jimnoneill/paper-to-field-training huggingface dataset:
Abstract LB364: cIAP2 potentiates CD8+ T cells metabolic fitness and antitumor immunity

Field: Medicine (Health Sciences)

Abstract Checkpoint inhibition immunotherapy has revolutionized cancer treatment, but many patients show resistance. In this study, we perform integrative transcriptomic and proteomic analyses of emerging immuno-oncology targets across multiple clinical cohorts of melanoma undergoing anti-PD-1 treatment, examining both bulk and single-cell levels. We reveal a surprising role of CD8+ T cell-intrinsic cellular inhibitor of apoptosis 2 (cIAP2) in enhancing antitumor immunity, in contrast to its well-established role as an inhibitor of apoptotic death in tumor cells. The loss of cellular inhibitor of apoptosis protein 2 (cIAP2) expression serves as a marker of CD8+ T cell dysfunction, a critical phenotype associated with immunotherapy resistance.T cells within the solid tumor microenvironment (TME) must catabolize lipids through mitochondrial fatty acid oxidation (FAO) to generate energy during periods of nutrient stress. It is well-established that T cells enriched in FAO are highly effective in cancer control. However, endogenous tumor-infiltrating lymphocytes (TILs) and unmodified cellular therapy products do not effectively sustain bioenergetics within tumors. Here, we reveal that cIAP2 overexpression enhances the antitumor effects of CD8+ T cells by promoting their differentiation into a central memory T cell (TCM) phenotype via activation of the peroxisome proliferator-activated receptor (PPAR) signaling pathway, thereby facilitating a shift toward fatty acid metabolism.cIAP2 is a multifunctional protein that acts as an E3 ubiquitin ligase, regulating downstream targets. In this study, we employed deep learning techniques to construct a cIAP2 bait protein. We then performed docking analyses between the bait protein and a pre-established protein database. This process involved a sequential screening approach, starting with Megadock for initial screening, followed by Hdock for refined screening, and concluding with detailed one-on-one analysis using AlphaFold-Multimer. Ultimately, we identified the substrate protein monoacylglycerol lipase (MGLL). Mechanistically, we reveal that cIAP2 overexpression activates the PPAR signaling pathway by promoting the ubiquitin-proteasome degradation of MGLL. Our results indicate a complex role of cIAP2 in the tumor ecosystem, highlighting the cell-type-dependent antagonistic effects of a single target on immunotherapy. Citation Format: Jiazheng Sun, Qiao Wang, Dejuan Yang, Hongzhong Li. cIAP2 potentiates CD8+ T cells metabolic fitness and antitumor immunity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_2):Abstract nr LB364.
Unit trusts : a study on Asia Pacific funds

Field: Economics, Econometrics and Finance (Social Sciences)

This study is an evaluation of the performance of selected unit trusts in Singapore from the period, July 1993 to June 1994. The selected unit trusts were grouped into three categories according to the geographical location of the stock market in which the funds were invested. The methodology used to achieve the stated objective included analysis of the information complied and personal interviews with a few of the professional fund managers.
[Limitations and challenges of glucocorticoids in the treatment of paroxysmal nocturnal hemoglobinuria].

Field: Medicine (Health Sciences)

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disease that mainly occurs in young adults and is characterized by bone marrow failure, persistent intravascular hemolysis and thrombosis, all of which can cause severe end-organ damage, increase the risk of early death, and cause a severe disease burden in patients. In China, based on the historic reasons, glucocorticoids are still routinely used in many places. However, the effects of glucocorticoids on PNH hemolysis are uncertain. Evidence-based medical data and clinical benefits for glucocorticoid on PNH are missing, but the long-term use of glucocorticoids significantly increases the risk of adverse reactions in patients. Since PNH needs a lifelong follow-up and management, long-term glucocorticoid therapy will unavoidably seriously damage the health of patients. Therefore, glucocorticoids are not recommended for the treatment of PNH, either from domestic or overseas guidelines, or expert consensus. In this article, the limitations and challenges of glucocorticoids in the treatment of PNH were expounded upon, in order to encourage more effective and safe strategies to be accepted in China.
Training of Classroom Action Research for Science Teachers on Padang Pariaman’s SMPN 1, SMPN 2 Sintuk Toboh Gadang and SMPN 1 V Koto Kampung Dalam

Field: Social Sciences (Social Sciences)

To improve the quality of learning and reflect on learning outcomes are things that really improve science teacher profesionalism. That is the biggest motivation for Universitas Negeri Padang’s community service team to make a training session about science learning on Padang Pariaman’s. Understanding the classroom action reaserch, science teachers can solve the learning problems and write their own scientific work. The purpose of this training are teachers can make their own classroom action research and do their own research untill they can make theirown journals. The result shows that the training was good and reach the target that reaserchers make. 16th proposal finished are more than enough. Proposal are the result from traning, with a lot of revition before the proposal really finished.
Apsidal motion in the eclipsing binaries V1136 Cygni, ES Lacertae, MZ Lacertae and EQ Vulpeculae

Field: Physics and Astronomy (Physical Sciences)

About thirty new times of minimum light recorded with photoelectric means have been gathered for the early-type eccentric eclipsing binaries V1136 Cyg (P =3 :46 d ;e =0 :33), ES Lac (P =4 :46 d ;e =0 :20), MZ Lac (P =3 :16 d ;e =0 :42) and EQ Vul (P =9 :30 d ;e =0 :36). The O C diagrams are analyzed using all reliable timings found in the literature and new values for the elements of the apsidal motion are computed. We find new periods of apsidal motion of about 520, 300, 440 and 2200 years for V1136 Cyg, ES Lac, MZ Lac and EQ Vul, respectively.
Influence of Left–Right Asymmetries on Voice Quality in Simulated Paramedian Vocal Fold Paralysis

Field: Health Professions (Health Sciences)

Purpose The purpose of this study was to determine the vocal fold structural and vibratory symmetries that are important to vocal function and voice quality in a simulated paramedian vocal fold paralysis. Method A computational kinematic speech production model was used to simulate an exemplar “voice” on the basis of asymmetric settings of parameters controlling glottal configuration. These parameters were then altered individually to determine their effect on maximum flow declination rate, spectral slope, cepstral peak prominence, harmonics-to-noise ratio, and perceived voice quality. Results Asymmetry of each of the 5 vocal fold parameters influenced vocal function and voice quality; measured change was greatest for adduction and bulging. Increasing the symmetry of all parameters improved voice, and the best voice occurred with overcorrection of adduction, followed by bulging, nodal point ratio, starting phase, and amplitude of vibration. Conclusions Although vocal process adduction and edge bulging asymmetries are most influential in voice quality for simulated vocal fold motion impairment, amplitude of vibration and starting phase asymmetries are also perceptually important. These findings are consistent with the current surgical approach to vocal fold motion impairment, where goals include medializing the vocal process and straightening concave edges. The results also explain many of the residual postoperative voice limitations.
Verbascoside Derivatives and Iridoid Glycosides fromVerbascum Undulatum

Field: Chemistry (Physical Sciences)

Abstract On further phytochemical investigation of the aerial parts of Verbascum undulatum, a new iridoid glycoside, 6-O-[3-O-(trans-feruloyl)-α-L-rhamnopyranosyl] aucubin (1) and a new verbascoside derivative, 6-O-acetyl-martynoside (2) were isolated. These structures were determined by spectral methods, mainly by 1D and 2D NMR spectroscopy.
LHD 4-O_RU01 #164480.1 (analyzed)

Field: Physics and Astronomy (Physical Sciences)

Luminance data of the plasma monitor camera. Time variation of the average and maximum luminance within the ROI (Region of Interests) of the plasma images observed by the 4-O port camera, where ROI is (944,256) - (992,300) of the original image of 1920x1080. The luminance value is between 0 and 255 in arbitrary unit.
Editors’ Statement on the Responsible Use of Generative AI Technologies in Scholarly Journal Publishing

Field: Arts and Humanities (Social Sciences)

Generative artificial intelligence (AI) has the potential to transform many aspects of scholarly publishing. Authors, peer reviewers, and editors might use AI in a variety of ways, and those uses might augment their existing work or might instead be intended to replace it. We are editors of bioethics and humanities journals who have been contemplating the implications of this ongoing transformation. We believe that generative AI may pose a threat to the goals that animate our work but could also be valuable for achieving those goals. In the interests of fostering a wider conversation about how generative AI may be used, we have developed a preliminary set of recommendations for its use in scholarly publishing. We hope that the recommendations and rationales set out here will help the scholarly community navigate toward a deeper understanding of the strengths, limits, and challenges of AI for responsible scholarly work.
In-sync and on-track: self-regulation in preschoolers born very /extremely prematurely

Field: Psychology (Social Sciences)

INTRODUCTION: Self-regulation (SR) is a major childhood developmental achievement that predicts important preschool academic, adaptive, and psychosocial outcomes. Very or extremely premature (VP/EP) birth impacts cognitive development, however SR and related adaptive outcomes for this group of at-risk children are under-studied despite their importance to optimal outcomes. Consequently, the research goal was to examine the impact of premature birth on preschool SR and related areas and further to identify potential early predictors of risk. METHODS: This data-driven clinically derived study explored preschool SR outcomes in a convenience sample of 104 Manitoban children born VP/EP at 2 and 4 years of age. A novel SR framework incorporating ‘hot’ and ‘cool’ executive function (EF), behavioural, and adaptive components was examined using parent-report measures (Behavior Rating Inventory of Executive Function- preschool, Behavior Assessment System for Children- Parent Report System, Adaptive Behavior Assessment System- second edition) and individually administered cognitive and language measures. Cognitive and language scores were compared at two and four years of age. Scores for participants completing all measures (sample A, n = 60) were compared to participants who did not complete all measures (sample B, n = 44). FINDINGS: Sample A demonstrated poorer preschool adaptive, ‘cool’ EF, and atypical behaviour scores relative to test norms, of moderate to strong effect size. Principal Axis Factoring of parent report measures revealed 7 latent factors with Factors 1(Adaptive), 5(Internalizing), 6(Social Communication), and 7(Developmental) predicted by birth weight, brain injury, bronchopulmonary dysplasia, days of hospitalization, and/or chronological age. Cognitive and language scores for 4-year-olds were significantly correlated with preschool adaptive, behavioural and ‘cool’ EF scores. Sample B demonstrated more complex neonatal histories, greater adaptive (cognitive, practical, social) and externalizing concerns, and reduced likelihood of ‘catch-up’ between 2 and 4 years of age. IMPLICATIONS: The study’s In-Sync/On-track framework provides a useful lens to inform research and clinical monitoring of children born VP/EP. Findings revealed limitations to daily function and childhood SR prior to school entry, pointing to practice, policy and research implications, particularly for children with more complex medical histories who demonstrated higher levels of SR impairment but failed to complete testing.
Effect of Complexation With Phospholipids and Polarity of Medium on the Reactivity of Phenolic Antioxidants

Field: Chemistry (Physical Sciences)

The influence of the structure of isobornylphenols on their kinetic characteristics in the initiated oxidation of methyl oleate or ethylbenzene and autooxidation of methyl oleate in thin layer in mixtures with lecithin is studied, for example, 2-isobornyloxyphenol (I) and 2-isobornylphenol (II). The destruction of the intramolecular H-bond in I molecule while carrying out reactions in polar medium results in its increased ability to interact with peroxy radicals and the stable free radical diphenylpicryl- hidrazyl (DPPH). Effect of lecithin on the inhibitory efficiency of investigated isobornylphenols is found to depend on the initiation rate in the oxidation process and the ability of substances to form complexes with lecithin. In presence of isobornylphenols aggregates of lecithin both the size distribution of particles and the diameter of the main fraction depending on a polarity of medium change. Thus, isobornylphenols act upon the different parameters of the oxidation processes in the complex model systems. It allows us to suppose that the biological activity of isobornylphenols is due to their ability, both to influence on the different stages of the physicochemical regulatory system of the lipid peroxidation in tissues and to affect the structural state of the cell membranes. The data obtained help in checking the properties of various compounds on different model systems to carry out the preliminary choice of the most promising biologically active substances for practice use the medium polarity.
Model Pengembangan Keamanan Data dengan Algoritma ROT 13 Extended Vernam Cipher dan Stream Cipher

Field: Computer Science (Physical Sciences)

This research focuses on the importance of data security in maintaining confidentiality, particularly for sensitive and critical information that should only be accessed by certain parties. Cryptography is a mathematical method used to secure data. Several methods are available, including ROT13, Vernam Cipher, and Stream Cipher. This study combines these three methods to achieve a higher level of data security. The analysis shows that the combination of these algorithms results in a stronger and more complex encryption process than using a single method. The process involves encrypting plaintext using ROT13, followed by encrypting the result using Vernam Cipher with an inputted key, and then encrypting the output again using Stream Cipher. The advantages of this combination model include enhanced data security, as demonstrated by the three-stage encryption and decryption process.
Heritage Acculturation Is Associated With Contextual Factors at Four Different Levels of Proximity

Field: Psychology (Social Sciences)

What factors explain the extent to which members of cultural minorities maintain their heritage cultural engagement? Although this process, called heritage acculturation, has significant implications for adjustment, we know little about its antecedents. The present work sought to address two shortcomings of acculturation research: (a) the need to characterize antecedents of acculturation orientations and (b) the need to consider acculturation as a contextual phenomenon. Some studies have documented associations between acculturation and specific contextual variables (e.g., family socialization), but an important feature of this research was to examine the unique contribution of factors at multiple levels of proximity simultaneously. Specifically, this study considered intraindividual, home, social network, and neighborhood-level contextual correlates of heritage acculturation. The overarching hypothesis tested among multicultural university students in Canada ( n = 271) was that people whose life contexts are more strongly imbued with heritage cultural influences would report greater heritage acculturation. Results fully supported this hypothesis. Greater heritage language competence, “parental” living arrangements, a more extensive heritage social network, and living in an ethnically denser neighborhood were all related to greater heritage cultural maintenance. Further, only heritage network extensiveness was negatively related to mainstream cultural engagement—attesting to the cultural specificity of these associations. These results suggest that none of the four contextual levels considered here was sufficient on its own to understand participants’ heritage acculturation and that we need a holistic view of the person in her or his multiple contexts when studying acculturation.
Can PROMIS domains of pain and physical functioning detect changes in health over time for children with sickle cell disease?

Field: Medicine (Health Sciences)

Abstract Background The Patient‐Reported Outcomes Measurement Information System (PROMIS) includes multiple domains that measure pain and physical functioning which are valid and reliable for use in children with sickle cell disease. The responsiveness of these measures to detect changes in health status over time among children with sickle cell disease is unknown. Procedure We conducted a prospective cohort study of children presenting to emergency department (ED) with vaso‐occlusive crises. Children completed PROMIS surveys in the ED and at two follow‐up time points (7‐10 days and 1‐3 months) after their acute care visit. Linear mixed models were used to determine if there were significant changes in PROMIS T scores over time. We used a patient's global assessment of change in pain question to anchor the changes in PROMIS scores (mean and 95% confidence interval). A change was considered statistically significant if the 95% CI did not include 0. Results We found that patients improved significantly in all domains 1 to 3 months after discharge from an acute care visit for pain. In addition, the pain and physical stress experience domains were responsive to change 7 to 10 days after discharge. Using the anchor of change in pain, for children who had considerable improvement in pain, there were significant changes in PROMIS T scores ranging from 6 to 15. Conclusions Relevant PROMIS domains detect changes in children experiencing acute vaso‐occlusive crises. These domains can be used in research and clinic settings to measure clinically relevant change in children with sickle cell disease.
Trade Openness and Manufacturing Sector Performance in Nigeria

Field: Economics, Econometrics and Finance (Social Sciences)

How important is trade openness as a vehicle for driving productivity in developing countries? We offer a sector-specific analysis with focus on the manufacturing sector for meaningful policy insights. Using a modern econometric technique—the autoregressive distributed lag approach to cointegration—this article attempts to establish the relationship between openness to trade and manufacturing performance in Nigeria for the period 1970–2008. The results suggest that trade openness has a significant positive impact on manufacturing productivity in Nigeria both in the short and long run. These coefficient estimates are robust and stable over the time. Therefore, the policy direction for the manufacturing sector in Nigeria should focus more on open policies through trade liberalisation as a long-term plan. Reduction in trade restrictions and implementation of appropriate incentives are vital for resuscitating the performance of the sector. In this aspect, policy-makers should leverage the benefits of openness to the comparative advantages in the liberalised sector. JEL Classification: F41, C22, O55
Investigating the Effectiveness of Play in Easing Daily Home- To- School-Transition Process for Nursery Pupils at UDS-Early Childhood Centre

Field: Social Sciences (Social Sciences)

This study investigated the effectiveness of play in easing the daily home to the school transition process for nursery pupils at University for Development Studies-Early Childhood Centre. The study employed a mixed design approach (qualitative and quantitative designs) to identify vital aspects of the process in helping to improve the daily home-to-school transition process for children. Ten children participated in the study for a period of two weeks. The children were observed, and their data recorded from 7am to 8am each morning. Informal interviews with ten (10) parents, five (5) teachers and two (2) administrators were conducted to find out more about children's home-to-school transition behaviour. The quantitative analysis was done with the use of SPSS and thematic analysis for qualitative data. It was concluded that: play is effective in smoothening children's transition, separation anxiety was the primary factor that caused poor transition, and that the use of play in school transition is obstructed by rigid school routines, inadequate play equipment and toys and teachers' attitude. It is therefore recommended that teachers and administrators should make provisions to allow children some time to play upon arrival at school before lessons begin, strategies such as window hugging and many others should also be employed to reduce the distress of separating children from their parents upon arrival to school in the morning.
Boosting European market access to Malian mango growers

Field: Business, Management and Accounting (Social Sciences)

FRUILEMA, a Malian fruit and vegetable economic interest group (EIG), is acquiring the tools and resources needed to meet the requirements (GLOBALGAP certification) for exporting Malian farm products to international markets. Starting with the highly marketable mango fruit, an ICT solution has been developed to enable the identification of producers, to trace farm plots and produce, and to obtain quantitative and qualitative information on produce to support analysis and decision-making. The information is accessible via a web-enabled platform and can be updated using Internet and PDAs. The information is disseminated to producers, trackers, collectors, importers, and other actors in the mango value chain.
Upregulated SLC1A5 promotes cell growth and survival in colorectal cancer.

Field: Medicine (Health Sciences)

Glutamine metabolism is essential for tumorigenesis of colorectal cancer, cancer cells remodel their glutamine metabolic pathways to fuel rapid proliferation. SLC1A5 is an important transporter of glutamine various cancer cells. In this study, we investigated SLC1A5 protein expression in colorectal cancer and evaluated its clinical significance and functional importance. Immunohistochemical analysis was performed on tissue microarrays containing 90 pairs of cancer and adjacent normal tissues from colorectal cancer patients, we found that SLC1A5 expression increased significantly in colorectal cancer compared with normal mucosa tissues (P < 0.001). We further validated SLC1A5 overexpression in 12 pairs of fresh cancer and adjacent normal mucosa tissues from colorectal cancer patients by Western blot (P < 0.05). SLC1A5 expression levels were strongly associated with T stage of tumor (P < 0.05), and the tubular adenocarcinoma subtype (P < 0.001). Moreover, downregulation of SLC1A5 by synthetic siRNA could suppress proliferation and induce apoptosis in colorectal cancer cell lines HT29 and HCT116. In conclusion, our results provide for the first time the differential expression in human colorectal cancer and normal tissues, and a functional link between SLC1A5 expression and growth and survival of colorectal cancer, making it an attractive target in colorectal cancer treatment.