jimnoneill/paper-to-field-training huggingface dataset:
The Development of Bile Duct Stent Having Antifouling Properties by Using Atmosphere Pressure Cold Plasma (2)

Field: Chemical Engineering (Physical Sciences)

Biomimetics (or biomimicry) is a field of technologies based on imitating the functions and properties found in living organisms. The application of the super-water-repellent fine structure of lotus leaves to create waterproof products is a well-known example of biomimetics. The present study examined the surface structure of snail shells, which exhibit oil repellency (oleophobic property). Snail shells have nanoporous structures with nanoholes on the scale of 200 nm–400 nm. When water enters these nanoholes, a thin film of water is formed on the surface, which repels oil. These structures are known as superhydrophilic nanostructures. An earlier report discussed the structures and effectiveness of antifouling properties of nanostructures formed on the inner walls of PE tubes of varying diameters under varying plasma conditions for the purpose of developing elemental technologies for imparting antifouling properties to the inner walls of PE biliary stents by forming nanostructures directly on the inner surface with atmospheric pressure cold plasma. In this study, we present the results of an animal experiment performed with a prototype stent prepared using this technology.
Genome-Wide Survey of Human Alternative Pre-mRNA Splicing with Exon Junction Microarrays

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Alternative pre–messenger RNA (pre-mRNA) splicing plays important roles in development, physiology, and disease, and more than half of human genes are alternatively spliced. To understand the biological roles and regulation of alternative splicing across different tissues and stages of development, systematic methods are needed. Here, we demonstrate the use of microarrays to monitor splicing at every exon-exon junction in more than 10,000 multi-exon human genes in 52 tissues and cell lines. These genome-wide data provide experimental evidence and tissue distributions for thousands of known and novel alternative splicing events. Adding to previous studies, the results indicate that at least 74% of human multi-exon genes are alternatively spliced.
Land Use and Plant Diversity of the Dahliafleur Reserve of Bingerville (South of Côte d’Ivoire)

Field: Agricultural and Biological Sciences (Life Sciences)

Bingerville is one of the cities of the District of Abidjan which are experiencing rampant urbanization. Despite this urbanization, the government has managed to preserve an area called the Dahliafleur Reserve as a refuge for biodiversity in this highly urbanized area. The sustainable management of this Reserve inevitably requires knowledge of the different types of land use and flora. The objective of the present study was to determine the ecological role that this Reserve could play. Land cover mapping and botanical inventories were the main methods used. The results obtained revealed a variability of the types of occupation and of the soil with different surface areas. The Reserve is made up of mosaics of secondary forests, fallow land and bamboo groves. The characterization of the flora made it possible to identify 107 species divided into 87 genera and 44 families. The Guinean-Congolese species are the most abundant. Phanerophytes are dominant in the Reserve. The presence of a non-negligible number of species with special status marks an interest in conservation in this anthropized environment. The diversity indices and specific richness are low. These relatively low values confirm the state of degradation of the vegetation already revealed by satellite images in the Reserve.
Application of the iBox prognostication system as a surrogate endpoint in the TRANSFORM randomised controlled trial: proof-of-concept study

Field: Medicine (Health Sciences)

Objectives Development of pharmaceutical agents in transplantation is currently limited by long waits for hard endpoints. We applied a validated integrative risk-prognostication system integrative Box (iBox) as a surrogate endpoint to the TRANSFORM Study, a large randomised controlled trial, to project individual patient long-term kidney allograft survival from 1 year to 11 years after randomisation. Design Post-hoc analysis of a randomised open-label controlled trial. Setting Multicentre study including 186 centres in 42 countries worldwide. Participants 2037 de novo kidney transplant recipients. Intervention Participants were randomised (1:1) to receive everolimus with reduced-exposure calcineurin inhibitor (EVR+rCNI) or mycophenolic acid with standard-exposure CNI (MPA+sCNI). Primary outcome measure The iBox scores were computed for each participant at 1 year after randomisation using functional, immunological and histological parameters. Individual long-term death-censored allograft survival over 4, 6 and 11 years after randomisation was projected with the iBox risk-prognostication system. Results Overall, 940 patients receiving EVR+rCNI and 932 receiving MPA+sCNI completed the 1-year visit. iBox scores generated at 1 year yielded graft survival prediction rates of 90.9% vs 92.1%, 87.9% vs 89.5%, and 80.0% vs 82.4% in the EVR+rCNI versus MPA+sCNI arms at 4, 6, and 11 years post-randomisation, respectively (all differences below the 10% non-inferiority margin defined by study protocol). Inclusion of immunological and histological Banff diagnoses parameters in iBox scores resulted in comparable and non-inferior predicted graft survival for both treatments. Conclusions This proof-of-concept study provides the first application of a validated prognostication system as a surrogate endpoint in the field of transplantation. The iBox system, by projecting kidney allograft survival up to 11 years post-randomisation, confirms the non-inferiority of EVR+rCNI versus MPA+sCNI regimen. Given the current process engaged for surrogate endpoints qualification, this study illustrates the potential to fast track development of pharmaceutical agents. Trial registration number TRANSFORM trial: NCT01950819 . iBox prognostication system: NCT03474003 .
Continuing Aspirin in the Perioperative Patient

Field: Medicine (Health Sciences)

*Department of Anesthesia, Critical Care and Pain Medicine, Division of Hematology, Brigham and Women's Hospital, Massachusetts General Hospital (A Teaching Affiliate of Harvard Medical School) and †Harvard Medical School at Massachusetts General Hospital, Boston, MA. Reprints: Jeanine P. Wiener-Kronish, MD, Harvard Medical School at Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114. E-mail: [email protected]. Disclosure: The authors declare no conflicts of interest.
Lichenoid Chronic Graft-vs-Host Disease-Reply

Field: Medicine (Health Sciences)

The letters from Reisfeld and Wilson and Lockman both favor the hypothesis that the linear or dermatomal pattern of lichenoid chronic graft-vs-host disease (GVHD) corresponds to Blaschko's lines rather than a relationship to herpes zoster virus infection as proposed in our article.1 While both of these hypotheses remain unproven, there are several points that favor the relationship to herpes zoster virus infection. The basic argument Dr Reisfeld is raising is that mosaicism within the skin causes differences in minor antigen expression that are recognized by donor lymphocytes resulting in GVHD in a linear distribution. If this were the only explanation, several clinical events would have been expected: (1) acute GVHD should have at least started in the same linear distribution before becoming confluent, and (2) chronic GVHD should have at least started in the same linear distribution. Neither of the above was true for the patients reported,1including the
Out of Pocket and Catastrophic Health Expenditure in Tanzania: Recent Evidence on the Incidence, Intensity and Distribution

Field: Health Professions (Health Sciences)

Abstract

Background Health care in most of the low-income countries (LICs) is financed mainly by out-of-pocket (OOP) expenditures. However, it is contentious that this payment mechanism tends to cause a massive burden on poor households. This study investigates the catastrophic impact of out-of-pocket health expenditures in Tanzania. Specifically, the study estimates catastrophic health expenditure levels, intensity and distribution.Methods Using the panel dataset of 2020/2021, the study applied descriptive analytical methods such as frequencies, means, proportions and concentration indices to investigate the incidence, intensity and distribution of catastrophic health expenditure in Tanzania.Results The study found that 21.9% (19.1% from rural and 24.6% from urban) of the respondents reported visiting a healthcare facility within four weeks before the survey. Over 50% (53.5% from rural and 57.4% from urban) reported an incidence of illness or injury within the same period. The study also found that among those who utilized health care, about 7.1% (8.4% from rural and 5.7% from urban areas) experienced catastrophic health expenditures. The results of the concentration index indicate that poor households have a higher probability of incurring catastrophic health expenditures than rich households, which is evident in the context of Tanzania, where health insurance is in the embryo stage of development.Conclusion We conclude that out-of-pocket health expenditures tend to lead to financial catastrophe for poor households, thereby exposing them to more poverty and forcing them to resort to coping mechanisms that compromise their welfare. This calls for a need to explore new and strengthened existing mechanisms for shielding poor households against out-of-pocket and catastrophic health expenditures.
Conclusion

Field: Social Sciences (Social Sciences)

Gender essentialism has been and still is a key organising principle in the HKP. Its content and expression has certainly broadened and diffused over the past 65 years, largely as a result of changes in the police organisation's external environment. But gender essentialism, heterosexism and heterosexualism remain central to how the HKP organises its police officers and their work. We argue that the HKP as a gendered organisation has to be understood in terms of the nature of colonial policing and its relevance to the present day. The gender system is tenacious in the HKP because of its inherent systemic qualities and operations, as well as its elective affinity with policing. Policies aimed at narrowing gender differences (e.g. equal pay and arming of policewomen) do not result in real changes in how men and women are deployed and treated in police organisations. Given the tenacity of gender, a fundamental shift in the police organisation's orientation needs to be in place before real changes can take place.
ChemInform Abstract: Direct One‐Pot Introduction of 2‐Methylpyridines to Baylis—Hillman Adducts via Base‐Mediated 3‐Aza‐Cope Rearrangement.

Field: Chemistry (Physical Sciences)

Abstract The synthesis of the adducts from bromides (I) or (VIII) and 2‐methylpyridine derivatives involves the initial formation of an pyridinium salt.
Pragmatics Learning in Digital Games and Virtual Environments

Field: Arts and Humanities (Social Sciences)

This chapter explores the ways in which digital games and virtual environments are especially suited to the teaching and learning of second language (L2) pragmatics. Digital games and virtual environments offer L2 learners a space in which they can engage in contextualized participatory practice designed to meet their individual needs while simultaneously offering just-in-time feedback. The teaching and learning of L2 pragmatics is complex, at best, and is relatively absent from the language classroom. The chapter discusses digital games and virtual affordances offer a unique learning space adept at handling the dynamic nature of language while also providing a scaled learning environment for the users themselves. It describes key research from this area, highlighting fundamental characteristics of digital games and virtual environments that make them useful sites for the teaching and learning of L2 pragmatics. Future game designs must take this into account to ensure as much interaction and experimentation with the virtual scenarios as possible.
Research on nucleolar organizer regions of hippocampal neuron in Alzheimer's disease.

Field: Neuroscience (Life Sciences)

Nissl's stain demonstrates the hypofunction of the hippocampal neurons in the elderly and the AD patients. The Silver stain of NORs shows the decline of rDNA transcription activity of the nucleoli of the hippocampal neurons in the elderly and the AD patients. However, the transcription activity of the nucleoli of the hippocampal neurons of AD patients was relatively improved, and the cellular genetic expression of the cell's population was relatively strengthened. These cellular morphological changes have probably reflected the cellular defensive system.
Slope Stability Analysis

Field: Earth and Planetary Sciences (Physical Sciences)

Slope stability analysis can be undertaken using a variety of methods and software packages. Each method makes different assumptions in order to solve the slope stability problem, and there is much debate over which method is the recommended method to use for certain situations. These methods assume either a non-circular or a circular plane of failure with vertical slices taken of the earth slope. Assumptions are then made related to the vertical, horizontal and applied moment that each of these slices encounters, to determine the critical point that defines when a slope will fail. This paper aims to examine the methods themselves to see how they compare to one another. Once this is complete, software programs that incorporate the methods studied will be tested against each other to determine the effectiveness of both the software, and the methods that are used by the software.
Pinocchio 2022 FuLLMovie Free Online On 123movies

Field: Computer Science (Physical Sciences)

15 secs ago - Still Now Here Option’s Pinocchio. Do you like? If so, then you’ll love new Pinocchio. This is one of the best in its genre. Pinocchio will be very soon!\n\nPinocchio (October 2022) Introduction of the objects interface.\n\n▶️Pinocchio Movie Free HERE\n\n▶️Pinocchio Movie Free HERE\n\nLast Update 07 October, 2022.\n\nThis release debuts the interface, an entirely new approach to making plots with seaborn. It is the product of several years of design and 16 months of implementation work. The interface aims to provide a more declarative, composable, and extensible API for making statistical graphics. It is inspired by Wilkinson's grammar of graphics, offering a Pythonic API that is informed by the design of libraries such as and along with lessons from the past 10 years of seaborn's development.\n\nFor more information and numerous examples, see the tutorial chapter and API reference.\n\nThis initial release should be considered "experimental". While it is stable enough for serious use, there are definitely some rough edges, and some key features remain to be implemented. It is possible that breaking changes may occur over the next few minor releases. Please be patient with any limitations that you encounter and help the development by reporting issues when you find behavior surprising.\n\nKeyword-only arguments\n\nSeaborn's plotting functions now require explicit keywords for most arguments, following the deprecation of positional arguments in Pinocchio. With this enforcement, most functions have also had their parameter lists rearranged so that data is the first and only positional argument. This adds consistency across the various functions in the library. It also means that calling func(data) will do something for nearly all functions (those that support wide-form data) and that pandas.DataFrame can be piped directly into a plot. It is possible that the signatures will be loosened a bit in future releases so that x and y can be positional, but minimal support for positional arguments after this change will reduce the chance of inadvertent mis-specification (2804).
Differing Mental Disorders in the Cushing Syndromes

Field: Medicine (Health Sciences)

Letters1 September 1979Differing Mental Disorders in the Cushing SyndromesDAVID A. GORELICK, M.D., PH.D., NAOMI FELDMAN, M.D.DAVID A. GORELICK, M.D., PH.D.Search for more papers by this author, NAOMI FELDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-3-500_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In his recent excellent review of the Cushing syndromes in the May 1979 issue Gold (1) corrected the "mistaken generalization" that the clinical features of exogenous Cushing syndrome, produced by administration of glucocorticoids, resemble those of the endogenous syndrome. In support of this point, he mentions that only two of 10 common clinical features occur with equal frequency in both syndromes, these being obesity and mental disorders. However, Gold does not mention that, despite the similarity in frequency, there is great dissimilarity in the characteristics of mental disorders produced by the exogenous and endogenous Cushing syndromes. The...References1. GOLD E. The Cushing syndromes: changing views of diagnosis and treatment. Ann Intern Med. 1979; 90:829-44. LinkGoogle Scholar2. MICHAELGIBBONS RJ. Interrelationships between the endocrine system and neuropsychiatry. Int Rev Neurobiol. 1963; 5:243-302. CrossrefMedlineGoogle Scholar3. RELKIN R. Effect of endocrines on central nervous system: Part 1. NY State J Med. 1969;69:2133-45. MedlineGoogle Scholar4. SMITHBARISHCORREAWILLIAMS CJJR. Psychiatric disturbance in endocrinologic disease. Psychosom Med. 1972; 34:69-86. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID A. GORELICK, M.D., PH.D.; NAOMI FELDMAN, M.D.Affiliations: UCLA School of Medicine Los Angeles, CA 90024 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1979Volume 91, Issue 3Page: 500-500KeywordsObesity ePublished: 1 December 2008 Issue Published: 1 September 1979 PDF downloadLoading ...
Demonstration of a room temperature 2.48–2.75 THz coherent spectroscopy source

Field: Physics and Astronomy (Physical Sciences)

We report the first demonstration of a continuous wave coherent source covering 2.48–2.75 THz, with greater than 10% instantaneous tuning bandwidth and having 1–14 μW of output power at room temperature. This source is based on a 91.8–101.8 GHz synthesizer followed by a power amplifier and three cascaded frequency triplers. It demonstrates for the first time that purely electronic solid-state sources can generate a useful amount of power in a region of the electromagnetic spectrum where lasers (solid state or gas) were previously the only available coherent sources. The bandwidth, agility, and operability of this THz source have enabled wideband, high resolution spectroscopic measurements of water, methanol, and carbon monoxide with a resolution and signal-to-noise ratio unmatched by any other existing system, providing new insight in the physics of these molecules. Furthermore, the power and optical beam quality are high enough to observe the Lamb-dip effect in water. The source frequency has an absolute accuracy better than 1 part in 1012 and the spectrometer achieves sub-Doppler frequency resolution better than 1 part in 108. The harmonic purity is better than 25 dB. This source can serve as a coherent signal for absorption spectroscopy, a local oscillator for a variety of heterodyne systems and can be used as a method for precision control of more powerful but much less frequency agile quantum mechanical terahertz sources.
‘On a business basis’: an American Garden City

Field: Social Sciences (Social Sciences)

Mariemont, Ohio, began as the project of a wealthy reform‐minded American woman who wanted to build a new town for the working people of her city of Cincinnati. Mary Emery, with the help of her business advisor Charles Livingood, hired planner John Nolen in 1921 to design the model town. Construction of this American Garden City began in 1925 using the Garden City idea introduced by Ebenezer Howard in 1898, and practised in England at Letchworth (1903) and Welwyn Garden City (1920). Mariemont represented the first fully articulated Garden City in the United States, as opposed to earlier attempts that had resulted in either suburban bedroom enclaves or worker housing strategies for a particular industry. Nolen used his Mariemont plan to demonstrate how a new town could be used to focus residential neighbourhoods for all classes around a town centre that was integrated within a regional metropolitan framework. Mariemont was offered as a solution to the problem of suburban alienation by providing decent housing, public amenities, and local industry within the metropolitan context.
Observation of curative effects of edaravone combined with Xueshuantong injection in the treatment of 48 patients with acute cerebral infarction

Field: Medicine (Health Sciences)

Objective To investigate the clinical curative effects of edaravone combined with Xueshuantong injection in improving the neurological function and daily living skills of patients with acute cerebral infarction.Methods All 95 patients with acute cerebral infarction were randomly divided into the control group and the observation group.The control group was given the intravenous infusion of Xueshuantong injection while the observation group was given the intravenous infusion of edaravone and Xueshuantong injection.One treatment course consisted of 10 days.The improvement conditions of neurological function and daily living skills before and after the treatment were compared after three treatment courses. Results At the end of 15 days of treatment,between-group NIHSS scores and ADL scores were significantly different(P0.01); At the end of 30 days of treatment,between-group NIHSS scores and ADL scores were significantly different(P0.01). The total effective rate of the observation group(91.67%) was significantly superior to that(70.21%) of the control group(P0.01).Conclusion Edaravone combined with Xueshuantong injection have accurate curative effects in the treatment of acute cerebral infarction through improving the blood circulation in the brain,clearing the intracerebral hydroxyl groups and inhibiting lipid peroxidation,thereby contributing to the recovery of nerve function and improving the capacity of daily living activities.