jimnoneill/paper-to-field-training huggingface dataset:
Evaluation of the Microbial Safety of Child Food of Animal Origin in Greece

Field: Immunology and Microbiology (Life Sciences)

Abstract Foodborne illness is a major cause of morbidity and mortality especially for children, even in the developed world. The aim of this study was to assess the microbial safety of food of animal origin intended for consumption by children in Greece. Sampling involved 8 categories of retail products and was completed with a collection of 850 samples. These were tested by PCR and/or culture for Listeria monocytogenes , Campylobacter spp., Escherichia coli O157, Salmonella spp., Cronobacter sakazakii , Brucella spp., and Mycobacterium avium subsp paratuberculosis (MAP). The number of positive results recorded collectively for the pathogens under investigation over the total number of samples tested was 3.52% and 0.12% by PCR and culture, respectively. The most frequently detected pathogen was enterohemorrhagic E. coli (1.29%) followed by Brucella (0.82%) and Listeria (0.82%). DNA belonging to MAP was detected in 0.35% of samples, which was also the percentage of positivity recorded for Campylobacter . The percentage for Salmonella was 0.12%. It can be concluded from the results that there is no indication of noncompliance for the tested food samples. However, detection of DNA belonging to pathogens that are transmissible to humans through food is indicative that constant vigilance regarding food safety is an absolute necessity.
Sieving Studies in ‘Urea-Induced Nephropathy’ in the Dog

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

1. The intrarenal infusion of concentrated urea after clamping of the renal artery produced immediate proteinuria in the dog. The predominant lesion on ultramicroscopy was destruction of the epithelial layer. Colloidal iron staining showed decreased fixed anionic charges in the capillary wall. 2. Sieving studies with neutral macromolecules such as 125I-labelled polyvinylpyrrolidone and [3H]-dextran or an electronegatively charged polymer, [3H]dextran sulphate, showed a moderate increase in permeability to the neutral tracers and a much more severe alteration of the electrostatic barrier to the anionic polymer. The fractional clearance of dextran sulphate molecules increased to a greater extent than clearance of neutral dextrans of comparable size. 3. The shape of the curve relating the fractional clearance of dextran sulphate to molecular size is also modified in the contralateral kidney. This may be due to elevated plasma angiotensin II concentrations.
Dating and Disclosure for Cancer Survivors

Field: Medicine (Health Sciences)

Forming intimate emotional and sexual relationships is a highly meaningful aspect of human life. In the process of creating such relationships, individuals inevitably reveal themselves – their personal histories, identities, emotions, thoughts, and bodies. Yet for cancer patients and survivors, such disclosures are complicated by the effects of cancer. For cancer survivors not involved in established committed relationships, the process of dating and disclosure becomes new and uncharted territory marked by uncertainty. Negative feelings about their bodies and sexuality, discomfort in communicating about cancer, and fear of negative reactions to their cancer may lead some survivors to avoid relationships or remain in unsatisfying ones rather than risk telling new potential partners about their cancer. Such issues may lead survivors to feel deprived of fulfilling companionship, support, and intimate relations with a partner.
On the Art of Narrating in the Writing of 《A Madman's Diary》

Field: Arts and Humanities (Social Sciences)

《A Madman's Diary》 is written by Lu Xun in the diary type of writing and is the first novel in the vernacular in China's modern literary. This paper, from the angle of narrative, analyses the key to the success of novel writing on the art of narrating, i.e. the mode of the first person narrating gives monologue novel a quality and style of objevtivity and expresses profound ideologival content of the work.
Ancient Umbria

Field: Arts and Humanities (Social Sciences)

Abstract How should we understand the ways in which the regions of Italy were affected by Roman imperialism? This book, which is the first full-scale treatment of ancient Umbria in any language, takes a balanced view of the region's history in the first millennium BC, focusing on local actions and motivations as much as the effect of outside influences and Roman policies. Through a careful reading of all the types of evidence it provides an important challenge to traditional treatments emphasising the 'Romanization' of the region, arguing that this is a poor explanation for the complexity of local societies in the late Republican period. Instead it proposes that other trends, particularly the organization of states, help to explain the fascinating plurality of identities that are evident in the imperial period and allow us to appreciate the diversity of local societies that emerged in both mountain and lowland areas of Umbria.
In-Place Stability and Deterioration of Structures.

Field: Engineering (Physical Sciences)

Most old lock and dam structures do not meet current design requirements for stability. Since it is important that current stability requirements are met to assure structural safety, most of these structures must be modified to increase their resistance to sliding and overturning. These modifications are very expensive and could possibly be avoided if a more exact stability evaluation could be determined. A brief summary of conventional stability evaluations and some comments about their strengths and weaknesses are presented.
Quantum integrable systems and special functions

Field: Mathematics (Physical Sciences)

The wave functions of quantum Calogero-Sutherland systems for trigonometric case are related to polynomials in l variables (l is a rank of root system) and they are the generalization of Gegenbauer polynomials and Jack polynomials. Using the technique of κ-deformation of Clebsch-Gordan series developed in previous authors papers we investigate some new properties of generalized Gegenbauer polynomials.Note that similar results are also valid in A_2 case for more general two-parameter deformation ((q,t)-deformation) introduced by Macdonald.
Vascular imaging: changing the face of cardiovascular research

Field: Medicine (Health Sciences)

Patients with systemic lupus erythematosus (SLE) are at significant risk for premature cardiovascular disease, now a leading cause of death in this population. Most previous studies have used an overt clinical event to identify cardiovascular disease, likely underestimating the actual prevalence in these patients. Although the rates of myocardial infarction in SLE are high, the actual number of coronary events is low, precluding large clinical trials using a coronary event as the sole outcome. The ability to measure atherosclerosis, a known determinant of coronary heart disease, provides investigators with a desirable surrogate for the clinical cardiac event. With the advent of sensitive imaging techniques to identify subclinical atherosclerosis, we are now better equipped to determine the true prevalence and mechanisms of vascular disease in SLE. In this review, we will discuss several vascular imaging techniques and the current trend away from measuring flow-limiting vessel stenosis toward measuring earlier structural and functional aspects of the vascular system.
Mineral-Rich Brines from Portuguese Coastal Lagoons: Insights into Their Use in Thalassotherapy and Skin Care

Field: Environmental Science (Physical Sciences)

This study characterized saline waters from traditional and semi-industrial saltpans located in the Ria Formosa and Ria de Aveiro Portuguese coastal lagoons, aiming to evaluate their potential for thalassotherapy and dermatological applications. Five saline water samples were collected and analyzed for physicochemical parameters (pH, electrical conductivity, dissolved oxygen, and total dissolved and suspended solids) and chemical composition (major, minor, and trace elements), complemented by SEM-EDS analyses of the suspended solids. All samples exhibited salinities above 70 g/kg, classifying them as mineral-rich brines. Sodium was the dominant element, followed by Mg, K, and Ca, with concentrations significantly higher than those of seawater. Apparent geochemical differences were observed between the two lagoons, with Ria de Aveiro water enriched in Ca, while Ria Formosa showed higher Mg and K contents. Suspended solids were composed mainly of halite, gypsum, K-Mg salts, and biogenic aggregates, reflecting the interaction between evaporitic and microbial processes. These findings highlighted the high therapeutic potential of Portuguese saline waters for skin-related applications, supporting the safe use of natural saline resources in evidence-based wellness and dermatological practices.
Synthesis and Biological Evaluation of New Ligustrazine Derivatives as Anti-Tumor Agents

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

To discover new anti-cancer agents with multi-effect and low toxicity, a series of ligustrazine derivatives were synthesized using several effective anti-tumor ingredients of Shiquandabu Wan as starting materials. Our idea was enlightened by the “combination principle” in drug discovery. The ligustrazine derivatives’ anti-tumor activities were evaluated on the HCT-8, Bel-7402, BGC-823, A-549 and A2780 human cancer cell lines. In addition the angiogenesis activities were valued by the chick chorioallantoic membrane (CAM) assay. 1,7-bis(4-(3,5,6-Trimethylpyrazin-2-yl)-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (4) and 3 α,12 α-dihydroxy-5β-dholanic acid-3,5,6-trimethylpyrazin-2-methyl ester (5) not only displayed antiproliferative activities on these cancer cells, but also dramatically suppressed normal angiogenesis in CAM. The LD50 value of the compound 5 exceeded 3.0 g/kg by oral administration in mice.
Effect of dietary protein levels on body pigmentation,growth and immunology of ornmmental carp(Cyprinus carpio L.)

Field: Agricultural and Biological Sciences (Life Sciences)

The study was to reasearch effects of dietary protein levels on body pigmentation,growth and immunology of ornmmental carp(Cyprinus carpio L.)(initial mean body weight: 5.85±0.19 g).The diet contained 12% Spirulina: Fish was fed with different protein levels(25.65%,30.43%,35.56%,40.42%,45.90%) and fed to apparent satiety to these groups of 20 fish for 60 days.The results showed that: the value of a* was the highest in the protein level of 45.90%,but no significant comparing with DL2 and DL3(P0.05).The concentration of carotenoid in the skin of fish was increasing significantiy in the protein level of 30.43(P0.05) while the highest value in the level of 46.90%.The body weight gained and feed conversion ratio were significantly different from DL2 and DL5 at the protein level of 35.04%.The activity of ALT was significantly different from DL1,GLU was significantly different from DL3(P0.05)at the level of 45.90%.And the activity of SOD,CAT hed the highest value at the same level.
Geographical Flushing of the Children’s Face: A New Clinical Entity?

Field: Medicine (Health Sciences)

A lot of skin diseases can occur on children’s faces. We report two children with unique flushing on their faces, sometimes accompanied with headache. Their eruption did not meet various differential diagnoses. Many dermatologists may have seen a similar condition but did not think much about it. Thus, it should be worth regarding such symptom as the benign new clinical entity, which may comfort patients with similar conditions and merit further attention in clinical practice.
Peroral endoscopic dual myotomy (dual POEM) for achalasia with severe esophageal dilatation

Field: Medicine (Health Sciences)

Although the high effectiveness of endoscopic or surgical myotomy for treating achalasia has been well recognized, persistent or recurrent symptoms may develop following the procedure [1] [2]. A review has summarized the negative predictors of myotomy for achalasia patients, which include severe preoperative dysphagia and the presence of an enlarged esophagus [3]. Subsequent reports revealed that repeated myotomy on the same side or the opposite side can be performed with positive outcomes in such patients [1] [4] [5]. Herein, we describe a peroral endoscopic dual myotomy (dual POEM) technique, in which dual myotomies are performed during a single procedure, to avoid repeat intervention for achalasia patients with negative predictors.
Prevention of the Cardiotoxic Effects of Adriamycin and Daunomycin in the Isolated Dog Heart

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

SummaryIn the isolated, blood-perfused dog heart daunomycin (50 mg) or adriamy-cin (50 mg) induced significant increases in coronary perfusion pressure. This effect appeared to be related to the conversion of the parent compounds to aglycone metabolites similar to daunomycinone. Pretreatment of the heart with agents blocking the vasoactive actions of epinephrine, histamine, serotonin or acetylcholine did not prevent the alteration in coronary vascular resistance. In contrast, 100 mg of either EDTA or ICRF 159 prevented the marked increase in perfusion pressure and reduced the formation of aglycone metabolites. Chelation is a common property of the 2 agents suggesting that removal of certain cations may alter metabolism and reduce the toxicity of adriamycin and daunomycin.
Whole-Genome Transcriptional Analysis of Chemolithoautotrophic Thiosulfate Oxidation by Thiobacillus denitrificans Under Aerobic vs. Denitrifying Conditions

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Thiobacillus denitrificans is one of the few known obligate chemolithoautotrophic bacteria capable of energetically coupling thiosulfate oxidation to denitrification as well as aerobic respiration. As very little is known about the differential expression of genes associated with ke chemolithoautotrophic functions (such as sulfur-compound oxidation and CO2 fixation) under aerobic versus denitrifying conditions, we conducted whole-genome, cDNA microarray studies to explore this topic systematically. The microarrays identified 277 genes (approximately ten percent of the genome) as differentially expressed using Robust Multi-array Average statistical analysis and a 2-fold cutoff. Genes upregulated (ca. 6- to 150-fold) under aerobic conditions included a cluster of genes associated with iron acquisition (e.g., siderophore-related genes), a cluster of cytochrome cbb3 oxidase genes, cbbL and cbbS (encoding the large and small subunits of form I ribulose 1,5-bisphosphate carboxylase/oxygenase, or RubisCO), and multiple molecular chaperone genes. Genes upregulated (ca. 4- to 95-fold) under denitrifying conditions included nar, nir, and nor genes (associated respectively with nitrate reductase, nitrite reductase, and nitric oxide reductase, which catalyze successive steps of denitrification), cbbM (encoding form II RubisCO), and genes involved with sulfur-compound oxidation (including two physically separated but highly similar copies of sulfide:quinone oxidoreductase and of dsrC, associated with dissimilatory sulfite reductase). Among genes associated with denitrification, relative expression levels (i.e., degree of upregulation with nitrate) tended to decrease in the order nar &gt; nir &gt; nor &gt; nos. Reverse transcription, quantitative PCR analysis was used to validate these trends.
Effect of the high grain protein gene Gpc-B1 from wild emmer (Triticum dicoccoides) on grain yield and quality in different common wheat backgrounds grown under organic management

Field: Agricultural and Biological Sciences (Life Sciences)

Der biologische Landbau hat viele ökologischen Vorteile, steht jedoch auch vor Herausforderungen wie geringeren Erträgen und geringerer Stickstoffverfügbarkeiten für das Wachstum der Pflanzen. Weizen, ein weltweit wichtiges Grundnahrungsmittel, ist im ökologischen Landbau von entscheidender Bedeutung und in Europa die wichtigste Bio-Ackerkultur in Europa. Die Züchtung von Bio-Weizensorten, die auch bei geringer Stickstoffverfügbarkeit einen hohen Proteingehalt im Korn aufweisen, ist für die Einkommenssicherung der Landwirte entscheidend da der Proteingehalt ausschlaggebend für die Qualitätseinstufung und somit Bezahlung ist. Diese Arbeit hatte zum Ziel den Effekt des Allels Gpc-B1b für hohen Kornproteingehalt aus Wildemmer (Triticum dicoccoides) in Brotweizen zu evaluieren. In mehrortigen Feldversuchen in Deutschland, Österreich, Slowakei, Ungarn, Slowenien und Rumänien wurde die Wirkung des Gpc-B1 QTL in sechs verschiedenen genetische Hintergründen von Brotweizen geprüft. Neben dem Ertrag und dem Proteingehalt wurden auch teigrheologische Untersuchungen und ein Backversuch durchgeführt. Die Ergenisse zeigten eine signifikante Erhöhung des Proteingehaltes durch das funktionelle Gpc-B1b-Allel im genetischen Hintergrund der Sorten 'Explorer', 'McNeal' und 'Spontan'. Der Anstieg betrug in diesen Fällen zwischen 0,7% und 1,2 %. Ein solcher Anstieg reicht oftmals aus um eine Weizenpartie in die nächsthöhere Qualitätsklasse zu heben. Die Variationen bei anderen Qualitätsmerkmalen wie den Teigkneteigenschaften und dem Backvolumen sowie dem Kornertag waren stärker vom genetischen Hintergrund und den Umweltbedingungen beeinflusst als von der An- bzw. Abwesenheit von Gpc-B1b. Durch die Optimierung von Weizensorten mittels markergestützter Selektion, wie in diesem Fall gezeigt, können Sorten entwickelt werden die gezielt an die Bedingungen der biologischen Landwirtschaft angepasst sind und somit einen Beitrag zur Nachhaltigkeit des Anbausystems leisten.
[Detection of inferior myocardial infarction based on densely connected convolutional neural network].

Field: Computer Science (Physical Sciences)

Inferior myocardial infarction is an acute ischemic heart disease with high mortality, which is easy to induce life-threatening complications such as arrhythmia, heart failure and cardiogenic shock. Therefore, it is of great clinical value to carry out accurate and efficient early diagnosis of inferior myocardial infarction. Electrocardiogram is the most sensitive means for early diagnosis of inferior myocardial infarction. This paper proposes a method for detecting inferior myocardial infarction based on densely connected convolutional neural network. The method uses the original electrocardiogram (ECG) signals of serially connected Ⅱ, Ⅲ and aVF leads as the input of the model and extracts the robust features of the ECG signals by using the scale invariance of the convolutional layers. The characteristic transmission of ECG signals is enhanced by the dense connectivity between different layers, so that the network can automatically learn the effective features with strong robustness and high recognition, so as to achieve accurate detection of inferior myocardial infarction. The Physikalisch Technische Bundesanstalt diagnosis public ECG database was used for verification. The accuracy, sensitivity and specificity of the model reached 99.95%, 100% and 99.90%, respectively. The accuracy, sensitivity and specificity of the model are also over 99% even though the noise exists. Based on the results of this study, it is expected that the method can be introduced in the clinical environment to help doctors quickly diagnose inferior myocardial infarction in the future.
The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Questionnaire data capture May-July 2020

Field: Health Professions (Health Sciences)

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 and has followed these women, their partners and their offspring ever since. The study reacted rapidly to the coronavirus disease 2019 (COVID-19) pandemic, deploying an online questionnaire early on during lockdown (from 9th April to 15th May). In late May 2020, a second questionnaire was developed asking about physical and mental health, lifestyle and behaviours, employment and finances. The online questionnaire was deployed across the parent and offspring generations between the 26th May and 5th July 2020. 6482 participants completed the questionnaire (2639 original mothers, 1039 original fathers/partners, 2711 offspring (mean age ~28 years) and 93 partners of offspring). 1039 new participants who did not respond to the first questionnaire deployed in April completed the second questionnaire. A positive COVID-19 was reported by 36 (0.6%) participants (12 G0 and 24 G1), 91 (1.4%; 35 G0 and 56 G1) reported that they had been told by a doctor they likely had COVID-19 and 838 (13%; 422 G0 and 416 G1) suspected that they have had COVID-19. Using algorithmically estimated cases based on symptoms, we estimate that the predicted prevalence of COVID-19 from mid-April to time of questionnaire completion was 3.1%. Data from both COVID questionnaires will be complemented with linkage to health records and results of biological testing as they become available. Data has been released as an update to the original dataset released in May 2020. It comprises: 1) a standard dataset containing all participant responses to both questionnaires with key sociodemographic factors and 2) as a composite release coordinating data from the existing resource, thus enabling bespoke research across all areas supported by the study. This data note describes the second questionnaire and the data obtained from it.
Acute toxicity of the intranasal administration of Anredera cordifolia extract in Wistar Rats

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Anredera cordifolia (AC) known as the binahong plant in Indonesia has been commonly used for traditional medicine since the ancients. AC contains secondary metabolites such as flavonoids that have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Many flavonoids compound that has anti-inflammatory activity have the potential for the treatment of nasal inflammatory such as allergic rhinitis. This study aims to evaluate the preclinical safety of acute intranasal administration of AC extract in Wistar rats with mortality, clinical changes, blood laboratory, and body weight evaluation. Acute toxicity using the intranasal irrigation administration of AC extract was evaluated on 30 female Wistar rats, divided into five rats for control, and each five of doses 5%, 10%, 25%, 50%, and 75%. We perform blood laboratory after administration and observation for 14 days for the incidence of mortality and signs of toxicity such as tremors, hypoactivity, irregular respiration, and bodyweight loss. The AC extract intranasal administration doses at 5, 10, 25, 50, and 75 did not show mortality, or treatment-related adverse events and did not show significantly changes in blood profile. Based on the study the AC extract was found safe until 75% for nasal administration in Wistar rats.
On the Effective Development of Pharmaceutical Service of the Hospital

Field: Health Professions (Health Sciences)

Objective: To investigate the quality and connotation of pharmaceutical service of the hospital and develop it significantly. Methods: The subjects correlated with pharmaceutical service were respectively analysed. Results: Nowadays in our country,whether the pharmaceutical service of the hospital can be effectively developed or not has to depend on hospital controllers and its system but not simply clinical pharmacists. Conclusion: The supporting of more subjects is the basic characteristic of pharmaceutical service of the hospital, which need to greatly co-operate with hospital controllers, staff and pharmacists for the effective development of pharmaceutical service of the hospital.