jimnoneill/paper-to-field-training huggingface dataset:
Strategies to improve the functioning and quality of life of veterans with post-traumatic stress disorder and mild traumatic brain injury

Field: Medicine (Health Sciences)

Our research investigated the relationship between various aspects of quality of life in veterans with post-traumatic stress disorder (PTSD), mild traumatic brain injury (TBI) and comorbid pathology. An analysis of the effectiveness of a comprehensive intervention in terms of various spheres of functioning and quality of life of patients was also carried out. Three hundred and twenty-nine veterans were examined, including 109 with post-traumatic stress disorder, 112 with mild traumatic brain injury, and 108 with comorbidity. The Quality of Life Assessment Scale (by to O. Chaban) was used during the initial examination and after the comprehensive therapeutic intervention. Its results were analyzed using descriptive statistics and the Mann-Whitney U test. Treatment lasted 8 weeks and consisted of standard therapy according to the unified protocols for PTSD and mild TBI, psychotherapeutic intervention (a combination of psychoeducation with elements of motivational interviewing and acceptance and commitment therapy for PTSD in the form of weekly psychotherapeutic sessions 1 or 2 times a week) and 10 sessions of transcranial direct current electrical stimulation. The conclusion was made that self-assessment of the quality of life in patients of various clinical groups differs significantly, both at the beginning of the study and after the therapy. The comorbidity of PTSD and TBI leads to the lowest quality of life in general and according to most indicators compared to the PTSD and TBI alone, and as a result of the therapy, this group showed best dynamics in all the studied areas. However, changes in employment were less compared to the PTSD group, and indicators of the quality of physical condition, social activity, financial sphere, living conditions, and the integrated indicator of quality of life remained lower compared to the TBI group.
Possible role of bone turnover markers in the diagnosis of adult hypophosphatasia

Field: Medicine (Health Sciences)

Abstract Hypophosphatasia (HPP) is a rare disorder of the bone metabolism, characterized by genetically determined low alkaline phosphatase (ALP) activity. Low ALP may also be observed in some common causes of bone fragility, such as in osteoporosis treated with antiresorptive drugs. This study aimed to verify whether differences in bone turnover markers (BTMs) could help differentiate adult patients with HPP from those with osteoporosis undergoing antiresorptive treatment. In this multicenter study, we enrolled 23 adult patients with a diagnosis of HPP and compared them with 46 osteoporotic subjects previously treated with zoledronic acid or denosumab. BTMs such as CTX, N-terminal propeptide of type I procollagen (P1NP), total ALP, and bone ALP (bALP) were measured, and ratios between BTMs were also calculated. Considering that the control group included only females, in the primary analysis we compared their characteristics with that of the 16 female patients with HPP. Both individual BTMs (CTX and P1NP) and 4 BTM ratios (ALP/P1NP, bALP/P1NP, ALP/CTX, and bALP/CTX) showed satisfactory discriminatory power, outperforming ALP alone. P1NP, in particular, had an area under the curve (AUC) of 0.962 with a cut-off of 32 μg/L, while as for the BTMs ratios, the ALP/P1NP ratio had an AUC of 0.964 with a cut-off of 1.114. Similar results were confirmed when including male HPP patients, when adjusting for age and sex, and finally when performing a sensitivity analysis only in patients with ALP less than or equal to 32 U/L (ie, the median of the distribution of the entire population). In cases of low ALP and bone fragility, BTM and their ratios could help distinguish HPP patients from osteoporotic individuals treated with antiresorptive drugs, aiding in accurate diagnosis and reducing the risk of inappropriate treatment.
Comparative Histological Study on the Effect of Erythropoietin Versus Curcumin on the Sciatic Nerve Crush Injury in a Rat Model

Field: Neuroscience (Life Sciences)

Background and Aim of Work: Peripheral nerve injuries are frequently confronted in clinical practice due to several reasons such as surgery or accidental trauma. They are often associated with poor nerve regeneration and inadequate functional recovery. Therefore, this study was planned to evaluate and compare the possible effect of erythropoietin (EPO) versus curcumin on crush injury of the sciatic nerve in rat model.Material and Methods: Seventy-eight adult male albino rats were randomly allocated into 5 groups: control sham operated, sciatic nerve injury (SNI), untreated, SNI+EPO and SNI+curcumin. SNI was induced via clamping the right sciatic nerve with a sterile tissue forceps for one minute. After 24hrs, SNI+EPO group was injected intraperitoneally with EPO (5000IU/kg) daily for two weeks. SNI+curcumin group was given curcumin (40mg/kg) daily orally for two months. The compound muscle action potential (CMAP) amplitudes were recorded at the end of each experimental period. Sciatic nerve specimens were then processed for hematoxylin and eosin, osmic acid stain, toluidine blue stain and immunohistochemical staining for neurofilament (NF). Number and diameter of nerve fibers, ratio of the myelin area to the nerve fiber area as well as area percent and optical density of NF were measured and statistically analyzed.Results: Both EPO and curcumin treated groups exhibited improvement in the histological structure of the sciatic nerve as well as significant increase in CMAP. Also, morphometric measurements including; number and diameter of nerve fibers, ratio of the myelin area to the nerve fiber area as well as area percent and optical density of NF were significantly increased compared to both SNI and untreated groups. However, all measured parameters were significantly higher with EPO as compared to curcumin.Conclusion: EPO promotes structural and functional recovery and enhances regeneration of crushed sciatic nerve better than curcumin.
Effect of goat breed on the meat quality

Field: Agricultural and Biological Sciences (Life Sciences)

The quality of goat meat has recently become an important aspect in the marketing of goats in Serbia. The aim of this study was to compare some goat meat quality parameters of various races and to determine the differences between them. Goat breeds were Balkan goat and Serbian White goat, both female in the age of four years. Analysis of quality parameters: chemical composition (moisture, protein, total fat, ash,), pH value, fatty acids, amino acids, microelements content, tenderness, cooking loss and colour measurements were done. Statistically significant difference was found between the samples of two groups of goat meat (P <0.05) in relation to: live weight (kg), water (%), fat (%), protein (%), ash (%), among 11 of 15 tested fatty acids, amino acid leucin, sensory examination of fresh meat for the palpatory evaluated firmness and in the content of copper and zinc. Statistically significant differences between the groups did not existed regarding the pH value, fatty acids eicosenoic, cis-heptadecenoic, t-elaidic, t-linolelaidic and amino acids alanine, arginine, aspartic acid, cysteine, glutamic acid, glycine, histidine, isoleucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine. Also there was no statistically significant difference in instrumental testing of the meat color, sensory evaluation of surface color, visual evaluated structure, olfactory evaluated odor and iron and manganese. These results suggest that the race of animal has an impact on meat quality.
Open-label, multicenter, phase II trial of ABI-007 in previously treated and previously untreated patients with metastatic malignant melanoma

Field: Medicine (Health Sciences)

7558 Background: ABI-007 (Abraxane TM), is an albumin-bound, nanoparticle form of paclitaxel with an improved therapeutic index that may be related to biological interactions with endogenous albumin receptors (eg, gp60) and binding proteins (eg, SPARC). The albumin-binding protein SPARC (osteonectin) was overexpressed in primary and metastatic malignant melanomas but not in normal melanocytes (Ledda et al, J Invest Derm 108:210, 1997) and was a predictor of clinical outcome in thin melanomas (Massi et al, Human Path 30:339, 1999). Methods: We conducted a Phase II study of ABX administered weekly for 3 weeks q4w without premedication in chemotherapy-naive (CN) (150 mg/m2) and previously treated (PT) (100 mg/m2) patients (pts) with measurable metastatic malignant melanoma (MMM). Results: 13 CN and 36 PT pts have been enrolled; 11 CN and 13 PT pts are currently evaluable for toxicity and response. Median age was 59 (range, 32–79); median number of metastatic sites was 2 (range, 1–8); median ECOG PS was 0 (range, 0–1). 8 CN and 12 PT pts had visceral involvement. The median number of monthly cycles received was 4 (range, 2–6) for CN pts and 4 (range, 1–6) for PT pts. 9 CN and 25 PT pts are continuing treatment. 84% (CN) and 92% (PT) of cycles were given without dose modification. No treatment-related (TR) deaths or TR grade (G) 4 toxicities occurred; no cases of febrile neutropenia were reported. TR G3 toxicities included fatigue (13%); neutropenia (13%); leukopenia (8%); rash (8%); alopecia, anemia, infection, lymphedema, motor neuropathy, and tumor pain (4% each). 3 CN and 9 PT pts have progressive disease. 2 CN pts have achieved a partial response; 1 additional CN and 4 PT pts with stable disease have continued on ABX without progression for >/= 24 weeks. Conclusions: ABX was well tolerated and resulted in long-term disease control in patients with MMM, some of whom had rapidly progressive disease while on previous therapy. Final study results will be presented. However, based on these encouraging early results in pts with aggressive visceral disease, further studies with ABX in MMM are being considered. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration American BioScience American BioScience
State-space adjustment of radar rainfall and stochastic flow forecasting for use in real-time control of urban drainage systems

Field: Engineering (Physical Sciences)

Merging of radar rainfall data with rain gauge measurements is a common approach to overcome problems in deriving rain intensities from radar measurements. We extend an existing approach for adjustment of C-band radar data using state-space models and use the resulting rainfall intensities as input for forecasting outflow from two catchments in the Copenhagen area. Stochastic greybox models are applied to create the runoff forecasts, providing us with not only a point forecast but also a quantification of the forecast uncertainty. Evaluating the results, we can show that using the adjusted radar data improves runoff forecasts compared to using the original radar data and that rain gauge measurements as forecast input are also outperformed. Combining the data merging approach with short term rainfall forecasting algorithms may result in further improved runoff forecasts that can be used in real time control.
Microstructure and Wear Resistance of Martensite Wear-resistant Steel and Bainite Wear-resistant Steel

Field: Materials Science (Physical Sciences)

The microstructures and wear resistance of 400 HB grade martensite wear-resistant steel(NM400) and meta-bainite wear-resistant steel(NB400) were investigated by contrast.The results show that the microstructure of NM400 steel is tempered lath martensite,and the microstructure of NB400 steel is mainly lath bainite.On condition of sliding wear,the resistance of NM400 steel is superior to that of NB400 steel;and on condition of impact abrasive wear condition,the impact wear resistance of NM400 steel is superior to that of NB400 steel when the impact energy is lower,but the impact wear resistance of NB400 steel is superior to that of NB400 steel when the impact energy is higher.
Bronzetti votivi ellenistici dal centro Italia. Un approccio artigianale ed economico

Field: Arts and Humanities (Social Sciences)

In the central Apennine region, small votive bronzes representing especially Hercules have definitely played a major role in votive deposits since at least the Archaic Period. In this paper, the systematic study of more than 250 examples from new (Corfinium and Alba Fucens) and old excavations (Castelvecchio Subequo, Caramanico and Carsoli) is carried out, applying both an artisanal and an economic perspective. The analysis is conducted on several levels. Firstly, a more traditional approach is taken in which the context is considered. Then a typological analysis and a study of the chronology of these objects support the attempt to conduct a metrological evaluation, based on the systematic analysis of their dimensions and weights. Finally the attempt to re-establish the economic value of these objects is carried out.
Implementation Process of a Canadian Community-based Nurse Mentorship Intervention in HIV Care

Field: Health Professions (Health Sciences)

We describe salient individual and organizational factors that influenced engagement of registered nurses in a 12-month clinical mentorship intervention on HIV care in Canada. The intervention included 48 nurses and 8 people living with HIV (PLWH) who were involved in group-based and one-on-one informal mentorship informed by transformative learning theory. We evaluated the process of implementing the mentorship intervention using qualitative content analysis. The inclusion of PLWH as mentors, the opportunities for reciprocal learning, and the long-term commitment of individual nurses and partner organizations in HIV care were major strengths. Challenges included the need for multiple ethical approvals, the lack of organizational support at some clinical sites, and the time commitment required by participants. We recommend that clinical mentorship interventions in HIV care consider organizational support, adhere to the Greater Involvement of People Living with HIV/AIDS principles, and explore questions of professional obligations.
Age and tectonic setting of the Bambukoy tin-bearing volcano-plutonic assemblage (Barguzin–Vitim superterrane of the Central Asian orogenic belt)

Field: Earth and Planetary Sciences (Physical Sciences)

Geochemical, geochronological (U–Pb zircons, ID-TIMS) and isotope-geochemical (Sm–Nd) studies of the rocks of the Bambukoy volcano-plutonic association, which form the Zhanok-Bambukoy volcano-tectonic structure within the Anamakit–Muya terrane on the northern flank of the Barguzin–Vitim superterrane of the East Transbaikalian segment of the Central Asian orogenic belt. The association includes volcanic rocks of the Zhanok Suite (dacites and rhyolites mainly), as well as leucocratic and biotite granites of the Bambukoy Complex that cut through them. The granites of this complex host the Mokhovoe tin deposit, which is attributed to the tin-porphyry formation. Subvolcanic rocks of the Zhanok Suite are considered as ore-bearing. The geochemical features of the volcanic rocks of the Zhanok Suite and the granites of the Bambukoy complex bring them closer to S-type granites, and belonging to a single tin-bearing Bambukoy volcanic-plutonic association. The formation of this association is determined by the age interval 834 ± 23–818 ± 7 Ma. The isotopic data point to a source of parental magmas from the rocks of the Bambukoy volcano-plutonic association, formed as a result of mixing of the material of two crustal sources, the mature Early Precambrian and the juvenile Early Baikal. The geochemical data also point to an exclusively crustal source of the rocks of this association. Thus, the Bambukoy tin-bearing volcano-plutonic association was formed in the Neoproterozoic time (Tonian), most likely under lithospheric extension conditions due to a source with a complex and long crustal prehistory.
Arsenic trioxide combined with transarterial chemoembolization for primary liver cancer: A meta‐analysis

Field: Medicine (Health Sciences)

Abstract Background and Aim The benefit of combination therapy of arsenic trioxide (As 2 O 3 ) and transarterial chemoembolization (TACE) is debated. This meta‐analysis was conducted to determine whether As 2 O 3 &TACE therapy achieves better therapeutic effects compared with TACE alone for primary liver cancer. Methods A systematic search of both English and Chinese databases was conducted for randomized controlled trials. The main outcomes were therapeutic responses, survival rates, improvement in quality of life, and adverse events. All data analyses in this study were carried out using Review Manager software and STATA software. Results Eighteen randomized controlled trials involving 1412 participants were included. The pooled objective response rate was significantly higher in the As 2 O 3 &TACE group compared with the TACE group (relative risk [RR] 1.36, 95% confidence interval [CI] 1.16–1.58, P < 0.0001), and the pooled clinical benefit rate was also significantly higher (RR 1.18, 95% CI 1.08–1.29, P = 0.0002). A higher pooled result was obtained from the combination group for 1‐year survival rate (RR 1.37, 95% CI 1.23–1.53, P < 0.00001). As 2 O 3 &TACE therapy was not superior to TACE alone for improvement in quality of life (RR 1.15, 95% CI 0.98–1.36, P = 0.09). There was no significant difference in the risk of adverse effects. When a subgroup analysis was performed, both administration methods of As 2 O 3 (intravenous or arterial) were effective for all evaluating indicators except the improvement in quality of life. Conclusions Adjuvant As 2 O 3 therapy combined with TACE achieves better therapeutic effects compared with TACE alone. Both the intravenous administration of As 2 O 3 and the arterial administration of As 2 O 3 were good options for clinical practice.
Protection and restoration are needed to reverse damage caused by mobile fishing gear

Field: Environmental Science (Physical Sciences)

Surveys of an area once home to numerous horse mussel beds showed that damage from mobile fishing gear depleted the abundance of the species from well over 100 mussels per square meter to just four mussels per square meter in 2010. After banning all mobile fishing gear for seven years, the ecosystem had not recovered. Horse mussels act as a keystone species, so without a critical number of mussels in the habitat, other species are unable to come back. Restoration efforts are needed alongside spatial protection to fix the damage caused.
Middle Cerebral Artery Blood Velocity and Cerebral Blood Flow in Sickle Cell Disease

Field: Medicine (Health Sciences)

To understand better the relationship between blood velocity measured by transcranial Doppler and cerebral blood flow measured by the luXe inhalation method, we examined 23 patients undergoing evaluation in the Comprehensive Sickle Cell Center at Columbia University. Blood velocity in the middle cerebral artery was directly related to cerebral flow (r=0.77; p&lt; 0.05). A multivariate analysis in this sample made it possible to improve this correlation to account for more than 90 % of the variability in cerebral blood flow by the use of transcranial Doppler measures of velocity and pulsatility along with the patient&apos;s age and hematocrit (r=0.95; p&lt;0.001). It is likely that the combination of Doppler and clinical or demographic variables in other diseases will similarly improve the quantitative estimation of cerebral blood flow. (Stroke 1991^2:27-30) In 1982, the transcranial Doppler (TCD) ultra-sound device was introduced which, by using alower frequency probe, was able to record blood velocity from the basal cerebral arteries through an intact cranium.1 The TCD device is becoming accepted as a useful tool for the evaluation of intracranial stenosis, vasospasm, and the intracra-
External electric field and UV-ozone treated Ti3C2T x -MXene nanosheets and their hole injection tailoring in UV organic light-emitting diodes

Field: Materials Science (Physical Sciences)

Abstract Solution-processed 2D nanosheets of Ti 3 C 2 T x -MXene have been facilely synthesized with ultrasonic-assisted liquid phase exfoliation. X-ray diffraction, scanning electron microscope, transmission electron microscope, atomic force microscopy and x-ray photoelectron spectroscopy measurements confirm that the Ti 3 C 2 T x -MXene nanosheets have been successfully synthesized, showing good film morphology and exceptional electronic properties. The comprehensive properties of Ti 3 C 2 T x -MXene nanosheets are systematically optimized by combination with appropriate sizes of Ti 3 C 2 T x -MXene nanosheets, external electric field and ultraviolet (UV)-ozone treatment. With Ti 3 C 2 T x -MXene nanosheets as hole injection layer and PBD as emissive molecule, UV organic light-emitting diodes (OLEDs) have been configurated and shown superior performance with maximum radiance of 1.47 mW cm −2 , maximum external quantum efficiency of 1.084% and electroluminescent peak around 400 nm. The effects of external electric field and UV-ozone treatment on hole injection ability of Ti 3 C 2 T x -MXene nanosheets are investigated in details and further analyzed with impedance spectroscopy. Our experiments pave an alternative approach for advancing Ti 3 C 2 T x -MXene nanosheets and UV OLEDs.
Correction. Synthesis in the Isoquinoline Series. Selective Demethylation of 6,7- and 7,8-Dimethoxy-2,3-dihydro-4(1H)-isoquinolones.

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrection. Synthesis in the Isoquinoline Series. Selective Demethylation of 6,7- and 7,8-Dimethoxy-2,3-dihydro-4(1H)-isoquinolones.G Grethe, V Toome, H Lee, M. Uskokovic, and A BrossiCite this: J. Org. Chem. 1968, 33, 11, 4315Publication Date (Print):November 1, 1968Publication History Published online10 September 2003Published inissue 1 November 1968https://pubs.acs.org/doi/10.1021/jo01275a617https://doi.org/10.1021/jo01275a617research-articleACS PublicationsRequest reuse permissionsArticle Views43Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts