jimnoneill/paper-to-field-training huggingface dataset:
Cytological and histopathological studies on the effect of honey in experi-mentally infected wounds in Wistar rats

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Honey is used as food and home remedy in of India and other countries. Scientific studies have been carried out to support these properties of honey in this investigation, incision wounds of rats that were infected with three bacterial strains viz. Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, have been treated with honey and evaluated for its effect on days 1, 3, 6, 9 and 12 post-operatively with the help of smears and biopsies collected from lesions. Cytological and histopathological investigations of infected wounds conformed significant healing property of honey in and reduction in size.
Supplementary Figure 3 from A Randomized Placebo Controlled Phase II Trial Evaluating Exemestane with or without Enzalutamide in Patients with Hormone Receptor–Positive Breast Cancer

Field: Medicine (Health Sciences)

<p>Plasma trough concentrations by week for (A) enzalutamide and (B) exemestane The labeled values denote mean (SD). The open circles denote trough concentration values of individual patients. Solid squares and vertical lines denote mean with error bars by one SD in both directions. Abbreviations: SD, standard deviation.</p>
Promoting a Sense of Belonging in Online Learning Communities of Inquiry

Field: Social Sciences (Social Sciences)

A sense of belonging (SoB) is a valued concept in campus-based learning, being firmly linked with improved student attainment, increased learners’ satisfaction and reduced attrition rates. Some researchers even assert that learners are unable to fulfil the goals of higher education without acquiring a SoB. This article recognises that SoB can help promote and consolidate learning and seeks to specify how tutors may nurture online learners’ SoB. An adapted version of the Community Inquiry Framework (CoIF) is used to frame specific suggestions for action. This revision of the well-known Framework focuses upon the overlapping intersections of the three Presences, entitled Influences: ‘Trusting’, ‘Meaning-making’ and ‘Deepening understanding’. For each Influence, guidance illustrated by examples is offered, leading to particular suggestions that concentrate upon the promotion of a sense of belonging as an important aspect of the online tutor’s facilitative activities.
Different Active Disturbance Rejection Controllers Based on the Same Order GPI Observer

Field: Engineering (Physical Sciences)

As the higher-order or generalized extended state observer (ESO), generalized proportional-integral (GPI) observer (GPIO) have been proposed to enhance the active disturbance rejection (ADR) control (ADRC) systems disturbance rejection ability. However, different ADR controllers can be deduced based on the same order GPIO, resulting in different dynamic performances. In this paper, ten different ADR controllers based on the fourth order GPIO are present. In order to reveal the relationship between these ADR controllers and the conventional ADR controllers based on the third order ESO, six different third-order-ESO-based ADR controllers are present and compared with the fourth-order-ESO-based ADR controllers. To ease the comparison between different ADRC systems, a common expression is built for different ADR controllers. A novel frequency-domain analysis method is also introduced to reveal how the observer and feedback control law affects the closed-loop control systems dynamic performance. The effectiveness of the proposed method is verified on the test bench based on dSPACE DS1103.
557 Neoadjuvant Camrelizumab in combination with albumin paclitaxel and cisplatin for patients with locally advanced esophageal squamous cell carcinoma (ESCC)

Field: Medicine (Health Sciences)

Background

The pathologic complete response (pCR) rate occurs less than 10% of patients(pts) with neoadjuvant chemotherapy agents in locally advanced ESCC, Programmed death-1 (PD-1) blockade may induce tumor regression in pts with advanced ESCC. Camrelizumab (anti-PD-1) is standard of care as second-line therapy for advanced ESCC in China. With the potential benefit of combining Camrelizumab with neoadjuvant chemotherapy, we intended to assess the efficacy and safety of Camrelizumab combined with albumin paclitaxel and cisplatin in neoadjuvant therapy of locally advanced ESCC.

Methods

28 pts with histologically confirmed stage II-IVA ESCC were enrolled. Eligible pts were aged 18~75 years with no prior any therapy. Pts received 2~4 cycles of Camrelizumab (200mg IV q3w) plus albumin paclitaxel (260 mg/m2 IV q3w) and cisplatin (75 mg/m2 IV q3w) followed by surgery within 4~6 weeks after completion of neoadjuvant therapy. The primary endpoint was pCR, the secondary endpoints included major pathologic response (MPR), R0 resection rate, objective response rate (ORR), disease-free survival (DFS) and safety.

Results

From Jul 27 2019 to Jan 29 2021, 28 eligible pts were enrolled, neoadjuvant treatment was completed in 28 pts. 12 pts (42.9%) had clinical complete response (cCR), and the ORR was 78.6% (22/28). All pts underwent surgery and surgical treatment was not delayed. The pCR was 32.1% (9/28), MPR was 53.6% (15/28). Notably, R0 resection rate was 100% (28/28). None of 28 pts progressed, the DFS was not yet achieved. The average intraoperative blood loss was 139ml (100–300ml) and the average hospitalization time after operation was 17 days (11–35 days). No patient developed anastomotic leak and other surgical treatment-related toxicity. The grade 1–2 treatment-related AEs were reactive cutaneous capillary endothelial proliferation (RCCEP) (35.7%), hepatotoxicity (21.4%), weakness (10.7%), thyroid dysfunction (10.7%). No serious AEs resulted in termination of treatment.

Conclusions

Camrelizumab in combination with albumin paclitaxel and cisplatin followed by surgery for locally advanced ESCC showed promising downstaging effect and pCR with good tolerance, and further study is needed.
Balanced Scorecard de ANETA

Field: Business, Management and Accounting (Social Sciences)

Los autores comentan que el presente trabajo corresponde a un Balanced Scorecard que se lo aplica a la empresa ANETA realizando un analisis tanto en sus estrategias como en su ejecuion, empleando indicadores y objetivos, que midan la actuacion de la empresa desde cuatro perspectivas equilibradas; las finanzas, los clientes, los procesos internos, y el aprendizaje y crecimiento segun lo aprendido
INDUCTION OF CHILLING TOLERANCE IN GRAPEFRUIT: PHYSIOLOGICAL AND MOLECULAR ASPECTS

Field: Agricultural and Biological Sciences (Life Sciences)

Many tropical and subtropical fruits and vegetables, such as citrus, are sensitive to low chilling temperatures and, thus, must be stored after harvest at relatively high temperatures that enhance their deterioration. In previous studies, we found that a short pre-storage hot water rinsing treatment (at 62°C for 20 s) markedly increased chilling tolerance in grapefruit and reduced the development of chilling injuries following 6 weeks of cold storage at 2°C. Molecular analysis studies using PCR cDNA differential display and PCR cDNA subtraction techniques revealed that the hot water treatment increased the expression of several stress-related cDNAs in the fruit peel tissue, including heat shock proteins (HSPs), dehydrins, and a sodium proton antiport gene known to be involved in plant salt tolerance. Evaluation of gene expression patterns showed that many of these stress genes were only temporarily induced by the heat treatment alone when the fruit were kept at ambient temperatures, but markedly and continually expressed by the combination of heat followed by cold storage.
PENICILLIN OINTMENT-IMPREGNATED GAUZE IN THE LOCAL TREATMENT OF INFECTIONS

Field: Medicine (Health Sciences)

LOCAL administration of penicillin, either alone or in combination with general administration, is often advantageous in the treatment of localized infections in accessible sites. However, the commonly used means of topical application have certain disadvantages. For example, sprinkling of penicillin powder on infected surfaces does not carry the material into crevices and tracts, and as Bodenham 1 has pointed out, the drug may be too rapidly absorbed and excreted by the body; moreover, powdered sodium penicillin in undiluted form is somewhat irritating to the tissues. The instillation of penicillin solutions, though satisfactory in situations in which the instilled material is well retained, is often inefficient because the solution drains away from all but the more dependent portions of the lesion. Gauze packs soaked in penicillin solution require relatively large amounts of the drug, and there are often technical difficulties in maintaining contact with all parts of the lesion and in
Some Biological Properties of Chondrostoma regium (Heckel, 1843) Inhabiting Sir Dam Lake (Kahramanmaraş)

Field: Agricultural and Biological Sciences (Life Sciences)

In this study, the age, growth and reproduction properties of Chondrostoma regium (Heckel, 1843) in Sir Dam Lake were investigated during the period from December 1996 to July 1998. The age composition ranged from I to V and the first age group dominated in the total samples. The sex percentage of the examined samples were 54.66% for females and 45.34% for males. The age-length and age-weight in females and males were
Two Layers Trust-Based Intrusion Prevention System for Wireless Sensor Networks

Field: Computer Science (Physical Sciences)

Security of a wireless sensor network is aimed at ensuring information conﬁdentiality, authentication, integrity, availability and freshness is an important factor considering the criticality of the information being relayed. Hence, the need for an intrusion detection/prevention system. Conventional intrusion avoidance measures, such as encryption and authentication are not sufficient because they become useless in the event of a sensor node being compromised, hence, can only be seen as a first line of defence in the network after which intrusion detection schemes follow. In this paper, two layers trust-based intrusion detection scheme was developed for wireless sensor networks. A trust-based model is presented to detect intrusions to the network. Scenarios were created by using different set of weights. By injecting 2%, 5% and 10% malicious nodes from the 100 nodes considered, the results obtained were carefully observed. For scenario 2 (S2) with 2% and 5% malicious nodes injected, the model achieved the best result in all cases with an average detection accuracy of 97.8% while scenario 3 (S3) with 10% of malicious nodes introduced recorded the best performance with an average accuracy of 96%. Hence, the model will be suitable with combination of weights in S2 with small networks but when the scale of the network increases, the set of weights in S3 are best with the model.
Black Dad Shine: A Concept Mapping Approach to Identifying the Qualities of Black Father Flourishing

Field: Social Sciences (Social Sciences)

Abstract

Black men in America face systemic and structural barriers that have persisted for years. These barriers create inequities that can negatively affect their physical and mental wellbeing and their fatherhood and family experiences. Previous research on Black fathers has highlighted deficits, with minimal studies focused on solutions, particularly as conceptualized by Black men themselves. Based in health equity, the current study utilized concept mapping, a community-based participatory research method, to assess what Black men in America need to flourish in the socioecological context in which they live. Black participants (n = 9), from a pre-established community advisory board that is working on a peer intervention to address early childhood adversity and toxic stress in the Black community, brainstormed 60 unique items associated with Black father flourishing and grouped these items into 6 unique clusters. Two clusters focused on Black men seeing themselves, their purpose, and their fatherhood role in a positive light (Positive Internal Mindset; Purposeful Leadership), 2 focused on healthy relationships (Sustained Mentorship and Accountable Growth; Receptivity to Influence), 1 focused on the tools necessary to build and maintain healthy relationships (Tools of Relational Engagement), and 1 focused on equitable access to external resources (Gatekeeper-less Resources). Participants ranked “a sense of purpose” and “positive self-image" as most important to Black father flourishing and “mentorship” and “encouragement” as the most feasible to address through a peer intervention. By centering the voices of Black men and those who support them, this study highlights stakeholder priorities about best practices for Black fatherhood.
Cultivation of Trypanosoma cruzi in irradiated muscle cells: improved synchronization and enhanced trypomastigote production

Field: Immunology and Microbiology (Life Sciences)

SUMMARY Since the in vitro production of trypomastigote stages of Trypanosoma cruzi in cell culture is frequently limited by (1) host cell overgrowth and (2) by the unequal redistribution of parasites after cell division resulting in asynchronous release of trypomastigotes, a culture system was devised in which host cell mitosis was inhibited by irradiation prior to parasite infection. L-6 rat myoblast cells when exposed to 3000 rad. of gamma radiation lost their ability to divide but remained susceptible to infection with, and capable of supporting the intracellular growth of, T. cruzi . Using this approach it proved possible to have virtually 100% of cells infected and achieve much better synchronization of trypomastigote release than with conventional culture systems. Additionally, the total number of parasites provided approached 1 × 10 9 trypomastigotes/ 150 cm 2 flask, a significant increase over other culture systems. Preliminary studies with Plasmodium fallax and Eimeria tenella indicate that irradiated host cells may be utilized to advantage for the cultivation of other intracellular protozoa.
Fundamental Solutions of Dynamic Poroelasticity and Generalized Termoelasticity

Field: Mathematics (Physical Sciences)

Fundamental solutions of dynamic poroelasticity and generalized thermoelasticity are derived in the Laplace transform domain. For poroelasticity, these solutions define the solid displacement field and the fluid pressure in fluid-saturated media due to a point force in the solid and an injection of fluid in the pores. In addition, approximate fundamental solutions for short times are derived by analytically inverting the Laplace transform expressions. Finally numerical results are presented to highlight the essential features of the problem as well as to investigate the accuracy of the time domain solutions.
The charter of older people rights to participate in clinical trials

Field: Health Professions (Health Sciences)

The results of initial literature review indicate thai elderly persons are underrepresented in the clinical trials on which clinical recommendations are based. This gave stimulus to perform the 'lncreasing the PaRticipation of the EIDerly In Clinical Trials' (PREDICD project, financed by the EU within the FP7. The goal of the PREDICT was to study reasons why older people are excluded from clinical trials based on age-related criteria and development of the charter including recommendations to prevent their exclusion. The project gathered investigators from 11 inslitutions in 9 countries: Czech Republic, lsrael, ltaly, Lithuania, the Netherlands, Poland, Romania, Spain, and the UK. Within the scope of PREDICT, first, to assess the scope of the problem the systematic review of literature was performed, !hen the opinion shared by the health care professionals, ethicists, and representatives of pharmaceutical industry on the possible reasons of underrepresentation of ald people in trials was examined, !hen finally the opinion of elderly patients and their caregivers were assessed. The analysis of gathered data enabled creation of PREDICT charter which contains recommendations aiming to increase the participation of elderly people in clinical trials.
Two-Switch Dual-Buck Grid-Connected Inverter with SPWM Control and Single Current Sensor

Field: Engineering (Physical Sciences)

This paper presents a two-switch dual-buck grid-connected inverter with sinusoidal pulse-width modulation (SPWM) control and single current sensor. The freewheeling current flows through the independent diodes instead of the body diodes of the switches, so reverse recovery losses of the diodes can be reduced. Half of the power devices operate in high frequency at each half line cycle, and the others switch at grid period and can realize zero-current switching (ZCS), thus the efficiency can be increased. Moreover, uniploar modulation is adopted. Therefore, weight and volume of the output filter can be decreased. SPWM control is adopted, so the output filter is easy to design. Only one current sensor is used. The operating principle is illustrated. Finally, simulation results verify the theoretical analysis and satisfy the IEEE Std. 929-2000.
Trends and operators of instrumental vaginal deliveries in Jos, Nigeria: A 7-year study (1997–2003)

Field: Medicine (Health Sciences)

Context: Instrumental vaginal delivery is one of the lifesaving functions of emergency obstetric care to reduce perinatal and maternal morbidity and mortality.Objective: To determine the instrumental vaginal delivery rate, the trends, and the status of their operators in Jos University Teaching Hospital, Nigeria (JUTH) over a 7-year period (1997–2003).Study Design: A 7-year cross-sectional study of obstetric service data from 1st January 1997 to 31st December 2003.Patients and Methods: A register was kept for all cases of instrumental deliveries at JUTH from 1st January 1997 to 31st December 2003. This register with the patient case notes and neonatal ward records was used to conduct this study.Results: During the study period, there were a total of 17,888 deliveries and 349 instrumental vaginal deliveries, giving a rate of 1.95%. Out of these, 238 (68.2%) were vacuum extraction and 111 (31.8%) were forceps delivery. There was a 67% decline in the use of these instruments from 84 (3.18%) in 1997 to 34 (1.05%) in 2003. Majority 313 (90%) of the procedures were performed by residents (Registrars 49%, Senior Registrars 41%). Consultants performed 10%, and all were in the first four years of the study. Forceps delivery rate 0.62% and vacuum delivery rate was 1.33%. There was a strong negative correlation with the performance of IVD in JUTH. At the current trend, no forceps delivery (R = −0.93008) will be performed in JUTH in 2005 while only 4 vacuum deliveries (R = −0.80015) will be conducted in in the same period.Discussion: There is a low instrumental vaginal delivery rate in JUTH with a strong negative correlation in the performance of these procedures. Most procedures are performed by residents, and vacuum is the preferred procedure.Conclusions: Instrumental vaginal delivery in JUTH is a dying art. Training and re-training of resident doctors on this lifesaving function is recommended.
Toward complete area coverage of a reconfigurable tiling robot by following obstacle shape

Field: Computer Science (Physical Sciences)

Abstract Complete area coverage is a crucial factor for a floor cleaning robot. Self-reconfigurable tiling robots have been introduced over robots with a fixed shape for floor cleaning since they improve the area coverage by the flexibility of shape-shifting in cluttered environments. The existing coverage methods of reconfigurable tiling robots follow the tiling theory to cope with the area coverage problem. However, these methods merely consider a limited set of predefined shapes for the reconfiguration of a robot. The consideration of a limited set of predefined shapes for the reconfiguration impedes the ability of coverage to a certain extent in typical floor environments. Therefore, this paper proposes a novel method to improve area coverage of a tiling robot by reconfiguring according to the shape of obstacles. To this end, the required hinge angles for reconfiguring per the shape of an obstacle are determined by a genetic algorithm. The proposed method considers an optimized shape for reconfiguration in lieu of a limited set of predefined shapes. The coverage improvement of the proposed concept has been compared against the existing coverage methods of tiling robots to validate the performance. According to the experimental results, the proposed method surpasses the existing coverage methods of tiling robots from the perspective of area coverage, and the improvement is significant and noteworthy.
Effects of cortisone on lipid and cholesterol metabolism in the rabbit and rat

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Cortisone, 5 mg/day, first increased the plasma triglyceride levels of 2.5-kg male rabbits fed stock, high-fat, fat-free, or semistarvation diets. Later, hypercholesteremia was observed only in those plasmas in which triglyceride levels exceeded 400 mg/ml. Cortisone diminished accumulation of stainable fat in livers of animals fed fat, and of carbon particles in Kupffer cells; it caused parenchymal cells to enlarge and show vacuolization, abnormal nuclei, and fragmented cell walls. Rate of loss from plasma of parenterally administered triglyceride was similar in cortisone-treated and hepatectomized rabbits. Cortisone did not alter: lipid absorption, liver cholesterol, incorporation of acetate into cholesterol, bile cholesterol, rate of exit of cholesterol from plasma, Triton-induced hyperlipemia, or lipoprotein-lipase. Concentration of liver glycogen did not correlate with cortisone-induced lipemia. The authors suggest that cortisone induces hypercholesteremia only indirectly as a result of a sufficient degree of preceding hypertriglyceridemia, which stems in part from a relative inability of the liver to remove triglyceride from plasma.
Comparison of Seed Morphology and Seed Coat Chemistry in Ophrys (Orchidaceae) Species

Field: Agricultural and Biological Sciences (Life Sciences)

Orchidaceae is the largest flowering plant family in the world and holds significant importance in terms of biological diversity. Many of the species are found in endemic regions, serving as important indicators for the conservation of biological diversity. Therefore, research on the morphology, seed and embryo structures, chemical composition, and taxonomy of orchids is crucial for species conservation, habitat restoration, and the sustainability of natural habitats. This research involves comparing the morphometric and chemical contents of seeds belonging to certain Ophrys L. species and examining interspecies relationships. The micromorphological features of the seeds were analyzed by using light microscopy and scanning electron microscopy (SEM), while their chemical contents were compared by using Fourier transform infrared spectroscopy (FT-IR) analysis. Seed and embryo morphology, morphometric analysis, and seed coat chemistry hold diagnostic significance. In species of the Ophrys genus, features like anticlinal wall structure and periclinal wall reticulation are considered weak taxonomic characters. FT-IR analysis identifies specific chemical groups in orchid samples, revealing significant differences in absorbance values and chemical compositions among the different orchid species. Particularly, Ophrys lycia (Lycian Kaş Orchid) shows distinct separation from closely related species at peak points such as 2917 and 2850, 1743, 1515, 1240, and 1031 cm-1. Common peak points in the fingerprint region (1200- 700 cm-1) indicate similarity between O. apifera and O. reinholdii subsp. reinholdii. O. ferrum-equinum, O. mammosa subsp. mammosa, O. fusca subsp. leucadica, O. reinholdii subsp. reinholdii, and O. iricolor exhibit similar absorbance values in the range of 1500-1000 cm-1. These results provide valuable preliminary information about the structure of orchid seed coats, reticulation presence and pattern, chemical profiles, distribution, and dormancy-germination processes.