jimnoneill/paper-to-field-training huggingface dataset:
Oocyte maturation arrest produced by TUBB8 mutations: impact of genetic disorders in infertility treatment

Field: Medicine (Health Sciences)

Oocyte maturation defect is a challenging situation in the management of infertility, the etiology may be related to endocrine causes, protocols used in ovarian stimulation, oocyte intrinsic defects or procedures in embryology laboratory. We report three Mexican females in treatment for primary infertility with non-mature oocytes after ovary stimulation and oocyte capture in whom a genetic diagnosis of TUBB8-oocyte maturation defect was revealed by exome sequencing. Two couples achieved pregnancies though oocyte donation after establishing the genetic etiology. Our results expand the role of TUBB8-disorders in patients of non-Asian ethnicity. Oocyte maturation defects of monogenic origin are a growing group of disorders that endocrinologists and reproductive medicine specialists should be aware in order to provide referral to genetics for establish a correct and opportune diagnosis.
Context-aware self-optimization in small-cell networks

Field: Computer Science (Physical Sciences)

Most mobile communications take place at indoor environments, especially in commercial and corporate scenarios. These places normally present coverage and capacity issues due to the poor signal quality, which degrade the end-user Quality of Experience (QoE). In these cases, mobile operators are offering small cells to overcome the indoor issues, being femtocells the main deployed base stations.Femtocell networks provide significant benefits to mobile operators and their clients. However, the massive integration and the particularities of femtocells, make the maintenance of these infrastructures a challenge for engineers. In this sense, Self-Organizing Networks (SON) techniques play an important role. These techniques are a key feature to intelligently automate network operation, administration and management procedures.SON mechanisms are based on the analysis of the mobile network alarms, counters and indicators. In parallel, electronics, sensors and software applications evolve rapidly and are everywhere. Thanks to this, valuable context information can be gathered, which properly managed can improve SON techniques performance. Within possible context data, one of the most active topics is the indoor positioning due to the immediate interest on indoor location-based services (LBS).At indoor commercial and corporate environments, user densities and traffic vary in spatial and temporal domain. These situations lead to degrade cellular network performance, being temporary traffic fluctuations and focused congestions one of the most common issues. Load balancing techniques, which have been identified as a use case in self-optimization paradigm for Long Term Evolution (LTE), can alleviate these congestion problems. This use case has been widely studied in macrocellular networks and outdoor scenarios. However, the particularities of femtocells, the characteristics of indoor scenarios and the influence of users’ mobility pattern justify the development of new solutions.The goal of this PhD thesis is to design and develop novel and automatic solutions for temporary traffic fluctuations and focused network congestion issues in commercial and corporate femtocell environments. For that purpose, the implementation of an efficient management architecture to integrate context data into the mobile network and SON mechanisms is required. Afterwards, an accurate indoor positioning system is developed, as a possible inexpensive solution for context-aware SON. Finally, advanced self-optimization methods to shift users from overloaded cells to other cells with spare resources are designed. These methods tune femtocell configuration parameters based on network information, such as ratio of active users, and context information, such as users’ position. All these methods are evaluated in both a dynamic LTE system-level simulator and in a field-trial.
Early pancreas allograft thrombosis

Field: Medicine (Health Sciences)

Abstract Objectives To determine factors associated with early pancreatic allograft thrombosis ( EPAT ). Thrombosis is the leading non‐immunological cause of early pancreatic allograft failure. Multiple risk factors have been postulated. We hypothesized that recipient perioperative hypotension was a major risk factor and evaluated the correlation of this and other parameters with EPAT . Methods We retrospectively reviewed the records of the 118 patients who received a pancreatic allograft at our center between October 1992 and January 2010. Multiple donor and recipient parameters were analyzed as associates of EPAT by univariate and multivariate analysis. Results There were 12 episodes of EPAT , resulting in an incidence of 10.2%. On univariate analysis, EPAT was associated with perioperative hypotension, vasopressor use, and neuropathy in the recipient (p ≤ 0.04 for all). On multivariate analysis corrected for age, sex, and peripheral vascular disease, only vasopressor use retained a significant association with EPAT with a hazard ratio of 8.74 ( CI 1.11–68.9, p = 0.04). Factors associated with vasopressor use included recipient ischemic heart disease, peripheral vascular disease, retinopathy or neuropathy, and any surgical complication. Conclusions Significant hypotension, measured by the need for perioperative vasopressor use was associated with EPAT , suggesting that maintenance of higher perfusion pressures may avoid this complication.
Metagenomic Analysis of Rhizosphere Bacteria in Desert Plant Calotropis procera

Field: Agricultural and Biological Sciences (Life Sciences)

The microbial community of complex association of plant is vital for the health of the plant. Plants able to form the microbiome of their rhizosphere as the new advanced research in plant-microbe interaction is revealed. Also, the recent research suggested the fact that the microbial communities help some desert plants in drought tolerance by microbial water production. This study focused on the characterization of rhizosphere bacteria of desert plant Calotropis procera to investigate the relationship between this plant and its rhizosphere microbial communities. The study was achieved via deep sequencing of the V3–V4 regions (∼415 bp) of bacterial 16S rRNA. A total of 2173 operational taxonomic units (OTUs) were assigned sequence tags across samples with at least 97% similarity. A total of 24 OUT is selected with cutoff 1000 abundance. The results showed that the most popular phyla are Acidobacteria (two genera), Actinobacteria (fourteen genera), Bacteroidetes (one genus), Proteobacteria (6 genera), and Firmicutes (nine genera). Highly abundant genera included Ammoniphilus, Bacillus, Iamia (which reported for a first time in soil), Microvirga, Nocardia, Streptomyces, Defluviicoccus, Mycobacterium, Nocardioides, Sphingomonas, Bryobacter, Ammoniphilus, Stenotrophobacter, Arthrobacter, Actinomadura, and Marmoricola. At the species level, high abundance of Nocardia cyriacigeorgica, Rhodospirillales bacterium WX36, and Arthrobacter crystallopoietes in C. procera rhizosphere. These results show that there are at least 20 unknown species (identified at genus or family levels) in C. procera rhizosphere which are not found in rhizosphere free plants.
PEACE EDUCATION AND THE TEACHING OF HISTORY.

Field: Arts and Humanities (Social Sciences)

This essay examines the possibilities for peace education through the teaching of history, with a specific focus on the Queensland Senior Modern History Curriculum. An examination is made of the major themes within the Curriculum, namely, nationalism, internationalism, economic history, Asian and Australian history, imperialism, neo-imperialism, racism, and recent social and cultural history, and within each of these it is argued that there are substantive possibilities for teaching the value of peace. Essay
APPARATUS FOR AUTOMATIC RECORDING OF THE ARTERIAL BLOOD PRESSURE,

Field: Medicine (Health Sciences)

An apparatus for the automatical recording of the arterial blood pressure is described. It consists of a pressure cuff which fastens to the shoulder of the test subject, a balloon with compressed air, and a miniature source of electric power supply. An automatic pressure device in the form of a spasmodic pneumatic switch is set in motion by means of a miniature sylphon with an electric contact in the transmitter circuit, accomplishing a periodic variation of air pressure in the pneumatic system for compressing the blood vessels. The apparatus is different in that the recording of the pulse oscillations is accomplished by means of a thermo-anomometer transmitter, the output of which is switched onto a recording oscillograph.
Enhancing the nutritional quality and digestibility of citronella waste (Cymbopogon nardus) for ruminant feed through ammoniation and fermentation techniques

Field: Agricultural and Biological Sciences (Life Sciences)

Background and Aim: Citronella grass (Cymbopogon nardus) waste, produced by distilling citronella to produce essential oil, has a high potential for use as animal feed. However, the presence of high lignin content could limit its digestibility, prompting the need for treatment to improve its quality. This study aimed to improve the nutritional value and in vitro digestibility of ammoniated and fermented citronella waste (CW). Materials and Methods: The treatments of CW included CW without treatment as a control (T0), ammoniation of CW with urea (T1), fermentation of CW with Trichoderma harzianum (T2), and a combination of ammoniation and fermentation (amofer) of CW (T3). This study employed a randomized block design with five replicates for each of the four treatments. If there was a significant effect (p < 0.05), a post hoc Duncan’s multiple range test was performed to analyze the variance of the data. Results: The process of ammoniation and fermentation led to a notable increase in crude protein (2%–6%) while decreasing crude fiber (2%–6%), neutral detergent fiber (NDF) (5%–14%), acid detergent fiber (ADF) (5%–9%), lignin (4%–9%), and cellulose (2%–10%). The treatments enhanced the digestibility of dry matter, organic matter (OM), NH3, and total volatile fatty acid by 4%–12%, 6%–19%, 0.9–10 mM, and 35–142 mM, respectively. The decrease in NDF, ADF, acid detergent lignin (ADL), and cellulose fractions was accompanied by an improvement in dry matter and OM digestibility in CW. Ammoniated-fermented (amofer) CW, followed by fermentation with T. harzianum and ammoniated urea treatment, significantly enhanced the nutritional content and in vitro digestibility. The decrease in NDF, ADF, ADL, and cellulose fractions led to an improvement in dry matter and OM digestibility in CW. Conclusion: The application of amofer treatment with T. harzianum maximizes CW’s nutritional value and digestibility, making it the most efficient preservation method. Research is needed to explore the potential use of Aspergillus spp. and Pleurotus spp. for fermenting CW as ruminant fodder. Keywords: ammoniation, Cymbopogon nardus, digestibility, fermentation, Trichoderma harzianum.
South‐South dialogue

Field: Arts and Humanities (Social Sciences)

Since feminism is an ongoing process of practices and theorizing that unveils the complexity of the “subject” of feminism, in this essay I focus on Latin American genealogies and legacies. In the first part, I follow the anarchist, socialist and liberal roots of Latin American feminism. The 70s and 80s are marked by the processes of the radical left and repressive dictatorships. In the 90s we follow democratization with ONGisation, and what I call the de-centering of “illustrated” Latin American feminism and its process of multiethnic feminisms.
Description of nine species of the genus Bembecinus A. COSTA, 1859 and revision of the B. acanthomerus species group (Hymenoptera, Spheciformes)

Field: Agricultural and Biological Sciences (Life Sciences)

Schmid, Christian (2024): Description of nine species of the genus Bembecinus A. COSTA, 1859 and revision of the B. acanthomerus species group (Hymenoptera, Spheciformes). Linzer biologische Beiträge 56 (1): 313-336, DOI: 10.5281/zenodo.14681733
The role of inactivation in the effects of n‐alkanols on the sodium current of cultured rat sensory neurones.

Field: Neuroscience (Life Sciences)

1. The whole‐cell patch‐clamp technique has been used to investigate the actions of n‐butanol, n‐pentanol, n‐hexanol and n‐octanol on the sodium current of cells isolated from the dorsal root ganglia (DRGs) of neonatal rats and maintained in short‐term tissue culture. 2. The influence of n‐alkanols on the level of steady‐state inactivation of the sodium current was investigated by a standard two‐pulse protocol. All alkanols increased the level of resting inactivation and this was manifested as a hyperpolarizing shift of the relationship between the steady‐state inactivation parameter (h infinity) and membrane potential. The mid‐point of the h infinity curve was moved by up to ‐30 mV. 3. The relationship between the shift in the mid‐point of the inactivation curve (delta Vh) and aqueous n‐alkanol concentration has been derived for each n‐alkanol. These are complex in shape and do not appear consistent with a hypothesis that the increase in inactivation results from 1:1 binding of an alkanol molecule to a single site on the channel protein. 4. The aqueous concentrations used ranged from 70 mM‐n‐butanol to 0.05 mM‐n‐octanol. However, equal fractional saturations of n‐alkanols produced approximately equal shifts in the h infinity curve, particularly in the range 0.01‐0.07 saturated. This implies a hydrophobic site of action, with a standard free energy per methylene group for adsorption to the site from the aqueous phase of ca ‐3.2 kJ/mol. 5. The increase in resting inactivation was not the sole means by which n‐alkanols reduced the sodium current. The current was still reduced in cells pre‐pulsed to sufficiently negative potentials to remove steady‐state inactivation even in the presence of alkanols. The concentration required to reduce the current by 50% (ED50) has been interpolated for each n‐alkanol. From these data it was estimated that the standard free energy per methylene group for adsorption to the site of action was ca ‐3.1 kJ/mol, similar to that calculated for the effect on inactivation. The concentration dependence of this residual block indicated the involvement of more than one n‐alkanol molecule. 6. The n‐alkanols increase the level of inactivation of rat DRG cell sodium channels at potentials around the resting membrane potential and this effect contributes to their local anaesthetic action.(ABSTRACT TRUNCATED AT 400 WORDS)
Using Market Basket Analysis in Management Research

Field: Decision Sciences (Social Sciences)

Market basket analysis (MBA), also known as association rule mining or affinity analysis, is a data-mining technique that originated in the field of marketing and more recently has been used effectively in other fields, such as bioinformatics, nuclear science, pharmacoepidemiology, immunology, and geophysics. The goal of MBA is to identify relationships (i.e., association rules) between groups of products, items, or categories. We describe MBA and explain that it allows for inductive theorizing; can address contingency (i.e., moderated) relationships; does not rely on assumptions such as linearity, normality, and residual equal variance, which are often violated when using general linear model–based techniques; allows for the use of data often considered “unusable” and “messy” in management research (e.g., data not collected specifically for research purposes); can help build dynamic theories (i.e., theories that consider the role of time explicitly); is suited to examine relationships across levels of analysis; and is practitioner friendly. We explain how the adoption of MBA is likely to help bridge the much-lamented micro–macro and science–practice divides. We also illustrate that use of MBA can lead to insights in substantive management domains, such as human resource management (e.g., employee benefits), organizational behavior (e.g., dysfunctional employee behavior), entrepreneurship (e.g., entrepreneurs’ identities), and strategic management (e.g., corporate social responsibility). We hope our article will serve as a catalyst for the adoption of MBA as a novel methodological approach in management research.
An interface griffith crack in coated fiber reinforced composite materials

Field: Engineering (Physical Sciences)

The Griffith interface crack with a circular inclusion is investigated in this study. The study will utilize the theory of linear elastic fracture mechanics and practical verification of finite element methods to determine the stress intensity factors of a composite material under uniaxial far-field loading. Finite element methods will be used in the study to obtain results which will be compared against current analytical work to detemine its accuracy. As the de-bonding angle increases, the stress intensity factors approach zero or a negative number where the experiment will cease. The de-bonding angle and the Young's modulus will be varied to check its influence on the stress intensity factors as well as the accuracy of the model to be able to obtain accurate results when the materials are non-homogenous. The study also included the expansion of a two-phase model with an additional layer of coating. The coating problem was simplified with assumptions to successfully model a two-phase interface crack problem. Further, the three-phase model was studied based on the expansion of the two-phase model with coating to determine the stress intensity factors around the crack tip and crack propagation.
Effective nursing shift handover in critical care: A concept analysis

Field: Nursing (Health Sciences)

To explore the concept of effective shift handover in critical care settings. Ineffective handover is one of the leading causes of adverse events in healthcare settings. Nursing shift handover in the intensive care unit (ICU) is more complex and detailed than in other in-patient wards due to the complexity of medical issues experienced by ICU patients. It is, therefore, critical that nurses be able to conduct handover effectively. Despite the importance of handover, the definition and attributes of effective handover are not clearly understood. Walker and Avant's eight-step approach to concept analysis. Effective handover in nursing is an interactive process between two nurses, resulting in the direct transfer of adequate patient-specific recent information in a manner that creates a shared understanding of information. Its defining attributes are (1) content-related and (2) process-related attributes. The antecedents of effective handover are organizational support, interpersonal relationship, and work environment. Its consequences include patient and nurse satisfaction, improved care, and continuity of care. Empirical referents include several tools developed to measure some of the effective handover attributes. The definition provides a connotative meaning and is the first step toward concept validation and instrument development to measure effective handover practice in the ICU.
Pharmacokinetics of Hydrogen During Hydrogen-Saturated Saline Infusion in Pigs

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background: Hydrogen gas (H2) has been shown to be effective in the treatment of various clinical conditions, from acute illnesses to chronic illnesses. However, its clinical indications and the corresponding appropriate hydrogen delivery methods have yet to be determined. This is due to the fact that the pharmacokinetics and pharmacodynamics of hydrogen in each delivery method have not been experimentally proven. Here, we verified the pharmacokinetics of hydrogen after the infusion of hydrogen-saturated saline. Methods: Hydrogen-saturated saline was prepared and checked for sterility and component specifications. Hydrogen-saturated saline was administered intravenously (125 mL/h) through the left internal jugular vein of pigs, and the blood hydrogen concentration was measured over time. Results: It was confirmed that hydrogen can be safely mixed under pressure into intravenous solutions (pharmaceutical products) without the contamination of foreign substances by using a needle-less vial access cannula. No change in the PH or composition of the solution was observed due to hydrogen filling. The hydrogen concentrations of blood samples collected from the left internal jugular vein 3 cm to the heart from the tip of the infusion line were 6.4 (30 min), 4.7 (60 min), 4.9 (90 min), and 5.3 (120 min) ppb w/w, respectively. The hydrogen concentrations of blood samples collected from the right atrium were 0.7 (30 min), 0.5 (60 min), 0.7 (90 min), and 0.7 (120 min) ppb, respectively. The hydrogen concentration of blood samples collected from the right internal carotid artery were 0.1 (pre), 0.2 (30 min), 0.3 (60 min), 0.0 (90 min), and 0.0 (120 min) ppb w/w, respectively. Conclusions: We confirmed that hydrogen could be safely pressurized and filled into intravenous (pharmaceutical) solution without contamination by foreign objects using a needle-free vial access cannula. When saturated hydrogen saline was dripped intravenously, almost all of the hydrogen was expelled during its passage through the lungs and could not be supplied to the arterial side.
Assessment of kinematic concepts comprehension: A systematic review

Field: Social Sciences (Social Sciences)

<span lang="EN-US">A systematic study on the development of the assessment instrument of the concept of kinematics which is one of the basic concepts of physics has not yet been conducted. This systematic study reported the characteristics, quality, effectiveness, and efficiency of the instrument assessment regarding the concept of kinematics. This systematic review method has used a systematic approach based on the practical guidelines of systematic reviews by Petticrew and Roberts and has used PRISMA diagrams for the process of searching and selecting articles, who reviewed 12 articles published between 1985 and 2021. The research findings show that the instrument of concept mastery of kinematics using multiple-choice formats, while others combine the true-false and multiple-choice formats. Almost all instruments of mastery of the concept of widely used kinematics have reported validity assessment (content validity, construct validity) and internal consistency reliability. However, predictive validity, discriminatory validity, and temporal stability reliability have not been reported. Other results indicate that the development of further assessments must pay attention to five important aspects: the validity and reliability of instruments, the scopes and specificity of the concept of kinematics, the conformity with the intellectual level of students, the effectiveness and efficiency of instrument assessment, and the fulfillment of research gaps. This study can help educators and researchers choose and develop an appropriate instrument assessment to reveal students’ understanding of the concept of kinematics.</span>