jimnoneill/paper-to-field-training huggingface dataset:
Sumamed ® in the treatment of urogenital infections and sexually transmitted infections

Field: Medicine (Health Sciences)

Klinickom primjenom Sumameda® postignut je u svjetskim razmjerima bitan napredak u lijecenju urogenitalnih (UGI) i spolnoprenosivih (SPI) infekcija. Sumamed® je ucinkovit na najcesce bakterijske uzrocnike urogenitalnih i spolnoprenosivih infekcija, ima protuupalno i imunomodulacijsko djelovanje, djeluje na bakterijski biofilm. Sumamed® se primjenjuje jednom na dan, dobro se apsorbira nakon p.o. primjene, brzo se distribuira po organizmu, postiže visoke koncentracije, posebno u inficiranim tkivima, nakuplja se u lizosomima, fagociti ga prenose na mjesto infekcije. Ima produžen antimikrobni ucinak jer u tkivu i tjelesnim tekucinama postiže visoke i postojane koncentracije djelotvorne nekoliko dana nakon posljednje doze. Nuspojave su mu rijetke i blage. Sumamed® zadovoljava kriterije Svjetske zdravstvene organizacije za lijecenje SPI: 1) visoka djelotvornost (najmanje 95 % mikrobioloske ucinkovitosti) ; 2) niska cijena ; 3) prihvatljiva toksicnost i podnosljivost ; 4) mala mogucnost poticanja razvoja rezistencije uzrocnika na antimikrobna sredstva ; 5) jednostavna primjena ; 6) peroralna primjena ; 7) mogucnost primjene kod trudnica ; 8) ucinkovitost kod simptomatskih i asimptomatskih SPI ; 9) njegova primjena minimalno utjece na nacin života bolesnika ; 10) mala je mogucnost slucajnog propustanja uzimanja lijeka i 11) aktivan je na vise razlicitih uzrocnika SPI. Sumamed® je u dozi 1x1, 0 g p.o. lijek prvog izbora za lijecenje akutnog negonokoknog uretritisa i mukopurulentnog cervicitisa te za lijecenje klamidijske infekcije u trudnoci. U kombinaciji s metronidazolom u ukupnoj dozi od 3, 0 g p.o. preporucuje se za lijecenje perzistentnog uretritisa. U ukupnoj dozi od 3, 0 g p.o. Sumamed® se rabi u terapiji reaktivnog artritisa posredovanog C.trachomatis i U.urealyticum kao dio kombinirane terapije zdjelicne upalne bolesti. Sumamed® je djelotvoran i siguran lijek u lijecenju infekcije prostate uzrokovane C.trachomatis i U.urealyticum i to u ukupnoj dozi od 4, 5 g p.o. kroz 3 tjedna, primijenjen tijekom 3 dana tjedno u dozi od 1x500 mg na dan ili u ukupnoj dozi 4, 0 g p.o. kroz 4 tjedna primijenjen jednokratno 1x1, 0 g p.o. tjedno. Zakljucak: Sumamed®je ucinkovit na najcesce uzrocnike UGI i SPI. Ciljano djeluje na mjestu infekcije, siguran je za primjenu i jednostavan za uzimanje. S obzirom na niz godina osobnog klinickog iskustva i na stotine objavljenih klinickih studija, Sumamed® je lijek koji opravdano zaslužuje povjerenje lijecnika i bolesnika.
Results from a ICU follow up after severe traumatic brain injury

Field: Medicine (Health Sciences)

Spinal anaesthesia in a patient with Machado-Joseph DiseaseAuthors: F. Tavares; Pereira C.G.; Macieira J. IntroductionMachado Joseph Disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is an inherited neurodegenerative disorder characterized by progressive sensory and motor dysfunction. MJD is a rare disease and to the extent of our knowledge only 2 reports document the anaesthetic management of patients affected by this condition: one used an epidural anaesthesia and the other used a combined spinal-epidural technique with hyperbaric bupivacaine. We describe the third case.Clinical CaseA 65-year-old woman with MJD complicated with severe weakness in the arms and legs and diffuse polymialgias presented in the emergency setting for surgical repair of a bimalleolar fracture. Besides the neurodegenerative disorder she also had atrial fibrillation, bradycardia-tachycardia syndrome with an artificial pacemaker in place, hypertensive disease, obesity and dyslipidemia. After informed consent, a subarachnoid block was performed at the L3-L4 lumbar intervertebral space with 10mg of hyperbaric bupivacaine taking advantage of an expected lateralization of the blockade due to the positioning and so a more expectable cardiovascular stability. Sensory block reached the T10 level. The procedure was uneventful. Postoperative normal recovery occurred and the patient was discharged 2 days after. One month after the spinal anaesthesia no new neurological changes have been identified or reported when compared to the preoperative setting. DiscussionCentral nervous system disorders may be considered a relative contraindication to regional anaesthesia because of the risk and difficulty in determining the cause of eventual exacerbation of neurological deficits. Nevertheless, given that there are no large clinical studies supporting either type of anaesthetic management in MJD, we opted for regional blockade instead of general anaesthesia, taking into consideration the 2 uneventful cases already reported in literature and the cardiac disease of the patient. The regional technique allowed hemodynamic stability, an easier postoperative analgesic management and minimized post-procedure pulmonary complications such as hypoventilation, aspiration and hypoxia due to impaired neuromuscular function.Learning pointsNeuroaxial anaesthesia with hyperbaric bupivacaine can be a safe option for lower limb surgery in patients with MJD.
Trisecting non-Lagrangian theories

Field: Physics and Astronomy (Physical Sciences)

We propose a way to define and compute invariants of general smooth 4-manifolds based on topological twists of non-Lagrangian 4d N=2 and N=3 theories in which the problem is reduced to a fairly standard computation in topological A-model, albeit with rather unusual targets, such as compact and non-compact Gepner models, asymmetric orbifolds, N=(2,2) linear dilaton theories, "self-mirror" geometries, varieties with complex multiplication, etc.
The Real World of Medical Treatment of Pulmonary Arterial Hypertension―Small Evidence, but Heavy Cornerstone―

Field: Medicine (Health Sciences)

小児期PAHの薬物療法を行うにあたって，臨床医は小児は成人と異なり様々な特色があることを再認識しなければならない．すなわち，代謝酵素活性（p450など），受容体の濃度（密度）や感受性，器官の機能発達（特に腎臓と肝臓，心筋代謝），体脂肪の容積，蛋白（アルブミン）結合率，血中蛋白濃度，分散容積，薬物動態PKや薬力学PD，一定の年齢だけ反応する臓器（動脈管など），薬理遺伝子的背景， 遺伝子多型などによる個人差，特異体質，薬物相互作用，生体内活性物質（サイトカイン，ホルモン，伝達物質，カテコラミンなど）の影響である．特に小児期の重症疾患に対しては，“Right drug for the Right patient at Right time”という諺に準じて，その個人に見合った慎重なcase by caseの薬剤選択を心掛けなくてはいけない．小児期の肺高血圧治療薬には，NO-cGMP経路，PGI2-cAMP経路，エンドセリン受容体拮抗薬（ERA）の三大肺血管作動薬を使用する．小児では，世界的にもほとんどがoff-labelの状態で使用されている．しかし肺血管拡張作用以外の，細胞増殖抑制作用，線維化・肥大抑制作用，抗酸化ストレス・抗炎症作用を秘め，長期にわたって血管壁に抗リモデリン作用を発揮する薬剤を選択したい．また特発性（遺伝性，家族性）と二次性肺高血圧（左心不全，膠原病関連，呼吸器関連，肺血栓塞栓関連，そして新生児期肺高血圧など）では，3大治療薬が持つPDE5阻害作用，PGI2産生促進作用，エンドセリン受容体拮抗作用などの有効性もそれぞれ異なると予想される．本稿では，治療薬の小児期でのエビデンスを紹介しながら，最適の治療法を推奨したい．
An integrated model of team resilience: exploring the roles of team sensemaking, team bricolage and task interdependence

Field: Business, Management and Accounting (Social Sciences)

Purpose The contemporary organizational environment calls for work team members to be more resilient in the face of likely setbacks, which are routinely experienced at the workplace. In two separate studies of work teams, we examine the impact of team sensemaking on team bricolage and subsequently, on team resilience. These studies further investigate whether task interdependence moderates the mediation of team bricolage for the relationship between team sensemaking and team resilience. In brief, these two studies conceptualize and test the relevance of team sensemaking, team bricolage and task interdependence for team resilience. Design/methodology/approach A sample of 213 team members participated in the self-administered survey for Study 1. For Study 2, a second sample collected from 81 teams, elicited team-level data by consensus among team members. Findings Findings show that team sensemaking as an antecedent has a significant and positive impact on team resilience. The results also show how and when the relationship between team sensemaking and team resilience is facilitated through an underlying mechanism of team bricolage in the presence of task interdependence among team members. This research improves the understanding about the relationship between team sensemaking and team resilience by examining the underlying mechanism and boundary condition under which the relationship is the strongest. Practical implications These findings have important implications for human resource managers. In face of adverse events, team sensemaking plays a pivotal role as it can enable team members to have better situational awareness, communication and reflection. Team sensemaking can be further facilitated for improved team resilience by embedding bricolage and task interdependence components in the employee orientation, job description and training of potential and current employees. Originality/value These findings demonstrate that in the wake of adverse events, team sensemaking can play a pivotal role as it enables team members to have better situational awareness, communication and reflection. For team resilience, the findings imply that team sensemaking can be further facilitated by team bricolage in the presence of task interdependence in work teams. Thus, managers of modern work teams and organizations can sensitize team members about these aspects through employee orientation, job description and on and off job training activities.
Projective real calculi and Levi-Civita connections

Field: Mathematics (Physical Sciences)

Based on its central role in the framework of real calculi, the existence of the Levi-Civita connection for real calculi over projective modules is studied, with a special emphasis placed on the simple module of N-dimensional complex vectors over the algebra of complex N-by-N matrices. It is demonstrated that existence of the Levi-Civita connection in this case depends on the Lie algebra g of hermitian derivations, and necessary and sufficient conditions for the possibility of constructing a real calculus for which there exists a Levi-Civita connection are given in this case. Furthermore, in the general case of real calculi over projective modules, necessary and sufficient conditions for the existence of the Levi-Civita connection are given in terms of explicit projection coefficients.
The effect of melatonin on cardio fibrosis in juvenile rats with pressure overload and deregulation of HDACs

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The effect of melatonin on juveniles with cardio fibrosis is poorly understood. We investigated whether HDACs participate in the anti-fibrotic processes regulated by melatonin during hypertrophic remodeling. Abdominal aortic constriction (AAC) was employed in juvenile rats resulting in pressure overload-induced ventricular hypertrophy and melatonin was subsequently decreased via continuous light exposure for 5 weeks after surgery. AAC rats displayed an increased cross-sectional area of myocardial fibers and significantly elevated collagen deposition compared to sham-operated rats, as measured by HE and Masson Trichrome staining. Continuous light exposure following surgery exacerbated the increase in the cross-sectional area of myocardial fibers. The expression of HDAC1, HDAC2, HDAC3, HDAC4 and HDAC6 genes were all significantly enhanced in AAC rats with light exposure relative to the other rats. Moreover, the protein level of TNF-α was also upregulated in the AAC light exposure groups when compared with the sham. However, Smad4 protein expression was unchanged in the juveniles' hearts. In contrast, beginning 5 weeks after the operation, the AAC rats were treated with melatonin (10 mg/kg, intraperitoneal injection every evening) or vehicle 4 weeks, and sham rats were given vehicle. The changes in the histological measures of cardio fibrosis and the gene expressions of HDAC1, HDAC2, HDAC3, HDAC4 and HDAC6 were attenuated by melatonin administration. The results reveal that melatonin plays a role in the development of cardio fibrosis and the expression of HDAC1, HDAC2, HDAC3, HDAC4 and HDAC6 in cardiomyocytes.
Meat Puppets Live at Varsity Theater on 2007-11-10

Field: Arts and Humanities (Social Sciences)

Disc1 (55:00) 01. Attacked by Monsters 02. Touchdown King 03. Snow 04. Up On the Sun 05. Plateau 06. Look at the Rain 07. Lost 08. Flaming Heart 09. Severed Goddess Hand 10. My Baby's Gone 11. Station Disc 2 (39:33) 12. Sam 13. Comin' Down 14. Oh, Me 15. noodling 16. Lake Of Fire 17. crowd noise 18. Climbing 19. Maiden's Milk 20. Maiden's Milk (con't) 21. Backwater
Adverse Events from Emergency Physician Pediatric Extremity Radiograph Interpretations: A Prospective Cohort Study

Field: Medicine (Health Sciences)

Abstract Objectives We determined how often emergency physician pediatric musculoskeletal (MSK) radiograph interpretations were discordant to that of a radiologist and led to an adverse event (AE). We also established the variables independently associated with this outcome. Methods This prospective cohort study was conducted in an urban, tertiary care children's emergency department (ED). We enrolled children who presented to an ED with an extremity injury and received radiographs. ED physicians documented their radiograph interpretation, which was compared to a radiology reference standard. Patients received telephone follow‐up and had institutional medical records reviewed in 3 weeks. An AE occurred if there were clinical sequelae and/or repeat health care visits due to a delay in correct radiograph interpretation. Results We enrolled 2,302 children (mean [±SD] age = 9.0 [4.4] years; 1,288 (56.0%) male]. Of these, 180 (7.8%; 95% confidence interval = 6.8 to 9.0) ED physician discordant interpretations resulted in an AE. Specifically, there were no negative clinical outcomes; however, relative to cases diagnosed correctly at the index ED, patients whose fracture was not initially identified encountered 77.2% more subsequent ED visits, while those falsely diagnosed with a fracture experienced 41.5% additional orthopedic clinic visits. Odds of an ED discrepant interpretation was significantly higher if a physician’s pretest probability of a fracture was ≤ 20% versus> 20% (adjusted odds ratio [aOR] = 1.6), patient’s pain score was ≤ 2 versus> 2 (aOR = 1.6), and injury was located in a joint versus other location (aOR = 1.7). Conclusions Emergency physician discordant pediatric MSK radiograph interpretations that resulted in an AE occurred with regular frequency in a pediatric ED setting. AEs were primarily an increase in subsequent health care visits. Importantly, a low clinical suspicion for a fracture or injury located in the joint were risk factors for ED physician discordant interpretations.
The Meaning of “Money” in Cognitive Linguistics

Field: Arts and Humanities (Social Sciences)

이 연구의 목적은 관용표현에서 나타나는 ‘돈’의 은유 의미를 분석하고 특성을 논의하는 것이다. ‘돈’은 동전, 지폐와 같이 구체물을 가리키는 단어로 비용이나 재산, 물건의 가치를 나타내는척도로 사용된다. 우리는 일상에서 겪는 경제적 경험을 통해 다양한 ‘돈’과 관련된 표현들을 사용한다. 이런 표현들에는 언중들이 가지고 있는 ‘돈’에 대한 개념이 드러난다. 사람들은 돈을 ‘물’과 같이 흐르고 고이고 새어 나가는 것이라고 여기기도 하고 돈은 아주 힘이강하여 사람의 통제를 벗어날 뿐만 아니라 사람에게 큰 영향을 미친다고 생각하기도 한다. 하지만돈은 사람이 필요에 의해 사용하는 도구이므로 물건이나 먹을 수 있는 음식이라고 생각한다. 또‘돈’은 사람, 동물, 식물과 같이 살아 있는 대상으로 인식된다. 그래서 사람과 같은 기능을 하거나잡을 수 있는 동물, 뿌리를 내려 살 수 있는 식물로 표현된다. 우리의 삶에서 기본적이고 중요한돈은 벌고 사용할 때 부정적이어서는 안 된다. 이런 도덕적 가치는 돈은 더러워질 수 있고 독을가지고 있을 수 있어 세탁할 수 있는 것으로 개념화한다. 이러한 ‘돈’에 대한 사람들의 생각은 언어에서도 나타난다. 이 연구에서는 ‘돈’이 포함된 관용표현을 분석하여 사람들이 가지고 있는 ‘돈’에 대한 보편적인 생각을 살펴보았다.
Fail-safe element using thin film parametron

Field: Engineering (Physical Sciences)

In addition to a memory apparatus, one of the applications of thin Permalloy wires is a fail-safe element using a thin film parametron (T.F.P.). "Parametron" has been known as the failsafe element in automatic control fields. The T.F.P. is more suitable to the fail-safe element than a ferrite one with regard to speed, stability, and size. Thin Permalloy wires used are 81 Ni-Fe alloy with a thickness of 1 μm electrodeposited onto copper wires with a diameter of 0.47 mm. The uniaxial field-induced anisotropy was in the peripheral direction, and the anisotropy field was about 200 At/m. Output voltages of the T.F.P. are more stabilized than those of a ferrite parametron. This is one of the reasons why the T.F.P. is recommended as a fail-safe element. A test set with a twin binary counter of seventeen digits using about 300 T.F.P. fail-safe elements has been operated satisfactorily with an exciting current of 0.2 A rms and 50 kHz clock.
Annotated List of Leafhoppers (Homoptera: Cicadellidae) from Two Ohio Fens with a Description of a New Chlorotettix

Field: Agricultural and Biological Sciences (Life Sciences)

Leafhoppers from Springfield and Prairie Road Fens, Clark County, Ohio, were surveyed in 1986. Sixty-eight species, representing 14 subfamilies, were recorded from these two fens, including a new state record. In addition, a new species, previously confused with Chlorotettix limosus DeLong and Cartwright, is described.
The fuel of discontent? Transport poverty risks and equity concerns in French urban peripheries

Field: Social Sciences (Social Sciences)

A range of accessibility indicators has been developed in the past decade to evaluate equity in transportation within urban areas. Some studies have attempted to incorporate them in transport poverty metrics, focussing on insufficient access to general services and employment. While accessibility measures coupled with statistics have been effective in assessing immediate households’ vulnerability, we argue that an analysis of their adaptive capacity could contribute to a better information of local policies in the long term. This paper aims to develop a methodology for mapping transport poverty risks at the metropolitan scale, while studying the relation between urban segregation and the transport divide. We use the case study of Lyon to operationalise our method and find evidence of vulnerability patterns previously identified in the sociological literature. Beyond the sensitivity of households living in the first-crown neighbourhoods and the growing exposure of medium-income families settling in peripheral municipalities, we emphasise the importance of using mixed methodologies to better capture households’ needs and mobility choices within suburban environments. We conclude by discussing shortcomings and future developments of our research.
Continuous infusion of frusemide in refractory oedema.

Field: Medicine (Health Sciences)

Continuous infusion of frusemide in refractory oedemaFrusemide is a potent loop diuretic with an impressive dose-response relationship over a wide dose range.Nevertheless, probably because of concern over possible toxicity,' the attainment of an effective dose may be delayed in patients with oedema refractory to conventional dosing.We report here the frequency with which high-dose frusemide was prescribed in a group of medical inpatients and then describe a small series of patients who were given continuous infusion of frusemide using a constant infusion pump.
[A case of primary leiomyosarcoma of the ureter].

Field: Medicine (Health Sciences)

A 60-year-old woman was admitted to our hospital with pain in the left flank. Retrograde pyelography, computed tomographic scan, and magnetic resonance imaging demonstrated left hydronephrosis due to a 7 cm retroperitoneal mass involving the left ureter. Left nephroureterectomy and partial resection of the mesentery revealed a primary ureteral leiomyosarcoma. Three months postoperatively, the patient received systemic chemotherapy (CYVADIC; cyclophosphamide, vincristine, adriamycin and DTIC) for a recurrent tumor. Two courses of chemotherapy reduced the tumor by nearly 60%. Then we performed surgery in an attempt to resect the residual disease. However, the tumor continued to progress and the patient died approximately one year after diagnosis.
Mean field difference games: McKean-Vlasov dynamics

Field: Mathematics (Physical Sciences)

We study a class of mean field stochastic games in discrete time and continuous state space. Each player has its own individual state evolution described by a stochastic difference equation which depends not only on the control of the corresponding player but also on the states of the other players. Considering the specific structure of aggregate drift and diffusion terms, we use classical asymptotic indistinguishability properties to prove a mean field convergence in distribution. The methodology is extended to multiple classes of players, each class satisfying the asymptotic indistinguishability property, and a propagation of chaos result is obtained over the hull trajectory. Finally, we derive combined backward-forward equations that characterize the mean field equilibria for finite horizon problems.
Composting of tomato wastes and sheep manure: An eco-friendly waste valorisation for enhancing the environmental sustainability in Souss Massa region (Morocco)

Field: Agricultural and Biological Sciences (Life Sciences)

Each season, a huge amount of crop residues is regenerated by horticultural production. The main type of wastes are tomato stalks, leaves and axillary buds which are subsequently the result of crop operations like trimming and plants trellising and uprooting. The landfilling of corps residues is a serious problem that need to be solved. Therefore, the valorisation of these organic wastes by composting is a simple way for suitable management and the produced compost could be used as an organic amendment to satisfy the crop growth needs and agronomic soil requirements. The aim of the study is to investigate the impact of the mixing proportion of tomatoes residues and sheep manure using an experimental biocomposter of capacity 220 L with passive aeration system. Two different mixing ratios were set-up on volume basis: R1 (2/3 tomato plant residues ‘’TPR” + 1/3 sheep manure “SM”) and R2 (1/3 tomato plant residues ‘’TPR” + 2/3 sheep manure “SM”) and two controls CTRP (1/1 tomato plant residues ‘’TPR”) and CSM (1/1 sheep manure ‘’SM’’). Parameters such as Temperature, pH, EC, Carbon-to-nitrogen ratio, mineral and organic nitrogen, potassium and phosphorous were monitored for a period of 60 days. According to the results, tomato wastes proportion is negatively correlated to the Germination Index (GI) of the final compost, the nitrogen and the organic matter loss. After 9 weeks of composting, GI was 87%, 91%, 92%, and 95% respectively for CTRP, R1, R2 and CSM. Tomato plant residues are not adequate for composting alone, and could limit the efficiency of the process.
Returns of parental education on children’s development by cultural inheritance and ethnic background

Field: Economics, Econometrics and Finance (Social Sciences)

Abstract

Parents’ education and the time they spend with their children are crucial for child development and human capital formation. We examine the returns of parental education on children’s cognitive devel- opment and academic performance, and how these effects vary by ethnicity. Using longitudinal data, random e↵ects models and Augmented Value Added models, we identify persistent test score gaps by ethnicity and by parental education which feed into later education and labor market outcomes. The gaps remain after controlling for socio-demographic characteristics and ability. Asian children outperform due to larger time investments, selection into better schools and parenting styles. Indigenous children tend to underperform due to a complex interplay of lower financial resources, lower time investments and parenting styles. On average, parental education facilitates the intergenerational transmission of human capital across ethnic groups in similar ways. However, quintile regressions identify diminished returns to parental education for Indigenous children at the upper end of the test score distribution. Our results have policy implications with respect to structural barriers and equity in the education system. JEL classifications: I24, I26, J15, J18