jimnoneill/paper-to-field-training huggingface dataset:
CircRNA_0005075 suppresses carcinogenesis via regulating miR‐431/p53/epithelial‐mesenchymal transition axis in gastric cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

This study was aimed to explore the expression and biological function of circRNA_0005075 in gastric cancer (GC) progression and its underlying mechanism. First, the expression level of circRNA_0005075 and microRNA‐431 (miR‐431) in GC tissues were detected with the quantitative real‐time polymerase chain reaction. In addition, after down‐regulated the circRNA_0005075 expression by plasmid transfection in GC cells, the Cell Counting Kit‐8 (CCK‐8), EDU, transwell assay were conducted to evaluate the function of circRNA_0005075 or miR‐431 on cell proliferation, metastasis in vitro. Moreover, p53 and Epithelial‐mesenchymal transition (EMT) pathway related proteins were also measured with western blotting. Then, our data revealed that CircRNA_0005075 was found to be significantly up‐regulated in GC tissues as well as GC cell lines, and the GC patients with higher CircRNA_0005075 expression were more likely to have poor outcomes. Down‐regulation of CircRNA_0005075 could significantly suppress the GC cell proliferation and cell metastasis ability, while the addition of miR‐431 inhibitors could counteract this effect. Importantly, we discovered that the silencing of circRNA_0005075 could weaken the micro‐RNA sponge function for miR‐431, and then upregulate the expression of p53 and forbid the EMT signalling pathway, and finally suppress the tumourigenesis of GC. To sum up, CircRNA_0005075 could inhibit cell growth and metastasis of GC through regulating the miR‐431/p53/EMT axis. Significance of the study The research clearly elucidated the potential role and relative regulatory mechanism of circRNA_0005075 in gastric cancer (GC) progression. Briefly, circRNA_0005075 could directly inhibit the expression level of miR‐431, then regulate the p53/Epithelial‐mesenchymal transition axis, and finally inhibit cell growth and metastasis in GC. Consequently, circRNA_0005075 might act as an oncogene in the GC procession, which provides a promising way for the treatment of GC.
E-Government, Service Transformation, and Procurement Reform in Canada

Field: Social Sciences (Social Sciences)

New organizational arrangements are required to underpin emerging public sector service transformation initiatives with a substantial electronic government (e-government) dimension. These arrangements are both internal to government, involving new collaborative relationships among service delivery agencies and reform of procurement processes, and external, involving the formation and management of strategic relationships between private sector information technology (IT) vendors and public service providers. This article explores the relational context of service transformation by first examining some current initiatives in Canada—at both provincial and federal levels. These case studies reveal the nexus between digital technologies, internal organizational change, and public–private sector interactions. They also reveal the emergence of new collaborative mechanisms between both sectors, especially in the initial phase of relationships where the IT-enabled service transformation is being mutually defined. This heightened level of collaboration also represents a significant departure from traditional government procurement models—where inputs are defined by public authorities and then secured in the marketplace from qualified vendors. E-government—and service transformation initiatives in particular—are consequently driving a rethinking of the role and purpose of procurement mechanisms in an increasingly digital and interdependent environment. Many political and administrative quandaries remain, however, as governments struggle to achieve a balance between traditional public interest principles such as probity, transparency, and accountability, and the rising importance of strategic collaboration. Building on the case studies and a review of current efforts at procurement reform, this article offers and assessment of how this interrelationship between service transformation and public–private collaboration is likely to shape future e-government-based service transformation efforts in Canada.
Supplementary Table S1 from Epigenetic Regulation of the Homeobox Gene <i>MSX1</i> Associates with Platinum-Resistant Disease in High-Grade Serous Epithelial Ovarian Cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>Clinical characteristics for Hammersmith Hospital (HH) and The Cancer Genome Atlas (TCGA) datasets.</p>
Humoral and Cellular Vaccination Responses against SARS-CoV-2 in Hematopoietic Stem Cell Transplant Recipients

Field: Medicine (Health Sciences)

The cellular response to SARS-CoV-2 vaccination and infection in allogeneic hematopoietic stem cell transplant (HSCT) recipients is not yet clear. In the current study, HSCT recipients prior to and post vaccination were tested for SARS-CoV-2-specific humoral and cellular immunity. Antibodies against spike (S) 1 were assessed by Anti-SARS-CoV-2 IgG ELISA (Euroimmun). Cellular immunity was analyzed by an in house interferon-gamma ELISpot and T-SPOT.COVID (Oxford Immunotec), using altogether seven SARS-CoV-2-specific antigens. In 117 HSCT patients vaccinated twice, SARS-CoV-2 IgG antibodies were significantly higher than in HSCT controls pre vaccination (p < 0.0001). After the second vaccination, we observed a median antibody ratio of 4.7 and 68% positive results, whereas 35 healthy controls reached a median ratio of 9.0 and 100% positivity. ELISpot responses in patients were significantly (p < 0.001) reduced to ≤33% of the controls. After the second vaccination, female HSCT patients and female healthy controls showed significantly higher antibody responses than males (6.0 vs. 2.1 and 9.2 vs. 8.2, respectively; p < 0.05). Cellular immunity was diminished in patients irrespective of sex. In conclusion, especially male HSCT recipients showed impaired antibody responses after SARS-CoV-2 vaccination. Changing the vaccine schedule or composition could help increase vaccine responses.
US‐Japan distribution channel cost structures: is there a significant difference?

Field: Business, Management and Accounting (Social Sciences)

The Japanese distribution system is often accused of being inefficient and responsible for high consumer prices. Discusses some critical dimensions that make distribution appear to be less efficient in Japan than the US. An empirical study compares distribution costs at all levels of the channel in the two countries, including the costs of distributing industrial products, which are ultimately borne by the consumer. Provides evidence that cost structures are similar for the two countries. Discusses implications for distribution planners.
A transient detection and monitoring pipeline for LOFAR

Field: Physics and Astronomy (Physical Sciences)

When LOFAR, the LOw Frequency ARray, comes online over the next few years, it will provide an unprecedented sensitivity and field of view in the low-frequency radio regime.The Transients Key Project aims to exploit these capabilities by constructing an automatic system for monitoring the sky for transient sources with LOFAR.Such a project requires automatic processing and archiving of a huge volume of data, presenting a software design and engineering challenge.Here, we present an overview of some of the technical issues faced, as well as outlining the approaches adopted to address them.
Brushing up on Your Maintenance Practices

Field: Engineering (Physical Sciences)

The successful long-term operation of DC motors and generators, like the operation of any piece of industrial equipment, requires maintenance. Scheduled, periodic, visual inspections and the recording of this data are valuable information when reviewing that machines' performance. These written inspection reports serve much better than the memory of the maintenance technician or supervisor when questioning the performance history of a certain piece of equipment. A generic inspection record format is included, along with guidelines to help make decisions on the health status of these motors. This article expands on ten major items of concern for the successful long-term operation of DC machines.
Allelopathic Effect of Zanthoxylum bungeanum Extracts on Seed "Germination and Seedling Groeth of Soybean

Field: Agricultural and Biological Sciences (Life Sciences)

The allelopathic effects of different concentrations of aqueous extract of Zanthoxylum bungeanum leaves on seed germination and early seedling growth of three soybean varieties were investigated.The results showed that the inhibition of plant growth enhanced as the extract concentration increased.Both the data of morphological and biochemical parameters suggested that the extract at concentration ≥40 g L-1 strongly inhibited seed germination and seedling growth of soybean.However,the extract at concentration ≤20 g L-1 promoted the germination rate of seed with lower vigor,whereas the seed germination index decreased and seed germination time was prolonged.Different change patterns of seed germination were observed among the three varieties,indicating that allelopathic action was affected by either seed vigor or genotype.With the concentration of aqueous extract increasing,the MAD content increased constantly,while SOD activity was significantly inhibited.The sensitivity of seedling to the allelopathic effects of Z.bungeanum was in the order of underground biomass aboveground biomass plant height root length.Fig 2,Tab 3,Ref 12
An IoT-Enabled Machine Learning Framework for Automated Teacher Performance Feedback to Enhance Teaching Quality

Field: Computer Science (Physical Sciences)

Given the crucial role of teachers in the education system, robust mechanisms are necessary to enhance their teaching effectiveness. Through leveraging advanced technological methods, both teacher and student evaluation processes can be conducted with high accuracy. This study proposes an IoT-based automated teacher performance evaluation system that utilizes machine learning algorithms and computer vision techniques to provide immediate feedback on teaching performance to supervisors. The system analyzes key elements such as hand movements and the teacher's position in the classroom. By enhancing teaching performance, the model aims to improve student learning outcomes. In addition, to develop and test the system, a hypothetical dataset - called the teacher dataset - was created for this proposed model by collecting 35 publicly available videos from YouTube. This approach employs a ResNet50 pre-trained neural network for transfer learning and feature extraction to classify teacher behavior into 8 classes. Fuzzy logic converts the predictions into three teaching quality ratings (poor/medium/good). Using this custom dataset, the model achieved an accuracy of 84.8%, indicating strong performance. This approach enables automated feedback on teaching style, reducing the need for in-person evaluations by educational supervisors. The proposed system has the potential to significantly enhance the overall quality of teaching and learning.
Electric dipole moments from spontaneous CP violation in SU(3)-flavoured SUSY

Field: Physics and Astronomy (Physical Sciences)

The SUSY flavour problem is deeply related to the origin of flavour and hence to the origin of the SM Yukawa couplings themselves. Since all CP-violation in the SM is restricted to the flavour sector, it is possible that the SUSY CP problem is related to the origin of flavour as well. In this work, we present three variations of an SU(3) flavour model with spontaneous CP violation. Such models explain the hierarchy in the fermion masses and mixings, and predict the structure of the flavoured soft SUSY breaking terms. In such a situation, both SUSY flavour and CP problems do not exist. We use electric dipole moments and lepton flavour violation processes to distinguish between these models, and place constraints on the SUSY parameter space.
Relationship and Process in Sandplay: A Self-Psychology Perspective

Field: Psychology (Social Sciences)

This author relates the similarities between Sandplay Therapy and Self Psychology, by comparing the work of Heinz Kohut, the father of Self Psychology and Dora Kalff, the mother of Sandplay Therapy. Both approaches speak to the importance of the therapist, client relationship, with empathy and mirroring. The relationship of the self-object is described in both therapies. A partial sandplay process is described from the two perspectives.
Some Intercultural Roots of Purāṇic Mythological Cycle around Nārāyaṇa

Field: Arts and Humanities (Social Sciences)

ABSTRACTIn this paper, I use the structural analysis of myth proposed by C. Lévi-Strauss to show that there is a structural similarity between two mythological cycles of dying(sleeping)-and-rising god: around Ba’al and around Nārāyaṇa. On the one hand, the West Semitic myth of Ba’al and the Purāṇic myth of Nārāyaṇa have different descriptions and assume different cults. On the other hand, we can detect a homotopy equivalence among mythemes of both cycles – i.e., a functional similarity in their characters and subordinations. As we know, the earliest Purāṇic texts are dated from the second century AD. The myth about Ba’al appeared not later than the fifteenth century among West Semitic peoples and was popular among the Hittites, too. From the structural similarity between Ba’al and Nārāyaṇa myths it follows that the Purāṇic myth of Nārāyaṇa is much older than it is dated now.
Identification of Mitogen-Responsive Ribosomal Protein S6 Kinase pp90rsk, a Homolog of Xenopus S6 Kinase II, in Chicken Embryo Fibroblasts

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Antiserum raised against recombinant Xenopus ribosomal protein S6 kinase (rsk) was used to identify a 90,000-Mr ribosomal S6 kinase, pp90rsk, in chicken embryo fibroblasts. Adding serum to cells stimulated the phosphorylation of pp90rsk on serine and threonine residues and increased the activity of S6 kinase measured in immune complex assays. Xenopus S6 kinase II and chicken embryo fibroblast pp90rsk had nearly identical phosphopeptide maps.
Optimization and evaluation of a two-stage chromogenic tenase assay for measurement of emicizumab plasma levels

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

A two-stage chromogenic tenase assay allows specific measurement of emicizumab plasma levels over a broad concentration range (10 µg/ml to 100 µg/ml). The assay showed a reasonable agreement with one-stage clotting assy used for emicizumab quantificaition and can be applied on an automated coagulation analyzer, demonstrating its applicability within a routine laboratory setting.
Glutamine synthetase and hepatocarcinogenesis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Glutamine synthetase and hepatocarcinogenesis Gebhardt Rolf, Gebhardt Rolf 2 2To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Gary M. Williams Gary M. Williams 1American Health Foundation1 Dana Road, Valhalla, NY 10595, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Carcinogenesis, Volume 16, Issue 8, August 1995, Pages 1673–1681, https://doi.org/10.1093/carcin/16.8.1673 Published: 01 August 1995 Article history Received: 28 October 1994 Revision received: 03 April 1995 Accepted: 14 April 1995 Published: 01 August 1995
Thermal Analysis of High Level Waste Geological Disposal Module With the Thermal Code SYRTHES

Field: Engineering (Physical Sciences)

Within the framework of the 2006 French law on sustainable management of radioactive materials and waste, an evaluation of the industrial perspectives of GENERATION IV Fast Reactors deployment is requested for 2012. In this context, questions about waste storage capacities are of interest for EDF (Electricite de France). The storage area is driven by thermal requirements on the argilite formation surrounding the canisters. The size of the final radioactive waste geological repository is one indicator of interest in these studies. The repository considered has been proposed by ANDRA, the French national agency in charge of the radioactive waste management. Optimisation studies on the number of canisters per cell or the distance between two cells using the open source thermal code SYRTHES and SALOME have been presented in previous conferences. However, due to the very large number of calculations induced they are performed on a limited domain. To evaluate the thermal conservatism of a reduced domain, three levels of modeling have been used: a domain limited to half a cell, a slice of half a module (ie three half cells), and a complete half module leading to a very large finite element model (more than 82 million cells), in which all the disposal cells (around 150 of them containing 6 waste packages each) are represented. Two theoretical heat deposit functions have been used representative of waste leading to early and late temperature peaks. This paper presents the thermal code SYRTHES used to simulate large model for transient lasting up to 4000 years. Results show that clay temperature surrounding cells located on the periphery are cooler than those located near the center of the module. For early peaks a reduced domain is well adapted for optimization studies, while for late peak wastes, taking into account an extended domain seems interesting since the large case underlines that optimizing on a reduced domain is clearly conservative.Copyright © 2012 by ASME
Lewis Number Effects on Turbulent Premixed Flame Structure

Field: Physics and Astronomy (Physical Sciences)

ABSTRACT The influence of the Lewis number on turbulent flame front geometry is investigated in a premixed turbulent stagnation point flame. A laser tomography technique is used to obtain the flame shape, a fractal analysis of the multiscale flame edges is performed and the distribution of local flame front curvature is determined. Lean H2/Air and C3H8/Air mixtures with similar laminar burning rates were investigated with Lewis numbers of 0·33 and 1·85 respectively. At the conditions studied the laminar H2/Air mixture is unstable and a cellular structure is observed. Turbulence in the reactant stream is generated by a perforated plate and the turbulent length scale (3 mm) and intensity (7%) at the nozzle exit are fixed. The equivalence ratio is set so that the laminar burning velocity is the same for all the cases. The results show clearly that the turbulent flame surface area is dependent on the Lewis number. For a Lewis number less than unity surface area production is observed. The shape of the flame front curvature distribution is not found to be very sensitive to the Lewis number. For the H2/Air mixture the distribution is skewed toward the positive values indicating the presence of cusps while for the C3H8/Air mixture the distribution is more symmetrical. In both cases the average curvature is found to be zero, and if the local burning speed varies linearly with curvature, the local positive and negative burning velocity variations due to curvature will balance.
721-P: Efficacy and Safety of Basal-First Titration Order in Patients with Type 2 Diabetes (T2D) Receiving Short-Term Intensive Insulin Therapy (SIT)

Field: Medicine (Health Sciences)

To titrate basal and bolus insulin sequentially or simultaneously during SIT remains controversial. Here we report an easy titration order verified in a 7-10 day SIT period. Insulin naïve Chinese T2D adults receiving stable doses of metformin and 1-2 oral antihyperglycemic drugs with HbA1c 7.5%-11.0% were treated with once-daily insulin glargine 100 U/mL (Gla-100) and thrice-daily insulin glulisine (Glu) for 7-10 days titrated to achieve a fasting blood glucose (FBG) <7 mmol/L and 2-hour postprandial glucose (2hPG) <10 mmol/L. Gla-100 was titrated first until FBG achieved 4.4-6.1 mmol/L, then Glu was titrated to achieve pre-meal blood glucose 4.4-6.1 mmol/L. Of 466 patients screened, 397 entered the SIT period; 391 (98.5%) completed. Baseline mean (SD) age was 54.2 (8.8) years, duration of disease was 6.8 (3.0) years, BMI was 26.0 (3.2) kg/m2, HbA1c was 9.1% (1.1), and FBG was 10.7 (2.5) mmol/L; 59.2% were male. Overall, 94.4% of patients achieved the predefined target at the end of the SIT period (Table). The mean time to first achieving 2hPG target was less than the time to first achieving FBG target, implying that titrating basal insulin first could minimize Glu dose increases and potential hypoglycemia risk.In conclusion, when starting basal-bolus regimen in SIT, basal-first titration order was effective, fast to target and well tolerated in Chinese T2D patients.View largeDownload slideView largeDownload slide DisclosureL. Guo: Consultant; Self; AstraZeneca, Bayer Healthcare Pharmaceuticals Inc., BD, Eli Lilly and Company, Merck & Co., Inc., Merck Sharp & Dohme Corp., Novartis AG, Novo Nordisk, Sanofi China. J. Liu: Employee; Self; Sanofi China. X. Zhang: None. N. Cui: Employee; Self; Sanofi China. H. Yin: None. Y. Mu: Speaker’s Bureau; Self; Abbott, Boehringer Ingelheim Pharmaceuticals, Inc., Lilly Diabetes, Novo Nordisk Inc., Sanofi-Aventis. H. Wan: None. J. Wang: None. B. Xu: None. G. Wang: None. C. Jiang: None. L. Liang: None. W. Feng: Employee; Self; Sanofi China.FundingSanofi China (NCT03359837)
Grenselandet mellom yrkesetikk og god klinisk praksis – en kasuistikk

Field: Dentistry (Health Sciences)

English summary The boundary between professional ethics and good practice Nor Tannlegeforen Tid. 2025; 135: 360-5. The authors describe a case in which a patient sought dental treatment for aesthetic correction of an asymmetric midline, proximal discoloration (11. 21), and tooth shape issues in the anterior maxilla. This case is presented from four perspectives: the patient’s perception of the treatment situation, the specialist clinic at the Department of Clinical Dentistry at the University of Bergen that reviewed the treatment, the expert assessment from the Norwegian National Patient Complaint Board (NPE), and the decision made by the Vestland County Governor, who oversees patient complaints. The dentist provided extensive irreversible treatment, preparing and cementing full crowns on eight teeth (14–24). No X-rays were taken before or after the treatment. The outcome failed to meet the patient's aesthetic or functional needs. This case study illustrates how a lack of professional ethics and adherence to sound clinical practice can adversely affect a patient’s health, well-being, and financial stability.
Modelling of the Gettering by Mechanical Damage of the Metallic Impurities in Silicon

Field: Materials Science (Physical Sciences)

减少在场的金属性的杂质的集中基于 insilicon 的电子部件戏在制造的一个重要角色。由导致的机械损坏的用吸气剂吸气是在抵销这些杂质使用的方法之一。模仿这类用吸气剂吸气，我们明确地由于机械损坏包括陷井的角色，基于撵走的机制。在我们的模型，我们包括杂质的集中选择必要参数，厚度，温度，时间，等等。从文学估计的硅 interstitials 的散开系数和平衡集中被适应了在对试验性的数据的好同意。