jimnoneill/paper-to-field-training huggingface dataset:
Probiotics as an adjunct in the treatment of canine atopic dermatitis: a systematic review and meta-analysis of <i>in vivo</i> studies in dogs

Field: Veterinary (Health Sciences)

Probiotics have been suggested as a treatment for canine atopic dermatitis, a form of dermatopathy common in dogs. This systematic review and meta-analysis aimed to evaluate the effect of probiotics as an adjuvant in treating canine atopic dermatitis in vivo studies with dogs. The study was conducted following the PRISMA guidelines. Only clinical studies in dogs with atopic dermatitis that received intervention with probiotics were selected, being just original articles in English from the last 5 years (2019-2023). A total of 293 articles were obtained, and after the inclusion criteria, only 5 articles were eligible and included in the systematic review and meta-analysis. The 5 studies used different probiotics at concentrations of 108 to 1010CFU/mL/g, 3 studies with oral administration for 12 weeks, and 2 studies with topical use for 4 weeks. The meta-analysis results show that probiotics did not present significant effects against atopic dermatitis by evaluating the CADESI-4 scale (P=0.08) and the PVAS scale (P=0.85). Furthermore, regarding the method of administration of probiotics (oral or topical), the meta-analysis showed that there were also no significant results when the disease index was evaluated using CADESI-4 (P=0.07) or PVAS (P=0.92). We concluded that, even without significant effects, all trials showed a reduction in CADESI-4 and PVAS scores, reflecting a reduction in the severity of atopic dermatitis in dogs that used probiotics as treatment adjuvants.
Potret Islam Tradisional â€œDayah dan Ulama di Aceh Abad Ke-20â€ dalam Perspektif Sejarah

Field: Arts and Humanities (Social Sciences)

At the time of the Sultanate, dayah offers three levels of teaching (junior), rangkang, balee (senior) and dayah manyang (University). In some there were only junior dayah (rangkang) and senior (balee), whereas elsewhere found only university level course. Even so, in a certain place there are also three levels at once, ranging from junior to University. Before a pupil studying in Dayah, they've been able to read the Quran. The ability to read the Quran, they earn from home or from a teungku in meunasah. Information about very rare curriculum that can be obtained from historical background dayah; not a scholar was explaining about this \n \nPada masa kesultanan, dayah menawarkan tiga tingkatan pengajaran, rangkang (junior), balee (senior) dan dayah manyang (universitas). Di beberapa dayah hanya terdapat junior (rangkang) dan senior (balee), sedangkan di tempat lain hanya ditemui tingkat universitas saja. Meskipun demikian, di tempat tertentu juga terdapat tiga tingkatan sekaligus, mulai dari junior sampai universitas. Sebelum murid belajar di Dayah, mereka sudah mampu membaca al-Quran. Kemampuan membaca Al-Quran tersebut, mereka dapatkan dari rumah atau dari seorang teungku di meunasah. Informasi tentang kurikulum sangat langka yang bisa didapatkan dari latar belakang sejarah dayah; tidak seorang sarjana pun yang menjelaskan tentang hal ini \n \nKata Kunci: Dayah, Pendidikan Islam, Aceh.
Distribution of deletions and seven point mutations on CYP21B genes in three clinical forms of steroid 21-hydroxylase deficiency.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

To characterize mutations in the CYP21B gene that are responsible for congenital adrenal hyperplasia (CAH), DNA samples from 91 French patients have been studied by allelic-specific oligonucleotide hybridization and Southern blot analysis. Seven sites mostly found in the CYP21A pseudogene and deletions of the functional CYP21B gene have been screened. Gene conversions involving small DNA segments accounted for 57% of the tested mutations and probably cause 74% of the mutations responsible for the disease. Complete deletion of the CYP21B gene accounted for 18% of the CAH mutations in the whole sample and for 21% in the classical form of the disease. Three mutations were found associated with specific clinical forms of the disease: a G-C substitution in the seventh exon was associated with the late-onset form of the disease, and both an 8-bp depletion in the third exon and complete deletion of CYP21B were associated with the salt-wasting form.
Sensor Fault Detection, Isolation and Accommodation Based on the Stable Kernel Representation

Field: Computer Science (Physical Sciences)

This paper proposes a novel sensor fault detection, isolation and accommodation (FDIA) scheme based on the stable kernel representation. The core of the study is to design the virtual sensor for each sensor channel. The virtual sensors are designed based on the data-driven stable kernel representation to capture the system dynamics. In addition, the existence condition of the virtual sensors is also discussed in details. The sensor fault is detected and isolated based on the probability analysis of residuals. The fault accommodation is implemented by switching on the virtual sensor. The proposed method is finally validated on a simulated 2-input-3-output system under the closed-loop conditions.
Self-Reported Sleep Latency in Postmenopausal Women

Field: Medicine (Health Sciences)

The aim of this study was to access how self-reported sleep latency (SRSL) was affected by sleep habits, mood, and circadian rhythm in postmenopausal women. Subjects (n=384, 67.9+/-7.7 yr) completed sleep and mood questionnaires, sleep log and actigraphic data. The major urinary melatonin metabolite (6-sulphatoxymelatonin, aMT6s) was assayed in fractional urine specimens for two 24-hr intervals. Although SRSL (26.5+/-24.4 min) and actigraphic sleep latency (ASL; 27.8+/-20.0 min) were correlated (r(s)=0.361, p<0.001), the short SRSLs tended to be underestimated whereas the long SRSLs tended to be overestimated as compared to ASL. SRSL was positively correlated with the scales of insomnia, mood and hot flash, hypertension, use of anti-hypertensive drugs and the acrophase and the offset of aMT6s. SRSL was negatively correlated with the global assessment of functioning scale in DSM-IV (GAF scale), and light exposure and wrist activity. Multiple linear regression analysis showed that the best-fit model to predict SRSL was light exposure, GAF scale, and use of anti-hypertensive drugs. SRSL may be determined by psychophysiological factors as well as circadian rhythm function. Therapeutic approaches suggested for trouble falling asleep might include increased daylight exposure, improvements in general health, and modification of anti-hypertensive pharmacotherapy.
A model of graded ischemia in the isolated perfused rat heart

Field: Medicine (Health Sciences)

Insertion of a flow pump into the Langendorff retrograde perfusion apparatus has permitted the production of stable, graded ischemia in hearts whose hemodynamic and metabolic response may be evaluated. Ventricular pressures were monitored with a modified balloon and catheter-tip manometer system, and oxygen consumption , lactate and glucose metabolism, and tissue high-energy phosphate stores measured. A 15-min stabilization period in 56 paced hearts was followed by 15 min of either full, 40, 30, 20, or 10% coronary flow, after which the ventricular tissue was freeze-clamped for tissue assay. Tissue creatine phosphate fell progressively from 23.7 in full flow hearts to 9.9 mumol/g dry wt after 90% reduction in flow. This was accompanied by a graded reduction in ATP from 20.3 to 14.0 mumol/g dry wt and a rise in AMP from 1.1 to 2.6 mumol/g dry wt. Tissue lactate rose progressively from 22.3 to 60.1 mumol/g dry wt. Hemodynamic function correlated with coronary flow. This preparation offers an opportunity to study pharmacological and metabolic interventions in ischemic heart disease.
Measuring Fitness and Precision of Automatically Discovered Process Models: A Principled and Scalable Approach

Field: Computer Science (Physical Sciences)

Automated process discovery techniques allow us to generate a process model from an event log consisting of a collection of business process execution traces. The quality of process models generated by these techniques can be assessed with respect to several criteria, including fitness , which captures the degree to which the generated process model is able to recognize the traces in the event log, and precision , which captures the extent to which the behavior allowed by the process model is observed in the event log. A range of fitness and precision measures have been proposed in the literature. However, existing measures in this field do not fulfil basic monotonicity properties and/or they suffer from scalability issues when applied to models discovered from real-life event logs. This article presents a family of fitness and precision measures based on the idea of comparing the $k$ th order Markovian abstraction of a process model against that of an event log. The article shows that this family of measures fulfils the aforementioned properties for suitably chosen values of $k$ . An empirical evaluation shows that representative exemplars of this family of measures yield intuitive results on a synthetic dataset of model-log pairs, while outperforming existing measures of fitness and precision in terms of execution times on real-life event logs.
[Treatment of migraine with vasopressin].

Field: Medicine (Health Sciences)

Clinicophysiological studies were performed in 186 patients with different variants of migraine. Of these, 153 received a course of treatment with the neuropeptide 8-arginine vasopressin. The pain paroxysms were reduced in intensity and duration in 87% of the cases in which also the cerebral hemodynamics, psychoemotional state, autonomic vascular conditions and working capacities improved. Prophylactic courses yielded positive results in 63 patients. The therapeutic effectiveness of 8-arginine vasopressin, and the simplicity of its administration without untoward effects and complications allowed us to recommend the drug to use in migraines, especially during the attacks.
A Paradigm for Promoting Visual Synthesis through Freehand Sketching

Field: Arts and Humanities (Social Sciences)

Research (Fish, 2004) suggests that everybody should be taught how to freehand sketch and utilise it as a tool for supporting the visualising instinct. A fundamental shift in philosophy of the technology education system in Ireland towards design driven subjects brought with it a need to develop practising teacher’s technological capabilities. This paper is concerned with the exploration and development of freehand sketching as a support tool for visual synthesis and creative discovery during design driven activities. The fundamental hypothesis tested was whether a set of empirically derived activities ranging from observation to imagination, improved the ability of students with novice sketching ability to develop, manipulate and synthesise graphical libraries through the medium of freehand sketching. 124 students of an Initial Technology Teacher Education programme participated in a journey through the activities as part of a third year undergraduate Design and Communication Graphics module. The study was carried out over a four week period, it involved eight hours of classroom based instruction and the sketching ability of all students was measured pre and post-instruction. Results from the study reveal a statistically significant increase in student’s ability to freehand sketch with notable improvement in their fluency and ability to synthesise concepts and geometries. Overall, the novel and original activities have a notable effect on student’s ability to form, manipulate and synthesise visual information and communicate this through freehand sketching. The model presented has potential to be successively implemented by other teachers in a variety of educational settings and student populations.
Study on the Synthesis and Performance of AA/AMPS Binary Copolymer

Field: Chemical Engineering (Physical Sciences)

The copolymer is prepared from the monomers of acrylic acid(AA) and 2-acrylamido-2-methyl-propanesulfonic acid(AMPS) in water.The effects of polymers concentration,Ca~(2+) concentration,pH,dispersant for ferric oxide and corrosion protection on the corresponding product's scale inhibiting performance have been studied.The results show that the copolymer possesses quite good effect on reducing scale depositions of CaCO_3,Ca_3(PO_4)_2,capabilities of dispersing for ferric oxide and corrosion protection.
Wild Fodder Yielding Plants in the Protected Areas of Bangladesh

Field: Agricultural and Biological Sciences (Life Sciences)

Wildlife habitat is degrading worldwide due to myriads of biotic and abiotic reasons. The governments across the world countries are trying to halt the degradation through declaring protected areas (PAs) with potential wildlife habitats and strengthening conservation initiatives. These measures are expected to uphold the richness and diversity of the fodder yielding plants. But there is a dire necessity of information on composition and overall status of the fodder yielding plants for continuous monitoring of these habitats. Moreover, the potentiality of the protected areas can also be judged based on the composition and richness of fodder yielding plants. Having all these in mind, we assessed the composition and conservation status of the fodder yielding plants of all habit forms from three recognized protected areas named Chunati Wildlife Sanctuary, Dudhpukuria-Dhopachari Wildlife Sanctuary, and Madhupur National Park. The study indicated the presence of 306 fodder yielding plant species of all habit forms in the three studied protected areas. This chapter describes the composition, status, habit forms, and nature of occurrences of the wild fodder yielding plants which is expected to be highly helpful in wildlife habitat monitoring and undertaking specific measures for multiplication and conservation of fodder yielding plants.
Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Aging is an irresistible natural law of the progressive decline of body molecules, organs, and overall function with the passage of time, resulting in eventual death. World Health Organization data show that aging is correlated with a wide range of common chronic diseases in the elderly, and is an essential driver of many diseases. Panax Ginseng C.A Meyer is an ancient herbal medicine, which has an effect of “long service, light weight, and longevity” recorded in the ancient Chinese medicine book “Compendium of Materia Medica.” Ginsenoside Rg2, the main active ingredient of ginseng, also exerts a marked effect on the treatment of liver injury. However, it remains unclear whether Rg2 has the potential to ameliorate aging-induced liver injury. Hence, exploring the hepatoprotective properties of Rg2 and its possible molecular mechanism by Senescence Accelerate Mouse Prone 8 (SAMP8) and gut microbiota. Our study demonstrated that Rg2 can inhibit pyroptosis and apoptosis through caspase 8, and regulate the gut-liver axis to alleviate liver inflammation by changing the composition of gut microbiota, thus improving aging-induced liver injury. These findings provide theoretical support for the pharmacological effects of ginsenosides in delaying aging-induced liver injury.
ORIGINAL ARTICLE Fibrinogen and von Willebrand factor-independent platelet

Field: Medicine (Health Sciences)

essential for platelet aggregation. However, we recently dem-onstrated formation of occlusive thrombi in Fg-deficient mice and in mice doubly deficient for Fg and von Willebrand factor (Fg/VWF)/)).Methods and results:Here we studied Fg/VWF-independent platelet aggregation in vitro and found no aggregation in citrated platelet-rich plasma of Fg/VWF)/) mice. Surprisingly, in Fg/VWF)/) plasma without anticoagu-lant, adenosine diphosphate induced robust aggregation of Fg/ VWF)/) platelets but not of b3-integrin-deficient (b3 platelets. In addition, b3)/) platelets did not significantly incorporate into thrombi in Fg/VWF)/) mice. This Fg/VWF-independent aggregation was blocked by thrombin inhibitors (heparin, hirudin, PPACK), and thrombin or thrombin receptor activation peptide (AYPGKF-NH2) induced aggrega-tion of gel-filtered Fg/VWF)/) platelets in 1 mM Ca2+ PIPES
TARI TAK OYAI DI KAMPUANG AIE DUKU KANAGARIAN PAINAN TIMUR “PEMARGINALAN DAN KEBERTAHANAN DALAM KONTEKS PELESTARIAN”

Field: Arts and Humanities (Social Sciences)

Tak Oyai dance is a cultural heritage of the community of Pesisir Selatan Regency, particularly Painan Timur. The research focused on Tak Oyai dance in the Aie Duku Village, where the dance is herited from their ancestors. This research used qualitative method; where data is collected by observation, interviews, and documentation using equipments such as video and audio recorder, also camera. Research findings prove that Tak Oyai dance is recognized as a cultural heritage in the social and cultural life of the community, however it is not recognized as the current tradition and culture of the Aie Duku community, therefore it is rarely presented in entertaining and ceremonial event. In the other hand there is still an attempt preserve the dance although not yet successful.
Bilateral congenital absence of flexor pollicis longus with thumb hypoplasia and thenar atrophy

Field: Medicine (Health Sciences)

Abstract Congenital absence of flexor pollicis longus with or without associated anomalies of thenar muscles and thumb is of rare occurrence. Inability to flex the interphalangeal joint of the thumb and absent dorsal wrinkles and flexion creases of the thumb are important clues to the diagnosis. Routine radiography and cross-sectional imaging help to confirm and document the condition. This article presents an extremely rare case of bilateral congenital absence of flexor pollicis longus tendon with thumb hypoplasia and thenar atrophy.
High-sensitivity dual-comb and cross-comb spectroscopy across the infrared using a widely tunable and free-running optical parametric oscillator

Field: Physics and Astronomy (Physical Sciences)

Dual-comb spectroscopy (DCS) enables high-resolution measurements at high speeds without the trade-off between resolution and update rate inherent to mechanical delay scanning. However, high complexity and limited sensitivity remain significant challenges for DCS systems. We address these via a wavelength-tunable dual-comb optical parametric oscillator (OPO) combined with an up-conversion detection method. The OPO is tunable from 1300-1670 nm (signal) and 2700-5000 nm (idler). Spatial multiplexing in both the laser and OPO cavities creates a near-common path arrangement, enabling comb-line-resolved measurements in free-running operation. The narrow instantaneous bandwidth results in high power per comb-line up to 160 μW in the mid-infrared. Through intra-cavity up-conversion based on cross-comb spectroscopy, we leverage these power levels while overcoming the sensitivity limitations of direct mid-infrared detection. This approach yields a high signal-to-noise ratio (50.2 dB Hz¹/²) and high dual-comb figure of merit (3.5 × 10⁸ Hz¹/²). This scheme enabled detecting ambient methane over a 3-meter path length in millisecond time scale.
Titration of lysine residues on adenine nucleotide translocase by fluorescamine induces permeability transition

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Chemical modification of primary amino groups of mitochondrial membrane proteins by the fluorescent probe fluorescamine induces non‐specific membrane permeabilisation. Titration of the lysine ϵ‐amino group promoted efflux of accumulated Ca 2+ , collapse of transmembrane potential and mitochondrial swelling. Ca 2+ release was inhibited by cyclosporin A. Considering the latter, we assumed that fluorescamine induces permeability transition. Carboxyatractyloside also inhibited the reaction. Using a polyclonal antibody for adenine nucleotide translocase, Western blot analysis showed that the carrier appeared labelled with the fluorescent probe. The results point out the importance of the ϵ‐amino group of lysine residues, located in the adenine nucleotide carrier, on the modulation of membrane permeability, since its blockage suffices to promote opening of the non‐specific nanopore.
Standardized uptake values and ratios on 68Ga-DOTATATE PET-computed tomography for normal organs and malignant lesions and their correlation with Krenning score in patients with metastatic neuroendocrine tumors

Field: Medicine (Health Sciences)

The aim was to estimate the physiological standardized uptake values (SUVs) on 68 Ga-DOTATATE PET-computed tomography (CT) in normal organs and metastatic tumor lesions (both standard and delayed), and correlating the uptake values and ratios with Krenning Scores (K-score) in patients with metastatic/advanced neuroendocrine tumors (NETs) undergoing PET-CT studies for their management work-up. A total of 32 patients of metastatic NET with 95 discrete tumor lesions were included in this analysis. These patients underwent standard whole-body PET-CT following injection of 2–3 mCi (74–111 MBq) of 68 Ga-DOTATATE at 1–1.5 h. The normal physiological SUVmean of the liver and spleen and SUVmax and SUVmean of tumor lesions were estimated by an in-built automated procedure. These patients also underwent a delayed scan (2.5–3 h) and the same parameters were obtained for the delayed study. The tumorous lesions were further classified on the basis of K-score, and this was correlated with the mean SUVmax on both early and delayed scans. SUVmean ratios (tumor-to-liver and tumor-to-spleen) were also calculated for both time-points and correlated with individual K-scores. In lesions with K-score 4, the mean SUVmax was 32.5 in early and 30.5 in delayed scan, for lesions with K-score of 3 and 2, the mean SUVmax were 17.3, 20, and 9.3, 9.2, respectively, while in K-score 1 ( n = 1), the delayed mean SUVmax was found to be more than early mean SUVmax (3.2 to 2.3). Statistical significance was evaluated by paired t test, and the changes in SUVmax was found to be statistically insignificant ( P > 0.05) in all 3 K-scores. The paired t test was also performed between early and delayed tumor/liver and tumor/spleen mean SUVmean ratios, and no significant changes were observed across all K scores. The mean SUVmean values of the liver in the standard 1-h scan and delayed scans were 8.05 (range: 3–15) and 8.17 (range: 3.2–16), while for spleen, the values were 18 (range: 8.4–36.7) and 20 (range: 10–38.6), respectively. Statistically significant changes were observed in delayed spleen SUVmean values compared to the early scan ( P < 0.05), while for liver SUVmean, the difference was not significant. Thus, in the present study, the SUVmax and SUVmean (range and mean values) for normal liver and spleen, and malignant NET lesions, and tumor-to-liver and tumor-to-spleen SUVmean ratios of different K-scores were generated. As could be theoretically expected in receptor-based PET-CT, there was no significant change in the delayed scan compared to the standard 1–1.5 h values
Creating the climate for design and technology in the primary classroom

Field: Social Sciences (Social Sciences)

This paper focuses on the role of the teacher in creating an effective climate for design and technology. In it\nI detail argument about necessary qualities of the role and explore how these understandings were gained\nthrough reflection on personal practice. I draw its findings from an extensive piece of research carried out\nin four schools over five years. Findings include commentary on teaching characteristics and teacher child\ninteractions.
Investigations to identify field isolates of the avian infectious bronchitis virus in chickens and their serological differentiation by means of the indirect immunoperoxidase test

Field: Veterinary (Health Sciences)

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