jimnoneill/paper-to-field-training huggingface dataset:
Allogeneic Hematopoietic Stem Cell Transplantation-Induced Anaphylaxis in 2 Pediatric Cases.

Field: Medicine (Health Sciences)

Hematopoietic stem cell transplantation is a curative treatment for many malignant and nonmalignant diseases in children and adults. It is performed with peripheral blood stem cells, bone marrow, and umbilical cord blood. Anaphylaxis may occur during hematopoietic stem cell transplantation, similar to that shown with blood transfusions. In children, although a few cases of anaphylaxis have been reported with cord blood transplantation, no cases of anaphylaxis have been reported with other hematopoietic stem cell transplantations. In this case report, we present the cases of 2 children, one diagnosed with thalassemia major and the other with aplastic anemia, both of whom developed anaphylaxis associated with bone marrow transplantation products cryopreserved with dimethyl sulfoxide and hydroxyethyl starch. Hematopoietic stem cell transplantation-induced anaphylaxis could be associated with cryoprotective agents, especially dimethyl sulfoxide, and alloantigens. In both anaphy-lactic reactions, dimethyl sulfoxide was thought to be the trigger, but it could not be excluded that it was related to stem cell components, plasma, or hydroxyethyl starch.
Occurrence Download

Field: Agricultural and Biological Sciences (Life Sciences)

A dataset containing 450 species occurrences available in GBIF matching the query: { "and" : [ "TaxonKey is Rubus elegantispinosus", "Country is United Kingdom of Great Britain and Northern Ireland", "HasCoordinate is true" ] } The dataset includes 450 records from 17 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0009737-251009101135966/datasets/export for details. Data from some individual datasets included in this download may be licensed under less restrictive terms.
Impacts of Climate and Land use Changes on Streamflow in the Mun-Chi River Basin, the Largest Tributary of the Mekong River

Field: Environmental Science (Physical Sciences)

The impact of climate change and human activities poses significant challenges in the tropical region of Southeast Asia, specifically within the Mun-Chi River Basin, the largest tributary of the Mekong River in Thailand. The bias-corrected MPI-ESM1-2-LR, the most appropriate Global Climate Model (GCM) under the Coupled Model Intercomparison Project Phase 6 (CMIP6) for projecting Mun-Chi River flow, represent future climate variations in the basin. The analysis reveals forthcoming transformations in future land use, with cropland areas transitioning into forests and urban areas. The projected annual streamflow contributing to the Lower Mekong River is expected to increase by 1.14% to 3.49% in 2023-2035 and 1.84% to 4.26% in 2036-2050, with 67.17% attributed to climate change and 32.83% to land-use change. Temporal variations in the future flow regime reveal a wetter wet season and a drier dry season in this catchment. During the wet season, streamflow is projected to rise by 4.97% to 17.67% in 2023-2035 and 9.97% to 24.08% in 2036-2050. In contrast, the dry season is expected to experience a decrease of -2.69% to -9.15% in 2023-2035 and -6.28% to -17.10% in 2036-2050. These seasonal contrasts suggest a potential increase in extreme hydrological events, presenting challenges for efficient water resource management in this watershed and downstream countries. Consequently, effective water regulation and land-use policies are deemed crucial for sustainable management in the Mun-Chi River Basin.
Media Digital Literacy Program in Improving Parental Mediation Efficacy with Community Nursing Approach

Field: Health Professions (Health Sciences)

The research started with initial screening by filling out a questionnaire on gadgets usage for elementary students. The treatment group (n=35) enrolled in 4 online meeting sessions with seven respondents per small group. In the same research period, the control group (n=35) enrolled in only one big class session about parental mediation. After the intervention, the sample measured the level of maternal self-efficacy. Univariate statistics determined the respondent's characteristics, parental mediation of the use of gadgets in children, and the mother's self-efficacy in parental mediation before and after the program. The data were not normally distributed using the Shapiro Wilk test. Thus differences in maternal self-efficacy before and after treatment were analyzed using Wilcoxon. Simultaneously, differences in self-efficacy between the treatment group and the control group were analyzed using Mann Whitney. Digital media literacy significantly increased mothers' self-efficacy in mediating the use of gadgets by children (p <0.05)
LncRNA MEG8 sponging miR-181a-5p contributes to M1 macrophage polarization by regulating SHP2 expression in Henoch-Schonlein purpura rats

Field: Medicine (Health Sciences)

The lncRNA MEG8 sponged miR-181a-5p, which contributes to M1 macrophage polarization by regulating SHP2 expression in HSP rats.Key MessagesLncRNA MEG8 downregulation and M2 polarization in Henoch Schonlein purpura rats.MEG8 upregulation enhances M1 polarization and suppresses JAK2/STAT3 pathway.MEG8 sponges miRNA-181a-5p to regulate SHP2 expression.MiRNA-181a-5p upregulation reverses lncRNA MEG8-mediated enhancement of M1 polarization and inhibition of JAK2/STAT3 pathway.SHP2 downregulation reverses lncRNA MEG8-mediated enhancement of M1 polarization and inhibition of JAK2/STAT3 pathway.
Johan Åkerman vs. Ragnar Frisch on Quantitative Business Cycle Analysis

Field: Economics, Econometrics and Finance (Social Sciences)

The article provides an account of the debate that took place between the late 1920s and the mid 1930s between the Scandinavian economists Johan Åkerman and Ragnar Frisch about the quantitative treatment of aggregate economic fluctuations. Although both interpreted the business cycle as an interference phenomenon between waves of different order, they disagreed on how to model its generation mechanism. Åkerman's emphasis on seasonal changes in his path-breaking application of harmonic analysis to economic fluctuations was rejected by Frisch, who instead suggested the explanation of business cycles as free oscillations determined by impulse and propagation mechanisms.
The Right to Food: legal, political and human implications for a food security agenda

Field: Social Sciences (Social Sciences)

This article understands food security as a “wicked problem” and suggests that the rights-based approach addresses some of the impasses by shifting the key concern from food to hunger, and placing the human person at the centre of development. The 2004FAO Voluntary Guidelines on the Right to Foodprovide clarification on the rights-based approach and point to how the right to food can be incorporated into government strategies and institutions. A landmark legislative example from India illustrates how the rights approach can empower a range of detailed programmatic actions on hunger, which in turn reinforce other socio-economic rights. The conclusion reflects on how the right to food and the right to development bring important substantive dimensions to the current agenda for policy coherence in development assistance and cooperation.
Ischemic Stroke in a 7-Month-Old Infant With Antiphospholipid Antibody and Homozygous C677T Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism

Field: Medicine (Health Sciences)

Prothrombotic risk factors in children with ischemic stroke have been increasingly recognized with recent developments in technology. Extensive evaluation including a detailed family history is required to identify various inherited or acquired prothrombotic conditions. We report a 7-month-old male who presented with right hemiparesis. Acute cerebral infarction in the area supplied by the left lenticulostriate artery was confirmed through magnetic resonance imaging. De novo synthesis of antiphospholipid antibodies and homozygous methylenetetrahydrofolate reductase (MTHFR) polymorphism were identified as presumed prothrombotic risk factors. His twin sister and mother were also positive for antiphospholipid antibodies. Multiple risk factors for ischemic stroke should be considered, particularly in the perinatal and infancy period. This case also underlines the rare familial occurrence of antiphospholipid antibodies and its relationship to ischemic stroke in infancy.
Connecting Scales: RGE Effects in the SMEFT at the LHC and Future Colliders

Field: Physics and Astronomy (Physical Sciences)

Global interpretations of particle physics data within the framework of the Standard Model Effective Field Theory (SMEFT), including their matching to UV-complete models, involve energy scales potentially spanning several orders of magnitude. Relating these measurements among them in terms of a common energy scale is enabled by the Renormalisation Group Equations (RGEs). Here we present a systematic assessment of the impact of RGEs, accounting for QCD, electroweak, and Yukawa corrections, in a global SMEFT fit of LEP and LHC data where individual cross-sections are assigned a characteristic energy scale. We also quantify the impact of the RGE effects in projected global fits at the HL-LHC and the FCC-ee. Finally, we assess the role that RGEs play on the sensitivity at HL-LHC and FCC-ee to representative one-particle UV models matched onto SMEFT either at tree and one-loop level. Our study emphasizes the importance of a consistent treatment of energy scales to achieve the best precision and accuracy in indirect searches for heavy new physics through precision measurements.
The lethal grip of heat: mapping the heat wave-mortality nexus in Spain (1975-2019)

Field: Medicine (Health Sciences)

Nowadays, the rise in the global temperatures are a source of concern, particularly in the Mediterranean region, where Spain is already witnessing notable consequences for its aging population. Predictions for the end of the XXI century reveal a persistent increase in air temperatures along with an increment of extreme episodes. Abnormal heat, once considered an 'environmental accident', is now a serious public threat. This contribution endeavors to quantify the added effects of heat wave exposure on mortality by demographic and socioeconomic strata during the period of 45 years in Spain at the provincial level. Moreover, we aim to explore the temporal evolution in these effects and variations in its spatial patterns, especially focusing on the inequality aspects that shape the health outcomes in an increasingly aging population.Here we leverage daily individual mortality data and other contextual data on population from the National Institute of Statistics of Spain and air temperature estimates from the ERA5 global reanalysis. We also use the historical settlement data as a proxy for population distribution from 1975 onward. To estimate the main and added effects of heat waves we fit a quasi-Poisson time-series regression model using a distributed lag non-linear model with 10 days of lag, controlling for trends and day of the week.We analyze approximately 15.8 million of deaths registered in Spain between 1975 and 2019. During the selected time window, we expect to see a shift in the temperature-mortality association from a V-shape in the first decades of the observation to a U-shape by the end of the period all across the provinces, thus revealing a progressive flattening of the exposure-response curve. We also expect to observe an overall reduction in the mortality burden associated with the temperatures. In particular, we anticipate more significant and rapid decline in the cold-related risks and attributable fractions in comparison with the heat-related ones, with some latitudinal variations across the country.On the other hand, we witness a steady increase in the incidence of the heat wave episodes with time all over the country. We expect to see a positive added effect of heat wave on mortality, however this effect is assumed to be smaller than the primary effect. In addition, we anticipate observing variations in the effect depending on the heat wave order, duration, intensity, geographic location and demographic strata. The largest added effects are expected for the longest and strongest heat waves in the oldest-old population in the less accustomed to extreme heat areas.
The role of germ-line immunoglobulins in autoimmunity and B cell activation

Field: Immunology and Microbiology (Life Sciences)

The human antibody response to the AD-2S1 epitope of glycoprotein B (gB) of human cytomegalovirus (HCMV) is dominated by a family of closely related somatically mutated antibodies that are all derived from the same V H and V K germline genes. Our laboratory has previously reconstructed the putative germ-line-based ancestor of a somatically hypermutated antibody (8F9) against the AD-2S1 and characterized and compared the binding of the germline- based ancestral immunoglobulin and 8F9 (Igs) to the AD-2SI epitope. IgG1 versions of these antibodies bound to AD-2S1 by ELISA and glycoprotein B (gB) by flow cytometry. Here, I show that 8F9 neutralizes viral infectivity whereas the germ-line Igs do not. However, the germ-line Igs bind to an unidentified, phylogenetically conserved auto-antigen. Small changes in the binding site of the germ-line Igs abolished binding to the auto-antigen. Even though mechanisms do exist during B cell development to eliminate self-reactive B cells, these observations suggest that autoreactivity is not necessarily a barrier for immature B cells to further develop into follicular B cells that subsequently undergo antigen-driven affinity maturation. Our observations that the hypermutated high affinity 8F9 antibody was derived from a primary immunoglobulin that was reactive with both an auto-antigen and AD-2S1 raise important questions including 1) the threshold of affinity required for triggering the clonal expansion and somatic mutation of new B cells, and, 2) the role of low-affinity cross-reactivity with ubiquitous antigens (eg self-antigens), in rescuing B lymphocytes with primary receptors for important pathogens from "death by neglect". To further understand the initial primary B cell receptor (BCR) response to AD-2S1, we expressed the membrane IgM forms of the 8F9 and primary germ-line Igs. In our experiments, the human germ-line Igs and 8F9 were expressed in a mouse cell-line as membrane IgM. I showed that cross-linking this human IgM triggered calcium release and tyrosine phosphorylation of intra-cellular signalling molecules. Morever, the membrane IgM bound AD2S1. Thus, I demonstrated that the human IgM expressed in a murine cell line is capable of activating many B cell responses and can serve as an in vitro model to look at affinity threshold. I also constructed lentiviral vectors to enable infection of RAG-1 knockout stem cells and reconstitution of RAG-1 knockout mice with B cells expressing human germ-line IgMs. The in vitro and in vivo systems will be useful in studying the affinity threshold needed to initiate B cell activation and other questions that are important in B cell immunity.
Thresholds of spin wave envelope soliton formation in magnetic films with dissipation (abstract)

Field: Physics and Astronomy (Physical Sciences)

The nonlinear mechanism responsible for the spin wave envelope soliton formation in magnetic films from input pulses of finite duration is the four-wave process with conservation law ω(k0)+ω(k0)=ω(k0+κ)+ω(k0−κ), κ≪k0. This process is also responsible for modulation instability of CW wave in a nonlinear dispersive medium and can only take place if the nonlinearity N and the dispersion D in the medium have opposite signs. In a dissipative medium this process has a finite amplitude threshold determined by the dissipation parameter γ and the effective ‘‘detuning’’ Δω proportional to the dispersion D and the square of the modulation wave number κ, ‖φ‖th2=[γ2+(Δω)2/4]/‖NΔω‖, hereafter referred to as Eq. (1), where ‖φ‖ is the dimensionless wave amplitude. For the process of modulational instability of a CW wave Δω=Dκ2. For the process of soliton formation from a finite input pulse (of the duration T) Δω=Dκ2n, where κn=(2n−1)π/vT, n is the number of solitons formed, and v is the group velocity of spin waves. Equation (1) gives a good description of the recent measurements of thresholds of spin wave envelope soliton formation in YIG films presented in Ref. . In particular, describes correctly the shape of the threshold curve, positions of threshold minima for the formation of one and two solitons, and explains the finite intercept on the threshold power dependence on the inverse square of the input pulse duration that was not explained in Ref. .
A Study of the use of address terms among Javanese servants toward their Tionghoa masters in Surabaya

Field: Arts and Humanities (Social Sciences)

This study is an analysis of the use of address term among w~\mv*4T> 4-f trnnA fhaii* Tt /->?-> rrVy /-wo m o r f a rp T^V>#> or>ft*nfop -'i V ctino LV/ vvcu v* invu x IUH^IIUU iitcioiwi o. x nw vvi uvi vun^vnu u-ivo only oil the address terms used by the servants. Related to the study, the writer uses theories of definition of address form by Krisdaiaksana and Bright, and theories of the use of address form by Holmes, Wardhaugh, ?-f L O > f A A U 1 1U .*. KSX V *> U l lU *-->! V f l it MA AW* %_? 11111U> A , 111 g V l t l l lg VandC4.L44., CilV* VVI ltV/1 U1JIV1J C4 kJV/k V/X \J U V J H V ^l lJ i.V/ 11V1 respondents. The questions are focused to answer four main questions in this study: (1) What address terms are used by the Javanese servants to their 1v> VUUvUUVll V/A. tHW rc9 /^^ F^n nap VI A^ A A .A. A V/ A Ab^A 1 WA A A A%>%h> V ^^A %~* * QHHI-^CO thp r.1H HIQIP mqctprc otv> A V V11V V IM 111M1V 111MI/WV1 kS V** ^/ Bapak, Tuan Besar, Tuan, Engkong, Papa, Om, Yuk Dhe, and Yuk. Regarding the servants; age of the servants gives bigger influence than the education to the way they address their masters. Regarding the masters; age, education, and sex of the masters offer effects to the servants' way of addressing them. The writer also finds that the most reason affecting the use of the address term is the servants' own wish.
Vascular Endothelial Growth Factor 189 mRNA Isoform Expression Specifically Correlates With Tumor Angiogenesis, Patient Survival, and Postoperative Relapse in Non–Small-Cell Lung Cancer

Field: Medicine (Health Sciences)

PURPOSE: The purpose of this study was to evaluate the correlation between the expression of four different vascular endothelial growth factor (VEGF) mRNA isoforms (VEGF121, VEGF165, VEGF 189, and VEGF206) and the clinicopathologic characteristics, tumor angiogenesis, and outcome of patients with non–small-cell lung cancer. PATIENTS AND METHODS: We examined the expression of four different VEGF mRNA isoforms in 57 non–small-cell lung cancers using reverse transcriptase polymerase chain reaction and the tumor angiogenesis using immunohistochemical staining. RESULTS: All 57 lung cancer samples expressed the VEGF121, VEGF165, and VEGF189 mRNA isoforms, and three expressed the VEGF206 mRNA isoform. A high tumoral VEGF189 mRNA isoform expression ratio was associated with a high intratumoral microvessel count (P = .013), short survival (< 24 months; P = .001), and early postoperative relapse (< 12 months; P = .001). Survival and postoperative relapse time were significantly shorter in patients with a high compared with a low tumor VEGF189 mRNA isoform expression ratio (P = .0001 and P = .0086, respectively, log-rank test). In contrast, the VEGF165 and VEGF 206 mRNA isoform expression ratios showed no statistical correlation with tumor angiogenesis, postoperative relapse time, or survival. A high VEGF121 mRNA isoform expression ratio was associated with short survival (< 24 months) and early relapse (< 12 months). Multivariate analysis showed that VEGF 189 mRNA isoform expression, microvessel count, and nodal status were the most important independent prognostic factors for patient survival and postoperation recurrence. CONCLUSION: The VEGF189 mRNA isoform expression ratio shows a greater correlation with tumor angiogenesis, postoperative relapse time, and survival than do the expression ratios for the VEGF121, VEGF165, and VEGF206 mRNA isoforms and can be used as a prognostic indicator for patients with non–small-cell lung cancers.
Competence Implies Credibility

Field: Economics, Econometrics and Finance (Social Sciences)

The (reputation for) competence of a central bank at doing its job makes monetary policy under discretion credible and transparent. Based on its reading of the state of the economy, the central bank announces its policy intentions to the public in a cheap-talk game. The precision of its private signal measures its competence. The fineness of the equilibrium message space measures its credibility and transparency. This is increasing in the competence/inflation bias ratio: the public expects a competent central bank to use its discretion more to pursue its “objective” targets than to surprise expectations and stimulate output. (JEL E52, E58)
Gender differences in repetitive behaviours in children diagnosed with autism spectrum disorder

Field: Psychology (Social Sciences)

Repetitive behaviours are one of the main criteria contributing to a diagnosis of autism spectrum disorder (ASD), along with deficits in social communication and interaction. They refer to predictable actions that the child displays repeatedly and/or performs similarly or identically. These actions include a wide range of behaviours such as motor stereotypies, preoccupation with parts of objects, insistence on sameness, limited interests, ritualised behaviours, and sensory hypo- and hyper-reactivity. The prevalence of ASD is steadily increasing, and it is a disorder that has been diagnosed more frequently in boys than girls since its inception. Numerous studies have reported contradictory findings regarding gender differences in the quantity and quality of repetitive behaviours. Therefore, the aim of this study was to investigate whether there are gender differences in repetitive behaviours in children with ASD between the ages of 6 and 9 years, as well as to describe these differences. The participants included 50 parents of children with autism spectrum disorder (30 boys and 20 girls), who were between 6 and 9 years old and had (above) average intellectual abilities. All participants completed the Revised Scale of Repetitive Behaviours and the data obtained were statistically analysed using non-parametric methods. The results indicate that girls exhibit more self-injurious behaviours and less restricted behaviours than boys. No statistically significant gender differences were found for the other subscales of the questionnaire, suggesting that other behaviours occur equally in boys and girls. Overall, repetitive behaviours can be considered as an equally moderate problem for both parents of boys and girls.
Measurement and Potential Applications of Time-lapse Attenuation

Field: Earth and Planetary Sciences (Physical Sciences)

Summary Can we use other time-lapse seismic attributes to compliment our measurements of travel-time and reflectivity changes? In this paper we have measured attenuation changes in a seismic reservoir undergoing depletion and in some locations water injection. We will discuss these measurements in three sections, covering: 1.Potential uses of time-lapse attenuation measurements. What can we use them for? Time-lapse inverse Q? Interpretation? For this we will show an example of trying to separate water and gas saturation effects. 2.Real signal or an artefact? Could we just be looking at an apparent effect from, for example, migration using the same velocities for all vintages? Is a dedicated workflow necessary to extract what might be very subtle signals? 3.What are the underlying mechanisms controlling attenuation? What could we learn if we made these time-lapse measurements in other reservoirs?