jimnoneill/paper-to-field-training huggingface dataset:
Comparative Proteomics Profiling Reveals Role of Smooth Muscle Progenitors in Extracellular Matrix Production

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Objective— Recent studies on cardiovascular progenitors have led to a new appreciation that paracrine factors may support the regeneration of damaged tissues. Methods and Results— We used a shotgun proteomics strategy to compare the secretome of peripheral blood–derived smooth muscle progenitors (SPCs) with human aortic smooth muscle cells. The late-outgrowth SPCs produced fewer proteolytic enzymes and inflammatory cytokines and showed reduced invasive capacity. Similar to smooth muscle cells, SPCs secreted extracellular matrix. However, SPCs produced different matrix proteins, as evidenced by the truncation of proangiogenic domains in collagen α-1 (I) and increased production of periostin. Moreover, SPCs retained serum proteins, including proteoglycans, regulating collagen assembly; and pigment epithelium–derived factor, a potent inhibitor of angiogenesis. As a functional consequence, their conditioned medium was less angiogenic, as demonstrated by endothelial tube formation assays in vitro and implantation of Matrigel plugs into nude, severe combined immunodeficient mice (NOD/SCID). Conclusion— The present study represents an important conceptual development, suggesting that SPCs may contribute to extracellular matrix production.
Genetic Abnormalities, Melanosomal Transfer, and Degradation inside Keratinocytes Affect Skin Pigmentation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Skin pigmentation is a specific and complex mechanism that occurs as a result of the quantity and quality of melanin produced, as well as the size, number, composition, mode of transfer, distribution, and degradation of the melanosomes inside keratinocytes and the handling of the melanin product by the keratinocyte consumer. Melanocyte numbers typically remain relatively constant. Melanin synthesis, melanosome maturation, and melanoblast translocation are considered to be responsible for hereditary pigmentary disorders. Keratinocytes play a significant role in regulating the adhesion, proliferation, survival, and morphology of melanocytes. In the epidermis, each melanocyte is surrounded by 30–40 keratinocytes through dendrites and transfers mature melanosomes into the cytoplasm of keratinocytes, which are then digested. Melanocytes are believed to transfer melanosomes to neighboring keratinocytes via exocytosis-endocytosis, microvesicle shedding, phagocytosis, or the fusion of the plasma membrane, protecting skin cells against ultraviolet (UV) damage by creating a physical barrier (cap structure) over the nucleus. An understanding of the factors of melanocytes and keratinocytes that induce pigmentation and the transfer mechanism of melanosomes to keratinocytes and how genetic abnormalities in keratinocytes affect pigmentary skin disorders will help us to elucidate hereditary pigmentary disorders more transparently and provide a conceptual framework for the importance of keratinocytes in the case of pigmentary disorders.
Additional file 2 of Genome-wide identification and characterisation of Aquaporins in Nicotiana tabacum and their relationships with other Solanaceae species

Field: Agricultural and Biological Sciences (Life Sciences)

Additional file 2: Figure S1. AQP subfamily alignments for genes with incorrect protein sequences reported in Edwards et al. (2017). In red is the Edwards et al. (2017) predicted protein sequence and in black is the curated protein sequence from this study. Figure S2. Alignment of regions surrounding Histidine 207 in NtAQP1 (NtPIP1;5 s). Partial regions of a protein sequence alignment surrounding Histidine 207 of the NtAQP1 (NtPIP1;5) identified in this study, against the seemingly erroneous NtAQP1 sequence reported in (Biela et al., 1999; NCBI AF024511 and AJ001416) and closest BlastP matches from various other Solanaceae species. Figure S3. Phylogeny of Arabidopsis, tomato, rubber tree, rice, soybean and tobacco AQPs. Figure too large for this PDF; See Additional file 4. Figure S4. Phylogeny of Arabidopsis and currently identified Solanaceae AQPs. Phylogenetic trees for each AQP sub-family were generated using the neighbour-joining method from MUSCLE aligned protein sequences. Confidence levels (%) of branch points generated through bootstrapping analysis (n = 1000). Solanaceae species included in this phylogeny include; N.sylvestris (orange), N.tomentosiformis (blue), tomato (green), potato (brown) and tobacco (black). Arabidopsis genes are coloured red. Black stars indicate NtAQPs which did not have an obvious tomato ortholog. Figure S5. Sequence alignment of C-terminal tails of NtPIP and NtNIP proteins. Serine residues in red are those predicted to be phosphorylated by NetPhos 3.1 (prediction score ≥ 0.8). Underlined red serine residues in GmNOD26, SoPIP2;1 and AtPIP2;1 have been experimentally confirmed as being phosphorylated in plants. Bold residues indicate the substitution of strongly conserved positively charged Lys(K)/Arg(R) residues to a His(H) residue (blue) occurring in NtPIP1;5 and NtPIP2;1 proteins. Figure S6. Comparisons of expression profile between AQPs from tobacco (NtAQPs and NtAQPt, genes), Nicotiana sylvestris (N.syl) and Nicotiana tomentosiformis (N.tom). Correlations of relative transcript abundances was compared in two-dimensions; (i) between AQPs within a given tissue (vertically) and (ii) a given AQP across tissues (horizontally). Figure S7. Tissue-specific expression patterns of tomato XIP isoforms (SlPXIP1;1-SlXIP1;6) and the tobacco NtXIP1;7 sister genes. Comparison of relative gene expression in roots, leaves and flowers of tobacco NtXIP1;7 sister genes (blue) against all the tomato XIP isoforms (red, SlXIP1;1-SlXIP6), with potato orthologs (brown), in an attempt to find matches between the various XIPs which were difficult to assign orthology based on protein sequence alone.
Constructing A Protestant Nation

Field: Social Sciences (Social Sciences)

This article examines the recent controversy surrounding the Texas public school social studies curriculum revision process. The focus of this project is the text of the revised statewide curriculum, which offers a means of investigating the ways in which the conservative Christian authors of the new guidelines employ language to disseminate their particular worldview and propose a direction for the nation’s future. Through an analysis of the primary text, coupled with a discussion of scholarly sources, this article argues that the authors of the revised curriculum standards define American national identity as originating in Protestant Christianity, and construct a biblically-based narrative of United States history that challenges the notion of separation between church and state. The article also considers the concepts of the Judeo-Christian tradition, literalism, and American exceptionalism within the context of the curriculum guideline changes, and concludes with a discussion of Christian nationalism and fundamentalism.
From a certain desire or real need: the contexts of Jewish acculturation in Lithuania after the failure of national autonomy in 1925–1940

Field: Social Sciences (Social Sciences)

It is generally held that the failure of Jewish national autonomy in Lithuania served as an encouragement for Jewish integration and acculturation, a process that was halted by the Second World War. However there is still little research that analyses the context for a Jewish-Lithuanian mutual recognition. This article analyses Lithuanian and Jewish interactions in the cultural sphere in the years 1925–1940. It looks at a range of contacts between different Lithuanian and Jewish social groups after the failure of the national autonomy in education, the media and culture. It also reconstructs the political and ideological context, to explore the main tendencies, the motivation behind them, and their relevance and impact on Lithuania’s society.
Carbonates, Carbonation and the durability of Reinforced Concrete Marine Structures

Field: Engineering (Physical Sciences)

SummaryRecent observations derived from actual structures show that compared to other concretes, concretes containing high levels of carbonates (such as limestones and dolomites) tend to have longer reinforcement initiation times and also much longer durations before the occurrence of active corrosion causing obvious damage. This is provided that the structures do not suffer from poor workmanship, alkali reactions or other failure mechanisms. These findings are reviewed and a small number of additional examples given. The observations are consistent with careful laboratory experiments available in corrosion science literature. However, they are not consistent with the conventional wisdom that associates reinforcement corrosion initiation with the formation of calcium carbonate within the concrete matrix, such as caused by the influx of carbon dioxide from the environment. To cause initiation other processes, such as alkali leaching, must occur to lower the pH to around 8.5 or lower. Only this level of pH is consistent with electrochemistry fundamentals for initiation of steel corrosion. These observations have implications for achieving durable concrete structures.
The extention of the two classes of maximal free submonoids of the free monoid X

Field: Mathematics (Physical Sciences)

Let X~* be the free monoid generated by an alphabet X and {B_1,B_2} be an arbitrary two-partition on X,C=B_2∪B_1X~N.In [1] monoid C~* is proved to be maximal free submonoids of the free monoid,where N=1,2.In this paper,we prove that monoid C~* can also be maximal free submonoids of the free monoid X~*,where N≥3.
Integrating Pollen Analysis in Forensic Botany: Legal and Practical Recommendations for Criminal Justice in Arab Countries

Field: Social Sciences (Social Sciences)

This study explores the integration of pollen and spore analysis techniques within contemporary forensic botany to enhance criminal investigations and identify perpetrators. It underscores the significance of botanical evidence as a product of technological advancements, particularly in forensic botany. The research emphasizes the precision and reliability of botanical evidence, highlighting its superiority over traditional forms of evidence due to its longevity and resistance to tampering. Despite the absence of explicit provisions in many criminal procedural systems, the study advocates for the inclusion of pollen analysis techniques, considering their practicality, safety, and legitimacy. The study finds that botanical evidence effectively determines crime-related locations but needs additional support and safeguards. It recommends adding provisions in Arab penal laws for pollen analysis, assigning its examination to public prosecution in specific crimes, creating a national plant distribution database, and developing a legislative framework to protect individual rights while using botanical evidence in criminal justice.
Performance Evaluation of Deep Q Networks for Hybrid Reconfigurable Intelligent Surface in 6G Networks

Field: Computer Science (Physical Sciences)

The emergence of 6G wireless communication in-troduces a new era of connectivity demands, marked by high data rates and varying network conditions. To address these challenges, we propose HRISDQN, a framework that combines Hybrid Reconfigurable Intelligent Surfaces (HRIS) with Deep Q-Network (DQN)-based reinforcement learning. HRISDQN represents a significant advancement in optimising communication in 6G networks, enabling transformative improvements. In our work, we compare HRISDQN with conventional Semi Definite Relaxation (SDR), Maximum Ratio Transmission (MRT), and Minimum Mean Square Error (MMSE) as traditional beam-forming techniques. We demonstrate HRISDQN's adaptability to dynamic scenarios through extensive simulations and evaluations, including varying Signal-to-Noise Ratios (SNR) and changing user densities. Our results show that HRISDQN consistently outperforms its counterparts; HRISDQN's resource allocation capability ensures 40% better fairness, lower delay by 80%, and three times higher spectral efficiency, even in high-density user environments. The designed HRISDQN excels under diverse SNR conditions, providing robust and reliable connectivity. HRIS-DQN's exceptional performance holds great promise for the future of 6G communication. HRISDQN offers ultra-efficient, low-latency, and adaptive communication networks for augmented reality and autonomous vehicles using HRIS and DQN.
Bilateral Thalamic Infarct in Two Unresponsive Octogenarians

Field: Medicine (Health Sciences)

Bilateral thalamic infarct (BTI) represents an uncommon stroke presentation. Pathophysiology recognizes the occlusion of an anatomic variant of the thalamic blood supply from perforating branche s of posterior cerebral arteries. Presentation could be nonspecific and dramatic in the same time, being coma or stupor the possible clinical scenario encountered. Diagnosis is performed by neuroradiological imaging showing the typical bilateral paramedian thalamic infarcts. Literature lacks of evidence in very old patients, therefore we describe two cases of BTI occurred in octogenarians presenting unresponsive.BTI in very old patients presenting comatose should be taken in account as diagnostic possibili ty.
Hypovitaminosis A in extensively grazed beef cattle

Field: Veterinary (Health Sciences)

Case report Vitamin A deficiency was diagnosed in a herd of 97 19‐month‐old Braford heifers in the Mitchell Grass Downs (Astrebla spp.) bioregion of Hughenden in north‐western Queensland during November 2015. Two heifers died after a 48‐h history of sternal recumbency and of the 19 that had neurological signs, 7 were blind. Histological changes in the optic nerves of the two necropsied cattle were consistent with vitamin A deficiency. This diagnosis was supported by vitamin A concentrations in fresh liver samples of 5 and 6 mg/kg wet tissue (reference range, 100–175 mg/kg) despite treatment of the cattle with twice the recommended dose of parenteral vitamin A 3 weeks prior to sampling. Rainfall on the property during the 2 years before the outbreak was less than the annual rainfall average of 464 mm, with a total of 281 mm in 2014 and 117 mm from January to November in 2015, most of this falling in January. Conclusion Plant assays for both β‐carotene and crude protein concentrations in dry matter ( DM ) were less than the recommended dietary requirements for beef cattle (0.30 mg/kg DM and 56 g/kg, respectively).
PERAN PENTING OPTIMALISASI KINERJA SDM TERINTEGRASI TERHADAP COMPETITIVE SUSTAINABILITY TOURISM PADA UMKM SEKTOR PARIWISATA DI JAWA TIMUR

Field: Business, Management and Accounting (Social Sciences)

This research is a holistic interdependency and integrated in human resource strategy \ndesign and marketing strategy theory. This study is a development of research results \nHermawati and Puji Suci (2017) strategy of organizational performance development \nbased on method of Importance Performance Analysis and Analytic Hierarcical Process \n(AHP). The purpose of this study examines the influence and obtain empirical evidence, \nanalyze, and explain the extent to which aspects of integrated human resources \nfunction in optimizing the performance of SMEs Tourism sector for sustainable tourism \ncompetitiveness in East Java. Research method with, quantitative and qualitative \napproach. The sampling technique is purposive sampling. The study involved 200 \nemployees of tourism sector SMEs. The analytical tool used is, GSCA with Sobel Test \napproach. Result of research, there is contribution which mean Integrated Human \nResource Performance to SMEs Tourism Human Resource. That is, the higher the \nPerformance of Integrated HR, will result in the higher Performance of SMEs Tourism HR. \nKeywords : QWL, OCB, Integrated HR, Human Resource Performance, Tourism Competitiveness Sustained
The MDM2 oncoprotein is overexpressed in rhabdomyosarcoma cell lines and stabilizes wild-type p53 protein.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

MDM2 gene overexpression has been implicated in the pathogenesis of human neoplasia via inhibition of the p53 tumor-suppressor function. To investigate the potential involvement of the MDM2 oncogene in the pathogenesis of childhood rhabdomyosarcoma (RMS) we studied MDM2 abnormalities in six RMS cell lines in correlation with the p53 status. Three showed overexpression of MDM2 mRNA and protein, one with concomitant MDM2 gene amplification. All three lacked p53 mutation and expressed low levels of p53 mRNA but exhibited elevated p53 proteins. Double immunostaining revealed that the overexpressed MDM2 and p53 proteins were co-localized to the same cell nuclei. Furthermore, the two proteins were physically associated, as shown by co-immunoprecipitation and Western blot analysis. The half-life of the p53 protein was prolonged in the MDM2-expressing RMS cells. The extended half-life wildtype p53 protein and its complex formation with the elevated MDM2 suggest that the underlying mechanism for p53 protein accumulation in these cell lines is p53 stabilization by an overabundant MDM2 protein. The overexpressed MDM2 protein had a short half-life. The three remaining RMS cell lines exhibited low MDM2 mRNA and protein levels and carried p53 mutations. This study suggest that MDM2 overexpression represents an alternative mechanism for p53 inactivation in a subset of childhood RMS without p53 mutations. The results further indicate that the elevated MDM2 protein is responsible for wildtype p53 protein accumulation via stabilization.
IMPLEMENTATION OF THE DECREE OF KABANJAHE GENERAL HOSPITAL DIRECTOR CONCERNING NON-SMOKING AREA

Field: Health Professions (Health Sciences)

Background: The case of smoking today becomes a big problem which can cause death in Indonesia. Law /No. 44/2009 on Hospital require hospital management impose a regulation that all areas of a hospital have to be KTR (No Smoking Area). Kabanjahe Regional General Hospital has implemented the policy of KTR according to the SK (Directive) of the Hospital which has not been implemented completely so far. The objective of this research was to analyze the implementation of SK Director RSU Kabanjahe No. 1255/RSU/2016 About KTR at RSU Kabanjahe in 201 7. Metode: This research used qualitative method with interview technique, participant observation, documentation and triangulation with sample consisting of 4 employees and 2 patients of Kabanjahe Hospital and using note book instrument, tape recorder, camera and researcher as instrument. The belief in the results of the research is done by testing the credibility, depenability, process and research results. The research was conducted in RSUD Kabanjahe. Result: The result of the research showed that the implementation of KTR at RSU Kabanjahe did not run well although it had been implemented for eight years. It was caused by some inhibiting factors such as some of its managers and the personnel still smoked, there was no Regional Regulation which regulated it, there was the lack of commitment of the Director in imposing sanction and in establishing a supervisory committee for KTR. Conclusion: The implementation of KTR at Kabanjahe Hospital was not in accordance with the Directive of the Director of the hospital or failed. It is recommended that the hospital management increase disposition , and bureaucratic structure in supporting the policy on KTR . Keywords: non smoking area, implementation, hospital DOI: https://doi.org/10.26553/jikm.2018.9.1.64-73
Editorial [Hot Topic: Replicating Strand Asymmetry in Bacterial and Eukaryotic Genomes (Guest Editor: Feng-Biao Guo)]

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

It is my pleasure as a Guest Editor of Current Genomics to present you with a 'hot topic issue' on DNA replication.DNA replication adopts a set of asymmetric mechanisms.One of them is the division of leading and lagging strands.In
Online Social Learning and Instructional Presence: Enhancing English Education at a Jordanian University

Field: Social Sciences (Social Sciences)

Due to the rapid growth of online education, universities have maximised their English language learning experiences. This study explores English language learning communities in synchronous and asynchronous online contexts, focusing on social and instructional presence. The sample included 10 English language, literature, and translation students. Open-ended questions were asked in a small focus group to promote reflective conversation. The intricacies of social and instructional presence in online learning are made clear by this qualitative method. By concentrating on the complex relationships and common perspectives that emerge in targeted group discussions, the study revealed how students view their interaction with social and instructional presence to enhance English language instruction in the digital environment. The study offers important information for customising approaches used at the university. Combining these strategies may enhance virtual learning environments, mainly the English language courses offered by the university.
Hierarchical spectrum sharing in cognitive radio communications

Field: Computer Science (Physical Sciences)

DOI: 10.1049/cp:20061397 ISBN: 0 86341 644 6 Location: Hangzhou, China Conference date: 6-9 Nov. 2006 Format: PDF In this paper, according to the interference temperature model and channel conditions, we classify available bands, on which cognitive radios are capable of sharing with legacy systems, into two types-TYPE I used for direct communication between cognitive radio service access point (CR-SAP) and cognitive radio base station (CR-BS), and TYPE II used for direct communication between CR-SAP and its neighbor CR-SAPs. We name this classification as hierarchical spectrum sharing (HSS) and propose an identification process. Four kinds of communication scheme are designed based on HSS so that the cognitive radio can adapt to different transmission requirements. Numerical results show that HSS provides a considerable extension to available bands so that the spectral utility may be improved further. (4 pages) Inspec keywords: wireless channels; cognitive radio; spectral analysis; radiofrequency interference Subjects: Radio links and equipment; Electromagnetic compatibility and interference
Social Media: The New Mantra for Managing Reputation

Field: Business, Management and Accounting (Social Sciences)

Apology; Authenticity; Blurred Boundaries; Corporate Communication; Corporate Reputation; Corporate Social; Responsibility (CSR); Crisis Communication; Crisis Messaging; CSR Reputation; Digital; Employee Relations; Hoax; Leadership; Organizational Values; Public Relations; Reputational Messages; Social Media; Social Media Monitoring; Social Networks; Stakeholder Engagement; Transparency; Trust; Workplace Surveillance