jimnoneill/paper-to-field-training huggingface dataset:
Hematological Findings Associated with the Use of Licorice and Silymarin in Cisplatin-Treated Rats

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The purpose of this study was to assess the effect of licorice and silymarin supplementations on some hematological parameters in cisplatin treated albino rats.A total of 72 normal male albino rats' weight 150 -200 gm.The rats were allowed for acclimation for one week at the animal shelter.The rats were divided randomly into six groups, each with 12 rats.Group (1): normal control group and fed with commercial balanced diet.Group (2): licorice extract orally treated group for 6 weeks at a rate of 2 gm/kg body weight.Group (3): silymarin orally treated group at a rate of 100mg/kg every day for six weeks.Group (4): served as hepatotoxic group treated by injection of cisplatin (CP) intraperitoneally in a dose of 1.5 mg/kg body weight every two weeks for three weeks starting from the 4 th week of the experiment.Group (5): received licorice extract orally treated group at a rate of 2 gm/kg body weight for 6 weeks.and injected cisplatin intraperitoneally in a dose of 1.5 g/kg body weight repeated twice a week for 6 weeks starting from the 4 th week of the experiment.Group (6): received silymarin orally treated group at a rate of 100mg/kg daily for 6 weeks.and injected cisplatin intraperitoneally in a dose of 1.5 mg/kg body weight every two weeks for six weeks starting from the 4 th week of the experiment.The purpose of this study was to investigate the effects of oral administration of licorice and silymarin extracts for 6 weeks on some hematological parameters in cisplatin treated albino rats.These effects were explored by measuring hematological parameters.Group injected with cisplatin revealed decrease RBCs count, Hb concentration, and values of PCV, MCV, MCH and MCHC.When compared with normal control group, there is microcytic hypochromic anemia associated with leukocytosis, neutrophilia, eosinophilia, and lymphopenia, also thrombocytopenia is recorded.All these parameters were improved in treated (licorice and silymarin) CP intoxicated groups compared with non-treated CP intoxicated group. Randa, m. Abdel hamed et al.The findings of this study showed that, administration of licorice and silymarin are effective when taken orally for 6 weeks, they alleviate the changes recorded in the hematological parameters induced by cisplatin injection.
Overtourism and Resident Resistance in Budapest

Field: Social Sciences (Social Sciences)

The phenomenon of "overtourism" in cities is hardly a new one, however the process and nature of resistance has changed significantly in recent years. The work of Colomb and Novy [2017. Protest and Resistance in the Tourist City. London: Routledge] encapsulates the manifestations of resistance in numerous cities. They argue that many of the contestations surround tourism rather than being about tourism. This paper explores resident resistance in the Hungarian capital city Budapest. This includes the rejection of the Olympic bid in 2017 and protests surrounding a controversial new development project in the city park. An uncontrolled night-time economy has also adversely affected local resident quality of life. Questionnaire data collected from both local residents and tourists as well as an analysis of Facebook sites using Sentione software will be used to illustrate the key areas of discontent. The research attempts to demonstrate that tourism is often marginal rather than central to residents' discontent and resistance to developments.
SKELETAL HEALTH ASSESSMENT IN BRAZILIAN MEN WITH CELIAC DISEASE AT DIAGNOSIS: HOW IMPORTANT IS IT?

Field: Medicine (Health Sciences)

ABSTRACT Background: Low bone mass density (BMD) is an extraintestinal finding in celiac disease (CD). This may result in bone fractures leading to loss in quality of life. Objective: To assess BMD in male CD patients at diagnosis according to the patient’s age. Methods: Descriptive retrospective carried out during the period between 2013 and 2023 in a single office that studied dual-energy X-ray absorptiometry (DXA) results in 28 male patients with a recent diagnosis of CD, divided into three groups: group 1 (age up to 18 years); group 2 (from 19 to 49 years of age) and group 3 (over 50 years of age). Were studied demographic and anthropometric parameters, time delay between symptoms onset and CD diagnosis and fracture occurrence. Results: Celiac patients studied had median age 36.0 years (IQR=16.5-50.7). Among them, 39.3% had osteopenia and 14.3% had osteoporosis. Only 36% of the sample had normal DXA values (group 1 with 37.5%; group 2 with 46% and group 3 with 14.2%). No pathological fracture was observed in this sample. CD diagnosis delay observed had median 1.0 year (IQR=1.0-4.7). When the number of individuals with normal and abnormal DXA results were compared, there was no difference in body mass index, time of diagnosis delay or Marsh classification (P=0.18). Conclusion: Male patients at the time of CD diagnosis showed a high prevalence of low BMD, which was particularly evident in individuals over 50 years of age.
Assessment of the anesthetic effect of modified pentothal sodium solution on Sprague-Dawley rats

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Clinically, pentothal sodium has been widely used for primary and general anesthesia induction. Also, it has been used to effectively inhibit convulsion. Pentothal sodium has a strong inhibitory effect on the respiratory center, excessive drug administration, and rapid dose rate that cause death of experimental animals on the respiratory depression. This study used a modified pentothal sodium solution to investigate its anesthetic effect. The pentothal sodium solution was modified based on pentothal sodium upon additions of magnesium sulfate, propylene glycol, and pure ethanol. The anesthetic effect of the modified pentothal sodium on Sprague–Dawley (SD) rats was investigated by comparing traditional pentothal sodium and ketamine; 60 SD rats were randomly divided into three groups. Each group was treated with traditional pentothal sodium, modified pentothal sodium, or ketamine, respectively, via intraperitoneal injection. The symptoms of experimental rats were observed, and onset time and anesthetic time were both recorded. The data were analyzed using statistical software. There were no significant differences in onset time and anesthetic time between the three groups. The variation of onset time and anesthetic time of the group treated with modified pentothal sodium was shorter than that of the other two groups. Furthermore, the number of anesthetic rats after the first injection was significantly higher than that of the other two groups. The modified pentothal sodium is capable of providing a stable anesthetic effect. The function and effect are much better than traditional pentothal sodium and ketamine.
Xinshenghua granule in treatment of 80 cases of vaginal hemorrhage after drug abortion

Field: Medicine (Health Sciences)

Objective To observe the effect of Xinshenghua granule on vaginal hemorrhage after drug abortion.Methods One hundred and fifty patients with vaginal hemorrhage after drug abortion were devided into two groups randomly:the treatment group(80 cases) taking Xinshenghua granule 12.0 mg,2 times per day for 5 days,and the control group(70 cases) taking adrenosem for 5 days.Antibiotics were used after drug abortion.Results There was no significant difference in the amount of vaginal bleeding between the two groups(P0.05).The duration of vaginal hemorrhage in treatment group was lower than that in control group(P0.05).Conclusion Xinshenghua granule can reduce the duration of vaginal hemorrhage after drug abortion.
Home Bias in Portfolios and Taxation of Asset Income

Field: Economics, Econometrics and Finance (Social Sciences)

Intuitively, the observed bias in individual portfolios plausibly explains the international capital immobility reported by Feldstein and Horioka (1980) as well as the survival of taxes on capital income. These intuitions are examined in a model where consumers prefer to consume domestically produced goods. The results show that international capital immobility is indeed present in the model: extra domestic savings generate extra investment primarily in the home country. When monetary policy focuses on exchange rate stabilization random domestic prices cause individuals to heavily invest in domestic equity as a hedge against price fluctuations. However our findings show that the specialization of equity portfolios does not necessarily facilitate the taxation of capital income. While random equity returns do facilitate taxes on equity income, as shown in Gordon and Varian (1989) and Huizinga and Nielsen (1997), random consumer prices appear to undermine taxes on capital income.
Efficient Estimation of More Detailed Internet IP Maps

Field: Computer Science (Physical Sciences)

Router-level maps of the Internet implicate a large body of research on network management, overlay networks, performance evaluation, and security. The inaccuracies in these maps result in misleading conclusions. In this paper, we propose AROMA (accurate router-level map), a tool to infer router-level, layer-3 maps of the Internet. AROMA uncovers more routers and links in targeted (mapped) networks than existing tools with less probing overhead. For example, AROMA reveals the same number of routers and links as the Rocketfuel tool after sending less than 5.1% of the number of probes used by Rocketfuel, and reveals at least 100% more links and routers than Rocketuel while using the same number of probe packets. We use AROMA to draw the maps of four major ISP networks and revisit the conclusions drawn by earlier research on the Internet IP structure. Surprisingly, AROMA maps consistently reveal that core routers have a higher degree than edge routers in contrast to the recently suggested higher connectivity of routers at the network edge. The maps also reveal that routers' degree distribution follows a power-law in contrast to the recently suggested Weibull distribution.
Fibroscan in Detection of Non-alcoholic Fatty Liver Disease in Patients on Peritoneal Dialysis - a Pilot Study

Field: Medicine (Health Sciences)

Continuous ambulatory peritoneal dialysis (CAPD) is associated with a number of metabolic abnormalities. Among others, lipid and carbohydrate abnormalities as well as constant albumin and amino acid losses can lead to non-alcoholic fatty liver disease (NAFLD). AIMS & The aim of this study was to investigate whether patients with end-stage renal disease (ESRD) on CAPD had increased tendency to NAFLD and to analyze whether dialysate composition, lipid profile, duration of CAPD and comorbidities play a role in NAFLD occurrence. We studied 22 patients of CAPD (F10:M12) with a mean age of 58.8 ± 12.9 (26-78) years. No patient was hepatitis B and anti-hepatitis C virus positive and none had history of alcohol abuse. In all patients, BMI, mean glucose concentration in dialysate, serum fasting glucose, AST, ALT, cholesterol, triglyceride, albumin and CRP were measured. Fibroscan (Echosenc) was performed in all patients in order to detect and quantify liver steatosis and fibrosis. The cut-off value for defining liver steatosis was Controlled Attenuation Parameter ≥238 dB/m and for liver fibrosis the stiffness of >7 kPa. Dyslipidemia was found in 14 patients (63.63%) and seven patients (31.81%) had diabetes mellitus. Mean concentration of dialysate glucose was 1.41% ± 0.14 (1, 36-1, 81). The NAFLD was observed in 14 patients (63, 63%), and among them eight patients (57, 14%) had also liver fibrosis. All of diabetic patients had NAFLD whereas just 50% of ESRD patients with dyslipidemia had NAFLD. Interestingly, not statistically significant differences in all measured parameters between NAFLD positive and negative group of patients were observed. The severity of liver steatosis was positively correlated with serum fasting glucose (r=0, 516 ; p=0, 014) and BMI (r=0, 441 ; p=0, 40) and negatively correlated with haemoglobin (r=-0, 576 ; p=0, 005) and serum calcium level (r=-0, 448 ; p=0, 037). Our results showed that ESRD patients on CAPD have high prevalence of NAFLD. As far as we know this is the first study of Fibroscan using approach for NAFLD detection in ESRD patients on CAPD.
Alternative Product Structures and Product Variant Codification: Experiences from reforming the assembly line – possibilities for physical and administrative modularisation

Field: Business, Management and Accounting (Social Sciences)

This publication explains the differences between administrative and physical modularisation, which in turn implies new opportunities to deal with so-called just-in-time (JIT) deliveries. Thus are e.g. the nowadays coagulated road traffic system, in fact, possible resolve (as were the product planning system that hampered the performance of the Volvo Uddevalla plant, it was relying on traditional codification of the product variants, thus were the reduced so-called production losses never possible to accumulate between automobiles for each and every small parallel workgroup) (the information system was totally new – nothing external was allowed to enter the shop floor of this plant – but still were some assembly line approaches was still at hand).A comment: The most socio-technically advanced assembly system designs inventible requires reformed/reconfigured information systems dealing with product data (which in turn defines the product architecture and product variation). In fact, no any such (real-life) plant or assembly system would work as anticipated otherwise. And this publication is to some extent describing some selected aspects of this (very) dilemma (changing information systems are usually not something considered than designing assembly systems) (thus are totally new plants – and in turn totally new information systems – most often the real practical change to create something unorthodox) (however, which scientist will gain such opportunities, this is really rare, i.e. the projection of the Volvo Uddevalla plant was thus an exception and the trust given by the industry – by Volvo Uddevalla project organisation – was appreciated by some of the authors).
Homeomorphism Groups of Certain Topological Spaces

Field: Mathematics (Physical Sciences)

Let G(F) denote the group of all homeomorphisms of the topological space F onto itself topologized under the point-open topology. We will call two such groups, G(F') and G(F), isomorphic if there exists a one to one correspondence between them which is a homeomorphism as well as an algebraic isomorphism. In general the isomorphism of two groups G(F') and G(F) does not imply the homeomorphism of the spaces F' and F. However, we shall prove here that this implication does hold under certain limitations on the class of topological spaces to be allowed. Most important among these limitations is a condition of homogeneity. This condition is made precise as follows: We call an n-tuple of objects a proper n-tuple if it contains no repetitions. A space F is called n-homogeneous if for every pair (Xl , X2, - * , .Xn), (yi, Y2, - - *, Yn) of proper n-tuples of points of F there exists a homeomorphism g belonging to G(F) such that g(xi) = yi for each i. F is called w-homogeneous if it is n-homogeneous for each n. Now we may
Fruit and Vegetable Prescription Program for Diabetes Control Among Community Health Centers in Rural Idaho and Oregon

Field: Health Professions (Health Sciences)

A Fruit and Vegetable Prescription program (12–16 weeks, 2018–2020) was implemented at community health centers serving rural communities in the northwestern United States. The impact of the program on type 2 diabetes control was evaluated. Reductions in mean hemoglobin A1C were statistically significant (P < .01). The percentage of participants with critically high blood glucose levels (A1C > 9%) decreased from 76% (114/151) to 41% (62/151; P < .01). The findings mirror those of similar programs. The sustainability of these beneficial interventions, however, relies on improved access to preventive care. (Am J Public Health. 2022;112(7):975–979. https://doi.org/10.2105/AJPH.2022.306853 )
P3‐164: Macro and micro‐structural MRI changes associated with diabetes in non‐demented older adults

Field: Neuroscience (Life Sciences)

Previous brain MRI studies have shown diabetes associated with cerebral atrophy, however few studies have investigated micro-structural measures, which may reveal anatomical associations not detected on conventional MRI. To better elucidate mechanisms that underlie the association between diabetes and cognitive impairment, we evaluated macro- and micro-structural brain MRI measures for the total brain and regions associated with memory, processing speed and executive function in a group of non-demented elders with and without diabetes. MRI measures were obtained on 308 non-demented elders (mean age 83.3 years) from the Healthy Brain Substudy of the Health ABC study. Of the participants, 85 had diabetes (defined by self-report, use of hypoglycemic medication or elevated fasting glucose). We performed a series of linear regressions and used standardized betas to estimate the cross-sectional association between diabetes and macro-structural (gray matter volume (GMV); white matter hyperintensities (WMH)) and micro-structural (mean diffusivity (MD), a measure of structural damage; fractional anisotropy (FA), an index of tract integrity) measures for the total brain and for tracts and regions of interest (ROIs). Models were adjusted for age, race and sex; ROIs were additionally adjusted for total brain volume. In multivariate adjusted models, diabetes was associated with lower total GMV (P=0.0006) and total brain volume (GM, WM, and cerebral spinal fluid; P=0.04), and greater cerebral atrophy (P=0.02). There was no association with WMH volume or GMV in the ROIs except for the putamen (P=0.02 for left and right). On microstructural measures, diabetes was associated with reduced FA for white matter in the total brain (P=0.006) and greater MD for the hippocampus (P=0.006 left; P=0.01 right), dorsolateral prefrontal cortex (P=0.0007 left; P=0.002 right), left posterior cingulate (P=0.02) and the right putamen (P=0.02). Further adjustment for stroke, hypertension, and MI produced similar results. Diabetes is associated with smaller GM volume, total brain volume, greater atrophy. Micro-structural measures revealed reduced FA for total WM and greater MD in regions associated with memory and executive function, in particular in the hippocampus and dorsolateral prefrontal cortex. Further studies are needed to determine if these structural changes associated with diabetes predict risk of cognitive decline.
A Sampler of What's New in Base SAS ® 9.2

Field: Computer Science (Physical Sciences)

Coding with SAS is easier than ever with SAS 9.2. This paper highlights the top new features and performance improvements in DATA step, PROC SQL, and PROC SORT. Included are writing functions with DATA step syntax, improved performance when accessing an external database from PROC SQL, more intuitive and culturally acceptable sorting with PROC SORT, and several Top 10 SASware Ballot items.
Unraveling Complex MicroRNA Signaling Pathways with Activity‐Based Protein Profiling to Guide Therapeutic Discovery**

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract microRNAs (miRNAs) are important cell factors that can play essential roles, such as regulating transcription factors in embryonic development. Traditionally, microarrays or high‐throughput sequencing of crosslinked protein‐RNA complexes have been applied to deduce direct targets, but these techniques fail to account for biomolecular interactions with functional consequences. Activity‐based protein profiling (ABPP) represents a promising alternative to conventional methods and was applied to the discovery of functional targets of human miRNAs. ABPP identified downregulation of MGLL and LIPC, in response to miR‐185 and miR‐27b, respectively. Hepatitis C virus (HCV) infection was found to be modulated by these indirect downstream effectors. These findings highlight the importance of identifying functional targets in developing novel ways to mimic or inhibit miRNA pathways. This review will focus on miRNA regulation and how ABPP can be used to study these pathways.
[Atrial fibrillation and thyroid gland].

Field: Medicine (Health Sciences)

Many diseases can lead to atrial fibrillation and one of these is thyroid disfunction. The prevalence of atrial fibrillation does not differ between subclinical and overt hyperthyroidism. Hypothyroidism also can be associated to atrial fibrillation. Low-T3 syndrome is considered a risk factor in cardiac patients. In 100 patients affected by atrial fibrillation we studied the thyroid function and performed ultrasound examination of the thyroid gland. 30 patients had a low-T3 syndrome, 66 (38 > or =10 mm) patients had thyroid nodules, while just 10 patients had an abnormal thyroid function. So, in patients affected by atrial fibrillation, we suggest to study the levels of thyroid hormones and, even if these are normal, to perform an ultrasound examination of the gland.
Influence of forest disturbances on backscatter of the airborne L-band synthetic-aperture radar in a larch forest in northern Japan

Field: Earth and Planetary Sciences (Physical Sciences)

This paper is a case study on the detection of forest disturbances in airborne synthetic-aperture radar (SAR) data. We investigated changes in the L-band SAR backscattering coefficient (σ0) following thinning and a typhoon in a larch forest in northern Japan. The thinning caused changes of intermediate magnitude in the above-ground biomass (AGB), whereas the typhoon broke or uprooted most of the trees, thereby significantly changing the forest structure without changing the biomass. Thinning led to back-scattering coefficients change of less than about 1 dB; HV polarization was most sensitive to the change in AGB, and HH was insensitive to it. In the case of the typhoon, VV was sensitive to the change in forest structure, whereas HH and HV were insensitive to it, suggesting that the tree trunks, which were felled in one direction by the typhoon, enhanced the backscattering signal of the polarisation that accorded with the trunk direction.
Improvement of the gelling properties of meat emulsion gel by the addition of porcine sarcoplasmic proteins

Field: Agricultural and Biological Sciences (Life Sciences)

ABSTRACT The effects of porcine sarcoplasmic proteins (SP) on the physicochemical properties of meat emulsion gel were examined. Meat emulsion was prepared from water‐washed pork meat (WWM), corn oil and SP. Whole SP (W‐SP) enhanced the breaking stress of the WWM emulsion gel as well as other animal proteins in the presence of 0.2 mol/L NaCl. The breaking stress of the emulsion with W‐SP increased with an increase in corn oil content. Furthermore, this tendency was more noticeable at a lower NaCl concentration (0.15 mol/L) rather than at 0.45 mol/L NaCl. Ammonium sulfate (AS) treatment fractionated W‐SP into three portions (SP‐f1, SP‐f2 and SP‐f3), which were the precipitates at 0–50% and 50–75% AS saturation and the supernatant at 75% AS saturation, respectively. The fractions SP‐f2 and SP‐f3 increased the gel strength more than W‐SP. In particular, the fraction SP‐f3 increased the gel strength approximately 10‐fold compared to the control. Sodium dodecyl sulfate‐polyacrylamide gel electrophoresis analysis showed that SP‐f3 had several kinds of proteins and a main protein with a molecular mass of 35 kDa, which corresponded to glyceraldehyde 3‐phosphate dehydrogenase. These results indicate that the influence of SP should not be ignored when processing of low‐salt meat products and the fraction SP‐f3 has a gel‐enhancing factor for myofibrillar proteins.