jimnoneill/paper-to-field-training huggingface dataset:
Limb remote ischemic preconditioning on lung protection in patients with thoracoscopic lobectomy: a randomized controlled trial

Field: Medicine (Health Sciences)

Abstract Background One-lung ventilation (OLV) is often used during lobectomy anesthesia. Inflammation and oxidative stress during OLV can aggravate lung tissue injury, which is an important factor causing postoperative acute lung injury. Studies have confirmed that remote ischemic preconditioning (RIPC) can initiate endogenous protective mechanisms and alleviate injury to target organs. However, whether RIPC has a lung protective effect in patients undergoing lung resection remains unknown. Therefore, this randomized controlled clinical study investigated whether RIPC could reduce OLV-related lung injury, improve intraoperative oxygenation parameters, and induce lung protection in patients with thoracoscopic lobectomy. Methods We adopted a single-center, randomized, single-blind clinical controlled trial method and selected 54 patients who underwent inferior lobectomy with OLV and were randomly divided into a preconditioning group (RIPC group) and a blank control group (NC group). The preconditioning group received lower limb RIPC before OLV, while the blank NC group did not receive RIPC. RIPC was used to perform 5 cycles of 5 min ischemia /5 min reperfusion on the opposite lower limb via a limb ischemia preadaptor. Four time points after anesthesia induction (T0), 30 min after single-lung ventilation (T1), 90 min after single-lung ventilation (T2), and 30 min after double-lung ventilation restoration (T3) were used as the data-recording and blood-collection points. The main outcome measure was the oxygenation index (OI), while the secondary outcome measures included Clara cell secreted protein CC16, inflammatory cytokines (IL-6), serum malondialdehyde (MDA), lung-related variables, and length of hospital stay. Results There was no significant difference in the OI in the RIPC group compared with the NC group at each time point of T0-T3 ( P > 0.05), but in general, the OI value of of the RIPC group at the T1-T3 time points showed an increasing trend compared with that of the NC group. There were significant differences in plasma CC16 levels between T1-T3 ( P < 0.05), and the plasma CC16 level in the RIPC group was significantly decreased. IL-6 and MDA levels at T1-T3 were lower than those in the NC group ( P < 0.05). However, there were no significant differences in blood pH and pulmonary-related variables (respiratory index (RI), alveolar-arterial oxygen partial pressure (A-aDO2), and arterial-alveolar oxygen partial pressure (a/A ratio)) ( P > 0.05), and the length of hospital stay was not significantly different ( P > 0.05). Conclusions Remote limb ischemic preconditioning can reduce lung injury during lobectomy and can protect lung tissue mainly by reducing the inflammatory and oxidative-stress responses.
My peers have also been an inspiration for me: developing online learning opportunities to support teacher engagement with inclusive pedagogy for students with severe/profound intellectual developmental disabilities

Field: Social Sciences (Social Sciences)

This article explores how an online course was received by a group of teachers who teach students with severe/profound intellectual developmental disabilities. The intent of the course was to engage teachers in conversations, activities and reflections that support the development of curriculum and instruction in a least restrictive environment. Twelve teachers enrolled in the course and 10 teachers completed an open‐ended survey about different aspects of the course design. The results of the surveys are discussed in the light of research on effective teacher learning in special education. The article illustrates that through careful course design, teachers can be supported to explore new ideas and be helped to apply new learning to the context of their classrooms.
Shape representation in computer vision

Field: Computer Science (Physical Sciences)

The recognition ability of a computer vision system is critically dependent upon the quality of its internal representations for the objects it wishes to recognize. In this dissertation the problem of designing a suitable internal representation for three-dimensional(3D) objects is addressed and one of our major goals is to refocus attention upon surface-based representations. In support of this goal a particular surface-based representation is presented and it is compared with existing volume-based representations. It compares favorably with respect to certain demanding criteria--scope and uniqueness, stability and sensitivity, and accessibility.
In our representation 3D objects are described by structured collections of surface patches and each primitive patch is described in the interpolative patch form first introduced by the late S. A. Coons. Boundary curves and blending functions are represented by cubic B-spline curves and these curves, in turn, are represented by their defining vertex polygons. Some of the nice properties of this representation include (1)broad scope--the ability to represent both polyhedral and curved objects, (2)direct computation of many gestalt shape features, (3)shape classification on both structural and intrinsic features, and (4) economy of storage.
The major part of this thesis is devoted to description of our surface-based representation and analysis of its properties. Several examples of objects described in this representation are presented and these objects are analyzed with respect to the gestalt shape features which are introduced. Some effort is devoted to the problem of extracting shape descriptions from 2D images and an algorithm for curve fitting 2D cubic B-splines to 4-connected digital curves is presented. Finally, the impact of our representation on matching techniques is explored in the context of 2D scene analysis.
Imaging of Lenticulostriate Arteries and Pontine Arteries using 5.0-Tesla Magnetic Resonance Angiography

Field: Medicine (Health Sciences)

Small arteries and arterioles, particularly the lenticulostriate arteries (LSAs) and pontine arteries (PAs) are known to be involved in small vessel disease, which contribute to progressive cognitive impairment in elderly persons. In this study, ultra-high field (5T) TOF-MRA was optimized and performed to visualize the LSAs and PAs. Our results show that 0.4mm3 is the optimal resolution for the visualization of LSAs and PAs.
From Secret Garden to Reign of Terror? the Regulation of State Schools in England

Field: Social Sciences (Social Sciences)

Abstract Explores the complex institutional jungle of regulators involved in regulating state schools in England. In this sector, in contrast with the prisons sector, regulators were able to link their monitoring to sanctions as drastic as closing schools down. The study found no clear evidence of the benefits of the enhanced regulatory regime in terms of examination performance (the main performance indicator set by government for schools).
Current Transformations in Turkish Education Policies in the Context of Global Agendas and Increasing Interaction in Education

Field: Social Sciences (Social Sciences)

Since the 2000s, Türkiye has taken important steps toward improving the quality of education in line with global goals and supported this concretely by putting forth a perspective on economic, social, and conjunctural developments both in the world and in the country in its top policies. Development plans emphasize global concepts such as the power of human resources, innovation, technology, and international cooperation in the successful continuation of the country's economic and social development. Education constitutes an important dimension of Türkiye's inclusive and sustainable growth targets and has been addressed in recent years with a holistic approach. Indeed, all targets for increasing participation in education before and after basic education have addressed the issue of access to education in a global context in the 11th Development Plan and the 2023 Education Vision Document. This chapter will evaluate the prominent activities in Türkiye in the areas of early childhood, vocational, and technical education, as well as teachers' professional development. Access to early childhood education has been the focus of this policy for most of the last decade, with a number of measures having been taken in recent years. The 2023 Education Vision and the high targets set for vocational and technical education take into account global trends within the framework of the country's needs, such as training qualified manpower; improving educational environments, human resources, and curricula; and ensuring the relationship among education, employment, and production. By recognizing that improving the quality of education largely depends on the professional development of teachers, an important step that has been taken recently in this regard is the recognition of teaching as a career profession through the Professional Development Law enacted in 2022.
Cucurbitacin IIb attenuates cancer cachexia induced skeletal muscle atrophy by regulating the IL‐6/STAT3/FoxO signaling pathway

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract The main features of cancer cachexia include skeletal muscle atrophy, which can significantly reduce the quality of life of patients. Clinical treatment of cancer cachexia is mainly based on nutritional therapy and physical exercise; medication only improves appetite but does not reverse the symptoms of skeletal muscle wasting. In this work, we systematically studied the underlying molecular mechanisms by which cucurbitacin IIb (CuIIb) ameliorates muscle wasting in cancer cachexia both in vitro and in vivo. CuIIb significantly ameliorated the chief features of cancer cachexia in vivo, alleviating weight loss, food intake, muscle wasting, adipose tissue depletion, and organ weight reductions. In vitro, CuIIb (10 and 20 μM) dose‐dependently attenuated conditioned medium (CM)‐induced C2C12 myotube atrophy. Collectively, our findings demonstrated that CuIIb prevented the upregulation of the E3 ubiquitin ligase muscle atrophy Fbox protein (MAFbx), myosin heavy chain (MyHC), and myogenin (MyoG) and impacted protein synthesis and degradation. In addition, CuIIb decreased the phosphorylation of Tyr705 in STAT3 by regulating the IL‐6/STAT3/FoxO pathway to reduce skeletal muscle atrophy in cancer cachexia.
PP101 Development Process Of The Economic Guidelines In Tunisia

Field: Health Professions (Health Sciences)

Introduction Health technology assessment (HTA) has become a critical support to health policy decision-making. The HTA evaluation process requires transparency, formalized processes, clear timelines, and standardization according to international best practice. Tunisia is establishing an HTA-based decision-making system through the National Authority for Accreditation and Assessment in Healthcare (INEAS) to ensure impartiality and fairness in decision-making, which is important for an emerging democracy. INEAS opted for a participatory approach in developing the national health economic guidelines to better engage healthcare sector stakeholders in the HTA process. We aimed to present the main phases of the process used to develop the Tunisian health economic guidelines, the methodological choices for pharmacoeconomic evaluations, and the methodological choices for budget impact analyses. Methods The different phases of developing the guidelines were listed and reported. Results The guidelines were developed under a technical cooperation program of the World Health Organization and involved collaboration between the Institut national d’excellence en santé et en services sociaux (INESSS in Quebec, Canada) and INEAS. The first version of the guidelines was drafted following a review of international HTA guidelines and best practice reference books, taking into account the Tunisian healthcare system context. This first draft was discussed in a workshop with the main health system stakeholders and then peer reviewed by international experts. Based on the feedback from experts, a second version was prepared and published on the INEAS website for public consultation. The Union of Innovative Pharmaceutical Research Companies (SEPHIRE), the National Health Insurance Fund (CNAM), and healthcare professionals provided the majority of feedback. The comments provided by SEPHIRE were discussed during a second workshop. The guidelines were revised and updated based on the comments provided and the final version was published in November 2021. Conclusions INEAS adopted a participatory approach for developing its economic guidelines, which enhanced engagement of the major health system stakeholders in the HTA implementation process in Tunisia.
Landscaping the Learning Environment to Create a Home for the Complex Mind

Field: Social Sciences (Social Sciences)

I am going to use the opportunity presented by the 2001 David Kinsey lecture to bring together some ideas expressed in m recent work and to reflect on my decades-long experience in creating the conditions for the development of learning in an international context. That experience, and my reflections on it, has led me to recognize that learning is an immensely more complex phenomenon than most of our current practice to promote and facilitate it would have us believe. Consequently, I have come to the conclusion that the complex human mind is poorly at home in much of the environment supposedly created to nurture it. Neglect of the essential conditions for its sustenance and growth has led the mind to lose its natural habitat, putting it at risk of becoming extinct. My emphasis will therefore be on what should be done to landscape the learning environment in such a way that the complex mind can find a home in it. I shall develop my ideas and raise questions about this issue, while calling attention to a number of key concepts.
Granulomatous slack skin - seven years follow-up of a case with features of "parapsoriasis en plaques", muscle involvement, granulomatous vasculitis, and necrobiotic changes.

Field: Medicine (Health Sciences)

Granulomatous slack skin (GSS) represents an extremely rare variant of mycosis fungoides with only 70 cases reported in the literature to date. It is characterized clinically by the occurrence of bulky, pendulous skinfolds, usually located in flexural areas and histologically by an infiltrate composed of small neoplastic T-lymphocytes joined by granulomatous inflammation with scattered multinucleated giant cells containing nuclei arranged in a wreath-like fashion. Since its first description, very rare cases of GSS with muscle involvement, large vessels involvement, or necrobiotic changes have been reported. We present an extraordinary case of GSS with all these unusual features developing in the lesions of the same patient. The long follow-up of seven years allowed us to document the evolution of each lesion. Some lesions appeared and evolved in a manner very reminiscent of those of "parapsoriasis en plaques", others were classical GSS lesions, and still others developed large ulcerated lesions. These ulcerated lesions consistently failed to respond to conventional wound therapy, skin directed therapy [retinoids + psoralen combined with ultraviolet A (PUVA)-therapy], and interferon-alpha therapy. Remarkably, the ulcers completely healed when systemic corticosteroids were added. We hence postulate that the ulcers appeared because of large vessel vasculitis rather than tumoral direct destruction.
Typing Tips, Copy/Paste, and Search

Field: Computer Science (Physical Sciences)

In this chapter, we will show you some good ways to type and save valuable time typing on your iPad, whether you use the Portrait (vertical/smaller) keyboard or the Landscape (horizontal/larger) keyboard. We will show you how to select different language keyboards, how to type symbols, and other tips. We will also show you some tips and tricks when working with various external keyboard accessories for your iPad.KeywordsUppercase LetterCorrect WordVirtual KeyboardEntire ScreenHome ScreenThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Effects of Antianginal Drugs on Human Platelet Function

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Journal Article Effects of Antianginal Drugs on Human Platelet Function Get access S. Chierchia, S. Chierchia Cardiovascular Unit,Hammersmith Hospital, and Institute of Clinical PhysiologyPisa,Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Crea, F. Crea Cardiovascular Unit,Hammersmith Hospital, and Institute of Clinical PhysiologyPisa,Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar R. DeCaterina, R. DeCaterina Cardiovascular Unit,Hammersmith Hospital, and Institute of Clinical PhysiologyPisa,Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar W. Bernini W. Bernini Cardiovascular Unit,Hammersmith Hospital, and Institute of Clinical PhysiologyPisa,Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar European Heart Journal, Volume 4, Issue suppl_B, April 1983, Page 11, https://doi.org/10.1093/eurheartj/4.suppl_B.11-b Published: 01 April 1983
Interactive Impacts of Rice Water Weevil1 and Sheath Blight Pathogen on Rice Yield

Field: Agricultural and Biological Sciences (Life Sciences)

In the southern US, rice, Oryza sativa L., is frequently attacked simultaneously by rice water weevil, Lissorhoptrus oryzophilus Kuschel, and sheath blight pathogen, Rhizoctonia solani J.G. Kühn. Field studies were used to determine the impact of L. oryzophilus infestation on development of sheath blight and combined effects of both L. oryzophilus and R. solani on yield of rice cultivars, ‘Cocodrie’ and ‘Jefferson’. Infestation by L. oryzophilus had no influence on severity of sheath blight in either Cocodrie or Jefferson. Grain yield of both cultivars was significantly less in response to infestation by L. oryzophilus. Infection by R. solani alone significantly reduced yield only in the susceptible cultivar Cocodrie. Percent yield losses in Cococdrie in response to exposure to L. oryzophilus and R. solani alone and in combination were 5.6, 23.9, and 20.0%, respectively. Similarly, percent yield losses in Jefferson in response to exposure to L. oryzophilus and R. solani alone and in combination were 7.3, 10.6, and 5.4%, respectively. Combined impact of infestation by L. oryzophilus and infection by R. solani on yield did not differ significantly from the impact of pathogen infection alone in Cocodrie. The combined impact of R. solani and L. oryzophilus on yield in Jefferson did not vary significantly from the impact of either alone. Results suggested that L. oryzophilus did not affect severity of sheath blight in rice, and the combined impact of L. oryzophilus and R. solani on rice yield was less than additive. Understanding the interaction between L. oryzophilus and R. solani, important pests of rice in the southern US, will help manage these pests more effectively.
Construct-related Validity of the Preschool Sound Production Test in Indonesian-Speaking

Field: Health Professions (Health Sciences)

The availability of a speech intelligibility test that is in accordance with Indonesian with good psychometric evidence is needed for clinical practice needs. This study aims to evaluation whether the Tes Produksi Bunyi Prasekolah (Preschool Sound Production Test) has evidence of construct validity. Seventy-eight preschool children were divided into three groups. Typical Groups I and II were children without speech sound disorder who lived in Jakarta and Padang. Group III was children with speech sound disorder. Participants in each group consisted of 26 children. Ten participants were 4 years old and 5 years old, and 6 participants were 6 years old for each group. Speech intelligibility, percentage of consonants correct, and percentage of vowels correct were assessed individually using the Preschool Speech Sound Production Test. Based on the analysis results, it was found that the speech intelligibility index in the SSD group was lower than in Typical Group I (MD = -43.9; p < .001) and Typical Group II (MD = -41.96; p < .001). Referring to the results obtained, it can be concluded that the Preschool Sound Production Test has construct validity.
Insertion of Internal Alkynes and Ethene into Permethylated Singly Tucked-in Titanocene

Field: Chemistry (Physical Sciences)

The singly tucked-in permethyltitanocene 1 reacts with an excess of internal alkynes to give the 1:1 adducts 3a−c,f−i, arising from insertion of the alkyne triple bond into the titanium−methylene bond. Only the simplest species, 2-butyne, inserted two molecules to give the known compound 2; however, at a 1:1 stoichiometric ratio the 1:1 adduct 3j was also smoothly formed. 1,4-Disubstituted conjugated diynes with CMe3 or SiMe3 substituents reacted in the same way by only one triple bond to give 3d,e, respectively. The dimethylsilylene-bridged dialkynes Me2Si(C≡CR)2 (R = SiMe3, CMe3) afforded compounds 3k,l with both triple bonds reacting. After insertion of the first triple bond, the second one underwent a rearrangement which resulted in substituent shift and formation of a silacyclobutene ring linked to the titanium atom. Alkynes bearing the bulky substituents CMe3 and SiMe3 were unreactive. Among a number of olefins and 1,3-butadiene, only ethene reacted to give cleanly the 1:1 adduct 3m. The structures of the paramagnetic [TiIII(η5-C5Me5){η5:η1-C5Me4(CH2CR1═CR2)}] products 3a−g,k,l were determined by single-crystal X-ray diffraction analysis. These compounds and compounds 3h−j,m, whose crystal structures could not be determined, were chlorinated with PbCl2 to give the diamagnetic products [TiIVCl(η5-C5Me5){η5:η1-C5Me4(CH2CR1═CR2)}] (4a−j) and the corresponding chlorotitanocene derivatives 4k−m. The solution structures of 4a−m were determined by 1H and 13C NMR spectroscopy, and crystal structures for 4b,e,g,l,m were found by single crystal X-ray diffraction analysis. DFT calculations threw light on the transition-state molecule for the formation of 3j and revealed a steric hindrance to be responsible for preventing the insertion of a second molecule of hex-3-yne, the closest homologue of but-2-yne, to react with 3i, forming a homologue of 2.
Self-Harm and Aggression in Dangerous and Severely Personality Disordered Patients of a High-Security Hospital

Field: Psychology (Social Sciences)

This study examined the frequency, prevalence and co-occurrence of aggression and self-harm in patients admitted for assessment and treatment to a high-security dangerous severe personality disorder (DSPD) hospital. Results showed that most patients admitted to this unit were aggressive and many patients self-harmed during the period of study. Few patients were neither aggressive nor self-harming. Patients who self-harmed and behaved aggressively were typically aggressive before their first episode of self-harm, and the likelihood of self-harm seemed to increase during the later stages of their hospital stay. Possible explanations for these findings are offered.