jimnoneill/paper-to-field-training huggingface dataset:
Use of RET inhibitors among patients with advanced NSCLC: A real-world evidence analysis.

Field: Medicine (Health Sciences)

9079 Background: RET rearrangements are found in approximately 1% to 2% of patients with NSCLC. Two selective RET inhibitors have been FDA approved based on phase 1/2 data showing significant activity among patients with advanced NSCLC that have RETrearrangements. The objective of this retrospective analysis was to look at the prognostic outcome associated with the use of selective RET inhibitors (sRETi) and multikinase inhibitors (MKIs) that have been used to target RET fusions among pts with NSCLC in the real-world setting. Methods: We utilized a federated network of de-identified health data representing approximately 84 million pt lives available through the TriNetX Research Network. We identified 1,215 pts with metastatic NSCLC treated with selpercatinib, praseltinib, cabozantanib or vandetanib. Overall survival (OS) was evaluated with Kaplan Meier statistics and compared between patients treated with either sRETi (selpercatinib or pralsetinib) vs either MKI (cabozantanib or vandetanib). Results: Mean age among all anti-RET treated patients was 67.6 years. 518 pts (43%) were female and 697 (57%) were male. 531 (39.6%), 205 (15.3%) and 605 (45.1%) pts had received selpercatinib, pralsetinib, and either cabozantinib or vandetinib, respectively. 56.6% of pts receiving pralsetinib received prior selpercatinib. Among pts receiving sRETi, 39.7%, 6.4%, 11.2%, and 32.4% received sRETi in the 0-3, 3-6, 6-12, and 12+ months after metastatic diagnosis, respectively. Among pts receiving MKIs, 17.0%, 8.4%, 13.3%, and 44.9% received MKIs in the 0-3, 3-6, 6-12, and 12+ months after metastatic diagnosis. Median OS after treatment with MKIs and sRETi during any time frame was 16.3m and 25.0m, respectively (p < 0.01). Among pts treated with MKIs vs sRETi during the 0-3, 3-6, 6-12, and 12+ months after metastatic diagnosis, 1-year survival probability after treatment was 59.7% vs 55.9% (p = 0.39), 45.0% vs 83.1% (p < 0.01), 53.9% vs 82.2% (p < 0.01), and 57.7% vs 87.1% (p < 0.01), respectively. 30% of pts of all anti-RET treated patients had brain metastases, and median OS from index metastasis among pts with and without brain metastases was 31.4m and 63.1m respectively (p < 0.01). Conclusions: To our knowledge this is the first real world data set to show a > 8m improvement in OS with the use of sRETi compared to MKIs among pts with metastatic NSCLC. OS improvements may be more significant in pts treated in later lines of therapy with sRETi.
Consumer Tribe dan Industri Gaya Hidup di Bandung, Indonesia

Field: Social Sciences (Social Sciences)

Abstract\n\nIn 2015, UNESCO rewarded Bandung as one of World’s Creative City for ‘design’ category. This raised many reactions from the public, including ones questioning the emergence and existence of communities who plays the main role in the creative industry of the city. One of the most significant role comes from the youth culture in the city who produces goods as part of their life styles that has become economically successful and is claimed to be the actors of creative industry in Bandung, and in Indonesia in a bigger scheme. The fact is, many of these companies emmerge from the diffusion of globalization into the youth culture where at some point create the need to reproduce its cultural icons and symbols into items with more reasonable pricing. The youth culture and its life styles then construct a mutual relation, between producers and consumers, to support this act of reproduction which is unique because it involves sharing of idealisms. With a perspective of consumers tribe, this article tries to unfold the historical journey of Bandung’s youth culture and relates it with the social process that occurs within its economic significance.\n\nKeywords: Culture, Life Styles, Globalization and economic\n\n \n\nAbstrak\n\nPada tahun 2015, UNESCO menobatkan Bandung sebagai salah satu kota kreatif dunia, atau World’s Creative City, dalam kategori desain. Hal ini mengundang banyak reaksi publik, termasuk mereka yang mempertanyakan kemunculan dan eksistensi komunitas-komunitas yang memiliki peran utama dalam industri kreatif kota tersebut. Salah satu peran signifikan dipegang oleh budaya anak muda perkotaan yang memproduksi barang sebagai bagian dari gaya hidup mereka yang menjadi sukses secara ekonomi dan diklaim sebagai aktor industri kreatif baik di Bandung maupun di Indonesia. Faktanya, banyak dari perusahaan ini muncul dari difusi globalisasi dalam budaya anak muda sampai pada satu titik dimana anak muda memiliki kebutuhan untuk meniru ikon dan simbol kultural menjadi barang dengan harga yang lebih terjangkau. Budaya anak muda dan gaya hidup mereka kemudian membentuk hubungan timbal balik antara produsen dan konsumen untuk mendukung aksi meniru yang unik ini, karena melibatkan pertukaran idealisme. Dengan perspektif kaum konsumen, artikel ini membuka perjalanan historis budaya anak muda Bandung dan menghubungkannya dengan proses sosial yang terjadi dalam makna ekonominya.\n\nKata Kunci: Budaya, Gaya Hidup, Globalsasi dan Ekonomi
Rings of power

Field: Arts and Humanities (Social Sciences)

This chapter considers how personal ornaments were deployed in the ‘broad-sense’ politics of power struggles between and within aristocratic groups. Jewellery and clothing were convenient movable goods which could be displayed to express one’s wealth in a day-to-day context, outside the more highly charged ceremonies of early medieval social life such as betrothal, marriage and burial, all while playing an important role in these, too. In France, interpreting objects from the early Middle Ages has been based on an ideal, modern image of personal belongings, the legacy of an otherwise superseded historiography of ‘fine objects.’ Textual sources do indeed demonstrate the importance of gold, silver and gems, all of which were highly prized for their prestige in early medieval societies. Copper alloy items are often described as copies, imitations or else as having been produced for individuals of lesser status. Byzantine betrothal rings, from the Roman Catholic tradition, are a telling example of what can be analysed from this perspective.
Comparing Ambient Temperature Effects on Heat Pulse and Time Domain Reflectometry Soil Water Content Measurements

Field: Environmental Science (Physical Sciences)

Time domain reflectometry (TDR) and the heat pulse method are both used to measure soil water content. Changes in ambient temperature have been shown to affect TDR measurements, but less is known about the behavior of heat pulse sensors in response to changes in temperature. This study directly measured and compared the temperature sensitivity of the TDR and heat pulse methods. Both methods were used to estimate water content in silt loam and sand at two fixed water contents across a wide temperature range. An increase in temperature led to an increase in measured water content in most cases. Across the 40°C temperature range, changes in measured water content were generally 0.04 m 3 m −3 or less for both methods. Weighted linear regression showed that in these soils the heat pulse method exhibited greater temperature sensitivity than the TDR method, although the differences were not statistically significant. A previously proposed correction for the temperature sensitivity of the TDR method produced mixed results. The temperature sensitivity of the heat pulse method was attributed to the changes in the density and specific heat of water and specific heat of soil with respect to temperature. When the changes in these parameters were accounted for, the temperature sensitivity was eliminated in three out of four cases.
Mecca’s Cult and Medina’s Constitution in the Qurʾān: A New Reading of al-Māʾidah

Field: Arts and Humanities (Social Sciences)

Abstract The Qurʾān’s fifth sura denounces the killing of game during pilgrimage and decries the killing of innocent Believers. This juxtaposition reflects the intimate connection between right worship and proper social order, between cult and covenant, a connection that animates the entire sura . In particular, the sura suggests that if Jews and Christians have been generally unreliable allies, if they have been often reluctant to support the Believers’ military efforts against the Quraysh, and if they were even unwilling to requite violence against innocent Believers, it was because the People of the Book mostly had a negative view of the Meccan Sanctuary and its rituals. Specifically, they derided the central rite of ṣalāt , which may have been accompanied with sacrifices on certain occasions (such as Fridays). In the light of their opposition to the Meccan cult, the sura commands the Believers not to take Jews or Christians as covenantal partners. It is possible that the sura thereby ended the Believers’ alliance with some Jewish tribes of Yathrib as enshrined in the Constitution of Medina. What supports this possibility is that al-Māʾidah has significant thematic and terminological overlaps with the Constitution of Medina, as alliance with the Jews and deterring violent crimes through retaliation are central concerns to both documents. Still, and contrary to the interpretations of several scholars, it is doubtful that at the time of al-Māʾidah ’s proclamation the Prophet had judicial authority over the People of the Book or that he sought to impose violent punishment against them.
Formulation and Evaluation of Tablets Using the Solvent Evaporation Method to Increase the Solubility of Lansoprazole

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The inability to determine sufficient and repeatable bioavailability and/or desirable pharmacokinetic features in humans is one of the biggest obstacles to the oral administration of new medicines. The solubility and absorption of a medicine determine its bioavailability, which in turn determines its therapeutic efficacy. Achieving the target drug concentration in the systemic circulation and ensuring drug biological activity in humans are both affected by solubility. A stomach ulcer has the potential to rip through the stomach lining, the initial section of the small intestine, and possibly even the lower esophagus. Distinct ulcers form in different parts of the intestines; one forms in the duodenum and one in the stomach. Duodenal ulcers are most commonly characterized by upper abdominal pain at night that subsides after eating. Eating might exacerbate the discomfort from a stomach ulcer. Preparing and assessing the pills will yield optimal outcomes. The active component content is 99.90%, as is the active ingredient release rate. Compared to other formulations, solid dispersion tablets performed better in in-vitro tests (98.85%). The optimized formulation (lansoprazole solid dispersion tablets) outperformed the labeled formulation (conventional lansoprazole tablet) in terms of drug-releasing capacity within 6 hours, outperforming both formulations.
1908-P: Factors Related to Hepatic Fat and Fibrosis in American Indians

Field: Medicine (Health Sciences)

American Indians (AI) experience high rates of both liver disease and type 2 diabetes (T2D), yet few studies have investigated the contributions of T2D and other known risk factors to liver disease in AI. We used magnetic resonance imaging (MRI)-estimated proton density fat fraction (PDFF) and MR elastography (MRE)-estimated stiffness to assess hepatic fat and fibrosis, respectively, and assessed whether obesity, T2D, and heavy episodic alcohol (ETOH) consumption are associated with these liver measures in AI. The Strong Heart Family Study (SHFS) is a population-based family study of AI recruited from 12 communities located within Arizona (AZ), the Dakotas, and Oklahoma (OK). Metabolic measures were assessed during a clinic visit in 2006-2009. A re-exam including MRI and MRE has been conducted on 109 participants to date from AZ and OK (mean age 50.6 ± 11.3 years, 72% women, 71% obese (BMI ≥ 30 kg/m2), 57% had T2D, and 28% reported ETOH consumption). Median liver PDFF was 8.9% (1rst and 3rd quartiles: 4.3%, 14.6%), with 71% of participants having elevated liver fat (PDFF ≥ 5%). Median liver stiffness was 2.6 kPa, with 23% showing mild liver fibrosis (stiffness 2.8 - 3.63 kPa) and 8.3% advanced liver fibrosis (stiffness &gt; 3.63 kPa). In cross-sectional analyses, liver PDFF was significantly higher in obese vs. non-obese participants (Wilcoxon rank sum test, p&lt;0.0001). In longitudinal analyses using a generalized linear model, after adjusting for age, sex, and study site, obesity measures (waist p=0.005; BMI p=0.01), HbA1c (p=0.001), liver enzyme levels (ALT p=0.03) and serum uric acid (p=0.0002) were associated with elevated PDFF. Obesity (waist p=0.001; BMI p=0.02) and cigarette smoking (p=0.002) were associated with elevated liver stiffness. In our at-risk subsample of AI participants of the SHFS, participants commonly had elevated liver fat and liver fibrosis, with obesity being the major, common, associated risk factor. Disclosure S.A. Cole: None. W.C. Henderson: None. T. Ali: None. C. West: None. M.S. Middleton: Consultant; Self; Kowa Pharmaceutical Europe Co. Ltd., Median, Novo Nordisk Inc. Stock/Shareholder; Self; General Electric, Pfizer Inc. A. Silva: None. D.N. Batakis: None. A.L. Louie: None. B.V. Howard: None. J.D. Dvorak: None. R. Devereux: Consultant; Self; Acer. J.G. Umans: None. C. Sirlin: Advisory Panel; Self; AMRA Medical, Bristol-Myers Squibb Company, VirtualScopics. Consultant; Self; Fulcrum Therapeutics. Other Relationship; Self; Celgene Corporation, Enanta Pharmaceuticals, Inc., Genzyme, Gilead Sciences, Inc., Gilead Sciences, Inc., ICON plc., Intercept Pharmaceuticals, Inc., Janssen Pharmaceuticals, Inc., NuSirt Biopharma, Inc., Shire, Synageva, Takeda Pharmaceutical Company Limited, VirtualScopics. Y. Zhang: None. Funding National Institute of Diabetes and Digestive and Kidney Diseases (R01DK110096)
Data from Prospective Evaluation of Cetuximab-Mediated Antibody-Dependent Cell Cytotoxicity in Metastatic Colorectal Cancer Patients Predicts Treatment Efficacy

Field: Medicine (Health Sciences)

<div>Abstract<p>Cetuximab is a monoclonal antibody to the EGFR that induces antibody-dependent cell cytotoxicity (ADCC) through Fcγ receptors on immune cells. Although SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer, a direct correlation between <i>in vitro</i> ADCC and clinical response to cetuximab is not defined. We therefore enrolled 96 consecutive metastatic colorectal cancer (mCRC) patients at diagnosis in a study that assessed FcγR status and cetuximab-mediated ADCC. Patients carrying the FcγRIIa <i>H</i> alleles 131<i>H/H</i> and 131<i>H/R</i> had significantly higher ADCC compared with patients with the 131<i>R/R</i> alleles (<i>P</i> = 0.013). Patients carrying FcγRIIIa genotypes with the <i>V</i> alleles 158<i>V/V</i> and 158<i>V/F</i> displayed higher ADCC compared with patients carrying the 158<i>F/F</i> genotype (<i>P</i> = 0.001). Progression-free survival of patients with an FcγRIIIa 158<i>V</i> allele was significantly longer compared with patients carrying 158<i>F/F</i> (<i>P</i> = 0.05), whereas no significant difference was observed for overall survival. Twenty-eight of 50 mCRC patients with wild-type KRAS received cetuximab. The average ADCC-mediated killing was 30% of assay targets for patients who experienced cetuximab complete or partial response, 21% in patients with stable disease and 9% in patients with progressive disease. To characterize basal natural killer (NK) activity, cytotoxicity was evaluated in 39 of 96 mCRC patients. Patients who responded to first-line treatment had higher NK-cell cytotoxicity. Thus, although limited to this cohort of patients, <i>in vitro</i> cetuximab-mediated ADCC correlated with FcγR polymorphisms and predicted cetuximab responsiveness. <i>Cancer Immunol Res; 4(4); 366–74. ©2016 AACR</i>.</p></div>
Mpox Outbreaks, Challenges of Management, Smallpox to the Rescue: A Review Article

Field: Medicine (Health Sciences)

Abstract: Mpox is a viral zoonotic disease caused by the monkeypox virus. Its incidence has risen in recent years due to the decline in immunity from previous smallpox infections and the cessation of smallpox vaccinations following its eradication. This article reviews published studies and webpages from various organizations, focusing on the history and updates of mpox outbreaks and their management. Research articles, book chapters, review articles, and other pertinent literature were gathered from online databases such as PubMed, Google Scholar, ScienceDirect, and PubMed Central. Mpox morbidity can range from mild to severe, with secondary complications that may be fatal. Several outbreaks have occurred in recent decades. The recent global outbreak of mpox, which began in May 2022, primarily affected men who have sex with men. The increase in the global spread of mpox has gained international attention and in 2024, mpox was declared a Public Health Emergency of International Concern (PHEIC) by the Africa Centre for Disease Control and Prevention (Africa CDC) and the World Health Organization (WHO). Smallpox has played a vital role in the management of mpox through research on treatments and vaccines. The eradication of smallpox provides hope for effective control of mpox, as eradicating mpox may be challenging due to the presence of nonhuman hosts. Surveillance and research are crucial in achieving this objective. Keywords: Mpox, monkeypox, history, outbreaks, vaccination, smallpox. Title: Mpox Outbreaks, Challenges of Management, Smallpox to the Rescue: A Review Article Author: Chinyerem Cynthia Nwachukwu, Ifeoma Anne Njelita, Ifeanyi Gabriel Eyisi, Amaechi Chinedu Nwachukwu, Chijioke Amara Ezenyeaku International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Vol. 13, Issue 1, April 2025 - September 2025 Page No: 24-31 Research Publish Journals Website: www.researchpublish.com Published Date: 05-April-2025 DOI: https://doi.org/10.5281/zenodo.15160053 Paper Download Link (Source) https://www.researchpublish.com/papers/mpox-outbreaks-challenges-of-management-smallpox-to-the-rescue-a-review-article
THE OCCURRENCE AND SIGNIFICANCE OF ABNORMAL BILE DUCT EPITHELIUM IN CIRRHOSIS

Field: Medicine (Health Sciences)

Revision of a biopsy series of 497 consecutive cases of cirrhosis revealed 31 with abnormal bile duct epithelium, corresponding to 7 per cent. It is rendered probable on the basis of morphological, clinical, biochemical, and immunological findings, that this group of cryptogenic cirrhosis has developed from chronic aggressive hepatitis. It has previously been shown, that chronic aggressive hepatitis with abnormal bile duct epithelium more quickly develops cirrhosis than chronic aggressive hepatitis without abnormal bile duct epithelium. Contrary to this finding cirrhosis with abnormal bile duct epithelium does not, during the rather short period of observation in our material (27 months) exhibit a course, that deviates from other cases of cirrhosis, as the death rate is not different from that of a larger material of cirrhosis.
[Bile leakage after laparoscopic cholecystectomy: report of three cases in our experience].

Field: Medicine (Health Sciences)

Laparoscopic cholecystectomy (LC) is associated with an higher incidence of bile duct injury than open cholecystectomy. There has been concern and the reason why bile leakages are more frequent with LC is yet unclear. Bile collections can occurr because of major about (75%) or minor (about 25%) injuries. Anyway, external biliary decompression is a key factor in the treatment, in order to avoid an emergency intervention. The Authors report their experience concerning 3 cases of bile leakages among a series of 458 LC. Only in one of the three cases the subhepatic space was not drained and an emergency laparotomy was performed. The Authors, on the basis of their own experience and of the data reported in literature, suggest the routinary intraoperative placement of a drainage into the subhepatic space, to be removed, if no complications occur, one day after surgery.
THE EFFECT OF E-SERVICE QUALITY AND PRICE ON CUSTOMER LOYALTY WITH CUSTOMER SATISFACTION AS MEDIATING VARIABLE (A CASE STUDY ON WEBINAR SERVICE IN INDONESIAN CLINICAL TRAINING & EDUCATION CENTER (ICTEC) RSCM FKUI)

Field: Business, Management and Accounting (Social Sciences)

During the COVID-19 pandemic, Information Technology (IT) is critically needed to support and improve ones performance in all matters, including services and day-to-day activities. This study aims to determine and analyze the effect of e-service quality and price on customer loyalty with customer satisfaction as mediating variable on webinar service in Indonesian Clinical Training & Education Center (ICTEC) RSCM FKUI. The technique of this study was purposive sampling and the questioner as the primary data instrument. The data was taken from 100 respondents that have participated in webinars with ICTEC RSCM FKUI. This study used SEM (Structural Equation Modeling) supported by SmartPLS application. The result of this study shows the variable of e-service quality and price has made a significant impact on customer satisfaction; the variable of e-service quality has an impact on customer loyalty; customer satisfaction has an significant impact on customer loyalty, yet the variable of price made insignificant on customer loyalty. In terms of moderation (intervening), the variable of e-service quality and price has made a significant impact on customer loyalty with customer satisfaction.
Corrigendum: Wavefunction in Density Functional Theory Embedding for Excited States: Which Wavefunctions, which Densities?

Field: Chemistry (Physical Sciences)

In the recently published paper entitled Wavefunction-in-Density Functional Theory Embedding for Excited States: Which Wavefunctions, which Densities?, a line is missing from Table 1, which describes the functionals used in the embedding calculations.The correct table below is reported below, with the relevant change given in boldface.This omission was introduced during production.
Predictors of coronary slow flow in stable coronary artery disease

Field: Medicine (Health Sciences)

Although several studies have shown that endothelial dysfunction and inflammation may play roles in coronary slow flow phenomenon (CSFP), its etiology and pathogenesis still unclear and based on this observation our aim was detection of clinical and laboratory predictors of primary CSFP judged by TIMI frame count in coronary angiography (CA) for stable coronary artery disease patients (SCAD). Case control study included 120 patients with SCAD who underwent CA. They were classified into two groups: PCSF group and normal coronary flow group. All patients subjected to CBC, platelet count, leucocytic count (total and differential), platelet-to lymphocyte ratio (PLR), neutrophil-to lymphocyte ratio (NLR), uric acid, albumin, Hs.CRP levels and CA with TIMI frame count. Incidence of diabetic mellitus and smoking were significantly higher in PCSF compared to control (P = 0.01), also we found PLR, NLR, uric acid and Hs-CRP levels were significantly higher in PCSF compared to control (P < 0.0001). The sensitivity of PLR ≥ 150, NLR ≥ 2, albumin level ≤ 3.5 g/dl, uric acid ≥ 6 mg/dl and Hs.CRP ≥ 6 mg/L for prediction of CSFP were (83.3%, 90.0%, 50.0%, 76.7% and 83.3% respectively) while the specificity were (86.7%, 90.0%, 53.3%, 83.3% and 86.7%) respectively. The multivariate analysis showed NLR ≥ 2 as the only independent predictor of PSCF. PCSF was common in smokers and diabetic patients and this phenomenon is associated with high PLR, NLR, Serum uric acid and Hs.CRP. The only independent predictor of CSFP was neutrophil-to lymphocyte ratio (NLR).