jimnoneill/paper-to-field-training huggingface dataset:
Antidiabetic effects of marine brown algae Spatoglossum asperum J. Ag. ethanolic extract on 3T3-L1 Pre-Adipocytes activity an in vitro approach

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Marine algae have emerged as good alternative source of medical, pharmaceutical, and food industries, it’s used for anticancer, anti-inflammatory, antioxidant, antimicrobial, etc., In this study, anti-diabetic effect of brown seaweed Spatoglossum asperum was focused, We aimed systematically to examine the ethanolic extract effects of S. asperum (EESA) as an anti-diabetic agent using 3T3-L1 in vitro assay, focused through molecular works; protein extraction, DNA isolation, gene analysis, western blot, ROS measurement, senescence associated β-galactosidase and deoxy glucose uptakes. In results for p21/β-actin H2O2+EESA treated cells showed very good potential results showed (0.44), same combination reduced the toxic level (0.60) in p53/β-actin, awfully superior results showed (0.39) in p16/β-actin. In adiponectin (1.16), tnf-α (0.68), il6 (0.42), RFU (211.5), same combination in COMET assay observed that DNA damage (4.95), glucose uptake noticed (68.45%), mRNA expression in p53 showed (0.07), p21 (1.8), adiponectin (3.25), tnf-α obtained (1.95), il6 expression obtained (2), p16 expression (2). From the results concluded that the capability to supplement glucose absorption in 3T3-L1 pre-adipocytes and augment glucose consumption activity through the appearance of glucose transporter type 4 (GLUT 4).
Comparison of Y1 mouse adrenal cell and coagglutination assays for detection of Escherichia coli heat labile enterotoxin.

Field: Immunology and Microbiology (Life Sciences)

A commercial coagglutination assay (COA; Phadebact LT-ETEC) was compared with a Y1 mouse adrenal cell assay for detecting the heat labile enterotoxin of Escherichia coli. Of four different media evaluated for use with the COA, only one (modified blood agar) gave a positive result with all strains known to produce heat labile enterotoxin. With modified blood agar, the COA detected 74 (85%) of 87 such strains. Eighty six strains negative by cell culture assay were also negative by COA, and one strain positive by COA could not be confirmed by cell culture. The Phadebact LT-ETEC kit provides a simple, sensitive, and economical method for detecting E coli heat labile enterotoxin.
STATE PENSION INSURANCE IN UKRAINE: MODERN CHALLENGES AND DIRECTIONS OF REFORM

Field: Economics, Econometrics and Finance (Social Sciences)

Introduction. Reforming the pension system in Ukraine is associated with the need to introduce a second funded level of pension insurance in the face of a steady deficit of the Pension Fund, the presence of significant shortcomings in the mechanism for calculating pension payments that do not depend on the volume of contributions paid for compulsory state pension insurance of the level of pensions, the level of which in the conditions the constant rise in prices for essential goods and services causes the impoverishment of the population. The purpose of the article is to conduct a comprehensive analysis of the domestic practice of generating budget revenues for the Pension Fund of Ukraine and spending in the context of permanent changes in the country, identify the main trends and challenges and determine the main directions for reforming the pension system of Ukraine. Results. An analysis was made of the domestic practice of generating budget revenues for the Pension Fund of Ukraine in the context of a reduction in incomes of the population due to quarantine measures due to the spread of COVID-19, job losses, crisis phenomena in the country's economy, as well as additional items of expenditure of the Pension Fund budget aimed at material support of citizens retirement age. The shortcomings of the current practice of functioning of the solidary system of pension insurance are identified. Conclusions. Substantiated proposals for the effective implementation of the second funded level of the pension insurance system in Ukraine. It has been determined that the combination of a solidary and funded pension insurance system in today's conditions is the best option, since it will diversify various types of risks and provide basic types of pensions.
Ethno-Cultural and Religious Grounds for Cognition and Education

Field: Arts and Humanities (Social Sciences)

The article, on the basis of "cognitive culture" concept, considers the influence of ethno-cultural and religious conscience on the peculiarities of cognitive and educational activity of people from North Caucasus and Daghestan.At the same time tendencies of spiritual life of the peoples of the republic are compared with postmodernist orientation in modern culture, as well as the revealing of common and opposite vectors in their development.
Valvular Endocarditis and Biventricular Heart Failure in the Setting of Tropheryma whipplei Disease

Field: Medicine (Health Sciences)

Abstract Whipple disease is a rare systemic illness associated with weight loss, diarrhea, and arthralgia. Asymptomatic carriage is common, but the disease can be complicated by cardiac involvement and may result in culture-negative endocarditis. Cardiac manifestations of the disease can lead to death. This report presents the case of a 66-year-old man with Whipple disease and biventricular heart failure with cardiogenic shock. Medical therapy followed by successful replacement of the aortic and mitral valves resulted in substantial improvement.
OXIDATION FLUX CHANGE IN DIABETIC RETINOPATHY: DOES IT EXIST OR NOT?

Field: Medicine (Health Sciences)

SUMMARY The oxidation process is one of the most important natural processes. Oxidative change in retina is believed to be an important process in the pathogenesis of diabetic retinopathy. In the present study, the oxidation flux change was assessed in such cases. The simulation test to determine the oxidation flux change based on nanomedicine technique was used. Of interest, no flux change could be detected. The main pathogenesis should be direct injury of membrane structure by other processes. Therefore, study results support the concept according to which the oxidation flux change in basement membrane does not exist.
High phylogenetic diversity of the cat flea ( Ctenocephalides felis ) at two mitochondrial DNA markers

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract The cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae) (Bouché), is the most common flea species found on cats and dogs worldwide. We investigated the genetic identity of the cosmopolitan subspecies C. felis felis and evaluated diversity of cat fleas from Australia, Fiji, Thailand and Seychelles using mt DNA sequences from cytochrome c oxidase subunit I ( cox1 ) and II ( cox2 ) genes. Both cox1 and cox2 confirmed the high phylogenetic diversity and paraphyletic origin of C. felis felis . The African subspecies C. felis strongylus (Jordan) is nested within the paraphyletic C. felis felis . The south East Asian subspecies C. felis orientis (Jordan) is monophyletic and is supported by morphology. We confirm that Australian cat fleas belong to C. felis felis and show that in Australia they form two distinct phylogenetic clades, one common with fleas from Fiji. Using a barcoding approach, we recognize two putative species within C. felis ( C. felis and C. orientis ). Nucleotide diversity was higher in cox1 but COX2 outperformed COX1 in amino acid diversity. COX2 amino acid sequences resolve all phylogenetic clades and provide an additional phylogenetic signal. Both cox1 and cox2 resolved identical phylogeny and are suitable for population structure studies of Ctenocephalides species.
[Diabetes mellitus and periodontal diseases].

Field: Medicine (Health Sciences)

Opinions on the interdependence between diabetes mellitus and oral periodontal disease are controversial. Experimental and clinical investigations carried out so far have not brought unique results. General objective of our research is to investigate on the strictly defined group of subjects aged 35-44 with diabetes mellitus type I the influence of metabolic control HbA1C on changes of periodontium and other organs. According to duration of diabetes mellitus the patients are divided into subdecade and postdecade groups. This group consists of 56 patients out of which 33 patients are with subdecade and 23 with postdecade insulin-dependent diabetes mellitus. In this group periodontal pocket depths, gingival index, number of extracted teeth and the volume of nonstimulated saliva are measured in comparison with a control group. The incidence of oral diseases and complications in other organs of insulin-dependent patients in subdecade and postdecade period are also examined and recorded. Periodontal diabetic disease is verified by pathohistological findings. Values of HbA1C in either subdecade or postdecade group with diabetes mellitus are above normal values. Values of periodontal pocket depths as well as the values of gingival index are substantially greater at insulin-dependent diabetes mellitus patients compared to the control group.
Factors influencing the keeping qualities of apples in cold storage /

Field: Agricultural and Biological Sciences (Life Sciences)

VerLi aiderr ¥ 4These figures look very favorable to the grower.However, not all of the crop is fit for barrel stock and it costs nearly as much to raise the poor fruit as it does the good.Estimates of commercial apple crops are given by Mr. E. J. Glasson (8,a) (8,b
Fullscreen : a campaign to empower Smart Digital Parents

Field: Social Sciences (Social Sciences)

This report presents Fullscreen, an educational campaign to promote parent-child interaction in the mediation of their child’s digital device usage. The campaign is initiated by four final-year students from the Wee Kim Wee School of Communication and Information, Nanyang Technology University. Fullscreen targets Singaporean parents with children aged 7-12 years old, to address their lack of confidence and knowledge about adopting parental mediation strategies to mediate their child’s digital device usage. Based on primary and secondary research guided by Primary Socialization Theory, Parental Mediation Theory, and the Theory of Planned Behavior, we developed the big idea of Balance, Communicate, and Role Model. Our message advocated to parents a three-pronged approach of restrictive mediation, active mediation, and co- use. We disseminated our message to our target audience through online and on-ground engagement activities conducted from January through March 2018. Our online video series and social media platforms contained educational information to raise parents’ knowledge and skills. We developed Fullscreen Prompts, a card deck distributed at six roving pop-ups held at community events. Based on the outcome evaluation results, parents exposed to the campaign showed an overall increase in (a) awareness of the three-pronged approach, (b) confidence in mediating their child’s digital device usage, (c) attitudes towards the three-pronged approach, and (d) intentions and behaviors to practice the three-pronged approach, as compared to non- exposed parents. A discussion on the campaign and its sustainability are included thereafter. Original documents and relevant data are included in the appendices as references to the main paper.
Corporate Governance of Sustainable Artificial Intelligence (AI) in Strategic Communication (SC) and Digital Marketing (DM)

Field: Business, Management and Accounting (Social Sciences)

The discourse on the ethics of artificial intelligence (AI) is increasing, which renders the concept of “AI ethics” vague and difficult to implement. Nevertheless, AI ethics are closely associated with strategic communication in public relations and digital marketing. The current study aims to identify the features of the institutional framing of (AI) sustainability ethics through textual analysis of a UAE Code of Ethics. The study belongs to pilot and analytical studies within the scope of ethical use of AI in strategic communication and digital marketing. The research initially included secondary research where qualitative data has been collected for designing research questions regarding the institutional framing of sustainable AI as a framework for strategic communication and digital marketing in the United Arab Emirates. Mixed method of data collection adapted using the textual analysis form and content analysis form to collect data about the priorities and frame that were relied upon in the study sample. The researcher developed a scale consisting of 10 categories to determine the frames and priorities of the institutional framing for responsible AI in the United Arab Emirates.
HUBUNGAN ANTARA KADAR HEMOGLOBIN DAN STATUS GIZI DENGAN GANGGUAN SIKLUS MENSTRUASI PADA SISWI

Field: Medicine (Health Sciences)

Background: Menstrual disorders often occur in adolescents, in the world the prevalence of menstrual cycle disorders in early adolescent women is around 45%, menstrual disorders can be serious. can be a sign of no ovulation, heavy bleeding and occurs over a long period of time can cause anemia in adolescents factors related to menstrual cycle disorders include stress, nutritional status, hemoglobin levels, physical activity, and sleep duration. Purpose: This study aims to determine the relationship between hemoglobin levels and nutritional status with menstrual cycle disorders in SMK students. Methodology: This study is a quantitative research that is correlational, the method used is non-experimental with cross sectional. The sample in this study amounted to 70 respondents, female adolescent students in grades X-XII. The sampling technique used purposive sampling technique, using the Chi square test. Research Results: Univariate results showed that the majority of respondents did not experience menstrual cycle disorders 57.1%, the majority of normal hemoglobin levels 70% and the majority of normal nutritional status (58,6%. Bivariate results show a relationship between hemoglobin levels (p-value = 0.018) and nutritional status (p-value = 0.004) with menstrual cycle disorders. Conclusion: there is a relationship between hemoglobin levels and nutritional status with menstrual cycle disorders in female students of SMK. Suggestion: Young women need to consume iron supplements regularly and their nutritional status should remain in the normal category, namely by maintaining a healthy diet, exercising regularly so that their nutritional status is normal and their hemoglobin levels are normal and not anemic.
Utility of presepsin (sCD14-ST) as a diagnostic and prognostic marker of sepsis in the emergency department

Field: Medicine (Health Sciences)

Presepsin (PSEP) is released during infectious diseases and can be detected in the blood. PSEP has shown promising results as sepsis marker. We examined the diagnostic and prognostic validity of PSEP in patients suspicious of sepsis on admission in the emergency department (ED).One hundred twenty three patients with signs of SIRS and/or sepsis and 123 healthy individuals were enrolled. PSEP was determined on admission, after 8, 24 and 72 h.Mean PSEP concentrations of the control group and the patient group were 130 and 1945 pg/ml. PSEP differed between SIRS, sepsis, severe sepsis and septic shock and showed strong association with 30-day mortality ranging from 10.3% in the 1st to 32.1% in the 4th quartile. The ROC curve analyses revealed an AUC value of 0.743. Combined assessment of PSEP and MEDS score increased the AUC up to 0.878 demonstrating the close relationship with outcome. Based on the PSEP values in the different severity degrees, decision thresholds for risk stratification were established. The course of PSEP during the first 72 h was associated with effectiveness of treatment and outcome.PSEP allowed outcome prediction already on admission to a similar degree as the clinical scores MEDS and APACHE II. Combination of PSEP with MEDS score improved the discriminatory power for outcome prediction.
Effects of γ-poly(glutamic acid) on Lychee Fruit shelf-life during normal temperature storage

Field: Agricultural and Biological Sciences (Life Sciences)

To improve the shelf-life period and the freshness quality of Lychee Fruit,γ-poly(glutamic acid),a high-molecule biomaterial,was coated on litchi for fresh keeping and stored at normal temperature. The changes of physiological characteristics in storage were studied. The results showed that the treatment of 6g/L γ-PGA could lessen the loss of water content of litchi pericarp,remarkably degrade the respiration rate and the ethylene production rate,slow down the degradation of anthocyanin content,decrease of PPO and POD activities in the pericarp. This method could prolong the fresh-keeping period about 4 days of Lychee Fruit.
Blood pressure changes in patients after minoxidil microinfusion to treat female pattern alopecia: analysis of a randomized, single blinded, placebo controlled clinical trial

Field: Medicine (Health Sciences)

Abstract

Background Microinfusion is a superficial microneedling procedure that infuses medications into the surface of the dermis through disposable needles attached to tattoo equipment. Various medications can be microinfused; minoxidil is frequently utilized as an adjuvant treatment for androgenetic alopecia, but little data is available on its systemic effects when administered via this technique. Objective To compare blood pressure readings before and after microinfusion of minoxidil in the scalp to assess this drug’s systemic effects when applied using this technique. Methods This randomized, controlled, blinded study was conducted with 24 patients divided into 2 groups to compare microinfusion with 0.5% minoxidil and saline solution (control group). Participants underwent 3 sessions at monthly intervals, and their blood pressure was measured before and after each microinfusion procedure. Results A statistically significant reduction in diastolic blood pressure was observed after the procedure in the minoxidil group (p = 0.037). In the control group, a statistically significant increase in systolic blood pressure was found (p = 0.013). Conclusion Reduction of diastolic blood pressure in the minoxidil group proved dermal delivery and systemic absorption of the medication after scalp microinfusion. Increased systolic pressure in the control group may be related to pain during the procedure.
Exploring How Aerosol Optical Depth Varies in the Yellow River Basin and Its Urban Agglomerations by Decade

Field: Environmental Science (Physical Sciences)

In this study, the spatial–temporal characteristics of AOD in the Yellow River Basin (YRB) and urban agglomerations within the basin were analyzed at a 1 km scale from 2011 to 2020 based on the MCD19A2 AOD dataset. This study shows the following: (1) From 2011 to 2020, the AOD value of the YRB showed a declining trend, with 96.011% of the zones experiencing a decrease in AOD. The spatial distribution of AOD displayed a pattern of high in the east, low in the west, high in the south, and low in the north. The rate of decline showed a distribution pattern of fast in the southeast and slow in the northwest. (2) The AOD in the YRB showed similar characteristics in different seasons: the south and east were consistently higher than the north and west. The seasonal AOD values in the YRB showed the following pattern: summer > spring > autumn > winter. The AOD values of urban agglomeration were basically larger in spring and summer. (3) The SDE and mean center of the yearly AOD were located in the southeast and Shanxi Province, with the movement from southeast to northwest. It can be divided into three stages based on the movement trajectory: northeast–southwest round-trip movement (2011–2014), one-way movement to the northwest (2014–2018), and southeast–northwest round-trip movement (2018–2020).
Giving an account of entrepreneurial subjects and global spaces: social media and Colombian cosmetic surgery

Field: Social Sciences (Social Sciences)

Cosmetic surgery tourism portrays the recipients of cosmetic surgery as subjects who must work on themselves by investing in surgical means of self-transformation and self-refinement. However, little research explores how cosmetic surgeons position themselves in such aesthetic ventures through advertising themselves online. Drawing upon ethnographic methods and theoretical contributions from governmentality studies, this thesis explores how cosmetic surgeons in Colombia, an increasingly popular destination for cosmetic surgery tourism, come to be “entrepreneurs of themselves” through performing governmental discourses of neoliberalism and globalization. I present findings from a research project that incorporates 20 interviews with cosmetic surgeons in the cities of Barranquilla, Cali, and Bogota. By analyzing participants’ understandings of what compels, complicates, and contests such entrepreneurial practices, I discuss how governmental discourses enable yet constrain the very subjects that are produced in such relations of power. This thesis thus examines the performativity of ethical practices and technologies of the self, thereby further developing an analysis of both the everyday and imminent forms of conducting oneself in a proliferating “global” economic sphere.
Heterozygous Orthodenticle Homeobox 2 Mutations Are Associated with Variable Pituitary Phenotype

Field: Medicine (Health Sciences)

ABSTRACT Context Although recent studies have suggested a positive role of OTX2 in pituitary as well as ocular development and function, detailed pituitary phenotypes in OTX2 mutations and OTX2 target genes for pituitary function other than HESX1 and POU1F1 remain to be determined. Objective We aimed to examine such unresolved issues. Subjects We studied 94 Japanese patients with various ocular or pituitary abnormalities. Results We identified heterozygous p.K74fsX103 in case 1, p.A72fsX86 in case 2, p.G188X in two unrelated cases (3 and 4), and a 2,860,561-bp microdeletion involving OTX2 in case 5. Clinical studies revealed isolated GH deficiency in cases 1 and 5; combined pituitary hormone deficiency in case 3; abnormal pituitary structures in cases 1, 3, and 5; and apparently normal pituitary function in cases 2 and 4, together with ocular anomalies in cases 1-5. The wild-type Orthodenticle homeobox 2 (OTX2) protein transactivated the GNRH1 promoter as well as the HESX1, POU1F1, and IRBP (interstitial retinoid-binding protein) promoters, whereas the p.K74fsX103-OTX2 and p.A72fsX86-OTX2 proteins had no transactivation functions and the p.G188X-OTX2 protein had reduced (∼50%) transactivation functions for the four promoters, with no dominant-negative effect. cDNA screening identified positive OTX2 expression in the hypothalamus. Conclusions The results imply that OTX2 mutations are associated with variable pituitary phenotype, with no genotype-phenotype correlations, and that OTX2 can transactivate GNRH1 as well as HESX1 and POU1F1.
SH1792745.08FU

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.