jimnoneill/paper-to-field-training huggingface dataset:
Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Genetic linkage analyses in human populations have traditionally combined male and female progeny for determination of quantitative trait loci (QTL). In contrast, most rodent studies have focused primarily on males. This study represents an extensive female-specific linkage analysis in which 236 neuroendocrine, renal, and cardiovascular traits related to arterial pressure (BP) were determined in 99 female F2 rats derived from a cross of Dahl salt-sensitive SS/JrHsdMcwi (SS) and Brown Norway normotensive BN/SsNHsdMcwi (BN) rats. We identified 126 QTL for 96 traits on 19 of the 20 autosomal chromosomes of the female progeny. Four chromosomes (3, 6, 7, and 11) were identified as especially important in regulation of arterial pressure and renal function, since aggregates of 8–11 QTL mapped together on these chromosomes. BP QTL in this female population differed considerably from those previously found in male, other female, or mixed sex population linkage analysis studies using SS rats. Kidney weight divided by body weight was identified as an intermediate phenotype that mapped to the same region of the genome as resting diastolic blood pressure and was correlated with that same BP phenotype. Seven other phenotypes were considered as “potential intermediate phenotypes, ” which mapped to the same region of the genome as a BP QTL but were not correlated with BP. These included renal vascular responses to ANG II and ACh and indices of baroreceptor responsiveness. Secondary traits were also identified that were likely to be consequences of hypertension (correlated with BP but not mapped to a BP QTL). Seven such traits were found, notably heart rate, plasma cholesterol, and renal glomerular injury. The development of a female rat systems biology map of cardiovascular function represents the first attempt to prioritize those regions of the genome important for development of hypertension and end organ damage in female rats.
Safety and efficacy of inpatient pulmonary rehabilitation for patients hospitalised with an acute exacerbation of chronic obstructive pulmonary disease: a systematic review protocol

Field: Health Professions (Health Sciences)

Introduction Pulmonary rehabilitation (PR) following an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) reduces the risk of hospital admissions, and improves physical function and health-related quality of life. However, the safety and efficacy of in-hospital PR during the most acute phase of an AECOPD is not well established. This paper describes the protocol for a systematic review with meta-analysis to determine the safety and efficacy of inpatient acute care PR during the hospitalisation phase. Methods and analysis Medical literature databases and registries MEDLINE, EMBASE, Physiotherapy Evidence Database, Cumulative Index to Nursing and Allied Health Literature, Canadian Agency for Drugs and Technologies in Health, CENTRAL, Allied and Complementary Medicine Database, WHO trials portal and ClinicalTrials.gov will be searched for articles from inception to June 2021 using a prespecified search strategy. We will identify randomised controlled trials that have a comparison of in-hospital PR with usual care. PR programmes had to commence during the hospitalisation and include a minimum of two sessions. Title and abstract followed by full-text screening will be conducted independently by two reviewers. A meta-analysis will be performed if there is sufficient homogeneity across selected studies or groups of studies. The Population, Intervention, Comparator, Outcomes and Study characteristics framework will be used to standardise the data collection process. The quality of the cumulative evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations framework. Ethics and dissemination AECOPD results in physical limitations which are amenable to PR. This review will assess the safety and efficacy of in-hospital PR for AECOPD. The results will be presented in a peer-reviewed publication and at research conferences. Ethical review is not required for this study. PROSPERO registration number CRD42021198877.
Double stapled transabdominal anastomosis for one-stage resection of acute sigmoid volvulus

Field: Medicine (Health Sciences)

Reduced long-term survival following major peptic ulcer haemorrhage SirThis study (Br J Surg 1997; 84: 265-8) draws attention to the consequences (non-fatal and fatal peptic ulcer recurrence) of allowing the preoccupation with surgical procedures that alleviate life-threatening complications to dominate clinical decision-making, to the exclusion of strategies (medical or surgical) that modify favourably the natural history of peptic ulcer disease.The recognition that the peptic ulcer diathesis is one characterized by a relapsing course, even in the modern therapeutic era', mandates the implementation of strategies to reduce the recurrence rate, regardless of the immediate success of measures such as endoscopic haemostatic therapy.The prophylactic range includes, respectively, eradication of Helicobacter pylori in patients with proven infection2 and longterm use of antisecretory therapy in those who are H. pylorinegative'.A case could even be made for a 'belt and braces' strategy, using both treatments, in high-risk subgroups such as the elderly and those with serious co-morbidity.Even after successful eradication of H. pylori 4-6 per cent of peptic ulcers recur4 and sometimes with haemorrhagic sequelae2.For those with co-morbid disorders necessitating co-prescription of nonsteroidal anti-inflammatory drugs (NSAIDs), misoprostol is preferable to H2-receptor antagonists as it protects the duodenum (the only site protected by ranitidine)' and the stomach', the site most favoured by NSAID-related ulcers".For those intolerant of the optimum recommended dose of 200pg four times daily, modest prophylactic benefit, with significantly fewer side-effects, can still be obtained with a 50 per cent dose reduction'.
Investigating the nephrotoxic effects of medroxyprogesterone in female albino rats

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Progestins, though integral to various bodily functions as endogenous hormones, have been associated with adverse effects when administered exogenously in excessive amounts. This study investigates the impact of medroxyprogesterone (MePro) on kidney function, examining biochemical parameters, histology, and oxidative stress markers. Methods. Twenty healthy adult female Albino rats were assigned to four groups: Group 1 consisted of 10 rats before MePro treatment, Group 2 comprised the same rats 8 weeks after intramuscular MePro administration (3.5 mg/week), Group 3 served as the control group, and Group 4 represented the same rats as Group 3 at the conclusion of the study. Serological and histological markers of renal damage, as well as parameters of oxidative stress (malondialdehyde, MDA) and antioxidant status (total antioxidant status, TAS), were investigated in female albino rats following MePro administration. Results. MePro administration resulted in notable increases in weight, urea, creatinine, and MDA levels, alongside a decrease in TAS compared to baseline levels (p < 0.001). Conversely, the control groups showed no significant changes in these parameters over time. Creatinine levels and oxidative stress markers in Group 2 were notably higher than those in Groups 3 and 4 (p < 0.001). Post-MePro administration, renal histopathology revealed significant deposition of hyaline casts in the tubular lumens, along with vascular lesions, hemorrhage, and inflammation. Conclusions. The decline in kidney function, antioxidant status, and propensity for renal injury associated with MePro use underscore its potential renal toxicity.
Oesophageal achalasia mistaken for anorexia nervosa.

Field: Medicine (Health Sciences)

their general practitioner.Taking into considera- tion the points already made about possible reasons for their visit to the department and the general nature of the question asked, the figure does not seem to differ from that found in other studies.2The study asked a vague general question about consultations with a general practitioner before the visit to the accident and emergency department and consequently got vague general data, from which no conclusions can be drawn.Perhaps more disturbing is the implied criticism of general practitioners' diagnostic ability.I hope that I am being hypersensitive after my second 120 hour week this month and that no such criticism was meant.
Assessment of Occupational Exposure to External Radiation among Workers at the Institute of Radiotherapy and Nuclear Medicine, Pakistan (2009-2016)

Field: Health Professions (Health Sciences)

Introduction: Assessment of occupational exposure to external radiation and the analysis of associated trends are imperative to observe changes that have taken place over time due to regulatory operations or technological advancements. Herein, we describe the occupational radiation exposure to workers employed in Nuclear Medicine (NM), Radiotherapy (RT), and Diagnostic Radiology (DR) departments at the Institute of Radiotherapy and Nuclear Medicine, Peshawar, Pakistan, and to evaluate the related trends during 2009-2016. Materials and Methods: A retrospective analysis of the dose records of 4320 film dosimeters was performed during 2009-2016. The analyzed quantities included annual collective effective dose, annual average effective dose, distribution of workers, and their annual average effective doses in various effective dose intervals, as well as the maximum and minimum annual individual effective doses. Results: The annual average effective doses in RT, NM, and DR were within the ranges of 1.07-1.45, 1.25-1.55, and 1.03-1.60 mSv, respectively. The majority (90%) of the workers received effective doses in the interval of 1-4.99 mSv, while 10% of the workers received doses within the range of the minimum detectable level-0.99 mSv. The minimum and maximum annual individual effective doses were 0.30 mSv and 3.96 mSv as recorded in RT and NM, respectively. The annual average effective doses measured for NM, RT, and DR were 1.39, 1.23, and 1.30 mSv, respectively. These values are comparable with the worldwide annual average effective doses. Conclusion: All the workers received doses below the annual dose limit. The status and trends of doses showed that radiation protection conditions were adequate.
Pengaruh Keragaman Produk Terhadap Keputusan Pembelian Pada Vierra Oleh-Oleh Kota Pekanbaru

Field: Business, Management and Accounting (Social Sciences)

The purpose of this study was to analyze, know and explain the effect of product diversity on purchasing decisions at Viera Souvenirs in Pekanbaru City. This research uses quantitative methods by processing the data obtained from the population and research sample of 100 respondents. The type and source of data used in this research is using secondary data and primary data where data collection is through distributing questionnaires and conducting interviews. Then from the data that has been collected the authors identify and classify the data using descriptive analysis methods, namely conducting research from data that has been found in the field. From the results of the study, it was obtained that the product diversity variable was in the strongly agree category, and the purchase decision variable was in the strongly agree category. Then from statistical calculations there are results where product diversity has a significant effect on purchasing decisions at Viera Souvenirs in Pek anbaru City.
Failure of Alkaline Methods to Measure Degree of Polymerization of Carbohydrates. Comparison with Chlorite Method

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFailure of Alkaline Methods to Measure Degree of Polymerization of Carbohydrates. Comparison with Chlorite MethodH. F. Launer and Yoshio. TomimatsuCite this: Anal. Chem. 1961, 33, 1, 79–83Publication Date (Print):January 1, 1961Publication History Published online1 May 2002Published inissue 1 January 1961https://pubs.acs.org/doi/10.1021/ac60169a023https://doi.org/10.1021/ac60169a023research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Commonly Used Types and Recent Development of Ankle-Foot Orthosis: A Narrative Review

Field: Health Professions (Health Sciences)

(1) Background: ankle-foot orthosis (AFO) is the most commonly prescribed orthosis to patients with foot drop, and ankle and foot problems. In this study, we aimed to review the commonly used types of AFO and introduce the recent development of AFO. (2) Methods: narrative review. (3) Results: AFO prevents the foot from being dragged, provides a clearance between the foot and the ground in the swinging phase of gait, and maintains a stable posture by allowing heel contact with the ground during the stance phase. In clinical practice, the most commonly used AFO include plastic AFO, walking boot, UD-Flex, and carbon fiber AFO. In addition, for compensating the demerits of these conventional AFOs, new types of AFOs, including AF Servo, TurboMed, three-dimensionally printed AFO, and AFO made from kenaf composites, were developed. (4) Conclusions: we think that our review can guide clinicians in selecting and prescribing the appropriate AFO for each patient in accordance with their specific physical conditions.
Transfusion Policy After Severe Postpartum Hemorrhage

Field: Medicine (Health Sciences)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious Issues Collections Obstetric Airway ManagementMaternal EmbolismRegional Anesthesia for Cesarean SectionGeneral Anesthesia for Cesarean SectionAnalgesia for LaborObstetric HemorrhagePre-Eclampsia/EclampsiaPharmacologyTraumaInfection and SepsisMaternal ObesityMaternl Morbidity and MortalityNeonatal Morbidity and MortalityObstetric ComplicationsAnesthetic ComplicationsNon-Obstetric Maternal DiseaseCritical CareDrug Abuse in PregnancyEthicsSystems Based Practice For Authors Information for AuthorsLanguage Editing Services Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
Parasitism and pathogenicity of curly-leaf parsley with the root-knot nematode Meloidogyne javanica in Southern Italy

Field: Agricultural and Biological Sciences (Life Sciences)

Summary Severe infections of parsley plants and soil infestations with Meloidogyne javanica during an autumn surveys for the pathogenic root-knot nematode infestations were found in Monopoli at Bari province in Southern Italy. This unusual severe infection of parsley, considered a winter crop, was possibly instigated by a very warm autumn from the previous year. Nematodes were extracted from soil samples according to the Coolen’s method. Morphological analysis (based on stylet length, tail length and shape, adult females perineal pattern, excretory pore position and Ep/stylet ratio) and molecular studies were used for the nematode characterization and identification. In the soil of infested area a severely deformed root systems were observed, showing a galling rate = 2.5 - 4 (scale 0-5) and a soil nematode population densities ranging from 350 to 2,730 eggs and J2 per 5 g of fresh root. M. javanica attack on parsley roots is a limiting factor for plant growth. Considering that curly-leaf parsley varieties resistant to the nematodes are not yet available control strategies must be focused on reduction of soil infestation level below tolerance limit of the target nematode species. Due to the higher cost and reduced availability of fumigant and non-fumigant nematicides, soil solarization, organic amendments or biological control approaches should be preferably used as alternatives.
Researching Psychiatry in Western Australia

Field: Neuroscience (Life Sciences)

Objective: To provide an overview of the development, approaches and main research projects of the Centre for Clinical Research in Neuropsychiatry (CCRN) in Perth, Western Australia. Method: Discursive. Results: Underlying concepts, methods and selected findings of recent research into the neurobiology and epidemiology of schizophrenia, autism and other psychotic disorders are presented. Conclusion: CCRN, one of Australia's youngest centres of psychiatric research, has invested fruitfully in research areas such as molecular genetics, neuropsychology, neurophysiology, behavioural pharmacology, diagnostic assessment procedures and record linkage epidemiology.
Electrochemical Testing of Modular Taper Junctions: Effect of Assembly Force and Head Offset

Field: Engineering (Physical Sciences)

Examinations of retrieved orthopedic implants have demonstrated corrosion; however, the extent of corrosion damage can be quite variable. There are a number of factors that may influence this corrosion, including device design and materials, surgical technique, and patient factors such as lifestyle, activity, and comorbidities that affect the local physiological environment around the hip prosthesis. This study evaluated the effect of a number of those factors on the corrosion of the head-stem junction of a modular hip using an electrochemical method. Several groups of head-stem taper coupons were immersed in phosphate-buffered saline and held at a constant anodic potential in an electrochemical cell while being mechanically loaded. Femoral head size, diameter, offset, and assembly force were varied. Incrementally increasing cyclic loads were applied to the femoral head. After the short-term incremental test was completed, some specimens were subjected to a long-term 4-kN cyclic load (R = 0.1) that was applied for 106 cycles. Current was continually monitored, and displacement sensors monitored the relative micromotion of the assembled components. Test specimens assembled with less than 4 kN of load experienced a statistically significant increase in corrosion current during both the short-term and long-term tests compared to specimens assembled with higher loads. The larger +12-mm head offset exhibited a statistically significant increase in corrosion current compared to the +8.5-mm offset in the long-term test when assembled with the 1-kN load. It is recommended that taper assembly force and head offset should be controlled in future corrosion tests of taper junctions. Although there are measurable differences in corrosion current reported in this laboratory experiment, the values for corrosion current have not been correlated with clinical performance or outcomes. This study has shown that assembly technique and head offset are factors that affect corrosion current measured in the laboratory.
Dorsal Modification: Practical Applications in Rhinoplasty

Field: Medicine (Health Sciences)

Abstract Background Management of the dorsum continues to present challenges for rhinoplasty surgeons, especially regarding the inherent asymmetry of the bony and cartilaginous vaults and the need for a highly individualized approach for each case. Objectives The aim of this study was to assess the efficiency of superficial dorsal modification to improve the shape and symmetry of the dorsum, without resecting/reconstructing the main parts that maintain dorsal stability. Methods A total of 147 patients who underwent superficial dorsal modification between October 2020 and March 2024 were retrospectively reviewed. A step-by-step algorithm was applied to achieve the required dorsal improvement. Results The average postoperative follow-up period was 27 months (range, 12-41 months). No patients required revision surgery of their dorsum. No complications were reported. A retrospective analysis of the 147 patients demonstrated aesthetic and functional improvement. Conclusions Dorsal modification as a separate philosophy is a very conservative, fast, and reliable approach. In cases where there is no need to significantly change dorsal dimensions (height and width), dorsal modification improves the dorsum quickly and efficiently without significant resection and no reconstruction, while maintaining stability and maximum predictability.
Spectroscopic and Biological Studies on Newly Synthesized Cobalt (II) and Nickel (II) Complexes with 2-Acetyl Coumarone Semicarbazone and 2-Acetyl Coumarone Thiosemicarbazone

Field: Chemistry (Physical Sciences)

Co(II) and Ni(II) complexes of general composition ML 2 X 2 (M = Co(II), Ni(II); X = Cl − ,NO3 −) were synthesized by the condensation of metal salts with semicarbazone/thiosemicarbazone derived from 2-acetyl coumarone. The ligands and metal complexes were characterized by NMR, elemental analysis, molar conductance, magnetic susceptibility measurements, IR, and atomic absorption spectral studies. On the basis of electronic, molar conductance and infrared spectral studies, the complexes were found to have square planar geometry. The Schiff bases and their metal complexes were tested for their antibacterial and antioxidant activities.
3D Computational Modeling and Simulation of Cell Motion on Adhesive Surfaces in Shear Flow

Field: Computer Science (Physical Sciences)

A three-dimensional computational fluid dynamic (CFD) model is presented to simulate transient rolling adhesion and deformation of leukocytes over a P-selectin coated surface in shear flow. The computational model is based on immersed boundary method for cell deformation, and stochastic Monte Carlo simulation for receptor/ligand interaction. The model is shown to predict the characteristic ‘stop-and-go’ motion of rolling leukocytes. The objective here is to understand the coupling between external shear flow, cell deformation, microvilli deformation and various biophysical parameters that govern the formation of selectin bonds. We observe that compliant cells roll more stably with lesser fluctuations. Adhesion is seen to occur via multiple tethers, but often one tether is sufficient to support rolling. The force loading on individual microvillus is not continuous, rather occurs in steps. Further, it is also shown that only the microvilli whose undeformed length is above a certain cut off length, participate in bond formation and the cutoff length reduces with increasing cell rigidity.