jimnoneill/paper-to-field-training huggingface dataset:
Controllers to Chase a High-Speed Evader Using a Pursuer with Variable Speed

Field: Computer Science (Physical Sciences)

This paper proposes a chasing controller to enable a pursuer to chase a high-speed evader such that the relative distance between the evader and the pursuer monotonically decreases as time passes. Our controller is designed to assure that the angular rate of Line-of-Sight joining the pair (the pursuer and the evader) is exactly zero at all time indexes. Assuming that the pursuee can readily observe optical flow, but only poorly detect looming, this pursuer’s movement is hardly detected by the pursuee. Consider the terminal phase when the pursuer is sufficiently close to the evader. As we slow down the relative speed of the pursuer with respect to the evader, we can reduce the probability of missing the high-speed evader. Thus, our strategy is to make the pursuer decrease its speed in the terminal phase, while ensuring that the distance between the evader and the pursuer monotonically decreases as time passes. The performance of our controller is verified utilizing MATLAB simulations.
Machine learning based methods to generate conformational ensembles of disordered proteins (len54)

Field: Computer Science (Physical Sciences)

data is in rep_1 for all sequences, which contains the trajectory (xtc) file, Rg information (in the file Rg.out), pairwise distance information (in the file traj_analysis_data/pairwise_distance_matrix.csv) and the bspline coefficients (in the file bspline_info/xyz_coeff.npy)
Labtracker+ , a medical smartphone app for the interpretation of consecutive laboratory results: an external validation study

Field: Health Professions (Health Sciences)

Objectives When monitoring patients over time, clinicians may struggle to distinguish ‘real changes’ in consecutive blood parameters from so-called natural fluctuations. In practice, they have to do so by relying on their clinical experience and intuition. We developed Labtracker+ , a medical app that calculates the probability that an increase or decrease over time in a specific blood parameter is real, given the time between measurements. Design We presented patient cases to 135 participants to examine whether there is a difference between medical students, residents and experienced clinicians when it comes to interpreting changes between consecutive laboratory results. Participants were asked to interpret if changes in consecutive laboratory values were likely to be ‘real’ or rather due to natural fluctuations. The answers of the study participants were compared with the calculated probabilities by the app Labtracker+ and the concordance rates were assessed. Setting and participants Medical students (n=92), medical residents from the department of internal medicine (n=19) and internists (n=24) at a Dutch University Medical Centre. Primary and secondary outcome measures Concordance rates between the study participants and the calculated probabilities by the app Labtracker+ were compared. Besides, we tested whether physicians with clinical experience scored better concordance rates with the app Labtracker+ than inexperienced clinicians. Results Medical residents and internists showed significantly better concordance rates with the calculated probabilities by the app Labtracker+ than medical students, regarding their interpretation of differences between consecutive laboratory results (p=0.009 and p<0.001, respectively). Conclusion The app Labtracker+ could serve as a clinical decision tool in the interpretation of consecutive laboratory test results and could contribute to rapid recognition of parameter changes by physicians.
Paratextual play: Unlocking the nature of making-of material of games

Field: Arts and Humanities (Social Sciences)

Similar as to how films are accompanied with bonus features and extras on their dvd release, digital games too are sometimes released with supplemental materials which provide insight in the creative development process. Examples of these are behind-the-scenes documentaries, concept art, audio commentaries, and so on. In the study of digital games this material could easily be overlooked or primarily seen as marketing material outside and therefore not part of a game itself. This paper will discuss a shift in the paratextual location and function of making-of material from an external to internal or even integral part of the digital game experience. In some contemporary games, making-of material has become a feature which has a visible presence during play, and at times can only be accessed by unlocking them, which invites players to forms of paratextual play. In these play situations, paratext and text entangle, resulting not just in a potential shaping of the understanding but also of the playing of digital games, making them part of players’ gaming capital. By engaging with this type of making-of material, players are not just framed as knowledgeable insider in the creative process of game design but also acknowledged expert in terms of gaming prowess, requiring us to rethink how we approach making-of material as paratexts.
New BTK Inhibitors May Combat Resistance in CLL

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Three trials report positive data for the noncovalent Bruton tyrosine kinase inhibitor pirtobrutinib and a potential successor, rocbrutinib, in chronic lymphocytic leukemia. One study of previously untreated patients found a 24-month progression-free survival of 93.4% for pirtobrutinib, versus 70.7% for bendamustine and rituximab. The second study suggests the drug is noninferior to the covalent inhibitor ibrutinib in previously untreated or relapsed or refractory patients. The third study found an overall response rate of 62.5% for rocbrutinib in previously treated patients.
Rejuvenation Heat Treatment Development to Extend the Service Life of René N4 Single Crystal Gas Turbine Blades

Field: Materials Science (Physical Sciences)

Abstract Single crystal superalloys are widely used for gas turbine blades exposed to high stresses, high temperatures in aggressive environments. When these components reach their serviceable limit, they must be replaced by new ones, with an important impact in terms of maintenance costs. Significant savings can be achieved through the application of a rejuvenation heat treatment, able to extend the life of a serviced turbine blade beyond its original design intent and avoid parts scrap. The success of such a technology for SX-superalloys is related to the effective restoration of the original γ/γ’ microstructure, which is linked to the material mechanical properties, without impairing the original single crystal structure. Indeed, one challenge in designing a rejuvenation heat treatment for single crystal superalloys is the risk of recrystallization, which must be kept under control. This work is focused on the development of a rejuvenation heat treatment for René N4 alloy. Different rejuvenation cycles have been explored through an in-depth material characterization, using samples taken from both new material and real serviced gas turbine blades. Several solutioning heat treatments have been investigated in a window ranging from the theoretical γ’ solvus temperature and the original solutioning temperature used during blades manufacturing. The assessment of the candidate rejuvenation heat treatments effectiveness is based on the evaluation of microstructure γ/γ’ restoration and the presence of recrystallized grains.
Xylocaine gel 2% vs proparacaine 0.5% as topical anaesthesia in phacoemulsification in Bundelkhand: A prospective comparative study

Field: Medicine (Health Sciences)

Xylocaine gel 2% vs proparacaine 0.5% as topical anaesthesia in phacoemulsification in Bundelkhand: A prospective comparative study - IJCEO- Print ISSN No: - 2395-1443 Online ISSN No:- 2395-1451 Article DOI No:- 10.18231/2395-1451.2019.0011, Indian Journal of Clinical and Experimental Ophthalmology-Indian J Clin Exp Op
IODINE IN SURGICAL TUBERCULOUS DISEASE

Field: Medicine (Health Sciences)

IODINE IN SURGICAL TUBERCULOUS DISEASE.[ TMzrcBJouTn 39who are prevented by chronic ill-health from doing effec- tive work.Again, it is a disease to be fought because so many of our children with the best brains are attacked by it.If ever a teacher says to me that such and such a boy is the sharpest in the school, I always notice the lungs with extra care.Early Symptoms and Signs.The following remarks do not refer to cases in an advanced stage, children definitely ill, nor need I allude to the classical types of the tuberculous.Night swveating is a symptom concerning which one of my colleagues has no faith.He says that they all say they sweat.That seems to me only saying that " all men are liars," and needs qualification.There are certain distinctions to be made:1.If the sweating has existed all the child's life, it is probable the original cause was rickets.If it has started recently, or has existed in infancy, stopped, and started again, it has weight.2. If the sweating is not constant, but occurs from time to time, whenever the child catches cold (of course excluding the results of hot drinks at night).3. The sweating must be on the forehead or round the neck.It may he elsewhere as well, but, if the forehead is always dry, I am sceptical. 4. The sweating must be worse in cold weather. 5. Must not be due to heavy bedclothes.
Human Enzyme PADI4 Binds to the Nuclear Carrier Importin α3

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

PADI4 is a peptidyl-arginine deiminase (PADI) involved in the conversion of arginine to citrulline. PADI4 is present in macrophages, monocytes, granulocytes, and several cancer cells. It is the only PADI family member observed within both the nucleus and the cytoplasm. PADI4 has a predicted nuclear localization sequence (NLS) comprising residues Pro56 to Ser83, to allow for nuclear translocation. Recent predictors also suggest that the region Arg495 to Ile526 is a possible NLS. To understand how PADI4 is involved in cancer, we studied the ability of intact PADI4 to bind importin α3 (Impα3), a nuclear transport factor that plays tumor-promoting roles in several cancers, and its truncated species (ΔImpα3) without the importin-binding domain (IBB), by using fluorescence, circular dichroism (CD), and isothermal titration calorimetry (ITC). Furthermore, the binding of two peptides, encompassing the first and the second NLS regions, was also studied using the same methods and molecular docking simulations. PADI4 interacted with both importin species, with affinity constants of ~1–5 µM. The isolated peptides also interacted with both importins. The molecular simulations predict that the anchoring of both peptides takes place in the major binding site of Impα3 for the NLS of cargo proteins. These findings suggest that both NLS regions were essentially responsible for the binding of PADI4 to the two importin species. Our data are discussed within the framework of a cell mechanism of nuclear transport that is crucial in cancer.
Explosibility of Aluminum Powder-Silica Dust Clouds

Field: Chemical Engineering (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExplosibility of Aluminum Powder-Silica Dust CloudsRalph B. Mason and Cyril S. TaylorCite this: Ind. Eng. Chem. 1940, 32, 1, 67–68Publication Date (Print):January 1, 1940Publication History Published online1 May 2002Published inissue 1 January 1940https://pubs.acs.org/doi/10.1021/ie50361a013https://doi.org/10.1021/ie50361a013research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The nutrition of ruminants grazing native and improved pastures. I. Seasonal variation in the diet selected by grazing sheep and cattle

Field: Agricultural and Biological Sciences (Life Sciences)

The chemical composition of the forage on offer on a native pasture dominated by Poa sieberana and Themeda australis, on a similar native pasture dressed with superphosphate and oversown with white clover, and on two Phalaris aquatica (formerly tuberosa)–Trifolium repens pastures dressed with superphosphate and grazed at different stocking rates during summer, was determined at monthly intervals during 1974 and 1975. Samples were also plucked to simulate grazing in 1975, and extrusa were collected from oesophageally fistulated cattle in both years and from fistulated sheep in 1975. Digestibility and nitrogen content of the diet were determined, and in 1974 the extrusa were manually separated into green and senescent fractions. Samples of rumen liquor were also collected through rumen fistulae, and analysed for ammonia, and total and individual volatile fatty acids. The application of superphosphate and white clover, and the replacement of native grasses with Phalaris aquatica, both induced large increases in nutritive value measured in terms of digestibility, protein, macro- and micro-elements in the forage on offer and in the diet selected. Changes in the composition of the forage on offer were attributable to an increase in green material, and to the greater nutritive value of both green and senescent fractions as the extent of pasture improvement increased. Digestibility, nitrogen and mineral content of the diet selected by cattle and sheep increased with pasture improvement, the nutritive value of the diet selected by sheep being greater on all pastures although the difference was greatest on native pasture. The increase in nutritive value of the diet selected by cattle on improved pasture was associated with an increase in the green component of the diet and in the nutritive value of the green material selected.
Incorporating Peptide Aptamers into Resistive Pulse Sensing

Field: Computer Science (Physical Sciences)

<p>The use of nanocarriers within resistive pulse sensing, RPS, aids the detection and quantification of analytes. In the absence of convection, the signal strength and frequency can dependent upon the electrophoretic mobility of the nanocarrier/ analyte. Here we have developed a simple strategy to incorporate peptide aptamers onto RPS assays with enhanced electrophoretic signals. Using a hybrid DNA-Peptide nanocarrier an existing peptide was incorporated into a rapid assay without having to engineer or modify the peptide sequence. The surface of a nanocarrier is coated with a mixture of peptide aptamers and a nonbinding DNA. The binding of the target to the peptide creates an “analyte corona” which shields the phosphate groups of the underlying DNA. This results in a change in electrophoretic mobility of the nanocarrier. The signal is concentration dependent and is illustrated using a peptide to a key biomarker of infection, C-Reactive Protein, CRP. As a comparison we also show the binding of the CRP to a DNA aptamer. This universal approach can be easily adapted to other peptides without the peptide itself to undergo any chemical modifications opening new opportunities and applications in RPS strategies. </p>
Results concerning the Fusion Capacity of Some Cucurbits Grafted by Different Techniques

Field: Agricultural and Biological Sciences (Life Sciences)

The research was realized in 2014, in the Department of Horticultural Cultures in Protected Spaces at the Horting Institute of Bucharest, Romania.This aimed to study the fusion capacity of some cucurbits grafted by different techniques (one-cotyledon [1], cleft -V shaped [2] and by approach [3]) in order to emphasise the best grafting method according to survival rate data.The experience was conducted on two F 1 hybrids (Cucurbita type) as rootstocks -'TZ148' [T] and 'Shintoza' [S] and three F 1 hybrids as scions -'Mirabelle' [M] (cucumber), 'Vasko' [V] (watermelon) and 'Gina'[G] (melon).The best grafting method was with one-cotyledon, followed by cleft (V shaped) and by approach.The grafting method is very important for a successfull grafting.
MCU NODE BASED BLOOD GROUP DETECTION EQUIPPED WITH AN AUTOMATIC SAMPLE STIRER

Field: Health Professions (Health Sciences)

Blood type detection tool is a tool that can help In reading blood groups, you can find out the type of group blood with use sensors Light And LED, so in use tool This be equipped Gearboxes as stirrer sample automatic Which Where fluid reagent antisera will stirred with sample blood using the ABO method, results in sensor readings will be displayed on the LCD and also on the application when using Nodes MCU as the microcontroller, based on results testing tool This use 3 person with group blood Which The same on each Blood group samples are A, B, AB, O by comparing groups blood on card identity And results testing Which Where the result can obtained results Which The same. With mark flat flat group blood A is 0.6 and 2.1. As for blood type B, it is 1.7 and 1.1. As for AB blood type is 0.9 and 1.1. And blood type O is 2,3 And 2,3. whereas For mark error Which obtained group blood A that is 0.5 error value for blood group B i.e. 0.5 error value for blood group AB i.e 0.6, And error value for blood type O namely 0.2.
Genomics and Biomarker Research in Drug Development: Overrated, or a Revolution to Come?

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

At the basic science level, genomics and biomarker research have contributed great strides to our collective scientific knowledge and understanding of biological processes. Some of these research techniques have been applied to the field of drug development, permitting the new branch of pharmacogenomics to take shape. Although such research has promised to usher in an era of personalized medicine by providing unique treatments targeted to specific patient subgroups, progress in the field has been relatively slow thus far. To live up to its potential, researchers in the field must properly understand the inherent limitations of biomarkers, governmental regulations must adapt to changing technologies, and research must target clinically meaningful patient outcomes to make positive contributions to patient care.
Design of mobile radio transceiver RFICs: current status and future trends

Field: Engineering (Physical Sciences)

This paper gives an introduction to transceiver design for second and third generation wireless communications systems. Different transceiver front-end related testcase specifications and their relation to specific transceiver characteristics are explained. A review of some receiver architectures and their suitability for the two different systems followed by a perspective of future trends in transceiver front-end design is given.
Multistage W-Sn metallogenic processes in the Xitian ore field, South China: Evolution from skarn-type to vein-type mineralization

Field: Earth and Planetary Sciences (Physical Sciences)

The Nanling Metallogenic Belt is a major W-Sn province in South China containing numerous ore deposits formed during a complex history of magma emplacement and mineralization. The Xitian ore field in Hunan Province is a typical example of a late magmatic-metallogenic system. In this study, garnets from skarn-type ores in the Xitian ore field yield a U-Pb age of 231.7 ± 1.3 Ma (n = 33), whereas cassiterite grains from quartz vein-type ores give U-Pb ages of 158 to 154 Ma (n = 72) and 140.7 ± 3.3 Ma (n = 6), suggesting three stages of W-Sn mineralization (Late Triassic, Late Jurassic, and Early Cretaceous). In the Late Triassic skarn-type ores, the REE patterns of scheelite change from MREE-enriched to LREE-enriched with time, whereas the REE patterns of scheelite shift from MREE-enriched to MREE-depleted in the Late Jurassic quartz vein-type ores, indicating diverse metallogenic processes. Differences in the Y/Ho ratios and Sr-O isotope compositions of scheelite further confirm discrete metallogenic pathways for the Late Triassic skarn-type W ore and the Late Jurassic quartz vein-type ore, with fluid-rock interaction of the former dominated by magmatic-hydrothermal fluids whereas the latter was influenced by large amounts of meteoric water. A model emphasizing the evolution from skarn-type to vein-type metallogeny is proposed to account for the complex genesis of multistage W–Sn deposits related to the Xitian granite complex. More generally, this study demonstrates that in-situ LA-ICP(MC)-MS U-Pb dating and isotopic analysis of hydrothermal minerals are powerful tools to decipher the nature, timing, and evolution of multistage W-Sn metallogenic systems.
Reflections on EU Geopolitics: Consolidation, Neighbourhood and Civil Society in the Reordering of European Space

Field: Social Sciences (Social Sciences)

Civil society observations of the EU's geopolitical impacts on its immediate neighbourhood provide a nuanced 'ground-up' perspective that eschews historically deterministic interpretations of the EU's role in the world. While this article is limited to Eastern Europe, it nevertheless highlights some of the challenges facing the EU's visions of 'Neighbourhood' as multilateral and multilayered regional co-operation. After a brief theoretical introduction, the article first characterizes the EU's geopolitics as a dual project of consolidation and ideational projection; that is as two projects of re-ordering – re-territorializing – interstate relationships. It then addresses three specific and interrelated questions with regard to civil society: 1) how do the EU and its policies affect civil society co-operation agendas and practises, 2) to what extent does civil society participate in the co-development of Neighbourhood Policy and 3) how do civil society actors perceive the role of the EU in promoting cross-border and regional co-operation within the 'Neighbourhood'? One central issue in developing these questions is that of establishing 'common' European values as a condition for successful co-operation. Civil society actors must simultaneously operate within different, often competing, socio-political contexts. A balance between situational ethics and more generally accepted notions of (European) values is thus essential.