jimnoneill/paper-to-field-training huggingface dataset:
Impact of SWI/SNF deficiency in TGF-β signaling in lung cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

SWI/SNF is a family of chromatin remodeling complexes that uses the energy provided by ATP hydrolysis to modify the level of chromatin compaction regulating processes such as gene expression or DNA damage repair. Large cancer sequencing studies have provided evidence of SWI/SNF disruption in 20% of cancer patients, which suggest a tumoral suppressor role of these complexes. However, the molecular mechanisms underlying its role in tumorigenesis remain largely unknown. Lung cancer remains the main cause of cancer-related deaths worldwide with a mean survival rate below 20% despite the new development of targeted or immunotherapies. Consequently, any new knowledge about the molecular mechanisms involved in lung cancer and its potential implication in therapy is a topic of great interest. Morphological changes observed in SWI/SNF-deficient cells made us hypothesize that TGF-β pathway might be affected in these cells due to its function in epithelial-mesenchymal transition (EMT). Here, we analyze the molecular effect of the depletion of a SWI/SNF subunit (ARID2) in several lung cancer cell lines with different mutational backgrounds. Our results suggest that we efficiently produced ARID2 depletion in our cell models using siRNAs. This depletion is accompanied with an alteration of TFG-β pathway evidenced by downregulation of its receptor (TGFBRII). Moreover, this downregulation is not the result of an overactivation of TGF-β signaling, nor by the upregulation of the negative regulator SMAD7; which suggest that SWI/SNF might directly regulate TFGBRII expression. Finally, we have characterized, at the transcriptional level, the response of SWI/SNF deficient cells to TFG-β induction.
TRAFFIC, KILLER NUMBER ONE. AN OVERVIEW OF THE HAZARD OF YOUNG MOTORISED ROAD USERS

Field: Social Sciences (Social Sciences)

This report considers the road hazard to which 16 to 24 year-olds are exposed, classified according to the manner of traffic participation. It appears that 10% of all traffic fatalities are 18 to 25 year-old drivers. The fatality risk for moped riders is greater than for any other transport mode: about three times greater than that for cyclists and even ten times greater than that for drivers. 40% of all registered motorcycle victims is 18 to 25 years old. Virtually no road accident victims are found among drivers of lorries and buses. In this category, the collision partner tends to be the victim. The report also considers the possible causes of road hazard per road user category. An approach to the problem is proposed. In general, the behaviour of youth in traffic can be typified as follows: (1) lack of driving experience; (2) insufficient recognition of danger; (3) greater mental effort needed to drive a vehicle; (4) likely to make errors in complex situations; (5) overestimation of their own liability; and (6) a greater willingness to take risks.
A study on the application of optimization algorithms in vocal music teaching strategies

Field: Computer Science (Physical Sciences)

Abstract Subjective interference is a common difficulty in vocal music teaching, and human ear audition cannot fully objectively analyze the students’ problems in vocal practice due to the influence of environment and other factors. This paper takes the convolutional neural network as the vocal music recognition algorithm and the Mel spectrum as the vocal music feature extraction algorithm and constructs the vocal music analysis model based on the optimization and improvement of the two algorithms. Then select the support vector machine, the nearest neighbor node, Wavenet, LSTM, GAN, SAGAN, CLDNN_BILSTM, and other models, as well as this paper’s model, for comparison experiments. Finally, the model was utilized in the vocal education classroom to evaluate the singing practice of four students. It is found that the MSE value of Arousal’s algorithm in this paper is the lowest, and the R 2 values of 0.51197 and 0.71058 are the highest in the test of the MFCC vocal music feature dataset. Valence’s model in this paper has the MSE value of 0.51996, which is still the lowest, and the R² value of 0.76946, which is still the highest. This paper’s model has the best performance and results. The average rate of professional singers is 61 beats, and the model calculates the average singing rate of the four students as 77, 66, 63, and 61 beats. The first three still have a large gap compared to the standard level, and the student D level is higher. The problem of student practice analysis and vocal feature extraction and recognition in vocal teaching can be solved using new ideas and methods provided in this study.
Synthesis of Alginate-Curcumin Nanocomposite and Its Protective Role in TransgenicDrosophilaModel of Parkinson’s Disease

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The genetic models in Drosophila provide a platform to understand the mechanism associated with degenerative diseases. The model for Parkinson's disease (PD) based on normal human alpha-synuclein ( α S) expression was used in the present study. The aggregation of α S in brain leads to the formation of Lewy bodies and selective loss of dopaminergic neurons due to oxidative stress. Polyphenols generally have the reduced oral bioavailability, increased metabolic turnover, and lower permeability through the blood brain barrier. In the present study, the effect of synthesized alginate-curcumin nanocomposite was studied on the climbing ability of the PD model flies, lipid peroxidation, and apoptosis in the brain of PD model flies. The alginate-curcumin nanocomposite at final doses of 10 −5 , 10 −3 , and 10 −1 g/mL was supplemented with diet, and the flies were allowed to feed for 24 days. A significant dose-dependent delay in the loss of climbing ability and reduction in the oxidative stress and apoptosis in the brain of PD model flies were observed. The results suggest that alginate-curcumin nanocomposite is potent in delaying the climbing disability of PD model flies and also reduced the oxidative stress as well as apoptosis in the brain of PD model flies.
Destination Branding Strategy in Hexa-Helix Model: Case Study on Ciletuh-Pelabuhanratu Geopark Tourism Destinations in Maintaining Unesco's Assessment

Field: Social Sciences (Social Sciences)

This study discusses the efforts of Hexa-Helix actors in forming a destination branding strategy at the Ciletuh-Palabuhanratu Geopark tourist destination which is now the Unesco Global Geopark Ciletuh-Palabuhanratu to maintain the assessment from Unesco, one of the validation results is a promotion to increase the number of visitors through communicating the advantages of Geopark Ciletuh-Palabuhanratu which consists of three elements of harmony, namely Biodiversity, Geodiveristy and Culturdiversity. Researchers identify the role of each Hexa-Helix actor based on their respective duties, because the helix studied has an important contribution in building the sustainability of the Ciletuh-Palabuhanratu Geopark tourist destination as a Unesco Global Geopark. This research uses a type of qualitative research using a post-postivism paradigm approach and case studies. Data collection techniques used are interviews, observation, literature study and documentation. Hexa-helix actors consisting of academics, business owners, communities, government or governing bodies, media and visitors. Each helix interacts with each other so as to form a communication to improve the construction of facilities, improve services, carry out promotional activities, play a role in every event and hold training for the local community to become part of the development of the economic and social sector.
Alfonso of Jaén, His Life and Works with Critical Editions of the Epistola Solitarii, the Informaciones and the Epistola Serui Christi

Field: Arts and Humanities (Social Sciences)

The Spaniard Alfonso, Bishop of Jaén, was commissioned by St. Bridget of Sweden to prepare an edition of her Revelationes (the Liber Celestis). The present book gives an account of Alfonso's life and critical editions of three writings by him.
Thermo-Hydro-Mechanical Coupled Analysis in Low Permeability Media Under Nuclear Repository Conditions

Field: Earth and Planetary Sciences (Physical Sciences)

The design of underground repositories to storage high level radioactive waste is based on the multi barrier concept that consists of placing natural and artificial barriers around the radioactive material for isolation. The artificial barrier is commonly made of expansive clay (e.g. bentonite) that is subjected to heating and hydration resulting in Thermo-Hydro-Mechanical (THM) coupled phenomena. Experimental evidence has shown an important reduction in the hydration rate of the clay at advanced stages of infiltration tests under non-isothermal conditions. Traditional models have had problems to properly reproduce the hydraulic behavior observed in some experiments, overestimating the hydration rate and underestimating the time required to reach fully saturation conditions. \n\nThis thesis presents THM modeling of the FEBEX bentonite based on a mathematical framework suitable for problems in low permeability media. In addition, phenomena not included in traditional models like the threshold hydraulic gradient, thermo-osmosis and double structure are incorporated in the proposed framework to explain the reduction in the hydration rate. \n\nIn order to assess the performance of the models, infiltration laboratory tests performed under isothermal and non isothermal conditions and the mock-up large scale test carried out by CIEMAT, are presented. Additionally, a synthetic in-situ exercise sponsored by the eFEBEX project to study the THM evolution of a full scale bentonite buffer under typical repository conditions is also discussed. All numerical simulations were carried out with the finite element program CODE_BRIGHT and divided into four cases: a reference case, (based on the standard THM formulation) and the other three correspond to advance model incorporating the following phenomena: the threshold hydraulic gradient, thermo-osmosis and double structure effects. \n\nThe models incorporated in the existing THM formulation enable the improvement of numerical predictions of the experimental data obtained from the infiltration tests and mock-up experiment by reproducing the reduction in the hydration rate inside the bentonite. It has been observed that the double structure model that considers the two dominant pore levels and material fabric changes in the FEBEX bentonite provided a more satisfactory reproduction of the long-term experimental results.
Description of Rare Genetic Variants Discovered with Promega PowerPlex® Forensic Amplification Kits during STR analysis of Routine Paternity and Kinship Cases

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Short Tandem Repeats (STR) have been widely used to create a discriminating DNA profile during the forensic investigation of a crime. The Paternity and Kinship Division at Medico-legal Directorate (MLD)/ Baghdad, provides a DNA fingerprinting service for paternity and kinship requests from different courts of law and police departments from across the country. Several rare variants were observed during DNA analysis such as rare off-ladder alleles, tri-allelic pattern as well as allele dropout. Variants that have been transmitted among family members were investigated in this study. During the period between 2008 to 2019, 38309 samples have been analyzed in the Paternity and Kinship Laboratories for DNA profiling to resolve the referred cases. DNA profiles found to have unusual STR patterns (off-ladder, tri-allelic pattern, inter-loci variable were analyzed and documented). A total of 17 variants were observed which were as shared among family members. Rare off-ladder alleles (9 cases + inter-loci variant 2 cases), as well as 6 cases of tri-allelic patterns were recorded. The presence of each type of these variants among family members proves that these variations are of genetic origin. They also represent rare genetic variants specific to the Iraqi populations that could be used for the establishment of a new Iraqi DNA database, which might be useful for genealogical studies as well as in terms of resolving familial, social, and moral disputes.
Estimating the Time of Arrival of a Shipment with Machine Learning

Field: Computer Science (Physical Sciences)

Effectively estimating the arrival day of a shipment is an important capability for an express courier company to ensure both customer satisfaction and internal operations efficiency. This paper studies predicting the estimated time of arrival (ETA) of a package, shortly denoted by PETAP, under a collaboration with an industrial partner. Our approach employs machine learning (ML) techniques: CatBoost, multi-layer perceptrons (MLPs) with categorical embeddings, and Transformer neural networks, to predict delivery dates based on shipment locations and status. Challenges such as complex inter-modal networks and high-cardinality categorical features are addressed. Our paper contributes to the literature by formalizing the PETAP problem in the context of express shipping: the proposed models outperform the current business baseline accuracy by more than 25%. In our experimentation with a dataset including millions of data-points we propose a tabular vs sequence to sequence approach observing the superiority of the former. Future research directions include explicit modeling of transportation networks and exploring alternative ML approaches for improved prediction accuracy.
Ageism on the Therapeutic Couch: Aging Attitudes and Late-Life Psychotherapy

Field: Psychology (Social Sciences)

Abstract Ageist stereotypes characterize older adults as depressed, demented, and dependent. A large body of research has documented the adverse physical and emotional impact of ageism on older adults. Mental health professionals, however, often see the minority of older adults who, in fact, are depressed, have cognitive impairments, and/or are increasingly dependent on others. To what degree do pre-existing attitudes about aging come into play in psychotherapy with older people? With all age groups, psychotherapists often help clients better understand and challenge longstanding negative assumptions about self and world (sometimes called “the unconscious” or “underlying schemas”). These assumptions often impede the individual’s ability to successfully contend with life problems. This presentation will discuss ways in which psychotherapists can assist older clients in clarifying their underlying (and often self-limiting) negative assumptions about aging, moving beyond them to better contend with late life stressors, and improving emotional well-being.
Movement Control of Accompanying Robot Based on Artificial Potential Field Adapted to Dynamic Environments

Field: Computer Science (Physical Sciences)

SUMMARY This paper focuses on mobile robots that can accompany a person, that is, it addresses how to control the position of the robot relative to the accompanied person according to the dynamic environment. The robot is expected to move side by side with the person in a normal situation, but a position in front or behind the person might be better if there are obstacles. The shape of the artificial potential field of the accompanied person is devised to smoothly control the robot position in a unified way. The Laplace potential method is also used subsidiarily to cope with extremely cluttered environments. Simulations and experiments in real space show the usefulness of the proposed method.
THE SYNERGISTIC EFFECT OF CD59 AND CD3 IN T CELL ACTIVATION SIGNALS TRANSDUCTION

Field: Immunology and Microbiology (Life Sciences)

Objective To study the synergistic effect of CD59 and CD3 in T cell activation signal transduction,and further explore the mechanism concerning CD59 transmitting signals to T cell. MethodsThe eukaryotic expression vector containing CD3ζRNAi and CD59RNAi was identified by enzyme digestion and transfected into Jurkat cells by liposome,while steady cells cloned could get through G418 screening.CD59 and CD3ζ mRNA level were detected by RT-PCR.The cell proliferation activity was measured by MTT colorimetry after anti-CD3 mAb and anti-CD59 mAb.The phosphorylation levels of ZAP-70 protein tyrosine were investigated by immunoblot analysis,the kinetic changes of in T cell were determined by laser scanning confocal microscope imaging,while interleukin 2(IL-2) in cell supernatants fluid was detected by ELISA. ResultsCD59 and CD3ζ expression was successfully inhibited in transfected with siRNA plasmid group cells.The cell proliferation,phosphorylation levels of ZAP-70,degree of and IL-2 in transfected siRNA plasmid group cells were decreased compared with non-transfected and Jurkat cells after anti-CD3 mAb and anti-CD59 mAb,the differences were statistically significant(F=96.13-328.60,q=6.27-32.664,P0.01). ConclusionThere is a synergistic effect of CD59 and CD3 in T cell activation signal transduction.
Nostalgia of the Beginnings

Field: Arts and Humanities (Social Sciences)

Henry David’s Thoreau book Walden recreates in a literary form the period that the author spent in the woods near Walden Pond. Being a transcendentalist influenced by Emerson’s philosophy, Thoreau reiterates the essential role that nature has in the spiritual and moral development of man. In Walden the author describes a return to a primordial age in which man lived in a state of wonder before the beauty of the universe and in a permanent communion with it. The sacredness of nature is rendered through ritual gestures that accompany man on his road to revelation. Thus, the period of time spent by Thoreau near Walden Pond acquires the qualities of an initiation during which man rediscovers his self and undergoes a spiritual awakening.
IMPACT OF ADOLESCENT TRAUMA ON SENSE OF PURPOSE IN MIDDLE-TO-LATE ADULTHOOD

Field: Psychology (Social Sciences)

Previous research has found that early experiences can uniquely impact later in life outcomes. However, work is needed to understand how different forms of adolescent adversity influence later purpose development. This research evaluates the impact of different kinds of adolescent trauma on later adulthood sense of purpose. Trauma and sense of purpose were assessed using the Brief Betrayal Trauma Survey (Goldberg & Freyd, 2006) the Life Engagement Test (Scheier et al., 2006) respectively. Existing data comes from the Hawaii Longitudinal Study of Personality and Health. Participants (n = 545) retrospectively reported three kinds of trauma during adolescence: 1) non-betrayal trauma, such as a natural disaster; 2) low betrayal trauma, such as being abused by a stranger; and 3) high betrayal trauma, such as being abused by a relative. Approximately 10–15 years later, participants (M = 60.15, SD = 1.96) reported their sense of purpose. Pearson correlations were calculated between later adulthood sense of purpose, adolescent trauma types, and composite trauma scores. None of the negative effects of these correlations were significant. However, the effects differed when evaluating the three largest racial groups from the sample: Caucasians, Japanese, and Native Hawaiians. Sense of purpose and adolescent low betrayal trauma (r(222) = -.196, p = .003), high betrayal trauma (r(222) = -.139, p = .038), and composite trauma scores (r(222) = -.214, p = .001) were all significantly related for only the Japanese participants. We will discuss the ways in which early in life experiences differentially impact purpose development across groups.
2732 Signet Ring Cell Carcinoma: A Rare Case Report Masquerading as Digital Infarction

Field: Medicine (Health Sciences)

INTRODUCTION: Signet Ring Cell Carcinoma (SRCC) is a mucin producing adenocarcinoma, commonly seen in the gastrointestinal tract, also rarely in the urinary bladder, pancreas, breast and gallbladder. Tumor embolism due to slowly evolving disseminated intravascular coagulation (DIC) can manifest as digital infarction and this report highlights its presentation in a case of SRCC. CASE DESCRIPTION/METHODS: An 82-year-old African American lady presented with 2 weeks of low back pain, hematuria and purplish discoloration of toes. Physical exam was significant for multiple gangrenous digits but palpable pulses. CT Abdomen and Pelvis revealed diffuse bony metastases and moderate bilateral hydronephrosis. Labs were significant for Hemoglobin of 6.6 gm/dl and Creatinine 1.8. Bone marrow biopsy was consistent with metastatic carcinoma of SRCC. Pathologic staining was positive for AE1/AE3, CK7, CK20, and CDX2, suggestive of gastric tract origin than urinary bladder. Further investigation for the location of the primary tumor was negative. Evaluation for peripheral arterial disease, vasculitis, thrombophilia, and endocarditis for digital infarction was negative. With elevated D-Dimer, prolonged PTT and normal fibrinogen suggestive of slowly evolving DIC, digital infarction from tumor embolism was diagnosed. Ureteral stent placement for hydronephrosis was attempted but was unsuccessful due to multiple clots in the bladder, likely owing to DIC and she further deteriorated to end stage renal disease. Goals of care were discussed with the patient and she was transitioned to hospice care. DISCUSSION: Slowly evolving DIC is seen in cancer (mostly adenocarcinoma), liver disease, aneurysm, hemangioma and rarely sepsis. It’s believed that the destruction and production of coagulation factors/platelets are balanced. Diagnostic labs indicate thrombocytopenia, normal to prolonged PT/PTT, normal to low fibrinogen level and elevated D-Dimer. Heparin is the treatment of choice when bleeding is not suspected. Unfortunately, heparin was contra-indicated in our patient who had hematuria. In conclusion, this case illustrates the aggressive presentation of SRCC, which can present as digital infarction. Identifying tumor embolism and slowly evolving DIC is important as it may indicate poor prognosis. This case is unique in its presentation and cancer should be ruled out in digital infarction when other common causes are not identified.
Measurement-driven reconstruction of many-particle quantum processes by semidefinite programming with application to photosynthetic light harvesting

Field: Physics and Astronomy (Physical Sciences)

Quantum measurements provide a trove of information about a quantum system or process without solution of the Schr\"odnger equation, and in principle, the associated density matrix is a function of these measurements. Inversion of the measurements can produce an estimate of the density matrix, but this estimate may be unphysical, especially when the measurements are noisy or incomplete. We develop a general approach based on semidefinite programming [D. A. Mazziotti, Phys. Rev. Lett. 106, 083001 (2011)] for reconstructing the density matrix from quantum measurements which leads naturally to nonnegative solutions, a critical attribute of physically realistic solutions. We discuss the use of this methodology for reconstructing $p$-particle reduced density matrices ($p$-RDMs) of $N$-particle systems where additional semidefinite constraints, known as $N$-representability conditions, are essential because they ensure that the $p$-RDM represents an $N$-particle system. Special attention is given to the $N$-representability conditions for the experimentally important cases where $p=1$ or 2. We apply the methodology to reconstructing the time-dependent quantum process of exciton transfer in a photosynthetic light-harvesting complex.