jimnoneill/paper-to-field-training huggingface dataset:
PP07. A PML/POLYCOMB/SLIT AXIS REGULATES MIGRATION OF BOTH NORMAL AND NEOPLASTIC CELLS IN THE CNS

Field: Neuroscience (Life Sciences)

INTRODUCTION: The control of SVZ neural progenitor/stem cells (NPCs) migration through the rostral migratory stream (RMS) is essential for normal neurogenesis and serve as the fundamental basis of production/replacement of neurons in the adult brain. Alterations of these processes can lead to neoplastic transformation and glioblastoma multiformeÂ (GBM). The ability of GBM cells to migrate through the brain parenchyma represents a key factor underlying GBM aggressiveness. GBM cells use the same routes used by neuroblasts/immature neurons and neural stem cells upon injury, such as vessels and myelin tracts, suggesting that GBM migration may lay its roots in essential cellular processes controlling migration of immature neurons/neuroblasts and neural stem cells (1). However, our understanding of mechanisms regulating cell migration/invasion during brain tumourigenesis remains limited. METHODS: We combined in vivo and in vitro approaches, including the use of genetically modified mice, primary HGG tissues/NPCs (in collaboration with S Brandner, UCL, C Jones, ICR, S Pollard, Edinburgh, and others). RESULTS: Here we report that the stem cell factor and RAS effector Promyelocytic Leukaemia protein (PML) (2,3) regulates cell migration through the epigenetic control of Slit axon guidance genes in normal and neoplastic cells in the central nervous system. Loss of PML leads to impaired NSC and neuroblast migration and a smaller olfactory bulb in the adult mouse brain. PML controls cell migration via Polycomb Repressive 2-dependent regulation of the Slit axon guidance genes. AÂ similar epigenetically controlled PML/Slit axis is functional also upon RAS-driven neoplastic transformation of NSCs and in primary GBM cells. PML expression inversely correlates with Slit1 expression and patient prognosis in GBM and is enriched in the mesenchymal subtype, which is characterized by activation of the RAS/MAPK pathway. Finally, PML loss impairs tumor growth in an orthotopic animalÂ model. CONCLUSIONS: Taken together, these findings disclose a novel molecular axis at the root of cell migration during normal neurogenesis and brain tumourigenesis.
Reversibly Reconfigurable Colloidal Plasmonic Nanomaterials

Field: Materials Science (Physical Sciences)

With their unique ability to concentrate and scatter light, plasmonic nanomaterials have been the focus of tremendous synthesis and characterization efforts in the past two decades. Recently, the topic of reversibly reconfigurable plasmonic nanomaterials has become an intensive research area offering the opportunity to reconfigure the optical, mechanical, electronic, and catalytic properties of materials with promising applications in fields ranging from biosensors to nanorobotics and energy. This Perspective discusses the state of the art in the fabrication and application of reversibly reconfigurable colloidal plasmonic nanomaterials based on the actuation of interparticle couplings and explores some promising directions for future research ranging from direction control, two-dimensional materials, and the incorporation of feedback mechanisms for designing robust responses.
Reducing and Balancing Flow Table Entries in Software-Defined Networks

Field: Computer Science (Physical Sciences)

Software-Defined Networking (SDN) allows flexible and efficient management of networks. However, the limited capacity of flow tables in SDN switches hinders the deployment of SDN. In this paper, we propose a novel routing scheme to improve the efficiency of flow tables in SDNs. To efficiently use the routing scheme, we formulate an optimization problem with the objective to maximize the number of flows in the network, constrained by the limited flow table space in SDN switches. The problem is NP-hard, and we propose the K Similar Greedy Tree (KSGT) algorithm to solve it. We evaluate the performance of KSGT against "traditional" SDN solutions with real-world topologies and traffic. The results show that, compared to the existing solutions, KSGT can reduce about 60% of flow entries when processing the same amount of flows, and improve about 25% of the successful installation and forwarding flows under the same flow table space.
Prevention and Detection of Fraud in Village Fund Supervision in Barito Kuala District

Field: Business, Management and Accounting (Social Sciences)

ABSTRACTThe purpose of this study is to map the pattern of the village fund supervision system and detect the possibility of loopholes in the system. So that it can provide recommendations for strategy formulations that are able to prevent fraud in village fund management. This research uses qualitative methods with a case study research strategy. The results showed that there was no fraud found in the three research objects, but the potential for fraud still exists and can change to be fraud due to lack coordination of supervision between related institutions and unsolid whistleblowing system. This paper offers strengthening internal control and whistleblowing system to address issues concerning the village fund supervision system.ABSTRAKTujuan penelitian ini adalah memetakan pola sistem pengawasan dana desa dan mendeteksi kemungkinan adanya celah (loopholes) fraud dari sistem tersebut sehingga dapat memberikan rekomendasi strategi yang mampu mencegah tindakan fraud pada pengelolaan dana desa. Penelitian ini menggunakan metode kualitatif dengan pendekatan studi kasus. Hasil penelitian menunjukkan bahwa tidak ada fraud yang ditemukan pada tiga objek penelitian, tetapi potensi fraud eksis dan bisa mengubah pada kondisi yang yang menyebabkan terjadinya fraud akibat belum optimalnya koordinasi pengawasan antar lembaga dan belum solidnya sistem whistleblowing yang dimplementasikan. Paper ini menawarkan penguatan pengendalian internal dan whistleblowing system yang terintegrasi agar permasalahan sistem pengawasan dana desa bisa diselesaikan dengan baik.
Issues Surrounding Post-Adoption Contact in Foster Adoption: The Perspective of Foster-to-Adopt Families and Child Welfare Workers

Field: Social Sciences (Social Sciences)

Current research on open adoption gives less consideration to issues surrounding post-adoption contact with birth parents for children adopted from care. Yet, it is widely recognized that the profile of the children and their birth parents, as well as the quality of post-adoption contacts, vary considerably depending on the context in which the adoption takes place. This article is based on interviews with 32 child welfare workers and 16 foster-to-adopt families. It focuses specifically on aspects and conditions that should be taken into consideration when determining whether or how contact between the adopted child and the birth family should be maintained. Our results show that there are distinctive challenges and dilemmas for open adoption in situations where the adopted child comes from a maltreating family, under the responsibility of child welfare services.
A PROPOSED SYLLABUS BASED ON LEARNERS’ MULTIPLE INTELLIGENCE PROFILE AT KIDDYCEL NATIONAL PLUS SCHOOL SEMARANG

Field: Arts and Humanities (Social Sciences)

Teaching English to Young Learners is not as easy as teaching adults. Teachers at Kiddycel National Plus School face a problem in teaching the students. The teacher said that some of the learners can do their work better after seeing someone else do it first. Some of them can do their work better through music as the background or humming their
favorite song. The phenomenon above shows that all learners are different in solve their problems in different ways. Learners’ ability to solve their problems is known as an Intelligence. According to Gardner each individual has more than one intelligences. They are linguistic, logicalmathematic, spatial-visual, musical, interpersonal, intrapersonal and natural intelligences. Teachers at Kiddycel need a suitable syllabus in order to make those eight intelligences well developed. This research is aimed to design the syllabus based on learners’ MI profile. The data are gathered from Kindergarten students by conducting need analysis. All of them are around 4-5 years old. The researcher collected the data by distributing questionnaire to the teacher observing and interviewing the learners. In analyzing the data the researcher used description. It means
that the researcher analyzed the data using descriptive approach. From the questionnaire, the researcher found that learners at Kiddycel National Plus School have multiple intelligence. From 9 children, there were eight children have combination leading intelligences. In observing and
interviewing the learners , the researcher found that their interest mostly the same, but they have various favorite dealing with certain topics asked. Dealing with the results, the researcher together with the class teacher
designed a task-based syllabus. This syllabus focused on the activities as the basic unit of the syllabus. The activities were designed in order to help the learners in developing their multiple intelligences.
Exercise induced alterations in NK-cell cytotoxicity - methodological issues and future perspectives.

Field: Medicine (Health Sciences)

With their ability to recognize and eliminate virus-infected and neoplastic cells, natural killer cells (NK-cells) represent an important part of the innate immune system. NK-cells have attracted the attention of exercise scientists for more than thirty years ago. To date, it is widely accepted that NK-cell counts in the peripheral blood are strongly influenced by acute exercise. Additionally, many studies reported effects of both, acute and chronic exercise on NK-cell cytotoxicity. However, these findings are contradictory. The inconsistence in findings may be argued with different exercise paradigms (type, duration, intensity). Moreover, strongly varying methods were used to detect NK-cell cytotoxicity. This review gives an overview of studies, investigating the impact of acute and chronic exercise on NK-cell cytotoxicity in young and old healthy adults, as well as on specific populations, such as cancer patients. Furthermore, different methodological approaches to assess NK-cell cytotoxicity are critically discussed to state on inconsistent study results and to give perspectives for further research in this field.
Prednisolone inhibits SaOS2 osteosarcoma cell proliferation by activating inducible nitric oxide synthase

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

AIM:To investigate the effect of prednisolone, a synthetic glucocorticoid used in inflammatory diseases, on the growth of cultured osteosarcoma cells. METHODS:Two osteosarcoma cell lines with different degree of differentiation were used.SaOS2 show a rather mature phenotype, while U2OS are negative for almost all osteoblastic markers.The cells were exposed to different concentrations of prednisolone (1-9 µmol/L) with or without antioxidants or the inhibitor of inducible nitric oxide synthase (iNOS) l-N 6 53April 12, 2016|Volume 5|Issue 1| WJTM|www.wjgnet.com
Tracking the Latino Gender Gap: Gender Attitudes across Sex, Borders, and Generations

Field: Social Sciences (Social Sciences)

Many cultural stereotypes exist regarding the “modernity” of values possessed by Latino immigrants, particularly in reference to gender norms. Common perceptions about Latin machismo and marianismo (the idea that women should be pure and moral) do not paint a portrait of gender egalitarian dispositions. These assessments are upheld by neomodernization theorists who specifically identify gender attitudes as a critical element of modernity. In applying a revised modernization theory to the issue of comparative gender values, Inglehart and Norris (2003, 10) hypothesize that development “brings about changed cultural attitudes toward gender equality in virtually any society that experiences the various forms of modernization linked with economic development.” The idea that gender equality norms develop gradually, as a function of modernization, gives rise to different expectations about accepted gender roles in developing countries as opposed to those in advanced industrial democracies. Another feature of this modernization process is the emergence of gender gaps in political behavior and attitudes. Inglehart and Norris (2000) distinguish between traditional gender gaps found in postcommunist and developing societies (in which women are more conservative in their behavior and cultural attitudes relative to men) and modern gender gaps evident in postindustrial societies (in which women are more progressive than men).
Experiences and challenges during implementation of the Blominmäki sewage tunnels, Espoo, Finland

Field: Engineering (Physical Sciences)

The sewage tunnels of the Blominmäki Wastewater Treatment Plant (WWTP) consist of approximately 20 kilometers of inlet and discharge tunnels, access tunnels and shafts. The most challenging and technically critical parts of the Finnoo II contract were: The connection of the operating offshore tunnel of the old treatment plant with the Blominmäki discharge route, through a vertical shaft. Lack of information regarding the exact location, the shape and the geological conditions of the existing tunnel called for an accurate excavation design to avoid a potential tunnel collapse and rock blocking or massive waterflow during breakthrough. The precise implementation of the connection between acceleration and pumping underground caverns. The connection, in addition to the demanding excavation of complex geometry caverns, also included the implementation of six openings of square cross-section, slightly inclined, to install pipes for the flow of the treated wastewater.
Effect of Hydrostatic Pressure on the Pitting Corrosion Behavior of 316L Stainless Steel

Field: Engineering (Physical Sciences)

The pitting corrosion behavior of 316L stainless steel (316L SS) was investigated by electrochemical measurements, nanoindentation and microscopy observation. The experiment results have been analyzed based upon the stochastic theory. Pitting initiation process has been modeled as anonhomogeneous Poisson process and analyzed using a Weibull distribution function. Pitting growth process has been simulated by a nonhomogeneous Markov process and analyzed using Gumbel distribution function. The analysis results revealed that hydrostatic pressure had three effects on the pitting corrosion behavior of 316L SS: (1) the increasing hydrostatic pressure enhance the mechanical properties of passive film; (2) the increasing hydrostatic pressure retarded the B1 process and accelerated the A3 process; (3) the pitting growth probability decreased with the increase of hydrostatic pressure. The above three factors led to the improvement of pitting corrosion resistance of 316L SS with the increasing of hydrostatic pressure.
James and Politics

Field: Arts and Humanities (Social Sciences)

Abstract William James never developed a comprehensive political philosophy. The radically pluralist epistemology and metaphysics for which “pragmatism” became his shorthand represented a revolt against all closed systems of thought. Yet James’s very resistance to certainty and finality led him to participate actively in civic life. Varying by context, this activity was consistently guided by James’s pragmatist accounts of individual experience, moral obligation, and social interdependence, which to him implied a collective, ongoing responsibility to balance freedom, justice, and order amid complexity and change. Though providing no detailed blueprint for achieving and maintaining that balance, James’s writings suggest a suite of practices and institutions that, in various forms and degrees, have proven effective in the past and deserve continued trial. These writings also articulate a regulative ideal by which to evaluate all such experiments: an ideal of popular participation in all levels of social ordering that James described, toward the end of his life, as “radical democracy.”
Consistency and Variability in Talk about "Diversity": An Empirical Analysis of Discursive Scope in Swiss Large Scale Enterprises

Field: Social Sciences (Social Sciences)

Traditionally discussions of "diversity" in organizations either refer to an ideal "management" of a diverse workforce or to specific concerns of minorities. The term diversity, however, entails a growing number of translations. Highlighting this diversity of diversity, the concept cannot be merely conceived of as either social-normative or economic-functional. Therefore, the present study empirically scrutinizes the current scope of diversity-talk in Swiss large scale enterprises from a discursive psychological perspective. First, it provides five so-called interpretative repertoires which focus on: image, market, minorities, themes, and difference. Second, it discusses why and how persons oscillate between consistency and variability whenever they draw upon these different repertoires. Finally, it points out possibilities to combine them. This empirical approach to diversity in organizations offers new aspects to the current debate on diversity and introduces crucial concepts of a discursive psychological analysis. URN: urn:nbn:de:0114-fqs090218
Travelling in the Roman Mediterranean : a GIS approach

Field: Social Sciences (Social Sciences)

This thesis applies new methods to understanding and interpreting the structure of the Mediterranean basin through three different specific studies (chapters 5 to 7), each of which applies several different GIS technologies to create a theoretical model of the wind and wave environment of the Mediterranean during the period of the Roman Empire.<br/><br/>The first of these studies the Mediterranean in terms of its geomorphology, and considers possible movement between areas of the Roman Empire.<br/><br/>The second examines the interconnectivity properties between different port locations in the Mediterranean basin using routes between different known locations and spheres of contact.<br/><br/>The third examines the possible movement patterns along a known axis of travel between two documented port locations in the Mediterranean basin.
The Vinylcyclopropane−Cyclopentene Rearrangement:  A Prototype Thermal Rearrangement Involving Competing Diradical Concerted and Stepwise Mechanisms

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThe Vinylcyclopropane−Cyclopentene Rearrangement: A Prototype Thermal Rearrangement Involving Competing Diradical Concerted and Stepwise MechanismsK. N. Houk, Maja Nendel, Olaf Wiest, and Joey W. StorerView Author Information Department of Chemistry and Biochemistry University of California Los Angeles, California 90095-1569 Department of Chemistry and Biochemistry University of Notre Dame, Notre Dame, Indiana 46556 Cite this: J. Am. Chem. Soc. 1997, 119, 43, 10545–10546Publication Date (Web):October 29, 1997Publication History Received25 April 1997Revised11 August 1997Published online29 October 1997Published inissue 1 October 1997https://doi.org/10.1021/ja971315qCopyright © 1997 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1627Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (178 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical structure,Energy,Hydrocarbons,Rearrangement,Stereoselectivity Get e-Alerts
Legal form

Field: Arts and Humanities (Social Sciences)

This chapter considers the theory and politics of international legal formalism. I argue that we ought to acknowledge the full implications of the insight that international law is anchored in extralegal dynamics while being informed by relatively autonomous structures of its own. Broached from this sociolegal perspective, antiformalism today should be understood not as a grand theoretical innovation, to be lauded or lambasted, but as a piece of commonplace wisdom, fully capable of being absorbed into any neoformalism that has come to terms with the legal realist challenge, distanced itself from bourgeois models of internal coherence and immanent intelligibility, and adopted the crucial, if somewhat prosaic, goal of supplying weaker actors with at least a limited measure of defensive tools. The truly pressing question today, I contend, is not whether to be a formalist, but how one ought to be a formalist.
A local-to-global result for topological spherical buildings

Field: Mathematics (Physical Sciences)

Abstract Suppose that Δ;Δʹ are two buildings each arising from a semisimple algebraic group over a field, a topological field in the former case, and that for both the buildings the Coxeter diagram has no isolated nodes. We give conditions under which a partially defined injective chamber map, whose domain is the subcomplex of Δ generated by a nonempty open set of chambers, and whose codomain is Δʹ, is guaranteed to extend to a unique injective chamber map. Related to this result is a local version of the Borel-Tits theorem on abstract homomorphisms of simple algebraic groups.
Boxing, kickboxing, combat section sambo as means of special physical training in forming students' skills and skills for self-defense

Field: Social Sciences (Social Sciences)

The purpose of the study was to clarify the views of the authors on the methodological features of using sports training in martial arts (boxing, kickboxing, combat section of sambo) as a special physical training of students (civilians) for self-defense. In the work, a theoretical analysis of general characteristics and components in the directions of the educational and training process of various types of martial arts is carried out; separate signs of common features and differences are highlighted for synthesis into a comprehensive preparation for self-defense in extreme situations of confrontation with criminal attacks on a civilian. The novelty of the study should be considered the views proposed by the authors on the adaptation of the experience of some methodological features in the training of law enforcement officers to confront offenses by means of physical influence to the process of training students (civilians) for self-defense. The conclusions indicate the possibility of preparing students for self-defense by means of martial arts (boxing, kickboxing, combat section of sambo) with the provision of tactical, psychological, and legal training.