jimnoneill/paper-to-field-training huggingface dataset:
Neonatal Asphyxia

Field: Medicine (Health Sciences)

Abstract

objectives

to assess the prevalence of COVID-19 (PCR-test) in residents and staff of a nursing home. To examine the presence of IgM and IgG antibodies in the sample and the relation between PCR and antibody test results.

design

cross-sectional and (retrospective) cohort study

setting

a nursing home for the elderly Bessemerberg in Lanaken (Belgium) with up to 130 beds. Lanaken is situated in the Belgian province with the highest COVID-19 prevalence.

participants

residents (N=108) and staff members (N=93) of the nursing home

outcomes

PCR, IgM and IgG

results

the prevalence of COVID-19, based on PCR test was 34% (N=40) for residents and 13% (N=11) for staff members, respectively. Of the residents, 13% showed positive IgM results and 15% positive IgG results. In 17% of the residents, at least one of the antibodies was positive. In total 13% of the staff members had positive IgM and 16% had a positive IgG. In 20% of the staff members at least one of these antibody tests was positive. In PCR positive residents, the percentage of IgM positive, IgG positive, and at least one of both was 28%, 34%, and 41%. In PCR positive staff, we found 30%, 60%, and 60%. Additional antibody tests were performed in nine residents between day 11 and 14 after the positive PCR test. Of those, 7 (78%) tested positive on at least one antibody. When retesting three weeks later, all remaining residents also tested positive.

conclusions

Recently it was reported that in Belgium antibodies are present in 3-4% of the general population. Although, the prevalence in our residents is higher, the number is largely insufficient for herd immunity. In staff members of the regional hospital the prevalence of antibodies was 6%. The higher prevalence in nursing home staff (21%) may be related to the complete absence of good quality protection in the first weeks of the outbreak.

Article summary

Strengths and limitations of this study

- This is the first study in Belgium examining the prevalence of COVID-19 and the presence of antibodies in residents and staff members of a nursing home - The internal procedural control was positive -with one exception- in all tests, which suggests good quality sampling and testing. - Some degree of selection bias should be assumed in residents, since some residents were absent; mostly from hospitalisation or death which can be related to the presence of COVID-related disease. - The study was set up in one nursing home and is consequently not representative for the whole of the Flemish community
A Dose Response for Radiation-Induced Intrachromosomal DNA Rearrangements Detected by Inverse Polymerase Chain Reaction

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

X-ray-induced intrachromosomal DNA rearrangements were detected in the 5' region of the MYC gene of cells of the human bladder carcinoma cell line, EJ-30, by using PCR with inverted primers. When the cells were allowed to repair/misrepair for 6 or 23 h after irradiation, the frequency of rearrangements increased with dose from (0.7 +/- 0.4) x 10(-5) per copy of MYC for unirradiated cells to (3.2 +/- 0.7) x 10(-5) after 30 Gy, (5.4 +/- 1.2) x 10(-5) after 70 Gy, and (5.9 +/- 1.0) x 10(-5) after 100 Gy. No significant difference was observed between 6 and 23 h of repair. Sequences obtained from the products suggest that there was no homology between the two sequences involved in the recombination event and that there was no clustering of breakpoints. The procedure is relatively simple, requiring only one digestion with a rare-cutting restriction enzyme prior to PCR amplification of the DNA purified from irradiated cells. The site of enzyme digestion is located between a pair of primer sites 120 bp apart for which the primers face in opposite directions. If no intrachromosomal rearrangement has occurred, no PCR product would be obtained. However, if an intrachromosomal rearrangement has occurred between two regions located on either side of the primer sites, an episome or duplication event would result if the rearrangement had occurred either within the same chromatid or between two sister chromatids, respectively. Digestion between the primers would linearize an episome or release a linear molecule containing the duplicated primer sites from a larger molecule. After both types of rearrangement events, the primers would be facing each other and would be located on either end of the linear molecule; and if they are less than approximately 5 kb apart, PCR amplification should result in a product. This procedure is relatively simple and rapid and does not require any cell division after irradiation or phenotypic selection of mutants. Also, quantification is based on the number of PCR products detected in a known amount of DNA, and not on a precise determination of the amount of PCR amplification that has occurred. Thus the inverse PCR procedure has the potential ofbeing used as an assay to detect variations in radiation-induced frequencies of DNA rearrangements.
1489: Validation of the Kattan Nomogram for Predicting Cancer on Repeat Prostate Biopsy after an Initial Biopsy that was Negative for Cancer

Field: Medicine (Health Sciences)

You have accessJournal of UrologyDiscussed Poster, Wednesday, May 25, 2005, 8:00am - 12:00 pm1 Apr 20051489: Validation of the Kattan Nomogram for Predicting Cancer on Repeat Prostate Biopsy after an Initial Biopsy that was Negative for Cancer Joel W. Slaton, Steven Schwartz, Neil Wasserman, and Badar M. Mian Joel W. SlatonJoel W. Slaton More articles by this author , Steven SchwartzSteven Schwartz More articles by this author , Neil WassermanNeil Wasserman More articles by this author , and Badar M. MianBadar M. Mian More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)35623-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1489: Validation of the Kattan Nomogram for Predicting Cancer on Repeat Prostate Biopsy after an Initial Biopsy that was Negative for Cancer." The Journal of Urology, 173(4S), p. 403 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 403 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Joel W. Slaton More articles by this author Steven Schwartz More articles by this author Neil Wasserman More articles by this author Badar M. Mian More articles by this author Expand All Advertisement PDF downloadLoading ...
Mergers and Competition: The Brewing Case

Field: Economics, Econometrics and Finance (Social Sciences)

In 1960, the first major decision of any doctrinal importance concerning mergers under section 32 of the Combines Investigation Act was handed down in the Supreme Court of Ontario. This decision established that there is no merger problem under the Act unless the fusion of firms creates a monopoly situation. Such a test, aside from being incomprehensible in economic terms, is based on a narrow legal premise (that may or may not be legally correct) which, taken together with the decision in R. v. British Columbia Sugar Refining Co. Ltd. and the inexplicable decision of the Crown to appeal neither case, has resulted in complete emasculation of the merger section of the Act. In effect, mergers have ceased to become an economic problem. The purpose of this paper is to reevaluate the Brewing case solely in terms of economic criteria, by putting economic flesh on the bones of the statutory offence: “merger … which has operated or is likely to operate to the detriment or against the interest of the public.” Such criteria as will be erected are generally applicable to the section because here the application of appropriate economic criteria requires not so much a change in the Act as a better and more sophisticated treatment in the courts.
A case report of intraoperative management for hyperfibrinolysis in the patient with intracranial meningioma.

Field: Medicine (Health Sciences)

髄膜腫症例の中に腫瘍由来のPlasminogen activator産生が亢進しているものが報告されている.術前検査でFDP値は正常であったが,その他の検査で線溶活性の亢進がみられたことからPlas-minogen activator産生が疑われた症例の腫瘍摘出術の麻酔を経験した.術中は腫瘍摘出操作開始とともにFDP値が次第に上昇し易出血性を認めるようになった.髄膜腫摘出術において予測以上の出血が認められる場合には手術操作開始によって放出反応が亢進するPlasminogen activator産生性髄膜腫を疑い,FDP値などを線溶系の指標として抗プラスミン剤の投与を考慮することが必要と思われた.
A Feasibility Study of a Volunteer Navigation Program in the Palliative Context

Field: Health Professions (Health Sciences)

Older persons with serious illnesses living in rural communities are an underserved population. They often live with heavy symptom burden and poor quality of life with limited access to resources. Nav-CARE (Navigation: Connecting Accessing Resourcing and Engaging) was developed to specially train and mentor volunteer navigators who help connect older persons with serious illness to the resources and information they need. Aims: This mixed methods longitudinal study evaluated Nav-CARE for feasibility, acceptability, ease of use, and satisfaction by older persons and volunteers. Methods: Nine volunteer navigators visited 23 older persons with serious illness every 3 to 4 weeks for 1 year. Data were collected from volunteer navigators, and older person participants at baseline, during the year- long implementation and post implementation. Results: Volunteer navigators and older persons reported Nav-CARE was easy to use, feasible and acceptable. The majority of older persons agreed or strongly agreed that they were satisfied with the navigation services (100%; 8/8), that navigation services were important to them (87%; 7/8), that they would recommend the program to someone else (87%; 7/8), and would participate in the program again (75%; 6/8). Similarly, volunteer navigators reported 100% (9/9) satisfaction with the program, 100% (9/9) would recommend it to others, and 67% (6/8) would participate again. Conclusions: Nav-CARE appears to be a feasible, acceptable, and satisfactory program for older persons with serious illness and volunteer navigators.
Seismic Behavior of Steel-Concrete Composite Columns Under Cyclic Lateral Loading

Field: Engineering (Physical Sciences)

<p>Lightweight concrete has been used in the construction industry for many years and by the introduction of modern technologies in the construction industry, this type of concrete has been accounted as one of the powerful and reliable materials in the construction industry. The density of lightweight concrete is about 0.56 that of the ordinary concrete. This type of concrete is commonly used as a flooring material in buildings. Thus there is possibility of its corrosion in different climatic conditions. In the present research, we would investigate the compressive strength and durability of the lightweight concrete in the acid environment, so that by specifying the corrosion rate, one could have a better understanding of the behavior of these concretes. For making the lightweight concrete in the present research use has been made of pumice aggregate in the mix design, and the acid used is 1M sulfuric acid. Also, the effect of adding two types of Nanomaterials i.e., Nano silica and Nano clay on the concrete behavior is assessed. The results have shown that in case of keeping the specimens of lightweight concrete in the acid environment for 90 days, their weight reaches 0.56 that of the ordinary specimens. The results of the current research have shown that the use of Nano silica and Nano lime per 10 wt% of cement could result in the increased compressive strength of the lightweight concrete. So that the concrete compressive strength per 10 wt% of Nano lime increases by 1.43%. On the other hand, the concrete durability in the acid solutions reaches the maximum value per addition of 5% Nano silica and 5% Nano lime, and has lost a lower percentage of its weight.</p>
ROLE OF INHIBITION AND SPIKING VARIABILITY IN ORTHO- AND RETRONASAL OLFACTORY PROCESSING

Field: Neuroscience (Life Sciences)

Odor perception is the impetus for important animal behaviors, most pertinently for feeding, but also for mating and communication. There are two predominate modes of odor processing: odors pass through the front of nose (ortho) while inhaling and sniffing, or through the rear (retro) during exhalation and while eating and drinking. Despite the importance of olfaction for an animal’s well-being and specifically that ortho and retro naturally occur, it is unknown whether the modality (ortho versus retro) is transmitted to cortical brain regions, which could significantly instruct how odors are processed. Prior imaging studies show different brain activity for the two modes, even with identical odors. However, odors are first processed via coordinated spiking of neurons in the olfactory bulb (OB) before being relayed downstream to higher cortical regions. Thus, we investigate responses of mitral cells (MC), one of principle neurons in OB, to ortho and retro stimulus to elucidate how the OB processes and codes this information. We analyze our collected in vivo rat data to inform modeling of the OB circuitry and MC responses to both modes of olfaction. Our efforts show that the OB does indeed process odors differently and that the temporal profile of each stimulus route to the OB is crucial for distinguishing ortho and retro odors. Additionally, we detail the rich spiking dynamics observed in our MC model and use a phenomenological model to explain the unexpected non-monotonic spike variability observed as weak-to-moderate background noise increases. Lastly in both anesthetized and awake rodents, we show that MCs with synaptic connections to cortical regions reliably transmit ortho versus retro input stimulus information. Drug manipulation affecting GABAA-mediated synaptic inhibition leads to changes in decoding of ortho/retro and only affects firing response for one of the two modes. We have not only shown that ortho versus retro information is encoded to downstream brain regions, but with models and analysis, we uncover the network dynamics that promote this encoding.
Hyperammonemic encephalopathy in a patient receiving fluorouracil/oxaliplatin chemotherapy

Field: Medicine (Health Sciences)

Key Clinical Message Hyperammonemia is a rare adverse effect of 5‐fluorouracil (5‐ FU ) therapy, but can be very serious, even fatal. Physicians must be aware that hyperammonemic encephalopathy sometimes develops as an adverse event after 5‐ FU therapy.
Memory Clinics

Field: Health Professions (Health Sciences)

Memory clinics provide a specialist outpatient-based service offering comprehensive assessment, diagnosis, treatment and advice for people with memory disorders and their families. They also act as a focus for education and research. Much of their activity centres on the diagnosis and management of dementia, typically with emphasis on encouraging earlier presentation, differential diagnosis, appropriate use of drug treatments and psychosocial interventions. Characteristically the clinics are multidisciplinary in nature, with specialist medical input (geriatrician, psychiatrist and/or neurologist), psychologist, nurse and sometimes speech and language therapist, occupational therapist and social worker. The limited published evidence of effectiveness suggests improved quality of life of patients, reduced carer burden, less hospitalization and possible postponement of need for institutional care.
Lymphoepithelioma-like carcinoma of the parotid gland in a patient with rheumatoid arthritis.

Field: Medicine (Health Sciences)

Lymphoepithelioma-like carcinoma (LELC) is an Epstein-Barr virus (EBV) related malignancy. It is not a common condition and is usually found in the head and neck region. We describe the development of LELC involving the parotid gland in a patient with rheumatoid arthritis (RA) who had been receiving long-term azathioprine. A brief review is also made on the clinical presentation and histological features of LELC and the association of RA with EBV related diseases. The latter may be attributed to an increase in risk of malignancy associated with RA or as a result of the long-term immunosuppressive used.
Dynamic Programming Through the Lens of Semismooth Newton-Type Methods (Extended Version)

Field: Mathematics (Physical Sciences)

Policy iteration and value iteration are at the core of many (approximate) dynamic programming methods. For Markov Decision Processes with finite state and action spaces, we show that they are instances of semismooth Newton-type methods to solve the Bellman equation. In particular, we prove that policy iteration is equivalent to the exact semismooth Newton method and enjoys local quadratic convergence rate. This finding is corroborated by extensive numerical evidence in the fields of control and operations research, which confirms that policy iteration generally requires few iterations to achieve convergence even when the number of policies is vast. We then show that value iteration is an instance of the fixed-point iteration method. In this spirit, we develop a novel locally accelerated version of value iteration with global convergence guarantees and negligible extra computational costs.
LHD 4O-BC02-R01 #191960.1 (analyzed)

Field: Physics and Astronomy (Physical Sciences)

Luminance data of the plasma monitor camera. Time variation of the average and maximum luminance within the ROI (Region of Interests) of the plasma images observed by the 4-O port camera, where ROI is (920,230) - (982,304) of the original image of 1920x1080. The luminance value is between 0 and 255 in arbitrary unit.
Supply chain flexibility

Field: Business, Management and Accounting (Social Sciences)

Purpose The conceptualization of flexibility in organizations historically emerged from three views which relate to economic, to organizational and to manufacturing perspectives. Despite the growing number of publications about supply chain flexibility in the area of supply chain management, there is a lack of consensus on how to define and to conceptualize supply chain flexibility from a management point of view. The purpose of this paper is to present a comprehensive overview of the literature on the supply chain flexibility perspective and contributes to our understanding of the current state of research and its future development. Design/methodology/approach The research methodology used is the systematic literature review. In total 92 articles were selected from databases of well-known journal publishers in the field of economics, business studies and management sciences as well as grey literature to cover the topic of supply chain flexibility. Findings A limited number of studies in the field of supply chain flexibility apply theories and define the term supply chain flexibility. Instead they focus on a particular part or dimension of the supply chain. Based on the analysis, a distinction is made between flexibility in the supply chain and supply chain flexibility. Based on the function and characteristics of the supply chain, the authors selected 30 flexibility dimensions that cover supply chain flexibility by concentrating on the different business areas involved. Research limitations/implications The results support researchers and practitioners by identifying relevant trends and gaps in the field of supply chain flexibility. Originality/value The authors review the dimensions and aspects of supply chain flexibility that are currently taken into account in the literature. In this way, the authors provide an overarching perspective on the flexibility literature relating to supply chains.
A model for predicting stress levels and marital satisfaction for stepmothers utilizing a stress and coping approach

Field: Psychology (Social Sciences)

Drawing from a stress and coping framework and previous research regarding stepfamilies, the researchers develop and test a theoretical model predicting stepmother stress and marital satisfaction. Factors in the model include residency of the stepmother's stepchildren, whether the stepmother has biological children, social support resources, role clarity, and responsibility for household chores and stepchild care. The results indicate that the data fit the model well. By examining all of these variables in a model several advantages are achieved, including integrating and extending prior research findings on stepfamilies, comparing the relative strengths of these variables in their relationship with stress and satisfaction, and illustrating factors that can be targeted to encourage the viability of the various types of stepmother—father couples.
~*PDF $^EPub!$PDF ~*EPub 13 Reasons Why Full PDF

Field: Arts and Humanities (Social Sciences)

Read Or Download 13 Reasons Why Full Books By by Jay Asher (Author)\n\nRead Online => Read 13 Reasons Why\n\nDownload Book => Download 13 Reasons Why\n\n13 Reasons Why pdf download\n13 Reasons Why read online\n13 Reasons Why epub\n13 Reasons Why vk\n13 Reasons Why pdf\n13 Reasons Why amazon\n13 Reasons Why free download pdf\n13 Reasons Why pdf free\n13 Reasons Why pdf\n13 Reasons Why epub download\n13 Reasons Why online\n13 Reasons Why epub download\n13 Reasons Why epub vk\n13 Reasons Why mobi\n\n\n#downloadbook #book #readonline #readbookonline #ebookcollection #ebookdownload #pdf #ebook #epub #kindle
IL-17 Inhibition vs IL-23 Inhibition for Psoriatic Arthritis: An Ongoing Debate

Field: Medicine (Health Sciences)

The interleukin-17 (IL-17) and interleukin-23 (IL-23) pathways play a central role in the pathogenesis of psoriatic disease (PsD). This review outlines the immunobiology of these cytokine pathways and summarizes the current evidence on the efficacy and safety of IL-17 and IL-23 inhibitors across PsD domains, including peripheral arthritis, axial arthritis, enthesitis, dactylitis, psoriasis, and inflammatory bowel disease (IBD). IL-17 inhibitors, which target the effector cytokines IL-17A, IL-17F, or their receptors, have demonstrated robust efficacy in psoriasis, peripheral arthritis, and axial disease. IL-23 inhibitors act upstream by targeting the p19 subunit of IL-23 and show comparable efficacy in peripheral arthritis and psoriasis, though evidence for efficacy in axial disease remains limited. While IL-17 inhibitors carry a risk of IBD exacerbation, IL-23 inhibitors are considered therapeutic options for patients with coexisting IBD. In addition, radiographic progression appears better suppressed by IL-17 inhibitors, although emerging data suggest that IL-23 blockade may offer delayed benefits. Both IL-17 and IL-23 drug classes exhibit favourable safety profiles, with clinical trials suggesting slightly better tolerability for IL-23 inhibitors. Future directions include head-to-head comparisons, biomarker-guided treatment selection, and trials assessing long-term structural outcomes. Understanding the tissue- and cell-specific effects of inhibiting these cytokine pathways is key to optimizing therapy in PsD.
The dietary therapy and use of probiotics in the treatment of pediatric acute diarrhea

Field: Medicine (Health Sciences)

In the process of medical care of acute diarrhea in children, two pathophysiologic aspects should be considered: dehydration associated with electrolyte imbalance, and nutritional disorder. It is important to continue to provide foods easy to digest with appropriate recipes from the early stage after a remedy of dehydration using oral rehydration solution or intravenous fluid therapy according to patients’ condition. Nil per os or diluted diet can slow the recovery of an intestinal function and lengthen the diarrheal period. Although the damage on the intestinal mucosa occurs from various causes, the gastrointestinal mucosa maximizes absorbing capacity by expanding the area of a surface. Early oral-feeding contributes to restoring mucosa favorably and thus facilitates a rapid improvement of symptoms. Breast-feeding should continue to be performed in the midst of rehydration, and lactose-containing regular cow’s milk formula is recommended for cow’s milk-fed patients after rehydration. In mild or severe acute diarrhea, administering probiotics in conjunction with feeding is expected to shorten the diarrheal period.