jimnoneill/paper-to-field-training huggingface dataset:
Alternative splicing alterations of Ca2+ handling genes are associated with Ca2+ signal dysregulation in myotonic dystrophy type 1 (DM1) and type 2 (DM2) myotubes

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Aims The pathogenesis of myotonic dystrophy type 1 ( DM 1) and type 2 ( DM 2) has been related to the aberrant splicing of several genes, including those encoding for ryanodine receptor 1 ( RYR1 ), sarcoplasmatic/endoplasmatic Ca 2+ ‐ ATPase ( SERCA ) and α 1S subunit of voltage‐gated Ca 2+ channels ( Ca v 1.1 ). The aim of this study is to determine whether alterations of these genes are associated with changes in the regulation of intracellular Ca 2+ homeostasis and signalling. Methods We analysed the expression of RYR1 , SERCA and Ca v 1.1 and the intracellular Ca 2+ handling in cultured myotubes isolated from DM 1, DM 2 and control muscle biopsies by semiquantitative RT‐PCR and confocal Ca 2+ imaging respectively. Results (i) The alternative splicing of RYR1 , SERCA and Ca v 1.1 was more severely affected in DM 1 than in DM 2 myotubes; (ii) DM 1 myotubes exhibited higher resting intracellular Ca 2+ levels than DM 2; (iii) the amplitude of intracellular Ca 2+ transients induced by sustained membrane depolarization was higher in DM 1 myotubes than in controls, whereas DM 2 showed opposite behaviour; and (iv) in both DM myotubes, Ca 2+ release from sarcoplasmic reticulum through RYR1 was lower than in controls. Conclusion The aberrant splicing of RYR1 , SERCA1 and Ca v 1.1 may alter intracellular Ca 2+ signalling in DM 1 and DM 2 myotubes. The differing dysregulation of intracellular Ca 2+ handling in DM 1 and DM 2 may explain their distinct sarcolemmal hyperexcitabilities.
Investigation and development of high power inductors for power electronic applications

Field: Engineering (Physical Sciences)

Renewable energy has been the topic of interest and research in recent years, especially so in power electronics, because of the depletion of natural resources. Researchers around the world have been actively searching for possible alternative energy other than the traditional energy sources such as fossil fuels and coals. Possible forms of renewable energy are the wind energy from wind turbines or solar energy from solar panels. Passive components such as inductors are an important aspect in power converter. This final year project will be focusing on the investigation of different inductor cores and materials for high power output for applications and renewable energy. These different inductor cores will be connected to a IGBT switched dc-dc boost converter for comparison and data collection. For a fair experiment, the boost converter duty cycle and load will be fixed while the only variable component will be these inductors. These inductor cores are in the shape of toroid, E-core, U-core and laminated core and are coiled to an inductance value of 5mh at a frequency of 10 kHz. The wire coils are able to withstand 20 ampere current rating. This report also examines two different types of inductor materials, soft ferrite (Manganese-zinc ferrite) and iron-powdered.
CORONARY ARTERY CALCIFICATION: INTRACORONARY IMAGING, CONTEMPORARY TECHNOLOGIES OF TREATMENT

Field: Medicine (Health Sciences)

Highlights This review presents current state-of-the-art of diagnosis and treatment of coronary artery calcification. Abstract Coronary artery calcification occurs in about one third of all coronary artery lesions in patients with coronary artery diseases and is a problem in interventional cardiology due to technical difficulties. Percutaneous coronary intervention for coronary artery calcification is associated with a high risk of perioperative complications, adverse cardiovascular events in early and long-term follow-up compared with the results of treatment of patients without arterial calcification. One of the most important predictors of a favorable outcome after implantation of a drug-eluting stent is the optimal cross-sectional area of coronary stent. Intravascular imaging plays an important role in lesion assessment, selection of instruments and optimization of stent implantation, contemporary technologies modification of severe coronary artery calcification, as well as their combination, will probably lead to better procedural success and long-term results.
Event-based Boundary Control of the Stefan Problem: A Dynamic Triggering Approach

Field: Engineering (Physical Sciences)

The Stefan problem models a liquid-solid phase change phenomena as time evolution of a temperature profile in a liquid-solid material and its moving interface. This paper develops an event-triggered boundary control strategy for the one-phase Stefan problem. The proposed method consists of a full-state feedback backstepping boundary control law developed to drive the liquid-solid interface position to a desired setpoint and a dynamic event triggering mechanism which determines the time instants at which the control input requires to be updated. The existence of a minimal-dwell time between two consecutive events is proved, which eliminates the occurrence of the socalled Zeno phenomenon in the closed-loop system. The control input is updated at event times and applied in a Zero-OrderHold (ZOH) fashion. The well-posedness of the closed-loop system along with certain model validity conditions is proved. Furthermore, using the Lyapunov approach, it is shown that the proposed control approach globally exponentially converges the temperature profile to the melting temperature of the material in L 2 -norm and the moving interface to the desired setpoint. Finally, a simulation example is provided to validate the theoretical developments.
Annotated images from yeast cell lifespans - Trainingset - DetecDiv (id01)

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

This dataset has been generated by manual annotation from timelapse images of yeast cells dividing using the DetecDiv software (see below). It contains ~200 000 images from 200 cell lifespans (each lifespan is made of between 700 and 1000 images). Each image is classified between 6 classes: "1. unbudded", "2. small", "3. large", "4. dead", "5. empty", "6. clog", according to the subfolder of the image. Besides, this folder also contains a .mat file containing 200 timeseries of classes corresponding to the lifespan of the 200 cells. It has been used to train the network doi.org/10.5281/zenodo.5553862 from the software DetecDiv: github.com/gcharvin/DetecDiv biorxiv.org/content/10.1101/2021.10.05.463175v1 Data type: 3D microscopy images (3 stacks brightfield) (.tif) + annotation (.mat) Microscopy data type: Brightfield images with 3 stacks Imaging: 20x 0.45 NA brightfield, 6.5µm*6.5µm sCMOS Cell type: Budding yeast wild type cell (BY4742) File format: .tif (16-bit RGB, 1 color per z-stack) + .mat Image size: 60x60x1 (Pixel size: x,y: 325 nm, 3*z: 3*1325 nm) Author(s): Théo, ASPERT Contact email: theo.aspert@gmail.com Affiliation: IGBMC, Université de Strasbourg Funding bodies: This work was supported by the Agence Nationale pour la Recherche, the grant ANR-10-LABX-0030-INRT, a French State fund managed by the Agence Nationale de la Recherche under the frame program Investissements d'Avenir ANR-10-IDEX-0002-02.
THE EFFECT OF DEHYDRATION ON MUSCULAR ENDURANCE, ELECTROMYOGRAPHY, AND MECHANOMYOGRAPHY DURING ISOKINETIC MUSCLE ACTIONS OF THE BICEPS BRACHII

Field: Medicine (Health Sciences)

The purpose of the present investigation was to determine the effect of dehydration on the electromyographic (EMG) and mechanomyographic (MMG) responses during fatiguing isokinetic muscle actions of the biceps brachii. Nine college-aged (22 ± 1yrs, 77 ± 8kg), volunteers performed 25 maximal isokinetic (90°s−1) muscle actions of the biceps brachii in a euhydrated and dehydrated state as determined by changes in body weight and urine specific gravity. Subjects were tested on four separate occasions separated by at least 48 hours for the control (no fluid restrictions between testing sessions; c1 and c2) and dehydration (fluid restriction of 500 mL·day−1; d1 and d2) protocols. EMG and MMG were detected midway over the biceps brachii muscle during all testing. The average torque and amplitude (EMG and MMG) values for repetitions 1 thru 5, 11 thru 15, and 21 thru 25 were calculated and then analyzed using separate four (c1, c2, d1, d2) by three (repetitions) repeated measures ANOVAs. The analyses revealed no significant two-way interactions, which indicated that the subjects responded similarly in a eubydrated and dehydrated state for torque, EMG, and MMG. The results of the present investigation indicated that mild dehydration (2.9% decrease in BW) due to insufficient fluid intake does not affect the torque producing capabilities of a muscle, EMG amplitude, or MMG amplitude.Table: No Caption Available
Od trydenckiego do misjonarskiego modelu seminarium duchownego w siedemnastowiecznej Francji

Field: Arts and Humanities (Social Sciences)

This chapter examines the evolution of the seminary formation model, transitioning from the seminaries mandated by the Council of Trent to the first formation centers established by St. Vincent de Paul in 17th-century France. The deplorable state of some clergy and the unsuccessful attempts to implement Tridentine seminaries highlighted the necessity for reforms in the formation model. Significant changes were required not only in implementation but also in the concept itself, particularly regarding the low admission age of candidates. A pivotal development was the gradual introduction of pre-ordination retreats, which served as the foundation for further refinements. Before the seminary model familiar today fully emerged, early seminaries adhered to a fundamental formula developed in the mid-17th century. Among the most influential was the Vincentian model, established by the Congregation of the Mission. This model emphasized both the spiritual life of candidates and a pastoral approach, which was more practical than intellectual, equipping them to minister effectively, particularly in areas with a shortage of priests.
Nutritional Improvement and Rheological Characteristics of Tere (Rokak) Bread Supplemented with Inulin or Wheat Bran

Field: Agricultural and Biological Sciences (Life Sciences)

Nutritional, rheological, and sensory evaluation for Tere (Rokak) bread supplemented with 0, 2.5, 5, 7.5, and 10% of inulin or wheat bran were studied. The chemical composition of bread was slightly affected by these treatments, while energy values were reduced from 354.24 to 315.76 calories/100g. The results showed that Farinograph water absorption decreased from 70.2 to 50.3% and Mixing Tolerance Index from 34 to 0.00 BU with an increase in development time from 9.3 to 20 min, stability time from11-14.9 min, and quality number from 138-200 by increasing of inulin addition. The most pronounced effect of bran addition was on Farinograph stability and quality number which decreased from 9.3min and138 to 6.9min and 117 respectively. On the other hand, inulin decreased the Amylograph viscosity peak at heating from 840 t0 610 BU and the final viscosity at cooling from 1250 to 990 BU. Inulin addition significantly reduced the amount of required water to make Tere bread from 66% to 54% compared to control and bran. Inulin reduced about 3cm of bread diameter, while 7.5% of bran addition increased 3cm of Tere diameter. Also, the sensory evaluation showed that inulin and bran addition up to 10% had a slight effect on Tere bread compared to control , and their total acceptability was 70%-80%. No mold growth was observed on stored bread for three months which emphasized their resistance to any visible growth.
The Physiological Responses of Wild Tomatoes to Flooding during the Hot Season

Field: Agricultural and Biological Sciences (Life Sciences)

Heat and flooding are environmental stresses that inhibit tomato growth and productivity during the hot season in Taiwan. Selecting plant lines tolerant to flooding and heat would increase the productivity of tomato during the hot season. Two-month-old plants from the tomato lines Solanum pimpinellifolium L4422, S. habrochaites L3683, S. peruvianum L1947, and the tomato (S. lycopersicum L.) 'ASVEG #6' were flooded for 5 d during the hot season in Taipei. The relative water content, stomatal conductance, and chlorophyll fluorescence in the leaves, and the antioxidant contents, and activity of antioxidative and fermentative enzymes in the roots were measured. At 12 h after flooding, L1947 revealed a rapid decrease in stomatal conductance and Fm value, higher α-tocopherol content and Fv/Fm value than L4422, and higher alcohol dehydrogenase activity than that in the other three Solanum plants. The Fm values for L1947 and L3683 decreased earlier (at 12 h) than 'ASVEG #6' and L4422 (at 24 h) after flooding. The ascorbate peroxidase activity and fresh weight in L1947 root were increased at 48 h after flooding. Thus, among the four Solanum plants studied, L1947 is more tolerant to flooding during the hot season in Taipei.
Evaluation of the Use of Thonningia sanguinea (THOS) Meal in Different Rations on the Morphological Parameters of Local Breed Chicken Farmed in Côte d'ivoire

Field: Agricultural and Biological Sciences (Life Sciences)

Background and Objective: The use of Thonningia sanguinea (THOS) in domestic animal feed not only enhances the available natural resources and contributes to food self-satisfaction, but also makes local poultry farming profitable.Thus dietary supplementation of extract of Thonningia sanguinea on the morphometric parameters of local chicken Gallus gallus domesticus raised in confinement was the subject of this study.Materials and Methods: Four batches of local breed chickens (60 per batch) and four feeds were set up, in particular a control feed (THOS 0%) and three supplemented feeds (THOS 5%, THOS 10% and THOS 15%).The data on the measurement of the subjects was collected from week 12, then weeks 16, 20, 24 and 30.Results: The measurements of the legs show that the chickens fed with THOS 5% and those fed with THOS 10% had skeletal and muscle development faster than chickens fed the control diet and those on THOS 15% between 12 and 16 weeks of age.Beyond 20 weeks of age, chickens fed THOS 5% show skeletal development and muscles greater than chickens fed the other supplemented feeds.Conclusion: This study showed that supplementation with Thonningia sanguinea powder at 5% in the feed allows local chicken growth, both muscular and skeletal and can be recommended in poultry farming.
Predictors of oral mucosal lesions among removable prosthesis wearers

Field: Dentistry (Health Sciences)

Background and purpose: The purposes of this study were to analyse the prevalence of oral mucosal lesions with an emphasis on oral regions and possible predictors for their occurrence among removable prosthesis wearers.Materials and methods: The study included 125 removable prosthesis wearers (96 women and 29 men) who were divided into two groups: complete (n=86) and partial (n=39) denture prosthesis wearers. Predictors and oral mucosal lesions were assessed using a questionnaire and clinical oral examination. Multiple logistic regression was used to assess the association of oral lesions with predictors.Results: Oral mucosal lesions presented in 74.40% of examinees and their occurrence was linked to the male gender (p=0.045, OR 3.72; 95% CI:1.03-13.39) and xerostomia (p=0.005, OR 4.472; 95% CI:1.56-12.79). The majority of the lesions were present on the tongue (50.40%) and palate (43.20%), with the least occurring on the oral cavity floor (2.40%). The occurrence of palatal lesions was linked to age (p=0.008, OR 1.097; 95% CI:1.03-1.18), prosthesis age (p=0.002, OR 1.817; 95% CI:1.72-1.93), prosthesis wearing at night (p<0.001, OR 13.01; 95% CI:1.82-18.98), smoking (p=0.033, OR 4.532; 95% CI:1.13-18.11) and xerostomia (p=0.003, OR 5.874; 95% CI:1.81-18.98). The occurrence of tongue lesions was linked to age (p=0.042, OR 1.135; 95% CI:1.02-1.25).Conclusions: Increased care and frequent follow-ups need to be implemented among denture prosthesis wearers that are male, elderly, smokers, who wear prosthesis at night and patients with older prosthesis in order to diagnose and cure oral mucosal lesions in time.
Clinical utility of secukinumab in moderate-to-severe scalp psoriasis: evidence to date

Field: Medicine (Health Sciences)

Dario Kivelevitch,1 Sima Amin,2 Alan Menter11Baylor University Medical Center, Dallas, TX, USA; 2Texas A&M College of Medicine, Bryan, TX, USAAbstract: Psoriasis is an immune-mediated inflammatory dermatosis commonly affecting the scalp and fringes of the face, neck and ears. It may be difficult to treat and the presence of extensive and highly visible lesions may significantly influence psychosocial well-being. Secukinumab, a monoclonal antibody that selectively targets interleukin-17A and has been shown to provide robust and sustained efficacy for whole body psoriasis. In this review, we evaluate the evidence to date of secukinumab in patients with moderate-to-severe scalp psoriasis. A comprehensive Cochrane database and PubMed searches of all available literature in English through September 2018 was performed using the search terms: “psoriasis”, “scalp” and “secukinumab”. Based on current evidence, we conclude that secukinumab is efficacious and well-tolerated treatment for patients with moderate-to-severe scalp psoriasis. Further studies are however warranted.Keywords: secukinumab, psoriasis, scalp, therapy
Does Winning a Pay‐for‐Performance Bonus Improve Subsequent Quality Performance? Evidence from the Hospital Quality Incentive Demonstration

Field: Social Sciences (Social Sciences)

Objective To test whether receiving a financial bonus for quality in the P remier H ospital Q uality I ncentive D emonstration ( HQID ) stimulated subsequent quality improvement. Data Hospital‐level data on process‐of‐care quality from H ospital C ompare for the treatment of acute myocardial infarction ( AMI ), heart failure, and pneumonia for 260 hospitals participating in the HQID from 2004 to 2006; receipt of quality bonuses in the first 3 years of HQID from the P remier I nc. website; and hospital characteristics from the 2005 A merican H ospital A ssociation A nnual S urvey. Study Design Under the HQID , hospitals received a 1 percent bonus on M edicare payments for scoring between the 80th and 90th percentiles on a composite quality measure, and a 2 percent bonus for scoring at the 90th percentile or above. We used a regression discontinuity design to evaluate whether hospitals with quality scores just above these payment thresholds improved more in the subsequent year than hospitals with quality scores just below the thresholds. In alternative specifications, we examined samples of hospitals scoring within 3, 5, and 10 percentage point “bandwidths” of the thresholds. We used a G eneralized L inear M odel to estimate whether the relationship between quality and lagged quality was discontinuous at the lagged thresholds required for quality bonuses. Principal Findings There were no statistically significant associations between receipt of a bonus and subsequent quality performance, with the exception of the 2 percent bonus for AMI in 2006 using the 5 percentage point bandwidth (0.8 percentage point increase, p < .01), and the 1 percent bonus for pneumonia in 2005 using all bandwidths (3.7 percentage point increase using the 3 percentage point bandwidth, p < .05). Conclusions We found little evidence that hospitals' receipt of quality bonuses was associated with subsequent improvement in performance. This raises questions about whether winning in pay‐for‐performance programs, such as H ospital V alue‐Based P urchasing, will lead to subsequent quality improvement.
ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

Field: Medicine (Health Sciences)

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.
Reducing The Number of Intermediate Stock by Implementing Just-In-Time & Pulling System

Field: Decision Sciences (Social Sciences)

In tire manufacturing process in PT. XYZ, there is an area called the Intermediate Area in the Building - Curing area where WIP materials are temporarily stored before proceeding to the Curing process. The capacity of Intermediate Area is 15000 pcs, and the daily production volume approximately 20000 pcs. As a result, more space in the Intermediate Area is required to accommodate the increasing tire production planning. In this study, JIT & Pull system improvement process is carried out by following the PDCA cycle methodology. The implementation of the JIT done by determining standard for the number of intermediate stocks, whereas the Pull system implementation done by setting the standard material handling cycle time standard for one cycle. To keep the improvement runs according to the plan, the guidance sheet is made as the reference of the process. These improvements done to achieve the objective which is to reduce the number of stocks in the Intermediate Area by up to 834 pcs per day and reduce the total cycle time from 110 minutes to 90 minutes. Therefore, the main contribution of this research is to reduce the number of WIP materials in intermediate area and reduce the excessive transportation in the material handling process.