jimnoneill/paper-to-field-training huggingface dataset:
[Tumors in rheumatoid arthritis].

Field: Medicine (Health Sciences)

Benign (bTu) and malignant tumours (mTu) were studied in a randomised autopsy material of 161 patients with rheumatoid arthritis (RA). The tissue specimens were fixed in 8% formaldehyde solution at pH 7.6 and embedded in paraffin. The tumours were diagnosed histologically and confirmed by immunohistochemical methods. Five benign (3.1%), and thirteen malignant tumours (8.1%) found observed in 18 (11.2%) of 161 cases. There was no significant difference between laboratory parameters of patients with malignant tumours and without tumours. One benign (0.62%) and seven malignant (4.35%) tumours led to death in 8 (4.97%) of 18 cases altogether. Neoplasms were detected clinically in 8 of 18 cases (44.4 rel%). None of tumorous patients received immunosuppressive treatment and only five had gold (Tauredon) therapy. Paraneoplastic syndromes with rheumatoid complaints may be excluded by the onset and duration of RA and tumours. Benign neurogenic tumours and malignant bronchioloalveolar carcinoma were frequently associated with RA not treated by immunosuppressive drugs. Our data do not support the assumption of a high risk of malignant lymphomas associated with RA treated with immunosuppressive therapy.
Effects of patient accessible electronic health records on nurses’ work environment: a survey study on expectations in Sweden

Field: Health Professions (Health Sciences)

Objectives The introduction of information and communication technology influences the work environment of large groups of employees in healthcare. In Sweden, a national healthcare service providing patient accessible electronic health records (PAEHR) has been deployed, and this paper investigates nurses’ expected effects of this implementation. Setting Nurses associated with the Swedish Association of Health Professionals working in healthcare such as primary care, hospitals and midwives in Sweden. Before a full-scale national implementation of PAEHR, a web survey study was distributed nationally. The respondents represented all 21 Swedish regions. Questions included five-point Likert scale questions and open questions. Participants A survey link was distributed via email to 8460 registered nurses, midwives and union representatives in Sweden. The response rate was 35.4% (2867 respondents: registered nurses 84%; midwives 6%; chief position 5%; in projects 2% and other 3%). Three reminders were sent out, all of them increasing the response rate. A majority of the respondents were female (89.9%), 8.4% male, whereas 1.7% did not indicate their gender. 31.4% were under 40 years old, 53.8% 40–59 and 13.7% over 60. Results Data were analysed using exploratory factor analysis with principal component analysis as the extraction method. The analysis revealed three distinct factors related to nurses’ expectations of PAEHR: (1) PAEHR improves the quality of care, (2) PAEHR improves the quality of the work environment and (3) risk and fears concerning patients’ well-being. Some interesting results include that more experienced nurses are more favourable to PAEHR. Our analysis also shows that the view of the nurse–patient relationship is an essential underlying factor related to positive or negative expectations. Conclusions Results show that the expectations and perceptions of PAEHR vary depending on the nurse’s view of who the electronic record belongs to. Younger nurses are somewhat more negative towards PAEHR than older nurses.
Temperature Decay and Recombination in Helium Afterglow Plasmas

Field: Physics and Astronomy (Physical Sciences)

The effect of the temperature of the neutral gas on the decay of electron temperature and density in helium afterglow plasmas ($p=0.3\ensuremath{-}0.7$ Torr, ${N}_{e}\ensuremath{\approx}{10}^{13}$ ${\mathrm{cm}}^{\ensuremath{-}3}$, ${T}_{e}\ensuremath{\approx}2000\ifmmode^\circ\else\textdegree\fi{}$K) is investigated. Density and temperature of the electrons and the concentration of metastable atoms are measured with optical and microwave methods; the gas temperature is determined from standing acoustic waves excited by the discharge. In the investigated range no difference is found during the afterglow between the temperatures of the electrons and of the gas which is heated in the discharge. The slow electron-temperature decay follows the decay of the elevated gas temperature controlled by heat conduction, and is not affected by electron-heating processes due to metastable atoms and recombination. With collisional-radiative recombination as the major plasma loss mechanism, the plasma decay can be approximately predicted from the initial density and temperature.
Fragmentary Sequences for Variable-Sized RNAsim Datasets

Field: Computer Science (Physical Sciences)

Thank you for using these datasets. These RNAsim aligned fragmentary sequences were generated from the query sequences selected by Balaban et al. (2019) in their variable-size datasets (https://doi.org/10.5061/dryad.78nf7dq). They were created for use for phylogenetic placement with the multiple sequence alignments and backbone trees provided by Balaban et al. (2019). The file structures included here also correspond with the data Balaban et al. (2020) provided. This includes: Directories for five varying backbone tree sizes, shown as 5000, 10000, 50000, 100000, and 200000. These directory names are also used by Balaban et al. (2019), and indicate the size of the backbone tree included in their data. Subdirectories for each replicate from the backbone tree size labelled 0 through 4. For the smaller four backbone tree sizes there are five replicates, and for the largest there is one replicate. Each replicate contains 200 text files with one aligned query sequence fragment in fasta format.
Stability Analysis in a Technology Transfer Model with Competing Followers

Field: Mathematics (Physical Sciences)

We present the stability analysis for solution of a mathematical model of technology transfer. The model takes form in a system of differential equations. We assume that there are two competing followers with logistic growth function of technological development for all parties involved. The analysis of the model is done via dynamical system approach by emphasizing the long-term behaviour of the system. In this paper the stability analysis of the system will be investigated. A crisp initial condition for each of the followers is assumed to show that there are two stable non-trivial equilibrium points. Both of them are co-existence equilibrium solutions, which indicates a plausible model. Some numerical examples are presented to illustrated properties of the model.
“They said I came back Americanized”: cosmopolitanism and mediation in the trajectory of Carmen Miranda

Field: Arts and Humanities (Social Sciences)

This paper analyzes Carmen Miranda’s trajectory by situating it in the broader context of the disputes about Brazilian nationality between 1920 and 1940. At the intersection between her career and the Brazilian political culture of her time, the paper discusses her role in mediating the symbols that contributed to a particular national project that made the samba the country’s unmistakable trademark.
A Study on the Utilization of Metaverse in Dance Education

Field: Arts and Humanities (Social Sciences)

연구목적 본 연구는 메타버스의 개념과 특징을 알아보고 무용교육에서의 메타버스 활용에 대한 교육적 가치를 논의하는데 목적이 있다. 연구방법 연구목적을 달성하기 위해 사례조사 연구방법을 활용하여 교육분야에서의 메타버스 활용 사례를 제시하고 이를 토대로 무용교육에서의 활용 방안을 도출하였다. 결과 다양한 메타버스 활용 사례를 통해 다음과 같은 결과를 도출하였다. 첫째, 증강현실을 통한 무용공연 관람을 제안한다. 둘째, 가상현실을 활용하여 체험 기회를 제공한다. 셋째, 아바타를 활용한 온·오프라인 블렌디드 학습방식을 제안한다. 넷째, 빅데이터와 인공지능을 기반한 무용창작수업을 제안한다. 결론 무용교육에서 메타버스 활용은 교육적 가치가 있으며, 메타버스 기반 무용교육 프로그램 개발과 보급이 절실하다는 것을 확인할 수 있었다. 메타버스를 통한 새로운 교육방식은 학습자의 흥미와 참여를 높여 교육적 효과를 극대화시킬 것이다. 아울러 시대에 부응하여 무용교육의 대중화를 선도하며 무용교육의 질적 제고에 도움을 줄 것이다.
A novel protein Moat prevents ectopic epithelial folding by limiting Bazooka/Par3-dependent adherens junctions

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Contractile myosin and cell adhesion work together to induce tissue shape changes, but how they are patterned to achieve diverse morphogenetic outcomes remains unclear. Epithelial folding occurs via apical constriction, mediated by apical contractile myosin engaged with adherens junctions, as in Drosophila ventral furrow formation. While it has been shown that a multicellular gradient of myosin contractility determines folding shape, the impact of multicellular patterning of adherens junction levels on tissue folding is unknown. We identified a novel Drosophila gene moat essential for differential apical constriction and folding behaviors across the ventral epithelium which contains both folding ventral furrow and nonfolding ectodermal anterior midgut (ectoAMG). We show that Moat functions to downregulate polarity-dependent adherens junctions through inhibiting cortical clustering of Bazooka/Par3 proteins. Such downregulation of polarity-dependent junctions is critical for establishing a myosin-dependent pattern of adherens junctions, which in turn mediates differential apical constriction in the ventral epithelium. In moat mutants, abnormally high levels of polarity-dependent junctions promote ectopic apical constriction in cells with low-level contractile myosin, resulting in expansion of infolding from ventral furrow to ectoAMG, and flattening of ventral furrow constriction gradient. Our results demonstrate that tissue-scale distribution of adhesion levels patterns apical constriction and establishes morphogenetic boundaries.
Impact of Cognitive Ability and Self-Pacing on Occluded Quasi-Driving Task Performance

Field: Psychology (Social Sciences)

We examined the role of cognitive ability in moderating the effects of occlusion on quasi-driving performance. Two experiments were conducted where we tested for executive function (EF) ability (shifting, updating, and inhibition), before presenting a one-dimensional pedal tracking task with a cognitive secondary task (N-back). The first experiment used self-paced occlusion (SPO), and the second experiment used forced occlusion (FO). The results showed strong individual differences. With SPO, we found that higher updating ability led to worse pedal tracking performance, likely because of insufficient visual sampling. In contrast, higher updating ability in FO was related to better pedal tracking stability. Our findings suggest that people with higher cognitive ability may sometimes carry out insufficient visual sampling when driving, either because they are more prone to distraction by cognitive tasks or because they are overly confident in their ability to manage the primary task with lower amounts of visual information.
145. Notes on the vocalizations of Northern Scrub-flycatcher (Sublegatus arenarum), Amazonian Scrub-flycatcher (Sublegatus obscurior) and Southern Scrub-flycatcher (Sublegatus modestus)

Field: Agricultural and Biological Sciences (Life Sciences)

Notes on the vocalizations ofNorthern Scrub-flycatcher (Sublegatus arenarum), Amazonian Scrub-flycatcher (Sublegatus obscurior) and Southern Scrub-flycatcher (Sublegatus modestus)
One-Pot, One-Step Production of Dietary Nucleotides by Magnetic Biocatalysts

Field: Chemical Engineering (Physical Sciences)

The enzymatic synthesis of nucleotides offers several advantages over traditional multistep chemical methods, such as stereoselectivity, regioselectivity, enantioselectivity, simple downstream processing, and the use of mild reaction conditions. However, in order to scale up these bioprocesses, several drawbacks, such as the low enzyme stability and recycling, must be considered. Enzyme immobilization may overcome these cost-related problems by enhancing protein stability and facilitating the separation of products. In this regard, tetrameric hypoxanthine–guanine–xanthine phosphoribosyltransferase (HGXPRT) from Thermus thermophilus HB8 was covalently immobilized onto glutaraldehyde-activated MagReSyn®Amine magnetic iron oxide porous microparticles (MTtHGXPRT). In this context, two different strategies were followed: (a) an enzyme immobilization through its N-terminus residues at pH 8.5 (derivatives MTtHGXPRT1-3); and (b) a multipoint covalent immobilization through the surface lysine residues at pH 10 (derivatives MTtHGXPRT4-5). The immobilized derivatives of MTtHGXPRT3 (activity 1581 international units per gram of support, IU/g; retained activity 29%) and MTtHGXPRT5 (activity 1108 IU/g; retained activity 23%) displayed the best wet biocatalyst activity, and retained activity values in the enzymatic synthesis of inosine-50 -monophosphate (IMP). In addition, the dependence of the activities and stabilities of both derivatives on pH and temperature was tested, as well as their reusability potential. Taking these results into account, MTtHGXPRT3 was chosen as the best biocatalyst (negligible loss of activity at 60 ◦C during 24 h; reusable up to seven cycles). Finally, as proof of concept, the enzymatic production of dietary nucleotides from high concentrations of low soluble bases was achieved.
Grain Boundary Diffusion of Magnesium in Zirconia

Field: Materials Science (Physical Sciences)

This paper reports the transport kinetics of Mg in cubic yttria‐stabilized zirconia (containing 10% mol of Y 2 O 3 (10YSZ)) involving the bulk and the grain boundary diffusion coefficients. The diffusion‐controlled concentration profiles of Mg were determined using secondary ion mass spectrometry (SIMS) in the range 1073–1273 K. The determined bulk diffusion coefficient and the grain boundary diffusion product may be expressed as the following functions of temperature, respectively: D = 5.7 exp[(−390 kJ/mol)/ RT ] cm 2 ·s −1 and D ′αδ= 3.2 × 10 −15 exp[(−121 kJ/mol)/ RT ] cm 3 ·s −1 , where α is the segregation enrichment factor and δ is the boundary layer thickness. The grain boundary enhancement factor decreases with temperature from 10 5 at 1073 K to 10 3 at 1273 K.
The Structure of D-Glucosyl-D-xylose Synthesized by Maltose Phosphorylase1

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure of D-Glucosyl-D-xylose Synthesized by Maltose Phosphorylase1E. W. Putman, Charlotte Fitting Litt, and W. Z. HassidCite this: J. Am. Chem. Soc. 1955, 77, 16, 4351–4353Publication Date (Print):August 1, 1955Publication History Published online1 May 2002Published inissue 1 August 1955https://pubs.acs.org/doi/10.1021/ja01621a050https://doi.org/10.1021/ja01621a050research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
MANIPULATIVE MANEUVERS OF THE KNEE FOR REPLACING DISPLACED MENISCUSES

Field: Medicine (Health Sciences)

To the Editor:— In February, 1944, at Mayo General Hospital, I saw many Air Corps trainees and medical service enlisted men with acute displacement of the knee meniscuses. For years I had been disappointed with the 1-2-3 kick technique because it adds insult to injury. I decided to try the McMurray maneuvers. So far they have not failed. It is a case of using a diagnostic test as a therapeutic maneuver. My routine was quickly established. If synovitis or hemarthrosis were present, I aspirated via the suprapatellar pouch. In every swollen, injured knee, blood might be found. Immediate reduction of the displaced meniscus is advisable. After this a long leg cast is applied. Operation may be postponed a few days. Anesthesia is usually induced intravenously with thiopental (Pentothal) sodium. The patient is placed in a supine position with a pillow placed lengthwise to maintain flexion of the knee. The surgeon
Legal Aspects of Cooperation Agreement on Cultivation of Siwalan Orchard Land in Sumenep Regency

Field: Social Sciences (Social Sciences)

Based on the provisions of Article 1313 of the Criminal Code that an agreement is binding on both parties like a law, meaning it gives rise to rights and obligations for the parties who make it, because basically every agreement must be kept. One of the agreements that have long existed in the community is a plantation land management agreement in the form of a cooperation agreement implemented in the village of Pragaan Daya, Pragaan District, Sumenep regency for the cultivation of siwalan orchard land. In this journal applies the method of empirical juridical approach, namely legal research that obtains its data from primary data or data or data obtained directly from the public in this study found some applications that have not been in accordance with applicable legal rules where in its application, the form of agreements that should be made in writing but only made orally. This is due to the lack of human resources in the field of employment and the desire of the landowner himself to make a work agreement for a certain time orally, given the existence of this written agreement can certainly provide legal certainty to siwalan workers, especially if later when in the field something happens that can harm them, they can ask for the work Agreement and the result of the violation of the agreement that occurred in the cooperation agreement called default can be resolved amicably, non-litigation or litigation.
Potential and Limitations of Grasslands α-Diversity Prediction Using Fine-Scale Hyperspectral Imagery

Field: Environmental Science (Physical Sciences)

Plant biodiversity is an important feature of grassland ecosystems, as it is related to the provision of many ecosystem services crucial for the human economy and well-being. Given the importance of grasslands, research has been carried out in recent years on the potential to monitor them with novel remote sensing techniques. In this study, the optical diversity (also called spectral diversity) approach was adopted to check the potential of using high-resolution hyperspectral images to estimate α-diversity in grassland ecosystems. In 2018 and 2019, grassland species composition was surveyed and canopy hyperspectral data were acquired at two grassland sites: Monte Bondone (IT-MBo; species-rich semi-natural grasslands) and an experimental farm of the University of Padova, Legnaro, Padua, Italy (IT-PD; artificially established grassland plots with a species-poor mixture). The relationship between biodiversity (species richness, Shannon’s, species evenness, and Simpson’s indices) and optical diversity metrics (coefficient of variation-CV and standard deviation-SD) was not consistent across the investigated grassland plant communities. Species richness could be estimated by optical diversity metrics with an R = 0.87 at the IT-PD species-poor site. In the more complex and species-rich grasslands at IT-MBo, the estimation of biodiversity indices was more difficult and the optical diversity metrics failed to estimate biodiversity as accurately as in IT-PD probably due to the higher number of species and the strong canopy spatial heterogeneity. Therefore, the results of the study confirmed the ability of spectral proxies to detect grassland α-diversity in man-made grassland ecosystems but highlighted the limitations of the spectral diversity approach to estimate biodiversity when natural grasslands are observed. Nevertheless, at IT-MBo, the optical diversity metric SD calculated from post-processed hyperspectral images and transformed spectra showed, in the red part of the spectrum, a significant correlation (up to R = 0.56, p = 0.004) with biodiversity indices. Spatial resampling highlighted that for the IT-PD sward the optimal optical pixel size was 1 cm, while for the IT-MBo natural grassland it was 1 mm. The random pixel extraction did not improve the performance of the optical diversity metrics at both study sites. Further research is needed to fully understand the links between α-diversity and spectral and biochemical heterogeneity in complex heterogeneous ecosystems, and to assess whether the optical diversity approach can be adopted at the spatial scale to detect β-diversity. Such insights will provide more robust information on the mechanisms linking grassland diversity and optical heterogeneity.
Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

A fully human IgG2kappa monoclonal antibody (MAb), E7.6.3, specific to the human epidermal growth factor (EGF) receptor (EGFr) was generated from human antibody-producing XenoMouse strains engineered to be deficient in mouse antibody production and to contain the majority of the human antibody gene repertoire on megabase-sized fragments from the human heavy and kappa light chain loci. The E7.6.3 MAb exhibits high affinity (KD = 5 x 10(-11) M) to the receptor, blocks completely the binding of both EGF and transforming growth factor alpha (TGF-a) to various EGFr-expressing human carcinoma cell lines, and abolishes EGF-dependent cell activation, including EGFr tyrosine phosphorylation, increased extracellular acidification rate, and cell proliferation. The antibody (0.2 mg i.p. twice a week for 3 weeks) prevents completely the formation of human epidermoid carcinoma A431 xenografts in athymic mice. More importantly, the administration of E7.6.3 without concomitant chemotherapy results in complete eradication of established tumors as large as 1.2 cm3. Tumor eradication of A431 xenografts was achieved in nearly all of the mice treated with total E7.6.3 doses as low as 3 mg, administered over the course of 3 weeks, and a total dose of 0.6 mg led to tumor elimination in 65% of the mice. No tumor recurrence was observed for more than 8 months after the last antibody injection, which further indicated complete tumor cell elimination by the antibody. The potency of E7.6.3 in eradicating well-established tumors without concomitant chemotherapy indicates its potential as a monotherapeutic agent for the treatment of multiple EGFr-expressing human solid tumors, including those for which no effective chemotherapy is available. Being a fully human antibody, E7.6.3 is expected to exhibit minimal immunogenicity and a longer half-life as compared with mouse or mouse-derivatized MAbs, thus allowing repeated antibody administration, including in immunocompetent patients. These results suggest E7.6.3 as a good candidate for assessing the full therapeutic potential of anti-EGFr antibody in the therapy of multiple patient populations with EGFr-expressing solid tumors.