jimnoneill/paper-to-field-training huggingface dataset:
Regulation of the Human FcεRI α-Chain Distal Promoter

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract The α-chain of the high affinity receptor for IgE (FcεRI) is essential for cell surface expression of FcεRI and binding of the IgE Ab. The human α-chain gene possesses two promoters: the proximal promoter, which is highly conserved with that of rodent; and the distal promoter, the structure and role of which are largely unknown. Transcriptional regulation of the α-chain distal promoter was investigated in this study. Transient reporter assay revealed critical region for transcription activity located within −27/−17. EMSA identified Elf-1, YY1, and PU.1 as transcription factors binding to this region. In contrast to the proximal promoter, which was trans-activated by YY1 and PU.1, these transcription factors exhibited repressive function on this promoter. Addition of IL-4 caused a marked increase in transcription from the distal promoter and subsequently increased the intracellular production of the α-chain. These results indicate that IL-4-dependent up-regulation of the human α-chain was due to enhancement of distal promoter activity and suggests that the two promoters have different regulatory mechanisms for α-chain expression.
A Qualified Entities Comment on Consumer Law Enforcement

Field: Social Sciences (Social Sciences)

Before the Volkswagen emission scandal occurred, never had the discussion about consumer law enforcement in mass harm cases been as lively but also as wide-ranging as it is currently. It does not only affect Germany or the EU. It seems as if all over the world legal experts query their legal systems. For decades, the work of consumer associations was more or less disregarded by law firms. Since the declaratory model action (Musterfeststellungsklage) entered into force, Germany has been assailed with a veritable contest for ‘customers’’. Advertising messages meant to convince the consumers concerned to assign their claims, to engage a specific lawyer or to resort to a third-party funder are in many cases questionable: advertisements promising 100 per cent reimbursement within a very short time and without any risk, press conferences calling consumers to leave the Musterfeststellungsklage as this would certainly take years before coming to a result. The whole truth is that nobody could know at that stage what the outcome of the Musterfeststellungsklage would be and when it would end.
CAENORHABDITIS ELEGANS AND ANGIOGENESIS

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract: Angiogenesis is sprouting of new capillaries from already existing ones. It is a dynamic process that can be seen in every phase of human life. It is among the dynamic mechanisms of both physiological and pathological processes. Vascular endothelial growth factor is one of the many molecules that play a role in angiogenesis. Vascular endothelial growth factor&amp;nbsp; is released specifically to the endothelium. It regulates mitogenesis, vascular tone, vascular permeability and vasodilatation in the vascular endothelium. Caenorhabditis elegans is a nematode used to detect and screen the developmental processes and genetic mutations. It is appropriate to study at the organism level to isolate cells and to demonstrate intercellular interactions in vivo. Polyvinyl fluoride-1 is a molecule that plays a role in the neural development of Caenorhabditis elegans. In addition, the polyvinyl fluoride-1 molecule is told to be effective in angiogenesis. Studies have shown that polyvinyl fluoride-1 binds to vascular endothelial growth factor receptor-1 and vascular endothelial growth factor receptor-2, but not to vascular endothelial growth factor receptor-3 and platelete derivated growth factor receptor β. In the research of human umbilical vein endothelial lines, it was observed that polyvinyl fluoride-1 induced angiogenesis and vascular tube formation. These results suggest that Caenorhabditis elegans may have a very important role in vascular endothelial growth factor studies. Caenorhabditis elegans model is used in many scientific areas such as aging, nervous system and genetic changes. However, only a few laboratories around the world studied the Caenorhabditis elegans angiogenesis model. Besides, this model is not currently used in Turkey. This provides a great advantage in terms of the utilization of this model in angiogenesis.&amp;nbsp;
Research on directed diffusion routing protocol in wireless sensor networks

Field: Computer Science (Physical Sciences)

In order to bring the potential advantages of directed diffusion routing into full play in wireless sensor networks, the traditional MHR protocol was improved, and the MLN protocol was presented. By decreasing the gradient level width of directed diffusion gradient field, the connectivity of network would be enhanced, so that the reliability of data aggregation would be improved. At the same time, by changing the data-packet forwarding rule of hop-by-hop in MHR networks to the rule of lowest-hop-forwarding in MLN networks, the real-time performance and energy efficiency of data aggregation would be improved on the premise of high data aggregating reliability. The theoretical analysis and simulation results validated that the MLN protocol would not only enhance the connectivity but also improve the comprehensive performances of the directed diffusion routing protocol greatly in wireless sensor networks.
Introduction

Field: Arts and Humanities (Social Sciences)

This introduction discusses the main themes of this volume by utilizing the interlocking moral concepts of decency and indecency to question religious discourse, understanding, and activism with marginalized people. “An Outrage Against Any Decent People” highlights that practitioners and faith-based specialists have more work to do to build healthy and respectful praxes with sex workers and sex trafficking survivors. Through contextual and theological analysis, this introduction points to ways the authors of this volume address these concerns.
Inter-Life: a novel, three-dimensional, virtual learning environment for life transition skills learning

Field: Social Sciences (Social Sciences)

This paper presents the findings from one of the first empirical research studies which has investigated the impact of Inter-Life; a novel three-dimensional immersive virtual learning environment, on learning and development of social and educational life transition skills in a group of looked after and accommodated children. Drawing on social constructivism in which meaningful learning is related to context and situated in practice, we report on a series of Inter-Life workshops that enabled young people to work together and through the processes of participation in authentic learning activities contributed to the development of life transition skills such as self-confidence, empathy, negotiation and mediation skills, teamwork and active problem-solving skills. The novel affordances of the Inter-Life virtual world which contributed to the development of the learning community included the ability to personalise learner engagement and activities from the outset along with ‘co-presence’ and ‘immersion’ and the flexibility provided by the innovative, technology-enhanced Inter-Life platform. This study presents some empirical evidence to demonstrate the efficacy of new models of learning that are mediated by innovative malleable technologies that can be shaped by the learner in a participatory manner.
[Mechanism of activation of the photosensitizing effect of water-soluble analogs of chlorophyll when bound to a polymer].

Field: Chemistry (Physical Sciences)

It has been shown that the order of mixture of photoreduction components of methylene red with ascorbic acid sensitized with clorine e in an aqueous solution of polyvinilpyrrolidone markedly affects the rate and depth of the reaction. The data obtained support the hypothesis that the intensificiation of the sensitized reaction in the presence of polymer is conditioned by joint polymer binding of the reaction components. This binding facilitates the interaction between the electron donor or acceptor with the light-excited pigment.
The Ilizarov Method

Field: Health Professions (Health Sciences)

To the Editor: I am delighted to see an article such as “The Ilizarov Procedure: Limb Lengthening and Its Implications” by Simard and colleagues ( Phys Ther . 1992;72:25–34) being published in the physical therapy literature! Limb lengthening by gradual incremental distraction methods (eg, the Ilizarov method) requires intensive intervention by our profession to ensure acceptable results, and overall there has been inadequate education provided to most physical therapists treating these patients. This article should definitely be included in any list of references provided to therapists who are new to the area of limb lengthening.

From my experience in researching the use of the Ilizarov limb-lengthening procedure in these patients, I have noticed a few areas in need of further clarification. Tajana et al1 were not the first to report research in the area of the Ilizarov method of distraction osteogenesis in humans.…

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[1]: /lookup/volpage/72/25?iss=1
Vortex Swarm Path Planning Algorithm

Field: Computer Science (Physical Sciences)

This paper presents an algorithm for trajectory planing using potential fields and swarms with vortex behavior. This algorithm is called Vortex Swarm Path Planning Algorithm (VSPP). There are several methods for trajectory planning in robotics, the most popular is the one based on artificial potential fields. However this method has the disadvantage of local minima which can make the robot fail when reaching the destination point. The proposed algorithm here presented employs a model of active Brownian particles with vortex behavior that allows the trajectory planning evading local minima.
Genetic variability, character associaton and path analysis in the tamarind (Tamarindus indica L.) population of Nallur tamarind grove

Field: Agricultural and Biological Sciences (Life Sciences)

An experiment was carried out during 2009-2010 on one hundred tamarind genotypes of the Nallur tamarind grove, a few kilometres away from Bengaluru International Airport, to investigate the genetic variability, character association and their direct and indirect effects on the fruit weight of tamarind. The genotypic coefficient of variation was high for seed weight, fibre weight, seed number, beak length and fruit weight. In all cases, phenotypic variances were higher than the genotypic variance. Moderate to high heritability as well as genetic advances were estimated for pod length, pod width, seed weight, seed number, number of ridges, number of furrows, pulp weight and fruit weight indicated that these traits was under additive gene control and selection for genetic improvement for these traits would be effective. Correlation studies revealed the highest significant association of fruit weight with seed weight followed by pulp weight, epicarp weight and seed number at genotypic and phenotypic level. Positive direct effects were produced by pulp weight and seed weight, while number of ridges had negative direct effects. The information obtained from the current studies can be used as selection criteria for genetic improvement of tamarind genotypes under study. DOI: http://dx.doi.org/10.3329/sja.v12i1.21109 SAARC J. Agri., 12(1): 20-25 (2014)
Are You Getting Enough to Eat? Addressing Food Insecurity in Rehabilitation Clients

Field: Health Professions (Health Sciences)

Food insecurity is a well-known risk factor for poor health and quality-of-life outcomes. Recent explorations of census data have concluded that it is experienced disproportionately by individuals with disabilities, making it an important area of focus for rehabilitation counseling and research. The purpose of this study is to explore the relationship between food insecurity and work barriers and intrapersonal characteristics that are often the focus of rehabilitation counseling. Findings from a national sample of adults with disabilities ( N = 435) reveal that individuals with less than a bachelor’s degree or in a household earning less than $40,000 per year were more likely to report high food insecurity. In addition, food insecurity correlated with unfavorable outcomes in measures of self-reported health, depression, social support, acceptance of chronic illness and disability (CID), and vocational self-efficacy. Implications are presented for increasing attention to the issue of food insecurity within the context of rehabilitation counseling practice and research, including strategies for augmenting services to include food assistance in a way that is sensitive to the experience of individuals with significant resource gaps.
240 Habitual Sleep Changes Following COVID-19 Outbreak

Field: Medicine (Health Sciences)

Abstract Introduction The ongoing COVID-19 pandemic emerges as one of the most impressive and strenuous events of the century, with unthinkably huge global effects. We aimed at analyzing if and how does the pandemic affect sleep and related behaviors. Methods We reviewed 48,047 nights recorded in the US with the Sleeprate application by 3,381 users during a period of 2 years, December 2018-November 2020. Nightly data included perceived and measured sleep parameters. In addition, users reported their perceived daytime stress and sleepiness. We analyzed the monthly variability of the studied parameters and compared their values during the COVID-19 period of March-November 2020 (CP) with those in the previous corresponding period in 2019, the pre-COVID-19 period (PCP). Results Starting March 2020, wake-up time (WUT) was significantly delayed relative to PCP. WUT in April 2020 was the latest (8:06AM±2:12hours, mean±SD, p&lt;.000), being an hour later than in April 2019. This delay started to diminish in June 2020, reaching 7:27AM±2:10 hours by November 2020, which was not significantly higher than during PCP. Bedtime (BT) exhibited similar behavior, yet it returned to PCP times faster. Delayed BT and WUT on weekends were observed during CP as well as PCP. No consistent differences in sleep duration or sleep efficiency were detected between CP and PCP. Subjective sleep satisfaction was higher in CP relative to PCP. However, daytime sleepiness and daytime stress were also higher during most of CP compared to PCP. Conclusion Our data, based on digital in-app sleep diaries coupled with perceived sleep parameters, demonstrate the pandemic’s effects on sleep behavior in the US. Users in this study adapted to the new circumstances with delayed sleep schedule, while not reducing the sleep opportunity. The higher sleep satisfaction may be connected to later sleep schedules, allowing a wake-up time that fits better human biological clocks. The reported increased stress and sleepiness further portray the uncertainty and turbulence characterizing the pandemic’s effects on populations life during the pandemic. As good sleep is linked with immune response efficacy, higher quality of life, and improved mood, the importance of sleep must not be overlooked, especially during the pandemic. Support (if any):
A 52-year-old man with heartburn and weight loss

Field: Medicine (Health Sciences)

A previously fit and well 52-year-old man presented to the hospital with a 3-month history of refractory heartburn and progressive weight loss (5 kg). After an initial response to empiric treatment with 20 mg omeprazole daily, heartburn relapsed and became refractory to proton pump inhibitor. His past medical history and physical examination were unremarkable. Upper endoscopy showed a thick white membrane in the distal part of the oesophagus, crossing the gastro-oesophageal junction (figure 1A); the mucosa surrounding the distal margin was slightly depressed but not reddened. An initial diagnosis of candidosis was suggested and …
Draft genome sequence of glyphosate-degrading Ochrobactrum sp. strain GPK 3 (VKM B-2554D) isolated from agricultural soil

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ABSTRACT The genome of Ochrobactrum sp. isolated from agricultural soil polluted with the herbicide glyphosate is reported. The genome size is 5.48 Mb with an average G + C content of 56.3%. This genomic data could contribute to a better understanding of biochemistry and regulatory mechanisms of microbial degradation of glyphosate and 2-aminoethylphosphonic acid
Older people’s perceptions of the impact of Dance for Health sessions in an acute hospital setting: a qualitative study

Field: Health Professions (Health Sciences)

Objectives To explore the perceptions of hospitalised older people and their relatives of the impact of taking part in group dance sessions in an acute hospital setting. Design A qualitative descriptive approach was used. Setting An acute hospital trust in the East of England. Participants Purposive sample of dance group participants. Intervention Weekly music and movement sessions for frail older people on Department of Elderly Medicine Wards and the Stroke Rehabilitation Unit. Sessions take place in the ward and are facilitated by a dance artist supported by ward staff. Results Twenty-one semistructured interviews were conducted with older people and/or their relatives. Thematic analysis of the data identified three overarching themes: (1) dance as a physical activity, (2) dance as an opportunity for social interaction and (3) the dance group as a source of emotional support. Sessions were valued as an enjoyable way to undertake physical activity and provided an opportunity for social interaction between patients. This is important as loneliness and boredom are a common occurrence during hospitalisation and are detrimental to overall health and well-being. Patients reported an emotional impact though taking part; happiness from engaging with the group and the release of pent up emotions through the triggering of memories by the music and conversations within the group. Conclusion Dance for Health provides a range of physical, social and emotional benefits for hospitalised older people. Further research is required to investigate the effectiveness of group dance sessions in increasing physical activity on an acute ward and the potential psychological benefits for hospitalised older people.
Experimental and Numerical Studies of Thermally Induced Acoustic Waves in an Enclosure

Field: Physics and Astronomy (Physical Sciences)

The behaviors of thermally induced acoustic waves generated by the rapid heating of a bounding solid wall in a closed cylindrical tube are investigated experimentally. The induced flow and pressure fields due to rapid heating are also numerically simulated. In the experiments, a resistance-capacitance circuit is used to generate a rapid temperature increase in a thin nickel foil located at one end of the closed cylindrical tube. The thermally generated pressure (acoustic) waves undergo repeated reflections at the two ends of the tube and gradually decay. The time-dependent pressure variation in the tube and the voltage and temperature histories at the foil are recorded by a fast-response measurement system. The characteristics of the generation, propagation, and decay of the acoustic waves are measured by two different transducers (Bruel & Kjaer model 4193 and Endevco model 8507C-1). To simulate the experiments numerically, the compressible unsteady axisymmetric Navier-Stokes equations are solved by a highly accurate algorithm. Both the experimental and numerical studies predict similar pressure wave shapes and profiles. The measured decay rate of the acoustic waves is found to be somewhat faster than the numerically predicted rate.
Ag, Au and ZrO2@reduced graphene oxide nanocomposites; Pd free catalysis of suzuki-miyaura coupling reactions

Field: Chemistry (Physical Sciences)

Abstract Suzuki coupling is a widely used, well-studied and versatile method in synthetic chemistry for development of C–C bonds where palladium-based catalysts have been used extensively in the reaction to date. We report a Suzuki-cross-coupling reaction for C–C bonds formation between aryl halides and phenylboronic acid by using Metal/metal oxide@Reduced graphene oxide nanocomposites being efficient, simple and cost-effective. In this work, plant mediated synthesis of silver, gold and zirconia nanoparticles doped Reduced Graphene Oxide nanocomposites is reported where 30 mg of each of the catalysts resulted in C-C bond formation achieving percentage yield comparable to palladium-based catalyst used as standard in series of reactions, attaining highest yield with silver based catalyst. The catalysts demonstrated high catalytic activity over three cycles of recycling with no loss. Bromoaryl and phenylboronic acid are coupled together by the increased surface area of the reduced graphene oxide substrate, which also exhibits enhanced reactivity toward other chemical reactions. XRD, FTIR and UV–vis analyses were used to describe the synthesized catalyst. Using the devised technique, various substituted aryl halides have been used successfully with modest to high yields of the desired biphenyls.
A Multi Constrained Path Quality of Service Routing Algorithm

Field: Computer Science (Physical Sciences)

Providing Quality-of-Service (QoS) in packet switched networks has many challenging problems. One of the m is how to determine a feasible path that satisfies additive multiple constraints. A difficulty of multi constrained path problem is that it is intractable. In this context Multi Constraint path Problem version 3 (MCPv3) is presented where all constraints are approximated and return a feasible path in much quicker time. This problem is modeled by using a graph with K additive QoS constraints associated with each edge for any constant K≥2.MCpv3 is an approximation algorithm that finds a path between a given source and destination pair such that the path weight is not more than (1+α)W where α is approximation factor and W is constraint bound. By properly selecting α and constraint bounds MCPv3 performs well in terms of better quality of paths, less running time and improved scalability irrespective of nature of constraints. A variety of experimental validations are carried out on different scenario to analyze the performance of the proposed schemes.