jimnoneill/paper-to-field-training huggingface dataset:
[Xuefu zhuyu oral liquid intervened stress-stimulated depression model rats].

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Stress can lead to behavioral changes and lowered 5-HT content of rats. The intervention of XZOL could fight against depression-induced behavioral changes and increase 5-HT content. But it did not significantly affect the brain BDNF level. We inferred that it might not effect through the BDNF pathway.
Design, Synthesis and Pharmacological Profile of LUF7746, a Novel Covalent Partial Agonist for the Adenosine A1 Receptor

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Partial agonists for G protein-coupled receptors (GPCRs) provide opportunities for novel pharmacotherapies with enhanced on-target safety compared to full agonists. For the human adenosine A1 receptor (hA1AR) this has led to the discovery of capadenoson, which has been in phase IIa clinical trials for heart failure. Accordingly, the design and profiling of novel hA1AR partial agonists has become an important research focus. In this study, we report on LUF7746, a capadenoson derivative bearing an electrophilic fluorosulfonyl moiety, as an irreversibly binding hA1AR modulator. Meanwhile, a nonreactive ligand bearing a methylsulfonyl moiety, LUF7747, was designed as a control probe in our study. In a radioligand binding assay, LUF7746’s apparent affinity increased to nanomolar range with longer pre-incubation time, suggesting an increasing level of covalent binding over time. Moreover, compared to the reference full agonist CPA, LUF7746 was a partial agonist in a hA1AR-mediated G protein activation assay and resistant to blockade with an antagonist/inverse agonist. An in silico structure-based docking study combined with site-directed mutagenesis of the hA1AR demonstrated that amino acid Y2717.36 was the primary anchor point for the covalent interaction. Additionally, a label-free whole-cell assay was set up to identify LUF7746’s irreversible activation of an A1 receptor-mediated cell morphological response. These results led us to conclude that LUF7746 is a novel covalent hA1AR partial agonist and a valuable chemical probe for further mapping the receptor activation process. It may also serve as a prototype for a therapeutic approach in which a covalent partial agonist may cause less on-target side effects, conferring enhanced safety compared to a full agonist.<br>
Garlic oil alleviates high triglyceride levels in alcohol‐exposed rats by inhibiting liver oxidative stress and regulating the intestinal barrier and intestinal flora

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Garlic oil (GO) is a kind of natural extract extracted from garlic, which has strong antioxidant activity. This study elucidates the protective mechanism of GO against alcohol‐induced high triglyceride levels. Sixty male Sprague Dawley rats were assigned to five groups, including a control group (CON), a model group (MOD) treated with alcohol 56% v/v at 8 ml kg −1 day −1 for 2 weeks then 10 ml kg −1 day −1 for 8 weeks, a low‐dose GO group (GO‐L) given GO at 20 mg kg −1 day −1 , a high‐dose GO group (GO‐H) given GO at 40 mg kg −1 day −1 , and a positive group (POS) given diammonium glycyrrhizinate at 200 mg kg −1 day −1 . The results showed that GO could significantly reduce the serum and liver triglyceride levels caused by alcohol exposure ( p < .05). The GO‐H group significantly reduced MDA level, increased SOD and GSH‐Px levels in serum, liver, and colon ( p < .05), significantly increased the levels of Sirt1 and PGC‐1α proteins and reduced FoxO1 protein level in liver ( p < .05), and significantly increased the levels of ZO‐1 and Claudin1 proteins in the colon compared to the MOD group ( p < .05). The 16S rRNA sequencing showed that the intestinal flora of the GO‐H group was significantly changed compared with the MOD group. In summary, GO has the potential to improve high triglyceride levels in serum and liver induced by alcohol exposure, which may be related to the inhibition of oxidative stress regulation of Sirt1 and its downstream proteins, and to the restoration of the intestinal barrier and intestinal flora.
The Role of Coenzymes and tRNA Modifications in Metabolic Control of Gene Expression

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The aim of this article is to discuss mechanims of metabolic control of gene expression involving modified bases and modified nucleosides in tRNA, and to show that tRNA modification serves as a mean to adapt cells to environmental changes, such as starvation or oxidation stress (Kersten, 1984; Buck & Ames, 1984). The metabolic control is triggered by specific alterations of tRNA modifications, caused by (i) changes in the levels or redox-state of coenzymes, or cofactors of the modifying enzymes (e.g. AdoMet, folate, pteridines, iron) or (ii) by the expression of an alternative tRNA gene in which the specific nucleoside to be modified is exchanged. Regulatory mechanisms that involve tRNA modifications are:
Reduction of cardiovascular disease events by worksite hypertension treatment.

Field: Medicine (Health Sciences)

A retrospective cohort study of hypertensive employees to evaluate the impact of worksite antihypertensive treatment (WST) on cardiovascular disease (CVD) over 8 1/2 years is reported. In a union-sponsored screening from August 1973 to February 1974, 604 hypertensives (greater than or equal to 160 and/or 95 mm Hg, or on medication) were identified. Of these, standardized criteria were met by 344, of whom 150 chose WST and 194 referred care (RC). The study groups were similar in age and sex composition. Union hospitalization and death records through 1982 revealed that CVD rates were fewer in WST than RC (3.0 vs 5.4/100 person-years; p less than 0.01). By contrast, nonCVD rates were similar (8.1 vs 9.6). All-cause mortality rate in WST (0.89) was significantly (p less than 0.05) lower than that in RC (1.81), as was the standard mortality ratio (55.1), based on U.S. mortality in 1978. CVD mortality was also lower (0.48 vs 1.10; NS). Persons with an initial blood pressure (BP) less than 160/95 mm Hg had CVD event rates that were low and similar in WST and RC (3.6 vs 3.5). However, among those with elevated BP at entry, WST subjects fared significantly better than RC (2.8 vs 6.1; p less than 0.001). Furthermore, in WST, previously treated patients with elevated BP at screening experienced one-third the CVD morbidity of their counterparts in RC (3.1 vs 10.8; p less than 0.01). These results extend previous evidence that WST is an effective method to achieve BP control and demonstrate that this approach to the management of hypertension alters health outcomes favorably and significantly.
Data from Local Delivery of <i>Ox40l</i>, <i>Cd80</i>, and <i>Cd86</i> mRNA Kindles Global Anticancer Immunity

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

<div>Abstract<p>Localized expression of effector molecules can initiate antitumor responses through engagement of specific receptors on target cells in the tumor microenvironment. These locally induced responses may also have a systemic effect, clearing additional tumors throughout the body. In this study, to evoke systemic antitumor responses, we utilized charge-altering releasable transporters (CART) for local intratumoral delivery of mRNA coding for costimulatory and immune-modulating factors. Intratumoral injection of the CART–mRNA complexes resulted in mRNA expression at the site of administration, transfecting a substantial proportion of tumor-infiltrating dendritic cells, macrophages, and T cells in addition to the tumor cells, resulting in a local antitumor effect. Using a two-tumor model, we further show that mRNA therapy locally administered to one tumor stimulated a systemic antitumor response, curing both tumors. The combination of <i>Ox40l</i>-, <i>Cd80</i>-, and <i>Cd86</i>-encoding mRNA resulted in the local upregulation of proinflammatory cytokines, robust local T-cell activation, and migration of immune cells to local draining lymph node or to an anatomically distant tumor. This approach delayed tumor growth, facilitated tumor regression, and cured tumors in both A20 and CT26 tumor models. These results highlight mRNA-CART therapy as a viable approach to induce systemic antitumor immunity from a single localized injection.</p>Significance:<p>The mRNA-CART system is a highly effective delivery platform for delivering immunostimulatory genes into the tumor microenvironment for potential therapeutic development.</p></div>
Cylindrical Z-pinch in gas. I. Determination of dependences between discharge integral characteristics

Field: Physics and Astronomy (Physical Sciences)

The previously unknown dependences between integral characteristics of the cylindrical Z-pinch in argon were experimentally studied at the stage of its current shell formation and at the initial stage of its plasma pinch compression. Based on these dependences, the power balance at the above stages was determined taking into account the discharge magnetic field energy, electrodynamic force work, gas ionization energy, Joule and shock heating of plasma.
The Novelties Producing by Ozonolysis of Petroleum High-Molecular Components

Field: Chemical Engineering (Physical Sciences)

Specific properties of ozonolysis products of high-molecular heteroatomic compounds (resins and asphaltenes) from crude petroleums and natural bitumens are described. It is shown that polyfunctional carboxylic acids or their salts obtaining by alkaline hydrolysis of ozonization products of heavy petroleum stocks permits to produce manifold useful novelties such as high-effective demulsifiers for petroleum dehydration process instead of expensive synthetic demulsifying reagents; water-soluble organic astringents suitable for chemical land-reclamation or to prepare moulding mixtures at the foundries; oily or emulsion lubricating coolants for metal-working tools; stimulators of soil microorganisms activity and plant growth. The new chemical products of petroleum origin are not inferior to the best synthetic reagents for the same destinations but differ from the lasts advantageously on account of the simplicity of their production technology and low cost. The optimal expenses and other principal technological parameters were established both for raw material ozonization, following alkaline treatment and final product isolation stages of the production process for each new reagent described. By means of numerous laboratory experiments and field tests performed with seeds, bulbs and grafts of different agricultural plants and with ozonolysis products produced from the resinous components of different crude petroleums it was proved that high biological activity is characteristic only of the substances obtained from high-molecular compounds from low-sulfur naphthenic crude petroleums and natural bitumens occurring, as a rule, at small burial depths. These ozonolysis products are very effective stimulants for the different plants growth, suitable for a treatment of different forms of planting materials and providing significant acceleration of early growth stages, the reduction of vegetation and ripening periods, and the increase of total productivity of agricultural plants.
A simple, ex vivo phagocytosis assay of Plasmodium vivax merozoites by flow cytometry

Field: Medicine (Health Sciences)

As phagocytosis is the first line of defense against malaria, we developed a phagocytosis assay with Plasmodium vivax (P. vivax) merozoites that can be applied to evaluate vaccine candidates. Briefly, after leukocyte removal with loosely packed cellulose powder in a syringe, P. vivax trophozoites matured to the merozoite-rich schizont stages in the presence of the E64 protease inhibitor. The Percoll gradient-enriched schizonts were chemically disrupted to release merozoites that were submitted to merozoite opsonin-dependent phagocytosis in two phagocytic lines with human and mouse antibodies against the N- and C-terminus of P. vivax Merozoite Surface Protein-1 (Nterm-PvMSP1 and MSP119). The resulting assay is simple and efficient for use as a routine phagocytic assay for the evaluation of merozoite stage vaccine candidates.
ChemInform Abstract: Oligosaccharide Analogues of Polysaccharides. Part 6. Orthogonal Protecting/Activating Groups in an Improved Binomial Synthesis of “ Acetyleno‐oligosaccharides”.

Field: Chemistry (Physical Sciences)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The blood-brain barrier glucose transporter is conserved in preterm and term newborn infants.

Field: Medicine (Health Sciences)

Glucose, an essential substrate for brain oxidative metabolism, is transported across the adult blood-brain barrier by Glut 1, a facilitative glucose transporter. Employing postmortem human brain samples and Western blot analysis, we demonstrated the presence of a 47-55 kilodalton Glut 1 protein in preterm and term newborn. The level of Glut 1 in both the preterm (24-33 weeks; n = 12) and term (38-40 weeks; n = 4) neonates was comparable to that of the adult (n = 5). Using paraffin brain sections and immunohistochemical analysis, in the preterm (24-25 weeks) and term (40 weeks) infant, similar to the adult we demonstrated the presence of Glut 1 in microvascular endothelial cells which constitute blood-brain barrier forming cells. The ontogenic conservation of the blood-brain barrier Glut 1 make detecting defective glucose transport across the neonatal blood-brain barrier feasible. Genetic or acquired defects in Glut 1 can impede the transport of glucose across the blood-brain barrier, thereby, resulting in irreversible neurological compromise during infancy. Earlier detection during the neonatal period, and appropriate intervention, may set the stage for altering the outcome of affected infants.
The Control of Menopausal Symptoms with Estradiol Benzoate

Field: Medicine (Health Sciences)

Journal Article The Control of Menopausal Symptoms with Estradiol Benzoate Get access E. G. WATERS, M.D., F.A.C.S. E. G. WATERS, M.D., F.A.C.S. 1Jersey City, New Jersey Search for other works by this author on: Oxford Academic Google Scholar The Journal of Clinical Endocrinology & Metabolism, Volume 1, Issue 11, 1 November 1941, Pages 895–898, https://doi.org/10.1210/jcem-1-11-895 Published: 01 November 1941 Article history Received: 09 June 1941 Published: 01 November 1941
The Medieval Antecedents of English Agricultural Progress

Field: Arts and Humanities (Social Sciences)

Journal Article The Medieval Antecedents of English Agricultural Progress Get access The Medieval Antecedents of English Agricultural Progress, by Bruce M.S. Campbell (Aldershot: Ashgate, 2007; pp. xiv + 348. £65). Mark Page Mark Page Victoria County History, Oxfordshire Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume CXXIII, Issue 503, August 2008, Pages 1012–1013, https://doi.org/10.1093/ehr/cen199 Published: 01 August 2008
Benchmarking Using Critical Success Factors to Implement Macrologistics Strategies

Field: Business, Management and Accounting (Social Sciences)

The concept of Critical Success Factors was first popularized by Jack Rockart of Massachusetts Institute of Technology. The benchmarking consulting firm of Michael M. Kaiser provides this observation: "The most common reason why firms have not performed a more Competitive analysis is the perceived difficulty of finding the required data. The MIT team, headed by Jack Rockart, identified four prime sources of logistics-based critical success factors: Items one to three covered above suggest a strong alignment as well as integration role for Benchmarking in the competitive intelligence and strategic planning process. Daniel focused on those critical success factors that are relevant for any company in a particular industry, and he used the supermarket logistics model as an illustration. Benchmarking can be defined as the systematic comparison of elements of the performance of an organization against that of other organizations, usually with the aim of mutual improvement.
Miltirone Induces G2/M Cell Cycle Arrest and Apoptosis in CCRF-CEM Acute Lymphoblastic Leukemia Cells

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Miltirone (1) is a diterpene quinone extracted from a well-known Chinese traditional herb (Salvia miltiorrhiza). We investigated the cytotoxic effects of miltirone toward sensitive and multidrug-resistant acute lymphoblastic leukemia cell lines. Miltirone inhibited multidrug-resistant P-glycoprotein (P-gp)-overexpressing CEM/ADR5000 cells better than drug-sensitive CCRF-CEM wild-type cells, a phenomenon termed collateral sensitivity. Flow cytometric analyses revealed that miltirone induced G2/M arrest and apoptosis. Furthermore, miltirone stimulated reactive oxygen species (ROS) generation and mitochondrial membrane potential (MMP) disruption, which in turn induced DNA damage and activation of caspases and poly ADP-ribose polymerase (PARP). Downregulation of CCNB1 (cyclin B1) and CDC2 mRNA and upregulation of CDKN1A (p21) mRNA were in accord with miltirone-induced G2/M arrest. Moreover, miltirone decreased cell adherence to fibronectin. Molecular docking revealed that miltirone bound to the ATP-binding site of IKK-β. In conclusion, miltirone was collateral sensitive in multidrug-resistant P-gp-overexpressing cells, induced G2/M arrest, and triggered apoptosis via ROS-generated breakdown of MMP and DNA damage. Therefore, miltirone may be a promising candidate for cancer chemotherapy.
Identity, place and health reform : a case study of nurses' professional identity in a New Zealand town.

Field: Health Professions (Health Sciences)

This research is a critical study of small town nurses in light of the recently introduced market model in health management and services. I examine the professional identity of Registered Nurses by looking at how this . newly defined 'market worker' negotiates a place within the discourses of restructuring and the quasi-rural town. Among the new challenges for nurses faced by restructuring are the issues of flexibility and mobility. Reform in the health sector in New Zealand has resulted in the scaling down, and in some cases closure,. of hospital facilities in towns. Some types of nursing work in towns are no longer practiced resulting in de-skilling, particularly in the area of surgical nursing. The remaining jobs, however, encompass multiple skills, and thus require functionally flexible or multiskilled staff. It is argued that global processes, such as a shift to a market economy and restructuring are affected by place and hence differentially experienced by people in different locales. Small towns, for example, can be seen as a site of marginality in national and global terms and this in hrrn shapes the employment structure for nurses. Thus town nurses are more likely to be marginalised in a hierarchy which privileges highly specialised and high technology city nursing as opposed to low technology and functionally flexible or multiskilled town nursing. In this research paper I argue that factors such as de-skilling, a shift to multiskilling and a recent loss of pay and work conditions in a small New Zealand town contribute to a crisis in professional identity among nurses. This crisis gives rise to several responses, for example, the proposal to either shift or commute for alternative nursing work (mobility), or to leave nursing altogether. 'Choices' Stffrounding paid work, even when a professional identity seems to be under threat, are seen to be highly contingent and the negotiation process of enabling and constraining discourses often eventuates in adjustment to the status quo.
P791: Effectiveness of expanded carrier screening and prenatal ultrasound in identifying disorders among consanguineous couples

Field: Medicine (Health Sciences)

Guidelines from the American College of Medical Genetics and Genomics (2021) recommend that consanguineous couples be offered Tier 4 expanded carrier screening (including genes with <1/200 carrier frequency) (Gregg 2021). Regarding autosomal recessive disease risk, it remains unclear how Tier 4 testing will perform. In the setting of a prior fetus or child with anomalies, the yield for diagnosis with exome or genome may be the highest but might not always be available. Our study aimed to determine the potential effectiveness of expanded carrier screening (ECS) and prenatal ultrasound (US) for identification of disorders among consanguineous couples.
Station list and links to master tracks in different resolutions of POLARSTERN cruise PS82 (ANT-XXIX/9), Cape Town - Cape Town, 2013-12-19 - 2014-03-05

Field: Earth and Planetary Sciences (Physical Sciences)

Station list and links to master tracks in different resolutions of POLARSTERN cruise PS82 (ANT-XXIX/9), Cape Town - Cape Town, 2013-12-19 - 2014-03-05
Poly cystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case-control study Emily J. FearnleyLouise MarquartAmanda B. Spurdle • Philip WeinsteinPenelope M. WebbThe Australian Ovarian Cancer Study Group and The Australian National Endometrial Cancer Study Group

Field: Medicine (Health Sciences)

Objective Although polycystic ovary syndrome (PCOS) is commonly cited as a risk factor for endometrial cancer, supporting epidemiological evidence is currently very limited. Our aim was to assess the associations between PCOS, PCOS symptoms, and risk of endometrial cancer in women aged less than 50 years. Methods Data came from a national population-based case-control study in Australia. Cases with newly diagnosed histologically confirmed endometrial cancer were identified through treatment clinics and cancer registries Australia wide. Controls were randomly selected from the national electoral roll. Women were interviewed about their reproductive and medical history, including selfreported PCOS, and lifestyle. Current analyses were restricted to women aged under 50 (156 cases, 398 controls). We estimated odds ratios (OR) using logistic
Natural killer cells—toward clinical application

Field: Immunology and Microbiology (Life Sciences)

Abstract Natural killer (NK) cells are non‐B, non‐T lymphoid cells of uncertain lineage that rapidly recognize and lyse a large variety of tumor or virus‐infected cells, without the need for either prior sensitization or major histocompatability complex (MHC)‐dependent recognition. Though some essential problems in understanding NK cell function are still unsolved, considerable progress has been achieved in recent years following the identification of the characteristic large granular lymphocyte (LGL) morphology of NK cells and their purification, the study of their function at the single‐cell level, and the cloning of mouse and human NK cell lines. Activated mainly by interferon (IFN), as well as important producers of IFN, NK cells appear to have a distinct role in immunoregulation in addition to their postulated major role in “immune surveillance,” for which convincing in vivo data has accumulated. Future clinical applications may therefore include manipulations of the NK system through expansion and activation of patient's LGL or the use of cloned human NK cell lines.