jimnoneill/paper-to-field-training huggingface dataset:
Effi cacy of macrolides antibiotics in the treatment of asthma acute attack through Meta-analysis

Field: Medicine (Health Sciences)

Objective To assess the efficacy of macrolides antibiotics in the treatment of asthma acute attack through Meta-analysis of published pertinent articles scientifically. Methods Pertinent literatures on macrolides antibiotics related with asthma acute attack were searched in PubMed, CNKI and WeiPu Data. According to the inclusion and exclusion criteria, the data were extracted and the methodological quality was evaluated. Then the Meta-analysis was conducted by Review Manager 5.0 software, and the sensitivity analysis and publication bias were evaluated at the same time. Results Six randomized controlled trials were included, and the result combined OR values and 95% CI was that macrolides antibiotics could improve the symptom of asthma acute attack [OR=3.10, 95%CI(1.71, 5.64), Z=3.71, P=0.000 2]. Conclusion Macrolides antibiotics can significantly improve the clinical efficacy of asthma acute attack.
Protein sequence design on given backbones with deep learning

Field: Computer Science (Physical Sciences)

Abstract Deep learning methods for protein sequence design focus on modeling and sampling the many- dimensional distribution of amino acid sequences conditioned on the backbone structure. To produce physically foldable sequences, inter-residue couplings need to be considered properly. These couplings are treated explicitly in iterative methods or autoregressive methods. Non-autoregressive models treating these couplings implicitly are computationally more efficient, but still await tests by wet experiment. Currently, sequence design methods are evaluated mainly using native sequence recovery rate and native sequence perplexity. These metrics can be complemented by sequence-structure compatibility metrics obtained from energy calculation or structure prediction. However, existing computational metrics have important limitations that may render the generalization of computational test results to performance in real applications unwarranted. Validation of design methods by wet experiments should be encouraged.
Écrire et réécrire au cycle 3 : l'effet des mots clés sur la réécriture, avec et sans assistance informatique

Field: Social Sciences (Social Sciences)

Write and rewrite in cycle 3 (8 to 11 years old) : the effect of keywords on rewriting, with and without computer's help. Jacques Crinon, Denis Legros & Brigitte Marin, Coditexte / CNRS-ESA7021 (ParisVIII), IUFM de Créteil. The present study faits within the framework of researches that allowed perfecting a software to help rewriting and to compare rewritings of stories of Personal experience by pupils of cycle 3 whether they benefited or not of computerized help. The pupils of the group that take notes in the computerised database of textual resources rewrite more than the pupils of the group that benefits of textual resources presented on paper. Besides, their additions, more important on the semantic level, belong to the macrostructure of the text. We tried to understand the reasons of these results by analysing the role taken by the access to the resources through keywords. 112 pupils, shared in four groups, have written, then rewritten a story : the textual resources were presented on paper or on a computer ; the consultation was done in a linearly process or with the help of keywords describing these texts' universe. We have compared the number and the «relevance » of the additions made according to the group. The results do not show any quantitative differences between the participants of the groups that used keywords and the others. On the other hand the groups with keywords produce additions less relevant when using paper resources and more relevant when using computer resources. The number of texts available and the possibility for the pupil to find resource texts compatible with the text he is writing seem determining. The presence of keywords allows, on the computer, the efficient circulation through an important corpus. So is the function of the tool underscored : open new possibilites, in a configuration where interact numerous factors.
Optimal path and tracking control of an autonomous VTOL aircraft

Field: Engineering (Physical Sciences)

This study presents a simple algorithm for motion-planning and design tools for tracking in a vertical take-off and landing (VTOL) aircraft. The proposed motion-planning procedure is based on the solution of a linear algebraic equation. The resulting schemes are useful for flight control of an autonomous VTOL aircraft in case the objective is to drive the system from a given state to a prescribed target and when a reference path should be followed. In particular the proposed controller ensures the accomplishment of a required control task while in addition, a selected quadratic index of performance is minimized. The solution to the suboptimal control problem is simple since a functional which measures the controller performance, reduces to a quadratic form and hence, the extremum is associated with a minimum point of a function of several variables
Improved automated kinetic determination of uric acid in serum by use of uricase/catalase/aldehyde dehydrogenase.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract The enzymatic determination of serum uric acid by use of uricase, catalase, and aldehyde dehydrogenase according to Haeckel [J. Clin. Chem. Clin Biochem. 14, 101 (1976)] showed interferences from ethanol-converting enzymes, which are present in some patients' sera. We have identified these enzymes as alcohol dehydrogenase isoenzymes. Among other substances, a mixture of pyrazole and oxalate can be used to eliminate these interferences. This inhibitor system gives good results when used in the automated kinetic uric acid determination, as is shown by a comparison with the manual assay for uric acid according to Kageyama [Clin. Chim. Acta 31, 421 (1971)].
Smart Fish Farm based on IoT As Monitoring to Reduce the Number of Death in Guppy Fish

Field: Engineering (Physical Sciences)

During the transition from dry season to rainy season or vice versa, very high temperature fluctuations often occur, causing large number of deaths in guppy fish farming. The death of this guppy fish is also triggered by water conditions that are not maintained. Therefore, a system that can monitor water conditions in real time without being limited by distance, and that can cope the drastic temperature changes is needed. If water conditions can be monitored in real time, of course, the guppy fish in aquarium or tank will become healthier, well-maintained and will produce the best quality guppy fish. For this reason, the researcher makes a system that is able to monitor the condition of water in the aquarium to reduce the number of deaths in guppies. The researcher conducts trials using Fuzzy Mamdani method of three input variables from water temperature sensor, pH sensor and turbidity sensor which defuzzification result shows crips output value at 44.63. That result puts water condition in “Fair” level, and when it is matched with the calculation result of matlab r2013a using Fuzzy Mamdani, the result is 44.8 which is not far different. The result of this study is a smart fish farm system that can monitor water conditions in aquariums or tanks, such as: feeding time, checking and controlling temperature, monitoring water pH, monitoring water turbidity levels, lights control that can automatically turn on and off with room lighting indicators, and drain when the water is turbid. This smart fish farm system is made with an Arduino microcontroller that is connected to the internet based on Internet of Things (IoT) and the Mamdani Fuzzy Logic method. This smart fish farm system can also store records with platforms from Thingspeak and MitApp for the mobile applications making.
Analysis and System Construction of Ideological and Political Education Teaching Mode Based on Wechat Platform

Field: Computer Science (Physical Sciences)

To solve the problem that students can only passively receive the education content under the traditional ideological and political teaching mode, and the effect is low, this paper develops the ideological and political teaching system based on Wechat platform combined with information technology. It uses Java language to write the system, and through Servlet, Hiberbat, Web Service and other technologies to complete the system framework, and to achieve the information processing of Ideological and political education. At the same time, in the registration part of the text content of the teaching materials, the paper puts forward the scheme of developing digital learning resources of Ideological and political teaching materials combined with augmented reality technology. In the design work, the data storage and management of the program are also designed in the database. Finally, through the programming communication interface and software development architecture, the specific function coding of the system is realized. After testing, all functions of the platform can be used normally and meet the design requirements.
Serum thrombomodulin—a reliable marker of disease activity in systemic lupus erythematosus (SLE): advantage over established serological parameters to indicate disease activity

Field: Medicine (Health Sciences)

SUMMARY To date no specific serological parameter is available to assess disease activity in SLE. Soluble serum thrombomodulin is a new marker of endothelial cell injury and vasculitis. The objective of this study was to compare in vivo soluble thrombomodulin as marker of disease activity in SLE with established and recent serological parameters. One hundred and twenty-four sera of 30 patients with proven SLE with different disease activities were tested for serum levels of thrombomodulin, intercellular adhesion molecule-1 (ICAM-1), E-selectin, vascular cell adhesion molecule-1 (VCAM-1), IL-2R, IL-6, IL-10, dsDNA by ELISA and dsDNA additionally by radioimmunoassay (RIA). C-reactive protein (CRP), complement component C3, IgG, creatinine, anti-nuclear antibodies (ANA) and intermediate filament antibodies were measured by standard laboratory tests. The clinical disease activity was evaluated by the Systemic Lupus Activity Measure (SLAM). Correlations of the different serological SLE disease activity parameters with the SLAM scores revealed the highest significance for serum thrombomodulin (correlation coefficient 0.82). This was further confirmed by the intra-individual analysis of follow-up sera. In addition, a moderate correlation could be found for IL-6, IL-10, ICAM-1, CRP and erythrocyte sedimentation rate (ESR). In summary, soluble thrombomodulin is the most important serological parameter of disease activity in SLE currently available, as shown by the in vivo studies. Soluble thrombomodulin might be a valuable serological parameter for therapeutical considerations.
BENEFICIAL MICROORGANISMS USED İN THE PRODUCTION OF DAIRY PRODUCTS

Field: Agricultural and Biological Sciences (Life Sciences)

Beneficial microorganisms used in the production of dairy products are among the biological factors that provide special assistance in the food industry. These microorganisms are not only fed to ensure the natural curdling process of milk, but also add flavor, aroma, consistency and storage services to the products. Lactic acid bacteria and yeasts are among the most commonly used groups, which break down milk sugar - lactose - into lactic acid. This process both prevents the development of pathogenic microflora and allows products to be stored for a longer period of time. In addition, microorganisms with probiotic properties affect human health, restore its microflora, strengthen the immune system and participate in the synthesis of some vitamins. The role of microorganisms in different dairy products is different. For example, in the production of yogurt, Lactobacillus bulgaricus and Streptococcus thermophilus bacteria act in a symbiotic relationship, completing the fermentation process within 4–6 hours at a temperature of 42–45°C. Both lactic acid bacteria and yeasts are involved in the production of kefir, which gives it a carbonated, specific taste; this process lasts 18–24 hours. Microorganisms such as Lactococcus lactis and Lactobacillus helveticus can continue to grow in cheese, continuing to grow. This control is responsible for the taste, texture and aromatic properties of the curd. The stages of activity of microorganisms are divided into adaptation, reproduction, stabilization and maturation periods. The adaptation phase lasts up to 2 hours, the activity of reproduction decreases at pH, the acidity stabilizes for stabilization, and with maturation, it is present in products such as cheese and kefir for a long time. Beneficial microorganisms used in the production of dairy products play an important role in ensuring both food safety and consumer health. The correctness and application of microorganisms in this dairy industry provide not only technological, but also biological and medical assistance.
Personalized Biometrics of Physical Pain Agree with Its Psychological Perception by Participants with Sensory Over Responsivity

Field: Neuroscience (Life Sciences)

The study of pain requires a balance between subjective methods that rely on self-reports and complementary objective biometrics that ascertain physical signals associated with subjective accounts. There are at present no objective scales that enable the personalized assessment of pain, as most work involving electrophysiology rely on summary statistics from a priori theoretical population assumptions. Along these lines, recent work has provided evidence of differences in pain sensations between participants with Sensory Over Responsivity (SOR) and controls. While these analyses are useful to understand pain across groups, there remains a need to quantify individual differences more precisely in a personalized manner. Here we offer new methods to characterize pain using the moment-by-moment standardized fluctuations in EEG brain activity centrally reflecting the person&rsquo;s experiencing temperature-based stimulation at the periphery. This type of gross data is often disregarded as noise, yet here we show its utility to characterize the lingering sensation of discomfort raising to the level of pain, individually, for each participant. We show fundamental differences between the SOR group in relation to controls and provide an objective account of pain congruent with the subjective self-reported data. This offers the potential to build a standardized scale useful to profile pain levels in a personalized manner across the general population.
IL-35 (Interleukin-35) Suppresses Endothelial Cell Activation by Inhibiting Mitochondrial Reactive Oxygen Species-Mediated Site-Specific Acetylation of H3K14 (Histone 3 Lysine 14)

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Objective— IL-35 (interleukin-35) is an anti-inflammatory cytokine, which inhibits immune responses by inducing regulatory T cells and regulatory B cells and suppressing effector T cells and macrophages. It remains unknown whether atherogenic stimuli induce IL-35 and whether IL-35 inhibits atherogenic lipid-induced endothelial cell (EC) activation and atherosclerosis. EC activation induced by hyperlipidemia stimuli, including lysophosphatidylcholine is considered as an initiation step for monocyte recruitment and atherosclerosis. In this study, we examined the expression of IL-35 during early atherosclerosis and the roles and mechanisms of IL-35 in suppressing lysophosphatidylcholine-induced EC activation. Approach and Results— Using microarray and ELISA, we found that IL-35 and its receptor are significantly induced during early atherosclerosis in the aortas and plasma of ApoE (apolipoprotein E) knockout mice—an atherosclerotic mouse model—and in the plasma of hypercholesterolemic patients. In addition, we found that IL-35 suppresses lysophosphatidylcholine-induced monocyte adhesion to human aortic ECs. Furthermore, our RNA-sequencing analysis shows that IL-35 selectively inhibits lysophosphatidylcholine-induced EC activation-related genes, such as ICAM-1 (intercellular adhesion molecule-1). Mechanistically, using flow cytometry, mass spectrometry, electron spin resonance analyses, and chromatin immunoprecipitation-sequencing analyses, we found that IL-35 blocks lysophosphatidylcholine-induced mitochondrial reactive oxygen species, which are required for the induction of site-specific H3K14 (histone 3 lysine 14) acetylation, increased binding of proinflammatory transcription factor AP-1 in the promoter of ICAM-1, and induction of ICAM-1 transcription in human aortic EC. Finally, IL-35 cytokine therapy suppresses atherosclerotic lesion development in ApoE knockout mice. Conclusions— IL-35 is induced during atherosclerosis development and inhibits mitochondrial reactive oxygen species-H3K14 acetylation-AP-1–mediated EC activation.
The Female Reproductive Tract Microbiome—Implications for Gynecologic Cancers and Personalized Medicine

Field: Medicine (Health Sciences)

The microbial colonization of the lower female reproductive tract has been extensively studied over the past few decades. In contrast, the upper female reproductive tract including the uterine cavity and peritoneum where the ovaries and fallopian tubes reside were traditionally assumed to be sterile under non-pathologic conditions. However, recent studies applying next-generation sequencing of the bacterial 16S ribosomal RNA gene have provided convincing evidence for the existence of an upper female reproductive tract microbiome. While the vaginal microbiome and its importance for reproductive health outcomes has been extensively studied, the microbiome of the upper female reproductive tract and its relevance for gynecologic cancers has been less studied and will be the focus of this article. This targeted review summarizes the pertinent literature on the female reproductive tract microbiome in gynecologic malignancies and its anticipated role in future research and clinical applications in personalized medicine.
Knowledge and Utility: Implications for the Sociology of Knowledge

Field: Social Sciences (Social Sciences)

In this paper an attempt is made to widen the scope of the current debate about the possibility of subjecting scientific knowledge to sociological analysis. It is suggested that in identifying scientific knowledge as epistemologically special, and as exempt from sociological analysis, sociologists have tended to make two basic assumptions; namely that scientific theories can be clearly validated by successful practical application and that the general theoretical formulations of science do regularly generate such practical applications. These assumptions, as customarily interpreted, pose a major challenge for any sociological analysis which views scientific knowledge as the contingent outcome of interpretative and context-dependent social acts. It is argued, however, in some detail, that the validity of these assumptions is doubtful and that the usefulness of science is no barrier to the full sociological analysis of scientific knowledge.
[A case of subarachnoid hemorrhage with different BIS values observed between the right and left forehead].

Field: Medicine (Health Sciences)

We experienced a case of subarachnoid hemorrhage with different BIS values observed between the right and left forehead. A 71-year-old woman was scheduled for endovascular coiling. She had been already intubated and showed little response to painful stimulation without sedation (Japan coma scale; III-200). Anesthesia was induced and maintained with propofol. BIS monitoring was started from the right forehead before anesthetic induction (r-BIS), and additional monitoring from the left side was started after induction (1-BIS). When the operation was started, 1-BIS was 40 and r-BIS was 30. During the operation, 1-BIS was always higher than r-BIS; 1-BIS was 49 +/- 10 and r-BIS was 37 +/- 7 (mean +/- SD). The difference between r-BIS and 1-BIS was more than 10 for 68% of operation time. Since abnormal EEG pattern was observed, we concluded that abnormal EEG influenced BIS value, and 1-BIS after anesthesia was higher than that of her actual conscious level. EEG of a patient with acute stroke sometimes shows an abnormal pattern. Anesthesiologists should keep in mind the possibility that an abnormal EEG might influence BIS value.
ISOLATION AND CHARACTERIZATION OF FUNGI ASSOCIATED WITH PROCESSED COW SKIN (GANDA) SOLD IN BIRNIN KEBBI NEW CENTRAL MARKET, KEBBI STATE -

Field: Immunology and Microbiology (Life Sciences)

This research was carried outto isolate and identify fungi associated with processed cow skin (Ganda or Ponmo) sold in Birnin Kebbi new centralmarket.A total of Thirty (30) piece samples of Ponmo were purchased from different sales points labelled as; A, B and C. Screening for fungal contamination was conducted using standard procedure during the month of August, 2019. Five fungi were isolated and identified from “Ganda” namely; Aspergillus niger, Mucor species, Aspergillus flavus, Penicillum species and Rhizopus stolonifer. The predominant fungi isolated was Aspergillus niger with 48% and the least was Mucor species with 9%. The results of mean spore forming unit obtained ranged from 1.2x106 to 8.0x 106Sfu /ml in all the samples analyzed. It could be concluded, that Ganda sold in the study area, were found to be contaminated with various fungi which might be harmful to human when consumed in large amount over a long period of time. Proper care should be taken in handling, display in the market places and processing of Ponmo/Ganda as some of these fungi are known to have negative impacts on humans as they produce mycotoxins. This findings recommended for a proper hygiene practice, sanitary environment, modern technology in preserving and distribution of Ganda in Birnin Kebbi new central market, Kebbi State.
Plasma Bilirubin and Bromsulfophthalein Clearance During Simulated High Altitude in Unanesthetized Rats.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The simulated altitude of 28,000 ft in a decompression chamber was found to increase the 3 2-minute plasma levels of injected bilirubin and BSP by about 28 and 53% respectively in the unanesthetized rat in which vena cava polyethylene cannulas had been implanted. The implications of these findings for the bilirubinemia of chronic anoxic hypoxia have been discussed.
The Drive for War and the Pogroms of November 1938: Testing Explanatory Models

Field: Arts and Humanities (Social Sciences)

The Drive for War and the Pogroms of November 1938: Testing Explanatory Models Get access Herbert A. Strauss Herbert A. Strauss Search for other works by this author on: Oxford Academic Google Scholar The Leo Baeck Institute Year Book, Volume 35, Issue 1, January 1990, Pages 267–278, https://doi.org/10.1093/leobaeck/35.1.267 Published: 01 January 1990