jimnoneill/paper-to-field-training huggingface dataset:
Imidazoquinoxaline derivative EAPB0503: A promising drug targeting mutant nucleophosmin 1 in acute myeloid leukemia

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

BACKGROUND Nucleophosmin 1 (NPM1) is a nucleocytoplasmic shuttling protein mainly localized in the nucleolus. NPM1 is frequently mutated in acute myeloid leukemia (AML). NPM1c oligomerizes with wild‐type nucleophosmin 1 (wt‐NPM1), and this leads to its continuous cytoplasmic delocalization and contributes to leukemogenesis. Recent studies have shown that Cytoplasmic NPM1 (NPM1c) degradation leads to growth arrest and apoptosis of NPM1c AML cells and corrects wt‐NPM1 normal nucleolar localization. METHODS AML cells expressing wt‐NPM1 or NPM1c or transfected with wt‐NPM1 or NPM1c as well as wt‐NPM1 and NPM1c AML xenograft mice were used. Cell growth was assessed with trypan blue or a CellTiter 96 proliferation kit. The cell cycle was studied with a propidium iodide (PI) assay. Caspase‐mediated intrinsic apoptosis was assessed with annexin V/PI, the mitochondrial membrane potential, and poly(adenosine diphosphate ribose) polymerase cleavage. The expression of NPM1, p53, phosphorylated p53, and p21 was analyzed via immunoblotting. Localization was performed with confocal microscopy. The leukemia burden was evaluated by flow cytometry with an anti‐human CD45 antibody. RESULTS The imidazoquinoxaline 1‐(3‐methoxyphenyl)‐ N ‐methylimidazo[1,2‐ a ]quinoxalin‐4‐amine (EAPB0503) induced selective proteasome‐mediated degradation of NPM1c, restored wt‐NPM1 nucleolar localization in NPM1c AML cells, and thus yielded selective growth arrest and apoptosis. Introducing NPM1c to cells normally harboring wt‐NPM1 sensitized them to EAPB0503 and led to their growth arrest. Moreover, EAPB0503 selectively reduced the leukemia burden in NPM1c AML xenograft mice. CONCLUSIONS These findings further reinforce the idea of targeting the NPM1c oncoprotein to eradicate leukemic cells and warrant a broader preclinical evaluation and then a clinical evaluation of this promising drug. Cancer 2017;123:1662–1673. © 2017 American Cancer Society .
Evaluation of the emotional answer in HRI on a game situation

Field: Psychology (Social Sciences)

This project has as purpose to propose an adequate method for the assessment of the emotional answer after an interaction with a social and emotional robot. A lottery game application has been developed for playing with the robot Nao, and through an experimental scenario the empathy towards a robot has been demonstrated. As a result, the Emocards are presented as a promising assessment method for the emotional answer of the users.
Bicycle kinetic energy recovery system by using flywheel- a review

Field: Engineering (Physical Sciences)

The Kinetic Energy Recovery System (KERS) is a system for the recovery of braking power energy from the moving vehicles, which is present in the form of residual heat generated during braking.It stores energy and converts it into power, providing power boosts to the vehicle.The KERS system used by the vehicle serves the purpose of saving some of the energy lost during braking, and is more efficient to operate at high temperatures than conventional braking systems.While riding a bike, a lot of kinetic energy is lost during braking.KERS are used to store energy lost during braking using flywheel.Flywheel is used to store and release energy as kinetic energy.Riders can charge the flywheel when they slow down or slope down the mountain and lift the bike as they accelerate or climb the mountain.The proposed design is to simply implement the same concept of using the flywheel as an energy reservoir or energy storage device.However, there are some areas that need to be studied and better results can be achieved by better weight optimization in reducing pedal power.Continuous variable transmission can also be an option to improve transmission efficiency.©2021 ijrei.com.
A Precocious End of Innocence: Re-reading Children's Literature for Today

Field: Arts and Humanities (Social Sciences)

A Precocious End of Innocence: Re-reading Children's Literature for Today (Laura Tosi (ed.), Hearts of Lightness: the Magic of Children's Literature, Venezia, Cafoscarina, 2001, p.197 ISBN88-88613-18-8) by Nicoletta Vallorani
The Role of Nitrilotriacetate in Copper Uptake by Tobacco

Field: Agricultural and Biological Sciences (Life Sciences)

ABSTRACT In growth chamber experiments we studied the effect of nitrilotriacetate (NTA) on Cu uptake by tobacco ( Nicotiana tabacum L.). Plants were exposed for 6 d to 126 μ M Cu and 500 μ M NTA in nutrient solutions without and with 10 g L −1 montmorillonite. Approximately seven times less Cu was dissolved in the montmorillonite solutions than in the nutrient solutions alone. In the absence of NTA, montmorillonite effectively competed with plant roots for Cu, although Cu remained bound to the roots. Nitrilotriacetate increased Cu uptake and translocation into shoots of tobacco by a factor of 3.5 from the nutrient solution and by a factor of 26 from the montmorillonite nutrient solution. Neither growth reduction nor any other visible sign of Cu toxicity was found in the presence of NTA with Cu concentrations of 190 mg kg −1 in the shoots. In the absence of NTA, high Cu concentrations in root samples led to a brownish discoloration of the roots.
How water flow, geometry, and material properties drive plant movements

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Plants are dynamic. They adjust their shape for feeding, defence, and reproduction. Such plant movements are critical for their survival. We present selected examples covering a range of movements from single cell to tissue level and over a range of time scales. We focus on reversible turgor-driven shape changes. Recent insights into the mechanisms of stomata, bladderwort, the waterwheel, and the Venus flytrap are presented. The underlying physical principles (turgor, osmosis, membrane permeability, wall stress, snap buckling, and elastic instability) are highlighted, and advances in our understanding of these processes are summarized.
Comparative Effects of Feed Additives on Broiler Health and Farm Economics under a Controlled Study in Punjab

Field: Agricultural and Biological Sciences (Life Sciences)

Background: Broiler farming plays a vital role in supporting food security and rural livelihoods in India. However, with rising concerns over antibiotic resistance, there is a growing need to explore safer and more sustainable alternatives to antibiotic growth promoters (AGPs). This study examined how selected nutraceutical feed additives influence broiler growth, health and profitability under practical farming conditions in Punjab. Methods: A controlled 42-day trial was conducted with 500 broiler chicks divided into five groups: control (no additive), herbal (1%), nano-zinc (1%), probiotics (0.5%) and enzyme blend (0.3%). Growth performance, serum health markers and economic indicators were recorded. While the biological trial was carried out on 500 birds, the economic evaluation was extrapolated on a standard commercial scale of 1,000 birds to ensure comparability and practical relevance. Data were analyzed to assess differences in productivity and financial returns across treatments. Result: Birds fed with nano-zinc showed the highest body weight gain (2225 g), the better feed conversion ratio (1.67) and good economic profit (`165,100 per 1000 birds). The group fed with nano-zinc also recorded the best benefit-cost ratio (2.62) and lowest break-even cost, indicating significant economic viability. Enzyme- and probiotic-fed groups also performed well, though slightly behind nano-zinc. Improved serum protein levels and lowered liver enzyme values in this group suggested better physiological health and nutrient utilization. In contrast, the control group recorded lowest growth rate and poor returns.
The theologies of transparency in Europe: the limits and possibilities of ‘fusion’ in the EU transparency regime

Field: Social Sciences (Social Sciences)

Abstract The consideration of a transparency regime for the European Union has stimulated considerable response from the Brussels lobbying community. Somewhat predictably, the responses have congregated about two poles: one represented by a strident group of reform activists calling for complete openness with a strong legal component, the other taking a minimalist self‐regulatory approach to the most fundamental issues. The basic positions of the competing sides seem to be immovable; embraced with all the fervour of religious ‘true believers’. At first blush the possibility for a meaningful compromise seems remote. However, the submissions may offer a limited way forward based on a fusion of principles held by many on both sides of the issue. Copyright © 2007 John Wiley & Sons, Ltd.
Time dynamics of electron wave functions of 3d quantum ring in alternating magnetic field

Field: Physics and Astronomy (Physical Sciences)

Three-dimensional axially symmetrical exactly soluble model of quantum ring has been considered in the constant magnetic field. Potential, which restricts particle movement in the system in two directions, has been used. By applying method of splitting into physical processes, an electron wave functions and a quasi-stationary energy levels values have been obtained. Also a qualitative description of wave packet movement has been given for the case of quantum ring threading by alternating magnetic field.
Supplementary Material for: Neoadjuvant pyrotinib plus trastuzumab, docetaxel, and carboplatin in early or locally advanced HER2-positive breast cancer in China: a multicenter, randomized, double-blind, placebo-controlled phase 2 trial

Field: Medicine (Health Sciences)

INTRODUCTION This multicenter, randomized, double-blind, placebo-controlled phase 2 trial compared the efficacy, and safety of adding pyrotinib to trastuzumab, docetaxel, and carboplatin vs placebo, trastuzumab, docetaxel, and carboplatin in Chinese patients with HER2-positive early or locally advanced breast cancer (ClinicalTrials.gov identifier: NCT03756064). METHODS Sixty-nine women with HER2-positive early (T1-3, N0-1, M0) or locally advanced breast cancer (T2-3, N2 or N3, M0; T4, any N, M0) were recruited from Oct 1, 2019, to Jun 1, 2021. Before surgery, patients received 6 cycles of orally pyrotinib (400mg once per day), trastuzumab (8-mg/kg loading dose and 6-mg/kg maintenance doses), docetaxel (75 mg/m2), and carboplatin (AUC=6mg/ml·min) or orally placebo, trastuzumab, and docetaxel, and carboplatin every 3 weeks. The primary end point was independent review committee–assessed total pathologic complete response rate. The 2-sided Cochran-Mantel-Haenszel test, stratified by age, hormone receptor status, tumor stage, nodal status, cTNM stage, and Ki-67 level was used to compare rates between treatment groups. RESULTS In total, 69 female patients were randomized (pyrotinib, 36; and placebo, 33; median age, 53 [31-69] years). In the intention-to-treat population, total pathologic complete response rates were 65.5 % (19/29) in the pyrotinib group and 33.3% (10/30) in the placebo group (difference, 32.2%, p=0.013). Diarrhea was been reported in 86.1% of patients (31/36) in the pyrotinib group as the most common adverse events (AEs), and 15.2% of patients (5/33) in the placebo group. But no grade 4 or 5 AEs were reported. CONCLUSION Treatment with pyrotinib, trastuzumab, docetaxel, and carboplatin resulted in a statistically significant improvement in the total pathologic complete response rate vs placebo, trastuzumab, docetaxel, and carboplatin for the neoadjuvant treatment of HER2-positive early or locally advanced breast cancer in Chinese patients. Safety data were in line with the known pyrotinib safety profile and generally comparable between treatment groups.
Recall, retention, utilisation and acceptability of written health education materials: a pilot study to compare two distribution strategies

Field: Health Professions (Health Sciences)

Objective: To investigate the impact of two distribution strategies (mailout and general\npractitioner(GP)) on the recall of receipt, retention, utilisation and perceived acceptability of\nwritten health education materials.\nDesign: Structured interviews were conducted with randomly selected individuals who had\nreceived written health education materials.\nSetting: Two semi-rural communities in New South Wales, Australia.\nSubjects: 512 people were randomly selected to take part in the study: 212 from general\npractitioners' surgeries and 300 from the electoral register. 55 (10.7%) of these were not\ncontactable. 386 (84.5%) of those contactable consented to the survey.\nInterventions: 300 people received the education materials through the mail in a personallyaddressed\nenvelope. Another 212 received the materials from their general practitioner at the\nend of a routine consultation.\nMain Outcome Measures: Recall of receipt, retention, utilisation and perceived acceptability\nrates 2 weeks after distribution of the materials.\nResults: 77.4% of the mailout group and 90.9% of the GP group recalled receiving the\nmaterials; 75.4% of the mailout group and 93.3% of the GP group reported keeping the booklet;\n66.7% of the mailout group and 56% of the GP group reported reading the booklet. Perceived\nacceptability of the materials was high, with over 80% of respondents finding them very or\nfairly eye-catching, believable, interesting and easy to read.\nConclusion: Although general practitioner distribution led to higher rates of receipt and\nretention, mailout distribution, via the electoral register, led to higher utilisation rates and\nallowed access to a larger proportion of the population, resulting in more individuals having\nbeen exposed to the education message.
ChemInform Abstract: Anellated[1,2,4,5]tetrazines

Field: Chemistry (Physical Sciences)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Wrong Patient

Field: Medicine (Health Sciences)

Letters18 March 2003The Wrong PatientJames G. Gallagher, MDJames G. Gallagher, MDGeisinger Medical Center, Danville, PA 17822-2001 (Gallagher)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-6-200303180-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Chassin and Becher's innovative article (1) emphasizes the importance of paying conscientious and meticulous attention to detail in the management of patients. Without such attention, intelligence is wasted, factual knowledge is worthless, reasoned judgment is impossible, honesty is irrelevant, and compassion is fraudulent (2). Every caregiver knows that in his or her myriad daily interactions with patients there is the possibility for error. All of us hope to meet the challenge of giving excellent care without causing harm, but in the current economic-driven system of health care, speed has replaced attention to detail (3). Quantity is replacing ...References1. Chassin MR, Becher EC. The wrong patient. Ann Intern Med. 2002;136:826-33. [PMID: 12044131] LinkGoogle Scholar2. Gallagher JG. Empiric antimicrobial therapy in the community hospital setting for the cancer patient with fever and neutropenia: the need for vigilance and attention to detail. Recent Results Cancer Res. 1993;132:89-96. [PMID: 8265874] CrossrefMedlineGoogle Scholar3. Connors JM. On talking with a patient. Ann Intern Med. 1984;100:166. LinkGoogle Scholar4. Neuwirth ZE. The silent anguish of the healers. Patients suffer when physicians fall prey to stress. Newsweek. 1999; 13 Sep:79-80. Google Scholar Author, Article, and Disclosure InformationAuthors: James G. Gallagher, MDAffiliations: Geisinger Medical Center, Danville, PA 17822-2001 (Gallagher) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Wrong Patient Mark R. Chassin and Elise C. Becher Are Bad Outcomes from Questionable Clinical Decisions Preventable Medical Errors? A Case of Cascade Iatrogenesis Timothy P. Hofer and Rodney A. Hayward The Wrong Patient Robert M. Wachter , Kaveh G. Shojania , Sanjay Saint , Amy J. Markowitz , and Mark Smith The Wrong Patient Stephen Sandroni The Wrong Patient Linda Fermoyle Rice Metrics 18 March 2003Volume 138, Issue 6Page: 518KeywordsCaregiversEmotionsHealth careHealth care qualityHealth economicsIntelligenceMorbidityMortalityPeer reviewSurgeons ePublished: 18 March 2003 Issue Published: 18 March 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Самовосстановление почвенно-растительного покрова в техногенных ландшафтах юга Приморья

Field: Agricultural and Biological Sciences (Life Sciences)

The processes of gradual natural recovery of vegetation and soil cover on dump breeds of Pavlovsky coal mine was studied. The process of formation of plant communities on the dumps of coal mines passes through a series of successive stages. In the process of development of vegetation cover increases species diversity of plants and common stocks of plant organic matter. In connection with the development of vegetation and its productivity growth in forming soils provides the gradual process of humus accumulation.
Isoform-Specific vs Isoform-Universal Drug Targeting: A New Targeting Paradigm Illustrated by New Anti-ICAM-1 Antibodies

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Drug targeting can be achieved by coupling drugs or their carriers to affinity molecules, mostly antibodies (Abs), which recognize specific protein targets. However, most proteins are not expressed in an exclusive configuration but as various isoforms. Hence, selected targeting molecules may fail to target with enough efficiency in clinical trials, which is overlooked. We illustrate this by targeting ICAM-1, a cell-surface protein overexpressed in many pathologies. Most ICAM-1 targeting studies used Ab R6.5, which binds ICAM-1 domain 2 (D2). Yet, literature and our data show that D2 is frequently absent among ICAM-1 isoforms. We thus produced a battery of five new Abs (B4, B6, B11, C12, G2) and tested their ability to recognize both full-length and -D2 ICAM-1. In solution, all Abs recognized both ICAM-1 forms (from 5.3x1011 to 4.2x1012 sum intensity/well). Coating them on nanocarriers (NCs) rendered G2 specific against -D2 ICAM-1 (4.2x106 NCs/well) while other Abs kept their dual recognition (from 6.4x106 to 2.2x107 NCs/well). All Abs induced NC intracellular uptake in respective cells (from 42% to 85%) and displayed good cross-species reactivity (from 4.4x1011 to 2.6x1012 sum intensity/well). These Abs represent valuable tools to target ICAM-1 and illustrate a new targeting paradigm that may improve classical strategies.
A PRELIMINARY STUDY OF EFFECTS OF ESTRADIOL ON FLANK GLANDS IN RATLIKE HAMSTERS (CRICETULUS TRITON)

Field: Agricultural and Biological Sciences (Life Sciences)

The effects of estradiol on the size and secretion chemistry of flank glands in female ratlike hamsters (Cricetulus triton) were studied. By surgical procedure and hormone replacement, three groups of hamsters being different in reproductive status were formed, which were ovariectomized (OF), intact (IF )and overiectomized plus estradiol capsules females(OEF). From OF to OEF, blood levels of estradiol determined by radioimmunoassay was getting higher ( P 0 01), while the weight, length, width and thickness of flank glands were getting less( P 0 05 or P 0 01)by groups. Gas chromatography was used to measure the differences in flank gland secretions among three groups of hamsters. It was found that there were qualitative and quantitative changes among chemical compounds of flank gland secretions of three groups. Some compounds have a decrease in quantity from OF to OEF, and less and less compounds were detected from OF to OEF. The results evidenced that estradiol can inhibit both size and secretion activity of flank glands.
OBJECTIVE‐SUBJECTIVE ASSESSMENT OF MEAT TENDERNESS

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Compression, shear, adhesion and cooking loss measurements were compared with sensory assessments of tenderness and juiciness. Multiple regression analyses of compression, shear and cooking loss accounted for 83.4% of the total variance in tenderness for samples presented to the panel as 1.5 cm cubes, and 73.2% for those presented as thin strips cut across the fibers. Cooking losses accounted for about 75 % of the variance in juiciness scores. Regression equations indicated that higher cooking losses, and hence decreased juiciness, increased sensory toughness. The relative contribution of compression (connective tissue toughness) and shear (myofibrillar toughness) measurements varied considerably with sample treatment and fiber orientation of samples as presented to the panel.
Towards Effective Safety and Cybersecurity Co-engineering in Critical Domains

Field: Engineering (Physical Sciences)

The primary objective of functional safety and cybersecurity co-engineering is to streamline assessment processes and enhance efficiency by implementing integrated approaches, therefore reducing overall effort and bringing several consequential advantages. Although this concept is not new, and there have already been successful attempts at its utilization in different critical domains such as nuclear, railway, and automotive, no mature approach could be easily adopted and applied during the assessment. Another challenge is that the understanding of co-engineering is essentially different, depending on domain specifics and priorities. Moreover, issues are still related to measuring efficiency achieved by co-engineering utilization. This paper addresses the current state of safety and cybersecurity co-engineering in critical domains. With a focus on nuclear, automotive, and railway domains, it proposes directions toward developing effective co-engineering frameworks for them.
On the Convergence of Absolute Summability for Functions of Bounded Variation in Two Variables

Field: Mathematics (Physical Sciences)

By adopting some new ideas, we obtain the estimates of an absolute convergence for the functions of the bounded variation in two variables. Our results generalize the related results of Humphreys and Bojanic (1999) and Wang and Yu (2003) from one dimension to two dimensions and can be applied to several summability methods.