jimnoneill/paper-to-field-training huggingface dataset:
Misfolding linked mutations of SERPINA1 gene are uncommon in preeclampsia

Field: Medicine (Health Sciences)

Background: Alpha-1 antitrypsin (A1AT) is a protease inhibitor that plays an important role in regulating oxidative stress in preeclampsia (PE). Recent studies have shown that A1AT is misfolded in PE. However, the cause of A1AT misfolding is not known. Mutations in SERPINA1 gene is an established source of A1AT deficiency. PiS and PiZ are the two common misfolding-associated mutations in the SERPINA1 gene. Objective: The purpose of this study was to evaluate the frequency of PiS and PiZ mutations in the SERPINA1 gene in preeclamptic women. Materials and Methods: We carried out a cross-sectional study by including 200 preeclamptic pregnant women. PiS and PiZ mutations in the SERPINA1 gene were genotyped by using polymerase chain reaction-restriction fragment length polymorphism method. Results: PiS and PiZ mutations were absent both in homozygous and heterozygous conditions in the preeclamptic womenConclusion: PiS and PiZ mutations in the SERPINA1 gene may not be associated with A1AT misfolding in PE.
[Rendering follicle tubes permeable again after post-partum sterilization. A report on 25 cases. Should post-partum sterilization be performed or not?].

Field: Medicine (Health Sciences)

This article discusses the success of microsurgical reversal attempts after postpartum tubal sterilization and assesses the risk of later reversal requests after postpartum sterilization. 25 of 37 requests for tubal sterilization reversals received by the authors between January 1977-December 1983 followed postpartum sterilizations. The only criteria were contraindications to another pregnancy, a history of bilateral salpingectomy, and existence of a serious hypofertility factor. No minimal tubal length was required. All reversal procedures were microsurgically performed by 3 operators. The average age of patients was 26.7 years at sterilization and 32.5 years at reversal. Ages ranged from 25 to 41 at reversal. The parity of the women ranged from 2 to 9 and averaged 4.2 children. The sterilization was performed during a cesarean section in 19 cases, of which 8 were emergency procedures. The indication for the sterilization was medical in only 7 cases. 20 of the procedures were tubal ligations and resections, 1 was application of a Yoon ring, and 4 were bilateral salpingectomies. Reasons for reversal requests were change of partner in 16 of 25 cases, death of an infant in 1 case, fear of repudiation by the husband in the cases of 4 Muslim women, and change of mind by the couple in 4 cases. 6 of the 25 women were unacceptable candidates for reversal, 4 because of bilateral salpingectomy and 2 because of poor tubal state and failure of previous surgery. 17 women underwent tubotubal anastomoses and 2 had tubouterine reimplantations. The reversal operations resulted in 12 term pregnancies, 1 spontaneous abortion, and 1 extrauterine pregnancy. The delays to pregnancy ranged from 1 to 18 months and averaged 6.6 months. The intrauterine pregnancy rate was 83% for reversals within 5 years of sterilization and 61% later. Age of the woman appeared to play no role. The postpartum period does not seem to be an ideal moment for sterilization because of its association with later requests for reversal. Several factors seem to be involved in requests for reversal, including young age at sterilization, the unpredictability of death in small children, and haste in making the initial sterilization decision. The policy of automatically recommending sterilization after a 3rd cesarean section should be reviewed since in many cases a successful delivery is still possible. Factors in successful reversal include the length of tube remaining, which is related to the sterilization technique employed, and the site of the sterilization, with ligations at the cornu and fimbriectomies giving poor results. The least mutilating forms of sterilization should be used in young women. Clips, rings, and ligations using absorbable thread with limited resection of the isthmus are reliable methods which have the advantage of not definitively compromising fertility. They can also be done by a simple laparoscopic procedure after the postpartum period.
Infectious complications following peripheral blood stem cell transplantation in patients with relapsed or refractory malignant lymphoma

Field: Medicine (Health Sciences)

Forty six consecutive patients (median age 45, range 19-65 yrs) with relapsed or refractory Non-Hodgkin's Lymphoma (NHL, n=33) and Hodgkin's Disease (HD, n=13) treated with autologous peripheral blood stem cell transplantation (PBSCT) have been evaluated for infectious complications following PBSCT. Patients received an average of 17.28 (range 1.64-98.13, SD 18.02) x 10^6/kg CD34+ cells, followed by filgrastim (median 10 days, range 6-50, SD 7.2) during the leukopenic (<1x10^9/L) period. Transplant related mortality was 0%. Febrile neutropenia occurred in 30 (65.2%) patients at a mean of 5 days after PBSC reinfusion (range 1-9, SD 2.1). In these patients, clinical and microbiological workup was done and empiric antibiotic treatment was started (piperacillin and tazobactam in all but 3 patients). Seven patients (23.3%) had proven bacteremias, 4 (13.3%) had other microbiologically documented infections (MDIs) and 19 (63.3%) had clinically documented infections (CDIs). Gram+ microorganisms were responsible for 54.5% of all documented infections (42.8% of bacteremias and 75% of other MDIs) and Gram- for 27.3% of all documented infections (28.6% of bacteremias and 25% of other MDIs). An anaerobic microorganism was isolated from blood cultures in one patient, and a fungus in another patient (14.3% of bacteremias, each). Empirical antimicrobial therapy was modified in 13 (43.3%) patients, including addition of vancomycin in 9 (30%) patients, a systemic antifungal agent in 5 (16.6%) or both in 3 (10%) patients. Correlations of a number of variables available at time of febrile neutropenia onset with the duration of febrile episode have also been investigated. Patients with higher CRP levels at febrile neutropenia onset and those with earlier onset of fever following PBSCT had significantly longer (p=0.05 and p=0.007, respectively) duration of febrile episodes. Other variables, including patients' age, gender, disease (NHL vs. HD), No. of previous lines of therapy, previous treatment with rituximab, No. of reinfused CD34+ cells, mean arterial pressure, pulse, ESR, hemoglobin, neutrophil, monocyte or platelet counts as well as peak temperature values at day of fever onset did not show significant correlations with duration of the febrile episode in this group of patients. We conclude that infectious episodes are serious but managable complications of PBSCT. Early empirical therapy is justified, and should be tailored according to local microbiological epidemiology.
Free trade agreements and female labour: The chilean situation

Field: Economics, Econometrics and Finance (Social Sciences)

This article analyses the relations between economic integration processes, employment and equality of opportunities between men and women. To this end, the case of Chile is considered, where simultaneous processes of internationalization of the economy, the pursuit of economic integration agreements and the growing incorporation of women into the labour force are taking place. The relation between integration agreements and the labour situation of women derives from three factors. Firstly, the new trade flows affect employment and wages, and there may be a differential effect by sex if the female labour force is concentrated in particular, sectors of production.
Venice IncognitoMasks in the Serene Republic

Field: Arts and Humanities (Social Sciences)

"The entire town is disguised" declared a French tourist of eighteenth-century Venice. And, indeed, maskers of all ranks—nobles, clergy, imposters, seducers, con men—could be found mixing at every level of Venetian society. Even a pious nun donned a mask and male attire for her liaison with the libertine Casanova. This book offers a spirited analysis of masking in this carnival-loving city. It draws on a wealth of material to explore the world view of maskers, both during and outside of carnival, and reconstructs their logic: covering the face in public was a uniquely Venetian response to one of the most rigid class hierarchies in European history. This vivid account goes beyond common views that masking was about forgetting the past and minding the muse of pleasure to offer fresh insight into the historical construction of identity.
Efek Terapi Musik dalam Menurunkan Kecemasan Pasien Selama Pemeriksaan MRI

Field: Health Professions (Health Sciences)

Background: Anxiety is a normal response in the face of stress which is characterized by feelings of fear accompanied by somatic signs. The patient's anxiety in the MRI examination arises because he knows he will receive medical treatment related to the use of radiation that will cause adverse effects that cause infertility or cancer. The purpose of this study was to determine the effect of music therapy in reducing anxiety when undergoing an MRI examination. Method: The design of this study used a posttest only intervention group design. The study was conducted on 18 July – 12 August 2022 in the MRI Room of the Bali Mandara Hospital, Bali Province. The sample was 72 people who were divided into 2 intervention and control groups. The inclusion criteria of this study were patients with head first examination position, age above 18 years. Exclusion criteria were patients with decreased consciousness, hearing loss and weight above 150 kg. The research instrument used the MRI-AQ questionnaire, and the Mann Whitney statistical test. Result: The results showed that most of the respondents were 46-55 years old (33.3%), most of the MRI examinations were Lumbo sacral type (54.2%), and the level of anxiety was mostly mild (91.6%). The results of the normality test of data <0.05 so that the data is not normally distributed. The Mann Whitney test was conducted to determine the effect of music therapy and obtained p = 0.001 indicating there was a significant difference between the intervention group and the control group. Conslusion: The intervention of providing music therapy to patients undergoing MRI examination has an effect in reducing patient anxiety, especially in patients undergoing MRI examination. Music makes the examination more pleasant for the patient. Music causes positive changes in the environment and distracts from the examination, relaxing the patient.
The modern mahala: making and living in Romania’s postsocialist slum

Field: Social Sciences (Social Sciences)

Almost 30 years have passed since state-socialism came to an end and several scholars sought to establish how the Romanian housing market has unfolded within a changing economic context and a strongly altered welfare system. This paper considers the most disadvantaged postsocialist groups in Romanian society and aims to advance our understanding of the housing situation in newly concentrated poor urban spaces. In developing such analysis, this article draws on local insights from Ferentari, a neighborhood in Bucharest where most residents I spoke saw a gradual degradation of their dwelling and living environment and do not expect any improvement soon. Not surprisingly, a strong indifference towards present-day politics and a potentially better and more inclusive space has colonized most minds. By studying their housing conditions and socioeconomic situation this article aims to illuminate the sudden emergence and diverse character of Romania’s underprivileged neighborhoods: the modern mahalas.
An Anthropometric and Three-Dimensional Computed Tomographic Evaluation of Two-Point Fixation of Zygomatic Complex Fractures

Field: Dentistry (Health Sciences)

Background Maintaining stability and restoring the aesthetic appearance are the fundamental goals when managing zygomatic fractures. We aimed to evaluate the stability and anthropometric outcomes of zygomatic fracture patients who underwent two-point fixation involving the infraorbital rim and zygomaticomaxillary buttress via the transconjunctival and gingivobuccal approaches without any skin incisions. Methods We examined 15 zygomatic fracture patients who underwent two-point fixation during a 3-year period. Stability was evaluated using three-dimensional facial bone computed tomography. Superoinferior and anteroposterior displacement of the zygoma was quantified. The aesthetic appearance of the periorbital region was evaluated using indirect anthropometry with standardized clinical photographs. The ratios between the eye fissure height and width, and lower iris coverage ratio were used to evaluate aesthetical changes. The bony displacement and aesthetic ratios were analyzed using Wilcoxon or Friedman tests. The correlation between the preoperative zygoma position and anthropometric values was analyzed. Results The positions of the zygoma were similar to those on the contralateral side at the long-term follow-up. The preoperative anthropometric measurements on the fractured side differed from those on the contralateral side, although these values were close to the normal values at the long-term follow-up. Furthermore, we noted that the anteroposterior displacement strongly positively correlated with the lower iris coverage rate (Spearman's coefficient= 0.678, P=0.005). Conclusions Two-point fixation of zygomatic fractures achieved stable outcomes on long-term follow-up, and also appeared to be reliable in restoring the aesthetic appearance of the periorbital region.
The effects of topically applied sucrose on the healing process of open wounds in rats - Histological examination of polysaccharides in the healing process.

Field: Medicine (Health Sciences)

ラットの背部皮膚にトレパンによる欠損創を作製し, その治癒過程に対する70%sucrose水溶液塗布の影響を6日間にわたつて観察した。治癒の指標として表皮のグリコーゲン量および真皮のヒアルロン酸量の各々の変動を組織学的に観察した。対照群には精製水を塗布した。その結果, 対照群, sucrose塗布群のいずれにおいても, グリコーゲン量は欠損創作製4日後に最大となり, sucrose塗布群でより高値となる傾向があつた。また再生表皮の分裂期表皮細胞数の増加とグリコーゲン量の増加はよく相関した。一方, ヒアルロン酸量は, 対照群で欠損創作製1日後から増加し4日後からは低下し始め6日後には1日後と同じ程度に低下した。Sucrose塗布群のヒアルロン酸量は対照群に比べ2日後, 3日後に高い傾向にあり6日後には低くなる傾向にあつた。これらの成績はsucroseが創傷治癒促進効果を発揮し得る可能性を示したものと考えられる。
Deep learning methods for financial time series classification

Field: Computer Science (Physical Sciences)

With the rapid development in Artificial Intelligence and the rise in financial literacy among people, many are trying to use artificial intelligence as a means to predict the trend of the stock market to increase their wealth more consistently. However, due to the volatility of the stock market, predicting the trend of the stock market remains a daunting task. Therefore, in this paper, we are going to dwell deeper into Artificial Intelligence, specifically into Deep Learning, and use various Deep Learning Models to predict the trend of the stock market as well as discussing the accuracy of the different models. We will be focusing mainly on various Deep Learning models such as Feed Forward Neural Network (FNN), Recurrent Neural Network (RNN), Long Short-Term Memory (LSTM), Gated Recurrent Units (GRUs), Convolutional Neural Network (CNN), Temporal Convolutional Network (TCNs) and Ensembled Deep Random Vector Functional Link (ed-RVFL). In addition, to explore the effects of ensemble learners, we decided to create an ensemble of LSTM, GRU, and TCN. This project aims to use Deep Learning models for Financial Times Series Classification. Based on the experiment with 10 stocks, we found TCN, ed-RVFL, and LSTM-GRU-TCN Ensemble produced better results as compared to the rest of the remaining models.
A Similarity-Based Approach to Aggregation

Field: Mathematics (Physical Sciences)

This paper gives an approach to the aggregation of a pair of values a and b in [0,1] assuming that there is an indistinguishability operator or similarity defined in this interval. The basic idea is to understand the aggregation of two numbers a and b as a value lambda that has the same similarity with respect to a than to b or more precisely, the degrees of equivalence of lambda with a and with b must coincide. Some interesting aggregation operators are obtained from natural indistinguishability operators associated to t-norms which are ordinal sums
Does hydrology constrain the structure of fish assemblages in French streams? Local scale analysis

Field: Environmental Science (Physical Sciences)

With the increasing alteration of flow regimes worldwide, it has become a key challenge to estimate the general linkages between species and flow patterns. In fish, the young-of-the-year (YOY) cohort size is of fundamental importance to population dynamics, and can provide valuable insights into part of the ecological functioning of river systems. Here, using 65 French sites, each with at least 4 annual samples, I investigated the influence of the seasonal inter-annual flow variability on the YOY fish assemblage within sites. Assemblage structure was described by relative abundances of species, diversity measurements (richness and Shannon's index) and species traits. Flow statistics were derived so as to reflect average conditions, low and high flow conditions, floods and overall variability, and were computed for each biological season (reproduction, growth and overwinter periods). Relationships were explored and tested by within-site co-inertia analysis, and quantified by ANCOVA models. The flow levels during the reproduction and growth periods consistently explained differences among years in 4 species guilds, although average relationships were weak (i.e. max. ∼9%). Assemblage diversity slightly declined with increasing water level during the growth period. Species responses depended on their biological and functional abilities to ensure their reproductive success under adverse hydrological conditions (e. g. time of spawning, fecundity, protection of offspring), and clearly reflected two contrasting reproductive strategies. These results are in general agreement with 'habitat template'-based theories. They suggest that flow may be locally managed to sustain or restore taxonomic or functional assemblage features, keeping in mind that the strength of the expected effect is site-specific.
Situation awareness and workload with the use of conflict resolution aid and vertical display

Field: Engineering (Physical Sciences)

Air Traffic Control (ATC) is a crucial service that ensures the safety and efficiency of aircraft flying from point to point in controlled airspace. It is thus vital that the right level and type of automation are integrated in all ATC providers to improve the Situation Awareness (SA) and reduce the workload of Air Traffic Controllers (ATCOs). Although existing studies have shown that reliable and interactive Conflict Resolution Aid (CRA) are beneficial in increasing SA of ATCOs and reducing workload levels in some cases, more empirical work needs to be done to examine the effects of different levels of reliability. In some studies, reliable and interactive CRA were found to reduce the workload of ATCOs while ensuring that they are kept in-the-loop through engaging them in strategy selection to resolve conflicts. In addition, the vertical profile display aid, designed to allow ATCOs to visualise the vertical trends of aircraft, will also be incorporated in this study. Hence this project aims to assess how SA and workload of ATCOs would be affected under two independent variables namely a “within-participant” variable which consists of the three different levels of reliability of the CRA and a “between-participant” variable which is the presence or absence of the vertical display aid. The participants were divided into 2 separate groups of 12. The first group would undergo the simulation with the vertical display aid while the second group would conduct the experiment without the vertical display aid. Each participant would be required to complete 3 different scenarios corresponding to reliable, unreliable and manual CRA. The results from this study revealed a higher SA as can be seen from a higher percentage of correct response recorded and a lower workload level from a lower percentage of timeout recorded under a reliable CRA with the presence of the vertical display aid. However, the presence of the vertical display aid was found to increase the question response latency under all 3 CRA conditions.
Coronavirus infection and ophthalmology

Field: Medicine (Health Sciences)

This article presents a review of the ocular manifestations of coronavirus disease 2019 (COVID-19) by using materials of Russian and international researchers. After the outbreak of COVID-19 began in China in December 2019, isolated works on ocular manifestations of coronavirus infection began to appear in the literature. The review article summarizes data on the origin and species of viruses that infect humans, the structure of coronaviruses, and intermediate hosts of the virus. A separate chapter is devoted to the mode of transmission for infectious. Itis shown that the main route of COVID-19 transmission from person to person is airborne. Of great interest to the ophthalmologists is the review of works devoted to the virus detection in the conjunctival sac. In particular, some studies have shown that in patients with COVID-19, the virus is present in the lacrimal fluid. According to the authors, it indicates that coronavirus might be transmitted through the conjunctiva. These statements are confirmed by clinical and experimental researches. The presence of coronavirus in tears indicates the possibility to cause disease by the ocular route. That is a potential infection source for different types of physicians during routine examinations of patients, and especially by ophthalmologists. Therefore healthcare workers should wear eye protection when dealing with patients who may have COVID-19. Ophthalmologists must take necessary safety precautions, even in conducting a routine physical examination. It is also worth noting that conjunctivitis can be the first symptom of COVID-19. It is proved that the virus in the conjunctiva was detected even in patients without symptoms of eye inflammation. Also interesting for researchers is the manifestations of coronavirus infection in animals, which, according to the authors, is essential for understanding the possible mechanisms of disease development and manifestations in humans.
The microbiologic monitoring and the effect of wiping the chart to be taken into operating room

Field: Health Professions (Health Sciences)

Objective: To evaluate the effect of wiping the chart before taking into operating room with different sterilization . Methods: a prospective comparison study was used to 90 chart which were taken into operating room with patients for culture, then they were randomly divided into 3 groups, and wiped with 0.5% ShiKang (A), 0. 5% JieXiao Jin(B) and 0.5% Peracetic Acid(C), respectively. And then, the samples for culture were taken again, After culture, calculating die cfu and positive ratio of each group before and after wiping. Results:Before wiping with disinfectant, the cfu counts(cfu/cm2) of chart surface were hard to meet the standard of operating room( I or II environment); After wiped, each group's cfu decreased, but only C group's had a significant difference, and on the positive ratio of germs culture, only B and C had significant difference too. Conclusion: After wiping with 0.5% Peracetic Acid, the chart comes from word (grade III environment) can be taken into operating room safely