jimnoneill/paper-to-field-training huggingface dataset:
Conformer- and Alignment-Independent Model for Predicting Structurally Diverse Competitive CYP2C9 Inhibitors

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

A conformer- and alignment-independent three-dimensional structure-activity relationship (3D-QSAR) model has been derived that is based on flexible molecular interaction fields calculated in GRID and the subsequent description of these fields by use of alignment-independent descriptors derived in ALMOND. The training set consisted of 22 diverse and flexible competitive inhibitors of the drug-metabolizing enzyme CYP2C9 and generated a model with r(2) of 0.81 and q(2) of 0.62. The predicitive capacity of the model was externally evaluated with a test set of 12 competitive inhibitors and 11 out of 12 were predicted within 0.5 log unit. The most relevant points of interaction in the model correlated well to the amino acids involved in CYP2C9-substrate/inhibitor binding in the active site of a CYP2C9 homology model, further validating the mechanistic sense of our model. This approach offers the possibility to derive predicitve 3D-QSAR models without the need for an alignment rule for chemically diverse ligands and in the absence of target protein crystal structure information.
PUB1 Interacts with the Receptor Kinase DMI2 and Negatively Regulates Rhizobial and Arbuscular Mycorrhizal Symbioses through Its Ubiquitination Activity in Medicago truncatula

Field: Agricultural and Biological Sciences (Life Sciences)

The E3 ubiquitin ligase PUB1 is a common negative regulator for both rhizobial and arbuscular mycorrhizal symbioses and interacts with a key receptor kinase.
African American Women's Unique Divorce Experiences

Field: Social Sciences (Social Sciences)

Abstract The qualitative study explored African American working women's pre-divorce, divorce and postdivorce experiences. A total of thirty divorced women were interviewed face-to-face by a social worker in a Member's Assistance Program where the women had received free legal and social work services. The findings demonstrate that the women face emotional and financial problems as a result of low salaries, lack of child support and lack of alimony. The consequences of divorce are usually compounded by problems of discrimination. Cultural factors, such as their strong belief in God, close family relationships, strong work ethic and strong achievement orientation (50% returned to college), helped them adjust very well to the divorce.
How Gentle Must Violence Against Women Be in Order to Not Be Violent? Rethinking the Word “Violence” in Obstetric Settings

Field: Social Sciences (Social Sciences)

With the growing concern of human rights in health, the word “violence” is being used to describe apparent disrespectful treatment received by women by either health care practitioners or health care systems. As the definition of violence in health care settings broadens, questions arise over the impact of the term in describing objective reality. Specifically, does use of the term “violence” inadvertently disempower the women that it is meant to empower? This article explores the changing use of the term “violence” and specifically draws on evidence in a South African labor ward, where phenomena such as silence and limited social support have cultural underpinnings that contradict labels of structural or obstetric violence. As global research on obstetric violence in disadvantaged communities grows, choice of terminology will become more important in filtering results into medical policy and practice.
A Critical Assessment of Methods for Analysis of Social Welfare Impacts of Genetically Modified Crops: a Literature Survey. Working Paper Mansholt Graduate School MWP-27, Wageningen University. [Review of ex-ante and ex-post assessments of agriculture bio

Field: Arts and Humanities (Social Sciences)

1 Working Papers are interim reports on work of Mansholt Graduate School (MGS) and have received only limited reviews1. Each paper is refereed by one member of the Editorial Board and one member outside the board. Views or opinions expressed in them do not necessarily represent those of the Mansholt Graduate School. The Mansholt Graduate School’s researchers are based in three departments: ‘Social
Empowering Mosque Cooperatives for Development of The Ummah

Field: Social Sciences (Social Sciences)

The poverty rate in Malaysia is still worrisome despite being at low rate. Various solutions have been made, including the movement of mosque cooperatives as the multi-function business centre to help and empower the community within via several solutions, such as provide financing, investment centre and halal food centre for Muslims. However, there is a number of community members that are being left out from enjoying the benefits and aids provided, and their lives are getting worse financially, especially during the pandemic of Covid-19. This article aims to examine the role of mosque cooperatives in economic empowerment of the ummah. The roles will be examined from the perspectives of business networking, and the information and governance systems of the mosque cooperatives. The study adopted the FGD with the key players related to mosque cooperatives, including authorities. The data collected was analysed using NVIVO. The results of the discussion were categorised into four main themes; acceptance, initiatives, action plans and key players. The participants agreed with the role of mosque cooperatives in empowering the ummah via various initiatives that have been taken place. Despite that, the problems arising within the mosque cooperatives have been identified and a few action plans have been discussed to rectify the arising matters together with the involvement of key players for the success of mosque cooperatives. The integration of cooperatives through mosques is a powerful tool in empowering the economic resilience of the community. The involvement of regulators, religious leaders and the community around the mosque towards the empowerment of the community within, especially the poor can help in organizing their lives better. The economic empowerment via mosque cooperatives is an initiative based on the local community around the mosque, thus mosque is not only a worship centre, but also a center for community’s economic empowerment.
Cytokines and Metabolic Factors Regulate Tumoricidal T-Cell Function During Cancer Immunotherapy

Field: Medicine (Health Sciences)

Recent advances in cancer biology and genetics have fostered precision therapies targeting tumor-specific attributes. Immune-based therapies that elicit cytolytic T cells (CTL) specific for tumor antigens can provide therapeutic benefit to cancer patients, however, cure rates are typically low. This largely results from immunosuppressive mechanisms operating within the tumor microenvironment, many of which inflict metabolic stresses upon CTL. Conversely, immunotherapies can mitigate specific metabolic stressors. For instance, dual costimulation immunotherapy with CD134 (OX40) plus CD137 (4-1BB) agonists appears to mediate tumor control in part by engaging cytokine networks that enable infiltrating CTL to compete for limiting supplies of glucose. Future efforts combining modalities that endow CTL with complimentary metabolic advantages should improve therapeutic efficacies.
Easing Internet access of health information for elderly users

Field: Health Professions (Health Sciences)

Elderly users are increasingly becoming active consumers of Internet technologies. Developing websites dedicated to this user group presents several design issues (such as that of ‘design for all’, participatory design, patient empowerment and cognitive usability assessment methods). SeniorGezond is a health information resource currently under development. It aims to support elderly users in their search and access of appropriate information in the area of fall incidences. The current development of SeniorGezond provides a useful illustration on how design issues can be addressed and applied in a practical setting.
Profile of Service Use and Barriers to Access among Brazilian Children and Adolescents with Autism Spectrum Disorders

Field: Health Professions (Health Sciences)

Delayed diagnosis and a lack of adequate care for people with autism spectrum disorder (ASD) are related to worse outcomes and quality of life. This study aimed to identify the profile of service use, barriers to access care, and factors related to those barriers in Brazilian families with children with ASD. A total of 927 families with ASD children (3-17 years) from five Brazilian regions completed an online version of the Caregivers Needs Survey. Results showed that the most used services were behavioral interventions and pharmacotherapy, while the most used professionals were neurologists, nutritionists, speech therapists, psychiatrists, psychologists, and pediatricians. The main barriers included waiting lists, costs, and the absence of services or treatment. Service use varied according to age, the region of residence, the type of health care system used, and the parents/caregivers' education. Access to behavioral interventions was more frequent among users of the private system/health insurance and families whose caregivers had higher education. The absence of specialized services/treatments was less frequent among residents of state capitals and families whose caregivers had higher levels of education. This study highlights how families with children/adolescents with ASD in Brazil face significant barriers to access care related to sociodemographic factors.
Control of Cattail and Bulrush by Cutting and Flooding

Field: Agricultural and Biological Sciences (Life Sciences)

Cutting emergent vegetation represents an artificial technique not widely used, despite its effectiveness in inhibiting revegetation and enhancing emergent vegetation-water interspersion. Cutting procedures, implements, and size and configuration of cut areas differed among study areas and are described below for each area. Regeneration of cattail and bulrush was investigated at M. Milligan Creek and Kapakoskasewakak Lake, respectively. R. Murkin Henry and Ward and Sale and Wetzel discussed the possible mechanism by which cutting and subsequent flooding of cattail stubble results in its decreased regeneration. Post-growing season cutting of cattail and bulrush with subsequent flooding during the growing season appears to be an effective control method for these and possibly other emergent plant species. In several marshes in western Canada, the authors evaluated regeneration of common cattail, tule bulrush, and softstem bulrush following post-growing season cutting and subsequent spring-summer flooding as a method of control.
Real options valuation applied to dynamic transmission expansion planning

Field: Decision Sciences (Social Sciences)

Transmission expansion planning (TEP) is a complex problem where building a new line involves a long permitting process of around 10 years. Therefore, transmission expansion must anticipate the evolution of uncertainties, particularly those derived from changes in the capacity and location of new generating facilities. As it is not possible to request permits for all possible lines, priorities must be established. We develop a formulation to use real options valuation to evaluate the potential benefit of candidate lines and thereby identify priority projects. We present a feasible representation of optionality in TEP projects and propose a tractable evaluation of option value. The proposed technique identifies the candidate transmission lines with the highest potential, as well as their main value drivers. This is implemented in a realistic large-scale case study based on the Spanish system.
Data from Histone Deacetylase Inhibitor Panobinostat Induces Clinical Responses with Associated Alterations in Gene Expression Profiles in Cutaneous T-Cell Lymphoma

Field: Medicine (Health Sciences)

<div>Abstract<p><b>Purpose:</b> Histone deacetylase inhibitors can alter gene expression and mediate diverse antitumor activities. Herein, we report the safety and activity of the histone deacetylase inhibitor panobinostat (LBH589) in cutaneous T-cell lymphoma (CTCL) and identify genes commonly regulated by panobinostat.</p><p><b>Experimental Design:</b> Panobinostat was administered orally to patients with CTCL on Monday, Wednesday, and Friday of each week on a 28-day cycle. A dose of 30 mg was considered excessively toxic, and subsequent patients were treated at the expanded maximum tolerated dose of 20 mg. Biopsies from six patients taken 0, 4, 8, and 24 h after administration were subjected to microarray gene expression profiling and real-time quantitative PCR of selected genes.</p><p><b>Results:</b> Patients attained a complete response (<i>n</i> = 2), attained a partial response (<i>n</i> = 4), achieved stable disease with ongoing improvement (<i>n</i> = 1), and progressed on treatment (<i>n</i> = 2). Microarray data showed distinct gene expression response profiles over time following panobinostat treatment, with the majority of genes being repressed. Twenty-three genes were commonly regulated by panobinostat in all patients tested.</p><p><b>Conclusions:</b> Panobinostat is well tolerated and induces clinical responses in CTCL patients. Microarray analyses of tumor samples indicate that panobinostat induces rapid changes in gene expression, and surprisingly more genes are repressed than are activated. A unique set of genes that can mediate biological responses such as apoptosis, immune regulation, and angiogenesis were commonly regulated in response to panobinostat. These genes are potential molecular biomarkers for panobinostat activity and are strong candidates for the future assessment of their functional role(s) in mediating the antitumor responses of panobinostat.</p></div>
A Public Health Perspective on End of Life Care

Field: Health Professions (Health Sciences)

PART I: INTRODUCTION 1. Applying a public health perspective in end-of-life care PART II: CLINICAL AND SOCIAL CONTEXT OF DEATH AND DYING 2. Place of death and end-of-life care 3. Circumstances of death and dying 4. End-of-life decisions 5. Economic and health related consequences of individuals caring for terminally ill cancer patients in Canada PART III: END-OF-LIFE CARE: PROVISION, ACCESS, AND CHARACTERISTICS 6. Aggressive treatment and palliative care at the end of life 7. Access to palliative care 8. Communication between patient and caregiver PART IV: END-OF-LIFE CARE SETTINGS 9. Palliative care in primary care 10. Palliative care in institutional long-term care settings 11. Palliative care in hospitals PART V: INEQUALITIES AT THE END OF LIFE: UNDERSERVED GROUPS 12. Non-cancer patients 13. Palliative care for the older adult 14. A public health framework for pediatric palliative and hospice care 15. End-of-life care for patients with intellectual disabilities 16. End-of-life care for people who live in rural or remote areas versus those who live in urban areas 17. Social inequalities at the end of life PART VI: END-OF-LIFE CARE POLICIES 18. Design, implementation, and evaluation of palliative care programs and services with a public health who perspective 19. Public health policy regarding end-of-life care in sub-Saharan Africa 20. Palliative care in the global context: understanding policies to support end-of-life care 21. The importance of family carers in end-of-life care: a public health approach PART VII: CONCLUSION 22. Conclusions
Characteristics of 15 Subjects Affected by IgD Multiple Myeloma and the Key Role of the Laboratory in Diagnosis: A Retrospective Study Report and Literature Review

Field: Medicine (Health Sciences)

Immunoglobulin D (IgD) myeloma represents an uncommon subtype of multiple myeloma (MM), accounting for 1–2% of cases. Subjects affected by IgD MM have been demonstrated to have an inferior outcome and survival compared to those with other MM subtypes. A retrospective study was conducted on 15 patients (9 males and 6 females) diagnosed from 2008 to 2022 with IgD MM, in order to investigate the clinical and biochemical features at the moment of diagnosis, cytogenetic alterations, and survival times. The median age was 69 years, and higher frequencies of bone lesions, renal impairments, Bence–Jones proteinuria, and increased serum LDH were observed. Serum calcium levels were in the reference ranges. In the assessment of protein electrophoresis patterns, nine patients had a serum monoclonal protein that was not detectable. A cytogenetic analysis via fluorescence in situ demonstrated that the most common abnormalities were the deletion of 13q and IGH rearrangements. Patients treated with new chemotherapeutic drugs (immunomodulators, proteasome inhibitors), with or without autologous stem cell transplantation presented a higher median survival. The fundamental role of the laboratory in monoclonal IgD detection and the monitoring and studying of IgD MM cases enhances the knowledge of this disease, thus improving patient outcomes.
A unique case report of 2–cm-long fishbone induced acute suppurative thyroiditis

Field: Medicine (Health Sciences)

Acute suppurative thyroiditis (AST) is an infectious disease of the thyroid gland caused by bacterial, fungal, and parasitic organisms.Its diagnosis is often delayed, which may lead to life-threatening hazards.This study presents a unique case of foreign matter induced AST who presented as a normal AST case in an adult female.After the antibiotics treatment, when the pain symptom released and the vital signs were normal, surprisingly, CT scan and ultrasound revealed a foreign matter in the patient's thyroid, and thus an operation was conducted.A 2-cm-long fishbone was discovered in the thyroid tissue.This particular case was unique due to fact that the infection was induced by a fishbone piercing across the thyroid gland.Since thyroidectomy should be promptly performed for such a case, the consideration of foreign mattes induced AST should be borne in mind for discrimination diagnosis.
Retrospective Serosurvey of Three Porcine Coronaviruses among the Wild Boar (Sus scrofa) Population in the Campania Region of Italy

Field: Veterinary (Health Sciences)

The growing interest in porcine coronaviruses (CoVs) is due to both their negative effect on the swine industry and their propensity to mutate and overcome host barriers. Since information on CoVs in wild boar (Sus scrofa) is limited, especially in Italy, a serosurvey was conducted to assess the epidemiologic situation in the Campania region and to clarify the role of wild boar as reservoirs for enteric (porcine epidemic diarrhea virus [PEDV], transmissible gastroenteritis virus [TGEV]) and respiratory (respiratory coronavirus [PRCV]) swine CoVs. During the 2016-17 hunting season, serum samples were collected from 444 wild boars and tested for antibodies to enteric (PEDV, TGEV) and respiratory (PRCV) porcine CoVs by enzyme-linked immunosorbent assay. The highest seroprevalence in wild boars was for PEDV, with a positivity of 3.83% (95% confidence interval [CI] 2.05-5.6), whereas very low seroprevalences were found for TGEV and PRCV (0.67% positivity; 95% CI 0-1.44 in both cases). There was no statistical association between seropositivity to CoVs, sex, and location, whereas the prevalence of seropositive animals was positively correlated with young age (0-12 mo old). Our data confirm the presence of CoVs in wild boars in the Campania region. Our data are in agreement with the results of similar studies from other European countries, which attribute a minor role to wild boar in the transmission of these infections to domestic pigs. Our results suggest that continuous serologic surveys are necessary to monitor wild animals and detect emerging threats to livestock and humans.
Credibility Logic and Policy Analysis

Field: Social Sciences (Social Sciences)

The early promise of positivistic-based policy analysis was based on the authority of “science.” A “scientific approach” could bring rationality and rigor to public policy-making. But with all this promise and confidence, the actual utilization of policy analysis by decision makers within the last decade has been dismal. The purpose of this article is to suggest that policy analysts need not cling to scientific pretensions to bring some rationality and rigor to policymaking. This article introduces a “credibility model” in which policy analysts bring to the policymaker insights not available from the fund of ordinary knowledge, experience, and intuition that policymakers themselves contribute.
International and Local Lenders of Last Resort in a small open economy with aggregate risk

Field: Economics, Econometrics and Finance (Social Sciences)

In a two-currency, fixed exchange rates version of the Bryant- Diamond and Dybvig, small open economy model with aggregate liquidity shocks I study the role of an international and a local lenders of last resort in both implementing the first best allocation and preventing self fulfilling bank runs. The first best allocation implies that perfect insurance against aggregate liquidity risk, contrary to the partial suspension of convertibility result in Wallace (1988). It is shown that an international liqiudity-providing institution may implement the first best without runs. in contrast with the well-known result by Chang and Velasco (1998, 2000), when a local lender of last resort is needed. It is also shown that the International Lender of Last Resort in general prevent runs, independent of whether it implements the first best or not. An interim-date borrowing constrained social optimum is also characterized. A second best problem arises when borrowing constraints are introduced. Here Wallace’s (1990) partial suspension of convertibility is obtained. The first best results on implementation as well as the prevention of runs remains true also in the second best case.
© Hindawi Publishing Corp. ON A CLASS OF MEROMORPHIC p-VALENT STARLIKE FUNCTIONS INVOLVING CERTAIN LINEAR OPERATORS

Field: Mathematics (Physical Sciences)

p be the class of functions f(z) which are analytic in the punctured disk E ∗ = {z ∈ C: 0 &lt; |z | &lt; 1}. Applying the linear operator Dn+p defined by using the convolutions, the subclass n+p(α) of p is considered. The object of the present paper is to prove that n+p(α) ⊂ n+p−1(α). Since 0(α) is the class of meromorphic p-valent starlike functions of order α, all functions in n+p−1(α) are meromorphic p-valent starlike in the open unit disk E. Further properties preserving integrals and convolution conditions are also considered. 2000 Mathematics Subject Classification: 30C45.