jimnoneill/paper-to-field-training huggingface dataset:
Anna and Dr Helmy

Field: Arts and Humanities (Social Sciences)

Abstract This book tells the story of Mohammed Helmy, an Egyptian doctor who lived in Berlin during the Second World War and walked the fine line between accommodation to the Nazi regime and subversion of it. It mentions the Israeli holocaust memorial at Yad Vashem that honoured more than 25,000 of the non-Jewish men and women who saved Jewish people during the war. It also describes Helmy as a master of deception, outfoxing the Nazis and risking his own life to save his Jewish colleagues and other Jewish Berliners from Nazi persecution. The book reveals a wider story of the Arab community in Berlin at the time, many of whom had warm relations with the Jewish community. It details how Helmy and the Arab community risked their lives to help their Jewish friends when the Nazis rose to power.
Rotavirus Shedding in Feces of Gnotobiotic Calves Orally Inoculated with a Commercial Rotavirus-Coronavirus Vaccine

Field: Veterinary (Health Sciences)

The purpose of this study was to monitor by negative stain electron microscopy the shedding of rotavirus in the feces of gnotobiotic calves orally inoculated with a commercial modified live bovine rotavirus-bovine coronavirus vaccine. Negative stain electron microscopic examination detected vaccine rotavirus in only 1 of 41 daily fecal specimens collected from 3 gnotobiotic calves during the 2 weeks following oral inoculation with a US Department of Agriculture-licensed modified live bovine rotavirus-bovine coronavirus vaccine. In contrast, rotavirus was demonstrable by the same negative stain electron microscopic examination procedure in 17 of 19 fecal specimens collected from diarrheic gnotobiotic or colostrum-deprived calves during the first 8 days after inoculation with virulent bovine rotavirus field strains. Rotavirus was also detected by this procedure in 4 enzyme-linked immunosorbent assay positive fecal specimens collected from naturally-infected diarrheic dairy calves. These results suggest that fecal shedding of vaccine rotavirus demonstrable by electron microscopic examination is uncommon following oral inoculation of calves with the bovine rotavirus-bovine coronavirus vaccine.
RJR-2403: A CNS-Selective Nicotinic Agonist with Therapeutic Potential

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

In recent years molecular cloning studies have resulted in the discovery of multiple genes encoding a variety of structural and functional subunits for nicotinic cholinergic receptors (nAChR) (Galzi and Changeux, 1995), 11 having neuronal localization (α2–α9, β2–β4) and 5 expressed in skeletal muscle (α1, β1,γ, δ, ε). This molecular diversity opens up the possibility of complex receptor subtype expression both in the autonomic (PNS) and central (CNS) nervous systems, possibly explaining the complex pharmacological effects of nicotine and other classic nicotinic cholinergic agonists that do not discriminate among the various receptor subtypes expressed in the CNS and PNS. The importance of understanding this complexity is emphasized by the growing body of evidence suggesting that compromised CNS nicotinic cholinergic neurotransmission may play a key role in a variety of CNS and PNS pathologies. In this regard, there is growing interest in the use of nicotinic agonists for the treatment of Alzheimer's disease (AD) (Williams et al., 1994). One consistent feature of this disease is a decline in the function of cholinergic systems. The loss of neurons that release acetylcholine, a key neurotransmitter in learning and memory mechanisms, initially motivated an intense but disappointing search for replacement therapies targeting muscarinic receptors. On the other hand, epidemiological studies have reported an inverse correlation between the incidence of AD and smoking (van Duijn and Hofman, 1991), supporting the notion that nicotinic pharmacology underlies an apparent protective effect.
Arts-based Methods in Socially Engaged Research Practice: A Classification Framework

Field: Arts and Humanities (Social Sciences)

Arts-based research has recently gained an increasing popularity within qualitative inquiry. It is applied in various disciplines, including health, psychology, education, and anthropology. Arts-based research uses artistic forms and expressions to explore, understand, represent, and even challenge human experiences. In this paper we aim to create order in the messy field of artistically inspired methods of socially engaged research. We review literature to establish study and distinguished three major categories for classifying arts-based research: research about art, art as research, and art in research. We further identify five main forms of arts-based research: visual art, sound art, literary art, performing art, and new media. Relevant examples of socially engaged research are provided to illustrate how different artistic methods are used within the forms identified. This classification framework provides artists and researchers a general introduction to arts-based research and helps them to better position themselves and their projects in a field in full development.
Pengaruh Penggunaan Media Roulette Angka Terhadap Kemampuan Kognitif Anak dalam Mengenal Lambang Bilangan pada Kelompok B Usia 5-6 Tahun TK Pelangi Medan T.A 2023/2024

Field: Social Sciences (Social Sciences)

<em>The results of this study indicated that there was a difference in the level of cognitive ability of children in recognizing number symbols in Group B, aged 5-6 years, at TK Pelangi Medan, where learning activities were conducted using number roulette media. The children were given 2 treatment periods using the number roulette media and 2 treatment periods without using the roulette media. In the first period (X<sub>1</sub>O<sub>1</sub>), children who received treatment scored an average of 9.43, which falls into the fairly good category. In the second period (X<sub>0</sub>O<sub>2</sub>), without treatment using the roulette media, the children scored an average of 6.12, which falls into the less good category. In the third period (X<sub>1</sub>O<sub>3</sub>), children who received treatment scored an average of 17.62, which falls into the very good category, and in the fourth period (X<sub>0</sub>O<sub>4</sub>), without treatment using the roulette media, the children scored an average of 14.37, which falls into the good category.The data scores indicate that the use of number roulette media has a significant effect on the cognitive ability of children in Group B, aged 5-6 years, at TK Pelangi in recognizing number symbols. This is evidenced by the SPSS output, which shows that the Asymp. Sig (2-tailed) value is 0.000. Since the value 0.000 is less than 0.005, Ha is accepted, meaning there is a significant difference in the average learning outcomes before and after treatment. Therefore, it can be said that "there is a significant effect through the use of number roulette media on the cognitive ability of children in recognizing number symbols in Group B, aged 5-6 years, at TK Pelangi Medan during the 2023/2024 academic year</em>
A comprehensive collection of annotations to interpret sequence variation in human mitochondrial transfer RNAs

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Background The abundance of biological data characterizing the genomics era is contributing to a comprehensive understanding of human mitochondrial genetics. Nevertheless, many aspects are still unclear, specifically about the variability of the 22 human mitochondrial transfer RNA (tRNA) genes and their involvement in diseases. The complex enrichment and isolation of tRNAs in vitro leads to an incomplete knowledge of their post-transcriptional modifications and three-dimensional folding, essential for correct tRNA functioning. An accurate annotation of mitochondrial tRNA variants would be definitely useful and appreciated by mitochondrial researchers and clinicians since the most of bioinformatics tools for variant annotation and prioritization available so far cannot shed light on the functional role of tRNA variations. Results To this aim, we updated our MToolBox pipeline for mitochondrial DNA analysis of high throughput and Sanger sequencing data by integrating tRNA variant annotations in order to identify and characterize relevant variants not only in protein coding regions, but also in tRNA genes. The annotation step in the pipeline now provides detailed information for variants mapping onto the 22 mitochondrial tRNAs. For each mt-tRNA position along the entire genome, the relative tRNA numbering, tRNA type, cloverleaf secondary domains (loops and stems), mature nucleotide and interactions in the three-dimensional folding were reported. Moreover, pathogenicity predictions for tRNA and rRNA variants were retrieved from the literature and integrated within the annotations provided by MToolBox, both in the stand-alone version and web-based tool at the Mitochondrial Disease Sequence Data Resource (MSeqDR) website. All the information available in the annotation step of MToolBox were exploited to generate custom tracks which can be displayed in the GBrowse instance at MSeqDR website. Conclusions To the best of our knowledge, specific data regarding mitochondrial variants in tRNA genes were introduced for the first time in a tool for mitochondrial genome analysis, supporting the interpretation of genetic variants in specific genomic contexts.
Bilateral cooperation between Brazil and african countries: quantitative analysis

Field: Social Sciences (Social Sciences)

The article sheds light upon the relations between Brazil and African continent.The author points out the economic cooperation`s rate and sums up the state of political ties.A special and particular attention is paid to the cooperation agreements, as well as to official trips made by Brazilian presidents to African countries from 1985 to 2022 year.The author comes round to thinking that Africa holds the third position in Brazilian foreign policy, followed by Latin America (the first position) and Europe (the second one).He underscores that trade growth took place only in the 1980s and during Luiz Inásio Lula da Silva's presidential terms.Brazil has the most active cooperation with Portuguese-speaking African countries, South Africa, Nigeria and Morocco.The electoral victory of Lula makes gather that Africa again will be one of Brazil`s important partners after the years of being misused and nearly forgotten by Jair Bolsonaro`s government.
Education and the minimum wage in the United States

Field: Economics, Econometrics and Finance (Social Sciences)

This article shows that, across the US states, the level of education has a causal effect on the minimum wage. More specifically, it argues that a one-percentage point increase in the proportion of college graduates implies a 0.4–0.5% decrease in the real value of the minimum wage. This is the first article that uses System GMM in order to examine the effect of education on the minimum wage. Given the structure of the available data, this is the most appropriate econometric technique. System GMM not only controls for endogeneity and for fixed effects but also maximizes the precision of the estimates by using all the available variation in the data.
Climate dominates geographic influences on whitebark pine and limber pine trends and landscape patterns in Canada

Field: Environmental Science (Physical Sciences)

Limber pine (LP; Pinus flexilis) and whitebark pine (WBP; Pinus albicaulis) are classified as endangered in Canada due to rapid declines caused by the introduced pathogen causing white pine blister rust (WPBR; Cronartium ribicola), mountain pine beetle, and other stressors. A long-term monitoring study from 2003 to 2019 on 102 LP and 232 WBP permanent plots found that LP mortality decreased with increasing latitude and spring solar radiation, while WBP mortality was highest at low latitudes and elevations in areas with higher moisture and longer growing degree days. WPBR incidence in LP was associated with lower latitudes, high spring precipitation, cool/wet summers, and low solar radiation, while WBP disease incidence drivers were similar, plus increasing tree diameter and slope. Annually, mature LP and WBP mortality from all causes increased 0.4% and 0.5%, respectively, while disease incidence in live trees increased 0.6% and 0.5%. Regeneration density increased 1.3% annually on average for WBP and 2.5% for LP. Disease incidence and mortality rates have slowed compared to prior assessments, likely due to a recruitment deficit of healthy trees and some natural selection for blister rust resistance. The results support customizing landscape restoration strategies based on each species’ unique biology and local climatic factors that influence mortality and infection.
Safety and clinical activity of target-preserving anti-CTLA-4 antibody ONC-392 as monotherapy in NSCLC patients who progressed on PD(L)1-targeted immunotherapy.

Field: Medicine (Health Sciences)

9024 Background: PD-1 or PD-L1 inhibitors have transformed clinical care of NSCLC patients. However, many patients may develop primary or secondary resistant to PD-(L)1 inhibitors. The marketed anti-CTLA-4 mAbs are ineffective as monotherapy for NSCLC. ONC-392 is a novel target-preserving anti-CTLA-4 antibodies that confers immunotherapeutic effect by selective depletion of regulatory T cells (Treg) in the tumor microenvironment. Preclinical studies show that ONC-392 is more effective and less toxic for immunotherapy than other clinically used anti-CTLA-4 antibodies. In first-in-human study in patients with advanced solid cancer, the recommended Phase 2 dose (RP2D) for ONC-392 monotherapy was established as 10 mg/kg. In this study, we tested safety and clinical activities of ONC-392 in NSCLC patients who progressed on PD(L)1-targeted therapy. Methods: Anti-PD-(L)1 resistant NSCLC patients were enrolled as parts of PRESERVE-001 studies (NCT04140526) expansion cohort Part C Arm I and treated with 2 cycles of 10 mg/kg, followed by 6 mg/kg, q3w, ONC-392 by IV infusion. Safety was evaluated based on treatment emergent and treatment-related adverse events, while efficacy was evaluated by investigators using RECIST1.1 criteria. Results: As of December 18, 2022, 33 NSCLC patients have received at least one dose of ONC-392 at 10 mg/kg. The median age is 66 yrs (range 43 - 89 yr), 61% male. 61% were non-squamous cell carcinoma and 39% were squamous cell carcinoma. 27% are ECOG score 0 and 73% were ECOG score 1. The median prior treatment was 2 cycles (range 1 to 4). The average ONC-392 treatment period was 3.5 cycles (range 1 to 13 cycles). Overall, the patients with TRAE in grade 3 or above is 33% (11/33), including diarrhea/colitis (3, 9%), AST/ALT increase or hepatitis (3, 9%), muscular weakness (2, 6%), nephritis (1, 3%), adrenal insufficiency (1, 3%). Due to pace of enrollment, efficacy data are available in 22 patients. 6 of 22 evaluable patients have partial response and 12 patients have stable disease per RECIST 1.1, resulting in a response rate of 27% and disease control rate of 82% among evaluable patients. The median follow-up period for all patients is 5.8 months and 8.6 months for 20 alive patients (range 2.9 to 14.1 months). The estimated 6- and 12-month overall survival (OS) rates were 65% and 55%. Median OS has not reached. Conclusions: Overall, ONC-392 monotherapy with 10 mg/kg is safe and tolerable. Onc-392 monotherapy has showed encouraging anti-tumor activity in IO-resistant NSCLC when compared with historical data. Based on these encouraging data, we have initiated a Phase 3 study testing ONC-392 monotherapy among NSCLC who progressed on PD(L)1-targeting immunotherapy (NCT05671510). Clinical trial information: NCT04140526 .
ROI centered compression by Adaptive Quantization for sports video

Field: Computer Science (Physical Sciences)

In this paper, we propose a region of interest (ROI) centered compression method for sports video. First we track a center of ROI using Dynamic Kalman Filter (DKF) Algorithm that we proposed previously, determine ROI macro blocks (MBs) and finally quantize each MB adaptively with rate control. Experimental results show that our proposed algorithm presents increased clearness in the ROI than uniform quantization methods while maintaining stable bit-rate.
A Closer Look at Dark Vector Splitting Functions in Proton Bremsstrahlung

Field: Physics and Astronomy (Physical Sciences)

High luminosity colliders and fixed target facilities using proton beams are sensitive to new weakly coupled degrees of freedom across a broad mass range. Among the various production modes, bremsstrahlung is particularly important for dark sector degrees of freedom with masses between 0.5 and 2.0 GeV, due to mixing with hadronic resonances. In this paper, we revisit the calculation of dark vector production via initial state radiation in non-single diffractive scattering, using an improved treatment of the splitting functions and timelike electromagnetic form-factors. The approach is benchmarked by applying an analogous calculation to model inclusive $ρ$-meson production, indicating consistency with data from NA27 in the relevant kinematic range.
Site Specific Acetylation of p53 Directs Selective Transcription Complex Assembly on p53 Target Gene Promoters

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Two hydroxamic acid HDAC inhibitors CG‐1521 and TSA stabilize the acetylation of Ac‐Lys373 and Ac‐Lys382 p53 respectively in both LNCaP and MCF‐7 cells. Stabilization of Ac‐Lys373 p53 induces p53‐dependent increase in p21 levels, cell cycle arrest and cell death. In contrast TSA which stabilizes Ac‐Lys382 p53 induces p21 and cell cycle arrest, but not cell death. Transcriptome‐wide analysis and RT‐PCR has shown that CG‐1521 induces the transcription of several p53 target genes including p21, p21B and Bnip3l, while TSA does not alter the steady state level of p21 or p21B mRNA, and downregulates Bnip3l mRNA expression. Co‐IP and ChIP analyses using anti‐Ac‐Lys373 p53 and anti‐Ac‐Lys282 p53 specific antibodies show that CG‐1521 and TSA initiate the formation of mutually exclusive transcriptional complexes on the p53REs in the p21, p21B and Bnip3l promoters in both cell lines. Furthermore, these complexes directly affect the recruitment of the components of the basal transcription apparatus to the basal promoter in the p21 gene with markedly different outcomes. The transcription complex associated with Ac‐Lys382 p53 after treatment with TSA does not recruit RNA Pol II or TFIIH to the basal promoter, while Ac‐Lys373 p53 promotes the assembly of an active basal transcriptional complex. These data suggest a novel and critically important role for protein acetylation/deacetylation in the assembly of active transcription processes that can be exploited in the development of new adjuvant therapies for cancer. (supported by the Coleman Foundation and Errant Gene Therapeutics)
Does an antibody molecule act as a template directing (determining) its glycosylation ?

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Conference Article| May 01 1992 Does an antibody molecule act as a template directing (determining) its glycosylation ? Roy Jefferis; Roy Jefferis 1Department of Immunology, The Medical school, Edgbaston, Birmingham B15 2TT Search for other works by this author on: This Site PubMed Google Scholar Noriko Takahashi; Noriko Takahashi +Nagoya City University College of Nursing, Mizuho-ku, Nagoya 467, Japan Search for other works by this author on: This Site PubMed Google Scholar John Lund; John Lund 1Department of Immunology, The Medical school, Edgbaston, Birmingham B15 2TT Search for other works by this author on: This Site PubMed Google Scholar Ruth Tyler; Ruth Tyler 1Department of Immunology, The Medical school, Edgbaston, Birmingham B15 2TT Search for other works by this author on: This Site PubMed Google Scholar Siobhan Hindley Siobhan Hindley 1Department of Immunology, The Medical school, Edgbaston, Birmingham B15 2TT Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1992) 20 (2): 228S. https://doi.org/10.1042/bst020228s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Roy Jefferis, Noriko Takahashi, John Lund, Ruth Tyler, Siobhan Hindley; Does an antibody molecule act as a template directing (determining) its glycosylation ?. Biochem Soc Trans 1 May 1992; 20 (2): 228S. doi: https://doi.org/10.1042/bst020228s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1992 Biochemical Society1992 Article PDF first page preview Close Modal You do not currently have access to this content.
A Comparative Meta‐Analysis on the Association of lncRNAs MALAT1, HOTAIR, and AFAP1‐AS1 With the Risk of Developing Lymph Node Metastasis in Lung Cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ABSTRACT Background Numerous studies have demonstrated the significance of long noncoding RNA (lncRNA) in the development of cancer metastasis. The expression levels of many lncRNAs are elevated in metastatic lung cancer patients compared to non‐metastatic lung cancer patients. Objectives The primary objective of the study was to investigate the association between the expression levels of three lncRNAs (MALAT1, HOTAIR, and AFAP1‐AS1) and lymph node metastasis (LNM) of lung cancer. Methods Cell Press, PubMed, SpringerLink, Web of Science, and Google Scholar were explored to perform the literature search. After screening 1862 articles, 66 English‐language articles were selected based on the inclusion and exclusion criteria. From those articles, 17 publications comprising 1622 lung cancer patients were chosen for statistical analyses as well as quality assessment tests. Results Forest plot analysis revealed that there was a significant difference in the incidence of LNM between the high and low MALAT1 expression groups (OR = 3.21, 95% CI: 1.34–7.67; random effects model). Significant differences were also observed in the incidence of LNM between patients with high and low HOTAIR expression levels (OR = 4.17, 95% CI: 1.47–11.82; random effects model). The expression level of AFAP1‐AS1 was found to be significantly associated with LNM in lung cancer (OR = 2.31, 95% CI: 1.39–3.85, random effects model). Additional analysis from GEPIA and GEO databases revealed that the expression levels of these lncRNAs vary according to the type of tumor tissue, organ of metastasis, and cancer stage. However, these databases show that the result for AFAP1‐AS1 is the most aligned with the meta‐analysis's findings. Furthermore, several quality assessment tests showed that the AFAP1‐AS1 studies are more reliable compared to the studies of other lncRNAs. Conclusion This study suggested that LNM in lung cancer patients is associated mostly with an elevated AFAP1‐AS1 lncRNA level among the pool of three lncRNAs analyzed. Before these results can be implemented in a clinical setting, it is essential to conduct further validation and undertake comprehensive analysis to ensure robustness and reliability.