jimnoneill/paper-to-field-training huggingface dataset:
Total CD4+ T cell cytokine positive production by DAR-901, BCG and placebo vaccinated individuals in response to Mtb lysate stimulation at various study timepoints.

Field: Medicine (Health Sciences)

<p>CD4+ T cell expression of IFNγ (a), IL2 (b), TNFα (c), IL17(d), IL22 (e) and any IFNγ+, IL2+,TNFα+ cytokine (f) and any IFNγ+, IL2+,IL17+,IL22+ cytokine (g) in response to Mtb lysate stimulant in the DAR-901 (n = 10), BCG (n = 9) and Placebo (n = 9) vaccinated subject was assessed. The median CD4+ T cell cytokine responses (+IQR) are shown at each visit, after subtraction of the unstimulated levels. Treatment-specific immune responses were calculated by AUC analyses for the longitudinal immune responses for individual participants within each treatment group. The Kruskal-Wallis test (with Dunn’s post hoc test) was used to assess for differences between groups from 7-days until 180-days post dose 3 in total cytokine-producing CD4+ T cells (results shown above). Total median cytokine producing CD4+ T cell responses were compared for differences at baseline, at 7-days post dose 3 and at 180-days post dose 3) using Wilcoxon signed-rank test (results shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0217091#pone.0217091.s001" target="_blank">S1 Table</a>).</p>
A Five-Parameter Family of Positive Kernels from Jacobi Polynomials

Field: Mathematics (Physical Sciences)

The Jacobi polynomials ${}_2 F_1 ( - n,n + \alpha _1 + \alpha _2 + \beta _2 + \beta _3 - 1;\alpha _1 + \beta _2 ;{x / E})$ over the range $[0,E]$, $E > 0$, are used to construct a generally nonsymmetric kernel with five parameters $\alpha _1 $, $\alpha _2 $, $\beta _1 $, $\beta _2 $, $\beta _3 $ whose real parts are taken to be positive. Under further conditions on $\beta _1 $, $\beta _2 $, $\beta _3 $ this kernel is shown to be square-integrable, and even continuous over a wide region of the parameter-space. For real values of the parameters the kernel is shown to be essentially positive. Special limiting kernels are obtained by considering various limiting cases: $\alpha _1 \to 0$, $\alpha _2 \to 0$, $\alpha _2 = E \to \infty $, $\beta _3 = E \to \infty $. Some bilinear sums are obtained involving the Jacobi and Laguerre polynomials.
Comparison of Calcium Content between Blossom-End Rot and Healthy Fruits in Red Pepper (Capsicum annuum L.) Grown in Open Field

Field: Agricultural and Biological Sciences (Life Sciences)

The causes of blossom-end rot (BER) are still not understood clearly, although there was a lot of research on the development of BER over 100 years. This experiment was conducted to investigate the influence of Ca content of fruit on the incidence of BER in red pepper. BER affected fruits and healthy fruits had been harvested and the samples were divided into two parts, the upper and the lower, for chemical analysis to determine the content of mineral nutrients in the tissue. The content of nitrogen (N), phosphorus (P), potassium (K) and magnesium (Mg) was higher in the BER affected fruits and the difference of each nutrient content was revealed much larger in the lower part of the fruit but there were no significant differences in calcium content between the BER and the healthy fruits of red pepper, in this experiment. The results indicate that it is difficult to find a certain relation between the calcium content of the fruit and the occurrence of blossom-end rot.
Convection-UNet: A Deep Convolutional Neural Network for Convection Detection based on the Geo High-speed Imager of Fengyun-4B

Field: Computer Science (Physical Sciences)

Deep convection can cause a variety of severe weather conditions such as thunderstorms, strong winds, and heavy rainfall. Satellite observations provide all-weather and multi-directional observations, facilitating the timely detection of such weather systems, which is crucial to saving lives and property. However, previous methods based on channel feature extraction and threshold filtering did not make full use of information in satellite images, which led to limitations on such complex problems as strong convection detection. In this study, we propose a novel framework of a deep learning-based model Convection-UNet to detect convection. We use channel 4 to 7 of FY-4B GHI that we select according to the microphysical properties of convection as input and radar reflectivity as label. We combine the detailed training time and test time data augmentation strategies and build a deep neural network to automatically extract spatial context features and achieve end-to-end learning. Results show that the performance of our method far exceeds the previous channel extraction combined with threshold filtering methods such as BT and BTD at least 0.24 on Fi-measure. We also show that our channel selection and data augmentation strategies are of great significance to detect convection.
The impact of the presence of hirsutism and hypertrichosis on the psychological state of women suffering from polycystic ovary syndrome and hyperandrogenism

Field: Medicine (Health Sciences)

This review article focuses on analyzing the impact of excessive hairiness, in the form of hirsutism and hypertrichosis, on the psychological state of women affected by polycystic ovary syndrome (PCOS) and hyperandrogenism. PCOS is one of the most common endocrine disorders in women, characterized by hyperandrogenism, insulin resistance and menstrual disorders, among others. Studies suggest that excessive body hair can have a significant impact on the quality of life and psychological state of PCOS patients, leading to lowered self-esteem, depression, anxiety and body dysmorphophobia. Despite numerous clinical observations, however, a complete understanding of the mechanisms underlying this association is lacking. The article underscores the need for further research to identify the biological and psychological mechanisms affecting the psychological state of women with excessive body hair in the context of PCOS and hyperandrogenism. As progress is made in this area, it will be possible to develop more effective management strategies and therapeutic interventions that can help improve the quality of life for these patients.
Evaluating the Efficacy of Sudarshan Kriya Yoga in Health Care: A Systematic Review of Randomized Controlled Trials

Field: Health Professions (Health Sciences)

Background: Sudarshan Kriya Yoga (SKY) is an advanced yogic breathing technique developed by the Art of Living Foundation. Given its widespread use in diverse therapeutic settings, a systematic review of randomized controlled trials (RCTs) was conducted to assess its efficacy in health care. Methods: This review followed the PRISMA guidelines and used the PECO framework. We searched databases such as the Web of Science, Cochrane Library, PubMed, and Scopus from the year 2000 to 2023 using a combination of MeSH phrases and free-text keywords. The inclusion criteria were restricted to RCTs involving any demographic, with SKY as the primary intervention. The risk of bias was assessed using the Cochrane Collaboration’s Risk of Bias 2.0 tool. Results: We included 15 RCTs and synthesized the results using quantitative analysis and qualitative narrative synthesis. The findings demonstrate significant improvements in psychological well-being, especially in stress reduction and emotional regulation across different populations. In addition, SKY also showed potential in managing symptoms of post-traumatic stress disorder and physiological markers such as blood pressure and heart rate variability. Conclusion: SKY effectively improves mental health and physiological parameters, highlighting its potential utility as a non-invasive therapeutic option. Despite its benefits, the studies varied in methodological rigor, indicating the need for further high-quality research to solidify these findings. Yoga, an ancient practice originating from India, has evolved over thousands of years into a popular holistic discipline that unifies body, mind, and spirit.[1] Initially focused on spiritual development and tranquillity, yoga is now globally recognized for enhancing physical flexibility, mental clarity, stress reduction, and overall well-being. As yoga has integrated into Western culture, a variety of styles have emerged, each emphasizing different elements such as physical postures (asanas), meditation (dhyana), and breath control (pranayama). Among these, Sudarshan Kriya Yoga (SKY), developed by the Art of Living Foundation, stands out for its unique use of rhythmic breathing
The impact of monolingual language policies on the multilingual language ecology of Sri Lanka

Field: Social Sciences (Social Sciences)

Abstract This qualitative study examined the role of different languages used in the country in the lives of 12 participants from the four main ethnic groups of Sri Lanka (i.e., Sinhalese, Tamil, Muslim, and Burgher). It sought to understand how monolingual language policies have impacted upon the country's plurilingual language ecology. The study examined the language ideologies of participants to understand how structures of social power have worked through monolingual language policies to influence and shape their language behaviors and practices. While the impact that language policies have had on different Sri Lankan languages has been examined, no study has analyzed it through the point of view of language ideologies of actual speakers of different languages. The observations made by the participants show that the monolingual ideologies of the language policies of 1832 and 1956, by assigning sole official language status to English and Sinhala respectively, have caused them to gain dominance and diminished the status of other languages, thereby altering the plurilingual language ecology of Sri Lanka. Their observations also showed how the 1956 policy's establishment of Sinhala as the dominant language within the language ecology of the country had elevated the position of the majority community—the Sinhalese, and strengthened the power of the then government which had ridden into power through the Sinhalese majority vote. The analysis of data also indicated that, although the 1956 policy was implemented with the aim of dismantling the structures of power introduced during colonial rule, both policies have served to support and reinforce a social hierarchy based on a Western model. What the data revealed about the role that the two monolingual language policies of 1832 and 1956 seem to have played in establishing and reinforcing the dominance of Sinhala and English respectively, suggest that although political subjugation of the country by European powers has officially ended, Sri Lanka continues to operate within the structures of power established during colonial times.
Adsorption of Cesium Radionuclides by the Composite Sorbents Carbon Fiber/Transition Metals Ferrocyanides

Field: Chemistry (Physical Sciences)

Among various methods of cesium removal from aqueous solutions, sorption using transition metals ferrocyanides is the most efficient method due to extremely high affinity of cesium ions to ferrocyanides. The efficiency of transition metals ferrocyanides application is known to depend on the crystal size being the highest for nanocrystals. Although nanocrystals are difficult to handle in direct application, they can be used in composite materials. In this case two main problems arise: how to control the crystal size of transition metals ferrocyanides and fix them reliably in the supporting matrix. Here we suggest a new route to preparation of composite materials selective to cesium ions using transition metals ferrocyanides stabilized by siloxane-acrylate latexes. The size of transition metals ferrocyanides is controlled by the size of latex particles and their stability is determined by ionization of polyacrylic acid carboxylic groups on the functionalized latex surface. These functionalized particles can be used as precursors in preparation of composite materials by sedimentation and polymerization of latexes on the solid surface of porous matrix, e.g. carbon fibers. Several routes of preparation of carbon fiber based composite materials using functionalized latexes and sorption properties of the obtained materials are discussed. The effect of preparation conditions (method used, carbon fiber polarization potential, concentration of latexes functionalized with transition metals ferrocyanides) on cesium uptake by composite sorbents from solutions of various salinity is reported.
Oxaliplatin-induced blood brain barrier loosening: a new point of view on chemotherapy-induced neurotoxicity

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Oxaliplatin is a key drug in the treatment of advanced metastatic colorectal cancer. Despite its beneficial effects in tumor reduction, the most prevalent side-effect of oxaliplatin treatment is a chemotherapy-induced neuropathy that frequently forces to discontinue the therapy. Indeed, along with direct damage to peripheral nerves, the chemotherapy-related neurotoxicity involves also the central nervous system (CNS) as demonstrated by pain chronicity and cognitive impairment (also known as chemobrain), a newly described pharmacological side effect. The presence of the blood brain barrier (BBB) is instrumental in preventing the entry of the drug into the CNS; here we tested the hypothesis that oxaliplatin might enter the endothelial cells of the BBB vessels and trigger a signaling pathway that induce the disassembly of the tight junctions, the critical components of the BBB integrity. By using a rat brain endothelial cell line (RBE4) we investigated the signaling pathway that ensued the entry of oxaliplatin within the cell. We found that the administration of 10 μM oxaliplatin for 8 and 16 h induced alterations of the tight junction (TJs) proteins zonula occludens-1 (ZO-1) and of F-actin, thus highlighting BBB alteration. Furthermore, we reported that intracellular oxaliplatin rapidly induced increased levels of reactive oxygen species and endoplasmic reticulum stress, assessed by the evaluation of glucose-regulated protein GRP78 expression levels. These events were accompanied by activation of caspase-3 that led to extracellular ATP release. These findings suggested a possible novel mechanism of action for oxaliplatin toxicity that could explain, at least in part, the chemotherapy-related central effects.
OUTCOMES OF PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION WITH CHRONIC TOTAL OCCLUSIONS

Field: Medicine (Health Sciences)

This study aimed to assess the efficacy of percutaneous coronary intervention (PCI) with chronic total occlusions (CTO) in a cardiology department in Peshawar, Pakistan, between January 2021 and December 2022. The study included 190 to 200 patients, most of whom had a history of hypertension and diabetes and were predominantly male. The successful CTO-PCI group had significantly lower major adverse cardiac events (MACE) and target vessel revascularization (TVR) rates than the failed CTO-PCI group. Younger age, male gender, absence of previous myocardial infarction, and lower J-CTO score were significant risk factors for CTO PCI success. Long-term outcomes indicated that CTO PCI was linked to lower rates of MACE, TVR, and repeat revascularization compared to non-CTO PCI. These results indicate that CTO-PCI can be a safe and efficient treatment option for patients with chronic total occlusions. Identification of significant risk factors can aid in selecting patients who are likely to benefit from this procedure. Further research is required to confirm these findings and examine the long-term outcomes of CTO-PCI in larger patient cohorts.
Contracts Rather than Deliberation

Field: Economics, Econometrics and Finance (Social Sciences)

Robert Sugden's normative approach is unique in its voluntary neglect of the notion of deliberation. This chapter presents and critiques Sugden's approach. It discusses Sugden's position on public reasoning i.e. public deliberation with rational reasoning. The chapter presents the core of his contractarian position and explores how Sugden's proposals can be psychologically stable, that is how they can receive ever-renewed agreement from each stakeholder. It examines an auxiliary project, which consists of proposing a moral norm, called the principle of mutual advantage, and which participates in, and completes, the contractarian approach. Sugden reviews a number of properties of his principle that are likely to ensure its psychological stability. Among these properties, he mentions the capacity of human beings to be translucent . Notably, Sugden adds another argument to justify the stability of his principle: that of the correspondence of feelings .
Hezekiah to the Babylonian Exile (2 Chronicles 29–36)

Field: Arts and Humanities (Social Sciences)

It is evident that, with the Israelite population partially reunited in its depressed state, the Chronicler's interpretation of Hezekiah's reign will be of paramount importance. To maintain continuity of argument, therefore, we shall treat this subject first in this chapter, before going on to deal with other aspects of his understanding of Israel during this period.
Fast-motion trajectory generation for a new direct-drive planar parallel manipulator

Field: Engineering (Physical Sciences)

A new direct-drive planar parallel robotic manipulator is presented for fast-motion positioning in this paper. Because of the nonlinearity of kinematics and dynamics of the robotic manipulator, the achievable maximum velocity and maximum acceleration vary at different points and directions in the whole workspace. In order to make the manipulator move with fully high velocity and high acceleration along the specified trajectory in the workspace, a fast-motion trajectory generation technique is introduced in detail. Given the limitations on speed and torque of the actuators, the available values of maximum velocity and maximum acceleration along the specified trajectory are firstly derived. Then, based on these values, several motion profiles are generated with different acceleration and deceleration characteristics. Finally, the experiments of trajectory generation are conducted on the new robotic manipulator, which moves along the trajectories with the unsymmetrical velocity profiles, and the results validate the proposed technique
Measurement of ultra-short electron bunch duration by coherent radiation analysis in laser plasma catode

Field: Physics and Astronomy (Physical Sciences)

We have performed measurement of electron bunch duration from laser plasma acceleration. Spectrum analysis of the transition radiation from the electron bunch was selected for measurements, using an IR (infrared) bolometer with different filters first. The bunch is estimated to be 30 fs in PIC simulation, but measured duration was 2 ps by the result of bunch elongation at 340 mm downstream from the plasma edge due to broadness of energy spectrum. And then measurement by In-Sb polychromator aiming shot-by-shot measurement is also done. But the signal of transition radiation cannot be detected by X-ray background signal even if shielding by Pb. So we have done optimisation of X-ray shielding and position of detector.
PENINGKATAN KAPASITAS KUALITAS DAN PEMBERDAYAAN SUMBER DAYA MANUSIA DI DESA JATILUWIH

Field: Social Sciences (Social Sciences)

Jatiluwih, recognized as a UNESCO World Cultural Heritage site in 2012, attracts significant tourist attention. Despite its burgeoning development, the village faces challenges due to a lack of adequately trained human resources. Predominantly, educational attainment in the village is restricted to the secondary level, which limits management knowledge and skills among the residents. The Participatory Rural Appraisal (PRA) method, which involves engaging community groups in the examination of rural conditions, has been employed to address these challenges. This approach seeks to empower non-productive groups to enhance the overall capacity, knowledge, skills, and well-being of Jatiluwih's community, thereby fostering sustainable human resource development and improved socio-economic conditions.
Optimisation of gamma spectrometry measurements in atmosphere during nuclear emergencies

Field: Earth and Planetary Sciences (Physical Sciences)

Abstract During emergencies following a major nuclear accident a prompt and accurate characterisation of the radioactive cloud is one of the main task of any radioactivity monitoring system. This task is usually performed by means of γ-spectrometry High Purity Germanium (HPGe) measurements on atmospheric particulate samples gathered by means of high-volume pumps. The key parameters describing the performances of a monitoring system are the Minimum Detectable Activities (MDAs) of the most relevant radionuclides. These parameters depend on a number of factors related to the efficiency of the available germanium detector, the volume of air filtered by the sampling devices and the γ-decay scheme of each radionuclides as well. Besides the MDAs, another very important characteristic of a monitoring system, especially during an evolving emergency, is its capability of giving reliable results at a given and constant pace. It is therefore important to define the time resolution of the monitoring system, i.e. the minimum time needed to produce the data, namely the activity concentrations of the radionuclides in the atmosphere. The optimization of the measurements procedures are discussed in this work: in particular it is demonstrated that, being t the time resolution of the monitoring system, the lowest MDAs can be achieved with a sampling time given by (2/3)·t and a counting time of (1/3)·t. Finally, the MDAs achievable for a standard monitoring system based on a 30% HPGe detector are calculated for all the most important fission products.
Supplementary Table from A Phase I Trial of CT900, a Novel α-Folate Receptor–Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer

Field: Medicine (Health Sciences)

Supplementary Table from A Phase I Trial of CT900, a Novel α-Folate Receptor–Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer