jimnoneill/paper-to-field-training huggingface dataset:
Integrated Active Learning Tools for Enhanced Pedagogy in a Software Engineering Course

Field: Computer Science (Physical Sciences)

Abstract Integrated Active Learning Tools for Enhanced Pedagogy in a Software Engineering CourseEffective teaching requires effective teaching tools. This pedagogical requirement is especiallyimportant for software engineering education where graduates are expected to develop softwarethat meets rigorous quality standards in functional and application domains. To enhancestudent's understanding of the needs of the professional software industry, lecture notes aresupplanted by additional pedagogical tools being developed at author's institution for a softwareverification and validation (V&V) course. These active learning teaching tools consisting ofclass exercises, case studies, and role play videos are being developed by partnering with theacademia and industry. The basic objectives of the project are to improve software education tomake it well aligned with academic research as well as industry best practices. This project isbeing funded through a NSF-TUES grant.Through this project twenty (20) delivery hours of lecture slides, eighteen (18) delivery hours ofcase studies, sixteen (16) delivery hours of exercises, and six (6) delivery hours of role playvideo totaling sixty (60) delivery hours of Software V&V course modules are being created. Inspring 2014 diverse case studies were delivered to Software Engineering juniors in the author'sinstitution and their learning outcomes tracked using a survey instrument. The results show thatthe students were able to better comprehend V&V topics like requirements engineering, reviewsand inspections, configuration management, and testing. The knowledge disseminated throughlectures seemed to be reinforced by the case studies. By spring 2015 more course materialsincluding teaching tools like exercises and role-play videos are expected to be created anddelivered. The results of this research work will be shared during the poster presentation atASEE. As part of the project dissemination plan the teaching materials will be made available tointerested institutions and professional organizations. An invitation only workshop is alsoplanned for August 2015 to share developed course materials and delivery mechanism.
ARA-RCIV: Identifying Reliability-Critical Input Vectors of Logic Circuits Based on the Association Rules Analysis Approach

Field: Computer Science (Physical Sciences)

The identification of reliability-critical input vectors (RCIVs) is vital in the assessment and prediction of reliability boundaries for logic circuits. This article introduces an approach grounded in association rule analysis (ARA) to swiftly and efficiently identify RCIVs in both combinational and sequential circuits. The utilization of the ARA model for validating the circuit's associated primary inputs enhances accuracy while simultaneously reducing the complexity of RCIVs identification. Orienting the generation of new samples with associated inputs expedites the identification process. Quantifying circuit complexity enables the adaptive assignment of algorithmic parameters to circuits of diverse sizes. The construction of input sets facilitates a precise evaluation of the reliability of individual input vectors in sequential circuits. Experimental results on benchmark circuits illustrate that this approach achieves a mean accuracy of 0.9952, with Monte Carlo (MC) method serving as the reference, for small and medium-sized circuits, and require only 20.71% of MC's time overhead. The average coverage of 0.9884 surpasses the reference method by 1.8 times. The stability is 4.35 times higher with the random method on large scale circuits with 224,624 gates and 6,642 primary inputs. Circuit designers can swiftly ascertain the average reliability and reliability boundaries of a circuit by using this approach for RCIVs identification. By applying optimizations of the identified RCIVs to expedite convergence and mitigate fluctuations, the influence of these RCIVs can be minimized in reliability evaluation and testing.
Evaluating the Ethical Responsibility of Environmental Planning Law in Perpetuating Settler Colonialism Using a Transnational Legal Lens

Field: Social Sciences (Social Sciences)

Abstract This article investigates whether environmental planning law can demonstrate ethical responsibility for its role in settler colonialism. Planning law contributes to settler colonialism by diminishing, excluding, and eliminating alternative views of land that are fundamental to First Nations culture, philosophy, and law/lore. The article adopts a transnational legal frame that recognizes and promotes First Nations as sovereign. The investigation is focused primarily on the planning law system in New South Wales (NSW), Australia, while being guided by interpretations and applications of the rights of First Nations peoples by courts in Canada. It is argued that state planning law in NSW fails to give effect to ethical responsibility because its operation continues to dominate and marginalize Aboriginal legal culture by eroding the necessary ontological and epistemic relationships with land. However, there is potential for change. Opportunities to disrupt settler colonialism have emerged through bottom-up litigation, which has promoted interpretations, applications, and implementation of law that can be performed in ways that resonate with Canadian case law. While the absence of treaty or constitution-based rights protection in NSW and Australia means that the transplant is not seamless, the article argues that laws should not be interpreted and applied in ways that perpetuate settler colonialism where alternative interpretations can lead to a different outcome.
Sequential Gaussian and Indicator Simulation with Location- Dependent Distributions and Statistics

Field: Mathematics (Physical Sciences)

The use of location-dependent distributions and statistics is proposed for geostatistical simulation under the assumption of local stationarity. The local distributions and statistics are obtained using distance weighting functions. For Sequential Gaussian Simulation, the Gaussian transformation of each local distribution embeds the local changes in the local mean, variance and histogram shape. The same weights used for inferring the local distribution modify the local measures of spatial continuity, which adapt to local variations informed by data. The local Gaussian transformations are modelled by Hermite polynomial series and the resulting coefficients are stored. The local measures of correlation are fitted semiautomatically and, as for the Hermite coefficients, the resulting parameters are stored at the resolution of the simulation grid. The sequential simulation algorithms read these local parameters, update the local distribution, retransform the data, and recalculate the covariance at every location. This increases considerably the demand of computer resources. However, the resulting models are richer in local information. These models are accurate and can be more precise compared to those generated by stationary techniques. Locally stationary indicator simulation models offer a better reproduction of the connectivity observed in categorical data.
C2 –C0 VALUES DETERMINATION FOR MONITORING CYCLOSPORINE THERAPHY IN STABLE HEART TRANSPLANTED PATIENTS

Field: Medicine (Health Sciences)

O340 Aims: The cyclosporine two hours plasmatic level determination (C2) seems to be better related to safety and efficacy of immunosuppressive regimen than throught level (C0) in stable and “the novo” liver and kidney transplanted patients. There are not clear results about the safe and efficacy of C2 level compared to C0 in the immunosuppressive regimen of stable transplanted heart; this study have been performed in stable transplanted heart to determine efficacy and safety of C2 versus C0. Methods: From 01/09/01 to 15/03/04, 1148 samples (574 C0 determination and related C2) were taken to 110 stable and “the novo” heart transplanted patients, orally treated with Neoral micro-emulsioned Cyclosporine (Cya) and monitored with C0 trought levels. From this population, 60 patients with a sufficient number of samples/patient (at least 4) with a mean ratio of 5,2, were studied and divided in two subgroups: Group A, 22 patients with a relatively constant C2 and related AUC values (“costant” defines as +/- 30% in four different samples) and: Group B, 38 patients “inconstant adsorbers”, with great variation (> +/- 30%) of C2 values despite constant given cyclosporine dosage. Cya side effects, acute rejection episodes and chronic graft rejection were observed and related to C2 measured levels. Results: Total number of biopsies was 427; 21 episodes of acute rejection ISHLT grade > IIIA occurred (21/427, 4,9%). There was no statistical difference between number of acute rejection in the two groups. Only 7 rejection episodes occurred in transplanted patients over 1 year; in the others events, there was no difference about immunosuppressive treatment (triple standard : Cya+prednisone+ azathioprine). In the patients free of rejection, mean C2 level observed were: 1500 ng/ml (range 1180-1890) at three months from transplantation, 1200 ng/ml (range 1050-1630) at 6th month, 1000 ng/ml (range 650-1440) at 1 year, 750 ng/ml (range 550-970) at two years. Higher C2 levels were related to increased frequency of Cya side effects: sistemic hypertension (47% group A vs 36% group B), gum hyperplasia (A 21% vs B 9%), hypercolesterolaemia (A 42% vs B 22%), tremors and peripheral paraestesia (A 47% vs B 31%). There were no differences between the two group regard renal disfunction. Conclusions: Despite the small number of patients C2 levels determination appears to be very helpfull when associated to C0 in clinical monitoring of immunosuppression (identification of Cya over-exposed and low-adsorber patient). In heart transplanted patients the recommendable C2 levels appeares to be higher in respect to liver or kidney transplanted patients. Because of an higher dosage of Cya, C2 monitoring alone can be associated to an higher report of side effects than in liver and kidney transplantation.
State Feedback Controller Design for Discrete-Time Linear System with Time-Varying Delay Using a New Lyapunov-Krasovskii Functional

Field: Computer Science (Physical Sciences)

This paper presents the stabilization problem of linear discrete-time systems with time-varying delay using a new Lyapunov-Krasovskii (LK) functional. A tighter estimate of the forward difference of LK functional is obtained by invoking the summation inequality and reciprocally convex combination lemma. A delay-dependent condition for the existence of state-feedback controller is derived in linear matrix inequality (LMI) framework which ensures asymptotic stability in the sense of Lyapunov. The effectiveness of the proposed results is demonstrated through numerical examples.
Use of inelastic design for radioactive material transportation packages

Field: Engineering (Physical Sciences)

There is much interest within the radioactive material transportation container design community in the use of inelastic analysis. In other industries where inelastic analysis is used in design there is typically an improved knowledge of the capacity of the structure and a more efficient use of material. This report describes the results of a program in which the incentives for inelastic analysis for radioactive material transport container design were investigated to determine if there are similar benefits. Detailed are the elastic and inelastic analyses of two containers subjected to impacts onto a rigid target following a thirty-foot free fall in end-on, side-on, and center-of-gravity- over-corner orientations.
Efficient gene delivery to the inflamed colon by local administration of recombinant adenoviruses with normal or modified fibre structure

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

BACKGROUND/AIMS Replication deficient recombinant adenoviruses represent an efficient means of transferring genes in vivo into a wide variety of dividing and quiescent cells from many different organs. Although the gastrointestinal tract is a potentially attractive target for gene therapy approaches, only a few studies on the use of viral gene transfer vehicles in the gut have been reported. The prospects of using recombinant adenoviruses for gene delivery into epithelial and subepithelial cells of the normal and inflamed colon are here analysed. METHODS An E1/E3 deleted recombinant adenovirus (denoted AdCMVβGal) and an adenovirus with modified fibre structure (denoted AdZ.F(pk7)) both expressing the bacterial lacZ gene under the control of a human cytomegalovirus promoter were used for reporter gene expression in vitro and in vivo. β-Galactosidase activity was determined by specific chemiluminescent reporter gene assay. RESULTS Intravenous or intraperitoneal injection of AdCMVβGal into healthy Balb/c mice caused strong reporter gene expression in the liver and spleen but not in the colon. In contrast, local administration of AdCMVβGal resulted in high reporter gene expression in colonic epithelial cells and lamina propria mononuclear cells. A local route of adenovirus administration in mice with experimental colitis induced by the hapten reagent trinitrobenzenesulphonic acid was next evaluated. Interestingly, rectal administration of AdCMVβGal caused a higher β-galactosidase activity in isolated lamina propria cells from infected mice with experimental colitis than in those from controls. Furthermore, isolated lamina propria cells from mice with colitis infected in vitro showed a significant increase in reporter gene activity compared with controls. Finally, AdZ.F(pk7) adenoviruses with modified fibre structure produced 10- to 40-fold higher reporter gene activity in spleen T cells and lamina propria mononuclear cells of colitic mice compared with standard AdCMVβGal vectors. CONCLUSIONS Local administration of recombinant adenoviruses with normal or modified fibre structure could provide a new reliable method for targeted gene expression in the inflamed colon. Such gene delivery could be used to specifically express signal transduction proteins with therapeutic potential in inflamed colonic tissue. In particular, adenoviruses with modified fibre structure may be useful in T cell directed therapies in intestinal inflammation.
ELECTRON MICROSCOPY OF POLYRIBOSOMES WITHIN BACILLUS CEREUS

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Pfister, R. M. (Syracuse University, Syracuse, N.Y.), and D. G. Lundgren . Electron microscopy of polyribosomes within Bacillus cereus . J. Bacteriol. 88: 1119–1129. 1964.—Clusters of ribosomes (polyribosomes) were identified in thin sections of Bacillus cereus . Cells were treated by freezing and thawing to induce partial lysis to permit a closer examination of structural detail. The polyribosomes were (at times) attached to the cytoplasmic membrane, and ribosome clusters contained about 10 to 55 individual ribosomes. Individual ribosomes ranged from 70 to 100 A, whereas polyribosomes were about 150 to 850 A wide. A membrane served as the fabric holding the ribosomes, which were about 50 to 100 A apart.
Episodic and Semantic Memory for Melodies in Alzheimer's Disease

Field: Neuroscience (Life Sciences)

the present study addressed episodic and semantic memory for melodies in three groups of participants: 35 younger adults, 40 older adults, and 10 individuals with mild to moderate Alzheimer's disease (AD). To assess episodic memory, a study list of eight novel target melodies was presented three times, followed by a test trial in which target melodies were mixed with foil (previously unheard) melodies. Both explicit and implicit measures were obtained. Explicit memory was assessed by the accuracy of discrimination of the target melodies from the foils. Younger adults were significantly more accurate than older adults, who in turn had significantly higher scores than AD adults. Implicit memory was assessed by examining the difference in pleasantness ratings between target and foil melodies. Younger adults showed significantly greater differences in pleasantness ratings than older adults and AD adults; scores for the two latter groups did not differ. To assess semantic memory, participants were asked to identify traditional melodies within a series of traditional and novel melodies. In contrast to the episodic memory results, all three groups showed very high scores on the semantic memory task with no significant differences among groups. The results support the notion that, though other forms of musical memory may be compromised, semantic memory for melody may be preserved in normal aging and in AD.
Assessment in the primary care of the State of São Paulo, Brazil: incipient actions in sexual and reproductive health

Field: Health Professions (Health Sciences)

ABSTRACT OBJECTIVE The objective of this study is to assess performance in sexual and reproductive health of primary health care services of the Brazilian Unified Health System, in the State of São Paulo, Brazil. METHODS An evaluative framework was built for sexual and reproductive health with the categorization of 99 indicators in three domains: sexual and reproductive health promotion (25), sexually transmitted infections/AIDS prevention and care (43), and reproductive health care (31). This framework was applied to assess the services responses to the questionnaire of Quality Evaluation of Primary Health Care in the Municipalities of São Paulo State (QualiAB), in 2010. Percentages were calculated for positive responses to indicators and performance in the sexual and reproductive health dimension, according to domains, and their contribution to the overall score in sexual and reproductive health (Friedman), relative participation (Dunn), and correlation (Spearman) was verified. RESULTS Overall, 2,735 services participated in the study. They were located in 586 municipalities (distributed throughout the 17 regional health departments of São Paulo), of which 70.6% had fewer than 100,000 inhabitants. The overall average performance of these services for sexual and reproductive health is 56.8%. The actions are characterized by: prenatal with adequate beginning and exams, better organization for immediate rather than for late postnatal care, and selective reproductive planning for some contraceptives; prevention based on specific protection, limitations in the prevention of congenital syphilis, in the treatment of sexually transmitted infections, and in the screening of cervical and breast cancer; specific educational activities, with a restricted vulnerability approach, focus on sexuality over reproduction. The domain of reproductive health has greater participation in the overall score, followed by prevention/care and promotion. The three domains are correlated; the domain of prevention/care has the highest correlation with the other ones. CONCLUSIONS The implementation of sexual and reproductive health in primary health care in the services studied is incipient. The revision of the purpose of the work, the dissemination of technologies, and the investing in permanent education are needed. The evaluative framework built can be used by the sexual and reproductive health program services and management in primary health care, thereby contributing to their actions.
Confirmation of diagnosis in Romanian children with DFNB1 related hearing loss

Field: Medicine (Health Sciences)

DFNB1 locus has been linked to a nonsyndromic “invisible disability” called congenital sensorineural hearing loss and deafness. Mutations of GJB2 and GJB6 genes are associated with deafness at the DFNB1 locus. The diagnosis of DFNB1 is made with molecular genetic testing. DNA-based testing can be used both prenatally and postnatally. Purpose: to get evidence for implementation of newborn hearing screening programs at national level; to use the molecular testing of children at risk for confirmation of diagnosis and early intervention. OAEs and ABR were performed for 4303 newborns. Audiologic evaluation of 38 children suspected of having hearing loss was performed too. Physical examinations and family history were used to get information about congenital deafness. DNA from blood samples was isolated, and two PCR multiplex assays were developed to detect DFNB1 mutations. Only 23 newborns were screened positive. Newborns were referred to audiologic evaluation, genetic counseling and testing for the etiologic diagnosis. Physical examination revealed no other abnormal findings. GJB2 mutations were detected in 36.03% of patients, and all of them have 35delG mutation. None of them was found to have GJB6 mutations. Our results suggested that molecular testing was an accurate method of early determining cause of congenital hearing loss and helped us to exclude GJB6 gene from the routine hearing screening protocol.
Management of patients with cirrhosis in the emergency department: Implications for hospitalization outcomes

Field: Medicine (Health Sciences)

1New York Presbyterian Weill Cornell Medical Center New York, New York, USA 2Columbia University Irving Medical Center, New York, New York, USA Abbreviations: AKI, acute kidney injury; AVB, acute variceal bleeding; ED, emergency department; EM, emergency medicine; GI, gastrointestinal; HRS, hepatorenal syndrome; INR, international normalized ratio; LVP, large-volume paracentesis; MAP, mean arterial pressure; PPCD, post-paracentesis circulatory dysfunction; SBP, spontaneous bacterial peritonitis. Correspondence Sandeep Sikerwar, NewYork-Presbyterian Weill Cornell Medical Center, Medicine; NewYork-Presbyterian Columbia University Medical Center, Medicine New York, NY, USA. Email: [email protected]
Preparation of N-aryl-ketonitrone spin traps

Field: Chemistry (Physical Sciences)

Abstract The syntheses of seven N-aryl-C,C-dialkoxycarbonylnitrones 1–7, six of which were original, were achieved from the appropriate aryl-nitroso compounds. These ketonitrones were found to trap efficiently carbon-centred free radicals in aqueous media, yielding stable aminoxyl radicals whose EPR spectra lasted several days. The two penta-deuterated compounds 6 and 7 were also found to be efficient at trapping methoxyl radical. Their various spin adducts showed simple three line signals, very sensitive to the polarity of the environment. This study represents the very first use of linear ketonitrones as spin traps.