jimnoneill/paper-to-field-training huggingface dataset:
Enhanced bioavailability of oxolinic acid by ultra-fine size reduction in yellowtail.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Effects of ultra-fine size reduction of oxolinic acid on the absorprion by yellowtail were studied by a high performance liquid chromatographic method. Under the high performance liquid chromatographic conditions using a fluorescent detector set for the determination of oxolinic acid in yellowtail tissues, oxolinic acid was well separated from the endogenous com-ponents of yellowtail and the limits of detection in the serum, liver, kidney and muscle were 0.01-0.03 μg/ml or g. After oral administration of the ultra-fine size oxolinic acid in a diet at 30mg/kg once a day for 5 days, the concentration of oxolinic acid in yellowtail tissues went below the limit of detection (0'01-0.03μg/ml or g) within 3 days in the serum, 10days in the liver, 16days in the kidney and 13days in the muscle. When pharmacokinetic parameters were compared between the ultra-fine (diameter=1.0μm) size and ordinary (diameter=6.4μm) preparation of oxolinic acid after single oral administration at 30mg/kg, these two types of oxolinic acid were almost equal in the time of peak serum concentrations, but the peak concentration and areas under the serum concentration-time curve of the ultra-fine size type was 1.7 and 1.3times higher than those of the ordinary type, respectively. Thus, the bioavailablity of oxolinic acid was enhanced by particle size reduction.
Cortical neuronal morphology and MR spectroscopy in Walker-Warburg syndrome caused by novel POMT1 mutation

Field: Medicine (Health Sciences)

Walker-Warburg syndrome is an autosomal recessive disease, belonging to the group of congenital muscular dystrophies. Clinically, main characteristics are congenital brain and occular abnormalities and muscular dystrophy. The syndrome is genetically heterogenous, with mutations found so far in five different genes. We report new nauropathological and neuroradiological changes in an infant with WWS and novel genotype.
A rare case of thrombocytopenia secondary to taking febuxostat

Field: Medicine (Health Sciences)

A new and powerful selective xanthine oxidase inhibitor called febuxostat seems to be well tolerated by all patient populations, even those who are allopurinol-sensitive. Thrombocytopenia is an extremely uncommon side effect. The case of a 63- year-old man who presented with sudden thrombocytopenia and was ultimately linked to febuxostat consumption is described below. The case happened in our department.
A Rapid Method for Identifying Plant Oxidative Stress and Implications for Riparian Vegetation Management

Field: Environmental Science (Physical Sciences)

Native and invasive plants of the riverain region undergo a range of environmental stresses that result in excess reactive oxygen species (ROS). Hydrogen peroxide (H2O2) is a relatively stable and quickly quantifiable way among different ROS. The herbaceous species including Artemisia princeps, Sicyos angulatus, and Solidago altissima were selected. The H2O2 and photosynthetic pigment of leaves were measured, soil samples were analyzed to quantify macronutrients such as total nitrogen (TN), total phosphorus (TP), and soil moisture, and photosynthetic photon flux density (PPFD) was also recorded at different observed sites of Arakawa Tarouemon, Japan. The H2O2 concentration of S. altissima significantly increased with high soil moisture content, whereas A. Princeps and S. angulatus significantly decreased with high soil moisture. In each species, H2O2 was negatively correlated with chlorophyll a (chl a) and chlorophyll b (chl a). When comparing different parameters involving TN, TP, PPFD, and soil moisture content with H2O2 utilizing the general additive model (GAM), only soil moisture content is significantly correlated with H2O2. Hence, this study suggests that H2O2 would be an effective biomarker for quantifying environmental stress within a short time, which can be applied for riparian native and invasive plant species vegetation regulation.
Sustained response to bevacizumab in a patient with mosaic neurofibromatosis type 2 carrying the NF2:c.784C>T p.(Arg262*) variant

Field: Medicine (Health Sciences)

Neurofibromatosis type 2 (NF2) is a tumor predisposition syndrome characterized by the growth of schwannomas, especially bilateral vestibular schwannomas (VS), meningiomas, and ependymomas. The anti-VEGF antibody bevacizumab has shown efficacy for VS in some NF2 patients. However, there is limited data on the effect of bevacizumab on non-vestibular tumors, and on the correlation between therapy response and genotype. Here, we report on a 33-year-old patient with bilateral VS, 14 additional intracranial or spinal schwannomas, and a meningioma treated with bevacizumab, off-label in the European Union, for 2 years. The genotype of the patient was determined by mutational analysis of NF2, SMARCB1, and LZTR1 on DNA of multiple tissues. Additionally, we performed volumetric measurements of quantifiable non-vestibular tumors (n = 8) on MRI scans from 5 pre-therapeutic and 2 therapeutic years, and pure-tone audiometry of the non-deaf ear. A heterozygous NM_000268.3(NF2):c.784C>T p.(Arg262*) variant was identified in DNA from 3 schwannomas, but not in leukocyte or oral mucosa DNA, and no rare SMARCB1/LZTR1 variants were detected, establishing the diagnosis of definite NF2 mosaicism. While schwannomas had progressed with a mean annual growth rate of 38% pre-therapeutically, volume stabilization or reduction of all schwannomas along with improvement of pain and neurological deficits, including hearing impairment, were observed under 24 months of bevacizumab. In summary, this is the first report of a sustained response to bevacizumab in a patient shown to carry the frequent mosaic NF2:c.784C>T p.(Arg262*) variant. Our results may be of particular relevance to guide treatment decisions in mosaic NF2 patients harboring this variant.
Importance of anisotropy in detachment rates for force production and cargo transport by a team of motor proteins

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Many cellular processes are driven by collective forces generated by a team consisting of multiple molecular motor proteins. One aspect that has received less attention is the detachment rate of molecular motors under mechanical force/load. While detachment rate of kinesin motors measured under backward force increases rapidly for forces beyond stall‐force; this scenario is just reversed for non‐yeast dynein motors where detachment rate from microtubule decreases, exhibiting a catch‐bond type behavior. It has been shown recently that yeast dynein responds anisotropically to applied load, i.e. detachment rates are different under forward and backward pulling. Here, we use computational modeling to show that these anisotropic detachment rates might help yeast dynein motors to improve their collective force generation in the absence of catch‐bond behavior. We further show that the travel distance of cargos would be longer if detachment rates are anisotropic. Our results suggest that anisotropic detachment rates could be an alternative strategy for motors to improve the transport properties and force production by the team.
Al Safat Hayam – On the Banks of the Sea: The Ebb and Flow of Life

Field: Arts and Humanities (Social Sciences)

Individuation and integration of parts of the Self can present as a delicate dance between emerging internal images and contact with the external world. The in-between place between the banks and the waters is a symbolic space that speaks of this energy, sometimes delicate and sometimes fiercely powerful. This article focuses on the power of the banks vis-a-vis Jewish sources on water, and other Jewish stories, including the ebb and flow of life that occurs on the banks of the sea as Moshe leads the Jewish nation from slavery to freedom. Three clinical examples of sandplay with images of water and the banks are presented.
Modal Policy Management Framework for Management of Distributed Systems

Field: Computer Science (Physical Sciences)

Policy-based management has emerged as a promising solution for the management of large-scale and heterogeneous networks, since it can reduce complexity in management applications. Meanwhile, one of the key challenges is to may require adaptation of existing policies to dynamic and distributed circumstances. Thus, policies themselves need to be managed and adapted. Modal policy management framework (MPMF) is proposed to supports collaborative management operations and dynamic adaptation of policy in response to changes within the managed environment. A large scale distributed management system is divided into many management domains to autonomous management. Global state view is acquired through resource pool and the corresponding triggering update mechanism. A modal logic-based policy definition language and its syntax are defined, which can be used to describe system's goal and decision functions. Finally, the monitoring and management model is presented to show that MPMF can meet the requirements of management of distributed systems.
Seduction, Surrender, and Transformation

Field: Psychology (Social Sciences)

Seduction, Surrender, and Transformation demonstrates how interpersonal psychoanalysis obliges analysts to engage their patients with genuine emotional responsiveness, so that not only the patient but the analyst too is open to ongoing transformation through the analytic experience. In so doing, the analyst moves from the position of an "interpreting observer" to that of an "active participant and facilitator" whose affective communications enable the patient to acquire basic self-trust along with self-knowledge. Drawing on the current literature on affect, Maroda argues that psychological change occurs through affect-laden interpersonal processes. Given that most patients in psychotherapy have problems with affect management, the completing of cycles of affective communication between therapist and patient becomes a vitally important aspect of the therapeutic enterprise. Through emotionally open responses to their patients and careful use of patient-prompted self-disclosures, analysts can facilitate affect regulation responsibly and constructively, with the emphasis always remaining on the patients' experience. Moments of mutual surrender - the honest emotional giving over of patient to analyst and analyst to patient - epitomize the emotionally intense interpersonal experiences that lead to enduring intrapsychic change. Maroda's work is profoundly personal. She does not hesitate to share with the reader how her own personality affects her thinking and her work. Indeed, she believes her theoretical and clinical preferences are emblematic of the way in which the analyst's subjectivity necessarily shapes theory choice and practice preferences in general. Seduction, Surrender, and Transfomation is not only a powerful brief for emotional honesty in the analytic relationship but also a model of the personal openness that, according to Maroda, psychoanalysis demands of all its practitioners.
Interference effects for H --> WW --> lvqq and H --> ZZ --> llqq searches in gluon fusion at the LHC

Field: Physics and Astronomy (Physical Sciences)

Signal-background interference effects are studied for H --> WW and H --> ZZ searches in gluon fusion at the LHC. More specifically, the interference in the channels with semileptonic weak boson pair decay is analysed for light and heavy Higgs masses with minimal and realistic experimental selection cuts. In the semileptonic decay modes, the interference is affected by tree-level background contributions enhanced by 1/e^2 relative to the gluon-fusion continuum background in the fully leptonic decay modes. We find that for both light and heavy Higgs masses the interference with the loop-induced weak-boson pair background dominates over the interference with the tree-level weak-boson plus jets background for a range of selection cuts. We therefore conclude that higher-order background contributions can induce leading interference effects. With appropriate background suppression cuts the interference can be reduced to the 10% level for heavy Higgs masses, and to the per mille level for the light SM Higgs.
SH0927361.10FU

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?

Field: Medicine (Health Sciences)

Abstract Background Simultaneous bilateral distal tibial tubercle high tibial osteotomy (SBDTT-HTO) can result in increased blood loss. The aim of this study is to evaluate the actual hemostatic effect of different tranexamic acid (TXA) treatment regimen in SBDTT-HTO. Methods We conducted a retrospective case–control study including 54 patients who underwent SBDTT-HTO. The single-dose group (n = 18) received 1 g of intravenous TXA 15–30 min before surgery, the two-dose group (n = 18) received an additional 1 g of intravenous TXA 6 h after surgery, and the multiple-dose group (n = 18) received an additional 1 g intravenous TXA per-day until discharge. Blood loss, hemoglobin levels, occurrence of any adverse events,functional analysis, quality of life, and pain assessmentswere compared among the three groups. Results The total blood loss, hidden blood loss, drainage volumes, and haemoglobin level in the multiple-dose group all occupy a significant advantage.( p < 0.05). In addition, faster recovery and better quality of life were observed in patients belonging to the multiple-dose group then single-dose group.( p < 0.05). Conclusions Based on our results, for patients undergoing SBDTT-HTO, sequential intravenous TXA administration can effectively and safely reduce blood loss without increasing the risk of thromboembolism, with the advantage of accelerating recovery.
Enzymes and Ionic Liquids: a Promising Combination Towards a Clean Biodiesel

Field: Chemical Engineering (Physical Sciences)

The current manuscript describes the advantages of ionic liquids and lipases (enzymes) association towards a clean biodiesel.Acidic and basic catalytic processes, as their technological drawbacks are discussed herein.The main interaction between such enzymes and ionic liquids are presented for a better understanding of the improvement on the catalytic activity of lipase enzymes when these biocatalysts are supported on an ionic media.Selected examples of recent scientific literature are described to show the promising and powerful combination towards a clean biodiesel synthesis.
Associations of Dietary Patterns and Vitamin D Levels with Iron Status in Pregnant Women: A Cross-Sectional Study in Taiwan

Field: Medicine (Health Sciences)

Vitamin D is involved in the pathophysiology of anemia. This cross-sectional study was conducted using the Nationwide Nutrition and Health Survey in Pregnant Women in Taiwan database. We investigated associations among dietary patterns (DPs), vitamin D, and iron-related biomarkers in pregnant women. The principal component analysis revealed four DPs. Linear and logistic regression analyses were performed to investigate the association of DPs with anemia-related biomarkers. Plant-based, carnivore, and dairy and nondairy alternatives DPs were positively associated with serum vitamin D levels. After adjusting covariates, the pregnant women consuming plant-based DPs at the mid-tertile (T2) were associated with reduced risks of low serum folate and vitamin D levels, and those consuming carnivore DPs at higher tertiles (T2 and/or T3) were correlated with an increased risk of low serum iron levels but decreased risks of low serum transferrin saturation, vitamin B12, and vitamin D levels. The pregnant women consuming dairy and nondairy alternatives DPs at the highest tertile (T3) were associated with reduced risks of low serum folate and vitamin B12 levels. However, the processed food DP was not correlated with anemia-related biomarkers. Thus, plant-based, carnivore, and dairy and nondairy alternatives DPs were associated with the risk of low-serum-anemia-related variables.
Erosion and Sedimentation. By Henri and Genevieve Termier (translated by D. W. and E. Humphries). D. van Nostrand and Co., London. xii + 433 pages, 206 figs., glossary. Price 70s.

Field: Earth and Planetary Sciences (Physical Sciences)

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Effect of Acid-Base Pretreatment on Reducing Sugar Production by Wild Glutinous Rice

Field: Agricultural and Biological Sciences (Life Sciences)

As a lignocellulosic biomass, wild colocasia can be efficiently hydrolyzed into reducing sugar after a certain degree of pretreatment. It is a high-quality raw material for the development and utilization of biomass energy such as fuel ethanol. The three factors of concentration, temperature, time, and solid-liquid ratio were selected as the three-level orthogonal experiment. The effects of acid-base pretreatment on the reduction of sugar in the wild carp were studied. The cell wall of the wild carp was treated by electron microscopy before and after pretreatment. The change. The experimental results show that the cell wall of the wild colocasia is thinner, the pores become larger, and the contact area is increased. The effect of acid pretreatment on the reduction of sugar by the wild colocasia is better than that of alkali pretreatment. When the acid concentration is 0.5% and the temperature is 100°C and solid-liquid ratio is 1:40, and the treatment time is 90min, the concentration of reducing sugar produced is up to 67.32mg/g.
The effect of di-(-2-ethyl hexyl) phthalate (Dehp) as plasticizer on the thermal and mechanical properties of pvc/pmma blends

Field: Materials Science (Physical Sciences)

Plasticizers play a key role in the formulation of polymers and in determining their physical properties and processability. This study examines the effect of di(2-ethyl hexyl)phthalate (DEHP) as plasticizer on the thermal and mechanical properties of PVC/PMMA blends. For that purpose, blends of variable composition, from 0 to 100 wt%, were prepared in the presence (15, 30 and 50 wt %) and in the absence of di(2-ethyl hexyl)phthalate. The thermal degradation of the blends was investigated by thermogravimetric analysis (TGA) in an atmosphere of synthetic air in the temperature range of 50-550°C. The variation of the mechanical properties, such as tensile behavior, hardness and impact resistance, were investigated for all blend compositions. The effect of the plasticizer on the same properties was considered. The results obtained show that a range of properties can be generated according to the blend compositions. Therefore, the addition of PMMA to the blends stabilized PVC, for the initial thermal degradation, and the addition of the plasticizer caused a decrease of stress at break and Young modulus.
Principal, board member, and staff perceptions of female public school superintendents instructional leadership

Field: Social Sciences (Social Sciences)

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] This study examined the instructional leadership of female superintendents as perceived by board members, principals and staff members who work directly with the participating superintendents. A qualitative, multi-case study provided opportunity to determine the instructional leadership practices as viewed through the lens of instructional leadership research by Waters and Marzano (2006). Four overarching themes emerged: Professional development, focus of resources toward instruction, comprehensive knowledge of quality instruction, collaboration and communication. Findings indicated that the participating superintendent's practices were aligned to findings within current research. The instructional leadership characteristics identified within this study will serve as a model for superintendents and in establishing competencies for professional development activities surrounding instructional leadership.
Protection Against Over-Load and Over-Aligned Issues in LCC-S Compensated Inductive Power Transfer System

Field: Engineering (Physical Sciences)

This paper presents a passive control method utilizing an auxiliary protection circuit for LCC-S compensated converters. The proposed method effectively addresses the challenges of over-load and over-aligned conditions, which can cause excessive inverter output current and higher-than-required system output voltage. By incorporating the auxiliary protection circuit, complex compensated circuits and wireless communication are eliminated, providing a simple and reliable solution. Experimental validation was performed in a 48 V wireless charging prototype to demonstrate the efficacy of the protection strategy in promptly safeguarding the primary circuit against device damage.
STGAN: Spatio-Temporal Generative Adversarial Network for Traffic Data Imputation

Field: Computer Science (Physical Sciences)

The traffic data corrupted by noise and missing entries often lead to the poor performance of Intelligent Transportation Systems (ITS), such as the bad congestion prediction and route guidance. How to efficiently impute the traffic data is an urgent problem. As a classic deep learning method, Generative Adversarial Network (GAN) achieves remarkable success in image recovery fields, which opens up a new way for the traffic data imputation. In this paper, we propose a novel spatio-temporal GAN model for the traffic data imputation (STGAN). Firstly, we design the generative loss and center loss, which not only minimizes the reconstructed errors of the imputed entries, but also ensures each imputed entry and its neighbors conform to the local spatio-temporal distribution. Then, the discriminator uses the convolution neural network classifier to judge whether the imputed matrix conforms to the global spatio-temporal distribution. As for the network architecture of the generator, we introduce the skip-connection to keep all well preserved data unchanged, and employ the dilated convolution to capture the spatio-temporal correlation in the traffic data. The experimental results show that our proposed method obviously outperforms other competitive traffic data imputation methods.