jimnoneill/paper-to-field-training huggingface dataset:
Circular RNA expression in isoproterenol hydrochloride-induced cardiac hypertrophy

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Circular RNA (circRNA) is a novel class of noncoding RNAs, and the roles of circRNAs in the development of cardiac hypertrophy remain to be explored. Here, we investigate the potential roles of circRNAs in cardiac hypertrophy. By circRNA sequencing in left ventricular specimens collected from 8-week-old mice with isoproterenol hydrochloride-induced cardiac hypertrophy, we found 401 out of 3323 total circRNAs were dysregulated in the hypertrophic hearts compared with the controls. Of these, 303 circRNAs were upregulated and 98 were downregulated. Moreover, the GO and KEGG analyses revealed that the majority of parental gene of differentially expressed circRNAs were not only related to biological process such as metabolic process and response to stimulus, but also related to pathway such as circulatory system and cardiovascular diseases. On the other hand, total 1974 miRNAs were predicted to binding to these differentially expressed circRNAs, and the possible target mRNAs of those miRNAs were also predicted and analyzed in terms of functional annotation. Finally, we identified that ANF and miR-23a are downstream targets of circRNA wwp1, suggesting that circRNA wwp1 exerts inhibitory roles of cardiac hypertrophy via down-regulation of ANF and miR-23a, which underlying the potential mechanisms whereby circRNA regulates cardiac hypertrophy.
"That building with the palm trees": Wellington Central Library

Field: Arts and Humanities (Social Sciences)

Athfield Architects' postmodern Wellington Central Library (1991) represented the firm's entry into public architecture. Part of the Civic Square development, and Aotearoa New Zealand's largest construction project at the time, it was a propitious turn away from the corporate work that went from boom to bust in the wake of the 1987 share market crash. The library was a critical and popular success, winning three major awards and becoming known as "Wellington's living room." Fast forward to 19 March 2019, and it was closed with a few hours warning due to seismic concerns. Fears for its future prompted a public nomination for the New Zealand Heritage List/Rārangi Kōrero. This paper will explore the building's history, design and heritage values.
Development and Validation of a Competency-Based Learning Package in Plumbing NC II

Field: Health Professions (Health Sciences)

The study aimed to develop a competency-based learning package in Plumbing NC II. Specifically, it determined the validity of the learning package in terms of objectives, activities, instructional characteristics, evaluative characteristics, and physical make-up. The descriptive-development methodology was used in the study. In addition, content validation was conducted by three experts in Outcome-Based Education. Results showed that the material generally meets the standards of a Competency-Based Learning Material. It has a very high level of validity particularly along with its objectives, activities, instructional characteristics, evaluative characteristics and physical make-up. The developed competency-based learning package is strongly recommended for use in training students for the Plumbing NC II assessment. The use of the learning package may reduce the workload of the trainers while students are engaged to self-directed learning and to ensure to cover all the competencies that shall be developed by the students.
Various phenomena on a water vortex in a cylindrical tank over a rotating bottom

Field: Engineering (Physical Sciences)

Flows in a cylindrical tank over a rotating bottom are investigated by laboratory experiments. Despite the axisymmetry of the experimental setup, various anisotropic phenomena are observed. The slow rotation of the bottom disk induces a circular flow according to the axisymmetric environment, but polygonal vortices form under faster rotation. Between these two vortex flow states, the flow undergoes a transition with clear hysteresis during which the elliptical shape assumed under faster rotation is retained when the rotation is subsequently slowed to rates that previously supported axisymmetric flow. Sloshing is also observed; here, a calm circular flow state alternates with an oscillation of the water surface along the sidewall of the container. A phase diagram showing the phenomena observed under different combinations of the initial water depth at rest and the rotation rate of the bottom disk is developed following thorough experimental testing over a wide range of parameter values. The features of the dependences of the range for each phenomenon to occur on these parameters are also elucidated.
Peel Oil Components of Clementine Mandarin on Different Rootstocks

Field: Agricultural and Biological Sciences (Life Sciences)

The aim of this research is to identify rootstock that can synthesize the maximum level of oxygenated compounds. Peel oil was extracted using mechanical presses and eluted using n-hexane. Finally compounds were analyzed using GC-FID and GC-MS. Twenty-four, Twenty-seven and twenty-six compounds were identified in Trifoliate orange, Orlando tangelo and Murcott rootstocks, respectively Limonene (% 92.55 to 93.09) and myrcene (%1.59 to %1.70) were the main compounds. Among the three rootstocks studied, Orlando tangelo demonstrated the maximum level of oxygenated compounds. As a result of our research, we can express that the rootstocks can affect the amount of oxygenated compounds.
Scale of Commitment of UK Business to Property in the UK

Field: Business, Management and Accounting (Social Sciences)

The commitment to corporate real estate (CRE) is important at several levels. At a country level it is an important factor in the assessment of the scale that corporate real estate has in contributing to the country directly and indirectly. It is also important to understand the relative balance between the landlord and the occupier equation, as corporate real estate has been and still remains the Cinderella of the real estate world, with an under representation in the press, in the professions that service it and within academia. For the corporate themselves CRE tends to be treated as a cost aspect to the business and not something that adds value to the business, both in terms of the bottom line and shareholder value.The work on assessing the actual levels of commitment has been limited and this work is intended to be part of a larger project. This initial piece is a snap shot of 12 months of accounts for the FTSE350, that is the top 350 quoted companies listed in the UK, but with a longitudinal time line for certain sectors. Ultimately the aim is to run the analysis across all sectors of the FTSE350 to ascertain how the profile of property within business has changed over time and in particular through the recession.
Race, prior offending, and juvenile court outcomes

Field: Social Sciences (Social Sciences)

Both theory and research in the study of race in the juvenile justice system have attempted to identify the contexts in which race matters. The objectives of the present research are to examine the roles that race and the history of prior offending, individually and in combination, have on juvenile justice outcomes at detention, intake, adjudication and judicial disposition. An interpretation of the focal concerns/loosely coupled perspective is used as a backdrop to analyze data from a Midwestern county juvenile court to address these objectives. While race and the history of prior offending individually explained case outcomes, the interrelationship between the two with court decision-making, for the most part, was not found to exist. The overall results suggest that prior offending may not be racialized as hypothesized in this juvenile court but being black by itself results in unjust treatment.
Modeling Dual-Task Performance: Identifying Key Predictors Using Artificial Neural Networks

Field: Psychology (Social Sciences)

Dual-task paradigms that combine cognitive and motor tasks offer a valuable lens for detecting subtle impairments in cognitive and physical functioning, especially in older adults. This study used artificial neural network (ANN) modeling to predict clinical, cognitive, and psychosocial outcomes from integrated gait, speech-linguistic, demographic, physiological, and psychological data collected during single- and dual-task conditions. Forty healthy adults (ages 20–84) completed physical, cognitive, and psychosocial assessments and a dual-task walking task involving cell phone use. ANN models were optimized using hyperparameter tuning and k-fold cross-validation to predict outcomes such as the Montreal Cognitive Assessment (MOCA), Trail Making Tests (TMT A and B), Activities-Specific Balance Confidence (ABC) Scale, Geriatric Depression Scale (GDS), and measures of memory, affect, and social support. The models achieved high accuracy for MOCA (100%), ABC (80%), memory function (80%), and social support satisfaction (75%). Feature importance analyses revealed key predictors such as speech-linguistic markers and sensory impairments. First-person plural pronoun used and authenticity of internal thoughts during dual-task emerged as strong predictors of MOCA and memory. Models were less accurate for complex executive tasks like TMT A and B. These findings support the potential of ANN models for the early detection of cognitive and psychosocial changes.
Restricted total least squares solutions for hyperspectral imagery

Field: Computer Science (Physical Sciences)

Hyperspectral image processing is a pixel-by-pixel approach to the detection and localization of features by spectral analysis techniques. Usually, partial knowledge about the feature, noise, and clutter spectra are provided, and the problem is to 'unmix' each pixel, or to estimate the relative concentrations of the reference spectra on a per pixel basis. A popular method of linear spectral unmixing for hyperspectral imagery is linear least squares. Linear least square approaches are appropriate when observational errors predominate and are inappropriate when significant modeling errors are present. The least square approach has some disadvantages, especially in cases with few, poorly known references or significant reference variation throughout an image. In this article, the restricted total least squares (RTLS) approach is presented and evaluated on experimental data. Although the proposed RTLS require more calculations than linear least squares, its relative error performance is much better.
Ab Initio Calculation of Lattice Thermal Conductivity

Field: Physics and Astronomy (Physical Sciences)

An ab-initio-based theoretical approach was presented to accurately describe phonon thermal transport.Harmonic and anharmonic interatomic force constants (IFCs) are the only inputs required for exact solution of phonon Boltzmann equation, thus the crucial elements required to calculate thermal conductivity.In this work, first principles using density functional perturbation theory was employed to calculate the harmonic IFCs.The third order anharmonic IFCs are determined by 2n+1 theorem.The calculated lattice thermal conductivities for Si and Ge, both isotopically enriched and naturally occurring, are in excellent agreement with experimental data.
Analysis of the LBM Experiments at LOTUS

Field: Physics and Astronomy (Physical Sciences)

The irradiation of the LBM at the LOTUS facility is analysed using a three-dimensional model with the Monte Carlo code MCNP and a two-dimensional r-z model with the deterministic transport code TRISM. A sensitivity and uncertainty analysis based on the 2-D model was performed using the sensitivity code SENSIT-2D. The JEF-1/EFF and ENDF/B-V libraries were used for transport calculations. The COVFILS-2 covariance and uncertainty library based on ENDF/B-V was used for sensitivity and uncertainty analyses.
A good agreement between JEF-1/EFF and ENDF/B-V libraries was achieved. The uncertainty in the calculated tritium breeding ratio by the indirect term of the overall cross-section uncertainties varies in the dependence on the position in the LBM from 1.4% (front) to 35.8% (back).
Antibodies to endogenous and recombinant erythropoietin

Field: Medicine (Health Sciences)

Owing to the very few cases of anti-erythropoietin (EPO) antibodies arising in patients treated with recombinant human EPO (rHuEPO) before 1998, it was generally believed that EPO is weakly immunogenic. Several recent reports, however, suggest that this theory may be wrong. Indeed, low amounts of rHuEPO are immunogenic in animals such as the mouse, rat, rabbit, or horse, despite the high degree of sequence identity of the mammalian EPO molecules. Interestingly, in most cases injection of rHuEPO to these animals not only leads to production of antibodies that recognize the injected rHuEPO but also cross react with the endogenous EPO molecule and neutralize it, leading to pronounced anemia in rHuEPO-treated animals [1, and our own unpublished data]. A hybrid molecule linking recombinant human granulocytemacrophage colony-stimulating factor (rHuGM-CSF) and EPO has been administrated to rhesus monkeys. This treatment induced a neutralizing immune response to EPO, whereas no antibodies against GM-CSF were detected. Again, the anti-EPO antibodies cross reacted with monkey EPO and induced a pronounced anemia [2]. Thus, the low incidence of neutralizing antiEPO antibodies among rHuEPO-treated patients is most likely due to the good quality of the available rHuEPO preparations rather than to a low antigenic property of the molecule itself. rHuEPO appears to differ from endogenous human EPO only at the level of glycosylation. This high similarity explains why rHuEPO treatment exhibits a high degree of both efficiency and safety. During the last four years, however, a large number of cases of pure red cell aplasia due to neutralizing anti-EPO antibodies have been reported in patients treated with rHuEPO for anemia associated with renal failure of various etiologies [3]. In this review, we address several questions:
<title>Bubble formation by retinal laser effects produced by submicrosecond (200 ns) Nd:YAG (532 nm) laser pulses: macroscopic observations</title>

Field: Medicine (Health Sciences)

Retinal photocoagulation was observed with repetitive short laser pulses of a Nd:YAG laser. The number of pulses applied was 10 and 500. Threshold curves for angiographic and ophthalmoscopical visibility as well as for bleeding were established. No macroscopic disruptive effects were observed, however macroscopic visible bubble formation occurred regularly at energy levels 2 times above ophthalmoscopical visibility. Bubble formation as primary interaction mechanism due to local overheating of single melanin granules is postulated.
Effects of Particle Segregation and Grain Pressure on Ventilation Airflow and Temperature–Humidity Distribution in Maize Pilot Silo

Field: Engineering (Physical Sciences)

The distribution of grain particles within a silo influences heat and moisture transfer during stored grain ventilation, leading to grain quality losses. A study on porosity distribution analysis and ventilation tests was conducted in a pilot silo with a height of 3 m, a diameter of 1.5 m, and a conical dome height of 0.85 m. The E-B constitutive model was incorporated into the secondary development of FLAC3D 5.0 to analyze the vertical pressure distribution in the grain bulk. An anisotropic porosity distribution model for the maize bulk was developed, accounting for both vertical pressure and segregation mechanisms. The differences in airflow and heat transfer during ventilation between isotropic and anisotropic porosity distributions were quantified. A nonlinear model was innovatively proposed to predict the temperature front curve (TFC) during ventilation as affected by porosity variation. The results indicate that friction between the maize kernel and the silo wall led to vertical pressure at the center of the bottom that was 10.7% higher than that near the wall. The average surface porosity of the maize bulk was 2.8% higher than at the bottom. This led to a minimum porosity of 0.409 at the center of the silo bottom, due to the combined effect of impact during the loading process and vertical pressure. The numerical simulation demonstrated excellent consistency with the experimental data. At a supply vent air velocity of 0.126 m/s, an increase in the maize bulk height from 0.725 m to 2.9 m resulted in reductions in airflow rate and average relative humidity of 20.3% and 9.67%. The airflow velocity near the wall was 13.4% higher than that in the center, leading to a faster cooling rate in the peripheral region compared to the center of the maize bulk. The airflow velocity based on the isotropic porosity model was higher at the center than that predicted by the anisotropic model, whereas the opposite trend was observed near the wall. The temperature front during ventilation based on the anisotropic porosity model exhibited a concave curve. A nonlinear model was developed to predict this temperature front, showing strong agreement with computational data.
HUMAN CAPITAL AND SOCIAL CAPITAL IN ENTREPRENEURS AND MANAGERS OF SMALL AND MEDIUM ENTERPRISES

Field: Business, Management and Accounting (Social Sciences)

This paper uses factor analysis methods to identify structures associated with human and social capital in a small country with an open-economy, based on a survey of small- and medium-sized companies across different sectors. The purpose of this research is to investigate the influences of entrepreneurial and managerial behaviours on the relationship between human capital and social capital. The results indicate that the principal factor is highly correlated to the variables of experience, professional proficiency and cognitive ability, which are predominant characteristics of the entrepreneur, as well as status variables such as interlinking, family support, personal relations and social relations. The study also suggests that links between human capital and social capital are more salient in manufacturing and construction companies than in the wholesale trade, retail trade and services sectors.
Existence of positive solutions for a nonlinear fractional differential equation

Field: Mathematics (Physical Sciences)

Using the Schauder fixed point theorem, we prove an existence of positive solutions for the fractional differential problem in the half line $mathbb{R}^+=(0,infty)$: $$ D^{alpha}u=f(x,u),quad lim_{x o 0^+}u(x)=0, $$ where $alpha in (1,2]$ and $f$ is a Borel measurable function in $mathbb{R}^+imes mathbb{R}^+$ satisfying some appropriate conditions.
Ophthalmic Magnetic Resonance Imaging: Where Are We (Heading To)?

Field: Medicine (Health Sciences)

Magnetic resonance imaging of the eye and orbit (MReye) is a cross-domain research field, combining (bio)physics, (bio)engineering, physiology, data sciences and ophthalmology. A growing number of reports document technical innovations of MReye and promote their application in preclinical research and clinical science. Realizing the progress and promises, this review outlines current trends in MReye. Examples of MReye strategies and their clinical relevance are demonstrated. Frontier applications in ocular oncology, refractive surgery, ocular muscle disorders and orbital inflammation are presented and their implications for explorations into ophthalmic diseases are provided. Substantial progress in anatomically detailed, high-spatial resolution MReye of the eye, orbit and optic nerve is demonstrated. Recent developments in MReye of ocular tumors are explored, and its value for personalized eye models derived from machine learning in the treatment planning of uveal melanoma and evaluation of retinoblastoma is highlighted. The potential of MReye for monitoring drug distribution and for improving treatment management and the assessment of individual responses is discussed. To open a window into the eye and into (patho)physiological processes that in the past have been largely inaccessible, advances in MReye at ultrahigh magnetic field strengths are discussed. A concluding section ventures a glance beyond the horizon and explores future directions of MReye across multiple scales, including in vivo electrolyte mapping of sodium and other nuclei. This review underscores the need for the (bio)medical imaging and ophthalmic communities to expand efforts to find solutions to the remaining unsolved problems and technical obstacles of MReye, with the objective to transfer methodological advancements driven by MR physics into genuine clinical value.
New England Dental Society.

Field: Dentistry (Health Sciences)

Editors: Aug. 1859-July 1865, J. D. White, J. H. McQuillen, G. J. Ziegler.--Aug. 1865-Dec. 1871, J. H. McQuillen, G. J. Ziegler.--Jan. 1872-May 1891, J. W. White.--July 1891-Apr. 1930, E. C. Kirk (with L. P. Anthony, Dec. 1917-Apr. 1930).--May 1930-Dec. 1936, L. P. Anthony.
Fiction and Incarnation: Rhetoric, Theology, and Literature in the Middle Ages; The Performance of Self: Ritual, Clothing, and Identity During the Hundred Years War

Field: Arts and Humanities (Social Sciences)

Book Review| June 01 2004 Fiction and Incarnation: Rhetoric, Theology, and Literature in the Middle Ages; The Performance of Self: Ritual, Clothing, and Identity During the Hundred Years War Fiction and Incarnation: Rhetoric, Theology, and Literature in the Middle Ages. By Alexandre Leupin. Translated by David Laatsch. Minneapolis: University of Minnesota Press, 2003. xxiv, 256 p.The Performance of Self: Ritual, Clothing, and Identity During the Hundred Years War. By Susan Crane. Philadelphia: University of Pennsylvania Press, 2002. 269 p. Seth Lerer Seth Lerer Search for other works by this author on: This Site Google Comparative Literature (2004) 56 (3): 262–266. https://doi.org/10.1215/-56-3-262 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Permissions Cite Icon Cite Search Site Citation Seth Lerer; Fiction and Incarnation: Rhetoric, Theology, and Literature in the Middle Ages; The Performance of Self: Ritual, Clothing, and Identity During the Hundred Years War. Comparative Literature 1 June 2004; 56 (3): 262–266. doi: https://doi.org/10.1215/-56-3-262 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsComparative Literature Search Advanced Search The text of this article is only available as a PDF. University of Oregon2004 Article PDF first page preview Close Modal You do not currently have access to this content.
5. Special duty problems: public bodies

Field: Social Sciences (Social Sciences)

Public bodies have extensive powers to act for the public benefit but often have limited resources. Difficult decisions have to be made, and if those decisions are wholly unreasonable they may be corrected by judicial review; that is, by public law remedies. A more difficult question is whether failure by a public body provides a private right of action to someone harmed (or not benefited) by the decision. While the general principles of duty of care apply (that is, proximity and whether it is fair and just to impose liability), there are several limitations on the liability of public bodies in negligence. This chapter first discusses the special common law principles applicable to the exercise of discretion by public bodies. It then considers specific problematic areas, including the difficulties involved in establishing duties of care by the emergency services before examining the effect of the Human Rights Act 1998 in establishing obligations owed directly by the state.