jimnoneill/paper-to-field-training huggingface dataset:
Harnessing Antibody-Mimetic Selectivity for Activation-State-Specific Targeted Degradation of Endogenous K-Ras

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVFirst ReactionsNEXTHarnessing Antibody-Mimetic Selectivity for Activation-State-Specific Targeted Degradation of Endogenous K-RasInducible anti-Ras biodegraders as biological tools to interrogate nucleotide-loaded states across a panel of K-Ras mutants are developed.Fleur M. Ferguson​Fleur M. FergusonDepartment of Chemistry & Biochemistry, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093-0657, United StatesE-mail: [email protected]More by Fleur M. Fergusonhttp://orcid.org/0000-0003-4091-7617Cite this: ACS Cent. Sci. 2021, 7, 2, 222–224Publication Date (Web):January 25, 2021Publication History Published online25 January 2021Published inissue 24 February 2021https://doi.org/10.1021/acscentsci.1c00084Copyright © Published 2021 by American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceCC: Creative CommonsBY: Credit must be given to the creatorNC: Only noncommercial uses of the work are permittedND: No derivatives or adaptations of the work are permittedArticle Views1719Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-AlertsSUBJECTS:Degradation,Peptides and proteins,Genetics,Cells,Selectivity Get e-Alerts
Determination of Aflatoxin M1 levels in Turkish cheeses provided from different regions of Turkey

Field: Agricultural and Biological Sciences (Life Sciences)

Hygienic quality is a very important problem in milk and dairy products. Aflatoxins are produced by moulds, and it is known that the Aflatoxin M1 type, which can be found in milk and dairy products, is a potential risk for public health. In this study, the presence of Aflatoxin M1 in white and Tulum cheese samples collected from three different provinces of Turkey (Burdur, Bursa, and Elazig) was investigated with the ELISA method. 42 white and 42 Tulum cheese samples (total 84) were analyzed, and the samples were evaluated in terms of their compliance with the limits of the Turkish Food Codex. According to the results; 34 (40.47 %) of 84 cheese samples were contaminated with Aflatoxin M1, ranging from 250 to 559 ng/kg. Fifty (59.52 %) cheese samples were found below the detection limit, meaning they are negative in terms of Aflatoxin M1 and do not pose a risk. On the other hand, 2 samples (2.38 %) were over the tolerance limit of the Turkish Food Codex. Also, the incidence of Aflatoxin M1 in white cheeses was 35.71 % and 45.23 % in Tulum cheeses. Although it is not much above the legal limit, Aflatoxin M1 contamination in cheese may reduce the food quality and adversely affect human health. Therefore, it should be treated more carefully in the production of milk and dairy products. In addition, quality feeds should be used in the feeding of dairy animals.
The Role of Teaching Assistance in Enhancing the Learning Motivation of Twelfth-Grade Students in English Literature at SMAN 9 Toraja Utara

Field: Social Sciences (Social Sciences)

This study aims to examine the role of teaching assistance programs in improving the learning motivation of twelfth-grade students in English Literature at SMAN 9 Toraja Utara. The program, part of the Merdeka Belajar Kampus Merdeka (MBKM) initiative, involves university students assisting teaching activities in schools to support literacy, numeracy, technology adaptation, and administrative tasks. Using a descriptive qualitative approach, data were collected through observation, interviews, and documentation over four months. The findings reveal that the teaching assistance program significantly enhances students' interest and enthusiasm in learning. The use of creative methods, such as learning through games and providing rewards, has proven effective in fostering a positive classroom environment and improving academic engagement. Furthermore, the program allows university students to develop essential skills, including leadership, collaboration, and empathy, while contributing to the improvement of teaching quality in schools. This research highlights the importance of innovative educational strategies to support student motivation and academic achievement.
Characteristics of interface-doped MNOS memory devices

Field: Materials Science (Physical Sciences)

The results of an investigation of the characteristics of MNOS memory devices are given in which the interface between the oxide and nitride was doped with a few monolayers of various refractory metals. In particular, write speeds of the order of microseconds could be obtained along with retention times which could be extrapolated to many decades. No temperature dependence could be found for the decay of stored charge between 77 K and 300°C, indicating that retention is normally dominated by Fowler-Nordheim back tunneling from the interface. Long time exposure to high gate voltages and write/erase cycling in excess of 1000 cycles sharply reduces the achievable memory window, and is accompanied by the copious generation of fast surface states, at least in p-channel devices.
Psychoanalysis and the Maltreatment of Children

Field: Psychology (Social Sciences)

This essay presents some of the ideas derived from 30 years of observing and treating abused children and those who abuse them. Although most of these patients have not been in what could be called classical analysis, psychoanalytic principles have been crucially important in understanding their behavior and psychodynamics. I also believe that the study of their life histories can often enhance and sometimes broaden many of our psychoanalytic concepts, especially of ego and superego development and expresssion.
Lattice Codes for Deletion and Repetition Channels

Field: Mathematics (Physical Sciences)

The construction of deletion codes for the editing metric is reduced to the construction of codes over the integers for the Manhattan metric by run length coding. The latter codes are constructed by expurgation of lattices' translates. These lattices, in turn, are obtained from Construction A applied to binary codes and Z 4 -codes. A lower bound on the size of our codes for the Manhattan distance are obtained through generalized theta series of the corresponding lattices. For any fixed number of deletions, provided the number of runs is large enough our method supplies a correction technique. For fixed number of runs and binary sequence length large our lattice construction is shown to be tight up to constants.
Association of Neisseria gonorrhoeae genogroups and specific PBP2/MtrR/PorB mutation patterns with susceptibility to penicillin in a susceptible gonococcal population

Field: Immunology and Microbiology (Life Sciences)

Specific mutation patterns in PBP2/MtrR/PorB were associated with specific GGs and penicillin susceptibility. This approach of typing strains and resistance patterns is ideal for predicting antimicrobial resistance and should be used in instances in which gonococcal culture is not available but DNA can be obtained from clinical specimens.
Evaluating Differences Between Stuttering and Nonstuttering Speakers

Field: Psychology (Social Sciences)

This paper focuses on some suggested analytical indices to be used in group difference studies, specifically in research comparing stuttering with nonstuttering speakers. The introductory material places the group difference design in an historical context and shows its relationship to underlying conceptualizations of the nature of stuttering. The major portion of the paper addresses the development, interpretation, and application of these analytical indices. Finally, limitations of the group difference design are described.
Hydrogen Atom Transfer in Model Reactions

Field: Chemistry (Physical Sciences)

This chapter contains sections titled: Introduction Oxygen-centered Radicals Nitrogen-centered Radicals Generation of Aminyl and Amidyl Radicals Reactions of Aminyl and Amidyl Radicals Sulfur-centered Radicals Thiols and Thiyl Radicals Hydrogen Transfer from Thiols Hydrogen Abstraction by Thiyl Radicals Sulfide Radical Cations Conclusion Acknowledgment References
EMU equity markets' return variance and spillover effects from the short-term interest rate

Field: Economics, Econometrics and Finance (Social Sciences)

This paper examines the spillover effects from the short term interest rates market to equity markets within the Euro area. The empirical study is carried out by estimating an extended Markov Switching GJR in mean model with a Bayesian based Markov Chain Monte Carlo (MCMC) methodology. The result indicates that stock markets in the Euro area display a significant two regimes with distinct characteristics. Within a bear market regime, stock returns have a negative relationship with the volatility, and the volatility process responds asymmetrically to negative shocks of equity returns. The other regime appears to be a bull market regime, within which the returns have a positive relationship with the volatility, and the volatility is lower and more persistent. We find also that there is a significant impact of fluctuations in the short term interest rate on the conditional variance and conditional returns in the EMU countries. Such impact is asymmetrical, and it appears to be stronger in the bear market and when interest rate changes upward.
The monitoring role of the external ownership and discretionary accruals

Field: Economics, Econometrics and Finance (Social Sciences)

Prior studies have focused on the role that the institutional investors play to control managerial behaviours as one of the factors of the external ownership in the developed countries specifically. Nevertheless, scant attention has given to the external ownership role whether the institutional or the foreign investors to maintain the minority shareholder interest especially with the presence of the central agency problem in the emerging markets such as Jordan. Thus, this study argued the monitoring role of the external ownership factors can minimize the managerial opportunistic behaviours through examining the relationship between external ownership factors and earnings management. Earnings management proxies using the performance-adjusted discretionary accruals model (Kothari et al. 2005 model) by applying the cross-sectional method to determine model parameters for each industry in each year. In order to achieve objectives of this research a sample of 798 firm-observation of the Jordanian non-financial firms listed in ASE during the period 2009-2015 were collected. The random-effect GLS regression model is used after following the correct procedures of the panel data analysis to determine the appropriate model as stated by the results of Hausman and LM tests. Hence, the correcting robust standard errors estimates method was used since the data was suffered from the heteroscedasticity problem. The results show that the institutional ownership in Jordan plays a vital role in mitigating the opportunistic behaviours of managers. Likewise, the existence of foreign ownership in firms minimizes the level of earnings management practices. These support the hypotheses that the institutional and foreign investors are able to control the managers of the firm. Also, provide evidence about the similarities between the role of the foreign investors and the role of institutional investors since there is a shortage of the evidence about foreign investors role especially with earnings management.
Pion and $ρ$-meson screening masses at finite chemical potential in two-flavor lattice QCD with Wilson fermion

Field: Physics and Astronomy (Physical Sciences)

We investigate the real and imaginary chemical-potential dependence of pion and $ρ$-meson screening masses in both the confinement and the deconfinement region by using two-flavor lattice QCD. The spatial meson correlators are calculated in the imaginary chemical potential region with lattice QCD simulations. We extract pion and $ρ$-meson screening masses from the correlators. The obtained meson screening masses are extrapolated to the real chemical potential region by assuming some analytic function. In the real chemical potential region, the resulting pion and $ρ$-meson screening masses monotonically increase as real chemical potential becomes large.
Comparative study of Ivan the Terrible and Peter the Great according to Soviet and foreign literature: a survey of literary and historical sources

Field: Arts and Humanities (Social Sciences)

In this critical analysis an attempt has been made to compare two Russian monarchs who both left a deep impression on Russia with the help of foreign and Soviet literature. Because of the fact that the strictly literary material was very limited, I had to turn to historical books of various periods and of different countries. These, however, have proved valuable in exposing me to quite contrasting points of view. Both men lend themselves exceptionally well to comparison because many of their doings are almost identical in purpose and vary only in the methods of execution. Soviet historiography has capitalized on this fact and has used literature as a means of showing Ivan the Terrible as a precursor of Peter the Great. At the same time Soviet literature is making an effort to emulate him for the adulation of the Soviet citizenry. Soviet literature today recognizes him as the great centralizer of Russia and the liquidator of the obstructing aristocracy. This comparison stresses the actions and feelings of Ivan the Terrible and Peter the Great in similar circumstances and situations. The system of treating the two tsars in almost identical situations has been followed right through this thesis in which I examine them in retrospect, i.e. from a distance 400 and 250 years respectively. Despite my efforts to visualize the tsars clearly, to compare, and to evaluate them and their actions "sine ira et studio", I may have fallen short of the desired standard, for it is quite difficult to deal with subjects as controversial as Ivan the Terrible and Peter the Great in a truly objective manner.
@stephanjoubert: Tweeting the gospel aphoristically

Field: Arts and Humanities (Social Sciences)

This contribution focusses on some of the digital theological expressions of Stephan Joubert from an auto-ethnographic angle. Orientating from a practical theology perspective, I have chosen the social media platform Twitter, and more specifically the @stephanjoubert domain, as source to chart some significant tweet expressions for the purpose of describing the character and value of an aphoristic theology. In order to do so, I have used some randomly selected tweets of Stephan Joubert, spanning the period 2020–2021, which express aspects of a relevant contemporary ecclesiology. Against the backdrop of the disastrous impact of the COVID-19 pandemic as well as some important dates on the Christian calendar (Easter and Christmas), I specifically emphasise the significance of the formulation of an aphoristic theology using amongst other markers of simplicity, contextuality and relevance. Contribution: I conclude the reflection with some critical-evaluative remarks on the significance of aphoristic expressions for the development of a meaningful contemporary ecclesiology and theology.
Bolivian Siesta of Science

Field: Environmental Science (Physical Sciences)

RETURN TO ISSUEPREVNewsNEXTBolivian Siesta of ScienceBolivia, a country of high altitudes, cold nights, and extremes in climate, is pioneering territory to the technical man who would help in awakening her to the technological developments which must come if she is to have a place of importance among nationsWAYNE E. WHITEView Author Information Ozark-Malioning Co., Tulsa, Okla.Cite this: Chem. Eng. News 1948, 26, 8, 516Publication Date (Print):February 23, 1948Publication History Published online5 November 2010Published inissue 23 February 1948https://pubs.acs.org/doi/10.1021/cen-v026n008.p516https://doi.org/10.1021/cen-v026n008.p516newsACS PublicationsCopyright © 1948 American Chemical SocietyArticle Views3Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Atmospheric chemistry Get e-Alerts
Patterns of Political Party Activity among U.S. Cities

Field: Social Sciences (Social Sciences)

Urban political parties have enormous potential for affecting local politics, as was demonstrated in the era of the party machine. But we have little systematic knowledge of where and under what circumstances parties remain as viable forces in our cities. Using a measure of local party activity obtained from a survey of elected municipal officials in 186 American cities, this study attempts to identify the conditions that accompany active urban parties. The prevailing level of party activity is found in part to be a function of community education level, region, and city size, but the overriding influence is found to be the presence of legally nonpartisan elections. Further, a connection is found between the level of party activity in a city and voter turnout in city elections.
Numerical Approach to Simulation of Geometry Variation during Sintering of Ceramics Based on the Finite Element Method

Field: Engineering (Physical Sciences)

Sintering is a complex physical and mechanical process, which is one of the most important technological processes in powder metallurgy and ceramic industry. In this paper, the study of free sintering of a ceramic object is carried out using the rheological theory of sintering. Numerical solution of the problem in the three-dimensional case is implemented using the Finite Element Method with the freely distributed FreeFem++ software. Experiments on sintering of aluminium oxide ceramic paste were conducted for several temperature regimes. The validation of the realized model is confirmed by comparing the numerical and experimental data of porosity evolution.
Automatic Registration of Phalanges Regions in CR Images Based on Scale-Invariant Salient Region Features

Field: Computer Science (Physical Sciences)

As two common orthopedic diseases, there are rheumatoid arthritis (RA) and osteoporosis. And early detection and early treatment are important for these diseases. However, some problem such as mass screening on data sets, mis-diagnosis are still remained in visual screening. In order to solve these problems and reduce the burden to physicians, needs of an automatic diagnosis system capable of performing quantitative analysis is anticipated. In this paper, we carry out the development of a registration method of phalanges regions from CR images of the hand to detect temporal changes of phalanges regions by alignment between previous image and current one. The proposed method is carried out registration of phalanges regions using salient region features (SRF) in image. Specifically, SRF are detected from phalanges regions. Then, rigid registration technique is performed using deformation amount based on SRF. We applied our method on 84 pairs of CR temporal images of phalanges regions.
Metabolome

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Recommendations are given concerning the terminology of methods of bioanalytical chemistry. With respect to dynamic development particularly in the analysis and investigation of biomacromolecules, terms related to bioanalytical samples, enzymatic methods, immunoanalytical methods, methods used in genomics and nucleic acid analysis, proteomics, metabolomics, glycomics, lipidomics, and biomolecules interaction studies are introduced.
Gray Correlative Degree Analysis of Main Quantitative Traits of Pepper

Field: Agricultural and Biological Sciences (Life Sciences)

The effect of main quantitative traits on yield of pepper and the correlation of fruit's traits were studied by gray correlative degree analysis.The results showed that the correlative degree to the yield per plant ranked from weight of per fruit,fruit width,plant height,number of fruit,pulp thickness,fruit length,number of ventricles,flower period,plant width,fruit setting period,and floral period.The weight of per plant,fruit width,plant height and number of fruit were closely related to yield.Among them,the effect of weight of per plant,fruit width on fruit shape were the most important traits.
The study of temperature and UV light effect in anthocyanin extract from dragon fruit (Hylocereus costaricensis) rind using UV-Visible spectrophotometer

Field: Agricultural and Biological Sciences (Life Sciences)

This study aimed to determine the total of anthocyanin content in ethanol extract from super red dragon fruit rind. The extraction was affected by temperature and light conditions. The determination of anthocyanin's total content was performed with a variation of pH and analyzed by UV-Visible spectrophotometer. The results showed that the average contained total anthocyanins obtained at room temperature, 40 and 60 °C were 4.6757, 5.6108, 21.9757 mg/L, respectively. In higher temperatures, it was observed the more anthocyanin extracted. The concentration of anthocyanin extract without UV light was 2.5716 mg/L, it was less than UV light assisted extract, i.e. 5.3770 mg / L.
Historians, historiography and archaeologically imperceptible change

Field: Arts and Humanities (Social Sciences)

Archaeology, which does not understand short times and specific events, offers us no detectable changes that can be ascribed to the events that happened around 1212. Al-Andalus continued its internal development regardless of what happened in Las Navas de Tolosa and only with the Castilian conquest was the process interrupted. In the lands of the south-eastern Iberian Peninsula, we should speak – from an archaeological perspective – of maximum intensity in the slow construction of a violent path of no return, rather than of a major turning point: the conquest and the end of al-Andalus, the imposition of one society on another and the creation of a new world.