jimnoneill/paper-to-field-training huggingface dataset:
777-P: Short-Term Continuous Subcutaneous Insulin Infusion Treatment Improves Peripheral Autonomic Neuropathy in Type 2 Diabetes

Field: Medicine (Health Sciences)

Background: Short-term continuous subcutaneous insulin infusion treatment (CSII) in patients with newly diagnosed type 2 diabetes (T2DM) can improve β-cell function and insulin sensitivity, which results in long-term remission. However, the effect of CSII on peripheral neuropathy is rarely studied. Methods: 63 T2DM patients (HbA1c&gt;9%) were hospitalized and treated with CSII for 2 weeks. Peripheral autonomic neuropathy was measured by SUDOSCAN, which provides an age adjusted electrochemical skin conductance (ESC) composite score incorporating hands/feet ESC measurements, with a score ≤60 indicating sudomotor dysfunction. Blood glucose, HbA1c, C-peptide and SUDOSCAN were measured before and after CSII. HOMA-B was used for assessment of β-cell function. Results: The average HbA1c of included patients was 10.5% with median duration of T2DM was 3.5 years. There were 27 (42.9%) patients who had sudomotor dysfunction at baseline. After 2 weeks of CSII, the proportion of sudomotor dysfunction (42.9% vs. 31.7%, P=0.020) was significantly deceased along with significantly improved HbA1c (10.0±1.9 vs. 8.1±1.0, P&lt;0.001) and HOMA-B [22.0 (IQR 12.1-37.0) vs. 56.9 (IQR 42.4-81.8) , P&lt;0.001]. Correlation analysis revealed that higher ESC composite score was correlated with better HOMA-B after CSII (r=0.445, P=0.015) . Conclusion: Peripheral autonomic neuropathy could be improved by CSII in T2DM. The improvement of β-cell function could be responsible for the amelioration of peripheral nerve function. Keywords: Short-term continuous subcutaneous insulin infusion treatment; peripheral autonomic neuropathy; type 2 diabetes; β-cell function Disclosure J.Jin:None. Funding National Key R&D Program of China (2018YFC1314100) ; the Key-Area Research and Development Program ofGuangdong Province (2019B020230001) ; the China Postdoctoral ScienceFoundation (2018M640871)
Validation and psychometric evaluation of the Polish version of the Exercise Addiction Inventory (EAI-PL)

Field: Psychology (Social Sciences)

Background Exercise addiction (EA) is manifested by loss of control over exercising and experiencing numerous negative consequences. One of the most commonly used psychometric instruments to assess the risk of exercise addiction is the six-item Exercise Addiction Inventory (EAI). The present study translated and validated the EAI into Polish and evaluated its psychometric properties. Participants and procedure The study included 858 adult participants (54% female) aged between 18 and 69 years (M = 35.20, SD = 9.54) who exercised recreationally. Participants completed the EAI along with exercise-specific questions and basic demographics. Additionally, a subsample (n = 214) completed the Exercise Dependence Scale-Revised. Confirmatory factor analysis (CFA) was conducted to assess the construct validity of the Polish EAI. Convergent and criterion validity, as well as reliability, were also assessed. Results The CFA confirmed the one-factor model with good fit statistics (comparative fit index and Tucker-Lewis index > .95, root-mean square error of approximation < .08). The EAI was invariant between men and women. Convergent validity was ade-quate. The scale’s internal consistency was excellent (Cronbach’s α = .91, McDonald’s ω = .91, and composite reliabil-ity = .91). Conclusions The present study successfully validated the EAI among Polish adults. The results provide robust evidence concerning the scale’s reliability, construct validity, and convergent validity, enabling further research on exercise addiction in Poland.
A Substitute Presumptive Test for Screening of Semen using Sodium –p– Nitrophenyl Phosphate (NaPNPP)

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract

BackgroundIn forensic investigation of alleged sexual crimes, presumptive semen detection test methods are commonly used to reach preliminary identification of seminal fluid in questioned samples. These methods are based on the detection of components of semen such as enzyme acid phosphatase (AP). Of these methods, the acid phosphatase identification method still remains the most reliable and widely used presumptive test due to high activity of the AP in seminal fluid. In standard AP test, Bretamine Fast Blue B (FBB) reagent is used. However FBB has been explicitly classified as carcinogenic. Although FBB has been handled safely over time, there is a need at the moment to develop a simple, readily available, reliable and efficient method for screening the presence of semen in any material collected as evidence in a sexual assault crime.Given the improved sensitivity of DNA profiling tests that have been introduced in to routine forensic casework over recent years, the need for improved sensitivity at this first stage of detection has never been higher. FindingsHere we highlight a simple method using readily available reagents in standard biochemical laboratory as a substitute for the standard AP test for seminal fluid identification from a crime scene. This method is based on the hydrolysis of sodium–p-nitrophenyl phosphate at pH 5.5 by the acid phosphatase to produce an intense yellow coloured complex in 15 seconds. ConclusionsThe method presented is sensitive, reliable, efficient and routinely used in standard biochemical and pathology laboratories for spectrophotometric analysis of alkaline phosphatase. It can be easily and readily applied as a preliminary test for identification of semen at a crime scene that involves sexual assault.
Efektivitas Model Project Based Learning Pada Mata Kuliah Vulkanologi Terhadap Hasil Belajar Mahasiswa

Field: Social Sciences (Social Sciences)

This study aims to determine the effectiveness of learning using the Project-Based Learning (PjBL) Model or project-based learning on student learning outcomes in volcanology courses. This study used a quasi-experimental design with a Nonequivalent (Pretest-Posttest) Control Group Design. The study population was all students who contracted the Volcanology course in the Physics Study Program of the Faculty of Mathematics and Natural Sciences UNIMA for the 2019-2020 Odd Academic Year. The sample used the purposive sampling technique and divided the experimental class and the control class. The research data were collected using a test instrument for the comprehension ability of the material. The results showed that the average student learning outcomes in the experimental class were 89.74%, higher than the control class 72.11%. The results of statistical test analysis, namely t-test, obtained the value of t count 3.80 greater than t table, namely 2.10 with a real level α = 0.05, which means that the effectiveness of project-based learning models (Project Based Learning) on learning outcomes students are better than conventional learning models.
FCRL4 Is an Fc Receptor for Systemic IgA, but Not Mucosal Secretory IgA

Field: Immunology and Microbiology (Life Sciences)

Abstract Fc receptor–like (FCRL) 4 is an immunoregulatory receptor expressed on a subpopulation of human memory B cells of mucosa-associated lymphoid tissue. Fc receptor function of FCRL4 was demonstrated by binding of IgA to FCRL4 following heat aggregation of the Ig. In this study, we demonstrate that FCRL4 recognizes J chain–linked systemic IgA in the absence of heat aggregation. We further demonstrate that mucosal secretory IgA is not recognized by FCRL4 and that systemic IgA binding can be competitively inhibited by recombinant secretory component protein. Finally, we provide evidence that primary FCRL4-bearing human memory B cells are constitutively bound to IgA. Our study provides a mechanism for the negative regulatory activity of FCRL4 on AgR-mediated B cell activation.
The Aggregate Model

Field: Mathematics (Physical Sciences)

Abstract Just as in Part I, by letting the size of the population grow, under suitable assumptions on the micro model, the variance ratio of the common to the idiosyncratic component can be made bigger than any preassigned real number. The following condition reproduces Assumptions 1.1 and 1.2 for the micro model underlying the aggregate model. Notice that here, unlike in Assumption 1.2, we impose the second condition on the whole r. But this is obviously necessary since the condition is not on the populations but on the set from where the individuals of the populations are picked up. If the second condition did not hold for the whole r, we could form populations for which the idiosyncratic component would not vanish.
Calcium Chloride Hexahydrate/Diatomite/Paraffin as Composite Shape-Stabilized Phase-Change Material for Thermal Energy Storage

Field: Materials Science (Physical Sciences)

In this work, the calcium chloride hexahydrate/diatomite/paraffin composite phase-change material (PCM) was fabricated by impregnating calcium chloride hexahydrate into diatomite and further coating with paraffin. Scanning electron microscope (SEM) results showed that the hydrated salt could be impregnated into a diatomite well and the paraffin could be coated on a diatomite surface. The Fourier transform infrared spectroscopy (FT–IR) demonstrated that no chemical interactions were found between calcium chloride hexahydrate and diatomite matrix except that of hydrogen bonds. The melting and crystallizing enthalpy of the coated composite PCM are 108.2 and 98.5 J/g, respectively. The supercooling of hydrated salts was weakened due to the nucleation positions on the huge surface of diatomite and the coating effect of the paraffin, and phase segregation was eliminated in 100 cycles by microvolume effect in the pores of the diatomite. Additionally, coated composite PCM and composite PCM exhibited better thermal stability and reliability than hydrated salts due to the interactions of hydrated bonds, the capillary force and the surface tension as well as the coating of the paraffin. After the 100 cycles, the melting and crystallizing enthalpy of coated composite PCM declined to 106.2 and 93.8 J/g from 108.2 and 98.5 J/g, dropping by 1.8% and 4.8%, respectively. The coated composite PCM with well thermal properties, thermal reliability, and chemical stability was a promising PCM candidate for heat-energy storage applications.
Small and large size for gestational age at birth, infant growth, and childhood overweight

Field: Medicine (Health Sciences)

Children born small, appropriate and large size for gestational age have different growth patterns in early childhood and persistent differences in their head circumference, length, and weight until the age of 4 years. Children born with an appropriate weight for gestational age with catch-up growth and large weight for gestational children without catch-down growth have an increased risk of overweight.
The new approaches on sustainable wildlife of Amik Lake.

Field: Environmental Science (Physical Sciences)

Turkey has been on a crucial routes of the migrating birds. These birds have been coming from Istanbul-Camlica hills and through Artvin-Borcka to the homeland. And the migrating birds turn to the Africa continent over Syria by passing Hatay-Belen. During the mmigration, the birds use the location of Amik Lake as a watery land for temporary settlement. The Amik Lake which should have been protected as a watery land for birds according to Ramsar Agreement that Turkey signed, was caused to dry ten years ago. There weren't only negative effects on the wildlife by drying but also soil degraded and productivity decreased though the aim was to improve agriculture and contributions to local developments on the Amik Lake dry land. During the last two decades, it was known that one of the birds, which is called Anhinga rufa extincted as a cause of drying ot Amik Lake. In this study, some results that emerged as a cause of drying of Amik Lake were presented.
Analysis of the accuracy-latency-energy tradeoff for wireless embedded camera networks

Field: Computer Science (Physical Sciences)

Wireless embedded smart cameras provide flexibility in camera deployment in terms of the locations and number of the cameras. However, these battery-powered embedded vision sensors have very limited energy, memory, and processing power. Energy consumption and latency are two major concerns in wireless embedded camera networks. In multi-camera tracking applications, the amount of data exchanged between cameras has an effect on the tracking accuracy, the energy consumption of the camera nodes and the latency. In this paper, we provide a detailed quantitative analysis of the accuracy-latency-energy tradeoff for overlapping and non-overlapping camera setups when different-sized data packets are transferred in a wireless manner. The experiments have been performed with an actual wireless embedded smart camera network employing CITRIC motes, and performing tracking of objects.
A phase I study of vorinostat in combination with bortezomib in refractory solid tumors

Field: Medicine (Health Sciences)

3573 Background: Vorinostat (suberoylanilide hydroxamic acid, SAHA) is a histone deacetylase (HDAC) inhibitor that has anti- tumor activity in hematologic malignancies and advanced solid tumors. Based on studies showing that HDAC inhibitors increase the activity of the 26S proteasome, vorinostat has been postulated to act synergistically with bortezomib. This study was conducted to determine the toxicities and efficacy of vorinostat with bortezomib. Correlative studies included pharmacokinetics and the effects of vorinostat/bortezomib on cell cycle, proteasome inhibition, histone acetylation, gene expression and apoptosis. Methods: This study used standard eligibility criteria except pts must have had no prior bortezomib. The treatment plan consisted of vorinostat given orally on days 1–14 with bortezomib IV on days 1, 4, 8 and 11 of a 21-day cycle. Starting dose (Step A, level 1) was once-daily vorinostat (400 mg) and bortezomib (0.7 mg/m 2 ). Step B consisted of twice-daily dosing of vorinostat (200mg) with bortezomib at MTD established in Step A. RECIST was used to measure response. Effects on G2/M-phase arrest in buccal mucosa cells (BMC) were measured using flow cytometry. Samples were collected on days 1 and 9, at 0, 2 and 4 hr following treatment. Results: 22 pts have been enrolled; 14 men, 8 women. Tumor types: 5 sarcoma, 5 colorectal, 3 pancreatic, 2 lung, 1 breast, 1 ovarian, 1 bladder, 1 gastric, 1 germ cell, 1 mesothelioma, 1 GIST. Grade 3–4 toxicities at least possibly related to vorinostat at any dose level were as follows: fatigue (3), n/v (1), thrombocytopenia (1), and hyponatremia (1). One pt was unevaluable. DLTs included fatigue (3), hyponatremia (1) and elevated ALT (1). The MTD for Step A was established at vorinostat 400mg daily and bortezomib 1.3 mg/m 2 . One pt with refractory soft tissue sarcoma had a PR > 9 mo. There was no effect on cell cycle arrest observed with vorinostat in BMCs. Conclusions: The MTD for Step A was established at vorinostat 400mg daily and bortezomib 1.3 mg/m 2 . Accrual continues at Step B, dose level 1. Subjective and objective evidence of clinical activity has been observed in pts with refractory solid tumors. (Supported by NCI grant UO1 CA062491, NCI SAIC contract 25XS097 and GCRC M01 RR03186.) No significant financial relationships to disclose.
[Effect of kontrikal on the dynamics of proteolytic system indices in postischemic toxemia].

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

It was shown in Wistar male rats that the development of tourniquet shock was followed by an increase of proteolytic activity in the blood by 3 times, activity of aspartate aminotransferase (AST) by 3 times, that of alanine aminotransferase (ALT) by 6 times, contents of urea and residual nitrogen by 2.5-3 times; level of alpha 1-protease inhibitor (alpha 1-PI) decreased by 4 times and that of alpha 2-macroglobulin (alpha 2MG) by 2.5 times. At administration of contrykal (10,000 U/kg) proteolytic activity increased only by 32.5%, content of alpha 1-PI decreased only by 10-20% and level of alpha 2-MG did not differ from that in healthy animals. Activity of AST and ALT remained high, and contents of urea and residual nitrogen were near-normal.
Determination of amino acids in Vigna Minima by precolumn derivatization coupled with reversed-phase high performance liquid chromatography

Field: Chemistry (Physical Sciences)

To determine the composition and contents of amino acids in Vigna Minima by reversed-phase high performance liquid chromatographic(RP-HPLC) method,an ultimate amino acid column was used,and phenylisothiocyanate(PITC) was the precolumn derivatization agent. Elutions were carried out in a binary gradient mode. The column temperature was 40 ℃,and detection wavelength was set at 254 nm.The results show that: Totally 17 amino acids were found,the calibration curves of 17 amino acids all exhibited good linearity over the range from 1.2 to 250 μmol. and its precision,stability and repeatability were good,Mean recoveries for 17 amino acids were between 97.03% and 101.3%. with a relative standard deviation(RSD) between 0.63% and 1.9%(n=3),and the total content of amino acids in samples was 194.093~225.714 mg/g. So it has a very good foreground of development of edible. The order of the amino acid contents was GluTyrAspMetProArgPheLeuGlyLysAlaCysHisThrValSerIle. This method was simple,accurate and efficient,the measurement results are satisfactory,to provide a theoretical basis for the new resources Vigna Minima edible,medicinal etc.
Corporate Tax Avoidance and Corporate Social Responsibility Disclosure Readability: Evidence from China

Field: Business, Management and Accounting (Social Sciences)

Abstract Paying taxes to support the societies in which they operate is both a legal and ethical responsibility of business. Nevertheless, some companies work to avoid taxes, which could cause society to question the legitimacy of the organisation. Many companies provide reports on their corporate social responsibility (CSR) activities; more transparent CSR reports may help to restore the legitimacy loss associated with tax avoidance. We investigate the relationship between tax avoidance and CSR report readability among Chinese companies. We find a positive relationship between corporate tax avoidance and the readability of CSR reports. This relation is weaker among state‐owned enterprises, which may have stronger pre‐existing legitimacy owing to their relationship with the state. The relationship is also weaker among companies in less developed regions of China, which have less developed institutions to monitor organisational legitimacy. Overall, our results are consistent with the notion that CSR reporting represents an attempt to overcome legitimacy concerns arising from tax avoidance. Our findings indicate that tax avoidance and CSR reporting are alternative means of establishing legitimacy, rather than complementary reflections of an organisational culture that values (or devalues) CSR.
Original Article: An Evaluation of Community-Based Action Research Program for Medical Undergraduates in Rural Pondicherry

Field: Health Professions (Health Sciences)

Objective: To obtain the learners' reaction to a community-based action research program in a rural setting of Pondicherry. Methods: Both quantitative (post-then-pre rating) and qualitative (response to open ended questions) feedback from 125 medical students exposed to this program was obtained. Mean values were calculated for pre and post self-rating on skills acquired by the students in retro-pre feedback. The content analysis of the qualitative data was undertaken. Results: There was significant improvement in their perceived abilities to follow basic steps in carrying out research such as - problem identification, literature search, drafting a proposal, preparation of questionnaire, data collection, analysis and its reporting. Our approach could contribute to development of cognitive, social-emotional and vocational domains of the students. Conclusions: Overall, our community-based action research program is taking a shape and getting mainstreamed in the exiting curriculum. It could sensitize students to basic steps in research and contributed to their cognitive, social-emotional and vocational development. Further work is needed to increase its scope and intensity to achieve the development of cultural, moral and ethical domains.
Gastroenterological Surgery in Eight Schizophrenic Patients who Underwent Long-Term Administration of Antipsychotic Agents.

Field: Medicine (Health Sciences)

1992年から1994年末までの3年間に, 20年以上の長期にわたり抗精神病薬の内服治療を受けてきた8例の精神分裂病患者について消化器外科手術を経験した.手術の対象となった疾患は胆石症2例, 急性胆嚢炎2例, 虫垂炎の穿孔による汎発性腹膜炎2例, 肝内結石症と横行結腸癌が各1例であった. 術後の合併症は胆管空腸吻合の縫合不全と麻痺性イレウスを各1例に認めたのみで, 突然死例はなかった. 横行結腸癌で閉塞性イレウスをきたした1例を除いて, 抗精神病薬は手術の前日まで減量せずに継続した.手術の翌日から抗精神病薬の就眠前の非経口投与を開始し, 食餌開始にあわせて術前の経口剤を再開した. 4例に精神症状が見られたが, いずれも軽症で外科的管理上問題にならなかった. 精神分裂病患者の安全な周術期管理のためには精神科医の協力による精神的ケアが重要であった.
Exploring the Mediating Role of The Balance Use of the Performance Measurement System on the Relationship Between Intellectual Capital and Firm Performance

Field: Business, Management and Accounting (Social Sciences)

The purpose of this paper is to empirically explore how the balance use of performance measurement systems mediate the effects of intellectual capital dimensions including human, organizational and social capital on firm performance. The data were collected from a survey of 448 Vietnamese managers of Information and Communication Technology Sector and proposed hypotheses were tested by using partial least squares regression and a structural modeling technique which is appropriate for highly complex predictive models. Findings from hypotheses tests indicated that firms with higher level of intellectual capital dimensions place a premium on the balance use of performance measurement systems in a diagnostic and interactive style. Furthermore, the result also provides some evidences that Intellectual capital dimensions effect indirectly on firm performance through performance measurement systems.
Dictionary Learning for Gaussian Kernel Adaptive Filtering with Variablekernel Center and Width

Field: Computer Science (Physical Sciences)

This paper establishes an adaptive update method for the Gaussian kernel parameters in the application to the kernel adaptive filtering (KAF). In this method, the kernel parameters are all adaptive and data-driven, although they should be given or estimated by cross-validation. In terms of the Gaussian KAF, every input sample or signal has its own width and center, which are updated at each iteration based on the proposed least-square-type rules to minimize the estimation error. In particular, the proposed update rule keeps the width in the manifold of the positive numbers. Together with the l1- regularized least squares, the overall KAF algorithm can avoid the overfitting and the increase of dimensionality. Experimental results support the validity of the method.