jimnoneill/paper-to-field-training huggingface dataset:
[Paleopathologic findings of premature coronal suture closure].

Field: Medicine (Health Sciences)

The work describes paleopathologic finding of brachycephaly deformation in 4 adult skulls, caused by premature coronal suture closure. Skulls come from the 35 pieces collection of craniostenoses, found in osteologic collection of 745 skulls from Broumov Ossuary. They were examined by cranioscopy, craniometry, x-ray and CT methods. Presence of brachycephaly in Broumov collection of skulls ant their percentage in the collection of craniosynostoses is discussed in the context with recent clinical data.
Social Law 4.0: Update

Field: Social Sciences (Social Sciences)

Platform work continues to grow. This is also true in European countries, where it poses challenges for access to social security systems and their financing. The book “Social 4.0”, published in 2021, examines these challenges and presents innovative solutions in different countries and in European cooperation. Four years on, in which the practical difficulties have become even more apparent, the “Update” asks whether the solutions have worked and what further developments have taken place. Short reports from Belgium, Italy, the United Kingdom, France, Sweden and the Netherlands answer these questions. They are complemented by insights into EU social and tax law. In a detailed concluding chapter, the findings of both books are systematically summarised, evaluated comparatively and guidelines for future legislative responses are presented.
Non‐invasive metastasis prognosis from plasma metabolites in stage II colorectal cancer patients: The DACHS study

Field: Medicine (Health Sciences)

Metastasis is the main cause of death from colorectal cancer (CRC). About 20% of stage II CRC patients develop metastasis during the course of disease. We performed metabolic profiling of plasma samples from non‐metastasized and metachronously metastasized stage II CRC patients to assess the potential of plasma metabolites to serve as biomarkers for stratification of stage II CRC patients according to metastasis risk. We compared the metabolic profiles of plasma samples prospectively obtained prior to metastasis formation from non‐metastasized vs . metachronously metastasized stage II CRC patients of the German population‐based case–control multicenter DACHS study retrospectively. Plasma samples were analyzed from stage II CRC patients for whom follow‐up data including the information on metachronous metastasis were available. To identify metabolites distinguishing non‐metastasized from metachronously metastasized stage II CRC patients robust supervised classifications using decision trees and support vector machines were performed and verified by 10‐fold cross‐validation, by nested cross‐validation and by traditional validation using training and test sets. We found that metabolic profiles distinguish non‐metastasized from metachronously metastasized stage II CRC patients. Classification models from decision trees and support vector machines with 10‐fold cross‐validation gave average accuracy of 0.75 (sensitivity 0.79, specificity 0.7) and 0.82 (sensitivity 0.85, specificity 0.77), respectively, correctly predicting metachronous metastasis in stage II CRC patients. Taken together, plasma metabolic profiles distinguished non‐metastasized and metachronously metastasized stage II CRC patients. The classification models consisting of few metabolites stratify non‐invasively stage II CRC patients according to their risk for metachronous metastasis.
Fig.S1 from Primary Analysis and 4-Year Follow-Up of the Phase III NIBIT-M2 Trial in Melanoma Patients With Brain Metastases

Field: Medicine (Health Sciences)

<p>Study design and treatment schedule. Patients in either the ipilimumab plus fotemustine arm or the ipilimumab plus nivolumab arm could continue maintenance treatment until disease progression, excessive toxicity, or patient refusal</p>
four promising titles in the Dow "library" of special chemicals

Field: Chemistry (Physical Sciences)

RETURN TO ISSUEPREVAdvertisementfour promising titles in the Dow "library" of special chemicalsCite this: Chem. Eng. News 1945, 23, 15, obcPublication Date (Print):August 10, 1945Publication History Published online4 November 2010Published inissue 10 August 1945https://doi.org/10.1021/cen-v023n015.obcCopyright © 1945 AMERICAN CHEMICAL SOCIETYArticle Views58Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (42 KB) Get e-Alerts
The Effect of Consumer Ethnocentrism, Brand Image, and Perceived Quality,on Purchase Decisions With Purchase Intention as Intervening Variable (Study of Eiger Consumers in Tasikmalaya)

Field: Business, Management and Accounting (Social Sciences)

The purpose of this research is to know and analyze the effect of consumer ethnocentrism, brand image, and perceivedquality of Eiger outdoor equipment product to consumer purchase decision, and to test purchase intention as intervening variable between consumer ethnocentrism ,brand image, and perceivedquality effect the purchase decision. The sample in this study there are 180 respondents who are users of Eiger products in Tasikmalaya region. Convenience sampling method is used in the determination of this research sample. Data were analyzed using Structural Equational Modeling (SEM) with SPSS and AMOS statistical software. The results of this study show that. Consumer ethnocentrism has a positive but no significant effect on purchase decisions. Brand image has a positive but no significant effect on purchase decisions. Perceived quality have a positive effect on purchase decisions. Purchases intention have a positive effect on purchase decisions. Consumer ethnocentrism positively effects purchase decisions with purchase intention as intervening variable. Brand image positively effects purchase decisions with purchase intention as intervening variable. Perceived quality positively effect purchase decisions with purchase intention as intervening variable.
Intertextual Representation Of The Orang Asli In The Malaysian Online News Media: A Critical Discourse Analysis

Field: Social Sciences (Social Sciences)

In media discourse, intertextuality is an important aspect which is concerned with how voices are represented and weaved into news articles.The study sets out to explore how the Orang Asli are intertextually represented in the selected Malaysian news media, namely The Star (mainstream news media) and Malaysiakini (alternative news media).The corpus of this study comprises 24 online news articles from The Star (n=12) and Malaysiakini (n=12), respectively.The analysis is grounded on Fairclough's (1995b) Three-Dimensional Critical Discourse Analysis (CDA) Framework focusing on the intertextual aspect, notably the news articles' discourse representation.The results showed that the voices of the authorities were represented more frequently in The Star as compared to the Orang Asli, whereas both voices were represented fairly by Malaysiakini.Furthermore, the quotation patterns revealed that the authorities were directly quoted more frequently than the Orang Asli, especially in The Star.Although Malaysiakini quoted the Orang Asli, the quotations continue to perpetuate an inferior and stereotypical imagery of the community which revolves around vulnerable and dependent narratives.In general, the intertextual analysis reveals that the authorities' voices continue to predominate the mainstream media in reinforcing existing perceptions of the Orang Asli community as well as speaking on behalf of the community, which in turn suppresses the Orang Asli's voices.
Potential for cost savings with pharmacy intern‐led inpatient clinical services

Field: Health Professions (Health Sciences)

Abstract Introduction Paid clinical pharmacy internships serve important roles for pharmacy students, health systems, and pharmacy departments. The Denver Health Medical Center Pharmacy Internship program incorporates progressive clinical responsibilities for advancing pharmacy students. Cost savings associated with clinical pharmacy interns have not been well studied. Objectives This study describes the potential cost savings of intern‐led clinical services and provides a rationale for medical centers to expand clinical roles for pharmacy interns. Methods This single center retrospective review of pharmacy intern clinical activities evaluated pharmacy intern‐initiated interventions between January 1, 2017 and February 28, 2018. After completing 2 years of pharmacy operations focused training, third year pharmacy interns were trained to provide numerous clinical interventions under the supervision of staff pharmacists. Interventions and their associated cost savings were documented using standardized templates and predetermined default settings available in the electronic medical record after standard procedures used by clinical staff pharmacists. Labor costs were determined form payroll records for paid interns during the study period. Net cost‐benefits were determined by subtracting aggregated cost savings of clinical interventions from labor costs for employed interns during the same time period. Results Five interns documented 336 interventions totaling $94 681 (mean $281.79) in associated cost savings. Sixty‐six percent of interventions were identified as high clinical significance by the department. The labor costs for the five interns totaled $7332.40 equating to an hourly cost savings of $193.00 for each hour of paid intern time. The average time to complete an intervention was 20 minutes. The most frequently documented interventions were providing anticoagulation therapeutic drug monitoring (67.3%) and antimicrobial stewardship interventions (21.4%). Conclusions During the study period, clinical interns generated a greater cost savings for the institution than the labor cost associated with their paid time. This study supports the expanded role of pharmacy interns to include clinical activities.
ANALISIS FUNGSI KAWASAN HUTAN LINDUNG, HUTAN PRODUKSI TERBATAS, DAN HUTAN PRODUKSI TETAP DI KABUPATEN KOLAKA TIMUR

Field: Environmental Science (Physical Sciences)

This study aims to analyze the functions of protected forest areas, limited production forests and permanent production forests in East Kolaka Regency. This type of research is descriptive quantitative and area survey with the main study being the description of maps of physical factors and non-physical reasons. The research also examines the suitability of the map with the actual conditions in the field. Physical Data Collection Method using ArcGIS 10.4.1 software base map from BAPPEKAB East Kolaka Regency and BMKG. The Data of non-physical factors is the form of data related to inappropriate land use were collected through interviews. Descriptive analysis is presented in the form of: overlay with the scoring equipped, tables of areas and percentages. The criteria for designating a protected forest are fully explained in the Decree of the Minister of Agriculture Number 2837/Kpts/Um/11/1980. The results of the study show that the potential function of the area in East Kolaka Regency consists of Limited Production Forests and Production Forests. Most of the Limited Production Forests are in Ueesi District with 159,709.465 hectares or 40.72%. Most production forests are in Ueesi District with 20,937.437 hectares or 5.33%. The Limited Production Forest Area experienced a difference of 3,214.329 being settlements, dry land agriculture, paddy fields, and transmigration. Production Forest Areas experienced a difference of 64,042.12 into settlements, dry land agriculture, rice fields, and transmigration.
The Impact of Green Finance on Renewable Energy Development in India's Tourism Industry

Field: Economics, Econometrics and Finance (Social Sciences)

This study utilizes the Autoregressive Distributed Lag (ARDL) methodology to evaluate the influence of green financing on sustainable energy practices in India's tourism industry from 2000 to 2022. The findings suggest that the issue of green bonds has a substantial and favorable impact on the long-term environmental sustainability of the business, albeit the immediate consequences are negligible. Furthermore, the consumer price index has a negative impact on environmental sustainability, both in the short and long term. To promote sustainable practices, suggested policy solutions encompass increased regulatory supervision, transparent distribution of market data, implementation of environmentally conscious fiscal policies, and the use of eco-friendly construction technology. The tourist sector in India may greatly benefit by aggressively promoting sustainable globalization, encouraging innovation, adaptation, and stabilization (IAS), and placing a major focus on eco-tourism regionalism. This study provides useful insights for policymakers aiming to improve environmental sustainability in the tourism industry. The report highlights the significance of green financing and suggests specific policy measures to guide the adoption of sustainable practices in India's tourist sector.
Toxocarose : une maladie négligée en Suisse ? [Toxocariasis, a neglected disease in Switzerland ?]

Field: Medicine (Health Sciences)

Toxocariasis is a zoonotic disease that occurs when humans are infected by the parasites Toxocara canis or Toxocara cati. Toxocariasis is highly prevalent in tropical areas, but can also be found in industrialized countries, particularly in rural areas. Clinical presentation can range from asymptomatic infection to more severe disease. Diagnosis of toxocariasis is based on suggestive clinical findings, eosinophilia and a positive serological testing. Albendazole represents the first-line treatment, associated with corticosteroids in case of severe disease. Here we describe three clinical cases of toxocariasis in order to illustrate the clinical presentation, diagnosis and treatment of this unrecognized disease.
The PKCalpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Protein kinase C (PKC) is a key regulator of cell proliferation, differentiation, and apoptosis and is one of the drug targets of anticancer therapy. Recently, a single point mutation (D294G) in PKCa has been found in pituitary and thyroid tumors with more invasive phenotype. Although the PKCa-D294G mutant is implicated in the progression of endocrine tumors, no apparent biochemical/cell biological abnormalities underlying tumorigenesis with this mutant have been found. We report here that the PKCa-D294G mutant is unable to bind to cellular membranes tightly despite the fact that it translocates to the membrane as efficiently as the wild-type PKCa upon treatment of phorbol ester. The impaired membrane binding is associated with this mutant&#039;s inability to transduce several antitumorigenic signals as it fails to mediate phorbol ester-stimulated translocation of myristoylated alanine-rich protein kinase C substrate (MARCKS), to activate mitogen-activated protein kinase and to augment melatonin-stimulated neurite outgrowth. Thus, the PKCa-D294G is a loss-of-function mutation. We propose that the wild-type PKCa may play important antitumorigenic roles in the progression of endocrine tumors. Therefore, developing selective activators instead of inhibitors of PKCa might provide effective pharmacological interventions for the treatment of certain endocrine tumors.
Peer Review #2 of "LIMK1/2 inhibitor LIMKi 3 suppresses porcine oocyte maturation (v0.3)"

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

LIMKi 3 is a specific selective LIMK inhibitor against LIMK1 and LIMK2, while LIMK1 and LIMK2 are the main regulators of actin cytoskeleton to participate in many cell activities.However, the effect of LIMKi 3 in porcine oocyte meiosis is still unclear.The present study was designed to investigate the effects of LIMKi 3 and potential regulatory role of LIMK1/2 on porcine oocyte meiotic maturation.Immunofluorescent staining of p-LIMK1/2 antibody showed that LIMK1/2 was localized mainly to the cortex of porcine oocyte, which colocalized with actin.After LIMKi 3 treatment, the diffusion of COCs became weak and the rate of polar body extrusion was decreased.This could be rescued by moving oocytes to fresh medium.After prolonging the culture time of oocytes, the maturation rate of porcine oocyte increased in LIMKi 3 groups, indicating that LIMKi 3 may suppress the cell cycle during porcine oocyte maturation.We also found that after LIMKi 3 treatment actin distribution was significantly disturbed at porcine oocyte membranes and cytoplasm, indicating the conserved roles of LIMK1/2 on actin dynamics.Next we examined the meiotic spindle positioning in porcine oocyte, and the results showed that a majority of spindles were not attached to the cortex of porcine oocyte, indicating that LIMKi 3 may affect actin-mediated spindle positioning.Taken together, these results showed that LIMK1/2 inhibitor LIMKi 3 had a repressive role on porcine oocyte meiotic maturation.
Confessions in the Criminal Process

Field: Social Sciences (Social Sciences)

Abstract This article undertakes a theoretical exploration of the roles that confessions can play in the criminal process and of the importance that is placed on their voluntariness. It draws on contemporary and historical sources, as well as materials from different legal systems and traditions. Three possible perspectives on the topic are identified: the moral, the epistemic and the political. Adopting each of these perspectives in turn, I set out three distinct dimensions of confessions in the criminal process. In my account of each dimension, voluntariness is construed in the light of a particular understanding of confessions that is conceptually tied to a particular understanding of the criminal process. The conclusion remarks on the interplay of the three dimensions.
Patterns of resistance to 2‐deoxy‐D‐glucose in pig kidney cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Variants resistant to 2‐deoxy‐D‐glucose have been isolated from a clonal line of pig kidney cells by serial cultivation in the presence of inhibitor. Hexokinase activity may be affected directly in this system, since the oxidation of glucose to 6‐phosphogluconate by extracts from sensitive and resistant cells is blocked by the addition of 2‐deoxy‐glucose to the reaction mixture. This blockage was removed by the addition of glucose‐6‐phosphate to the system, but not by ATP. Resistant cells were found to accumulate significantly less 2‐deoxyglucose‐6‐phosphate than sensitive cells. The rate of phosphorylation of 2‐deoxyglucose, however, was higher in extracts from the resistant line. Alkaline phosphatase does not account for the reduced level of 2‐deoxyglucose‐6‐phosphate since this enzyme is not detectable in sensitive or resistant pig kidney cells. Increased acid phosphatase activity was observed in resistant cells, but extracts with high acid phosphatase activity proved incapable of hydrolyzing either 2‐deoxyglucose‐6‐phosphate or glucose‐6‐phosphate. In comparative growth studies, cells resistant to 2‐deoxyglucose proliferated more extensively than sensitive cells in a low glucose nutrient. They removed glucose more effectively from this medium, and were less stimulated by the addition of intermediates from the tricarboxylic acid cycle. The evidence suggests that resistance to 2‐deoxyglucose in the cells under study may be based on the ability of the resistant cells to proliferate at concentrations of glucose too low to support the growth of sensitive cells.
Mycosphaerella marksii . [Descriptions of Fungi and Bacteria].

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract A description is provided for Mycosphaerella marksii . Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: Eucalyptus botryoides, E. fraxinoides, E. globulus, E. grandis, E. nitens, E. quadrangulata, E. saligna . DISEASE: Leaf spot of Eucalyptus . GEOGRAPHICAL DISTRIBUTION: Australia. TRANSMISSION: Spores are wind-borne.
[Current problems of surgical tactics and technics in gastric neoplasms].

Field: Medicine (Health Sciences)

The authors have investigated 413 cases with gastric neoplasms that have been operated over a period of 20 years. It was noted that the operability index, and the resectability index have not improved in time. Only in 39,3 percent of the patients subtotal gastrectomy was possible, while 12,1 percent underwent total gastrectomy, 6,2 percent palliative interventions, and the remaining 42,4 percent had only exploratory laparotomy. The authors conclude that the principle of exeresis within the limits of oncological security applies only to limited tumours, without extraparietal extension. The maintenance of a gastric sector, either in the para-cardial or in the juxta-pyloric area, depending on the location of the tumour, is almost always possible, providing a good-quality anastomosis without diminishing the oncologic characteristics of the intervention.
FACTORS INVOLVED IN THE CONTROL OF GELATINOUS CURD DEFECTS OF COTTAGE CHEESE

Field: Agricultural and Biological Sciences (Life Sciences)

Fruitiness, caused by growth of Pseudomonas fragi, was the defect that most commonly limited the storage life of commercial cottage cheese. Cultures of Pseudomonas fragi, Pseudomonas viscosa, and Alcaligenes metalcaligenes produced typical defects in cottage cheese at initial pH values as low as 4.6 and at temperatures as low as 3.5° C. Low temperature was very effective as a means of retarding the development of defects. Of the species studied, P. fragi was retarded least by low temperature. Violet red bile agar was found satisfactory for enumeration of the three species of bacteria.