engaged on the institutional journal, “The Summary.”
Results of a Phase 2 Clinical Trial Testing the Efficacy of Plerixafor in Combination with Chemotherapy in the Mobilization of Autologous Blood Hematopoietic Progenitor Cells

Field: Medicine (Health Sciences)

The use of plerixafor for mobilization following chemotherapy has not been extensively studied. We tested the hypothesis that adding plerixafor to G-CSF after chemotherapy would increase the proportion of patients mobilizing the target number of hematopoietic progenitor cells in one day to 75% from a historical value of 50%. Multiple myeloma (MM) or lymphoma patients for whom autologous stem cell transplantation was intended were eligible. Patients were mobilized with chemotherapy consisting of either cyclophosphamide (N=16), DCEP (N=1), R-ICE (N=10), CHOP (N=2) or R-HyperCVAD (N=5) with daily administration of G-CSF at a dose of 10 mcg/kg/day starting one day after the completion of chemotherapy. The per-protocol plan was subcutaneous injection of 240 mcg/kg plerixafor on the first day on which the neutrophil count was > 1500 cells/uL followed by apheresis the next day. G-CSF, plerixafor and apheresis were repeated daily until 5 (lymphoma) or 10 x 10E6 CD34+ cells/kg (myeloma) were collected. 17 MM and 28 lymphoma patients with a median age of 57 (range 33-73) were enrolled. 33/45 subjects (76%) collected the target number of CD34+ cells in one day. 12 subjects (7 MM and 5 lymphoma) with a median CD34+ count of 201 cells/uL began apheresis without plerixafor on the first day of monitoring and collected a median of 19 x 10E6 CD34+ cells/kg in one day. The remaining 33 patients (10 MM and 23 lymphoma) received plerixafor with median numbers of 30 CD34+ cells/uL, and 4100 neutrophils/uL that increased to 95 CD34+ cells/uL and 24,799 neutrophils/uL the next day. Plerixafor-treated subjects collected a median of 7.8 x 10E6 CD34+ cells/kg; 22 (66%) collected the target number in one day, while 6 (18%), 3 (9%), and 2 (6%) of the plerixafor-treated subjects required 2, 3, or 4 days of apheresis, respectively. Plerixafor was well tolerated, with 29 total AE, and no SAE recorded during mobilization and/or apheresis. Seven grade 3/4 AE were seen, including thrombocytopenia (4), fatigue (1), anemia (1) and hypokalemia (1). 44/45 enrolled subjects underwent high-dose chemotherapy and re-infusion of CD34+ cells. Plerixafor-treated and non-plerixafor treated transplant recipients promptly engrafted with neutrophil and platelets at median of 12 and 16 days, respectively, with stable hematopoiesis noted at 12 months. Plerixafor administration after chemotherapy for ASC mobilization is feasible and well tolerated. A greater percentage (76%) of enrolled subjects collected more than the target number of cells in one day of apheresis compared with a historical cohort of patients mobilized with G-CSF after chemotherapy (54%; P < 0.03). Daily monitoring of blood counts after chemotherapy is needed to appropriately schedule plerixafor administration. One-fourth of chemotherapy-treated patients mobilized an adequate number of CD34+ in one day without plerixafor.
Pervasive Sensing for Real-Time Rainfall Quantification

Field: Earth and Planetary Sciences (Physical Sciences)

The proliferation of wireless sensors in everyday consumer products presents new opportunities to monitor the environment at unprecedented space and time scales. This study explores the utility of pervasive sensors for improving the resolution of areal precipitation estimates through fusion with weather radar observations. While these sensors are not specifically designed to measure rainfall intensities, the data they collect can be repurposed to provide quantitative measurements of environmental variables at the location of the sensor. Due to different measurement accuracies (which may be time dependent), types of spatial and/or temporal measurement support, and measurement frequencies of the component sensors, it is unclear how best to combine measurements from pervasive sensors with those from traditional sensors. The method developed in this study employs Markov random field models to compute the likelihood of rainfall at sub-grid pixels. These likelihoods are used to "unmix" the block-averaged rainfall rate measured by the radar. The statistical nature of the model permits the data evidence to drive the fusion of the sensors' measurements. The performance of these methods will be illustrated using case studies exploring synthetic and real-world data.