jimnoneill/paper-to-field-training huggingface dataset:
Peptide nucleic acid (PNA) binding-mediated induction of human -globin gene expression

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Peptide nucleic acids (PNAs) can bind to homopurine/ homopyrimidine sequences of double-stranded DNA targets in a sequence-specific manner and form [PNA] 2 /DNA triplexes with single-stranded DNA D-loop structures at the PNA binding sites. These D-loop structures have been found to have a capacity to initiate transcription in vitro . If this strategy can be used to induce transcription of endogenous genes, it may provide a novel approach for gene therapy of many human diseases. Human β globin disorders such as sickle cell anemia and β-thalassemia are very common genetic diseases that are caused by mutations in the β-globin gene. When γ-globin genes are highly expressed in sickle cell patients, the presence of high levels of fetal hemoglobin (HbF, α2γ2) can compensate for the defective β-globin gene product and such patients have much improved symptoms or are free of disease. However, the γ-globin genes are develop-mentally regulated and normally expressed at very low levels (>1%) in adult blood cells. We have investigated the possibility of inducing γ-globin gene expression with PNAs. Using PNAs designed to bind to the 5′ flanking region of the γ-globin gene, induction of expression of a reporter gene construct was demonstrated both in vitro and in vivo . More importantly, PNA-mediated induction of endogenous γ-globin gene expression was also demonstrated in K562 human erythroleukemia cells. This result suggests that induction of γ-globin gene expression with PNAs might provide a new approach for the treatment of sickle cell disease. PNA-induced gene expression strategy also may have implications in gene therapy of other diseases such as genetic diseases, cancer and infectious diseases.
SH595885.07FU

Field: Agricultural and Biological Sciences (Life Sciences)

UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
Planning practices of local governments based on the results of an empirical research

Field: Social Sciences (Social Sciences)

The purpose of this study is to explore the most important findings of the empirical research conducted amongst local governments of settlements in Hungary, in order to perform a comprehensive analysis on their practices and methods regarding planning. The primary research was conducted in the spring of 2013, with respondent local governments answering relevant questions by submitting a selfadministered questionnaire. The main purpose of the questionnaire survey was to find out whether the involved parties perform actual formal strategic and operative planning activities, and what kind of management planning methods – solutions already working and widespread in the business sector – they apply within the process of planning. In this study, we attempt to conduct a comprehensive analysis on modern planning systems and to appoint the fields that need to be improved, through the results of the questionnaire survey and our own experiences.
[Yogurt as source of lactose autodigestion].

Field: Medicine (Health Sciences)

Microorganisms in yogurt have the capacity of quantitatively digest in vivo in the small intestine the lactose from yogurt. The process of autodigestion of lactose in yogurt reduces both lactose maldigestion and lactose intolerance in lactase deficient individuals. Enzyme activity in yogurt depends upon the buffer capacity of the yogurt, microbial cells resistance to acid and enzymatic activity and to the effect of bile in the microbial cell that release beta-galactosidase activity. Lactose autodigestion capacity of yogurt is significantly reduced in pasteurized yogurt and it is also affected by the type and amount of microorganism that is added to milk and by the presence of fat. Yogurt intake represents an important food alternative for lactase deficient individuals.
Is there site for contrast ultrasound in the assessment of renal transplant complications

Field: Medicine (Health Sciences)

Poster: ECR 2015 / C-2147 / Is there site for contrast ultrasound in the assessment of renal transplant complications ? by: F. X. Aragon Tejada, C. Garcia Roch, J. M. Pinto Varela, J. J. Ciampi, L. M. Cruz Hernandez; Toledo/ES
Sexualities, Visual Arts and Power: Visual Pedagogies of the Feminine

Field: Arts and Humanities (Social Sciences)

This work is about the relations between sexualities, visual arts and power, taking in consideration the theorizations of Michel Foucault, mainly in respect to conceits like power and dissertation. Analyses like the feminine sexuality is put in dissertation through the images produced by occidental art, starting by a very particular masculine eye. In affirming that these images produce a pedagogy of the feminine, I pretend to contribute to the amplification of the analysis that take place in the teaching field of visual arts (and consequently, for the teaching formation on the area) that in the last years, through more recent methodological and theoretical tendencies, has been distinguishing the role of the images in education without, however, giving the proper attention to conceits like gender, sexuality and power.
Becoming Comanches

Field: Social Sciences (Social Sciences)

This chapter examines the experiences of the mostly young Hispanic male and female children who were taken as captives by the Comanche Indians. The author argues that male children were generally preferred, because of their potential value as horse herders. As the author shows, the captive experience ranged from chattel slavery to full incorporation into Comanche kinship networks. The likelihood of the captive achieving the latter status depended on several factors: the age of the captive, his or her ability to acquire Comanche customs and language, the disposition of the captive's master, and the overall resilience of the captive. Some captives, however, remained stigmatized their entire lives because of their captive origins.
The development of social security in America.

Field: Social Sciences (Social Sciences)

This article examines the historical origins and legislative development of the U.S. Social Security program. Focusing on the contributory social insurance program introduced in title II of the Social Security Act of 1935, the article traces the major amendments to the original program and provides an up-to-date description of the major provisions of the system. The article concludes with a brief overview of the debate over the future of the program, and it provides a summary assessment of the impact and importance of Social Security as a central pillar of the U.S. social welfare system.
Classification of Gastroenteropancreatic Neuroendocrine Tumors

Field: Medicine (Health Sciences)

Summary Gastroenteropancreatic neuroendocrine tumors are a heterogeneous group of tumors. There are several classification systems, and all of them have been validated.The article aims to summarize the existing classification systems of gastroenteropancreatic neuroendocrine tumors.A critical evaluation was based on the data available from existing studies.The classification of the European neuroendocrine tumor society is the one with the clinical benefits.The lack of unified classification systems creates incomplete epidemiologic data, leading to confusion among pathologists and clinicians.
Ultrasound‐Assisted Precise In Situ Decompression for Cubital Tunnel Syndrome

Field: Medicine (Health Sciences)

Objective To explore the effect of locating the ulnar nerve compression sites and guiding the small incision so as to decompress the ulnar nerve in situ on the elbow by high‐frequency ultrasound before operation. Methods A retrospective analysis was conducted on 56 patients who underwent ultrasound‐assisted in situ decompression for cubital tunnel syndrome from May 2018 to August 2019. The patients' average age was 51.13 ± 7.35 years, mean duration of symptoms was 6.51 ± 1.96 months, and mean postoperative follow‐up was 6.07 ± 0.82 months. Nine patients had Dellon's stage mild, 39 had stage moderate, and eight had stage severe. Ultrasound and electromyography were completed in all patients before operation. The presence of ulnar nerve compressive lesion, the specific location, and the reason and extent of compression were determined by ultrasound. A small incision in situ surgery was given to decompress the ulnar nerve according to the pre‐defined compressive sites. Results All patients underwent in situ decompression. The compression sites around the elbow were as follows: two in the arcade of Struthers, one in the medial intermuscular septum, four in the anconeus epitrochlearis muscle, five beside the cyst of the proximal flexor carpi ulnaris (FCU), and the remaining 44 cases were all from the compression between Osborne's ligament to the two heads of the FCU. The compression localizations diagnosed by ultrasound were confirmed by operations. Preoperative ultrasound confirmed no ulnar nerve subluxation in all cases. The postoperative outcomes were satisfactory. There was no recurrence or aggravation of symptoms in this group of patients according to the modified Bishop scoring system; results showed that 43 cases were excellent, 10 were good, and three were fair. Conclusions High‐frequency ultrasound can accurately and comprehensively evaluate the ulnar nerve compression and the surrounding tissues, thus providing significant guidance for the precise minimally invasive treatment of ulnar nerve compression.
Analisis Organizational Citizen Behavior (OCB) dan Komitmen Orginisasi terhadap Kinerja Pegawai Sdm PT Pelindo Multi Terminal Di Medan Dengan Self Efficacy Sebagai Variabel Intervening

Field: Business, Management and Accounting (Social Sciences)

The purpose of this study is to find out organizational citizen behavior (OCB), organizationalcommitment and self efficacy affect employee performance, to find out organizational citizen behavior (OCB)and organizational commitment affect self efficacy, to find out organizational citizen behavior (OCB) affectsemployee performance through self efficacy, and to find out whether organizational commitment affects employeeperformance PT Pelindo Multi Terminal through self efficacy. The population in this study is 178 employeesworking at PT Pelindo Multi Terminal. The sample in the study was 64 employees taken using the slovin formula.The data collection technique used in this study was carried out by distributing questionnaires. The analysistechnique in the study uses SmartPLS (Partial Least Square) starting from model measurement (outer model),model structure (inner model) and hypothesis testing. The results of the study show that organizational citizenbehavior (OCB), commitment to organization and self efficacy affect employee performance, organizationalcitizen behavior (OCB) and commitment to organization affect employee performance, organizational citizenbehavior (OCB) affects employee performance through self efficacy and commitment to organization affects theperformance of HR employees of PT Pelindo Multi Terminal through self efficacy.
'The European Minority Rights Regime: Analyzing the Role of Expert Knowledge in European Organizational Overlap'

Field: Social Sciences (Social Sciences)

Following the end of the Cold War minority rights became an important part of democratization in Central and Eastern Europe. With minority rights a condition in the EU‟s Copenhagen criteria of 1993, post-communist states were compelled to deal with minority issues as part of accession procedures. In the absence of EU acquis on minority rights, the OSCE and the Council of Europe have also played a role in monitoring candidates‟ compliance with the „minority condition‟ in the context of the 2004 and 2007 rounds of EU enlargement. This inter-organizational cooperation on minority rights constitutes the European minority rights regime. The aim of this paper is to explore the significant role of experts working for the three organisations who represent an epistemic community on minority rights in Europe. In doing so, we seek to expand Haas‟ (1992) conceptual framework on epistemic communities in two ways. First, we point to the variable influence of members within the epistemic community and build on Verdun‟s (1999) suggestion that the concept should allow for a potential hierarchy of experts. Second, we suggest that the concept needs to pay greater attention to the issue of a „consensual knowledge base.‟ Even though there is no international consensus on what constitutes a „national minority‟, we argue that an epistemic community can operate in contested policy issues when experts base their policy recommendations on a shared set of norms. In addition to these conceptual refinements, we show how an epistemic community helps drive an international regime. In this case, the epistemic community on minority rights helps the regime function as a process based on three constitutive elements: standard setting; standard implementation; and standard expansion. The article contributes to the literature on epistemic communities; international regimes; European organisations; and minority rights protection in Europe.
Cost-effectiveness of genetic testing in metastatic melanoma patients in the Phase-1 setting.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The pharmacokinetics, pharmacodynamics, safety, and tolerability of long-term administration of esmolol and landiolol, a new fast-acting cardioselective β-blocker, were compared for the first time in Caucasian subjects in a prospective clinical trial. Twelve healthy volunteers received landiolol and esmolol by continuous infusion for 24 hours in a randomized crossover study using a dose-escalation regimen. Blood concentrations of drugs and metabolites, heart rate, blood pressure, ECG parameters, and tolerability were observed for 30 hours and compared. Drug blood concentrations and areas under the curve were dose-proportional. The half life of landiolol (4.5 minutes) was significantly shorter than that of esmolol (6.9 minutes). Volume of distribution and total clearance were lower for landiolol. Heart rate reduction was faster and more pronounced with landiolol and retained throughout the administration period; effects on blood pressure were not different. Landiolol turned out to be superior to esmolol with respect to pharmacokinetic and pharmacodynamic profile and local tolerability.
Into the 21st Century

Field: Social Sciences (Social Sciences)

This chapter explores UK abortion debates in the 21st century. It describes new anti-abortion strategies which emerged in the 2000s and went beyond the familiar attacks on abortion providers. It demonstrates how issues such as foetal viability and calls for changes in pre-abortion counselling provision evolved as a consequence both of past anti-abortion activity and how pro-choice feminist actors have made their arguments. The chapter argues that counselling amendments are proposed because they undermine the association between a ‘right to choose’ and feminist politics and call into question the medical authority on which the Abortion Act 1967 was based.
Cronobacter spp. in Commercially Available Dried Food in Japan

Field: Immunology and Microbiology (Life Sciences)

A total of 140 samples of dried food sold in Japan were surveyed and tested for the presence of viable bacteria, distribution of coliform bacteria, and contamination with Cronobacter spp. The samples were purchased from retail stores in Tokyo and Kanagawa Prefecture. Out of the 140 samples tested, viable bacteria were found in 135 samples and coliform bacteria were found in 23 samples. Qualitative and quantitative testing revealed the presence of Cronobacter spp. in 35 (25.0%) and 11 samples (7.9%), respectively. The most commonly found Cronobacter species were C. sakazakii, with the next most common, in order, being C. muytjensii and C. turicensis. The actual numbers of Cronobacter species in the tested dried foods were low, but the widespread contamination particularly in dried herbs and vegetables was confirmed.
Uncommon Causes of Twinning: Complete Hydatidiform Mole with Coexistent Twin

Field: Medicine (Health Sciences)

A hydatidiform mole with a coexisting live fetus is a rare entity. Suspicion may arise when an ultrasound scan identifies a fetal pole along an abnormal placenta. The main issue is to differentiate between two diagnoses: a singleton pregnancy consisting of a partial hydatidiform mole with an abnormal triploid fetus which usually dies in utero during the first half of pregnancy; and a twin gestation consisting of a complete hydatidiform mole along with a coexisting live fetus (CMCF). The latter is extremely rare1-4, and management is challenging because the fetus may be viable. Information about this entity is scant. Moreover, only a few case reports of a twin gestation with a coexisting hydatidiform mole have accurately distinguished between a partial mole with a live fetus and CMCF. Although CMCF is associated with fetal survival, it carries a significant risk of severe complications such as pre-eclampsia, preterm delivery and development of persistent gestational trophoblastic tumor (GTT).
Friendship Through Social Media and Real Friends

Field: Arts and Humanities (Social Sciences)

본 논문의 목적은 소셜미디어를 통해서 형성되는 친구 사랑은 진정한 친구 사랑에 도달할 수 없음을 밝히는 것이다. 아리스토텔레스에 의하면 진정한 친구는 자신의 품성과 유사한 도덕적 가치에 대한 신념 때문에 친구를 사랑한다. 특히 아리스토텔레스는 친구 간의 상호 존중과 상호 사랑의 중요성을 강조한다. 온라인에서는 장점만을 선택적으로 제시함으로써 혹은 서로 다른 정체성을 혼합함으로써 자아를 세련되게 하는 일이 얼마든지 일어날 수 있고 실제로 일어난다. 특히 대화방처럼 익명인 환경에서는 더욱 그러하다. 이렇게 되면 서로의 사랑과 존중을 보장하기가 어렵게 된다. 또한 소셜 커뮤니티 사이트들은 대화 시점, 대화 방법, 대화 시간의 측면에서 현실과는 다른 방식으로 친구를 선택하는 것을 허용하므로 뜻하지 않게도 친구들은 특정한 상황에서만 의사소통할 수밖에 없다. 이렇게 되면 친구의 특성의 중요한 측면 혹은 잠재적으로 문제가 있는 측면을 놓친다. 결국 친구의 전체가 아니라 일부를 흠모하고 사랑하게 된다. 물론 알려지지 않은 부분이 알려진 특성만큼 도덕적일 수도 있다. 하지만 한정된 정보에 기반하고 있다는 단순한 사실이 가상공간에서의 친구 사랑으로부터 진정한 친구 사랑의 자격을 박탈한다. 결론적으로 온라인에서는 진정한 친구 사랑이 성취될 수 없다.
Biology of sexually transmitted diseases.

Field: Medicine (Health Sciences)

The clinical concept of sexually transmitted diseases describes a common mode of transmission of pathogens spanning the full spectrum of medical microbiology. These organisms have few common biologic characteristics aside from their ability to colonize or invade particular anatomic sites. New information on the biology of sexually transmitted pathogens has led to improved diagnostic and therapeutic strategies. Understanding that patients with sexually transmitted pathogens may be asymptomatic or may be simultaneously infected with multiple organisms has important implications for epidemiologic control of these diseases.
Effect of Nitrogen Levels and Planting Methods on Growth and Yield of Black Rice (Oryza sativa L.)

Field: Agricultural and Biological Sciences (Life Sciences)

Background: Compared to other types of rice, black rice has the highest protein content vitamins and minerals. Black rice contains essential amino acids like lysine, tryptophan; vitamins such as vitamin B1, vitamin B2, folic acid; and it is a good source of minerals including iron, zinc, calcium, phosphorus and selenium. Objectives: Impact of nitrogen levels and planting methods on black rice growth and production. Methods: A field experiment was conducted during kharif season of 2021, at crop research farm of Department of Agronomy at Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj in North Eastern plains of Eastern Uttar Pradesh. under randomized block design comprising of 9 treatments of which treatments (T1-T9) with different combination of nitrogen along with different planting meathods which are replicated thrice. Conclusion: The treatment Nitrogen at 75 kg/ha nitrogen + SRI method recorded maximum. Plant height (118.13 cm), number of tillers/hill (11.00), plant dry weight (31.62 g/plant), number of panicles per hill (10.83), number of grains per panicle (196.70), number of filled grains per panicle (116.33), grain yield (4.61 t/ha) and straw yield (11.38 t/ha). Because the findings are based on research conducted during a single season, they may be repeated for further confirmation.
How Can New Players Establish Themselves in Highly Institutionalized Labour Markets? A Belgian Case Study in the Area of Project‐Based Work

Field: Social Sciences (Social Sciences)

Abstract How can new players seeking to serve nonstandard worker categories (such as project‐based workers) establish themselves into labour markets that are highly institutionalized? This paper explores the case of SMart, a Belgian community‐based labour market intermediary that successfully developed solutions to better represent the interests of project‐based workers and secure their discontinuous careers. Using an organizational legitimacy approach, we find that labour market entry and growth involve different types of boundary‐crossing when addressing the needs of workers that do not fit into established categories. However, to justify boundary‐crossing, the new player must complement its pragmatic work on delivering new services and tools with conceptual (cognitive) and structural (moral) legitimation work.
Using visual requirements modeling to design human‐centric manufacturing systems for novel products – A comprehensive predictive case study

Field: Engineering (Physical Sciences)

Abstract Efficient production systems are necessary for the realization of products that fulfil customer needs and delivery requirements. However, the process of designing the production system has received little academic attention and today's manufacturing system design processes and architecture are still based on traditional engineering methods. This study covers a case study using visual requirements modeling for the design of a production system for a new product. A comprehensive prescriptive study was designed combined with attempts to verify the methods used. A total of six workshops, development of models to define requirements to select concepts, and two validation studies are documented. A total of 166 persons participated, and up to 15 persons participated in the validation workshops. The analysis shows that the method addressed several of the gaps identified in literature: (1) the lack of systematic and effective systems engineering design methods in production system design, and (2) the lack of inclusion of human aspects in the production system design. The gaps in the effectiveness of the methods remain to be fully evaluated, as the project is still running and will not be concluded until 2025. Recommendations for future work include exploring further the management mechanisms of systems engineering, which type of competences does the future engineer need and how production system design engineers can learn more from other disciplines.