jimnoneill/paper-to-field-training huggingface dataset:
Abstract PD09-05: Impact of Body Mass Index (BMI) on the Efficacy of Endocrine Therapy in Postmenopausal Breast Cancer Patients — An Analysis of the ABCSG 6 and 6a Trial

Field: Medicine (Health Sciences)

Abstract Background: Recently, we have demonstrated that BMI significantly impacts on the efficacy of anastrozole but not tamoxifen (TAM) in premenopausal breast cancer patients. As aromatase inhibitors (AIs) are a mainstay in the treatment of endocrine responsive postmenopausal breast cancer patients, it is of certain interest, if this influence of BMI on endocrine therapy is also true for the postmenopausal situation. Methods: For analysis of the ABCSG 6 and 6a trial, patients were classified as normal weight (BMI 18.5-24.9 kg/m2) or as overweight (BMI ≥25kg/m) according to WHO criteria. The underweight population was excluded from the analyses. We retrospectively analysed the ABCSG 6 trial, which examined the efficacy of TAM versus TAM + aminoglutethimide (first generation AI) in endocrine responsive postmenopausal breast cancer patients. All patients have been censored after 60 months since the majority of patients without events have been re-randomized into trial ABCSG 6a after 5 years. Further, we retrospectively analysed the ABCSG 6a trial, which examined 3 additional years of anastrozole versus no further treatment after 5 years of endocrine treatment. Results: 1,566 patients (311 events/214 deaths) and 477 patients (108 events/64 deaths) were included in the analyses of the ABCSG-6 trial and the ABCSG-6a trial, respectively. About two thirds of all patients in both trials were overweight and one third was normal weight. Analysing the ABCSG 6 trial, no difference in disease free survival (DFS) and overall survival (OS) between normal weight and overweight patients treated with TAM versus TAM + aminoglutethimide could be observed. Analysing the ABCSG-6a trial, normal weight patients treated with anastrozole showed a remarkable and significant reduced risk in DFS and OS compared to control (HR 0.464, 95%CI 0.242 0.842 p=0.02 and HR 0.372, 95%CI 0.16 0.863, p=0.02). In contrast, in overweight patients anastrozole compared to control did not improve DFS and OS (HR 0.991, 95%CI 0.611 1.608, p=0.97 and HR 0.871, 95%CI 0.456 1.662, p=0.67). Conclusion: BMI impacts on the efficacy of anastrozole but not tamoxifen in postmenopausal breast cancer patients. It seems that overweight patients in contrast to normal weight patients do not benefit from additional 3 years of anastrozole after 5 years of endocrine therapy. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr PD09-05.
Spaces of Global Production

Field: Social Sciences (Social Sciences)

Spaces of global production comprise a diverse set of spatial figures that result from and support a global division of labour. The proliferation of spatial figures in scholarly work on global production in economic geography and beyond maps a conceptual landscape. The network , the agglomeration , the frontier, the plantation, the gateway , the corridor , the zone , the enclave , and the archipelago are key concepts mobilized by social sciences and humanities scholars in order to map, problematize, analyze, and help transform the varied spaces of global production.
Evaluation of quality indicators of potatoes of different ripeness groups in the forest-steppe of the Ob region

Field: Agricultural and Biological Sciences (Life Sciences)

The results of the study of promising potato varieties in Novosibirsk region (2016-2018) are presented. The objects of the study were 14 samples of potatoes, 10 of them were modern domestic varieties not zoned in the West Siberian region. An assessment of the quality indicators of potato varieties was carried out in comparison with the following zoned varieties: Red Scarlett, Nevsky and Tuleevsky. To obtain an early harvest (75 days after planting), the varieties Lomonosovsky (36 t/ha) and Reggi (39 t/ha) were recommended for the early ripening group. In the group of mid-early varieties, the variety Samba (35 t/ha) was noted; in the mid-season group, the varieties Fritella and Vympel were distinguished (early yield 32 t/ha). High productivity during harvesting in the early ripening group was noted in the varieties Lomonosovsky (42 t/ha) and Reggi (44 t/ha). The Samba variety (44 t/ha) stood out in the mid-early ripeness group. In the mid-season ripening group, the recommended variety is Gusar (46 t/ha), which exceeded the Tuleevsky standard by 4 t/ ha. Among the varieties of the early group of ripeness, high starch content was noted in the varieties Lomonosovsky (16.3%) and Reggae (17.4%). In the mid-early and mid-season groups, one variety was distinguished in each, Samba (14.4%) and Fritella (17.0%). In the early ripening group, the dry matter content of all varieties was higher than that of the Red Scarlett standard, in the mid-early group the highest indicator was observed in the Samba variety (22.9%). In the group of mid-season varieties, the samples Vympel (25.4%) and Fritella (25.8%) exceeded the standard. High field resistance to late blight (9 points) in the epiphytotic year (2017) was revealed in the varieties Gala, Nevsky, Gusar and Fritella.
Mastectomy Incision Design to Optimize Aesthetic Outcomes in Breast Reconstruction

Field: Medicine (Health Sciences)

Background: Choosing the optimal mastectomy incision must account for oncologic, reconstructive, and aesthetic considerations, including nipple preservation, mastectomy skin margins and potential for skin involvement, mastectomy skin perfusion and viability, mastectomy skin excess, previous breast scars, the reconstructive plan, and inconspicuous new scar placement. In the present study, we aimed to assess breast reconstruction aesthetics, as they are influenced by mastectomy incision design. Methods: Nine commonly utilized mastectomy incision patterns were grouped into 3 categories: hidden scar, vertical scar, and transverse scar. Twenty plastic surgeons were asked to blindly grade before and after photographs of reconstructed breasts with regard to scar visibility and position and according to their influence on breast aesthetics. Results: Statistically significant differences were observed between the study groups. Mastectomies and reconstructions performed through hidden incisions yield the most aesthetic results. Vertical scars are favorable to transverse scars. In the case of bilateral reconstructions, symmetric scar placement is paramount to optimizing aesthetic outcomes. Conclusions: The mastectomy incision pattern significantly affects the aesthetic outcomes in breast reconstruction. Patterns borrowed from cosmetic breast surgery consistently yield highly aesthetic outcomes. Surgeons must consider oncologic factors and patient characteristics in choosing an ideal incision for each patient.
Kinetic Therapy Improves Oxygenation in Critically Ill Pediatric Patients

Field: Health Professions (Health Sciences)

Schultz, Theresa Ryan BA, RRT, RN; Lin, Richard MD; Francis, Barbara A. AS, RRT; Hales, Roberta L. BS, RRT, RN; Colborn, Shawn AS, RRT; Napoli, Linda A. MBA, RRT; Helfaer, Mark A. MD Author Information
Zinc and copper metallodrugs: a 20-year perspective on therapeutic strategies and future directions

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

This review explores the use of metallodrugs, compounds formed by coordinating metals with organic molecules, as a promising strategy to enhance therapeutic efficacy and address the limitations of conventional drugs. Essential metals, such as copper and zinc, play critical biological roles and can impart unique pharmacological properties, including improved solubility, bioactivity, and selectivity, while potentially reducing toxicity. Despite these advantages, modeling and characterizing metallodrugs remains challenging due to their variable oxidation states and diverse coordination geometries. Advanced techniques, such as NMR spectroscopy, X-ray crystallography, and mass spectrometry, are crucial for elucidating their structure and function. The future development of these drugs relies on refining these methodologies and implementing innovative delivery strategies, like metal-organic frameworks (MOFs), to create safer and more effective therapies. By strategically designing metal-ligand interactions, metallodrugs can achieve targeted bioactivity and overcome resistance mechanisms, positioning them as next-generation therapeutics with the potential to transform treatments in oncology, infectious diseases, and beyond.
Preparation and Characterization of Binary Mixture of Efavirenz and Nicotinamide

Field: Chemistry (Physical Sciences)

Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry. It publishes standard research papers in almost all thrust areas of current chemistry of academic and commercial importance. It provides a platform for rapid publication of quality research papers, reviews and chemistry letters. Oriental Journal of Chemistry is abstracted and indexed in almost all reputed National and International agencies.
Prevention of Musculoskeletal Injuries in Gastrointestinal Endoscopy – Structured Review and Perspectives

Field: Health Professions (Health Sciences)

GI endoscopy forms an important part in a daily practice of a gastroenterologist. Musculoskeletal injuries related to GI endoscopy are on the rise. Observational studies and surveys depict the importance of proper ergonomical environment when performing GI endoscopy. Our aim is to outline preventive measures in gastrointestinal (GI) endoscopy in reducing possibility for occupational injury. We review most relevant studies that outline the gravity of the problem. A detailed analysis of proposed ergonomical recommendations is performed, outlining crucial steps in injury prevention. Proper ergonomical education is a key-step in preventing occupational injury. Robotics and other mechanical solutions offer a variety of approaches tackling the ergonomical challenge. Implementing proper ergonomical education and mechanical solutions lowers the possibility if occupational injury. Strategies and appliances presented are beneficial to all GI endoscopy practitioners.
Physicochemical stability of the bevacizumab biosimilar, ABP 215, after preparation and storage in intravenous bags

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Study Objectives: To evaluate extended in-use stability of bevacizumab biosimilar, ABP 215, after dilution into intravenous bags, extended storage, and simulated infusion to enable advanced preparation and storage. Methods: Two lots of ABP 215 were diluted to high- (16.5 mg/mL) and low- (1.4 mg/mL) dose concentrations in two types of intravenous bag under ambient light conditions. Dosed intravenous bags were stored at 2°C–8°C for 35 days, followed by 30°C for 2 days, and each bag was infused on Day 37. Analysis of purity and physicochemical stability was performed using size-exclusion high-performance liquid chromatography (SE-HPLC), cation-exchange high-performance liquid chromatography (CEX-HPLC), reduced capillary electrophoresis-sodium dodecyl sulphate (rCE-SDS), subvisible particle detection assays, visual inspection, and by measuring protein concentration and potency. Results: No meaningful changes were seen in ABP 215 purity when analysed by SE-HPLC, CEX-HPLC and rCE-SDS following dilution, storage and infusion of two lots, bags, and doses. Protein concentration remained consistent throughout the study for all samples and no significant loss in potency was detected. No potentially proteinaceous particles or increases in subvisible particles were observed. Discussion: This study investigated the in-use stability of ABP 215 following dilution, extended storage, and infusion, that represent worst-case handling conditions. ABP 215 exhibited consistent product quality and activity, with no significant degradation observed under the conditions tested. Conclusion: ABP 215 retains physicochemical stability after dilution over the recommended dosing concentrations, extended storage, and simulated infusion. This supports the advance preparation and storage of ABP 215 in intravenous bags for infusion.
First identified Korean family with Sotos syndrome caused by a novel intragenic mutation in NSD1.

Field: Medicine (Health Sciences)

Sotos syndrome (SS) is a congenital overgrowth syndrome. NSD1 mutations are identifiable in most SS patients. There have been a few reports of familial inheritance of SS worldwide, but no familial cases have been reported in Korea. A 6-month-old girl had tall stature and macrocephaly with mild ventricular enlargement, and showed mild delay in motor and language development. Her mother also had tall stature and a long narrow face. The baby and her mother were suspected of having familial SS. Chromosome 5q35 microdeletion was first ruled out by fluorescence in situ hybridization analysis, and direct sequencing of NSD1 revealed a novel heterozygous mutation in exon 22 (c.6356delA; p.Asp2119Valfs*31). This report describes, for the first time, a Korean family with two generations of SS resulting from a novel intragenic NSD1 mutation.
Haemophilia A and the blood transfusion service: a Scottish study.

Field: Medicine (Health Sciences)

The demand for blood products containing factor VIII for treating patients with haemophilia A in south-east Scotland was reviewed. From 1961 to 1975 the demand for fresh frozen plasma (FFP), cryoprecipitate (CP), and antihaemophilic factor (AHF) increased by seven and a half times, while total donations increased by only a third. Patients with severe haemophilia A treated at the regional haemophilia centre used about 85% of the factor VIII issued in 1971-4, most of which was used on demand. A patient with severe haemophilia A on unlimited ondemand home treatment would need about 500 units of factor VII/kg body weight/year, and a regional haemophilia centre, treating moderate and mild cases as well as severe ones, would use 15000 units/patient/year. Altogether about 50 million units of factor VIII will be needed each year in the UK. Although cryoprecipitate is much harder to store and administer than AHF, its yield from plasma may be far greater and its cost far smaller. Unless the blood transfusion services receive increased amounts of money and reappraise their functions and operation, it seems likely that they will have to rely increasingly on commercial (and costly) sources for the major plasma fractions.
[Prediction of T-cell immune reconstitution by investigating T cell receptor excision circle and T-cell receptor beta-chain variable region clonal repertoire in leukemia patients after allogeneic hematopoietic stem cell transplantation].

Field: Medicine (Health Sciences)

Investigation of the TREC and TCRBV clonal repertoire showed that the number of naive T cell is lower and the usage of TCRBV subfamilies skewed 3 - 24 months after allo-HSCT. The immune deficiency of the patients undergoing HID-BMT is more prominent and consistent with the clinical process.
Minocycline Treatment of Genital Infections Caused by Chlamydia Trachomatis (C. trachomatis)

Field: Medicine (Health Sciences)

The clinical effect of minocycline on genital infections by C. trachomatis was investigated. Fifty cases of male C. trachomatis urethritis, five cases of C. trachomatis epididymitis and five cases of C. trachomatis cervicitis were subjected to the study. Minocycline was given orally with the dose of 200 or 300mg daily for 7 to 14 days. Direct demonstration of C. trachomatis using fluorescein-conjugated anti C. trachomatis species-specific monoclonal antibody (CTFA) was performed both prior to and after the treatment with minocycline. C. trachomatis was identified in all cases during pre-treatment period, but was negative without exception in all cases after treatment regardless of dose and duration. Subjective symptoms were variable from patient to patient, might disappear after administration of antiinflammatory agent, were lacking in some patients with urethritis and in all patients with cervicitis and therefore were found to be an unreliable index for asessment of the treatment of C. trachomatis genital infections. Dizzyness were noted among the patients treated with the daily dose of 300 mg, but these side effects were not severe enough to discontinue the treatment. From above results it is concluded that minocycline is effective in the treatment of C. trachomatis genital infections.
A Pedunculated Left Ventricular Thrombus in a Women with Peripartum Cardiomyopathy: Evaluation by Three Dimensional Echocardiography

Field: Medicine (Health Sciences)

Peripartum cardiomyopathy is a cardiac condition characterized by development of heart failure during the last month of pregnancy or during the first five months of post partum period without any other identifiable cause of heart failure. The hypercoagulable state in the pregnancy along with left ventricular (LV) systolic dysfunction predisposes the patient to thromboembolic complications like intraventricular thrombi. We report a case of a 30-year-old female with peripartum cardiomyopathy along with a highly mobile mass in the LV cavity on two dimensional echocardiography. Three dimensional transthoracic echocardiography clearly showed the pedicle of the mass attached to the interventricular septum along with internal echolucent areas within the mass. Due to denial of the patient to undergo surgery, she was started on oral anticoagulation, with complete dissolution of the mass within one month.
124 Stroke volume determined flow reserve does not predict the true severity of low-flow low-gradient aortic stenosis and is not a robust marker of contractile reserve in patients undergoing low-dose dobutamine echocardiography

Field: Medicine (Health Sciences)

Background During low-dose dobutamine stress echocardiography (LDDSE) in low-flow low-gradient aortic stenosis (LFLGAS), both the aortic stenosis (AS) severity and the presence of contractile reserve (CR) are conventionally assessed based on stroke volume flow reserve (SVFR), which is defined as stroke volume [SV] increase 20%. However frequent exaggerated chronotropic response to dobutamine with shortening left ventricular time result in SV drop. On the contrary, transvalvular flow rate (FR) (SV/ejection time) and left ventricular ejection fraction (LVEF) may increase. We aimed to assess the value of FR 200 ml/s (normal FR) and LVEF change in the identification of true severe AS (TSAS) and the assessment of CR respectively. Methods Accordingly 74 consecutive patients (mean age 78 years) with LFLGAS referred for LDDSE for determination of AS severity and CR underwent retrospective assessment of SV, FR, LVEF and standard echocardiographic parameters of AS severity (Table 1). The outcome assessed was all-cause mortality censored for aortic valve intervention. Results SVFR was present in 30 (40.5%) of the 74 patients whereas FR 200 ml/s was achieved in 60 (81.1%) (p<0.001). During the median follow-up of 316.5 days 28 (37.8%) deaths occurred. Amongst all standard echocardiographic predictors of AS severity at peak stress (aortic valve mean and peak gradient, peak velocity and area [AVA]) and clinical prognostic factors, AVA was an independent predictor of death (HR=0.1, 95%CI=0.02–0.7, p=0.03), and was therefore used to define TSAS (stress AVA 1.01cm 2 ). TSAS was present in 47 (63.5%) patients of whom SVFR correctly identified 17 (36.2%) compared to 34 (72.3%) with FR 200 ml/s (p=0.001). In the 48 patients with LVEF 50%, amongst SV, FR and LVEF changes, only the latter was an independent predictor of death (HR=0.92, 95% CI=0.87–0.98, p=0.02) (Table 2). LVEF change of <5% was the best cut-off for the prediction of death (log rank p=0.004) and therefore for determination of CR (Figures 1-2). Increase in LVEF 5% had a significant impact on survival both on patients that underwent aortic valve intervention (log rank p=0.03) and those who underwent medical management (log rank p=0.01), as opposed to presence of SVFR (log rank p=0.234 and p=0.708 respectively). Conclusions During LDDSE in LFLGAS normalised FR, not SVFR, is a better determinant of TSAS, whereas assessment of LVEF change instead of SVFR determines CR. Abstract 124 Table 1 Patient echocardiographic characteristics Rest Stress p HR (bpm) 74.9±14.5 97.5±18.7 <0.001 LVEF (%) 43±15.7 53.5±18.5 <0.001 AVA (cm 2 ) 0.77±0.13 0.92±0.2 <0.001 AVMG (mmHg) 25.7±6.7 35.3±10.9 <0.001 AVVmax (cm/sec) 328.1±43.3 384.8±52.5 <0.001 SV (ml) 56.6±14.1 64.4±16 <0.001 SVi (ml/m 2 ) 32.3±8.2
Guess what: It’s the Settlements!

Field: Economics, Econometrics and Finance (Social Sciences)

Exchanges and other trading platforms are often vertically integrated to carry out trading and settlement as one operation. We show that these vertical silos can prevent the full realization of efficincy gains from horizontal consolidation of trading and settlement platforms. Independent of the gains from such consolidation, when costs of settlement are private information, a merger of vertical silos cannot be designed to always ensure efficient trading and settlement after the merger. Furthermore, we show that efficiency can nevertheless be guaranteed either by delegating the operation of settlement platforms to agents or by forcing competition across vertical silos through cross-listings.
SH1066683.09FU

Field: Agricultural and Biological Sciences (Life Sciences)

UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
Inclusive Leadership and Education Quality: Adaptation and Validation of the Questionnaire “Inclusive Leadership in Schools” (LEI-Q) to the Italian Context

Field: Social Sciences (Social Sciences)

The United Nations Sustainable Development Programme for 2030 has established the principles of sustainable action for today’s society, one of which is to achieve quality and more inclusive education. Our society has reached the stage where quality education is no longer a privilege of a few, but a fundamental right. Therefore, not achieving quality education is equivalent to not having had the opportunity to grow and develop as fully as one is entitled to in a free and just society, which needs inclusive leadership. The objective in this study is the validation of the instrument “Inclusive Leadership in Schools” for the Italian context. The methods used are content validity through expert judgement; construct validity through exploratory and confirmatory factor analysis; and reliability through Cronbach’s alpha coefficient and the split-half method. The results reveal that both the version for school administrators and teachers and the version for families have optimal levels of validity and reliability for measuring the degree of inclusive leadership in Italian schools. The results suggest that inclusive leadership effects are expected to operate most closely via their influence on developing the improvement of teaching and learning quality and promoting a favourable school climate and culture that emphasize high expectations and quality education.