jimnoneill/paper-to-field-training huggingface dataset:
Supplementary Figures S1-S3 and Suppl. Tables S1-S2 from AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor–Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>Supplemental tables S1-S2: (S1) sequences of sgRNA for CRISPR-cas9 knock out cell lines. (S2) Fraction of oxygen consumption rate remaining after tamoxifen treatment at 30μM in cancer cell lines Supplemental Figures S1-S3: (S1) Oxygen consumption measurements of Tamoxifen, 4OH-Tamoxifen, and fulvestrant treatment, oxygen consumption of MCF7 cells treated with DMSO or fulvestrant plus tamoxifen and Immunoblot of ER expression with fulvestrant treatment, oxygen consumption measurements of mitochondria isolated from mouse liver treated with tamoxifen, clonogenic survival of MDA-231 cells treated with tamoxifen +/- Glucose and +/- methyl succinate, immunoblot of AMPK activation in the presence of glucose or 2DG and survival of BC cells treated with 2DG or 3BP. (S2) LC-MS/MS quantification of acyl-CoA species after tamoxifen treatment compared to control and BODPIY staining of MDA-231 cells treated with tamoxifen or DMSO control. (S3) Clonogenic survival and immunoblot of MCF7 shNT and shAMPK cells treated with 30μM tamoxifen, survival assays of MDA-231 cells with different AMPK status's following tamoxifen treatment, and autoradiograph film of 35S labeling in MDA-231 cells and MDA-231 crspAMPKα1.</p>
6409 Safety netting in a Children’s emergency department

Field: Health Professions (Health Sciences)

Objectives

Evaluate documentation of safety netting advice given to parents, carers, children and young people, in a children's emergency department at a district general hospital Standardise the provision of both written and verbal safety netting advice Incorporate safety netting training in medical inductions Develop a safety netting advice leaflet for the children's emergency department

Methods

Retrospective review of electronic discharge summaries from 22nd April to 27th May 2021 Stratified random sampling was used A total of 48 discharge summaries were reviewed 12 discharge summaries chosen from weekdays – daytime shifts 12 discharge summaries chosen from weekdays – evening/night shifts 12 discharge summaries chosen from weekends – daytime shifts 12 discharge summaries chosen from weekends – evening/night shifts

Results

29% of discharge summaries did not have any safety netting advice documented (14/48) 21% of discharge summaries had unspecific safety netting advice documented (10/48) 50% of discharge summaries had specific safety netting advice documented (24/48)

Conclusion

Only 50% of the reviewed discharge summaries had specific safety netting advice documented. Standards were not being met, as stipulated in Facing the Future RCPCH 2015 In this review we did not find sufficient evidence of good communication and documentation practices with regard to safety netting Although it cannot be assumed that the advice was not given verbally, when advice was documented, the level was very variable Recommendations were made and we created a safety netting advice leaflet with patient and public involvement. The leaflet was approved by the Trust Patient Information Review Panel and incorporated in the Trust intranet. Additionally safety netting training has now been incorporated in the induction program for Junior doctors at this Trust

References

Roland D, Jones C,Neill S, et al. Safety netting in healthcare settings: what it means, and for whom? Arch Dis Child Educ Pract Ed 2014;99:48–53. Facing the Future: Together for Child Health 2015 RCPCH. GMC 'Good medical practice', paragraph 32, (2013). https://mdujournal.themdu.com/issue-archive/issue-4/playing-it-safe---safety-netting-advice, 11/03/2016.
Taxes and Corporate Capital Structure in an Incomplete Market

Field: Economics, Econometrics and Finance (Social Sciences)

This paper extends Merton Miller's 1977 analysis of corporate capital structure decisions to the incomplete capital markets case. As in Miller's model, aggregate demand for corporate leverage is curtailed as interest rates on taxable bonds rise. Unlike Miller's model, however, capital structure is not a matter of indifference to all equilibrium shareholders. Market incompleteness and tax arbitrage restrictions combine to prevent marginal rates of substitution from being equalized for all investors and hence their preferences are not unanimous. In addition, costs associated with debt induce a tendency for lower cost firms to issue a larger proportion of total corporate debt.
Cure Analysis of Phenol-Formaldehyde Resins by Microdielectric Spectroscopy

Field: Chemical Engineering (Physical Sciences)

The influence of prepolymer functionality and pH conditions on the curing behavior of phenol-formaldehyde resins was studied by differential scanning calorimetry and microdielectric spectroscopy. Excellent agreement was found for these two analytical methods, readily distinguishing between the acid and alkaline cured systems. In terms of the rheology of the cure process, observed by changes in the resin conductivity, the greatest disparity was found between the two early stage resins when cured at acid pH. A much more rapid development of crosslinks and an apparently more extensive network structure observed for the earliest stage resin (PF-I) were attributed to the availability of more unsubstituted para positions on the aromatic ring for reaction with hydroxymethyl phenol groups. This effect was readily observable under both dynamic and isothermal curing regimes.
Headspace solid‐phase microextraction and gas chromatography–olfactometry analysis of raw spirits of different organoleptic quality

Field: Chemistry (Physical Sciences)

Abstract The aim of this research was to determine which compounds contribute to the flavour of agricultural distillates and to indicate those compounds which are responsible for a deterioration of sensory quality. Aroma profiling was carried out by headspace solid‐phase microextraction (HS‐SPME) and gas chromatography‐olfactometry (GC–O). Aroma profiles were obtained using the fingerspan method. It was ascertained that the aroma profiles of agricultural distillates contain about 40 odours, some of which may serve in discriminatory analysis as markers of sensory quality. Some of the aroma compounds could be identified with the use of a mass spectrometer. It was found that the greatest amount of information on quality was obtained through analysis of the most intense odours detected in all or almost all samples, and that two odours formed the most radical indicators of sensory quality, being the result of the presence of two compounds, dimethyl trisulphide and geosmin. Copyright © 2009 John Wiley & Sons, Ltd.
Formulasi strategi distributor alat dan mesin pertanian (studi kasus pt bina pertiwi)

Field: Business, Management and Accounting (Social Sciences)

Indonesia as an agrarian country faces the challenge of how to increase \nagricultural productivity to meet increasing needs. One way to increase agricultural \nproductivity is by mechanizing agriculture. For the passage of good mechanization \nof agriculture there is a need for adequate amounts of agricultural equipment and \nmachinery (alsintan). Thus, in Indonesia, alsintan is one of the businesses that still \nhas a large opportunity to develop. The existence of healthy agricultural machinery \ndistributor company is also expected to be one of the supporters of the success of \nagricultural mechanization in Indonesia. \nPT Bina Pertiwi (BP) is one of Indonesia's private companies which is a \nsubsidiary of PT United Tractors Tbk (UT). The company's main business is trading \nin agricultural machinery and equipment. Other business lines are forklifts, \ngenerator sets, construction machinery and the latest are heavy equipment \naftermarket parts. With a fairly diverse business line, this company is inseparable \nfrom the challenges of slow business growth as a result of external and internal \nchanges. In the period of 2014 to 2018 PT Bina Pertiwi experienced a stagnant value \nof sales growth and declining profits. \nThe objectives of this study are: 1) To analyze the strategic factors of the \nexternal and internal environment that affect the growth of the business of PT Bina \nPertiwi, 2) Formulate strategies that can be applied to increase the business growth \nof PT Bina Pertiwi, 3) Develop a strategies road map of PT Bina Pertiwi. \nThe method used consists of strategic factors analysis of the external \nenvironment with the framework of Politic, Economy, Social, Technology, \nEnvironment, Legal (PESTEL) and Porter’s 5 forces and internal factors with \nfunctional frameworks (marketing, sales, operations, finance, HR), External Factors \nEvaluation (EFE) analysis, Internal Factors Evaluation (IFE) analysis, Internal \nExternal (IE) matrix analysis, SWOT matrix analysis, and strategic architecture. \nThe results of the analysis show BP's external strategic factors include 6 \nopportunities and 6 threats. The internal strategic factors include 5 strengths and 4 \nweaknesses. In this study BP obtained EFE 2.617 and IFE 3.047. The position of \nBP in the IE matrix is quadrant IV which means grow & build with a choice of \nintensive and integrative strategies. \nThe results of the SWOT analysis provide BP with several strategies that can \nbe implemented, namely in the form of 7 SO strategies, 3 ST strategies, 5 WO \nstrategies. The choice of strategy is then compiled in a strategic architecture to \nbecome a road map for BP in the next 4 years towards the goals and objectives set \nby the company.
TENSIONS AMONG PORTUGUESES IN METACOMMENTARIES FROM EAST ASIAN INTERNATIONAL STUDENTS IN BRAZIL

Field: Social Sciences (Social Sciences)

ABSTRACT The aims of this paper are to analyse how East Asian international students narrate tensions in Portuguese language, or Portugueses, through metacommentary, and to foster reflections on the counter-hegemonic potential that language learning comprises, particularly when thinking of the internationalisation agenda implemented by a Brazilian public university. To pursue that, we depart from audio-recorded semi-structured interviews, later manually transcribed, with a Korean and a Japanese undergraduate student during their sojourn. We observed that these tensions in Portugueses arose as students’ communicative repertoires were put to the test, either by them or their interlocutors, in different spaces. Our discussion foregrounds how students, when engaging in various social practices on campus and off-campus, manoeuvre sociolinguistic scales in comments made by themselves or by their interlocutors about ways of speaking Portuguese. We considered that, overall, students resort to ecological factors when doing scales, whilst indexing dominant language ideologies. Moreover, it was also possible to conceive that metacommentary from their interlocutors, particularly from Brazilians, impact (negatively) on students’ perception about their language learning and linguistic practices. To tackle these tensions, we advocate for an internationalisation agenda that envisages language education not only to international students, but also to home students and staff in order to promote different degrees of language and social justice awareness.
Research on speed control for high-speed railway based on multi-mode intelligent control

Field: Engineering (Physical Sciences)

This paper puts forward to a new speed control method for the rapid development high-speed railway system. It receive information from track circuit, supervision speed curve, transponder and etc, deduce and calculate the speed value of dynamic expected, and calculate the real-time error. Then the closed-loop speed control system is used to realize the real-time control based on a multi-modal intelligent control algorithm that has been designed according to the real-time error. And make a simulation system to value it. The result shows it has good dynamic performance and reliable steady-state property. It is really a useful method to provide a advanced way for the train safer, faster and more comfort.
Managing double and multiple crises : examining crisis dynamics, organizational responses, and stakeholder activism

Field: Business, Management and Accounting (Social Sciences)

The black swan of crises – a double or multiple crisis event – may well cripple any organization despite it being crisis-ready. Using a multiple-case study method comprising six individual case studies of organizations and industries that had the misfortune of experiencing a second crisis before the first one is resolved, this study offers: A novel conceptualization of the double / multiple crisis; variations of the double / multiple crisis; and strategies rooted in Coombs’ (2012) Situational Crisis Communication Theory. This study found that for double and multiple crises, the original crisis does not affect organizational reputation the way crisis history does: Biernat’s (2012) assimilation-contrast theory may better explain how stakeholders attribute blame to companies experiencing the second crisis in a double crisis, or companies experiencing the latter crises in a multiple crisis situation. A contrast effect occurs when a double crisis situation comprises of two crises falling under different crisis clusters; in such instances, this study builds on SCCT recommendations to explore new frontiers of crisis management and communication response. This study extends Coombs’ Situational Crisis Communication Theory (2012) to account for a new variable: The double or multiple crisis. This study also offers the decision making framework for double crisis, to help practitioners choose appropriate SCCT strategies in a real-life double crisis, and the amount of resources to allocate to manage the crisis. Keywords: double crisis, multiple crisis, crisis history, crisis communication strategies
Immuno-Golgi method - Integrating immunohistochemistry and Golgi staining to characterize newborn neurons morphology

Field: Neuroscience (Life Sciences)

Visualizing neuronal dendritic architecture while simultaneously identifying specific neuronal phenotype is challenging. Here, we present a detailed description of the Immuno-Golgi technique which combines bromodeoxyuridine (BrdU) immunohistochemistry with Golgi impregnation. This straightforward and non-invasive approach enables the three-dimensional visualization and quantitative analysis of dendritic arborization and spine morphology in newborn neurons within the adult rodent brain.
Analysis of Shoreline Changes in Ikoli River in Niger Delta Region Yenagoa, Bayelsa State Using Digital Shoreline Analysis System (DSAS)

Field: Environmental Science (Physical Sciences)

The use of Digital Shoreline Analysis System was used to determine shoreline changes in Ikoli River, Yenagoa, Bayelsa State. Shoreline data were extracted from satellite imagery over thirty years (1991-2021). The basis of this study is to use Digital Shoreline Analysis System to determine erosion and accretion areas. The result reveals that the average erosion rate in the study area is 1.16 m/year and the accretion rate is 1.62 m/year along the Ikoli River in Ogbogoro Community in Yenagoa, Bayelsa State. The mean shoreline length is 5.24 km with a baseline length of 5.2 km and the area is classified into four zones to delineate properly area of erosion and accretion based on the five class of Linear regression rate, endpoint rate and weighted linear rate of which zone I contain very high erosion and high erosion with an area of landmass 255449.93 m2 of 38%, zone II contain moderate accretion, very high accretion and high accretion with a land area of 1666816.46 m2 with 24%, zone III has very high erosion and high erosion with an area of landmass 241610.85 m2 of 34 % and zone IV contain moderate accretion and high accretion with land area 30888.08 m2 with 4%. Out of the four zones, zone I and II were found to be eroding with 72% and zone II and IV contain accretion with 28%. The result shows that 44% of the area have been eroded. Therefore, coastal engineers, planners, and shoreline zone management authorities can use DSAS to create more appropriate management plans and regulations for coastal zones and other coastal parts of the state with similar geographic features.
Immunoreactivity of the 14F7 Mab raised against N-Glycolyl GM3 Ganglioside in retinoblastoma tumors

Field: Medicine (Health Sciences)

Introduction The identification of molecules expressed selectively on the surface of retinoblastoma cells would allow applying targeted therapies. The Ganglioside, N-Glycolyl-GM3 (NeuGc-GM3), is an attractive candidate, as it has been detected in other paediatric neuroectodermic tumours, and it is not expressed in human normal tissues. The 14F7 antibody recognizes specifically the ganglioside NeuGc-GM3. Purpose To characterize the expression of NeuGc-GM3 in retinoblastoma cell lines and in retinoblastoma tumours using the 14F7 monoclonal antibody. Methods We studied WERI-Rb1 and Y79 cell lines, 24 retinoblastoma primary tumours from unilateral and bilateral cases and two bone marrow biopsies from metastatic retinoblastoma. Tumours were classified into three groups: non-invasive (n = 13), invasive (n = 9) and metastatic (n = 2). Three eyes enucleated because of non-tumoural conditions were used as controls. Cell lines and tumour sections were studied by immunohistochemistry using the 14F7 antibody. NeuGc-GM3 expression was evaluated by analysing the percentage of positive tumoural cells and the staining intensity. These parameters were analysed comparatively among the three groups. Results Both retinoblastoma cell lines showed immunoreactivity to NeuGc-GM3 but WERI-Rb1 presented higher intensity than Y79. All the tumours studied showed strong immunoreactivity to NeuGc-GM3 with no significant differences among groups. In both bone marrow specimens, NeuGc-GM3 immunoreactivity was observed in retinoblastoma cells. In bilaterally enucleated cases, NeuGc-GM3 immunoreactivity was not altered before and after chemotherapy. Non-tumoural retinas were negative. Conclusions NeuGc-GM3 is highly expressed in retinoblastoma cell lines, tumours and metastatic cells to the bone marrow, and it is not detectable in control eyes. There were no significant differences in the immunoreactivity to 14F7 among tumours from different disease stages. Its immunoreactivity did not change after chemotherapy.
Solution of Inverse Dynamic Problem for Time-Variant Linear Object

Field: Engineering (Physical Sciences)

The paper deals with the developing of scientific backgrounds to design the control system for time-variant linear dynamical objects. These backgrounds are based on using the interval methods to transform time-variant models into interval time-invariant form. One can use control theory methods to perform the transformation of the designed model into the operator form. The proposed method allows us to describe a time-variant dynamical object by the interval differential equations with time-invariant factors. It is possible to define interval transfer functions for designed in such way models and one can use these transfer functions to define minimal and maximal controller's transfer function, which make it possible to transform control object into the desired form by solving an inverse dynamic problem and compensating object inner dynamic. We show various control methods can be used to control transformed object. We illustrate the usage of our methods by considering the example of controller design for UAV speed control.
Features of Quranic Text Decording as a Partly Dead Arabic Language

Field: Arts and Humanities (Social Sciences)

Purpose of the study. The purpose of the study is to systematize the meanings of words and cases of modification of grammatical categories of names and verbs based on the decipherment of the Koranic text. Materials and research methods. The sentences of the Koranic text were analyzed using a continuous sampling method within the framework of suras and verses. The research material is the text of the Koran. It should be noted that the earliest texts of the Qur'an in Arabic available in the world date back to 1400 years. The texts of letters with dots and vowels (haraka) date back 1200 years, they are fully consistent with the modern texts of the Qur'an distributed throughout the world in books and on the Internet (الكريم القرآن). The objects of the study were the meanings of words, changing the person of the verb, changing the tense or mood of the verb, changing the case of names, replacing one morphological structure with another, using a present tense verb in the imperative mood and vice versa, replacing an active participle with a passive participle and vice versa, modification of verb inflections. Based on scientific interest in the illogically composed ancient text, an attempt was made to systematize the meanings of words and cases of modification of grammatical categories throughout the text. Research results. It is noted that modern Arabic only partially corresponds to the language of the Quranic text of a thousand years ago. The reason for this is that the modern understanding of the meanings of many Quranic words is not systematized, that is, the same word in the text of the Quran can have several meanings, which are revealed not only from the context, but also from traditions about the messenger Muhammad (Hadis). It was revealed that in the works of researchers it is believed that the language of the text of the Quran is complex due to the fact that it was created on the basis of rhyme, incomprehensible logic of the text, or this text is encrypted. Because of this, it is generally accepted that the Quranic text is encrypted, the full decryption of which is known only to its author. The meanings of words and cases of modification of grammatical categories of names and verbs found in the text of the Koran are systematized. Conclusions. The text of the Koran is voluminous, which is why it is not possible to manipulate the meanings of words and inflections of the verbs of the text, since they are found in sentences with different meanings. It is concluded that contextual analysis is the most promising and optimal method for studying the text of the Koran, its translation, as well as systematization of linguistic phenomena, in particular, the meanings of words and modifications of grammatical categories.
Excessive daytime sleepiness in the elderly: association with cardiovascular risk, obesity and depression

Field: Medicine (Health Sciences)

OBJECTIVE: To observe the relationship between Excessive Daytime Sleepiness (EDS) and the presence of risk factors for cardiovascular dysfunction, depression and obesity in the elderly. METHODS: We interviewed 168 elderly from the community of Campina Grande, Paraíba. They were selected according to health districts in the period of 2010. We used the Epworth Sleepiness Scale to diagnose excessive daytime sleepiness (> 10 points); waist circumference for the risk of cardiovascular dysfunction (> 94 or > 80 cm); Geriatric Depression Scale for depression (>10 points) and body mass index for obesity (> 25 kg/m2). Association analysis was performed by the Chi-square test adjusted for sex and age group, adopting α < 0.05. RESULTS: One hundred and sixty eight elderly individuals with mean age of 72.34 ± 7.8 years old participated in this study, being 122 (72.6%) women. EDS was identified in 53 (31.5%) of them; depression, in 72 (42.9%); overweight/obesity, in 95 (64.46%); and risk of cardiovascular dysfunction, in 129 (79.6%). Depressed men (78.6%, p = 0.0005) and risk of cardiovascular dysfunction (57.1%, p = 0.02) were more prone to EDS. In women, only obesity was related to sleepiness (42.1%, p = 0.01). Only those aged between 70 - 79 years old showed association between sleepiness and obesity. CONCLUSION: It was found that obesity for women, and depression and cardiovascular dysfunction risking for men were associated with EDS in the elderly. The variable sex is a confusion condition for the association with sleepiness.