jimnoneill/paper-to-field-training huggingface dataset:
Intestinal and serum antibody responses in mice after oral immunization with Salmonella, Escherichia coli, and Salmonella-Escherichia coli hybrid strains

Field: Immunology and Microbiology (Life Sciences)

After oral feeding of mice with avirulent Salmonella, Escherichia coli, or hybrid strains, only certain bacterial strains were able to multiply and persist within the small intestinal Peyer's patches. After oral vaccination alone, or oral priming and subsequent parenteral boosting, antibody class and titers were detected, using a radioimmunoassay on serum and intestinal fluid or a plaque-forming cell assay on spleens. Only those strains that persisted in the Peyer's patches stimulated the production of serum and intestinal immunoglobulin A antibodies against their respective O antigens. Nonpersistent strains were weakly immunogenic, and antibodies, when present, were largely non-immunoglobulin A and confined to the serum.
Implementation and use of mHealth home telemonitoring in adults with acute COVID-19 infection: a scoping review protocol

Field: Health Professions (Health Sciences)

Introduction mHealth refers to digital technologies that, via smartphones, mobile apps and specialised digital sensors, yield real-time assessments of patient’s health status. In the context of the COVID-19 pandemic, these technologies enable remote patient monitoring, with the benefit of timely recognition of disease progression to convalescence, deterioration or postacute sequelae. This should enable appropriate medical interventions and facilitate recovery. Various barriers, both at patient and technology levels, have been reported, hindering implementation and use of mHealth telemonitoring. As systematised and synthesised evidence in this area is lacking, we developed this protocol for a scoping review on mHealth home telemonitoring of acute COVID-19. Methods and analysis We compiled a search strategy following the PICO (Population, Intervention, Comparator, Outcome) and PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendation for Scoping Reviews) guidelines. MEDLINE, Embase and Web of Science will be searched from 1 March 2020 to 31 August 2021. Following the title and abstract screening, we will identify, systematise and synthesise the available knowledge. Based on pilot searches, we preview three themes for descriptive evidence synthesis. The first theme relates to implementation and use of mHealth telemonitoring, including reported barriers. The second theme covers the interactions of the telemonitoring team within and between different levels of the healthcare system. The third theme addresses how this telemonitoring warrants the continuity of care, also during disease transition into deterioration or postacute sequelae. Ethics and dissemination The studied evidence is in the public domain, therefore, no specific ethics approval is required. Evidence dissemination will be via peer-reviewed publications, conference presentations and reports to the policy makers.
A1059. TOTAL HIP ARTHROPLASTY FOLLOWING ACETABULAR FRACTURE

Field: Medicine (Health Sciences)

The purpose of this study was to review the clinical and radiographic outcome in THRs done following acetabular fractures (fx). All patients undergoing conversion THR after previous acetabular fx between 1990 and 2006 at a single institution were identified.

Clinical evaluation was done using the Harris hip scale. Radiographic evaluation was done using the system proposed by the Hip society. THRs as part of initial treatment for acute acetabular fx were excluded.

There were 90 THRs (90 patients) performed in patients previously treated for an acetabular fracture. At the time of their acetabular facture, 67 had been treated with ORIF, 12 were treated with closed or limited open reduction and percutaneous fixation, and 11 were treated without surgery. The mean age at injury was 43.7 years, (range, 14–79). 68 patients sustained their fx from a high-energy mechanism (MVC, MPC, or MCC).

Three patterns accounted for 52% of the fx: transverse posterior wall (20), both column (18), and T-Type (9). Associated pelvic fractures were present in 14 patients. Associated ipsilateral proximal femur fractures were present: femoral head (four), femoral neck (five), and femoral shaft (three). Among those treated with ORIF, marginal impaction was noted in 31 and osteo-chondral head damage in 32 hips.

The mean interval between injury and THR was 42 months (range, two months to 32 years). Cement-less fixation was used in 81 of the 90 cups. Similarly, cementless stems were used in 80 stems. Bone graft was necessary in 26 patients (17 autograft, nine allograft). Two cases each required pelvic augments and reinforcement cage, respectively.

Additional findings at THR included: femoral head erosion (53 hips), femoral head osteonecrosis (37 hips), osteonecrosis of the acetabulum (22 hips), and fx non-union (six hips). The average cup abduction angle was 440 (range, 28 to 60), the average cup height was 24 mm (range, 10 to 42), and the average medialization distance was 23 mm (range, 5 to 48). The mean EBL was 810 ml and mean operative time was 195 minutes. The mean F/U was 36 months (range, 6 months to 17 years). The median Harris hip score was 89 at the most recent F/U. Fifteen revisions (16%) have been done: aseptic loosening (seven hips), recurrent dislocation (six hips) and infection (two hips).

Five of the six revisions for recurrent dislocation were performed in patients who had a posterior approach for both their acetabular fracture treatment and their THR. No revision was done in those who had been initially with percutaneous fixation. There was no infection in those who had been initially with percutaneous fixation either from the fx treatment or the THR. In contrast, 14 ORIF patients were complicated by infection. One of these developed infection following THR.

Our data support the clinical efficacy and mid-term durability of THR in this patient group. Aseptic loosening and recurrent dislocation remain the primary reasons for revision surgery.
The Mechanism of Locomotion in the Leech (Hirudo Medicinalis Ray)

Field: Neuroscience (Life Sciences)

ABSTRACT Considerable uncertainty still exists concerning the nature of the mechanism which maintains the normal locomotory rhythm of terrestrial animals. Two types of theory have been advanced: (i) That the rhythm is determined by the existence of a closed chain of peripheral reflexes, each phase of a complete locomotory cycle setting up automatically the particular pattern of peripheral stimulation requisite for the elicitation of the succeeding phase in the cycle, (ii) That the rhythm is, fundamentally, a property of the central nervous system which is, however, susceptible to modification or extinction by peripheral stimulation.
P2-34-01 - Impact of community gardens in promoting sustainable lifestyles in urban settings: design and baseline data of the JArDinS study.

Field: Social Sciences (Social Sciences)

IntroductionDespite growing evidence for the multiple health benefits of community gardening, longitudinal studies based on quantitative data are needed. JArDinS is a quasi-experimental study aimed at assessing the impact of community garden participation (a natural experiment) in the adoption of more sustainable lifestyles.Materials and MethodsGardeners starting gardening in a community garden in Montpellier (France) were recruited in 2018 (natural experiment group). Volunteers with no experience in community gardening and matched for age range, gender, household income and household composition were recruited in a control group. A recruitment goal of 80 participants per group was determined to detect a 30% increase in F&V supply in the gardeners group.Participant were issued with three tools: a Food Supply Dairy to collect data on monthly householdu2019s food supply, a triaxial accelerometer (Actigraph) to measure physical activity and an online questionnaire on mental and social health, sensitivity to food waste, and connection with nature. The sustainability of lifestyles is examined by considering conjointly the three dimensions of sustainability:1) Social/health u2013 measured by nutritional quality of householdu2019s food supply, physical activity, mental well-being and social connection.2) Environment u2013 measured by environmental impact of householdu2019s food supply and related food trips, concern for food waste and connection with nature.2) Economy - measured by household food expenditure and the budget share of each food group and subgroup.Measures have been collected at baseline and will be repeated 12 months later. Change of outcomes after 1 year will be compared between the natural experiment and the control groups, to evaluate the effect of access to a community garden on the sustainability of lifestyles.ResultsA final number of 75 participants per group were enrolled at baseline, which is 6% less the original recruitment goal. Baseline data for the natural experiment group and the control group are currently being analysed and will be presented.DiscussionThis study will provide valuable information about the potential of community gardens to favor sustainable lifestyles, based on a robust quasi-experimental design allowing causality evaluation.Conflict of interest:There is no conflict of interest
Airweapon injuries in children: a case for

Field: Medicine (Health Sciences)

SUMMARY Theresults ofthefirst 6monthsofa2-year prospective study on thefrequency, severity andmethods ofprevention ofair weapon injuries tochildren arereported. Twenty-eight casespresenting toan urbanpaediatric accident andemergency department havebeen analysed. Nineteen ofthese were malesbetween theagesof10and16years.Atleast 18 incidents occurred inpublic places. Thefive mostserious injuries were oftheorbit, face andabdomen. Another nineinjuries were nearvital structures. Education isneeded on theexisting guidelines forthesafe use ofair weapons.
Enchanced Traffic Privacy For Data Leakage Using Ip Spoofing And Agent Guilt Model

Field: Computer Science (Physical Sciences)

With recent experimental works, it is found that there is a information leakage in the packetized flow of data due to user activity and traffic content within an organization. We aim at understanding how complex when the information leaked by packet traffic features namely packet length, direction and times. Technique to call this type of feature is called traffic masking. Here, we define a security model to find the ideal target of masking which removes any leakage. Major findings are that 1) Masking is a security model to find the ideal target of masking and it removes the leakage of packets in the network and 2) IP address Spoofing or IP Spoofing creates an Internet Protocol (IP) packets with a source IP address, for the purpose of concealing the identity of the sender or impersonating another computing system, and 3) Guilt Model Identified the probability of leaker and their details. A Data distributor has given sensitive data to supposedly trusted agents and those trusted employee’s leaks the confidential information to unauthorized party for the need of money. The distributor must assess the likelihood that the leaked data came from one or more agents, as opposed to having been gathered by other independent means. Hence we design in such a way that the data on reaching any destination say agent or unauthorized party, data as well as the IP address of the receiver will reach the distributor. If the distributor receives an IP address other an agent’s address, the distributor finds out that the data has been leaked. Fake object is inserted along with the data at the time of distribution for detecting the guilty agent. From the data received, the distributor compares with his database and finds out which agent has leaked the data by calculating the probability for each agent on the leaked data and when the information is leaked by the agent and the data which is made on the process will be again rolled back to the distributor successfully. For the need of security by IP spoofing ,only the agents can use their given system IP address by admin and they can’t use the some other IP’s.
PROBLEMS OF IMPROVING THE SCIENTIFIC-METHODICAL BASIS OF INCREASING THE EFFICIENCY OF INDUSTRIAL ENTERPRISES

Field: Business, Management and Accounting (Social Sciences)

This article analyzes the methodological aspects of evaluating the efficiency of innovative management of enterprises based on the systematic analysis of the efficiency indicators of industrial enterprises. The article also presents the factors affecting the efficiency of innovative management of industrial enterprises, based on grouping them according to the spheres of influence, a scientific proposal and practical recommendations aimed at increasing the efficiency of innovative management of industrial enterprises have been developed.
Interactive Multimedia with Episodic Mapping Strategy for Teaching Short Story Writing to Grade XI

Field: Arts and Humanities (Social Sciences)

This research was conducted to find out the results of the initial trials of interactive multimedia for learning to write short stories for eleventh grade high school students. This research is a development research that refers to the step of Borg & Gall's development model, which is carried out through several stages, namely: (1) needs analysis, (2) planning, (3) the development of several initial products, and (4) trials. The subject of field trials was 15 students. Data was collected by questionnaire of product trials to determine the response of students after using interactive multimedia in learning to write short stories developed. The results of the research are as follows: (1) The needs include the availability of learning media to write short stories that are new, interesting, appropriate, facilitate and motivate students to carry out short story writing learning. The weakness of students is that they are less able to find and develop ideas into several good paragraphs. The desire of teachers and students is the existence of learning media that can help students in writing short stories. (2) This interactive multimedia development product consists of short story text material. This strategy episodic mapping can really help students develop ideas because in this episodic mapping students are guided to determine intrinsic elements in short stories. (3) The final product fulfills the qualification of product feasibility as indicated by the results of the student response questionnaire that interactive multimedia with strategy episodic mapping is developed on the aspect of display quality in the "good" category with a score of 4.00, on the quality aspect of product presentation with the category "good "Score 4.00, and product benefits with a score of 4.3" good "category. From the results of interactive multimedia validation with strategy episodic mapping for learning to write short stories, it is very helpful for students to write short stories. Interactive multimedia with this strategy episodic mapping can be an alternative source of learning in writing short stories.
Depth of radiographic response (DpR) and time to tumor regrowth (TTG) to predict overall survival following anti-VEGF therapy in recurrent glioblastoma.

Field: Medicine (Health Sciences)

2063 Background: Anti-angiogenic therapies, anti-VEGF agents, cause high radiographic response rates due to reduction in vascular permeability. However, we theorized the degree of tumor shrinkage combined with the duration of response might be a more meaningful measure of tumor control and may better reflect real patient benefit. In the current study, we investigate the association between model-derived parameters describing enhancing tumor volumetric dynamics and overall survival (OS) in recurrent glioblastoma treated with anti-VEGF therapy from multiple clinical trials. Methods: N=134 patients treated with bevacizumab +/- irinotecan (BRAIN Trial; NCT00345163) and N=121 patients treated with cabozantinib (XL184-201; NCT00704288) were used to identify potential imaging biomarkers, and N=63 patients in the bevacizumab control arm in a phase III trial (GLOBE Trial; NCT02511405) were used as a validation dataset. Enhancing tumor volumes were estimated using T1 subtraction maps, and a biexponential model was used to model tumor response ( d) and regrowth ( g) rates, as well as time to tumor regrowth ( TTG), the inflection point where the tumor stops shrinking and starts to regrow, and the depth of response ( DpR) after initiation of anti-VEGF therapy for each patient. Log-rank, univariate, and multivariable Cox regression were used to quantify the relationship of these parameters and OS. Results: Optimized thresholds based on maximum hazard ratio occurred at d =0.11 months -1 ( P=5x10 -9 training; P=0.0082 validation); g=0.07 months -1 ( P=5x10 -20 training; P<0.0001 validation); TTG of 3.8 months ( P=6x10 -17 training; P<0.0001 validation); and DpR of 11.3% ( P=0.0026 training; P=0.0177 validation). Univariate and multivariable Cox regression using these thresholds and controlling for age and baseline tumor volume confirmed that d, g, TTG, and DpR were all significant and independent predictors of OS in both phase II training and phase III validation datasets ( P<0.01). Additionally, patients exhibiting combinations of a high DpR and/or long TTG showed differential median OS, while patients with favorable diffusion MR phenotypes exhibited a longer OS and significantly longer TTG. Conclusions: Volumetric response and regrowth rates, TTG, and DpR using a biexponential model are significant and independent predictors of OS in recurrent glioblastoma treated with anti-VEGF therapy. Clinical trial information: NCT00345163 ; NCT00704288 ; NCT02511405 .
Who you know, what you know and knowing the ropes: a review of evidence about access to higher education institutions in England

Field: Social Sciences (Social Sciences)

This paper considers the history of access to higher education in England and reviews the evidence on the progress made in widening participation and ensuring ‘fair access’ under the New Labour governments of 1997–2010 and, insofar as is possible, under the Coalition government that has been in office since 2010. While recognising that we need also to consider the nature of what students gain access to, the focus of this particular review is on evidence about inequalities in access to higher education as presently constituted, including in particular access to what are often regarded as the most ‘prestigious’ institutions. The paper considers the various ‘barriers’ to widening participation that are said to exist—from finance, aspiration and awareness and prior attainment—and assesses claims that socio‐economic inequalities in access largely disappear once prior attainment is taken into account. It then discusses the role of social and cultural capitals in perpetuating inequalities both in prior attainment and access to higher education in its various forms. The importance of ‘knowing the ropes’ is highlighted and the paper ends with a discussion of the implications of the findings of the review for future approaches to policy and research in this field.
Perencanaan dan Pembuatan Sistem Deteksi Tingkat Kelelahan Pada Pengemudi Kendaraan Bermotor

Field: Engineering (Physical Sciences)

Traffic accidents on the highway are common. One of the causes is the fatigue factor of the driver so that his driving concentration will decrease. The condition of fatigue in the driver occurs due to decreased levels of oxygen in the blood (SpO2). This application to monitor the driver's fatigue level is done by installing a heart rate sensor and blood oxygen saturation (SpO2) on the driver's wrist. The measurement results are displayed on an OLED screen that contains the condition of the heart rate, oxygen saturation (SpO2) and the level of fatigue. If the fatigue level is at a high level then there will be a warning. Based on the results of trials that have been carried out, the average heart rate measurement error is 1.08% and the oxygen saturation in the blood (SpO2) is 0.81%.
The Legal and Organizational Aspects of Crisis Management in the Single European Sky

Field: Social Sciences (Social Sciences)

Crisis situations in civil aviation pose a serious threat to the safe operation of aviation stakeholders (airports, airlines, air navigation service providers) as well as to passengers using air transport. Therefore, there is a need for an aviation crisis management system that identifies threats, assesses the risk of their occurrence and takes preventive action. The purpose of this paper is to present the determinants of air traffic crisis management in the European Air Traffic Management Network (EATMN). This paper analyses the evolution of this process from the perspective of the EU Single European Sky (SES) legislation. The author also presents lessons learned from the crisis situation that have occurred in European airspace over the last two decades and emphasizes the role of the Network Manager (NM) in resolving them. This article has been developed using a combination of research on EU aviation legislation and background documents and the case study method.
Histopathologic and Ultrastructural Study of Tumors Induced by Murine Sarcoma Virus (MSV).

Field: Medicine (Health Sciences)

Various growth phases of Moloney murine sarcoma virus (M-MSV) induced tumors in suckling and young adult BALB/c mice have been studied by light and electron microscopy. In the early phase (3-6 days following M-MSV), observations at the injection site of the thigh muscles consisted of endo- and perimysial edema, «activated» muscle satellite cells, endothelial cells and fibroblasts, scattered type C virus particles within the muscle fibers, muscle fibers and endomysial cells undergoing necrosis and macrophage and granulocyte infiltration. During the overt tumor phase (6-12 days following M-MSV), observation of neoplastic tissue disclosed proliferation of several cell types (endothelial, periosteal, fibroblasts, etc.), poorly differentiated myoblasts along with atypical rhabdo-myoblast-like cells and sarcolytes, type C virus budding from muscle fiber and myoblast plasma membrane, and intense degenerative and regenerative changes in the muscle fibers together with more profuse granulocyte infiltration. The regressive phase (13-21 days following M-MSV) presented reduced cellularity of the neoplastic tissue, a decrease in blast cells, diminishing granulocyte infiltration with contemporaneous appearance of prominent lymphocyte foci and gradual disappearance of virus particles. Although many cell types of mesenchymal origin proliferate following M-MSV infection, the above morphological findings indicate that striated muscle is a preferential site for virus replication and transformation. Furthermore, the peculiar virus cell relationships leading to cell lysis and continuous recruitment of newly infected cells have been widely documented. In the light of these findings it is suggested that, besides the host immune control of virus spread and tumor cell multiplication, the non clonal growth pattern of M-MSV induced tumors is a crucial factor in determining the spontaneous regression which occurs with high frequency in this experimental system.
Steady-state H+/O stoichiometry of liver mitochondria

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

We have measured the H+/O stoichiometry of rat liver mitochondria respiring in a steady-state, using a novel method. This involves measuring the initial rate of H+ back-flow into mitochondria after respiratory inhibition, with the assumption that this is equal to the steady-state H+-ejection rate. Division by the steady-state O2-consumption rate yields the H+/O ratio. The H+/O values obtained were: 8.3 +/- 1.0 (mean +/- S.E.M.) for 3-hydroxybutyrate: 8.2 +/- 0.7 for glutamate plus malate; 6.0 +/- 0.2 for succinate; 4.1 +/- 0.3 for ascorbate/tetramethylphenylenediamine and 3.0 +/- 0.1 for ascorbate/ferrocyanide. These values correspond to H+/O stoichiometries for electron flow to oxygen from NAD+-linked substrates, succinate and cytochrome c of 8, 6 and 2 (charge/O ratio = 4) respectively.