jimnoneill/paper-to-field-training huggingface dataset:
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS QUANTITATIVE ESTIMATION OF PREGABALIN, MECOBALAMIN AND ALPHA LIPOIC ACID IN CAPSULES

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Objective: To develop a simple, precise, accurate, linear and rapid Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method for the simultaneous quantitative estimation of Pregabalin 75mg, Mecobalamin 750µg and Alpha lipoic acid 100mg in capsules as per ICH guidelines. Methods: The optimized method uses a reverse phase C18 column, Enable Make C18G (250 X4.6mm, 5µm), mobile phase of a mixture of potassium dihydrogen orthophosphate buffer (20mM, pH adjusted to 6 using 0.1N potassium hydroxide solution), methanol and acetonitrile in ratio of 75:10:15v/v, flow rate of 1.2 ml/min and a detection wavelength of 210 nm using a UV detector. Results: The developed method resulted in pregabalin eluting at 2.6 min, mecobalamin eluting at 6.4 min and alpha lipoic acid eluting at 11.3 min. The method exhibited linearity over the range of 187.5-750µg/ml, 1.87-7.5µg/ml and 250-1000µg/ml for pregabalin, mecobalamin and alpha lipoic acid respectively. The method precision is exemplified by relative standard deviations of 0.84% for pregabalin, 1.07% for mecobalamin and 0.85% for alpha lipoic acid. Accuracy studies revealed % mean recoveries during spiking experiments between 98 and 102. The limit of detection was obtained as 3µg/ml for pregabalin, 800ng/ml for mecobalamin and 500ng/ml for alpha lipoic acid, while the limit of quantitation was obtained as 6 µg/ml for pregabalin, 2µg/ml for meocobalamin and 1.5µg/ml for alpha lipoic acid. Conclusion: A simple, precise, accurate, linear and rapid RP-HPLC method was developed and validated as per ICH guidelines and hence can be applicable in routine analysis for tablets in various pharmaceutical industries.
The mucopolysaccharidoses: characterization by cranial MR imaging.

Field: Medicine (Health Sciences)

Based on our observations, we postulate that in the natural course of MPS, cribriform changes occurred first, followed by white-matter changes and, last, atrophy. More severe degrees of cribriform changes plus involvement of the corpus callosum may suggest a poorer prognosis. Optimal therapeutic intervention may be at the time of cribriform changes before atrophy has occurred. MR can define and grade these changes.
Savings Groups, Risk Coping, and Financial Inclusion in Rural Areas

Field: Economics, Econometrics and Finance (Social Sciences)

This paper evaluates the impact of the introduction of savings groups on poverty, vulnerability, and financial inclusion outcomes in rural Peru. Using a cluster randomized control trial and relying on both survey and administrative records, we investigate the impact of savings groups after more than two years of exposure. We find t hat savings groups channel expensive investments such as housing improvements and reduce households' vulnerability to idiosyncratic shocks, particularly among households in poorer districts. The treatment also induces changes in households labor allocation choices: access to savings groups increases female labor market participation and, in poorer areas, it fosters greater specialization in agricultural activities. Access to savings groups also leads to a four-percentage point increase in access to credit among women, mainly driven by access to the groups loans. However, the introduction of savings groups has no impact on the likelihood of using formal financial services.On the contrary, it discourages access to loans from formal financial institutions and microfinance lenders among the unbanked.
Degradation of human immunoglobulins and cytotoxicity on HeLa cells by live Trichomonas vaginalis

Field: Immunology and Microbiology (Life Sciences)

The present study was undertaken to determine whether live T. vaginalis degrades human secretory IgA, serum IgA and IgG molecules. Human immunoglobulins were exposed to live trophozoites, parasite lysate, and excretory-secretory product (ESP) of T. vaginalis. To determine the fragmentation of immunoglobulins, the reaction sample was subjected to SDS-PAGE and EITB, and peroxidase conjugated antihuman IgA and IgG were used as probes. Live trophozoites degraded secretory IgA. Serum IgA and IgG, and degradation were pressed forward by the prolongation of the incubation time and by increasing the number of trichomonads respectively. Also the lysates and ESP of trichomonads degraded IgA and IgG. The cysteine and serine proteinase inhibitors such as E-64, antipain, iodoacetic acid, iodoacetamide, TLCK reduced the ability of cleaving immunoglobulins. The proteinase activity and cytotoxicity of T. vaginalis to HeLa cells were decreased when live T. vaginalis was treated with metallo-proteinase inhibitor as well as cysteine and serine proteinase inhibitors. These results suggest that proteinase secreted from live T. vaginalis may play a part role in host pathogenesis by T. vaginalis, and the cleaving ability of host immunoglobulins by the proteinase may contribute as a one of immune evasion mechanism for parasite survival in the host.
Is size an issue of time? Relationship between the duration of xylem development and cell traits

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Background and Aims Secondary growth is a process related to the formation of new cells that increase in size and wall thickness during xylogenesis. Temporal dynamics of wood formation influence cell traits, in turn affecting cell patterns across the tree ring. We verified the hypothesis that cell diameter and cell wall thickness are positively correlated with the duration of their differentiation phases. Methods Histological sections were produced by microcores to assess the periods of cell differentiation in black spruce [Picea mariana (Mill.) B.S.P.]. Samples were collected weekly between 2002 and 2016 from a total of 50 trees in five sites along a latitudinal gradient in Quebec (Canada). The intra-annual temporal dynamics of cell differentiation were estimated at a daily scale, and the relationships between cell traits and duration of differentiation were fitted using a modified von Bertalanffy growth equation. Key Results At all sites, larger cell diameters and cell wall thicknesses were observed in cells that experienced a longer period of differentiation. The relationship was a non-linear, decreasing trend that occasionally resulted in a clear asymptote. Overall, secondary wall deposition lasted longer than cell enlargement. Earlywood cells underwent an enlargement phase that lasted for 12 d on average, while secondary wall thickness lasted 15 d. Enlargement in latewood cells averaged 7 d and secondary wall deposition occurred over an average of 27 d. Conclusions Cell size across the tree ring is closely connected to the temporal dynamics of cell formation. Similar relationships were observed among the five study sites, indicating shared xylem formation dynamics across the entire latitudinal distribution of the species.The duration of cell differentiation is a key factor involved in cell growth and wall thickening of xylem, thereby determining the spatial variation of cell traits across the tree ring.
Molecular Characterization of an Infectious Bronchitis Virus Strain Isolated from an Outbreak in Vaccinated Layers

Field: Veterinary (Health Sciences)

An infectious bronchitis virus (IBV) strain CT/7852/97 was isolated from a commercial layer flock experiencing decreased egg production and poor egg quality. Reciprocal virus neutralization test demonstrated that the isolate was closely related to Massachusetts, Arkansas, and JMK. With the use of both reverse transcription-polymerase chain reaction-restriction fragment length polymorphism and multiplex polymerase chain reaction methods, results consistently showed that CT/7852/97 isolate was Massachusetts serotype specific only. The nucleotide sequence of S1 polypeptide coding region of CT/7852/97 was determined and compared with the published sequences of 12 IBV strains from North America. The highest nucleotide homology with H120 (97%) and the least homology (62%) with Delaware (De/072/92) were observed. Massachusetts 41 and Beaudette shared 94% and 93%, respectively, nucleotide similarity with CT/7852/97, and Connecticut, JMK, and Arkansas 99 had 94%, 83%, and 78%, respectively, nucleotide similarity with CT/7852/97. Furthermore, no possible recombination site on S1 gene among Massachusetts 41, Arkansas 99, and JMK was detected in the isolate.
A Pilot Study of Hydroxyurea in Hormone “Escaped” Metastatic Carcinoma of the Prostate

Field: Medicine (Health Sciences)

Summary— Twenty‐two patients with metastatic carcinoma of the prostate no longer responsive to hormonal therapy with stilboestrol 1 mg tds have been studied in a Phase II clinical trial of hydroxyurea 80 mg/kg body weight every third day after discontinuing their hormonal therapy. There was a partial objective response in 22.7%, a stable state response in 1 3.6% and a subjective response in a further 31.8%. The patients who showed a response to treatment survived longer than those who did not show a response and with a better quality of life. The response rate was higher in patients who started treatment without significant delay after diagnosis of relapse. Metastatic disease responded better than the primary tumour. Side effects were not a significant problem.
Extended-Spectrum ß-Lactamase-Producing Escherichia coli in Conventional and Organic Pig Fattening Farms

Field: Veterinary (Health Sciences)

Antimicrobial resistance is an increasing global problem and complicates successful treatments of bacterial infections in animals and humans. We conducted a longitudinal study in Mecklenburg-Western Pomerania to compare the occurrence of ESBL-producing Escherichia (E.) coli in three conventional and four organic pig farms. ESBL-positive E. coli, especially of the CTX-M type, were found in all fattening farms, confirming that antimicrobial resistance is widespread in pig fattening and affects both conventional and organic farms. The percentage of ESBL-positive pens was significantly higher on conventional (55.2%) than on organic farms (44.8%) with similar proportions of ESBL-positive pens on conventional farms (54.3–61.9%) and a wide variation (7.7–84.2%) on organic farms. Metadata suggest that the farms of origin, from which weaner pigs were purchased, had a major influence on the occurrence of ESBL-producing E. coli in the fattening farms. Resistance screening showed that the proportion of pens with multidrug-resistant E. coli was similar on conventional (28.6%) and organic (31.5%) farms. The study shows that ESBL-positive E. coli play a major role in pig production and that urgent action is needed to prevent their spread.
Natural Dye from Eucalyptus Leaves and Application for Wool Fabric Dyeing by Using Padding Techniques

Field: Agricultural and Biological Sciences (Life Sciences)

Natural dyes are known for their use in colouring of food substrate, leather, wood as well as natural fibers like wool, silk, cotton and flax as major areas of application since ancient times. Natural dyes have a wide range of shades that can be obtained from various parts of plants, including roots, bark, leaves, flowers and fruits (Allen, 1971). Since the advent of widely available and cheaper synthetic dyes in 1856 having moderate to excellent colour fastness properties, the use of natural dyes having poor to moderate wash and light fastness has declined to a great extent. However, recently there has been revival of the growing interest on the application of natural dyes on natural fibers due to worldwide environmental consciousness (Samanta & Agarwal, 2009). Although this ancient art of dyeing with natural dyeing with natural dyes withstood the ravages of time, a rapid decline in natural dyeing continued due to the wide available of synthetic dyes at an economical price. However, even after a century, the use of natural dyes never erodes completely and they are still being used. Thus, natural dyeing of different textiles and leathers has been continued mainly in the decentralized sector for specialty products along with the use of synthetic dyes in the large scale sector for general textiles owing to the specific advantages and limitations of both natural dyes and synthetic dyes. The use of non-toxic and ecofriendly natural dyes on textiles has become a matter of significant importance because of the increased environmental awareness in order to avoid some hazardous synthetic dyes. However, worldwide the use of natural dyes for the colouration of textiles has mainly been confined to craftsman, small scale dyers and printers as well as small scale exporters and producers dealing with high valued ecofriendly textile production and sales (Samanta & Agarwal, 2009; Bechtold & Mussak, 2009; Vankar, 2007). Recently, a number of commercial dyers and small textile export houses have started looking at the possibilities of using natural dyes for regular basis dyeing and printing of textiles to overcome environmental pollution caused by
Ashis Nandy, ed., The Secret Politics of Our Desires. Innocence, Culpability and Indian Popular Cinema

Field: Arts and Humanities (Social Sciences)

L’originalité de cet ouvrage consiste à envisager le cinéma comme un « analyste », c’est-à-dire un révélateur de la société indienne, et à puiser dans son réservoir populaire de scénarios et de « schémas sensori-moteurs » (Ashis Nandy) des outils pour renouveler l’approche traditionnelle du politique. L’auteur tient pour acquis que le cinéma en Inde a contribué, pendant plus d’un siècle, à façonner la conception qu’ont les classes moyennes du politique et de la société, mais « les sciences so...
Emotional Sea: Showing Valence and Arousal Through the Sharpness and Movement of Digital Cartoonish Sea Waves

Field: Computer Science (Physical Sciences)

This paper proposes and explores a nonanthropomorphic approach to express emotions. Emotions are represented in terms of valence and arousal dimensions, and they are visually expressed through the shape and movement of a series of digital cartoonish sea waves which are modeled as simple Bèzier curves. In particular, the valence value is expressed through the sharpness of the curves (the more negative the valence, the sharper the curves), while the arousal value is expressed through their movement (controlled by a flocking algorithm). Furthermore, this paper describes a user study which investigated whether the valence and arousal expressed by our model are appropriately perceived by the users or not. The results suggest that combinations of sharpness and movement are perceived correctly as particular emotions and that sharpness and movement are perceived as valence and arousal, respectively. We also found that valence in our model has a slight side effect in the perception of arousal. The more negative the valence, the higher the arousal is perceived.
MEDIA MERGERS AND PLURALISM IN PRESS, BROADCASTING AND INTERNET

Field: Social Sciences (Social Sciences)

The article has covered the analysis of media mergers and pluralism in the press, broadcasting and internet and the problematic in the face of competition rules and application of the Regulation, as well as the perspectives and improvements today. Works to redefine the concept of media and the adequacy of existing laws and their regulations including on anti-concentration measures Portugal, also as a member state of the European Union.
A clarithromycin sensitivity survey

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Journal Article A clarithromycin sensitivity survey Get access GEORGE N. ROLINSON GEORGE N. ROLINSON Parkgate House, Newdigate, Surrey, RH5 5DZ, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Antimicrobial Chemotherapy, Volume 34, Issue 3, September 1994, Pages 444–445, https://doi.org/10.1093/jac/34.3.444 Published: 01 September 1994
CCL17 Protects Against Viral Myocarditis by Suppressing the Recruitment of Regulatory T Cells

Field: Medicine (Health Sciences)

Background Viral myocarditis is characterized by leukocyte infiltration of the heart and cardiomyocyte death. We recently identified C‐C chemokine ligand (CCL) 17 as a proinflammatory effector of C‐C chemokine receptor 2–positive macrophages and dendritic cells that are recruited to the heart and contribute to adverse left ventricular remodeling following myocardial infarction and pressure overload. Methods and Results Mouse encephalomyocarditis virus was used to investigate the function of CCL17 in a viral myocarditis model. Ccl17 Gfp reporter and knockout mice were used to identify the cell types that express CCL17 and delineate the functional importance of CCL17 in encephalomyocarditis virus clearance and myocardial inflammation. Cardiac CCL17 was expressed in C‐C chemokine receptor 2–positive macrophages and dendritic cells following encephalomyocarditis virus infection. Colony‐stimulating factor 2 (granulocyte‐macrophage colony‐stimulating factor) signaling was identified as a key regulator of CCL17 expression. Ccl17 deletion resulted in impaired encephalomyocarditis virus clearance, increased cardiomyocyte death, and higher mortality during infection early stage, and aggravated hypertrophy and fibrotic responses in infection long‐term stage. An increased abundance of regulatory T cells was detected in the myocardium of injured Ccl17‐ deficient mice. Depletion of regulatory T cells in Ccl17‐ deficient mice abrogated the detrimental role of CCL17 deletion by restoring interferon signaling. Conclusions Collectively, these findings identify CCL17 as an important mediator of the host immune response during cardiac viral infection early stage and suggest that CCL17 targeted therapies should be avoided in acute viral myocarditis.
[Use of the deep femoral artery as the anastomotic site in proximal or distal bypass. Indications, technique, results of a series of 19 cases].

Field: Medicine (Health Sciences)

Atherosclerosis predominantly affects the ilio-superficial femoral axis, and tends to spare the deep femoral artery which can offer excellent outflow for proximal reconstructions for occlusive vascular disease of the lower limbs. Often symptoms are relieved and ischemic lesions can heal. The deep femoral artery can also provide good, pulsatile inflow for distal reconstructions when it is desirable to avoid the groin (either because of multiple previous dissections or because of infection). Occasionally two-level sequential bypasses to and from the deep femoral artery are required for multilevel disease where the groin is to be avoided. Over the past 4 years we have performed 190 arterial reconstructions (41 central, 125 distal and 24 sequential two-level procedures). 19 times the proximal, distal or intermediate anastomosis was on the deep femoral artery. Short- and long-term results were good in these difficult patients, with relief of symptoms or significant improvement in most patients. Two major (and no minor) amputations were ultimately required. Arterial reconstructions using the deep femoral artery cannot only salvage many limbs, but offer good symptomatic relief in patients who are not suitable for usual reconstructive procedures.
Property-Liability Company Exits: Comment

Field: Economics, Econometrics and Finance (Social Sciences)

In a recent issue of this Journal, Professor Robert E. Nelson examined the attrition rate among property-liability insurers with the goal of focusing on an area which may be ripe for exploration.' While the legitimacy of a scholarly article with so limited an objective may well be questioned,2 the purpose of this review is to point out a number of deficiencies in Professor Nelson's presentation. The article begins with the statement that A search of the current literature revealed that little or nor (sic) attention had been given to the matter of exits.3 While it may be true that there are no major studies on exits, per se, an important subcategory of the exit problem, i.e., insolvencies, has been examined by a number of researchers. One of the most comprehensive studies was conducted by H. T. Bishara.4 Although Bishara's study was not readily available to this author,
Talent allocation in the school-to-job transition

Field: Economics, Econometrics and Finance (Social Sciences)

This paper raises the problem of the optimal allocation of talent in a gendered perspective. It analyses the transition from education to labor market in Italy, and the way in which gender differences emerge early in the labor market career. Our data establish higher grades for females in both male and female type of courses on the one hand, and lower employment rate, lower entry wages, and under-representation in apical positions for women three years after graduation on the other. We explain female educational over-performance by means of signaling theory and under-utilization of female manpower by means of tournaments theory.
Stability of fentanyl citrate and midazolam hydrochloride during simulated intravenous coadministration

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Journal Article Stability of fentanyl citrate and midazolam hydrochloride during simulated intravenous coadministration Get access Varsha Bhatt-Mehta, Pharm.D., Varsha Bhatt-Mehta, Pharm.D. Clinical Assistant Professor of Pharmacy College of Pharmacy, University of Michigan (UM). and Clinical Pharmacist, Neonatal Intensive Care, University of Michigan Medical Center (UMMC), Ann Arbor Address reprint requests to Dr. Bhatt-Mehta at the Department of Pharmacy, F5205. 200 East Hospital Drive. University of Michigan Medical Center, Ann Arbor, MI 48109-0225. Search for other works by this author on: Oxford Academic Google Scholar Cary E. Johnson, Pharm.D., Cary E. Johnson, Pharm.D. Associate Professor of Pharmacy College of Pharmacy, UM, and Clinical Pharmacist, Pediatrics, UMMC Search for other works by this author on: Oxford Academic Google Scholar Nina Leininger, Pharm.D., Nina Leininger, Pharm.D. Pharmacist Evanston Hospital, Evanston, IL Search for other works by this author on: Oxford Academic Google Scholar Mona Agarwal, Pharm.D. Mona Agarwal, Pharm.D. Pharmacy Practice Resident University of Pennsylvania Hospital. Philadelphia, PA: at the time of this study they were Pharm.D. degree candidates at the College of Pharmacy, UM Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 52, Issue 5, 1 March 1995, Pages 511–513, https://doi.org/10.1093/ajhp/52.5.511 Published: 01 March 1995
SingNet: Towards a Large-Scale, Diverse, and In-the-Wild Singing Voice Dataset

Field: Computer Science (Physical Sciences)

The lack of a publicly-available large-scale and diverse dataset has long been a significant bottleneck for singing voice applications like Singing Voice Synthesis (SVS) and Singing Voice Conversion (SVC). To tackle this problem, we present SingNet, an extensive, diverse, and in-the-wild singing voice dataset. Specifically, we propose a data processing pipeline to extract ready-to-use training data from sample packs and songs on the internet, forming 3000 hours of singing voices in various languages and styles. Furthermore, to facilitate the use and demonstrate the effectiveness of SingNet, we pre-train and open-source various state-of-the-art (SOTA) models on Wav2vec2, BigVGAN, and NSF-HiFiGAN based on our collected singing voice data. We also conduct benchmark experiments on Automatic Lyric Transcription (ALT), Neural Vocoder, and Singing Voice Conversion (SVC). Audio demos are available at: https://singnet-dataset.github.io/.