jimnoneill/paper-to-field-training huggingface dataset:
MESENDODERMAL PROGENITORS IN COMBINATION WITH A SYNTHETIC HYDROGEL (NPGEL) IN A SHEEP MODEL OF LOW BACK PAIN: A SAFETY STUDY

Field: Medicine (Health Sciences)

Introduction Low back pain (LBP) is a worldwide leading cause of disability. This preclinical study evaluated the safety of a combined advanced therapy medicinal product developed during the European iPSpine project (#825925) consisting of mesendoderm progenitor cells (MEPC), derived from human induced pluripotent stem cells, in combination with a synthetic poly(N-isopropylacrylamide) hydrogel (NPgel) in an ovine intervertebral disc degeneration (IDD) model. Method IDD was induced through nucleotomy in 4 adult sheep, 5 lumbar discs each (n=20). After 5 weeks, 3 alternating discs were treated with NPgel (n=6) or NPgel+MEPC (n=6). Before sacrifice, animals were subjected to: MRI of lumbar spines (disc height and Pfirmann grading); blood sampling (hematological, biochemical, metabolic and lymphocyte/monocytes immunological). After 3 months the sheep were sacrificed. The spines were processed for: macroscopic morphology (Thompson grading), microscopic morphology (Histological grading), and glycosaminoglycan content (GAG, DMMB Assay). Furthermore, at sacrifice biodistribution of human MEPC was assessed by Alu-sequences quantification (qPCR) from three tissue samples of heart, liver, spleen, brain, lungs, and kidneys, and PBMCs collected to assess activation of systemic immune cells. To each evaluation, appropriate statistical analysis was applied. Result Flow cytometry showed no induction of systemic activation of T cells or monocytes. Alu quantification did not give detection of any cells in any organ. Disc height index was slightly increased in discs treated with NPgel+MEPC. Pfirmann's and Thompson's classification showed that treatment with NPgel or NPgel+MEPC gave no adverse reactions. Histological grading showed similar degeneration in vertebrae treated with NPgel+MEPC or with NPgel alone. The amount of GAG was significantly increased in the nucleus pulposus following treatment with NPgel+MEPC compared to NPgel alone, in which a decrease was observed compared to untreated discs in both nucleus pulposus and annulus fibrosus. Conclusion This study showed the safety of both NPgel+MEPC and NPgel treatments.
Application of Biomedical Sensor and Transducer in the Elderly

Field: Health Professions (Health Sciences)

In the elderly society, the sensor and transducers are applied to improve quality of life. Sensors are attached to the furniture or inside a room instead of attached to the human.The non-invasive and unconstrained monitoring are performed in the home and less constrained monitoring using portable-small sensor are used. In this paper, recent development of sensor and transducer in the Gerontechnology field is reviewed.
Screening for hypothyroidism: an avenue for research

Field: Medicine (Health Sciences)

Screening for hypothyroidism has been a regular feature of routine diabetes screening in outpatient clinics. In present times of financial constraints and in an environment where all blood tests and investigations are coming under scrutiny, the article by Whitehead et al. raises some pertinent questions. This study suggests that annual screening for hypothyroidism requiring thyroxine treatment (HRTT) in a hospital-based diabetes clinic is unlikely to be cost effective. The problem is that, though this highlights a lack of benefit from a financial point of view, it does not give us a viable alternative. Focused screening such as that used in glucose tolerance tests for pregnant women with diabetes may be an option, but Whitehead et al. point out that targeted screening based on age and gender appears, in this study, to be no better than simply randomly reducing the number of tests done. Options to consider could be screening patients with symptoms of hypothyroidism, hyperlipidaemia or positive thyroid auto-antibodies, screening new patients and screening every two years which may be of merit, but there is a lack of evidence base to support any of these approaches at the moment. One option may be to screen for thyroid antibodies and, if positive, then recheck thyroid function on an annual basis to pick up any hypo-thyroidism requiring treatment – however, once again, there need to be further studies looking at the sensitivity and specificity of this approach. Nevertheless, this study does raise valid questions and opens up an avenue of research. The financial model would be interesting when replicated in a local setting – i.e. in the UK. Diabetes departmental budget holders would surely be keen to consider an approach which would not compromise patient care but which would, at the same time, address the issue of keeping costs down.
Application of two stage rate limit control for different operating modes of battery

Field: Energy (Physical Sciences)

The present work deals with the application of two stage rate limit control for battery energy storage system under different operating modes. Energy storage systems are playing very important role in renewable power systems and microgrids. Depending on the nature of power requirement, utilization of multiple energy storage units with distinguished characteristics in terms of power and energy density is quite common in microgrids. Batteries are one of the most commonly used energy storage systems in microgrids, to support slow transients or steady state load demands. The power charge/discharge rates affects the stress levels in the battery, which in turn affects the battery life span; and its power pattern affects stored/discharge energy from the battery, which in turn affects the state of charge (SOC) of the battery. Therefore, to optimize the charge/discharge rates a two stage rate limit control scheme is proposed, and its application for different operating modes is discussed in this paper. This control scheme is verified in OPAL-RT by creating real-time control hardware in loop (CHIL) with dSPACE.
Risk of cerebral haemorrhage in patients treated with antithrombotic drugs. Focus on new oral anticoaguants

Field: Medicine (Health Sciences)

Antithrombotic drugs represent one of the leading pharmacological category used in clinical practice, especially in cardiovascular setting. Their demonstrated antithrombotic efficacy has been fundamental in the improvement of the management of many diseases related to athero-thrombotic or thromboembolic risk in prevention and treatment of cardiovascular events. Nonetheless, they are also associated with a not negligible haemorrhagic risk. Among these risks, intracranial bleeding represents the most feared, and should be kept in mind, prevented when possible and adequately managed when occurs. In this article the intracranial haemorrhagic risk associated to drugs vitamin K antagonists and new oral anticoagulants is reviewed.
Advanced pedagogical practices using active teaching methodologies in Technical Drawing in Engineering

Field: Social Sciences (Social Sciences)

The main theme of this article is the application of new technological tools and the deepening of content and knowledge in the Basic Drawing discipline of the Production Engineering course at UFF in Rio das Ostras. The work was conducted by the coordinator with the support of a monitor and the exploration of Active Learning Methodologies, with the objective of developing the student's protagonism in the construction of knowledge. Teamwork and the sharing of ideas were encouraged, which contributed to a dynamic and collaborative learning environment, including the use of AUTOCAD for the preparation of drawings and participation in seminars. The results were positive, since it aroused greater interest among students and brought them closer to the reality of the job market.
Seismic Retrofit of Steel Deck-Truss Bridges: Experimental Investigation

Field: Engineering (Physical Sciences)

Alternative seismic retrofit strategies for steel deck-truss bridges are investigated in this study. Various modified tension-only bracing configurations, which consist of tendon elements with or without supplemental systems are introduced within the end-sway frames. The effectiveness of the retrofit configurations is demonstrated experimentally and analytically on a one-third scale model of an existing steel end-sway frame tested on the shaking table at the State University of New York at Buffalo. It is concluded that proposed alternatives can efficiently improve the lateral strength and stiffness characteristics. Moreover, the load path within the end-sway frame is modified to bypass the existing nonductile steel bearings. A stable energy dissipation mechanism is provided by means of re-centering elastomeric spring dampers along with fuse elements, thus reducing the overall seismic demand on the structural systems.
Multi-class & binary classification of Parkinson’s disease and SWEDD variants using SBR features derived from SPECT imaging

Field: Medicine (Health Sciences)

Parkinson's disease (PD) becomes the second most common disease and is caused by the loss of dopamine neurons. It is very challenging to detect the disease at an early stage and the chances of misdiagnosis are high due to the similarity of symptoms to other disorders. Therefore, this paper proposed a deep learning-based automatic deep neural network (DNN) model for diagnosing disease as early as possible. The binary and multiclass classifications have been done among three classes (PD, SWEDD, and Healthy people) by using SBR features of SPECT modality. Even also compared the results of the proposed model of both classification categories with other highly used machine learning algorithms (Support vector machines, Naive Bayes, k-nearest neighbors, and decision trees) in literature. From the outcomes, it has been observed that the proposed DNN model provided the highest accuracy in comparison with other classifiers i.e. 97.67%, 83.43%, 94.46%, & 83.18% for PD vs Healthy, SWEDD vs Healthy, PD vs SWEDD, and PD vs SWEDD vs healthy classification probabilities respectively. Hence, this automatic DNN classifier may aid professionals to diagnose the disease in an early stage.
Development of a multi-objective scheduling system for offshore projects based on hybrid non-dominated sorting genetic algorithm

Field: Decision Sciences (Social Sciences)

In order to enhance the efficiency of offshore companies, a multi-objective scheduling system based on hybrid non-dominated sorting genetic algorithm was proposed. An optimized model for multi-objective and multi-execution mode was constructed under the condition of taking time, cost, and resource into account, and then the mathematical model for the same was established. Moreover, the key techniques of the proposed system were elaborated, and the flowchart was designed. Aiming at the weaknesses of non-dominated sorting genetic algorithm which is short for non-dominated sorting genetic algorithm-II in the facet of local search and computational efficiency, Pareto-dominated simulated annealing algorithm was applied in search global solution. Finally, by simulation examples and industrial application, the robustness and outperformance of the improved algorithm were verified.
REGIONAL DEVELOPMENT OF THE REPUBLIC OF SERBIA IN THE LIGHT OF KEY MESSAGES OF ENDOGENOUS THEORY OF GROWTH AND IMPERATIVES FOR IMPROVING COMPETITIVENESS

Field: Economics, Econometrics and Finance (Social Sciences)

At the end of the twentieth century, a qualitatively new concept of regional development policies appeared, and was affirmed, in many world economies. In short, at its center, there is the imperative to improve the region's competitiveness. The focus of new regional development policies is on initiatives that favor networking, the development of cooperative relationships, and the growth of confidence in regional economic actors. In these circumstances, people's readiness for new business ideas and organizational solutions have become far more important drivers of regional development than the number of businesses located in the region. The new concept of regional development policy is predominantly based on the postulates of endogenous growth theory. The imperative to improve the region's competitiveness is at its epicenter. Starting from such prominent theoretical explanations, our own composite index was constructed by analyzing the achieved level of development of individual regions of the Republic of Serbia in 2008 and 2018. The analysis showed that all regions in Serbia have development potentials, but that they manage to increase their level of development to a different extent, both in relation to the previous period and in relation to other regions in the country.
Pseudomonas avenae Causing Bacterial Brown Stripe Disease of Rice in Korea

Field: Agricultural and Biological Sciences (Life Sciences)

A bacterial brown stripe disease new to Korea was noted for the first time on rice seedlings grown in the nursery pots and in a field nursery. Artificial hypodermic injection and pricking inoculation with isolates obtained from lesions of naturally infected plants produced symptoms similar to those occurring under natural condition. Among eleven species of ten genera of gramineous plants Echinochloa crusgalli, Digitaria sanguinalis and Setaria viridis were the new hosts for the pathogen. On the basis of bacteriological and biochemical tests of isolates from infected rice seedlings, the causal bacterium is considered to be Pseudomonas avenae Manns.
The Dynamic Correlation between ASEAN-5 Stock Markets and World Oil Prices

Field: Economics, Econometrics and Finance (Social Sciences)

Various studies on the relationship between world oil prices and stock markets that have been done previously mostly still done by using a static approach or an approach to test whether there is a short-term or long-term relationship. This research scrutinizes the dynamic relationship between world oil price change with the return of ASEAN’s main stock markets such as Indonesia, Singapore, Malaysia, the Philippines, and Thailand by using Dynamic Conditional Correlation-Generalized Autoregressive Conditional Heteroscedasticity (DCC-GARCH). The result shows that the correlation between world oil price’s change with the return of ASEAN’s main stock market was not static but change according to the stock market and the commodity market’s condition. During the normal period, DCC-GARCH is in the narrow range and stable, but during the period of stock market and commodity market turbulence, DCC-GARCH could alter extremely from positive to negative in some ASEAN countries. Generally, it is concluded that the use of a static approach was not appropriate especially for rapidly changing in the financial market and commodity market. JEL Classification: G10; G15; Q41
Influence of Fly Ash and Palm Fibre on the Mechanical Properties of Compressed Stabilized Earth Blocks

Field: Engineering (Physical Sciences)

The global population growth and escalating cost of building materials have resulted in a global housing deficit. There has also been a growing concern about environmental and ecological issues caused by human activities. This has prompted continuous research efforts into the beneficial use of these wastes in developing sustainable, affordable and eco-friendly building materials. This research evaluated the effect of fly ash and palm fibre on the density and compressive strength of compressed stabilized earth blocks. Fly ash was used to stabilize lateritic soil at 0%, 2.5%, 5%, 7.5% and 10% while palm fibre was used to reinforce the lateritic soil at a constant proportion of 1% by weight of laterite. The blocks were cured for 28 days after which they were tested. The results obtained indicate that the addition of fly ash in the matrix increased the density and compressive strength of the blocks. The blocks produced with fly ash in the matrix meet the minimum compressive strength requirements for lateritic blocks as specified by the Nigeria Building and Road Research Institute. An optimum stabilization and reinforcement of lateritic soil with 7.5% fly ash and 1% palm fibre by weight respectively of lateritic soil is recommended.
Four-Stage Degradation Physics of Rolling Element Bearings

Field: Engineering (Physical Sciences)

Rolling element bearings are a critical component of rotating machinery. Timely prediction of bearing faults become of great importance to minimizing unscheduled machine downtime. Most of the bearings experience gradual condition degradation due to repeated mechanical loads.Vibration signals are often used for bearing diagnosis and prognosis with a predefined threshold. However, false (positive/negative) alarms are often observed, thus leading to unnecessary downtime and expensive corrective maintenance. This is mainly because the thresholds are defined without accounting for bearing physics and a great deal of uncertainty in manufacturing and operation condition. To resolve this difficulty, this study aims at investigating the degradation physics of rolling element bearings using a vibration signal, while accounting for bearing physics and a substantial amount of uncertainty in manufacturing and operation condition. First, bearing feature engineering is thoroughly studied through timedomain and frequency domain analyses. This study proposes the features that are most sensitive to the change in bearing physics. Second, bearing degradation physics is investigated so that the bearing degradation process can be modeled into four degradation stages. To the end, theproposed idea is demonstrated with vibration data measured from rolling element bearings, which experience accelerated life tested to simulate naturally induced degradation. This study will benefit to enhance physical understanding for bearing faults in various engineering applications.
Irreversible enzyme inhibitors. CXV. Proteolytic enzymes. 5. Active-site-directed irreversible inhibitors of trypsin derived from p-(phenoxyalkoxy)benzamidines with a terminal sulfonyl fluoride

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIrreversible enzyme inhibitors. CXV. Proteolytic enzymes. 5. Active-site-directed irreversible inhibitors of trypsin derived from p-(phenoxyalkoxy)benzamidines with a terminal sulfonyl fluorideBernard Randall Baker and Edward H. EricksonCite this: J. Med. Chem. 1968, 11, 2, 245–249Publication Date (Print):March 1, 1968Publication History Published online1 May 2002Published inissue 1 March 1968https://doi.org/10.1021/jm00308a011RIGHTS & PERMISSIONSArticle Views77Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (648 KB) Get e-Alerts Get e-Alerts
Volume 77, no. 1, 2003, Table of Contents and Author Index and Volume Author Index

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Table of Contents and Author Index: “Michael Laughrea” should be added to the list of authors for the article “Sequences Downstream of the 5′ Splice Donor Site Are Required for both Packaging and Dimerization of Human Immunodeficiency Virus Type 1 RNA,” p. 84-96.
Some Considerations Regarding the 1H and 13C Spectra of 4-(1-azulenyl)-2,6-bis(2-heteroaryl-vinyl)- pyrylium and Pyridinium and their Corresponding Pyridines

Field: Chemistry (Physical Sciences)

The 1H and 13C NMR spectra of several 2,6-diheteroarylvinyl heterocycles containing 4-azulenyl moiety were recorded and their proton and carbon chemical shifts were compared with those of the compounds without double bond between the heterocycles. The influence of the nature of central and side heterocycles, molecule polarization and anisotropic effects were revealed. The highest chemical shifts were recorded for the pyrylium salts and the lowest at pyridines, but in the case of the pyridinium salts, the protons chemical shifts at the central heterocycle are more shielded due to a peculiar anisotropy of the attached vinyl groups.
The New Zimbabwean Government’s War on Corruption: A Lesson for Anti-Corruption and Transitional Justice Scholars and Practitioners?

Field: Social Sciences (Social Sciences)

There is ample academic writing and practical examples extending the principles of transitional justice to corruption. However, very little has been written on how a society’s existing anti-corruption mechanisms may be utilised in a manner compatible with the wider transitional justice processes. In Zimbabwe, the new government is taking a more rigorous approach towards anti-corruption than towards the protection of human rights, which is apparent in its pursuing corruption crimes but not crimes which violate physical integrity, such as torture, disappearances and killings. Using Zimbabwe as an example, this paper proposes ways in which transitional authorities could rely on anti-corruption mechanisms, yet go beyond them by addressing endemic corruption under the broader transitional justice mechanisms. This synchronisation will ensure that corruption is not addressed in a silo but as part of a wider redress of gross human rights violations. Such an articulation is all the more important given that societies perceived to be highly corrupt also tend to be those with poor human rights records. Moreover, the new government has acknowledged the endemic nature of corruption and has relied on the need to address it to justify the military intervention — a ground that resonated across society and appeared to legitimise the intervention. If, therefore, the new government’s anti-corruption campaign is to be trusted to end impunity with respect to physical abuses, it has to be consistent with, and grounded in, relevant domestic and international law.