jimnoneill/paper-to-field-training huggingface dataset:
Immunogenicity and Efficacy Evaluation of Vero Cell-Adapted Infectious Bursal Disease Virus LC-75 Vaccine Strain in Ethiopia&nbsp;

Field: Veterinary (Health Sciences)

Abstract

Background: Infectious bursal disease virus (IBDV) is an avian viral pathogen that causes infectious bursal disease (IBD) of chickens. The disease is endemic in Ethiopia since 2002 and vaccination is the major means of disease prevention and control. IBD vaccine is produced in Ethiopia using primary chicken embryo fibroblast (CEF) cell; which is time-consuming, laborious, and uneconomical. The present study was carried out to develop cell-based IBDV LC-75 vaccine using Vero cells, and to evaluate the immunogenicity and protection level.Results: Identity of the vaccine seed was confirmed using gene-specific primers using reverse transcription polymerase chain reaction. Confluent monolayer of Vero cells was infected with vaccine virus and serial passage continued till passage ten. Characteristic virus induced cytopathic effect was observed starting from passage 2 on the third day post-infection. The infectious titer of adapted virus showed a linear increment along the passage level. Virus induced specific antibody was determined using indirect ELISA after vaccination of 14 days old chicks through ocular route. Accordingly, the antibody titer measured from Vero cells vaccinated chicks revealed similar level with the currently available CEF cell-based vaccine. Chicks vaccinated with Vero cell adapted virus showed complete protection against very virulent IBDV, while unvaccinated group had 60% morbidity and 25% mortality.Conclusions: The IBDV vaccine strain well adapted on Vero cells and found to be immunogenic induces antibodies development and successfully protects chicks against challenging with the circulating field IBDV isolate. Hence, it is recommended to produce IBD vaccine using Vero cell culture with enough quantity to conquer the limitations using CEF cells and thus to vaccinate chicks to protect against IBDV infection.
[A computerized endurance test: efficacy of pelvic floor rehabilitation treatment in patients with stress incontinence].

Field: Health Professions (Health Sciences)

In the present study the authors wanted to transfer rigorous methods of study, already in use in other sectors (sports, medicine, isokinetic work, etc.) of the validity of interventions made and their effectiveness, into an "emerging" field, that of perineal rehabilitation. 15 female patients, aged between 35 and 45, affected by stress incontinence underwent a baseline clinico-instrumental evaluation of the perineal floor including a computerized test of endurance. The patients then embarked upon a standardized rehabilitative perineal training lasting a month and at the end underwent an identical evaluation as that performed at the outset. Statistical analysis of the results obtained showed an objective improvement in the parameters considered (endovaginal pressure and its variations during a series of intermittent static contractions) quantitatively supporting clinical evidence.
ZjuMatrix: C++ vector and matrix class library for finite element method

Field: Computer Science (Physical Sciences)

Finite element analysis is an indispensable and valuable tool widely used in the field of science and technology. It involves a multitude of matrix operations, storage of large banded matrices, and calculation of large-scale algebraic equations and associated eigenvalue problems. To facilitate these computations, a static library ZjuMatrix is developed based on the object-oriented design techniques and leverages the power of the C++ programming language. ZjuMatrix provides a comprehensive set of vector and matrix classes, offering efficient data storage management. The library supports various matrix types, including general matrices, square matrices, symmetric matrices, and symmetric banded matrices. Essential matrix operations such as addition, subtraction and multiplication are implemented. Furthermore, ZjuMatrix also offers advanced functionalities including LU factorization of a square matrix, LDL factorization of a symmetric positive definite matrix, determinant and inverse of a square matrix. In addition, ZjuMatrix equips researchers with methods to solve the standard eigenvalue problem of symmetric matrices and generalized eigenvalue problems of symmetric banded matrices. This robust support system lays a solid foundation for the implementation of the structural finite element analysis.
uPAR is regulated via miR-561-3p and affects the progression and aggressiveness of CRC cells via the PI3K/AKT signaling pathway

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Urokinase plasminogen activator (uPA), the uPA receptor (uPAR) and plasminogen activator inhibitor type 1, constitute the plasminogen urokinase activation system that is hypothesized to be associated with the malignant biology of cancer cells. However, the regulation mechanism of uPAR expression in colorectal cancer (CRC) remains unclear. In the present study it was demonstrated that uPAR was upregulated in serum samples from patients with CRC and uPAR expression levels were associated with advanced stages of CRC and distant metastasis in patients. In CRC cells, uPAR was demonstrated to promote cell proliferation, migration and invasion, but inhibited cell apoptosis. Furthermore, the results demonstrated that uPAR expression was negatively regulated via miR-561-3p, via the binding of miR-561-3p to its 3’-untranslated region. Moreover, uPAR reduced the activation of the PI3K/AKT signaling pathway. In conclusion, uPAR was downregulated via miR-561-3p and potentially contributed to tumorigenesis via the PI3K/AKT signaling pathway in CRC.
Graphene Oxide Synthesized Using Mild Reduction Method Improved the Anti-Tumor Efficacy on Human Cervical Cancer

Field: Materials Science (Physical Sciences)

In the current study, graphene oxide (GO) as raw material synthesized using different reduction degrees prepared by a mild method. We used Fourier transform infrared spectroscopy (FTIR), Raman Spectroscopy (Raman), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible spectroscopy (UV-Vis), transmission electron microscopy (TEM) and EDS spectroscopy to characterize its structure and morphology. The results of cell experiments showed the significant cytotoxicity activity of reduced GO under laser irradiation. In addition, reduced GO kills tumor cells through the dual effects of photothermal and phototoxicity under near-infrared (NIR) laser irradiation and can be used as photothermal therapy
Student Evaluation of Learning Environments

Field: Social Sciences (Social Sciences)

There have been many attempts to evaluate the teaching-learning environment. One important direc tion is the evaluation of the effect of different methods upon learning. Dubin and Taveggia (4) reana lyzed the data from studies conducted between 1924 and 1965, and conclude that research comparing differ ent methods finds no significant differences among them when student learning is assessed through final exams. Similar conclusions are supported by the re sults of Baker and Behrens (2) in non-examination environ ments. McGee (5) summarizes the implications of these studies, as well as his own research on the significance of the process, for student learning. Teaching meth ods are irrelevent to learning; teaching techniques don't teach, teachers (5). Furthermore, he argues: . . . that it is quite possible that teachers do not really teach students as conventionally under stood at all, that is, that most teacher in-puts in the classroom are relatively unrelated to student out-takes and that, in essence, students teach themselves. This does not mean that I believe that the presence, conduct and person of the teacher are either irrelevant or dispensable. Only that they are different from conventional and implicitly understood models and that if we really wish to improve the quality of college teaching, we need different and more realistic paradigms of the teaching-learning process. (5)
Synergy of Valence Band Modulation and Grain Boundary Engineering Leading to Improved Thermoelectric Performance in SnTe

Field: Materials Science (Physical Sciences)

SnTe is a lead-free and promising p-type thermoelectric material in an intermediate temperature range (500–900 K), but its intrinsic performance is poor due to excess cation vacancies and relatively large band offset between L and ∑ valence bands. In this study, we alloyed Sb2Te3 into the SnTe matrix and successfully promoted the valence band convergence as supported by the calculated two-band Pisarenko curve; we further doped excess Mg and obtained a significantly reduced lattice thermal conductivity ∼0.44 W m–1 K–1 at 623 K. Scanning transmission electron microscopy (STEM) reveals that a large amount of Mg-rich nanoprecipitates concentrate at SnTe grain boundaries and stay coherent with the SnTe lattice, which is believed to be responsible for the large reduction of lattice thermal conductivity. Through the synergetic effects of valence band modulation and grain boundary engineering, a decent ZTmax of ∼1.14 at 723 K and an impressively large ZTavg of ∼0.67 (323–773 K) were achieved simultaneously in the (Sn0.95Mg0.05Te)10Sb2Te3 sample.
Effect of Diane-35 on Adolescent Dysfunctional Uterine Bleeding

Field: Medicine (Health Sciences)

Objective To probe into the clinical effect of Diane-35 on adolescent dysfunctional uterine bleeding.Methods Sixty-five cases of adolescent dysfunctional uterine bleeding were randomized into control group(34 cases)and observation group(31cases).Control group was treated with conjugated estrogen tablets and treatment group with Diane-35.Results After treatment ,the effect on controlling bleeding and time of complete bleeding stopping in observation group was superior to that in control group(P0.05),and the bleeding stopping rate(100%)was superior to that of control group(P0.05).Conclusion Diane-35 has a significant therapeutic effect on adolescent dysfunctional uterine bleeding and stops bleeding rapidly,with convenient administration and less side effect ,and is apt to be accepted by patients.
Law and Politics: Rumours of the Demise of the Lord Chancellor have been Exaggerated ...

Field: Social Sciences (Social Sciences)

Not surprisingly, the war in Iraq and the ‘war on terror’ have set the agenda for many of the developments in law and politics during 2004. There have been major conflicts between the government and the courts on legislation intended to protect society from terrorists. There have also been major developments on the domestic front. The announcement of the demise of the office of Lord Chancellor and its replacement by a Secretary of State for Constitutional Affairs in June 2003 was proved to be premature, following pressure from the House of Lords in the autumn. However, plans for a new Supreme Court made progress after a Concordat was agreed between the government and senior members of the judiciary. Hunting again provoked much controversy, with the Hunting Bill eventually passing through use of the Parliament Acts; it promises some interesting legal challenges in 2005.
Universal Potential Model in Tied and Separated Double-Gate MOSFETs With Consideration of Symmetric and Asymmetric Structure

Field: Engineering (Physical Sciences)

A universal compact potential model for all types of double-gate MOSFETs is presented. An analytical closed-form solution to a 2D Poisson's equation is obtained with the approximation that a vertical channel potential distribution is a cubic function of position. As a result, an analytical equation for the threshold voltage is derived from the proposed potential model. Different gate work functions and independent gate biases for front and back gates are considered, and the proposed model is found to be valid for an arbitrary double-gate structure: a symmetric versus asymmetric double gate and a tied versus separated double-gate structure. The threshold voltage behaviors for double-gate MOSFETs are investigated for various device dimensions. The back-gate effects of the separated double gate are also investigated for various silicon channel thicknesses and gate oxide thicknesses. Last, a process-induced threshold voltage fluctuation is estimated for symmetric and asymmetric separated double-gate MOSFETs. The analytical solution of the threshold voltages is verified by a comparison with simulation results in terms of the gate length, the silicon thickness, and the gate oxide thickness. A good agreement between two sets of results is obtained.
Design of a drop test machine capable of testing electronics up to 20000g’s

Field: Engineering (Physical Sciences)

In this project, the author and her partner are expected to review the system and the working principle of the current shock test machines and patents. Having the knowledge and understanding of the current design and patents, the author is projected to design a shock test machine that is able to generate a half sine shock up to 20,000G meter per second square in 5 millisecond. The device targeted to test military electronics weighting 2 kilograms. Given the specific requirement for the shock test machine, many considerations have been contributed during the project. Due to the high cost and limited resource of parts available, the project aim has been altered to design a shock test machine with acceleration level lower than 20,000 g’s. The whole report covered the examination of the current models and followed by generating the author and her partner’s idea in designing the shock test machine. Calculation in every single parts of the shock test machine with supported drawings are given to get the whole understanding of the shock test machine system. Some analysis by simulation of 2D Working Model and ANSYS are also shown as a proof of the capacity of the design. Even though the complete design has been generated, there are still a lot of spaces for improvement of the shock test machine.
Direct Visualization\nof the Self-Alignment Process\nfor Nanostructured Block Copolymer Thin Films by Transmission Electron\nMicroscopy

Field: Materials Science (Physical Sciences)

Herein, this work aims to directly visualize the morphological\nevolution of the controlled self-assembly of star-block polystyrene-<i>block</i>-polydimethylsiloxane (PS-<i>b</i>-PDMS)\nthin films via in situ transmission electron microscopy (TEM) observations.\nWith an environmental chip, possessing a built-in metal wire-based\nmicroheater fabricated by the microelectromechanical system (MEMS)\ntechnique, in situ TEM observations can be conducted under low-dose\nconditions to investigate the development of film-spanning perpendicular\ncylinders in the block copolymer (BCP) thin films via a self-alignment\nprocess. Owing to the free-standing condition, a symmetric condition\nof the BCP thin films can be formed for thermal annealing under vacuum\nwith neutral air surface, whereas an asymmetric condition can be formed\nby an air plasma treatment on one side of the thin film that creates\nan end-capped neutral layer. A systematic comparison of the time-resolved\nself-alignment process in the symmetric and asymmetric conditions\ncan be carried out, giving comprehensive insights for the self-alignment\nprocess via the nucleation and growth mechanism.
Bioinspired Diversification Approach Toward the Total Synthesis of Lycodine-Type Alkaloids

Field: Chemistry (Physical Sciences)

Nitrogen heterocycles (azacycles) are common structural motifs in numerous pharmaceuticals, agrochemicals, and natural products. Many powerful methods have been developed and continue to be advanced for the selective installation and modification of nitrogen heterocycles through C-H functionalization and C-C cleavage approaches, revealing new strategies for the synthesis of targets containing these structural entities. Here, we report the first total syntheses of the lycodine-type Lycopodium alkaloids casuarinine H, lycoplatyrine B, lycoplatyrine A, and lycopladine F as well as the total synthesis of 8,15-dihydrohuperzine A through bioinspired late-stage diversification of a readily accessible common precursor, N-desmethyl-β-obscurine. Key steps in the syntheses include oxidative C-C bond cleavage of a piperidine ring in the core structure of the obscurine intermediate and site-selective C-H borylation of a pyridine nucleus to enable cross-coupling reactions.
Analyzing Sliding Stability of Structures Using the Computer Program GWALL.

Field: Engineering (Physical Sciences)

This report documents the usage of the computer program GWALL to analyze the sliding stability of structures. The program provides for display of input data for easy checking and editing and requires the use of a Tektronix 4014 or other terminals with same capabilities. The analysis is a wedge method slope-stability analysis that follows the design procedures used in the Lower Mississippi Valley Division for analysis of plane failures. The program provides for calculation of uplift by entering profile of force water seepage pressures. (Author)
Reactions of Fluoroölefins with Sulfur Trioxide

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Fluoroölefins with Sulfur TrioxideD. C. England, M. A. Dietrich, and R. V. Lindsey Jr.Cite this: J. Am. Chem. Soc. 1960, 82, 23, 6181–6188Publication Date (Print):December 1, 1960Publication History Published online1 May 2002Published inissue 1 December 1960https://pubs.acs.org/doi/10.1021/ja01508a051https://doi.org/10.1021/ja01508a051research-articleACS PublicationsRequest reuse permissionsArticle Views1014Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Tables and Figures from Development and Validation of a Gene Signature for Patients with Head and Neck Carcinomas Treated by Postoperative Radio(chemo)therapy

Field: Medicine (Health Sciences)

<p>Table S1 Analyzed genes of the hypothesis-driven gene set. Table S2 Programs and packages used for evaluation. Figure S1 Results of repeated 3-fold cross validation for LRC. Figure S2 Mean oob ci depending of the signature size for LRC. Figure S3 Importance score for genes associated with LRC. Table S3 Increasing robustness by including highly correlated genes. Figure S4 Patient stratification by the 7-gene signature for LRC. Figure S5 Patient stratification by the 7-gene signature and clinical parameters for LRC. Table S4 Multivariable Cox regression of OS. Figure S6 Patient stratification by the 7-gene signature and clinical parameters for OS. Table S5 Multivariable Cox regression of DM. Figure S7 Patient stratification by the 7-gene signature and clinical parameters for DM. Table S6 Means and standard deviations of the 7-gene signature gene expressions. Table S7 Comparison of gene expressions between patient groups. Table S8 Hyper-parameters for feature selection algorithms and predictive models. Table S9 Patient characteristics of all patients. Figure S8 Identification of the final gene signature.</p>
Use of Anatomage tables in a large first year core unit

Field: Health Professions (Health Sciences)

Anatomage tables were incorporated into a large core unit in health sciences at Curtin University to replace cadaver material. Students worked in groups of eight around the table, as one of several stations in weekly workshops facilitated by tutors. Tutors and students completed a survey asking about their use of technology and their experiences with the Anatomage tables. Tutors also contributed to focus groups (n=16), and student interaction around the table was recorded on camera. Student survey response was 18% (n= 326) and for tutors, 69% (n=22). Preliminary analysis suggests that most students found the Anatomage tables good for ideas of scale and relationships of organ structures, and liked being able to rotate the images, but were less impressed with graphics quality and the limitations to group interaction. Tutors felt well-prepared for using the tables but were frustrated by technical issues, and few thought the tables were a good investment.
Transcription regulation by nuclear receptors: structure-function relationships

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Conference Abstract| October 01 2000 Transcription regulation by nuclear receptors: structure-function relationships Dino MORAS Dino MORAS 1UPR9004/CNRS - 1GBMC - 1, rue L. Fries - 67400 ILLKIRCH - FRANCE Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (5): A105. https://doi.org/10.1042/bst028a105c Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Dino MORAS; Transcription regulation by nuclear receptors: structure-function relationships. Biochem Soc Trans 1 October 2000; 28 (5): A105. doi: https://doi.org/10.1042/bst028a105c Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
A positive theory of privatization for developing countries: on Jean Jacques Laffont's last lectures

Field: Economics, Econometrics and Finance (Social Sciences)

According to his posthumous book, Laffont (2005), suggests that when policy-makers in less developed countries have a private agenda, regulators risk to be corrupted, and ex post evaluation is costly, government privatization supply is a non linear (inverted U) function of a corruption index. Both benevolent and very corrupted governments may divest State Owned Enterprises for very different reasons. Governments with an intermediate degree of corruption may like privatization, but not always for good reasons in terms of social welfare. Undesirable privatization occurs when the private benefit/cost ratio of the policy-makers exceeds the social value of divestiture. The paper restates the complex Laffont's model in a simplified, intuitive form. Then, some assumptions of the model are critically examined. Finally, empirical evidence is discussed, and found not entirely convincing, because of the modest impact of the negative quadratic corruption variable. The intuition seems, however, important, in suggesting that privatization may be a function of corruption in some countries. The policy implication is that international financial institutions should be aware that in some circumstances privatization may occur for the wrong reasons in LDCs.