Immediate-Release and Sustained-Release Procainamide: Bioavailability at Steady State in Cardiac Patients

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Brief Reports1 May 1983Immediate-Release and Sustained-Release Procainamide: Bioavailability at Steady State in Cardiac PatientsPETER H. VLASSES, Pharm.D., MARIO L. ROCCI Jr., Ph.D., KAREN A. PORRINI, Pharm.D., ARNOLD J. GREENSPON, M.D., ROGER K. FERGUSON, M.D.PETER H. VLASSES, Pharm.D.Search for more papers by this author, MARIO L. ROCCI Jr., Ph.D.Search for more papers by this author, KAREN A. PORRINI, Pharm.D.Search for more papers by this author, ARNOLD J. GREENSPON, M.D.Search for more papers by this author, ROGER K. FERGUSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-613 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptProcainamide is effective in the prevention or treatment of various cardiac arrhythmias. Maintaining serum procainamide concentrations in the therapeutic range has been identified as an important factor in preventing the recurrence of cardiac arrest independent of suppression of ventricular ectopic activity (1). Because of its relatively short serum half-life, procainamide usually must be administered every 3 to 4 hours, at great inconvenience to the patient, in order to maintain effective serum concentrations and prevent excessive fluctuations above or below the therapeutic range (2). A recently marketed, sustained-release dosage form of procainamide, Procan-SR (Parke-Davis, Morris Plains, New Jersey), has been found...References1. MYERBURG R, CONDE C, and SHEPS D. Antiarrhythmic drug therapy in survivors of prehospital cardiac arrest: comparison of effects on chronic ventricular arrhythmias and recurrent cardiac arrest. Circulation. 1979;59:855-63. CrossrefMedlineGoogle Scholar2. KOCH-WESER J and KLEIN S. Procainamide dosage schedules, plasma concentrations and clinical effects. JAMA. 1971;215:1454-60. CrossrefMedlineGoogle Scholar3. SMITH T and KINKEL A. Plasma levels of procainamide after administration of conventional and sustained-release preparations. Curr Ther Res. 1980;27:217-28. Google Scholar4. LAI C, KAMATH B, LOOK Z, and YACOBI A. Determination of procainamide and N-acetylprocainamide in biological fluids by high-pressure liquid chromatography. J Pharm Sci. 1980;69:982-4. CrossrefMedlineGoogle Scholar5. ROCCI M and JUSKO W. LAGRAN program for area and moments in pharmacokinetic analysis. Comp Prog Biomed. 1983. (In press). CrossrefMedlineGoogle Scholar6. KUEHL P, ARQUIN P, and ERDAHL J. Steady-state bioavailability of a sustained-release procainamide preparation. Drug Intell Clin Pharm. 1982;16:475-6. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PETER H. VLASSES, Pharm.D.; MARIO L. ROCCIJr., Ph.D.; KAREN A. PORRINI, Pharm.D.; ARNOLD J. GREENSPON, M.D.; ROGER K. FERGUSON, M.D.Affiliations: Jefferson Medical College Thomas Jefferson University Hospital Philadelphia College of Pharmacy and Science Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical PharmacokineticsClinical Use of Class Ia Antiarrhythmic DrugsComparative Bioequivalence and Efficacy of Two Sustained-Release Procainamide Formulations in Patients with Cardiac ArrhythmiasPharmacokinetic/Pharmacodynamic Basis of Controlled Drug DeliveryExperience with Intrainstitutional Clinical Evaluations of Newly Marketed Preparations as a Basis for Drug-Product Selection to Hospital FormulariesAcademic-Industrial Clinical Pharmacology: A Working ModelProcainamide, Quinidine, Disopyramide, Cibenzoline, Pirmenol — Efficacy in the Treatment of Ventricular Arrhythmias: Current Status and ControversiesBioequivalency of Sustained-Release Procainamide 1 May 1983Volume 98, Issue 5_Part_1Page: 613-614KeywordsArrhythmiaAttentionClinical pharmacologyHalf lifeHeart ePublished: 1 December 2008 Issue Published: 1 May 1983 PDF downloadLoading ...