jimnoneill/paper-to-field-training huggingface dataset:
SAGUARO (CARNEGIEA GIGANTEA, CACTACEAE) GROWTH RATE OVER ITS AMERICAN RANGE AND THE LINK TO SUMMER PRECIPITATION

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Using an index of saguaro (Carnegiea gigantea) growth rate, relative growth was compared among multiple saguaro populations and mapped across the American range of the species. Relative growth at 10 sites was strongly linked to summer precipitation. This is the first study of relative growth and the first to link growth rate to environmental variables in multiple populations. Resumen Usando un indice de la tasa de crecimiento del saguaro (Carnegiea gigantea), se comparo el crecimiento relativo entre poblaciones multiples de saguaro y se ilustro a traves del rango americano de la especie. El crecimiento relativo en 10 sitios fue fuertemente ligado a la precipitacion de verano. Este es el primer estudio de crecimiento relativo y el primero en ligar la tasa de crecimiento a variables ambientales en poblaciones multiples.
Phase Locked Loop based Resonator Driving IC with Negative Charge Cancelling

Field: Engineering (Physical Sciences)

This paper presents a low power resonator driving IC for nano-resonator. To reduce power consumption and phase distortion, the resonator driving IC consists of a phase locked loop (PLL) structure. Using the inverter-based negative charge cancelling method, the parasitic capacitor is removed in a simple structure with low power consumption. The proposed resonator driving IC consists of a charge pump phase frequency detector (CPPFD), voltage-controlled oscillator (VCO), trans impedance amplifier (TIA), comparator, inverter and negative capacitor. The TIA is composed of the Monticelli class AB structure to improve power efficiency. The proposed PLL based resonator driving IC is implemented in a 180 nm 1P6M CMOS technology and the power consumption of the proposed resonator driving IC is 2.17 mW with 1.8 V supply. When driving a resonator with a resonance frequency of 7.2 MHz and a Q-factor of 50, the proposed PLL based resonator driving IC has a resonance frequency of 7.26 MHz, a Q-factor of 103,863 amplified by 20000 times and a phase noise of −83 dBc/Hz at 10 kHz offset.
Obinutuzumab‐induced acute thrombocytopenia: Report of two cases and review of literature

Field: Medicine (Health Sciences)

Summary Obinutuzumab (GA101) is a humanized anti‐CD20 monoclonal antibody used in the treatment of B‐cell malignancies. Under rare occasions, obinutuzumab may induce acute and severe thrombocytopenia. However, little is known about this side effect, referred to as “obinutuzumab‐induced acute thrombocytopenia” (OIAT). Here, we report 2 cases of OIAT and review the literature to inform the management and outcome of this rare but life‐threatening complication. The first case is a 74 year‐ old woman who was treated with obinutuzumab‐Cyclophosphamide, Vincristine, Prednisone (CVP) for a previously untreated follicular lymphoma. This patient experienced an acute thrombocytopenia with a drop in her platelet count from 376 G/L to 3 G/L the day after treatment. The second case is a 44 year‐ old woman who was treated with obinutuzumab as a pre‐treatment dose (day‐8) before glofitamab infusion as a 4th line therapy for mantle cell lymphoma. This patient experienced an acute thrombocytopenia with a drop in her platelet count from 76 G/L (due to splenomegaly and bone marrow involvement) to 3 G/L the day after treatment. OIAT is a rare but life‐threatening complication. Physicians should be aware of this adverse event to optimally detect and treat this complication.
Induction of Chronic Lymphocytic Leukemia (CLL) Apoptosis by Nitric Oxide Synthase (NOS) Inhibitors: Drug Efficacy Correlates with Lipid Solubility and NOS1 Dissociation Constant.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract The viability of CLL cells may be dependent on the autocrine production of nitric oxide because nitric oxide synthase (NOS) inhibitors induce CLL cell apoptosis and CLL cells express inducible NOS (NOS2). Our previous study indicated that the non-specific NOS inhibitor NMMA induced CLL cell apoptosis but only at high concentrations (&gt; 1 mM) (Levesque et al., Leukemia17:442, 2003). Therefore, we performed the current study to identify NOS inhibitors that induce CLL cell apoptosis at lower concentrations and to understand factors that promote NOS inhibitor-induced CLL cell toxicity. We isolated and enriched CLL cells from the blood of CLL patients and cultured the CLL cells in media containing various concentrations of 21 different NOS inhibitors. We determined CLL cell viability following culture with each NOS inhibitor. We found that NOS inhibitors with specificity for neuronal NOS (NOS1) induced CLL cell death at concentrations lower than non-specific NOS inhibitors and lower than inducible NOS (NOS2) specific inhibitors. There was a weak correlation (r2 = 0.29, p = 0.1608) of the NOS1 (but not NOS2) half-maximal inhibitory concentration (IC50) of each NOS inhibitor for purified recombinant NOS and its ability to induce CLL cell death. We confirmed the specificity of the NOS inhibitors by inhibition of purified recombinant NOS1 and NOS2 enzyme activity, and we confirmed that NOS1 specific inhibitors induced CLL cell death by apoptosis. Because there was only a weak correlation of the NOS1 IC50 with NOS inhibitor induced CLL cell death, we considered whether other factors such as the Kd and hydrophobicity of each compound correlated with CLL cell death. We found that there was a direct correlation between the NOS1 (but not NOS2) dissociation constant (Kd) of NOS inhibitors and CLL cell death (r2 = 0.77, p = 0.0041) and a direct correlation of the partitioning coefficient (a measure of hydrophobicity) of each NOS inhibitor and its ability to induce CLL cell death (r2 = 0.68, p &lt; 0.0001). Therefore, NOS inhibitors that bound tightly to NOS1 and were hydrophobic induced CLL cell death at lower concentrations. There was variable expression of CLL cell NOS1 mRNA (6 of 28 samples positive) and we were unable to demonstrate CLL cell expression of NOS1 protein by immunoblotting. This suggests that if NOS1 is present in CLL cells, it exists at very low levels. Taken together, we believe that low level NO production promotes CLL cell viability and that inhibition of CLL NOS induces CLL cell apoptosis. Importantly, our studies provide direction for the rational design and selection of NOS inhibitors that may be useful as CLL therapeutics.
Novel Method for Investigating Broadband Velocity Fluctuations in Axisymmetric Screeching Jets

Field: Engineering (Physical Sciences)

The noise spectrum of screeching jets consists of broadband and discrete components referred to as turbulent mixing noise and screech tones, respectively. The screech tones make the application of classical noise models to screeching jets difficult for modern problems. These problems involve an additional treatment of the near-field dynamics before the broadband noise prediction schemes can be implemented. This paper proposes an a posteriori approach for studying the velocity fluctuations associated with the broadband turbulent mixing noise in screeching jets. The broadband and screeching fluctuations associated with the broadband and discrete noise components are calculated using proper orthogonal decomposition to decouple the velocity variables. The methodology is demonstrated on velocity fields of screeching jets measured with high-resolution particle image velocimetry. Jets dominated by the precessing flapping (B) and helical (C) instability screech modes are considered, which correspond to ideally expanded Mach numbers of , 1.45, and 1.59, respectively. Axially averaged spatial wavelength spectra of the broadband velocity fluctuations are compared to illustrate the decomposition. The proper-orthogonal-decomposition-based approach is shown to be highly dependent upon the dominant instability regime of the jets. Further analysis shows that the integral length scales of the broadband velocity fluctuations normalized by the incompressible momentum thickness in the screeching jets considered agree well with values reported in studies on nonscreeching jets despite the absolute values differing.
A framework for assessing the psychologic functioning of adolescents.

Field: Psychology (Social Sciences)

Pediatricians are often the first professionals consulted by families concerned that their teenagers may be experiencing emotional distress. Assessing the meaning of psychologic symptoms in adolescents can be a difficult task. The physician is frequently called upon to determine if an adolescent's difficulties fall within the spectrum of normative behavior or whether psychopathology is present which demands therapeutic intervention. In making this decision, the pediatrician must conduct an evaluation which considers multiple clinical factors. This report presents a framework for the pediatrician in evaluating the psychologic functioning of adolescent patients.
DC Potentials of the Membranous Labyrinth

Field: Neuroscience (Life Sciences)

The endolymphatic DC potentials were measured in the utricle, saccule and cochlear duct of the membranous labyrinth of the guinea pig and compared with potassium analyses of the endolymph. The average utricular potential was found to be +4 mv, the saccular potential +1 mv, and the cochlear potential +65 mv. The average potassium concentration of utricular endolymph was 139 mEq/l.; that from the cochlea was similar. The cochlear DC potential is approximately 70 mv higher than that of the vestibule (utricle and saccule), whereas the high potassium and low sodium concentration of endolymph is similar throughout. It is concluded that the endolymphatic resting potential of the internal ear is not correlated with the potassium or the sodium concentration of the endolymph.
Innovative Research of Librarian Service Model in University Based on the Needs of Readers

Field: Social Sciences (Social Sciences)

Readers'demand is the driving force of library development, the ultimate goal of library services is to provide timely and accurate information services.Ideal subject service should be based on the needs of readers, go deeply into teaching, research and learning of users, provide professional and individualized value-added information services anytime and anywhere.We treat readers' needs as core guide, explore university library how to conduct service innovation of librarian on the basis of readers' needs.
Risk factors associated with periprosthetic joint infection after total elbow arthroplasty

Field: Medicine (Health Sciences)

Background For patients undergoing total elbow arthroplasty (TEA), the present study aimed to investigate: (i) what risk factors are associated with periprosthetic elbow infection; (ii) what is the incidence of infection after TEA; and (iii) what is the acuity with which these infections present? Methods The Statewide Planning and Research Cooperative System database was used to identify all patients who underwent TEA between 2003 and 2012 in New York State. Admissions for prosthetic joint infection (PJI) were identified using ICD-9 (International Classification of Diseases, Ninth Revision, Clinical Modification) diagnosis code 996.66. Multivariate analysis was used to determine risk factors that were independently prognostic for PJI. Results Significant risk factors for PJI included hypothyroidism [odds ratio (OR) = 2.04; p = 0.045], tobacco use disorder (OR = 3.39; p = 0.003) and rheumatoid arthritis (OR = 3.31; p < 0.001). Among the 1452 patients in the study period who underwent TEA, 3.7% ( n = 54) were admitted postoperatively for PJI. There were 30 (56%) early infections, 17 (31%) delayed infections and seven (13%) late infections. Conclusions Pre-operative optimization of thyroid function, smoking cessation and management of rheumatoid disease may be considered in surgical candidates for TEA. The results of the present study add prognostic data to the literature that may be helpful with patient selection and risk profile analysis. Level of evidence Level III: prognostic study
Effect of Milk or Soybean Milk Intake on Blood Lipid And Glucose in Healthy Young Men

Field: Medicine (Health Sciences)

Objective To study the effect of milk or soybean milk intake on blood lipid and glucose in healthy young men.Methods 30 male undergraduate students were randomly divided into milk group,soybean milk group and pure water group.Each group was required to consume the corresponding drinks 1L per day,continuously for four weeks.The levels of triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and glucose(GLU) were determined before and after the intervention.Results The level of LDL-C decreased from 2.28±0.33 mmol/L to 1.95±0.41 mmol/L(P﹤0.05)in the milk group,and from 2.23±0.27 mmol/L to 1.94±0.37 mmol/L in the soyabean milk group(P﹤0.05).Compared with the pure water group,the level of LDL-C in the milk group and soybean group decreased significantly(P﹤0.01).In addition,the level of triglyceride also decreased significantly in the soya bean milk group(P﹤0.05).The level of TC and GLU in all the groups did not change significantly.Conclusions Drinking milk or soybean milk has no significant effect on blood glucose,but is effective on lowing blood lipid,thus preventing cardiovascular disease such as atherosclerosis.
DataSpace: querying and monitoring deeply networked collections in physical space

Field: Computer Science (Physical Sciences)

We introduce a new conception of three-dimensional DataSpace, which is physical space enhanced by connectivity to the network. DataSpace is addressed geographically as opposed to the current logical addressing scheme of the Internet. Here, a local area network is replaced by a room, a street, a mountaintop, and so on. Billions of objects populate DataSpace, each aware of its own geographic location. These objects move through DataSpace, and produce and locally store their own data. They can be selectively queried, monitored, and controlled based on their properties. We propose two architectures for DataSpace. We describe mechanisms to use the network as a DataSpace engine in order to perform querying and monitoring operation in a highly scalable way.
“Theologization” of Psychology and “Psychologization” of Religion: How Do Psychology and Religion Supposedly Contribute to Prevent and Overcome Social Conflicts?

Field: Psychology (Social Sciences)

This study assumes that indigenous epistemological comprehension of social conflict and violence is at the heart of social protection. The authors aim to explain that there are two symptoms developing in Indonesia, i.e. "Psychologization" of religion and "theologization" of psychology. We conducted this research to map the symptoms by inviting resource person from religionist and psychological scientist circle. We asked five religious figures, where one of them is a Christian and the others are Moslems, regarding how theology should address psychology and vice versa, as well as its relation to the democratization of violence. We also inquire two psychologists regarding how psychology should address religion in the context of understanding and social intervention against social conflict and violence, and conversely, how theology should place psychology in this context. We concluded that if we managed to put psychology and theology in their place respectively, then the research projects and intervention can be more precise and just in formulating existing issues, as well as more optimistic expectations of the research results applicability in the field in order to build and maintain peace in Indonesia. Thereby, we can expect the nation's socio- economic competitiveness to be maintained and even accelerated.
DAILY DYNAMICS OF SEXUAL HUNTING SIGNS IN COWS AND HEIFERS OF MATING AGE OF DAIRY HERD WITH LOOSE HOUSING

Field: Agricultural and Biological Sciences (Life Sciences)

The article reveals the feasibility of organizing and conducting the selection of cows and heifers by sexual activity for artificial insemination day and night. Revealed for three months in females (n=717): in 600 signs of sexual activity in 0,70 %, 700-19,94 %; 800- 19,25 %; 900 – 9,21 %; from 1000-1200-14.78 %; from 1300-1400- 4.32 %; from 1500-1600-15.2 %; from 1700-1900 – 9,76 %; 2000-6,83 %. It was revealed that most animals had sexual activity in the morning (49.10 %). In August, 213 heads were studied, of which the signs of sexual activity in 600 had 2.35 %; in 700-14.08 %; in 800 - 11.74 %; in 900 - 8.45; in 1000 decreased to 3.29 %, in 1400 - an increase to 11.74 %; in 1600 - 12.68 %; in 1800 - 13.15% and 2000 - 22.54 %. Round-the-clock monitoring revealed a state of libido, for a period of 0000-400 hours morning 25,00 %, 400-800 – 18,27 %, 800-1200 – 17,34 %, 1200-1600 – 20,19 %, 1600-2000 – 4,81 %, 2000-2400 - 14,42 %. Of the 104 cows identified in the hunt, 62.5 % showed sexual activity in the period from 2000 to 800, and only 37.5 % of cows in the hunt were detected during the working hours of the artificial insemination operator. Also, from 22 heifers, 40.9 % showed signs of sexual activity in the period from 2000 to 800, and 59.09 % showed signs of sexual activity during working hours. Therefore, given the acceleration of physiological processes in the warm season, there are prerequisites for reducing the efficiency of the operator. In September (an hour later), it was revealed in females (n=270): in 700 - 18.89 %, in 800 - 21.85 %; before 900 there was a decrease to 1000 %; and by 1000 hours - a rapid increase to 27.04 %; by 1400, a decrease to 1.85 %; from 1600 to 2000 - 12.96, 7.04 and 0.37 %, respectively. In October, out of 234 animals in 700, 26.50 % of females showed signs of sexual activity, which is 7.60 more than in September and 12.42 % more than in August; in 800 - 23.08 %; in 900-8.97 %; in 1000, a slight increase to 11.11 % was observed, by 1400 - a decrease to 0.43 % (similar to the previous month); in 1600, 20.09 % were detected, in 1800 - 9.83 %. So, during the daylight hours, cows and heifers show signs of sexual activity not evenly: the first wave of excitement begins with a sunrise and lasts 4-6 hours, the second begins at 1400-1600 and continues until sunset. The data obtained indicate that it is advisable to identify cow’s sexual activity both during the day and at night. Such studies should be carried out depending on the time of year: the length of daylight and the temperature of the environment. The conducted research can serve as a basis for compiling the multiplicity of detection of cow’s sexual activity during the day and the mode of their detection libido during working shifts by artificial insemination operators, their assistants and other workers.
Neurological basis of phonological/articulatory loop.

Field: Neuroscience (Life Sciences)

作業記憶の下位システムである音韻性 (構音性) ループは,言語性の短期記憶 (STM) から発展した概念であり,内容的にはほぼ同一である。心理学領域,神経心理学領域のさまざまな知見から,音韻性ループの細分化の必要性が生じ,Vallerらは入力側の要素として音韻性短期貯蔵庫,出力側の要素として音韻性出力バッファーをそのモデルのなかに加えた。主として伝導失語からなる脳損傷例のdigit spanの結果から,このモデルの神経解剖学的基盤を検討した。音韻性短期貯蔵庫は上側頭回に,音韻性出力バッファーは中心前回に,音韻性ループは両者を結ぶ頭頂葉に,おのおの対応するとの仮説を提示した。今後は,健常者を対象としたPET賦活研究やfunctional MRIによる知見の集積が期待され,これらの研究と病巣研究が互いの欠点を補完しあうことが期待される。
Effectiveness of Educational Program on Nurses’ Knowledge and Performance Regarding Shift Change Handoff and Its Effect on Continuity of Patient Care

Field: Health Professions (Health Sciences)

Background: Handoff is a vital step in nursing care, particularly in critical care units, because it involves the transfer of clear and simple patient clinical information that leads to enhanced continuity of patient care.Aim of the study: Assess effectiveness of educational program on nurses' knowledge and performance regarding shift change handoff and its effect on continuity of patient care.Design: A quasi experimental research design was used to carry out this study.Setting: The research was carried out in Intensive Care Units at Benha Teaching Hospital.Subjects: All available 48 nurses.Tools for data collection: Three tools were used for data collection namely; Handoff Knowledge Questionnaire, Handoff Observational Checklist, Continuity of Care Observational Checklist.The results showed that, there was highly statistically significant improvement in nurses` knowledge and performance regarding handoff at post, follow up program than preprogram.Also there was highly statistically significant improvement in level of continuity of care post program, follow up as majority of nurses has satisfactory level of continuity of care (83.3%, 85.4%) compared to preprogram (25.0%).Conclusion: Implementing the educational program had a significant effect in improving nurses' knowledge and performance of handoff, as well as total continuity of care during the post-program phase.There was a highly statistically significant positive correlation between total knowledge, total performance regarding handoff, and total continuity of care among nurses post-program scores.The study recommended that: Conducting continuous in-service workshops about intradepartmental communication among nurses through hospital continuous training and learning center
Mutation Status and Burden Can Improve Prognostic Prediction of Patients with Lower-Risk Myelodysplastic Syndromes

Field: Medicine (Health Sciences)

Patients with lower-risk myelodysplastic syndromes (LR-MDS) as defined by the International Prognostic Scoring System (IPSS) have more favorable prognosis in general, but significant inter-individual heterogeneity exists. In this study, we examined the molecular profile of 15 MDS-relevant genes in 159 patients with LR-MDS using next-generation sequencing. In univariate COX regression, shorter overall survival (OS) was associated with mutation status of ASXL1 (P=0.001), RUNX1 (P=0.031), EZH2 (P=0.049), TP53 (P=0.016), SRSF2 (P=0.046), JAK2 (P=0.040), and IDH2 (P=0.035). We also found significantly shorter OS in patients with a TET2 variant allele frequency (VAF) ≥18% versus those with either a TET2 VAF <18% or without TET2 mutations (median: 20.4 vs. 47.8 months; P=0.020; HR=2.183, 95%CI: 1.129-4.224). After adjustment for the IPSS, shorter OS was associated with mutation status of ASXL1 (P<0.001; HR=4.306, 95%CI: 2.144-8.650), TP53 (P=0.004; HR=4.863, 95%CI: 1.662-14.230) and JAK2 (P=0.002; HR=5.466, 95%CI: 1.848-16.169), as well as a TET2 VAF ≥18% (P=0.008; HR=2.492, 95%CI: 1.273-4.876). Also, OS was increasingly shorter as the number of mutational factors increased (P<0.001). A novel prognostic scoring system based on the IPSS and the presence/absence of the 4 independent mutational factors further stratified LR-MDS patients into three prognostically different groups (P<0.001).The newly developed scoring system re-defined 10.1% (16/159) of patients as higher-risk group, who could not be predicted by the currently prognostic models. In conclusion, integration of IPSS with mutation status/burden of certain MDS-relevant genes may improve the prognostication of patients with LR-MDSand could help identify those with worse-than-expected prognosis for more aggressive treatment. Figure Disclosures No relevant conflicts of interest to declare.