jimnoneill/paper-to-field-training huggingface dataset:
Transition us together: development of a parent-centered toolkit to support adolescents with rheumatic disease transition to adult care

Field: Health Professions (Health Sciences)

Abstract Objectives While the transition period can be a difficult time for adolescents with chronic health conditions, parents also face challenges in understanding their changing role and how to support their children. To date, minimal interventions have focused on supporting and empowering parents during this period. Methods We co-created a toolkit with and for parents to help prepare them for their child’s transition to adult care. The toolkit was created using an iterative process of reviewing existing resources with integrating feedback from rheumatology patients and parents. Input was sought from the Family and Youth Advisory Councils at McMaster Children’s Hospital in Hamilton, Canada. Results The two components of the toolkit include a Transition Road Map and a Parent Guide to Transition. Five domains of transition readiness were established as pillars of the Road Map. Within each domain, a checklist to achieve self-management was established. The Parent Guide was developed to highlight important information including defining transition, outlining differences between pediatric and adult care, and providing tips on helping and supporting adolescents. Conclusions A Parent Toolkit directed at the Transition from Pediatric to Adult Rheumatology Care was developed and underwent extensive review with multiple stakeholders. Ongoing research on its impact on transition readiness is underway.
On the interaction of a moving hollow vortex with an aerofoil, with application to sound generation

Field: Physics and Astronomy (Physical Sciences)

A hollow vortex in the form of a straight tube, parallel to the z -axis, and of radius a , moves in a uniform stream of fluid with velocity U in the x -direction, with U small compared with the sound speed c . This steady flow is disturbed by the presence of a thin symmetric fixed aerofoil. With a change of x -coordinate, the problem is equivalent to that of a moving aerofoil cutting through an initially fixed vortex in still fluid. The aim of this work is to determine the resulting perturbed flow, and to estimate the distant sound field. A detailed calculation is given for the perturbed velocity potential in the incompressible flow case, for the linearized equations in the limit of small aerofoil thickness. A formally exact solution involves a four-fold integral and an infinite sum over all mode numbers. For the important special case where the vortex tube has small radius a compared with the aerofoil width, the deformed vortex is characterized by a hypothetical vortex filament located at the ‘mean centre’ x¯ ( z , t ), y¯ ( z , t ) of the tube. Explicit results are given for x¯ ( z , t ), y¯ ( z , t ) for the case where the aerofoil has the elementary rectangular profile; results can then be obtained for more general and realistic cylindrical aerofoils by a single integral weighted with the derivative of the aerofoil thickness function. Finally the distant sound field is estimated, representing the aerofoil by a distribution of moving monopole sources and representing the effect of the deformed vortex in terms of compressible dipoles along the mean centre of the vortex.
Non-verbal speech analysis of parent child dialog

Field: Computer Science (Physical Sciences)

Over the recent years, human emotion recognition has been in top priority for researchers from various domains. Despite the use of various physio psychological parameters as an index to human emotions, speech signal is considered as an important parameter that reflects the emotional state of a human being. The importance of automated emotion recognition models can be accredited to the growing demand for socially intelligent systems. This dissertation work focuses on analysing speech signals by extracting non-verbal speech features in order to recognize the emotions and classify them accordingly. The research work has been carried out using the audio data recorded from different parent child conversations by providing them with visual stimuli in the form of pictures. The features are extracted from the audio data using MATLAB and OpenSMILE toolbox. The extracted features are classified into five classes as labelled in the experiment using WEKA Tool. In order to achieve higher classification accuracy, different pairs of classes were chosen based on K-means clustering algorithm and binary classification is performed. The scatter plots are visually represented and classification accuracy for various classifier algorithms have been tabulated. The ranking of classifiers has been done based on their classification accuracy.
Commercialising subsistence farmers: a benefit or detriment to the poor?

Field: Social Sciences (Social Sciences)

The commercialisation of subsistence farmers: a benefit or detriment to the poor? \nThe aim of this study is to understand if rural households in Swaziland are benefiting from \nengaging in commercial outgrower schemes. The process of commercialising subsistence \nfarmers has been one of the government of Swaziland’s strategic attempts to lift rural \nhouseholds out of poverty by raising their income levels. I explore some of the socioeconomic \nfactors that are imposed on rural households, bringing into question whether or \nnot this strategy is a viable poverty alleviation policy. \nIn Sub-Saharan Africa, agriculture has been central to economic development through the \npromotion of the export of crops and raw material. Its profitable potential provides a \nvehicle for using land in rural areas for poverty alleviation and rural development \nstrategies. Commercialising subsistence farmers has the potential to offer the prospect of \nraising incomes, improving welfare, food security and nutritional status that could \notherwise have been worse. However, this transition (from subsistence to commercial) in \nagricultural activities in rural communities can also have detrimental consequences such as \nreduce income and threaten household food security. I therefore ask the question: How \nhave rural households benefited from engaging in commercial agriculture? \nIn this study I explore the process of commercialising subsistence farmers as a form of \nrural development. To achieve this, I have carried out a case study analysis of a rural \ncommunity in Swaziland called Mafucula, which has currently been involved in the \ncommercial agriculture of sugarcane for the last six years. Empirical data was obtained \nthrough semi-structured interviews with 30 households in this community. My findings \ndemonstrate that with six years into commercial agriculture, this community has not \nbenefited from this venture and continues to face the ongoing struggle of poverty.
Effects of Chameleon Dispense-to-Plunge Time on Grid Characteristics, Sample Distribution, and Complex Denaturation of the Neisseria gonorrhoeae Ribonucleotide Reductase Inactive Complex

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Journal Article Effects of Chameleon Dispense-to-Plunge Time on Grid Characteristics, Sample Distribution, and Complex Denaturation of the Neisseria gonorrhoeae Ribonucleotide Reductase Inactive Complex Get access Talya S Levitz, Talya S Levitz Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA Search for other works by this author on: Oxford Academic Google Scholar Edward J Brignole, Edward J Brignole Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USAMIT.nano, Massachusetts Institute of Technology, Cambridge, MA, USA Search for other works by this author on: Oxford Academic Google Scholar Ivan Fong, Ivan Fong SPT Labtech, Melbourn Science Park, Cambridge Rd, Melbourn, UK Search for other works by this author on: Oxford Academic Google Scholar Michele C Darrow, Michele C Darrow SPT Labtech, Melbourn Science Park, Cambridge Rd, Melbourn, UK Search for other works by this author on: Oxford Academic Google Scholar Catherine L Drennan Catherine L Drennan Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USADepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USAHoward Hughes Medical Institute, Cambridge, MA, USA Corresponding author: cdrennan@mit.edu Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 28, Issue S1, 1 August 2022, Pages 1238–1242, https://doi.org/10.1017/S1431927622005141 Published: 01 August 2022
Effect of the fixed combination of irbesartan 300 mg/hydrochlorothiazide 25 mg on the circadian blood pressure profile in essential hypertension

Field: Medicine (Health Sciences)

Most hypertensive patients included in morbidity and mortality trials needed two or more drugs to achieve a sustained blood pressure reduction. Therefore, safe combinations using higher doses of antihypertensive drugs are frequently required to control blood pressure. The aim of the present study is to evaluate the magnitude of the effect of a once-daily fixed combination of irbesartan 300/hydrochlorothiazide 25 mg on the circadian blood pressure profile in essential hypertensive patients not controlled with full-dose single therapy or low-dose combined therapy. After a 1-week wash-out period, 57 patients (28m, 29f) aged 45-78 years showing a mean daytime-BP (from 10:00 to 20:00 hours) higher than 135/85 mmHg were treated with irbesartan 300/HCTZ 25 for 12 weeks. Twenty-four hour ambulatory blood pressure monitoring (ABPM) was performed at the end of the wash-out period and during the last week of treatment. After treatment a significant reduction in the average values of both clinic and ambulatory BP values was observed in the whole group of 57 patients (from 146.0± 11.0 to 123.3± 13.3 mmHg, p<0.001 for 24-h SBP; and from 89.8± 8.2 to 76.5± 9.4 mmHg, p< 0.001 for 24-h DBP). The response rate was 94.7% (ABPM lowering > 5 mmHg of either 24h-SBP or 24h-DBP values) and the control rate 68.4% (daytime BP< 135/85 mmHg) at the end of treatment. The average lowering of ambulatory SBP and DBP at peak was 25.2± 14.5 and 14.7± 9.5, respectively, whereas the lowering at trough was 22.3± 18.3 and 12.3± 10.9 mmHg, respectively. The trough-to-peak ratio (T/P) of the group was 0.92 for SBP (0.97 in responders) and 0.84 for DBP (0.89 in responders). The smoothness index (SI) calculated as the average of all individual values was 1.66± 1.0 for SBP (1.76± 0.9 in responders) and 1.29± 0.8 for DBP (1.48± 0.6 in responders). Only 7 side effects in 6 patients were reported. No metabolic changes were observed and no patient discontinued the study. The fixed combination of irbesartan 300/HCTZ 25 administered once-daily was very effective in reducing 24-hour blood pressure and very well tolerated, preserving the circadian profile as showed by T/P ratios very close to 1 and SI > 1 for both SBP and DBP.
Implementation of a CMOS FM RX front-end with an automatic tunable input matching network

Field: Engineering (Physical Sciences)

본 논문에서 2개의 다른 특성을 갖는 FM 안테나들을 사용할 수 있도록 자동 변환 매칭 네트워크를 갖는 CMOS FM 수신기 프론트엔드 구조를 제안하였고 이를 65nm CMOS 공정을 이용하여 설계하였다. 제안된 FM 수신기는 높은 주파수 선택 특성을 갖는 임베디드 안테나를 사용 시 FM 전체 주파수 밴드에서 일정한 수신감도를 유지하기 위해서 저 잡음 증폭기의 입력 매칭 회로의 공진 주파수를 채널 주파수에 따라 가변이 가능하도록 구현하였다. 구현된 FM 프론트엔드의 시뮬레이션 결과는 약 38dB 전압이득, 2.5dB 이하의 잡음 지수 특성, -15.5dBm의 IIP3 선형성 특성을 보이고 1.8V 전원에 3.5mA 전류를 소모한다. In this paper, we propose a CMOS FM RX front-end structure with an automatic tunable input matching network and implement it using a 65nm CMOS technology. The proposed FM RX front-end is designed to change the resonance frequency of the input matching network at the low noise amplifier (LNA) according to the channel frequency selected by a phase-locked loop (PLL) for maintaining almost constant sensitivity level when an embedded antenna type with high frequency selectivity characteristic is used for FM receiver. The simulation results of implemented FM front-end show about 38dB of voltage gain, below 2.5dB of noise figure, and -15.5dBm of input referred intercept point (IIP3) respectively, while drawing only 3.5mA from 1.8V supply voltage including an LO buffer.
Synthesis of 5-fluoro-7,12-dimethylbenz[a]anthracene-3,4-dione: nucleophilic displacement of fluorine in polyaromatic hydrocarbons

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 5-fluoro-7,12-dimethylbenz[a]anthracene-3,4-dione: nucleophilic displacement of fluorine in polyaromatic hydrocarbonsYounus M. Sheikh, Nnochiri Ekwuribe, Balram Dhawan, and Donald T. WitiakCite this: J. Org. Chem. 1982, 47, 22, 4341–4344Publication Date (Print):October 1, 1982Publication History Published online1 May 2002Published inissue 1 October 1982https://pubs.acs.org/doi/10.1021/jo00143a035https://doi.org/10.1021/jo00143a035research-articleACS PublicationsRequest reuse permissionsArticle Views282Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Early Quintessence and the CMB

Field: Physics and Astronomy (Physical Sciences)

We examine the cosmic microwave background (CMB) anisotropy for signatures of early quintessence dark energy -- a non-negligible quintessence energy density during the recombination and structure formation eras. In contrast to a $Λ$CDM cosmology, early quintessence leads to a larger suppression of structure growth. Because of this influence on the clustering of dark matter and the baryon-photon fluid, we may expect to find trace signals in the CMB and the mass fluctuation power spectrum. In detail, we demonstrate that suppressed clustering power on small length-scales, as suggested by the combined Wilkinson Microwave Anisotropy Probe (WMAP) / CMB / large scale structure data set, is characteristic of early quintessence.
Numerical and experimental assessment of a typical brazilian footbridge

Field: Engineering (Physical Sciences)

Abstract For the range of medium spans, around 30 to 40m, composite footbridges are getting popular in Brazil. This kind of structure consists on longitudinal steel truss beams providing support for a concrete deck usually made of precast elements. Typical examples of these structures may be found in many cities in Brazil, especially in Brasilia where a large number of highways demanded a significant set of footbridges. Due to the amount of this kind of composite footbridges in Brazil, studies concerning their mechanical behavior are required in order to ensure pedestrian's safety. For this end, in this paper, a typical Brazilian composite footbridge located in Brasilia is analyzed by means of experimental tests and computational modeling. The focus is the determination of natural frequencies and mode shapes. Strategies to correctly obtain the vertical modes are also discussed since vertical vibration is the main vibration problem expected for the tested footbridge. The obtained results showed that structural balance between stiffness and mass leads to natural frequencies out of the critical frequency range excited by pedestrians in normal use, although the idea was not to measure how these parameters, mass or stiffness, could influence the model. Moreover, Finite Element models were evaluated comparing complexity versus accuracy to predict modal parameters.
Atomic displacements and atomic motion induced by electronic excitation in heavy-ion-irradiated amorphous metallic alloys

Field: Materials Science (Physical Sciences)

In amorphous metallic alloys irradiated with swift heavy ions, electronic excitation induces atomic displacements at the beginning of the irradiation and anisotropic growth above an incubation fluence. The authors provide here an extensive review of their data on amorphous Fe85B15 (including work that is already published), as well as a general description of the topic. Samples were irradiated at various temperatures (20 K, 90 K, 223 K) with a large variety of high-energy (GeV) heavy ions (Ar to U). The atomic rearrangements occurring during irradiation were studied by in situ electrical resistance experiments. The influence of the irradiation geometry as well as of a uniaxial stress applied to the sample was investigated. The whole set of data is accounted for with a two-hit phenomenological model allowing one to extract physical parameters. A description of the ion-target interaction on the basis of the Coulomb explosion mechanism is also provided.
Impact of Salinity on Growth and Physiological Responses of Striped Catfish Pangasionodon hypophthalmus Fingerling

Field: Agricultural and Biological Sciences (Life Sciences)

Background: A 90-day experiment was conducted to study the impact of salinity on growth and physiological response of Pangasionodon hypophthalmus fingerling at the Brackish water fish farm of Central Institute of Fisheries Education (CIFE), Kakinada Centre, Kakinada, East Godavari District, Andhra Pradesh, India. Method: The study used different salinities condition such as 0 (control), 5 (T1), 10 (T2) and 15 (T3) ppt. Fingerlings (8.47±0.46 g) were gradually acclimatized to different salinities in 1000 l fibre reinforced plastic (FRP) tanks, in triplicates and fed with a commercial feed (crude protein 30%). Result: Growth indicators such as specific growth rate (SGR), feed conversion ratio (FCR), feed efficiency ratio (FRR) and protein efficiency ratio (PER) revealed that growth and survival were negatively affected above 10 ppt salinity. Significantly higher amylase and protease activities were observed up to 10 ppt group. In contrast, significantly higher cortisol (97.71±1.94 ng/ml) and glucose (113.32±2.66 mg/dl) levels in the blood were recorded in 15 ppt group. Overall, the study proved that P. hypophthalmus can be cultured in low saline water (up to 10 ppt) without affecting its growth and physiological homeostasis.
The effectiveness of the organization and specific prevention of Rh-conflict during pregnancy

Field: Medicine (Health Sciences)

AIM: The aim of the study was to evaluate the effectiveness of the organization and medical provision of complex specific antenatal and postpartum prevention of primary isoimmunization with domestic anti-Rh0(D) immunoglobulin in Rh-negative women. MATERIALS AND METHODS: To achieve the goal, an algorithm for managing pregnancy in Rh-negative women was developed, complex antenatal and postpartum prophylaxis of primary isoimmunization with anti-Rh0(D) immunoglobulin was carried out, and its effectiveness was evaluated in 37 women who gave birth to Rh-positive newborns. If antibodies to the Rh0(D) antigen were not detected, then at 28 weeks pregnant women were administered human immunoglobulin anti-Rh0(D) at a dose of 1500 IU (300 g). Anti-Rh0(D) antibody titer was monitored every 23 weeks before delivery. Mothers were re-introduced with human anti-Rh0(D) immunoglobulin at a dose of 1500 IU (300 g) within 2472 hours after the birth of an Rh-positive child. 6 months after delivery, the antibody titer to the Rh0(D) antigen was re-determined. RESULTS: After the introduction of domestic human immunoglobulin anti-Rh0(D), side effects and allergic reactions were not registered. All 37 (100%) women were delivered at term, of which 7 (18.9%) were delivered abdominally. All newborns were born with an Apgar score of 89 without hemolytic disease. The titer of antibodies to the Rh0(D) antigen was negative in 24 (64.9%) women 6 months after delivery. 13 (35.1%) mothers had a post-vaccination antibody titer not higher than 1 : 2, which is allowed by the instructions for the anti-Rh0(D) human immunoglobulin preparation. They tested negative again 12 months after delivery. CONCLUSION: The results of the study showed a rather high efficiency of the organization and medical provision of complex specific antenatal and postpartum prevention of primary isoimmunization with domestic anti-Rh0(D) immunoglobulin in Rh-negative women.
Southern Solutions for Wisconsin Woes

Field: Social Sciences (Social Sciences)

Since 2011, a number of states have amended their collective bargaining laws covering state and local government employees. Debate rages about whether the goal of the proponents of change was to address budget shortfalls or weaken labor unions. Regardless of motive, legislatures in several states accomplished the goal of severely limiting or eliminating collective bargaining for some or all employees. The question facing unions, employers and employees in those states is �what now?� An answer may lie in looking to southern states like Virginia and North Carolina that have historically prohibited or severely restricted bargaining. This article explores the lessons that that might lie in the labor relations climates there for parties in states facing new and unfamiliar landscapes.The article first discusses labor relations in the southern states, with a primary emphasis on Virginia, and analyzes the factors that contribute to successful union-management relations where they exist. Then, the article considers how these factors might apply in states with newly enacted changes to their collective bargaining laws, focusing specifically on those states that eliminated or virtually eliminated bargaining rights. The article concludes that while labor relations might change in those states, unionization will survive as employees continue to seek a voice in the workplace.
The Canonical Wnt Pathway as a Key Regulator in Liver Development, Differentiation and Homeostatic Renewal

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The canonical Wnt (Wnt/β-catenin) signalling pathway is highly conserved and plays a critical role in regulating cellular processes both during development and in adult tissue homeostasis. The Wnt/β-catenin signalling pathway is vital for correct body patterning and is involved in fate specification of the gut tube, the primitive precursor of liver. In adults, the Wnt/β-catenin pathway is increasingly recognised as an important regulator of metabolic zonation, homeostatic renewal and regeneration in response to injury throughout the liver. Herein, we review recent developments relating to the key role of the pathway in the patterning and fate specification of the liver, in the directed differentiation of pluripotent stem cells into hepatocytes and in governing proliferation and zonation in the adult liver. We pay particular attention to recent contributions to the controversy surrounding homeostatic renewal and proliferation in response to injury. Furthermore, we discuss how crosstalk between the Wnt/β-catenin and Hedgehog (Hh) and hypoxia inducible factor (HIF) pathways works to maintain liver homeostasis. Advancing our understanding of this pathway will benefit our ability to model disease, screen drugs and generate tissue and organ replacements for regenerative medicine.