jimnoneill/paper-to-field-training huggingface dataset:
Age‐dependent expression of duodenal cytochrome b divalent metal transporter 1, ferroportin 1, and hephaestin in the duodenum of rats

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Background and Aim The body's requirement for iron is different at different developmental stages. However, the molecular mechanisms of age‐dependent iron metabolism are poorly understood. In the present study, we investigated the expression of iron transport proteins in the duodenum of S prague– D awley rats at five different age stages. Methods Male S prague– D awley rats at postnatal week ( PNW ) 1, 3, 12, 44, and 88 were employed in the study. Serum iron status and tissue non‐heme iron concentrations in the spleen, liver, bone marrow, heart, kidney, duodenal epithelium, and gastrocnemius were examined at each age stage. The expression of duodenal cytochrome b ( D cyt B ), divalent metal transporter 1 ( DMT 1), ferroportin 1 ( FPN 1), hephaestin, and hepcidin were measured by real‐time polymerase chain reaction or W estern blot. Results The levels of serum iron and transferrin saturation were higher in the rats at PNW 1 and 3 than in those at PNW 12, 44, and 88. Non‐heme iron contents decreased from PNW 1 to PNW 3 and then increased thereafter. Duodenal D cyt B , DMT 1, and FPN 1 increased to the highest level at PNW 3 and then decreased from PNW 12 to 88. The hepatic hepcidin m RNA level decreased to the lowest level at PNW 3 and then increased with age. Conclusion Our findings showed that age had a significant effect on body iron status. The increased duodenal D cyt B , DMT 1, and FPN 1 expression can enhance intestinal iron absorption to meet the high iron requirements in infants. Hepcidin or enterocyte iron levels may be involved in the regulation of age‐dependent FPN 1, DMT 1, and D cyt B expression in the duodenum.
Growth and spoilage metabolites production of a mesophilic Aeromonas salmonicida strain in Atlantic salmon ( Salmo salar L.) during cold storage in modified atmosphere

Field: Agricultural and Biological Sciences (Life Sciences)

Little information is available on the spoilage potential of Aeromonas spp. in minimally processed salmon products under different packaging conditions. The study clearly demonstrates the importance of hurdle technology and provides data to further elucidate the significance of Aeromonas spp. as a spoilage organism.
Airflow Effects on Fires. Part II.

Field: Engineering (Physical Sciences)

This report expands the knowledge of airflow effects on fuel fires initiated by nonnuclear combat damage obtained from previous work reported in JTCG/AS-T-75-001. An investigation is made into the influence of selected airflow parameters (coefficient of pressure and the bonudary layer thickness) upon the blowout velocity for a variety of damage conditions and angles-of-attack. (Author)
The research and application of vehicle comfortableness based on analytic hierarchy process method

Field: Decision Sciences (Social Sciences)

In this paper, we evaluate the cabin system of human-vehicle-environment of contain vehicle aggregately based on analytic hierarchy process method. And then detail the evaluation methods, principles and processes. The analysis of the vehicle comfortableness can improve the driving safety, guarantee the driver security and reduce the wrong operation effectively. We first state the aim and meaning of the vehicle comfortableness analysis. Then, we analyze the factors may affect the comfortableness. After that, we build the cabin system of human-vehicle-environment and finally establish the analysis contents and proposal. Based on the national and industry standards, we put forward the subjective and objective evaluation of display class, control class, vehicle class and environment class. Meanwhile, we design the evaluation system of cabin system of human-vehicle-environment. Using the analytic hierarchy process method, we evaluate the cabin system of driver-vehicle-environment of contain vehicle aggregately and calculate the weight value of all the factors of this system. Then, we get the quantitative evaluation result and provide improvement method for the traditional design.
Dynamic Recrystallization Behavior of Ti22Al25Nb Alloy during Hot Isothermal Deformation

Field: Materials Science (Physical Sciences)

Abstract Dynamic recrystallization (DRX) of Ti22Al25Nb alloy has been investigated based on the analysis of hot compression experimental data in this paper. The true stress–strain curves of Ti22Al25Nb can be divided into two types: the single-peak conventional dynamic recrystallization (CDRX) curves and the multi-peak discontinuous dynamic recrystallization (DDRX) curves. The multi-peak curves indicate the alternate dominance of hardening mechanism and softening mechanism. A critical Zener–Hollomon parameter ln Z C has been proposed to divide CDRX from DDRX. The hardening rate and DRX volume fraction of CDRX and DDRX have been analyzed. In addition, the effect of the second-phase particle on the DRX has been studied. DRX process was enhanced by the second-phase particles, but the growth process of recrystallized grains was restrained.
Assessing the Diagnostic Potential of Hemoglobin-Platelet and Lymphocyte- Monocyte Ratios for Colorectal Cancer

Field: Medicine (Health Sciences)

Abstract

Background Colorectal cancer ranks as the third most diagnosed and second most lethal cancer globally. The challenge of early detection, essential for better outcomes, lies in the often non-specific or absent early symptoms, resulting in low diagnosis rates, particularly in resource-limited settings. For the first time, This study pioneers the evaluation of the diagnostic utility of hematological parameters, specifically the lymphocyte-monocyte ratio (LMR) and the hemoglobin-platelet ratio (HPR), in pre-operative CRC patients in Ghana. Method This unmatched case control study recruited 50 CRC patients pathologically diagnosed colorectal cancer and 50 healthy controls. Venous blood samples were collected for laboratory analyses using Beckmann780. All statistical analyses were performed using R Statistical Software (v4.3.2; R Core Team The receiver operating characteristic (ROC) curve and logistics regression model were used to assess the individual and combined diagnostic value of haematological parameters in detecting CRC at significance levels of p-value of < 0.05 and .95% confidence interval. Results The mean age of cases (55.92 years) was significantly higher than controls (37.92 years) (p < 0.0001). The clinical presentation of CRC patients wa mainlychanges in bowl (48.0%) and bleeding per rectum (42.0%). Colon cancer represented 58% of cases while rectal cancer represented 42%. Adenocarcinoma was the most common histologic type(100%). CRC patients had significantly lower levels of lymphocyte-monocyte ratio (p < 0.0001), haemoglobin-platelet ratio (p < 0.0001) and platelet-lymphocyte ratio (p < 0.05) compared to controls. At a cut-off of ≤ 0.068, HPR was the diagnostic marker for detecting CRC with high sensitivity of 81.6%, specificity of 98.0%, a positive predictive value of 97.6%, and a negative predictive value of 84.5% as well as area under the curve and accuracy of 91.6% and 89.9% respectively. HPR in combination with LMR (cOR: 3106682390.00, 95% CI: (0.00-inf); p = 0.9988) showed a significant increased chances of detecting CRC among study subjects. Conclusion The study identifies HPR as a potent standalone diagnostic marker for CRC and underscores its improved diagnostic efficacy when combined with LMR. This combination offers a cost-effective and accurate diagnostic tool for CRC, especially valuable in settings with limited resources.
Type I Interferon-Sensitive Recombinant Newcastle Disease Virus for Oncolytic Virotherapy

Field: Medicine (Health Sciences)

ABSTRACT Newcastle disease virus (NDV), an avian paramyxovirus, is tumor selective and intrinsically oncolytic because of its potent ability to induce apoptosis. Several studies have demonstrated that NDV is selectively cytotoxic to tumor cells but not normal cells due to defects in the interferon (IFN) antiviral responses of tumor cells. Many naturally occurring strains of NDV have an intact IFN-antagonistic function and can still replicate in normal human cells. To avoid potential toxicity issues with NDV, especially in cancer patients with immunosuppression, safe NDV-oncolytic vectors are needed. We compared the cell killing abilities of (i) a recombinant NDV (rNDV) strain, Beaudette C, containing an IFN-antagonistic, wild-type V protein (rBC), (ii) an isogenic recombinant virus with a mutant V protein (rBC-Edit virus) that induces increased IFN in infected cells and whose replication is restricted in normal human cells, and (iii) a recombinant LaSota virus with a virulent F protein cleavage site that is as interferon sensitive as rBC-Edit virus (LaSota V.F. virus). Our results indicated that the tumor-selective replication of rNDV is determined by the differential regulation of IFN-α and downstream antiviral genes induced by IFN-α, especially through the IRF-7 pathway. In a nude mouse model of human fibrosarcoma, we show that the IFN-sensitive NDV variants are as effective as IFN-resistant rBC virus in clearing the tumor burden. In addition, mice treated with rNDV exhibited no signs of toxicity to the viruses. These findings indicate that augmentation of innate immune responses by NDV results in selective oncolysis and offer a novel and safe virotherapy platform.
Children With Persistent Otitis Media: Audiometric and Tympanometric Findings

Field: Medicine (Health Sciences)

Audiometric and tympanometric findings were compared among 129 patients with clinically manifest persistent otitis media (OM) with effusion. Ears with thick effusion (mucoid OM) had significantly larger air-bone gaps and higher prevalence of flat tympanograms than either of the thin effusion types (purulent [POM] or serous OM [SOM]) or ears with no effusion (dry). Ears with thin effusion (POM and SOM) had similar air-bone gaps, thresholds for air and bone conduction, and prevalences of flat and underpressure tympanograms. Ears with no effusion had significantly smaller air-bone gaps, slightly poorer bone conduction thresholds, and lower prevalence of flat tympanograms than ears with effusion (MOM, POM and SOM). Ears with clinically manifest OM and no effusion at tympanocentesis appear to represent patients with a spontaneously resolved episode of OM with thin effusion (POM or SOM) or with ears that evacuated during anesthesia prior to tympanostomy.
Specification for Synthetic Surfaced Running Tracks

Field: Engineering (Physical Sciences)

This specification establishes the minimum performance requirements, classification, and test methods for synthetic surfaced running tracks. Even so, this specification does not imply that an injury cannot be incurred if the surface is found to be in compliance with this specification. The requirements for which newly installed synthetic surfaces shall be tested on and consequently comply to are imperfections, evenness, thickness, drainage, force reduction, modified vertical deformation, texture influence when wet, tensile properties, color in grey scale, weathering, spike resistance, and flammability.
Swift's Tale: On Satire, Negation, and the Uses of Irony

Field: Arts and Humanities (Social Sciences)

SWIFT TEASES US into thought. His satires, self-referential as they are, turn the mind inward on itself and, also, to the inner life of satire. Gulliver, the Modest Proposal, the Tale, all are deep allegorical versions of their own surface structures. It is the Tale that I am going to talk about here-and about some of its satiric effects that seem to me exemplary of the satiric case. Everyone agrees that satire resists definition, and the reason is usually supposed to be because family resemblances (after Wittgenstein we needn't insist on more) are fiendishly difficult to establish. Though there are by-blows in the best of families, the lineal mark is likely to be strong. Not so, we think, with satire. Even if we are well disposed to genre as a working concept, still so much is happening in satire--that is, in all the different things to which the label gets attached-that we protect ourselves with those reassuring quotation marks. But are there not some other reasons besides the inductive ones for our perplexity? If not, we are wrong to make such a fuss. The grass looks greener everywhere else. Why are we not so lucky, we think, as to be feeding in the rich, well-fenced pastures of (say) tragedy and comedy? Or, as is really the motive behind most such pseudoenvious glances, why does anybody bother with tragedy and comedy when, as matters for definition, they are such sybaritic fare? All this is the usual self-aggrandisement and consolation of the mind. But in rational moments we know that others are feeling equally put upon by circumstance. Is the insistence on the different-ness of satire just another case, then, of critical self-applause? Or is there really something to it? Introductions get written after the fact. It would not be wrong to call what follows an attempt to find out if critics of satire are suffering from mass delusion, but the description implies the outcome. I think
Hand Bookbinding: Materials, Methods, and Techniques as they Relate to Preservation and Conservation

Field: Arts and Humanities (Social Sciences)

This paper examines a range of materials, methods, and techniques used in contemporary Western hand bookbinding from a preservation and conservation perspective. While certain materials and techniques can produce a hand-bound book with a long expected life as a readable object, the range of available materials and extant binding styles, combined with the lack of any official standards for the craft, can result in objects that are less stable and less durable. A wide range of common binding materials and methods are discussed in terms of their contribution to the stability and usability of the finished object; the lack of agreement between expert hand bookbinders regarding best practices is also demonstrated. Standards that have been established for the purposes of library preservation and conservation, which are also relevant to hand bookbinding practices, are noted. This paper then discusses certain materials and methods used in bookbinding in East Asia, including some traditional methods that have begun to be incorporated into contemporary bookbinding and book arts. Finally, trends in hand bookbinding and book arts, as well as certain issues concerning the concept of the book-object and the debate between aesthetic value and usability, are explored.
Long-term non-pharmacological weight loss interventions for adults with type 2 diabetes mellitus

Field: Medicine (Health Sciences)

Weight loss strategies using dietary, physical activity, or behavioral interventions produced small between-group improvements in weight. These results were minimized by weight loss in the comparison group, however, and examination of individual study arms revealed that multicomponent interventions including very low calorie diets or low calorie diets may hold promise for achieving weight loss in adults with type 2 diabetes.
PREPARATION AND PROPERTIES OF AGGLOMERATED CORK PANELS BOUND WITH CHITOSAN BINDER

Field: Materials Science (Physical Sciences)

In this paper, acidified chitosan was used as an adhesive to prepare aldehyde-free, environmentally-friendly agglomerated cork panels by hot-pressing. After preparation, thephysical, mechanical, and the finishing properties of the chitosan-glued agglomerated cork panels were investigated. The optimal mass ratio of acetic acid solution (1wt.%) to chitosan was determined to be 30:1. The resulting hot-pressed agglomerated cork panels, which featured adensity of 0.55 g.cm-3and a thickness of 4 mm, exhibited a tensile strength of 1.70 MPa and athermal conductivity of 0.11W.m-1·K-1. The agglomerated cork panels coated with theoil-based polyurethane and water-based, acrylic-modified polyurethane paints exhibited significantly lower lightness and higher glossiness. The total color differences (ΔE*) ofboth agglomerated cork panels increased before and after finishing. The oil-based polyurethane paint coating exhibited high adhesion of paint film, reaching a level-0 adhesion, while thewater-based, acrylic-modified polyurethane paint coating achieved a level-1 adhesion. Theabrasion resistance results showed that the substrates of cork agglomerates coated two types of paint did not expose after undergoing abrasion for 100 revolutions atthe turntable speed of 60 rpm.
Characterization of some olive oil quality aspects by nirs analysis of its fatty acids and triglycerides

Field: Agricultural and Biological Sciences (Life Sciences)

The development of new rapid techniques to characterize aspects of the quality of olive oils is of great interest, specially when they do not depend on the use of solvents and reagents. Two main areas of application of these techniques are 1) determining the varietal origin and 2)\nolive oil authentication against fraudulent mixtures of plant oils. In this work we have developed predictive models based on spectroscopy Vis/NIR that allow analysis of the composition of fatty acids (FAMES) in olive oil and accurately estimating their triglyceride composition.\nStrategies for developing fraud detection techniques on olive oils, based on the Vis/NIR analysis of their triglycerides composition and 'Equivalent Number of Carbon' (ECN), are being studied.
Evaluasi Pelayanan Akademik pada Perguruan Tinggi Swasta Prodi Teknik Industri Menggunakan Metode IPA dan SERVQUAL

Field: Business, Management and Accounting (Social Sciences)

This study provides insights for improving academic service quality and enhancing student satisfaction. The Industrial Engineering Program aims to enhance academic service quality to support students’ success. Recent survey data indicate a decline in satisfaction, with a 9.11% drop from 2021/2022 to 2022/2023 (from an average score of 4.39 to 3.99) and a further 20.80% decline from 2022/2023 to 2023/2024 (down to 3.16). This study analyzes service quality using SERVQUAL and IPA methods across 22 service attributes to identify areas needing improvement. Results show all attributes with a negative gap, with the smallest gap in academic advising (P10) at -0.76, indicating it is closest to meeting student expectations. The IPA framework categorizes improvements into four quadrants, prioritizing restroom cleanliness, laboratory facilities, and classroom comfort (Quadrant 1). Suggestions include aligning service attributes more closely with student needs and exploring how service quality impacts academic performance and well-being. This research provides key insights to enhance service quality and student satisfaction in the future.
Ramipril improved walking times and QOL in peripheral artery disease and intermittent claudication

Field: Medicine (Health Sciences)

Source Citation THIS ARTICLE HAS BEEN RETRACTED. Ahimastos AA, Walker PJ, Askew C, et al. Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. JAMA. 2013;309:453-60. 23385271
[Value of the injury severity score (ISS)].

Field: Medicine (Health Sciences)

The injury severity score (ISS) has been most widely accepted as a practicable method of classifying traumatised patients (ie., patients with accident injuries) according to the severity of their injuries, and has become more popular than all other comparable classification systems. By allocating the patients to different severity groups, it facilitates their classification in respect of prognosis. Over and above this, it enables comparison of patient groups of different hospitals. The authors investigated the validity of ISS classification by studying the case records of 432 patients in a traumatological intensive-care ward. They found good correlation between ISS score on the one hand, and lethality, requirements of banked blood during first-aid care and duration of treatment and artificial respiration of survivors on the other. However, the mean survival time of those patients who had died, did not reveal any connection with the severity of the injury. It is definitely impossible to arrive at any prognosis for an individual patient on the basis of his ISS classification. With increasing age, lethality after an accident increases even if the injury is less severe. The validity of ISS could be increased further if the age of the patients could be taken into account as well.
Reading-Related Literacy Activities of American Adults: Time Spent, Task Types, and Cognitive Skills Used

Field: Social Sciences (Social Sciences)

This article presents data on the types and duration of reading-related activities reported by a volunteer sample of 400 adults (demographically similar to the U.S. adult population age 20 and older in terms of race, ethnicity, education, and working status) in the 2005 Real-World Tasks Study. This diary study revealed that adults spent, on average, 4.5 hours a day on activities that involve reading printed and electronic texts, a relatively higher percentage of which occurred on working than on nonworking days. Prose and quantitative tasks were more common (98 and 94 minutes, respectively) than hybrid and document tasks (40 and 25 minutes, respectively). Hybrid tasks constituted 15% of the total daily reading-related literacy time, a novel finding because hybrid tasks have not been defined or included in any previous studies. Most reading-related activities required application skills to act on or use information to function in society and achieve goals (e.g., to decide which health insurance plan to purchase). In terms of texts, adults spent about 191 minutes a day using prose texts but only 116 minutes using document texts. The largest portion of reading-related time of prose texts was spent on periodicals, journals, newspapers, electronic correspondence, and informational texts. Lists accounted for over a fourth of the time spent on activities involving reading document texts. These results have been used in assessment development to ensure that assessment tasks reflect everyday literacy activities. The data may also benefit literacy practitioners in creating materials that reflect adults' daily reading practices.
Market Fluctuations and the Crocs' Resurgence

Field: Business, Management and Accounting (Social Sciences)

This paper delves into the reasons for the decline in sales of Crocs and the reasons for its counterattack. The decline in sales of Crocs was mainly affected by changing fashion trends and consumer preferences, a lack of effective marketing and promotion strategies, and the proliferation of copycat shoes in the market. However, Crocs managed to fight back by focusing on providing a comfortable foot feel, shifting marketing strategies and leveraging the influence of social media, as well as the unique characteristics of Crocs. This reversal not only led to the economic recovery of the shoe industry and workshops but also regained the importance of Crocs in the field of culture and fashion. There are a few suggestions to pay attention to for the future prospects and sustainability of Crocs: First, pay close attention to changes in consumer trends and adjust product design and promotion strategies in time to adapt to changes in market demand. Secondly, pay attention to the safety of Crocs, continuously improve the comfort and quality of products, and ensure consumer satisfaction and trust. Finally, strengthen intellectual property protection, prevent infringement of counterfeit products, and maintain brand image and market share. By proactively addressing these critical issues, Crocs can secure its future growth and continue to succeed in the highly competitive footwear market.