jimnoneill/paper-to-field-training huggingface dataset:
Evaluation of in vitro bioactivity profile of bee propolis extracts delivered by yeast glucan particles

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Filename: Manuscript.pdfFile Description: This file contains the full version of the manuscript entitled “Evaluation of in vitro bioactivity profile of bee propolis extracts delivered by yeast glucan particles.”File Contents: The document includes the main text, figures, and tables presented in the published article.Filename: Manuscriptdata.xlsxFile Description: This Excel file contains raw data for the results and figures presented in the article: “Evaluation of in vitro bioactivity profile of bee propolis extracts delivered by yeast glucan particles.”File Contents: The workbook includes multiple sheets, each named according to the figures used in the publication.Filename: Supplementaryinformation.pdfFile Description: This file contains supplementary figures, tables, and methodological details supporting the main manuscript “Evaluation of in vitro bioactivity profile of bee propolis extracts delivered by yeast glucan particles.”File Contents: The supplementary document provides additional data, experimental procedures, and supporting discussion referenced in the main article.Filename: Supplementarydata.xlsxFile Description: This Excel file contains raw data used for the results and figures presented in the supplementary data of the article: Evaluation of in vitro bioactivity profile of bee propolis extracts delivered byyeast glucan particlesFile Contents: The workbook includes multiple sheets, each named according to the figures used in the supplementary data of the publication.
Arteriolar rarefaction in murine skeletal muscle linked to shear rate and plasma cytokine dysregulation

Field: Medicine (Health Sciences)

Our purpose was to investigate the effects of leptin deficient type II diabetes on arteriolar network architecture, shear rate (SR) gradients and plasma cytokine levels. Terminal arteriolar networks were observed in the cremaster muscle of age matched C57BL/6 mice (n=34), OB/OB mice (n=6) or DB/DB mice (n=5). Network architecture for sequential branches (B) along the central feed showed robust networks for C57 (472±38um length; 3.5±0.2 B/network; diameter feed 10±0.5um), and rarefaction that was succinctly different for OB/OB vs DB/DB. For OB/OB, density was attenuated with a variable feed (F) length (761±248um) but unchanged #B (3.6 ± 0.3 B/network) and diameter (F 10±1um); for DB/DB, shorter networks (206±31um*) had reduced #B (2±0.7 B/network*) and smaller feed diameter (F 8±1um*). Axial gradients in SR for C57 showed consistency along the feed, with predictable ~1.5‐fold spikes within bifurcations. SR for OB/OB was dysregulated (4‐fold spikes) and overall increase downstream. SR for DB/DB was depressed overall, with an overall decrease downstream. Plasma cytokine levels showed decreased IL3, IL9 and GM‐CSF in each diabetic model vs. C57, while IL6 and VEGF levels were significantly lower in DB/DB, and higher in OB/OB vs. C57. Thus, the changes in architecture and SR profiles are associated with specific changes in proliferative/angiogenic cytokines. *p<0.05 vs. C57. Thanks to NIH DK68401 AHA 0655908T.
STRENGTHENING THE DIMENSIONS OF PANCASILA STUDENT PROFILE IN SCHOOL MOVER IN THE ERA OF INDUSTRIAL REVOLUTION 4.0

Field: Social Sciences (Social Sciences)

The progressive era impacted the decline in the Pancasila values implementation in everyday life. The young generation behaves not according to the values and norms that apply in society. Based on this, it is necessary to strengthen character education in the era of the industrial revolution 4.0. In this era, science and technology developed rapidly. School mover is the school model of Kurikulum Merdeka implementation. One of the messages in the curriculum is strengthening character education. The character education implementation in the Kurikulum Merdeka is based on Pancasila values, called the Pancasila student profile. This research used qualitative methods, especially case studies. The researcher collected data by observation, in-depth interviews, and documentation; he tested the validity of the data by source triangulation and method triangulation. Data analysis included the stages of collecting data, identifying, sorting data, and concluding. Based on the research results, school movers, especially the Persatuan Umat Islam Elementary School, implemented strengthening character education by developing a religious basis, namely Islamic values. Educators trained students to implement the dimensions of the Pancasila student profile with a humanist approach and innovative strategies. They also used technology in various school activities because they educated the millennial generation; this generation is interested in technological developments.
Synthesis, characterization, and property of biodegradable PEG-PCL-PLA terpolymers with miktoarm star and triblock architectures as drug carriers

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

A series of amphiphilic terpolymers with miktoarm star and triblock architectures of poly(ethylene glycol) (PEG), poly(ε-caprolactone) (PCL) and poly(l-lactide acid) (PLLA) or poly(DL-lactide acid) (PDLLA) terpolymers were synthesized as carriers for drug delivery. The architecture, molecular weight and crystallization behavior of the terpolymers were characterized. Anticancer drug doxorubicin was encapsulated in the micelles to investigate their drug loading properties. The miktoarm star terpolymers exhibited stronger crystallization capability, smaller size and better stability than that of triblock polymeric micelle, owing to the lower CMC values of miktoarm star polymeric micelle. Furthermore, the drug-loaded miktoarm star polymeric micelles showed the cumulative DOX release account of the micelles with PDLLA blocks was 65.3% while the release account of the corresponding micelles containing PLLA blocks was 45.2%. The IC 50 values of drug-loaded miktoarm star polymeric micelle were lower than triblock polymeric micelle. Meanwhile, Confocal laser scanning microscopy (CLSM) and Flow Cytometry results demonstrated that the miktoarm star micelles were more favorable for cellular internalization. The miktoarm star micelles with PDLLA blocks were promising carriers for anticancer drug delivery.
A comparison of linear and nonlinear correlation factors for basis set limit Møller-Plesset second order binding energies and structures of He2, Be2, and Ne2

Field: Chemistry (Physical Sciences)

The basis set limit Møller-Plesset second-order equilibrium bond lengths of He2, Be2, and Ne2, accurate to 0.01a0, are computed to be 5.785a0, 5.11a0, and 6.05a0. The corresponding binding energies are 22.4±0.1, 2180±20, and 86±2μEh, respectively. An accuracy of 95% in the binding energy requires an aug-cc-pV6Z basis or larger for conventional Møller-Plesset theory. This accuracy is obtained using an aug-cc-pV5Z basis if geminal basis functions with a linear correlation factor are included and with an aug-cc-pVQZ basis if the linear correlation factor is replaced by exp(−γr12) with γ=1. The correlation factor r12exp(−γr12) does not perform as well, describing the atom more efficiently than the dimer. The geminal functions supplement the orbital basis in the description of both the short-range correlation, at electron coalescence, and the long-range dispersion correlation and the values of γ that give the best binding energies are smaller than those that are optimum for the atom or the dimer. It is important to sufficiently reduce the error due to the resolution of the identity approximation for the three- and four-electron integrals and we recommend the complementary auxiliary basis set method. The effect of both orbital and geminal basis set superposition error must be considered to obtain accurate binding energies with small orbital basis sets. In this respect, we recommend using exp(−γr12) with localized orbitals and the original orbital-variant formalism.
Clinical Characteristics of Newborns Born to Mothers with COVID-19

Field: Medicine (Health Sciences)

(1) Background: According to the literature, most outcomes of neonates born to mothers infected with SARS-CoV-2 are favorable. This study aimed to assess the clinical characteristics of newborns born to infected women in a tertiary center in Poznan, Poland. (2) Methods: The study comprised 101 newborns delivered by women infected with SARS-CoV-2. The control group consisted of 101 newborns born before the pandemic. Data were collected retrospectively from the medical records. (3) Results: Most newborns of SARS-CoV-2-positive mothers were delivered by cesarean section—83.17% vs. 40.59% in the control group (p < 0.05). The groups did not differ in Apgar scores and the need for resuscitation. Newborns of SARS-CoV-2-positive mothers were more likely to present with respiratory distress and require respiratory support. The most common diagnosis was transient tachypnea of the newborn, not correlated with the mode of delivery. Newborns of the study group were never exclusively breastfed, 0% vs. 64.36% (p < 0.05). None of the patients in the study group was tested positive for the virus. (4) Conclusions: Infants born to SARS-CoV-2-positive mothers seem to be more at risk of moderate respiratory failure than other newborns. Separation of mother–baby dyads results in a dramatic fall in breastfeeding in the short-term post-partum period.
Integrative Spatial and Transcriptomic Profiling of Tumor Immune Interactions in Lung Cancer

Field: Medicine (Health Sciences)

Immune checkpoint inhibitors (ICIs) have reshaped the treatment of non-small cell lung cancer (NSCLC) by harnessing the immune system’s ability to recognize and eliminate tumor cells. While these therapies have led to durable responses in some patients, many fail to benefit, and current biomarkers offer limited prognostic and predictive value. This dissertation leverages advancements in spatial imaging, transcriptomic profiling, and data science to characterize the NSCLC tumor microenvironment and identify spatial and molecular features associated with immune engagement and overall survival. In the first part of this work, I develop and apply a computational pipeline for single-cell analysis of multiplexed immunofluorescence images. This platform enables the quantification of cellular phenotypes, spatial neighborhoods, and tissue architecture, providing a flexible framework for spatial systems immunology. The second part of the dissertation focuses on tumor-intrinsic expression of major histocompatibility complex class II (MHC II) molecules, a pathway with known roles in antigen presentation and immune activation but limited characterization in lung cancer. I integrate multiplexed imaging, spatial transcriptomics, bulk RNA sequencing, and single-cell RNA sequencing to characterize the heterogeneity of MHC II expression in lung adenocarcinoma and assess its relationship with immune microenvironment features, tumor cell states, and patient survival. Together, this body of work advances both computational tools and biological insight into NSCLC immunobiology. It highlights the prognostic relevance of spatially resolved, cell-intrinsic features and offers a framework for future studies aimed at improving patient stratification and informing biomarker development.
Considerations on the Epistemological Approach of Mīrzā Mahdī Iṣfahānī in al-Abwāb al-Hudā

Field: Arts and Humanities (Social Sciences)

Maktab-i Tafkīk (the Separation School) in Imāmīyya Shīʿa insists on the separation of philosophical and mystical beliefs from Islamic teachings. The School is also known as the School of Khurāsān and continues to have a great impact on seminaries in the region. It was established by the Iranian scholar Mīrzā Māhdī Iṣfahānī (1886–1946). One of the most important books of Mīrzā, and indeed the one which is said to have a great role in forming the school, is ʾAbwāb al-Hudā. In this book, Mīrzā introduces a different epistemology against philosophers, which he considers as the miracle of the Qurʾān. “Light” is a key word in this epistemology. Mīrzā’s epistemological theory in Abwāb al-Hudā does not seem to be original in all aspects, though. It is just like a more Shīʿītized version of what already existed. The article discusses Mīrzā’s shining epistemology, and takes a look at some of the earlier similar approaches to the knowledge. All of this should be seen in the context of traditionalists’ attempt to distinguish human knowledge from divine knowledge. There are several editions of Abwāb al-Hudā, of which the edition of Ḥusayn Mufīd (Munīr publication) will be used as the main source in this research.
Ouabain chronic infusion enhances the growth and steroidogenic capacity of rat adrenal zona glomerulosa: The possible involvement of the endothelin system

Field: Medicine (Health Sciences)

Ouabain, an inhibitor of the Na+/K+-ATPase, has been reported to affect the secretory activity of the adrenal cortex, and especially of zona glomerulosa (ZG). However, conflicting results were obtained, depending on the experimental condition used since ouabain appears to interact with angiotensin-II (Ang-II) and its action to be influenced by the electrolyte balance. Hence, we investigated the effects of prolonged (4-month) infusion with ouabain on the rat adrenal cortex. Ouabain raised the plasma concentrations of aldosterone, corticosterone and endothelin-1 (ET-1), without affecting either systolic blood pressure (SBP) or plasma renin activity (PRA). The treatment caused a marked hypertrophy of ZG and ZG cells, which mainly ensued from increases in the volume of the mitochondrial and smooth-endoplasmic-reticulum compartments, where the enzymes of steroid synthesis are located. Conversely, the volume of the lipid-droplet compartment, which stores cholesterol utilized in steroid-hormone production, underwent a striking decrease. Zona fasciculata and its parenchymal cells were not affected. Basal and maximally agonist (ACTH, Ang-II and ET-1)-stimulated in vitro mineralocorticoid secretion from adrenal slices was also notably enhanced by ouabain administration. Collectively, these findings indicate that prolonged treatment with ouabain selectively stimulates the growth and steroidogenic capacity of the rat adrenal ZG. The possibility that the activation of the renin-angiotensin system may be involved in this effect of ouabain is ruled out by the lack of significant changes in SBP and PRA. Instead, our results suggest the possible involvement of ET-1, the plasma level of which is elevated in ouabain-infused rats.
Adaptive detection of signals in impulsive noise environments

Field: Computer Science (Physical Sciences)

A detector structure and an adaptive algorithm are proposed for the reception of signals in noise backgrounds possessing broad-tailed probability distributions typical of impulsive noise. The adaptive detector combines the best features of linear matched filtering and hard-limiting receiver structures resulting in a small-signal SNR performance which is an improvement over either of these detectors alone. Furthermore, the adaptive detector is relatively easy to implement and provides efficient performance regardless of the actual noise distribution.
No Easy Way Out for EZH2: Its Pleiotropic, Noncanonical Effects on Gene Regulation and Cellular Function

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Enhancer of zeste homolog 2 (EZH2) plays critical roles in a range of biological processes including organ development and homeostasis, epigenomic and transcriptomic regulation, gene repression and imprinting, and DNA damage repair. A widely known function of EZH2 is to serve as an enzymatic subunit of Polycomb repressive complex 2 (PRC2) and catalyze trimethylation of histone H3 lysine 27 (H3K27me3) for repressing target gene expression. However, an increasing body of evidence demonstrates that EZH2 has many “non-conventional” functions that go beyond H3K27 methylation as a Polycomb factor. First, EZH2 can methylate a number of nonhistone proteins, thereby regulating cellular processes in an H3K27me3-independent fashion. Furthermore, EZH2 relies on both methyltransferase-dependent and methyltransferase-independent mechanisms for modulating gene-expression programs and/or epigenomic patterns of cells. Importantly, independent of PRC2, EZH2 also forms physical interactions with a number of DNA-binding factors and transcriptional coactivators to context-dependently influence gene expression. The purpose of this review is to detail the complex, noncanonical roles of EZH2, which are generally less appreciated in gene and (epi)genome regulation. Because EZH2 deregulation is prevalent in human diseases such as cancer, there is increased dependency on its noncanonical function, which shall have important implications in developing more effective therapeutics.
Genetic algorithm-based MMSE receiver for MC-CDMA systems transmitting over time-varying mobile channels

Field: Computer Science (Physical Sciences)

A novel multi-user detector, based on a genetic algorithm-assisted per-carrier MMSE criterion, is proposed for MC-CDMA systems transmitting over time-varying multipath fading channels. The analysed multi-user detector outperforms state-of-the-art adaptive receivers based on deterministic gradient algorithms, particularly for an increasing number of users.
[Status of scalp hair and therapy of alopecia in men in Switzerland].

Field: Medicine (Health Sciences)

A community-based interview and a questionnaire of men visiting the dermatologist for treatment of hair loss were conducted in Switzerland, to characterize the significance of scalp hair and self-perception of hair loss in Swiss men, and to evaluate current treatment of hair loss. 508 men, aged 15-74 years, regardless of the degree of hair loss, were interviewed by telephone, and 308 patient questionnaires were completed by 19 dermatologists. The questions addressed by the interview were: degree of self-rated hair loss, time invested for hair care, use or reasons for rejecting hair growing agents, relevant criteria for scalp hair, self-assessment with respect to different "hair communication types". The questionnaire analysed the causes of hair loss, prior and current treatment modalities, and follow-up at the dermatologist. Respondents rated their hair loss on a 5-point, textual scale that ranged from 'no hair loss' to 'bald areas'. 43% reported hair loss to some extent. For 42% a full head of hair was very important, especially for men under 29 years, who invested more time for hair care and had not lost hair. Of men with hair loss, 26% previously applied hair growing agents. Of men consulting the dermatologist for hair loss, 90% had androgenetic alopecia. 37% were previously treated: prior treatment was in 59% minoxidil, in 4% finasteride (Propecia), in 7% Aminexil, in 7% dietary supplements, and in 6% conducted by the hair dresser. In 79% treatment was switched to Propecia: of these, 73% adhered to the follow-up consultations at the dermatologist.
Study of free convection along a heated vertical cylinder using numerical and analytical methods

Field: Engineering (Physical Sciences)

Over the past few decades, there has been numerous and extensive studies conducted on free convection along cylinders. Free convection is commonly studied around cylindrical objects as they are the ones that are normally encountered in real-life engineering applications such as pipes, coils and wires, just to name a few. Some of the surface heating conditions that were employed in these studies were the uniform wall temperature, the variable wall temperature, the constant wall heat flux and the variable wall heat flux. Moreover, these studies mainly employed either numerical or experimental methods for their analysis. Hence, this study conducted by the author focused on the free convection along a heated vertical cylinder, applying both numerical and analytical methods. The surface heating condition used was the variable wall temperature. Following an extensive literature review on convective heat transfer, the free convection along a heated vertical cylinder problem was defined. Following that, a mathematical formulation was conducted for the problem. Next, the velocity profile, temperature profile, skin friction coefficient profile and the heat transfer rate profile graphs were plotted (as ξ,n and Pr values were varied), using the “Maple” software. In general, the skin friction coefficient drops while the heat transfer rate rises as n and Pr was increased. However, an anomaly was observed for the case of n = 2. Following this, a perturbation technique was employed to detemine the analytical solutions. These solutions was applied to determine the skin friction coefficient values and heat transfer rate values. However, these analytical solutions were only applicable for either small (ξ < 1) or very large values of ξ. Nonetheless, it was determined that the analytical solutions obtained had a high degree of accuracy (percentage errors of less than 5% was obtained). This author’s main aim, which was to study the free convection along a heated vertical cylinder using numerical and analytical solutions, was achieved. The insights from these results can serve as a comparison with previous research and can be applied to simulate natural convection heat transfer for other object geometries, orientations and surface heating conditions.
Investors' behaviour in the Athens Stock Exchange (ASE)

Field: Economics, Econometrics and Finance (Social Sciences)

Purpose The purpose of this paper is to investigate the various methods and techniques used by Greek investors (both professional and individuals) when evaluating potential additions to their investment portfolios. Design/methodology/approach The paper uses both a questionnaire survey and a series of interviews to examine the practice of investment management in terms of stock market forecasting and stock valuation. The respondents consist of six different groups of investors, drawn from across Greece, namely: official members of the Athens Stock Exchange, mutual fund management companies, portfolio investment companies, listed companies, brokers and individual investors (ININ). Findings The results indicate that ININ rely more on newspapers/media and noise in the market when making their investment decisions, while professional investors rely more on fundamental and technical analysis and less on portfolio analysis. The investment horizon seems to have a direct association with the relative importance of the techniques that professionals use for stock analysis. Also, the use of specific techniques seems to have a different impact on the performance of professionals. Practical implications The results highlight the practical methods and techniques used by various Greek investors when making their stock investment decisions as well as analysing the consequences of these methods on their performance. Originality/value This paper is the first study of the methods used by different classes of investor in the relatively underdeveloped capital market of Greece.