jimnoneill/paper-to-field-training huggingface dataset:
Effectiveness of Various Plant Crude Extract on Controlling Parasitic Ciliates (Colpoda sp.) Affecting Fishes

Field: Agricultural and Biological Sciences (Life Sciences)

Aquaculture plays a crucial role in the national economy of many countries. Ciliate protozoans are recognized as economically significant parasites in fish aquaculture. Colpodean ciliates are particularly abundant and are commonly found in terrestrial settings such as soils, leaf litter, and mosses. Diseases are recognized as significant impediments to sustainable animal production, leading to substantial economic losses, particularly in the aquaculture sector. Traditional medicinal plants offer a promising alternative for controlling various diseases in aquaculture. This study examined the efficacy of several plant extracts, including tobacco, neem paste, rue seeds, thyme seeds, and pepper seeds, in managing ciliates. Among the tested plant extracts, Colpoda cultures treated with rue seeds demonstrated the highest effectiveness.
Study on chromosome banding patterns of Verasper moseri

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The C-binding,Ag-NORs,and G-banding patterns of the metaphase chromosomes of barfin flounder Verasper moseri were investigated in this study.The results showed that the interstitial regions of most chromosomes exhibited positive C-bands,in which the whole 3rd,13th,20th,and 22nd pair of chromosomes showed totally positive C-band,whilst the 1st,4th and 8th pair of chromosomes only showed positive C-bands in the middle region,the rest with centromeric positive C-bands.However,the 9th pair of chromosomes showed negative result.The C-banding heretochromatin occupied 54.91% of the total chromosome in the present study.Silver staining study showed that most chromosomes featured two silver-stained nuclear organizing regions(Ag-NORs) with the percentage of 87.5%.Accordingly,the interphase nucleus with 2 nucleolus appeared most frequently,thus it is supposed that the barfin flounder bears a pair of Ag-NORs which located at the end of short arm of the submetacentric chromosomes.A total of 59 positive G-bands(37 strong,22 light) were recorded in 23 pairs of chromosomes.These results would provide basic data for the genomic research and biodiversity conservation of barfin flounder.
The Cost of Justice?

Field: Social Sciences (Social Sciences)

The recovery of party-party costs - that is, the recovery of costs incurred by a party in legal proceedings from another party in the proceedings - is governed in Australia by the indemnity principle. This principle states that a client must have an obligation to pay costs to a legal practitioner before those costs can be recovered from the other party in litigation. It might seem, then, that an order for party-party costs would be unproductive if made in favour of a party who is represented by lawyers acting pro bono, since they are not obliged to pay those lawyers' fees.
Pinpointing Novel Plasma and Brain Proteins for Common Ocular Diseases: A Comprehensive Cross-Omics Integration Analysis

Field: Medicine (Health Sciences)

The pathogenesis of ocular diseases (ODs) remains unclear, although genome-wide association studies (GWAS) have identified numerous associated genetic risk loci. We integrated protein quantitative trait loci (pQTL) datasets and five large-scale GWAS summary statistics of ODs under a cutting-edge systematic analytic framework. Proteome-wide association studies (PWAS) identified plasma and brain proteins associated with ODs, and 11 plasma proteins were identified by Mendelian randomization (MR) and colocalization (COLOC) analyses as being potentially causally associated with ODs. Five of these proteins (protein-coding genes ECI1, LCT, and NPTXR for glaucoma, WARS1 for age-related macular degeneration (AMD), and SIGLEC14 for diabetic retinopathy (DR)) are newly reported. Twenty brain-protein–OD pairs were identified by COLOC analysis. Eight pairs (protein-coding genes TOM1L2, MXRA7, RHPN2, and HINT1 for senile cataract, WARS1 and TDRD7 for AMD, STAT6 for myopia, and TPPP3 for DR) are newly reported in this study. Phenotype-disease mapping analysis revealed 10 genes related to the eye/vision phenotype or ODs. Combined with a drug exploration analysis, we found that the drugs related to C3 and TXN have been used for the treatment of ODs, and another eight genes (GSTM3 for senile cataract, IGFBP7 and CFHR1 for AMD, PTPMT1 for glaucoma, EFEMP1 and ACP1 for myopia, SIRPG and CTSH for DR) are promising targets for pharmacological interventions. Our study highlights the role played by proteins in ODs, in which brain proteins were taken into account due to the deepening of eye–brain connection studies. The potential pathogenic proteins finally identified provide a more reliable reference range for subsequent medical studies.
DTIC ADA002942: Analysis of a Proposed Two-Frequency Radar Waveform

Field: Engineering (Physical Sciences)

The report examines a proposed (unsuccessful) method for achieving frequency agility by radiating two frequencies which may take on any value from pulse to pulse, provided the mean frequency remains unchanged. On reception, the signals are combined so as to process the mean-frequency component. The receiver uses an envelope detector as well as a coherent reference at the mean frequency. It is shown that the signal received from a single echo depends only on the mean frequency and not on the difference. This gave encouragement to the idea that MTI processing could be undertaken even though the difference between the two-frequencies was changed pulse-to-pulse. Unfortunately, when clutter was considered, the phase of the processed signal was found to depend on the difference between the two frequencies. This gives rise to an uncancelled residue. Hence, this form of frequency agility is incompatible with MTI. It is possible, however, to use two or more widely spaced frequencies, either simultaneously or in time sequence, in a more conventional MTI system if the same frequencies are repeated.
Effects of F/sup -/ ions and F/sub 2/ molecules on the oscillation process of a discharge-pumped ArF excimer laser

Field: Physics and Astronomy (Physical Sciences)

Time-resolved number densities of the fluorine negative ion in a discharge-pumped ArF excimer laser are measured by a dye laser absorption method. The peak density of F/sup -/ is 0.93 /spl times/10/sup 15/ cm/sup -3/ at a total gas pressure of 2.5 atm, a gas mixture ratio of F/sub 2/-Ar-He=0.2-10.0-89.8, and a charging voltage of 28 kV for a 68-nF storage capacitor bank. The dependences of the peak F/sup -/ density and the ArF laser output power on the F/sub 2/ gas fraction in F/sub 2/-Ar-He mixture are investigated. The effects of F/sup -/ ions and F/sub 2/ molecules on the ArF laser oscillation process are discussed by considering the F/sub 2/ mixture-ratio dependences of particle densities, laser output power, mean electron energy, and laser power extraction efficiency. With increasing F/sub 2/ mixing ratio, the ArF* excimer formation first increases as F/sup -/ increases, but in F/sub 2/-rich conditions the laser power decreases because of the laser photon absorption due to F/sup -/ ions and quenching of ArF* with F/sub 2/ molecules.
Dendritic Cells Prime In Vivo Alloreactive CD4 T Lymphocytes Toward Type 2 Cytokine- and TGF-β-Producing Cells in the Absence of CD8 T Cell Activation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract The mechanisms that influence the polarization of CD4 T cells specific for allogeneic MHC class II molecules in vivo are still poorly understood. We have examined the pathway of alloreactive CD4 T cell differentiation in a situation in which only CD4 T cells could be activated in vivo. In this report we show that priming of adult mice with allogeneic APC, in the absence of MHC class I-T cell interactions, induces a strong expansion of type 2 cytokine-producing allohelper T cells. These alloantigen-specific CD4 T cells directly recognize native allogeneic MHC class II molecules on APC and secrete, in addition to the prototypic Th2 cytokines IL-4, IL-5, and IL-10, large amounts of TGF-β. The default Th2-phenotype acquisition is not genetically controlled and occurred both in BALB/c and C57BL/6 mice. CD8 T cells are the principal cell type that controls CD4 T cell differentiation in vivo. Furthermore, we demonstrate that strong Th2 priming can be induced not only with allogeneic splenocytes but also with a low number of bone marrow-derived dendritic cells. Finally, using a passive transfer system, we provide direct evidence that CD8 T cell expansion in situ promotes alloreactive Th1 cell development principally by preventing their default development to the Th2 pathway in a mechanism that is largely IFN-γ independent. Therefore, this work demonstrates that type 2 cytokine production represents a dominant pathway of alloreactive CD4 T cell differentiation in adult mice, a phenomenon that was initially thought to occur only during the neonatal period.
Anesthesia management of Jansen’s metaphyseal dysplasia

Field: Medicine (Health Sciences)

Metaphyseal chondrodysplasia is a rare autosomal dominant disorder characterized by accumulation of cartilage in specifically metaphysis of tubular bones.Hyperkalemia and hypophosphatemia were seen most of these patients.In this article we intended to draw attention to some issues releated with anesthesia hereby that a 9 year-old patient with Jansen's metaphyseal dysplasia.
A novel ferrochelatase inhibitor as a therapy for ocular neovascularization

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background and Hypothesis: Ocular neovascularization, characterized by the abnormal growth of new blood vessels, underlies blindness-inducing diseases such as wet age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). This neovascularization can be either choroidal (in the case of wet AMD) or retinal (in the case of PDR). Inhibition of vascular endothelial growth factor is the target of current FDA approved therapies, however the need for intravitreal injections poses a drawback to such treatments. Furthermore, many patients are non-responders or refractory. Given this, the discovery of novel therapeutic targets is warranted. Ferrochelatase (FECH) is an enzyme involved in heme synthesis. The Corson lab has previously shown FECH to be necessary for angiogenesis both in vitro and in vivo. The Corson lab has been successful in developing novel compounds that inhibit FECH in vitro, based on high-throughput screening hits. The objective of this project was to test one such novel FECH inhibitor in a choroidal neovascularization mouse model. Experimental Design: FECH inhibition was investigated in the laser-induced choroidal neovascularization model. This model involved creating a laser-induced lesion into the retinal pigment epithelium/choroid of mice aged 6-8 weeks; this promotes neovascularization. The FECH inhibitor compound was delivered once intravitreally at the time of the laser. Neovascularization was analyzed in vivo using optical coherence tomography and fluorescein angiography one and two weeks after laser, then quantified ex vivo by isolectin staining. Results: There was a trend toward decreased ocular neovascularization with the administration of a FECH inhibitor, as measured by optical coherence tomography seven days after laser treatment. However, further analyses are ongoing to validate this finding. Conclusion and Potential Impact: The administration of a FECH inhibitor compound intravitreally may result in a decrease in CNV. This may be useful as it could lead to FECH serving as a target for future therapies.
Knowledge and Attitude regarding Family Planning Methods among Postnatal mothers at Bishop Benziger Hospital, Kollam

Field: Health Professions (Health Sciences)

Introduction: a descriptive study was conducted to assess the knowledge and attitude regarding family planning methods among postnatal mothers at Bishop Benziger Hospital, Kollam. The objectives: of the study were to assess the knowledge regarding family planning methods among postnatal mothers, to assess the attitude regarding family planning methods among postnatal mothers, to correlate between knowledge and attitude of postnatal mothers regarding family planning methods, to find the association between knowledge score and selected demographic variables such as age, education, occupation, place of living, type of family, gravida and previous knowledge and to find the association between attitude score and selected demographic variables such as age, education, occupation, place of living, type of family, gravida and previous knowledge. Methodology: Purposive sampling was used to select 60 samples. Data were collected through structured questionnaire. Result: shows that 43.33% of the postnatal mothers possessed moderate knowledge and 56.67% of the postnatal mothers possessed adequate knowledge. Regarding the attitude 36.67% of the postnatal mother possessed moderate attitude and 63.33% of the postnatal mothers possessed adequate attitude. The Karl pearsons correlation coefficient was computed to determine the correlation between knowledge score and attitude score and the score was computed r=0.12 for a sample size of 60, shows weak positive correlations. Conclusion: There is a moderate knowledge regarding the family planning methods among postnatal mothers and they are trying to aware more about the newer methods in family planning methods.
Some new results on recursive aggregation rules

Field: Decision Sciences (Social Sciences)

As pointed by Cutello and Montero in a previous paper, consis tency of an aggregation rule based upon a sequence of binary opera tors can be justied from an operational argument, by imposing a recursive calculus. Following this recursive approach, it was later proven that under certain regularity conditions, strict increasingness leads to quasi-additive solutions. In this paper we propose an alternative and more general result, avoiding some of those regularity conditions. Moreover, we point out that in practice we should evaluate only those aggregations being allowed by the decision maker. Preference structures\n\t\t\t\t are considered as an illustrative example.
Development of a source of accelerated neutral particles for the final purification of dielectric substrates

Field: Physics and Astronomy (Physical Sciences)

The paper discusses approaches to the improvement of sources for receiving streams of accelerated neutral particles, applied for final purification of dielectric surfaces. It is revealed that the most effective method of neutralization is based on the reflection of ions from a solid surface with their subsequent recharge. In the present work novel approach to the design of an accelerated neutral particles generator and the results of the study of its main characteristics are shown. Also a consistent cleaning process of a borosilicate glass using a developed source is demonstrated.
Abstract 4146065: Sex Differences in Clinical Profile and Outcomes of Infective Endocarditis: A Meta-Analysis

Field: Medicine (Health Sciences)

Background: Infective endocarditis (IE) presents significant morbidity and mortality, with potential sex differences in clinical profile and outcomes. This meta-analysis aims to compare the clinical profile and outcomes of IE between males and females. Hypothesis: The clinical profile and outcomes of IE differ between males and females. Methods: We conducted a meta-analysis comparing the clinical profile and outcomes of IE in males versus females. Twelve studies were retrieved from PubMed, EMBASE, SCOPUS, and Cochrane databases up to January 1, 2024, with 9 studies reporting on patients admitted for IE and 3 studies reporting on patients who underwent surgery for IE. Results: Our meta-analysis revealed notable sex differences in the incidence and complications of IE. Males exhibited a higher incidence of aortic valve IE (RR 1.57; 95% CI [1.31, 1.88]), surgical indications for IE (RR 1.38; [1.12, 1.70]), Streptococci infection (RR 1.36; [1.04, 1.77]), intracardiac abscess (RR 1.22; [1.05, 1.42]), and Enterococci IE (RR 1.44; [1.28, 1.61]). In contrast, females had a higher incidence of mitral valve IE (RR 0.79; [0.67, 0.94]) and a higher in-hospital mortality rate (RR 0.84; [0.74, 0.96]). There were no major sex differences in the occurrence of valve vegetation, tricuspid valve IE, embolization, or Staphylococcus IE. Male patients had a longer in-hospital stay, although this was only marginally significant (RR 3.15; [-0.16, 6.45]; p = 0.06). Among patients who received surgery for IE, male patients had significantly lower mortality rates (RR: 0.67; [0.59, 0.76]; p<0.01). Conclusions: Compared to females, males exhibit higher rates of aortic valve IE, IE-related surgical indications, intracardiac abscesses, streptococci IE, and enterococci IE. In contrast, females have higher rates of mitral valve IE and in-hospital mortality. Conversely, the incidence of stroke, embolization, and in-hospital stay duration is comparable between both sexes.
Conclusion: Clinical social work practice in community‐based systems of care

Field: Social Sciences (Social Sciences)

Abstract The system of care concept and philosophy is considered as a dynamic means for preventing school violence and meeting the mental health needs of children and adolescents. It is vital that community‐based clinical social workers take leadership in collaborations that build systems of care. This paper examines the system of care paradigm in contrast to traditional mental health services for children, youth, and families. Examples of how systems of care are evolving and implications for developing community‐based clinical practice are presented as opportunities that would entail changing systems and practice paradigms.
Virtual Microscopy in Prostate Histopathology: Simultaneous Viewing of Biopsies Stained Sequentially With Hematoxylin and Eosin, and α-Methylacyl-Coenzyme A Racemase/p63 Immunohistochemistry

Field: Medicine (Health Sciences)

The technology for simultaneously viewing sequentially hematoxylin and eosin and IHC stained prostate biopsies can be readily used for educational purposes, as exemplified by our website, and along with the availability of rapid virtual slide scanners it can also be used for clinical diagnostics.
Study on the clinicopathologic significance and expression of SIRT1

Field: Medicine (Health Sciences)

Objective To investigate the expression of SIRT1 in gastric cardia carcinoma and its correlation with clinicopathologic features and patients' prognosis. Methods Tissue microarray (TMA) technique and immunohistochemistry stain were used to detect the expression of SIRT1,p53,and Ki67 in 176 cases of gastric cardia carcinoma tissues and 32 cases of normal gastric cardiac region tissues.Results The positive rate of SIRT1 expression in gastric cardia carcinoma cases was significantly higher than that in normal gastric cardiac region tissues (P0.01); in the 176 cases of gastric cardia carcinoma,the expression of SIRT1 in lymph node metastasis group was significantly higher than that in the group without lymph node metastasis(P0.01),which was positively correlated to TNM stage(P0.05); the protein levels of Ki67 in SIRT1 positive group were significantly higher than those in SIRT1 negative group(P0.05). In the 90 patients with complete follow-up information,the three-year survival rate and mean survival time of patients with positive SIRT1 expression were significantly lower than those of patients with negative SIRT1 expression (P0.05).Conclusion There exists overexpression of SIRT1 in gastric cardia carcinoma,and the high expression of SIRT1 is correlated with lymphatic metastasis,TNM stage,proliferative status and patients' prognosis. SIRT1 may be a biological parameter to evaluate the malignant degree of gastric cardia carcinoma and to forecast the patients' prognosis of gastric cardia carcinoma.
Linked collectors and determiners for: Two new species of Colombian Epigomphus (Odonata: Gomphidae).

Field: Agricultural and Biological Sciences (Life Sciences)

Natural history specimen data linked to collectors and determiners held within, "Two new species of Colombian Epigomphus (Odonata: Gomphidae)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/7fbdd6a3-8010-4616-965d-241515af8423 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/7fbdd6a3-8010-4616-965d-241515af8423. Formatted as a Frictionless Data package.
Synthesis, Cytotoxicity, Pan‐HDAC Inhibitory Activity and Docking Study of N‐(2‐Aminophenyl)‐2‐arylquinoline‐4‐ and N‐(2‐Aminophenyl)‐2‐arylbenzo[h]quinoline‐4‐carboxamides**

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract A series of new N‐(2‐aminophenyl)‐2‐arylquinoline‐4‐carboxamide and N‐(2‐aminophenyl)‐2‐arylbenzo[h]quinoline‐4‐carboxamide derivatives were designed and synthesized. The cytotoxicity of the synthesized compounds was investigated on three cell lines A549, HT‐29 and HCT116. The synthesized compounds, despite simple structures, displayed moderate to good cytotoxicity. Pan‐HDAC inhibitory activity of the synthesized compounds was evaluated on two cell lines, HT‐29 and HCT116, which displayed inhibitory activity (%) of 9.77–50.39 % on HT‐29 and 7.1–53.64 % on HCT116 cell line at concentrations of 100 μM. The compounds 11 h , 11 k , 11 l , 11 m , 12 b , 12 c and 12 e with the best cytotoxicity (%) and Pan‐HDAC inhibitory activity (%) were selected to determine IC 50 values. IC 50 values were calculated from 18.5–43.5 μM on HCT116 compared to 15.9 μM for CI‐994 and 35.5–75.9 μM on HT‐29 compared to 33.65 μM for CI‐994. Pan‐HDAC inhibitory activity of these compounds was more than 100 μM on HCT116 cell line except for compound 12 e (85.75±7.49 μM). Docking study of selected compounds ( 11 h , 11 k , 11 l , 11 m , 12 b , 12 c and 12 e ) was performed on HDAC isoforms that displayed the best docking scores on sirtuins.
Evaluation of the Slovenian Breast Cancer Screening Programme: Years of Life Gained and Avoided Deaths

Field: Medicine (Health Sciences)

Background: Most commonly, mortality is used for evaluation of organized breast cancer screening programmes. Survival analyses are also being employed to provide more timely assessment. A novel approach has been introduced for calculating survival using Slovenian data. Methods: Breast cancer cases from the Slovenian Cancer Registry between 2008–2021 in women aged 50 to 72 were included, supplemented by data on the screening history from the screening registry. The comparison was made in two scenarios—invited or not invited to the screening. Survival, years of life gained, and number of avoided deaths over 10 years were calculated and standardized. The comparison was adjusted for confounding covariates, and a biological tumour growth model was used to adjust the survival of the invited group for lead time bias and over-detection. Results: A total of 9392 breast cancer cases were included in the study. Estimated median lead time for screen-detected cases was 1.23 years. The survival probability accounting for lead time bias and covariates of cancers patients invited to the programme was 4.3 percentage points higher than the not invited (0.81 vs. 0.76). Standardized to 100,000 women in the 2-year period, this would result in 22 avoided deaths. On average, the invited cancer patient lived 0.22 years longer, which amounts to a total of 114 years of life gained. Conclusions: The results show the overall benefit of the breast cancer screening programme. The standardized results enable cross-country comparisons. The calculation of years of life gained and avoided deaths can provide additional opportunities for communicating the results to non-expert populations.