jimnoneill/paper-to-field-training huggingface dataset:
STEAP2 is differentially expressed in lymph node metastasis in human breast cancer.

Field: Medicine (Health Sciences)

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that STEAP2 metalloreductase, STEAP2, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Analysis of a separate microarray dataset revealed that STEAP2 was also differentially expressed in brain metastatic tissues. STEAP2 mRNA was present at decreased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of STEAP2 in primary tumors of the breast was correlated with patient post-progression survival, in lymph node positive patients but not in lymph node negative patients. Modulation of STEAP2 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer.
Major and chronic diseases, report 2007.

Field: Health Professions (Health Sciences)

Blind spots in European health information\nOn June 6th 2008 the European Commission has published the Major and Chronic Diseases Report 2007. This report describes the state of the art of health information in Europe on 13 prevalent chronic conditions. Large differences between the Member States of the European Union became apparent. \n\nFor example, as compared to the old Member States, in the new Member States there is considerable premature death of Cardiovascular causes, which to a large extent is preventable. And Diabetes care for elderly patients seems to be inadequate in several Member States. Besides these topics, the report gives an overview of available health information for Autistic Spectrum Disorders, Cancer in general and more specifically Haematological Malignancies, Dementia, Depression, Maternal and Child Health, Multiple Sclerosis, Musculoskeletal Conditions, Oral Health, Sexual and Reproductive Health, and Life Expectancy with Chronic Morbidity. \n\nBesides giving an overview of available data, the report aims to identify urgent gaps in information. This makes the report an important tool for both national and supranational policy makers. Next to that, the report will be a comprehensive guide for public health experts and researchers, showing them the availability, quality and comparability of data on major and chronic diseases in Europe.\n\nThe report was written by public health experts of the Task Force on Major and Chronic Diseases of the Health Information Strand of the Programme for Community Action in the field of Public Health 2003-2008. NIVEL has, through the DG SANCO funded Scientific Assistance Office (SAO) project, coordinated and supported the writing of the Major and Chronic Diseases Report 2007, and has contributed to the contents of the report.
Overexpression of SRG3/SWI3 protein disrupts the cell cycle progression in mature t cells and yeast

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Mouse T cells overexpressing the SRG3 protein displayed morphological changes; the cells were enlarged and their shapes were irregular compared to the normal parental cells. In addition, growth rate of the cells was dramatically reduced and their DNA contents were increased. The increased DNA contents were due to an increase in number of chromosomes in these cells. We have observed similar results in S. cerevisiae cells overexpressing the yeast SWC protein. Yeast cells overexpressing SWC protein displayed the phenotypes of highly elongated buds and 2C DNA content. These results suggest that the SRG3/SWC protein plays an important role in cell growth and cell cycle progression.
The Economic Cost of Methamphetamine Use in the United States, 2005

Field: Economics, Econometrics and Finance (Social Sciences)

This first national estimate of the economic cost of methamphetamine (meth) use in the United States suggests that costs reached $23.4 billion in 2005. The analysis, with a lower-bound estimate of $16.2 billion and an upper-bound estimate of $48.3 billion, considers the burden of addiction, premature death, drug treatment, lost productivity, crime and criminal justice, health care, production and environmental hazards, and child endangerment.
PIMT-Mediated Labeling of l-Isoaspartic Acid with Tris Facilitates Identification of Isomerization Sites in Long-Lived Proteins

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Isomerization of individual residues in long-lived proteins (LLPs) is a subject of growing interest in connection with many age-related human diseases. When isomerization occurs in LLPs, it can lead to deleterious changes in protein structure, function, and proteolytic degradation. Herein, we present a novel labeling technique for rapid identification of l-isoAsp using the enzyme protein l-isoaspartyl methyltransferase (PIMT) and Tris. The succinimide intermediate formed during reaction of l-isoAsp-containing peptides with PIMT and S-adenosyl methionine (SAM) is reactive with Tris base and results in a Tris-modified aspartic acid residue with a mass shift of +103 Da. Tris-modified aspartic acid exhibits prominent and repeated neutral loss of water when subjected to collisional activation. In addition, another dissociation pathway regenerates the original peptide following loss of a characteristic mass shift. Furthermore, it is demonstrated that Tris modification can be used to identify sites of isomerization in LLPs from biological samples such as the lens of the eye. This approach simplifies identification by labeling isomerization sites with a tag that causes a mass shift and provides characteristic loss during collisional activation.
Some Problems of Wartime Neurology

Field: Neuroscience (Life Sciences)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
China’s role in mitigating poverty and inequality in Africa: an empirical query

Field: Economics, Econometrics and Finance (Social Sciences)

Using data from 1995 to 2017, this article shows that China plays a positive role in mitigating poverty and inequality in Africa. Namely, imports from China, especially imports of machinery and equipment but not manufactured goods, alleviate substantially poverty in the region. In addition, China’s foreign direct investment (FDI) and China’s engagement in infrastructure projects in the continent help not only eradicate poverty, but also narrow income inequality. However, total exports or exports of raw materials and fuels to China are irrelevant to income distribution. We also compare these impacts with the impacts of economic links with the United States (US) and find insignificant effects of the US’s imports and FDI on income distribution but some positive effects of exports to the US on poverty in Africa. Our findings are robust when both the fractional nature of poverty and inequality indices and their correlation are taken into account.
Cytotoxic potential of different lymphoid cell populations against chromium-51 labelled tumour cells.

Field: Immunology and Microbiology (Life Sciences)

Release of chromium-51 (51Cr) from pre-labelled target cells was used as an assay of cytotoxicity. Different immune and non-immune lymphoid cell populations were tested for in vitro cytotoxicity against pre-labelled tissue culture target cells (Ha 3) which originated from a tumour induced by murine sarcoma virus (MSV) in a CBA mouse. Anti-Ha 3 peritoneal exudate and spleen cells showed significant specific cytotoxicity against these target cells. This was true for cells taken from animals immunized against either strong (H-2 plus non-H-2) or weak (non-H-2) antigenic determinants on the Ha 3 cells. Exogenous complement was not required for this cytotoxic activity. Tissue culture cells derived from a methylcholanthrene-induced tumour (MBE) of CBA origin were not damaged by peritoneal exudate cells from mice immunized against non-H-2 antigens on the Ha 3 cells. Anti-Ha 3 lymph node cells were relatively ineffective in these experiments although some cytotoxic activity was detected with lymph node cells sensitized against strong antigens. Direct morphological observation confirmed the cytotoxicity of anti-Ha 3 peritoneal exudate cells measured by 51Cr release.
Group sparse kernelized dictionary learning for the clustering of white matter fibers

Field: Computer Science (Physical Sciences)

This paper presents a novel method that combines kernelized dictionary learning and group sparsity to efficiently cluster white matter fiber tracts obtained from diffusion Magnetic Resonance Imaging (dMRI). Instead of having an explicit feature representation for the fibers, this method uses a non-linear kernel and specialized distance measures that can better learn complex bundles. Through the use of a global sparsity prior, the method also provides a soft assignment of fibers to bundles, making it more robust to overlapping fiber bundles and outliers. Furthermore, by using a group sparsity prior, it can automatically discard small and uninteresting bundles. We evaluate our method both qualitatively and quantitatively using expert labeled data, and compare it with state of the art approaches for this task.
Socioeconomic Determinants of Tree Planting on Farmers Landholding, in Womberma District, Northwestern Ethiopia

Field: Social Sciences (Social Sciences)

The study was conducted at Womberma district, northwestern Ethiopia with intended to identify the socioeconomic determinants of tree integration on farmer’s landholding. Farm visits and total enumeration of trees species on respondent’s landholding in different tree growing niches, household interview, and key informant interview were used for data collection. Data were analyzed with multiple linear regression model. The result shows that all the considered predictor variables jointly influenced the total number of tree integrated on their own lands with a coefficient of determination (R 2 , 0.719 and 0.600 in the two study sites). Among the household characteristics that were entered to the model, landholding size, farming experience and wealth status of the household have been significantly related to the number of trees maintained per household. The number of tree stems and tree species per household increase with increasing wealth statuses of households, farming experience, and landholding size. Keywords: Household, Tree species, Wealth status, Tree integration DOI: 10.7176/JESD/11-7-04 Publication date: April 30 th 2020
The Predicting Life of Automobile Gear by Dry Machining

Field: Engineering (Physical Sciences)

High speed dry cutting gear reliability life test in the presence of the test cost, sample need more, experiment analysis work tedious and complex and difficult to obtain data from all the problems, this article discusses the use of grey system theory based on GM (1, 1) model fitting of automobile gear reliability life test data method, grey models can be based on the experiment less data predict the life of automobile gear test follow-up data. Instance calculation shows. The precision of the model with residual test, after test and correlation test requirements, calculation value and actual measuring value degree of good, can be satisfy the test requirements.
Efficient All‐Perovskite Tandem Solar Cells with Low‐Optical‐Loss Carbazolyl Interconnecting Layers

Field: Materials Science (Physical Sciences)

Abstract Combining wide‐band gap (WBG) and narrow‐band gap (NBG) perovskites with interconnecting layers (ICLs) to construct monolithic all‐perovskite tandem solar cell is an effective way to achieve high power conversion efficiency (PCE). However, optical losses from ICLs need to be further reduced to leverage the full potential of all‐perovskite tandem solar cells. Here, metal oxide nanocrystal layers anchored with carbazolyl hole‐selective‐molecules (CHs), which exhibit much lower optical loss, is employed to replace poly(3,4‐ethylenedioxythiophene) polystyrenesulfonate (PEDOT : PSS) as the hole transporting layers (HTLs) in lead‐tin (Pb‐Sn) perovskite sub‐cells and ICLs in all‐perovskite tandem solar cells. Optically transparent indium tin oxide nanocrystals (ITO NCs) layers are employed to enhance anchoring of CHs, while a mixture of two CHs is adopted to tune the surface energy‐levels of ITO NCs. The optimized mixed Pb‐Sn NBG perovskite solar cells demonstrate a high PCE of 23.2 %, with a high short‐circuit current density ( J sc ) of 33.5 mA cm −2 . A high PCE of 28.1 % is further obtained in all‐perovskite tandem solar cells, with the highest J sc of 16.7 mA cm −2 to date. Encapsulated tandem solar cells maintain 90 % of their reference point after 500 h of operation at the maximum power point (MPP) under 1‐Sun illumination.
Sawflies (Hymenoptera: Argidae, Pergidae, Tenthredinidae) from southern Ecuador, with a new record for the country and some ecological data

Field: Agricultural and Biological Sciences (Life Sciences)

An illustrated list of species of sawflies collected during 2014 and 2015 in southern Ecuador is given. One genus and species, Pristiphora fernandezi Smith (Tenthredinidae), is new for the country. Ecological data are provided for Lagideus podocarpus Smith, sp. n. (Pergidae) that was observed feeding on Fuchsia vulcanica L. (Onagraceae). Three new combinations are proposed: Bolivius notabilis (Konow, 1899), Plaumanniana biclinea (Konow, 1899), and Proselandria alvina (Konow, 1899) (Tenthredinidae: Selandriinae). Copyright © 2016 Jean-Luc Boevé et al.
Diagnosis and treatment of chlamydia and gonorrhoea in general practice in England 2000–2011: a population-based study using data from the UK Clinical Practice Research Datalink

Field: Medicine (Health Sciences)

Objectives To determine the relative contribution of general practices (GPs) to the diagnosis of chlamydia and gonorrhoea in England and whether treatment complied with national guidelines. Design Analysis of longitudinal electronic health records in the Clinical Practice Research Datalink (CPRD) and national sexually transmitted infection (STI) surveillance databases, England, 2000–2011. Setting GPs, and community and specialist STI services. Participants Patients diagnosed with chlamydia (n=1 386 169) and gonorrhoea (n=232 720) at CPRD GPs, and community and specialist STI Services from 2000–2011. Main outcome measures Numbers and rates of chlamydia and gonorrhoea diagnoses; percentages of patients diagnosed by GPs relative to other services; percentage of GP patients treated and antimicrobials used; percentage of GP patients referred. Results The diagnosis rate (95% CI) per 100 000 population of chlamydia in GP increased from 22.8 (22.4–23.2) in 2000 to 29.3 (28.8–29.7) in 2011 (p<0.001), while the proportion treated increased from 59.5% to 78.4% (p=0.001). Over 90% were prescribed a recommended antimicrobial. Over the same period, the diagnosis rate (95% CI) per 100 000 population of gonorrhoea in GP ranged between 3.2 (3–3.3) and 2.4 (2.2–2.5; p=0.607), and the proportion treated ranged between 32.7% and 53.6% (p=0.262). Despite being discontinued as a recommended therapy for gonorrhoea in 2005, ciprofloxacin accounted for 42% of prescriptions in 2007 and 20% in 2011. Over the study period, GPs diagnosed between 9% and 16% of chlamydia cases and between 6% and 9% of gonorrhoea cases in England. Conclusions GP makes an important contribution to the diagnosis and treatment of bacterial STIs in England. While most patients diagnosed with chlamydia were managed appropriately, many of those treated for gonorrhoea received antimicrobials no longer recommended for use. Given the global threat of antimicrobial resistance, GPs should remain abreast of national treatment guidelines and alert to treatment failure in their patients.
Hearing Function among Squadron 11/Attack Helicopter Pilots in 2019–2020

Field: Health Professions (Health Sciences)

Noise-Induced Hearing Loss (NIHL) is sensorineural deafness resulting from prolonged exposure to loud noise. In the military environment, personnel with NIHL are often found. One of the professions that are at risk for NIHL is an aviator. Some of the factors that influence the degree of deafness are age and length of work. This research is a descriptive quantitative observational study with a cross-sectional design. The research subjects were Squadron 11/Attack helicopter pilots at Achmad Yani Air Base, Semarang, totaling 32 pilots, which were taken from medical record data. Sampling was done by total sampling. The data obtained were processed using SPSS and grouped into tables accompanied by descriptive explanations of each characteristic. The audiogram results showed that 32 pilots were normal, across all age and length of service categories. This result is due to the appropriate use of hearing protection device (HPD), in the form of a helmet that reduces noise up to 14 dB at 250 Hz, 21 dB at 1000 Hz, 26 dB at 2000 Hz, 37 dB at 4000 Hz, and 42 dB at a frequency of 8000 Hz, which pilots use. The pilot's working time is relatively short with a flight training schedule only 2 times a week and a flight time of around 2-3 hours. The conclusions of the study showed a description of normal hearing function in all Squadron 11/Attack helicopter pilots, based on age and length of service.
Towards a quantum ready workforce: the updated European Competence Framework for Quantum Technologies

Field: Computer Science (Physical Sciences)

The European Competence Framework for Quantum Technologies is rapidly evolving into the basic common language for educational efforts, comparison of training offerings, mapping of courses and development of educational modules. It has been compiled within the European Quantum Flagship coordination and support projects QTEdu and QUCATS. It is central, e.g., in the European Quantum Readiness Center and will be the starting point for a European certification scheme to standardise industry training. For version 2.0, released in April 2023, the framework has been updated and extended, e.g., with descriptions of the proficiency levels A1 to C2. The framework is structured into eight domains with 42 subdomains, each covering several topics and subtopics. This report briefly documents the update process and the role of the framework in quantum technology education.
3. ‘At ten minutes past two, I gazed ecstatically on both lighthouses’: Time, Self and Object in Early Romanian Travel Texts

Field: Arts and Humanities (Social Sciences)

Based on hundreds of primary sources in a wide range of languages, this book offers a reevaluation of Romanian images of self and other, as well as of foreign images of the country and people. A nuanced and historically-grounded contribution to the lively debates over Balkanism, Orientalism and identities in Romania and in Europe as a whole.
Comparative pharmacology of dothiepin, its metabolites, and other antidepressant drugs

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract The pharmacology of dothiepin and its human metabolites, northiaden, dothiepin sulfoxide, and northiaden sulfoxide, has been studied to determine whether the latter contribute to the therapeutic or side effects profile of the parent tricyclic antidepressant. In vitro, dothiepin was a potent noradrenaline and 5‐hydroxytryptamine (5‐HT) uptake inhibitor, while its secondary amine metabolite, northiaden, was selective for noradrenaline. However, the sulfoxide metabolites were almost inactive as uptake inhibitors. Dothiepin and northiaden prevented the ptosis produced by tetrabenazine in mice and reserpine in rats and increased the mobility of mice in the Porsolt test. After repeated administration, both drugs decreased β‐adrenoceptor number and stimulation of the receptor‐linked adenylate cyclase by noradrenaline. Dothiepin had a higher affinity than northiaden for histamine H 1 , muscarinic and various adrenergic and 5‐HT receptors in vitro, whereas the sulfoxide metabolites were inactive. Overall, the data indicate northiaden almost certainly contributes to the therapeutic actions of dothiepin, but the sulfoxide metabolites do not. However, the latter are also unlikely to produce any side effects. A comparison of dothiepin with other tricyclics revealed important divergences in the profiles of uptake inhibition and receptor affinity. Thus, dothiepin is generally similar to imipramine in its pharmacology, but it differs considerably from amitriptyline and doxepin. © 1992 Wiley‐Liss, Inc.
Term values of states for the lithium isoelectronic sequence

Field: Physics and Astronomy (Physical Sciences)

The nonrelativistic energies of the core-excited (n = 3, 4, 5 and 6) states for the lithium isoelectronic sequence from Li I to O VI are calculated with a full core plus correlation method using multiconfiguration wavefunctions. Relativistic and mass-polarization effects on the energy are evaluated at the first-order perturbation theory by using the Pauli-Breit operators. Our results are in close agreement with experiment and are better than other theoretical results.