jimnoneill/paper-to-field-training huggingface dataset:
Abstract 149: Differences In Self-reported Health Status Among Underrepresented Populations In Stroke Survivors Enrolled In All Of Us

Field: Medicine (Health Sciences)

Background: Self-reported outcomes in stroke survivors remain understudied. Mounting evidence indicate that the burden of stroke is disproportionately high in underrepresented groups. We investigated differences in self-perceived health status in stroke survivors across broadly defined underrepresented minorities. Methods: We analyzed data from stroke survivors enrolled in All of Us. Ischemic and hemorrhagic stroke were defined using validated ICD10 codes. Self-perceived health status was evaluated using 5 domains (quality of life, physical health, mental health, social activities and overall health), each with 5 answers (excellent, very good, good, fair and poor). Each domain was dichotomized as favorable (excellent, very good or good) or unfavorable (fair/poor). We used multivariate logistic regression to model the odds of favorable self-perceived health status in underrepresented groups defined by race/ethnicity, education, income and insurance type. Results: 6,977 stroke survivors were included (mean age 64, female sex 58%), including 1,623 (23.3%) Blacks, 856 (12.3%) Hispanics/Latinos, 654 (9.4%) with less than a high school degree, 2,679 (38.4%) with income <U$S 35k, 3,091 (44.3%) with Medicare/Medicaid and 13 (0.18%) uninsured. A number of underrepresented groups had significantly different self-perceived health status after stroke (Table): low income, limited education and Medicare/Medicaid insurance were associated with self-perceived unfavorable health status in all 5 domains (all results with 95%CI <1). Conclusion: Among stroke survivors, underrepresented groups defined by income, education and health insurance were more likely to perceive their health status as unfavorable. Evaluation of underrepresented groups defined by factors other than race/ethnicity was important to identify these differences. Further research should evaluate whether these differences correlate with objectively measured outcome measures.
Geraniales (Geranium)

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract The angiosperm order Geraniales, as currently informally recognized, contains about 800 species, some of which are of economical and horticultural importance. Geraniales mainly comprises three families: Geraniaceae (geraniums, pelargoniums), Melianthaceae, a family of 18 species, Ledocarpaceae totalling 12 species in three genera, and Vivianiaceae, a small family containing a single genus with six species.
IMMUNOBIOLOGY Switch in the protein tyrosine phosphatase associated with human CD100 semaphorin at terminal B-cell differentiation stage

Field: Immunology and Microbiology (Life Sciences)

Human CD100, the first semaphorin iden-tified in the immune system, is a trans-membrane protein involved in T-cell acti-vation. In the present study, we showed that activation of peripheral blood or tonsillar B lymphocytes induced the ex-pression of CD100 in CD381CD1382 cell populations, including in CD1481 sub-populations, thus expressing a memory B-cell–like phenotype. Using an in vitro enzymatic assay, we found that protein tyrosine phosphatase (PTP) activities were immunoprecipitated with CD100 in these cell populations, which were iso-lated by cell sorting, as well as in most B-cell lines representing various stages of B-cell differentiation. Immunodepletion and Western blotting experiments demon-strated that CD45 was the PTP associated with CD100 in cell lines displaying pre-B, activated B, and pre-plasma cell pheno-types. CD45 also accounted for PTP activity immunoprecipitated with CD100 in CD381CD1382 cells sorted after activa-tion of peripheral blood or tonsillar B lymphocytes. In contrast, no CD100-CD45 association was observed in plasma cell lines corresponding to the terminal B-cell differentiation stage. CD148, the other transmembrane PTP known to be implicated in lymphocyte signaling path-ways, was either only partly involved in the CD100-associated PTP activity or not expressed in plasma cell lines, indicating the association of CD100 with another main PTP. Our data show that CD100 is differentially expressed and can function-ally associate with distinct PTPs in B cells depending on their activation and maturation state. They also provide evi-dence for a switch in the CD100-associ-ated PTP at terminal stage of B-cell differentiation. (Blood. 2000;95:965-972) r 2000 by The American Society of Hematology
QUALITATIVE FACTORS THAT IMPACT REAL IMPLEMENTING VOIP IN PRIVATE NETWORKS

Field: Engineering (Physical Sciences)

Integrating enterprise voice services on a data network can offer significant capital and operational cost reductions, and can enable new competitive services. However, if these business values are to be realized, customers must be won and retained by meeting their expectations for service quality. In networking, quality can mean many things. In VoIP, quality simply means being able to listen and speak in a clear and continuous voice, without unwanted noise. Quality depends mainly on the following factors: data loss, consistent delay characteristics (called jitter) and latency, leading to echo. QoS (Quality of Service) is more in demand on corporate LANs, private networks and intranets (private networks interconnecting parts of organizations) than on the Internet and ISP networks. QoS, reliability and security are an important tools for VoIP success. Call quality testing has traditionally been subjective: picking up a telephone and listening to the quality of the voice. The leading subjective measurement of voice quality is the MOS (mean opinion score) as described in the ITU (International Telecommunications Union) recommendation P.800. Considerable progress has been made in establishing objective measurements of call quality on example the E-model (ITU G.107).
Studies in the Synthesis of Coumarino-α-pyrones and Furocoumarins; Part XIX*. Synthesis of 4-Hydroxy-3-phenyl-5', 8-dimethylpsoralene.

Field: Chemistry (Physical Sciences)

Chemistry Department, Faculty of Science, M. S. University of Baroda, Baroda. Manuscript received 5 July 1972 ; revised 10 September 1974 ; accepted 12 September 1974 2,4-Dihydroxy-3-methyl-ω-phenyl acetophenone on allylation gave 4-allyloxy derivative, which on condensation with diethyl carbonate furnished 4-hydroxy-3-phenyl-7-allyloxy-8-methylcoumarin (Ia). Methylation, followed by Claisen rearrangement of (Ia) gave the corresponding 6-allyl compound, which on cyclisation followed by dehydrogenation gave 4-methoxy- and 4-hydroxy-3- phenyl-5', 8-dimethylpsoralene.
Acoustic Streaming via a Flexible PCB for Micropumping Applications

Field: Engineering (Physical Sciences)

We present a microfluidic device for moving a fluid in a ring-shaped channel that utilizes boundary layer driven acoustic streaming as its driving mechanism. One wall of the channel is made of a flexible material and acts as the acoustic source. To help in the design process, a numerical study based on perturbation theory was conducted. A flexible printed circuit board is used as an actuator, which is excited magnetically using Lorentz forces to introduce a flexural travelling wave. The resulting streaming velocity is measured using particle tracking velocimetry and its dependence on the deflection amplitude is identified to verify the numerical results.
Probing sensorimotor integration during musical performance

Field: Neuroscience (Life Sciences)

Abstract An integration of afferent sensory information from the visual, auditory, and proprioceptive systems into execution and update of motor programs plays crucial roles in control and acquisition of skillful sequential movements in musical performance. However, conventional behavioral and neurophysiological techniques that have been applied to study simplistic motor behaviors limit elucidating online sensorimotor integration processes underlying skillful musical performance. Here, we propose two novel techniques that were developed to investigate the roles of auditory and proprioceptive feedback in piano performance. First, a closed‐loop noninvasive brain stimulation system that consists of transcranial magnetic stimulation, a motion sensor, and a microcomputer enabled to assess time‐varying cortical processes subserving auditory–motor integration during piano playing. Second, a force‐field system capable of manipulating the weight of a piano key allowed for characterizing movement adaptation based on the feedback obtained, which can shed light on the formation of an internal representation of the piano. Results of neurophysiological and psychophysics experiments provided evidence validating these systems as effective means for disentangling computational and neural processes of sensorimotor integration in musical performance.
The influence of infectious disease on ventricular evoked responses from heart transplants

Field: Medicine (Health Sciences)

Telemetric recording and subsequent analysis of intramyocardial electrograms offer a noninvasive method for patient monitoring after heart transplantation. Decreasing electrical activity indicates both episodes of rejection and infection. Analysis of the duration of the ventricular evoked response recorded during pacing reveals a significant increase of this parameter only during infection. In many cases, this additional information can be used to differentiate between the two pathological effects and to enhance the specificity of the method.
Practical Application of a Positive Resistance Up-Converter for Ultra-Low-Noise Amplification

Field: Physics and Astronomy (Physical Sciences)

An ultra-low-noise, tunable s-band amplifier which uses a travelling-wave maser (TWM) as the second stage has been developed. The amplifier is made up of a cooled, tunable low-noise s-band varactor up-converter, a fixed-tuned, high-gain, C-band TWM, and an uncooled, tunable varactor down-converter connected in cascade. This receiver configuration has the advantage of combining the large tuning range capability of a parametric up-converter with the ultra-low noise temperature and unconditional stability of a maser.
Data from The Tyrosine Kinase Inhibitor Imatinib Augments Extracellular Fluid Exchange and Reduces Average Collagen Fibril Diameter in Experimental Carcinoma

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

<div>Abstract<p>A typical obstacle to cancer therapy is the limited distribution of low molecular weight anticancer drugs within the carcinoma tissue. In experimental carcinoma, imatinib (STI571) increases efficacy of synchronized chemotherapy, reduces tumor interstitial fluid pressure, and increases interstitial fluid volume. STI571 also increases the water-perfusable fraction in metastases from human colorectal adenocarcinomas. Because the mechanism(s) behind these effects have not been fully elucidated, we investigated the hypothesis that STI571 alters specific properties of the stromal extracellular matrix. We analyzed STI571-treated human colorectal KAT-4/HT-29 experimental carcinomas, known to have a well-developed stromal compartment, for solute exchange and glycosaminoglycan content, as well as collagen content, structure, and synthesis. MRI of STI571-treated KAT-4/HT-29 experimental carcinomas showed a significantly increased efficacy in dynamic exchanges of solutes between tumor interstitium and blood. This effect was paralleled by a distinct change of the stromal collagen network architecture, manifested by a decreased average collagen fibril diameter, and increased collagen turnover. The glycosaminoglycan content was unchanged. Furthermore, the apparent effects on the stromal cellular composition were limited to a reduction in an NG2-positive stromal cell population. The current data support the hypothesis that the collagen network architecture influences the dynamic exchanges of solutes between blood and carcinoma tissue. It is conceivable that STI571 reprograms distinct nonvascular stromal cells to produce a looser extracellular matrix, ultimately improving transport characteristics for traditional chemotherapeutic agents. <i>Mol Cancer Ther; 15(10); 2455–64. ©2016 AACR</i>.</p></div>
Total Kjeldahl-N, Nitrate-N, C/N Ratio and pH Improvements in

Field: Agricultural and Biological Sciences (Life Sciences)

The study investigated improvements of composting blended feedstock of T. diversifolia and maize stalks on total Kjeldahl-N (TKN), nitrate-N, C/N ratios and pH of chimato Composts. In this study, T. diversifolia/maize stalks (Td: MS) ratios: 0:100, 25:80, 20:80, 40:60, 50:50, 60:40, 75:25, 80:20 and 100:0 (v/v) were prepared and then composted using chimato composting technology. The TKN and organic carbon, nitrate-N, C/N ratios and pH were determined using standard methods. Results showed significantly higher TKN and nitrate-N and lower final C/N ratios in chimato composts produced using T. diversifolia blending ratios of above 40 % than those below (0% (p&lt;0.001, α=0.01), 20 % (p&lt;0.018, α=0.05) and 25 % (p&lt;0.028, α=0.05)). Empirical models of the form Y=mX+C (where Y = T. diversifolia percentage and X = TKN or Nitrate-N percentage) were developed indicating significant effect of T. diversifolia on TKN and nitrate-N on resultant chimato composts. Results also showed significant improvement in TKN and nitrate-N content and C/N ratios in composts with blending ratios of Td:MS = 40:60, Td:MS = 50:50 and Td:MS = 60:40 (v/v) hence judged optimal. The observed significance is attributed to optimal initial C/N ratios, moisture and porosity of the composite ingredients that enhanced active and rapid microbial aerobic activities that limited nitrogen volatilization. Blending composition of greater than 60 % of T. diversifolia
Lipid Composition and Metabolism of Thromboatherosclerotic Lesions Produced by Continued Endothelial Damage in Normal Rabbits

Field: Medicine (Health Sciences)

Thromboatherosclerotic and fibrous lesions were produced by endothelial damage with polyethylene catheters inserted into the aortas in rabbits on a normal diet. Two weeks after insertion of the catheters, the concentration of both free cholesterol and cholesteryl ester in the thromboatherosclerotic lesions was significantly greater than that in the adjacent normal intima. A further increase in the concentration of free cholesterol and particularly of cholesteryl ester occurred during the remainder of the 4-month study period. Gas-liquid chromatography indicated that the raised thromboatherosclerotic lesions contained more cholesteryl oleate and less cholesteryl linoleate than did either the normal intima or the fibrous lesions. The incorporation of [1 -14 C] oleic acid into combined lipid in the aortas incubated in vitro showed that, by 2 weeks, two to three times more oleic acid had been incorporated into cholesteryl ester in the thromboatherosclerotic raised lesions than in the normal intima. A similar increase was demonstrated at 2 and 4 months. When [ 32 P] phosphate was used as a precursor, incorporation into lecithin was higher and incorporation into phosphatidyl inositol was lower in the raised lesions than they were in the normal intima. Fibrous lesions did not differ significantly from the adjacent normal intima in their incorporation of either of these precursors into lipid. Therefore, the accumulation of cholesteryl ester in the thromboatherosclerotic lesions resulted in part from synthesis in the arterial wall, which was stimulated by the prominent platelet components of the lesions.
The IGF2 mRNA binding protein p62 as a regulator of IGF2 and H19 expression - potential implications in tumorigenesis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Hepatocellular carcinoma (HCC) represents the fifth most common cancer worldwide. The overall survival of patients with HCC is low due to both late diagnosis and the lack of efficient systemic treatment options. Autoantigens are considered as possible diagnostic markers for several types of cancer. Aim of this work was to characterize functional implications of p62/IMP2-2, an insulin-like growth factor 2 (IGF2) mRNA binding protein and autoantigen in HCC, in liver pathogenesis. In transgenic mice expressing p62 only in the liver, levels of both Igf2 mRNA and H19, a non-coding RNA with which it shares an imprinting control region, were strongly elevated. Interestingly, although elevated p62 levels in human HCC tissues correlated with Igf2 expression, the observed antiapoptotic effect of p62 was IGF2-independent, but rather facilitated via extracellular regulated kinase (ERK) activation. p62 attenuated the expression on the tumor suppressor phosphatase and tensin homolog (PTEN), increased the levels of inflammatory cytokines, and altered hepatic fatty acid composition. Taken together, this work provides evidence for p62 being a new interesting target for both diagnostic and therapeutic options in HCC.
Microbial Contamination of Chicken Wings: An Open-Ended Laboratory Project

Field: Immunology and Microbiology (Life Sciences)

Research Article| April 01 2001 Microbial Contamination of Chicken Wings: An Open-Ended Laboratory Project Charles E. Deutch Charles E. Deutch Search for other works by this author on: This Site PubMed Google Scholar The American Biology Teacher (2001) 63 (4): 262–266. https://doi.org/10.2307/4451097 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Charles E. Deutch; Microbial Contamination of Chicken Wings: An Open-Ended Laboratory Project. The American Biology Teacher 1 April 2001; 63 (4): 262–266. doi: https://doi.org/10.2307/4451097 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentThe American Biology Teacher Search This content is only available via PDF. Copyright National Association of Biology Teachers Article PDF first page preview Close Modal You do not currently have access to this content.
Heritability of fetal hemoglobin, white cell count, and other clinical traits from a sickle cell disease family cohort

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Sickle cell disease (SCD) is the most common monogenic disorder in the world. Notably, there is extensive clinical heterogeneity in SCD that cannot be fully accounted for by known factors, and in particular, the extent to which the phenotypic diversity of SCD can be explained by genetic variation has not been reliably quantified. Here, in a family‐based cohort of 449 patients with SCD and 755 relatives, we first show that 5 known modifiers affect 11 adverse outcomes in SCD to varying degrees. We then utilize a restricted maximum likelihood procedure to estimate the heritability of 20 hematologic traits, including fetal hemoglobin (HbF) and white blood cell count (WBC), in the clinically relevant context of inheritance from healthy carriers to SCD patients. We report novel estimations of heritability for HbF at 31.6% (±5.4%) and WBC at 41.2% (±6.8%) in our cohort. Finally, we demonstrate shared genetic bases between HbF, WBC, and other hematologic traits, but surprisingly little overlap between HbF and WBC themselves. In total, our analyses show that HbF and WBC have significant heritable components among individuals with SCD and their relatives, demonstrating the value of using family‐based studies to better understand modifiers of SCD.
Calculating the local-type fNL for slow-roll inflation with a non-vacuum initial state

Field: Physics and Astronomy (Physical Sciences)

Single-field slow-roll inflation with a non-vacuum initial state has an enhanced bispectrum in the local limit. We numerically calculate the local-type fNL signal in the CMB that would be measured for such models (including the full transfer function and 2D projection). The nature of the result depends on several parameters, including the occupation number N_k, the phase angle θ_k between the Bogoliubov parameters, and the slow-roll parameter ε. In the most conservative case, where one takes θ_k \approx η_0 k (justified by physical reasons discussed within) and ε\lesssim 0.01, we find that 0 < fNL < 1.52 (ε/0.01), which is likely too small to be detected in the CMB. However, if one is willing to allow a constant value for the phase angle θ_k and N_k=O(1), fNL can be much larger and/or negative (depending on the choice of θ_k), e.g. fNL \approx 28 (ε/0.01) or -6.4 (ε/0.01); depending on ε, these scenarios could be detected by Planck or a future satellite. While we show that these results are not actually a violation of the single-field consistency relation, they do produce a value for fNL that is considerably larger than that usually predicted from single-field inflation.
Web crawler design, implementation and data analysis about Sina Weibo

Field: Computer Science (Physical Sciences)

In this paper, discussed designed and implemented a crawler base on python language and use this program crawl posts from Sina weibo. The key word is academic library. The time span is from 1/1/2018 to 31/12/2018 and the total number is 39374 and make data clean, cut words and delete all text that no related to academic library. After that, analyzed this data set for knowing the user's attitude about library. In order to describe the situation better, high frequency words rank, cloud word, semantic network about image of Library service, semantic network been used. Finally, according to the user's attitude, make the the necessary discuss.
Function and expression of checkpoint inhibitors and immune agonists on immune cells in monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM) and MM and tumor-specific T lymphocytes.

Field: Medicine (Health Sciences)

11577 Background: Characterization of expression and function of immune regulatory molecules in tumor microenvironment will provide the framework for developing novel therapeutic strategies. Methods: We evaluated the expression and functional impact of various immuno-regulatory molecules, PD-1, PDL-1, PDL-2, LAG3, TIM3, OX40 and GITR, on the CD138 + tumor cells, myeloid derived suppressor cells (MDSC), and T cell subsets from patients with MGUS, SMM and active MM (newly diagnosed, relapsed, relapsed/refractory), and the myeloma-specific cytotoxic T lymphocytes (CTL) induced with XBP1/CD138/CS1 peptides. Results: PDL-1/PDL-2 was more highly expressed on CD138 + myeloma cells in active MM than SMM or MGUS. G-type MDSC (CD11b + CD33 + HLA-DR low CD15 + ). Treg cells (CD3 + CD4 + /CD25 + FOXP3 + ) numbers were increased and expressed higher levels of PD1/PD-L1 in active MM than in MGUS, SMM or healthy donors. Among the checkpoint molecules (PD-1, PDL-1, PDL-2, LAG3, OX40, GITR) evaluated, PD-1 showed the highest expression on CD3 + CD4 + and CD3 + CD8 + T cells in BMMC and PBMC from patients with active MM. Functionally, T cells from MM patients showed increased proliferation upon treatment with an individual immune agonist ( > 150%) or checkpoint inhibitor ( > 100%). Interestingly, each individual anti-checkpoint molecule induced proliferation of T cells expressing other checkpoint molecules. In addition, the blockade of PD1, LAG3 or TIM3 enhanced MM antigen-specific cytotoxicity, assessed by parameters including CD107a, granzyme B and IFN-g production, which was most prominent within the memory CTL subset of MM antigen-specific T cells. Conclusions: These results demonstrate an increased frequency of immune regulatory cells, which highly express checkpoint inhibitors in active MM. Direct stimulation with an immune agonist or blockade of a checkpoint inhibitor increased MM patients’ T cell proliferation and myeloma-specific CTL function, supporting development of combination immune regulatory therapies to improve patient outcome in MM.