jimnoneill/paper-to-field-training huggingface dataset:
Effect of eugenol inhalation on the depression-like behaviors in mice and the possible underlying mechanism

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

目的 研究挥发性的芳香物质-丁香酚(Eugenol,EG)对抑郁症模型小鼠抑郁样行为的影响,评价其对抑郁症的干预作用,并探讨其可能的作用机制.方法 将30只C57BL/6雌性小鼠,采用慢性不可预见性中等强度应激(CUMS)结合孤养建立小鼠抑郁症模型.将筛选后的模型小鼠随机分为EG吸入组、盐酸氟西汀组和空白组,给予相应处理5周.并评价小鼠的行为学变化.对抑郁行为缓解后的小鼠,记录EG在不同脑区诱发的嗅觉事件相关电位(OERP),以探索其可能的作用机制.结果 ①与干预前相比:EG吸入治疗组4周后悬尾实验差异有统计学意义(P＜0.05),5周时强迫游泳实验(P＜0.05)和24 h糖水消耗量(P＜0.01)差异也有统计学意义;盐酸氟西汀组小鼠在治疗2周后强迫游泳实验差异有统计学意义(P＜0.05),3周后悬尾实验(P＜0.05)和24 h糖水消耗量(P＜0.01)差异也有统计学意义;空白组在5周后虽然糖水消耗量显著增加(P＜0.01),但是强迫游泳实验和悬尾实验差异无统计学意义(P＞0.05).②组间比较显示:EG吸入组缓解后(干预5周后)的抑郁样行为与盐酸氟西汀组缓解后(干预3周后)相比差异无统计学意义(P＞0.05).③嗅觉事件相关电位显示:在嗅球、下丘脑、海马、杏仁核等部位可以快速地记录到EG所诱发的特征性生物电变化.结论 EG的芳香疗法能够缓解抑郁症小鼠的抑郁样行为.其机制可能是通过嗅觉通路及其相关环路调节脑的情绪反应功能而起作用.
Growth response of Kampung and Pelung cross chickens to diet differed in protein content

Field: Agricultural and Biological Sciences (Life Sciences)

Two lines of native chicken (Kampung and Pelung cross) were subjected to diets differed in protein content (21, 19, 17and 15%), but isocaloric (2,900 kcal ME/kg). Ten (5 males, 5 females) day old chicks were allocated as replicate and thetreatments were 2 lines x 4 levels dietary protein. The trial was conducted for 12 weeks period . Bodyweight gain of Kampungchicken (704 g/bird) was lower than ofPelung cross chicken (844 g/bird). Based on bodyweight gain and feed conversion ratio,the optimum level of dietary crude protein was 19% for both lines, whilst consumption was not affected either by lines nor bydietary protein. Pelung cross chicken converted feed to body weight more efficiently than Kampung chicken did. However feedconversion ratio increased with decreasing in dietary protein. Mortality was not affected either by lines nor by dietary protein.Twelve weeks carcass percentage of Pelung cross (64,9%) was higher than of Kampung chickens (62,9%), however carcass percentage was not affected by the dietary protein. Abdominal fat pad was not affected by lines of chickens nor dietary protein. Â Key words : Native chicken, protein, growth, carcass
Analysis of Maize Commercialization Among Smallholder Farmers: In the Case of Gog Districts, Anywaa Zone, Ethiopia

Field: Agricultural and Biological Sciences (Life Sciences)

Agricultural commercialization is a process of transformation from subsistence farming system to market oriented production system. Motivating smallholder farmers to produce further than their consumption and empowering them to be profit oriented should be given priority in order to foster the economic growth in developing countries where agriculture is the pillar of the economy and smallholder farmers are the largest section of the country like Ethiopia. Nevertheless, due to a number of reasons smallholder farmers’ level of commercialization is very low and insignificant. There are only few studies conducted about agricultural commercialization in Ethiopia but the studies are not focused to the study area. Consequently, the aimed to analyze the factors that determine market participation and degree of commercialization by smallholder maize producers in Gog district, Anywaa Zone, Ethiopia. Data were collected from 385 smallholder maize producers in three districts where maize is produced potentially through multistage sampling method. Furthermore, interview schedule, focus group discussion and key informant interview were used to gather the required primary data. In order to attain the study aims, Tobit model was employed to analyses both market participation and intensity of commercialization. From the analysis education level, livestock holding, frequency of extension contact, training, off/non-farm income activity, quantity of maize and lagged price were found to have significant effect on market participation while intensity of commercialization was significantly influenced by education level, livestock holding, training, frequency of extension contact, off/non-farm activity, quantity of maize produced and lagged price. To conclude based on the results, smallholder maize producers should be supported frequently by extension agents in order to upsurge their practical skills which results enhancement of their market participation and intensity of commercialization. Keywords: Gog, Commercialization, Maize, Smallholder producers, Tobit model DOI: 10.7176/JESD/12-21-03 Publication date: November 30 th 2021
The effect of atorvastatin on the expression of Krüppel-like factor 2 in apolipoprotein E gene knockout mice

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Objective To explore the effect of atorvastatin on the expression of Kruppel-like factor 2 in apolipoprotein E (ApoE) gene knockout mice. Methods ApoE gene knockout (ApoE-/-) mice were randomized into intervention group and control group. Atorvastatin [10 mg/(kg·d)] was applied as the interventional drug. After 8 weeks of intervention, KLF2 gene and its protein expression were measured by semiquantitative real-time PCR, immunohistochemistry, and Western blot. HE staining was used to caculat the relative area of palque. Results The expression of KLF2 in intervention group was higher than control group on different levels [mRNA (0.85±0.01) vs (0.48±0.02), protein (1.84±0.11) vs (1.45±0.14) and histology (0.40±0.06) vs (0.26±0.09), all P0.05], and the relative plague area of intervention group was significantly less than that of control group [(0.26±0.09) vs (0.41±0.04), P0.01]. Conclusion Atorvastatin can up-regulat KLF2 in aorta of ApoE-/- mice.
The comparison of glucose and lipid metabolism parameters in drug-naïve, antipsychotic-treated, and antipsychotic discontinuation patients with schizophrenia

Field: Medicine (Health Sciences)

Xiaoli Wu,1,2 Zeping Huang,3 Hongying Han,2 Zhiyong Zhong,2 Zhaoyu Gan,2 Xiaofeng Guo,1 Feici Diao,2 Zili Han,2 Jingping Zhao1 1Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, People’s Republic of China; 2Psychiatry Department, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 3Ultrasound Department, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China Background: Although many studies have reported that glucose and lipid metabolism disorders are a significant side effect associated with the use of antipsychotic drugs, the characteristics of glucose and lipid metabolism disorders in patients with schizophrenia who are taking antipsychotic drugs remain poorly understood, and the possible effects that antipsychotic discontinuation may have on glucose and lipid metabolism remain unclear. Methods: The sample consisted of 131 Chinese patients with schizophrenia, including 70 first-episode, drug-naïve patients; 33 patients who had received continuous antipsychotic drug treatment for ≥1 year prior to the beginning of the study; and 28 patients who had discontinued antipsychotic drug treatment for ≥3 months prior to the beginning of study. We compared the glucose and lipid metabolic parameter levels among the three groups of patients with schizophrenia. All assessments were performed upon hospital admission. Results: The characteristics of glucose and lipid metabolism disorders in Chinese patients with schizophrenia who are taking antipsychotic drugs included significant augmentation of the body mass index and waist circumference, significantly higher levels of fasting plasma insulin and insulin resistance, and significantly lower plasma high-density lipoprotein cholesterol levels. Antipsychotic discontinuation appeared to not significantly improve any plasma glucose and lipid metabolic parameter levels. Conclusion: The results suggest that antipsychotic drugs aggravate glucose and lipid metabolism disorders and that antipsychotic discontinuation is generally not associated with improvements in the parameters that indicate glucose and lipid metabolism disorders in Chinese patients with schizophrenia. Keywords: antipsychotic-treated, antipsychotic discontinuation, drug-naïve, glucose, lipid, schizophrenia
Scrofimicrobium appendicitidis sp. nov., isolated from a patient with ruptured appendicitis

Field: Immunology and Microbiology (Life Sciences)

A clinical isolate, R131, was isolated from the peritoneal swab of a patient who suffered from ruptured appendicitis with abscess and gangrene in Hong Kong in 2018. Cells are facultatively anaerobic, non-motile, Gram-positive coccobacilli. Colonies were small, grey, semi-translucent, low convex and alpha-haemolytic. The bacterium grew on blood agar but not on Brain Heart Infusion (BHI) and Mueller–Hinton agars. It was negative for catalase, oxidase, indole and aesculin hydrolysis. The initial identification attempts via matrix-assisted laser desorption ionization–time of flight mass spectrometry and 16S rRNA gene sequencing yielded inconclusive results. The 16S rRNA gene analysis showed that R131 shared >99% nucleotide identity with certain uncultured Actinomycetales bacteria. In this retrospective investigation, a complete genome of R131 was constructed, disclosing a DNA G+C content of 64%. Phylogenetic analysis showed that the bacterium was mostly related to Scrofimicrobium canadense WB03_NA08, which was first described in 2020. However, its 16S rRNA gene shared only 94.15% nucleotide identity with that of S. canadense WB03_NA08. Notably, the orthoANI between R131 and S. canadense WB03_NA08 was 67.81%. A pan-genome analysis encompassing R131 and 4 Scrofimicrobium genomes showed 986 core gene clusters shared with the Scrofimicrobium species, along with 601 cloud genes. The average nucleotide identity comparisons within the pan-genome analysis ranged from 59.78 to 62.51% between R131 and the other Scrofimicrobium species. Correspondingly, the dDDH values ranged from 19.20 to 22.30%, while the POCP values spanned from 57.48 to 60.94%. Therefore, a novel species, Scrofimicrobium appendicitidis sp. nov., is proposed. The type strain is R131 T (=JCM 36615 T =LMG 33627 T ).
Issue Publication Information

Field: Materials Science (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleIssue Publication InformationCite this: ACS Appl. Mater. Interfaces 2020, 12, 31, XXX-XXXPublication Date (Web):August 5, 2020Publication History Published online5 August 2020Published inissue 5 August 2020https://doi.org/10.1021/amv012i031_1400291Copyright © 2020 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views71Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (175 KB) Get e-Alerts Get e-Alerts
Latitudinal variation of maximum observed United States rainfall east of the Rocky Mountains

Field: Earth and Planetary Sciences (Physical Sciences)

Investigation of the latitudinal variation of observed rainfall magnitudes for specific areas and durations in over 300 major storms reveals a remarkably consistent latitudinal location of the peak magnitudes at about 30°–31°N, abrupt declines south of the peaks and uniform variations to the north. The effect on these variations of relative opportunities for rainfall measurement and major‐storm occurrence is discussed and possible dynamic causes for the observed variations are briefly outlined.
Detection of serum leptin levels in patients with viral hepatitis C

Field: Medicine (Health Sciences)

To evaluate changes of serum leptin levels in patients with viral hepatitis C(HCV),serum leptin levels were determined by RIA in 65 patients with viral chronic hepatitis C and in 80 control subjects,liver function(ALT,AST),glucose(Glu),and total cholesterol(TC) were evaluated too.Campared with controls,the levels of serum leptin were significantly increased in patients with HCV(P0.01).Serum leptin levels had remarkable positive correlations with ALT and AST(P0.05),but not with Glu and TC(P0.05).The levels of serum leptin increased in patients with HCV,which correlates positively with the severity of liver inflammation,so that leptin can be regarded as an index which reflects the severity of liver inflammation.
Hypertension prediction and analysis of risk factors based on physical examination report data

Field: Medicine (Health Sciences)

Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. This paper presents a method to predict hypertension using Deep Neural Network(DNN) by physical examination report dataset, and compares the performance of DNN with the ensemble learning algorithm based on decision trees. The results indicate that the DNN demonstrates distinct advantages across various evaluation metrics, achieving an accuracy rate of 89.54%, a precision rate of 87.89%, a recall rate of 91.85% and the f1 score is 89.82%. Subsequently, Random Forest(RF) algorithm is selected to analyze the risk factors from the physical examination reports. The findings reveal that age, weight, triglyceride(TG), glutamic oxaloacetic transaminase(GOT), gamma-glutamyl transpeptidase(GGT), basophil(BASO), ca199, Glycated hemoglobin HbA1c(HbA1c), RBC average distribution width(RDW), Alanine aminotransferase(ALT) are among the top 10 risk factors for hypertension.
Epitaxial growth and electronic structure of Au films of fcc (111) metals studied by electron reflection spectroscopy

Field: Physics and Astronomy (Physical Sciences)

The reflection coefficient for low-energy electrons on clean fcc (111) metal surfaces shows details determined by the electronic potential in the first few surface layers. This is used to monitor the epitaxial growth of Au overlay films on Pd, Ag, and Ni substrates. On Pd, the lattice constant of the initial Au layers contracts to conform to the Pd but after about three layers assumes the value for bulk Au. Observed shifts of the Au peaks are consistent with predictions of band theory. For Ag and Ni substrates the first few Au layers grow with the bulk lattice constant. The decrease of substrate peak intensity with thickness is consistent with layer-by-layer growth for all three substrate metals. On Pd, thicker Au films show quantum size-effect oscillations at low energies, implying film-thickness uniformity on an atomic scale. These results are compared with those of other techniques. We conclude that electron reflection is a sensitive and relatively simple way of monitoring the growth stages of epitaxial layers.
Analysis of Terpene Constituents in White P. nigrum L.

Field: Agricultural and Biological Sciences (Life Sciences)

The water distillation-extractor was used for extracting the volatile substances of white P. nigrum L.in Hainan. Theaverage oil yield obtained was 4.7 % . 35 components were identified by GC / MS method. The contents of the identifiedterpinene compounds make up 88.70% of the total volatile substances detected.
The Association Between Serum Human Epididymis Protein 4 Level and Cardiovascular Events in Patients with Chronic Obstructive Pulmonary Disease

Field: Medicine (Health Sciences)

Abstract Objective Serum human epididymis protein 4 (HE4) is associated with immune and inflammatory responses. This study aimed to assess the performance of serum HE4 in the early detection of cardiovascular (CV) events in patients with chronic obstructive pulmonary disease (COPD). Methods Serum HE4 levels were measured in 199 patients with COPD, all of whom were prospectively followed up for a median period of 36 months (range = 3 months–38 months). Logistic regression analysis was performed to assess the association between cardiovascular disease (CVD) history and HE4 in patients with COPD. Cox proportional hazard analysis was performed to assess the prognostic value of serum HE4 for predicting CV events. Results Serum HE4 levels were higher in patients with COPD with CV events than in those without CV events (252.6 pmol/L [186.4–366.8] vs 111.0 pmol/L [84.8–157.1]; P &lt;.001). The multivariate logistic regression model revealed that serum HE4 (odds ratio = 1.639; 95% confidence interval [CI], 1.213–2.317; Ptrend =.009) was independently associated with CVD history after adjusting for age, sex, body mass index, current smoking status, current alcohol consumption status, admission systolic blood pressure and diastolic blood pressure, hyperlipidemia, left ventricular ejection fraction, primary diseases, and laboratory measurements in patients with COPD at baseline. The multivariate Cox proportional hazard analysis revealed that serum HE4 (hazard ratio = 2.012; 95% CI, 1.773–4.469; P &lt;.001) was an independent prognostic factor for CV events in these patients. The Kaplan-Meier analysis showed that the rate of CV events was higher in patients with COPD with HE4 levels above the median (187.5 pmol/L) than in those with HE4 levels below the median. Conclusion Our results showed that serum HE4 was significantly and independently associated with CVD history and had independent predictive value for CV events in patients with COPD. Serum HE4 may enable early recognition of CV complication development among patients with COPD.
A re‐evaluation of the phylogenetic relationships in the Apidae (Hymenoptera)

Field: Agricultural and Biological Sciences (Life Sciences)

ABSTRACT . The relationships between the four tribes in the bee family Apidae are re‐examined. Characteristics of the postgena, presternum, antenna cleaner, arolium, female hind tibia and male genitalia, among others, support the placement of these tribes in three subfamilies: Meliponinae (Meliponini), Apinae (Apini) and Bombinae (Euglossini + Bombini). The Apinae is the sister group of the Bombinae. This tribal arrangement was originally proposed, using different characteristics, by Winston & Michener (1977).
Guest Editorial: Proceedings of the Boston Symposium on Food Rheology, October 17–21, 1993

Field: Chemical Engineering (Physical Sciences)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Jozef L. Kokini; Guest Editorial: Proceedings of the Boston Symposium on Food Rheology, October 17–21, 1993. Journal of Rheology 1 November 1995; 39 (6): 1427. https://doi.org/10.1122/1.550644 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
A Complement–IL-4 Regulatory Circuit Controls Liver Regeneration

Field: Medicine (Health Sciences)

Abstract The involvement of IL-4 in liver regeneration has not yet been recognized. In this article, we show that IL-4, produced by NKT cells that accumulate in regenerating livers after partial hepatectomy, contributes to this process by regulating the activation of complement after liver resection in mice. The mechanism of this regulation was associated with the maintenance of an appropriate level of IgM in mouse blood, because IgM deposited in liver parenchyma most likely initiated complement activation during liver regeneration. By controlling complement activation, IL-4 regulated the induction of IL-6, thereby influencing a key pathway involved in regenerating liver cell proliferation and survival. Furthermore, the secretion of IL-4 was controlled by complement through the recruitment of NKT cells to regenerating livers. Our study thus reveals the existence of a regulatory feedback mechanism involving complement and IL-4 that controls liver regeneration.
Crystallographic Characterization of the Molecular Structure and Solid State Packing of the Fullerene-Shaped Hydrocarbon C36H12

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTCrystallographic Characterization of the Molecular Structure and Solid State Packing of the Fullerene-Shaped Hydrocarbon C36H12David M. Forkey, Saeed Attar, Bruce C. Noll, Richard Koerner, Marilyn M. Olmstead, and Alan L. BalchView Author Information Department of Chemistry, University of California Davis, California 95616 Cite this: J. Am. Chem. Soc. 1997, 119, 24, 5766–5767Publication Date (Web):June 18, 1997Publication History Received17 March 1997Published online18 June 1997Published inissue 1 June 1997https://pubs.acs.org/doi/10.1021/ja970845jhttps://doi.org/10.1021/ja970845jrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views600Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Carbon nanomaterials,Hydrocarbons,Molecules,Nanospheres,Supramolecular chemistry Get e-Alerts
Sparse SAR Imaging Based on Non-Local Asymmetric Pixel-Shuffle Blind Spot Network

Field: Computer Science (Physical Sciences)

The integration of Synthetic Aperture Radar (SAR) imaging technology with deep neural networks has experienced significant advancements in recent years. Yet, the scarcity of high-quality samples and the difficulty of extracting prior information from SAR data have experienced limited progress in this domain. This study introduces an innovative sparse SAR imaging approach using a self-supervised non-local asymmetric pixel-shuffle blind spot network. This strategy enables the network to be trained without labeled samples, thus solving the problem of the scarcity of high-quality samples. Through asymmetric pixel-shuffle downsampling (AP) operation, the spatial correlation between pixels is broken so that the blind spot network can adapt to the actual scene. The network also incorporates a non-local module (NLM) into its blind spot architecture, enhancing its capability to analyze a broader range of information and extract more comprehensive prior knowledge from SAR data. Subsequently, Plug and Play (PnP) technology is used to integrate the trained network into the sparse SAR imaging model to solve the regularization term problem. The optimization of the inverse problem is achieved through the Alternating Direction Method of Multipliers (ADMM) algorithm. The experimental results of the unlabeled samples demonstrate that our method significantly outperforms traditional techniques in reconstructing images across various regions.