jimnoneill/paper-to-field-training huggingface dataset:
Peer Review #3 of "The co-expression networks of differentially expressed RBPs with TFs and LncRNAs related to clinical TNM stages of cancers (v0.1)"

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Background: RNA-binding proteins (RBPs) play important roles in cellular homeostasis by regulating the expression of thousands of transcripts, which have been reported to be involved in human tumorigenesis.Despite previous reports of the dysregulation of RBPs in cancers, the degree of dysregulation of RBPs in cancers and the intrinsic relevance between dysregulated RBPs and clinical TNM information remains unknown.Furthermore, the co-expressed networks of dysregulated RBPs with transcriptional factors and lncRNAs also require further investigation.Results: Here, we firstly analyzed the deviations of expression levels of 1,542 RBPs from 20 cancer types and found that (1) RBPs are dysregulated in almost all 20 cancer types, especially in BLCA, COAD, READ, STAD, LUAD, LUSC and GBM with proportion of deviation larger than 300% compared with non-RBPs in normal tissues.(2) Up-and down-regulated RBPs also show opposed patterns of differential expression in cancers and normal tissues.In addition, down-regulated RBPs show a greater degree of dysregulated expression than up-regulated RBPs do.Secondly, we analyzed the intrinsic relevance between dysregulated RBPs and clinical TNM information and found that (3) Clinical TNM information for two cancer types-CHOL and KICH-is shown to be closely related to patterns of differentially expressed RBPs (DE RBPs) by co-expression cluster analysis.Thirdly, we identified ten key RBPs (seven downregulated and three up-regulated) in CHOL and seven key RBPs (five down-regulated and two up-regulated) in KICH by analyzing co-expression correlation networks.Fourthly, we constructed the co-expression networks of key RBPs between 1,570 TFs and 4,147 lncRNAs for CHOL and KICH, respectively.Conclusions: These results may provide an insight into the understanding of the functions of RBPs in human carcinogenesis.Furthermore, key RBPs and the co-expressed networks offer useful information for potential prognostic biomarkers and therapeutic targets for patients with cancers at the N and M stages in two cancer types CHOL and KICH.
Human Body Donation to Anatomy Laboratory for Educational Purpose: Legal, Ethical and Religious points of view

Field: Health Professions (Health Sciences)

Body donation refers to whole body donation for teaching and learning processes considered a noble act. In most religions, body donation law, organ transplantation act, tissue act permits body donation for medical and research purposes. In the current article, we have discussed mainly body donation laws of different countries along with necessary criteria that should be fulfilled by body donors along with the law that is necessary to claim the unclaimed bodies and give consent for the body donation. The article also includes a brief view regarding the religious perspective of major religions about human body donation.
Utilization of SVM, LSSVM and GP for Predicting the Medical Waste Generation

Field: Computer Science (Physical Sciences)

The prediction of wastes generated in the hospital will help their management for several activities like storage, transport and disposing. This chapter adopts Support Vector Machine (SVM), Least Square Support Vector Machine (LSSVM) and Genetic Programming (GP) in order to estimate the rate of medical waste generation. In the event of predicting the rate, type of hospital, capacity and bed occupancy has been used as inputs of SVM, LSSVM and GP. SVM is based on statistical learning theory, which provides an elegant tool for nonlinear system modeling. LSSVM is the re-formulation to the general SVM. GP, a best part of evolutionary algorithm and also the specification of Genetic Algorithm (GA). These SVM, LSSVM and GP have been used as the regression techniques. The results show the performance of the developed SVM, LSSVM and GP models were elegant and outstanding.
The chemical environment and structural ordering in liquid Mg-Y-Zn system: An ab-initio molecular dynamics investigation of melt for the formation mechanism of LPSO structure

Field: Materials Science (Physical Sciences)

In an effort to clarify the formation mechanism of LPSO structure in Mg-Y-Zn alloy, the chemical environment and structural ordering in liquid Mg-rich Mg-Y-Zn system are investigated with the aid of ab-initio molecular dynamics simulation. In liquid Mg-rich Mg-Y alloys, the strong Mg-Y interaction is determined, which promotes the formation of fivefold symmetric local structure. For Mg-Zn alloys, the weak Mg-Zn interaction results in the fivefold symmetry weakening in the liquid structure. Due to the coexistence of Y and Zn, the strong attractive interaction is introduced in liquid Mg-Y-Zn ternary alloy, and contributes to the clustering of Mg, Y, Zn launched from Zn. What is more, the distribution of local structures becomes closer to that in pure Mg compared with that in binary Mg-Y and Mg-Zn alloys. These results should relate to the origins of the Y/Zn segregation zone and close-packed stacking mode in LPSO structure, which provides a new insight into the formation mechanism of LPSO structure at atomic level.
Unsilencing HI (Stories) of Indo-Caribbean Women: Re-Writing and Re-Presenting Self and Community

Field: Arts and Humanities (Social Sciences)

This study unearths and explores stories of six Indo-Caribbean women (including myself) who live in Canada. We remembered, wrote, shared, and discussed in the context of a group writing practice. We met eleven times over a period of three months in 2012. \nIn addition, I collected family stories from my mother, her sister—my aunt, and my father’s brother—my uncle, as I sought to fill in huge spaces of not knowing with understandings. While there is no doubt that I have learnt a great deal about the lives of people in the Caribbean, and while there is still much that I may never know, this project has shown me that when I ask, there is a chance to know. Caribbean politics and culture have historically been a source of alienation for all of us, and yet we have a growing sense of belonging to the region. Our discussions spanned formal and traditional education, immigration, negotiations of race relations, gendered roles and stipulations of class and caste. \nMy analysis uncovered and formed new understandings about the lives of women in the study and Indo-Caribbean women more generally. I situate this study within a theoretical framework of colonial and postcolonial theory and history that integrates constructs of identity and memory; of Caribbean feminist discourse; and dominant traditional, cultural and political systems. \nThe stories, combined with interviews, are a gateway into histories that have been silenced. Silences, questions and gaps in this work are as important as the stories that were told. In this dissertation, I have discussed alienation and hardship as core aspects of experience for Indo-Caribbean women. In citing the scarcity of their published work, I ask, can mental abandonment of one’s environment be thought of as a form of silencing iii that is characteristic of formerly subjugated people? I consider the possibility of silence when there is nothing to applaud, and the silences of women as a form of resistance. As a work of remembrance and creative narration, this dissertation contributes to the growing body of literature and theoretical discourse of Indo-Caribbean women.
Motions and hydrodynamic loads of a ship advancing in oblique waves

Field: Engineering (Physical Sciences)

An analytical technique developed to estimate the respone motions and loads of a vessel is presented and the results are correlated with those of model tests and other methods. The stripwise computation technique is applied to the following hydrodynamic problems: wave-excited and motion-indiced forces and moments, wave loads on cross sections, and hydrodynamic pressure and relative motion. Extensive correlation analyses between theory and experiment, including full-scale comparisons, have been carried out for basic motions and loads and a number of derived responses in the cases of barges, in deep and shallow sea environments. The study shows that the predictive capability of the technique presented here covers a variety of responses of diverse configurations of ships and ocean platforms, as well as estimation of shallow-water bottom effect. The predictions, however, are less accurate in the region of shorter waves and higher ship speeds.
Parametric multi-frequency raman generation in SF<inf>6</inf> using a Bi-Harmonic Pump

Field: Physics and Astronomy (Physical Sciences)

High-order stimulated Raman scattering was used to generate coherent radiation from 1.49 mum to 330 nm. A probe pulse injected after the pump scattered into 15 intense sidebands with a FWHM from 476 nm to 350 nm.
Chemical Studies on “Clover Sickness”

Field: Agricultural and Biological Sciences (Life Sciences)

Journal Article Chemical Studies on "Clover Sickness": Part I. Isolation and Structural Elucidation of Two New Isoflavonoids in Red Clover Get access Saburo Tamura, Saburo Tamura Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-Ku, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Ching-Fun Chang, Ching-Fun Chang Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-Ku, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Akinori Suzuki, Akinori Suzuki Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-Ku, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Sumio Kumai Sumio Kumai National Institute of Animal Industry, Nishinasuno, Tochigi-ken Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 33, Issue 3, 1 March 1969, Pages 391–397, https://doi.org/10.1080/00021369.1969.10859321 Published: 01 March 1969 Article history Received: 16 August 1968 Published: 01 March 1969
[Ectopic hormone production of beta-subunit of human chorionic gonadotropin by cells of signet ring cell carcinoma of the stomach].

Field: Medicine (Health Sciences)

The ectopic hormone production by tumor cells that have a light optical structure of typical non-endocrine cancers has long attracted the attention of investigation all over the world. Specifically, this concerns the phenomenon of the ectopic production of the beta-subunit of human chorionic gonadotropin (beta-hCG) by non-germinogenic tumors, which is, according to R.K. Iles's data, encountered in 20-40% of malignant epithelial tumors. Despite the fact that beta-hCG synthesis is traditionally regarded as the prerogative of germinogenic tumors, the world's literature contains strong evidence for latent beta-hCG gene expression and many cases of clinically evident manifestation of the effects of chorionic gonadotropin. The latter fact, if a clinician and a pathologist are unaware of the behavior of a tumor, may give rise to a diagnostic error and incorrect treatment policy.
Annotated data analysis of three-dimensional optical coherence tomography of the retina for the creation of an intelligent database

Field: Medicine (Health Sciences)

Optical coherence tomography is one of the key diagnostic methods used in ophthalmology and has a high potential for application in an automatic analysis. In this study, we collected, annotated, and analyzed 44 three-dimensional optical coherence tomography images obtained in 39 patients suffering from central serous chorioretinopathy. A semantic annotation of the pathological changes includes three classes: (1) retinal neuroepithelial detachment, (2) retinal pigment epithelium alteration, and (3) a leakage zone. Machine learning methods have been applied to distinguish classes 2 and 3 based on the brightness characteristics of optical coherent tomography images. Intra-group clustering of the class instances showed that the separation of two groups of changes in class 2 can be associated with differences in the volumetric characteristics, whereas the brightness characteristics in class 3 differ significantly depending on the age of the patients, which can be used to predict the course of the disease.
Understanding the mental health and well-being of early adolescents in foster care

Field: Psychology (Social Sciences)

Children in foster care are at high risk of experiencing mental health problems and tackling this issue is a key priority. Previous research suggests that the transition from primary to secondary school can be particularly challenging, as well-being declines and mental health problems increase in early adolescence. However, there is insufficient understanding of variations in the well-being and mental health of this group of children, and particularly the role played by their social interactions, relationships, and psychological attributes. This thesis includes three papers reporting on a programme of empirical research conducted to address this gap in knowledge and better understand the risk and protective factors, particularly in the peer context, for changes in mental health and well-being. The first paper focuses on current provision and reports the findings from a national survey of Virtual Schools that support the education of children in care. The second paper presents the findings of a longitudinal study with children not in care (aged 10-13 years), to test our conceptual model in the general population. This demonstrated that peer factors predict changes in mental health problems and well-being over and above parental and other adult support. The third paper presents findings from a longitudinal study of children in foster care (aged 10-14 years), to test these key pathways in our focus population. This revealed a pattern of differentiated links from peer and adult support to mental health and well-being, and identified self-efficacy as a key longitudinal predictor of change, especially when moderated by peer relationship quality. The thesis demonstrates the importance of supportive relationships with both adults and peers for the mental health and well-being of children in care. This has important implications for future work where social activities and relationship quality with peers should be considered as potential protective factors, especially in school settings.
Data and code for "Logistic and preference bias in participatory science butterfly observations"

Field: Computer Science (Physical Sciences)

This repository contains all code needed to replicate the analyses performed in "Identification ease, wing pattern diversity, and family explain taxonomic bias in butterfly observations" by Goldstein, Stoudt, Lewthwait, Shirey, Mendoza, and Guzman. Components The main code to be executed is contained in the "code" folder and should be run in numeric order (00 through 03) with two helper scripts. All but one of the data inputs can be found in the "data" folder. The iNaturalist data is required but not published within this directory. It may be obtained from GBIF at this link and should be saved into the "data" folder. Note that, at the request of eButterfly, we have removed location information for eButterfly observations of sensitive species in this repository. Please contact eButterfly directly for the uncensored data. Other notes The code in the "01" file takes a long time to run (all of the GAMs for each species). You can skip ahead to "02" to run meta-analysis code on the species-level results, which we provide in "output" as "estimated_indices_fromGAMs.csv".
Toll‐like receptor expression during inflammatory processes in human diseases

Field: Immunology and Microbiology (Life Sciences)

Abstract Multi‐cellular organisms, including humans, have evolved immune systems as defense mechanisms against pathogens. The immune system employs the Toll‐like receptor (TLR) family as its primary defensive mechanism against infections. Their capacity to identify both foreign microbes and endogenous substances renders them crucial for controlling immune responses. This article aims to provide an overview of the structure, functions, properties and signaling mechanisms of TLRs. Additionally, it explores the involvement of TLRs in various disorders and discusses therapeutic strategies targeting TLR signaling pathways. TLRs are widely present in immune and non‐immune cells and are dynamically regulated based on specific stimuli, such as pathogens or damaged host cells. Their activation triggers signaling cascades that lead to the production of type 1 interferons and proinflammatory cytokines. However, excessive TLR activation disrupts immune homeostasis and contributes to inflammatory and autoimmune diseases. Innovative TLR signaling pathway antagonists and inhibitors have been developed to combat these conditions. TLRs are central to the immune system's ability to combat infections and maintain natural defenses. A novel challenge in the treatment of numerous disorders is the preservation of immune homeostasis while targeting TLR signaling.
The Soviet Union

Field: Social Sciences (Social Sciences)

Essay| March 01 1930 The Soviet Union Edgar S. Furniss Edgar S. Furniss Chairman, Department of the Social Sciences, Yale University; Current History Associate Search for other works by this author on: This Site PubMed Google Scholar Current History (1956) 31 (6): 1229–1231. https://doi.org/10.1525/curh.1930.31.6.1229 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Edgar S. Furniss; The Soviet Union. Current History 1 January 1956; 31 (6): 1229–1231. doi: https://doi.org/10.1525/curh.1930.31.6.1229 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCurrent History Search This content is only available via PDF. © 1930 by The Regents of the University of California1930 Article PDF first page preview Close Modal You do not currently have access to this content.
Occurrence Download

Field: Agricultural and Biological Sciences (Life Sciences)

A dataset containing 49278585 species occurrences available in GBIF matching the query: { "and" : [ "Country is France", "Year 1970-2019" ] } The dataset includes 49278585 records from 1655 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0024263-181108115102211/datasets/export for details. Data from some individual datasets included in this download may be licensed under less restrictive terms.
RATE OF AND BIAS TO TECHNICAL CHANGE UNDER A REGIME OF ALMOST HOMOGENEITY OF THE PRODUCTION FUNCTION

Field: Economics, Econometrics and Finance (Social Sciences)

This paper utilizes the concept of almost homogeneity to obtain a generalization of the elasticity of factor substitution. From this, an expression for the bias to technical change is derived that explicitly includes the individual degrees of input homogeneity. It is shown that the relative values of these homogeneity parameters can affect the magnitude and direction of the factor-saving bias to technical change. These parameters also influence the size of the residual or unexplained component of aggregate output growth.
Extraction and atomic absorption spectrophotometric determination of manganese with 4-benzoyl-3-methyl-1-phenyl-5-pyrazolone

Field: Chemistry (Physical Sciences)

The use of the enrichment process by extraction technique prior to the determination by atomic absorption spectrophotometry is very effective to remove interferences and to concentrate the trace element. The procedure was applied to the determination of the trace amount of manganese by the extraction of its complex of 4-benzoyl-3-methyl-1-pheny1-5-pyrazolone(BMPP) into MIBK, and subsequently by the atomic absorption spectrophotometry. The standard analytical procedure is as follows: After neutralizing the sample solution containing less than 4.0 μg of manganese, it was adjusted to pH 8.0 by adding 5 ml of NH4OH-NH4l buffer solution, and then the solution was made up to 40 ml with distilled water. After the manganese was extracted as the Mn-BMPP complex into 10 ml of 0.1% (w/v) BMPP-MIBK solution by shaking them for 5 min, the separated organic phase was centrifuged for 5 min to remove the trace of water in it. Atomic absorption measurements were done for the organic phase thus obtained. This method was applied to determine manganese in carbonated drinks by means of a standard addition procedure.
Film Psychotherapy in the 21st Century

Field: Psychology (Social Sciences)

Psychotherapy is commonly depicted in films. Films, then, help to inform the public about the nature of psychotherapy and psychotherapists. Although much has been written about the portrayal of psychotherapy in films, there has been little empirical investigation of films from the 21st century. The current study provides a systematic investigation of the portrayal of therapists and therapy in films released between 2000 and 2013. Trained volunteers coded films with characters identified as psychotherapists. Data are presented for ratings on 22 films in which therapist characters appeared on screen for at least 15 minutes. Therapists were predominantly Caucasian, male, and between ages 40 and 60 years. Their most common characteristics were generally positive-intelligent, caring, knowledgeable, and compassionate. More than half were portrayed as unethical, and more than one-third as manipulative. Therapists were also commonly shown as touching clients in some way, disclosing client information without permission, and becoming involved in social relationships with clients. In addition, it was often unclear whether clients benefitted from their engagement in therapy. The observed portrayals raise serious concerns about their potential impact on viewers. Viewers may be discouraged from seeking help and may have increased vulnerability to exploitation because of a lack of understanding of what is appropriate and inappropriate therapist behavior.
Life cycle cost analysis of a hybrid photovoltaic-thermal water and air collector: A comparison study based on energy and exergy

Field: Energy (Physical Sciences)

In this present paper, a life cycle cost analysis based on the energy and exergy analysis of a hybrid photovoltaic-thermal (HPV/T) water collector has been carried out for various Indian cities, i.e. Srinagar, Mumbai, Jodhpur, New Delhi and Banglore. The main focus of the study is to see the effect of interest rate, life of HPV/T water collector, subsidy, etc, on cost/kWh. The study reveals that (i) annual thermal and electrical efficiency decreases with an increase in solar radiation and (ii) cost/kWh is higher in the case of exergy than in the case of thermal energy. The results of a HPV/T water and air collector have also been compared. It is observed that the thermal efficiency of a HPV/T water collector is higher than that of a HPV/T air collector by 20%–25%. Similarly, electrical and exergy efficiencies differ by 2%–5%. Further, it is observed that the cost/kWh of a HPV/T water collector is lower than that of a HPV/T air collector for all locations covered in the study. Copyright , Manchester University Press.
A small collection of hepatics from Oregon and California (western North America)

Field: Agricultural and Biological Sciences (Life Sciences)

Identification of small hepatic collection of 112 specimens, collected by M. Ignaotvin California and Oregon, reveals 47 species (46 liverworts, 1 hornwort), including 9 species new to California: Cephaloziella varians, Chilosсyphus rivularis, Lophozia guttulata, Lophozia savicziae, Marchantia alpestris, Plagiochila ovalifolia, Scapania obscura, Solenostoma pseudopyriflorum, and Scapania parvifolia var.grandiretis.Annotated list include comments on ecology and, in some cases, species morphology.The key for Scapania sect.Ciliatae (S. ciliata, S. hirosakiensis, S. americana, S. hollandiae) distributed in North