jimnoneill/paper-to-field-training huggingface dataset:
The potential effect of the COVID-19 pandemic on women’s reproductive health

Field: Medicine (Health Sciences)

Annotation. A review of the scientific literature related to the problem of the potential effect of the covid-19 pandemic on women's reproductive health is presented. To date, there are various hypotheses of pathogenesis and ways of detecting changes in a woman's reproductive health, which we will consider. In the context of the COVID-19 pandemic, it is likely that menstrual disturbances are a possible consequence of changes in mental health or a direct effect of the virus on the cells of the reproductive system. For example, research findings suggest that women who have experienced COVID-19 have experienced menstrual changes, including changes in the duration, frequency, regularity, and volume of menstruation (increased bleeding and blood clotting), increased dysmenorrhea, and worsening of premenstrual syndrome (PMS). However, the data available today are not reliable enough to draw firm conclusions on this topic. The purpose of our work is to study the potential impact of the COVID-19 pandemic on women's reproductive health. We conducted a systematic literature review and analysis based on PubMed, ScienceDirect, UpToDate, Web of science, and Scopus databases. When searching for information on the prevalence and prevention of reproductive dysfunction in women who have contracted a coronavirus infection, various combinations of the following keywords were used: “Reproductive health”, “COVID-19”, “pandemic”, “menstrual cycle”, “hormones”. When processing the search results, the most recent publications (for the last 5 years) or the latest publications on this issue (regardless of the age) were chosen. The problem of the potential negative impact of the COVID-19 pandemic on women's reproductive health in the practice of gynecologists around the world is becoming more relevant every year, because the study of the consequences of administrative restrictions in the public health system, violations from the mental system, direct and secondary effects is becoming more relevant virus on the reproductive system. Various menstrual changes (duration, frequency, regularity and volume of menstruation), which can cause a negative socio-psychological impact on women. High-quality work of gynecologists, starting with early detection of disorders, diagnostic and treatment tactics can improve a woman’s condition or reveal secondary causes of such changes.
Gender Detection on Social Networks using Ensemble Deep Learning

Field: Computer Science (Physical Sciences)

Analyzing the ever-increasing volume of posts on social media sites such as Facebook and Twitter requires improved information processing methods for profiling authorship. Document classification is central to this task, but the performance of traditional supervised classifiers has degraded as the volume of social media has increased. This paper addresses this problem in the context of gender detection through ensemble classification that employs multi-model deep learning architectures to generate specialized understanding from different feature spaces.
Investigation of the possibility of biological modification and regeneration of plant-based sorption materials

Field: Environmental Science (Physical Sciences)

The paper considers the possibility of using biomass of hogweed Sosnowski as a sorbent of petroleum products in aqueous medium. The expediency of using plant sorbent in complex with cyanobacteria to increase sorption activity towards petroleum products is proved. The prospectivity of the use of cyanobacteria as a biological regenerator of the used plant sorbent is shown.
Infectious problems after elective surgery of the alimentary tract: the influence of peri-operative factors

Field: Medicine (Health Sciences)

A prospective multi-centre study was carried out on 1537 patients to investigate the influence of some peri-operative factors on the infectious complications after elective abdominal surgery in surgical departments where a standardized prophylactic antibiotic regimen is used regularly. The antibiotic regimen consisted of 1600 mg tinidazole and 400 mg doxycycline given intravenously 1-hour preoperatively. The results showed that total gastrectomy seemed to give higher infection rates than other gastroduodenal procedures. Low anterior and abdomino-perineal rectal resections were followed by more infectious complications than colonic resections, but this difference was significant only due to the perineal wound infections and failures of the low anterior anastomosis. Prolonged operation time was followed by increased number of infectious complications only when prophylaxis was not given. Blood transfusions led to a highly significant increase in infectious complications. Peri-operative surgical complications, splenectomy and stoma formation did not influence post-operative infectious complications.
Differences in health status between long-term and short-term benzodiazepine users.

Field: Medicine (Health Sciences)

Specific risk characteristics of long-term benzodiazepine users can be used to develop a risk profile for the management of benzodiazepines in general practice. We believe that (somatic) secondary care also contributes to benzodiazepine use. It may be worthwhile to coordinate care for benzodiazepine users between GPs and hospital specialists.
Agomelatine’s effect on human genetic material: in vitro study

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Eισαγωγή: Η αγομeλατίνη αποτeλeί ένα eγκeκριμένο φάρμακο για τη θeραπeία της μeίζονος καταθλιπτικής διαταραχής. Παρουσιάζeι δράση μeλατονινeργικού αγωνιστή και ανταγωνιστή των 5-HT2C υποδοχέων της σeροτονίνης. Σκοπός της παρούσας έρeυνας eίναι η μeλέτη της eπίδρασης της αγομeλατίνης στο ανθρώπινο DNA in vitro μe τον υπολογισμό eυαίσθητων κυτταρογeνeτικών δeικτών. Υλικό και Μέθοδος: Oι χρωματιδιακές ανταλλαγές (Sister Chromatid Exchanges, SCEs) θeωρούνται ένας από τους πιο eυαίσθητους δeίκτeς γονοτοξικότητας. O δeίκτης ρυθμού πολλαπλασιασμού (Proliferation Rate Index, PRI) eίναι ένας από τους πιο αξιόπιστους δeίκτeς κυτταροστατικότητας, eνώ ο μιτωτικός δeίκτης (Mitotic Index, MI) δeίχνeι μe ακρίβeια την ικανότητα του κυττάρου για πολλαπλασιασμό. Αρχικά παρασκeυάστηκαν διαλύματα αγομeλατίνης πέντe διαφορeτικών συγκeντρώσeων (A=2.5μg/ml, B=5μg/ml, C=10μg/ml, D=15μg/ml και E=20μg/ml). Oι συγκeντρώσeις B και C eίναι οι πιο συχνά χρησιμοποιούμeνeς στην κλινική πράξη. Τα διαλύματα προστέθηκαν σe καλλιέργeιeς λeμφοκυττάρων από πeριφeρικό αίμα τeσσάρων νeαρών υγeιών αιμοδοτών. Μeτά από 72 ώρeς eπώασης, μe την κατάλληλη τeχνική τα καλλιeργημένα λeμφοκύτταρα eπιστρώθηκαν σe αντικeιμeνοφόρους πλάκeς, χρωματίστηκαν μe την μέθοδο Fluorescence plus Giemsa και οι προαναφeρθέντeς δeίκτeς υπολογίστηκαν μe οπτικό μικροσκόπιο. Αποτeλέσματα: Η ανάλυση των αποτeλeσμάτων αποκάλυψe στατιστικά σημαντική αύξηση των χρωματιδιακών ανταλλαγών και μeίωση τόσο του δeίκτη ρυθμού πολλαπλασιασμού όσο και του μιτωτικού δeίκτη . Eπιπρόσθeτα, προέκυψe συσχέτιση μeταξύ α) της αύξησης των SCEs και των μeταβολών του ΜΙ και του PRI και β) των μeταβολών ΜΙ-PRI. Συμπeράσματα: Η αγομeλατίνη σe θeραπeυτικές δόσeις προκάλeσe δοσοeξαρτώμeνeς μeταβολές στους υπό μeλέτη κυτταρογeνeτικούς δeίκτeς. Το παραπάνω eνδέχeται να καταδeικνύeι στοιχeία για το μηχανισμό δράσης του φαρμάκου. Λαμβάνοντας υπόψη την αυξανόμeνη χρήση της αγομeλατίνης eπιβάλλeται πeρeταίρω μeλέτη της κυτταρογeνeτικής της δράσης σe πeρισσότeρους αιμοδότeς καθώς και σe άλλeς κυτταρικές σeιρές.
Geonatural Resources Planning

Field: Earth and Planetary Sciences (Physical Sciences)

The rapid increase in the development of land, the exploitation of minerals, and the related accelerated environmental impacts have caused an explosion of demand for information that can be used as a guide to land use decision-making. "Environmental Geology Mapping" was the topic of an engineering geology symposium at the 1972 annual meeting of The Geological Society of America; natural resources planning and the roles and interrelations of geology and geologists, planning and planners were discussed. This book presents the coverage of those subjects because of their continuing timeliness and the need for a reminder that we must provide data that are relevant and usable for interdisciplinary considerations in natural resources planning. The authors express their ideas on how to translate professionally the traditional, basic earth-science data into forms that are adaptable to interdisciplinary solutions of environmental problems. They unanimously state that this conversion of data has to result in a viable input for decision-making, and it must also stand the scrutiny of the real world; that is, it must receive public endorsement and support.
Non-Stationary Estimation in Gravity Prediction Problems.

Field: Earth and Planetary Sciences (Physical Sciences)

This report investigates the impact that the assumptions of homogeneity and isotropy, when applied to potential related fields, have upon the stochastic processes which are applied to these fields. After seeing how these assumptions are incorporated into the statistical model to produce the familiar covariance function, the investigation centers on techniques which can be used to detect the presence of anisotropy in the field. The method found most useful in the two-dimensional covariance function, and some methods of representing this function are also investigated. Numerical studies are then carried out to see the effect the use of the 2-D covariance function has upon the results of prediction and collocation computations. It is found that, under certain circumstances, the 2-D function produces a result superior to that given by the general function. Recommendations are then given as to when the 2-D covariance function should be used in practical solutions, and suggestions made as to the possible areas of futher research. (Author)
Identification of four novel cytochrome P4501B1 mutations (p.I94X, p.H279D, p.Q340H, and p.K433K) in primary congenital glaucoma patients.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Mutations in CYP1B1 are a major cause for PCG in our patients. Identifying mutations in subjects at risk of developing glaucoma, particularly among relatives of PCG patients, is of clinical significance. These developments may help in reducing the disease frequency in familial cases. Such studies will be of benefit in the identification of pathogenic mutations in different populations and will enable us to develop simple and rapid diagnostic tests for analyzing such cases.
Informational Regulation of Industrial Safety - An Examination of the U.S. "Local Emergency Planning Committees"""

Field: Social Sciences (Social Sciences)

A major trend in the regulation of industrial risks to human health and the environment is the provision of relevant information to (and the empowerment of) all stakeholders and risk bearers. This paper provides a concrete look at one of the key items in implementing this "regulation by information"" in the United States: the so-called LEPCs or Local Emergency Planning Committees. We summarize the literature on the subject, report on some interviews we made at selected LEPCs in the states of Vermont and Maryland, and present preliminary figures from a recent survey we just completed of more than 200 LEPCs. The ending sections also contain some international comparisons and an appraisal of the actual LEPCs." La nouvelle tendance dans les réglementations concernant les risques industriels à la santé humaine et à l'environnement est de diffuser l'information pertinente à toutes les parties prenantes. Cet article considère l'un des outils clés de cette « régulation des risques par l'information » : les comités locaux de planification d'urgence, aux Etats-Unis (désignés en anglais par le sigle LEPC). Nous dressons un bilan de la littérature sur le sujet. Nous intégrons des éléments importants résultant d'entrevues faites auprès de LEPCs sélectionnés dans les États du Vermont et du Maryland. Et nous présentons certains résultats préliminaires d'une enquête récente que nous venons de réaliser auprès de plus de 200 LEPCs. Les sections finales contiennent également plusieurs comparaisons internationales et une appréciation du fonctionnement actuel des LEPCs.
Drought in the forest breaks plant–fungi interactions

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Drought in the forest is not only a prolonged state of water shortage, but also an occasion where interactions between plants and fungi are affected. Water efficiency accelerates a range of pathologies in interactions between organisms, influencing the ecosystems and their interacting biological components. This study focuses on the role of mycorrhizal and endophyte fungi in alleviating the effects of soil water shortage, and on the impact of their altered activity during drought on the health of trees. The issues presented here show the fundamental role of the mycorrhizal mycelium and the mechanism of water transport to the plant in the course of other phenomena (withering, pathogenesis, endophytes biology) that occur in trees under influence of drought, with particular attention on managed coniferous stands. Conclusions resulting from published information on this topic emphasize the negative impact of soil moisture deficiency on the ectomycorrhizal fungi functioning and, in contrast, on the promotion of the growth of some endophytes, pathogens and hemi-parasitic mistletoes ( Viscum spp.).
Addressing Obesity in the Oceanic Population: Challenges, Solutions, and Pathways to Health

Field: Medicine (Health Sciences)

This study is a triphasic exploration of the Oceania region’s disproportionate obesity rates and access to obesity related clinical trials. To accomplish this, this study investigated the prevalence of obesity clinical trials compared to the worldwide population proportion, the validation of existing obesity data for this population, and the application of exercise and non-exercise-based clinical trials. No statistically significant relationship was noted between the regional population and obesity clinical trial proportions. Simply, the size of a regional population did not directly influence the number of clinical trials. However, findings did validate that Oceanic populations exhibit higher Body Mass Index (BMI) values compared to the global population, in alignment with previous literature. One sample t-tests revealed a statistically significant difference (p <.001) difference between mean BMI, obesity rate (BMI >30), and morbid obesity rate (BMI >40) in Oceanic populations compared to worldwide rates. Despite the disproportionate obesity rates in this demographic, a negligible number of clinical trials, especially those including exercise interventions, have been made available to this population. Finally, exercise-based clinical trials were used infrequently worldwide, a rate that was exceptionally low amongst studies conducted in the Oceania region. Of note, emerging literature suggests that Oceanic populations, specifically Polynesians, exhibit a genetic anomaly that increases body mass without necessarily increasing fat mass via allele rs373863828. Thus, while the existing BMI data expresses significantly higher obesity rates, more comprehensive research is needed on this population to understand this demographic’s typical body composition. Otherwise, some areas within the Oceania region continue to exhibit obesity rates exceeding five times that of the world average, yet are rarely provided with obesity clinical trials to mitigate obesity-related disease and comorbidities. These findings suggest a need for more equitable allocation of research resources to address the unique challenges posed by obesity in the Oceanic population.
FAIRsharing record for: International Ocean Discovery Program Laboratory Information Management System

Field: Earth and Planetary Sciences (Physical Sciences)

This FAIRsharing record describes: The International Ocean Discovery Program (IODP) is an international research collaboration that coordinates seagoing expeditions to study the history of the Earth recorded in sediments and rocks beneath the ocean floor. This resource contains Phase II of the Integrated Ocean Drilling Program and all of the International Ocean Discovery Program data in the new system.
A pilot study of the bioavailability and pharmacokinetics of 2',3'-dideoxycytidine in patients with AIDS or AIDS-related complex.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Eight patients with AIDS or ARC received four single doses of 2',3'-dideoxycytidine (ddC). The treatments included 0.5 and 5 mg oral tablets, a 0.5 mg oral solution, and a 0.5 mg intravenous infusion. Blood samples were collected for 4 to 6 h after each dose. Plasma concentrations of ddC were determined by a specific gas chromatographic-mass spectrometric (GC-MS) assay. A combination of the low dose and the assay sensitivity of 2 ng/ml limited data treatment and comparison. Mean Cmax of 8.5, 7.6, and 79.0 ng/ml occurred at mean tmax of 1.1, 1.3, and 0.9 h for the 0.5 mg oral solution, the 0.5 mg tablet, and the 5 mg tablet, respectively. A mean clearance of 5.57 ml/min/kg and volume of distribution of 0.64 L/kg were determined from the 0.5 mg intravenous infusion. Half-life values ranged between 0.95 and 2.0 h and appeared to be independent of the dose and route of administration. The bioavailability values calculated for the oral tablets were variable, ranging from 54 to 127%. Single doses of ddC were well tolerated in this population. The results of this pilot study indicate that ddC is rapidly and extensively absorbed when administered as an oral tablet or solution to fasting AIDS or ARC patients. It is also rapidly eliminated with a half-life of 1-2 h. There are no apparent differences in the absorption or elimination of ddC between 0.5 and 5 mg oral doses.
Acute disseminated encephalomyelitis following infectious mononucleosis in a toddler

Field: Medicine (Health Sciences)

Symptomatic Epstein-Barr virus (EBV) infection complicated by acute disseminated encephalomyelitis (ADEM) in a toddler is rare. Our patient is a 14 month-old boy who presented with listlessness and reduced eye movements nearly 10 days after a prodromal upper respiratory illness that was accompanied by an amoxicillin rash. On examination, the boy appeared drowsy, had a congested throat and a resolving lower extremity rash, but otherwise had a normal neurological examination. Investigation revealed lymphocytosis, mildly elevated liver enzyme and a positive EBV IgM serology. Cerebrospinal fluid analysis showed pleocytosis. Subsequent brain and spine MRI showed demyelinating disease extending from the cerebral peduncles, across the brain stem and down to the mid-thoracic spinal cord. The patient was treated as a case of ADEM and given intravenous methylprednisolone. On outpatient follow-up his symptoms resolved completely in 6 weeks.
Patch testing in drug cutaneous adverse reactions: value of the extemporaneous preparations

Field: Medicine (Health Sciences)

Patch testing (PT) is a part of tools used for the etiological diagnosis of a cutaneous adverse reaction (CADR). Positivity of PT is observed in above 30 to 50 % of explored cases. Recommended procedure is based on dilution in petroleum or in water at 30 % for the finished product or at 10 % for the active ingredient. Chemotechnique laboratory supplies, in the form of ready for use syringes, around 30 active ingredients. Other medicines must be thus prepared by a hospital pharmacy, according to the strict protocol. Thus, preparations are not available in all the test centers and some patients can not be explored. We led a forward-looking study comparing the extemporaneous tests, easily practicable, compared with the recommended procedures. Patients and methods The programmed tests were performed at the same time with Chemotechnique products or pharmaceutical preparations and with tablets brought by the patients, crushed manually with a pestle in order to transform in powder and then mixed in petroleum. The used chambers were Q or IQ chambers (Chemotechnique) and the readings realized at 48 and 96 hours. 70 patients (25 men/ 45 women) were included. Seven were tested with 2 different molecules, thus 77 double tests were performed. Tested substances included usual CADR inducers such as allopurinol (n=9), amoxicillin (n=25), tetrazepam (n=7), pristinamycin (n=10) and 16 others molecules. CADR tested included maculopapular rash (MPR; n=27), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS; n=9), Acute Generalized Exanthematous Pustulosis (AGEP; n=12), Fixed Drug Reaction (FDE; n=5), Linear IgA Dermatosis (n=2), Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (n=15), erytroderma (n=3) and eczematous rash (n=2). All the tests were coherent: 20 positive tests and 57 negative with the 2 techniques. As usually observed in literature with recommended patch testing, the positive tests were observed preferentially with some ingredients (amoxicillin, tetrazepam, pristinamycin) and conversely there was no positive tests with allopurinol, ibuprofen and piroxicam. As well, patch testing was more frequently positive with some kinds of CADR (AGEP and MPR), confirming reliability of the tests. For the patients that could not consult easily in centers having access to the pharmaceutical preparations but nevertheless expert in CADR, the extemporaneous preparations constitute a possible alternative.
The protective effect of Gabexate mesilate on D-galactosamine-lipopolysaccharide-induced acute liver failure in rats

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Objective To investigate the protective effect of Gabexate mesilate(GM)on D-galactosamine- lipopolysaccharide-indneed acute liver failure in rats.Methods The model of acute liver failure in rats was produced by injection of D-galactosamine(D-GalN)and lipopolysaccharide(LPS).The alanine aminotransferase(ALT),aspartate aminotransferase(AST)in serum and malondiadehyde(MDA)content,superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX)activities in liver homogenate were assayed by spectrophotometry.The levels of turnout necrosis factor-α(TNF-α),interleukin-β(IL-β)and interleukin-6(IL-6)were determined by ELISA method.Hepatic pathological examination was observed.Results 25 mg·kg~(-1),50mg·kg~(1),100 mg·kg~(-1) of GM significantly decreased the serum transaminase activities,the infiltration of inflammatory cells,and MDA content,hut didn't reduce SOD and GSH- PX activities in liver homogenate.GM significantly reduced TNF-α,IL-1βand IL-6 levels in serum.Conclusions GM showed significant protective effects on acute liver failure in rats.