jimnoneill/paper-to-field-training huggingface dataset:
MRI/MRS assessment of in vivo murine cardiac metabolism, morphology, and function at physiological heart rates

Field: Medicine (Health Sciences)

Transgenic mice are increasingly used to probe genetic aspects of cardiovascular pathophysiology. However, the small size and rapid rates of murine hearts make noninvasive, physiological in vivo studies of cardiac bioenergetics and contractility difficult. The aim of this report was to develop an integrated, noninvasive means of studying in vivo murine cardiac metabolism, morphology, and function under physiological conditions by adapting and modifying noninvasive cardiac magnetic resonance imaging (MRI) with image-guided 31 P magnetic resonance spectroscopy techniques used in humans to mice. Using spatially localized, noninvasive 31 P nuclear magnetic resonance spectroscopy and MRI at 4.7 T, we observe mean murine in vivo myocardial phosphocreatine-to-ATP ratios of 2.0 ± 0.2 and left ventricular ejection fractions of 65 ± 7% at physiological heart rates (∼600 beats/min). These values in the smallest species studied to date are similar to those reported in normal humans. Although these observations do not confirm a degree of metabolic scaling with body size proposed by prior predictions, they do suggest that mice can serve, at least at this level, as a model for human cardiovascular physiology. Thus it is now possible to noninvasively study in vivo myocardial bioenergetics, morphology, and contractile function in mice under physiological conditions.
Highly Effective Personal Training: An Evidence-Based Review of Teaching Strategies

Field: Health Professions (Health Sciences)

A COMMANDING ASPECT OF PERSONAL TRAINING CENTERS ON THE ATTRIBUTES AND ABILITIES IN TEACHING CLIENTS. WHAT ARE THE ELEMENTS OF EXCELLENCE IN INSTRUCTION? THIS EVIDENCE-BASED BRIEF REVIEW ON THIS TOPIC WILL PROVIDE ASPIRING FITNESS PROFESSIONALS WITH NOTEWORTHY RESEARCH ON EFFECTIVE TEACHING AND A TAXONOMY (I.E., CLASSIFICATION BY CATEGORIES) OF PERSONAL TRAINING TEACHING EXCELLENCE.
700V Lateral DMOS with New Source Fingertip Design

Field: Engineering (Physical Sciences)

For decades of years, the most advanced commercial LDMOS was made by double RESURF technique using p-type Held shaping layer until dual current path LDMOS which has triple RESURF structure. The specific on resistance of LDMOS was reduced to about 60% comparing to conventional LDMOS by using buried p-type field shaping layer which make it possible to get triple RESURF structure for LDMOS. The crucial point to get low specific on resistance of LDMOS is also source fingertip design because large source radius to avoid electric field concentration causes poor specific on-resistance characteristics. This paper presents high voltage LDMOS with two types of RESURF structure which has different charge balances to get lower specific on-resistance and high sustaining voltage at the same time.
The rabbit-friendly practice

Field: Veterinary (Health Sciences)

Veterinary surgeons must make animal health and welfare the first consideration when attending to animals. With the increase in the number of rabbits being presented for veterinary care, practices should aim to promote the reduction of stress in the surgery and its associated negative impact on the welfare of patients. This chapter covers staff training, the waiting and consultation rooms, equipping the hospital ward, preventive healthcare and euthanasia. An example rabbit discharge sheet is included, together with client handouts.
THE ROLE OF DIGITAL MEDIA IN MAINTAINING LOCAL CULTURE INDONESIA IN THE ERA OF GLOBALIZATION

Field: Social Sciences (Social Sciences)

The era of globalization is marked by advances in information and communication technology that have an impact on the spread of information that can take place quickly and widely, not limited to developed countries with high economic growth, but also across the borders of poor and developing countries with low economic growth. For Indonesia, the influx of western values is a ride on the wave of globalization for Indonesian society which is a threat to the indigenous culture that describes the distinctive locality of the regions in this country. For example, young children may see pornographic images, teenagers who are supposed to be the cultural milestones of a nation that upholds hedonism and modernity. According to Dr. Hench, strategies are needed that actually take advantage of the role of digital media in counteracting negative influences from outside due to globalization, including websites, mobile applications, mobile games, and so on that can be used for the basis of the approach to spreading Indonesian culture through the internet with an emphasis on spreading through blogs and social media, making local media into national and international media capable of increasing the role of local culture in the world arena and finally implementing counter- culture, which is an effort from a local media to stem the influences from outside the media by highlighting the characteristics that come from the local community.outcomes of fourthgrade students of MI Ma'arif Slendro, Sragen Regency.
Early transcriptional response to gravistimulation in poplar without phototropic confounding factors

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract In response to gravistimulation under anisotropic light, tree stems showing an active cambium produce reaction wood that redirects the axis of the trees. Several studies have described transcriptomic or proteomic models of reaction wood relative to the opposite wood. However, the mechanisms leading to the formation of reaction wood are difficult to decipher because so many environmental factors can induce various signalling pathways leading to this developmental reprogramming. Using an innovative isotropic device where the phototropic response does not interfere with gravistimulation we characterized the early molecular responses occurring in the stem of poplar after gravistimulation in an isotropic environment, and without deformation of the stem. After 30 min tilting at 35° under anisotropic light, we collected the upper and lower xylems from the inclined stems. Controls were collected from vertical stems. We used a microarray approach to identify differentially expressed transcripts. High-throughput real-time PCR allowed a kinetic experiment at 0, 30, 120 and 180 min after tilting at 35°, with candidate genes. We identified 668 differentially expressed transcripts, from which we selected 153 candidates for additional Fluidigm qPCR assessment. Five candidate co-expression gene clusters have been identified after the kinetic monitoring of the expression of candidate genes. Gene ontology analyses indicate that molecular reprogramming of processes such as ‘wood cell expansion’, ‘cell wall reorganization’ and ‘programmed cell death’ occur as early as 30 min after gravistimulation. Of note is that the change in the expression of different genes involves a fine regulation of gibberellin and brassinosteroid pathways as well as flavonoid and phosphoinositide pathways. Our experimental set-up allowed the identification of genes regulated in early gravitropic response without the bias introduced by phototropic and stem bending responses.
Additional file 2 of Psychometric properties of a nationwide survey for adults with and without diabetes: the “disease knowledge and information needs – diabetes mellitus (2017)” survey

Field: Health Professions (Health Sciences)

Additional file 2. Scale distributions, reliability and unidimensional factor analyses for scales used in both survey components. The table presents scale distributions, Cronbach’s Alpha coefficient as well as results of confirmatory, i.e. unidimensional factor analyses for scales used in the two survey components: people with diagnosed diabetes and people without diagnosed diabetes.
EFFECTS OF SUPPLEMENTARY POTASSIUM AND PHOSPHORUS ON PHYSIOLOGICAL DEVELOPMENT AND MINERAL NUTRITION OF CUCUMBER AND PEPPER CULTIVARS GROWN AT HIGH SALINITY (NaCl)

Field: Agricultural and Biological Sciences (Life Sciences)

Two cucumber (Cucumis sativus) cultivars, Seraset F and Rabina F, and two pepper (Capsicum annuum) cultivars, California Wonder and Charliston 52, were grown hydroponically for six weeks to investigate the effectiveness of supplementary potassium (K) and phosphorus (P) applied to the root zone of plants grown at high (60mM) NaCl concentration. Treatments used in this experiment were (i) control: nutrient solution alone, (ii) high salt: nutrient solution plus 60 mM NaCl, and (iii) high salt with supplementary P and K: nutrient solution plus 60 mM NaCl, 1 mM KHPO, and 2 mM KSO. Supplementary 1 mM KHPO and 2mM KSO was added to nutrient solution for four weeks. Plants grown at high salt produced less dry matter and chlorophyll than those in normal nutrient solution for both cucumber and pepper cultivars. Reductions in both dry matter and chlorophyll concentrations were greater for pepper than cucumber. Supplementary K and P restored dry matter and chlorophyll concentrations for both species to levels similar to the control. Membrane permeability increased with high salt application and these increases were greater for pepper. Supplementary K and P restored membrane permeability in both species to levels similar to the control. Plant daily water use was decreased by high salt but it was restored with supplementary K and P to levels similar to the control. Sodium (Na) concentration in plant tissues increased for both species in the high salt treatment. Concentrations of P and K were in the deficient range in the plants grown at high salt and supplementary K and P application corrected these deficiencies.
Norm-Peak Multilinear Forms on the Plane with the Rotated Supremum Norm

Field: Mathematics (Physical Sciences)

Let 𝑛 ≥ 2. A continuous 𝑛-linear form 𝑇 on a Banach space 𝐸 is called norm-peak if there is a unique (𝑥 1 , … , 𝑥 𝑛 ) ∈ 𝐸 𝑛 such that ║𝑥 1 ║ = … = ║𝑥 𝑛 ║ = 1 and for the multilinear operator norm it holds ‖𝑇 ‖ = |𝑇 (𝑥 1 , … , 𝑥 𝑛 )|. Let 0 ≤ 𝜃 ≤ = ℝ 2 with the rotated supremum norm ‖(𝑥, 𝑦)‖ (∞,𝜃) = max {|𝑥 cos 𝜃 + 𝑦 sin 𝜃|, |𝑥 sin 𝜃 − 𝑦 cos 𝜃|}. In this note, we characterize all norm-peak multilinear forms on . As a corollary we characterize all norm-peak multilinear forms on = ℝ 2 with the 𝓁 𝑝 -norm for 𝑝 = 1, ∞.
U.S. Attitudes toward International Criminal Courts and Tribunals

Field: Social Sciences (Social Sciences)

This chapter aims to provide a description of U.S. policy on the subject of international criminal courts and tribunals, both at present and historically, and how that policy has been, and continues to be, developed. It is not intended to provide a critique of that policy. The merits of policy positions are examined only insofar as they shed light on the origins of or motivations underlying those positions.
Dampak Literasi Keuangan terhadap Kinerja Keuangan pada Usaha Mikro Kecil dan Menengah di Samarinda

Field: Business, Management and Accounting (Social Sciences)

The purpose of this group community service is to increase understanding of the importance of financial literacy on the financial performance of Micro, Small and Medium Enterprises in Samarinda. A lack of understanding in financial literacy has an impact on the limited ability of Micro, Small and Medium Enterprises to utilize existing financial products and services. The method used in the service is lectures and discussions with participants which are carried out in four stages consisting of identification, training in preparing financial reports, socialization on how to apply for loans, and evaluation. The results of the activity showed that before the socialization on financial literacy was held, only 35% of participants understood about financial products and services while understanding the importance of financial management, only 50% of the total participants. After the socialization, 85% of participants understood the importance of financial literacy and financial management to improve their financial performance and utilizing financial products and services optimally to increase their funding and financial performance. To further optimize this activity, continuous training and mentoring is needed in the form of coaching and training in the technical process of recording and making financial reports on Micro, Small and Medium Enterprises
Highly selective binding of the carcinogen benzo[a]pyrene diol epoxide to nuclear matrix/scaffold DNA

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Conference Article| December 01 1986 Highly selective binding of the carcinogen benzo[a]pyrene diol epoxide to nuclear matrix/scaffold DNA W.-S. THERESA TAM; W.-S. THERESA TAM 1Department of Biochemistry, Nottingham University Medical School, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: This Site PubMed Google Scholar ANDERSON J. RYAN; ANDERSON J. RYAN 1Department of Biochemistry, Nottingham University Medical School, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: This Site PubMed Google Scholar MICHAEL A. BILLETT MICHAEL A. BILLETT 1Department of Biochemistry, Nottingham University Medical School, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1986) 14 (6): 1164–1165. https://doi.org/10.1042/bst0141164 Article history Received: June 11 1986 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation W.-S. THERESA TAM, ANDERSON J. RYAN, MICHAEL A. BILLETT; Highly selective binding of the carcinogen benzo[a]pyrene diol epoxide to nuclear matrix/scaffold DNA. Biochem Soc Trans 1 December 1986; 14 (6): 1164–1165. doi: https://doi.org/10.1042/bst0141164 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: BP, benzo[a]pyrene, BPDE, benzo[a]pyrene-7,8-diol-9,10-epoxide, LIS, lithium di-iodosalicylate This content is only available as a PDF. © 1986 Biochemical Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.
Targeting retinoid receptors with dysregulated microNRAs in pancreatic duct adenocarcinoma

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Retinoid (i.e., vitamin A, all-trans retinoic acid and other synthetic derivatives of vitamin A) induce cell differentiation and growth via the interaction of retinoid receptors in various normal and malignant cells. In addition to the success of all-trans-retinoic acid -based differentiation therapy in acute promyelocytic leukemia, emerging attempt in the combination of RA therapy and traditional chemotherapy has been studied in various solid cancer. Retinoid receptors (RARA, RARB, RXRA, and RXRB) and retinoic acid were reported to be down-regulated in pancreatic duct adenocarcinoma (PDAC) compared to normal pancreas. Moreover, the reduced expression of retinoid receptors correlates with the expression of these markers involved in the cell differentiation and the epithelial-mesenchymal transition. Further analysis revealed that the expressions of RARA and RXRB are associated with the overall survival in PDAC patients. Reduced level of retinoid and their receptors is associated with worse survival outcomes in PDAC patients. Yet, the mechanism of the down-regulation of retinoid receptors is not well defined. miRNA, as a class of small non-coding RNAs, can incorporate into the RNA-induced silencing complex and post-transcriptionally regulate the mRNA expression typically by binding to the 3’ untranslated region (3’-UTR) of the complementary mRNA sequence. The aim of this study was to find out whether selected dysregulated miRNAs in PDAC are responsible for the decreased level of retinoid receptors. For this purpose, we first performed a bioinformatics research to reveal conserved target sequences for deregulated miRNAs within the 3’UTR region of retinoid receptor mRNA. Next, we investigated the expression of selected retinoid receptors and miRNAs in BxPC-3, DanG, MiaPaCa-2, Panc-1 cell lines and the Human Pancreatic Duct Epithelial (HPDE) cell line. Further, we investigated the expression level by manipulating the expression of selected miRNAs. We demonstrated that none of these miRNAs can target the selected retinoid receptors in vitro. Therefore, we conclude that dysregulated miR-138, miR-206, miR-613, miR-9 and miR-27a/b are not involved in the regulation of the expression of retinoid receptors in PDAC patients.
Use of Oral Cortisone in Paediatrics

Field: Medicine (Health Sciences)

SIMPLE GASTRIC ULCER AND CARCINOMA BDI ouIL pre-pyloric carcinomata frequently undergo peptic ulceration and may then present with the histological features of so-called " ulcer-cancer."We believe that the second possibility is inherently more likely.But, in any event, from a practical stand- point the main conclusion is unaffected by one's choice between these two possibilities.It is that pre-pyloric ulcers are commonly malignant and should be resected.Summary Among 375 patients with gastric carcinoma treated in the Radcliffe Infirmary there were 26 with some eviqence that the neoplasm might have arisen in a simple ulcer.There was good clinical evidence of chronic simple ulcer in only half the patients.The site of the neoplasm for the group -of 26 patients conformed with the distribution of carcinoma of the stomach and not with that of simple gastric ulcer.In three cases the carcinoma had apparently arisen at a site different from that of a pre-existing simple ulcer.We believe that most of these cases were examples of ulcerating carcinoma.In any event, the majority were prepyloric, and it is evident that pre-pyloric ulcers should be deemed malignant and treated by surgical resection.We wish to thank the physicians and surgeons of the Radcliffe Infirmary for permission to make the study out of which the present article arises.
Fcast Scalable Multicast File Distribution: Caching and Parameters Optimizations

Field: Computer Science (Physical Sciences)

Reliable data multicast is problematic. ACK/NACK schemes do not scale to large audiences, and simple data replication wastes network bandwidth. Fcast, “file multicasting”, combines multicast with Forward Error Correction (FEC) to address both these problems. Like classic multicast, Fcast scales to large audiences, and like other FEC schemes, it uses bandwidth very efficiently. Some of the benefits of this combination were known previously, but Fcast contributes new caching methods that improve disk throughput, and new optimizations for small file transfers. Fcast is the first product based on this technology, to our knowledge. This paper describes Fcast’s design, implementation, and API.
Gender, Class, and Human/Non-Human Fluidity in Théodore and Hippolyte Cogniards’ féerie, The White Cat

Field: Arts and Humanities (Social Sciences)

Abstract The Frères Cogniard produced immensely popular vaudeville féeries in the nineteenth century and among them most popular was The White Cat (1852), which grafts two tales together by Marie-Catherine d’Aulnoy: “The White Cat” and “Belle-Belle, or the chevalier Fortuné.” The féerie foregrounds gender, class, human/thing, and species fluidity, which undermines hierarchies supported by dichotomies that in very similar ways privilege men over women, the upperclass over lowerclass, persons over things, and human animals over non-human animals. The essay traces these different forms of fluidity, examining the role of marvelous in general and metamorphosis in particular in problematizing normative structures of identity and revealing their arbitrary nature.
γ-Aminobutyric Acid-producing Lactic Acid Bacteria from Kimchi : Potential Psychobiotics

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

γ-Aminobutyric acid (GABA) functions as the primary inhibitory neurotransmitter in mammals, numerous studies have demonstrated that direct ingestion of GABA effectively induces natural sleep and alleviates stress. Low doses of GABA reduce stress by modulating the autonomic nervous system, while high doses do so by modulating the central nervous system. The oral administration of GABA-producing lactic acid bacteria (LAB) to experimental animals has been shown to promote mental health and ameliorate neurological disorders, such as essential tremor and depression, and to have positive effects on diabetes, fibromyalgia, chronic fatigue, and pain in experimental animals. Consequently, diet supplementation with GABA-producing LAB offers a potential means of treating mental health and neurological disorders in humans. Furthermore, supplementation with GABA-producing LAB might have sleep-inducing and stress-relieving effects akin to those observed after GABA consumption. Numerous LAB strains in kimchi produce diverse metabolites, and a significant proportion generate GABA. Although further animal and clinical studies are required, kimchi-sourced GABA-producing LAB appear to be potential psychobiotics.
Towards experiments at the new ELI-NP facility

Field: Physics and Astronomy (Physical Sciences)

Abstract. The Extreme Light Infrastructure (ELI) Pan-European initiative represents a major step forward in quest for extreme electromagnetic fields. The Extreme Light In-frastructure – Nuclear Physics (ELI-NP) laboratory is one of the three pillars of the ELI project, that aims to use such extreme electromagnetic fields for nuclear physics and quantum electrodynamics research. At ELI-NP two ten petawatt high-power laser sys-tems together with a very brilliant narrow-width γ beam are the main research tools. Here the current status of the project and the experimental program related to nuclear research, which is under preparation at ELI-NP, are presented. 1 The ELI-NP project ELI-NP [1] is one of the three laboratories under construction, related the ELI project [2], the other two being laser-driven secondary beams in Prague, the Czech Republic [3] and attosecond pulsed lasers in Szeged, Hungary [4]. In 2012 the 293-million-euro ELI-NP project was approved by the European Commission. ELI-NP will host two ultra high-power 10 PW lasers and a gamma beam system (GBS) which will deliver laser and γ-ray beams with parameters beyond those available at the present-state-of-the-art machines. The main laboratory building covers an area of more than 12000 m2. Its lay-out