jimnoneill/paper-to-field-training huggingface dataset:
Data from A Phase II Trial of Pembrolizumab and Vorinostat in Recurrent Metastatic Head and Neck Squamous Cell Carcinomas and Salivary Gland Cancer

Field: Medicine (Health Sciences)

<div>AbstractPurpose:<p>This clinical trial combined pembrolizumab and vorinostat in recurrent/metastatic squamous cell carcinomas of the head and neck (HN), and salivary gland cancer (SGC).</p>Patients and Methods:<p>Patients with progressing incurable HN and SGC, Eastern Cooperative Oncology Group (ECOG) ≤1, no prior immunotherapy, RECIST1.1 measurable disease, and normal organ function were eligible. Pembrolizumab 200 mg was given intravenous every 21 days, and vorinostat 400 mg given orally 5 days on and 2 days off during each 21-day cycle. Primary endpoints were safety and objective response rates.</p>Results:<p>From November 2015 to August 2017, 25 patients with HN and 25 SGC were enrolled. Median age was 61 (range, 33–86) years, 39 (78%) were male, 21 (62%) were never smokers, and 27 (54%) had ECOG 0. In HN, 13 (52%) were p16+ oropharynx. Most common SGC histologies were adenoid cystic 12 (48%), acinic cell 3 (12%), and mucoepidermoid 3 (12%). Adverse events (AEs) in all patients were: 27 (54%) with grade ≥ 1 and 18 (36%) with grade ≥ 3. The most common AEs in all patients were renal insufficiency in seven, (14%), fatigue in six, (12%), and nausea in three (6%). There were three (12%) deaths on study. Responses in HN were complete response (CR) 0, partial response (PR) eight (32%), and stable disease (SD) five (20%). Efficacy in SGCs was CR 0, PR four (16%) in one lymphoepithelioma-like carcinoma, two acinic cell, one adenoid cystic, and SD 14 (56%). In the HN group, median follow-up (mFUP) was 12.6 months, median overall survival (mOS) was 12.6 months, and median progression-free survival (mPFS) was 4.5 months. In SGC, mFUP was 13.1 months, mOS was 14.0 months, and mPFS was 6.9 months.</p>Conclusions:<p>This combination demonstrated activity in HN, with fewer responses in SGC. Toxicities were higher than reported with pembrolizumab alone.</p></div>
ChemInform Abstract: Enantioselective Synthesis of Spiro[cyclohexane‐1,3′‐indolin]‐2′‐ones Containing Multiple Stereocenters via Organocatalytic Michael/Aldol Cascade Reactions.

Field: Chemistry (Physical Sciences)

Abstract The reaction of oxindoles with dialdehydes in the presence of PRS provides the title compounds with moderate diastereoselectivity and excellent enantioselecvtivity.
Influence of Digital Marketing Techniques on Consumer Behavior for Mobile Services

Field: Business, Management and Accounting (Social Sciences)

The aim of this research was to explore how different digital marketing techniques, such as video marketing, internet advertising, email marketing, and SEO, impact consumer behavior regarding mobile services offered by Zain Telecom in Amman, Jordan. A simple random survey method was employed, with 445 questionnaires distributed to Zain Telecom customers in Amman. After excluding incomplete responses, 405 completed questionnaires were analyzed using multiple regression, descriptive analysis, and reliability testing. The findings indicate that all the independent variables significantly influence consumer behavior in purchasing mobile services, with email marketing exhibiting the strongest impact. Consequently, the study suggests an increased investment in email marketing techniques
Combined lateral gaze palsy and unilateral internuclear ophthalmoplegia in midbrain and high pons haemorrhage: clinical study of a case

Field: Medicine (Health Sciences)

The authors report a case of right midbrain and high pons haemorrhage with complete external ophthalmoplegy, except bilateral convergence, voluntary and automatic-reflex abduction of the left eye and adduction of this eye with vestibulo-ocular reflex (one-and-a-half syndrome). There is voluntary-automatic dissociation of the eyelids motricity and the vertical gaze. Still, there is sensitive-motor hemiplegia at left and asterixis.
Artificial Intelligence‐Guided Identification of IGFBP7 as a Critical Indicator in Lactic Metabolism Determines Immunotherapy Response in Stomach Adenocarcinoma

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ABSTRACT Due to considerable tumour heterogeneity, stomach adenocarcinoma (STAD) has a poor prognosis and varies in response to treatment, making it one of the main causes of cancer‐related mortality globally. Recent data point to a significant role for metabolic reprogramming, namely dysregulated lactic acid metabolism, in the evolution of STAD and treatment resistance. This study used a series of artificial intelligence‐related approaches to identify IGFBP7, a Schlafen family member, as a critical factor in determining the response to immunotherapy and lactic acid metabolism in STAD patients. Computational analyses revealed that a high lactic metabolism (LM) state was associated with poor survival in STAD patients. Further biological network‐based investigations identified a key subnetwork closely linked to LM. Machine learning techniques, such as random forest and least absolute shrinkage and selection operator, highlighted IGFBP7 as a crucial indicator in STAD. Functional annotations showed that IGFBP7 expression was linked to important immune and inflammatory pathways. In vitro experiments demonstrated that silencing IGFBP7 suppressed cell proliferation and migration. Furthermore, heightened susceptibility to several chemotherapeutic drugs was linked to elevated IGFBP7 levels. In conclusion, this work sheds light on the mechanisms by which the lactate metabolism‐related indicator IGFBP7 affects the tumour immune milieu and the response to immunotherapy in STAD. The results point to IGFBP7 as a possible therapeutic target and predictive biomarker for the treatment of STAD.
P.Oxy.VI 864 Poetical Fragment, P.Oxy.VI 864

Field: Arts and Humanities (Social Sciences)

[Text Description:] Ends of lines from an entire column, apparently from an anthology of poetry. ❧ [Text or Publication Number Note:] P.Oxy.VI 864, P.Oxy. 864, Spurlock 1914.21.0001 ❧ [Excavation Description:] Excavated by archaeologists, including Bernard Pyne Grenfell and Arthur Surridge Hunt, at an ancient rubbish dump near Oxyrhynchus in Egypt (28°32'N 30°40'E, modern el-Bahnasa). ❧ [Medium:] Papyrus ❧ [Script Note:] Greek ❧ [Physical Object Description:] Papyrus manuscript, 15.8 x 6.8 cm.
The efficacy of Ahmed glaucoma valve drainage devices in cases of adult refractory glaucoma in Indian eyes

Field: Medicine (Health Sciences)

Aim: To evaluate the efficacy of Ahmed glaucoma valve (AGV) drainage devices in cases of adult refractory glaucoma in Indian eyes. Settings and Design: Retrospective interventional case series study. Materials and Methods : Fifty two eyes of 32 patients of refractory glaucoma in the age group of 35 to 60 years who underwent AGV implantation with or without concomitant procedures from January 2003 to Jan 2007 were studied. Of these, 46 eyes (88%) had undergone filtering surgery earlier whereas remaining eyes underwent primary AGV implantation following failure of maximal medical therapy. The follow up ranged between 12 months to 48 months Results: Eighteen eyes (35%) had undergone phacoemulsification with AGV implantation, penetrating keratoplasty (PK) with AGV and intraocular lens (IOL) implantation in 13 eyes (25%), AGV over preexisting IOL in eight eyes (15%). AGV implantation alone was done in six (11%) eyes. Anterior chamber (AC) reconstruction with secondary IOL and AGV was performed in the remaining eyes. The mean intra ocular pressure (IOP) decreased from 36.3 ± 15.7 mm Hg to 19.6 ± 9.2 mm Hg. Complete success as per criteria was achieved in 46 eyes (88%). None of the eyes had failure to maintain IOP control following AGV. Conclusion: The AGV resulted in effective and sustained control of IOP in cases of adult refractory glaucoma in intermediate follow up.
Predictors of the Timing and Number of Antenatal Care Visits among Unmarried Compared To Married Youth in Uganda Between 1995 And 2011

Field: Health Professions (Health Sciences)

Abstract Introduction Inadequate use of maternal health services among the youth remains a serious health challenge in Uganda. The low use of maternal health services among youth partly explains the persistence high maternal mortality rate in the country. Yet, improved use of maternal health services by the youth would help reduce maternal deaths in the country. Therefore, this study examines predisposing and enabling factors associated with the timing and the number of antenatal care visits among unmarried compared to married youth aged 15-24 years between 1995 and 2011 in Uganda. Methodology Two-level binary logistic and linear regression models with district as a second level of analysis were conducted on pooled data of the 1995, 2000/01, 2006 and 2011 Uganda Demographic and Health Surveys. This analysis was among 581 unmarried, compared to 5,437 married youth, aged 15-24 years. Results Only 16% of unmarried youth and 18% of married youth had ANC in the first trimester. Education was the only factor that was significantly associated with early use of antenatal care among unmarried youth. Whereas high education was associated with higher odds of using antenatal care in the first trimester among married youth (OR=1.30, 95%CI=1.08-1.57), it was associated with late start among unmarried youth (OR=0.56, 95%CI=0.31-0.98). Higher parity, protestant membership and residence in eastern region were associated with late start of antenatal care, while access to radio and television, and education level of the husband were associated with higher odds of early use of antenatal care among married youth. Overall, married youth were more likely to have more frequent antenatal care visits than unmarried youth. Among both groups, higher educational attainment and greater access to radio were associated with frequent antenatal care use. Residing in western region was associated with fewer antenatal care visits among both married and unmarried youth. Access to newspaper was associated with more antenatal care visits among married youth only. Conclusion This study presents the individual level predisposing and enabling factors that are important predictors of the use of antenatal health care services among youth that will guide policy to reduce maternal deaths among youth in Uganda.
Trapped Field of a Bitter-like HTS Magnet Using Partial Multi-Pulse Magnetization

Field: Physics and Astronomy (Physical Sciences)

The Bitter-like high temperature superconducting (HTS) magnet, stacked by ReBCO annular plates, has the advantages of no current leads and bulky or expensive power supply, so that it is attractive for development of strong magnetic field with full HTS materials. In this paper, a zero-field cooling method is proposed to supply power for the Bitter-like HTS magnets. The background field is generated by a pulsed current source and a solenoidal coil, which is doubly wound by an insulated copper wire. This paper focuses on the characteristics between the height of solenoidal coils and the magnetic field induced in the Bitter-like magnet.The solenoidal coil functioning as primary winding is inserted coaxially into the Bitter-like HTS magnet, and Bitter-like HTS magnet is equivalent to the secondary winding. The power of the current source is provided by a pulsed current source with triangular waveform. The solenoidal coil was designed and analyzed for pumping energy into the Bitter-like HTS magnet. The relationship between the height of the solenoid and the excitation duration was obtained experimentally in 77 K at the specified pulse current amplitude and frequency. The results conforms the pumping principles and feasibility for HTS magnet with persistent current mode.
The Effect of Education, Income on Economic Growth of Sukabumi Regency

Field: Economics, Econometrics and Finance (Social Sciences)

This study explores the relationship between education, income, and economic growth in Sukabumi Regency, a district in Indonesia. A mixed method approach was used, including a survey of 300 respondents and interviews with interviewees. The survey results show that higher levels of education and income are associated with greater involvement in economic activity and perceptions of economic growth. Interviews revealed several factors influencing this relationship, including government policies, the business environment, and social and cultural attitudes toward education and employment. This study shows that there is a need for targeted and effective policies to encourage education and income growth, as well as broader social and cultural changes to support economic growth in Sukabumi District.
Countertransference and its Influence on Judgements of Fitness for Analysis

Field: Psychology (Social Sciences)

In responding to an earlier draft of this paper, some colleagues challenged the premise that persons can be meaningfully differentiated into one or another of such personality organizations, raising larger issues concerning the pitfalls of diagnostic labeling.2 Once we pin a label on a person, or accept a label as given—and this can begin, of course, with the label, 'patient'—we may be led easily to think of the person as some-thing-known. And, this may stimulate in our thoughts, a process which begins with depriving the patient of his personhood and ends by negating his therapeutic need to be understood as fully as possible in his own terms. It is, therefore, necessary always to monitor our diagnostic thinking lest we reify our patients or our psychoanalytic constructs. (Feiner 1970), (Schafer 1979) Still, mindful of such cautions, I find the distinction between these two character constellations meaningful, substantively and heuristically. I have found the following to be true, in my own practice, and in an even larger number of cases reported to me in supervision and in case seminars: (1) that there are some patients whose transference patterns in the therapeutic interaction closely correspond to those Kohut has described in connection with the narcissistic personality organization (Kohut 1971), (1978); and (2) that there are other patients whose transference patterns correspond to those described by Kernberg (Kernberg 1975) in connection with the borderline personality organization; and (3) that the therapist's countertransference experience in response to the transference behavior of one or the other type of patient corresponds as well to that which has been described by these writers.3 It is, in fact, the quality of the transference/countertransference matrix which mainly determines whether I think of a patient as having a borderline or a narcissistic character structure or as being in a borderline or narcissistic ego state. I believe these distinctions to be important only in so far as they guide the therapist in his handling of the treatment process. This brings me to a brief discussion of the essential disagreement between Kernberg and Kohut and of some points of disagreement which I have with each. Kernberg disputes Kohut's conception of the narcissistic personality
The correlation of the severity of polysomnography with clinical assessment in cases of adult OSA in a tertiary hospital

Field: Medicine (Health Sciences)

<p class="abstract"><strong>Background:</strong> Now days increasing number of people with sleep related breathing disorders especially obstructive sleep apnea are reporting every day in our institute, which is a tertiary referral centre. The objective was to correlate between clinical assessment andpolysomnographic features in an obstructive sleep apnea patient.</p><p class="abstract"><strong>Methods:</strong> A total number of 60 cases were analyzed retrospectively and those who were already clinically assessed and diagnosed as OSA by AHI&gt;5/h in overnight PSG study. The clinical history, body mass index, Epworth sleepiness scale score and full night polysomnograpic data were obtained for all 60 cases. The age and gender differences in OSA cases were analyzed. The correlations between the BMI, ESS score, AHI, oxygen saturation sleep apnea, Epworth sleeps scale and apnea hypopnea index were explored. </p><p class="abstract"><strong>Results:</strong> Of the 60 cases OSA were analyzed, the mean (SD) age was 36.62 (±11.90) years and the men was mostly affected 96.7% than women only 3.3%. Of 60 cases, 30% of patients having mild form, 25% of patients moderate form, 45% of patients having severe form. The obese patients affected more 83.3% (50/60) than normal only 10% (6/60). The clinical symptom were analyzed by ESS score the normal 18.3%, mild 18.3%, moderate 28.3% and severe 35%. The mean oxygen saturation and heart rate of OSA patients were 72.35 (±11.47) and 69.90 (±15.26) respectively.</p><p><strong>Conclusions:</strong> The BMI and ESS score were positively correlated with severity of OSA. The oxygen saturation and heart rate were negatively correlated with OSA. </p>
Impact of Streptococcus agalactiae Challenge on Immune Response, Antioxidant Status and Hepatorenal Indices of Nile Tilapia: The Palliative Role of Chitosan White Poplar Nanocapsule

Field: Veterinary (Health Sciences)

A new insight into the synthesis of the herbal plant (White poplar, Poplus alba) leave extract using chitosan nanocapsule was studied. The in vitro antibacterial activity of chitosan white poplar nanocapsule (CWPNC) against Streptococcus agalactiae (S. agalactiae) was determined. About 120 fish were categorized for 7 days into four groups. The first and second (CWPNC) groups were treated with 0 mg/L and 3 mg/L CWPNC in the water, respectively, without being challenged; the first group was a control. The third (S. agalactiae) and fourth (CWPNC + S. agalactiae) groups were treated with 0 and 3 mg/L CWPNC, respectively, and challenged with S. agalactiae (0.5 × 107 CFU/mL). The obtained results revealed that CWPNC had an in vitro antibacterial activity against S. agalactiae. Moreover, S. agalactiae infection caused a significant elevation (p < 0.05) in the lipid peroxidation (malondialdehyde) and hepatorenal biomarkers, as well as the lowest significant (p < 0.05) survival rate (33.33%). Moreover, a significant depletion (p < 0.05) in the level of antioxidants (catalase and superoxide dismutase) and the immune indicators (immunoglobulin, lysozyme activity, and complement 3) were the consequences of S. agalactiae infection. Treatment of the infected fish with 3 mg/L CWPNC alleviated these bad circumstances.
1 Myocardial Lesion Depth with Circular Electroporation Ablation Running title: Wittkampf et al.; Lesion depth with circular electroporation

Field: Medicine (Health Sciences)

Background- Recently, we demonstrated feasibility and safety of circular electroporation ablation in porcine pulmonary vein ostia, but the relationship between the magnitude of the application and lesion dimensions still is unknown. Methods and Results- An in vivo porcine study was performed on left ventricular epicardium submerged under 10 mm blood, using devices that mimic a 20 mm diameter 7F circular ablation catheter. Model D contained 10 separate electrodes while model M consisted of one circular electrode. Ablations were performed at 50, 100, and 200 joules with model D and at 100 joules with model M. Lesion dimensions were measured after 3 weeks survival. All applications resulted in smooth voltage waveforms demonstrating the absence of vapor globe formation, arcing and a pressure wave. Applications up to 100 joules with model D resulted in separate lesions under the electrodes. At 200 joules, continuous deep circular lesions were created despite the use of separate electrodes. There was a significant relationship between applied current and median lesion depth with a slope of 0.17 mm/Ampere. At 100 joules there was no difference in lesion depth or width between model D and M. The electrodes and ablation site directly after
Creation of a Rabbit Model of Rib Distraction Osteogenesis

Field: Medicine (Health Sciences)

Our study aimed to create a rabbit model of rib distraction osteogenesis, for use in treatment of rib defects and research on the process of distraction osteogenesis. Ten rabbits were subjected to unilateral osteotomy and a specific distractor was installed. The distractors were normally designed. Two rabbits died from anesthesia. Eight female rabbits underwent rib osteotomies, and lateral distraction devices were implanted. Three days postoperatively, distraction commenced on one side in each rabbit, by 0.5 mm twice a day for 80 days. Four rabbits each were sacrificed 15 and 30 days later, respectively, and the osteogenic and contralateral ribs were removed for histomorphometric examination. Normal development of distraction osteogenesis was observed, and the structure of newly formed bone was the same as that of other parts of the rib. Histomorphometric and gross tissue appearance of the areas subjected to distraction osteogenesis were the same as the other parts of the rib. We successfully established an animal model of rib distraction and documented the entire process of extension. Rib distraction was performed by 0.5 mm twice a day. Following a fixed period of 30 days, the biological characteristics of the distracted and contralateral normal rib showed no difference. Moreover, the distracted rib had curvature.
Ways for Improving Results of Wildcat Drilling in the Dnieper-Donets Depression

Field: Earth and Planetary Sciences (Physical Sciences)

This analysis is based on drilling data for 38 structures. Computer processing was used. For the Lower Carboniferous pay zones the causes of the low result s were: unfavorable structural conditions for 31 wells (39%), absence of reservoirs in 11 wells (14%), unfavorable section in 26 wells (32%). In 7 wells the cause was unclear, and 5 wells w ere shut down for technical reasons. In sediments of the Middle Carboniferous the low results were due to unfavorable structural position for 4 wells (2 0%), absence of reservoirs in 8 wells (40%), unfavorable section in 5 wells (25%); the cause was unclear for 1 well, and 2 was sh ut down for technical reasons. The causes of low results for the Lower Permian and Upper Carboniferous showed a similar distribution. The main reason for the poor results of wildcat drilling is an inadequate level seismic surveying. In mapping low-amplitude highs, errors are caused by insufficient knowledge of horizontal velocity gradients. Therefore, the volume of parametr ic drilli ng should be increased to a density of 1 well per 200-400 sq km. Preliminary calculations suggest that implementation of the r ecommendations can increase the success of wildcat drilling in the Dnieper-Donets depression by 10-15%. © Petroleum Geology: A digest of Russian literature on Petroleum Geology, 2013
Madame de Genlis

Field: Arts and Humanities (Social Sciences)

Madame de Genlis Get access M. R. M. R. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s4-XI, Issue 282, 24 May 1873, Page 433, https://doi.org/10.1093/nq/s4-XI.282.433b Published: 24 May 1873