jimnoneill/paper-to-field-training huggingface dataset:
Ectopic expression of the Arabidopsis transcriptional activator Athb-1 alters leaf cell fate in tobacco.

Field: Agricultural and Biological Sciences (Life Sciences)

The Arabidopsis thaliana Athb-1 is a homeobox gene of unknown function. By analogy with homeobox genes of other organisms, its gene product, Athb-1, is most likely a transcription factor involved in developmental processes. We constructed a series of Athb-1-derived genes to examine the roles of Athb-1 in transcriptional regulation and plant development. Athb-1 was found to transactivate a promoter linked to a specific DNA binding site by transient expression assays. In transgenic tobacco plants, overexpression of Athb-1 or its chimeric derivatives with heterologous transactivating domains of the yeast transcription factor GAL4 or herpes simplex virus transcription factor VP16 conferred deetiolated phenotypes in the dark, including cotyledon expansion, true leaf development, and an inhibition of hypocotyl elongation. Expression of Athb-1 or the two chimeric derivatives also affected the development of palisade parenchyma under normal growth conditions, resulting in light green sectors in leaves and cotyledons, whereas other organs in the transgenic plants remained normal. Both developmental phenotypes were induced by glucocorticoid in transgenic plants expressing a chimeric transcription factor comprising the Athb-1 DNA binding domain, the VP16 transactivating domain, and the glucocorticoid receptor domain. Plants with severe inducible phenotypes showed additional abnormality in cotyledon expansion. Our results suggest that Athb-1 is a transcription activator involved in leaf development.
Tissue expression and urinary excretion of liver-type fatty acid binding protein in older dogs with or without early signs of chronic kidney disease

Field: Veterinary (Health Sciences)

Liver-type fatty acid-binding protein (L-FABP) is expressed by several tissues, plays a role in fatty acid metabolism, and has antioxidant effects. Its renal expression is upregulated by stress. Urinary L-FABP (uL-FABP) is a promising kidney biomarker in people for detection of early acute and chronic kidney disease (CKD) and as a marker for progression in patients with glomerulonephritis. However, data on canine uL-FABP are currently limited. This prospective study was designed to examine canine tissue expression of L-FABP and to validate an ELISA to quantify uL-FABP in older dogs with or without early signs of CKD. Tissues of 4 recently euthanized dogs and 117 urine samples of 73 client-owned older dogs undergoing health screening were evaluated in the study. Immunohistochemistry was performed on kidney and liver tissues. Analytical validation of a commercially available ELISA for measurement of L-FABP in canine urine was performed (limit of detection, imprecision, specificity). The ELISA was used to measure L-FABP in stored urine samples from a cohort of older dogs. Dogs were found to express L-FABP, mostly in proximal tubular epithelial cells and in the periportal hepatocytes of the liver. Assay validation revealed poor sensitivity and imprecision for measurement of canine uL-FABP. Of the 117 urine samples analyzed, 98 were below the limit of detection (LOD; 7.30 ng/mL) and a further 5 were below the limit of quantification (LOQ; 16.20 ng/mL). The proximal tubules of dog kidneys express L-FABP, but the value of uL-FABP as tubular marker in older dogs warrants further study.
TROPES OF DISABILITIES, MOTIFS OF SURVIVAL IN JOHN MAXWELL COETZEE’S AGE OF IRON AND DISGRACE

Field: Arts and Humanities (Social Sciences)

Readers and critics of South African Literature, until 1990, are very familiar with the \nliterature of that country which gave due attention to the malaises of chronic racial abuses \nand other vices that prevailed while the apartheid system subsisted. With the official closure \nof that regime in 1994, the engagement naturally diverts to the survival of a nation that \nwas coming out of decades of social injuries and strife. This paper, in an intertextual study \nof Age of Iron (1990) and Disgrace (1999), picks out John Maxwell Coetzee as one of the \nwriters of South Africa descent that has responded to the experiences of the nation in the \naftermath of the apartheid experience. The paper interrogates Coetzee’s uses of tropes and \nmotifs in his concern about the survival of his nation in the nascent post-apartheid era as \nreflected in his mirroring of the crimes of apartheid and its ramified consequences. After \nisolating the diverse tropes deployed by the novelist to objectify the inhuman experience \nand the consequent personal and national traumas of that era, the paper concludes by \naggregating the tenets of acceptance, forgiveness, and atonement as core indispensable \nvalues for a nation in search of healing
Searching for a correlation between cosmic-ray sources above 1019eV and large scale structure

Field: Physics and Astronomy (Physical Sciences)

We study the anisotropy signature which is expected if the sources of ultra high energy, >10^{19} eV, cosmic-rays (UHECRs) are extragalactic and trace the large scale distribution of luminous matter. Using the PSCz galaxy catalog as a tracer of the large scale structure (LSS), we derive the expected all sky angular distribution of the UHECR intensity. We define a statistic, that measures the correlation between the predicted and observed UHECR arrival direction distributions, and show that it is more sensitive to the expected anisotropy signature than the power spectrum and the two point correlation function. The distribution of the correlation statistic is not sensitive to the unknown redshift evolution of UHECR source density and to the unknown strength and structure of inter-galactic magnetic fields. We show, using this statistic, that recently published >5.7x10^{19} eV Auger data are inconsistent with isotropy at ~98% CL, and consistent with a source distribution that traces LSS, with some preference to a source distribution that is biased with respect to the galaxy distribution. The anisotropy signature should be detectable also at lower energy, >4x10^{19} eV. A few fold increase of the Auger exposure is likely to increase the significance to >99% CL, but not to >99.9% CL (unless the UHECR source density is comparable or larger than that of galaxies). In order to distinguish between different bias models, the systematic uncertainty in the absolute energy calibration of the experiments should be reduced to well below the current ~25%.
Geological and geochemical characteristics of the Mengxi Cu-Mo deposit and its constraint to tectonic setting of the Qiongheba magmatic arc in eastern Junggar, Xinjiang.

Field: Earth and Planetary Sciences (Physical Sciences)

The Mengxi Cu-Mo deposit located north to the contact zone of Qiongheba granite batholith at the eastern segment of Beitashan-Qiongheba arc, eastern Junggar, is characterized by strong alternation, development of fracture-filled veins, and vertical zoning of veins with various mineral composition, and is kind of porphyritic Cu-Mo deposit strong affected by fault stnjctures in the ore district. Diorite porphyries and feldspar porphyries are ore-forming porphyry in the Mengxi Cu-Mo deposit. Granite in the Qiongheba area are calc-alkaline, and characterized by high Pb, K, Sr, U, Th and Zr, low Rb, Nb, Y, Ta, Yb and Ti, enriched LREE with (La/Yb)_N value from 3. 1 to 15.5. All the 22 analyzed intrusive samples have plots in the VAG (volcanic arc granite) domain in diagrams of Rb-Y + Nb, Nb-Y, Rb-Ta + Yb and Ta-Yb, and similar trace element and REE spiders with that of continental arc volcanic in Andes. These granite were production of continental arc magmatism with a composition containing component from the upper, middle and lower continental crust and equal to the average of continental arc volcanic rocks in Andes. Result of Re-Os dating shows that both the molybdenite and Cu-Mo deposit in the Mengxi area were formed at about 411 Ma BP, the diorite porphyries and feldspar porphyries in the Mengxi ore district and granite in the Qiongheba area were possible formed at latest Silurian- earlist Devonian. This indicates that Yemaquan-Beitashan- Qiongheba porphyries and porphyry copper mineralization belt is most likely the western extending of the the Oyu Tolgoi Silurian-Devonian porphyry copper mineralization belt. The granite belt in the Qiongheba area, as a part of Paleozoic continental arc magmatic belt, is a potential target for porphyritic Cu deposit.
[Effect of exogenous zinc addition on cell protective enzyme activities in the fruit bodies of Lentinus giganteus].

Field: Agricultural and Biological Sciences (Life Sciences)

High Zn concentration caused the increase of MDA contents and the decrease of SOD, POD and CAT activities in the fruit body of L. giganteus. It will destroy the protective enzyme system, cause the accumulation of free radicals and thus intensify membrane lipid peroxidation. Appropriate Zn concentration improved the protective enzyme activities, and lightened the harm of membrane from lipid peroxidation.
Güvenli cinsellik ve HIV/AIDS Riski: YouTube videolarının güvenilirlik, kalite ve kullanılabilirlik analizi

Field: Health Professions (Health Sciences)

OBJECTIVE: It aims to evaluate the information content quality and usefulness of videos on HIV/AIDS risk and sexual behavior available on YouTubeTM as an information source. MATERIAL and METHODS: A search was done for videos uploaded on YouTubeTM about HIV/AIDS using the keywords “HIV/AIDS risk and sexual behavior”. Three researchers independently evaluated the videos’ reliability (DISCERN), quality, and usefulness. For each keyword, 234 videos from the first 10 years and 107 pages were included in the research, in order of relevance. Twenty-five videos that met the research criteria were included in the review. RESULTS: 80.0% of the sample emphasize condom use, and 60.0% emphasize alcohol and drug use before sexual intercourse. Quality was determined as (GQS 2.9±1.0), DISCERN reliability score (3.4±1.1). It is seen that the average video duration, GQS and Discern scores of videos with good quality information content are numerically higher than those of videos with medium and poor quality information content. Still, there is no relationship between them (p>0.05). CONCLUSION: YouTube is a source of information about HIV/AIDS of variable quality, with a large audience and the potential to influence patients’ knowledge and behavior. Physicians, healthcare professionals, and professional organizations need to be aware of this evolving technology to raise awareness about HIV/AIDS and empower patients to distinguish useful information from misleading information. Keywords: HIV/AIDS, sexuality, sexual behavior, protection, YouTube
Large-scale Chinese FSTT Database for Finite Element Modeling

Field: Engineering (Physical Sciences)

Facial soft tissue thickness (FSTT), together with the representive 3D headform, is of great importance to develop finite element models (FEM) for virtual simulation of head worn products to achieve safety as well as comfort experience. The FEM is a widely used approach for numerically solving differential equations arising in engineering and mathematical modeling, which can be used to determine the distribution stresses and deformations between the wearables and the human body, as well as providing strong support for ergonomics product design. Although several countries around the world have established FSTT databases, to the best of our knowledge, no large-scale dataset or analysis has ever been reported in China.In this paper, FSTT was measured at 17 anthropological landmarks on heads using computerized tomography (CT) of 1174 Chinese adults aged between 18 to 90, which were collected and processed from the First Hospital of Changsha in China. All landmarks were located in 17 craniofacial anthropological regions. For each landmark, basic descriptive statistics were calculated. FSTT values classified by gender and age groups were analyzed to assess the variation in FSTT within these categories.The results indicate that certain FSTT values are correlated with age and gender categories. For example, it was found that men generally have higher FSTT than women at certain landmarks, while regions around the temporal bone show opposite results. For age categories, quite a few landmarks show a general decrease with age.
Incorporation of crosslinking agents into poly(vinyl phosphonic acid) as a route to glass–polyalkenoate cements of improved compressive strength

Field: Chemical Engineering (Physical Sciences)

A method for incorporating potential crosslinking agents into poly(vinyl phosphonic acid)(PVPA) is described. Polymers with increased relative molar mass have been synthesized and used to fabricate experimental PVPAbased dental cements of improved compressive strength. The presence of these crosslinking agents was found to make no significant difference to the working and setting times or overall handling characteristics of these cements.
The Zen of physician initiatives.

Field: Health Professions (Health Sciences)

Many physicians today feel ravaged by the brutal speed with which change has been occurring. They see the beliefs and practices of a lifetime being abandoned and replaced by the flavor of the month, management du jour. But if you are willing and able to take the brave step of approaching your physicians without an agenda, meeting with them to listen to their concerns, and can also avoid hanging a lightning-rod label on every bright new idea that comes out of the sessions, you'll be on the way to effective new management. This new style is a "Zen" approach (but don't give it that label) that lets real collaboration come into the place that is supposed to be all about healing--the health care organization. From "never call it anything" to "stay with them until they get it," ideas on how to be a Zen manager are presented, with the ultimate goal of truly partnering with physicians and infusing them with a desire to move beyond the frustration and disenchantment they are feeling.
The Impact of Inter-Organizational Relationships and Export Market Orientation on Performance

Field: Business, Management and Accounting (Social Sciences)

Based on relational view, this study aims to investigate whether the relationship between inter-organizational relationship and export market orientation to promote the export performance and to examine whether internationalization moderate the relationship between export market orientation and export performance. A survey was adopted in Taiwan using the top 1,000 manufacturing firm and 500 machinery manufacturers database. A total of 232 effective samples were analyzed. The research findings indicated that (1) Social capital has positive impact on export market orientation. (2) Export market orientation has positive impact on export performance. Finally, implications of the present study and directions for future research are discussed.
Observational Pilot Using a Data to Care Intervention Strategy to Promote HCV Re-engagement and Cure for Persons with HIV/HCV Co-infection who are Out of Care

Field: Health Professions (Health Sciences)

Abstract

Background: With Direct Acting Antivirals for Hepatitis C virus (HCV), cure is possible in >95% including those with HIV/HCV co-infection. Achieving strategic targets for cure requires addressing barriers including suboptimal care engagement. We adapted Data to Care (D2C), a public health strategy designed to identify and link persons out of care (OOC) for HIV, for persons with HIV/HCV co-infection untreated for HCV. Methods: In partnership with Connecticut Department of Public Health (DPH), persons OOC for HIV (defined as no HIV surveillance laboratory tests from 10/1/2018-10/1/2019) were matched to a list of persons co-infected with HIV/HCV (through 12/31/2019). We used a three-phase follow-up approach (pre-work, case conferencing, and Disease Intervention Specialist (DIS) follow-up) to track outreach outcomes and re-engagement/HCV cure success. Results: There were 90 HIV/HCV co-infected persons who were OOC for HIV. The pre-work and case conferencing phases determined that 33 (36.7%) had previous HCV cure or were in treatment. There were 41 eligible for DIS-follow-up of which 21 (51%) were successfully contacted and 7 (33%) successfully re-engaged (kept appointment with HCV provider). No new HCV treatment initiations were recorded. Conclusions: Using a D2C approach, we identified and conducted outreach to persons who were OOC for HIV to promote HCV treatment. This approach resulted in intensive data clean-up and outreach efforts which produced modest re-engagement and no HCV treatment initiations. Future studies should develop alternative and complementary interventions to promote effective re-engagement and HCV treatment.
Group of Seven (G7) Countries Stock Markets Returns during COVID-19 Outbreak: An ARDL-MIDAS Approach

Field: Economics, Econometrics and Finance (Social Sciences)

Abstract: The impact of the coronavirus (COVID-19) outbreak is visible in the global stock market. This study intents to investigate this issue for the Group of Seven countries (G7) using an Autoregressive Distributed Lags-Mixed Data Sampling (ARDL-MIDAS). The model allows to see how weekly stock indices return of G7 countries respond to the daily COVID-19 cases growth. The findings indicate that COVID-19 has a varied impact on each of the G7 countries’ stock indices due to measures taken by the government to curb COVID-19 spread and stimulus package introduction, as well as the development of vaccines. Keywords: Group of Seven Countries, Stock Returns, COVID-19, Mixed Frequency, ARDL-MIDAS
1144 – Crimes And Mental Elderly Patients In Psychiatric Hospital Of Razi In Tunisia

Field: Medicine (Health Sciences)

Introduction Few scientific studies have been devoted to the study of crime among the mentally ill elderly, however, all the studies agree on the importance of recognizing risk factors associated with passage to forensic action in elderly patients. Aims The objectives of our work are to clarify the sociodemographic, clinical and forensic characteristic of mental elderly patients who commit forensic acts. Methodologie Our work has focused on all patients older than 60 years hospitalized under the mode of office between 1995 and 2012 in the service of forensic Razi hospital according to article 29 of the law n° 92–83 of the third of August 1992 as amended by the law 2004-40 of 3 May 2004, following a non-legal place due to insanity within the meaning of the 38 article of the Tunisian Penal Code. Results Our study included 25 patients, their ages ranged between 60 and 90 years. They mostly had a low socio-economic level (64%), a low educational level (48%) and a marital status of married (64%). All patients had a neuropsychiatric disease: schizophrenia and other psychotic disorders in 48% of cases, dementia and Delirium nonspecific in 32% of cases, mood disorder in 16% of cases and mental retardation in 4% of cases. The medico-legal act was murder or attempted murder in 40% of cases, sexual crimes in 16% of cases, aggression against property in 16%, violence against people in 8% of cases and different offenses in the remaining cases.
[Regulation mechanisms of the endoplasmic cytochrome P-450 systems of the liver].

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Regulation mechanisms of the cytochrome P-450 dependent monooxygenase from the hepatic endoplasmic reticulum at 3 different integrational levels are discussed. At the molecular level the activity of the system is regulated by a substrate dependent shift of an equilibrium of cytochrome P-450 spin conformers in favour of the high spin component. A correlation between the extent of the spin shift, the reduction rate and the substrate turnover has been evidenced. The regulation at the membrane level is based on interactions between the 3 essential components of the system: cytochrome P-450, reductase and lipid. The formation of the cytochrome P-450-reductase-complex necessary for oxygen activation by transfer of electrons is dependent on the charge of the phospholipids. The binding constant of the donor-acceptor complex increases with the acidity of the phospholipid head group, thus enhancing the velocity of the electron transfer.
Perancangan Media Visual Event Promosi Museum Layang-Layang Indonesia

Field: Arts and Humanities (Social Sciences)

Museum Layang-Layang Indonesia merupakan satu-satunya museum layang -layang di Indonesia yang terletak di jalan H. Kamang no.38 Pondok Labu, Jakarta Selatan. Museum yang didirikan oleh Ibu Endang W. Puspoyono pada tanggal 21 Maret 2003 ini menyimpan ratusan koleksi layang-layang yang bervariasi dari segi bentuk dan ukuran serta berasal dari seluruh pelosok nusantara dan mancanegara. Berdasarkan hasil kuesioner yang dibagikan, mayoritas masyarakat tidak pernah mengunjungi museum ini. Beberapa faktor yang menyebabkan kurangnya pengunjung adalah kurangnya informasi
dan promosi yang dilakukan oleh pihak museum, sehingga sedikit masyarakat yang mengetahui akan keberadaan Museum Layang-Layang Indonesia didukung dengan lokasinya yang tidak strategis. Sangat disayangkan mengingat bahwa sesungguhnya museum ini berpotensi besar untuk dijadikan tempat wisata yang menarik dan menghibur untuk masyarakat luas, khususnya pelajar Sekolah Menengah Pertama.
Diperlukan perancangan media visual event promosi yang tepat dan sesuai dengan target audience untuk membuat Museum Layang-Layang Indonesia lebih dikenal masyarakat, khususnya yang tinggal di kota Jakarta. Perancangan event promosi yang dilakukan diharapkan dapat menarik minat masyarakat luas, khususnya pelajar Sekolah Menengah Pertama, agar mereka datang ke Museum Layang-Layang Indonesia.
Numerical Investigation on Proppant–Water Mixture Transport in Slot under High Reynolds Number Conditions

Field: Engineering (Physical Sciences)

Water hydraulic fracturing involves pumping low viscosity fluid and proppant mixture into the artificial fracture under a high pumping rate. In that high Reynolds number conditions (HRNCs, Re > 2000), the turbulence effect is one of the key factors affecting proppant transportation and placement. In this paper, a Eulerian multiphase model was used to simulate the proppant particle transport in a parallel slot under HRNCs. Turbulence effects in high pumping rates and frictional stress among the proppant particles were taken into consideration, and the Johnson-Jackson wall boundary conditions were used to describe the particle-wall interaction. The numerical simulation result was validated with laboratory-scale slot experiment results. The simulation results demonstrate that the pattern of the proppant bank is significantly affected by the vortex near the wellbore, and the whole proppant transport process can be divided into four stages under HRNCs. Furthermore, the proppant placement structure and the equilibrium height of proppant dune under HRNCs are comprehensively discussed by a parametrical study, including injection position, velocity, proppant density, concentration, and diameter. As the injection position changes from the lower one to the top one, the unpropped area near the entrance decrease by 7.1 times, and the equilibrium height for the primary dune increase by 5.3%. As the velocity of the slurry jet increases from 2 m/s to 5 m/s (Re = 2000–5000), the vortex becomes stronger, so the non-propped area near the inlet increase by 5.3 times, and the equilibrium height decrease by 5.2%. The change of proppant properties does not significantly change the vortex; however, the equilibrium height is affected by the high-speed flush. Thus, the conventional equilibrium height prediction correlation is not suitable for the HRNCs. Therefore, a modified bi-power law prediction correlation was proposed based on the simulation data, which can be used to accurately predict the equilibrium height of the proppant bank under HRNCs (mean deviation = 3.8%).