jimnoneill/paper-to-field-training huggingface dataset:
RETRACTED: MicroRNA-223-3p Regulates Ovarian Cancer Cell Proliferation and Invasion by Targeting SOX11 Expression

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

MicroRNAs (miRNAs) often display different expression in many cancers and other diseases in current research studies. miR-223 expression is upregulated in rheumatoid arthritis. Also, miR-223 expression has been demonstrated to be highly expressed in pancreatic cancer and gastric cancer in comparison with normal tissue. However, whether miR-223 displays different expression in ovarian cancer and what its underlying functions are in ovarian cancer have remained unclear. In this study, we demonstrated that miR-223-3p was upregulated in ovarian cancer tissue. Next, we explored the functional role of miR-223-3p in ovarian cancer using SKOV3 and OVCAR3 cell lines. Our results suggested that miR-223-3p mimic promoted ovarian cancer cell proliferation, migration, and invasion in vitro. However, miR-223-3p inhibitor displayed the opposite effects. In addition, we demonstrated that miR-223-3p mimic promoted tumor growth in vivo. Furthermore, we found SOX11 (sex determining region Y-box 11) was inversely expressed with miR-223-3p in ovarian cancer (OC) cell lines and tissue specimens. miR-223-3p mimic decreased SOX11 expression. Overexpressing SOX11 inhibited ovarian cancer cell proliferation and invasion, which indicated that miR-223-3p regulated OC cell proliferation and invasion through targeting SOX11 expression. In conclusion, the findings of the present study demonstrated that miR-223-3p could be a potential therapeutic for ovarian cancer.
Cross-cultural validation of the Spanish version of the mini cambridge-exeter repetitive thought scale (Mini-CERTS) in two Spanish-speaking populations

Field: Psychology (Social Sciences)

The Mini Cambridge-Exeter Repetitive Thoughts Scale (Mini-CERTS) captures constructive and unconstructive aspects of repetitive thinking, but there is a need to revise and improve it given its novelty. For this reason, we present a validation and factor analysis of the Spanish version of the Mini-CERTS. Given that it is important to take cultural issues into account in instrument adaptation, we also assess its measurement invariance across Spanish ( N = 430) and Peruvian ( N = 394) populations. After deleting conflictive items, a 9-items version of the Mini-CERTS showed a two-factor model distinguishing constructive and unconstructive repetitive thinking, although this solution was not invariant across groups. Results also showed that the unconstructive factor was positively associated with anxiety, depression and stress measures. Despite its acceptable internal consistency, the absence of measurement invariance across groups does not recommend its use in cross-group comparisons in these populations. Cultural issues that could explain this result are discussed. Our findings highlight the importance of performing cross-cultural adaptations of assessment instruments even with the same language.
Proliferation of natural suppressor cells in long-term cultures of spleen cells from normal adult mice

Field: Immunology and Microbiology (Life Sciences)

Abstract Natural suppressor cells were induced by culturing spleen cells from normal adult mice for 2 to 3 wk. The suppressor cells were large in size, nonadherent and nonspecifically suppressed the plaque-forming cells response of fresh spleen cells to SRBC in vitro. The suppressive activity of the cells was not affected by treatment with indomethacin or anti-Thy-1, anti-Ig, anti-Ia, or anti-asialoGM1 plus complement. Phenotype analysis by FACS showed that Thy-1, L3T4, Ly-2, CD3-epsilon, TCR-alpha beta, Ig, B220, Ia, and asialoGM1 Ag were all absent in the suppressor cells, although they were wheat germ agglutinin receptor positive. The suppressor cells did not demonstrate cytotoxicity against either YAC-1 or P-815 cells. Enriched large cell populations from fresh normal spleens expressed the same phenotypes and also exhibited the suppressive activity. These findings suggest that a minor population of natural suppressor cells exist in the normal adult mouse spleen and they proliferate during the in vitro culture of spleen cells.
[Ocular infections in immunodepressed patients].

Field: Medicine (Health Sciences)

Two kinds of immunosuppression must be distinguished: malignant diseases on one hand, and acquired immunodeficiency syndrome on the other hand. Ocular infections can involve any part of the eye and they can lead to blindness. They usually attest of a systemic infection. Their treatment consist of an induction course to provide complete healing of the lesions, immediately followed by a maintenance course to prevent relapses. Retinitis are the most common posterior involvement, especially the retinitis due to cytomegalovirus and Toxoplasma gondii. Zoster ophtalmicus is the most common anterior involvement. Mucormycosis is rare but very severe. A closed collaboration between ophtalmologists and internists is mandatory to provide the most appropriate management of these infections.
The African national congress and its critics: ‘predatory liberalism’, black empowerment and intra-alliance tensions in post-apartheid South Africa

Field: Social Sciences (Social Sciences)

Post-apartheid South Africa is characterized by centralized, neo-liberal policymaking that perpetuates, and in some cases exaggerates, socio-economic inequalities inherited from the apartheid era. The African National Congress (ANC) leadership’s alignment with powerful international and domestic market actors produces tensions within the Tripartite Alliance and between government and civil society. Consequently, several characteristics of ‘predatory liberalism’ are evident in contemporary South Africa: neo-liberal restructuring of the economy is combined with an increasing willingness by government to assert its authority, to marginalize and delegitimize those critical of its abandonment of inclusive governance. A new form of oligarch power, combining entrenched economic interests with those of a new ‘black bourgeoisie’ promoted by narrowly implemented Black Economic Empowerment policies, diminishes prospects for broad-based socio-economic transformation. Because the new policy environment is failing to resolve tensions between global market demands for increasing market liberalization and domestic popular demands for poverty-alleviation and socio-economic transformation, the ANC leadership is forced increasingly to confront ‘ultra-leftists’ who are challenging its credentials as defender of the National Democratic Revolution which was the cornerstone in the anti-apartheid struggle.
PENGEMBANGAN INSTRUMEN BAKU KECERDASAN JAMAK ANAK USIA DINI

Field: Psychology (Social Sciences)

Abstract: This reasearch was done in the form of research and development. The reason underlied the selection of the reasearch method was because the purpose of the reseacrh was to develop a valid and realiable instrument which can be used to measure the multiple-intellegences of the 4-5 years old childen. The multiple-intelligences measured were consisted of eigth dimensions, there were: verbal/linguistic intelligence, logical mathematical intelligence, visual spatial intelligence, intrapersonal intelligence, interpersonal intelligence, bodily/kinesthetic intellgence, music/rythmic intelligence and naturalist intelligence. Based on the need in researching and developing, therefore, the study was conducted in two faces, as folowed : (1) the first face was literature research aiming to analyzed and synthesis concepts, principles, and theories. The result of the literature study was used formulte the construct of multiple intelligences, especially for the 4-5 years old children; (2) the second face was to define and to develop the valid and reliable multiple intelligences instrument for the 4-5 years old children. Abstrak: Penelitian ini dilakukan dengan metode research and Development. Alasan pemilihan metode tersebut karena tujuan penelitian ini adalah mengembangkan validitas dan reliabilitas suatu instrumen yang bisa digunakan untuk mengukur kecerdasan majemuk anak usia 4-5 tahun. Kecerdasan majemuk dikur dengan delapan dimensi, yaitu: kecerdasan bahasa/verbal, kecerdasan logika matematika, kecerdasan visual, kecerdasan intrapersonal, kecerdasan interpersonal, kecerdasan gerak/kinestetik, kecerdasan musik, dan kecerdasan natural. Berdasarkan penelitian dan pengembangan, oleh karena itu, penelitian ini dilaksanakan dalam dua tahap, yaitu: (1) tahap pertama adalah penelitian literatur yang bertujuan untuk menganalisis dan mensintesis konsep, prinsip, dan teori. Hasil dari penelitian literatur digunakannnya rumus untuk mengkonstruksi kecerdasan majemuk. Khususnya anak usia 4-5 tahum, (2) tahap kedua yaitu mendefinisikan dan mengembangkan validitas dan reliabiltas instrumen kecerdasan majemuk untuk anak usia 4-5 tahun. Kata Kunci: penelitian dan pengembangan, kecerdasan majemuk, instrumen validitas dan reliabilitas, anak usia 4-5 tahun, penelitian literatur, mendefinisikan dan mengembangkan
Sarcoidosis and Testicular Neoplasm: An Unusual Association

Field: Medicine (Health Sciences)

A case of sarcoidosis of the mediastinal lymph nodes with concomitant teratoembryonal carcinoma of the testis is presented. It is important to differentiate these entities from mediastinal metastases of testicular tumors and testicular sarcoidosis, respectively. We favor mediastinal biopsy in appropriate cases, in addition to testicular exploration.
Direct demonstration of structural changes in soluble, monomeric Ca2+-ATPase associated with Ca2+ release during the transport cycle.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The time courses of changes in protein conformation and Ca2+ binding in the phosphorylated state of membrane-bound and soluble monomeric Ca2+-ATPase from sarcoplasmic reticulum have been examined at pH 8.0, 2 degrees C. The transition from ADP-sensitive to ADP-insensitive phosphoenzyme occurs in the soluble monomer as well as in membranous Ca2+-ATPase and is accompanied by an increase in fluorescence from 2',3'-O-(2,4,6-trinitrocyclohexyldienylidine)-adenosine diphosphate bound to the catalytic site and change in tryptic cleavage pattern. A decrease of Ca2+ affinity occurs simultaneously with the fluorescence rise, suggesting a single-step mechanism for energy transfer between the catalytic site and the Ca2+ transport sites. This is in accordance with the tryptic degradation pattern that suggests proximity between the phosphorylation site and Ca2+ transport sites on the peptide. The structural changes occurring in the soluble monomeric Ca2+-ATPase show that a single polypeptide chain is the functional unit in energy transduction.
The Molecular Basis of Proteinuria

Field: Medicine (Health Sciences)

HIPPOCRATES observed more than 2,000 years ago that "bubbles on the surface of the urine are a sign of diseases of the kidney." One might speak today of protein molecules altering surface tension and thereby producing foam, but the bedside sign described so long ago remains valid. The stately pace of medicine saw two millenia go by uneventfully until Dekkers demonstrated proteinuria in 1695 by boiling acidified urine and producing a precipitate. A century later, in 1798 Cruickshank showed that "the coagulable part of the serum is detected in morbid states of the urine."1Bright,2busy laying the foundation of modern nephrology from 1827 to 1840, noted that patients with massive proteinuria could experience hypoproteinemia. Nineteenth-century workers further developed the concept that the kidney acted as a semipermeable membrane that, in health, prevented the loss of plasma protein in the urine. It was assumed that an injured kidney
Unbiased analysis of all possible neoepitopes of MC38-FABF tumor reveals a new universe of cancer neoepitopes with unexpected properties

Field: Medicine (Health Sciences)

Abstract Cancer neoepitopes are the only truly tumor-specific antigens and therefore, the most suitable as cancer vaccines. Current methods to predict neoepitopes, based on studies of viral epitopes, emphasize high affinity MHC-peptide interactions. Increasing evidence in human and murine models indicates that the present neoepitope prediction methods are mostly inaccurate in predicting true MHC I-restricted cancer neoepitopes. Here, in a completely unbiased approach, all possible neoepitopes in a mouse tumor model were tested for their ability to mediate tumor rejection and also CD8+ T cell responses. These studies show that the true tumor rejecting neoepitopes have different properties from those of viral epitopes. Further, CD8+ T cell responses elicited by these neoepitopes possess a more plastic chromatin phenotype with stem-like properties that is known to be associated with anti-viral and anti-tumor immune responses. Such cancer neoepitopes can be exploited for generation of personalized cancer vaccines.
Verification of gait control based on reaction null-space for ground-gripping robot in microgravity

Field: Engineering (Physical Sciences)

The surface of a minor body in space features a harsh terrain and microgravity. To explore such surfaces in detail, a robot with an appropriate moving mechanism is required. To this end, we proposed a robot that moves by gripping the surface like a rock climber. We focus on the robot's gait, where the motion of the idling arm generates the reaction force that acts on the gripper of the supporting arm. The reaction force needs to be controlled to maintain a grip without slipping. Therefore, we formulate a simultaneous control law that combines the tip position control of the idling arm with reactionless control by utilizing the reaction null-space. Moreover, the validity of the control law was confirmed by an experiment involving an air floating system under microgravity. Furthermore, a planar simulation clarified that the robot can move continuously on an irregular terrain.
Practitioner Case Study

Field: Computer Science (Physical Sciences)

This interview-based case study describes current portal project practices based on a diverse set of projects, including B2B, B2C, B2E, E2E and mobile. Since 2000 portals have increased their functionality, and widespread availability of portal software has encouraged organisations to install and experiment with them. Portals are adding value by drawing applications together, particularly through search, and assembling existing tools for a user in a way that enhances their value. Operational challenges include support and security. Success has depended on beginning with support and security frameworks based on similar industry experience. Performance has been the key project success factor, and project sponsors are beginning to understand non-functional requirements: portability, scalability, availability, reliability and security. SOA principles are only partially applied, due to investment in existing systems. A recent trend is Microsoft SharePoint’s rapid market growth through ease of implementation.
Antineutrophil antibody: a test for autoimmune primary sclerosing cholangitis in childhood?

Field: Medicine (Health Sciences)

The detection of an antineutrophil antibody which is highly sensitive and specific for adult primary sclerosing cholangitis using indirect immunoalkaline phosphatase has been previously described. In this study, the diagnostic potential of this method in childhood primary sclerosing cholangitis is described. A range of 72 blinded children's sera (36 boys), aged six months to 21 years (10 primary sclerosing cholangitis, eight autoimmune chronic active hepatitis, 10 alpha-1 antitrypsin deficiency, 12 extrahepatic bile duct atresia, 11 ulcerative colitis and 21 normal subjects) was assayed. Eight of the 10 primary sclerosing cholangitis patients were correctly identified. Three patients with chronic active hepatitis also showed the characteristic primary sclerosing cholangitis pattern of staining. No ulcerative colitis patients or any other patients showed this pattern of staining. All normal subjects were negative. As in adult primary sclerosing cholangitis, there is a specific antineutrophil antibody in childhood primary sclerosing cholangitis and this provides further evidence towards an autoimmune aetiology of this condition. The test may have diagnostic potential.
Target Tracking based on Kernel Correlative Filters and SIFT features - A Self-Adaptive Scale Algorithm

Field: Computer Science (Physical Sciences)

In order to solve the problem of KCF tracking target loss which is caused by target occlusion and target scale change, This paper proposed an anti-occlusion target tracking algorithm based on kcf and sift features. The scale pyramid is used to estimate the scale of the target, Then realized the adaptive target size of the tracking. When the target is occluded, the sift feature is extracted from the target in the current frame box, next tracking frame will generate template features. The next frame of video image and matching the feature template, frame matching and template feature target for target tracking. Our algorithm is tested on the TB datasets. The experimental results show that our tracking frame can adapt to the size of the target, and when the target is occluded, It stills be able to find new targets and accurate tracking.
Original Contribution BEHAVIOUR OF TURKEY BROILERS WITH AND WITHOUT MUSCLE DYSTROPHY UNDER CONDITIONS OF ANIMAL WELFARE OR STRESS

Field: Veterinary (Health Sciences)

The aim of the present study was to produce experimental muscular dystrophy in 40 broiler turkeys under conditions of high animal welfare or stress and to study the behaviour of the broilers under these conditions. Muscular dystrophy was induced via supplementation of 4% fat with peroxide number 5.0 in a balanced but vitamin E deficient starter forage containing selenium (Se) and fed to four groups of broiler turkeys subjected to different conditions. The results indicated clearly that muscle dystrophy in turkey broilers, under stress, exerted a strong effect on the feeding behaviour manifested in reduced frequency of feeding and increased frequency of drinking, as well as on the flocking behaviour, shown by increased frequency of resting and lower frequency of walking. Without muscular dystrophy stress had an insignificant impact on these behaviours.
Lost Hills Navel Orangeworm Area-Wide Project 2006 to 2015: Mating Disruption, Insecticide, and Damage

Field: Agricultural and Biological Sciences (Life Sciences)

Data files and scripts for processing the data in support of the paper "Individual and additive effects of insecticide and mating disruption in integrated management of navel orangeworm in almonds", accepted for publication in insects on 2021-02-17.
Microstructure Dependence of Small Fatigue Crack Growth in Beta Ti-15Mo-5Zr-3Al Alloy

Field: Materials Science (Physical Sciences)

Growth behaviour of small fatigue cracks has been investigated on three materials with different microstructures of a beta Ti-15Mo-5Zr-3Al alloy which were solution treated at 735°C, 850°C and 1000°C, followed by aged at 500°C (STA735, STA850 and STA1000) at a stress ratio of-1 under axial loading in laboratory air. The da/dN-Kmax relationships for STA735 and STA850 were almost the same as the da/dN-ΔK relationships for large cracks, while STA1000 showed initially lower growth rates than large cracks, and then the growth rates rapidly increased and became faster at an intermediate Kmax regime than those of large cracks. After allowing crack closure, STA850 and STA1000 still exhibited enhanced growth rates, which was found to be attributed to the crystallographic nature of small crack growth based on a close examination of the fracture surfaces. The trace of the crack front remained on the fracture surfaces of STA850 and STA1000 represented the transition from the microstructurally small crack to the mechanically small crack, which has occurred at a/d=2.63.9 for STA850 and a/d= 1.62.1 for STA1000, where a and d were the crack depth and the beta grain size, respectively. Of three materials, STA1000 showed the lowest growth resistance of small cracks at intermediate Kmax and ΔKeff regimes. Furthermore, it was found that all the materials of the beta alloy exhibited lower growth rates at low Kmax regime than an annealed Ti-6Al-4V alloy, but the difference disappeared in terms of ΔKeff, indicating that crack closure was responsible for the difference in growth behaviour between both alloys.
Prostate specific membrane antigen- a target for imaging and therapy with radionuclides.

Field: Medicine (Health Sciences)

Prostate cancer continues to represent a major health problem, and yet there is no effective treatment available for advanced metastatic disease. Thus, there is an urgent need for the development of more effective treatment modalities that could improve the outcome. Because prostate specific membrane antigen (PSMA), a transmembrane protein, is expressed by virtually all prostate cancers, and its expression is further increased in poorly differentiated, metastatic, and hormone-refractory carcinomas, it is a very attractive target. Molecules targeting PSMA can be labelled with radionuclides to become both diagnostic and/or therapeutic agents. The use of PSMA binding agents, labelled with diagnostic and therapeutic radio-isotopes, opens up the potential for a new era of personalized management of metastatic prostate cancer.
A comparative assessment of secondary school students' satisfaction with ICT studies: Implications for managing secondary school education for global competitiveness in post COVID-19 era

Field: Social Sciences (Social Sciences)

Technological advancement has ushered Computer studies which is also regarded as Information and Communication Technology (ICT) instruction into educational curriculum. The aim of ICT studies in secondary school system is to equip every student with the prerequisite skills and competence to function effectively in the contemporary society that is characterized by emerging technologies. Therefore, the main objective of this research was to assess students’ satisfaction with ICT instruction in secondary schools in Calabar Metropolis, Cross River State, Nigeria. Three research hypotheses were formulated to give direction to the study. The study sample was 5245 students drawn from the population of Senior Secondary (SS) 2 and Senior Secondary (SS) 3 classes across public and private schools in 2019/2020 academic session. A survey research design was adopted for the study. The instrument for data collection was a questionnaire entitled "Secondary School Students' Satisfaction with Computer Studies Questionnaire (SSSSCSQ)". The data collected were analyzed using population t-test and independent t-test. The major findings indicated that secondary school students' satisfaction with ICT instruction was not significantly differ with respect to school ownership, gender and school location. It was recommended among others that the Government at various levels, Non-Governmental Organizations (NGOs) as well as Parents Teachers Association (PTA) should improve in their efforts towards provision of both hardware and software ICT facilities to sustain blended pedagogy in Post Covid-19 era.