jimnoneill/paper-to-field-training huggingface dataset:
Supplementary Fig 1 from Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma

Field: Medicine (Health Sciences)

<p>Supplementary Figure 1. The levels of proteins and enzyme subunits involved in OXPHOS and glutamine metabolism increase with lung tumor progression. A, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of the OXPHOS protein HCCS. B, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of the glutamine transporter SLC1A5. C, Representative H&E and IHC images of lung tissue sections from KLLuc mice showing levels of GLS. Shown are montage images of lung tissue sections stained with H&E (row 1), montage images stained with DAPI (row 2) or antibodies against the indicated protein (row 3), and 10X images of lung tissue sections stained with DAPI (row 4) or antibodies against the indicated protein (row 5). The light green lines in DAPI montage images outline the tumors in the lung. The blue rectangles in H&E and white rectangles in DAPI montage images denote the regions shown in 10X. Scale bar, montage, 1mm; 4X, 200 Âµm; 10X, 100Âµm. D, Graph showing quantified levels of HCCS correlating with A. E, Graph showing quantified levels of SLC1A5 correlating with B. F, Graph showing quantified levels of GLS correlating with C. Protein levels were quantified, and data are plotted as mean {plus minus} SEM. G, Representative 40X IHC images of lung tissue sections showing the co-localization of ATP5F1A, COX7B, and CYCS with the mitochondrial marker TOMM20. Scale bar, 10 Âµm. H, OCR of NSCLC H226 cells cultured in normal medium, or heme depleted medium with 0.5 mM succinyl acetone (HD+SA). Heme (5 ÂµM, 10 ÂµM, and 20 ÂµM, respectively) was added back to examine the effects of heme on OCRs. For statistical analysis, the levels in cells with heme added back were compared with the levels in cells without heme added back with a Welch two-sample t test. **, P<0.005.</p>
Accuracy Standards and Data Coverage Requirements for Model Validation in FSUTMS

Field: Decision Sciences (Social Sciences)

Model validation is an important step in travel demand modeling. It serves to ensure that the calibrated model produces outputs that are consistent with the observed data. In the Florida Standard Urban Transportation Model Structure (FSUTMS), various consistency checks for the validation of the distribution and assignment models are suggested for highway networks. These checks involve the comparison of predicted link volumes with ground counts at screenlines, cordon lines, and/or cutlines. Statistics such as systemwide vehicle-miles-traveled (VMT), vehicle-hours-traveled (VHT), link volume by facility type, area type, facility size (in term of number of lanes), and volume group Root Mean Square Error (RMSE) are major criteria used for validation. Errors between model outputs and what are observed from the actual networks may come from such sources as measurement, sampling, model misspecification, prediction, and aggregation process. In this study, sampling and model misspecification errors were considered in deriving accuracy standards for highway networks. The required number of count stations to be sampled for each type of facility to achieve a specific accuracy standard at a certain level of confidence was also derived and a general rule of thumb was recommended for validation purposes. For transit networks, the accuracy standards were derived to account for statistical variability, aggregation errors, and prediction errors. Errors in modal share subjected to aggregation and prediction variability were derived for both multinomial logit and nested logit models. However, no results are presented due to a lack of data support.
B291 Low dose of spinal administration of levobupivacaine in combined spinal epidural anesthesia with epidural volume extention for cesarean section in two pregnants with multiple sclerosis

Field: Medicine (Health Sciences)

Background and Aims

Multiple sclerosis (MS) is a relapsing and remitting disease that may include symptoms of sensory or motor deficits, optic neuritis, bowel or bladder dysfunction, ataxia. Epidural administration of LA for cesarean delivery has historically been thought to be less risky for patients with MS than a spinal technique. This report related to the use of low dose combined spinal epidural anesthesia and epidural volume extension for cesarean section in two pregnant with multiple sclerosis

Methods

Two pregnant, 34 and 38 years old, are scheduled for an elective cesarean section for obstetric reasons. After informal consent and the same characteristics of gestation without complication, asymptomatic disease of MS for years and standard monitoring, combined spinal epidural technique was performed with the women in sitting position, level L3-L4, with intrathecal administration of 1,6 ml Levobupivacaine 0,5% + fentanyl 20γ and placed epidural catheter.

Results

After 10 minutes the sensitive block was achieved at T8 level. 5 ml of epidural saline was administrated and 5 minutes later the sensitive block was at T6. The women remained with stable blood pressure and cardiac rhythm with low dose of neosynephrine. The cesarean sections developed without complications. Into the Recovery Room the patients had Grade II motor blockade (Bromage scale) without complications.

Conclusions

A small dose of spinal Levobupivacaine can induce adequate analgesic levels with lower incidence of hypotension and motor block (in relation to sensitive) and the epidural injection of saline afterwards stabilize the safety and duration of analgesia to these patients, offers advantages over alternative techniques.
A kinetic study of the reaction between terephthalic acid and ethylene oxide at atmospheric pressure

Field: Chemical Engineering (Physical Sciences)

Abstract The kinetics of the reaction of terephthalic acid with ethylene oxide, in n‐butanol solvent, catalysed by triethyl amine, were investigated in a semi‐batch reactor under atmospheric conditions. It was found that the reaction occurred in the liquid phase and that mass transfer effects were absent. The reaction was found to be pseudo‐zero order in terephthalic acid and first order in ethylene oxide and in catalyst concentration. The effects of reaction temperature, catalyst concentration, particle size of terephthalic acid, ethylene oxide flow rate, stirrer speed and terephthalic acid to ethylene oxide ratio were studied. Particle size of terephthalic acid, stirrer speed and flow rate of ethylene oxide did not affect the reaction rate. The Arrhenius activation energy of the reaction was found to be between 19.2 and 23.5 kcal/mol.
Access To Justice In Plural Legal Systems: A Case Study Of Customary And State Law Integration In Sub-Saharan Africa

Field: Social Sciences (Social Sciences)

This study explores access to justice in plural legal systems by examining the integration of customary law and state law in Sub-Saharan Africa. In many African states, legal pluralism is a historical and social reality, with indigenous customary practices coexisting alongside colonial-derived formal legal frameworks. While state law often claims supremacy, customary law remains the primary source of dispute resolution for a significant proportion of the population, especially in rural areas. This case study investigates how the interaction between these two systems affects legal accessibility, fairness, and legitimacy. Through a qualitative case study methodology involving document analysis and secondary data, the research highlights both the complementarities and tensions between the two legal regimes. The findings suggest that harmonizing customary and state law—through mutual recognition, procedural safeguards, and institutional cooperation—can enhance inclusive justice outcomes. However, unresolved issues related to gender equality, due process, and jurisdictional ambiguity persist. The study concludes that plural legal systems, when effectively integrated, offer a promising pathway to justice that is both contextually relevant and socially legitimate
Multifunctional Polymer Vesicles for Synergistic Antibiotic–Antioxidant Treatment of Bacterial Keratitis

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

As an acute ophthalmic infection, bacterial keratitis (BK) can lead to severe visual morbidity, such as corneal perforation, intraocular infection, and permanent corneal opacity, if rapid and effective treatments are not available. In addition to eradicating pathogenic bacteria, protecting corneal tissue from oxidative damage and promoting wound healing by relieving inflammation are equally critical for the efficient treatment of BK. Besides, it is very necessary to improve the bioavailability of drugs by enhancing the ocular surface adhesion and corneal permeability. In this investigation, therefore, a synergistic antibiotic-antioxidant treatment of BK was achieved based on multifunctional block copolymer vesicles, within which ciprofloxacin (CIP) was simultaneously encapsulated during the self-assembly. Due to the phenylboronic acid residues in the corona layer, these vesicles exhibited enhanced muco-adhesion, deep corneal epithelial penetration, and bacteria-targeting, which facilitated the drug delivery to corneal bacterial infection sites. Additionally, the abundant thioether moieties in the hydrophobic membrane enabled the vesicles to both have ROS-scavenging capacity and accelerated CIP release at the inflammatory corneal tissue. In vivo experiments on a mice model demonstrated that the multifunctional polymer vesicles achieved efficient treatment of BK, owing to the enhanced corneal adhesion and penetration, bacteria targeting, ROS-triggered CIP release, and the combined antioxidant-antibiotic therapy. This synergistic strategy holds great potential in the treatment of BK and other diseases associated with bacterial infections.
Cultural and Political Hegemony in Abawi's The Secret Sky

Field: Arts and Humanities (Social Sciences)

Hegemony is the domination of a governing class over the values, beliefs and the perceptions of a culturally diverse society. Cultural conflicts between various tribes of a community wherein the dominant tribe claims its authority either by imposing its own ideologies or by demeaning the cultural values of other tribes. When a dominant group fails to acquire consensual control over another group, which they consider inferior, it lost its hegemony. This study delimits Abawi's The Secret Sky and Antonio Gramsci’s theorization of hegemon to argue how hegemonic powers in Afghanistan operate on political and cultural levels. This study is significant for its (con) textual approach to highlight the purpose of foreign invasions to hegemonies the culture of Afghan locale.
SOCIOECONOMIC STATUS - EFFECTS AND IMPLICATIONS FOR SPECIAL EDUCATION PLACEMENT

Field: Social Sciences (Social Sciences)

________Brandner Kristine K. ___ (Last Name) (First Name) (Initial) __________ Socioeconomic Status – Effects and Implications for ____________ (Title) _____ ____________Special Eduation Placement____ _________ ___ __Education________Dr. Edwin Biggerstaff__March, 2004 _________47_____ (Graduate Major) (Research Advisor) (Month/Year) (No. of Pages) ______________American Psychological Association, 5 edition _______________ (Name of Style Manual Used in this Study) The purpose of this study was to determine if socioeconomic status played a role in special education referrals and placements. This study included a comprehensive review and critical analysis of research and literature concerning special education, the referral process, and socioeconomic status to determine if there was a relationship between socioeconomic status and placement of students in special education. Conclusions were drawn and recommendations were given for parents, educators, and administrators as well as school districts. Research has suggested that the steps are in place to intervene in struggling student’s education in some school districts. Programs were set up during the school
Disability Theology Despite Itself

Field: Arts and Humanities (Social Sciences)

This article examines the biography, literature, and religious thought of Shi Tiesheng (1951–2010), arguably the most influential author with a disability in contemporary China. Using the definition of “theology” in its broad sense, it argues that Shi has developed a kind of disability theology through his non-fiction and fictional works, though he never claimed to be a theologian or saw his works as theological. This theology borrows terms and ideas from Christianity, but also follows the syncretic tradition of Chinese religions. In contemporary China, where religions have been marginalized, religious vocabulary and contemplation helped Shi break free of the narrative assigned to people with disabilities by the atheist state.
Adapting ECG morphology changes from reduced-lead set by specifically trained algorithms for acute ischemia detection

Field: Medicine (Health Sciences)

The reduced lead set in this study consists of a subset of 12-lead set with all the same limb leads, plus v1 and v5 chest leads. They were then converted to 12-lead signals with a trained matrix. The aims of this study are to evaluate the changes of morphology due to the conversion and the possibility of adapting the changes with the new criteria trained with a large ischemia ECG database. For the evaluation, we first applied the standard 12 lead computerized algorithm to the converted 12-lead ECGs. We then applied 2 training algorithms to the converted 12-lead ECG to obtain the specific criteria. One algorithm is based on neural network models, and the other is based on the binary-tree classification model with automatically induced rules (C4.5). The study used the chest pain databases from Mayo Clinic and Medical College of Wisconsin, which include ECGs from 993 anterior MI patients, 1187 inferior MI patients and 1987 Nonischemic patients based on their final confirmation with Cathlab or Biomarker tests. The results show that, without retraining, the reduced-lead set achieved 53% sensitivity for Inferior MI, compared with 54% from standard 12-lead set, and with both specificity of 99%. For anterior MI, the sensitivity of reduced lead set is 37%, compared to the 46% for standard 12 lead. After retraining, the reduced lead set has a sensitivity of anterior MI 56%, compared to a retrained standard 12 lead set of 57%, with specificity above 98% for both lead sets.
Gate-keeping or free choice in crisis resolution and home treatment teams

Field: Health Professions (Health Sciences)

Crisis resolution and home treatment (CRHT) teams have been introduced into mental health care in the UK because, in general, patients do not want to be admitted to hospital, treatment at home is cheaper and in the only randomized controlled trial conducted so far there was no difference in symptomatic outcome. However, because of compulsory gate-keeping by CRHT teams, some patients no longer have the option of going to hospital if they want to. This aspect of the introduction of CRHT teams has not been discussed so far, but it certainly warrants further examination. Intervention through CRHT teams may in fact increase compulsory admissions and serious and untoward incidents, although this is not certain. Sufferers from psychosis are the patient group most likely to be compulsorily admitted to hospital and they are generally considered less responsible for serious and untoward incidents. Therefore, a possible solution could be to offer a choice to some patients, namely those with a psychotic disorder, on whether they want to be admitted or not. At least one should investigate what the consequences of this policy would be, if it were to be adopted in a test region. This example shows that in developing policies for rationing health care, it can be important to look at subgroups and not just at average results when determining the best course of action.
Canine encephalitozoonosis in South Africa.

Field: Veterinary (Health Sciences)

Clinical, clinicopathological macroscopical and histopathological findings, as well as electron microscopic and cultural confirmation, in twelve natural cases of canine encephalitozoonosis are described, eleven of these under one year of age. Nervous symptoms, including blindness, retarded growth rate and nephritis are prominent clinical signs. The macroscopic findings and histopathology proved of great help in the diagnosis of the disease even in chronic cases. The organism was cultured and some distinguishing electron microscopical features between Encephalitozoon and Nosema are discussed. A transmission experiment confirmed the diagnosis. The results are compared with the reported cases in dogs and Blue Foxes (Alopex lagopus).
Personality and Stress in Consultant Psychiatrists

Field: Psychology (Social Sciences)

A randomly selected group of consultant psychiatrists (n = 39) working within the NHS in Scotland was compared with a combined group of physicians and surgeons (n = 149) on several variables related to the stress process, including personality traits, coping strategies, psychological distress, burnout, job stress and work demands. Psychiatrists reported fewer clinical work demands (p < .001), and their mean personality scores were significantly different from physicians and surgeons by being high in neuroticism (p = .009), openness (p = .003) and agreeableness (p = .002), and low in conscientiousness (p = .04). Psychiatrists reported higher work-related emotional exhaustion (p = .03) and severe depression (p = .02). However, psychiatrists did not report more work-related stress than physicians and surgeons. Many stress-related variables were highly correlated within the group of psychiatrists, suggesting that there is a very general disposition to experience negative emotion (including job-related stress) in some individuals. Organisational and personal contributions to stress in the practice of psychiatry are considered. There are personality characteristics that might dispose some people toward psychiatry as a career and toward stress. However, there is no evidence to suggest that screening for admission to psychiatry in terms of per sonality or other psychological factors would be useful or advisable.
EFFECTS OF WOMEN ENTREPRENEURIAL DEVELOPMENT ON DOMESTIC VIOLENCE REDUCTION IN NIGERIA

Field: Social Sciences (Social Sciences)

The study was conducted to examine the effects of women entrepreneurial development on domestic violence reduction in Nigeria. A mixed method approach was used and the population of the study constituted selected women entrepreneurs across Nigeria. The study sampled 839 respondents using Top-man formula for sample size determination. The instrument for the study was questionnaire that used likert scale format. The study adopted content validity for the instruments and Cronbach alpha method of internal consistency to determine the reliability of the questionnaire. Data analysis was carried out using multiple regressions with the aid of content thematic analysis of SPSSv21. The study concluded that women who engaged in entrepreneurial activities support their homes; and they were considered as assets not liabilities by their husbands and therefore, earn respect. Domestic violence against women constitutes a major setback to agricultural activities in the Study Area. The study, therefore, recommended that women should be given every encouragement both financially and emotionally to embark on entrepreneurial activities such as opportunities to occupy reasonable positions in government both politically and career appointments to display their talents; and the farmers especially from the women extraction be given full protection against herdsmen at both on farms and at home. There is also need for non-governmental organizations (NGOs) who are also key components in any sustainable human development agenda to end or reduce violence against women by rendering community services through the creation of adequate awareness to the general public.
Transcriptome Profiling of Potato (Solanum tuberosum L.) Responses to Root-Knot Nematode (Meloidogyne javanica) Infestation during A Compatible Interaction

Field: Agricultural and Biological Sciences (Life Sciences)

Root-knot nematode (RKN) Meloidogyne javanica presents a great challenge to Solanaceae crops, including potato. In this study, we investigated transcriptional responses of potato roots during a compatible interaction with M. javanica. In this respect, differential gene expression of Solanum tuberosum cultivar (cv.) Mondial challenged with M. javanica at 0, 3 and 7 days post-inoculation (dpi) was profiled. In total, 4948 and 4484 genes were detected, respectively, as differentially expressed genes (DEGs) at 3 and 7 dpi. Functional annotation revealed that genes associated with metabolic processes were enriched, suggesting they might have an important role in M. javanica disease development. MapMan analysis revealed down-regulation of genes associated with pathogen perception and signaling suggesting interference with plant immunity system. Notably, delayed activation of pathogenesis-related genes, down-regulation of disease resistance genes, and activation of host antioxidant system contributed to a susceptible response. Nematode infestation suppressed ethylene (ET) and jasmonic acid (JA) signaling pathway hindering JA/ET responsive genes associated with defense. Genes related to cell wall modification were differentially regulated while transport-related genes were up-regulated, facilitating the formation of nematode feeding sites (NFSs). Several families of transcription factors (TFs) were differentially regulated by M. javanica infestation. Suggesting that TFs play an indispensable role in physiological adaptation for successful M. javanica disease development. This genome-wide analysis reveals the molecular regulatory networks in potato roots which are potentially manipulated by M. javanica. Being the first study analyzing transcriptome profiling of M. javanica-diseased potato, it provides unparalleled insight into the mechanism underlying disease development.
Poa pratensis L., GR 4594

Field: Agricultural and Biological Sciences (Life Sciences)

PGRFA accession of IPK Gatersleben Plant Genetic Resource Taxon: Poa pratensis L. Accession number: GR 4594 Conserved by: DEU271 Acquisition: 1973-09-01 Origin country: DEU Biological status: Wild MLS status: Included AEGIS status: Included Historic: No