jimnoneill/paper-to-field-training huggingface dataset:
Early Surgical Management of Medical Tourism Complications Improves Patient Outcomes

Field: Medicine (Health Sciences)

Background: Complications from medical tourism can be significant, requiring aggressive treatment at initial presentation. This study evaluates the effect of early surgical versus conservative management on readmission rates and costs. Methods: A single-center retrospective review was conducted from May of 2013 to May of 2017 of patients presenting with soft-tissue infections after cosmetic surgery performed abroad. Patients were categorized into two groups based on their management at initial presentation as either conservative or surgical. Demographic information, the procedures performed abroad, and the severity of infection were included. The authors’ primary outcome was the incidence of readmission in the two groups. International Classification of Diseases, Ninth Revision ; International Classification of Diseases, Tenth Revision ; and CPT codes were used for direct-billed cost analysis. Results: Fifty-three patients (one man and 52 women) presented with complications after procedures performed abroad, of which 37 were soft-tissue infections. Twenty-four patients with soft-tissue infections at initial presentation were managed conservatively, and 13 patients were treated surgically. The two groups were similar in patient demographics and type of procedure performed abroad. Patients who were managed conservatively at initial presentation had a higher rate of readmission despite having lower severity of infections (OR, 4.7; p = 0.037). A significantly lower total cost of treatment was shown with early surgical management of these complications ( p = 0.003). Conclusions: Conservative management of complications from medical tourism has resulted in a high incidence of failure, leading to readmission and increased costs. This can contribute to poor outcomes in patients that are already having complications from cosmetic surgery. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.
Prevalence of dental flourosis in children 5 to 9 years age from Pedro Apostol School, with exclusive water access from el Chocho brook

Field: Dentistry (Health Sciences)

SUMMARYObjective: To determine the prevalenceof fluorosis in children from 5-9 yearsof age, who have lived since birth in thecorregimiento de Montebello (Cali), andstudying in the Institución Educativa SanPedro Apóstol.Materials and methods: Cross-sectionalstudy with a sample of 60 school children.It was divided into three phases: Phase I:Measurement of minerals from the waterfountain at school. Phase II: Data Collectionon: risk factors and oral hygiene,through a survey of 27 questions. PhaseIII: Clinical examination to identify thepresence of fluorosis using the TFI index.Results: The average concentration offluoride in water was 1.0202 ppm. Theprevalence of fluorosis was 78.4%.Conclusion: The study population has ahigh prevalence of dental fluorosis.Key words: Fluoride, dental fluorosis,epidemiology, oral health.
Arthrogryposis multiplex congenita - a rare congenital stiff joints syndrome

Field: Medicine (Health Sciences)

Introduction: Arthrogryposis multiplex congenita is not a disease but a term describing multiple congenital contractures. Etiological factors include neurological and primary myogenic diseases. This rare syndrome is present at birth and is characterized by reduced mobility of many joints. The contractures involve two or more joints with ankylosis. The accompanying musculature is hypoplastic, but multiple pterygia are also present. Arthrogryposis multiplex congenita is a heterogeneous group of disorders with the incidence rate of 6.2/100000 liveborn infants. The true incidence cannot be established, because many cases result in spontaneous miscarriages or stillbirth. More than 90% of cases are associated with birth defects. The cause of this syndrome is unknown. Many forms are not hereditary, though there are hereditary forms as well. Case report. This paper presents a case with arthrogryposis multiplex congenita. The pregnancy was not controlled regularly. During the pregnancy, oligohydramnion was detected. Due to contractures, labor ended is cesarean section. The child was born in the 34th week of gestation. Flexion and extension joint contractures were observed. Active and passive mobility of the afflicted joints was reduced. There was a limited motor function in the shoulder, elbow and wrist joints with a slight internal rotation of the shoulder joint and lower arm joints during pronation. The hips were subluxated; the feet were in equinovarus position and the fingers in ulnar deviation with partial syndactyly of the 4th and 5th fingers on the left hand. The infant had abnormal dermatoglyphics. The neck was short, and the 2nd and 3rd cervical vertebrae were fused. There was also a slight left-sided thoracic scoliosis. Trismus was present due to the existing ankylosis of the temporomandibular joint. The karyotype was normal. The serum creatinine phosphokinase was slightly elevated. The electromyographic picture indicate non-specific signs of myopathy. Discussion and conclusion. This is a case report of a "stiff joint syndrome". Due to the fact that data from the family history were unavailable, we could not establish the type of syndrome. However, heredity, growth and development at later age, as well as IQ, might significantly help in definite differentiation of this syndrome. In pregnancy, oligohydramnion should indicate more detailed ultrasonographic examination, as ankylosed joints can be detected in utero. .
The Effects of Stress Perception and Social Support on Subjective Well-being According to the Optimism Levels of Pre-service Early Childhood Teachers

Field: Psychology (Social Sciences)

The purpose of this study was to analyze the effects of stress perception and social support on subjective well-being according to differing levels of optimism. The participants in this study were 230 pre-service early childhood teachers, majoring in early childhood education at two universities located in Daegu, Gyeongbuk province. The results of this study could be summarized as follows. First, pre-service early childhood teachers were shown to be more optimistic, be more satisfied with life, and had higher positive emotion rates than average. They also showed lower stress perception and negative emotion rates than average. Second, the highly optimistic group showed higher levels than the less optimistic group in terms of both satisfaction with life and positive emotions. Third, the stress perception in both the highly optimistic group and the less optimistic group had an impact on their satisfaction with life, positive emotions, and negative emotions. The degree of peer support perceived by the highly optimistic group showed an impact on satisfaction with life and negative emotions, whereas the degree of parental support perceived by the less optimistic group showed an impact on their levels of satisfaction with life.
Cytoskeletal Functions During Drosophila Oogenesis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Organismal morphogenesis is driven by a complex series of developmentally coordinated changes in cell shape, size, and number. These changes in cell morphology are in turn dependent on alterations in basic cytoarchitecture. Elucidating the mechanisms of development thus requires an understanding of the cytoskeletal elements that organize the cytoplasm of differentiating cells. Drosophila oogenesis has emerged as a versatile system for the study of cytoskeletal function during development. A series of highly coordinated changes in cytoskeletal organization are required to produce a mature Drosophila oocyte, and these cytoskeletal transformations are amenable to a variety of experimental approaches. Genetic, molecular, and cytological studies have shed light on the specific functions of the cytoskeleton during oogenesis. The results of these studies are reviewed here, and their mechanistic implications are considered.
A fuzzy scheduling controller for a computer disk file track-following servo

Field: Engineering (Physical Sciences)

A fuzzy scheduling capability is superimposed on a computer disk drive track-following servocontroller to adjust for the plant variation as the actuator is locked onto different tracks on the disk. The fuzzy algorithm is found to best represent the complex relationship among the controllers for various tracks. Models of a Zentek 3100 disk drive actuator as it locks on a number of different tracks are experimentally identified to be the reference points. H/sub infinity / design technique is employed to obtain a robust optimal controller for each reference point. The actual controller for the disk drive actuator is calculated using fuzzy interpolation. It is shown that with the controller scheduling action, the closed-loop performance is improved for the actuator at every track position. Error can be kept at a lower level than is the case when only a single controller is used.< >
High Breakdown Strength and Energy Storage Density in Aligned SrTiO3@SiO2 Core–Shell Platelets Incorporated Polymer Composites

Field: Materials Science (Physical Sciences)

Dielectric nanocomposites with high energy storage density (Ue) have a strong attraction to high-pulse film energy-storage capacitors. Nevertheless, low breakdown strengths (Eb) and electric displacement difference (Dmax-Drem) values of nanocomposites with incorporating the randomly distributed high dielectric constant additions, give rise to low Ue, thereby hindering the development of energy-storage capacitors. In this study, we report on newly designed SrTiO3@SiO2 platelets/PVDF textured composites with excellent capacitive energy storage performance. SrTiO3@SiO2 platelets are well oriented in the PVDF when perpendicular to the electric field with the assistance of shear force in the flow drawing process to establish microscopic barriers in an inorganic–polymer composite that is able to substantially improve the Eb of composites and enhance the Ue accordingly. Finite element simulation demonstrates that the introduction of the highly insulating SiO2 coating onto the SrTiO3 platelets effectively alleviates the interface dielectric mismatch between filler and PVDF matrix, resulting in a reduction in the interface electric field distortion. The obtained composite film with optimized paraelectric SrTiO3@SiO2 platelets (1 vol%) exhibited a maximum Dmax-Drem value of 9.14 μC cm−2 and a maximum Ue value of 14.4 J cm−3 at enhanced Eb of 402 MV m−1, which are significantly superior to neat PVDF and existing dielectric nanocomposites.
Rusbult’s Investment Model Validity for Explaining Remaining in Abusive Relationship for Sample of Jordanian Abused Women

Field: Psychology (Social Sciences)

This study aimed to explore Caryl Rusbult’s model validity for explaining women remaining in an abusive relationship for available sample of 35 Jordanian abused women and living in the abusive relationship who are contacting the women and child health center in Prince Faisal Hospital. The World Health Organization (WHO) Domestic Violence (DV) scale and Rusbult’s Investment Model Scale (IMS) were used. The results revealed low levels of Marriage Satisfaction (MS) and Quality of Alternatives (QA). Moderate levels of Relationship Investment size (RI) and Marriage Commitment (MC) were found. The result also indicated that there were not significant statistical differences between the IMS scale dimensions (MS, RI and QA) and women's commitment in relationship variable. The results indicated the validity of the investment model to be applied to Jordanian culture.
Diagnostic Value of Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Children with Urinary Tract Infections

Field: Medicine (Health Sciences)

Abstract Objective The aim of the present study was to evaluate the diagnostic value of soluble triggering receptor on myeloid cells-1 as a novel marker for diagnosis of childhood urinary tract infections (UTI). Methods This study enrolled 30 pediatric patients diagnosed with acute febrile UTIs; 30 healthy children were included as the control group. The blood samples from the patients and healthy controls were collected for a soluble triggering receptor on myeloid cells-1 (sTREM-1) test. Results The study group was composed of 9 males and 21 females, and the mean age of the study population was 6.6 ± 3.2 (range = 1–14) years. sTREM-1 levels were significantly higher in UTI patients than in the controls (592 ± 323 vs. 490 ± 299 pg/mL, p = 0.04). The receiver operating curve analysis revealed a cut-off value of soluble triggering receptor expressed on myeloid cells-1 of 514 ng/mL (area under the curve = 0.562). When the cut-off value was taken 514 pg/mL, soluble triggering receptor expressed on myeloid cells-1 had a sensitivity of 57% and a specificity of 50% for the diagnosis of UTI. Conclusion The present study revealed that plasma sTREM-1 level may be elevated in UTI and may therefore serve as a useful predictive tool for the diagnosis of UTI.
A 10-Gb/s CMOS clock and data recovery circuit

Field: Engineering (Physical Sciences)

A 10-Gb/s phase-locked clock and data recovery circuit incorporates a 5-GHz interpolating voltage-controlled oscillator and a half-rate phase detector. The phase detector provides a linear characteristic while retiming and demultiplexing the data with no systematic phase offset. Fabricated in a 0.18-/spl mu/m CMOS technology, the circuit exhibits an rms jitter of 6.6 ps in the recovered clock with random data input of length 2/sup 23/-1. The power dissipation is 99 mW from a 2.6-V supply.
MANAGING INDOXACARB POISONING - A RARE PRESENTATION

Field: Medicine (Health Sciences)

Indoxacarb is a non-organophosphorous compound. It is a newer insecticide used rarely compared to the more common organophosphates by farmers. Hence less information is available on its toxic effects in humans. Timely diagnosis and management in ER can avoid unnecessary mechanical ventilation and other complications. There are few case reports in the literature about indoxacarb poisoning, most of them requiring mechanical ventilation. This is a case of indoxacarb poisoning resulting in methemoglobinemia and seizures timely managed with methylene blue and oxygen support without any need for mechanical ventilatory support.
Honey Protein as Internal Standard for Stable Carbon Isotope Ratio Detection of Adulteration of Honey

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Using the difference in stable carbon isotope ratio between a honey and its protein fraction permits objective evaluation of possible adulteration of honey with small amounts (7-20%) as well as larger amounts of corn or cane sugar. The present uncertainty in interpretation of results from pure honeys with 5,3C values outside the generally accepted limits for pure honey of —27.5%o to —23.5%o is eliminated; likewise TLC testing to resolve questionable samples with 5n C values between —23.5 and —21.5%o is not needed. Fifty certified samples of pure honey were used to establish criteria for purity, and 38 other samples with δ13C values in the “questionable” or “adulterated” range for the AOAC official method were tested. A difference of 1.0%o or more between honey and protein fractions is proposed to indicate adulteration.
The effect of dynamic active-inactive agents on spreading phenomena

Field: Computer Science (Physical Sciences)

In this work a novel model of spreading processes is presented.The model is an upgrade of a previously introduced model of information spreading [1].Here we take into account that agents of the system are not always active during the spreading and information can flow only through those that are currently active.In order to suit our work to other findings related to spreading phenomena we describe our model using the classical terminology of disease spreading.Namely our model can be viewed as an SRS/SIRI model of disease spreading [4].Based on this model we carried out computer simulations showing that the activity of agents highly affect the process.The results of the work can be used to qualitatively predict what would be the effect if the activity of agents change in a social system e.g. in a social network.
Data from SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<div>Abstract<p>The sigma 1 receptor (Sig1R) is a stress-activated chaperone that regulates ion channels and is associated with pathologic conditions, such as stroke, neurodegenerative diseases, and addiction. Aberrant expression levels of ion channels and Sig1R have been detected in tumors and cancer cells, such as myeloid leukemia and colorectal cancer, but the link between ion channel regulation and Sig1R overexpression during malignancy has not been established. In this study, we found that Sig1R dynamically controls the membrane expression of the human voltage-dependent K<sup>+</sup> channel human ether-à-go-go-related gene (hERG) in myeloid leukemia and colorectal cancer cell lines. Sig1R promoted the formation of hERG/β1-integrin signaling complexes upon extracellular matrix stimulation, triggering the activation of the PI3K/AKT pathway. Consequently, the presence of Sig1R in cancer cells increased motility and VEGF secretion. <i>In vivo</i>, Sig1R expression enhanced the aggressiveness of tumor cells by potentiating invasion and angiogenesis, leading to poor survival. Collectively, our findings highlight a novel function for Sig1R in mediating cross-talk between cancer cells and their microenvironment, thus driving oncogenesis by shaping cellular electrical activity in response to extracellular signals. Given the involvement of ion channels in promoting several hallmarks of cancer, our study also offers a potential strategy to therapeutically target ion channel function through Sig1R inhibition. <i>Cancer Res; 76(3); 607–18. ©2015 AACR</i>.</p></div>
Finding the missing millions: lessons from 10 active case finding interventions in high tuberculosis burden countries

Field: Health Professions (Health Sciences)

### Summary box

In 2019, 10.0 million people developed tuberculosis (TB) yet 2.9 million were not notified to National TB programmes (NTPs).1 This is largely due to limited accessibility to healthcare services, underdeveloped health reporting systems, insufficient human resources and poor linkages between private providers and national authorities.2 There are various global initiatives to address this challenge, including the Find.Treat.All #EndTB initiative and the End TB strategy which aims to reduce TB incidence by 90% between 2015 and 2035.3

To support innovative programmes, approaches and technologies aiming to increase the number of people detected with TB in low-and-middle income countries (LMICs), the TB REACH initiative was launched in 2010. It is led by the Stop TB Partnership …
Peer review of the pesticide risk assessment of the active substance indoxacarb

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The conclusions of EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, France, and co-rapporteur Member State, Spain, for the pesticide active substance indoxacarb are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of indoxacarb as an insecticide on maize, sweet corn and lettuce. The reliable endpoints, appropriate for use in regulatory risk assessment, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.
Gastro-Resistant Microparticles Containing Sodium Pantoprazole: Stability Studies and In Vivo Anti-Ulcer Activity

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The aim of the present work was to verify the in vivo capacity of pantoprazole-loaded microparticles to protect the gastric mucosa against ulcer formation and to evaluate their stability under accelerated conditions.Pantoprazoleloaded microparticles were prepared by spray-drying in pilot scale, using Eudragit ® S100 as polymer.Transparent glass vials containing drug-loaded microparticles were stored for 6 months at 40°C and 75% RH.Photostability was tested under UVA light.Ulcers were induced by the oral administration of absolute ethanol to rats.Sodium bicarbonate solution, pantoprazole solution and drug-loaded microparticles were tested.Regarding the drug content during the accelerate stability study, samples showed complete encapsulation efficiency and were considered stable.The microencapsulation of pantoprazole reduced its photodegradation.The in vivo evaluation showed that the microparticles presented ulcer index lower than the solutions.Enteric microparticles had acceptable stability under accelerated conditions and were efficient in protecting the stomach against ulceration caused by ethanol.
Abstract 2038: Antibody Drug Conjugates Treatment Response Score (ADC TRS) for predicting ADC treatment response

Field: Medicine (Health Sciences)

Abstract Background: Predictive biomarkers for multiple ADCs/tumor types (beyond 3+ HER2 IHC) are lacking. We previously reported the discovery of ADC TRS—an algorithm combining individual ADC target expression, proliferation, and adhesion by RNAseq to predict ADC clinical benefit across tumor types/targets—and association with OS after ADC treatment (Abstract 3140, ASCO 2024). Here we evaluated the final ADC TRS biomarker (ADC-specific; tuned on &gt;100 tumor type/ADC RRs) by a qRT-PCR based clinical trial assay (CTA) for predicting ADC clinical benefit. Methods: Adults in the Kaiser Permanente Northern California (KPNC) system with advanced bladder or breast cancer in an observational trial (NCT03061305) who were treated with an approved ADC (enfortumab vedotin [EV], sacituzumab govitecan [SG] or trastuzumab deruxtecan [T-DXd]; first dose by Apr. 21, 2023) with valid CTA TRS results from FFPE tissue (collected prior to 1st ADC treatment) were eligible; patients with prior trastuzumab or hormonal (between tissue collection/ ADC start) treatment were excluded. KPNC oncologists (blinded to ADC TRS status) determined best response to therapy from chart review. ADC TRS status (+ vs. -) / response data were merged by the KPNC statistician and analyzed per a prespecified plan. Results: A total of 117 KPNC patients with advanced bladder (n=58 [50%]) or breast (n=59 [50%]) cancer treated with an approved ADC (n= 56 [48%], 47 [40%], and 14 [12%] EV, SG, and T-DXd, respectively) were evaluable for TRS and RR. As shown in the Table, TRS+ status was associated with significantly higher RR and longer PFS and OS for approved ADC treatment; results were generally similar across ADCs and tumor type. Conclusions: By a qRT-PCR based CTA, TRS+ status was associated with improved RR, PFS and OS for approved ADCs in an observational cohort of patients with advanced bladder or breast cancer. Prospective validation for approved and/or investigational ADCs is warranted. Citation Format: Sachdev P. Thomas, Laurel A. Habel, Jennifer M. Suga, Ninah Achacoso, Joshua R. Nugent, Chen Jiang, Elaine Chung, Stephanie Bush, Michael D. Nitchie, Katarina M. Robinson, Jasie Inman, Ryan White, Komal Plouffe, Daniel R. Rhodes, Scott A. Tomlins, Bryan Johnson. Antibody Drug Conjugates Treatment Response Score (ADC TRS) for predicting ADC treatment response [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 2038.