jimnoneill/paper-to-field-training huggingface dataset:
Scolicidal and Apoptotic Activities of 5-hydroxy-1, 4-naphthoquinone as a Potent Agent against Echinococcus granulosus Protoscoleces

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Cystic hydatid disease (CHD) is a zoonotic disease with different clinical stages caused by the larval stage of the cestode Echinococcus granulosus. It is important to highlight as a public health problem in various regions of the world. In the current study, the efficacy and apoptotic activity of the liposomal system containing juglone (5-hydroxy-1,4-naphthoquinone) were assessed against protoscoleces (PSCs) in vitro. To this aim, firstly, liposomal vesicles were prepared by the thin-film method. Their physico-chemical features were assessed using Zeta-Sizer and Scanning Electron Microscope (SEM). Subsequently, various concentrations (50, 100, 200, 400, and 800 μg/mL) of juglone nanoliposomes at different exposure times (15, 30, 60, and 120 min) were used against PSCs. Results showed that juglone nanoliposomes at all tested concentrations induced scolicidal effect, however, 800 μg/mL and 400 μg/mL of juglone nanoliposomes could reach 100% mortality in 60 and 120 min, respectively. Additionally, we found that caspase-3 mRNA expression was higher in PSCs treated with juglone nanoliposomes compared to control groups (p < 0.001). Therefore, juglone nanoliposomes are suggested to have a more potent apoptotic effect on PSCs. Generally, optimized doses of juglone nanoliposomes could display significant scolicidal effects. Moreover, further in vivo studies are required to evaluate the efficacy of this nanoliposome.
What Every School Administrator Should Know about Equal Employment Opportunity Legislation

Field: Social Sciences (Social Sciences)

Managers unfamiliar with both the basic provisions of equal employment opportunity (EEO) legislation and subsequent interpretations by the courts could find themselves entangled in endless difficulties. School administrators who nowadays are perceived as management specialists do not escape this predicament. The following information should help them avoid some of the obvious pitfalls. As the federal government's leading EEO law enforcement agency, the Equal Employment Opportunity Commission (EEOC) enforces Title VII of the Civil Rights Act of 1964, which was amended in 1972 to prohibit employment discrimination based on race, color, religion, sex, or national origin. The EEOC also enforces the Equal Pay Act (EPA) of 1963, the Age Discrimination in Employment Act (ADEA) of 1967, and federal prohibitions against discrimination against disabled persons. Title IX of the Education Amendments of 1972 eliminates a former exemption for educational institutions, thus bringing teachers and professional and nonprofessional staff members within the act's coverage.
Renal tubular secretion of creatinine in the dog

Field: Medicine (Health Sciences)

Creatinine secretion in the dog has been studied under stop-flow conditions; 43 experiments were carried out in males and 14 in females. The mean free-flow and peak stop-flow creatinine U/P/inulin U/P in the males were 1.03 and 1.42, respectively. In 7 normal females the ratios were 0.95 and 1.14. Secretion could be demonstrated in the female if pretreated with testosterone. The results indicate creatinine secretion with proximal tubule localization. The nature of the transport system was studied and significant inhibition could be demonstrated with 2,4-DNP, organic mercurials, organic acids, and organic bases. The nature of the transport mechanism is discussed.
Studies on the Synthesis of Antiulcer Agents. VII. Synthesis and Antiulcer Activity of Dihydrobenzofuranone Derivatives

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

A number of 2-substituted 2,3-dihydro-3-oxo-5-benzofuranylacryloyl derivatives were synthesized and tested for antiulcer activities in order to study structure-activity relationships. Significant antiulcer activities were found in only the compounds (2e-g, p, s) in which hydroxymethyl and methyl groups or acetoxymethyl and methyl groups were introduced on the 2-position of the benzofuranone skeleton. Among the compounds tested, 1-[3-(2,3-dihydro-2-hydroxymethyl-2-methyl-3-oxo-5-benzofuranyl)acryloyl ] piperidine (2e) was the most promising compound.
The Association between Atherosclerotic Disease Risk Factors and Serum 25-Hydroxyvitamin D Concentration in Japanese Subjects

Field: Medicine (Health Sciences)

Recent studies have described that vitamin D deficiency/insufficiency is associated with hypertension, insulin resistance, and dyslipidemia, which are major components of metabolic syndrome causing atherosclerosis. Therefore, we investigated the relationship between serum 25-hydroxyvitamin D [25(OH)D] concentration and atherosclerotic disease risk factors in healthy Japanese adults. In the present cross-sectional study, 1,177 subjects (348 males and 829 females) aged 20-72 y living in Japan (34.7-35.0ºN) were evaluated for vitamin D status by measuring serum 25(OH)D concentration. Atherosclerotic disease risk factors were defined as the presence of two or more of the following three risk factors: high blood pressure, dyslipidemia, and hyperglycemia. The percentages of vitamin D deficient and insufficient subjects were 33% and 46% in males and 59% and 32% in females, respectively. Subjects with atherosclerotic disease risk factors were significantly older and had higher BMI than those without it in both sexes. Male subjects with atherosclerotic disease risk factors had significantly lower physical activity and serum 25(OH)D concentration than those without it. In a logistic regression analysis adjusted for confounding factors, serum 25(OH)D concentration showed a significant inverse association with risk factors of atherosclerotic disease in males (OR=0.951, 95%CI: 0.906-0.998), but not in females. A covariance structure analysis also suggested that serum 25(OH)D level has a direct association with risk factors of atherosclerotic disease. In conclusion, we have demonstrated that low serum 25(OH)D level is a significant factor for increased atherosclerotic disease risk factors in males.
The nature of China and Taiwan conflicting relations

Field: Social Sciences (Social Sciences)

The relations between China and Taiwan are widely considered "as one of the most sensitive issues," especially nowadays, in the era of U.S.-China strategic competition. For China, Taiwan's reunification is one of the key security issues. Within the scope of the new geopolitical dynamics in the existing world order, the goal of this paper is to address questions regarding China's-Taiwan policy as well as the U.S.-Taiwan policy, providing a comprehensive theoretical framework for understanding the nature of China and Taiwan tense relations. Starting from the premise that the changing policies related to China, Taiwan and the U.S., are related with the emerging global power shift, as well as with the redefinition of national interests of all the parties involved, by using qualitative data analysis, in this paper we will try to rethink how do changes in U.S.-China relationship and U.S.-Taiwan partnership may be primary triggers of the Taiwan Strait conflict scenario.
Parathyroid Carcinoma

Field: Medicine (Health Sciences)

The clinical presentation and genetic mutations associated with parathyroid cancer are reviewed. Surgery, other treatment modalities, and outcomes are discussed. This review contains 1 table and 19 references. Key Words: CDC73-related parathyroid carcinoma, denosumab, HRPT2 germline mutation, hyperparthyroidism-jaw tumor syndrome, parathyroid carcinoma
Study on Lidocaine Inhibiting Proliferation, Migration and Invasion of Breast Cancer Cells by Modulating the MicroRNA-495-3p/Fibroblast Growth Factor 9 Axis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

To investigate the mechanism of lidocaine in inhibiting proliferation, migration and invasion of breast cancer cells. Human breast cancer cell line Michigan Cancer Foundation-7 cells were treated with lidocaine. Cell proliferation was detected by 2,5-diphenyl-2H-tetrazolium bromide, cell migration and invasion was detected by Transwell, microRNA-495-3p expression was detected by quantitative reverse transcription polymerase chain reaction and fibroblast growth factor 9, cyclin D1, matrix metalloproteinase 2 and matrix metalloproteinase 9 protein expression were detected by western blot. Human breast cancer cell line Michigan Cancer Foundation-7 cells were transfected with microRNA-495-3p inhibitor or fibroblast growth factor 9 overexpression vector. The effects of silencing microRNA-495-3p or fibroblast growth factor 9 overexpression on proliferation, migration and invasion of human breast cancer cell line Michigan Cancer Foundation-7 cells and the expression of cyclin D1, matrix metalloproteinase 2 and matrix metalloproteinase 9 protein were detected by 2,5-diphenyl-2H-tetrazolium bromide, Transwell and western blot. The dual-luciferase reporter gene experiment confirmed the relationship between microRNA-495-3p and fibroblast growth factor 9 targeting. Lidocaine could inhibit the proliferation, migration and invasion of human breast cancer cell line Michigan Cancer Foundation-7 cells, promote the expression of microRNA- 495-3p and inhibit the expression of fibroblast growth factor 9 protein in human breast cancer cell line Michigan Cancer Foundation-7 cells. Silencing microRNA-495-3p expression or fibroblast growth factor 9 overexpression decreased the inhibitory effect of lidocaine on proliferation, migration and invasion of human breast cancer cell line Michigan Cancer Foundation-7 cells. MicroRNA-495-3p negatively regulated fibroblast growth factor 9 expression in human breast cancer cell line Michigan Cancer Foundation-7 cells. Silencing fibroblast growth factor 9 expression reversed the effect of microRNA-495-3p silencing on proliferation, migration and invasion of human breast cancer cell line Michigan Cancer Foundation-7 cells treated with lidocaine. Lidocaine inhibits the expression of fibroblast growth factor 9 by up-regulating microRNA-495-3p, thus inhibiting the proliferation, migration and invasion of breast cancer cells.
Models of Care That Meet the Standards of Crossing the Quality Chasm

Field: Health Professions (Health Sciences)

This article discusses the experience of 11 large health care systems in their attempts to improve quality of care. It focuses on four of the six performance characteristics outlined in Crossing the Quality Chasm, the second report of the Institute of Medicine (IOM): improved effectiveness, renewed focus on patients, timeliness and convenience, and efficiency. For example, all of the systems have been making substantial investments in clinical information systems and are beginning to see some of the benefits, including improved quality and coordination of care. Although the Institute of Medicine's report found that major reform of the U.S. health care system is needed, it is encouraging that a number of organizations are putting forth a significant effort toward improving performance and are making progress in the achievement of their improvement goals.
Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions

Field: Neuroscience (Life Sciences)

Inflammation is a hallmark mechanism of ischemic stroke-induced brain injury. Recent studies have shown that an intracellular multimeric protein complex known as an inflammasome is a key factor for inducing an inflammatory response, and apoptotic and pyroptotic cell death in ischemic stroke. Inflammasome assembly leads to the activation of pro-inflammatory caspases, and the maturation and secretion of pro-inflammatory cytokines IL-1β and IL-18. While the role of inflammasomes in ischemic stroke-induced neuronal death, and microglial activation and cell death have been established, little is known about the role of inflammasomes in astrocytes under ischemic conditions. In this study, we investigated the expression and activation of inflammasome components in protoplasmic and fibrous astrocytes under ischemic conditions. We found that both protoplasmic and fibrous astrocytes expressed a differential increase in inflammasome protein components, and that their activation promoted maturation of IL-1β and IL-18, and secretion of IL-1β, as well as initiating apoptotic and pyroptotic cell death. Pharmacological inhibition of caspase-1 decreased expression of cleaved caspase-1 and production of mature IL-1β, and protected against inflammasome-mediated apoptotic and pyroptotic cell death. Overall, this study provides novel insights into the role of inflammasome signaling in astrocytes under ischemic conditions.
The effect of doxazosin on endothelial function in non diabetic hypertensive patients with the metabolic syndrome. A comparison with chlortalidone

Field: Medicine (Health Sciences)

Improvement of endothelial function is an important end-point in the subset of hypertensive patients with metabolic syndrome, the phenotype of an underlying insulin resistance which associates with endothelial dysfunction. To evaluate whether alpha-1 antagonists ameliorate endothelial function in that specific patient subset, we evaluated the effect of doxazosin (DOXA), as compared with chlortalidone (CHLOR), a thiazide-like compound, in hypertensive patients with the metabolic syndrome. 25 (49±7 yrs, 23M/2F) untreated, non diabetic (plasma glucose: 103±12 mg/dl) mild hypertensive pts (152±23/100±13 mmHg) with high TG (median: 236, range: 177–928 mg/dl), low HDL cholesterol (37±5 mg/dl) and high fasting insulin levels (19±10mU/ml) were randomly assigned to 3 month-treatment with either DOXA (n=12) or CHLOR (n=13) at doses titrated (mean daily doses DOXA: 5.5±2, CHLOR: 35±9 mg/die) to achieve normotension. Endothelial function was assessed by measuring 1. Albumin transcapillary escape rate (TERalb, the 1-hr decay rate of 125I-albumin,5–7mC ev,), a measure of albumin permeation through systemic capillaries, 2. Forearm blood flow (FBF, strain-gauge plethysmography) responses (% changes from baseline) to graded infusion of intraarterial acetylcholine (ACH, 7.5, 15 e 30 mg/min, 5 minutes each), an endothelial-mediated vasodilator 3. Reactive hyperemia (RH) to a 10 min forearm arterial occlusion. As compared with pretreatment values, TERalb was reduced (p=0.02) to a similar extent by both treatment (DOXA:11.0±2.4 vs 9.5±1.9; CHLOR: 10.7±1.8 vs 9.0±1.8 %/hr). ACH-mediated forearm vasodilation increased during both DOXA (pretreatment: 7.5:133±40%, 15: 238±79%, 30μg/min:360±161%; DOXA: 7.5:202±80%, 15:294±94%, 30μg/min:427±122%,p=0.02) and CHLOR (pretreatment: 7.5:113±73%, 15:195±92%, 30μg/min:262±106%; CHLOR: 7.5:194±137%, 15:292±166%, 30μg/min:381±131%, p=0.03). RH behaved similarly (DOXA: from 37.8±7.3 at pretreatment to 44.8±6.6, p=0.008; CHLOR: from 34.0±8 to 41.1±7.7 ml/min/100 ml, p=0.002). Long-term treatment with either DOXA, an alpha-1 antagonist, or CHLOR, a thiazide-like diuretic agent, reduces systemic capillary permeability and augments endothelial-mediated vasomotor function in non diabetic, hypertensive patients with the metabolic syndrome.
A process for the rational crystallization of biological macromolecules

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

A crystallization method, a microplate and an instrument were developed, allowing for the first time the application of an objective and contact-free evaluation of clear drops as well as a robust evaluation of precipitates within crystallization experiments.Laser light scattering and polarization microscopy are used for an optical characterization of solute or precipitated proteins.Both approaches form the basis of an automated, rational and adaptive crystallization process.The implementation of well-documented and unbiased information derived from thermodynamic solution parameters such as the second virial coefficient (crystallization window) and the early and objective identification of microcrystalline precipitates will probably cause a paradigm shift in the way protein crystallization is approached.The new method is automated and performed using a new microplate and 200 nL droplets of the protein solution.
Methacrylic Esters of Glucose and Other Carbohydrates1

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethacrylic Esters of Glucose and Other Carbohydrates1R. H. Treadway and E. YanovskyCite this: J. Am. Chem. Soc. 1945, 67, 6, 1038–1039Publication Date (Print):June 1, 1945Publication History Published online1 May 2002Published inissue 1 June 1945https://pubs.acs.org/doi/10.1021/ja01222a508https://doi.org/10.1021/ja01222a508research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and characterization of polyaniline coated gold nanocomposites

Field: Materials Science (Physical Sciences)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Siti Nurzulaiha Mohd Zuber, Dzaraini Kamarun, Hamizah Zaki, Mohamad Shukri Kamarudin, Sabu Thomas, Nandakumar Kalarikkal; Synthesis and characterization of polyaniline coated gold nanocomposites. AIP Conference Proceedings 28 August 2015; 1674 (1): 020010. https://doi.org/10.1063/1.4928827 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Analysis of Modular Multilevel Converter Based Solid State Transformer Implementing Hybrid Control

Field: Engineering (Physical Sciences)

A Solid State Transformer (SST) consists of a high-frequency transformer and power electronic converters. It is relatively a complex system. It requires control in many stages. The control methods vary from topology to topology. In this paper, Modular Multilevel Converter (MMC) topology is used in converter stage. To control MMC, a hybrid control is implemented consisting of a modified sorting algorithm and model predictive control. Using the proposed algorithm, the performance of the system under different grid disturbances has been analyzed.
Fertility response of anestrous buffaloes to eCG2-Modified or Norgestomet plus eCG6- Modified-GnRH-based ovsync protocols during the breeding season.

Field: Veterinary (Health Sciences)

Objective:The aim of the current study was to evaluate the fertility response of anestrous buffaloes and associated follicular growth and hormonal profiles to eCG-Modified (eCG2-ovsync) or eCG plus Norgestomet ear implant-Modified (Norgestomet-eCG6-ovsync) GnRH-Based ovsync protocols.Methods: Buffaloes (n=42) were randomly allocated into three treatment protocols: Basic-ovsync, Norgestomet-eCG6-ovsync and eCG2-ovsync (14 each).Each buffalo-cow in the Basic-ovsync protocol received two GnRH agonist injections on Days 0 (GnRHa1) and Day 9 (GnRHa2) and an injection of PGF2α on Day 7 with TAI at 16 h after GnRHa2 injection.Buffaloes in Norgestomet eCG6-ovsync (n=14) received the same treatment as Basic -ovsync plus IM injection of 250 mg of long-lasting progesterone and S/C insertion of Norgestomet ear implant in the ear Conca on Day 0 and an injection of 500 IU eCG on Day 6. Buffaloes in eCG2-ovsync received the same treatment of Basic ovsync in addition to an injection of 1000 IU eCG on Day 2. Simultaneous transrectal ultrasonography (TUS) and blood sampling were performed on Days -10, 0, 7, 9 and 10 as well as on post-TAI Days 11 and 22. Results: The largest follicle diameter (LFD) was significantly larger (p<0.05) in eventually diagnosed pregnant (EDP) than in eventually diagnosed non-pregnant (EDnP) buffaloes in all treatment protocols on Day 9.The serum progesterone (P4) concentration was significantly higher (p<0.05) in either EDP or EDnP buffaloes in Noegestomet eCG6-ovysync compared with other protocols on Day 7.There was a highly significant (r=0.74,P<0.01) positive correlations between corpus luteum volume (CLV) and LFD in EDP buffaloes.Conclusions: It is concluded that modifying Basic-ovsync via P4 supplementation by injection of long-lasting P4 on Day 0 and insertion of Norgestomet ear implant from day 0 to day 7 plus an injection of eCG on Day 6 improve the fertility response in true anestrus in buffaloes.
Effectiveness of climate resilient agricultural technologies as perceived by farmers in Nalgonda District of Telangana State

Field: Agricultural and Biological Sciences (Life Sciences)

The detrimental effects of climate change on Indian Agriculture are inevitable and agricultural professionals are bestowed with the responsibility of making it less vulnerable to climate change. In the present context, the following study was undertaken in Nalgonda district of Telangana State in India where three villages namely Nandyala Gudem, Boring thanda and Kotha thanda of Athmakur (S) Mandal were selected purposively as the National Innovations in Climate Resilient Agriculture (NICRA) interventions are being implemented in these villages to impart climate resilience. A sample size of 40 farmers was selected at random from each village thus comprising a total sample size of 120. An index was developed to assess the perceived effectiveness of Climate Resilient Agricultural (CRA) technologies by the farmers using five indicators viz., Adoption of CRA technologies, Exposure, Sensitivity, Adaptive capacity and Sustainability. The results revealed that the majority of respondents belonged to the category of a high level of adoption of CRA technologies (39.17%), medium level of exposure (30.84%), low sensitivity (30%), medium adaptive capacity (31.67%) and high sustainability (36.67%) of CRA technologies as perceived by the farmers. The overall effectiveness of CRA technologies as perceived by the farmers was found to be medium (35.83%) for a majority of the farmers followed by very highly effective (29.17%).
Static and dynamic lattice changes induced by hydrogen adsorption on NiAl(110)

Field: Physics and Astronomy (Physical Sciences)

Static and dynamic changes induced by adsorption of atomic hydrogen on the\nNiAl(110) lattice at 130 K have been examined as a function of adsorbate\ncoverage. Adsorbed hydrogen exists in three distinct phases. At low coverages\nthe hydrogen is itinerant because of quantum tunneling between sites and\nexhibits no observable vibrational modes. Between 0.4 ML and 0.6 ML, substrate\nmediated interactions produce an ordered superstructure with c(2x2) symmetry,\nand at higher coverages, hydrogen exists as a disordered lattice gas. This\npicture of how hydrogen interacts with NiAl(110) is developed from our data and\ncompared to current theoretical predictions.\n