jimnoneill/paper-to-field-training huggingface dataset:
Reno productive activity of Ipomoea digitata in gentamicin induced kidney dysfunction

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Kidneys endowed with million units termed as Ã¢â‚¬Å“nephronsÃ¢â‚¬Â that act as natural sieves. The kidneys provide the final common pathway for the excretion of many drugs and their metabolites and therefore are frequently subjected to high concentrations of potentially toxic substances. Administration of several antibiotics like Gentamicin causes kidney dysfunction. Rats treated with Gentamicin developed significant kidney dysfunction was observed from increased level of urea, creatinine, sodium and decreased level of protein, potassium and non enzymatic antioxidants such as vitamin C and vitamin E. The plant, Ipomoea digitata is found to have nephroprotective activity. \n\n--------------------------------------------------------------------------------------------------------\n*Department of Biochemistry and Chemistry, Faculty of Science, PRIST University, Vallam, Tanjavur Ã¢â‚¬â€œ 613 403, Tamilnadu, India\n**Department of Zoology, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India\n1Corresponding author, Email: pragmatist999@yahoo.co.in\nCite This Article As: A. Kalaiselvan, T. Anand and M. Soundararajan.Reno productive activity of Ipomoea digitata in gentamicin induced kidney dysfunction. J. Ecobiotechnol. 2(2): 57-62.
Optimizing Virtual Communities in Tourism to Facilitate Development of Small and Medium-Sized Enterprises

Field: Business, Management and Accounting (Social Sciences)

The chapter presents the essence of online/virtual travel communities and examines their current significance for SMEs. It presents types and characteristics as well as the most popular virtual travel SME communities and discusses ways of optimizing the development of SMEs by applying a strategy of virtual communities by selected hospitality SMEs. An eight step strategy to implement virtual travel communities by SMEs is elaborated. One of the main findings of the author is that virtual travel communities can be very useful for optimizing the development of SMEs by supporting all the stages in the decision-making process, focusing on pre-planning, making the decision and after the tourist and business visit stage. In order to understand how virtual travel community can optimize the development of SMEs, the author discusses tools for measuring the effectiveness of social media. Both future research directions and a conclusion are outlined.
Constitutional Majoritarianism against Popular “Regulation” in the Federalist

Field: Arts and Humanities (Social Sciences)

In this essay, I make the interpretive claim that we cannot properly understand the Federalist without appreciating the extent to which the papers mount a sustained rejection of extra-constitutional democracy—practices in which people aim to assert authority over the terms of common life in ways that are not sanctioned by existing laws. I survey such practices, which were common in America before and after the Revolution. I argue that there is continuity between Publius’s justification for rejecting extra-constitutional democracy and his justification for his preferred system against constitutional alternatives. Adequate analysis and evaluation of the Federalist’s arguments about faction, representation, and institutional design require attention to the double duty the arguments play against constitutional and extra-constitutional opposition. This interpretive argument supports several analytic and evaluative conclusions. First, we must distinguish a new form of “non-hierarchical dualist” constitutionalism, according to which irregular democratic activity need not be limited to extraordinary “constitutional moments” or revolutions. Second, the politically egalitarian character of procedures depends not on the procedures alone, but how the maintenance of such procedures limits other forms of democratic practice. Third, the argument suggests a novel defense of “uncivil” disobedient politics: one grounded not in contributions to democratic deliberation, but in the entitlements of citizens to direct assertions of authority over common life.
Development of the green policy strategies of enterprises: а decent work

Field: Business, Management and Accounting (Social Sciences)

This research examines the symbiotic relationship between the creation of green jobs within enterprises, economic growth, and the consequential reduction in CO2 emissions. It delves into the multifaceted advantages derived from integrating sustainable employment practices within businesses, emphasising their substantial contribution to fostering economic prosperity while concurrently mitigating adverse CO2 emissions. The main goals of this article are as follows: to study the experience of developed countries regarding the costs of their sustainable development strategies and the effects that have been achieved; generalise the main tools for ensuring decent work on the example of large companies, evaluate the relationship between reducing nitrogen dioxide emissions and providing green jobs. A comparison of financial instruments for maintaining green workplaces at enterprises in developed countries (USA, Norway, China, Germany, Sweden, and Poland) has been made. CO2 emissions reduction strategies, expenditure, funding, financing, and green jobs by countries have been analyzed. By investing in green initiatives and restructuring operational frameworks to prioritise sustainability, enterprises actively mitigate their carbon footprint, ultimately contributing to a greener and more environmentally conscious business landscape. This comprehensive study explores recent advancements in green job creation and renewable energy development in different countries of the world. The strategies of reducing CO₂ emissions by such companies as IKEA, Google, Unilever, and Tesla show not only positively impact the environment but can also be profitable for their businesses and guarantee decent work for their employees.
COVID-19 - pandemic effect on Human Papilloma Virus Vaccination of eighth grade students in Croatia

Field: Health Professions (Health Sciences)

Abstract Issue/problem Vaccination at the time of the Covid-19 pandemic is a challenge for vaccinators. The consequences of not vaccinating against human papilloma virus (HPV) of youngs for their future reproductive health are far-reaching. In Croatia, HPV vaccination is voluntary and free for all school children and students. Description of the problem Rate of HPV vaccination in eighth grade students before the epidemic school year 2018/19, at the onset of the epidemic 2019/20 and 2020/21 in the midst of the epidemic, Croatia in the city of Koprivnica and 11 municipalities in the Koprivničko-križevačka County. The research included 1530 children of eighth grade during three school years in the city of Koprivnica and 11municipalities. Data were collected by the School Health Service. Before the panidemic, vaccinations took place at school, and during the epidemic exclusively in school medicine practices. Completely vaccinated are considered those vaccinated with two or three doses depending the student age. Results Fully vaccinated students 2018/2019 is 54.2% (277/511), urban area 48.0% (133/277) and rural area 61.5% (144/234). 2019/2020 62.0% (330/532) of students were vaccinated, urban area 56.3% (160/284) and rural area 68.6% (170/248). Coverage of girls with full vaccination 2018/2019 is 63.4% and boys 46.6%. In 2019/2020 71.8% girls and 52.3% boys were fully vaccinated. In 2020/2021 the first dose received 53.4% (260/487), girls 65.3% and boys 43.4%. The second dose did not received in 2018/2019 5.2% students and 2019/2020 8.8%. The main reason in the rural area is the distance from school clinics and the inability to vaccinate children at school. Lessons In the school year 2019/2020 there was an increase in vaccination compared to 2018/2019 of 7.8%, despite difficult conditions. Key messages Unexpectedly during the epidemic the response to vaccination increased. HPV vaccination should remain a priority in adolescent health protection.
Therapeutic potential of the epidermal growth factor receptor transactivation in hypertension: a convergent signaling pathway of vascular tone, oxidative stress, and hypertrophic growth downstream of vasoactive G-protein-coupled receptors?This paper is one of a selection of papers published in this Special Issue, entitled Young Investigators' Forum.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The concurrence of enhanced vascular tone, oxidative stress, and hypertrophic growth is a hallmark of hypertension, the condition characterized by sustained elevated blood pressure. However, it is unclear how and why such apparently distinct processes coincide in hypertension. Elevated levels of certain vasoactive G-protein-coupled receptor agonists (such as catecholamines, endothelin-1, and angiotensin II) can explain, at least in part, the development and progression of many hypertensive disorders. Here, we review findings made by other investigators and ourselves suggesting that enhanced vascular tone, oxidative stress, and hypertrophic growth characteristically induced by these agonists involve the transactivation of growth factor receptors. The first step in this transactivation mechanism is agonist-induced activation of metalloproteinase-dependent shedding of growth factors. Shed growth factors then trigger intracellular signaling cascades necessary for growth, production of reactive oxygen species, and maintenance of vascular tone. If this hypothesis is proven generally correct, then transactivation blockers have general therapeutic potential in hypertension regardless of the causative agonist.
Transition structures and timing of transfer from paediatric to adult-based care after kidney transplantation in Germany: a qualitative study

Field: Health Professions (Health Sciences)

Objectives It is known that transition, as a shift of care, marks a vulnerable phase in the adolescents’ lives with an increased risk for non-adherence and allograft failure. Still, the transition process of adolescents and young adults living with a kidney transplant in Germany is not well defined. The present research aims to assess transition-relevant structures for this group of young people. Special attention is paid to the timing of the process. Setting In an observational study, we visited 21 departments of paediatric nephrology in Germany. Participants were doctors (n=19), nurses (n=14) and psychosocial staff (n=16) who were responsible for transition in the relevant centres. Structural elements were surveyed using a short questionnaire. The experiential viewpoint was collected by interviews which were transcribedverbatim before thematic analysis was performed. Results This study highlights that professionals working within paediatric nephrology in Germany are well aware of the importance of successful transition. Key elements of transitional care are well understood and mutually agreed on. Nonetheless, implementation within daily routine seems challenging, and the absence of written, structured procedures may hamper successful transition. Conclusions While professionals aim for an individual timing of transfer based on medical, social, emotional and structural aspects, rigid regulations on transfer age as given by the relevant health authorities add on to the challenge. Trial registration number ISRCTN Registry no 22988897; results (phase I) and pre-results (phase II).
The coming of the Greeks. I

Field: Arts and Humanities (Social Sciences)

Judging from repetitious appearances of her marital arms in the painted line-endings, the Psalter-Hours John Rylands Library Latin MS 117 probably belonged to Jeanne of Flanders (c.1272–1333), daughter of Count Robert III of Flanders and in 1288 second wife to Enguerrand IV of Coucy. Yet the line-endings also contain some 1,800 diminutive painted escutcheons, many of which refer to other members of the local nobility active during the 1280s. This study, based on an exhaustive survey of the total heraldic and codicological evidence, suggests that the majority of the extant Psalter predated the Hours and that the two parts were combined after the 1288 marriage. The ‘completed’ manuscript bears witness to major events that unfolded in and around the Coucy barony over the course of the decade. It suggests a complex relationship between Jeanne of Flanders and a lesser member of the local nobility, a certain Marien of Moÿ, who may have served as her attendant.
Transpersonal approaches

Field: Arts and Humanities (Social Sciences)

Transpersonal approaches within therapy have grown from a variety of roots and alliances. The green movement in politics joins loosely and intermittently with the human potential movement in psychotherapy, feminism and mystical traditions in religion. The result brings together arts, humanities and social sciences. Capra, Zukav and Bohm argue that this transpersonal vision is consistent with modern physics. It speaks of the 'quiet revolution', in values and actions, away from materialism, egocentricity and impersonal organizations, and towards spiritual regeneration and more humanized living. At one extreme, this 'new age' may hover among broken down caravans and bedraggled travellers. At another, it has been celebrated by smash-hit, million-seller writer-prophets on an international lecture circuit. It speaks of cooperation rather than confrontation, and the abandonment of attachment to conventional personal and social identity.
[Analysis of lesions from mandibular fractures in children. Therapeutic methods (author's transl)].

Field: Dentistry (Health Sciences)

A statistical analysis was conducted in 22 recent cases of fracture and 4 cases of post-fracture ankylosis treated in the "Hôpital Bretonneau" over the last 5 years. The results demonstrated the frequency of often unrecognized associated condylar lesions (19 of 22 cases of recent fracture). They also emphasized the need to avoid conventional bimaxillary blocking, which when required should be conducted with the "open mouth", in cases of high or severe lesions of the mandibular condyles. Reconstruction of the condylar head involves re-insertion of the meniscular cap associated with regain of function, rather than conservation at any price of the condylar head, even recovered with its "fertile" cartilage.
The equation-of-motion coupled cluster method for triple electron attached states

Field: Chemistry (Physical Sciences)

The initial implementation of the triple electron attachment (TEA) equation-of-motion (EOM) coupled cluster (CC) method is presented, aiming at the description of electronic states with three open shell electrons outside a suitably chosen closed shell vacuum. In particular, such an approach can be used for describing dissociation of chemical bonds predominantly formed by three valence electrons, for example, in LiC and NaC molecules. Both ground and excited states are considered while rigorously maintaining the correct spin value. The preliminary results show a correct asymptotic behavior of the dissociation curves. At the same time, we emphasize that a chemically accurate description will require an extension of the minimal TEA-EOM-CC model introduced here, analogous to those already used in the double ionization potential and double electron attachment methods.
12355 An Adolescent Female With Congenital Lipodystrophy Presenting With Repeated Acute Metabolic Decompensations Rescued By A Novel Leptin Receptor Agonist

Field: Medicine (Health Sciences)

Abstract Disclosure: D.M. Chambers: None. Y. Chan: None. M.K. Crocker: None. Patient SH is a now 17-year-old female treated for generalized congenital lipodystrophy with a course complicated by severe hypertriglyceridemia, type 2 diabetes mellitus, hypertension, hepatosteatosis, and intermittent menstrual irregularity. She had been managed successfully with metreleptin for 2 years, but in 2022-2023, she developed repeated episodes of pancreatitis (4 times over a 14-month period) secondary to severe hypertriglyceridemia (serum triglycerides &gt;8000 mg/dL). During her admissions, she had markedly increased insulin requirements (up to 12 units/kg/day) with refractory hyperglycemia despite maximal treatment with metreleptin, empagliflozin, and oral semaglutide. In the clinical context of her acute metabolic worsening, she was suspected of having a neutralizing antibody against metreleptin. Serum leptin was undetectable 1 hour after observed metreleptin doses; direct measurement of neutralizing antibodies is pending. She was transitioned from metreleptin to mibavademab, an investigational leptin receptor agonist, on an expanded use IND. She subsequently experienced significant improvements in her fasting triglyceride levels (&lt;300 mg/dL) with no subsequent episodes of pancreatitis since starting therapy in August 2023. She has also had improvements in other aspects of her metabolic health including decreased insulin requirements with decreasing hemoglobin A1c, decreased need for adjunctive lipid and hypertension therapy, and improving menstrual regularity. Her clinical course demonstrates: 1) clinical indicators of a rare but serious loss of efficacy of metreleptin therapy; 2) adjunctive options for management of generalized lipodystrophy; and, 3) an individual experience with a novel leptin agonist therapy in the treatment of generalized lipodystrophy. Presentation: 6/3/2024
Signaling in Late Preconditioning

Field: Medicine (Health Sciences)

Information about reprints can be found online at: Reprints: document. Permissions and Rights Question and Answer about this process is available in the located, click Request Permissions in the middle column of the Web page under Services. Further information Editorial Office. Once the online version of the published article for which permission is being requested is can be obtained via RightsLink, a service of the Copyright Clearance Center, not theCirculation Researchin Requests for permissions to reproduce figures, tables, or portions of articles originally publishedPermissions: by guest on April 28,
Research Article Anaemia among Female Undergraduates Residing in the Hostels of University of Sri Jayewardenepura, Sri Lanka

Field: Health Professions (Health Sciences)

Copyright © 2014 Gayashan Chathuranga et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Anaemia is a major public health problem that has affected around 25 % of the world’s population. An analytical cross-sectional study was performed on 313 female undergraduates residing in hostels of University of Sri Jayewardenepura, Sri Lanka, during year 2011. Objective of this study was to determine prevalence and contributing factors to anaemia among the study population. Haemoglobin concentration was assayed using cyanomethaemoglobin method. A pretested self-administered questionnaire was used to retrieve information regarding dietary habits and personal factors of participants. Descriptive statistical methods, chi-square test, and independent sample t-test were used to analyze data. Of the 302 females, 17.5 % (
Effect of Furan Resin Sand on Carburization Defects of Ultra-Low Carbon Steel Casting

Field: Materials Science (Physical Sciences)

Using furan resin sand to produce test pieces of ultra-low carbon steel, carburization rule and mechanism of ultra-low carbon steel test pieces surface were researched by using spectral analysis, electron probe scanning, microscopic metallographic analysis and mechanical test and so on. The research showed that test pieces surface carburization was very serious, the carbon content on test pieces surface was 2 to 7 times than that of test pieces body, and depth of carburizing layer reach to 8-12 mm. The reason of the above mentioned results is that the resin decomposed into carbon atom and CO2, CO, CH4, etc. gases which dissociated into carbon atom in the interface of the liquid steel. These carbon atoms dissolve directly into liquid steel and inward diffuse with liquid steel solidifying. This process caused test pieces surface carburization. The research also showed surface hardness of test pieces was increased with the carbon content increasing, and needle type martensite was found in the surface layer microstructure. With the thickness of test pieces increasing, the content and depth of carburization were increased.
Cortical mechanisms of hypnotic pain control

Field: Neuroscience (Life Sciences)

Abstract Hypnosis has been known for centuries to modify significantly subjects ‘ perceptions and other psychological processes. Thus, several studies have shown that colourful visual stimuli can lose their brightness and colour, and physically strong auditory stimuli can become almost inaudible when subjects are exposed to corresponding hypnotic suggestions of colour blindness or deafness (Revenstorf 1993). Furthermore, the skin of fakirs can become deeply penetrated by knives, daggers or swords without pain and without negative emotions while being in a hypnotic-like trance, whereas the same physical event would be perceived as terribly painful by the same persons outside the trance state (Larbig 1988; Larbig and Miltner 1990).
Formal Semantics for Iconic Gesture

Field: Computer Science (Physical Sciences)

We present a formal analysis of iconic coverbal gesture. Our model describes the incomplete meaning of gesture that’s derivable from its form, and the prag-matic reasoning that yields a more spe-cific interpretation. Our formalism builds on established models of discourse in-terpretation to capture key insights from the descriptive literature on gesture: syn-chronous speech and gesture express a sin-gle thought, but while the form of iconic gesture is an important clue to its inter-pretation, the content of gesture can be re-solved only by linking it to its context. 1
Designing a complementary system of authentication base on galvanic body communication

Field: Computer Science (Physical Sciences)

This article deals with the design, development and operation of security applications oriented in bodycommunication, along with analysis, evaluation and design of a complementary system of user authentication through fingerprint galvanic coupling and an authentication code. Different tests of galvanic model were performed to observe the frequency range, bandwidth, and also the conductivity of the human body. This way you can get a model safer and easier for users authentication. Besides it was designed and implemented a method to limit the transmission power and the signal is only transmitted in one part of the body, and prevent the information can be spread to other areas of the body. This galvanic method excludes the emission of electromagnetic fields which reduces the possibility of information theft. © 2016 IEEE.
[Prognosis of outcomes and choice of surgical strategies in general purulent peritonitis].

Field: Medicine (Health Sciences)

A comparative analysis of the results of surgical treatment of 233 patients with general peritonitis of different etiology was carried out. It is demonstrated that Manheim's index of peritonitis (MIP) may be used not only for prognosis of outcome, but also as one of main criteria for programmed revisions and sanations of the abdominal cavity, and appliance of laparostomy. Combination of MIP with clinical and laboratory evaluation of endotoxicosis severity permits one to define objectively indications for early preventive methods of enteral and extraorganic detoxication. Differential approach to choice of treatment policy reduced postoperative lethality in general peritonitis from 24.4 to 15.8%.