jimnoneill/paper-to-field-training huggingface dataset:
Data from Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

<div>Abstract<p>Despite treatment with intensive chemotherapy, acute myelogenous leukemia (AML) remains an aggressive malignancy with a dismal outcome in most patients. We found that AML cells exhibit an unusually rapid accumulation of the repressive histone mark H3K27me3 on nascent DNA. In cell lines, primary cells and xenograft mouse models, inhibition of the H3K27 histone methyltransferase EZH2 to decondense the H3K27me3-marked chromatin of AML cells enhanced chromatin accessibility and chemotherapy-induced DNA damage, apoptosis, and leukemia suppression. These effects were further promoted when chromatin decondensation of AML cells was induced upon S-phase entry after release from a transient G<sub>1</sub> arrest mediated by CDK4/6 inhibition. In the <i>p53</i>-null KG-1 and THP-1 AML cell lines, EZH2 inhibitor and doxorubicin cotreatment induced transcriptional reprogramming that was, in part, dependent on derepression of H3K27me3-marked gene promoters and led to increased expression of cell death–promoting and growth-inhibitory genes.</p><p>In conclusion, decondensing H3K27me3-marked chromatin by EZH2 inhibition represents a promising approach to improve the efficacy of DNA-damaging cytotoxic agents in patients with AML. This strategy might allow for a lowering of chemotherapy doses, with a consequent reduction of treatment-related side effects in elderly patients with AML or those with significant comorbidities.</p>Significance:<p>Pharmacological inhibition of EZH2 renders DNA of AML cells more accessible to cytotoxic agents, facilitating leukemia suppression with reduced doses of chemotherapy.</p><p><i>See related commentary by Adema and Colla, p. 359</i></p></div>
Research on the Application of Artificial Intelligence Technology in Power System Intelligent Dispatching Automation

Field: Engineering (Physical Sciences)

Abstract From the perspective of meeting the power quality requirements of users, the article analyses the characteristics of traditional voltage and reactive power control mode and the regional power grid reactive voltage optimization centralized closed-loop control mode (AVC system) based on the dispatch automation system (SCADA/EMS) from the perspective of technical management. Combining the reactive power/voltage real-time optimization control model, a real-time optimization control method of the regional power grid based on the improved differential evolution algorithm is proposed. The particle swarm algorithm is combined with the characteristics of reactive power/voltage control to improve the initial particle quality, reduce the optimization space, and introduce a crossover operator to improve the calculation speed and efficiency of the algorithm. Taking an actual regional power grid as an example, the simulation calculation of reactive power/voltage real-time optimization is carried out. The results show that the proposed algorithm and control strategy are feasible and effective.
Two autopsy cases of Epstein-Barr virus infected T-cell lymphoma preseting as hemophagocytic syndrome.

Field: Medicine (Health Sciences)

Here we report two cases of Epstein-Barr virus related T-cell lymphomas manifested primarily as hemophagocytic syndrome. In case 1, although acute non-A non-B hepatitis with DIC was suspected, bone marrow aspiration was interpreted to be compatible with T cell malignancy. Autopsy revealed a widespread T cell lymphoma with prominent hemophagocytosis by macrophages. The second case was diagnosed as malignant histiocytosis on clinical symptoms and bone marrow findings. Lymph node biopsy was reported as diffuse lage cell lymphoma of T cell origin with reactive macrophages, which was confirmed at autopsy.In both cases, approximately one in each twenty neoplastic cells contained EB virus genomes as revealed by in situ hybridization. HPS in these cases might be explained by reactivation of lymphoma related EB virus. Macrophages should be activated by both viruses and lymphokines which were produced by tumor cells.
Histoplasmosis in Rio Grande do Sul, Brazil: a 21-year experience

Field: Medicine (Health Sciences)

Of 156 cases of histoplasmosis observed in the State of Rio Grande do Sul (Brazil), during a 21-year period (1978-1999) 137 were included in this study. Sixty-seven per cent of the patients had hematogeneous disseminated histoplasmosis, 24% had a self-limited syndrome (acute pulmonary histoplasmosis, histoplasmoma or primary pulmonary lymph node complex), and 9 per cent had chronic pulmonary histoplasmosis. Clinical, mycological, and epidemiological data were reviewed and commented.
Dual B and T markers on lymphocytes in fulminant nodular lymphoma.

Field: Medicine (Health Sciences)

Dual B and T markers on lymphocytes in fulminant nodular lymphomaMost lymphomas and leukaemias may be classified according to whether the malignant cells are derived from thymus (T lympho- cytes) or bone marrow (B lymphocytes).In a few cases the cells may carry markers of both types,1-4 which may indicate a proliferation of the small population of lymphocytes with dual markers present in normal people.5We report such a case in a patient with fulminant lymphocytic lymphoma, in which a sequential study of B and T markers was made.
Effects of Stage of Maturity on P and S Critical Levels in Subterranean Clover1

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Subterranean clover is widely used for pastures in western Oregon; however, little information is available on the effects of stage of maturity on P and S critical levels. The response to P and S fertilization, nutrient contents at different sampling dates, and total yields at harvest were evaluated at two locations in Oregon. The soil at one location is mapped as a complex of Oakland and Nonpareil series, which are well‐drained, hillslope soils developed from sedimentary rock. The soil at the second location is a Veneta silt loam, a moderately well‐drained soil formed from old mixed alluvium. On both sites, the P concentration of the mixed grass and clover forage at harvest was higher in plants that had received P fertilization (0.20%) than in plants that had not (0.14%). The concentration of P in the clover component remained relatively stable from mid‐March to mid‐April in both fertilized and unfertilized treatments. The critical level of P for subterranean clover leaflets and petioles collected between mid‐March and mid‐April was approximately 0.25% P. Sulfur fertilization increased yield 45% and more than doubled S concentration of mixed forage. Added S increased S concentrations in the clover at every sampling date. Sulfur concentrations were relatively constant from mid March to mid‐April, and approximately 0.20% S was identified as the critical level for clover samples collected during this time.
The quantitation of tubulin in neuroblastoma cells by radioimmunoassay.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The amount of tubulin in a clone of neuroblastoma cells (Nb2a-AB-1) which undergoes microtubule-dependent neurite elongation has been determined. This clone undergoes shape differentiation without cessation of cell division, and both differentiated and nondifferentiated cells have the same cell cycle parameters. To quantitate tubulin pools, a radioimmunoassay was developed with a rabbit serum raised to sodium dodecyl sulfate-treated Tetrahymena axonemal tubulin. Using purified hog brain tubulin as labeled tracer and competitor, competition curves covering the range of 0.1 to 100 microgram/ml were obtained. Curves obtained using purified mouse brain or neuroblastoma tubulin as competitors were similar to those obtained with hog brain tubulin. The levels of competition obtained with hog tubulin, partially purified tubulin, or fixed microtubules were identical, indicating that the polymerization state of tubulin had no effect on measurements. Postmitochondrial supernatants derived either from cells grown in suspension culture (rounded morphology) or monolayer culture (neurite-bearing morphology) contained equivalent amounts of tubulin (3.6 +/- 0.5 pg/cell and 3.1 +/- 0.2 pg/cell, respectively); tubulin constituted 2.7% of the postmitochondrial supernatant protein in either cell type. These data indicated that cells utilizing microtubules primarily for mitosis or for cytoskeletal functions and mitosis show no net change in the total soluble tubulin pool.
2. Regularity: causation without connection?

Field: Arts and Humanities (Social Sciences)

A regularity is where one kind of thing is associated with or followed by another kind of thing. ‘Regularity: causation without connection?’ shows that types of events, actions, or states seem to come in pairs where if we have the first, we have the second. Why do we have these regular associations of types of event? It is because the first type of event is a cause of the second. But do we have good grounds to say this? Does causation explain regularity? David Hume's constant conjunction account, repetition, causes, coincidences, and regularity theory are all discussed.
Preliminary Results of Methotrexate, Etoposide and Cisplatin in the Treatment of Urothelial Cancer

Field: Medicine (Health Sciences)

Thirty-seven patients with urothelial cancer were given combination chemotherapy with methotrexate, etoposide and cisplatin. Thirty patients were evaluated for response. Response rates were 50% in the primary organ, 50% in the lymph nodes, 0% in lung and bone lesions. Two patients (7%) had a complete response and 12 (40%) had a partial response, for an overall response rate of 47%. The overall response rate rose to 57% in 7 patients treated with escalated doses of methotrexate and cisplatin. The median durations of response were 14 months for complete responders and 16 months for partial responders. Of the 30 evaluable patients, 16 (53%) are alive at a median survival of 30 months. The toxicity of the present regimen was acceptable. The methotrexate-etoposide-cisplatin combination chemotherapy seems to be an effective and safe regimen for urothelial cancer.
Using social media photos to identify tourism preferences in smart tourism destination

Field: Computer Science (Physical Sciences)

Tourism and Travel sector are improving services through the use of a large amount of data gathered from different sources. The ease access to reviews, rating and experiences from different tourists made the touristic planning rich and complex. Hence, a big challenge faced by tourism sector is to use the gathered data for detecting tourist preferences. In this work, we proposed a solution able to detecting tourist implicit preferences based on photos. We used emerging techniques such as Convolutional Neural Network and fuzzy logic to classify tourists in five categories. Finally, a set of photos were analyzed and the results reached over 82% on accuracy metric for all classifiers.
Judgments of interpersonal warmth predict class-based voting preferences

Field: Psychology (Social Sciences)

The present research examined how social class groups shape patterns of political participation. Drawing on research linking lower-class individuals to heightened attunement to others’ needs and behavior, we predicted that lower-class individuals would be more sensitive to different types of warm messages, modulating their trust and voting behavior more acutely to these messages than upper-class individuals. In Experiment 1, lower-class participants showed reduced trust and voting preferences for a candidate depicted as warm by common political tropes relative to upper-class participants, while no class differences were found for the candidate depicted as competent or hostile to an opponent. In Experiment 2, lower-class participants reported greater trust and support for a political figure described as warm by a lower-class member than upper-class participants, but no class difference was observed when the description was by an upper-class member. These findings have implications for cross-class communication with political elites and basic person perception.
Quality of life assessment and cost‑utility analysis of initial chemotherapy for patients with non‑Hodgkin's lymphoma: A prospective analysis

Field: Medicine (Health Sciences)

Chemotherapy has helped prolong survival in patients with malignant lymphoma, enhancing their quality of life (QOL). Despite the eventual decline in the QOL of patients, the impact of initial chemotherapy remains poorly understood. A prospective patient-reported QOL survey among patients with malignant lymphoma receiving initial chemotherapy was conducted, targeting those treated at Gifu Municipal Hospital (Gifu, Japan) between January 2021 and December 2022. Surveys were conducted pre- and post-chemotherapy based on the EuroQol 5 dimensions. Drug costs were calculated using official prices and analyzed from the cost payer's perspective via cost-utility analysis. Among the 60 patients included in the present study, 28 had diffuse large B-cell lymphoma. Cyclophosphamide, doxorubicin, vincristine, prednisolone ± rituximab therapy was the most common treatment (38 patients) and demonstrated superior cost-effectiveness due to its lowest cost and change in utility value. Initial chemotherapy for patients with malignant lymphoma generally improved the QOL. Clinical trial registration: UMIN000042868 (registered on December 28, 2020).
Effect of Acoustic Intensity on Plate Polymeric Membrane

Field: Engineering (Physical Sciences)

The actual acoustic intensity (I) that reaches membrane is measured by ultrasonic power measuring meter. I is altered by changing the height of membrane (H), the nominal ultrasonic power, or ultrasonic frequency in ultrasonic cleaner. The evolution of the property of polymeric membrane exposed to ultrasonic irradiation is followed by the calculation of membrane damage factor (R). Effect of acoustic intensity on the extent of membrane damage is investigated. The results show that the polytetrafluoroethylene (PTFE) membrane is comparatively resistant under ultrasonic irradiation, the polypropylene (PP) membrane is less resistant, but the nylon 6 (N6) membrane can be damaged seriously by ultrasound. When ultrasonic frequency is 45 kHz, I decreases from 1.04 W•cm-2 to 0.10 W•cm-2 as H rises from 3 cm to 9 cm; I increases from 1.04 W•cm-2 to 1.33 W•cm-2 as the nominal ultrasonic power rises from 200 W to 400 W, and R increases as I rises. When the nominal ultrasonic power is 200 W, I rises from 1.04 W•cm-2 to 1.45 W•cm-2 as ultrasonic frequency increases from 45 kHz to 100 kHz, but R generally remains stable when ultrasonic frequencies are 80 kHz and 100 kHz. Membranes are resistant under ultrasonic irradiation when ultrasonic frequencies are 80 kHz and 100 kHz.
Corticosteroid Responses to Milieu Therapy of Chronic Schizophrenics

Field: Medicine (Health Sciences)

OVER the past two decades, it has been well established in both animals and man that emotional distress can stimulate adrenal cortical activity through neuroendocrine pathways. In man, however, emotional distress is regarded as being closely regulated by ego defenses (in a manner perhaps analogous to a buffer system). It appears useful, then, to study both the dimensions of affect state and ego defensive functions as a system, in psychoendocrine investigations in man. This paper will report on corticosteroid excretion in four chronic schizophrenic men during a year's course of intensive milieu therapy. Changes in affect state and in corticosteroid excretion will be related to alterations in the psychosocial equilibrium maintained by these chronic patients. The present study grows out of previous work by Sachar et al1,3,4which described changes in corticosteroid excretion in acutely schizophrenic men as they moved through clinical phases in their
Quantum Chemical Study of Some Benzimidazole and its Derivatives as Corrosion Inhibitors of Steel in HCl Solution

Field: Chemistry (Physical Sciences)

The relationships between corrosion inhibition performance of three kinds of benzimidazole inhibitors compounds and their molecular electronic properties have been investigated using quantum chemistry method. Quantum parameters such as highest occupied molecular orbital (HOMO), lowest unoccupied molecular orbital (LUMO), energy gap between HOMO & LUMO and Mulliken charges have been calculated at the level of DFT/B3LYP with various basic sets 6-31+G(d), 6-31+G(d,p) and 6- 311+G(d,p). Quantum calculation results were discussed by using linear regression analysis method which found inhibition efficiency had a good linear relationship with HOMO energy, energy gap and total charge of substituent group R3. Among three basic sets, 6-311+G(d,p) can provide more accurate calculation results. It was found the theoretical data were well accorded with reported experimental results. Finally, the study may be helpful to design and discover some new homologous inhibitors with good performance.
The Effects of the Natriuretic Factor from Uremic Urine on Sodium Transport, Water and Electrolyte Content, and Pyruvate Oxidation by the Isolated Toad Bladder

Field: Medicine (Health Sciences)

The urine of patients with chronic uremia contains a gel filtration fraction that is natriuretic in the rat. The effects of this fraction on the isolated urinary bladder of the toad were examined in the present studies. When added to the serosal surface of the bladder, a significant and substantial fall in short-circuit current and potential difference was observed. The changes began after a lag period of at least 10 min and continued over a period of 60 min. The decrease in short-circuit current at the end of 1 h averaged 44%. The same fraction from the urine of normal subjects produced no significant change in either short-circuit current or potential difference. When the isolated epithelial cells from the toad bladder were incubated in the presence of the inhibitor, intracellular sodium content increased significantly. There was no change in intracellular water content; hence the intracellular concentration of sodium increased by a mean of 7 meq/liter. The changes in intracellular potassium content and concentration were not satistically significant. When the isolated epithelia were incubated with the uremic factor, there was also a significant decrease in pyruvate utilization in relation to cells from paired hemibladders incubated in the absence of the fraction. The fraction from normal subjects produced no change in either intracellular sodium content or pyruvate oxidation. The results suggest that the inhibitor acts from the serosal surface, inhibits sodium transport across the serosal barrier, and produces a decrease in substrate utilization in association with the change in transepithelial sodium transport.
Transformative teaching and learning in further education: pedagogies of hope and social justice Transformative teaching and learning in further education: pedagogies of hope and social justice , by Rob Smith and Vicky Duckworth, (£26.99) 2022, Bristol, policy press, 209 pp., ISBN: 978-1-4473-6233-3

Field: Social Sciences (Social Sciences)

"Transformative teaching and learning in further education: pedagogies of hope and social justice." Journal of Education Policy, ahead-of-print(ahead-of-print), pp. 1–2 Disclosure statementNo potential conflict of interest was reported by the author(s).
LEVELS OF POLYCYCLIC AROMATIC HYDROCARBONS IN SOME COAL TAR SKIN PREPARATIONS

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Seven coal tar-containing skin preparations available in New Zealand have been analysed for several polycyclic aromatic hydrocarbons (PAHs) by a gas chromatographic method. All the preparations were found to contain PAHs that have been shown to be carcinogenic to animals. A notable feature of the results was the considerable range in concentrations of these compounds. Levels of benzo(a)pyrene were found to vary from 1 to 360 mg/kg.
A comprehensive review of the mental spine

Field: Dentistry (Health Sciences)

Clinical case reports and research regarding the mental spines and their associated structures create a detailed picture of the floor of the mouth for assessment during clinical treatment. This compilation of information covers the mental spines, the attached geniohyoid and genioglossus muscles, the lingual foramina, and the veins and arteries of the jaw and floor of the mouth. It is important to consider the variations in the mental spines for oral and maxillofacial treatment involving the mandible. Differences in anatomy of the mental spine, including their number, location, and size, can impact diagnosis and treatment approaches.
Inferring Human Activity Using Wearable Sensors

Field: Computer Science (Physical Sciences)

This paper presents methods that use data from wearable sensors, such as those found in low-cost commodity hardware, to infer the human activity (such as reading or walking) corresponding to the sensor readings. A related task is the identification of individuals based on the same data. The classification accuracy of the methods used in this work is higher than earlier work using the same dataset. Further, a significant reduction in the number of sensor data streams produces only a very small impact on this accuracy, which is a feature of practical significance due to implications for network bandwidth and energy budgets in such systems.
Measurement of the electron beam energy in a source with a plasma anode and the beam extraction into the atmosphere through a foil window

Field: Physics and Astronomy (Physical Sciences)

Abstract Measurements of the energy of an electron beam in an electron beam source with an explosive-emission cathode, a plasma anode and a foil window, providing the extraction of an electron beam with a cross-section of (100–200) cm 2 into the atmosphere, have been performed. The high voltage source was a Marx generator based long lines with matched loads. The energy values were calculated from the results of measurements of the temperature of a beam collector placed in vacuum using thermistors and an infrared imager. At an accelerating voltage of ~ 200 kV, a current of (1–2) kA, and an electron beam duration of 5 μs, the maximum values of the energy released in the collector with a cross section of 74 cm 2 were (650–850) J/pulse. A decrease in the current and energy of the beam was recorded approximately by a factor of two after passing through an AMG-2n aluminum-magnesium foil with a thickness of 30 μm. The use of infrared imager for recording the beam structure in the plane of the output window in air has been tested.
Rehoming of adopted children : current legislation and implications for practice

Field: Social Sciences (Social Sciences)

In 2013, an investigative report by Reuters uncovered a startling practice now known as private adoption rehoming, also sometimes referred to as rehoming or unregulated custody transfer adopted of children. This practice involves adoptive parents seeking new families for their adopted children without the help or involvement of adoption professionals. Because these new families are not vetted (no background checks, home studies, etc.), the practice can result with children ending up in unsafe and potentially abusive homes. While some states have taken measures to address this problem, many have not. Even in those states who have passed rehoming legislation, the majority are punitive not preventative, meaning adopted children are still at risk of being rehomed. This paper provides an overview of the practice of rehoming and the status of legislation regarding the practice. Profiles of each state present information that is important to understand and consider when making decisions about rehoming legislation. Implications for practice and general policy recommendations are presented.