jimnoneill/paper-to-field-training huggingface dataset:
Proactive Desk: New Haptic Interface and Its Experimental Evaluation

Field: Computer Science (Physical Sciences)

The Desk is a new human-machine interface for the desktop operations of computers. It provides users with tactile sensation in addition to visual sensation. Two linear induction motors underneath the desk generate a two-dimensional force to move objects and control their positions on the desktop using feedback control, and users feel tactile sensation while handling those objects. In this paper, we examined the effects of adding haptic information to simple mouse operation using the Proactive Desk. In our experiment, we used a button-type visual stimulus with and without haptic information. When using haptic conditions, three types of force feedback pattern were displayed: Edge, Resistance to motion and Attractive force, and each had three force strength conditions: no, half and full. The subject was asked to push buttons twenty times as the buttons were shown one after the other on the desk as quickly as possible. Consequently, the reaction times for pushing the button for all haptic conditions, except for the half-force condition of Attractive force, were significantly faster than no-force (without haptic information) condition. This result shows that the haptic information was advantageous for easy operation.
Severity of mitral regurgitation in mitral valve prolapse syndrome. A Doppler echocardiographic study.

Field: Medicine (Health Sciences)

Thirty-three consecutive patients with mitral valve prolapse with a systolic murmur were evaluated using pulsed doppler echocardiography to quantify the severity of mitral regurgitation. There were thirteen (39%) patients with mild regurgitation, twelve patients (36%) with moderate regurgitation and eight patients (24%) with severe regurgitation. It was noticed that, all the patients with severe regurgitation had posterior leaflet prolapse. In contrast, patients with anterior leaflet prolapse had either mild or moderate regurgitation only. Our results suggest that the degree of mitral regurgitation differs depending on the leaflet that shows the prolapse, which may be of importance in the followup of patients with mitral valve prolapse.
Heat Treatment Regulates Autophagy in C2C12 Myotubes

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Autophagy is a cellular process that allows for recycling of intracellular macromolecules and organelles. This process has been shown to be regulated by nutrient availability, with an upregulation in nutrient depleted conditions and a downregulation during nutrient excess. Prolonged heat stress has been shown to dysregulate autophagic signaling in skeletal muscle, leading to deleterious consequences. In contrast, exposure to short durations of heat (heat treatment) appears to have therapeutic effects. However, the impact of heat treatment on autophagy remains unknown. PURPOSE: To investigate the effects of an acute bout of heat treatment on autophagic signaling in skeletal muscle cells. METHODS: C2C12 myoblasts were grown and differentiated into myotubes. Following differentiation, cells were maintained at 37°C (thermal neutral; TN) or heated at 40°C (heat treatment; HT) for 1 or 2h. Heated cells were harvested immediately, 2h post-heating (recovery), or 24h recovery. Bafilomycin A1 (Baf, 100 nM), an autophagy inhibitor, was added to a subset of cells 3h prior to harvest. During recovery all cells were returned to 37°C. Cell lysates were analyzed via Western blot and densitometry. Statistical analysis of the data was performed by one-way analysis of variance (ANOVA) or an unpaired t-test, with α=0.05. RESULTS: One hour of HT increased the phosphorylation of AMPKT172 (64%, p<0.05) and the levels of LC3 II (29%, p<0.01) compared to TN cells. AMPK phosphorylation returned to baseline by 2h of recovery, while LC3 II remained elevated until 24h of recovery. When heat was extended to 2h, there was a similar increase in AMPK phosphorylation (56%, p<0.05), and a reduction in the phosphorylation of mTORS2448 (15%, p<0.01), without altering LC3 II. In the presence of Baf, 2h of HT increased p62 (62%, p<0.001) and LC3 II (75%, p<0.01) beyond HT alone. However, in 2h HT vs TN, the addition of Baf led to a reduction in LC3 II (24%, p<0.05) and a trend for increased phosphorylation of ULK1S555 (15%, p=0.08). CONCLUSION: Heat treatment of C2C12 cells increases signaling associated with the initiation of autophagy (increased p-AMPK, decreased p-mTOR) and phagophore formation (increased LC3 II). Additionally, we provide insight into the protective effect of heat treatment against the inhibition of autophagy.
Dataset related to article "Vessels Encapsulating Tumor Clusters (VETC) Is a Powerful Predictor of Aggressive Hepatocellular Carcinoma.

Field: Medicine (Health Sciences)

We investigated the clinical significance of a vascular growth pattern of hepatocellular carcinoma (HCC), the vessels that encapsulate tumor clusters (VETC), previously linked to HCC metastatic dissemination. VETC was assessed in a large multi-institutional cohort of 541 resected HCCs from Italy, Korea and Japan, and matched against a full spectrum of clinical and pathological variables. The VETC phenotype (defined as ≥ 55% tumor area by CD34 immunostaining) was easily reproducible and reliably detectable in whole sections and small-sized tissues of tissue microarray. VETC HCCs represented 18.9% of the whole series, the lowest proportion occurring in the cohort with smallest tumors (8.7%, Japanese series). VETC was significantly associated with several clinical and pathological features such as high alfa-fetoprotein (AFP) level, tumor size greater than 5 cm, poor differentiation, macrotrabecular pattern, less compact pattern, less inflammatory infiltrates, and frequent microvascular invasion. VETC was associated with early recurrence (hazard ratio [HR]: 1.52 [1.06-2.19], P = 0.023), disease-free survival (HR: 1.66 [1.21-2.27], P = 0.002), and overall survival (HR: 2.26 [1.37-3.72], P = 0.001) at multivariable analysis. VETC affected the survival in HCC patients stratified for etiology (hepatitis C virus/hepatitis B virus), vascular invasion, and specific molecular phenotypes (β-catenin/GS+). This distinct vascular pattern was enriched in the recently reported macrotrabecular massive HCC subtype, which was seen in 7.8% (42 of 541) of patients and associated with high AFP levels and poor differentiation. Conclusion: The VETC pattern was found to be easily detectable in a consistent fraction of HCC and a powerful pathological finding affecting survival. This study suggests that the heterogeneous pattern of angiogenesis is involved in HCC behavior.
Advanced Cyber Security Techniques for Data, Blockchain, IoT, and Network Protection

Field: Computer Science (Physical Sciences)

Advanced Cyber Security Techniques for Data, Blockchain, IoT, and Network Protection delves into the latest methods and strategies used by industry experts to secure complex digital environments. Whether fortifying blockchain frameworks, securing IoT devices, or protecting vast network infrastructures, this resource offers the cutting-edge insights necessary to stay one step ahead of cyber threats. This volume equips practitioners, academics, and policymakers with the knowledge to protect the digital frontier and ensure the safety and security of valuable assets
Seasonal Variations, Origin, and Parameterization of Ice‐Nucleating Particles at a Mountain Station in Central France

Field: Environmental Science (Physical Sciences)

Abstract Identifying how aerosol particles interact with atmospheric water is critical to understand climate and precipitation. Ice‐nucleating particles (INP) trigger the formation of atmospheric ice crystals at higher temperatures than pure water. They are difficult to characterize because of their scarce occurrence, and variability, in the atmosphere, especially at temperatures above −20°C. It has been demonstrated that at these temperatures, biological aerosol particles can contribute significantly to INP number concentration. This study incorporates a series of offline, size‐segregated measurements of INPs collected at the Puy de Dôme station (PUY, 1,465 m a.s.l.) over a 6 month period from October to May, covering the transitions from autumn, winter, to spring. These measurements show a general trend of decreasing particle number concentrations during the winter months and higher concentration during autumn and spring. INP concentrations measured in the range of −5 and −18°C, had concentrations of 0.001 INP/L air at the warmest temperatures, and between 0.01 and 0.1 INP/L air at the coldest temperatures. The majority of INP measured at temperatures warmer than −15°C were heat labile, suggesting a biological or organic origin. The INP variability was compared with collocated aerosol physical and chemical properties, allowing us to associate highest INP concentrations with local and marine origins. Following these comparisons, we use aerosol total number concentration to develop a new parameterization. In addition, this parameterization is specifically optimized for warmer temperature INP measurements, and demonstrated a good performance when tested on independent data sets.
Implementation and Validation of a Novel and Inexpensive Training Model for Laparoscopic Inguinal Hernia Repair

Field: Health Professions (Health Sciences)

Purpose: The aim of this study was to develop and validate a reproducible low-cost model useful for the development and acquisition of skills and competencies required for endoscopic hernia repairs. Methods: Ten general surgery residents (PGY3) were instructed to construct the model and perform the maneuvers necessary for the simulation of laparoscopic inguinal hernioplasty by the trans -abdominal pre-peritoneal (TAPP) technique. They practiced for 4 weeks in the model, and the time required to perform simulated hernioplasty by the laparoscopic TAPP technique in the initial session was compared to the time required after 4 weeks of training. Results: The time required to perform the exercise was significantly lower than in the initial session ( p < 0.01). The time required by residents to complete the exercise in the initial session was significantly longer than that used by expert surgeons in the same task ( p < 0.01), and although a significant difference persisted, this difference was substantially reduced to 3.60 min after the residents completed 4-week training in the model ( p < 0.01). An independent expert, blinded to the level of training of the person who performed the exercise, could recognize all residents as novices and all experienced surgeons as experts in the initial session of the exercise with the model, but after 4 weeks of training, they did not recognize 4 of the 10 residents as novices ( p < 0.05). Conclusion: The routine implementation of training in this model could be very useful in the laparoscopic inguinal hernioplasty teaching-learning process.
The impact of own-country, US and China's Economic Policy Uncertainty on Stock Market Returns: Evidence from war, epidemic and financial crisis periods

Field: Economics, Econometrics and Finance (Social Sciences)

The question of the economic policy uncertainty (EPU) and its effects on the stock market returns in shock periods is rarely addressed by the literature. Thus, we are motivated to provide new insights into the study of these effects based on dynamic panel data for own-country, USA and China's economic policy uncertainty over the period 2000Q1 to 2019Q4. These effects are also re-examined in the epidemic, war and financial crisis periods. Indeed, our empirical results show that the nexus between EPU and stock market returns is negative and statistically significant for own-country and has a mixed significant effect for the USA and China. Moreover, the epidemic, war, and financial crisis reduce the negative effects and raise the positive one of EPU on stock market returns in different countries.
A new large projection operator for the redundancy framework

Field: Computer Science (Physical Sciences)

In this paper, we propose a new projection operator for the redundancy framework based on a task function defined as the norm of the usual error. This projection operator allows performing secondary tasks even when the main task is full rank. To ensure the convergence of the system, a switching strategy is then defined to switch from the new projection operator to the classical one before the norm of the total error reaches zero. An adaptive gain is also defined to slow down the convergence of the main task. It allows the secondary tasks to be active for longer. The experimental results obtained show the agreement with the analytical study and demonstrate the effectiveness of the proposed projection operator with respect to the classical one.
Immunomodulators and immunosuppressants in the era of SARS-CoV-2 – could laboratory tests be the missing link?

Field: Medicine (Health Sciences)

"Immunomodulators and immunosuppressants in the era of SARS-CoV-2 – could laboratory tests be the missing link?." Journal of Dermatological Treatment, 31(5), pp. 439–440 Disclosure statementNo potential conflict of interest was reported by the author(s).
ERIC ED353701: Break the Fast: A Guide for School Breakfast Programs.

Field: Health Professions (Health Sciences)

Guidelines for implementing and operating a school breakfast program in New York are provided in this document. Following an introduction that explains the need for school breakfast programs, sections describe program history, meal pattern requirements, eligible participants, and available state and local financial assistance. Program requirements are described for the approval procedure; nutrition standards and pupil service; reports and records; and food service operation and supervision. Recommendations are made for increasing parent and student involvement. The next section examines perceived barriers to breakfast programs and concludes that a program can be run without causing major disruption if commitment is high. Strategies for merchandizing the program are described in the next section. The conclusion notes that the correlation between breakfast and good health, development, and educational performance makes school breakfast programs a priority. Answers to 15 commonly asked questions are provided in the final section. The appendix contains school breakfast meal patterns, sample menus, forms for student and parent surveys, an outline of a speech to a parent group, and sample news release. (LMI)
In vitro alteration of receptors for vasoactive intestinal peptide changes the in vivo localization of mouse T cells

Field: Immunology and Microbiology (Life Sciences)

The capacity of T lymphocytes exposed in vitro to the neuropeptide vasoactive intestinal peptide (VIP) to bind VIP in vitro and to migrate to different tissues in vivo has been studied. VIP treatment of T cells resulted in a time- and dose-dependent loss of the ability of T cells to specifically bind radioiodinated VIP. Altered binding was due to a decrease in the expression of cellular receptors for VIP on the treated cells rather than an alteration in the affinity of the cells for the neuropeptide. Alteration of VIP receptor expression was not associated with a change in the expression of Thy-1, Lyt-1, or Lyt-2 surface markers by the treated cells. VIP treatment of T cells in vitro resulted, however, in a dose-dependent decrease in the ability of the treated cells to localize in mesenteric lymph nodes (MLN) and Peyer's patches of recipient animals at early times after cell transfer, and this was due to a selective decrease in the rate of accumulation of the treated cells in these tissues. There was no alteration in the distribution of VIP-treated cells in the blood, spleen, liver, or other major organs of the recipient animals. It is concluded that the presence of VIP receptors on T cells facilitates the entry of T cells into MLN and Peyer's patches in vivo, and it is proposed that this effect is mediated by T cell-VIP interactions in the vicinity of the specialized endothelium of those tissues.
Determination of Load-Sharing Displacement of Flexible Pin Roll in Planet Gear Train

Field: Engineering (Physical Sciences)

The eccentricity errors of each piece in the planet gear train set are described. This paper has made a tentative study on the determination of load-sharing displacement with formulas of equivalent errors. It takes the flexible pin roll as the load-sharing piece and LevelⅡ planet gear drive in the speed-increasing gearbox of some wind power generator for the case study. The results show i) that the radial error of each piece does not influence the operation of the planet gear train, but the tangential error does influence the load-sharing among the planet gears; and ii) that the load sharing displacement is determined by the centering tangential equivalent error of the flexible pin roll, which may provide reference to projects.
Kerouac, the Word and the Way: Prose Artist as Spiritual Quester

Field: Arts and Humanities (Social Sciences)

Book Review| September 01 2001 Kerouac, the Word and the Way: Prose Artist as Spiritual Quester By Ben Giamo. Carbondale: Southern Illinois Univ. Press. 2000. xxi, 246 pp.$39.95. D. Quentin Miller D. Quentin Miller Search for other works by this author on: This Site Google American Literature (2001) 73 (3): 647–648. https://doi.org/10.1215/00029831-73-3-647 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation D. Quentin Miller; Kerouac, the Word and the Way: Prose Artist as Spiritual Quester. American Literature 1 September 2001; 73 (3): 647–648. doi: https://doi.org/10.1215/00029831-73-3-647 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsAmerican Literature Search Advanced Search The text of this article is only available as a PDF. 2001 Article PDF first page preview Close Modal You do not currently have access to this content.
How Discriminative Are Your Qrels? How To Study the Statistical Significance of Document Adjudication Methods

Field: Computer Science (Physical Sciences)

Creating test collections for offline retrieval evaluation requires human effort to judge documents' relevance. This expensive activity motivated much work in developing methods for constructing benchmarks with fewer assessment costs. In this respect, adjudication methods actively decide both which documents and the order in which experts review them, in order to better exploit the assessment budget or to lower it. Researchers evaluate the quality of those methods by measuring the correlation between the known gold ranking of systems under the full collection and the observed ranking of systems under the lower-cost one. This traditional analysis ignores whether and how the low-cost judgements impact on the statistically significant differences among systems with respect to the full collection. We fill this void by proposing a novel methodology to evaluate how the low-cost adjudication methods preserve the pairwise significant differences between systems as the full collection. In other terms, while traditional approaches look for stability in answering the question "is system A better than system B?", our proposed approach looks for stability in answering the question "is system A significantly better than system B?", which is the ultimate questions researchers need to answer to guarantee the generalisability of their results. Among other results, we found that the best methods in terms of ranking of systems correlation do not always match those preserving statistical significance.
Effect of altitude exposure on platelets

Field: Medicine (Health Sciences)

Since decompression from depth is known to produce a fall in platelet count, the effect of altitude decompression and high-altitude exposure on platelets was investigated. Sixteen subjects decompressed without hypoxia to 20,000 ft simulated altitude for two hours showed a significant (P less than 0.01) drop in circulating platelet count of approximately 10% for three days following decompression. Four of five subjects similarly exposed had a shortened autologous platelet survival compared to that prior to exposure. Subjects exposed to 9,800 ft and then 17,600 ft in a mountain environment showed a significant mean decrease in platelet count on day 2 of 7% and 25% respectively, which had returned to control by day 5. Nonhypoxic and hypoxic decompressed rabbits which received homologous chromium-51-labeled platelets had an increase in lung radioactivity compared with sea-level controls. It is postulated that altitude decompression produces platelet reductions similar to these seen after decompression from depth, and that platelets sequester in the pulmonary vascular bed.
Tax Sovereignty and International Tax Reform: The Author's Response

Field: Economics, Econometrics and Finance (Social Sciences)

Nothing quite compares to the exhilaration that an author feels when her work is being reviewed by her peers. I was f lattered by the reviews of my book by Dov Begun, Arthur Cockfield, and Niv Tadmore. I now face the challenge of replying to some of the interesting issues raised by them. I thank Neil Brooks for giving me this opportunity to write a brief response. Begun reviews the book and nicely captures its thesis. I thank him for that. Cockfield and Tadmore each focus their respective comments on one particular aspect of the book: Cockfield takes me to task on my support for global formulary allocation of business profits, and Tadmore expands my analysis of income characterization. All three reviews touch on the issue of tax enforcement. After reading their comments, I wished that I had had another year to complete the book. On the assumption that many readers have not yet read the book, I will first summarize its main arguments and then address the issues of income characterization, administrative constraints on tax reform, and national sovereignty. I will focus on the sovereignty question because a high level of international coordination is critical to any international tax reform.
PARTICLE CHARACTERIZATION AT RURAL, SUBURBAN AND URBAN AEROSOL SAMPLING SITES IN HUNGARY

Field: Environmental Science (Physical Sciences)

The study of atmospheric aerosols originating from natural and anthropogenic processes is of basic importance for a detailed understanding of the physics and chemistry of the atmosphere. Particle Induced X-ray Emission (PIXE) technique has been used by the authors for studying regularly the elemental composition of rural, suburban, and urban aerosols collected at six sampling sites in Hungary. Observed data presented in terms of concentrations and regional signature values and evaluated wind sector partition and in transport modelling revealed the natural/anthropogenic contribution to the moderate air pollution here. Dry deposition velocities have been deduced for elements V, Cr, Mn, Co, Ni, Cu, Zn, Cd, and Pb. Model calculations based on annual emission data and observed elemental concentrations resulted in total dry and wet deposition masses of the above elements to the territory of the country. At the same time, deduced budget data for the emission and deposition of the constituents indicated whether the country represents a net source or a sink for the above mentioned elements in the regional aerosol transport between neighbouring countries. Evidences have been found for intrusion events of Saharan aerosol to the atmosphere of Hungary. Part of the data collected recently will be evaluated in the frame-work of an international co-ordinated research programme.