jimnoneill/paper-to-field-training huggingface dataset:
A phase Ib dose escalation study of vantictumab (VAN) in combination with nab-paclitaxel (Nab-P) and gemcitabine (G) in patients with previously untreated stage IV pancreatic cancer.

Field: Medicine (Health Sciences)

249 Background: Vantictumab is a fully human monoclonal antibody that inhibits Wnt pathway signaling through binding FZD1, 2, 5, 7, and 8 receptors. A phase Ib study of VAN in combination with Nab-P and G was performed in patients with untreated stage IV pancreatic adenocarcinoma. Methods: Patients received VAN at escalating doses (3-7 mg/kg) in combination with standard dosing of Nab-P and G according to a 3+3 design. Due to fragility fractures occurring in this and other related clinical trials, dosing on an every 2 week schedule in cohorts 1 and 2 was transitioned to every 4 week dosing for cohorts 3 through 5. In these later cohorts, a minimum of six patients were treated at each dose level and additional criteria for maximum tolerated dose (MTD) integrating bone safety parameters were added. The bone safety plan was also revised for these cohorts. Sequential dosing of VAN followed by Nab-P and G was explored in cohort 5. Results: Thirty-one patients (52% male, 48% female) were enrolled and treated in 5 dosing cohorts. Median age was 66. Most common study-treatment related adverse events were nausea (68%) and fatigue (52%). One dose limiting toxicity (DLT) event occurred in the study population—grade 3 dehydration in 1 of 9 patients in cohort 4 (5 mg/kg q4w). Fragility fractures attributed to VAN occurred in two patients in cohort 2 (7 mg/kg q2w). Once the dosing schedule was revised to every 4 weeks, the maximum administered VAN dose was 5 mg/kg. No fragility fractures attributed to VAN occurred in these cohorts; pathologic fracture not attributed to VAN was documented in 2 patients. The study was terminated due to lack of an acceptable therapeutic index. Partial response was documented in 13 patients (42%) and stable disease in 11 (36%). Conclusions: The MTD of VAN plus Nab-P and G was not determined, but the maximum administered dose (MAD) of VAN, 7 mg/kg every 2 weeks, was considered unsafe related to bone toxicity, a known effect of WNT inhibition. After the study was revised, the MAD was 5 mg/kg every 4 weeks, with no protocol-specified bone toxicity observed (n = 16). Clinical trial information: NCT02005315.
Validation of the Calcineurin Phosphatase Assay

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Background: The calcineurin inhibitors cyclosporine and tacrolimus are used as primary immunosuppressive drugs in transplant patients. Measuring calcineurin phosphatase (CaN) activity is a proposed pharmacodynamic approach to optimize dosing of these drugs. Methods: Whole blood samples were obtained from 10 patients treated with calcineurin inhibitors and 20 healthy volunteers and frozen at −80 °C. CaN activity was measured by its ability to dephosphorylate a 19-amino acid peptide previously phosphorylated with [γ-32P]ATP. Radioactivity was quantified by liquid scintillation, and results were converted from cpm to U of CaN. Validation of the assay included enzyme kinetics, linearity, precision (at low and normal CaN activities), analytical recovery, and limit of detection. Results: The enzyme followed simple Michaelis-Menten-type kinetics: Vmax was estimated as 240 nmol 32P · L−1 · min−1 and Km as 70 μmol/L. The assay was linear within the concentration range examined. Analytical recovery varied from 68% to 72%. The total analytical SD was 0.059 and 0.053 U of CaN for high and low CaN activity, respectively. The within-day SD for high and low activity was 0.032 and 0.039 U of CaN, respectively. The limit of detection was 0.04 U of CaN, which is far below the values measured in patients treated with CaN inhibitors. Conclusions: In addition to the pharmacokinetic monitoring applied today, the CaN assay can be used to monitor patients treated with calcineurin inhibitors, hopefully leading to prolonged graft survival.
A Novel Ensemble based Model for Intrusion Detection System

Field: Computer Science (Physical Sciences)

In the present interconnected world, the increasing reliance on computer networks has made them susceptible to multiple security threats and intrusions. Intrusion Detection Systems (IDS) is essential for shielding these networks by detecting and mitigating potential threats in real-time. This research paper presents an in-depth study of employing the Random Forest algorithm for building an effective intrusion detection System. The proposed IDS uses the power of the Random Forest algorithm, a popular ensemble learning technique, to detect various types of intrusions in network traffic effectively. The algorithm integrates more than one decision trees to produce a robust and accurate classifier, capable of handling large-scale and complex datasets typical of network traffic. The proposed system can be used in various industries and sectors to protect critical assets, ensuring the uninterrupted operation of computer networks. Evolving cyber threats have encouraged further research into ensemble analytics methods to increase the resilience of Intrusion Detection Systems in an ever-changing threat landscape.
Research needed on oil palm diseases in Latin America

Field: Agricultural and Biological Sciences (Life Sciences)

The recent appearance of wilt in Brazil brings the number of diseases likely to have an economic impact on oil palm plantations in Latin America to five, the others being: Marchitez, ringspot disease; bud rot and red ring disease. The occasional studies made of these diseases have made it possible to improve our knowledge of them to varying degrees. Although the pathogens and vectors of red ring disease and Marchitez are known, they have yet to be found for bud rot and ringspot disease. Control methods are currently limited to the eradication of diseased trees and empirical treatment with highly remanent insecticides having long residual effect. Research should be intensified in the following areas: test a range of hybrid planting material intra- or inter specific) with a view to identifying genetic characters of resistance; determine the biology of the Marachitez vector (Lincus); define methods of controlling known vectors (insecticides, pheromones, biological control); identify bud rot and ringspot disease pathogens and vectors. Genetic research should be given priority because, although it proves effective, it takes a long time to obtain results.
Effect of NSAIDs on Pupil Diameter and Expression of Aqueous Humor Cytokines in FLACS Versus Conventional Phacoemulsification

Field: Medicine (Health Sciences)

PURPOSE: To compare the concentrations of interleukin (IL) (IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70), interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and TNF-β in the aqueous humor of patients undergoing femtosecond laser–assisted cataract surgery (FLACS) and corneal mechanical paracentesis treated with two different topical nonsteroidal anti-inflammatory drugs (NSAIDs): bromfenac and indomethacin. METHODS: In this prospective, randomized controlled, single-center study, aqueous humor samples were obtained immediately after performing the femtosecond laser procedure or at the start of conventional phacoemulsification. Preoperatively, the FLACS groups were administered (once daily and four times daily, respectively) either topical bromfenac 0.09% (12 eyes) or indomethacin 0.1% (12 eyes). The corneal paracentesis bromfenac and indomethacin groups received the same regimen of instillation of NSAIDs, respectively. Quantitative analysis of the expressed cytokines in the aqueous humor was performed using FlowCytomix FC 500 Pro 3.0 Software (Bender MedSystems GmbH, Vienna, Austria). RESULTS: The intraoperative pupil diameter was correlated with the expression of IL-6 after the femtosecond laser procedure in the FLACS indomethacin group (r = −0.53; P = .07). A significant difference in mean pupillary size was detected between the FLACS bromfenac and indomethacin groups at the aspiration/irrigation time point (0.53 ± 0.26 mm) and at the end of surgery (0.68 ± 0.37 mm). Progressive pupillary constriction was observed in the indomethacin and bromfenac groups. CONCLUSIONS: A smaller expression of IL-6 to the overall cytokine network value was observed in cases receiving preoperative bromfenac 0.09%, explaining improved maintenance of intraoperative mydriasis. [ J Refract Surg. 2018;34(10):646–652.]
Revolutionary women, body, and the limits of nationalist ideology in colonial Bengal: re-reading the memoirs of Bina Das and Kamala Dasgupta

Field: Arts and Humanities (Social Sciences)

This paper deals with the memoirs of two Bengali revolutionary women, Bina Das' Srinkhal Jhankar published in 1948, translated as Bina Das: A Memoir, and Kamala Dasgupta's Rakter Akshare (Written in Blood) in 1954 to argue how their subjective desire and experience dismantle the gendered rhetoric of nationalism in colonial Bengal. The accounts of Bina and Kamala present their involvement in militant activism and subsequent imprisonment. Notably, there is an inherent urge in their writings to sacrifice life for the nation and a determination not to retreat from the torturous conditions of the colonial prison. The paper contends that the rhetoric of nationalism in colonial Bengal is embedded in hegemonic masculinity that initially confined women to the spiritual and domestic realm and later allowed them to be educated and modern without acknowledging their subjectivity. Activities of these political women thus destabilise the gender discourse prevalent in the private and public sphere of colonial society, which calls for a revision of the nationalist historiography. So, this essay will examine how tropes of the body, self-sacrifice, and penal experience, as produced in these memoirs, negotiate the nationalist ideology, subvert the binary of masculine and feminine, and establish their political subjectivity.
Quick Response Code Technology-based Contact Tracing Solutions to Mitigate Epidemic Outbreaks: A Review

Field: Health Professions (Health Sciences)

Several epidemics and pandemics have plagued humanity over the years; however, the coronavirus disease 2019 (COVID-19) pandemic revealed humanity's lack of preparedness for epidemics and pandemic outbreaks. Although several approaches have been proposed, designed, and implemented during and post-COVID-19 by researchers to deal with future epidemic outbreaks, there is a need for lightweight technology solutions to develop technology-based contact tracing (TCT) solutions. Quick response (QR) codes can be considered a lightweight technology as they provide environmentally friendly solutions with flexible applications across industries. They also enable contactless interactions and transactions, which is essential for the health and safety of users in the event of an epidemic. To the best of our knowledge, there exists a few pieces of literature that solely discuss and review the QR code-based TCT solutions adopted during the COVID-19 pandemic. As such, this work explores the QR code for its potential and use as a TCT approach. On this premise, this review discusses factors influencing QR code-based CT and further discusses existing QR code-based techniques for mitigating epidemic outbreaks. Additionally, the hybridization of QR code-based techniques with other TCT solutions has limited discussions that solely focus on QR code-based techniques; as such, QR code-based techniques are compared against other technologies adopted for TCT. The review recommends possible solutions to address the challenges in utilizing QR code-based solutions as it concludes the review.
Mobility as a Service - A Proposal for Action for the Public Administration, Case Helsinki

Field: Social Sciences (Social Sciences)

The passenger transport sector is being affected by several major trends. These trends alter the requirements of the transport system, thus creating a challenge to the city de-velopment. However, it seems that the current organization of the public transport ser-vice provision in Helsinki fails to sufficiently respond to the challenge. Simultaneously, the objective of the national transport policy is to increase the share of sustainable travel modes. In addition to the altering requirements, modern technology, such as means of Intelligent Transport Systems (ITS), provide a spectrum of possibilities in the field. The deployment of ITS could contribute to more efficient utilization of resources, including infrastructure and fleet, improved fluidity of traffic due to real time information, and at-tractive provision of mobility services. \n \nHaving said this, it appears that the passenger transport sector in Helsinki needs to be transformed. In order to discover a possible form and course for the transformation, the Helsinki City Planning Department has procured this study. This study discovers a way to reorganize the passenger transport sector so that it would promote the concept of “Mobility as a Service” (MaaS), that is, convenient provision of a versatility of attractive mobility services. This study provides a suggestion of a transformed mobility sector. Furthermore, it provides a scheduled proposal for action for executing the transfor-mation. \n \nThe study examined former transformations in four industries: telecommunications, en-ergy, airline, and railroad industries. The author aimed to identify the most significant factors that contributed to the success of the transformations. These numerous factors were then formed into proposals for action and crystallized into seven most considerable ones. The seven proposed actions were then appointed to a time scale from 2015 to 2025, thus creating a road map for the transformation of the passenger transport sector in Helsinki. The results show that all stakeholders should cooperate in the transformation, and legislation as well as regulation should be revised. In addition, purchase and subsidization procedures, as well as mobility service provision should be reorganized, and transformed operations established. Additionally, pilots should be conducted from the beginning to gain practical experience.
[Toxicological assessment of a new product from coriander cake].

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Characteristics of the product obtained by the authors from coriander cake, basic results of evaluation of its toxicological properties, basic stages of the experiment on white rats and its results are described. The conclusion about positive influence of the product on metabolism in white rats and perspectives of introduction of the new product from coriander cake as an additive for manufacture of food products is made.
Is Direct Seeding an Alternative to Transplanted Rice Culture and How Transplanted Rice Cultivars Perform under Direct Seeding?

Field: Agricultural and Biological Sciences (Life Sciences)

Field study was made during 2012 kharif season (July- November) at Hyderabad with 12 rice cultivars (6 high yielding varieties; 6 hybrids) belonging to early, mid early and medium duration maturity group (2 varieties / hybrid each) in sub-plots under 3 establishment methods (transplanting, drum seeding and broadcasting) as main plots in split plot design with four replications. Data revealed that direct wet seeding of rice by broadcast on account of 31.7% higher tiller production incurring 9.81% reduction in number of grains/panicle and unaffected test weight of grains has 4.81% higher grain yield than transplanted rice (6.65 t/ha). The reductions in cost of production (Rs. 6975/ha) in broadcast rice owing to 25 man days reduction for transplanting operations coupled with 4.81% higher grain yields together have brought 33.2% higher net profits than transplanted rice (Rs. 32705). Drum seeding on account of reduced cost of production despite of no yield gains, have 24.8% higher net income than transplanted rice. Hybrids on average have 19.4% higher grain yield than the varieties (6.12 t/ha). This yield difference between a hybrid and variety was highest in early (25.2%) followed by mid early (19.1%) and medium maturity group (14.9%). KRH-2 hybrid rice cultivation is most profitable (Rs. 42150) followed by PA 6201 hybrid owing to higher grain yields. Rice cultivar x establishment method indicated that for Sahyadri-4 hybrid, transplanting is better to drum seeding while for Annada, IR-64 and Krishna hamsa varieties and for KRH-2 hybrid; broadcast seeding was promising. Crop duration is reduced by 12-13 days with direct seeding over transplanting. Per day productivity was highest with PA 6201, broadcast sowing.
Effects of managerial ties and trust on supply chain information sharing and supplier opportunism

Field: Business, Management and Accounting (Social Sciences)

Managerial ties and trust are important factors in facilitating collaboration and reducing opportunistic behaviour. There is, however, a lack of empirical evidence on how these relational factors influence the sharing of information among supply chain partners. For example, do stronger managerial ties help to improve supply chain information sharing (SCIS) and reduce supplier opportunism? To what extent SCIS is influenced by managerial ties and trust? How do managerial ties interact with trust in influencing SCIS? Using data from 272 Chinese manufacturers, this paper examines the impact of managerial ties and trust on SCIS and supplier opportunism. The results show that, through trust managerial ties can significantly influence the extent of information sharing and the quality of the information shared. Managerial ties also have a direct impact on the extent of information sharing, but not on the quality of the information shared. The main implication for management practice is that the quality of the information shared – rather than the extent of information sharing – should be seen as the main leverage in reducing supplier opportunism.
Evaluating the Baseline Chatacteristics of Static Balance in Young Adults

Field: Health Professions (Health Sciences)

The objectives of this study (baseline study, n = 20) were to implement Matlab procedures for quantifying selected static balance variables, establish baseline data of selected variables which characterize static balance activities in a population of healthy young adult males, and to examine any trial effects on these variables. The results indicated that the implementation of Matlab procedures for quantifying selected static balance variables was practical and enabled baseline data to be established for selected variables. There was no significant trial effect. Recommendations were made for suitable tests to be used in later studies. Specifically it was found that one foot-tiptoes tests either in static balance is too challenging for most participants in normal circumstances. A one foot-flat eyes open test was considered to be representative and challenging for static balance.
Queer Appearances: Gilbert & George's Visual Strategies

Field: Arts and Humanities (Social Sciences)

The use that visual artists have made of popular media, such as television, has provided a point of critical interest over recent decades. Contemporary artists, Gilbert & George, followed the pace set by media-savvy artists, through their recent television appearance on the popular talk-show Friday Night with Jonathan Ross. Their appearance on prime-time TV raised a series of questions concerning gay visibility, mainstream media and the visual subterfuge deployed in contemporary art. This article seeks to examine such issues against the background of political struggles over public and private space.
Particle Multimodality Monitoring and Hemodynamics

Field: Medicine (Health Sciences)

Hemodynamic optimization is key to resuscitation of critically ill patients in intensive medicine. Delayed or improper treatment will inevitably lead to hypoperfusion, tissue hypoxia and multiple organ failure, which affects the patients' outcome. Therefore, early identification of patients at risk and implementation of adequate monitoring and guidance intervention have a profound impact on the results. The key principle of hemodynamic management is to optimize blood flow and oxygen flow according to current tissue metabolism. To achieve this goal, we need to monitor and get blood pressure, cardiac output, organ-specific automatic regulation and tissue microcirculation. However, the clinical monitoring data is huge. At the same time nearly one hundred pieces of data objectively present the pathophysiological state of the patient, and the changes of data at different time periods can describe the progress of the patients' condition. Therefore, the integrated analysis of time/ frequency domain based on millisecond-level high-resolution data will promote the understanding and practice of hemodynamics at microcosmic level, and help to facilitate clearer judgment and more precise treatment of patients' condition.
Epidemiological and Anatomo Path Ological Aspects of Stomach Cancers at the Koutiala District Hospital

Field: Medicine (Health Sciences)

Aim: This paper aims to evaluate the epidemiological and pathological aspects of stomach cancer at Koutiala District Hospital. Methods: This was a retrospective study carried out in the General Surgery Department of the Koutiala District Hospital Health Centre. The records of patients admitted for stomach cancer in the period from August 1, 2017 to December 31, 2022 were collected. Patients who underwent surgery for stomach cancer were included in the study. Patients who had not undergone surgery were excluded. Results: We collected records from 40 patients operated on for stomach cancer. The median age was 58.4 years ± 5.7. Men were in the majority with 72.5% The sex ratio was 2.6. The incidence rate of stomach cancer in the general population in the circle was 4.9 cases per 100,000 population. Patients had a history of gastric ulcer in 90%, Helicobacter pylori infection in 47.5% and a notion of excessive salt consumption in 47.5%. The median duration of disease progression was 5 years ± 2.3. The seat was antro-pyloric in 77.5%. The cancer was ulcerative budding in 23 patients. Adenocarcinoma was the histological type in all patients. The cancer was classified as stage III in 30 cases and stage IV in 10 cases. Palliative surgical treatment was the most performed (47.5%). Postoperative morbidity was 15% and mortality was 42.5% at one year. Conclusion: Stomach cancer is common in the ward. Most patients consult at the stage of metastasis. Palliative surgery remains the most practical. Postoperative morbidity and mortality is very high.