jimnoneill/paper-to-field-training huggingface dataset:
Abstract 701: Characterization of two novel quinoline derivatives that induce apoptosis in a cancer-specific manner.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Many quinoline-based compounds possess pharmacological properties that are beneficial for the control of various human diseases, including microbial infections, inflammatory-related disorders, cardiovascular conditions, and cancer. The anticancer activities of quinoline compounds are often rendered by their property of inhibiting protein kinases, proteasome activity, tubulin polymerization/depolymerization and DNA repair. To further improve the efficacy and specificity, we created and characterized several quinoline derivatives, which led us to identify CTRI-17 and CTRI-20 as promising leads. We examined their anti-proliferative properties using three human breast cancer cell lines (MDA-MB-468, MDA-MB-231 and MCF-7) and two matching non-cancer breast cell lines (184B5 and MCF10A). In addition, we also examined their efficacy using one leukemic cell line (K-562) and one cervical cell line (HeLa). Data from this study showed that the IC50 values of CTRI-17 and CTRI-20 were 0.1-0.3 μM and 1.2-2.4 μM ranges on cancer and non-cancer cell lines, respectively. Thus, both CTRI-17 and CTRI-20 killed cancer cells 10-20 times more effectively than non-cancer cells. This differential cell killing effects on cancer and non-cancer cells is a highly desirable property for potential anticancer therapeutics. We further found that cancer cells treated with the two compounds resulted in increases of pro-apoptotic proteins such as p53 and Bax, and decreases of anti-apoptotic proteins such as Bcl-2 and survivin. Our data obtained from flow cytometry and confocal microscopy showed that CTRI-17 and CTRI-20 induced prolonged cell cycle arrest at G2/M phase prior to causing apoptosis in cancer cells. However, the two compounds neither induced substantial cell cycle arrest nor caused high levels of apoptosis in non-cancer cells at the same drug concentration. We are currently in the process of determining the detailed functional mechanisms of CTRI-17 and CTRI-20. Citation Format: Indeewari K. Lindamulage, Hai-Yen Vu, Yi-Fang Lee, Hoyun Lee, Piyush Trivedi. Characterization of two novel quinoline derivatives that induce apoptosis in a cancer-specific manner. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 701. doi:10.1158/1538-7445.AM2013-701
Rattlesnake Design in Yokuts Basketry

Field: Arts and Humanities (Social Sciences)

In 1906, Edward S. Curtis received funding from J.P. Morgan to begin work on "The North American Indian," a twenty volume set of photographs and text documenting Native American tribes throughout the western United States. The fourteenth volume, featuring the Kato, Wailaki, Yuki, Pomo, Wintun, Maidu, Miwok and Yokuts tribes, was published in 1924. The index provides more detailed captions for selected images within the portfolio.
Targeted Treatment of Renal Cell Carcinoma

Field: Medicine (Health Sciences)

The management of patients with metastatic RCC (mRCC) has been completely changed in the last decade by the introduction of novel molecularly targeted approaches. Although partial or radical nephrectomy still remains the standard approach for patients with localized RCC, systemic therapies are recommended in patients with mRCC. Till 2005, cytokine therapies represented the gold standard but were associated with a poor toxicity profile and a low response rate. Successively, the growing knowledge of the key role of angiogenesis in the development and progression of mRCC has led to the development of several targeted agents, which have increased the life expectancy of these patients. In this chapter, we describe the main agents currently used into daily clinical practice and the results of the clinical studies that have led to their approval in patients with mRCC.
Follow-up Study after Atrial Switch Operation for Complete Transposition of the Great Arteries

Field: Medicine (Health Sciences)

Background:Since the introduction of atrial switch operation, the outlook for patients with complete transposition of the great arteries (TGA) has improved dramatically. However, many survivors are afflicted with postoperative complications and continue to demand medical attention. We therefore performed the study for the evaluation of the clinical course in the patients with complete TGA after atrial switch operation. Methods:We analyzed the data of 51 patients who underwent the atrial switch operation for complete TGA at Seoul National University Hospital between January 1981 and June 1993 retrospectively. Results:The patients were composed of 36 males and 15 females (mean age at operation, 15±30 months, range 2 months18 years). Senning operation was undertaken in 43 and Mustard operation in 8. Among these, 27 had simple and 24 complex complete TGA. The early mortality rate within 1 month postoperatively was 39% and the late mortality rate 16%. The actuarial survival rate after 10 years was 78%. Of these, 17 cases have been followed up so far. Although the significant tricuspid regurgitation was noted in 9, right ventricular systolic function was maintained in all of them. Preoperative sinus node dysfunction was noted in 1 case. Postoperatively, premature ventricular contractions were found in 8 cases, atrial flutter in 4, and sinus node dysfunction in 7. Subclinical pulmonary venous obstruction was found in 2 and systemic venous obstruction in 1. At present, one takes digoxin for prevention of atrial flutter and 7 take digoxin, furosemide, and/or angiotensin-converting enzyme inhibitors for prevention of ventricular functional deterioration. Twelve cases were in New York Heart Association functional class I at the latest follow-up and 5 were in class II. Conclusion:This study revealed that morbidity and mortality were not low after atrial switch operation. However, considering the good longterm functional status in the survivors, atrial switch operation could be an alternative to arterial switch operation in complicated cases of TGA. (Korean Circulation J 1998;28(4):683-690)
Investigation of Fiber Optic Cables Installation Conditions on the Support Infrastructure of Overhead MV/LV Substations and Power Supply Cables

Field: Engineering (Physical Sciences)

Initially, the paper involves a thorough analysis and documentation of international literature (research publications, global standards like IEEE, European standards like EN, experimental outcomes, etc.), along with existing studies conducted by the Hellenic Distribution Network Operator (HEDNO) on these topics. Subsequently, there will be a comparative assessment between the international findings and Greek standards and regulations regarding these matters. The final stage includes presenting a substantiated and detailed recommendation for each technical issue. Where feasible, an optimal proposal for fiber optic cable installation is developed for each case, ensuring technical compliance with all constraints.
UAV-based Studies of Temperature and Wind in and above a Deciduous Forest (and a Forest Clearing) in the Region of the Weser Valley

Field: Environmental Science (Physical Sciences)

Between the German cities of H&#246;xter and Holzminden, the landscape ascends in the eastern direction from the Weser river at roughly 100 m a.s.l. up to 500 m a.s.l. in the Solling natural area. The slope is forested with deciduous trees with a typical height of approx. 30 m. In order to study the vertical profiles of temperature and wind in the forest, we operated an Unmanned Aerial Vehicle (UAV) flying from ground level up to approx. 100 m agl. Fifteen flights near sunset between summer 2019 and spring 2020 are analysed revealing effects of the foliation and downslope flows. Using rough estimates of turbulent fluxes and sensible heat and momentum based on the vertical profiles allows us to produce leaf area density profiles for the leafy and the leafless case. We compare the results with existing theories both for the average structure of the forest and the vertical profiles.For the cases studied here, the forest exerts a drag on the wind and the wind decreases markedly in a 30-m-layer above the canopy. The drag is maximal at the upper canopy and the presence of the leaves increases this effect. Due to the slope situation, downslope flows can be detected and enhance the mixing near the surface. Based on the work by Yi [1] we can split the wind speed into contributions from the forest and the slope.The estimation of turbulent fluxes is rough due to the limited data sample during the flights, but it is in agreement with the profiles of the mean variables. The momentum fluxes as a function of height allows the estimation of the profile of leaf area density as a fingerprint of the average structure of the forest. The results show that for a two storeys forest as present in the our region of interest, assuming a logarithmic profile of the variables does not reflect the measurements.&#160;[1] C. Yi, R. K. Monson, Z. Zhai, D. E. Anderson, B. G. Allwine, A. A. Turnipsseed, S. T. Burns: Modeling and measuring the nocturnal drainage flow in a high-elevation, subalpine forest with complex terrain. Journal of Geophysical Researcj, Vol. 110, D22303 (2005)
Investigation of microbial contamination on the surface of meat chopping blocks in Hefei food market

Field: Immunology and Microbiology (Life Sciences)

Objective:To understand the microbial contamination on the surface of meat chopping blocks in food markets.Methods:Referring to the related national standards,total number of bacteria,mold and yeast and Coliform bacteria on the surface of chopping blocks were detected individually.Results:All three kinds of microbes were detected in all samples;For the most light contaminated meat chopping board,the value of total number of bacteria was 43 CFU/cm2,mold and yeast was 17 CFU/cm2,Coliform bacteria was 19 CFU/cm2;For the most serious contaminated chopping board,the values of the three microbes were 2500 CFU/cm2,1300 CFU/cm2,40 CFU/cm2,respectively.The microbial contamination of the chopping boards covered with a carton board was more severe than that of the wood.Conclusion:The government must set and implement the hygiene standards for meat chopping blocks in food markets as soon as possible to eliminate potential threats on human health.
Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Medellín, Colombia

Field: Medicine (Health Sciences)

Approximately 5% of all breast cancers can be attributed to a mutation in the BRCA1 or BRCA2 gene. The genetic component of breast cancer in Colombia has been, for the most part, studied on cases from the Bogota region. Five different founder mutations were in two studies of breast cancer patients in the Bogota region. It is important that the frequency of mutations be established among unselected cases of breast cancer of other regions of Colombia in order to estimate the genetic burden of this cancer in Colombia and to plan genetic services. The aim of this study was to establish the mutation frequencies of the BRCA genes in breast cancer patients unselected for family history or age, from Medellin, Colombia.We enrolled 280 unselected women with breast cancer from a large public hospital in Medellin, Colombia. A detailed family history from each patient and a blood sample was obtained and processed for DNA analysis. Mutations in BRCA1 and BRCA2 were sought using a combination of techniques including a panel of recurrent Hispanic BRCA mutations which consists of fifty BRCA1 mutations and forty-six BRCA2 mutations, including the five recurrent Colombian BRCA mutations. All mutations were confirmed by direct sequencing.Genetic testing was successfully completed for 244 of the 280 cases (87%). Among the 244 cases, three deleterious mutations were identified (two in BRCA1 and one in BRCA2) representing 1.2% of the total. The average age of breast cancer in the mutation-positive cases was 34 years. The two BRCA1 mutations were known founder mutations (3450del4 in exon 11 and A1708E in exon 18). The BRCA2 mutation was in exon 11 (5844del5) and has not been previously reported in individuals of Colombian descent. Among the three mutation-positive families was a breast cancer family and two families with no history of breast or ovarian cancer.The frequency of BRCA mutations in unselected breast cancer cases from the Medellin region of Colombia is low and is approximately 1.2%.
Imputation-powered whole-exome analysis identifies rare coding variants and genes associated with kidney function and disease in the UK Biobank

Field: Medicine (Health Sciences)

Abstract Genome-wide association studies have discovered hundreds of associations between common genotypes and kidney function but cannot comprehensively investigate rare coding variants. Here, we applied a genotype imputation approach to whole exome sequencing data from the UK Biobank to increase sample size from 166,891 to 408,511. We detected 158 rare variants and 105 genes significantly associated with one or more of five kidney function traits, including genes not previously linked to kidney disease in humans. The imputation-powered findings derive support from clinical record-based kidney disease information, such as for a novel splice allele in PKD2 , and from functional studies of a novel frameshift allele in CLDN10 . This cost-efficient approach boosts statistical power to detect and characterize both known and novel disease susceptibility variants and genes, can be generalized to larger future studies, and generates a comprehensive resource (https://ckdgen-ukbb.gm.eurac.edu/) to direct experimental and clinical studies of kidney disease.
Adenomatoid odontogenic tumours in Ibadan, Nigeria.

Field: Dentistry (Health Sciences)

Only a few reports of adenomatoid odontogenic tumour (AOT) in Africans have been published. Clinical, histological and radiographic features as well as treatment results of thirteen new cases of AOT seen at the University College Hospital, Ibadan were reviewed. This lesion constituted 12.1% of odontogenic tumours. This study shows a male: female ratio of 1.2:1. This contrasts with the reported male: female ratio of 1:3 in the United States, Britain, Sri Lanka and Japan. The higher male incidence may be peculiar to Nigeria. Although the peak incidence was in the second decade of life, four patients were over 20 years of age. The mean age was 23.2 years for all patients. None of the patients presented with recurrence on follow up.
Attitudes toward Contraception Initiation in the Emergency Department among Providers and Patients

Field: Health Professions (Health Sciences)

Background and Hypothesis: In 2011, 45% of 6.1 million pregnancies were unintended. Women between the ages of 20-24, those with lower education, lower income, and of African American descent had higher rates of unintended pregnancies.i In 2014, there were 25.9 million visits to the ED by women under the age of 24.ii Intervention within the Emergency Department to assess fertility status and provide contraception when appropriate has the potential to help reduce the number of mistimed and unwanted pregnancies. Experimental Design or Project Methods: This study aims to assess the attitudes toward providing contraception within the Emergency Department via surveys. The provider survey will be sent through a large national list serve; the patient survey was given to women 18-45 years old within the Emergency Departments of a large county hospital and inner-city urban hospital. Results: So far, 200 surveys were collected. 32 women were planning to get pregnant within the next year, 135 were not attempting to get pregnant, 13 were unsure, and 20 could not get pregnant. The number of women who were unsure or did not want to get pregnant totaled to 148; out of these women, 62% showed interest in receiving access to birth control within the ED. We still plan to do more data analysis, including how many of these women are currently using birth control and demographic analysis looking at race, education level, and relationship status. Conclusion and Potential Impact: If there is substantial interest, we will then conduct a study to initiate contraception within the ED. This will hopefully contribute to reducing the unintended pregnancy rate.
Dinamika Politik Dalam Pendirian Dan Pengelolaan BUMDes: Studi Pada Tiga BUMDes Terbaik Jawa Timur

Field: Social Sciences (Social Sciences)

Research on the best practices of BUMDes establishment and management has practical significance for providing advice to BUMDes practitioners and the government. Academically, the significance of this research is expected to contribute to the development of the concept of good village governance, especially in the aspect of the network between governance actors in the context of the BUMDes. This study aims to describe the political dynamics in the formation and management, as well as identify best practices for the formation and management of BUMDes. This study is important considering that since the enactment of Law no. 6 of 2014, BUMDes placed as a facilitator of village progress and autonomy. To see these dynamics, qualitative research was conducted with informants including government actors in three BUMDes in East Java, namely BUMDes Podho Joyo in Gresik, Makmur Abadi in Pacitan, and Aneka Usaha in Bojonegoro. The results showed the dominant role of the supra-village government in the process of forming the three BUMDes, that is a combination of reactions to central government regulations accompanied by capital and assistance by the local government. In the management aspects, the work of the three BUMDes is relatively able to meet the needs of village community, especially in BUMDes Podho Joyo in Gresik. However, the existence of each BUMDes cannot be separated from the strong control of the BUMDes director. Research on the best practices of BUMDes establishment and management has practical significance for providing advice to BUMDes practitioners and the government. Academically, the significance of this research is expected to contribute to the development of the concept of good village governance, especially in the aspect of the network between governance actors in the context of the BUMDes. This study aims to describe the political dynamics in the formation and management, as well as identify best practices for the formation and management of BUMDes. This study is important considering that since the enactment of Law no. 6 of 2014, BUMDes placed as a facilitator of village progress and autonomy. To see these dynamics, qualitative research was conducted with informants including government actors in three BUMDes in East Java, namely BUMDes Podho Joyo in Gresik, Makmur Abadi in Pacitan, and Aneka Usaha in Bojonegoro. The results showed the dominant role of the supra-village government in the process of forming the three BUMDes, that is a combination of reactions to central government regulations accompanied by capital and assistance by the local government. In the management aspects, the work of the three BUMDes is relatively able to meet the needs of village community, especially in BUMDes Podho Joyo in Gresik. However, the existence of each BUMDes cannot be separated from the strong control of the BUMDes director.
Usulan Strategi Promotion Mix dan Brand Image Operator Selular AXIS (Studi Kasus CV.Sinar Matahari Sumedang)

Field: Business, Management and Accounting (Social Sciences)

Teknologi modern menjadi salah satu motivasi untuk mengembangkan perusahaan dan membuat perusahaan baru. AXIS merupakan produk operator selular GSM dari perusahaan baru yang ada di Indonesia. CV. Sinar Matahari bekerja sama dengan AXIS sejak 26 September 2008 sebagai distributor lokal AXIS untuk wilayah kabupaten Sumedang yang bertanggung jawab atas kegiatan
pemasaran dan distribusi starter pack AXIS dan isi ulang AXIS. CV. Sinar Matahari belum memenuhi target penjualan, dimana target yang harus dipenuhi untuk starter pack adalah 2000-2350 unit/bulan sedangkan rata-rata penjualan sebesar 82,09% dari target, dan target untuk masing-masing jenis voucher isi ulang 1200 unit/bulan sedangkan sedangkan rata-rata penjualan sebesar 77,24% dari target. Tujuan dari penelitian ini adalah untuk mengetahui faktor-faktor yang mempengaruhi konsumen dalam memilih operator selular, mengetahui citra AXIS
dibandingkan dengan pesaingnya (pesaing berdasarkan data dari perusahaan) yaitu Simpati dan IM3, serta memberikan usulan kepada perusahaan untuk perbaikan bauran promosi. Penyusunan kuesioner menggunakan variabel-variabel brand image yang terdiri dari brand association (asosiasi merek) dan favorability, strength and
uniqueness of brand association (sikap positif, kekuatan dan keunikan merek), dan bauran promosi yang terdiri dari iklan,acara khusus dan pengalaman, sales
promotion, public relations, dan personal selling. Teknik pengumpulan data yang digunakan adalah dengan wawancara kepada pihak perusahaan dan penyebaran kuesioner kepada konsumen yang pernah dan masih menggunakan AXIS.
Penyebaran kuesioner terdiri dari kuesioner pendahuluan sebanyak 30 responden dan kuesioner penelitian sebanyak 97 responden. Teknik sampling yang digunakan adalah sampling purposive (ukuran sampel dengan menggunakan
rumus Hadari Nawawi). Metoda pengolahan data yang digunakan adalah uji hipotesis untuk mengetahui kepuasan konsumen, Important Performance Analysis (IPA) untuk menentukan prioritas peningkatan kualitas, dan Correspondence Analysis (CA)
untuk menggambarkan posisi AXIS terhadap pesaingnya (Simpati dan IM3). Analisis gabungan dilakukan untuk menentukan prioritas perbaikan. Usulan dibuat berdasarkan prioritas perbaikan, dimana prioritas perbaikan pertama untuk faktor brand image diantaranya memaksimalkan penyebaran AXIS di wilayah yang memiliki jaringan cukup baik, untuk faktor iklan diantaranya memperbaiki waktu penayangan iklan di koran Sumedang expres, dan untuk faktor salles promotion adalah memberikan potongan harga. Prioritas kedua untuk faktor iklan adalah menentukan ide-ide yang kreatif untuk melakukan penayangan iklan, dan untuk faktor personal selling adalah memberikan training kepada
seller.