jimnoneill/paper-to-field-training huggingface dataset:
A GROBA CTERIUM-MEDIA TED TRANSFORMATION OF CANOLA

Field: Agricultural and Biological Sciences (Life Sciences)

Cano1a (Brassica napus L.) is an important oil crop, ranking third only to soybean and palm oil in global production. It is a member of the family Brassicacea (syn. Cruciferae). It is a winter or spring crop and is amenable to growth in cooler climates. Once considered a specialty crop for Canada, it is now a global crop. Many other countries including the USA, Australia and those in Europe also grow cano1a. However, Canada and the United States account for most of the cano1a crop. It is grown mostly in Western Canada and North Central United States. In the year 2002, in Canada alone, 9.6 million acres of cano1a was grown (1) and in the USA, 1.5 million acres was devoted to cano1a cultivation (2). The term 'cano1a' was adopted by Canada apparently as an acronym of the Canadian Oilseed Association in 1979. Although cano1a has been commonly also known as rapeseed or oilseed rape, in the strict sense cano1a oil is defined as an oil that must contain less than 2% erucic acid, and the solid component of the seed must contain less than 30 ~M of anyone or a mixture of 3-buteny1 glucosino1ate, 4-penteny1 glucosino1ate, 2-hydroxy-3 buteny1 glucosino1ate, and 2-hydroxy-4-penteny1 glucosino1ate per gram of air-dry, oil-free solid. Cano1a oil is widely used as cooking oil, salad oil, and making margarine. Of all edible vegetable oils widely available today, it has the lowest saturated fat content, making it appealing to health-conscious consumers. Cano1a oil is also used in lubricants and hydraulic fluids especially when there is a significant risk of oil leaking to waterways or into ground water (3). It is also used in the manufacture of inks, biodegradable grease, in pharmaceuticals and cosmetics. Cano1a meal, which is the leftover product of the seeds after extracting oil, is used as a protein supplement in dairy, beef, swine and poultry rations and is recognized for its consistent high quality and value. The increased processing activity within Canada has led to rising consumption and exports of meal and product mixtures. Feed mixtures include such items as pea-can meal (combining dry peas and cano1a meal) as well as incorporating cano1a meal with dehydrated alfalfa products. The bulk of Canada's cano1a meal exports supply the USA feed ingredient market, which imports over a million t9nnes annually and represents 80% or more of
Exploring the Mechanisms of n-Butanol Extract from Tibetan Medicine Biebersteinia heterostemon in Improving Type 2 Diabetes Based on Network Pharmacology and Cellular Experiments

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

An integrative approach combining network pharmacology, molecular docking, and cellular assays was used to elucidate the potential mechanisms by which the n-butanol extract of Biebersteinia heterostemon ameliorates type 2 diabetes mellitus (T2DM). Chemical constituents of the n-butanol extract were identified via ultra-high-performance liquid chromatography coupled with Q-Exactive Orbitrap mass spectrometry. Active compounds and T2DM-related targets were retrieved from public databases, and intersecting targets were identified. Protein–protein interaction (PPI) networks were constructed using the STRING database, while Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed via the DAVID database. A comprehensive “drug–compound–target–disease–pathway” network was established, and molecular docking was conducted to evaluate binding affinities of key compounds to core targets. Functional validation was performed in insulin-resistant cell models. Network pharmacology analysis identified 37 active constituents within the extract and 222 overlapping targets associated with T2DM. GO enrichment indicated involvement in protein phosphorylation, MAPK cascade activation, and negative regulation of apoptosis. Key signaling pathways included PI3K/AKT and lipid and atherosclerosis pathways. Molecular docking revealed strong binding affinities (binding energies ≤ −9.3 kcal·mol−1) between core compounds—such as cheilanthifoline, glabridin, acetylcorynoline, skullcapflavone II, liquiritigenin, and dinatin—and pivotal targets including GAPDH, AKT1, TNF, SRC, EGFR, and PPARγ. In vitro experiments demonstrated that the extract significantly enhanced glucose uptake and glycogen synthesis in insulin-resistant cells, while suppressing oxidative stress and the expression of pro-inflammatory mediators such as TNF-α, MMP9, and IL-6. Collectively, B. heterostemon shows potential as an effective intervention for T2DM by targeting key molecular pathways, improving insulin sensitivity, and mitigating oxidative stress and inflammation in insulin-resistant cells.
Response of Fractional Oscillators With Viscoelastic Term Under Random Excitation

Field: Mathematics (Physical Sciences)

A system with fractional damping and a viscoelastic term subject to narrow-band noise is considered in this paper. Based on the revisit of the Lindstedt–Poincaré (LP) and multiple scales method, we present a new procedure to obtain the second-order approximate analytical solution, and then the frequency–amplitude response equations in the deterministic case and the first- and second-order steady-state moments in the stochastic case are derived theoretically. Numerical simulation is applied to verify the effectiveness of the proposed method, which shows good agreement with the analytical results. Specially, we find that the new method is valid for strongly nonlinear systems. In addition, the influences of fractional order and the viscoelastic parameter on the system are explored, and the results indicate that the steady-state amplitude will increase at a fixed point with the increase of fractional order or viscoelastic parameter. At last, stochastic jump is investigated via the received Fokker–Planck–Kolmogorov (FPK) equation to compute the stationary solution of probability density functions with its shape changing from one peak to two peaks with the increase of noise intensity, and the phenomena of stochastic jump is consistent with the solution of frequency–amplitude response equations.
A New Surgical Technique for Repair of Aortic Coarctation

Field: Medicine (Health Sciences)

From June, 1987, to February, 1989, 7 patients underwent a new technique of coarctation repair. This technique consists of a complete mobilization of the left subclavian artery (LSA) so that it can be pulled down as much as possible. After all the proper clamping, the anterior wall of the aorta is incised longitudi nally, beginning on the anterior wall of the LSA and extending distally to the descending aorta 2 cm past the coarctation. The coarctation membrane is ex cised carefully. The LSA is pulled down so that the proximal end of the incision can come to the distal end. Then, this longitudinal incision is sutured trans versely with 5/0 polydiaxonone and continuous technique, widening the coarcta tion site and also preserving the blood flow to the left upper limb. If extreme tension occurs, the LSA is transected. After the aortoplasty is completed, a polytetrafluoroethylene (PTFE) graft in size of 6 or 8 mm is interposed between the proximal and the distal parts of the LSA, providing continuity. The ages of the patients ranged from eighteen months to twenty years (mean: 11.5 years) and their weights ranged from 11 to 83 kg (mean: 37 kg). There were no hospital deaths. There were no significant pressure gradients through the isthmic area after the operation. Mean follow-up was eighteen months, and all patients but 1 were in class I effort capacity (NYHA). The authors have also noticed good blood flow to the left upper limb, including 2 patients who have a PTFE graft interposed in their LSA. The authors' experience indicates that this technique could be a good alternative to the subclavian flap aortoplasty because of preservation of blood flow to the left upper limb.
A Case of El Duende: Art-Based Supervision in Addiction Treatment

Field: Health Professions (Health Sciences)

Addictions professionals are at risk for compassion fatigue and secondary traumatic stress. This arts-based research, enhanced with qualitative processes, explored the experience and benefits of El Duende process painting (EDPP) in clinical supervision with art therapists. Supervision consisted of eight sessions. Data included interviews and photographs taken of the EDPP process. Findings demonstrated that EDPP art therapy supervision was a space for integrative transformation. It promoted a psychologically safe place to cope with compassion fatigue and process secondary traumatic stress.
How to Take a “Portrait” of Interpersonal Synergies Formation? – Exemplar Data with Expert Badminton Doubles

Field: Psychology (Social Sciences)

In the last decades, previous research regarding interpersonal synergies formation has emerged under the Uncontrolled Manifold concept, identifying synergies formation based on a single combination of task elements. However, in social systems with redundant degrees of freedom, several combinations to stabilize a performance goal may be the most common picture. Thus, the main goal of this explorative study was to create a “portrait” of a set of task elements combinations (i.e., player’s positions and velocities) adopted to stabilize a performance goal (i.e., interpersonal distance) in expert badminton doubles, which is usually associated with synergies formation. The Uncontrolled Manifold concept was used for that purpose. Our results displayed that the created “portraits” did not display any pattern of interpersonal synergies. Moreover, for all the portraits there were combinations of task elements that had the primacy over the others. A primacy that changed with the rally length. For the shortest and for the longest rallies, the player’s velocity seemed to be more relevant to form interpersonal synergies, whereas for the middle length, both the player’s position and velocity were important for that purpose. Also, there were a decreasing of synergies strength with the increasing of the rally length.
Modeling of Frequency Shift in RF-MEMS Switches Under Residual Stress Gradient

Field: Engineering (Physical Sciences)

Residual stress gradient is unavoidable in thin-film based devices such as radio frequency (RF) micro electro mechanical systems (MEMS) switches. In this paper residual stress gradient is modelled which affect the frequency shift in RF-MEMS switches. Curvature of thinfilms are measured experimentally and then residual stress gradient is modelled analytically and using finite element modeller (FEM). A comparison between analytical model and FEM has been carried out by introducing the initial upward curvature due to residual stress in the model. Beams under residual stress gradient change the pull-in voltage and shows frequency shift which points out that underestimating such effects can lead to inaccurate design and analysis of RF-MEMS switches and subsystems.
FDG-PET of mouse breast cancers on ketogenic vs. standard chow diets, with or without added rapamycin.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

280 Objectives: Prior pilot studies have shown that ketogenic diets may stabilize PET 18F-FDG markers of progression in advanced cancers (1) without unsafe adverse effects and can inhibit cancer growth in vitro without adversely affecting normal cells(2). A ketogenic diet (KD) vs. a standard chow diet (SD), each with or without supplemental oral rapamycin (Rapa), were provided to mice in a model of breast cancer. The goal was to compare potential effects on PET-FDG uptake. Insulin inhibition, as is seen on a KD, can interfere with mTOR and other signaling molecules of growth and resistance to apoptosis within cancer cells. Further, ketone bodies have been demonstrated to have histone deacetylase inhibitor activity. We hypothesized that insulin inhibition due to carbohydrate restriction, as well as ketosis, would slow tumor growth vs. a standard diet. We also hypothesized that added rapamycin would have a synergistic effect on tumor inhibition. Synergies of KD with PI3K inhibitors in mouse models of cancer have also recently been published (3).
Methods: Mice with spontaneous breast cancers (transgenic mouse strain FVB/N-Tg (MMTV-PyVT) 634Mul/J), at 6 weeks of life, were begun on either a KD (<1% carbohydrate-CHO) vs. SD (55% CHO) (n=3 mice each), all with 10% protein. Additional groups of mice (n=3) on KD as well as SD were also assigned to supplemental Rapa 0.4 mM and 4 mM. Mice were imaged at 35 days after arrival, when tumors were palpable. Imaging was performed after injection of 100 uCi 18F-FDG on a Siemens Inveon MicroPET scanner. Breast tumor regions of interest (ROI’s) were drawn manually, and parameters measured were total breast tumor volume (TV) and total glycolytic volume (GV). GV was calculated = mean SUV x TV. Tumor volume was obtained solely for the purpose of calculating GV.
Results: Total tumor Glycolytic Volume (2857ul) on a KD was substantially and significantly (p<0.001) lower than the respective value for mice on a SD (7818ul). In mice with added rapamycin therapy, the GV for KD + R 0.4 mM was 2812ul, not significantly different from the KD without R; while the SD + R showed reduction in GV to 3005ul (from 7818ul). On 4 mM R, total GV for mice on the KD +R was 2233ul compared to GV for SD +R at 1930ul.
Conclusions: A ketogenic diet reduces the rate of tumor growth in mice with spontaneous breast tumors compared with standard mouse chow, as hypothesized. Adding orally ingested rapamycin further slowed growth rates of both groups, but differences due to the diets vanished. Rapamycin dominates the cancer inhibiting effects on glycolytic volume when added to a ketogenic diet as measured on 18F-FDG PET FDG scans.
Prediction of natural gas density using only three measurable properties: intelligence and mathematical approaches

Field: Energy (Physical Sciences)

Accurate determination of natural gas (NG) density is a very important issue in the NG custody transfer. In the conventional methods for density calculation such as laboratory methods and equation of state (EoS), the temperature, pressure, and NG composition are required as input parameters. However, measuring NG composition is a complicated and costly procedure. To overcome this problem, two novel approaches are proposed to calculate density without the need to measure NG composition. In these approaches, speed of sound, pressure, and temperature as three simple measurable properties are introduced as input variables. The main approach is developed based on the artificial neural network (ANN). Moreover, a mathematical correlation is also developed as the alternative approach. The results of these two approaches are validated by comparing them with experimental data. The validation results show that the average absolute percent deviation (AAPD) and root mean square error (RMSE) is 1.94% and 2.88 for the ANN approach and are 2.54% and 3.82 for the correlation approach. The results show that the ANN approach has high precision and the correlation approach has acceptable accuracy. On the other hand, the density calculations using these approaches have a significant error at low temperature and high pressure.
the Creative Commons Attribution Non-Commercial License

Field: Medicine (Health Sciences)

An ischemic foot can be developed by acute arterial occlusion. Given proper treatment within critical time, the patient can avoid foot amputation and death. Early proper diagnosis and treatment by family physician at the initial clinical interviewing is important in saving the affected leg and the life. Thrombosis and embolism are the common causes of acute arterial occlusion. Thrombosis mostly arises from underlying cardiac disease such as arrhythmia, coronary artery disease and valvular heart disease while arterial occlusion by embolism can be shown on a narrowed artery related with systemic atherosclerosis. Because the treatment options depend on the underlying cause of the acute ischemic foot, it is important to identify the cause of acute ischemic foot. At this paper, we reported a case that the cause of acute ischemic foot of the patient proved paroxysmal atrial fi brillation after some diagnostic tests.
Production Lycopene Dye São Caetano Melon (Momordica charantia L.) for Food Application

Field: Agricultural and Biological Sciences (Life Sciences)

Food industry use colorants are common because color appearance play an important role in the products acceptances. The aim of this work was to obtain lycopene dye from pulp São Caetano melon. Healthy and mature fruits were used, where pulp was removed from seed. After homogenization pulp, was used to extract lycopene, purification, identification, quantification, microencapsulation, characterization dye and its hygroscopic behavior application beverages. The analysis of São Caetano melon showed that it is an excellent source lycopene. Microscopy showed the encapsulation lycopene and the change in structure of pure maltodextrin encapsulated product. The main results show it was possible obtain powder dye with good hygroscopic characteristics strong red color, and easy apply drinks, with a result for similar color drinks already known in the market. São Caetano melon may be considered an option to the raw material for industrialization red dye used food industry.
An analysis of the transfer process of management development practices within multinationals : case studies of two British-based multinationals' operations in Russia

Field: Business, Management and Accounting (Social Sciences)

The thesis presents a study of the process of transfer of management development \n(MD) practices within multinational companies (MNCs). The study examines the \ninfluence of context on the nature of MD processes in MNCs. It considers the \ninfluence of institutional context on the ways in which MD practices are transferred \nand received in MNCs, and identifies further factors shaping MD practices and their \ntransfer process in MNCs. The findings challenge the notion that the transfer and \nstructuring of MD around a system, which aims at the development of a \nhomogeneous management cadre, is possible. \nThe research focuses on the transfer of four MD practices - recruitment, training and \ndevelopment, career management, and rewards and appraisal from two British-based \nMNCs operating in the fast moving consumer goods sector to their Russian \nsubsidiaries. The study involves qualitative comparative research into the behaviour \nof managers. The research identifies and analyses the MD models and MD practices \nbeing transferred to the subsidiaries and the influence of the institutional context on \nthe structuring of MD practices. Longitudinal research of the Russian subsidiaries' \ninternal dynamics following the transfer of management and MD practices from the \nparent company analyses the process of transfer and considers the ways in which \npractices transferred are received, resisted, misunderstood, and sustained in the \nsubsidiaries. \nThe thesis highlights the contextual embeddedness of MD processes and practices, \nand shows how MD practices in MNCs are structured by their national context. The \nresearch identifies how MD practices are also influenced by the business \nenvironment and the industrial sector, the history of the company, its organisational \nculture, and the management philosophy and organisation. The influence of the host \ncountry national context on the ways in which the transferred MD practices are \nreceived in the Russian subsidiaries is examined and the particular difficulty of \ntransferring training and development and career management strategies is identified. \nProcesses found to facilitate the transfer of practices include those that provide \ninterpretations and create meaning surrounding the practices transferred. The thesis \nargues that work practices are more than just a series of separate techniques and that \nthey also involve processes related to establishing relations and creating meaning.
Universal molecular Clostridioides difficile screening and overtreatment in solid organ transplant recipients

Field: Medicine (Health Sciences)

Abstract Background Screening for Clostridioides difficile (CD) colonization can be performed using molecular testing to identify the presence of microbial DNA of the toxin gene. Colonization rates for hospitalized patients are as high as 20% and may be considerably higher in solid organ transplant (SOT) recipients. Treatment for CD should be based on clinical disease and not colonization, yet clinicians may misinterpret a positive CD screen resulting in overtreatment. Objectives The objective of this analysis is to determine how often positive CD screens resulted in inappropriate treatment with oral vancomycin. Methods Clostridioides difficile screens were performed using the Xpert C difficile assay (Cepheid), a nucleic acid amplification testing method utilizing polymerase chain reaction (PCR), on peri‐rectal swabs for newly admitted patients. This was a single‐center cohort study of adult patients with CD screens hospitalized between July 2015 and November 2018. The primary outcome was the rate of inappropriate oral vancomycin treatment in all patients and in SOT recipients, defined as therapy in the absence of diarrhea. Results Of the 47 076 total CD screens reviewed, 1,921 were positive. In the SOT cohort, 58 of 329 screens were positive (4.1% vs 17.9%, P < .01). Of all patients with a positive CD screen, 20.1% (386/1921) were treated with oral vancomycin within 48 hours of swab collection. In the SOT cohort, 39.6% (23/58) with positive CD screens were treated with oral vancomycin within 48 hours. Of the SOT patients who received oral vancomycin, 39% (9/23) did not have true CD infection. Conclusion Solid organ transplant recipients were more likely to have CD colonization detected by peri‐rectal screening than the general inpatient population. SOT and non‐SOT patients were treated with oral vancomycin at similar rates in response to the positive screen. Nearly half of the oral vancomycin use in SOT recipients was likely overtreatment, but this finding is limited by the low number of patients in this cohort.
NURSING CARE OF ACUTE PAIN IN CLIENTS WITH ACUTE MYOCARDIAL INFARCTION IN THE ICCU ROOM, DR. SOEGIRI HOSPITALS LAMONGAN

Field: Nursing (Health Sciences)

Introduction: Severe pain in the center of the chest is found in acute myocardial infarction (AMI) clients. Chest pain is described as pressing, usually radiating to the jaw or teeth, shoulders, arms, and/or back. Purpose: to report a case study on nursing care of clients with acute pain in AMI clients in the ICCU Room of Dr. Soegiri Hospitals Lamongan. Methods: research using case studies. The sample used was one IMA client with acute pain. Data collection was obtained through interviews, observations, physical examinations and documentation studies. Result: the case shows that there are several gaps between the client's facts and the literature review. For the assessment of AMI clients in general there is no gap, nursing diagnoses lead to a priority, namely acute pain, with priority nursing actions taken, namely providing analgesic therapy and advising clients to perform distraction and relaxation techniques. Evaluation of the nursing diagnosis of acute pain, the problem was partially resolved on the third day. Conclusion: AMI clients in their care must be more careful in assessing and prioritizing patient needs, seriousness in implementation to avoid complications that may occur.