jimnoneill/paper-to-field-training huggingface dataset:
The Learning Object Economy: Implications For Developing Faculty Expertise

Field: Social Sciences (Social Sciences)

The evolving use of learning technologies and systems, such as learning object systems, to support more social learning environments in which learners have more agency than ever before to construct their own learning experiences is an innovation that involves both faculty and learners in a process of difficult sociocultural change. Programs of faculty support that acknowledge that faculty’s learning needs extend beyond the development of technical skills to the development of new pedagogical skills are indicated. This paper argues that the evolving concept of learning objects systems, and the "economy" that is emerging around the idea of sharable, reusable learning objects managed by repositories, presents new challenges and opportunities for our community. Faculty working with these systems may need to be supported through a personal process of reconceptualizing the nature of teaching and learning within these environments. This process of personal transformation has the potential for change in institutional policy and practice, the institutional cultural change of which Tony Bates (2000) and others speak (cf. Advisory Committee for Online Learning, 2000). The Collaboration for Online Higher Education Research (COHERE) is an alliance of eight research-intensive Canadian universities that is examining these challenges through a multi-pronged research program, one focus of which is supporting faculty as they research their own practice related to technology-enhanced teaching innovations. More specifically, this paper is itself a collaboration among the COHERE partners to share our collective belief about the potential for faculty and institutional transformation through participation in these "e-learning evolutions".
Visibility of a moving segment observer

Field: Mathematics (Physical Sciences)

In this paper we study combinatorial segment visibility, and show how to compute and maintain it as the observer moves in the plane. There are n non-overlapping convex objects in the plane, and we have a segment observer among them. We first consider static case of the problem, in which the observer and objects are static, and then we study dynamic case of the problem, in which the observer can move among obstacles.
GENAVOS: A New Tool for Modelling and Analyzing Cancer Gene Regulatory Networks Using Delayed Nonlinear Variable Order Fractional System

Field: Computer Science (Physical Sciences)

Gene regulatory networks (GRN) are one of the etiologies associated with cancer. Their dysregulation can be associated with cancer formation and asymmetric cellular functions in cancer stem cells, leading to disease persistence and resistance to treatment. Systems that model the complex dynamics of these networks along with adapting to partially known real omics data are closer to reality and may be useful to understand the mechanisms underlying neoplastic phenomena. In this paper, for the first time, modelling of GRNs is performed using delayed nonlinear variable order fractional (VOF) systems in the state space by a new tool called GENAVOS. Although the tool uses gene expression time series data to identify and optimize system parameters, it also models possible epigenetic signals, and the results show that the nonlinear VOF systems have very good flexibility in adapting to real data. We found that GRNs in cancer cells actually have a larger delay parameter than in normal cells. It is also possible to create weak chaotic, periodic, and quasi-periodic oscillations by changing the parameters. Chaos can be associated with the onset of cancer. Our findings indicate a profound effect of time-varying orders on these networks, which may be related to a type of cellular epigenetic memory. By changing the delay parameter and the variable order functions (possible epigenetics signals) for a normal cell system, its behaviour becomes quite similar to the behaviour of a cancer cell. This work confirms the effective role of the miR-17-92 cluster as an epigenetic factor in the cancer cell cycle.
REFERENCES

Field: Medicine (Health Sciences)

the CON group vs. the RUP group. The CC genotype was signif-icantly over-represented (p = 0.019) in the CON group (24%) compared to the RUP group (3%). Inferred haplotype analyses showed no significant difference in the frequency distributions of the VEGFA or KDR haplotype combinations between the CON vs. TEN groups or the CON vs. RUP groups. Discussion This pilot study did not find a statistical association with any of the five tested polymorphisms within the VEGFA and KDR genes using the Achilles tendinopathy risk model. However, the preliminary results are suggesting that the VEGFA rs699947 polymorphism may be implicated in acute injuries as noted in the Achilles tendon rupture cases. This hypothesis would be in alignment with the previous ACL risk model obser-vations [Rahim, 2014]. These loci therefore need further inter-rogation in larger sample sizes. Studies are underway to explore the five polymorphisms within two independent case-control samples sets, in order to elucidate the potential biologi-cal significance of the angiogenesis-associated cell signalling pathway in the aetiology of Achilles tendon injuries (overuse and acute).
Demonstration of G-quadruplex-assisted hybridization chain reaction for nucleic acid detection

Field: Chemistry (Physical Sciences)

In recent years, the hybridization chain reaction (HCR) has been proposed as an alternative to polymerase chain reaction (PCR) for diagnosis. Unfortunately, the sensitivity of the HCR methods are still far below PCR and researchers focus on ways to improve it by investigating different HCR designs. While earlier designs exploit fluorescently labelled probes for detection, here we propose an HCR system that combines G-quadruplex formation and fluorescence for detection of single stranded DNA sequences with concentrations as low as 20 pM. We show that G-quadruplex-mediated oxidation of Amplex Red results in fluorescence increase and lowers the detection limit by about 10fold, in comparison to HCR using only fluorescently labelled HCR probes.
P-574 Anti-Müllerian hormone: A novel marker for ovarian torsion?

Field: Medicine (Health Sciences)

Abstract Study question Can measuring plasma AMH levels assist in diagnosing ovarian torsion? Summary answer AMH levels show fluctuations during the acute phase of ovarian torsion, potentially aiding in clinical diagnosis. What is known already Anti-Müllerian Hormone (AMH), a measure of the ovarian follicular reserve, might fluctuate upon ovarian ischemia as per the “burnout theory,” where ovarian ischemia triggers primordial follicle recruitment and increased follicular growth. Accordingly, ultrasound indicators of ovarian torsion include the presence of small follicles at the ovarian periphery. Our hypothesis suggests that ovarian ischemia from torsion could alter serum AMH levels, offering diagnostic value. Study design, size, duration A prospective observational study was conducted in a single tertiary care center between 2021-2023. The study analyzed serum AMH levels in 17 patients aged 12-45 admitted with acute abdominal pain and undergoing diagnostic laparoscopy due to suspected ovarian torsion. Patients with AMH levels below the 5th percentile were excluded. Participants/materials, setting, methods Patients with suspected ovarian torsion underwent diagnostic laparoscopy based on clinical and sonographic criteria. Peripheral blood samples collected upon admission and on the first postoperative day were used to measure plasma AMH levels. AMH levels were compared between patients with confirmed ovarian torsion and those without this diagnosis. Main results and the role of chance Demographic characteristics were similar between the groups. Patients diagnosed with ovarian torsion showed higher pre- and postoperative AMH levels than those without torsion (4.33∓1.58 vs. 2.8∓1.28 ng/ml, p = 0.08 and 4.16∓1.52 vs. 2.71∓1.3 ng/ml, p = 0.09, respectively), but these differences were not statistically significant. However, the change in AMH levels from pre- to postoperative was more significant in patients with ovarian torsion compared to those without (0.66∓0.34 vs. 0.21∓0.18, p = 0.01). Limitations, reasons for caution • Small study size • High variability in basal AMH levels in women of reproductive age Wider implications of the findings These results suggest that ovarian ischemia might influence AMH secretion, potentially serving as part of diagnostic evaluations. Ongoing studies aim to validate AMH as a biomarker for ovarian torsion, aiming to reduce unnecessary surgeries, lower patient risks, and minimize healthcare costs. Trial registration number 0151-21-RMB
VERBALIZATION OF THE CONCEPT ALCHEMY IN THE ENGLISH LANGUAGE AND SPEECH

Field: Arts and Humanities (Social Sciences)

The article is dedicated to the study of the concept verbalization and the definition of its conceptual features, which is one of the relevant tasks of linguoconceptology. The purpose of the article is to analyze the lexical means of verbalizing the concept ALCHEMY as part of the English hyperconcept OCCULTISM. The analysis was based on explanatory, etymological dictionaries of the English language, scientific and publicist texts on the Internet, which are devoted to the description of English occultism. The following research methods are used in the work: etymological analysis, definition analysis, conceptual analysis, contextual-interpretative method. The article contains the definition of the term “concept” as an operational meaningful unit of memory, mental lexicon, conceptual system and brain language (lingua mentalis), the whole worldview reflected in the human psyche, provides basic approaches to its study and structure. In this study, an attempt is made to take into account different approaches to structuring the concept, in particular, the linguistic and cultural concept. The following thesis is important: the structure of the concept must reflect the initial people’s perception of the phenomenon, its understanding at the conceptual level, as well as other ideas about it that arise as a result of continuous human interaction with the outside world. We believe that motivational and notional features are primary or basic, other features are secondary and may vary in their number and methods of nomination. The definition and contextual-interpretative analysis showed that the notional features of the concept ALCHEMY are “unscientific, search, transformation, eternal life, universal medicine, mysticism, secrecy, purity of thought, durability”. The motivational features of the concept ALCHEMY are determined by the etymology of the English lexical unit “alchemy” and are verbalized as follows: “occultism, search, unscientific”. A promising continuation of this study is the analysis of lexical means of verbalization of the concept ASTROLOGY as part of the English hyperconcept OCCULTISM in language and speech.
The nature and the content of a logistical approach to reducing food wastage

Field: Business, Management and Accounting (Social Sciences)

Subject. Food security is an integral part of the state welfare. Improving the provision of food to the population is a pressing social and economic problem. Accounting and control of agricultural losses and food waste is one of the most significant components of the country's sustainable development. In the current context, it has become increasingly important to identify the prerequisites for the development of a logistical approach to reducing food wastage. Objectives. The development of the main principles of a logistical approach to reducing food wastage and their characteristics. Methods. The research was conducted with the help of a systematic approach and statistical and theoretical research methods. The authors also used the information resources of Rosstat databases and federal and regional normative and legal documents. Scientific literature by Russian and international authors was studied and an analysis of the research and practical materials was made. Results. The application of a logistical approach during the stage of production, processing, marketing, and utilisation of foodstuffs will enable meeting on a high level the food needs of the population without unnecessary losses and spoilage. Conclusions. Logistics as a new concept of managing material and related financial and information flows is becoming increasingly popular in agroindustrial industries. The logistical tools are particularly efficient for procurement and distribution of end products. The provision of resources for farmers and the promotion of their products on the market based on the principles of logistics have significant economic, social, and environmental benefits. One of the most effective tools for reducing losses and the spoilage of foodstuffs, and thus providing a better service for the end uses, is logistics management.
Pressure in the Southern Hemisphere

Field: Earth and Planetary Sciences (Physical Sciences)

The general distribution of mean pressure at sea level over the Southern Hemisphere has been known since Buchan's maps were published in 1869. Many others have since appeared, the best known of which are those in Hann's textbook (1901), and in Shaw's Manual of Meteorology (1927). Meinardus and Mecking (1911b) combined a series of daily synoptic maps (1 October 1901–31 March 1904) into monthly mean pressure maps of much of the area south of 305, which are still very valuable because of the careful analysis and of the many ships' observations then, where few, if any, are taken now. Meinardus (1928, 1929) used this series in a study of the pressure which is instructive and unsurpassed, but often ignored. Pressure in the Southern Hemisphere has also been treated by Spitaler (1901), Reuter (1936), Wahl (1942), Gordon (1953), Vowinckel (1955), Schwerdtfeger and Prohaska (1956), Hofmeyr (1957a), van Loon (1961), and Pflugbeil (1967).
Study on milling technology of hempseed milk

Field: Agricultural and Biological Sciences (Life Sciences)

The soaking and pulping processing of hempseed milk were studied using single factor and orthogonal experiment. The optimum technological conditions were:roast time 10min,roast temperature 70℃,soak time 1. 5h,soak temperature 30℃,pulping time 6min,pulping temperature 70℃,pulping pH 7. 5,rate of hempseed and water 1∶ 12,under this condition dissolution rate of hempseed protein was 78. 4492%,protein content of hempseed milk was 2. 6639%.
DETECTION OF CLONALLY EXPANDED SALIVARY GLAND LYMPHOCYTES IN SJÖGREN'S SYNDROME

Field: Medicine (Health Sciences)

Recurrent swelling of the parotid and submandibular salivary glands occurs in some patients with Sjögren's syndrome (SS). Using Southern blot methods, we analyzed immunoglobulin and T cell antigen receptor (TCAR) gene rearrangements in DNA obtained from salivary gland lymphocytes of 9 SS patients. Based on histologic appearance of the biopsy specimens, these patients were diagnosed as having myoepithelial sialadenitis. We found oligoclonal rearrangements of the κ gene (4 patients) and λ gene (1 patient), and oligoclonal rearrangement of the TCAR β chain in 2 additional SS patients. Patients with Ig gene rearrangements did not show rearrangements of their TCAR gene, nor did patients with TCAR rearrangements exhibit Ig rearrangements. The observed oligoclonal rearrangements probably derive from 5‐10% of the salivary gland B cells or T cells. Three of these SS patients developed non‐Hodgkin's lymphoma 2‐8 years after the initial biopsy. Our results suggest that minor populations of B cells or T cells may clonally expand in the salivary gland tissues of SS patients with pseudolymphoma, and that such lymphocyte expansions may be controlled by the endogenous immune response and/or medications. However, continued lymphoproliferation in these salivary gland tissues may eventually lead to emergence of a neoplastic clone that escapes immunologic control and develops into a non‐Hodgkin's lymphoma as a result of a multistep process.
Prediction of adult asthma-risk in early childhood using novel Adult aSthma PredIctive Risk scorEs (ASPIRE)

Field: Medicine (Health Sciences)

Aims and Objectives: Numerous risk scores have been developed to predict childhood asthma. However, they may not predict asthma beyond childhood. We aim to create childhood risk scores that predict development and persistence of asthma up to young adult life. Methods: The Isle of Wight Birth Cohort (n=1456) was prospectively assessed up to 26-years of age. Asthma predictive scores were developed based on factors during the first 4-years, using logistic regression and tested for sensitivity, specificity, and area under the curve (AUC) for prediction of asthma at (i) 18 and (ii) 26-years, and persistent asthma (PA) (iii) at 10 and 18 years, and (iv) at 10, 18 and 26 years. Models were internally and externally validated. Results: Four models were generated for prediction of each asthma outcome. ASthma PredIctive Risk scorE (ASPIRE)-1: a 2-factor model (recurrent wheeze [RW] and positive skin prick test [+SPT] at 4-years) predicted asthma at 18-years (sensitivity: 0.49, specificity: 0.80, AUC: 0.65). ASPIRE-2: a 3-factor model (RW, +SPT and maternal rhinitis) predicted asthma at 26-years (sensitivity: 0.60, specificity: 0.79, AUC: 0.73). ASPIRE-3: a 3-factor model (RW, +SPT and eczema at 4-years) predicted PA-18 (sensitivity: 0.63, specificity: 0.87, AUC: 0.77). ASPIRE-4: a 3-factor model (RW, +SPT at 4-years and recurrent chest infection at 2-years) predicted PA-26 (sensitivity: 0.68, specificity: 0.87, AUC: 0.80). ASPIRE-1 and ASPIRE-3 scores were replicated externally. Further assessments indicated that ASPIRE-1, a 2-factor model (RW and +SPT) can be applied to predict all 4 asthma outcomes. Conclusion: ASPIRE predicts persistent asthma up to young adult life.
Competencies for virtual teamwork: Developmentand validation of a web-based selection tool for members of distributed teams

Field: Psychology (Social Sciences)

The development and validation of the Virtual Team Competency Inventory (VTCI), an Internet-based measure for selection and placement of members in virtual teams, is described. Item selection was based on a conceptual model with three main categories (taskwork, teamwork, and telecooperation related KSAs) and 11 subscales. After an exploratory pilot study with 169 undergraduate students, 39 items remained in the final version of the VTCI. In the main study, 258 members of organizational virtual teams completed the VTCI and were concurrently assessed by their team managers. The results showed satisfactory reliability of the VTCI (overall alpha = .92) and good convergent and discriminant validity. The concurrent multiple validity of the VTCI was .49 for individual team members' performance. Moreover, analyses at the team-level revealed significant correlations between team effectiveness and mean, minimum (but not maximum), and variance aggregations of VTCI predictors within the teams.
Watershed Management Policies and Programs in Bhutan

Field: Environmental Science (Physical Sciences)

This chapter provides discussion and debate on identifying the best possible ways to manage water resources in Bhutan by placing the farming communities at the centre of water resources development. It describes the concepts of Gross National Happiness as the overall framework to assess the possible outcome of standing water resources policies and programs. It provides debate on the formulation of water resource governance policies so that the outcome is relevant to the Bhutanese people. The main reason for farmers having limited capacity to use water resources is the lack of infrastructural facilities like irrigation channels to bring water from where it is available to where it is required and water storage mechanism which can help store water when it is available and use it when it is required. The existing consumption pattern suggests that farmers evidently have not benefited directly from state investments in hydropower development.
Cancer Biopsy in Ancient Persian Medicine: Do or Not to Do!

Field: Medicine (Health Sciences)

Dear Editor-in-ChiefOne of the controversial topics in cancer research and its clinical approach is the influence of biopsy on the possibility of tumor spread and metastasis that seems to be a new issue in medical knowledge (1-2), but Avicenna in more than a thousand years ago (980-1037 AD) in his book (Cannon of medicine) has been connoting on this subject (3).According to the Avicenna opinion, cancer is described as a solid (tumor) which is firmly attached to the adjacent organ (4). In this point of view, being susceptible to cancer depends on quality of life such as nutrition, physical activity etc. (3, 4). The other risk factor on which Avicenna emphasized is past history of injury and trauma, damage and chronic or severe pain in different parts of the body. He believed that pain and trauma absorbs substances including natural and toxic materials from the other parts of body to the pain point that can start genesis of cancer. Traumas moreover can damage self-layer of swelling in cancerous tissue, and disperse disease locally or generally in body (3, 4).Nowadays multiple continuing traumas in the same region of the body (skin or oral mucosa) is a known cause of cancer (5). Chronic inflammation is a precursor factor of tumor progression and many cancers have been found to occur from location of infection, chronic irritation, and inflammation (6, 7). Trauma induces tumor immunosuppressive factors that increase vascular permeability and facilitating passage of the tumor cells into the other tissues (8).Moreover, some studies even showed the relationship between single trauma and cancer development. It can also lead to a significant increase in tumor size over a short duration times (8). Indeed traumatizing the cancer tissue leads to trigger inflammation process that allows cells to progress by proliferation, survival, and migration (9).Based on this theory, Avicenna and his followers forbade physicians from manipulation without complete removal of tumors. They stated: tranquilize the tumor, do not stimulate it, so they used medicinal herbs like Viola Odorata L. (banafshe), Nymphea Alba L. (niloofar) and Cucurbita pepo to calm tumors cells. Some new studies have been shown effects of such herbs on inhibition of cancer cell growth (3, 4). Therefore, it seems that the use of the herbs before biopsy will reduce the chances of potential tumor spreading (10).According to Avicenna's recommendation in more than thousand years ago, we propose the use of non-invasive methods such as laboratory parameters and biomarkers, for tumor detection; although the effect of biopsy in cancer metastases is not conclusive. We also suggest further investigation on also the influence of herbal drugs such as syrup of violets for tumor cells tranquilizing before the biopsyAcknowledgmentThis comment is based on PhD thesis number 58, school of Traditional Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran. …