jimnoneill/paper-to-field-training huggingface dataset:
Exploring the mechanism of Si-Miao-Yong-An decoction on heart failure based on molecular docking and network pharmacology

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The SwissTargetPrediction was employed to predict the potential drug targets of the active component of Si-Miao-Yong-An decoction (SMYAD). The therapeutic targets for HF were searched in the Genecard database, and Cytoscape3.9.1 software was used to construct the "drug-component-target-disease network" diagram. In addition, the String platform was used to construct Protein-Protein Interaction (PPI) network, and the DAVID database was used for GO and KEGG analysis. AutoDockTools-1.5.6 software was used for molecular docking verification. Network pharmacology studies have shown that AKT 1, ALB, and CASP 3 are the key targets of action of SMYAD against heart failure. The active compounds are quercetin and kaempferol.
A CMOS synchronous time amplifier

Field: Engineering (Physical Sciences)

This paper presents a synchronous time amplifier (TA). The proposed TA has predictable amplification process delay and can be synchronous with a clock signal. The TA is implemented and simulated in 0.18 μm CMOS process. It works with 100 Ms/s under 1-V voltage. Simulation results show that the TA has 8ns output linear range and obtains a constant gain independent of PVT with 9.0% total gain error.
THE EUCHARISTIC DIMENSION OF CHRISTIAN ЕDUCATION ACCORDING TO SOME HOLLY FATHERS AND ОRTHODOX AUTHORS

Field: Arts and Humanities (Social Sciences)

The purpose of this paper is to present the dimension of the Eucharistic education in two directions: first, to determine that the Eucharist as the chief factor of Christian Education as viewed by some Orthodox authors; second, to revel the position of some Holy Fathers, concerning the importance of the Holy Eucharist for education. The introduction points out that the pivot of Christian upbringing is man’s incorporation into the living Body of Christ in the sacrament of the Holy communion trough faith, communion, and grace of the Holy Spirit. Christian authors emphasize the fact that the goal of Eucharistic upbringing is achieving on over all alteration of the person which means transformation of the human mind, heart and will. The most important part of this process is the alteration of the heart as viewed by the Holy Fathers quoted in this paper, namely, St. John Chrysostom, St. Gregory Palamas and St. John Damascene, St. John of Kronstadt . The inference from their writings synthesizes the chief aspects of Eucharistic education which are: reaching „deification", acquiring the Holy Spirit as well as changing one’s life trough thanksgiving, repentance for wrongdoing and love for God and the fellowmen.
A FUNDAMENTAL STUDY ON EVALUATION OF PUBLIC TRANSPORT TRANSFER POINTS BY DATA ENVELOP ANALYSIS APPROACH USING SMART CARD DATA

Field: Decision Sciences (Social Sciences)

本研究では,地方都市における公共交通再編の検討に資するためのICカードデータを用いた乗り継ぎ結節点の評価手法を提案する.具体的には,高知市中心部の公共交通機関(路面電車,バス)で利用可能なICカードから得られる利用者の乗り継ぎ履歴データを用いて,乗り継ぎ時間および乗り継ぎトリップ数などの利用実態把握を行う.更に,複数の指標を加味することが可能な包絡分析法(DEA手法)を用いた乗り継ぎ効率性の評価を時間帯と利用者の年齢を考慮して行うものである.その結果,同じ乗り継ぎ結節点においても時間帯,年代ごとに効率性が異なることがわかり,乗り継ぎに対する各乗り継ぎ結節点の特性を複数指標の効率値から把握することの必要性を把握した.
Evaluating Research Library Collections in Psychology:

Field: Arts and Humanities (Social Sciences)

By 1986, all of the University of California (U.C.) Campus Libraries as well as the Stanford University Libraries had completed the Psychology Conspectus as part of the North American Collections Inventory Project (NCIP). Phase I. Between 1986 and 1988, they participated in a "pilot" project which was designed to further review, analyze and explore possibilities for coordinating policy in the subject area of psychology. The article is a recounting of some issues and problems encountered in this attempt.
Recent insights into the role of IRF6 in craniofacial and skin development

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Genetic variation in Interferon Regulatory Factor 6 (IRF6) causes, and contributes risk for, orofacial clefting disorders. In one of these disorders, in addition to orofacial clefts, individuals have skin webbing of the lower limbs. Thus, IRF6 is a key component of palatal and skin development in humans. In mice, Irf6 is expressed in the medial edge epithelium (MEE) that is dependent on Tgfb signaling. And, Irf6 is expressed in the spinous layer of the epidermis. Moreover, mice deficient for Irf6 have abnormal skin, limb and craniofacial development, including cleft palate. In the epidermis, in vivo and in vitro analyses demonstrate that Irf6 is necessary for keratinocyte differentiation. Furthermore, keratinocytes from Irf6–/– epidermis fail to close a scratch wound and display abnormal clonal growth, suggesting abnormal cellular proliferation and migration. In the palate, growth of the shelves is not defective, but they fail to elevate above the tongue, may be due to oral adhesions. The palatal epithelium is highly adherent, but the MEE fails to undergo its normal pattern of dissolution. Mice that are compound heterozygotes for the null and hypomorphic alleles (Irf6–/neo) display less severe abnormalities than the Irf6 deficient mice. In the oral cavity, Irf6–/neo mice have less severe oral adhesions. We are assessing the Irf6–/neo mice for defects in palatal development and epithelial differentiation.
Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Background —Mice deficient in interleukin-2 (IL-2) develop inflammatory bowel disease resembling ulcerative colitis in humans. Recent studies provided evidence that αβ T cells, particularly CD4 T cells, rather than B cells, are involved in the pathogenesis of bowel inflammation of IL-2 deficient mice. Aim —To analyse the pattern of expression of cytokine mRNA in intestinal tissue of normal and IL-2 deficient mice. Methods —Expression of β-actin, IL-1α, IL-1β, IL-6, IL-10, tumour necrosis factor α (TNF-α), interferon γ (IFN-γ) and transforming growth factor β1 (TGF-β1) mRNA was analysed in colon and small intestinal tissue of both IL-2 deficient (IL-2−/−) mice and normal (wild type) litter mates (IL-2+/+) at different ages by using qualitative, as well as semiquantitative, competitive reverse transcription polymerase chain reaction (RT-PCR). Results were correlated with the phase of progression of the disease, as determined by histology. Results —IL-2−/− mice had expressed low levels of IL-1α, IL-1β, IL-6, TNF-α, and IFN-γ mRNA in the colon by 1.5 weeks of age. In advance of the development of histologically and clinically detectable bowel inflammation, expression of IL-1α, IL-1β, IL-6, TNF-α, IFN-γ, and IL-10, but not TGF-β1, mRNA increased in the colon of IL-2 deficient mice. In contrast, IL-2+/+ mice expressed TGF-β1 mRNA in colon tissue at 13 and 23 weeks of age, but not IL-1α, IL-1β, IL-6, TNF-α, IL-10, or IFN-γ mRNA. Levels of expression of cytokine mRNA in tissue from the small intestine were comparable in IL-2−/− and IL-2+/+ mice. Conclusions —Bowel inflammation in IL-2 deficient mice is preceded by an increase in IL-1α, IL-1β, TNF-α, and IFN-γ mRNA expression in colon tissue. Low levels of TGF-β1, but high levels of IL-1α, IL-1β, IL-6, TNF-α, IFN-γ, and IL-10 mRNA expression correlate with the manifestation of severe colitis, and suggest that T cells and macrophages are involved in bowel inflammation of IL-2 deficient mice.
Predicting conversion from mild cognitive impairment to Alzheimer's disease using neuropsychological tests and multivariate methods

Field: Medicine (Health Sciences)

Behavioral markers measured through neuropsychological testing in mild cognitive impairment (MCI) were analyzed and combined in multivariate ways to predict conversion to Alzheimer's disease (AD) in a longitudinal study of 43 MCI patients. The test measures taken at a baseline evaluation were first reduced to underlying components (principal component analysis, PCA), and then the component scores were used in discriminant analysis to classify MCI individuals as likely to convert or not. When empirically weighted and combined, episodic memory, speeded executive functioning, recognition memory (false and true positives), visuospatial memory processing speed, and visuospatial episodic memory were together strong predictors of conversion to AD. These multivariate combinations of the test measures achieved through the PCA were good, statistically significant predictors of MCI conversion to AD (84% accuracy, 86% sensitivity, and 83% specificity). Importantly, the posterior probabilities of group membership that accompanied the binary prediction for each participant indicated the confidence of the prediction. Most of the participants (81%) were in the highly confident probability bins (.70-1.00), where the obtained prediction accuracy was more than 90%. The strength and reliability of this multivariate prediction method were tested by cross-validation and randomized resampling.
Hashimoto’s Encephalopathy Presenting with Unusual Behavioural Disturbances in an Adolescent Girl

Field: Medicine (Health Sciences)

Hashimoto’s encephalopathy (HE) is a rare autoimmune disorder with neurological and neuropsychiatric manifestations and elevated titres of anti-thyroid antibodies. Here we are reporting a case of HE in a 19-year-old girl who presented with seizure-like episodes, confusion, and behavioural disturbances with catatonic symptoms such as posturing, echopraxia, echolalia, and ambivalence. Patient did not respond to antipsychotics and anticonvulsants. On further investigation, patient was found to have high serum anti-TPO antibodies of about 1261 U/mL with euthyroid status, which supported a suspicion of HE. Our consultant neurologist confirmed the diagnosis and she was started on injection of methylprednisolone 750 mg OD. Since patient started showing clinical improvement, her antipsychotic medications were tapered off. On follow-up, patient has recovered and is functioning well. Since HE is a diagnosis of exclusion, very high anti-TPO antibodies and good response to steroids supported the diagnosis of HE in this patient after excluding other etiological possibilities. This case has been reported because the clinical presentation was predominantly neurobehavioural manifestations which is uncommon with HE.
Common data standards for recording relevés in field survey for vegetation classification

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract. In the framework of the European Vegetation Survey common data standards are proposed for recording phytosociological relevés for syntaxonomical classification. The authors wish to establish the notion that common data standards for recording phytosociological data can only be advantageous for advancing the credibility and application of vegetation science, and may stimulate other projects.
KLF4, a Key Regulator of a Transitive Triplet, Acts on the TGF-β Signaling Pathway and Contributes to High-Altitude Adaptation of Tibetan Pigs

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract

Background: Tibetan pigs are native mammalian species on the Tibetan Plateau that have evolved distinct physiological traits that allow them to tolerate high-altitude hypoxic environments. They can be used as a suitable animal model for exploring the molecular mechanism of hypoxia adaptation in high-altitude organisms.Results: Here, based on multi-tissue transcriptional data from high-altitude Tibetan pigs and low-altitude Rongchang pigs, we performed a weighted correlation network analysis (WGCNA) and identified key modules related to these tissues. Complex network analysis and bioinformatics analysis were integrated to identify key genes and size-3 network motifs. The results showed that compared to other tissues, the lungs of Tibetan pigs and Rongchang pigs are more significantly different, showing more adaptive transcriptional changes. In the lung tissues of Tibetan pigs, we identified KLF4, BCL6B, EGR1, EPAS1, SMAD6, SMAD7, KDR, ATOH8 and CCN1 genes as potential regulators of hypoxia adaption. We found that KLF4 and EGR1 genes simultaneously regulate the BCL6B gene, forming a KLF4-EGR1-BCL6B transitive triplet. This transitive triplet, dominated by KLF4, may enhance the hypoxia adaptability of Tibetan pigs by mediating the TGF-β signaling pathway. This triplet also regulates the KDR gene, which is involved in the PI3K-Akt signaling pathway and plays an important role in hypoxia adaptation. Conclusions: We postulate that the KLF4-EGR1-BCL6B transitive triplet may contribute to the adaptation of Tibetan pigs to hypoxic environments. These findings provide new details of the regulatory architecture of hypoxia-adaptive genes and are valuable for understanding the genetic mechanism of hypoxic adaptation in mammals.
Oridonin alleviates lipopolysaccharide-induced acute lung injury in mice through inhibiting apoptosis, oxidative stress, and inflammation by modulating VIP/cAMP/PKA/AQPs signaling pathway

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Oridonin (ORI) are a traditional Chinese herbal medicine extracted from Isodon rubescens (Hemsl.) H.Ha. There are few studies on the protective effect of ORI ameliorates acute lung injury (ALI) in mice. This result showed that compared with the ALI group, ORI significantly reduced the total protein content, Wet-to-dry (W/D) ratio, the number of neutrophils, lymphocytes, and monocytes. Moreover, ORI was able to reduce cell apoptosis, the levels of Macrophage inflammatory protein-2 (MIP-2), Intercellular adhesion molecule-1 (ICAM-1), Tumor necrosis factor-α (TNF-α), Malondialdehyde (MDA) and Myeloperoxidase (MPO) and increase the level of Superoxide (SOD). In addition, ORI could up-regulate the levels of VIP, cAMP, p-PKA/PKA and AQP1. In conclusion, our findings indicate that ORI can modulate the inflammatory injury of lung tissue caused by LPS through the VIP/cAMP/PKA/AQPs signaling pathway, suggesting that ORI can be a candidate for the therapeutic or preventive intervention in acute lung inflammation.
RIBAVIRIN INDUCED ANEMIA: A CROSS SECTIONAL STUDY AMONG PATIENTS WITH HEPATITIS C, VISITING OUT PATIENT DEPARTMENT OF A MAJOR PUBLIC SECTOR TERTIARY CARE HOSPITAL, KARACHI, PAKISTAN.

Field: Medicine (Health Sciences)

Background: Hepatitis C is among one of the major global health issues; which may cause chronic liver disease, end stage liver disease, and hepatocellular carcinoma; subsequently requiring liver transplant. For HCV, standard treatment is a combination therapy of ribavirin and interferon for six months. Ribavirin fostered hemolysis is a major treatment-associated adverse effect. Our study aimed to assess ribavirin induced anemia among Hepatitis C patients visiting Civil Hospital, Karachi. Methods: A hospital-based cross-sectional study which included 106 Hepatitis C patients, of 15-60 years' age, visiting CHK, a public sector tertiary care hospital, from October 2017 to January 2018 by using non-probability convenient sampling technique. Results: Total 106 patients participated, 53 (50.0%) were males and 53 (50.0%) were females. Mean (±SD) age was 37.05 (±10.793). Mean (±SD) duration of ribavirin use was 3.03 (±1.523) months. Around 16.0% had ribavirin dose reduction. All of them experienced weakness, fatigue and light-headedness, 59.4% developed microcytic hypochromic anemia, 23.6% had severe anemia. Mean (±SD) hemoglobin level before the onset of treatment was 12.78 (±1.555). Mean hemoglobin level during treatment was 10.72g/dL. Mean reduction in hemoglobin levels was 2.07g/dL. The reduction in hemoglobin levels and the duration of therapy were correlated (p-value <0.05). The severity of anemia was related to age of the patients (p-value <0.05) but not with gender and RBC morphology. Conclusion: Ribavirin induces anemia. The duration of ribavirin therapy and initial hemoglobin levels were related to the severity of anemia, significant enough to cause dose modification and subsequently suboptimal levels affecting efficacy. In return hemoglobin reduction, dose modification and age of the patient were also related.
HAK MEREK SEBAGAI JAMINAN GADAI UNTUK PERMODALAN UMKM INDUSTRI KREATIF KERAJINAN BATIK

Field: Social Sciences (Social Sciences)

<p><em>Creative industries are industries that intensify information and creativity by relying on stock of knowledge and ideas from Human Resources (HR). One type of creative industry is the batik creative industry. Industrial development was hindered by the inability to access capital, whether provided by the government or other financial institutions. The purpose of this study was to initiate the utilization of batik industry brand rights as collateral for pawning. This type of research uses library research (library research) obtained from literature sources through library research. Then use descriptive methods. Data collection techniques in this study are document studies. Then the data analysis includes: Descriptive Analysis (Analysis Descriptive) and Content Analysis (Content Analysis). The results of the study show that brand rights can be used as collateral for pawning. The use of brand rights as collateral is expected to support the growth of the UMKM batik creative industries in Pekalongan.</em></p><p><strong><em>Keywords:</em></strong></p><p><em><em>brand rights; collateral; mortgage.</em><br /></em></p>
Teacher Characteristics and the Selection of Teachers as Consultees.

Field: Social Sciences (Social Sciences)

ABSTRACT This study focuses on the process by which school consultants select the teachers with whom they consult. Research participants were 14 certificate or doctoral matriculants in a school psychology program. A questionnaire was adminstered to all consultants consisting of ranking and rating items. Consultants were asked to: (1) list all the teachers in their consultation placement; (2) to name in rank order the two teachers they perceived as best meeting the academic and socio-emotional needs of children and the two teachers perceived as worst meeting these needs; (3) to name the two teachers most receptive to change and the two teachers least receptive to change; (4) to name the two teachers for whom they had the most personal liking and the two teachers for whom they had the least personal liking; and (5) to rate the most preferred teacher-consultee and the least preferred teacher-consultee on a nine-point scale in comparison with the other teachers in their placement school. The data indicate that the consultants most prefer to work with teachers who are classified as most able to meet socio-emotional needs of children, most receptive,to change, and most likeable. It appears that the teachers most in need of assistance are not selected for consultation. (MM)
Inactivation of the Sema5a Gene Results in Embryonic Lethality and Defective Remodeling of the Cranial Vascular System

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The semaphorins are a large family of proteins involved in the patterning of both the vascular and the nervous systems. In order to analyze the function of the membrane-bound semaphorin 5A (Sema5A), we generated mice homozygous for a null mutation in the Sema5a gene. Homozygous null mutants die between embryonic development days 11.5 (E11.5) and E12.5, indicating an essential role of Sema5A during embryonic development. Mutant embryos did not show any morphological defects that could account for the lethality of the mutation. A detailed analysis of the vascular system uncovered a role of Sema5A in the remodeling of the cranial blood vessels. In Sema5A null mutants, the complexity of the hierarchically organized branches of the cranial cardinal veins was decreased. Our results represent the first genetic analysis of the function of a class 5 semaphorin during embryonic development and identify a role of Sema5A in the regional patterning of the vasculature.
Comparison of Ai Chi and Impairment-Based Aquatic Therapy for Older Adults With Balance Problems: A Clinical Study

Field: Health Professions (Health Sciences)

Background and Purpose: Older adults with balance deficits often fear falling and limit their mobility. Poor balance is multifactorial, influenced by medication interactions, musculoskeletal and sensory system changes, and poor neuromuscular response to changes in body positions. Aquatic physical therapy (APT) is an intervention used to improve balance and decrease falls. Ai Chi is a water-based exercise program. It incorporates slow movements of progressive difficulty utilizing the upper and lower extremities and trunk coordinated with deep breathing. It is used for relaxation, strengthening, and balance training. The purpose of this study was to determine whether Ai Chi provides better results than conventional impairment-based aquatic therapy (IBAT) for older adults with balance deficits. Methods: Thirty-two community-dwelling adults, 65 to 85 years old, were referred to 2 different community pools for APT. Fifteen participants received Ai Chi-based aquatic interventions and 17 participants received an IBAT program. Physical therapists trained in both programs completed interventions and determined discharge. Physical balance measures, which included the Berg Balance Scale (BBS) and Timed Up and Go (TUG), were collected pre- and posttherapy. Self-reported outcome measures, the Activities-Specific Balance Confidence Scale (ABC) and Numerical Pain Rating Scale (NPRS), were collected pre- and posttherapy and 3- and 6-month postdischarge. Results: A 2-way (group by time) mixed-model analysis of covariance with initial outcome scores as a covariate revealed no difference between groups in any of the outcome measures (BBS, P = .53; TUG, P = .39; ABC, P = .63; NPRS, P = .27). Repeated-measures analysis and dependent t tests showed significant improvements in the BBS ( P = .00) and TUG ( P = .03) after APT. The ABC and NPRS did not improve significantly (ABC, P = .27; NPRS, P = .77). Conclusions: There were no significant differences found in balance measures, balance confidence, or pain levels for community-dwelling older adults between the Ai Chi and IBAT programs. Physical outcome measures improved with APT but patient-reported measures did not. Further study is indicated to determine the most effective treatment frequency and duration for this population.
[Lower limbs revascularization originated in the descending thoracic aorta].

Field: Medicine (Health Sciences)

The revascularization of the lower limbs through a bypass graft from the descending thoracic aorta is one of the most uncommon surgical procedures within the scope of the so-called "extra-anatomic revascularization". It is an highly selective procedure in terms of indications and is regarded as an effective hemodynamic alternative, with acceptable long-lasting results. Two patients who underwent successfully the operation are reported, followed by a discussion on the technical aspects, indications, complications and early and late results of the procedure.