jimnoneill/paper-to-field-training huggingface dataset:
Formation of flavin semiquinone during the reduction of P450 BM3 reductase domain with NADPH

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Conference Article| February 01 1996 Formation of flavin semiquinone during the reduction of P450 BM3 reductase domain with NADPH Andrew W. Munro; Andrew W. Munro 1Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow. G12 8QQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar John R. Coggins; John R. Coggins 1Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow. G12 8QQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar J. Gordon Lindsay; J. Gordon Lindsay 1Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow. G12 8QQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar Simon Daff; Simon Daff ∗Department of Chemistry, University of Edinburgh, Kings Buildings, Mayfield Road, Edinburgh, U.K. Search for other works by this author on: This Site PubMed Google Scholar Stephen K. Chapman Stephen K. Chapman ∗Department of Chemistry, University of Edinburgh, Kings Buildings, Mayfield Road, Edinburgh, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1996) 24 (1): 18S. https://doi.org/10.1042/bst024018s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Andrew W. Munro, John R. Coggins, J. Gordon Lindsay, Simon Daff, Stephen K. Chapman; Formation of flavin semiquinone during the reduction of P450 BM3 reductase domain with NADPH. Biochem Soc Trans 1 February 1996; 24 (1): 18S. doi: https://doi.org/10.1042/bst024018s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1996 Biochemical Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
Intercultural teaching and learning in Chinese higher education: integrating practices and perspectives

Field: Social Sciences (Social Sciences)

sponsorship: We would like to thank the European Commission for co-funding the RICH-Ed project under the Erasmus + Programme (Action Type: Capacity Building in HE; project reference number - 585733-EPP-1-2017-1-BE-EPPKA2CBHE-JP) and all participating universities in China and Europe for the co-sponsorship. (European Commission|585733-EPP-1-2017-1-BE-EPPKA2CBHE-JP)
A Practical Method for Real-Time Optical Imaging of Damage Zone and Microscale Failure in Bone

Field: Medicine (Health Sciences)

Bone is an extremely complex composite material with hierarchical organization ranging from the molecular level all the way up to macroscale. The damage process too evolves through this hierarchy (1). Much of the damage process of bone is well understood at the macroscale level (2); however, microscopic and submicroscopic levels of bone damage are still poorly understood.
Multiple Calcifying Epitheliomas of Malherbe’s of Axilla: A Case Report of Rare Variety

Field: Medicine (Health Sciences)

Pilomatrixoma, a rare benign tumour of sebaceous gland is commonly known as calcifying epithelioma of Malherbe or Tricholemmal cyst. We came across even the rarest form of this benign tumour of skin. Our case report was interestingly detected at a higher age group, unusual site of the body, multiple in nature following postoperative incision drainage of abscess in left axilla.
[The efficiency of Rhadinopsylla rothschildi and R. dahurica fleas as vectors of the causative agent of plague in a Transbaikal natural focus].

Field: Immunology and Microbiology (Life Sciences)

Experiments have shown that a block of proventriculus arises in 2.1 to 12.5% of infected fleas of R. rothschildi and in 7.2 to 10.5% of R. dahurica. These fleas transmit the plague agent to different animals (Brandt's vole, narrow-skulled vole, Dahurian suslik). The plague microbe is preserved in the organism of infected insects till the end of the experiment, 74 and 24 days respectively. Therefore, the fleas can play a part in the maintenance of plague epizootics in the Transbaikal natural nidus.
Age determination among different age groups using enamel-etching patterns: Scanning electron microscopy analysis

Field: Dentistry (Health Sciences)

Background: The determination of age and sex is among the important aspects of forensic anthropology and vital in medicolegal investigations. Enamel is the hardest known substance in the human body. As tooth matures, the surface layer of the enamel presents hypermineralization features, which could influence the features of the etching pattern. Aim: The purpose of the present study is to assess if the enamel surface can be used as a parameter to determine the age. Materials and Methods : Sixty freshly extracted teeth from individuals with known age group were collected and etching procedure was done, and then subjected to scanning electron microscope analysis. Statistical Analysis: Chi-square test was done using SPSS software (Statistical Package for the Social Sciences (SPSS), USA).Results and Conclusion: The predominant etching pattern seen in 20-30 year age group after acid etching for 15 s is Type I pattern (66%), while in 50-60 year age group, it is Type II pattern (61.6%). A significant difference was observed in the respective age groups among the type of etching pattern. This technique can be a very useful adjunct for age determination in the field of forensic odontology.
Routine pap smears for the diagnosis of bacterial vaginosis

Field: Medicine (Health Sciences)

This study investigated the role of Papanicolaou (Pap) smears in determining the presence of bacterial vaginosis (BV). Pap results, vaginal Gram stains, signs, symptoms, and wet mounts were evaluated. Vaginal smears for Gram stain and routine Pap smears were collected from 420 consecutive patients. Ninety-three percent of patients with Pap smears showing only coccobacilli had a corresponding BV-positive Gram stain. Pap smears with mixed bacterial patterns had 22–71% positive Gram stains depending on the types of bacteria present. Only 10 of 70 symptomatic patients and 13 of 132 with cervicitis or discharge had a positive Gram stain and/or an altered bacterial pattern. All positive wet mounts had positive Gram stains and coccobacilli only on Pap smears. The most specific diagnosis of BV with Pap smears requires coccobacilli only. This reiterates the Bethesda system criteria. Clinical signs, physical symptoms, and wet-mount examinations were noncontributory in this study. Diagn. Cytopathol. 1999;21:10–13. © 1999 Wiley-Liss, Inc.
WORKPIECE SHAPE ERRORS IN ELECTROCHEMICAL MACHINING

Field: Engineering (Physical Sciences)

Experimental and analytical investigations are conducted to determine the profile change along the frontal inter-electrode gap (IEG) in the course of electrochemical machining.The interelectrode machining parameters are described mathematically in the steady state condition and a computer program is developed to solve the obtained formulae.A comparison between theoretical and experimental results are also carried out.A discussion of certain limitations to the ECM process is presented.
Comparison of Macroeconomics Variables among European Union and East Asian Countries

Field: Economics, Econometrics and Finance (Social Sciences)

European Union is extremely integrated market with more than 500 million consumers searching for quality goods. EU trading bloc is largest exporter to more than 80 countries and 71 per cent imports enter in EU region at reduced or sometimes at zero tariffs. Still EU has having motivated agenda with other world for a number of trade agreements in the pipeline. Basic idea behind this research study is, whether EU trading bloc has improved the performance of member countries or not? Research study finds that EU trading bloc has increased the production and welfare of the peoples in EU region. Now, it is suggestion for East Asian countries to make East Asian Trading Bloc (EATB) for improved performance and better wellbeing of the people in near future. This study presents the new regression estimates of relationship among openness of trade and Foreign Direct Investment inflows for Bangladesh, China, India, Malaysia, Nepal, New Zealand, Pakistan, Philippines, Sri Lanka and Thailand over the period 1982-2013. Fixed effect and Pooled OLS techniques are used to analyze the panel data for measuring individual country effects, group effects and time effects while exploring the relationship among openness of trade and FDI inflows. Results showed that higher openness of trade have significant positive impact on FDI inflows. The results also investigated that FDI inflows seem to be affected significantly by conventional determinants like as Exchange rate and GDP per capita etc. Based on results the authors have concluded that increase in trade openness would be a better option for more and sustained FDI inflows for the long run and also improving the welfare of the people.
Ruin of the mortuary chapel at Mission Tumacacori, from the roof of the church, Arizona, ca.1908

Field: Arts and Humanities (Social Sciences)

Photograph (from the roof of the church) of the ruin of the mortuary chapel at Mission Tumacacori, Arizona, ca.1908. The cylindrical stone structure has no roof. It sits in the middle of a graveyard enclosed by a wood fence. Three piles of stones from the ruin lay on the ground at bottom. Small trees and scrub brush grow in the distance.
Treatment of Metastatic Pheochromocytoma and Paraganglioma With 131I-Meta-Iodobenzylguanidine (MIBG)

Field: Medicine (Health Sciences)

Pheochromocytomas and paragangliomas (extra-adrenal pheochromocytomas) are relatively rare catecholamine-producing tumors that arise from chromaffin tissue. Radionuclides, such as 131I-meta-iodobenzylguanidine (MIBG), a guanidine derivative, present an imaging modality that has been used for both the diagnosis and staging of chromaffin-cell tumors. Malignant chromaffin-cell tumors account for 10–20% of all cases of chromaffin-cell tumors and show a variable natural history, from a locally invasive indolent tumor to a highly aggressive malignancy. These tumors are best managed by a multidisciplinary team aiming not only at tumor bulk reduction, but also at control of the hypersecretory syndromes resulting from catecholamine excess and maintaining a good quality of life. Surgery with complete resection or debulking of the primary tumor is the treatment of choice, but for disseminated tumors, additional treatment is required. However, systemic chemotherapy has not been shown to be consistently effective, whereas external radiotherapy is mainly reserved for the treatment of localized bony metastases. Pheochromocytomas and paragangliomas that demonstrate positive uptake on a diagnostic 131/123I-MIBG scan can be treated with 131I-MIBG, thus presenting a novel and evolving therapeutic modality in addition to the other traditional therapeutic approaches. In cases with locally aggressive disease, 131I-MIBG therapy is given to complement surgery to help achieve the total eradication of the tumor. In more advanced cases with disseminated disease, 131I-MIBG therapy aims at palliation of symptoms and reduction of tumor function, as well as tumor arrest or even regression after surgery. Treatment with 131I-MIBG is associated with considerable symptomatic and hormonal responses, but fewer patients achieve a tumor response. However, there is stabilization of the disease in the majority with a substantial improvement in the quality of life. 131I-MIBG therapy is safe and well tolerated with minimal adverse effects, although prolonged follow up is still necessary. Although a randomized, controlled study to access the efficacy of 131I-MIBG treatment and its integration with other forms of therapy is awaited, it remains a valuable alternative or additional therapeutic option to the currently available treatment modalities.
VoronoiNet : General Functional Approximators with Local Support

Field: Computer Science (Physical Sciences)

Voronoi diagrams are highly compact representations that are used in various Graphics applications. In this work, we show how to embed a differentiable version of it -- via a novel deep architecture -- into a generative deep network. By doing so, we achieve a highly compact latent embedding that is able to provide much more detailed reconstructions, both in 2D and 3D, for various shapes. In this tech report, we introduce our representation and present a set of preliminary results comparing it with recently proposed implicit occupancy networks.
Measurement of Resveratrol Content in Grape Wine and Analysis of Its Correlations with Environmental Factors

Field: Agricultural and Biological Sciences (Life Sciences)

Ethyl acetate(its volume 2 times of wine samples) was used to extract resveratrol and the extract was condensed to 1/100 of original wine sample volume.Then C18 reversion phase chromatography column was used and methanol:water = 5:5 used as mobile phase to separate chromatographic peaks of resveratrol.By using trans-resveratrol(Sigma) as the standards,resveratrol content in grape wine samples of different production places or of different varieties were determined respectively,and the correlation between resveratrol content in grape wine and various environmental factors were analyzed.The results suggested that grape wine from turpan(Xinjiang province),Changli(Hebei province) and Deqin(Yunnan province) had relatively higher content of resveratrol,which proved that resveratrol content in grape wine was closely related to the latitude of wine-making places.
Pecan Bud Moth:1Captures in Georgia in Traps Baited with the Pheromone of the Oriental Fruit Moth13

Field: Agricultural and Biological Sciences (Life Sciences)

Male pecan bud moths, Gretchena bolliana (Slingerland), were captured during the spring flights (April–May) in traps placed in the canopy of pecan trees and baited with 2 μ1 of ( Z )-8-dodecenyl acetate, a synthetic sex pheromone of the oriental fruit moth, Grapholitha molesta (Busck), containing 7% E isomer and 2 μ1 of dodecyl alcohol (a synergist). Pheromone traps placed 9.1 m above ground caught more male pecan bud moths than those at lesser heights. During the summer and fall flights (June –Oct.), appreciable numbers of male pecan bud moths were caught in unbaited blacklight traps.
Simultaneous occurrence of type I diabetes mellitus and juvenile rheumatoid arthritis.

Field: Medicine (Health Sciences)

The association of juvenile rheumatoid arthritis and type 1 diabetes mellitus is rare. These two diseases belong to different clusters of autoimmune diseases and it is uncommon for diseases belonging to different cluster occurring together. This is a case report of a fourteen-year-old girl having the above two disorders along with autoimmune thyroid disease.
Tethered spinal cord

Field: Medicine (Health Sciences)

In a radiological study, termination of conus medullaris below L2 vertebral level is considered tethering of the cord. However, tethered cord syndrome (TCS) is the constellation of symptoms and signs of motor and sensory dysfunction that are caused by excessive traction and tension on the spinal cord [1]. A majority of cases with TCS are associated with anomalies in nervous system development and are related to spinal dysraphism. Completely intradural processes such as lipoma of filum terminale (Fig. 98.1), abnormal fibrous adhesions, and shortened filum terminale are also associated with tethered cord. They are sometimes known as primary TCS, with terms like tight filum, fatty filum, and filum terminale syndrome [1]. Closed spinal dysraphisms such as lipomyelomeningocele, diastematomyelia, neurenteric cyst, lumbosacral lipoma (Fig. 98.2), dermal sinus, and thickened filum terminale are increasingly associated with tethered cord [2]. Almost all children born with open spinal dysraphisms such as spinal meningoceles (Fig. 98.3), myelomeningocele (Fig. 98.4), and myeloschisis have tethered cord [3]. More recently, TCS has been broadened to include patients with tethering of cervical or thoracic cord, and also patients with increased tension on the lower cord, in spite of having a normal position of conus [1]. TCS is also been associated with diverse conditions including trauma, infection, and neoplasm.
What Do I Do with Contexts? A Brief Reflection on Reading Biblical Texts with Israel and Aotearoa New Zealand in Mind

Field: Arts and Humanities (Social Sciences)

How does one “do” biblical studies contextually? If I begin by asking who am I, where am I situated, and what are the communities that have formed and continue to form who I am, what difference will this make to the way in which I “do” my biblical studies? This paper seeks to explore the issues that an engagement with texts which have their own contexts and interests brings for a Pakeha reader from Aotearoa New Zealander, recognising that this is not an easy or comfortable task, but an enterprise that continually raises questions and stretches boundaries.
THREE YEARS OF EXPERIENCE WITH INDORAMIN

Field: Medicine (Health Sciences)

1 One hundred and eight patients were enrolled into an open long-term assessment of indoramin. All patients were initially treated with indoramin alone. After 6 weeks patients whose blood pressure was not satisfactorily controlled had a diuretic (hydrochlorothiazide) added. If after a further 4 weeks the blood pressure was still not controlled propranolol was added to indoramin and diuretic. 2 Twelve months' treatment were completed by 39 patients on indoramin alone, 32 on indoramin and diuretic and 29 on indoramin, diuretic and propranolol. All treatment groups reduced supine diastolic blood pressure to below 90 mm Hg. 3 Eight patients failed to complete treatment, three being withdrawn from treatment because of side-effects and five for non-treatment reasons. 4 The commonest side-effects were sedation, dry mouth, increase in appetite and failure of ejaculation. Three patients were withdrawn because of this effect but the other patients remained on treatment. All side-effects were reported in the early weeks of treatment, thereafter the effects appeared to tolerate out. 5 Sixty-nine patients on indoramin or indoramin and diuretic completed 2 years of treatment and 37 completed 3 years of treatment, the blood pressure being maintained below 90 mm Hg diastolic. A majority of patients were either maintained on the same dose or had the dose reduced.
An Alternative Framework of Estimating Investment and Saving Functions for Developing Countries: An Application to Time-Series Data for Sub-Sahara African Countries

Field: Economics, Econometrics and Finance (Social Sciences)

The study adopts the reduced-form approach that is within the flow-of-funds framework in examining determinants of investment, domestic saving and foreign saving. Time-series annual data for 25 Sub-saharan countries are employed and six possible determinants are considered, with their general primary effects being as follows: (i) foreign reserves availability promotes investment (ii) real interest rate has rather ambiguous effects (iii) change in GDP promotes investment and domestic saving and retards foreign saving (iv) domestic credit availability enhances investment (v) world economic growth reduces foreign saving and (vi) real exchange rate devaluation reduces investment and foreign saving. These primary effects are also with the expected Spillover effects. [O55]
A novel mutation in the connexin 26 gene (GJB2) in a child with clinical and histological features of keratitis–ichthyosis–deafness (KID) syndrome

Field: Medicine (Health Sciences)

Summary Background. Keratitis–ichthyosis–deafness (KID) syndrome is a rare congenital ectodermal disorder, caused by heterozygous missense mutation in GJB2, encoding the gap junction protein connexin 26. The commonest mutation is the p.Asp50Asn mutation, and only a few other mutations have been described to date. Aim. To report the fatal clinical course and characterize the genetic background of a premature male neonate with the clinical and histological features of KID syndrome. Methods. Genomic DNA was extracted from peripheral blood and used for PCR amplification of the GJB2 gene. Direct sequencing was used for mutation analysis. Results. The clinical features included hearing impairment, ichthyosiform erythroderma with hyperkeratotic plaques, palmoplantar keratoderma, alopecia of the scalp and eyelashes, and a thick vernix caseosa-like covering of the scalp. On histological analysis, features characteristic of KID syndrome, such as acanthosis and papillomatosis of the epidermis with basket-weave hyperkeratosis, were seen. The skin symptoms were treated successfully with acitretin 0.5 mg/kg. The boy developed intraventricular and intracerebral haemorrhage, leading to hydrocephalus. His condition was further complicated by septicaemia and meningitis caused by infection with extended-spectrum beta-lactamase-producing Klebsiella pneumoniae. Severe respiratory failure followed, and the child died at 46 weeks of gestational age (13 weeks postnatally). Sequencing of the GJB2 gene showed that the child was heterozygous for a novel nucleotide change, c.263C&gt;T, in exon 2, leading to a substitution of alanine for valine at position 88 (p.Ala88Val). Conclusions. This study has identified a new heterozygous de novo mutation in the Cx26 gene (c.263C&gt;T; p.Ala88Val) leading to KID syndrome.
Calcium Influx-Dependent and -Independent α1-Adrenoceptor-Mediated Processes of Vasoconstriction In Vivo Do Not Operate via Different α1-Adrenoceptor Subtypes

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Summary: In pithed rats, the selective α1-adrenoceptor agonists St 587 and cirazoline show preponderant calcium influx-dependent and -independent vasoconstriction, respectively. By using these agonists, selective (competitive) antagonists for either process of vasoconstriction were sought. For this purpose, antagonism was analyzed for eight structurally different antagonists (prazosin, BE 2254, AR-C239, R 28935, corynanthine, phentolamine, sulpiride, and chlorpromazine) opposing the pressor responses evoked by cirazoline and St 587. Where pA2 values ( -log dose antagonist evoking a twofold shift for the agonist dose-response curve) could be calculated, no significantly different pA2 values against either agonist resulted. However, with respect to the slopes of the Schild plots, deviations from unity were found for prazosin, R 28935, AR-C239, sulpiride, and chlorpromazine, but not uniformly against both agonists. Following treatment with phenoxybenzamine (PB) (30 μg/kg) and nifedipine (1 mg/kg), which produced calcium influx-sensitive and -insensitive vasoconstriction to cirazoline, respectively, Schild plots were constructed for BE 2254, prazosin, and chlorpromazine. Using cirazoline as an agonist, unity slopes were now obtained for prazosin and chlorpromazine. The Schild plots of BE 2254 versus cirazoline after PB or nifedipine administration, however, exhibited a slope deviating from unity. For prazosin and chlorpromazine, identical pA2 values still resulted against both processes of vasoconstriction to cirazoline. The results are compatible with the view that α1-adrenoceptors mediating calcium influx-dependent and -independent vasoconstriction in vivo are not distinctly different entities, but are separate recognition sites of the same receptor.