jimnoneill/paper-to-field-training huggingface dataset:
In vivo correction of anaemia in beta-thalassemic mice by gammaPNA-mediated gene editing with nanoparticle delivery

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The blood disorder, beta-thalassaemia, is considered an attractive target for gene correction. Site-specific triplex formation has been shown to induce DNA repair and thereby catalyse genome editing. Here we report that triplex-forming peptide nucleic acids (PNAs) substituted at the gamma position plus stimulation of the stem cell factor (SCF)/c-Kit pathway yielded high levels of gene editing in haematopoietic stem cells (HSCs) in a mouse model of human beta-thalassaemia. Injection of thalassemic mice with SCF plus nanoparticles containing gammaPNAs and donor DNAs ameliorated the disease phenotype, with sustained elevation of blood haemoglobin levels into the normal range, reduced reticulocytosis, reversal of splenomegaly and up to 7% beta-globin gene correction in HSCs, with extremely low off-target effects. The combination of nanoparticle delivery, next generation gammaPNAs and SCF treatment may offer a minimally invasive treatment for genetic disorders of the blood that can be achieved safely and simply by intravenous administration.
From Panarchy to Anarchy: The Relational Resilience of (More-Than-Human) Subjects in Processes of Subjectivation

Field: Social Sciences (Social Sciences)

In this conceptual text, I would like to outline a few thoughts that do not yet represent a completed concept or a finished research approach. They are fragments of an approach towards an understanding of relational resilience. This will serve to explore questions of psycho-social resilience and resilience factors archaeologically, without falling back into essentialist notions of the human psyche, physis or social context. The understanding of relational resilience is embedded in reflections on practices of subjectivation. They are intended to help me, and of course others, to understand how we can grasp the resilience of subjects without reducing it to the mind or the individual, as a member of society or as a human being. So, I am interested in the resilience of (more-than-human) subjects without presupposing reductionisms, such as methodological individualism or humanism, from the outset.
Mobile home weatherization measures: A study of their effectiveness

Field: Energy (Physical Sciences)

The Solar Energy Research Institute (SERI) was funded by the Department of Energy's Office of Buildings and Community Systems (DOE OBCS) in FY 1987 and 1988 to investigate cost effective ways to weatherize mobile homes constructed prior to the enactment of HUD Thermal Standards in 1976. In FY 1987 SERI studied the effectiveness of a variety of infiltration-reducing retrofits by monitoring 20 units in the field before, during, and after applications of air tightening measures. In FY 1988 we began studying measures intended to reduce envelope conduction losses. These measures included storm windows, insulated skirting, and wall, roof, and floor insulation. This part of the project resulted in the development of a short-term testing method for measuring the thermal impact of individual conduction-reducing retrofits.
EEG Emotion Recognition Method Based on 3D Feature Map and Improved DenseNet

Field: Computer Science (Physical Sciences)

<p>Emotion, as a high-level function of the human brain, has a great impact on people’s mental health. To fully con-sider EEG signals’ spatial information and time-frequency information, and realize human-computer interaction better. This paper proposes an improved DenseNet emotion recognition model based on 3D feature map. By extracting the differential entropy features of the &theta;, &alpha;, &beta; and &gamma; frequency bands of the EEG signals, and combining the position mapping relationship of the EEG channel electrodes, a three-dimensional feature map is constructed, and then the improved densely connected convolutional network (DenseNet) is used for secondary feature extraction and classification. To verify the effectiveness of this method, a classification experiment including positive, neutral and negative emotions is carried out on the SEED data set. The classification accuracy rates obtained in the single-subject experiment and the all-subject experiment are 98.51% and 98.68%, respectively. The experimental results show that the method of 3D feature map combined with feature reuse can get high-precision classification results, which provides a new direction for emotion recognition.</p> <p>&nbsp;</p>
Initial Experimental Characterization of a New Ultra-High Resolution FTICR Cell with Dynamic Harmonization

Field: Chemistry (Physical Sciences)

A new Fourier transform ion cyclotron resonance (FTICR) cell based on completely new principles of formation of the effective electric potential distribution in Penning type traps, Boldin and Nikolaev (Proceedings of the 58th ASMS Conference, 2010), Boldin and Nikolaev (Rapid Commun Mass Spectrom 25:122-126, 2011) is constructed and tested experimentally. Its operation is based on the concept of electric potential space-averaging via charged particle cyclotron motion. Such an averaging process permits an effective electric force distribution in the entire volume of a cylindrical Penning trap to be equal to its distribution in the field created by hyperbolic electrodes in an ideal Penning trap. The excitation and detection electrodes of this new cell are shaped for generating a quadratic dependence on axial coordinates of an averaged (along cyclotron motion orbit) electric potential at any radius of the cyclotron motion. These electrodes together with the trapping segments form a cylindrical surface like in a conventional cylindrical cell. In excitation mode this cell being elongated behaves almost like an open cylindrical cell of the same length. It is more effective in ion motion harmonization at larger cyclotron radii than a Gabrielse et al.-type (Int J Mass Spectrom Ion Processes 88:319-332, 1989) cylindrical cell with four compensation sections. A mass resolving power of more than twenty millions of reserpine (m/z 609) and more than one million of highly charged BSA molecular ions (m/z 1357) has been obtained in a 7T magnetic field.
Unstructured overset incompressible computational fluid dynamics for unsteady wind turbine simulations

Field: Engineering (Physical Sciences)

ABSTRACT Overset computational fluid dynamics (CFD) methods are the most sophisticated methods currently available to predict the unsteady motion of wind turbine blades without the need for additional simplifications or restrictions on the turbine operational conditions. An unstructured implementation of the governing equations of motion permits rapid modeling of the salient components, such as nacelles, towers and other localized obstructions of interest. A time‐accurate incompressible formulation accelerates the convergence of the solution, in addition to eliminating the need for low‐Mach number preconditioning, which can be problematic and computationally expensive for time‐accurate simulations. The use of a hybrid Reynolds‐averaged Navier–Stokes/large eddy simulation (RANS/LES) turbulence method is observed to improve the prediction and extent of separation, as well as integrated performance variables for stalled rotors under fully turbulent conditions. Copyright © 2012 John Wiley & Sons, Ltd.
Experience with Norcuron, a muscle relaxant of average duration of neuro-muscular effect.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

In course of the anaesthesia of orthopaedic and general surgery operations, the author administered Norcuron injection in 80 cases for the purpose of intubation and/or surgical myorelaxation. On account of the observation of the usual parameters, he found Norcuron to be a product meeting the expectations, furnishing myorelaxation of medium length that did not cause adverse alterations, in circulation neither did it have other unpleasant side- or after-effect. The author applied a so-called priming dose system by which the time required for intubation could be appreciably shortened. He recommends this procedure to others, too.
The Influence Of Work Environment, Work Discipline And Motivation on The Performance of Civil Servants at The Inspectorate of East Java Province

Field: Business, Management and Accounting (Social Sciences)

Institutions and organizational development depend on human resources. Humans always play an active role in every organizational activity because humans are planners, actors and determinants of the realization of organizational goals. The aim of this research is to test, prove and analyze the influence of the work environment, work discipline and motivation on employee performance. This research uses primary data in the form of distributed questionnaire data. The sample used was 45 respondents, sampling criteria were used. The analysis used in this research is SEM analysis. Based on the research results, it can be concluded that work discipline and motivation variables influence employee performance, while environmental variables influence employee performance. Thus, the delivery and suggestions, namely the implementation of an online attendance system, can potentially increase the level of employee discipline, due to more effective monitoring of attendance and absence. This system can make a positive contribution to employee performance by providing accurate data on whereabouts, enabling management to plan and optimize task assignments. Involve employees in system development and implementation to ensure that the system meets their needs and adds value to daily tasks. Keywords: Work Environment, Work Discipline, Motivation And Performance, Employee Performance.
Partners in Profession: Inwardness, Experience, and Understanding in Heloise and Abelard

Field: Arts and Humanities (Social Sciences)

Heloise and Abelard demonstrate how the experiential quality of thinking itself and the reciprocal influence of thought and feeling can function within Latin learning.KeywordsTwelfth CenturyReciprocal InfluenceIntroductory LetterBiblical StoryHide MeaningThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Activities-Specific Balance Confidence in People with Multiple Sclerosis

Field: Health Professions (Health Sciences)

Objective . To evaluate the validity of the Activities-specific Balance Confidence scale (ABC) in people with multiple sclerosis (PwMS). Design . A multicentre, cross-sectional study. Setting . Six rural and urban Swedish sites, including specialized units at hospitals and primary care centers. Participants . A sample of 84 PwMS with subjective gait and balance impairment but still able to walk 100 m (comparable with EDSS 1–6). Outcome Measures . Timed Up and Go, Timed Up and Go cog , 25-foot Timed Walk Test, Four Square Step Test, Dynamic Gait Index, Chair Stand Test, 12-item MS Walking Scale, self-reported falls, and use of assistive walking device were used for validation. Results . The concurrent convergent validity was moderate to good (0.50 to −0.75) with the highest correlation found for the 12-item MS Walking Scale. The ABC discriminated between multiple fallers and nonfallers but not between men and women. Ecological validity is suggested since ABC discriminated between users of assistive walking device and nonusers. The internal consistency was high atα=0.95,and interitem correlations were between 0.30 and 0.83. Conclusion . This study supports the validity of the ABC for persons with mild-to-moderate MS. The participants lacked balance confidence in many everyday activities, likely restricting their participation in society.
Additional file 2 of Genome-wide association study uncovers major genetic loci associated with flowering time in response to active accumulated temperature in wild soybean population

Field: Agricultural and Biological Sciences (Life Sciences)

Additional file 2: Fig. S1. Distribution of SNP number in different chromosomes and count of MAF. A, SNP numbers. B, SNP frequency in different minor allele frequency. Fig. S2. Distributions of SNP linkage disequilibrium decay and heterozygosity. A, Linkage disequilibrium decay (r2) across different linkage disequilibrium windows in 294 wild soybean accessions. B, Histogram of heterozygosity for SNPs. Fig. S3. Boxplot representing the distribution of flowering time in five active accumulated temperature zones in Heilongjiang province, China. A, flowering time data recorded in 2020; B, flowering time data recorded in 2021. Active accumulated temperature zones have five types (I, II, III, IV, and V). Fig. S4. Histogram of flowering time recorded from two consequent years. A, 2020 phenotyping of flowering days. B, 2021 phenotyping of flowering days. Fig. S5. Correlation of flowering time between two-year experiments in 2020-2021. Pearson correlation coefficient (r) was used. Fig. S6. Haplotype distribution of candidate genes against active accumulated temperature (AAT) zones. A, Glyma.02g100800. B, Glyma.04g096000. C, Glyma.09g279900. Fig. S7. Haplotypic distribution of flowering time in 2020-2021 for three candidate genes. A-B, TAXi_N haplotypes analysis in 2020 and 2021. C-D, EDR1 haplotypes analysis in 2020 and 2021. E-F, SCAR2 haplotypes analysis in 2020 and 2021. Different letters represent the significant levels at P <0.05 based on one-way ANOVA.
Possible Role of Vasopressin in the Thermoregulatory Response to Chlorpyrifos in the Rat

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract: Arginine vasopressin is a naturally occurring antipyretic which is released into the CNS to prevent excessive elevations in body temperature during fever. Circulating levels of arginine vasopressin may also have a role in the tonic control of body temperature. We have found that the organophosphate insecticide chlorpyrifos will raise blood pressure and lower body temperature in the rat. Because arginine vasopressin is a potent hypertensive agent and is capable of lowering core temperature, we suspected that arginine vasopressin may be involved in the thermoregulatory response to chlorpyrifos. To this end, core temperature and motor activity of male and female Sprague‐Dawely rats were monitored before and after treatment with the corn oil vehicle or chlorpyrifos (15 mg/kg in females; 30 mg/kg in males; oral) concomitant with injection of a saline vehicle or a type 1 arginine vasopressin antagonist (20 μg/kg in females; 30 μg/kg in males; intraperitoneally). Rats dosed with chlorpyrifos and saline underwent a 2–3 ° reduction in core temperature >50% decrease in motor activity. The V1 antagonist attenuated the hypothermic effect of chlorpyrifos in both sexes. Chlorpyrifos‐induced inhibition in motor activity was unaffected by the V1 antagonist. In another experiment, the V1 antagonist (30 μg/kg) was co‐administered with saline or 0.2 mg/kg oxotremorine, a muscarinic agonist that stimulates a heat loss response and partially mimics the effects of chlorpyrifos. The V1 antagonist attenuated the hypothermic effect of oxotremorine in both sexes. Plasma arginine vasopressin levels were determined in male rats 3 hr after corn oil or 30 mg/kg chlorpyrifos. There was no significant effect of chlorpyrifos on plasma levels of arginine vasopressin. That the V1 antagonist blocked the hypothermic effect of chlorpyrifos suggests that the thermoregulatory response to chlorpyrifos is mediated by central and/or systemic vasopressin release. The lack of a significant increase in plasma vasopressin after chlorpyrifos suggests that localized release of vasopressin may be involved in the thermoregulatory response to chlorpyrifos.
Extracellular Vesicles in Cancer Metastasis: Potential as Therapeutic Targets and Materials

Field: Medicine (Health Sciences)

The vast majority of cancer-related deaths are due to metastasis of the primary tumor that develops years to decades after apparent cures. However, it is difficult to effectively prevent or treat cancer metastasis. Recent studies have shown that communication between cancer cells and surrounding cells enables cancer progression and metastasis. The comprehensive term “extracellular vesicles” (EVs) describes lipid bilayer vesicles that are secreted to outside cells; EVs are well-established mediators of cell-to-cell communication. EVs participate in cancer progression and metastasis by transferring bioactive molecules, such as proteins and RNAs, including microRNAs (miRNAs), between cancer and various cells in local and distant microenvironments. Clinically, EVs functioning as diagnostic biomarkers, therapeutic targets, or even as anticancer drug-delivery vehicles have been emphasized as a result of their unique biological and pathophysiological characteristics. The potential therapeutic effects of EVs in cancer treatment are rapidly emerging and represent a new and important area of research. This review focuses on the therapeutic potential of EVs and discusses their utility for the inhibition of cancer progression, including metastasis.
The Weaver Wasp: Spinning Fungus into a Nest

Field: Agricultural and Biological Sciences (Life Sciences)

ABSTRACT Wasp nests range from simple to complex structures made of paper or mud. Here, we show that a Neotropical wasp of the genus Nitela builds its nest entirely by weaving endophytic fungal hyphae and spider silk harvested from the leaves growing in the understory of the rain forest in French Guiana.
COMMUNICATIVE PURPOSE AND FUNCTIONS OF MODERN SOCIAL ADVERTISING

Field: Arts and Humanities (Social Sciences)

The article is devoted to the study of social advertising as a special type of French advertising discourse, namely, to the definition of the communicative purpose and functions inherent to advertising discourse. Special attention was paid to the development of the classification of communicative goals of the advertising message and the definition of its functions in social advertising. Having studied the message of modern social advertising, we classified its communicative purpose as follows: 1) attracting attention or changing the attitude of the public to a certain problem; 2) call to change the behavioural model of society; 3) promotion of a certain way of life; 4) encouragement to specific actions; 5) forming of public opinion / social consciousness; 6) humanisation of society and its involvement in social processes. It is worth noting that depending on the type of communicative purpose of the advertising message, French social advertising performs the following functions: informative, promotional, explanatory (interpretive), preventive, economic (incentive to pay taxes), educational (educational), persuasive. Usually, one advertising message performs several functions at the same time, since the informative function in social advertising is often combined with a promotional or preventive function, the educational function with an interpretive function, and the persuasive function can be combined with any of the listed functions. The analysis of French social advertising messages showed that the communicative purpose of an advertising message and its functions are closely related, in other words, the functions of a social advertising message depend on its communicative purpose. To be as effective as possible in the process of social communication, advertising slogans must precisely combine language form, pragmatic instructions and communicative functions.
INFINITE ARRAYS AND RECOGNIZABILITY

Field: Computer Science (Physical Sciences)

In this paper, the concept of local languages is extended to infinite arrays and ωω-local languages are defined. ωω-recognizable languages of infinite arrays accepted by online tesselation automata are considered. Properties of these languages are studied. The notion of Muller recognizability is extended to infinite arrays. This is related to acceptance of infinite arrays by online tesselation automata.
Deep Learning-Based Classification Study of Hidden Violations in Oil Well Engineering Field

Field: Computer Science (Physical Sciences)

Abstract Hidden violations are prevalent in complex activities on onshore drilling platforms, posing significant risks to safe operations. Despite ongoing QHSE compliance efforts, unsafe behaviors persist among personnel. This study presents a deep learning-based classification model that automatically categorizes hidden hazard and violation descriptions. Each classification corresponds to a specific negative score, which is ultimately reflected in employees' job performance. The goal is to enhance safety awareness and foster a stronger QHSE culture among well personnel. This study utilizes over 20,000 data points, with the bge-large-zh semantic vector model fine-tuned to classify hidden defects into eight categories, including defects in well control facilities and special equipment. Violations are categorized into seven major groups and 20 subcategories, such as illegal operations, unauthorized commands, and labor discipline violations. The model achieves a classification accuracy of 95%, significantly reducing the need for manual inspection. By automating the identification of hidden hazards, the model provides technical support for the QHSE safety supervision platform and offers engineers new insights into applying fine-tuned semantic vector models for real-time risk assessment in drilling operations.
A neoschumpeterian review of the impact of corruption on competitiveness and foreign direct investment

Field: Economics, Econometrics and Finance (Social Sciences)

En los países donde el gobierno fomenta las “donaciones” y los “obsequios” de empresas privadas, las empresas de IED tienen más probabilidades que sus contrapartes nacionales de participar en formas corruptas de influencia política, conocidas como capturas estatales. Diferentes tipos de inversores extranjeros participan en tipos particulares de corrupción, dependiendo de la ventaja competitiva que obtengan de ello. Las empresas de IED con socios locales tienen más probabilidades de participar en la captura del estado. Las empresas multinacionales más grandes con sede en el extranjero dependen mucho menos de la captura del Estado, pero es más probable que recurran a la corrupción política y al soborno (sobornos) en sus relaciones con Estados extranjeros. \n \nAunque con bastante frecuencia los inversores extranjeros directos pueden afirmar que son objeto de sobornos específicos de los gobiernos locales, se ha descubierto que no hay pruebas de que las empresas de IED paguen sobornos generales más elevados que las empresas nacionales, aunque es más probable que participen en actividades específicas. formas de corrupción. Además, se ha demostrado que los inversores extranjeros en realidad obtienen altos rendimientos de actos corruptos, lo que significa que las empresas de IED en realidad reciben una cantidad sustancial de las rentas de la corrupción. Por lo tanto, esta evidencia rechaza la opinión de que los inversores extranjeros se ven obligados a pagar sobornos. Según la evidencia recopilada en una encuesta realizada en 1999-2000, las leyes para prevenir el soborno, como la FCPA de EE.UU. y la Convención de la OCDE sobre el soborno de funcionarios públicos extranjeros, no han llevado a estándares más altos de conducta corporativa entre los inversores extranjeros. \n​