jimnoneill/paper-to-field-training huggingface dataset:
Additional file 2 of CAR T cells targeting CD99 as an approach to eradicate T-cell acute lymphoblastic leukemia without normal blood cells toxicity

Field: Medicine (Health Sciences)

Additional file 2: Fig. S1. (f) Binding kinetics of anti-CD99 antibodies (1021527 and 3B2/TAB) with CD99 protein. Analysis of the interaction between the antibodies and CD99 protein using BLItz biolayer interferometry. (g) The CD99 expression level in NIH 3T3 human CD99-overexpression cell line, and anti-CD99 CAR T cells specifically lysis efficiency at different effector-to-target ratios (1:1/5:1/25:1). (h) The CD99 expression level in MOLT-4 human CD99 knockdown cell line, and anti-CD99 CAR T cells specifically lysis efficiency at effector-to-target ratios (25:1). (i) The gating strategy of blast cells from T-ALL patients and the CD99 expression level in four patients’ blasts (The detail information showed in the Additional file 5: Table S1).
Magnetic Field Structures in Star Forming Regions: Mid-Infrared Imaging Polarimetry of K3-50

Field: Physics and Astronomy (Physical Sciences)

We report new imaging polarimetry observations of the Galactic compact HII region K3-50 using CanariCam at the Gran Telescopio Canarias. We use a standard polarimetric analysis technique, first outlined by Aitken, to decompose the observed polarisation images centred at 8.7, 10.3, and 12.5 $μ$m into the emissive and absorptive components from silicate grains that are aligned with the local magnetic field. These components reveal the spatially-resolved magnetic field structures across the mid-infrared emission area of K3-50. We examine these structures and show that they are consistent with previously observed features and physical models of K3-50, such as the molecular torus and the ionised outflow. We propose a 3D geometry for all the structures seen at different wavelengths. We also compute relevant physical quantities in order to estimate the associated magnetic field strengths that would be implied under various physical assumptions. We compare these results with MHD simulations of protostar formation that predict the magnetic field strength and configuration. We find that the magnetic field may be dynamically important in the innermost 0.2 pc of the molecular torus, but that the torus is more likely to be rotationally-supported against gravity outside this radius. Similarly, magnetic fields are unlikely to dominate the {\em global} physics of the ionised outflow, but they may be important in helping confine the flow near the cavity wall in some locations. Ours is the first application of the Aitken technique to spatially-resolved magnetic field structures in multiple layers along the line of sight, effectively a method of "polarisation tomography."
The influence of minimum wage regulation on labor income share and overwork: evidence from China

Field: Economics, Econometrics and Finance (Social Sciences)

Minimum Wage Regulation (MWR) can raise wage rate, but its relation with labor income share is in controversy. We explore the influence of raising wage rate on labor income share and overwork in China. Panel data regressions are taken mainly based on China’s Industrial Enterprise Database and the International Labor Organization Database. Our findings show that raising wage rate can increase labor income share without leading to overwork. Factors that may significantly increase overwork are a higher proportion of male workers, a larger income gap and a lower per-capita income. We point out that the neoclassical explanation for labor income share is not persuasive. We support policies of raising wage rate and believe MWR is an effective measure to increase labor income share.
A Tale of Two Tweets: What Factors Predict Forgiveness of Past Transgressions on Social Media?

Field: Psychology (Social Sciences)

As more of our lives take place online, it is increasingly common for public figures to have their current image tarnished by their mistakes and transgressions in what is often the distant past. Three experiments ( N = 2,296) found that judgments of a public figure who tweeted racist statements in the past were less harsh when more time had passed and when the public figure was younger at the time of the tweet. However, politics also played a powerful role. Independent of time and age, liberals allowed less possibility of redemption for anti-Black tweets, while conservatives were less forgiving for anti-White tweets. Such partisan differences extended not only to moral judgments of the individual, but also general moral principles and participants’ subjective perceptions of the situation itself, including subjective temporal distance from the tweet, the subjective age of the public figure, and the current relevance of the past statements.
Tingkat Kecemasan pada Lansia yang Dilakukan Terapi Teknik Relaksasi Otot Progresif dan Terapi Reminiscence

Field: Health Professions (Health Sciences)

Anxiety experienced by the elderly in Indonesia is very high. Anxiety disorders in the elderly reach 5.5%, which is often experienced by those aged 60 years and over. The purpose of this study was to determine the effect of progressive muscle relaxation techniques and reminiscence therapy on the level of anxiety in the elderly. This research is a quasi-experimental study, with a total sampling technique of 30 respondents who were divided into 2 groups. The instrument in this study used HARS. Data analysis using paired samples test and GLM. The results showed a decrease in anxiety levels after the intervention with p-value=0.000. The results obtained in these two interventions were a p-value of 0.000<0.05, it can be concluded that there was a change in the value of decreasing anxiety in the elderly before and after the progressive muscle relaxation technique and reminiscence therapy was carried out. Suggestions for further researchers need to do similar research with the addition of a larger number of respondents. Therefore, intervention was carried out not in groups, and different sample criteria were carried out to get maximum results.
Nucleation, instability and discontinuos phase transitions in the monoaxial helimagnet with oblique fields

Field: Physics and Astronomy (Physical Sciences)

A robust and extended characterization of the point spread function (PSF) is crucial to extract the photometric information produced by deep imaging surveys. Here, we present the extended PSFs of the Sloan Digital Sky Survey (SDSS), one of the most productive astronomical surveys of all time. By stacking similar to 1000 images of individual stars with different brightness, we obtain the bidimensional SDSS PSFs extending over 8 arcmin in radius for all the SDSS filters (u, g, r, i, z). This new characterization of the SDSS PSFs is near a factor of 10 larger in extension than previous PSFs characterizations of the same survey. We found asymmetries in the shape of the PSFs caused by the drift scanning observing mode. The flux of the PSFs is larger along the drift scanning direction. Finally, we illustrate with an example how the PSF models can be used to remove the scattered light field produced by the brightest stars in the central region of the Coma cluster field. This particular example shows the huge importance of PSFs in the study of the low-surface brightness Universe, especially with the upcoming of ultradeep surveys, such as the Large Synoptic Survey Telescope (LSST). Following a reproducible science philosophy, we make all the PSF models and the scripts used to do the analysis of this paper publicly available (snapshot v0.4-0-gd966ad0). ©2019 The Author(s) \nPublished by Oxford University Press on behalf of the Royal Astronomical Society
Toxicological assessment and inseсtoacaricid efficiency of the preparations «RolfСlub 3D Spray for Dogs» and «RolfСlub 3D Spray for Cats»

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The toxicological assessment is given and efficiency of complex preparations is studied. «RolfClub 3D spray for dogs» contains fipronil, D-cifenotrin, piriproxi-fen; «RolfСlub 3D spray for cats» – fipronil, etofenprox, piriproxifen. Preparations represent solution and are applied spot on as spray. Parameters of acute and skin toxicity of preparations for dogs and for cats are determined. LD50 at introduction in a stomach to mice made 5809±508,6 and 4295±607 mg/kg respectively, LD50 when drawing on skin to rats – more than 30000 mg/kg (the 4th class of danger). Preparations don't possess local irritating action. At application in twice and five time increased doses during 7 days have no negative impact on the general condi-tion of dogs and cats, their physiological status and behavior, don't change morpho-logical structure and biochemical indicators of blood and urine. Preparations pos-sess accurately expressed insektoakaricid activity on all stages of development of fleas, louses, ticks of the genius Sarcoptes and Demodex. Preparations don't cause side effects and complications.
Time-Varying Liquidity and Momentum Profits

Field: Economics, Econometrics and Finance (Social Sciences)

A basic intuition is that arbitrage is easier when markets are most liquid. Surprisingly, we find that momentum profits are markedly larger in liquid market states. This finding is not explained by variation in liquidity risk, time-varying exposure to risk factors, or changes in macroeconomic condition, cross-sectional return dispersion, and investor sentiment. The predictive performance of aggregate market illiquidity for momentum profits uniformly exceeds that of market return and market volatility states. While momentum strategies have been unconditionally unprofitable in the United States, in Japan, and in the Eurozone countries in the last decade, they are substantial following liquid market states.
Nonlinear Optical Microscope: A History of Interplay between Technology Developments and Biomedical Sciences

Field: Neuroscience (Life Sciences)

The field of nonlinear optical (NLO) microscopy has enjoyed vibrant development over the past two decades. Advances in NLO microscopy offers more sensitive, deeper and faster imaging. More importantly, NLO has grown from its root in fluorescence to a broad range of contrast mechanisms. These technological advances have broad impact on biology and medicine. Using the area of neurobiology as an example, this presentation seeks to highlight key technical advances and their biomedical impact. Article not available.
Development and Interrupting Tests on 250KV 8KA HVDC Circuit Breaker

Field: Engineering (Physical Sciences)

This paper describes the circuit and component selections, development and equivalent circuit test results on an HVDC circuit breaker for an HVDC transmission line. A puffer type SF6 gas interrupter for AC circuit breakers is utilized for interrupting DC current with injection of high-frequency inverse current from a commutating capacitor precharged to HVDC line voltage. Also, the effectiveness of application of the HVDC breaker to an HVDC system with two parallel transmission lines is demonstrated through the EMTP simulation.
A Case of Transition from Fixed Bridge to Implant Restoration in Maxillary Anterior Region

Field: Dentistry (Health Sciences)

症例の概要：患者は52歳の女性．上顎前歯部審美障害を主訴に来院，装着されているブリッジの支台歯は一部が保存不能と診断，抜歯となった．その結果，上顎切歯4歯連続欠損となったが，患者が固定性修復を強く希望，また両隣在歯を削りたくないとのことから同部にインプラントによる修復を行った．考察：ブリッジによる修復を行う場合，歯の切削を伴う．本症例ではインプラントを用い，これを支台とすることで健全歯の保存を行うことができた．結論：前歯部中間欠損に対してブリッジからインプラント修復への移行により残存歯の保全が図られ，審美性，機能性からも満足が得られ，有効な治療法であることが示された．
Sepsis risk assessment: a retrospective analysis after a cognitive risk management robot (Robot Laura®) implementation in a clinical-surgical unit

Field: Health Professions (Health Sciences)

Abstract Introduction This study aimed at evaluating the impact of the implementation of a cognitive robot (Robot Laura™) on processes related to the identification and care of patients with risk of sepsis in a clinical-surgical unit of a private hospital in Curitiba-PR. Methods The study data were obtained from the retrospective review of medical records of patients identified with infection and/or sepsis, in the period of six months before and after the implementation of such technology in the hospital. In addition, the Average Attendance Time (AAT) was obtained from the autonomous reading of the robot. Results The average time/median until antibiotic prescription from the first identified sign of infection, with or without sepsis, was 390/77 and 109/58 minutes, respectively, in the six months before and after implementation of the technology. However, this difference was not statistically significant (p = 0.85). Regarding AAT, it was possible to observe a reduction from 305 to 280 minutes when comparing the periods of six months before and after the implementation of the technology (p = 0.02). Conclusion Technologies such as this may be promising in helping healthcare professionals to identify risky situations for patients, as well as in assisting them to optimize the care required. However, further studies, with a greater number of subjects and with different scenarios, are necessary to consistently validate the results found.
Diagnosis and treatment of AO-B type ankle joint fracture combined with distal tibiofibular syndesmosis injury

Field: Medicine (Health Sciences)

Objective To explore the diagnosis and effect of surgical treatment for AO-B type ankle joint fracture combined with distal tibiofibular syndesmosis injury.Methods From July 2010 to December 2012,42 patients with AO-B type ankle joint fracture combined with distal tibiofibular syndesmosis injury were treated by surgical treatment.There were 30 cases of trimalleolar fracture,6 cases of bimalleolar ankle fracture,6 cases of bimalleolar fracture with deltoid ligament rupture.During the operation,the lateral malleolus should be reduced and fixed before the posterior and medial malleolus,then fixed the distal tibiofibular syndesmosis.The curative effect was evaluated with American Orthopaedic Foot and Ankle Society(AOFAS)ankle-hindfoot scale.Results Forty patients were followed up for 10 to 26 months(average,14.3±0.5 months).All fractures were union.There was 1 case of wound delayed heal.No wound infection and necrosis occured.The score of AOFAS ankle-hindfoot scale was 87.1±2.16 at 6 months,and 93.4±2.31 at 12 months postoperatively(P0.01).The last follow-up,26 feet(65.0%)were excellent,10 feet(25.0%)were good,6 feet(10.0%)were middle,the excellent and good rate was 90.0%.Conclusion It is important to accurately evaluate whether or not combined with distal tibiofibular syndesmosis injury,and do anatomic reduction and fixation for gaining good function of AO-B type ankle joint fracture.
Antidiabetic Potential of Ficus glomerata Roots with a Special Emphasis on Estimation of Bioactive Compounds by a Novel Validated HPTLC Technique

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract: Background: The data presented in this article for Ficus glomerata Linn. belonging to family Moraceace which is commonly found all over India. This study aimed towards the development and validation of high-performance thin-layer chromatography (HPTLC) method for simultaneous estimation of lupeol and quercetin from Ficus glomerata and correlate with its antidiabetic potential. Methods: The various fractions of ethanolic extract of Ficus glomerata root were prepared. The HPTLC analysis of quercetin and lupeol which are the important phytoconstituents responsible for various pharmacological actions was carried out at 525 nm. ICH guidelines were followed to validate this method for accuracy, precision and repeatability. Results: The linearity range of quercetin and lupeol were obtained as 400-2400 ng/spot and 1000- 5000 ng/spot respectively. Percent drug content was highest in diethyl ether fraction (quercetin 2531.8 ng and lupeol 1400 ng). The limit of detection value (LOD) obtained for quercetin and lupeol was 3.0793 and 3.1645 ng and the limit of quantification (LOQ) was 9.3314 and 9.5895 ng respectively. This method developed was accurate, precise and simple has shown higher resolution from other phytoconstituents present in the fractions. The method can be very effectively applied for analyzing the quality of herbal material and formulations containing Ficus glomerata. Antidiabetic activity of various fractions of ethanolic extract of Ficus glomerata roots was studied on alloxan-induced diabetic rats. Treatment with fractions was continued for 11 days. The effect of the fractions on glucose was analyzed. Diabetic rats treated with diethyl ether fraction exhibited a significant (p<0.05) decrease in glucose levels, indicating the potential use of Ficus glomerata in diabetes mellitus. Conclusion: As per the ICH guidelines, the HPTLC method used for simultaneous estimation of lupeol and quercetin was accurate, precise and specific. The method used for phytochemical standardization of various fractions of ethanolic extract of the roots of Ficus glomerata and correlated with its antidiabetic activity. Key words: Ficus glomerata, HPTLC, Lupeol, Quercetin, Alloxan, Antidiabetic activity
Fostering enterprise architecture education and training with the enterprise architecture competence framework

Field: Business, Management and Accounting (Social Sciences)

Enterprise architecture (EA) implementation refers to a set of activities ultimately aiming to align business objectives with information technology infrastructure in an organization. EA implementation is a multidisciplinary, complicated and endless process, hence, calls for adequate education and training programs that will build highly skilled personnel (called enterprise architects) with diverse competencies. This development of domain‐specific competencies is also supported by European policies on education and vocational training. To this end, the authors present training uses of the Enterprise Architecture Competence Framework (EA‐CF). EA‐CF is a proposed conceptual model that describes EA competencies in compliance to the European e‐Competence Framework (e‐CF). The authors argue that EA stakeholders can consult the framework regarding competencies they want to underpin and thus identify the corresponding skills, knowledge and attitudes that result as learning outcomes in EA courses and training programs.
Data from Aurora A Regulates Prometaphase Progression by Inhibiting the Ability of RASSF1A to Suppress APC-Cdc20 Activity

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<div>Abstract<p>The Aurora (Ipl) kinase family plays important roles in the regulation of mitosis and tumorigenesis. The tumor suppressor RASSF1A controls mitotic progression by regulating anaphase-promoting complex (APC)-Cdc20 activity and microtubule stability, but the mechanism by which this action is regulated has not been previously established. Here, we show that Aurora A and B associate with and phosphorylate RASSF1A on serine 203 <i>in vivo</i> at different times and in different subcellular compartments during mitosis. Notably, both depletion of Aurora A by RNA interference and expression of a nonphosphorylatable RASSF1A (S203A) mutant gene led to a marked delay in prometaphase progression. This is likely because of the failure of RASSF1A to dissociate from Cdc20, constitutive inhibition of APC-Cdc20, and accumulation of mitotic cyclins. In contrast, the delay in prometaphase progression caused by Aurora A depletion was largely normalized by phosphomimetic RASSF1A (S203D). Finally, RASSF1A phosphorylation on serine 203 was up-regulated in Aurora A–overexpressing human tumors. These findings indicate that Aurora A plays a critical role in RASSF1A-APC-Cdc20 regulatory mechanisms that control normal prometaphase progression and that are involved in tumorigenesis. [Cancer Res 2009;69(6):2314–23</p></div>
Levator Ani Avulsion in Ultrasound Increases Recurrence in Sacrospinous Fixation

Field: Medicine (Health Sciences)

Importance Pelvic floor translabial ultrasound (TLUS) can identify levator ani muscle (LAM) avulsion and ballooning, which some studies have shown to be possible risk factors for prolapse recurrence. Our group uses TLUS to counsel patients preoperatively. If any of these risk factors exist, we offer sacrocolpopexy over vaginal repair. However, some patients, even though they have these possible risk factors, prefer to undergo vaginal surgery. Objective The objective of this study was to determine if TLUS LAM avulsion and/or ballooning are risk factors for composite outcome recurrence in patients undergoing sacrospinous ligament fixation for pelvic organ prolapse. Study design This was a retrospective observational study. All patients with vaginal apical repair with sacrospinous ligament fixation with preoperative TLUS were included. Demographics, clinical characteristics, and follow-up were analyzed. Multivariable logistic regression analysis was performed for composite outcome that included TLUS risk factors, age, Pelvic Organ Prolapse Quantification System measurements and stage, and variables with P < 0.1 in the univariate analysis. Results Eighty-two patients were included. All patients had symptomatic vaginal bulge; 65.4% had stage III prolapse. Concomitant hysterectomy was performed in 54.3%. Median follow-up was 20 months (interquartile range, 8–35 months); 19.8% had LAM avulsion, and 43.2% had ballooning. Anatomic recurrence rate was 23.5%, symptomatic was 22.2%, and reoperation was 1.2%. The composite recurrence rate was 29.6%. In the multivariable logistic regression analysis, unilateral/bilateral avulsion in TLUS was found to be a significant risk factor for composite outcome with an odds ratio of 4.33 (confidence interval, 1.219–15.398; P = 0.023). Conclusions Composite outcome of recurrence in our study was 29.6%. Avulsion on TLUS increased the risk of recurrence of pelvic organ prolapse by fourfold.
Interview process learning for top-n recommendation

Field: Computer Science (Physical Sciences)

In the field of recommendation system research, a key challenge is how to effectively recommend items for new users, a problem generally known as cold-start recommendation. In order to alleviate cold-start problem, recently systems try to get the users' interests by progressively querying users' preference on predefined items. Constructing the query process via machine learning based techniques becomes an important direction to solve cold-start problem. In this paper, we propose a novel interview process learning algorithm. Different from previous approaches which focus on rate prediction, our model is able to handle wide ranges of loss functions and can be used in collaborative ranking task. Experimental results on three real world recommendation dataset demonstrate that our proposed method outperforms several baseline methods.