jimnoneill/paper-to-field-training huggingface dataset:
PUS7‐dependent pseudouridylation of ALKBH3 mRNA inhibits gastric cancer progression

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Background RNA pseudouridylation is a critical post‐transcriptional modification that influences gene expression and impacts various biological functions. Despite its significance, the role of mRNA pseudouridylation in cancer remains poorly understood. This study investigates the impact of pseudouridine synthase 7 (PUS7)‐mediated pseudouridylation of Alpha‐ketoglutarate‐dependent Dioxygenase alkB Homolog 3 ( ALKBH3 ) mRNA in gastric cancer. Methods Immunohistochemistry and Western blotting were used to assess PUS7 protein levels in human gastric cancer tissues. The relationship between PUS7 and gastric cancer progression was examined using 3D colony formation assays and subcutaneous xenograft models. Real‐time quantitative PCR (RT‐qPCR), Western blotting, and polysome profiling assays were conducted to investigate how PUS7 regulates ALKBH3. A locus‐specific pseudouridine (Ψ) detection assay was used to identify Ψ sites on ALKBH3 mRNA. Results Our findings indicate a significant reduction of PUS7 in gastric cancer tissues compared to adjacent non‐tumour tissues. Functional analyses reveal that PUS7 inhibits gastric cancer cell proliferation and tumour growth via its catalytic activity. Additionally, PUS7 enhances the translation efficiency of ALKBH3 mRNA by modifying the U696 site with pseudouridine, thereby attenuating tumour growth. Importantly, ALKBH3 functions as a tumour suppressor in gastric cancer, with its expression closely correlated with PUS7 levels in tumour tissues. Conclusions PUS7‐dependent pseudouridylation of ALKBH3 mRNA enhances its translation, thereby suppressing gastric cancer progression. These findings highlight the potential significance of mRNA pseudouridylation in cancer biology and suggest a therapeutic target for gastric cancer. Highlights PUS7 enhances the translation efficiency of ALKBH3 through its pseudouridylation activity on ALKBH3 mRNA, thereby inhibiting gastric tumourigenesis. The expression levels of PUS7 and ALKBH3 are significantly correlated in gastric tumours, which may be potential prognostic predictors and therapeutic targets for patients with gastric cancer.
UHMWPE with short‐chain branches synthesized by alkenyl substituted phenoxy–imine catalysts in ethylene polymerization

Field: Chemistry (Physical Sciences)

ABSTRACT The alkenyl substituted phenoxy–imine complexes [2‐C 3 H 5 ‐6‐(2, 3, 5, 6‐C 6 F 4 H‐NCH)C 6 H 3 O] 2 TiCl 2 (C 3 H 5 =CH 2  CHCH 2 or CHCHCH 3 ) are synthesized and characterized by 1 H NMR, 13 C NMR, and elemental analysis. When activated by MAO, they show high activity for the polymerization of ethylene to UHMWPE under different conditions (temperatures and polymerization time). Most of the resulting polymers have high molecular weights (>1.0 × 10 6 g·mol −1 ) and high melting points as well as crystallinity. To clarify the effect of the alkenyl group on the catalytic performance and the resultant polymer microstructure, the corresponding saturated complexes of type [2‐C 3 H 7 −6‐(2, 3, 5, 6‐C 6 F 4 H‐NCH)C 6 H 3 O] 2 TiCl 2 where C 3 H 7 = –CH 2 CH 2 CH 3 or CH(CH 3 ) 2 were synthesized and tested as catalysts in ethylene polymerization under the same reaction conditions. The microstructure and morphologies of these two species of PE samples were fully compared by the analysis of 13 C NMR, GPC, DSC, and SEM. As a result, the allyl substituted complex show the highest activity to prepare the highest molecular weight polyethylene of all the catalysts. An interesting feature of the UHMWPE produced by these four catalysts is that they contain only a few short‐chain branches (mainly methyl, isobutyl and 2‐methylhexyl branches) in a low amount (<2.7 branches/1000 C). © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54 , 3808–3818
Diagnosis and Management for Temporomandibular Disorders under Consideration of the Etiology

Field: Dentistry (Health Sciences)

睡眠時のパラファンクションである睡眠時ブラキシズムは顎機能障害（Temporomandibular Disorders; TMD）の原因因子として古くから注目され，両者の因果関係について数多くの研究成果が蓄積されてきた．また，覚醒時に行われる日中クレンチング（Daytime clenching）についてもTMDの原因因子として捉えられてきたが，近年，強力なクレンチングのみならず歯を合わせる程度の軽度な咬合接触を行う習癖（Tooth Contacting Habit; TCH）についても研究がすすみ，TMD患者の中に高頻度でTCHが認められることが明らかになってきた．また，TCHについては補綴歯科領域で対処を求められる咬合感覚異常との関連性が示唆されており，臨床的には検出できない咬合の不具合を訴える患者が高頻度で歯を合わせる習慣をもち，その結果としてTMD症状を呈するという臨床的な観察も報告されている．本総説では睡眠時ブラキシズムならびにTCHとTMDの関連についての最新の知見を紹介し，TMD患者のパラファンクションへの対応について解説する．
The Governance of human resources in the Vietnamese healthcare system: A critical analysis of maternity services

Field: Health Professions (Health Sciences)

This thesis utilised mixed-methods study design to understand the factors that influence the translation and implementation of central human resources in health policy at the district and commune health levels. It provided recommendations for changes to enhance governance approaches to human resources for health policy implementation at local and national levels. This thesis has also contributed to the evolution of the theory on health staff motivation and performance through the description and testing of a new model, using data from a survey on 262 health staff and 43 in-depth interviews conducted in two northern mountainous provinces of Vietnam.
Research for the relationship betwen P~(53) and apoptosis in pancreatic cancer

Field: Medicine (Health Sciences)

The expression of P~(53) protein and apoptosis index on paraffin-embedded sections from 150 cases of normal and abnormal pancreatic tissues,which 97 cases of pancreatic carcinoma,32 pancreatitis and 21 normal pancreatic tissues were detected by the SP immunohistochemistry and the TUNEL method.Resutls(1)The ratios of P~(53) expresion in three calsses tissues were 59.8%,3.1% and 0% respectively.The apoptosis mean indexes in three classes tissues were 13.15±8.3，14.21±9.0 and 11.67±7.9 respectively.(2)The expressions of P~(53) gene protein was related to the differentiated degree,transplant transfer of tumor cells and TNM stage of patients and was no relationship between age,sex,the location of tumor and size(P>0.05).The positive atio fo P~(53) was dramatically higher in the lower differentiated adenocarcinoma transfer and TNM stage III and IV tumor cells than that in higher differentiated adenocarcinoma,no transfer and TNM stage I and II tumor cells respectively(P<0.05).Meanwhile,the survivla time(18.7+-6.9mon) in post-opeatign carcinomas patients expressed of P~(53) protein was shorter than that in negative (39.5+-03.4mon).(3)There was an inverase correlation between P~(53) and apoptosis in pancreatic tumor.Apoptosis was related to expression of P~(53) protein in pancreatic cancer.The mechanism P~(53) inhabiting apoptosis in which P~(53) protein was overexpression took part in important role in the produce and develoment of pancreatic tumor,especially in the later stage,P~(53) could be taken as an important indicator in the prognosis of pancreatic cancer.
THE IMPORTANCE OF MODELING THE FORMATION AND EFFECTIVENESS OF INTERNAL CONTROL MECHANISM IN TRANSITION COUNTRIES SUCH AS THE REPUBLIC OF SERBIA

Field: Business, Management and Accounting (Social Sciences)

The authors of this paper have tried to use the importance of the use of internal control in business, especially since there are a number of public and other companies that operate without the existence of internal control mechanics. It is particularly important to establish in the public sector because the same business with taxpayers' money. Thus the modeling can be a useful tool to get to the assurances regarding the importance of establishing internal controls and internal control mechanisms in the ordinary course of business. In addition, the establishment of internal controls, improve the safety of operations, and to achieve this it is necessary to devise a means of whom will be enhanced reporting management. Surely reports to management are an essential prerequisite for making valid and timely decisions to increase business performance. The authors have provided a model imbued with meaning by which will be enhanced reporting management, the authors point out that there is no universal model, and this is just one possible approach to this problem.
Assessment the Contact Toxicity of Methyl Palmitate on the Carmine Spider Mite

Field: Agricultural and Biological Sciences (Life Sciences)

Our previous studies showed that methyl palmitate had the acaricidal activity to T. viennensis. However, the mechanism of action of methyl palmitate on T. viennensis is unknown. Here, the toxicosis symptoms of T. viennensis exposed to methyl palmitate were studied to preliminarily uncover the acaricidal mechanism of methyl palmitate. Methyl palmitate caused dose-dependent mortality of T. viennensis in our studies. A moderate dose of methyl palmitate (5 mg/mL) initially elicited excite, and early oviposit without spinning. After a few hours, limb twitching was observed, and this was followed by a stage of depressed activity in about 5 hours. Subsequently, the mites developed a condition, which had the outward appearance of exosmosis on the back of the mites during the 15 th -20 th hr, and reduced eggs production. The mites eventually died in a few hours. Some typical neurotoxin symptoms such as excitement and convulsions were observed on the mites exposed to methyl palmitate. Methyl palmitate might be a type of neurotoxin. Compared to other neurotoxic insecticide, poisoning with methyl palmitate is slow in mites. Furthermore, the effects caused at sub cellular level by methyl palmitate were evaluated by transmission electron microscopy. Serious damage in ultra structure was observed at a concentration of methyl palmitate (5 mg/mL). Autolysis of membranous structure was observed, especially in mitochondria, which may imply a novel action of methyl palmitate.
Creating and Strengthening Cybersecurity in the Republic of Moldova

Field: Computer Science (Physical Sciences)

Like most of the countries, Republic of Moldova faced the need of protecting its cyberspace against emerging cybersecurity threats. The lack of coordination between responsible institutions, established cybersecurity mechanisms, and well-trained specialists made private companies and public institutions an easy target for cyber attacks performed by malicious actors like hacktivist groups, terrorist organisations and state-sponsored companies. The consequences of such attacks damage reputation, business processes and affect the image of the country on the international scene. This article shares the experience of Moldova in the efforts of planning and building cybersecurity. It is written from the point of view of Moldova’s Cybersecurity Centre – CERT-GOV-MD, whose governmental status and active involvement in national cybersecurity development processes allow to provide a broad overview of different situations, in which Moldova and its state institutions found themselves, and the problems faced along the road to achieving the stated goal. In this regard, the article covers the period from the initiation of building cybersecurity until the most current results.
Women in Rural France: Mediators or Agents of Change? 1

Field: Social Sciences (Social Sciences)

This chapter argues that not only have women been part of the changes affecting French rural society, but they have contributed to the development of a culturally more urbanized and economically liberalized French society. It assesses the complex nature of their position in social, cultural and economic terms, and analyzes to what extent their contribution remains original and integral to the numerous changes affecting French rural society. The chapter provides the experiences of women in rural life. It shows that women are ready to play a major role, but they can only do so if they are given opportunities and conditions to generate projects and ideas. The uniqueness of women's position will be based not only on their role as mediators or agents of change, but also on the development and recognition of their own identity, specific competencies and qualities. Several explanations could be advanced to explain women's lack of visibility in the sphere of French agriculture.
Management of Class II furcation defects in dogs using combination of Propolis and Nanobone graft

Field: Veterinary (Health Sciences)

Background: Periodontal regeneration using complementary and alternative medicine has gained considerable attention recently. Propolis is a resinous hive product collected by honey bees from exudates and buds of plants and mixed with wax and bee enzymes.Objective: The aim of this study was to evaluate the effect of propolis as bone graft substitute in the management of experimental grade II furcation defects, and to compare its effect to nanobone and to Propolis/nanobone mixture. Material and Methods: Sixteen critical-sized furcation defects on the buccal surface of mandibular third and fourth premolars were surgically created in twelve dogs and divided into three groups. Group I; defects were filled with Propolis, Group II; defects were filled with nanohydroxyapatite graft and Group III; defects were filled with a combination of Propolis/ nanohydroxyapatite graft. Histologically and histomorphometric analysis of newly formed interradicular bone height and percentage were performed after one and three months. Results: After one month; the three experimental groups revealed the features of early periodontal tissues regeneration including cementum, newly formed bone with inserted newly formed PDL fibers. The propolis group showed the highest bone height and bone surface area. After three months; denser bone occupying larger surface area of the furcation defect were noted especially in the propolis group. Conclusion: The addition of nanobone to propolis showed better results than nano bone alone especially at early healing stage. However, it didn't show better results than the use of propolis alone.
Investigation of Radiated Emission Measurement Method above 1 GHz

Field: Engineering (Physical Sciences)

The limits and the measurement methods for the radiated emissions above 1 GHz have been published as CISPR22 Ed. 5 Amendment 1 and CISPR16-2-3 Ed. 1 Amendment 1, respectively, VCCI Technical Sub-committee has examined the measurement methods for the radiated emissions above 1 GHz. This paper describes the matter of the signal to noise ratio (S/N) for the radiated emission measurement system above 1 GHz, the setting for the video band width (VBW) of a spectrum analyzer and the influence that the rotational speed of a turntable and the sweep time of a spectrum analyzer exert on radiated emission measurement above 1 GHz, based on the measurement results.
STUDY ON SYNTHETIC PROMOTERS FOR RADIATION-INDUCIBLE GENE THERAPY

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Objective To synthesize promoters of radiation-mediated gene therapy and testify its radiation-inducible property. Methods The promoters for radiation-mediated gene therapy, containing six CArG elements, were synthesized with man-made complementary oligodenoxyrbi onucleotides. The enhancer regions of the CMV IE gene promoter in pCGFP were replaced by the synthetic promoters to construct the reporter plasmids pE-GFP. Green fluorescence protein (GFP) gene was used as reporter gene to analyse the radiation-inducible property. Results The GFP expression in Tca8113 cells, which were transfected with pE-GFP, was increased by induction of low lose γ-radiation. It was evident that the level of GFP expression observed was dependent on radiation dose, with maximal expression seen following 3Gy irradiation by 161% as compared with control group. Conclusion The synthetic promoters are responsive to low dose of ionizing radiation and the CArG elements can service as a molecular switch to enhance down-stream gene expression. The synthetic promoters are expected to make a valuable contribution to the development of future radiation-responsive vectors for gene therapy.
Graft Copolymerization of a Binary Mixture of Methyl-Acrylate and Acrylamide onto Polyamide Films by the Mutual Method

Field: Chemical Engineering (Physical Sciences)

Graft copolymerization onto polyamide-6,6 film has been studied by grafting a binary mixture of methyl acrylate and acrylamide using gamma rays from a 60 Co source as initiator by the mutual method in an aqueous medium. The effect of total dose, concentration of monomer, and amount of water on the percentage grafting (Pg) has been determined. The effect of alcohols of varying chain length on the Pg of the binary mixture has been studied. They all decreased it. However, the mixed solvent system (H 2 O + alcohol) at certain compositions was found to enhance it. A plausible mechanism for the graft copolymerization of the binary mixture (methyl acrylate + acrylamide) onto polyamide film by the mutual method has been proposed.
Robust Perception-Based Visual Simultaneous Localization and Tracking in Dynamic Environments

Field: Computer Science (Physical Sciences)

Visual Simultaneous Localization and Mapping (SLAM) in dynamic scenes is a prerequisite for robot-related applications. Most of the existing SLAM algorithms mainly focus on dynamic object rejection, which makes part of the valuable information lost and prone to failure in complex environments. This paper proposes a semantic visual SLAM system that incorporates rigid object tracking. A robust scene perception frame is designed, which gives autonomous robots the ability to perceive scenes similar to human cognition. Specifically, we propose a two-stage mask revision method to generate fine mask of the object. Based on the revised mask, we propose a semantic and geometric constraint (SAG) strategy, which provides a fast and robust way to perceive dynamic rigid objects. Then, the motion tracking of rigid objects is integrated into the SLAM pipeline, and a novel bundle adjustment is constructed to optimize camera localization and object' 6-DoF poses. Finally, the evaluation of the proposed algorithm is performed on publicly available KITTI dataset, Oxford Multimotion Dataset, and real-world scenarios. The proposed algorithm achieves the comprehensive performance of RPE t less than 0.07m per frame and RPE R about 0.03° per frame in the KITTI dataset. The experimental results reveal that the proposed algorithm enables accurate localization and robust tracking than state-of-the-art SLAM algorithms in challenging dynamic scenarios.
Management of tomato root-knot wilt complex caused by Meloidogyne incognita and Fusarium oxysporum f. sp. lycopersici through plant extracts

Field: Agricultural and Biological Sciences (Life Sciences)

Efficacy of different plant extracts were evaluated against root-knot wilt disease complex of tomato caused by Meloidogyne incognita and Fusarium oxysporum f. sp. lycopersici. Plant extracts were used both as seed treatment and seedling treatment with 2% concentration. Among tested plant extracts, NSKE was found most effective that reduces nematode population (No of Galls/ plant 20.68 & No of Egg masses/ plant 15.67) and wilt disease incidence 21.64 followed by garlic clove, it also significantly increase plant growth parameters (shoot length 53.07cm, root length 19.37cm, shoot weight 29.63g fresh & 7.30g dry and root weight 7.61g fresh & 2.25g dry).
Improving Theory and Research on Hazard Mitigation: Political Economy and Organizational Perspectives

Field: Social Sciences (Social Sciences)

This paper opens with a discussion of the progress that has been made to date in research and theory on mitigation. It goes on to suggest approaches that, by addressing neglected aspects of mitigation-related issues, may improve our understanding of the topic. Woven through the paper are calls for several shifts in emphasis with respect to studies on mitigation: (1) from a social system, consensus model to a conflict model on society and community; (2) from an event-based, discontinuous concept of disaster and mitigation to a view that stresses the continuity between ongoing social life and the disruption occasioned by natural and technological agents; (3) from the study of the social consequences of disasters to the study of aspects of the social order that increase risk and lead to disasters; and (4) from an individualistic, social psychological approach to mitigation to a perspective that takes into account macro-level social phenomena. Language: en
The first Betti numbers of certain locally trivial fibre spaces

Field: Mathematics (Physical Sciences)

It is well known that, for a compact, oriented, homogenous coset space G/H arising from a compact, semisimple Lie group G, one has b^G/H) ^ b^G) = 0.In this note, we announce the following generalization of that result : THEOREM 1.Let n:E -> Bbea locally trivial Riemannian fibre space, E and B compact, oriented Riemannian manifolds, with the fibres F -n~l(b) immersed in E as minimal submanifolds.Then b,{B) ^ b x {E)
Harnessing the Coil Electrospinning Method for Fabricating Superflexible and Multiscale-Patterned Fibrous Tubular Scaffolds with Topographical Features

Field: Materials Science (Physical Sciences)

The fibrous tubular scaffold (FTS) has potential as a vascular graft; however, its clinical application is hindered by insufficient mechanical properties. Inadequate mechanical properties of vascular grafts can lead to some serious side effects such as intimal hyperplasia, luminal expansion, and blood thrombogenicity. In this study, we developed a novel fibrous tubular scaffold comprising multiscale fibers to ensure superior mechanical properties. Our novel approach involves a one-step manufacturing method that can fabricate the superflexible fibrous tubular scaffold (SF-FTS) with topographical features via a modified electrospinning setup. We investigated the effect of humidity and temperature during the fabrication process on the formation of multiscale fibers. It was demonstrated that the incorporation of multiscale fibers and topographical features significantly enhances the mechanical properties of FTS. The mechanical advantages of SF-FTS were confirmed through the kinking resistance test, compressive test, and in vivo experiments. Additionally, we explored the interaction between the multiscale fibers and human umbilical vein endothelial cells (HUVECs) behavior. Our results suggest a novel strategy for fabricating FTS with advanced mechanical properties, and the designed SF-FTS holds promise as a potential candidate for clinical applications.
NOTES AND CORRESPONDENCE Relationship between Low-Level Jet Properties and Turbulence Kinetic Energy in the Nocturnal Stable Boundary Layer

Field: Earth and Planetary Sciences (Physical Sciences)

In the nighttime stable boundary layer (SBL), shear and turbulence are generated in the layer between the maximum of the low-level jet (LLJ) and the earth’s surface. Here, it is investigated whether gross properties of the LLJ—its height and speed—could be used to diagnose turbulence intensities in this subjet layer. Data on the height and speed of the LLJ maximum were available at high vertical and temporal resolution using the high-resolution Doppler lidar (HRDL). These data were used to estimate a subjet layer shear, which was computed as the ratio of the speed to the height of the jet maximum, and a jet Richardson number Ri J, averaged at 15min intervals for 10 nights when HRDL LLJ data were available for this study. The shear and RiJ values were compared with turbulence kinetic energy (TKE) values measured near the top of the 60-m tower at the Cooperative Atmosphere‐Surface Exchange Study-1999 (CASES-99) main site. TKE values were small for RiJ greater than 0.4, but as Ri J decreased to less than ;0.4, TKE values increased, indicating that Ri J does have merit in estimating turbulence magnitudes. Another interesting finding was that shear values tended to cluster around a constant value of 0.1 s 21 for TKE values that were not too small, that is, for TKE greater than ;0.1 m2 s 22.