jimnoneill/paper-to-field-training huggingface dataset:
High hydroxycinnamic acids contents in fennel honey produced in Southern Italy

Field: Agricultural and Biological Sciences (Life Sciences)

A total of 122 honey samples (Apis mellifera ssp. Ligustica) collected from Southern Italy were examined for floral identification by melissopalynological examination and for polyphenols detection by an LC–ESI-OrbitrapTM -MS/MS method. The melissopalynological examination confirmed all the samples examined as fennel (Foeniculum vulgare) unifloral variety. The analytical method carried out for polyphenols detection showed satisfactory linearity and recovery values, achieved during the validation of the method. Very high amounts of flavonols (kaempferol and quercetin) and hydroxycinnamic acids (caffeic acid, chlorogenic acid and ferulic acid), were found in all the samples examined. Among the hydroxycinnamic acids group, caffeic acid showed the highest mean contents (865.90 ± 67.07 µg/kg). The results of this work confirmed the high presence of phenolic acids with strong free radical–scavenging activity in fennel products such as honey, suggesting their use to reduce oxidative stress.
Macromodelling of analogue circuits using VHDL-AMS

Field: Computer Science (Physical Sciences)

The purpose of this project is to implement the top down design system by using VHDL-AMS. VHDL-AMS, an analogue hardware description language and an extension to Very High-Speed Integrated Circuits (VHSIC) Hardware Description Language (VHDL), is capable of modelling analogue models by using additional language features, and the heritage of digital modeling capability.
Clinical outcome of interval cadaveric renal transplantation in cardiac allograft recipients.

Field: Medicine (Health Sciences)

The introduction of cyclosporine into widespread clinical use has resulted in improved patient survival following cardiac transplantation. As a result of increased numbers of cardiac transplants, the inherent nephrotoxicity of cyclosporine, and prolonged patient survival, cardiac transplant recipients commonly present with renal dysfunction. In the subgroup who ultimately develop end-stage renal disease (ESRD), therapeutic options include renal transplantation. However, the clinical course associated with this treatment modality is unknown. From 1980 to 1993, 430 cardiac transplants were performed with cyclosporine-based immunosuppression at the Standard University Medical Center. Fourteen (3.3%) patients developed ESRD, requiring chronic dialysis or renal transplantation. The cause of ESRD was cyclosporine nephropathy (13/14; 93%) and glomerulonephritis (1/14; 7%). The average time interval to the development of ESRD was 82 +/- 42 months. Nine patients underwent renal transplantation. During the period of followup (38 +/- 27 months; range 6-89 months) after renal transplantation, cardiac function remained stable. There were no episodes of primary nonfunction of the renal allograft. Patient and renal allograft survival was 89% at both 1 and 3 years after renal transplant. Average serum creatinine was 1.3 +/- 0.6 mg/dl at 1 year and 1.6 +/- 0.8 mg/dl at 3 years post-transplant. The incidence of infectious complications was not statistically different when compared to that of the heart transplant controls and that of a group of cadaveric renal transplant controls (n = 20). Surprisingly, the incidence of renal allograft rejection in the heart transplant patients was 10-fold less than that of the renal transplant controls (0.006 +/- 0.02/patient-year vs. 0.062 +/- 0.05/patient-year; p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Exactly marginal parafermions

Field: Physics and Astronomy (Physical Sciences)

We describe several families of non-unitary coset conformal field theories\nthat possess truly marginal couplings. These generalize the known examples of\nWess-Zumino-Witten models on supergroups such as PSU(n|n) or OSP(2n+2|2n). Our\nextension includes coset space sigma models, affine Toda theories or\nGross-Neveu models which are believed to arise in certain limits.\n
Telemedicine as a Tool to Improve Medicine Adherence in Patients with Affective Disorders – A Systematic Literature Review

Field: Health Professions (Health Sciences)

Maren Leiz,1,* Nils Pfeuffer,1,* Laura Rehner,2 Ulrike Stentzel,1 Neeltje van den Berg1 1Institute for Community Medicine, University Medicine, Greifswald, Germany; 2Institute for Nursing Science and Interprofessional Learning, University Medicine, Greifswald, Germany*These authors contributed equally to this workCorrespondence: Nils Pfeuffer, Institute for Community Medicine, Ellernholzstr. 1– 2, Greifswald, 17487, Germany, Tel +49 3834 / 86 76 18, Email nils.pfeuffer@med.uni-greifswald.deAbstract: Affective disorders are a common psychological impairment. A major problem with respect to treatment is medication non-adherence. eHealth interventions are already widely used in the treatment of patients living with affective disorders. The aim of this systematic literature review is to obtain the current scientific evidence to eHealth as a tool to improve medication adherence in patients with affective disorders. A systematic search was performed across PubMed, Cochrane Library, Web of Science and PsycInfo. Studies in English and German published between 2007 and 2020 were included. The review followed the PRISMA guidelines and were performed with the CADIMA online tool. A total of 17 articles were included in this review. Eleven studies were randomized controlled trials, two were controlled clinical trials, and four had a pre-/post-design. Three different types of interventions could be identified: internet-based self-management programs (n=4), multi-faceted interventions addressing different dimensions of medication adherence (n=4), and single-faceted interventions (n=9) comprising four mobile interventions and five telehealth interventions. Eleven interventions addressed patients with (comorbid) depressions and six addressed patients with bipolar disorders. Six interventions showed a statistically significant positive effect on medication adherence. None of the studies showed a statistically significant negative effect. All interventions which had a statistically significant positive effect on medication adherence involved personal contacts between therapists and patients. All included eHealth interventions are at least as effective as control conditions and seems to be effective for patients with depression as well as with bipolar disorders. Personal contacts seem to improve the effectiveness of eHealth interventions. eHealth interventions are an effective way to improve medication adherence in patients with affective disorders. In rural or underserved regions, eHealth can supplement usual care interventions on medication adherence by expanding access. More analyses are needed in order to understand determinants for the effectiveness of eHealth interventions on medication adherence enhancement.Keywords: affective disorder, eHealth, medication adherence, medication nonadherence, compliance, noncompliance
Hypolipidemic Activities of Two Pentapeptides (VIAPW and IRWWW) from Miiuy Croaker (Miichthys miiuy) Muscle on Lipid Accumulation in HepG2 Cells through Regulation of AMPK Pathway

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

In this work, the hypolipidemic activities of two pentapeptides (VIAPW and IRWWW) from miiuy croaker (Miichthys miiuy) muscle on oleic acid (OA)-induced lipid accumulation in HepG2 cells were investigated. VIAPW and IRWWW could significantly inhibit lipid accumulation induced by OA and decreased intracellular levels of intracellular triglyceride (TG) and total cholesterol (TC) in a dose-effect dependence manner. At the concentration of 100 μm, the TG levels of VIAPW (0.201 ± 0.006 mm) and IRWWW (0.186 ± 0.005 mm) were very (p < 0.01) and extremely (p < 0.001) significantly lower than those (0.247 ± 0.004 mm) of the OA model group; the levels of TC of VIAPW (45.88 ± 0.74 μg/mg protein) and IRWWW (41.02 ± 0.14 μg/mg protein) were very (p < 0.01) and extremely (p < 0.001) significantly lower than that (53.45 ± 0.10μg/mg protein) of the OA model group (p < 0.01). The hypolipidemic mechanisms of VIAPW and IRWWW were to down-regulate the expression levels of genes of SREBP-1c, SREBP-2, FAS, ACC, and HMGR in lipid synthesis and to up-regulate the expression levels of genes of PPARα, ACOX-1, and CPT-1 in lipid oxidation. These results suggested that VIAPW and IRWWW could play their hypolipidemic activities in HepG2 cells through regulation of AMPK pathway and act as hypolipidemic nutrient ingredients applied in public healthy and functional foods.
Research on the Connotation of Urban Carrying Capacity

Field: Environmental Science (Physical Sciences)

With the rapid growth of the world population and the decrease of the cultivated land area year by year, people begin to re-examine and evaluate the carrying capacity of our land.The article absorbed the idea of sustainable development, and finished the interpretation of the connotation of urban carrying capacity from the starting point of urban carrying capacity.The author thinks that the urban carrying capacity is the number of people that a city can carry and the intensity of various human activities under a certain level of economy, society, environment and resources.From the perspective of carrying status, urban carrying capacity is an organic combination of economic carrying capacity, social carrying capacity, environmental carrying capacity and resource carrying capacity.
Hell On Earth: A Modern Day Inferno in Cormac McCarthy's The Road

Field: Arts and Humanities (Social Sciences)

Cormac McCarthy's The Road and Dante's the Inferno contain textual and thematic comparisons. While the Inferno creates a world that exhibits the worst fears of the medieval Catholic subconscious of Dante's time, The Road paints a world of the darkest fears of the current American subconscious. Both texts reflect a critical dystopia that speculates on human spirituality and offers a critique of society through a tour of sin and suffering in a desolate setting.
MODEL OF INCREASING THE COMPETITIVENESS OF ENTERPRISES IN THE CONTEXT OF EUROPEAN INTEGRATION DEVELOPMENT

Field: Business, Management and Accounting (Social Sciences)

The paper investigates the enhancement of enterprise competitiveness within the framework of European integration. Ukrainian enterprises must adapt to strict EU standards, high market competition, and rapid digitalization, requiring the mobilization of internal capabilities. The study aims to develop an integrative model that unites key internal and external competitiveness factors. A combination of systemic, structural-functional, and modeling approaches was applied to ensure analytical coherence. The resulting graphical model illustrates the interaction between innovation, human capital, resources, digital transformation, marketing, and institutional adaptation. The model supports strategic planning and performance assessment. Its originality lies in offering a unified framework for sustainable enterprise competitiveness in integration conditions.
Disentangled Cross-modal Fusion for Event-Guided Image Super-resolution

Field: Computer Science (Physical Sciences)

Event cameras detect the intensity changes and produce asynchronous events with high dynamic range and no motion blur. Recently, several attempts have been made to superresolve the intensity images guided by events. However, these methods directly fuse the event and image features without distinguishing the modality difference and achieve image superresolution (SR) in multiple steps, leading to error-prone image SR results. Also, they lack quantitative evaluation of real-world data. In this article, we present an end-to-end framework, called event-guided image (EGI)-SR to narrow the modality gap and subtly integrate the event and RGB modality features for effective image SR. Specifically, EGI-SR employs three crossmodality encoders (CME) to learn modality-specific and modality-shared features from the stacked events and the intensity image, respectively. As such, EGI-SR can better mitigate the negative impact of modality varieties and reduce the difference in the feature space between the events and the intensity image. Subsequently, a transformer-based decoder is deployed to reconstruct the SR image. Moreover, we collect a real-world dataset, with temporally and spatially aligned events and color image pairs. We conduct extensive experiments on the synthetic and real-world datasets, showing EGI-SR favorably surpassing the existing methods by a large margin.
Overproduction, Purification and Characterization of the Cellulose‐Binding Domain of the Erwinia Chrysanthemi Secreted Endoglucanase EGZ

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

EGZ is the major endoglucanase secreted by Enwinia chrysanthemi. Functional characterization indicates that it is made of a catalytic N‐terminal domain linked to a C‐terminal cellulose‐binding domain (CBD) by a Ser/Thr‐rich linker. A chimeric plasmid, in which the CBD‐encoding region was fused downstream of the ompA signal sequence, was constructed and introduced into Escherichia coli. This allowed for the production of processed and disulfide‐bonded CBD, mostly recovered from the culture supernatant of E. coli. One‐dimensional NMR analysis of the purified CBD reveals that it folds into a well‐structured domain. Moreover, comparison with the one‐dimensional NMR analysis of full‐length EGZ strongly suggests that the CBD folds autonomously, providing experimental support for the existence of domains of EGZ.
Supplementary Figures and Tables from Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>Supplementary Figures and Tables - Figure S1. RNF40 somatic copy number alterations in a cohort of 579 HGSOC cases from The Cancer Genome Atlas (TCGA). Heterozygous loss of RNF40 is present in 36% of HGSOCs. Figure S2A. H2Bub1 stain intensity dot plot. Figure S2B. Distribution of H2Bub1 immunoreactivity (% positive cells). Figure S2C. Immunohistochemical analysis of Total H2B and H2Bub1 levels in invasive high-grade serious ovarian cancer. Figure S3. Stable RNF20 and H2Bub1 depletion escalates oncogenic behavior in FTSEC cell lines. Figure S4. Transient RNF20 and H2Bub1 depletion escalates oncogenic behavior in FTSECs. Figure S5. RNF20-depletion changes chromatin accessibility and redistributes open chromatin. Figure S6. RNF20-depletion changes chromatin accessibility and alters gene expression of immune signaling pathways in FTSEC cells. Figure S7. RNF20 and H2Bub1 deficiency alters the levels of cytokines. Figure S8. Representative images for RNA in situ hybridization of IL6 expression in FFPE tumor and normal tissue sections. Supplementary Table 1. Antibody information and staining conditions for immunohistochemistry (IHC).</p>
Fluorinated Building Blocks. The Discovery of a Stable Difluoroallenyl Indium and the Synthesis of gem-Difluoroallenyl and -propargyl Synthons in Aqueous Media.

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionFluorinated Building Blocks. The Discovery of a Stable Difluoroallenyl Indium and the Synthesis of gem-Difluoroallenyl and -propargyl Synthons in Aqueous Media.ZhiGang Wang and Gerald B. HammondCite this: J. Org. Chem. 2000, 65, 24, 8406Publication Date (Web):November 3, 2000Publication History Published online3 November 2000Published inissue 1 December 2000https://pubs.acs.org/doi/10.1021/jo004010uhttps://doi.org/10.1021/jo004010ucorrectionACS PublicationsCopyright © 2000 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views339Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (11 KB) Get e-Alertsclose Get e-Alerts
Telaah Pemikiran Nurcholish Madjid Terhadap Politik Identitas

Field: Arts and Humanities (Social Sciences)

This research aims to determine Nurcholish Madjid's political thinking style. This research is library research or library study using a philosophical and historical approach. The data sources used are primary and secondary data sources. Primary data sources in this research are books written directly by Nurcholish Madjid, as well as books that are relevant to the discussion, while secondary data in this research are relevant literature materials that discuss identity politics. The data collection method in this research uses direct quotation and indirect quotation methods. The data analysis technique used in this research is content analysis technique. The research results show that Nurcholish Madjid's political thinking style is characterized by inclusiveness, pluralism and universal Islamic values. Madjid believes that Islamic values ​​should be applied in social life without linking them to religious-based political parties. He also advocates democracy, human rights, and education that emphasizes tolerance and pluralism. Background to the emergence of the jargon "Islam yes, Islamic parties no". This is a concern. He believes that Islamic political parties tend to divide society and are used for short-term political interests by elites. According to Nurcholish Madjid, the relevance of the jargon "Islam Yes, Islamic Party No" to the phenomenon of identity politics in Indonesia is very significant. This jargon teaches the importance of pluralism and inclusiveness in politics, so that it can reduce polarization and sectarianism in society.
Fall and Spring Preplant Herbicide Applications Influence Spring Emergence of Glyphosate-Resistant Horseweed (Conyza canadensis)

Field: Agricultural and Biological Sciences (Life Sciences)

Horseweed ( Conyza canadensis ) is a common weed in no-till crop production systems. It is problematic because of the frequent occurrence of biotypes resistant to glyphosate and acetolactate synthase (ALS)-inhibiting herbicides and its ability to complete its life cycle as a winter or summer annual weed. Tactics to control horseweed while controlling other winter annual weeds routinely fail; herbicide application timing and spring emergence patterns of horseweed may be responsible. The objectives of this experiment were to (1) determine the influence of fall and spring herbicides with and without soil residual horseweed activity on spring-emerging glyphosate-resistant (GR) horseweed density and (2) evaluate the efficacy and persistence of saflufenacil on GR horseweed. Field studies were conducted in southern Indiana and Illinois from fall 2006 to summer 2007 and repeated in 2007 to 2008. Six preplant herbicide treatments were applied at four application timings: early fall, late fall, early spring, and late spring. Horseweed plants were counted every 2 wk following the first spring application until the first week of July. Horseweed almost exclusively emerged in the spring at both locations. Spring horseweed emergence was higher when 2,4-D + glyphosate was fall-applied and controlled other winter annual weeds. With fall-applied 2,4-D + glyphosate, over 90% of the peak horseweed density was observed before April 25. In contrast, only 25% of the peak horseweed density was observed in the untreated check by April 25. Starting from the initiation of horseweed emergence in late March, chlorimuron + tribenuron applied early fall or early spring, and spring-applied saflufenacil at 100 g ai/ha provided greater than 90% horseweed control for 12 wk. Early spring–applied saflufenacil at 50 g ai/ha provided 8 wk of greater than 90% residual control, and early spring–applied simazine provided 6 wk of greater than 90% control. When applied in late spring, saflufenacil was the only herbicide treatment that reduced horseweed densities by greater than 90% compared to 2,4-D + glyphosate. We concluded from this research that fall applications of nonresidual herbicides can increase the rate and density of spring emerging horseweed. In addition, spring-applied saflufenacil provides no-till producers with a new preplant herbicide for foliar and residual control of glyphosate- and ALS-resistant horseweed.
Phosphoproteomic Analysis of Synaptosomes from Human Cerebral Cortex

Field: Neuroscience (Life Sciences)

Protein phosphorylation is a crucial post-translational modification mechanism in the regulation of synaptic organization and function. Here, we analyzed synaptosome fractions from human cerebral cortex obtained during therapeutic surgery. To minimize changes in the phosphorylation state of proteins, the tissue was homogenized within two minutes of excision. Synaptosomal proteins were digested with trypsin and phosphopeptides were isolated by immobilized metal affinity chromatography and analyzed by liquid chromatography and tandem mass spectrometry. The method allowed the detection of residues on synaptic proteins that were presumably phosphorylated in the intact cell, including synapsin 1, syntaxin 1, and SNIP, PSD-93, NCAM, GABA-B receptor, chaperone molecules, and protein kinases. Some of the residues identified are the same or homologous to sites that had been previously described to be phosphorylated in mammals whereas others appear to be novel sites which, to our knowledge, have not been reported previously. The study shows that new phosphoproteomic strategies can be used to analyze subcellular fractions from small amounts of tissue for the identification of phosphorylated residues for research and potentially for diagnostic purposes.
Criminal Justice Barriers to Treatment of Opioid Use Disorders in the United States: The Need for Public Health Advocacy

Field: Health Professions (Health Sciences)

Expanding access to treatment of opioid use disorder (OUD) is central to addressing the US overdose mortality crisis. Numerous barriers to OUD treatment are encountered in criminal justice institutions and processes, with which people with OUD are disproportionately involved. OUD treatment access is severely limited in US corrections facilities, with few exceptions. Drug treatment courts, which in principle provide court-supervised treatment as an alternative to prison, have also unduly limited treatment options, particularly medication-assisted treatment. The voice and expertise of health professionals are urgently needed to remove these barriers and ensure that criminally accused persons are systematically linked to the care they need.