jimnoneill/paper-to-field-training huggingface dataset:
[A project-class to rediscover school].

Field: Social Sciences (Social Sciences)

In 2006 a project-class was created at the medical and pedagogical centre of Rennes. This centre takes in, for a 5-week period, students aged between 16 and 20 suffering from school refusal. The objective, for the young people overseen by a tutor, is to once again become a player in their educational project to rediscover, in a confidence-building environment, the pleasure of sharing their knowledge with their peers.
[PP.17.13] CORRELATION OF DIAGNOSED PERIPHERAL ARTERY DISEASE WITH AN ABRUPT INCREASE IN ARTERIAL BLOOD PRESSURE DUE TO SUDDEN RENAL ARTERY STENOSIS IN A MIDDLE-AGED WOMAN

Field: Medicine (Health Sciences)

Objective: to establish peripheral artery disease as prognostic marker for renal artery disease. - to relate the sudden onset of hypertension to rapid evolving renal artery stenosis in young patients with limited peripheral artery disease. - to illustrate the necessity of secondary hypertension diagnostic workup in young patients with limited peripheral vascular disease. Design and method: 49-year-old woman with acute occlusion of the distal left popliteal artery was admitted to the surgical clinic of our hospital and treated with intravenous analgesics and prostaglandins. On the third day of hospitalization, she presents with high blood pressure (200/100mmHg) and sinus tachycardia. Laboratory testing revealed normal renal function(electrolytes and urinary albumin excretion), normal lipid levels. Elevated factor VIII level was not assessed as a cause, at the moment. The rest of physical examination was normal. The diagnostic workup for secondary hypertension found a pathognomonic increase of renin activity with normal serum aldosterone level. The lower limb angiography showed complete occlusion of the left popliteal artery and partial obstruction of the right posterior tibial artery. A retroperitoneal CT angiography showed an atrophic left kidney and a narrowing of the left renal artery. The lower pole of the left kidney had normal transversal dimensions. This finding was attributed to the existence of a subsidiary artery supplying the renal parenchyma of the lower pole.The renogram showed a significant decrease in the left kidney perfusion by 70%. DSA angiography followed, revealing an atrophic left kidney with diffuse stenosis of the thin left renal artery, without the possibility of safe intervention. Results: Antihypertensive calcium channel blocker and beta-blocker were prescribed with a good outcome. The treatment of peripheral artery disease consisted of low molecular weight heparin and then oral anticoagulants with intravenous prostaglandins. After one year, the patient had a lower limb amputation, due to gangrene below the knee. Conclusions: The peculiarity of the case is that atherosclerosis manifested by peripheral artery disease was followed by renovascular hypertension. The assessment of secondary hypertension is, therefore, advisable even in patients presenting with limited peripheral occlusion of the arterial network, especially in young patients.
The Supreme Court under Marshall and Taney

Field: Arts and Humanities (Social Sciences)

The Supreme Court under Marshall and Taney Get access Newmyer R. Kent. The Supreme Court under Marshall and Taney. 2nd. ed. Wheeling, Ill.: Harlan Davidson, 2006. xii, 191 pp. $15.95. Timothy S. Huebner Timothy S. Huebner Rhodes College Search for other works by this author on: Oxford Academic Google Scholar American Journal of Legal History, Volume 47, Issue 3, July 2005, Pages 335–337, https://doi.org/10.2307/30039536 Published: 01 July 2005
Contact Metamorphic Effect on Basaltic Rocks by the Koyama Gabbro Complex, Susa Area, Southwest Japan

Field: Earth and Planetary Sciences (Physical Sciences)

Tertiary basaltic rocks around the Koyama gabbro complex mass, which occurs in the northeastern part of Yamaguchi Prefecture, have undergone intense contact metamorphism by the mass. Radiometric age determinations indicate that the metamorphism is of Miocene age. The contact aureole is rather narrow (a maximum of about 700 m), the metamorphic grade rapidly increasing toward the mass. In the comparatively lower temperature part of the contact aureole, the metamorphic paragenesis is actinolitic hornblende ± hornblende + epidote+ biotite+ oligoclase + quartz. Meanwhile, the highest-grade rocks are represented by the stable association of orthopyroxene+ clinopyroxene ± hornblende + biotite+ labradorite + quartz. The metamorphic temperature close to the contact with the mass is estimated to be 800 to 860°C. In the most-intensely metamorphosed basalts, most of such phenocrystic minerals as clinopyroxene and plagioclase can still preserve the essential chemical characteristics in the original rocks, whereas phenocrystic orthopyroxene appears to have been chemically changed its composition during the metamorphism.
Comparative analysis of primary versus relapse/refractory DLBCL identifies shifts in mutation spectrum

Field: Medicine (Health Sciences)

Current understanding of the mutation spectrum of relapsed/refractory (RR) tumors is limited. We performed whole exome sequencing (WES) on 47 diffuse large B cell lymphoma (DLBCL) tumors that persisted after R-CHOP treatment, 8 matched to primary biopsies. We compared genomic alterations from the RR cohort against two treatment-naïve DLBCL cohorts (n=112). While the overall number and types of mutations did not differ significantly, we identified frequency changes in DLBCL driver genes. The overall frequency of MYD88 mutant samples increased (12% to 19%), but we noted a decrease in p.L265P (8% to 4%) and increase in p.S219C mutations (2% to 6%). CARD11 p.D230N, PIM1 p.K115N and CD79B p.Y196C mutations were not observed in the RR cohort, although these mutations were prominent in the primary DLBCL samples. We observed an increase in BCL2 mutations (21% to 38% of samples), BCL2 amplifications (3% to 6% of samples) and CREBBP mutations (31% to 42% of samples) in the RR cohort, supported by acquisition of mutations in these genes in relapsed compared to diagnostic biopsies from the same patient. These increases may reflect the genetic characteristics of R-CHOP RR tumors expected to be enriched for during clinical trial enrollment. These findings hold significance for a number of emerging targeted therapies aligned to genetic targets and biomarkers in DLBCL, reinforcing the importance of time-of-treatment biomarker screening during DLBCL therapy selection.
Russia's New Drama From Togliatti to Moscow

Field: Arts and Humanities (Social Sciences)

Research Article| February 01 2006 Russia's New Drama From Togliatti to Moscow Yana Ross Yana Ross Search for other works by this author on: This Site Google Theater (2006) 36 (1): 27–43. https://doi.org/10.1215/01610775-36-1-27 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Yana Ross; Russia's New Drama From Togliatti to Moscow. Theater 1 February 2006; 36 (1): 27–43. doi: https://doi.org/10.1215/01610775-36-1-27 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsTheater Search Advanced Search The text of this article is only available as a PDF. © 2006 by Yale School of Drama/Yale Repertory Theatre2006 Article PDF first page preview Close Modal Issue Section: Articles You do not currently have access to this content.
California Soldiers in the Philippines: From the Correspondence of Howard Middleton, 1898-1899 (Continued)

Field: Arts and Humanities (Social Sciences)

Research Article| March 01 1952 California Soldiers in the Philippines: From the Correspondence of Howard Middleton, 1898-1899 (Continued) Harold F. Taggart, Harold F. Taggart Search for other works by this author on: This Site PubMed Google Scholar Howard Middleton Howard Middleton Search for other works by this author on: This Site PubMed Google Scholar California Historical Society Quarterly (1952) 31 (1): 49–67. https://doi.org/10.2307/25156338 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Harold F. Taggart, Howard Middleton; California Soldiers in the Philippines: From the Correspondence of Howard Middleton, 1898-1899 (Continued). California Historical Society Quarterly 1 March 1952; 31 (1): 49–67. doi: https://doi.org/10.2307/25156338 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCalifornia History Search This content is only available via PDF. Copyright 1952 The California Historical Society Article PDF first page preview Close Modal You do not currently have access to this content.
A fast and low power multiplier architecture

Field: Computer Science (Physical Sciences)

In this paper a new multiplier architecture is proposed for low power and high speed applications. It is based on generating all partial products in one step, then summing these partial products using binary tree network. This reveals a speedup of more than 50% than the array multiplier for (32/spl times/32) bit multiplication. Computer simulation with HSPICE shows that the new proposed architecture has better speed and power performance.
A novel synthesis of 2,4,6-trithiaheptane and its conversion into 2,6-bis(methylthio)thiane. Spectral properties of some thiaalkanes

Field: Chemistry (Physical Sciences)

2,4,6-Trithiaheptane (1a) has been prepared by lithium tetrahydridoaluminate reduction of the methiodide of 1,3,5-trithiane (2). Treatment of 1a with strong bases permitted formation of 3-alkylated derivatives (3) which could in turn be converted into diastereomeric mixtures of 3,5-dialkyl derivatives (4). A two-step alkylation of 1a with 1-bromo-3-chloropropane led to the formation of 2,6-bis(methylthio)thiane (5). Proton and 13 C nmr spectral studies on these compounds, including the measurement of long-range carbon–proton coupling constants, are described; their mass spectra showed elimination of methanethiol as a characteristic major fragmentation pathway.
Real‐world treatment patterns and clinical outcomes in patients with stage III NSCLC in Korea: The KINDLE study

Field: Medicine (Health Sciences)

Abstract Objective KINDLE‐Korea is part of a real‐world KINDLE study that aimed to characterize the treatment patterns and clinical outcomes of patients with stage III non‐small cell lung cancer (NSCLC). Materials and Methods The KINDLE was an international real‐world study that explores patient and disease characteristics, treatment patterns, and survival outcomes. The KINDLE‐Korea included stage III NSCLC patients diagnosed between January 2013 and December 2017. Results A total of 461 patients were enrolled. The median age was 66 years (range: 24–87). Most patients were men (75.7%) with a history of smoking (74.0%), stage IIIA NSCLC (69.2%), and unresectable disease (52.9%). A total of 24.3% had activating EGFR mutation and 62.2% were positive for PDL1 expression. Broadly categorized, 44.6% of the patients received chemoradiation (CRT)‐based therapy, 35.1% underwent surgery, and 20.3% received palliative therapies as initial treatment. The most commonly adopted approaches for patients with stage IIIA and IIIB disease were surgery and CRT, respectively. The median PFS was 15.2 months and OS was 66.7 months. Age >65 years, adenocarcinoma histology, and surgery as the initial treatment were significantly associated with longer OS. Conclusion This study revealed the heterogeneity of treatment patterns and survival outcomes in patients with stage III NSCLC before durvalumab consolidation came into clinical practice. There is an unmet need for patients who are not eligible for surgery as an initial therapy. Novel therapeutic approaches are highly warranted to improve clinical outcomes.
Diseases spectrum of metabolism disease of amino acid,organic acid and fatty acid oxidation in neonates

Field: Medicine (Health Sciences)

Objective To investigate the spectrum of neonatal-onset metabolic diseases such as amino acid diseases,organic acidemias and fatty acid oxidation disorders,so as to help pediatricians improve the awareness of these diseases.Methods From February 2003 to May 2012,2 547 neonates with suspected inherited metabolic disorders from all over China were tested by tandem mass spectrometry(MS/MS) and gas chromatography mass spectrometry(GC-MS).In the 127 confirmed cases,the analysis of disease spectrum and clinical manifestations was performed.Results In the 2 547 cases,a total of 127 cases(5%) were diagnosed with metabolic diseases.Thirty-seven cases(29.1%) were amino acid metabolic diseases in which ornithine transcarbamylase deficiency(16 cases) and maple syrup urine disease(14 cases) were common.Seventy-six cases(59.8%) were organic acid metabolic diseases in which methylmalonic acidemia(50 cases) was the most common,followed by propionic acidemia(13 cases) and isovaleric acidemia(10 cases).Another 14 cases(11%) were fatty acid oxidation disorders in which multiple CoA carboxylase deficiency(6 cases) was common.Conclusions In neonatal period,methylmalonic acidemia is the most common disease,followed by ornithine transcarbamylase deficiency,maple syrup urine disease,propionic acidemia and isovaleric academia.Pediatricians,especially neonatologists,should recognize the importance of the utilization of MS/MS and GC-MS in detection of inherited metabolic disorders and thus achive early diagnosis and early treatment.
Inverse Trans Influence in Low-Valence Actinide–Group 10 Metal Complexes of Phosphinoaryl Oxides: A Theoretical Study via Tuning Metals and Donor Ligands

Field: Chemistry (Physical Sciences)

The recognition and in-depth understanding of inverse trans influence (ITI) have successfully guided the synthesis of novel actinide complexes and enriched actinide chemistry. Those complexes, however, are mainly limited to the involvement of high-valence actinide and/or metal-ligand multiple bonds. Examples containing both low oxidation state actinide and metal-metal single bond remain rare. Herein, more than 20 actinide-transition metal (An-TM) complexes of phosphinoaryl oxide ligands have been designed in accordance with several experimentally known analogs, by changing the metal atoms (An = Th, Pa, U, Np, and Pu; and TM = Ni, Pd, and Pt), actinide oxidation states (IV and III) and metal-metal axial donor ligands (X = Me3SiO, F, Cl, Br, and I). The relativistic density functional theory study of structural (trans-An-X and cis-An-O toward An-TM), bonding (topological electron/energy density), and electronic properties reveals the order of the ITI stabilizing actinide-metal bond. Computed electron affinity (EA) values, related to the electrochemical reduction, linearly correlate with experimentally measured reduction potentials. Although the same ITI order for the ligand donors was shown as in a previous study, the correlation between electrochemical reduction and the ITI was found to be weak when the actinide atoms were changed. For most complexes, the reduction is primarily of an actinide-based mechanism with minor participation of transition metal and phosphinoaryl oxide, whereas that of thorium-nickel complexes is different.
File_SI. Observed densities of stink bugs at edges of field corn (Table 1) and soybean (Table 2), damages to corn kernels (Table 3) and, soybean yield, pod and seed damages (Table 4)

Field: Agricultural and Biological Sciences (Life Sciences)

This file contains the data used in the PLOS ONE article by Venugopal et al 2014. This paper describes patterns of stink bug density at edges of field crops (corn and soybean), in relation to adjacent habitat and distance from edge, and the associated damages to corn grain, soybean pod and seed, and yield.
Ovarian function after pelvic lymph node irradiation in patients with Hodgkin's disease submitted to oophoropexy during laparotomy.

Field: Medicine (Health Sciences)

Staging laparotomy for Hodgkin's disease was carried out on 110 women in fertile age at the General Surgery Department of Padua Medical School from 1972 to 1977. An oophoropexy was done during the operation. According to the stage the patients underwent radiation therapy that was associated in some cases to chemotherapy. Complete evaluation was possible only in 66 patients. Eighteen out of the 66 had mantle field and para-aortic lymph node chain radiotherapy. One case of amenorrhoea (5.5%) and five pregnancies (27.8%), were found among them. Nineteen had the same type of radiotherapy with MOPP. 3 cases of amenorrhoea (15.8%) and 3 pregnancies (15.8%) were found. Five had total nodal irradiation (TNI) according to Kaplan and all of them had amenorrhoea (100%). Twenty four had TNI associated to MOPP with 24 cases of amenorrhoea (100%). Our results slightly differ from those of other Authors. They showed: 1) that the oophoropexy is not effective using standard surgical technique (probably because of the size of the central shielding) as it causes amenorrhoea in 100% of the cases; 2) the incidence of permanent amenorrhoea from chemotherapy with MOPP is the same as reported by other Authors; 3) the absence of teratogenic effects by chemotherapy in newborns of these patients.
Yeast probiotic Saccharomycopsis fibuligera alleviates the colorectal cancer by inhibiting the choline metabolism

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract

The role of the microbiome in disease pathogenesis and anti-inflammatory effects of certain commensal microorganisms support the probiotic-based therapies for tumor treating. Saccharomycopsis fibuligera (S.fibuligera) is the major amylolytic yeast used in food fermentation. As a natural medicine, S.fibuligera has been found to protect the intestinal mucosa, while its role and related mechanisms in colorectal cancer (CRC) remain unexplored. In this study, we found that S.fibuligera could alleviate the development of CRC in mice, inhibit the proliferation of tumor cells and induce their apoptosis in vitro. Mechanistically, several metabolic pathways of tumor cells changed after S.fibuligera treatment, among which choline metabolism changed significantly. S.fibuligera inhibited choline metabolism of CRC cells by targeting and inhibiting the Ras/PI3K/AKT pathway, thereby reducing the expression of related metabolites, activating the AMPK pathway and inhibiting the mTOR pathway, which in turn induced apoptosis of CRC cells, ultimately alleviating CRC. Above all, our study has clarified anti-tumor effect of S.fibuligera and demonstrated that S.fibuligera alleviates CRC by inhibiting the choline metabolism, providing a promising new strategy for CRC treatment with high clinical translational value.
European Union and Post-Soviet Countries: New Trends in Development Assistance

Field: Social Sciences (Social Sciences)

The article analyzes the policy in the field of international development assistance implemented by the EU in the post-Soviet space. It is shown that in the second half of the 2010s – early 2020s the largest European donor countries perceived this region as peripheral. The main part of the funds was allocated by the supranational authorities of the EU. Geographically, most official development assistance (ODA) was provided to Eastern European countries and the South Caucasus, while development assistance to Central Asia was financed on a residual basis. After the crisis in Ukraine escalated in 2022, the EU’s collective ODA increased sharply, and the country itself became the main recipient of European assistance. However, the bulk of aid is expenditure on refugees in donor countries, which is statistically recorded as ODA. Financing of projects on the territory of Ukraine itself is not so significant. In the context of the degradation of relations between Russia and the West, the EU countries are interested not so much in the reconstruction of the Ukrainian economy, but in using the anti-Russian potential of Ukraine. In this regard, not economic, but military assistance is of paramount importance.
Information-Theoretic Scales for Measuring Cultural Rule Systems

Field: Social Sciences (Social Sciences)

This research was supported by the Russell Sage Foundation. Thanks are expressed to H. Levene and B. H. Singer, who offered numerous useful suggestions about the manuscript, and to the following participants in the 19781979 culture program at the Russell Sage Foundation, whose comments helped the author to formulate the experimental design: Karen Curtis, Judith Goode, Judit Katona-Apte, Marla Powers, Bill Powers, Janet Theophano, and Tony Whitehead. Thanks are also due to Bruce Styne, who wrote and ran the computer programs that analyzed the data, as well as to Aaron Gross and Joel Stein, who assisted him.
Nutrient Use Efficiencies and Correlation Studies on Rice Fallow Irrigated Maize

Field: Agricultural and Biological Sciences (Life Sciences)

A field experiment was conducted at Agricultural College and Research Institute, TNAU, Madurai during January to April 2017 to investigate the influence of nitrogen fertilization on roots, nutrient uptake and productivity of rice fallow hybrid maize. The experiment was laid out in a randomized block design with three replications. Seven treatments under rice fallow condition with graded levels of N viz., 100(T1 ), 125 (T2 ), 150 (T3 ), 175 (T4 ), 200 (T5 ), 225 (T6 ) and 250 kg ha-1 (T7 ) were evaluated. Maize hybrid CoMH 6 was used with a recommended spacing of 60 × 25 cm. The grain yield was found to be significantly higher with the application of 250 kg of N ha-1; however, it was found to be comparable with 225 and 200 kg of N ha-1. The fertilizer use efficiencies increased with decreasing levels of N. Positive and significant correlation was observed between different doses of N and LAI, no. of grains cob-1, grain yield and net income. LAI and no. of grains cob-1 were also found to have significant positive correlation with yield.
Application of Genetic Polymorphisms in DNA Repair in the Prediction of Cancer Susceptibility and Clinical Outcome

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The capacity to repair damaged DNA is a basic tool by which the mammalian cell maintains its genetic integrity and prevents neoplasm; however, DNA repair function could be modified by genetic polymorphisms. Recent molecular epidemiological studies have indicated that these genetic variants occur in the normal population and can be used to predict individual cancer risk. Since variation in the function of these genes might impact a cancer cell ’ s viability or resistance to treatment, genetic variants in DNA repair might act as a valuable marker in forecasting the results of cancer treatment. This possibility has been outlined by some clinical pilot studies of genetic polymorphisms in the DNA repair genes. With the biological importance of the DNA repair genes, studies of these genetic variants occurring in the general population will further our understanding of cancer etiology and behavior. Keywords: DNA repair, polymorphisms, cancer risk, treatment