jimnoneill/paper-to-field-training huggingface dataset:
Effects of a priming dose of alfaxalone on the total anesthetic induction dose for and cardiorespiratory function of sedated healthy cats

Field: Veterinary (Health Sciences)

Abstract OBJECTIVE To investigate the effects of a priming dose of alfaxalone on the total anesthetic induction dose for and cardiorespiratory function of sedated healthy cats. ANIMALS 8 healthy adult cats. PROCEDURES For this crossover study, cats were sedated with dexmedetomidine and methadone administered IM. Cats next received a priming induction dose of alfaxalone (0.25 mg/kg, IV) or saline (0.9% NaCl) solution (0.025 mL/kg, IV) over 60 seconds and then an induction dose of alfaxalone (0.5 mg/kg/min, IV) until orotracheal intubation was achieved. Cardiorespiratory variables were recorded at baseline (immediately prior to priming agent administration), immediately after priming agent administration, after orotracheal intubation, and every 2 minutes until extubation. The total induction dose of alfaxalone was compared between the 2 priming agents. RESULTS Mean ± SD total anesthetic induction dose of alfaxalone was significantly lower when cats received a priming dose of alfaxalone (0.98 ± 0.28 mg/kg), compared with when cats received a priming dose of saline solution (1.41 ± 0.17 mg/kg). Mean arterial blood pressure was significantly higher when alfaxalone was used as the priming dose. No cats became apneic or had a hemoglobin oxygen saturation of < 90%. Expired volume per minute was not significantly different between the 2 priming agents. CONCLUSIONS AND CLINICAL RELEVANCE Administration of a priming dose of alfaxalone to healthy sedated cats reduced the total dose of alfaxalone needed to achieve orotracheal intubation, maintained mean arterial blood pressure, and did not adversely impact the measured respiratory variables.
iDoComp: a compression scheme for assembled genomes

Field: Computer Science (Physical Sciences)

Motivation: With the release of the latest next-generation sequencing (NGS) machine, the HiSeq X by Illumina, the cost of sequencing a Human has dropped to a mere $4000. Thus we are approaching a milestone in the sequencing history, known as the $1000 genome era, where the sequencing of individuals is affordable, opening the doors to effective personalized medicine. Massive generation of genomic data, including assembled genomes, is expected in the following years. There is crucial need for compression of genomes guaranteed of performing well simultaneously on different species, from simple bacteria to humans, which will ease their transmission, dissemination and analysis. Further, most of the new genomes to be compressed will correspond to individuals of a species from which a reference already exists on the database. Thus, it is natural to propose compression schemes that assume and exploit the availability of such references. Results: We propose iDoComp, a compressor of assembled genomes presented in FASTA format that compresses an individual genome using a reference genome for both the compression and the decompression. In terms of compression efficiency, iDoComp outperforms previously proposed algorithms in most of the studied cases, with comparable or better running time. For example, we observe compression gains of up to 60% in several cases, including H.sapiens data, when comparing with the best compression performance among the previously proposed algorithms. Availability: iDoComp is written in C and can be downloaded from: http://www.stanford.edu/~iochoa/iDoComp.html (We also provide a full explanation on how to run the program and an example with all the necessary files to run it.). Contact: iochoa@stanford.edu Supplementary information: Supplementary Data are available at Bioinformatics online.
The effect of noise on adaptive envelope-constrained filters

Field: Computer Science (Physical Sciences)

The performance of the envelope-constrained filters designed by the newly developed adaptive algorithms may deteriorate when the input signal is contaminated by noise. The average window with a growing window size, and the exponentially weighted average window are presented. It is shown that the noise-induced bias in the augmented cost function will be reduced because applying such an averaging scheme helps increase values of the signal-to-noise ratio at the filter input channel. With this, the noise effect on the adaptive envelope-constrained filters can be depressed. Simulation results are given to illustrate the improved performance of the adaptive envelope-constrained filters designed in conjunction with the average window.
Y Chromosomal STR Polymorphism in Northern Chinese Populations

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Y chromosomal STRs show sufficient variability among individduals in a population and a high degree of geographical differentiation, such that their polymorphic character makes them especially suited for population genetic studies. To investígate the polymorphism of a set of 17 Y-STR loci in northern China, we genotyped the 17 Y chromosomal STR loci in a population sample of 377 unrelated males from eight ethnic populations in northern China. We calculated the haplotype frequencies, Rst value and carried out the analysis of molecular variance (AMOVA). We then drew the multidimensional scaling analysis (MDS) plot and phylogenetic tree based on the Rst value. All populations showed a high level of haplotype diversity, with low inter-population variance as measured by an analysis of molecular variance. However, the genetic distances were significant when the eight populations were compared to other populations. By MDS and the phylogenetic tree, we found that the eight populations had a close relationship and Xibo had a northeast origination.
PENGGESERAN REAKSI KESETIMBANGAN HIDROLISIS MINYAK DENGAN PENGAMBILAN GLISEROL UNTUK MEMPEROLEH ASAM LEMAK JENUH DARI MINYAK BIJI KARET

Field: Chemical Engineering (Physical Sciences)

<p>Abstract: Indonesia is one of the largest rubber producers in the world. Rubber seed is obtained<br />as agricultural waste. This is a potential feedstock for biodiesel because of its high proportion of<br />oil. The oil is hydrolyzed to produce saturated and unsaturated fatty acids. Unsaturated fatty acids<br />such as oleic, linoleic and linolenic acids are good for health. Besides, saturated fatty acids are<br />suitable for high-quality biodiesel by esterification. Batch process of rubber seed hydrolysis was<br />conducted on this research to produce fatty acids and glycerine. In case of its reversible reaction,<br />continuously separation of product or increasing reactant-concentration was needed to achieve<br />equilibrium conversion. In this batch process, continuously separation of glycerine was done by<br />settling it stage by stage (multi stages). The objection of this research was to find optimum<br />condition on multi stages hydrolysis to produce fatty acids. It was processed on hydrochloric-acid<br />catalyzed, fifty-fifty ratio of oil and water, and reacted in 70<br />C. In each stage of hydrolysis,<br />glycerine and water was separated from reaction mixture by settling on 24 hours. The fatty acids<br />were re-hydrolyzed with fresh water like the stage before. The process was stopped while it<br />reached maximum conversion (almost completely). Based on this research, we concluded that<br />for the shorter time of each stage on hydrolysis-process gives higher conversion of oil to fatty<br />acids.<br />o<br />Keywords: fatty acids, multi stages hydrolysis, Rubber Seed Oil, reaction equilibrium.</p>
Factors associated with Brain Function in Patients with Eating Disorders

Field: Medicine (Health Sciences)

Purpose: The purpose of this study was to investigate the factors associated with brain function in patients with eating disorders.Methods: Patients(N=171) who visited 'M' clinic for eating disorders participated. Data were collected from June 2022 to September 2022 using self-reported questionnaires.Results: Problems with brain function were observed in the deep limbic system in 84.8%, basal ganglia in 78.9%, the anterior cingulate in 74.3%, the prefrontal lobe in 55.6%, and the temporal lobe in 34.5%. Additionally, 55.6% of the participants had more than moderate anxiety, and 32.2% were suspected of having obsessive-compulsive disorder. Anxiety, obsessive-compulsion, and eating psychopathology(ineffectiveness, impulse regulation, social insecurity, body dissatisfaction, perfectionism, and bulimia) were significantly associated factors of brain function.Conclusion: It was found that problems of brain function can be identified in a more convenient way by evaluating brain function through the Amen Brain System Checklist (ABSC), a self-reporting test tool, instead of brain imaging. Through brain function evaluation by the ABSC at the initial interview, more suitable interventions can be selected for patients. In future studies, it is necessary to evaluate the effect of practical interventions according to changes in brain function of patients with eating disorders.
Preparation and in vitro-in vivo Correlation in Dogs of Metoprolol Succinate Sustained-released Tablets

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The formulation of metoprolol succinate sustained-released tablets was optimized using orthogonaldesign. The in vitro dissolution of the preparation and its concentration in dog plasma was determined by UV and HPLC,respectively. The results showed that the drug dissolution coincided with Higuchi equation and the release mechanism forthe preparation was a conjoint effect of diffusion and corrosion. The correlation coefficient of in vitro dissolution and invivo absorption in dogs was 0.9873.
Performance and Noise Analysis of VCSEL ROF Using Spherical-ended Multimode Fiber Coupling

Field: Engineering (Physical Sciences)

A low cost radio-over-fiber (ROF) transmitter has been built based on extremely low cost 850 nm vertical-cavity surface-emitting laser (VCSEL) diode using spherical-ended multimode fiber (MMF) coupling technique. This technique has been shown to deliver excellent light launching characteristics for VCSEL lasers in short haul ROF applications. Transmission distance of more than 600 m has been demonstrated experimentally with consistent performance highly desired for transmitting WLAN RF signals in both 2.45 and 5.25 GHz in a directly modulated MMF VCSEL short haul ROF link. Various coupling methods and the bonding process of mating the VCSEL to MM fiber have been investigated to optimize the optical power coupling for cost reduction and low complexity. The results show that the transmitter coupled by spherical-ended MMF provides 30% more optical coupling efficiency and enhanced noise figure performance than the lens-less flat cleaved alternative
The research on peripheral blood expression and immune action of TLR2 in patients' with ulcerative colitis

Field: Medicine (Health Sciences)

Objective To explore primarily the possible role of Toll-like receptor 2(TLR2) in the inflammatory injury of ulcerative colitis(UC) through detecting the expression of TLR2 and the peripheral blood concentration of monocyte chemoattractant protein-1(MCP-1) and TNF-α in patients' with UC. Methods The RT-qPCR and ELISA were respectively used to measure the expression of TLR2 mRNA in the peripheral blood mononuclear cells and the concentration of MCP-1,TNF-α in the serum,and healthy group were set as control group. Results The expression of TLR2 and the concentration of MCP-1,TNF-α in UC group were significantly higher than those in healthy group(P 0. 01). Conclusion The expression of TLR2 mRNA in the peripheral blood mononuclear cells from UC are elevated,which may play a critical role in the mechanism of inflammatory bowel injury through starting secretion of the downstream cytokines.
Phenotypic and molecular characterization of fluoroquinolone resistant Pseudomonas aeruginosa isolates in Palestine

Field: Immunology and Microbiology (Life Sciences)

Abstract Fluoroquinolones are important antimicrobial agents for the treatment of Pseudomonas infections. A total of 11 isolates of P. aeruginosa were collected from different clinical samples from different medical centers in the North West Bank-Palestine during 2017. In this study, resistance to fluoroquinolones and secretions of β-lactamases were detected by phenotypic methods, while presence of β-lactamase gene sequences and other virulence factors were detected by PCR technique. PCR product for gyrA, parC and parE genes were sequenced for further analyses. The phylogenetic analyses, population diversity indices and haplotypes determination were conducted using computer programs MEGA version 6, DnaSP 5.1001 and median-joining algorithm in the program Network 5, respectively. Results of this study showed that the MIC for ciprofloxacin and norfloxacin had a range of 32-256 µg/ml. In addition, all isolates carried either exoT or exoT and exoY genes, different β-lactamase genes and 82% of these isolates harbored class 1 integrons. Analyses of the gyrA, parC and parE sequences were found to be polymorphic, had high haplotype diversity (0.945-0.982), low nucleotide diversity (0.01225-0.02001) and number of haplotypes were 9 for each gyrA and parE genes and 10 haplotypes for parC gene. The founder haplotypes being Hap-1 (18%), Hap-2 (27.3%) and Hap-6 (9.1%) for gyrA, parC and parE genes, respectively. Two of ParE haplotypes were detected as indel haplotypes. The Median-joining- (MJ) networks constructed from haplotypes of these genes showed a star-like expansion. The neutrality tests (Tajima’s D test and Fu’s Fs test) for these genes showed negative values. Palestinian fluoroquinolone resistant P. aeruginosa strains showed high MIC level for fluoroquinolones, β-lactamase producers, carried type III secretion exotoxin-encoding genes, most of them had integrase I gene and had high level of mutations in QRDR regions in gyrA, parC and parE genes. All these factors may play an important role in the invasiveness of these strains and make them difficult to treat. Isolation of these strains from different medical centers, indicate the need for a strict application of infection control measures in Medical centers in the North West Bank-Palestine that aim to reduce expense and damage caused by P. aeruginosa infections. Molecular analyses showed that Palestinian fluoroquinolone resistant P. aeruginosa haplotypes are not genetically differentiated; however, more mutations may exist in these strains.
INFLUENCE OF THERMAL PROCESSING ON THE NUTRITIONAL COMPOSITION, AMINO ACID PROFILE AND SENSORIAL CHARACTERISTICS OF BISCUITS PRODUCED FROM WHEAT-DEFATTED MELON SEED FLOUR BLENDS

Field: Agricultural and Biological Sciences (Life Sciences)

The study was conducted to investigate the influence of thermal processing on the nutritional composition, amino acid profile and sensorial characteristic of biscuits produced from wheat flour-defatted melon flour blends from toasted and raw melon seeds.The melon seeds was toasted at 160 0 C for 20mins and the other portion left untreated.The treated and untreated melon seed was defatted using n-Hexane and grinded into flour.The flour from the defatted roasted and raw melon seed flour was incorporated with wheat flour at 4 percentage ratio (100:0, 95:5, 90:10, 80:20, 70:30) respectively.Nine (9) samples of biscuit was formulated with other ingredients to produce biscuits according to the standard method and subjected to statistical evaluation in complete randomized design using statistical Product for Social Services version 21.The means were separated using Duncan Multiple test range at (p<0.05).The inclusion of the defatted melon flour from the untreated (raw) and toasted melon significantly increased (p<0.05) the moisture (1.78-3.87%), protein (13.47 to 21.05 %), ash (2.04 to 2.72 %), fat (9.34-12.73%)and reduced (74.92-56.86%) carbohydrate content of the biscuits.The amino acid profile of the biscuits showed significant (p<0.05)difference.The amino acid values varied significantly (p<0.05) and showed increase with increase in the substitution of the defatted melon flour.The amino acid ranged from leucine (7.48 to 9.18 g/100 g), lysine (4.78-9.18g/100g), Histidine (1.89-2.38 g/100g), Arginine (3.12-5.02g/100g) and 10.48-12.80g/100g in glutamic acid respectively.The physical analysis showed significant (p < 0.05) difference among the biscuit samples.The study showed that substitution of wheat flour with defatted raw and toasted defatted melon flour at a ratio of 95:5 and 90:10 yielded the most acceptable biscuits in all the sensory attributes assessed.This implies that biscuits produced from this composite blend contain sufficient amounts of protein, fat, fiber and carbohydrate.Hence, they can serve as relief for malnutrition.
Survey of verification communication protocol security using computational models

Field: Computer Science (Physical Sciences)

With the rapid growth of technologies like the Internet of Things (IoT) and social media, securing communication channels against unauthorized access has become a critical priority. Protecting privacy and ensuring secure interactions requires protocols that not only encrypt data during transmission but also verify the identities of all parties involved. This paper examines widely-used computational models that validate the security of such protocols. It provides an overview of these models, their types, and their roles in analyzing and achieving mutual authentication and secure key exchange. By understanding these frameworks, we can better assess how communication protocols resist attacks and maintain confidentiality in dynamic environments.
Equivalence between preamplified direct detection and heterodyne receivers

Field: Physics and Astronomy (Physical Sciences)

The interrelationship of heterodyne receivers and preamplified direct-detection receivers is explained. The authors compare the performances of the two lightwave receiver schemes, taking into account all of the essential functional blocks needed in a real receiver. This includes analysis of the laser phase noise, the limiting noise processes, the optical and electrical carrier wave filters, the nonlinear demodulation functions, and the baseband filters. Even with these realistic effects included, the two receivers have mathematically equivalent performance under certain conditions, which are rigorously identified. It is shown that this is a general result which is independent of the modulation format used. The established equivalence suggests that the analytical and practical design criteria used for one scheme can also be used for the other.< >
Heterogeneity ofosteogenesis imperfecta typeI

Field: Medicine (Health Sciences)

SUMMARY Wehavestudied 166patientsfrom71 familieswithSillencetypeI osteogenesisimperfecta(dominant inheritance andblue sclerae). Weconfirm earlier findings that there are two subgroups,those with and those without dentinogenesis imperfecta; each family can be allocated to one or othergroup. Ourconfidencethatthetwogroupsrepresent distinct disorders is increasedbyfindingthat the patients with dentinogenesis imperfecta differ not only in their dental characteristics but also in other clinical features. Theyhave a more severe disease with a greater fracture rate and a greaterlikelihoodofgrowthimpairment. It has long been recognised that substantial varia-tions canbefoundamongpatients withosteogenesisimperfecta (01). Patients differ not only in thenatural history ofthecondition, butalso in featuressuch as growth impairment, skull shape, scleral colour, dental abnormality, and joint hyperextens-ibility. Radiologically the bones maybe apparentlynormal or grossly abnormal. Genetic studies haveshown that both dominant and recessive variantsexist.Consideration ofall these forms ofvariation ledSillenceandhiscolleagues1 toproposeaclassificationin whichthereweretwodominantvarieties andtworecessivevarieties of
<title>Laboratory calibration of the EUV spectrometer for the Space Solar Patrol Mission</title>

Field: Physics and Astronomy (Physical Sciences)

The description of the testing for EUV-spectrometer of Space Patrol of the soft X-ray and extreme ultraviolet radiation of Sun is presented. The wavelength calibration was made in vacuum chamber with a window from MgF2. It allows to get spectra in three channels at wavelengths above 1 13 nm. Particularly attention is paid to discussion of observed noises. Analysis of sources of these noises is presented and method of their decreasing at measurements of spectra of Solar ionizing radiation is shortly discussed.
Of Globalatinology

Field: Arts and Humanities (Social Sciences)

Have we ever been religious? It may seem strange to open an essay on Derrida with a Latourean question. Yet, with regard to religion, what Derrida demonstrates is quite unavoidably this: we have long been, and are still being, Christianized. Whatever else we may have been, perhaps still are, constitutes but the space or espacement offered or relinquished, however reluctantly or even grudgingly (though more often than not quite willingly) to Christianization. This is a space that goes beyond whatever is meant by the word or the concept of ‘religion’, under whatever definition. And though Derrida still refers to it, at times, in terms that have themselves become, for the most part, religious markers (Judaism, Islam, etc.), he leaves no doubt that such name calling is part of the Christianization he otherwise documents. This essay attempts to show that the question (let us call it Derrida's ‘Christian question’) is therefore: what is Christianity?
Avoiding Another Crisis in the Euro Area: Public and Private Imbalances and National Policy Responses

Field: Economics, Econometrics and Finance (Social Sciences)

Early critics of the euro’s design pointed to the disruptive potential — both political and economic — of country-specific shocks in a monetary union that is a far cry from an optimal currency area. The euro crisis has confirmed the risks associated with a ‘one-size-fits-all’ monetary policy, decentralized financial supervision, and inadequate fiscal backstops. This article examines how the active use of national fiscal policies and macroprudential policies can mitigate these risks. Cross-border coordination of macroprudential policies is essential to ensure their effectiveness. In addition, area-wide reforms are necessary including a more complete banking union with a well-funded common backstop.
A novel method for automatic standardization of digital electrocardiographs

Field: Health Professions (Health Sciences)

It is crucial to assure the quality of ECG recordings to support correct clinical interpretation. This research aimed at developing an automated standardization method to gauge digital electrocardiography (EC) devices. The proposed microprocessed gauge equipment (MGE) is divided into digital and analogic circuits, and embedded software to control them. Conditioned reference signals (CRS) from Physionet Bank were embedded in the MGE to simulate cardiac activity. The outputs from the MGE (or EC) are then compared with the CRS. All circuits of the MGE are gauged at the self-check mode. CRS are sent to the EC when set at the EC check mode. A commercial EC equipment was used in the MGE validation (IEC60601-2-51:2005), assessed with the statistical R 2 correlation analysis and Kolmogorov-Smirnov (KS). At the MGE self-test, temperature and humidity were changed (R 2 ≥0.99 as designed). The KS test (P<;0.01) resulted in D=0.012 for amplitude accuracy, 0.0028 for timing accuracy and 0.021 for signal stability against noise influence. All KS values were lower than their respective critical values according to the default standard (5%). Finally, visual inspection between EC signals and CRS on printed graph paper at a standard scale certifies the EC reliability.
LHD NB2arm #936403.365

Field: Physics and Astronomy (Physical Sciences)

The neutral beam (NB) shine-through profile is routinely monitored on the Large Helical Device (LHD) both to calibrate the port-through power of the NB and to evaluate the NB-deposition power to LHD plasmas. The profile is measured with a calorimeter (CM) array on an armor plate of the NB counter wall inside the LHD vacuum vessel.