jimnoneill/paper-to-field-training huggingface dataset:
Childhood prevention of coronary heart disease

Field: Medicine (Health Sciences)

Journal Article Childhood prevention of coronary heart disease Get access J K Lloyd, J K Lloyd Professor St George's Hospital Medical School, University of London, London, UK Correspondence and present address: Professor J.K. Lloyd, M.D., F.R.C.P., Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Search for other works by this author on: Oxford Academic Google Scholar R J West R J West Senior Lecturer St George's Hospital Medical School, University of London, London, UK Search for other works by this author on: Oxford Academic Google Scholar Postgraduate Medical Journal, Volume 62, Issue 724, February 1986, Pages 97–100, https://doi.org/10.1136/pgmj.62.724.97 Published: 01 February 1986
Room-Temperature Bonding Using Mechanical Caulking Effect of Compliant Bumps for Chip-Stack Interconnection

Field: Engineering (Physical Sciences)

We propose room-temperature three-dimensional (3D) chip-stacking using the mechanical caulking effect of compliant bumps. The compliant bumps were cone-shaped bump made of Au. By caulking Au cone bumps with doughnut-shaped electrodes also made of Au, high-density large-number inter-chip connections were realized even at room temperature in ambient air. The number of inter-chip connections realized was 30,600 with 20 µm pitch. Material analysis revealed that Au cone bumps bonded to Au doughnut-shaped electrodes at the atomic level.
Fibrinolytic (rt-PA) therapy for superior vena cava thrombosis in a multiple trauma patient.

Field: Medicine (Health Sciences)

An adult multiple trauma patient (head injury with coma, blunt chest trauma, bone and pelvis fractures) developed superior vena cava thrombosis which extended to the right atrium as a complication of central venous catheterism. Since a four day heparin therapy was unsuccessful, the patient was treated with recombinant tissue-type plasminogen activator (rt-PA), 100 mg over three hours. Thrombolysis with rt-PA was not associated with cutaneous or internal bleeding and was partially effective (improvement of the clinical picture, disappearance of the right atrium thrombus, superior vena cava still occluded). Although our patient could have benefited from an additional administration of rt-PA, we did not start a second course because the risk of major hemorrhage increases over 100 mg. For its relative clot-selectivity rt-PA could be indicated when fibrinolytic treatment is required in multiple trauma patient, but safe and more efficacious regimens have still to be defined.
Defining Kawasaki Disease and Pediatric Multi-Inflammatory Syndrome During SARS-CoV-2 Epidemic in Italy: Results From A National, Multicenter Survey.

Field: Medicine (Health Sciences)

Abstract Background: There is mounting evidence on the existence of a Pediatric Multi-inflammatory Syndrome related to SARS-CoV-2 (PIMS-TS), sharing similarities with Kawasaki Disease (KD). The main outcome of the study were to better characterize the clinical features and the treatment response of PIMS-TS and to explore its relationship with KD determining whether KD and PIMS are two distinct entities. Methods: The Rheumatology Study Group of the Italian Pediatric Society launched a survey to enroll patients diagnosed with KD (Kawasaki Disease Group – KDG) or KD-like (Kawacovid Group - KCG) disease. Demographic, clinical, laboratory data, treatment information, and patients’ outcome were collected in an online anonymized database (RedCAP). Relationship between clinical presentation and SARS-CoV-2 infection was also taken into account. Chi square test or exact Fisher test and non-parametric Wilcoxon Mann-Whitney test were used to study differences between two groups Results: One-hundred-forty-nine cases were enrolled, (96 KDG and 53 KCG). KCG children were significantly older and presented more frequently from gastrointestinal and respiratory involvement. Cardiac involvement was more common in KCG, with 60,4% of patients with myocarditis and 37,8% with hypotension/non-cardiogenic shock. Coronary artery abnormalities (CAA) were more common in the KDG. The risk of ICU admission were higher in KCG. Lymphopenia, higher CRP levels, elevated Ferritin and Troponin-T characterized KCG. KDG received more frequently immunoglobulins (IVIG) and acetylsalicylic acid (ASA) (81,3% vs 66%; p=0.04 and 71,9% vs 43,4%; p=0.001 respectively) as KCG more often received glucocorticoids (56,6% vs 14,6%; p<0.0001). SARS-CoV-2 assay more often resulted positive in KCG than in KDG (75,5% vs 20%; p<0.0001). Short-term follow data showed minor complications. Comparing KDG with a KD-Historical Italian cohort (598 patients), no statistical difference was found in terms of clinical manifestations and laboratory data. Conclusion: Our study suggests that SARS-CoV-2 infection might determine two distinct inflammatory diseases in children: KD and PIMS-TS. Older age at onset and clinical peculiarities like the occurrence of myocarditis characterize this multi-inflammatory syndrome. Our patients had an optimal response to treatments and a good outcome, with few complications and no deaths.
Giant asymptomatic borderline ovarian tumor in a patient suffering from choledocholithiasis and cholangitis

Field: Medicine (Health Sciences)

Borderline tumors account for about 15% of all ovarian epithelial tumors and are usually diagnosed only when they reach a significant size causing abdominal pain or distension. Clinical, sonographic and Doppler examinations, as well as tumor marker levels cannot detect this type of ovarian tumor with certainty. The definitive diagnosis can only be established by a histopathological examination. We present a case of a 58-year-old patient operated on at our clinic for asymptomatic borderline ovarian tumor. Prior to admission, the patient underwent a medical check-up at the surgery department, where she was diagnosed with choledocholithiasis, and, consequently, the need for urgent surgical treatment for calculosis was excluded. In the presented case the ovarian tumor was revealed owing to the occurrence of choledocholithiasis and cholangitis. The choledocholithiasis and cholangitis, which contributed to the accurate diagnosis of the tumor, were at the same time some of the possible reasons for misleading diagnosis and therapy complications in our patient?s case.
Connection-based Processing-In-Memory Engine Design Based on Resistive Crossbars

Field: Computer Science (Physical Sciences)

Deep neural networks have successfully been applied to various fields. The efficient deployment of neural network models emerges as a new challenge. Processing-in-memory (PIM) engines that carry out computation within memory structures are widely studied for improving computation efficiency and data communication speed. In particular, resistive memory crossbars can naturally realize the dot-product operations and show great potential in PIM design. The common practice of a current-based design is to map a matrix to a crossbar, apply the input data from one side of the crossbar, and extract the accumulated currents as the computation results at the orthogonal direction. In this study, we propose a novel PIM design concept that is based on the crossbar connections. Our analysis on star-mesh network transformation reveals that in a crossbar storing both input data and weight matrix, the dot-product result is embedded within the network connection. Our proposed connection-based PIM design leverages this feature and discovers the latent dot-products directly from the connection information. Moreover, in the connection-based PIM design, the output current range of resistive crossbars can easily be adjusted, leading to more linear conversion to voltage values, and the output circuitry can be shared by multiple resistive crossbars. The simulation results show that our design can achieve on average 46.23% and 33.11% reductions in area and energy consumption, with a merely 3.85% latency overhead compared with current-based designs.
Rupture of a True Aneurysm of the Posterior Meningeal Artery at Its Anomalous Origin from the Internal Carotid Artery: Case Report

Field: Medicine (Health Sciences)

The posterior meningeal artery (PMA) usually originates from the third segment of the vertebral artery. Many variations in its origin and course have been observed; however, as far as we know, the association of true aneurysm of the PMA and its anomalous origin from the internal carotid artery has not been reported previously. We reported the case of a 59-year-old woman who suddenly presented a loss of consciousness without head trauma, computed tomography (CT) revelated intracerebellous hematoma associated with a subarachnoid hemorrhage of the posterior cerebral fossa. Cerebral angiography demonstrated a true aneurysm of the PMA which originated from the internal carotid artery.
Analysis of the effect of multiplicative noise on the conditions of signal resolution according to a statistical criterion

Field: Mathematics (Physical Sciences)

We analyzed the effect of multiplicative noise on signal resolution characteristics when a statistical criterion for processing is used in the receiving device. The receiver is optimal for resolving two signals in the sense of detecting against the background of additive white noise. It is shown that the complex envelope of the signal at the output of the analyzed receiver can be considered as a flat vector with correlated components having different variances. However, with fast multiplicative noise, the named components become uncorrelated, and their variances become equal. It is shown that the delay time resolution intervals and frequency shift resolution intervals with known statistical characteristics of signals, additive and multiplicative noise are uniquely determined by the probabilities of correct and false resolution. It is pointed out that the use of a statistical criterion allows us to determine quantitative values of resolution intervals in a fairly wide range of changes in the parameters of additive and multiplicative noise, significantly exceeding the Woodward criterion for example. Thus, the use of statistical criteria leads to an increase in the efficiency of radio systems.
Management of Angle-supported Intraocular Lens and Iridectomy in Descemet-Stripping Endothelial Keratoplasty

Field: Medicine (Health Sciences)

Effective tamponade of a Descemet-stripping endothelial keratoplasty graft with a gas bubble requires that there is no route for the bubble to escape into the posterior chamber.Exchange the angle-supported anterior-chamber intraocular lens (IOL) for an iris-enclaved Artisan IOL and position the IOL haptics over the peripheral iridectomy to occlude it to the extent that no gas can pass.
Treatment of Temperature and Pressure Profiles along the Wellbore to Determine Gas Rate

Field: Energy (Physical Sciences)

Abstract Gas flow profile along the wellbore is an important piece of information for reservoir management purposes, since it provides flow contribution from each producing interval along the wellbore, which is critical for optimizing well performance and maximizing recovery of reserves. Traditional methods are expensive, particularly in high temperature wells and involve running production logsging tools (PLT's) along with flowmeters. Deployment of production logging tools into a well can be operationally difficult and typically requires flow to be suspended temporarily to allow the tools to be run in hole. This can have a negative impact on the quality of data collected, potentially making it un-representative of normal producing conditions. A simple and effective method of the gas rate prediction from temperature and pressure data is discussed in this paper. Solving the inverse problem allows determination of the flow rate and thermal conductivity of the formation by matching the gas pressure and temperature distributions with measured profiles. The results of field data treatment show good agreement with the model prediction and are consistent with flowmeter (PLT) data. Besides, the approximate estimate from direct averaging using the measured data shows good accuracy of rate and thermal conductivity prediction.
Faculty Opinions recommendation of Transcriptional mapping of the primary somatosensory cortex upon sensory deprivation.

Field: Neuroscience (Life Sciences)

Experience-dependent plasticity (EDP) is essential for anatomical and functional maturation of sensory circuits during development.Although the principal synaptic and circuit mechanisms of EDP are increasingly well studied experimentally and computationally, its molecular mechanisms remain largely elusive.EDP can be readily studied in the rodent barrel cortex, where each "barrel column" preferentially represents deflections of its own principal whisker.Depriving select whiskers while sparing their neighbours introduces competition between barrel columns, ultimately leading to weakening of intracortical, translaminar (i.e., cortical layer (L)4-to-L2/3) feed-forward excitatory projections in the deprived columns.The same synapses are potentiated in the neighbouring spared columns.These experience-dependent alterations of synaptic strength are thought to underlie somatosensory map plasticity.We used RNA sequencing in this model system to uncover cortical-column and -layer specific changes on the transcriptome level that are induced by altered sensory experience.Column-and layer-specific barrel cortical tissues were collected from juvenile mice with all whiskers intact and mice that received 11-12 days of long whisker (C-row) deprivation before high-quality RNA was purified and sequenced.The current dataset entails an average of 50 million paired-end reads per sample, 75 base pairs in length.On average, 90.15% of reads could be uniquely mapped to the mm10 reference mouse genome.The current data reveal the transcriptional changes in gene expression in the barrel cortex upon altered sensory experience in juvenile mice and will help to molecularly map the mechanisms of cortical plasticity.
Inhibitory effect of microRNA-149-5p in the proliferation and migration of HepG2 and Bel-7402 hepatoma cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ObjectiveTo investigate the expression of microRNA-149-5p (miR-149-5p) in liver cancer tissue and its molecular and biological role in hepatoma cells. MethodsA total of 65 liver cancer tissue samples and corresponding adjacent tissue samples were collected from January 2010 to January 2014, in the Affiliated Hospital of Inner Mongolia Medical University. Quantitative real-time PCR was used to measure the expression of miR-149-5p in liver cancer tissue and corresponding adjacent tissue. The cells were divided into two groups; the cells in the experimental group were transfected with miR-149-5p mimic, and those in the control group were transfected with the negative control of the mimic. MTT colorimetry and wound-healing assay were performed to determine the effect of miR-149-5p on the proliferation and migration of HepG2 and Bel-7402 cells. The t-test or a one-way analysis of variance was used for comparison of continuous data between groups. ResultsThe liver cancer tissue had significantly lower expression of miR-149-5p than the adjacent tissue (0.14±0.06 vs 2.56±0.42, t=7.79, P＜0.05). There were significantly differences in the expression of miR-149-5p in HepG2(1.43±0.25)、Bel-7402(1.77±0.32), and the normal hepatic epithelial cells(5.68±0.74)(F=11.27，P＜005）. The in vitro functional experiment showed that miR-149-5p mimic significantly inhibited the proliferation of 24、48、72 hour of HepG2 and Bel-7402 hepatoma cells (HepG2: t=498，517，778，all P＜0.05; Bel-7402:t=683,709,1567,all P＜005) and inhibited the migration of HepG2 and Bel-7402 hepatoma cells(t=23.11, 17.42, both P＜005). ConclusionThe expression of miR-149-5p is downregulated in liver cancer tissue, and overexpressed miR-149-5p can inhibit the proliferation and migration of hepatoma cells, suggesting that miR-149-5p may be a promising and effective molecular target for the genetic treatment of liver cancer.
Determination of nuclear charge radius by extreme-ultraviolet spectroscopy of Na-like ions

Field: Physics and Astronomy (Physical Sciences)

We report on a method for determining the absolute nuclear charge radius of high-Z elements using extreme-ultraviolet spectroscopy of highly charged Na-like ions in tandem with highly accurate atomic structure calculations of transition energy differences. The application of this method has reduced the nuclear charge radius uncertainty of Ir191 by a factor of 8 from the currently accepted literature value, with a recently reported charge radius of 5.435(12) fm. The result reduces the charge radius uncertainty along the full Ir isotopic chain when combined with prior optical isotope shift measurements. The technique utilizes only a few million ions stored in an ion trap, which should apply to measurements with small quantities of radioactive nuclei.
The relationship between hopelessness and perceived social support levels of parents with children with congenital heart disease

Field: Health Professions (Health Sciences)

Objective: This study was conducted to evaluate the relationship between hopelessness and perceived social support levels of parents with children with congenital heart disease (CHD). Material and Methods: This cross-sectional study was conducted with parents of children who underwent surgery for CHD, and data were collected from 100 parents who agreed to participate in the study. A descriptive information form for the sociodemographic characteristics of the parents, “Beck Hopelessness Scale (BHS)” and “Multidimensional Scale of Perceived Social Support (MSPSS)” were used to collect the data. Data were analysed using descriptive statistics and Spearman’s correlation tests. Results: The mean score of the hopelessness level of the parents participating in the study was 6.15±4.23, and the mean perceived general social support score was 69.55±15.47. There was a significant negative correlation between the hopelessness levels of mothers and social support (SS) received from the family, from significant others, and general SS scores. There was a significant positive correlation between the hopelessness levels of the mothers and the SS level received from the family (p<0.05). Conclusion: In this study, the parents of children with CHD have low levels of hopelessness and perceived SS levels are high. Moreover, the relationship between hopelessness and perceived SS levels varies according to the sex of the parents. In our study, the SS level of mothers had a higher effect on the hopelessness level. It is recommended that the SS levels of the parents of children with CHD should be increased to help them cope with hopelessness.
The new complete guide to beekeeping

Field: Agricultural and Biological Sciences (Life Sciences)

Covering the rearing of queens, honey-making methods, honey marketing, the benefit of pollinator rental, and everything else related to beekeeping, The New Complete Guide to Beekeeping explains step-by-step what it takes to establish a thriving hive that produces an amazing end product, and all the simple pleasures of beekeeping along the way. Whether you capture a native colony from a hollow tree (a method only for the brave!), adopt a hive from someone who has too many (a much easier method), or start from scratch by buying a queen and purchasing worker bees by the pound, this is a comprehensive guide to making your endeavor successful and even profitable. Whole chapters are dedicated to: the best plants for honey production; seasonal hive management; pests and predators; pollination; honey bee biology; and finding more information from government and public sources.
GAMBARAN KADAR LDL PADA REMAJA OBES DI MINAHASA

Field: Medicine (Health Sciences)

Abstract: Obesity is commonly found in Indonesian including elderly, teenagers, and children. Besides genetic factor, there are some other factors that cause obesity inter alia lifestyle with unhealthy food consumption. Foods such as fatty meat contains low density lipoprotein (LDL) cholesterol which might adversely affect our condition since the early age. This was a descriptive study with a cross sectional design conducted at SMK Negeri 2 and 3 in Tondano Minahasa. Sampels were 54 obese teenagers. The results showed that half of the obese students had above normal LDL cholesterol level.Keywords: teenagers, obese, LDLAbstrak: Obesitas merupakan hal yang sering dijumpai di Indonesia dan mengenai berbagai lapisan usia baik tua, muda, remaja, bahkan usia lanjut. Obesitas terjadi bukan saja terjadi karena faktor genetik, tetapi dapat juga disebabkan antara lain oleh pola hidup daan kebiasaan makan yang tidak sehat. Daging yang berlemak mengandung kolesterol low density lipoprotein (LDL) yang berpengaruh buruk bagi kesehatan bila tidak ditanggulangi sejak usia dini. Penelitian ini menggunakan metode deskriptif dengan desain potong lintang dan dilakukan terhadap remaja obes di SMK Negeri 2 dan 3 di Kabupaten Minahasa. Hasil penelitian menunjukkan bahwa 50% remaja obes di Kabupaten Minahasa memiliki nilai kadar LDL yang lebih tinggi dari batas normal.Kata kunci: remaja, obes, LDL
Detection of free circulating Epstein-Barr virus DNA in plasma of patients with Hodgkin’s disease

Field: Medicine (Health Sciences)

CONTEXT AND OBJECTIVE: Free circulating Epstein-Barr virus (EBV) DNA is often present in the plasma of Hodgkin’s disease patients. The aim here was to evaluate the prevalence of this finding, its correlation with the immunohistochemical expression of LMP-1 (latent membrane protein 1) and the influence of other clinical factors. DESIGN AND SETTING: Prospective study in two public tertiary institutions: Hematology Service, Universidade Federal do Rio de Janeiro, and Oncology Service, Instituto Nacional do Câncer, Rio de Janeiro. METHODS: A cohort of 30 patients with newly diagnosed Hodgkin’s disease was studied. The control group consisted of 13 healthy adult volunteers. EBV DNA was determined by conventional polymerase chain reaction (PCR). RESULTS: The median age was 28 years, and 16 patients were women. Advanced disease was present in 19 patients, and six were HIV-positive. EBV DNA was present in the plasma of 13 patients and one control (43% versus 8%, p = 0.03). EBV DNA prevalence was higher in HIV-positive patients (100% versus 29%, p = 0.0007) and those with advanced disease (63% versus 9%, p = 0.006). Among HIV-negative patients alone, EBV DNA prevalence remained higher in those with advanced disease. EBV DNA was found in 10/11 patients with LMP-1 expression in the lymph nodes, and in 3/19 without LMP-1 expression (kappa coefficient = 0.72). CONCLUSION: EBV DNA was present in 91% of patients with EBV-associated Hodgkin’s disease, and in all patients with HIV-associated Hodgkin’s disease. EBV DNA prevalence was higher in patients with advanced disease, irrespective of HIV status.
Quantification of dependencies in electrical and information infrastructures: The CRUTIAL approach

Field: Engineering (Physical Sciences)

In this paper we present the CRUTIAL approach to model and quantify (inter)dependencies between the Electrical Infrastructure (EI) and the Information Infrastructures (II) that implements the EI control and monitoring system. The quantification is achieved through the integration of two models: one that concentrates more on the structure of the power grid and its physical quantities and one that concentrates on the behaviour of the control system supported by the II. The modelling approach is exemplified on a scenario whose goal is to study the effects of a II partial failure (a denial of service attack that compromises the communication network) on the remote control of the EI.