jimnoneill/paper-to-field-training huggingface dataset:
RAT BONE MARROW STROMAL CELLS HAVE POTENTIAL TO DIFFERENTIATE INTO NEURONS,GLIAS AND PHOTORECEPTORS AFTER INDUCED BY SUPERNATANT OF CULTURED RETINAL CELLS

Field: Neuroscience (Life Sciences)

Objective To investigate the effects of supernatant from cultured retinal cells on the differentiation of bone marrow stromal cells(BMSCs) in vitro. Methods Supernatant of cultured embryonic 17 days and postnatal 3 days retinal cells were collected,filtrated and mixed with DMEM at a ratio of 2:3 respectively.BMSCs were induced by two different mixed culture medium,observed under phase contrast microscope,then characterized by immunostained with NF,GFAP and retinal specific antibodies,positive cells were counted and analysed,RT-PCR was used to further confirm the immunocytochemical results. Results BMSCs expressed NF and GFAP after induced by both supernatant.The percentage of NF positive cells were(10.35±2.66)% and(10.64±3.94)% and that of GFAP positive cells were(27.86±7.97)% and(24.38±5.80)% after induced by E17 and P3 supernatant.In addition only induced BMSCs by supernatant from P3 retinal cells were imrnunostained positive in opsin,a specific antibody of photoreceptors;After 3 weeks induction,Crx,a transcription factor of photoreceptor development was detected in BMSCs induced by P3 supernatant by RT-PCR,and not any retinal specific antibody was stained positive in BMSCs induced by El7 supernatant.Conclusion BMSCs have potential to differentiate into neurons,glials induced by supematant of cultured retinal cells.BMSCs induced by supernatant of postnatal retinal cells retinal cells can differentiate into retinal cells.
The Drosophila F-box protein Fbxl7 binds to the protocadherin Fat and regulates Dachs localization and Hippo signaling

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The Drosophila protocadherin Fat (Ft) regulates growth, planar cell polarity (PCP) and proximodistal patterning. A key downstream component of Ft signaling is the atypical myosin Dachs (D). Multiple regions of the intracellular domain of Ft have been implicated in regulating growth and PCP but how Ft regulates D is not known. Mutations in Fbxl7, which encodes an F-box protein, result in tissue overgrowth and abnormalities in proximodistal patterning that phenocopy deleting a specific portion of the intracellular domain (ICD) of Ft that regulates both growth and PCP. Fbxl7 binds to this same portion of the Ft ICD, co-localizes with Ft to the proximal edge of cells and regulates the levels and asymmetry of D at the apical membrane. Fbxl7 can also regulate the trafficking of proteins between the apical membrane and intracellular vesicles. Thus Fbxl7 functions in a subset of pathways downstream of Ft and links Ft to D localization.
doi:10.1155/2011/535983 Clinical Study Efficacy and Safety of Low-Dose Cyclosporine with Everolimus and Steroids in de novo Heart Transplant Patients: AMulticentre,

Field: Medicine (Health Sciences)

Copyright © 2011 Andreas Zuckermann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A six-month, multicenter, randomized, open-label study was undertaken to determine whether renal function is improved using reduced-exposure cyclosporine (CsA) versus standard-exposure CsA in 199 de novo heart transplant patients receiving everolimus and steroids ± induction therapy. Mean C2 levels were at the low end of the target range in standard-exposure patients (n = 100)
Psychological distress and quality of community life among migratory construction workers in India

Field: Psychology (Social Sciences)

Objectives: The objectives of this study are to elicit sociodemographic details, assess the level of psychological distress, and measure the quality of community life (QoCL) of migratory construction workers. Materials and Methods: A cross-sectional research design and survey method of sampling was followed. The semi-structured interview schedule, self-reporting questionnaire, and QoCL scale were used as measures for the study. Results: Out of 75 respondents, 37 (49.3%) did not have formal education, 38 (50.7%) have migrated for less than a month duration, 33 (44.0%) respondents migrated with their families. The mean age of respondents was 32.03 ± 9.82 years. About 48 (64.0%) were identified as potential respondents for psychosocial care and female respondents (M = 12.90 ± 4.03, t = −3.03, P < 0.003) have higher distress than males (M = 9.50 ± 4.56, t = −3.03, P < 0.003) ones. Overall, QoCL indicated a below moderate (59.08 ± 8.31) level. Conclusion: The distress was high and QoCL indicated a below moderate level. Intersectoral and community mental health services were required to enhance QoCL and reduce distress among migratory construction workers.
A Study of Inclement Weather Impacts on Freeway Free-Flow Speed

Field: Engineering (Physical Sciences)

The research presented in this thesis attempts to investigate the impact of detector failure frequency and failure duration on the accuracy of loop detector speed, flow, and density measurements using a Monte Carlo simulation approach. The inputs to the model are the frequency of failures and failure duration. Several regression models were developed to relate loop detector accuracy to detector failure data. The results showed that the models were consistent and similar for the same location with an R square that ranged between 86% and 94% for all models and in comparing two locations, the differences between the regression models were minor except for the flow model errors, the location had the same trend but the magnitude of the flow RMSE increased by 7.5 to 15%.\n\nThe second part of the research effort attempts to quantify the impact of inclement weather (precipitation and visibility) on traffic stream free-flow speeds along freeway sections. The analysis is conducted using weather (precipitation and visibility) and loop detector data (speed) obtained from Baltimore, Minneapolis/St. Paul, and Seattle, US. The results demonstrate that visibility alone has a minimum impact on free-flow speed with reductions in the range of 1 to 3%. These reductions only appear as the visibility level falls below 1.2 km. The study demonstrates that the impact of snow is more significant than that of rain for similar intensity levels. Reductions caused by rain are in the neighborhood of 2 to 5% depending on the precipitation intensity while reductions caused by snow are in the neighborhood of 6 to 20%. With regards to freezing rain, higher reductions in free-flow speed were observed when compared to rain and snow. Specifically, the free-flow speed was reduced by 14% at the onset of freezing rain precipitation with a maximum decrease of 27% at freezing rain intensity of about 0.53 cm/h for Baltimore and as the case of Seattle the reduction was found to be constant with 31%.\n\nFinally, the paper derives free-flow speed reduction factors that vary as a function of the precipitation type and intensity level. These reduction factors can be incorporated within the Highway Capacity Manual's procedures.
Depletion of small reservoirs in a semiarid region based on remote sensing

Field: Environmental Science (Physical Sciences)

This thesis shows a way to model water flows during the dry season of a semiarid region in Brazil. The eventual goal to which this thesis is a start, is to be able to use remote sensing as a way of predicting the water decay of reservoirs which are too small and therefore too costly to monitor using permanent monitoring devices or highly intensive fieldwork. To get an idea of the local population and because there is little information available, interviews have been held in the studied area with the inhabitants. Using this way of gathering information the average household composition has been established for the communities. Also the use of different available water sources are clarified during the interviews.
With the use of open source satellite images areas have been measured of water surfaces and vegetation areas during the year to be used in a model. This model is an earlier developed model which is used in similar semiarid regions and is able to connect reservoir shape, volume, water height and water surface area during a period of time to each other combined with evaporation values and water balance flows. The results of these measurements are then compared to on-site measurements.
Effect of the Base-band Measurement Setup Errors on DPD Performance and Elimination Procedure

Field: Engineering (Physical Sciences)

In this study, the effect of base-band measurement setup errors on DPD performance was investigated and a calibration procedure is developed to eliminate the measurement errors. A base-band measurement setup is prepared at laboratory with instruments and then the data which is measured and the deteriorating effect of errors on Digital Predistortion (DPD) linearization performance are investigated. In order to eliminate deteriorating effect of this error a three steps calibration procedure is developed. Before and after calibration application DPD performance is measured. It is showed both in simulation and experimentally that the calibration procedure improved the DPD system linearization performance from 10 dB to 26dB and 13dB to 20dB, respectively.
Numerical investigations of dynamic moisture response to the climates inside wooden components in timber buildings and its potential threats

Field: Environmental Science (Physical Sciences)

Chinese historical timber buildings are famous for their exquisite craftsmanship. In China, there are various climates with significant fluctuations throughout the year. As some buildings are designed with an open style, many wooden components are exposed to environments with drastic changes in humidity, and the moisture content inside the wood may fluctuate significantly with the changing environment. To protect these architectural heritages from damage, here, numerical simulations were conducted to evaluate the effect of periodic climate conditions on moisture transfer inside wooden components. Five representative cities in China were chosen for comparison, and the long-term variations and dynamic responses of moisture content to periodic climate conditions were investigated. The results show that the moisture content inside the wood varies from 5% to 20% across different cities and months. The plaster layer, made from a mixture of lime, hemp, animal blood, and tung oil, serves as a waterproof coating to prevent significant moisture gradients within the wood. It also reveals that the dynamic moisture response to the climate may pose threats to historical buildings. By analyzing the potential risks, such as mechanical properties, fungal attacks, and fire hazards, this paper provides suggestions for the preservation of timber buildings with different climates in China.
Improving quantification and identification in metabolomics

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Chapter 1 introduces and discusses metabolomics and related analytical techniques such as NMR, direct infusion-MS, GC-MS, and LC-MS. Next LC-MS-based untargeted metabolomics, including metabolite sample collection and preparation and untargeted LC-MS analysis platforms, are discussed. Chapter 2 apply the dynamic mass error theory to improve the quantification of metabolites. The aim of this project is the implementation of the dynamic binning algorithm, which considers the exact width broadening of a peak in mass spectra to construct extracted ion chromatograms (EICs), and which provides more accurate quantification than using EIC constructed with linear or constant thresholds implemented in the most widely used metabolomics software, XCMS. Chapter 3 describes applying dynamic thresholds to improve untargeted metabolite identification and includes the PEP score and q-value calculation to provide an estimated ensemble and individual error for untargeted metabolomics identification. Chapter 4 includes lipid identification and quantification. The transcriptomic data show that Vitamin B12, cofactor biosynthesis pathways, and ribosomal proteins are activated upon CP treatment. Especially the genes related to phospholipid biosynthesis and fatty acid are differentially expressed. These changes upon CP were further affirmed by the cell membrane’s composition change of fatty acids and phospholipids, as shown by both phospholipid composition and the membrane fluidity measurements. The growth inhibition of F. prausnitzii upon CP exposure can be explained by the cell membrane lipid composition and fluidity changes. Chapter 5 describes an R package with a graphic user interface, which enables untargeted metabolomics data pre-processing and analysis without programming skills.
Characterization of electric consumers through an automated clustering pipeline

Field: Computer Science (Physical Sciences)

Clustering analysis of daily load profiles represents an effective technique to classify and aggregate electric users based on their actual consumption patterns. Among other purposes, it may be exploited as a preliminary stage for load forecasting, which is applied in the same way to consumers in the same cluster. Several clustering algorithms have been proposed and developed in the literature, and the choice of the most appropriate set of clustering parameters is crucial for ensuring reliable results. In this paper, an automated service, suited for repeated clustering analysis, is presented. The pipeline is able to process a generic time series dataset and is easily adjustable to test other clustering input parameters; therefore, it may be utilized to find the best set of parameters with the specific dataset. Moreover, it facilitates repeated characterization on real-time load profiles with the aim of detecting sudden changes of consumers behaviors and variable external conditions, which influence the real power forecasting activity on a short temporal scale.
The Geography of Need: Spatial Distribution of Barriers to Employment in Metropolitan Detroit

Field: Social Sciences (Social Sciences)

Although several studies examine the barriers to employment that limit the employability of welfare recipients, they have not analyzed how these barriers might be different for residents of central cities than for residents in surrounding suburban areas. We consider how the prevalence of barriers to employment varies by race and place in metropolitan Detroit. We find that the prevalence of mental health, substance abuse, and domestic violence barriers is higher in suburban areas, and that structural barriers are higher in the central city.
Institutional Trading, Information Production, and the SEO Discount: A Model of Seasoned Equity Offerings

Field: Economics, Econometrics and Finance (Social Sciences)

We develop a model of the seasoned equity offering (SEO) process, starting from the SEO announcement, through pre-offer trading, and ending in the offering itself. We use our model to advance a new rationale for the existence of the SEO discount and SEO underpricing, and to analyze the role of institutional investors in SEOs. We show that the SEO discount is positively related to the extent of information asymmetry a firm faces, and SEOs with greater pre-offer net buying by institutional investors have higher institutional allocations, greater oversubscription, and lower SEO discounts. Furthermore, our model predicts a positive link between the pre-offer net buying by institutional investors and the magnitude of SEO underpricing and the long-run post-SEO operating performance.
THE INTERSECTION OF RELIGION AND PAKISTAN'S FOREIGN POLICY DECISIONS: A COMPREHENSIVE STUDY

Field: Social Sciences (Social Sciences)

This research paper outlines a framework for understanding and analyzing the influence of religion on foreign policy in the context of the 'post-secular' shift in internationa l relations. As religion becomes progressively relevant to statecraft and foreign policymaking, its impact varies significantly across various states. The primary aim of this research is to examine the influence of religion on the foreign policy choices of Pakistan and to compare these influenc e s with those affecting India's foreign policy. By exploring these dynamics, the research seeks to uncover the possible implications for Pakistan and to identify how Pakistan can leverage religion as a tool of soft power in its statecraft methods. Furthermore, this study aims to contribute to the broader discourse on the role of religion in global politics, providing insights that could inform diplomatic strategies and international relations theory. Ultimately, the findings could help policymakers understand the nuanced ways in which religious factors shape internationa l interactions and state behavior.
Analysis of causative microorganisms and choice of antibiotics according to the onset of neonatal sepsis

Field: Medicine (Health Sciences)

접수 : 2006년 2월 20일, 승인 : 2006년 4월 6일 책임저자 :최영륜, 전남대학교병원 소아과 Correspondence : Young Youn Choi, M.D. Tel : 062)220-6642 Fax : 062)222-6103 E-mail : yychoi@chonnam.ac.kr 질환, 신경질환, 혈액질환 등이 있는데 이들 모두 패혈증 증상과 유사하므로 감별이 필요하다. 1933년 Dunham 1) 이 신생아 패혈 증에 관한 광범위한 관찰을 보고한 이래 여러 보고들이 있었으 며, 아직도 신생아기 사망의 상당한 비중을 차지하고 있다 2-5) . 패혈증은 조기에 적절한 치료를 시행하지 않으면 중증 패혈증, 패혈증 쇼크, 다발성 장기부전 및 사망으로 진행할 수 있으므로 임상증상과 몇 가지 검사소견으로 의심이 되면 원인균 동정 및 항생제 감수성 결과가 나오기 전에 증상의 발현 시기나 그 지역 또는 신생아실에서 흔한 원인균을 고려하여 경험적인 항생제치 료를 시작해야 한다 6-8) . 이에 저자들은 전남대학교병원 신생아중 환자실에서 신생아 패혈증의 발생시기에 따른 원인균과 임상양 상에 대해 알아보고 항생제 선택의 지침을 마련하고자 하였다. 신생아 패혈증에서 발현시기에 따른 원인균 분석과 항생제 선택
Is This Even Possible?: Co-creating University and Industry Learnings for Immersive Experiences

Field: Computer Science (Physical Sciences)

This article discusses an ambitious university-industry collaboration based at the University of South Wales that was designed to further develop digital storytelling practice within the UK Creative Industries. During this UKRI-funded, Audience of the Future R&D demonstrator project, the authors collaborated with Bristol-based animation studio Aardman, who were both licensors and content contributors for an immersive transmedia experience called The Big Fix Up based on the globally loved Wallace and Gromit intellectual property. Working closely with Aardman, the consortium drew upon their combined skills in games production, animation, creative marketing and new technology development to create a mobile application that marries Wallace and Gromit with mobile storytelling and the latest augmented reality and mixed reality technologies. One of the key aims of this larger industry-led demonstrator programme was to propel new immersive storytelling insights informed by extensive audience research. In their article, Davies and Patrickson examine this university-industry collaboration in methodological terms, outlining the factors that enabled them to negotiate cross-sector issues whilst reflecting on the multi-faceted approach to audience research that emerged from those negotiations.
Observation of Transient Nutation Effect in Microwave Transitions of Ammonia Molecule

Field: Physics and Astronomy (Physical Sciences)

Transient nutations in the J = K , J = K +1, and J = K +2 inversion transitions of ammonia are observed by applying repetitive pulse voltage to the repellor of a klystron. The reciprocal of the damping time constant T 2 increases linearly with the pressure in the range of 6 mTorr to 50 mTorr, and depends on J and K in the same manner as the linewidth. The magnitude of 1/2π T 2 for each transition is found to be systematically smaller than the corresponding linewidth measured by Legan et al. The linewidths are remeasured on the J =3, K =3 and J =3, K =2 transitions, and a reasonable agreement with 1/2π T 2 is obtained.
Observation on the effects of Qi Dan wasting-thirst dose combined with Western medicine treatment for early diabetic nephropathy

Field: Medicine (Health Sciences)

Objective To investigate the therapeutic effects of Qi Dan wasting-thirst dose combined with Western medicine treatment for early diabetic nephropathy.Methods To choose 78 cases diabetic nephropathy patients,and were randomly divided into observation group and control group,39 cases for each group,the control group was treated with conventional therapy,and the observation group was treated with the way of the control group and added traditional Chinese medicine compound prescriptions Qi Dan wasting-thirst dose to take orally.Four weeks for one course of the treatment,two groups were all treated for three course of the treatments.To observe the target change of urinary albumin excretion rate(UAER),24 hours urinary protein quantity,β2-micro-globulin( β2-MG),serum albumin(ALB),serum creatinine(SCr),alanine aminotransferase(ALT) and so on,after or before the treatment.Results The end of course of the treatment,the UAER,24 hours urinary protein quantity,β 2-MG and SCr level in the observation group were evident lower,and the untoward effects were less in the course of the treatment,the total effective rate of the observation group was 87.18％,and the total effective rate of the control group was 58.97％,there were statistical significance in two groups(P＜0.05).Conclusion Qi Dan wasting-thirst dose combined with Western medicine treatment for early diabetic nephropathy has exact effect.

Key words:
Diabetic nephropathy; Qi Dan wasting-thirst dose; Combination of Chinese traditional and Western medicine
Analysis of leptospirosis notifications in children and adolescents treated at a Reference Hospital in Santa Catarina from 2016 to 2021

Field: Medicine (Health Sciences)

OBJECTIVE: To identify the epidemiological leptospirosis profile in the pediatric population (0 to 15 years old), as well as to analyze and review clinical data, in order to contribute with public health policy strategies and point out the importance of leptospirosis and its notification by the health authorities. METHODS: An epidemiological, observational, analytical and cross-sectional study of 101 leptospirosis notification forms, CID10- A27.9, notified by epidemiological surveillance nucleus of a tertiary pediatric hospital, from January 2016 to December 2021, this research was submitted and approved by the institutions Ethics Committee. RESULTS: Of the 101 notifications, 13 (12.9%) had clinical and laboratory diagnostic confirmation for leptospirosis, 12 (92.3%) in males, from peri-urban areas; the greatest source of exposure was river, stream, lagoon or dam representing 7 (53.8%) cases. CONCLUSION: The predominant profile is a boy, resident of the peri-urban area, the clinical has nonspecific and self-limited symptoms.
Efficacy of mycophenolate mofetil in patients failing 6-mercaptopurine or azathioprine therapy for Crohn's disease

Field: Medicine (Health Sciences)

Mycophenolate mofetil (MMF) is a novel immunomodulator that may be effective in the treatment of chronic active and perianal Crohn's disease (CD). The aim of this study is to assess the efficacy of MMF in CD patients who failed or were intolerant of 6-mercaptopurine (6-MP) or azathioprine (AZA). Eleven CD patients were treated with MMF after a failed course of 6-MP/AZA, and their records reviewed retrospectively. Reasons for 6-MP/AZA intolerance or failure were recorded. Response to MMF was determined by calculation of the Harvey-Bradshaw index and ability to taper steroids. Adverse reactions to MMF were recorded. Eleven patients were identified who failed a previous trial of 6-MP/AZA and other immunomodulators and required immunomodulator therapy. Of 11 patients who started MMF, four had early adverse reactions within 8 weeks and stopped the medication. Of the remaining seven patients who took MMF for at least 8 weeks, one had a complete response, two had a partial response, and four had no response to the medication. In patients who failed 6-MP/AZA, MMF was of benefit in 3 of 11 patients with only one complete responder. This lower-than-expected response rate may indicate that patients who are resistant to 6-MP or AZA may also be resistant to MMF.