jimnoneill/paper-to-field-training huggingface dataset:
Evaluation of Candidates for Lung Transplant—A Review of Patient-Specific Risk Factors

Field: Medicine (Health Sciences)

Abstract Purpose of review The purpose of this paper is to review the evaluation of patients who are potential candidates for a lung transplant. Attention is paid to patient-specific risk factors considered when determining if an individual is a candidate for a lung transplant. Recent findings Recent consensus statements and a review of the literature support the notion that patient-specific risk factors associated with adverse outcomes following lung transplant should be identified and used to determine whether an individual patient is a candidate for lung transplant. The rationale for considering these risk factors is discussed. Early referral is encouraged to enable individuals time to reduce risk when modifiable risk factors are identified. Summary Patient-specific risk factors for adverse post-lung transplant outcomes should be identified and modified, if possible, to reduce risk. Additional research is required to better understand which ones place the recipient at the greatest risk and to guide the calculation of acceptable risk. Interprofessional teams at each lung transplant center must consider the combination of patient-specific risk factors in a risk-benefit analysis to make the determination as to whether the candidate will be listed for a lung transplant. These determinations should be transparent, equitable, and communicated clearly.
Relation entre le nombre d’appels au centre de réception et de régulation des appels de Bordeaux et la densité médicale

Field: Health Professions (Health Sciences)

Introduction: the number of phone calls to the emergency medical services has been increasing for years, whereas, at the same time, the number of doctors is decreasing and areas of low medical density are emerging, commonly known as “medical deserts” in France. The objective of this study was to find a link between the number of phone calls to Gironde’s emergency medical services and medical density. Method: this is a retrospective study, describing the phone calls to emergency medical services in Gironde, compared to the medical density recovered in Open Source files. Results: between January 1, 2014 and December 31, 2018, 1,047,525 files were recorded on the Bordeaux’s emergency medical services. Multivariate analysis found a standardized coefficient of call (compared to high medical density) at 2.81 (CI95% [2.52; 3.10]) for zero medical densities, 2.30 for very low medical densities (CI95%[2.01;2.60] 1.36 for low densities (CI95%[2.01;2.60], 0.84 for average medical densities (CI95%[0.51;1.17] and -0.30 (CI95%[-0.74;0.12]) for very high densities. Discussion : several hypotheses are put forward to explain these results : patients in areas of low medical density call more for lack of a nearby medical contact person, or the patients are more well-informed, and more used to calling the regulation during office closing hours. Whereas in urban areas, with higher medical density, patients go directly to the emergency services nearby. Conclusion: the lower the medical density, the more patients call emergency medical services in Gironde.
N-Acetylneuraminic Acid Production inEscherichia coliLacking N-Acetylglucosamine Catabolic Machinery

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

N-Acetylneuraminic acid (Neu5Ac, also referred to as sialic acid) is a nine-carbon sugar found on cell surfaces in higher animals. With key roles in inflammation, brain development, viral adhesion, and production of therapeutic glycoproteins, access to Neu5Ac is essential. We demonstrate that disruption of the N-acetylglucosamine (GlcNAc) degradation pathway by deletion of nagA and bypassing the GlmMU pathway for uridine diphosphate-GlcNAc production by expression of the Saccharomyces cerevisiae genes agm1 and uap1 improves the NeuCB-based direct cell culture approach to Neu5Ac production. The Escherichia coli strain BRL04 (nanT−, nanA−, and nagA−) transformed with a polycistronic inducible expression vector encoding Agm1, Uap1, NeuB, and NeuC, cultivated in a shake-flask and fed with glycerol and GlcNAc produced Neu5Ac at 3.7 g/L (87% conversion from GlcNAc). At the 2 L bioreactor scale, production reached 7.3 g/L at a reduced conversion of 52%. These promising results suggest that this production strain is capable of generating Neu5Ac via high-density cultivation; it remains to be seen if careful control of GlcNAc feeding rate can be optimized to maximize yield.
History Education Commensurate with the School's New Tasks

Field: Arts and Humanities (Social Sciences)

Formulating the chief tasks of the forthcoming seven-year plan in the ideological realm, the XXI Congress of the CPSU emphasized in its decisions that essential was "intensification of the Party's ideological educational work, raising the communist consciousness of toilers and of the rising generation first of all, education of them in the spirit of a communist attitude toward labor, Soviet patriotism and internationalism, the overcoming of survivals of capitalism in the consciousness of peoples, the struggle against bourgeois ideology."
Nutritional Habits of Chess Grandmasters

Field: Medicine (Health Sciences)

Chess is considered a demanding activity as one single game can last even more than six hours. Grandmaster is the highest title in chess, and to the best of our knowledge, the nutritional practices of the elite chess players have not yet been studied. PURPOSE: To describe the nutritional habits of chess Grandmasters. METHODS: 72 active chess Grandmasters (18–55 years, 17 women, 55 men) from 35 countries answered an e-mailed questionnaire including fifteen items regarding nutritional topics like meal frequency, pre- and in-competition intake, and dietary supplement use, among others. RESULTS: Forty-eight players (66.7%, CI95% 54.5–77.1) ate at least three meals/day, and twenty-six players (36.1%, CI95% 25.4-48.3) usually skipped breakfast. Most of the Grandmasters (n = 48; 66.7%) reported to avoid pre-competitive overeating. During the game, sixty-nine players (95.8%, CI95% 88.3-99.1) consumed some sort of solid foods or fluids; the most frequently used solid foods were chocolate (80.5%), fruits (14.6%), cereal bars (9.8%), while water (72.1%), coffee (42.6%) and tea (29.5%) provided most of the fluid intake. In competition, half of the surveyed players (n = 36; 50%, CI95% 38.1-61.9) took fluids even without feeling thirsty. One-third of the respondents (n = 23; 31.9%, CI95% 21.7-44.1) reported dietary supplement use. A minority of chess Grandmasters (n = 2; 2.8%, CI95% 0.3-9.7) reported to have a diet supervised by nutritional specialists. Thirty-seven subjects (51.4%, CI95% 39.4–63.2) referred to practice regular physical activity as a part of their general sport training. CONCLUSIONS: The results of this study provide data on nutritional habits of active chess Grandmasters. They showed a satisfactory solid food and fluid intake during competition. However, elite chess players reported to have a defective scientific nutritional counseling.
Evaluation of GVHD And oral mucositis in patients submitted to HSCT at the STMO-CHC of UFPR

Field: Medicine (Health Sciences)

Oral graft-versus-host disease (GVHD) and oral mucositis (OM) are important complications of hematopoietic stem cell transplantation (HSCT) that significantly impact the patient's quality of life. In this context, this study aimed to evaluate the profile of patients undergoing allogeneic HSCT, assessing oral GVHD and OM occurrence. Data from medical records of patients that underwent HSCT between 2019 and 2021 were collected. Patients over 18 years old, with diseases or conditions requiring HSCT, were included. A clinical examination was performed to evaluate the occurrence of GVHD and OM. A total of 47 patients undergoing HSCT were evaluated of which 34.04% developed GVHD, and of these 81.25% have had oral involvement. As for OM, it affected 82.97% of the patients, with grades 3 and 4 being more detected. The most frequent previous disease was acute myeloid leukemia, and most of these patients received a related type of transplant (84.61%), fully compatible (53.84%), with bone marrow as a source of stem cells (53.84%). Most patients received the myeloablative conditioning regimen (69.23%). Cyclosporine was the most immunosuppressive agent used for the GVHD prevention associated with methotrexate (76.92%). Oral GVHD and OM are frequent and debilitating oral complications of HSCT, which can compromise a patient's general health and overall survival. Early diagnosis is important for a quick start of treatment and to reduce the impact on the patient's prognosis.
the Conditioning Effect of Electoral Competition

Field: Social Sciences (Social Sciences)

This paper re-examines gender differences in electoral outcomes. We consider whether electoral competition has a differential impact on the electoral fortunes of male and female quality candidates. This study uses an original data set containing detailed candidate information for U.S. House open seat primary and general elections between 1994 and 2004. The results indicate that when multiple quality candidates enter the race, female quality candidates are at a greater disadvantage when compared to their male counterparts. The results suggest that null findings from previous work are a product of the way the relationship between gender and electoral outcomes is typically modeled. Worldwide, a mere 21 percent of the members of national legislative bodies are female (IPU 2013). In some regions of the world, women have fared better in their efforts to be elected to their national governing body. For example, 42 percent of the members of national legislative bodies in Nordic countries are female, while only 13 percent of the members of national legislative bodies in Pacific countries are female (IPU 2013). Currently, the United States ranks 78th in terms of the percentage of women serving in the national legislature (IPU 2013). Indeed, only 18 percent of the members of the U.S. Congress are female (IPU 2013). Extant research identifies many factors that influence women’s election to legislative office including institutional rules such as electoral systems, gender quotas, and incumbency (Reynolds 1999; Rule 1987; Schwindt-Bayer 2005). Proportional representation electoral systems have
Prevalence of Abnormal Coronary Findings on Coronary Computed Tomography Angiography Among Young Adults Presenting With Chest Pain

Field: Medicine (Health Sciences)

Purpose: We evaluated the prevalence of coronary stenosis on coronary computed tomography angiography (CCTA) in patients aged 18 to 30 years, who presented to the emergency department with chest pain. We also examined the risk factors potentially associated with abnormal coronary findings on CCTA in this age group. Materials and Methods: A total of 884 patients were retrospectively evaluated. Indication for CCTA was guided by our hospital’s chest pain protocol based on ACC/AHA guidelines. These were performed using the standard technique and interpreted based on CAD-RADS guidelines. Scans were identified as abnormal if atherosclerotic coronary artery disease (CAD), myocardial bridging (MB), or any anatomic coronary artery anomaly were present. Results: Twenty-two percent of patients had a coronary abnormality on CCTA. The most common abnormality was MB (17.3%), followed by CAD (4.4%) and coronary anomalies (1.5%). A small minority had stenosis (2.8%), most commonly caused by CAD. Most cases with stenosis were minimal to mild (72%) with 0.8% having coronary stenosis ≥50%. Age and male sex were risk factors for both coronary artery stenosis (odds ratio: 1.32 and 4.50, 95% confidence interval: 1.03-1.69, and 1.23-16.46, P =0.028 and 0.023, respectively) and CAD (odds ratio: 1.52 and 3.67, 95% confidence interval: 1.14-2.04, and 1.26-10.66, P =0.005 and 0.017, respectively). Conclusions: Epicardial coronary stenosis is rarely the cause of chest pain among young adult patients presenting to the emergency department. Age and male sex were both risk factors for coronary artery stenosis/disease in this age group.
Tunnel current through a redox molecule coupled to classical phonon modes in the strong tunneling limit

Field: Chemistry (Physical Sciences)

The tunnel current through a redox molecule coupled to classical phonon modes is calculated in the strong tunneling limit in the Born-Oppenhiemer approximation. The effective ``potential energy'' of the phonon modes is introduced in the steady state of the in situ scanning tunneling microscope system. The expression for the tunnel current is obtained by using thermal averaging over this potential energy calculated within the spinless model in the wideband approximation. The dependence of the tunnel current on the width of the valence level of the redox molecule, the bias voltage, and the overvoltage is studied and discussed. The results of calculations of the tunnel current and the spectral density are used for interpretation of the experimental data obtained by Tao [Phys. Rev. Lett. 76, 4066 (1996)] and Visoly-Fisher et al. [Proc. Natt. Acad. Sci. U.S.A. 103, 8686 (2006)].
The Catholic Studies Reader

Field: Arts and Humanities (Social Sciences)

Abstract This is a rare book in an emerging field that has neither a documented history nor a consensus as to what should be a normative methodology. Dividing this volume into five interrelated themes central to the practice and theory of Catholic Studies —Sources and Contexts, Traditions and Methods, Pedagogy and Practice, Ethnicity, Race, and Catholic Studies, and The Catholic Imagination—the editors provide readers with the opportunity to understand the great diversity within this area of study. Readers will find essays on the Catholic intellectual tradition and Catholic social teaching, as well as reflections on the arts and literature.
Making as geographical method

Field: Social Sciences (Social Sciences)

This chapter co-opts Rumpelstiltskin as a geographer in honour of his talent for material processuality in the context of geography's current interests in material practices and emergent spatialities and subjectivities. It explores artistic practice ('making') as an explicitly geographical research method, through three analytical lenses (spatiality, materiality and subjectivity). Spatially, I argue that through making, we can map the space-times emergent from these practices and respatialize their constitutive materialities. Materially, I propose that making can open new spaces between practices to enhance our understanding of pre-reflective aspects of those practices, which can be conceptualized spatially. In terms of subjectivity, I show how making can trace the subjectivities emergent through those practices and their artistic spatialization. Cumulatively, I establish that through making, we can work with images on a more conceptual and a more implicit basis, can integrate the conceptual and the implicit, and can generate new spatialities for geographical exploration.
Phosphatase targeting in Luminal A breast cancer: PPP3CB.

Field: Medicine (Health Sciences)

Breast cancer can be positive for expression of a hormone receptor (ESR/PGR/AR) or a growth factor receptor (ERBB2). Disease recurrence following disease remission (relapse), resistance to endocrine therapy or otherwise inadequate long-term control of disease are challenges that limit effectiveness of existing drugs that treat luminal A and luminal B disease. Here we utilized whole transcriptome technologies (5, 6) to measure total transcription in the primary tumors of humans with luminal A and luminal B breast cancer. We describe one member of a group of phosphatases up-regulated and differentially expressed in human luminal A breast cancer, PPP3CB, as a catalytically available phosphatase and candidate therapeutic target for the adjunctive medical treatment of luminal A breast cancer.
Overview of ideal antilipidemic drugs: Past, present and the future

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Atherosclerosis, a disease which affects large and medium sized arteries, is now a leading cause of death in many developed countries. High serum LDL (low density lipoproteins) and VLDL (very low density lipoproteins) levels are considered as atherogenic, whereas high HDL (High Density Lipoproteins) over 60 mg/Dl has a protective effect.Literature reviews were conducted by me from different articles on hypolipidemic drugs and the present review looking forward ideal hypolipidemic drugs with their target of action in the treatment of atherosclerosis.Statins are the first line antilipidemic drugs which possess dose dependent adverse effects like muscle pain, neuropathy, hepatic dysfunction and rhabdomyolysis. Reducing the statin dose, adding drug like proproteinconvertasesubtilisin/kexin type 9 inhibitors, supplements with coenzyme Q10 and L-carnitinie are some of the approaches to reduce statin advderse effects. In future for those patients who cannot tolerate statin and for those who can’t achieve LDL target, squalene synthase inhibitors are the best choice. We focused on current existing hypolipidemic drugs, their targets and mechanism of actions and also the new ideal antilipidemic drugs of future. Ideal antilipidemic drug is one which should produce target lipid level, cause fewer side effects and drug interactions.
[[Vedere]] » Peninsula (2020) film completo streaming ita hd sqp

Field: Arts and Humanities (Social Sciences)

CLICK THIS LINK TO WATCH >> https://allocine.live/movie/581392/peninsula.html\n\n\n\nGUARDA ORA: Link diretto streaming FILM online ITA === https://allocine.live/movie/581392/peninsula.html\n\nCOMPLETO@)) Peninsula Film Italiano HD Streaming Online VK DVDrip (COMPLETO 2015)\n\n\n\nLink Streaming Peninsula === https://allocine.live/movie/581392/peninsula.html\n\nsull'uscita: 2020-07-15 (114min)\n\n\n\n\n\nTagline : Escape The Apocalypse\n\n\n\nGeneri : Action, Horror, Thriller\n\n\n\nSocietà di produzione: Next Entertainment World, RedPeter Film, Vantage Holdings\n\n\n\nPaesi di produzione : South Korea\n\n\n\nSinossi :\n\nA soldier and his team battle hordes of post-apocalyptic zombies in the wastelands of the Korean Peninsula.
An Intermittent-Combustion General Aviation Aircraft Engine Exhaust Noise prediction Algorithm

Field: Engineering (Physical Sciences)

From an environmental point of view, the reduction of aircraft noise has become an important factor recently. There are two factors that make airplane noise: propeller noise and engine noise. This report puts emphasis on only the engine noise in order to begin understanding what airplane engine exhaust noise is. At first, the engine exhaust noise is comprehended using the Dobrzynski's engine noise theory. Next, a discussion about an Embry-Riddle Aeronautical University (ERAU) engine system, engine exhaust system configurations, and microphone setting standards that show the ERAU engine system exhaust noise data. Finally, an Intermittent-Combustion (IC) General Aviation (GA) aircraft engine exhaust noise prediction algorithm using FORTRAN code is compiled. The predicted noise level by this algorithm is compared with the actual airplane engine noise data. Consequently, the results from this algorithm can serve to modify the propulsion system and to design the engine noise reduction system.
Strategy implementation: we got the people factor wrong!

Field: Business, Management and Accounting (Social Sciences)

Purpose Challenges the notion that people resist change and puts forward a strategy for getting the majority of people in an organisation to support a change initiative. Design/methodology/approach Identifies four main groups within organisations – saboteurs, groupies, double agents and mavericks – and puts forward opinions on how best to lead each group. Findings Argues that mavericks need to be supported and rewarded for their contributions, groupies must be driven and encouraged, double agents have to be persuaded and convinced and saboteurs must be handled carefully and effectively and must not be allowed to become the focal point of leadership efforts. Practical implications Reveals that, with the right management styles, most people will support or go along with organisational changes. Originality/value Contends that leaders must lead from the front when dealing with saboteurs, lead from the middle with groupies, and lead from behind with mavericks. Double agents can be convinced only through actions.
Consistency of written post‐operative patient information for common urological procedures

Field: Health Professions (Health Sciences)

Abstract Background Following urological procedures, it is common for patients to receive written handouts containing pertinent post‐operative information and advice. This study aims to assess the consistency of procedure‐specific post‐operative advice provided to patients in A ustralia. Methods Post‐operative handouts for common urological procedures were obtained from a selection of A ustralian hospitals and practising urologists' websites. Handouts were examined for consistency with regard to post‐operative advice and the F lesch– K incaid grade level was calculated to determine readability. Results In total, 209 handouts were reviewed comprising seven urological procedures. The majority of handouts provided information regarding expected symptoms (88%) and when to seek medical attention (70.8%). Overall, 85.2% of handouts provided advice about which activities should and should not be performed. Instructions for return to work (32.1%), driving (45.5%), sex (32.1%) and physical activity (56%) were less universal. Infection, bleeding, pain and swelling were the principal reasons to seek medical attention. Duration of expected symptoms and timing for resuming normal activities were the most common sources of discordance between handouts. The mean F lesch– K incaid grade level was 9.7 with a range of 6.7 to 13.6. Only 9.6% of patient information handouts had a grade level of 8 or less and no handouts were at or below the suggested grade 6 readability level. Conclusions There is a significant degree of variability in written post‐operative advice provided to patients in A ustralia. Individual surgeons and hospitals should provide specific and tailored advice directly to their own patients, written at a grade level suitable for the majority to understand.
1113 Pleural plaques: markers of asbestos exposure or indipendent risk factor for pleural mesothelioma? a case report

Field: Medicine (Health Sciences)

Pleural plaques (PPs) represent the most common non malignant asbestos-related disease. Currently PPs are widely referred as a marker of asbestos exposure and not as an independent risk factor for the development of asbestos-related neoplastic diseases (1). However, the association between PPs and pleural mesothelioma (PM) remains controversial, as some studies on cohorts of asbestos exposed workers have shown correlation between PPs and PM. Despite this, scientific literature is poor. Research has been focused on the relationship between PPs and lung cancer, while there is a lack of studies on the possible relationship between PPs and the development of PM.

Case presentation

A clinical case of a patient affected by asbestosis and PPs with a history of occupational asbestos exposure is presented. During the follow up a PM was diagnosed at a PP.

Conclusions

The widespread belief that there is no relationship between PPs and PM is not supported by a vast literature as it happens for the absence of association between PPs and lung cancer. In the patient described it is not possible to determine whether the localization of the PM at a PP is incidental or not and whether the PM can be attributed only to intense exposure or even to the presence of PPs. Similar cases may not be uncommon even if not reported in the literature.

References

. Maxim LD, Niebo R, Utell MJ. Are pleural plaques an appropriate endpoint for risk analyses?Inhalation Toxicology2015;27:321–334. . Pairon JC, Laurent F, Rinaldo M, Clin B, Andujar P, et al. Pleural plaques and the risk of pleural mesothelioma. JNCI2013;105:293–301. doi:10.1093/jnci/djs513