jimnoneill/paper-to-field-training huggingface dataset:
Väetamise mõju hariliku kuuse (Picea abies (L.) Karst) poogenditele Pauska seemlas / The effect of fertilization on Norway spruce (Picea abies (L.) Karst) grafts: a case study in Pauska seed orchard

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Altogether 197 grafts were studied in Pauska seed orchard in South-Estonia to find out the effect of the fertilization on Norway spruce grafts. The fertilization trials were carried out in May 1988 and 2006. The grafts of 4 different clones with 5 different fertilization treatments (N, P, K, NPK, control) were under study. The effect of three factors (fertilization, clone and year) on different characteristics of spruce grafts was studied. The linear methods with R software were used to find out relationships between variables. In addition to the morphological features and the content of nutrients in needles, the quantities and qualities of the mean cone and the weight of 1000 seeds were measured. Furthermore, the variation of quantities of needles (density, weight, length) and the content of nutrients in needles between years 1988 and 2007 were compared, using the linear methods with R software package. The morphological characteristics and nutrient content of needles, the mass of cones and seeds have depended the most on a calendar year. During the last research period (2003−2007), the needles of grafts under study were longer, lighter and with lower density compared to earlier research period (1988-1993). The effect of a clone was also essential. Needles of younger grafts were longer, heavier and set sparser than needles of older grafts. The needle nutrient content of younger grafts was also higher compared to the older ones. The effect of fertilizers on the grafts was dependent on the period of time. Nitrogen fertilizers increased the N-content in their needles during the first four years and also after repetitive fertilization. Phosphate fertilizers increased the P-content in their needles starting from the third year after their fertilization. The impact of potassium fertilizers on the K-content of their needles appeared 2−4 years after their fertilization. Combined fertilizers increased the N- and P-content in the needles to some extent, whereas it decreased their Ca- and Mg-content.
Hats Off to HIT: A Case Report

Field: Medicine (Health Sciences)

Thrombocytopenia is a well- recognized complication of heparin therapy. The diagnosis is mostly clinical and the main value of laboratory testing is in excluding the diagnosis. We describe here a patient with stroke who had aspiration pneumonia leading to sepsis. She developed atrial fibrillation and received heparin which had to be stopped prematurely due to melena. Within 5 days of heparin, she had thrombocytopenia which was heparin-induced thrombocytopenia (HIT), but the diagnosis was missed initially as heparin was no longer on the drug chart.
CBMT-05. ROLE OF THE let7-eEF2K AXIS IN MYC-DRIVEN MEDULLOBLASTOMA ADAPTATION TO NUTRIENT DEPRIVATION

Field: Medicine (Health Sciences)

BACKGROUND/OBJECTIVES: MYC amplification in medulloblastoma (MB) determines highly aggressive disease, underscoring an urgent need for novel therapies. Let-7 microRNAs (miRNAs) inhibit tumor progression and regulate metabolism by degrading several mRNAs, including MYC. Let-7 miRNAs are frequently repressed in cancer, including MYC-driven MB. We previously reported that eukaryotic Elongation Factor-2 Kinase (eEF2K) is a pivotal regulator of MYC-driven tumor adaptation to nutrient deprivation (ND). Our data indicate that the eEF2K 3’ untranslated region (UTR) harbors a potential binding site for let-7. In addition, eEF2K mRNA and let-7 miRNA expression negatively correlates in MB, suggesting regulation of the former by the latter. We therefore hypothesized that let-7 down-regulation induces eEF2K expression in MB, thereby supporting MYC-driven MB adaptation to ND and tumor progression. METHODS: Immunohistochemistry for eEF2K substrate (p-eEF2) was performed on MB tissue microarrays to link results with MYC expression and clinical outcome. Effects of eEF2K pharmacological inhibition on MB cell survival were evaluated in vitro by MTT assays. The ability of let-7 to degrade eEF2K mRNA was assessed by let-7 miRNAs transfection into MB cells, followed by RT-PCR and Western Blotting for eEF2K. Binding of let-7 to the eEF2K 3’UTR was validated by luciferase reporter assays. RESULTS: High eEF2K activity is linked to MYC over-expression and reduced survival in MB (p<0.05). Pharmacological inhibition of eEF2K significantly reduces survival of MYC-amplified MB cell lines under ND. Transfection let-7 miRNAs decreases eEF2K mRNA and protein levels (by ~40–50%) in MB cells. Down-regulation of luciferase activity by let-7 miRNAs is impaired upon mutation of the let-7 binding site on the eEF2K 3’UTR. CONCLUSIONS: Let-7 miRNAs degrade eEF2K mRNA, indicating that let-7 repression in MYC-driven MB is partially responsible for eEF2K increased levels and activity. Moreover, the let-7-eEF2K axis represents a critical mechanism for MYC-driven MB adaptation to ND, constituting a promising therapeutic target.
Processes in Microbial Ecology

Field: Immunology and Microbiology (Life Sciences)

Abstract Processes in Microbial Ecology discusses the major processes carried out by viruses, bacteria, fungi, protozoa, and other protists—the microbes—in freshwater, marine, and terrestrial ecosystems. The book shows how advances in genomic and other molecular approaches have uncovered the incredible diversity of microbes in natural environments and unraveled complex biogeochemical processes carried out by uncultivated bacteria, archaea, and fungi. The microbes and biogeochemical processes are affected by ecological interactions, including competition for limiting nutrients, viral lysis, and predation by protists in soils and aquatic habitats. The book links up processes occurring at the micron scale to events happening at the global scale, including the carbon cycle and its connection to climate change issues. The book ends with a chapter devoted to symbiosis and other relationships between microbes and large organisms, which have large impacts not only on biogeochemical cycles, but also on the ecology and evolution of large organisms, including Homo sapiens.
Be strong, be confident: the rise of China and the 2022 Beijing Winter Games

Field: Social Sciences (Social Sciences)

Drawing on promotional materials in 2007-2008 and in 2021-2022, this article examines both Olympics to explore how the state has evolved in its governmental rationalities, and the related cultural and political implications. The 2022 Winter Games, despite its comparatively low profile and challenges posed by Covid-19, provided the Chinese state with a key moment to advance its confidence doctrine. Three discourses were mobilised pertaining to, first, the CCP's superb leadership and problem-solving skills; second, China's mega-infrastructure; and, third, created + made in China. The 2022 Olympics thus mobilised three confidence-driven discourses: leadership confidence, techno-scientific confidence, and creative confidence. In doing so, the 2022 Olympics envisioned, narrated, and materialised the popular discursive signifiers - technology, green and sustainability, and the future - the authorities already actively promoted in its political initiatives and policies. This contributed to the inward-oriented beliefs of self-reliance and self-improvement. Where we witnessed in 2008 a sense of curiosity and openness, within China and the world at large, we now face the complexities, dangers, and cultural essentialism, if not narcissism, of a confident China.
Extensive ileocaval and renal vein thrombosis mimicking acute pyelonephritis

Field: Medicine (Health Sciences)

Renal vein thrombosis (RVT) is a rare clinical diagnosis which is the presence of thrombus in the major renal veins or its tributaries. Major causes include nephrotic syndrome, trauma, malignancy, hypercoagulable states. Presentation could be unilateral or bilateral flank pain and/or haematuria. Symptoms could be confused with nephrolithiasis. A normal ultrasonography (USG) in the initial stage could delay the diagnosis and hence propensity for dreaded complications such as loss of renal function and pulmonary embolism. Anticoagulation is the mainstay of therapy for RVT. Review of the literature reveals that thrombolytic therapy can also be used in patients with the most severe disease. Here we present a case of a young male, who initially suspected to have acute pyelonephritis, turned out to have extensive Iliocaval and unilateral RVT secondary to factor V leiden mutation who underwent catheter directed thrombolysis and mechanical thrombectomy.
The Effect of Compensation and Employee Empowerment on Employee Loyalty through Job Satisfaction as an Intervening Variable (Study at Perpustakaan Nasional RI)

Field: Business, Management and Accounting (Social Sciences)

This study aims to determine the influence of compensation and employee empowerment on employee loyalty through job satisfaction as an intervening variable. The research sample consisted of 113 employees of the National Library of Indonesia who worked in the Planning and Finance Bureau, the Legal, Organization, Cooperation, and Public Relations Bureau, the Human Resources and General Affairs Bureau, and the Central Education and Training Unit. The method used is a survey method with a quantitative approach. The sampling technique in this study uses Probability Sampling with the Taro Yamane formula and a 5% error rate. In hypothesis testing, the data analysis technique used is Structural Equation Modeling Partial Least Square (SEM-PLS) using SmartPLS Version 4.0 software. The results of the calculations in this study indicate that compensation has a positive and significant direct effect on employee loyalty, employee empowerment does not have a significant and negative direct effect on employee loyalty, job satisfaction has a positive and significant direct effect on employee loyalty, compensation has a positive and significant direct effect on job satisfaction, employee empowerment has a positive and significant direct effect on job satisfaction, compensation has a positive and significant indirect effect on employee loyalty through job satisfaction, and employee empowerment has a positive and significant indirect effect on employee loyalty through job satisfaction.
ContiSim TM : Process and Material Modelling of Continuous Casting in Macro and Micro Scale

Field: Engineering (Physical Sciences)

ContiSimTM is a systematically modular software built on more than 16 years of experience in the field of modelling of continuous casting processes [1]. It is focused on the coupled computation of solidification, cooling, phase change, contraction and stress evolution during the continuous casting of metals, the material bandwidth is from nonferrous metals like copper alloys to steel and cast iron. It allows to describe and to check existent or planned configurations virtually, to optimize operating conditions by parameter investigation, to determine crucial process states to develop measures for safe production, and to predict (and to control) interim and final product qualities. The special quality of computer simulation is to visualize even not measurable inner states and product qualities as well as to make understandable temporal sequences.
Managing Irrigation Risk with Inflow-Based Derivatives: The Case of Rio Mayo Irrigation District in Sonora, Mexico

Field: Economics, Econometrics and Finance (Social Sciences)

Uncertain reservoir inflows represent a major source of risk for irrigated agriculture. A derivative instrument that uses reservoir inflows as the underlying variable is designed and tested with a recursive stochastic simulation of the Rio Mayo irrigations system. The results indicate that the instrument effectively protects against downside risk.
Reverse phase high pressure liquid chromatographic separation of permethylated free and glucosylated gibberellins: A method for the analysis of gibberellin metabolites

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract A new strategy for simultaneous analysis of both free gibberellins (GAs) and gibberellin‐O‐glucosides (GA‐O‐glucosides) in plant extracts is described. The procedure, which avoids liquid‐liquid partitioning comprises the following sequential steps, applied to the aqueous residue of an 80% aqueous methanol extract: (a) ion exchange chromatography; (b) permethylation; (c) silica gel chromatography; (d) preparative reverse phase high pressure liquid chromatography; (e) gas chromatography‐mass spectrometry. The method has been used to analyse the acidic metabolites of [17‐ 2 H 2 ]GA 20 , applied to normal and dwarf‐1 Zea mays. In normal plants the label was found to be incorporated into GA 29 , GA 1 , GA 8 , GA 20 ‐13‐O‐glucoside, GA 29 ‐2‐O‐glucoside, GA 29 ‐13‐O‐glucoside, and GA 8 ‐2‐O‐glucoside. In dwarf‐1 mutant plants the label was incorporated into GA 29 , GA 20 ‐13‐O‐glucoside, and GA 29 ‐2‐O‐glucoside.
The intake procedures of child sexual abuse cases at Mafikeng Service Point of the Department of Health and Social Development

Field: Social Sciences (Social Sciences)

Due to the legal obligation to report actual or suspected cases of child sexual abuse
and neglect, parents, concerned community members and friends, as well as various
professionals like teachers, doctors and psychologists, refer children on a daily basis
to social workers in order to initiate an investigation of the allegations. The intake
interview is therefore a critical step in the process of child protection and care. In the
context of this study, intake interview refers to the initial contact between the social
worker and the child in the case of child sexual abuse, where a social worker seeks
to establish all objective facts relating to the case so as to make informed decisions
and to act accordingly.
The Mafikeng Service Point of the Department of Health and Social Development
has no standard procedures for social workers in cases of child sexual abuse. It is
against this background that a North West based study on the child sexual abuse
intake procedures was conducted at Mafikeng Service Point. The study was
descriptive and quantitative in nature, with the aim of making a theoretical as well as
an empirical study of the intake procedures at the time of the investigation. Data
was collected by means of a self–administered questionnaire on the current intake
procedures of 30 social workers. Data was triangulated by analysing 15 case files of
reported child sexual abuse.
It was found that the majority of social workers of the Mafikeng Service Point lack
sufficient knowledge and skills regarding interviewing child sexual abuse cases and
the legal requirements involved. As a result, they follow diverse and largely
inefficient intake interview procedures. The 15 case files that were analysed
revealed that social workers do not perform follow–up sessions after the intake and
that case files are therefore not officially closed. Recommendations are made to the
Mafikeng Service Point with regard to the intake procedures of child sexual abuse
cases.
Outcomes and factors impacting use of axicabtagene ciloleucel in patients with relapsed or refractory large B-cell lymphoma: results from an intention-to-treat analysis

Field: Medicine (Health Sciences)

Data on real-world outcomes of axicabtagene ciloleucel (axi-cel) therapy for relapsed/refractory large B-cell lymphoma (R/R LBCL) are limited. In this intent to treat (ITT) analysis, we reviewed records of 38 consecutive patients with R/R LBCL for whom axi-cel was intended. Twenty-seven (71%) patients received axi-cel and 11 (29%) did not. Patients in the non-axi-cel group had a higher hematopoietic cell transplantation comorbidity index (HCT-CI) (median 4 vs. 2, p = .04). Median overall survival for the ITT, axi-cel and non-axi-cel group was 10 (95% CI, 3.7 to 13), 13 (95% CI, 7.7 to N.R.) and 1 (95% CI, 0.4 to 3.7) month(s) respectively. Factors limiting axi-cel use were disease progression, sepsis, manufacturing failure and socioeconomic barrier in 6 (55%), 3 (27%), 1 (9%) and 1 (9%) patient(s) respectively. Additional strategies are needed to ensure all LBCL patients for whom chimeric antigen receptor (CAR) T-cell therapy is prescribed can receive this treatment.
The Chagres River Route to California in 1851

Field: Arts and Humanities (Social Sciences)

Research Article| March 01 1929 The Chagres River Route to California in 1851 Georgia Willis Read Georgia Willis Read Search for other works by this author on: This Site PubMed Google Scholar California Historical Society Quarterly (1929) 8 (1): 3–16. https://doi.org/10.2307/25177981 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Georgia Willis Read; The Chagres River Route to California in 1851. California Historical Society Quarterly 1 March 1929; 8 (1): 3–16. doi: https://doi.org/10.2307/25177981 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentCalifornia History Search This content is only available via PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
[Suprasegmental effects of selective posterior rhizotomy].

Field: Medicine (Health Sciences)

The occurrence of spasticity is most commonly attributed to the lack of presynaptic inhibition. Perinatal damage to the central nervous system, as it happens in cerebral palsy, leads to pathological reflex response both on segmental and polysegmental levels. It results not only in clinical signs typical for spasticity but also in alterations of brainstem function, such as dysarthria or congenital nystagmus. Selective posterior rhizotomy is a neurosurgical method, routinely used in the treatment of spasticity. The lumbosacral posterior roots are partially cut under perioperative neurophysiological control. The aim of the treatment is the reduction of afferentation for posterior horns resulting in a decrease of pathological reflex responses. Selective posterior rhizotomy consequently decreases lower limbs spasticity. The improvement of upper extremities fine skills, the improvement of speech and cognitive functions has been also observed after selective posterior rhizotomy. The possible pathophysiological explanations of these so-called suprasegmental effects are discussed in the article.
Farm Risk Management Between Normal Business Risk and Climatic/Market Shocks

Field: Arts and Humanities (Social Sciences)

Farm risk management for income stabilization is on-going issue. An applied work has been performed to measure farm risk using a stochastic model. Risk management tools, with symmetric as well as asymmetric impacts, are then tested and compared through ad hoc statistics. Normal farm business risk can be efficiently managed using a precautionary saving provision. Farm revenue insurance is found as the most efficient asymmetric tool for dealing with climatic and market shocks. The linkage between these complementary tools can be adjusted upon market environment.
PROGRAM PENGABDIAN: SOSIALIASI BAHAYA KEBAKARAN MENGGUNAKAN PROTOTYPE ALAT BERBASIS IoT UNTUK WARGA HINTERLAND BATAM

Field: Health Professions (Health Sciences)

<p><strong><em>Abstract.</em></strong> <em>The dry season is starting to be felt in Batam and brings the threat of drought. This dry or hot season has an impact in the form of the threat of protected forest fires in the Rempang and Galang Island areas, Batam. Residents of Pasir Panjang at the end of last month a fire accident occurred in the residential area of the village. This has made residents wary of fires. The development of technology is currently increasing rapidly with the existence of the Internet of Thing (IOT) which is one of the solutions to problems in daily activities, including in handling fires. The purpose of this service is to try to make an application for fire detection in the residential area. The method of implementation is carried out in stages, needs analysis, training and mentoring programs, handing over of tools and evaluation of activities. The results of this service are in the form of a prototype IoT application product. Another result is from training in the form of socialization of fire hazard prevention by demonstrating a tool with a very good and enthusiastic response from the community based on an average rating scale above 4.</em><em></em></p><p><strong><em> </em></strong></p><p><strong>Abstrak.</strong> Musim kemarau mulai terasa di Batam dan membawa ancaman kekeringan. Musim kemarau atau panas ini menimbulkan dampak berupa ancaman kebakaran hutan lindung di kawasan Pulau Rempang dan Galang, Batam. Warga Pasir Panjang akhir bulan lalu terjadi musibah kebakaran yang menimpa di kawasan perkampungan tempat tinggal. Hal ini membuat warga was-was terhadap bancana kebakaran. Perkembangan teknologi saat ini semakin pesat dengan adanya Internet of Thing (IOT) menjadi salah satu pemecahan masalah dalam aktifitas sehari-hari, tak terkecuali dalam penanganan kebakaran. Tujuan dari pengabdian ini adalah mencoba membuat suatu aplikasi untuk pendeteksi kebakaran di daerah perkampungan tempat tinggal. Metode pelaksanaan dilakukan secara bertahap analisa kebutuhan, program pelatihan dan pendampingan, penyerahan alat dan evaluasi kegiatan. Hasil pengabdian berupa produk prototype aplikasi IoT. Hasil lain yakni dari pelatihan berupa sosialisasi pencegahan bahaya kebakaran dengan memperagakan alat dengan respon masyarakat sangat baik dan antusias berdasarkan rata2 penilaian skala diatas 4.<strong></strong></p><p class="5ComdevIsiAbstrakIndo"> </p><div id="gtx-trans" style="position: absolute; left: 319px; top: 370px;"> </div>
Focal adhesion kinase promotes phospholipase C-γ1 activity

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The nonreceptor tyrosine kinase FAK (“focal adhesion kinase”) is a key mediator of integrin signaling events controlling cellular responses to the extracellular matrix, including spreading, migration, proliferation, and survival. Integrin-ligand interactions stimulate FAK tyrosine phosphorylation and activation of FAK signaling functions. Here evidence is presented that the FAK autophosphorylation site Tyr-397 mediates a direct interaction with the C-terminal Src homology 2 domain of phospholipase C (PLC)-γ1 and that this is required for both adhesion-dependent association of the two molecules and increased inositol phosphate production in mouse embryo fibroblasts. Overexpression of FAK and PLC-γ1 in COS-7 cells increases PLC-γ1 enzymatic activity and tyrosine phosphorylation, also dependent on FAK Tyr-397. However, FAK appears incapable of directly phosphorylating PLC-γ1. These observations suggest a role for FAK in recruiting PLC-γ1 to the plasma membrane at sites of cell-matrix adhesion and there promoting its enzymatic activity, possibly by releasing the repression caused by intramolecular interactions of the PLC-γ1 Src homology domains and/or by positioning it for phosphorylation by associated Src-family kinases. These findings expand the known signaling functions of FAK and provide mechanistic insight into integrin-stimulation of PLC-γ1.