jimnoneill/paper-to-field-training huggingface dataset:
Solubility of Diborane- and Boron-containing Lithium Salts1

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubility of Diborane- and Boron-containing Lithium Salts1J. R. Elliott, W. L. Roth, G. F. Roedel, and E. M. BoldebuckCite this: J. Am. Chem. Soc. 1952, 74, 20, 5211–5212Publication Date (Print):October 1, 1952Publication History Published online1 May 2002Published inissue 1 October 1952https://pubs.acs.org/doi/10.1021/ja01140a507https://doi.org/10.1021/ja01140a507research-articleACS PublicationsRequest reuse permissionsArticle Views218Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Formulation and Optimization of Orally Disintegrating Tablets of Sumatriptan Succinate

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The aims of the present research were to mask the intensely bitter taste of sumatriptan succinate and to formulate orally disintegrating tablets (ODTs) of the taste masked drug. Taste masking was performed by coating sumatriptan succinate with Eudragit EPO using spray drying technique. The resultant microspheres were evaluated for thermal analysis, yield, particle size, entrapment efficiency and in vitro taste masking. The tablets were formulated by mixing the taste masked microspheres with different types and concentrations of superdisintegrants and compressed using direct compression method followed by sublimation technique. The prepared tablets were evaluated for weight variation, thickness, hardness, friability, drug content, water content, in vitro disintegration time and in vitro drug release. All the tablet formulations disintegrated in vitro within 37-410 s. The optimized formulation containing 5% Kollidon CL-SF released more than 90% of the drug within 15 min and the release was comparable to that of commercial product (Suminat®). In human volunteers, the optimized formulation was found to have a pleasant taste and mouth feel and disintegrated in the oral cavity within 41 s. The optimized formulation was found to be stable and bioequivalent with Suminat®.
A study on patient satisfaction in a batch allocation environment

Field: Decision Sciences (Social Sciences)

The purpose of this paper is to study the queuing problem in Singapore’s healthcare system and increase patient satisfaction by improving their queuing experience. This paper investigates the impact of waiting time and serving order of patients on their satisfaction as well as the relationship between batch size and the two factors. For this purpose, existing published materials were studied to identify candidates for significant factors, after which information was collected from two sources. First, faceto- face interviews were conducted with the doctors and staff at the NTU Clinic to understand the current situation and strategies implemented. Second, a survey was conducted in Nanyang Technological University. Based on the survey results, a simulation was run to find the optimal value of batch size to minimize the operation and reneging cost of the clinic as well as the opportunity cost of the patients.
Biologically Inspired Design Of Small Flapping Wing Air Vehicles Using Four-Bar Mechanisms And Quasi-steady Aerodynamics

Field: Engineering (Physical Sciences)

In this paper, the energetics of a flapping wing micro air vehicle is analyzed with the objective of design of flapping wing air vehicles. The salient features of this study are: (i) design of an energy storage mechanism in the air vehicle similar to an insect thorax which stores part of the kinetic energy of the wing as elastic potential energy in the thorax during a flapping cycle; (ii) inclusion of aerodynamic wing models using blade element theory and inertia of the mechanism using rigid body modeling techniques; (iii) optimization of parameters of the energy storage mechanism using the dynamic models so that the peak power input from the external actuators during a flapping cycle is minimized. A series of engineering prototypes based on these studies have been fabricated which justify the use of these mathematical techniques.
DataSheet1_The antidepressant effect of short- and long-term zinc exposition is partly mediated by P2X7 receptors in male mice.pdf

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

<p>Background: As a member of the purinergic receptor family, divalent cation-regulated ionotropic P2X7 (P2rx7) plays a role in the pathophysiology of psychiatric disorders. This study aimed to investigate whether the effects of acute zinc administration and long-term zinc deprivation on depression-like behaviors in mice are mediated by P2X7 receptors.</p><p>Methods: The antidepressant-like effect of elevated zinc level was studied using a single acute intraperitoneal injection in C57BL6/J wild-type and P2rx7 gene-deficient (P2rx7 −/−) young adult and elderly animals in the tail suspension test (TST) and the forced swim test (FST). In the long-term experiments, depression-like behavior caused by zinc deficiency was investigated with the continuous administration of zinc-reduced and control diets for 8 weeks, followed by the same behavioral tests. The actual change in zinc levels owing to the treatments was examined by assaying serum zinc levels. Changes in monoamine and brain-derived neurotrophic factor (BDNF) levels were measured from the hippocampus and prefrontal cortex brain areas by enzyme-linked immunosorbent assay and high-performance liquid chromatography, respectively.</p><p>Results: A single acute zinc treatment increased the serum zinc level evoked antidepressant-like effect in both genotypes and age groups, except TST in elderly P2rx7 −/− animals, where no significant effect was detected. Likewise, the pro-depressant effect of zinc deprivation was observed in young adult mice in the FST and TST, which was alleviated in the case of the TST in the absence of functional P2X7 receptors. Among elderly mice, no pro-depressant effect was observed in P2rx7 −/− mice in either tests. Treatment and genotype changes in monoamine and BDNF levels were also detected in the hippocampi.</p><p>Conclusion: Changes in zinc intake were associated with age-related changes in behavior in the TST and FST. The antidepressant-like effect of zinc is partially mediated by the P2X7 receptor.</p>
The performance of animals on leaves diet

Field: Agricultural and Biological Sciences (Life Sciences)

This book presents a study that was carried out to evaluate the performance and nutrient digestibility of Red Sokoto bucks fed unwilted and wilted leaves of three browse plant species, namely: Adenodolichos paniculatus, Ficus thnoningii and Gmelina arborea. Livestock production transcends other sectors as key food and economic activity for many communities of Nigeria. Nevertheless, livestock production has been faced with major challenges of feed deficits, especially in the dry periods. One of the recommended practices to overcome challenges of feed deficits is the use of browse plants, especially during the dry season. Browse plants are available all year round because of their drought resistance, persistence, vigorous growth, re-growth and palatability (Crowder and Chheda, 1982). Browse plants are also found all year round in contrast to grasses which rapidly deteriorate with maturity increasing fiber and decreasing protein.
New Approach In Diagnostics Method For Milling Process Using Envelope Analysis

Field: Engineering (Physical Sciences)

This paper proposes a method to vibration analysis in order to on-line monitoring and predictive maintenance during the milling process. Adapting envelope method to diagnostics and the analysis for milling tool materials is an important contribution to the qualitative and quantitative characterization of milling capacity and a step by modeling the three-dimensional cutting process. An experimental protocol was designed and developed for the acquisition, processing and analyzing three-dimensional signal. The vibration envelope analysis is proposed to detect the cutting capacity of the tool with the optimization application of cutting parameters. The research is focused on Hilbert transform optimization to evaluate the dynamic behavior of the machine/ tool/workpiece.
Architects' Attitudes Toward Advertising

Field: Business, Management and Accounting (Social Sciences)

This paper reports the results of a national study of architects' attitudes toward advertising their services. A mail survey was used to collect the data from a randomly selected samvle of architects. Analysis of Ule results using percentages, means; and Mul- tide Discriminant Analvsis revealed an overall consistent vattern of nigative attitudes towaid advertising by architects. ~owt:'ver, here were significant differences among respondents when sepiuated into favorablelunfavorable attitudes subgroups. Respondents with more favorable attitudes toward advertising were: (1) younger, (2) had used an advertising agency, (3) felt marketing was productive, and (4) spent larger proportions of their revenue on marketing activities.
Abstract 39: Fate Of Renin Cell Progenitors In The Developing Kidney Vasculature

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The unique spatial arregement of the kidney arterioles is an essential event for its development. However, the mechanisms that govern this process are still poorly understood. During nephrogenesis, a group of stromal cells expressing the Forkhead Box D1 ( FoxD1 ) transcription factor (TF) will give rise to the metanephric progenitors for the mural cells of the kidneys arteries and arterioles. We aim to identify the core TFs involved in the cell fate along the differentiaton pathways of the developing kidney vasculature. Therefore, we generated Foxd1-cre; mTmG mice, whose Foxd1 derivative cells are labeled with green fluorescent protein (GFP). GFP+ cells were isolated from 5 (P5) or 30 (P30) days old mice kidneys, and processed either for single-cell RNA-Seq (scRNA-Seq) or for single-cell Assay for Transposase-Accessible Chromatin (scATAC-Seq ). The top5 highly expressed TFs on scRNA-Seq at P5 are: Tcf21, Zeb2, Meis2, Cebpd and Nme3 (p_adjusted_value(padj)= 0, 3.8E-187, 3.9E-180, 4E-172, 4.1E-172 and 3.2E-154, respectively). They are involved in developmental processes and cell proliferation. At P30, the top5 highly expressed TFs are: Atf3, klf2, Fos, Nr4a2 and Junb (padj= 4.2E-294, 2.1E-200, 3.5E-182, 1.7E-52 and 0.2E-24, respectively). They are implicated with calcium-signaling pathway and inflammation. Additionally, scATAC-Seq identifies regions of accessible chromatin for pontential TFs binding, leading to changes in gene expression content and cell identity. At P30, scATAC-Seq showed differential accessible regions with subsequent putative motif enrichment analysis for the TF N4a2 (padj: 4E-297). This is in accordance with our scRNA-Seq results and might play a role in the Foxd1 progenitors cell fate decisions. Our results tracks the fate of the Foxd1+ cells during the kidney vasculature assembly and suggest a new transcription factors network that might play a role to orchestrate cell fate decisions during kidney vascular development.
Lawyering for the Rule of Law

Field: Social Sciences (Social Sciences)

Lawyering for the Rule of Law introduces a new model of government lawyering in which government lawyers function as an ancillary mechanism that enables the court to expand its influence on policy-making within the political branches by forming out-of-court settlements. It discusses the centrality of government lawyers with regard to judicial mobilization and the enforcement of social reforms through adjudication, and sheds light on particular functions of government lawyers as adjudicators and facilitators of institutional arrangements. It also discusses the ethical and professional dilemmas of government lawyers in judicial review and the relationship between lawyers' professional morality and outcomes in litigation.
Analysis of Seismicity in the Juncture Region of Tibet,Qinghai,Sichuan and Yunnan Provinces

Field: Earth and Planetary Sciences (Physical Sciences)

Since 1955,the siesmicity with M≥5.0 in the juncture region of Tibet,Qinghai,Sichuan and Yunnan provinces has been in a alternate rhythm state of quietude and activity.In this paper,the 10 whole quiet-active periods are discussed.Some phenomena represented by the 10 periods,and their correlative relations with the seismicity in a large area of Tibet-Qinghai Block are discussed also.
Bonded silicon-on-sapphire wafers and devices

Field: Materials Science (Physical Sciences)

Silicon-on-sapphire (SOS) has been prepared by direct wafer bonding. The silicon layer was thinned to about 10 μm by mechanical grinding and chemical etching. P-N junction diodes were fabricated in the bonded SOS and compared with epitaxially grown SOS. The reverse bias leakage current was almost 15× less in the bonded SOS. A generation lifetime of 10 μs can be estimated from the junction leakage. The effects of processing temperatures on the bonded SOS were also studied.
Unveiling the genetic role of skin-gut microbial axis in pan-cancer development.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

e22503 Background: The skin and gut are critical, microbe-rich barriers whose dynamic interplay modulates immune homeostasis and disease susceptibility. Although the gut-skin axis has been well-established in the context of inflammatory bowel diseases, how skin microbial communities shape gut microbial composition and, in turn, influence cancer development remains insufficiently characterized. Methods: We leveraged large-scale genome-wide association (GWAS) data from the skin microbiome dataset, the MiBioGen consortium, and the IEU Open GWAS database to systematically dissect potential causal relationships among 147 skin microbial taxa, 196 gut microbial taxa, and 27 distinct cancer types. Genetic variants with p < 1 × 10⁻⁵ were selected as instrumental variables (IVs). Sensitivity analyses were conducted to ensure the robustness of results, and mediation analysis was applied to assess the role of the skin-gut axis during oncogenesis. Results: Using a bidirectional genetic approach, we identified 14557 IVs for microbial traits, establishing 11,998 significant “skin-to-gut” and 2,559 “gut-to-skin” links. These findings reveal a robust skin–gut microbial axis associated with pan-cancers. A total of 164 “skin-to-cancer” and 211 “gut-to-cancer” associations were unveiled, elucidating the causal effects of skin and gut microbiota on cancer. Notably, Streptococcus salivarius (ASV022_Moist) showed divergent effects on pancreatic (β = 0.102, p = 3.45 × 10⁻²) and endometrial cancers (β = -4.41 × 10⁻⁴, p = 2.91 × 10⁻²), underscoring the complexity of microbial influences across tumors. Mediation analyses further identified 65 significant “skin–gut–cancer” pathways, suggesting that certain taxa operate both as exposures and mediators in oncogenic processes. Together, these results provide genetic evidence that the skin–gut microbial axis constitutes a previously underappreciated determinant of cancer risk. By pinpointing key microbial taxa and bidirectional interactions, our study highlights the potential of targeting both skin and gut microbiota in future cancer prevention and therapeutic strategies. Conclusions: This study provides robust genetic evidence supporting a skin-gut axis influencing cancer risk via complex microbial interactions, underscoring the translational potential of targeting both skin and gut microbiota as a novel therapeutic approach for cancer prevention and treatment, emphasizing the translational relevance of these microbial networks in oncology.
Kinase Inhibitors and Ovarian Cancer

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Ovarian cancer is fifth in the rankings of cancer deaths among women, and accounts for more deaths than any other gynecological malignancy. Despite some improvement in overall-(OS) and progression-free survival (PFS) following surgery and first-line chemotherapy, there is a need for development of novel and more effective therapeutic strategies. In this mini review, we provide a summary of the current landscape of the clinical use of tyrosine kinase inhibitors (TKIs) and mechanistic target of rapamycin (mTOR) inhibitors in ovarian cancer. Emerging data from phase I and II trials reveals that a combinatorial treatment that includes TKIs and chemotherapy agents seems promising in terms of PFS despite some adverse effects recorded; whereas the use of mTOR inhibitors seems less effective. There is a need for further research into the inhibition of multiple signaling pathways in ovarian cancer and progression to phase III trials for drugs that seem most promising.
New synthesis of the 1,3-thiazine ring system

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew synthesis of the 1,3-thiazine ring systemHoward Alper and Edmund C. H. KeungCite this: J. Org. Chem. 1972, 37, 9, 1464–1466Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://pubs.acs.org/doi/10.1021/jo00974a047https://doi.org/10.1021/jo00974a047research-articleACS PublicationsRequest reuse permissionsArticle Views147Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dental Caries in the Cotton Rat. IV. Inhibitory Effect of Fluorine Additions to the Ration.

Field: Dentistry (Health Sciences)

Some inhibition of caries resulted when 45, 90, or 135 p.p.m. of fluorine were ingested as supplements to a sucrose basal ration. Depigmentation of the incisors appeared when 45 or more p.p.m. of fluorine were incorporated in the diet while mottling of the third molars occurred when 225 or more p.p.m. were fed. The ingestion of 225 or 450 p.p.m. of fluorine caused a 90%. decrease in caries incidence. Thus the amount of fluorine necessary to inhibit caries to this degree was sufficiently high to cause mottling of the developing teeth.
Imaging Intracellular Signaling Using Two-Photon Fluorescent Lifetime Imaging Microscopy

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The recent development of Förster resonance energy transfer (FRET) sensors and FRET imaging techniques permits visualization of the dynamics of intracellular signaling events with high spatiotemporal resolution. In particular, fluorescence lifetime imaging in combination with two-photon laser-scanning microscopy (two-photon fluorescence lifetime imaging microscopy [2pFLIM]) is a powerful tool to monitor signaling events in small subcellular compartments in thick tissue. This article provides practical guidelines for quantitative imaging of intracellular signaling using 2pFLIM.
Introduction to Science and Technology Park Activity - Case Study That Focuses on Complementary Support

Field: Business, Management and Accounting (Social Sciences)

The article focuses on the activities of Science and Technology Park, "TECHNOPARK GLIWICE" Ltd. which is one of the best parks in Poland. The park operates for only four years. The article describes the most important projects which has been and are being implemented in Technopark Gliwice. The projects are mainly aimed at students and PhD students of the Silesian University of Technology and the employees of SMEs. The paper also presents the best companies located in the Park and the cooperation between the Park and other institutions of this kind in Poland. Moreover, the paper describes the laboratory equipment of the Park and the services which the Park provides to SMEs with the use of this equipment.
Occurrence Download

Field: Agricultural and Biological Sciences (Life Sciences)

A dataset containing 737466 species occurrences available in GBIF matching the query: { "or" : [ "TaxonKey is Ambystoma tigrinum (Green, 1825)", "TaxonKey is Boa nebulosa (Lazell, 1964)", "TaxonKey is Erythrura gouldiae (Gould, 1844)", "TaxonKey is Chloris chloris", "TaxonKey is Dromaius novaehollandiae (Latham, 1790)", "TaxonKey is Eclectus roratus (Statius Muller, 1776)", "TaxonKey is Eublepharis macularius (Blyth, 1854)", "TaxonKey is Geopelia cuneata (Latham, 1801)", "TaxonKey is Kinosternon scorpioides (Linnaeus, 1766)", "TaxonKey is Lonchura oryzivora (Linnaeus, 1758)", "TaxonKey is Myiopsitta monachus (Boddaert, 1783)", "TaxonKey is Pavo cristatus Linnaeus, 1758" ] } The dataset includes 737466 records from 447 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0023385-210914110416597/datasets/export for details. Data from some individual datasets included in this download may be licensed under less restrictive terms.
Assessment of Anxiety and Local Anesthesia Experiences in Dental Students Using the Modified Dental Anxiety Scale (MDAS)

Field: Health Professions (Health Sciences)

Background and Objectives: Dental anxiety can hinder both treatment delivery and dental education. Few studies have examined this issue among Romanian dental students. This study assessed the prevalence, intensity, and main procedural triggers of dental anxiety, with a focus on experiences related to local anesthesia. Methods: A cross-sectional survey was conducted (January–May 2024) among 122 fourth-year students using the validated Romanian version of the Modified Dental Anxiety Scale (MDAS) and additional items on demographics, prior anesthesia and perceived complications. Data analysis included descriptive statistics, chi-square tests, and t-tests. Results: Overall, 21.3% of respondents scored in the low anxiety range, 75.4% in the moderate range, and 3.3% in the severe range (MDAS ≥ 19). No significant gender differences were identified (p > 0.05). Injections with local anesthetic were rated as the most distressing procedure, followed by drilling, whereas scaling was reported as least stressful. The majority (86.9%) had undergone previous local anesthesia, with very few adverse events recalled. Conclusions: Romanian dental students reported moderate dental anxiety overall, with local anesthesia injections as the main trigger. The lack of gender differences points to a potential buffering effect of clinical exposure. Incorporating structured anxiety management into dental curricula may enhance both student well-being and patient care.