jimnoneill/paper-to-field-training huggingface dataset:
Abstract TP92: When Less is More: Do We Need Advanced Perfusion Neuroimaging Prior to Mechanical Thrombectomy?

Field: Medicine (Health Sciences)

Objective: To assess whether the choice of pretreatment neuroimaging has an impact on clinical outcomes following mechanical thrombectomy (MT). Background: Most MT trials required advanced neuroimaging including either CT or MR based perfusion studies for patient selection prior to randomization. However, in practice, centers may offer MT based on favorable findings (ASPECT score > 6) on non-contrast head CT (HCT) ± CT angiogram (CTA). We compared outcomes between patients who underwent MT based on HCT ± CTA (HCT- group) versus additional including CT or MR perfusion scan (HCT+ group). Design/Methods: Case records of all patients who underwent MT at our center between Jun 2012 - Jun 2017 were reviewed. Patient demographics, risk factors, presentation, pretreatment scan findings, treatment times and clinical outcomes were compared. Favorable outcome is defined as mRS of 2 or less at 90-days. Results: A total of 528 patients were identified, of which 46.4% were male. There were 385 (72.9%) patients who underwent MT based on findings on HCT or CTA (HCT-); while the remaining 143 (27.1%) also underwent additional CTP (121/528; 22.9%) or MRI perfusion (22/528; 4.2%) prior to MT (HCT+). Median age (73 vs 72, p=0.1) and baseline ASPECT scores (8.4 vs. 8.3, p=0.5) were comparable. The HCT- patients had higher NIHSS (17.8 vs. 15.3, p<0.01) and presented earlier with faster onset-to-onsite arrival time (241 vs. 476 minutes, p<0.01). Also, rate of TICI 2b/3 recanalization was higher in the HCT- group (82.8 vs 71.5, p<0.01); however favorable outcome rates were comparable (44.6 vs 47.4, p=0.6). Conclusions: Our findings suggest that HCT ± CTA based MT selection may achieve similar outcomes as compared to more advanced perfusion based neuroimaging protocols. Further prospective studies are warranted.
Improving the Coherence of Multi-document Summaries: A Corpus Study for Modeling the Syntactic Realization of Entities

Field: Computer Science (Physical Sciences)

References included in multi-document summaries are often problematic. In this paper, we present a corpus study performed to derive statistical models for the syntactic realization of referential expressions. Our work shows how the syntactic realization of entities can influence the coherence of the text and provides a model for rewriting references in multi-document summaries to smooth disfluencies. It shows how the syntactic realization of entities can influence the coherence of the text and how rewrite change s can smooth the disfluencies. A large corpus study is conducted in order to derive initial models for syntactic realization.
Music pedagogical conference on research and practice in music education

Field: Arts and Humanities (Social Sciences)

This report is about a music education conference with international participation in September 2024 and was hosted by the Department of Music Education at the Faculty of Education, Charles University in Celetná Street, Prague. During the three days, scientific papers were presented, and two symposia and practical papers were presented. The conference included numerous inspiring workshops, a meeting of music education didacticians, a memorial meeting about Pavel Jurkovič, and a very successful and musically well prepared accompanying programme in three evening concerts. The conference was held on the occasion of the 90th Anniversary of the Society for Music Education of the Czech Republic.
Fiscal Requirements for Price Stability

Field: Economics, Econometrics and Finance (Social Sciences)

Maintaining price stability requires not only commitment to an appropriate monetary policy rule, but an appropriate fiscal policy rule as well. Ricardian equivalence does not imply that fiscal policy is irrelevant, except in the case of a certain class of policies (&quot;Ricardian&quot; policies). The role of fiscal developments in inflation determination under a non-Ricardian regime is illustrated through an analysis of the bond-price support regime of the 1940s. A monetary-fiscal regime with attractive properties would combine a &quot;Taylor rule&quot; for monetary policy with nominal-deficit targeting as a fiscal policy commitment. # O#cial text of the 2000 Money, Credit and Banking Lecture, presented at Ohio State University on May 1, 2000. I wish to thank Michael Bordo, Matt Canzoneri, Steve Cecchetti, Larry Christiano, John Cochrane, Paul Evans, Eduardo Loyo, Bennett McCallum, Helene Rey, Stephanie Schmitt-Grohe and Chris Sims for helpful discussions, Gauti Eggertsson for research assistance...
PENYULUHAN DEMAM BERDARAH DAN RESISTENSI INSEKTISIDA ANTINYAMUK DI DESA OEBELO, KABUPATEN KUPANG, NUSA TENGGARA TIMUR

Field: Health Professions (Health Sciences)

Dengue Hemorrhagic Fever in the east nusa tenggara currently dominates the third highest number in Indonesia. This outreach activity was carried out in Oebelo Village, Kupang Regency, East Nusa Tenggara Province on Dengue Hemorrhagic Fever and Anti-Mosquito Insecticide Resistance. The method used The method used in this extension is the lecture and discussion method. The purpose of this outreach is to provide information to the public about Dengue Hemorrhagic Fever and its control and control efforts with 4M. The conclusions obtained are increased understanding of the eradication of mosquito nests 4M plus, increased public understanding of the bioecological vectors that cause dengue fever, increased understanding of mosquito repellent insecticide resistance and possible uses as mosquito repellent insecticides.
Factors associated with insensitivity to pyridostigmine therapy in Thai patients with ocular myasthenia gravis.

Field: Medicine (Health Sciences)

The objective of this study was to determine factors associated with pyridostigmine therapy in patients with ocular myasthenia gravis (OMG). This retrospective study included eighty-five patients with OMG who have been treated with pyridostigmine. Patients were excluded if they were diagnosed as generalized myasthenia gravis within a month after diagnosis or were treated with other medications. Forty-two patients responded to pyridostigmine and 43 patients did not. There were no significant differences in gender, age, the duration of symptoms before treatment, the dosage of pyridostigmine, and the initial presentations of ptosis or diplopia between the two groups. However, an initial presentation of concurrent ptosis and diplopia and the presence of systemic involvement after follow up were significant factors associated with an insensitivity to pyridostigmine in patients with OMG (p = 0.001 and p = 0.01, respectively). Determining these factors could help predict the pyridostigmine response in patients with OMG.
Hyperactivity and impaired response habituation in hyperdopaminergic mice

Field: Neuroscience (Life Sciences)

Abnormal dopaminergic transmission is implicated in schizophrenia, attention deficit hyperactivity disorder, and drug addiction. In an attempt to model aspects of these disorders, we have generated hyperdopaminergic mutant mice by reducing expression of the dopamine transporter (DAT) to 10% of wild-type levels (DAT knockdown). Fast-scan cyclic voltammetry and in vivo microdialysis revealed that released dopamine was cleared at a slow rate in knockdown mice, which resulted in a higher extracellular dopamine concentration. Unlike the DAT knockout mice, the DAT knockdown mice do not display a growth retardation phenotype. They have normal home cage activity but display hyperactivity and impaired response habituation in novel environments. In addition, we show that both the indirect dopamine receptor agonist amphetamine and the direct agonists apomorphine and quinpirole inhibit locomotor activity in the DAT knockdown mice, leading to the hypothesis that a shift in the balance between dopamine auto and heteroreceptor function may contribute to the therapeutic effect of psychostimulants in attention deficit hyperactivity disorder.
Determination of the Crystal Structure of Human Zn-Alpha 2-Glycoprotein, A Protein Implicated in Breast Cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract : Zn-alpha 2-glycoprotein (ZAG) is a 41 kDa soluble protein whose sequence and domain organization are surprisingly similar to those of the membrane glycoproteins of the major histocompatibility complex (MHC). MHC molecules function in the presentation of peptide antigens to cytotoxic T cells during immune surveillance, but recent data indicate that ZAG stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. In addition, ZAG is found in high concentrations in 40% of mammary carcinomas, as well as in cysts from breast gross cystic disease. These data suggest that ZAG participates in the development of breast diseases including breast carcinomas. We purified ZAG from human serum and solved the crystal structure to 2.8 A resolution. ZAG resembles a class I major histocompatibility complex heavy chain, but ZAG does not bind the class I light chain beta 2-microglobulin. The ZAG counterpart of the MHC peptide binding groove contains electron density corresponding to a hydrophobic, non- peptidic compound that may be implicated in lipid catabolism under normal or pathological conditions. We have initiated mass spectrometry assays to identify the ligand and are testing the ability of hydrophobic small molecules to bind to serum-derived ZAG and to ZAG produced in bacteria, which presumably does not contain a hydrophobic ligand.
Differential expression of Lumican, Mimecan, Annexin A5 and Serotransferrin in ectopic and matched eutopic endometrium in ovarian endometriosis: a case-control study

Field: Medicine (Health Sciences)

Endometriosis is a debilitating disease marked by recurrent gynecological proliferations. The present study aimed at performing differential proteomic analysis of matched eutopic and ectopic endometrium from women with ovarian endometriosis. Proteomes were resolved using nano LC–MS and further identified and quantified using ProteinLynx Global SERVER (PLGS) software. Selected proteins were further chosen for validation by real time-polymerase chain reaction (RT-PCR). The protein profiles uncovered several differentially expressed proteins in the diseased sample (ectopic endometrium) as compared to the reference sample (eutopic endometrium). The study involved an advanced proteomic approach, nano LC–MS, and validates for the first time the upregulation of Mimecan and Lumican proteins in endometriosis. These proteins may hence prove as potentially useful tools in the search for diagnostic markers for early detection of the disease.
Hosted Formation of PbS Crystals on Polyethylene Modified Surface

Field: Materials Science (Physical Sciences)

Nanocristais inorgânicos estáveis e suportados, como PbS ou outros quantum dots, são materiais extremamente importantes quando obtidos na forma de filmes finos para a aplicação em áreas tecnológicas.Neste trabalho, um método para o crescimento de cristais de PbS sobre filme ultrafino de poli(ácido acrílico) (PAA) covalentemente imobilizado na superfície de polietileno (PE) é descrito.O método utilizado permite a obtenção de materiais com diferentes formas e tamanhos pelo ajuste de variáveis experimentais.Os compostos mais homogêneos e com as menores partículas foram obtidos em pH 6 devido a remoção mais lenta de íons Pb 2+ adsorvidos no filme ultrafino de PAA.Dessa forma, o PbS é formado in situ no interior do PAA.A análise da morfologia dos compósitos mostrou uma relação direta entre a concentração de Pb 2+ e a concentração de tioacetamida (TAA).Compósitos mais homogêneos com as partículas menores foram obtidos na condição de menor concentração de Pb 2+ e maior concentração de TAA ou na
Influence of Kori-tofu on Lipid and Sugar Metabolism

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Kori-tofu is a traditional food in Japan. Kori-tofu is known to decrease serum LDL-cholesterol and triacylglycerol. Kori-tofu also decreases HbA1c, indicating improved sugar metabolism. A dominant hypothesis regarding these phenomena is that the undigested protein fraction of kori-tofu (resistant protein) binds to bile acids in the intestine, preventing bile acid resorption. Recent studies have shown that bile acids are a type of signaling molecule that activates FXR and TGR5. This can explain why the binding activity of bile acid, involving resistant protein, relates to lipid and sugar metabolism. Resistant protein in kori-tofu is increased during its production process, including high-pressure treatment of fresh tofu, freezing and low-temperature aging. The abundance of resistant protein can explain the function of kori-tofu.
Gig-economy as a safety gradient for sustainable development of the mining industry

Field: Economics, Econometrics and Finance (Social Sciences)

Purpose. To evaluate causality of expanding the gig-economic space and the socioeconomic and ecological security of Ukraines mining industry in the context of the changing technological structures caused by the emergence of a new security structural and functional post Covid-19 component. To propose typical scenarios for sustainable development of the gig-economy in the context of improving security policy of Ukraines mining industry. Methodology. To achieve this goal, a scenario planning, Delphi, SMART, SWOT analysis and mathematical research methods econometric and gradient analysis, were used to determine the scalar values and directions of extreme innovative changes in the gig economy in the context of sustainable development of mining industry in Ukraine. The calculations were carried out using the SPSS Data Analysis Software. Findings. The work systematically analyzes key safety indicators of scientific-technological progress for sustainable development of the mining industry and establishes a one-to-one relationship between existing socio-economic phenomena and gig-economic processes, which in recent years have been asymmetrically activated under the influence of the post Covid-2019. The security specifics of tactical and strategic management of the gig-economy are outlined. Originality. A methodological approach to the quantitative and qualitative determination of the safety gradients of the development of the mining industry enables the consideration of transformational Post-Covid consequences, as well as diversifies tactical and strategic management. In particular, it is proposed to use an innovative digital platform CENSIE Central European Network for Sustainable and Innovative Economy. Practical value. A proposed approach would facilitate to improve the efficiency of strategic and tactical management of personnel policy of the mining industry in the context of the formation of a gig-economy, as well as synchronize time and space parameters, increasing the targeting of management decisions. It was proposed to introduce a special remote platform MiningFreelance to provide freelance services to households, family farms and other manufacturers which will be protected by the Blockchain registry based on existing ProZorro programs. At the same time, Blockchain technologies will increase the role of trade unions, which will be able to unite gig workers into a single system and control working conditions, taking on certain social obligations.
Some Ethical Problems in Special Education

Field: Arts and Humanities (Social Sciences)

Abstract This paper examines, from a philosophical perspective, some of the main ethical problems pertaining to the special education field. It is argued that while special education practice has been strongly grounded in psychological theory, it has not always been adequately justified by reference to general moral principles. Rationales for intervention are mostly couched in descriptive or explanatory terms while the over-riding prescriptive or evaluative dimensions are often presupposed without explicit justification. Particular issues such as diagnostic assessment, educational placement and behavioural management can be seen to entail complex ethical problems concerning the consideration of individual rights and interests, equality of educational opportunity, and respect for personal autonomy. Examples of the moral dilemmas inherent in particular special educational practices are examined. Finally, it is claimed that special educators must be able to defend not only the empirical bases of their educational theories, but also the value judgments implicit in them.
Localization of a receptor nonapeptide with a possible role in the binding of the type I interferons.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Interferons (IFNs) in common with other cytokines activate Janus tyrosine kinases and latent STAT transcription factors upon binding to their cell surface receptor. Type I IFNs bind to a receptor composed of two transmembrane polypeptides, IFNAR1 and IFNAR2, which belong to the class II cytokine receptor family that also includes the cellular receptors for IFN-gamma, interleukin-10 and coagulation protease factor VII (tissue factor). The extracellular domain of the type I IFN receptor chain IFNAR1, has four fibronectin type-III sub-domains. Human IFNAR1 has intrinsic weak affinity for type I IFNs and plays an essential role in transmembrane signaling, formation of a high affinity complex with IFN and the modulation of ligand specificity. In order to characterise the ligand binding site on IFNAR1 we analysed the epitope recognized by the anti-IFNAR1 mAb, 64G12, which inhibits the binding and biological activities of both IFN-alpha and IFN-beta. The target peptide recognized by the 64G12 mAb was determined by screening a set of 48 overlapping peptides covering the first two subdomains (residues 23-229) of the extracellular region of IFNAR1. The results of this study show that the peptide (FSSLKLNVY), localized within the first sub-domain (residues 89-97) of IFNAR1, which is recognized by the 64G12 mAb, most likely overlaps a site to which both IFN-alpha and IFN-beta bind in the ligand-receptor complex. Thus, since the 64G12 mAb can neutralize the biological activities of all the type I IFNs tested, we suggest that the target peptide recognized by the 64G12 mAb, is a possible anchorage point on IFNAR1, common to binding of both IFN-alpha and IFN-beta.
Systemin activates synthesis of wound-inducible tomato leaf polyphenol oxidase via the octadecanoid defense signaling pathway.

Field: Agricultural and Biological Sciences (Life Sciences)

Tomato plants overexpressing a prosystemin gene that encodes the precursor of a mobile wound signal called systemin have been shown previously to constitutively synthesize extraordinarily high levels of two defensive proteinase inhibitor proteins in leaves in the absence of wounding. We herein report that leaves of these transgenic plants possess enhanced levels of another defensive protein, polyphenol oxidase (PPO) at levels that are up to 70-fold higher than levels found in leaves of wild-type plants. Supplying young wild-type tomato plants with systemin through cut stems induced PPO activity in leaves, and wounding lower leaves of young tomato plants induced PPO activity in both wounded and unwounded leaves to levels equal to those induced by systemin. Exposing young tomato plants to methyl jasmonate vapor caused an increase in PPO activity equivalent to levels found in plants overexpressing the prosystemin gene. The data indicate that PPO and proteinase inhibitor genes are coactivated systemically by wounding via the octadecanoid signal transduction pathway and that systemin has a much broader role in signaling plant defensive genes than was previously known.
Multivariate Analysis Reveals a miRNA Profile Correlated To Karyotype and Outcome In Pediatric B-Cell Precursor ALL

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Acute lymphoblastic leukemia (ALL) is the commonest childhood cancer and is characterized by the presence of recurring structural genetic alterations that have been associated to clinical response.Recently it has been shown that the deregulation of microRNAs (miRNA), a class of small RNAs that negatively control gene expression, is a common characteristic of hematological malignancies and may be related to the pathogenesis of leukemias. The aim of the current study was to explore which microRNAs are expressed by each subtype of pediatric B-cell precursor ALL and to determine their roles into clinical outcome. We analyzed samples from 94 children diagnosed as B-cell precursor ALL in Italy between 2000 and 2010 that were included in the AIEOP-BFM protocol of treatment. The patients were divided by cytogenetic subgroups of ALL. Cells CD34+ and CD19+ from healthy donors were used as negative controls. The miRNA signature was studied using microchips for miRNA microarray. We first performed a two-class comparison of miRNA expression between leukemic and non-leukemic samples and found 84 miRNAs differently expressed (P<0.01). A multivariate analysis of karyotype showed that 59 of these miRNAs were correlated to leukemia (P<0.01). All major subtypes of precursor B-cell ALL were analyzed: MLL-rearranged (10), TEL-AML1(15), E2A-PBX1(10), BCR-ABL(23), hyperdiploid(17), ‘normal Karyotype’ (19, defined as those not carrying the foregoing cytogenetic aberrations), and also the presence of IKAROS deletions was evaluated. Each subgroup was found to have unique microRNA-signature that differed from each other and from those of healthy hematopoietic cells. Both Kaplan Meier and Cox regression tests were performed to check how many of these miRNAs were correlated to clinic response, based on the induction failure, relapse, and survival. A multivariate analysis revealed that genetic subtypes and poor-responders patients display characteristic miRNA signatures. Specifically the mir-125b, 16-2, 24, 28-5p, 128a, 138-1 and 658 (all P<0.01) came out as independent prognostic factors predictive of event-free survival (EFS). IKAROS deletions did not come out as an independent prognostic factor, probably for being already associated to Ph+ and “BCR-ABL like” patients, who already have a poor prognosis. In addition, our group has previously shown that miR-125b may act as an oncogene and is correlated to a poor response in Ph+ samples, also increasing therapy resistance and leukemia aggressiveness in vivo. Further functional studies are needed to better explain the role of these miRNA and to provide new insights into the biology of pediatric ALL. Disclosures: Garzon: Karyopharm : Research Funding.