jimnoneill/paper-to-field-training huggingface dataset:
OYGEN DEPENDENCE AND REPAIR OF LETHAL EFFECTS OF NEAR ULTRAVIOLET AND VISIBLE LIGHT*

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract— –Lethality in a repairable strain (WP2) and an excision repair deficient strain (WP2h cr ) of Escherichia coli was studied at wavelengths of 254, 313, 365, and 390–750 nm. Survival curves were empirically fitted to the expression S = 1 ‐ (1‐e ‐kl )“, where S is the fraction surviving, D is the incident dose in ergs mm ‐2 , k is the inactivation constant in units of (erg mm ‐2 ) ‐1 and n is the ‘shoulder constant’. The repairable sector ( k (hcr ‐ )– k ( hcr ‐ ) lk ( hcr ‐ ), a conservative estimate of the repair capability of E. coli WP2, was 0.91 at 254 nm, 0.92 at 313 nm, 0.60 at 365 nm, and 0.13 at 390–750 nm. Although there was no oxygen enhancement of inactivation at 254 nm and 313 nm, a strong enhancement was identified at 365 nm and 390–750 nm. These results suggest that oxygen‐dependent damage induced by near u.v. (365 nm) can be partially repaired by the excision‐repair system in E. coli.
Tubulin Inhibitors Targeting the Colchicine Binding Site: A Perspective of Privileged Structures

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The vital roles of microtubule in mitosis and cell division make it an attractive target for antitumor therapy. Colchicine binding site of tubulin is one of the most important pockets that have been focused on to design tubulin-destabilizing agents. Over the past few years, a large number of colchicine binding site inhibitors (CBSIs) have been developed inspired by natural products or synthetic origins, and many moieties frequently used in these CBSIs are structurally in common. In this review, we will classify the CBSIs into classical CBSIs and nonclassical CBSIs according to their spatial conformations and binding modes with tubulin, and highlight the privileged structures from these CBSIs in the development of tubulin inhibitors targeting the colchicine binding site.
KINERJA INDIVIDU KEMAMPUAN TEKNIK PERSONAL DAN KINERJA KARYAWAN: EFEKTIVITAS SISTEM INFORMASI AKUNTANSI SEBAGAI VARIABEL INTERVENING

Field: Business, Management and Accounting (Social Sciences)

Abstract— The purpose of this study is to find out the influence between Individual Performance and Personal Engineering Capabilities on Employee Performance with the Effectiveness of Accounting Information System as Intervening Variable in BPKAD Blitar Regency. Accounting information system can be said to be effective depending on how well the user is able to use the application and know well what is contained in the system, therefore it takes individual performance and good personal engineering skills from employees. Individual performance and personal engineering capabilities are expected to encourage the performance of BPKAD employees in Blitar Regency through the effectiveness of accounting information system in carrying out the work that the organization charges them. The population in this study was 45 employees and a sample of 30 employees as respondents determined using purposive sampling method. The data collection in this study used questionnaires. The data was analyzed using Partial Least Square (PLS) assisted by the Smart PLS 3.0 application. The results of this study showed that individual performance and personal engineering capabilities had no effect on the effectiveness of BPKAD accounting information system in Blitar Regency. Individual performance has no effect on the performance of BPKAD employees in Blitar Regency. The ability of personal techniques and the effectiveness of accounting information systems affects the performance of BPKAD employees in Blitar Regency, it can be interpreted that the higher the ability of personal techniques and the effectiveness of information systems will improve the performance of BPKAD employees in Blitar Regency at work. Keywords: Individual Performance; Personal Engineering Capabilities; Employee Performance; Effectiveness of Accounting Information System
Modeling and integration of N-glycan biomarkers in a comprehensive biomarker data model

Field: Computer Science (Physical Sciences)

Abstract Molecular biomarkers measure discrete components of biological processes that can contribute to disorders when impaired. Great interest exists in discovering early cancer biomarkers to improve outcomes. Biomarkers represented in a standardized data model, integrated with multi-omics data, may improve the understanding and use of novel biomarkers such as glycans and glycoconjugates. Among altered components in tumorigenesis, N-glycans exhibit substantial biomarker potential, when analyzed with their protein carriers. However, such data are distributed across publications and databases of diverse formats, which hamper their use in research and clinical application. Mass spectrometry measures of 50 N-glycans on 7 serum proteins in liver disease were integrated (as a panel) into a cancer biomarker data model, providing a unique identifier, standard nomenclature, links to glycan resources, and accession and ontology annotations to standard protein, gene, disease, and biomarker information. Data provenance was documented with a standardized United States Food and Drug Administration-supported BioCompute Object. Using the biomarker data model allows the capture of granular information, such as glycans with different levels of abundance in cirrhosis, hepatocellular carcinoma, and transplant groups. Such representation in a standardized data model harmonizes glycomics data in a unified framework, making glycan–protein biomarker data exploration more available to investigators and to other data resources. The biomarker data model we describe can be used by researchers to describe their novel glycan and glycoconjugate biomarkers; it can integrate N-glycan biomarker data with multi-source biomedical data and can foster discovery and insight within a unified data framework for glycan biomarker representation, thereby making the data FAIR (Findable, Accessible, Interoperable, Reusable) (https://www.go-fair.org/fair-principles/).
Plant characters as selection indices for plant elongation in deepwater rice

Field: Agricultural and Biological Sciences (Life Sciences)

Five deepwater rice varieties and their ten hybrids were evaluated in deepwater tanks of Bangladesh Rice Research Institute (BRRI) under raising water depth. Six characters including plant height were recorded to find out the associations among the characters as well as their contribution towards plant elongation and to identify plant characters as selection indices for plant elongation. Leaf blade length, leaf sheath length, internode length and internode number were found positively correlated with plant height. Leaf sheath length, internode length and internode number directly contributed to elongate plants. So, these characters could be used in breeding programme for plant elongation as well as effective selection.
Hierarchies of criteria in NSO board-nomination processes: insights from nomination committees’ work

Field: Social Sciences (Social Sciences)

Research question: The purpose of this paper is to create knowledge on board-selection processes and their outcomes in terms of board composition. We address two research questions: (1) What evaluative criteria are at play in board-selection processes; and (2) what hierarchies of criteria are formed when evaluative criteria are ranked? The significance of the study lies in contemporary considerations of good governance, in sport members’ (un)equal access to positions of power, and in how issues of representation relate to the legitimacy of sport governance systems and to broader societal patterns of representation, influence, and democracy. Research methods: Nomination committees are increasingly used worldwide to further good governance in sport organizations. Our analysis builds on interviews with representatives of 61 out of 71 Swedish national sport organizations’ nomination committees. Results and Findings: Our study shows that trade-offs are made not between gender and merit, as previously suggested, but between and among a wide variety of representation criteria and a wide variety of efficiency criteria. We show how tensions between criteria result in trade-offs that imply a ranking of criteria into seven types of hierarchies, only one of which prioritizes a representation-based board composition. Implications: Because rankings of multiple evaluative criteria impact any single criterion of interest (e.g. gender), future studies should take into account the range of evaluative criteria at play. For sport management and policy practitioners alike, we provide a tool to understand and address (in)adequate representation but also an imperative to consider the meaning of adequate representation.
48. Evaluation and comparison of two different crown and bridge materials (pfm and zirconia) in terms of various periodontal parameters and crestal bone levels at an interval of 6 months and 12 months

Field: Dentistry (Health Sciences)

Indirect restorations in the form of crowns and fixed partial dentures come in close proximity of the periodontal tissues. Several studies have indicated poor marginal adaptation, subgingival margin placement, and over contoured crowns can contribute to localized periodontal inflammation. However, the materials used for rehabilitation and their influence on the surrounding structures is still a question mark i.e. there is a lack of scientific information regarding how oral plaque would colonize the restoration surface. Such interaction may influence the success or clinical failure of tissue integration. It may be hypothesized that reconstructions with zirconia framework will lead to clinical outcomes similar to those with a metal restoration. If so, metal-ceramic reconstructions might be replaced by zirconia-ceramic reconstruction in the future. For proof of this change of material choice, clinical studies are needed which are lacking in the literature and there is a lacunae regarding comparison of zirconia-ceramic and metal ceramic reconstructions in various indications especially in the same environment.
Incentive equilibrium in bioresource sharing problem

Field: Decision Sciences (Social Sciences)

A dynamic game model of bioresource management problem is considered. The center (referee) which shares a reservoir, and the players (countries) which harvest the fish stock on their territory are the participants of this game. In this paper we investigate the new type of equilibrium—cooperative incentive equilibrium. The equilibria are constructed in the case, when the players punish each other for a deviation from the cooperative equilibrium, and in the case, when the center punishes them for a deviation. Some results of the numerical modelling are given.
Carbon Nanotube Sheets/Elastomer Bilayer Harvesting Electrode with Biaxially Generated Electrical Energy

Field: Materials Science (Physical Sciences)

Mechanical energy harvesters made from soft and flexible materials can be employed as energy sources for wearable and implantable devices. However, considering how human organs and joints expand and bend in many directions, the energy generated in response to a mechanical stimulus in only one direction limits the applicability of mechanical energy harvesters. Here, we report carbon nanotube (CNT) sheets/an elastomer bilayer harvesting electrode (CBHE) that converts two-axis mechanical stimulation into electrical energy. The novel microwinkled structure of the CBHE successfully demonstrates an electrochemical double-layer (EDL) capacitance change from biaxial mechanical stimulation, thereby generating electrical power (0.11 W kg−1). Additionally, the low modulus (0.16 MPa) and high deformability due to the elastomeric substrate suggest that the CBHE can be applied to the human body.
Rapid spectrophotometric determination of uranium(VI) in sea water.

Field: Chemistry (Physical Sciences)

A rapid preconcentration method for uranium(VI) in seawater based on the extraction-back extraction with capriquat (trioctylmethylammonium chloride) system is described. Uranium(VI) is extracted as the thiocyanate from 400 cm3 of a seawater sample into 30 cm3 of 2 × 10-2 mol dm-3 capriquat in benzene and back-extracted into 3 cm3 of 5.5 mol dm-3 perchloric acid containing Arsenazo III. By using this method, uranium(VI) in seawater with levels below ppb range could be determined by spectrophotometry. Other cations in seawater are found not to cause interferences. A relative standard deviation of 2.4% can be achieved.
Ethnomedicinal uses and bioactive compositions of different species of palm fruits in Karu local government area of Nasarawa State, Nigeria

Field: Agricultural and Biological Sciences (Life Sciences)

Palms belong to Arecaceae family and are the most acknowledged and extensively dispersed variety of productive tree throughout the globe that has given a large scale range for edibles and remedies to Homo sapiens. The aim of the groundwork was to record the several multifariousness of palms used as culinary and drugs in Karu, Nigeria and to find out the empirical authentication for the abundant plant-derived constituents that could explicate its native values as professed by the people in the vicinity. Individuals that are perceived by the people of Karu to have enormous proficiency and mastery in herbal practices were contacted by oral korero on the various categories of palms used for the control of vast group of ailments and the inputs assembled were recorded for further justification. Outcome of the discovery indicated that, distinct heterogeneity of palms used by the people includes: Oil palm tree, coconut palm tree, African fan palm tree, African fan palm shrub and date palm tree. These palms were used as therapy for a wide range of diseases and ailments such as: Poisoning, blurred vision, skin problems, heart diseases, high blood pressure, weakness, dehydration, brain dysfunctions, constipations, hemorrhage, mouth sores, inflammation, infertility, tumors, asthma and infections. The variations of palms used were picked out and documented by their respective scientific names, English names, and vernacular names.
Malaria, glucose-6-phosphate dehydrogenase deficiency, and Hb S.

Field: Medicine (Health Sciences)

ContraceptivesSIR,-At a time when the Dunlop Committte on Safety of Drugs has just reported on the contraceptive pill and has, albeit with reservations, put a " safe " level on it, I for one am feeling more and more uneasy about prescribing it.The excellent paper by Drs.
The Prevalence of Hysteria and Conversion Symptoms

Field: Medicine (Health Sciences)

Since 1962, a series of studies have appeared in the psychiatric literature which define hysteria with increasing precision, differentiating that syndrome from the presence of conversion symptoms alone. Hysteria was described in a recognizable fashion more than a century ago by Briquet (1859). Some fifty years later, the syndrome was redescribed by Savill (1909). After a further period of nearly fifty years, Purtell, Robins and Cohen described hysteria as it occurred in a controlled series of patients (1951). Working from Purtell's clinical data, Perley and Guze introduced specific checklist criteria for the diagnosis of hysteria in 1962. These criteria defined a female population homogeneous in prognosis, a population to be distinguished from that defined by conversion symptoms alone. Conversion symptoms are seen in a variety of medical and psychiatric illnesses, and by themselves, conversion symptoms are of little prognostic value (Gatfield and Guze, 1962; Perley and Guze, 1962; Slater and Glithero, 1965).
Feeling the Beat (and Seeing It, Too): Vibrotactile, Visual, and Bimodal Rate Discrimination

Field: Psychology (Social Sciences)

Abstract Beats are among the basic units of perceptual experience. Produced by regular, intermittent stimulation, beats are most commonly associated with audition, but the experience of a beat can result from stimulation in other modalities as well. We studied the robustness of visual, vibrotactile, and bimodal signals as sources of beat perception. Subjects attempted to discriminate between pulse trains delivered at 3 Hz or at 6 Hz. To investigate signal robustness, we intentionally degraded signals on two-thirds of the trials using temporal-domain noise. On these trials, inter-pulse intervals (IPIs) were stochastic, perturbed independently from the nominal IPI by random samples from zero-mean Gaussian distributions with different variances. These perturbations produced directional changes in the IPIs, which either increased or decreased the likelihood of confusing the two pulse rates. In addition to affording an assay of signal robustness, this paradigm made it possible to gauge how subjects’ judgments were influenced by successive IPIs. Logistic regression revealed a strong primacy effect: subjects’ decisions were disproportionately influenced by a trial’s initial IPIs. Response times and parameter estimates from drift-diffusion modeling showed that information accumulates more rapidly with bimodal stimulation than with either unimodal stimulus alone. Analysis of error rates within each condition suggested consistently optimal decision making, even with increased IPI variability. Finally, beat information delivered by vibrotactile signals proved just as robust as information conveyed by visual signals, confirming vibrotactile stimulation’s potential as a communication channel.
Systematic Identification of Methyllysine-Driven Interactions for Histone and Nonhistone Targets

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

An important issue in epigenetic research is to understand how the numerous methylation marks associated with histone and certain nonhistone proteins are recognized and interpreted by the hundreds of chromatin-binding modules (CBMs) in a cell to control chromatin state, gene expression, and other cellular functions. We have assembled a peptide chip that represents known and putative lysine methylation marks on histones and p53 and probed the chip for binding to a group of CBMs to obtain a comprehensive interaction network mediated by lysine methylation. Interactions revealed by the peptide array screening were validated by in-solution binding assays. This study not only recapitulated known interactions but also uncovered new ones. A novel heterochromatin protein 1 beta (HP1β) chromodomain-binding site on histone H3, H3K23me, was discovered from the peptide array screen and subsequently verified by mass spectrometry. Data from peptide pull-down and colocalization in cells suggest that, besides the H3K9me mark, H3K23me may play a role in facilitating the recruitment of HP1β to the heterochromatin. Extending the peptide array and mass spectrometric approach presented here to more histone marks and CBMs would eventually afford a comprehensive specificity and interaction map to aid epigenetic studies.
Orthodontic Correction of Lingually Displaced Canine Teeth in a Young Dog Using Light-cured Acrylic Resin

Field: Veterinary (Health Sciences)

Lingually displaced canine teeth is a common malocclusion condition in dogs, the treatment of which has been described 1,2,3,4,5 . Several of the previously reported treatment regimens involve the use of potentially harmful (toxic and/or dangerously exothermic) substances (methylmethacrylate) or require separate anesthetic episodes to make impressions and place the appliance. In this case, a dog was treated with directly placed appliances made of non-heat generating light-cured resin. Treatment required only one anesthetic episode to place the appliances and one more to remove them.
Menachromanol from a Photosynthetic Bacterium

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Research Article| January 01 1967 Menachromanol from a Photosynthetic Bacterium R. Powls; R. Powls Search for other works by this author on: This Site PubMed Google Scholar E. R. Redfearn E. R. Redfearn Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1967) 102 (1): 3C–4C. https://doi.org/10.1042/bj1020003C Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation R. Powls, E. R. Redfearn; Menachromanol from a Photosynthetic Bacterium. Biochem J 1 January 1967; 102 (1): 3C–4C. doi: https://doi.org/10.1042/bj1020003C Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1967 The Biochemical Society1967 Article PDF first page preview Close Modal You do not currently have access to this content.
CORRELATION OF KNEE PAIN WITH ANXIETY AND DEPRESSION IN MIDDLE-AGED KNEE OSTEOARTHRITIS PATIENTS

Field: Medicine (Health Sciences)

Background: Worldwide, osteoarthritis predicted to become the fourth leading root cause of disability. The chronic pain associated with the disease consequently results in a disabling state. The prevalence of mental health problems among pre-elderly age group is approaching closer to the level reported in elderly population. Hence the study aimed to determine the relationship of knee osteoarthritis associated joint pain with mental health impairments i.e. anxiety and depression in middle aged knee osteoarthritis population. Methods: To fulfil the purpose of the prospective, observational study, a sample of hundred participants meeting the eligibility criteria were included in the study. After giving the written informed consent, the individuals were asked to autonomously report their Numeric Pain Rating Scale (NPRS) score and Hospital Anxiety and Depression Scale score to the concerned investigators. Results and Conclusion: The mean (SD) of knee pain, anxiety and depression scores were 6.86 (1.042), 14.52 (3.450) and 14.51 (3.166) respectively. The correlation between knee pain and anxiety was 0.216 whereas the correlation between knee pain and depression was -0.036. The study revealed a weak positive correlation between knee pain and anxiety and weak negative correlation between knee pain and depression. During the management of knee osteoarthritis population, special attention should be made to address anxiety issues and the treatment of disease related joint pain should always include relaxation techniques to impart an effective management of the pain.
Zinc Inhibits Expression of Androgen Receptor to Suppress Growth of Prostate Cancer Cells

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The prostate gland contains a high level of intracellular zinc, which is dramatically diminished during prostate cancer (PCa) development. Owing to the unclear role of zinc in this process, therapeutic applications using zinc are limited. This study aimed to clarify the role of zinc and its underlying mechanism in the growth of PCa. ZnCl2 suppressed the proliferation of androgen receptor (AR)-retaining PCa cells, whereas it did not affect AR-deficient PCa cells. In LNCaP and TRAMP-C2 cells, zinc downregulated the expression of AR in a dose- and time-dependent fashion. Zinc-mediated AR suppression accordingly inhibited the androgen-mediated transactivation and expression of the androgen target, prostate specific antigen (PSA). This phenomenon resulted from facilitated protein degradation, not transcriptional control. In studies using mice bearing TRAMP-C2 subcutaneous tumors, the intraperitoneal injection of zinc significantly reduced tumor size. Analyses of both xenograft tumors and normal prostates showed reduced expression of AR and increased cell death. Considering the significant loss of intracellular zinc and the dominant growth-modulating role of AR during PCa development, loss of zinc may be a critical step in the transformation of normal cells to cancer cells. This study provides the underlying mechanism by which zinc functions as a PCa suppressor, and forms the foundation for developing zinc-mediated therapeutics for PCa.