jimnoneill/paper-to-field-training huggingface dataset:
The influence of weather conditions on the qualitative characteristics of elite black currant berries’ forms of Federal Agrarian Scientific Center of the North-East breeding

Field: Agricultural and Biological Sciences (Life Sciences)

The studies were held on the experimental garden of N. V. Rudnitsky Federal Agrarian Scientific Center of the NorthEast in 2015-2018. The aim of research was to estimate the elite black currant forms according to biochemical composition and large-fruitiness in conditions of Kirov region and to reveal the sources of valuable traits. Nine elite black currant forms, 2013-year landing, breeding in Federal Agrarian Scientific Center of the North-East, and earlier transferred on State testing varieties Arcadia, Sapfir were the objects of research. The control variety was Vologda. Rregistrations, observations and biochemical analyzes were carried out according to generally accepted methods. The variability of weather conditions let us estimate their influence on qualitative berry composition of new elite black currant forms. As result of studying of elite black currant forms, the sources of features were identified: on large-fruitiness are 71-2-07 (Mortti x Chudnoe mgnovenye) and 64-4-07 (Chernovka x Karachinskaya) forms; on sugar content - 46-1-07 (Alivas x Chudnoe mgnovenye) form; on ascorbic acid is 27-3-07 form (the origin is not known). These genotypes are valuable as a source material for further breeding to increase the level of qualitative characteristics. Strong positive correlation of berry mass with rainfall during the period from May to July (r=0,86) and moisture index of growing season (r=0,85) was established. All studied elite forms were prominent by stability of dry solids storage (V=3,12-8,19 %). The storage of ascorbic acid is deeply connected with the sum of effective temperatures and mid temperature of July (r=0,95). A significant influence of weather conditions on content of ascorbic acid (V=23,08 %) was revealed. Strong positive correlation of total titrated acidity with the sum of rainfall in July (r=0,86) and moisture index of berry growing in July (r=0,93); strong negative connection with the sum of effective temperatures in vegetation growing period and crop ripening (r= -0,70) were shown. Middle positive correlation between sugar accumulation and middle air temperature in July was determined (r=0, 51). Weather conditions in ripening stage of berries had an important influence on sugar content (V=24, 98-52,96 %).
Artificial antigen-presenting cells expressing AFP158-166 peptide and interleukin-15 activate AFP-specific cytotoxic T lymphocytes

Field: Medicine (Health Sciences)

Professional antigen-presenting cells (APCs) are potent generators of tumor antigen-specific cytotoxic T lymphocytes (CTLs) for adoptive immunotherapy; however, generation of APCs is cumbersome, expensive, and subject to the tumor microenvironment. Artificial APCs (aAPCs) have been developed as a cost-effective alternative to APCs. We developed a cellular aAPC that efficiently generated alpha-fetoprotein (AFP)-specific CTLs. We genetically modified the human B cell lymphoma cell line BJAB with a lentiviral vector to establish an aAPC called BA15. The expression of AFP(158-166)-HLA-A*02:01 complex, CD80, CD86, and interleukin (IL)-15 in BA15 cells was assessed. The efficiency of BA15 at generating AFP-specific CTLs and the specific cytotoxicity of CTLs against AFP+ cells were also determined. BA15 cells expressed high levels of AFP(158-166) peptide, HLA-A2, CD80, CD86, and IL-15. BA15 cells also exhibited higher efficiency in generating AFP-specific CTLs than did dendritic cells. These CTLs had greater cytotoxicity against AFP+ hepatocellular carcinoma cells than did CTLs obtained from dendritic cells in vitro and in vivo. Our novel aAPC system could provide a robust platform for the generation of functional AFP-specific CTLs for adoptive immunotherapy of hepatocellular carcinoma.
Extraction of antioxidants from borage (Borago officinalis L.) leaves—Optimization by response surface method and application in oil-in-water emulsions

Field: Agricultural and Biological Sciences (Life Sciences)

Borage (Borago officinalis L.) is a typical Spanish plant. During processing, 60% are leaves. The aim of this work is to model and optimize the extraction of polyphenol from borage leaves using the response surface method (RSM) and to use this extract for application in emulsions. The responses were: total polyphenol content (TPC), antioxidant capacity by ORAC, and rosmarinic acid by HPLC. The ranges of the variables temperature, ethanol content and time were 50–90 °C, 0%–30%–60% ethanol (v/v), and 10–15 min. For ethanolic extraction, optimal conditions were at 75.9 °C, 52% ethanol and 14.8 min, yielding activity of 27.05 mg GAE/g DW TPC; 115.96 mg TE/g DW in ORAC and 11.02 mg/L rosmarinic acid. For water extraction, optimal activity was achieved with extraction at 98.3 °C and 22 min, with responses of 22.3 mg GAE/g DW TPC; 81.6 mg TE/g DW in ORAC and 3.9 mg/L rosmarinic acid. The significant variables were ethanol concentration and temperature. For emulsions, the peroxide value was inhibited by 60% for 3% extract concentration; and 80% with 3% extract concentration and 0.2% of BSA. The p-anisidine value between the control and the emulsion with 3% extract was reduced to 73.6% and with BSA 86.3%, and others concentrations had similar behavior.
Trifluoromethyl Ketones from Enolizable Carboxylic Acids via Enediolate Trifluoroacetylation/Decarboxylation

Field: Chemistry (Physical Sciences)

Primary and secondary (enolizable) carboxylic acids were converted in a single step to trifluoromethyl ketones. Treatment of the acid with 2.2 equiv of LDA generated an enediolate that was trifluoroacetylated with EtO<sub>2</sub>CCF<sub>3</sub>. Quenching the reaction mixture with aqueous HCl resulted in rapid decarboxylation and provided the trifluoromethyl ketone product in good yield. The process may be performed at −20 °C with a slight reduction in yield. The reaction was extended to the preparation of pentafluoroethyl and chlorodifluoromethyl ketones.
Revolutionizing brain–computer interfaces: Compact and high-speed wireless neural signal acquisition

Field: Engineering (Physical Sciences)

A brain–computer interface (BCI) facilitates the connection between the human brain and external devices by decoding neurophysiological signals, thereby enabling seamless interaction between humans and machines. However, existing neural signal acquisition systems often suffer from limited channel counts, low sampling rates, and challenges in miniaturization and wireless bandwidth, which restrict their ability to support large-scale and real-time neural recordings. Given the rapid advancements in BCI technologies and the increasing demand for high-resolution neural data, there is an imperative need for BCI systems that are high-throughput, high-speed, and miniaturized. This paper presents a wireless neural signal acquisition system based on FPGA technology, supporting 1024 channels at 32 kSPS and employing a stacked architecture for compact, low-power wireless transmission. Following the creation of the functional prototype, laboratory electrical performance tests were conducted. The system exhibited a noise voltage of 8.56 μVrms, which is in close proximity to the 6 μVrms specified by the chip. In addition, the system accurately captured weak sine wave inputs in both time and frequency domains, confirming its ability to record weak bioelectrical signals. Subsequent animal experiments involving mice implanted with EEG electrodes demonstrated that the system could reliably acquire brain neural signals in real time. The maximum and minimum values of signal-to-noise ratios among the channels were measured at 28.66 and 30.56 dB, thereby providing additional validation for the system's signal quality and consistency.
Influence of Copper on the Microstructural, Mechanical, and Biological Properties of Commercially Pure Zn-Based Alloys for a Potential Biodegradable Implant

Field: Materials Science (Physical Sciences)

Three Zn-based alloys (Zn1Cu, Zn2Cu, and Zn3Cu) were developed by the addition of Cu (1, 2, and 3 wt %) into commercially pure Zn. This report systematically investigates the potential for these newly developed Zn-based alloys as biodegradable materials. Microstructural studies reveal the presence of spherical-shaped nanosized precipitates of ε-CuZn4 in the Zn1Cu alloy, whereas Zn2Cu and Zn3Cu alloys exhibit the presence of both micron- and nanosized precipitates of ε-CuZn4. The mechanical properties such as hardness, tensile and compressive strengths improve significantly with an increase in the amount of Cu in the alloy. The Zn3Cu alloy exhibits the highest yield strength (225 ± 9 MPa) and ultimate tensile strength (330 ± 12 MPa) among all of the alloys, which are ∼2.7 and 2 times higher than those of pure Zn. In vitro degradation behavior is evaluated by the potentiodynamic polarization study and immersion testing in Hank's solution for 20 and 75 days. The corrosion rate after both polarization and immersion testing follows the order of pure Zn < Zn1Cu < Zn3Cu < Zn2Cu. An electrochemical impedance spectroscopy (EIS) study also concludes that Zn2Cu shows the lowest corrosion resistance. The % cell viability values of 3T3 fibroblasts cells after 5 days of culture in a 50% diluted extract of pure Zn, Zn2Cu, and Zn3Cu alloys are 76 ± 0.024, 86.18 ± 0.033, and 92.9 ± 0.026%, respectively, establishing the improved cytocompatibility of the alloys as compared to pure Zn. Furthermore, an antibacterial study also reveals that the Zn3Cu alloy exhibits 80, 67, and 100% increases in the zone of inhibition (ZOI) for Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa bacteria, respectively, as compared to that of pure Zn.
Association Between Thrombotic Microangiopathy and Reduced ADAMTS13 Activity in Malignant Hypertension

Field: Medicine (Health Sciences)

The thrombotic microangiopathy observed in malignant hypertension is similar to that of thrombotic thrombocytopenic purpura, which is associated with a deficiency of ADAMTS13, a von Willebrand factor (VWF)–cleaving protease that cleaves large prothrombogenic multimers. We hypothesized that ADAMTS13 is deficient in malignant hypertension and that the severity of thrombotic microangiopathy is associated with decreased ADAMTS13 activity. We included 20 patients with malignant and 20 patients with severe hypertension, and 20 matched normotensive individuals served as control subjects. VWF, active VWF, and free hemoglobin were assessed to explore predictors of ADAMTS13 activity. Patients with malignant hypertension had lower ADAMTS13 activity (80%; interquartile range: 53% to 130%) compared with control subjects (99% interquartile range: 82% to 129%; P <0.01) but not compared with patients with severe hypertension ( P =0.14). ADAMTS13 activity negatively correlated with lactic dehydrogenase levels after logarithmic transformation ( r =−0.65; P <0.001) and was associated with platelet count ( r =0.34; P =0.04) and the presence of schistocytes ( r =−0.37; P =0.02). Apart from the association with thrombotic microangiopathy, ADAMTS13 was inversely associated with creatinine ( r =−0.42; P =0.008). Increasing levels of VWF were associated with a decrease in ADAMTS13 activity ( r =−0.34; P =0.03). There was no significant association between ADAMTS13 activity and other parameters, including blood pressure. In conclusion, ADAMTS13 is decreased in malignant hypertension and associated with the severity of thrombotic microangiopathy, likely because of the release of VWF after endothelium stimulation. A severe deficiency could not be demonstrated. More studies are needed to identify the role of ADAMTS13 in the thrombotic microangiopathy and ischemic complications of malignant hypertension.
Comprehensive analysis of tubular combustion chambers in Turbo-Ramjet engines for enhanced hypersonic propulsion

Field: Engineering (Physical Sciences)

Anticipating a doubling in global air travel demand by 2040, the present work underscores the need for innovation in aviation propulsion systems. This study presents the design and analysis of tubular combustors for lower Mach numbers in Turbo-Ramjet engines, utilizing input parameters derived from automotive turbochargers. The combustion chamber design is based on thermodynamic analysis, incorporating empirical data for optimal configuration. Three-dimensional simulations were conducted using CATIA V5 and ANSYS 2018 software to model and analyze three geometric configurations of chamber. Various configurations, including those with and without cooling holes and swirl vanes, were used to analyze fluid dynamics and combustion behavior. Velocity and temperature profiles were assessed at specific positions along the combustor, notably at x = 73 mm, x = 138 mm, and x = 195 mm. Simulation results indicate that MODEL 1, without cooling holes, exhibited non-uniform combustion with a peak surface temperature. MODEL 2 showed poor flame stabilization due to the absence of a swirl vane. MODEL 3, achieved optimal performance, with a peak temperature of 2241 K and outlet temperature reduction near the walls to approximately 1124 K and with shortest ignition delay of 40 mm. These findings, supported by graphical results, highlight MODEL 3′s suitability for efficient combustor design and performance optimization.
Midwives’ adherence to targeted postpartum care guidelines on immediate postpartum assessment at public hospitals in Migori County, Kenya

Field: Health Professions (Health Sciences)

Background: A maternal death occurs globally every two minutes due to pregnancy or childbirth complications. Risk is highest in Sub-Saharan Africa (1:41) compared to the developed world (1:5300). The postpartum period accounts for 60% of maternal deaths, with half occurring within 24 hours after birth, mainly from postpartum hemorrhage and eclampsia. Many of these deaths are linked to suboptimal immediate postpartum assessment (IPPA). This study assessed midwives’ adherence to the targeted postpartum care (TPPC) guideline on IPPA in public hospitals in Migori County, Kenya. Methods: An analytical cross-sectional study was conducted among midwives in level 4 public hospitals in the period September 2023 to April, 2024. Sample size was calculated using Yamane's formula. Purposive sampling was used for hospital selection, and simple random sampling for participants. Participants with active practicing license and at least three months of experience in a maternity ward or MCH clinic were included. Those on orientation or internship, with expired licenses, or on leave were excluded. Data were collected via structured questionnaires and analyzed using SPSS version 28. Descriptive statistics included means and percentages; inferential analysis used logistic regression and Chi-square with significance at p<0.05 and p<0.05 respectively. Results: Midwives’ adherence to the TPPC guideline was moderate (65.48%). Age (p=0.014), experience (p=0.040), CPD frequency (p=0.018), and awareness of the guideline (p=0.034) were significantly associated with adherence. Conclusions: Moderate adherence was observed, with CPD, age, experience, and guideline awareness influencing compliance. Full adherence is vital for improving maternal outcomes and reducing preventable deaths. Strengthening IPPA enforcement and targeted CPD on identified gaps is critical for enhanced adherence.
Henri de Maupas du Tour: The Funeral Oration for Vincent de Paul 23 November 1660

Field: Arts and Humanities (Social Sciences)

The first English translation of the funeral oration in memory of Vincent de Paul delivered by Bishop Henri de Maupas du Tour on 23 November 1660. The text of the oration was published in January 1661. The oration is the first public reflection on the life, virtue, and accomplishment of the recently deceased Monsieur Vincent. The translation is fully annotated and is accompanied by three introductory chapters: the first discusses Maupas du Tour, the second analyzes the content of the oration, and the final chapter examines the course of the canonization cause of Vincent de Paul from his death until his canonization in 1737.
Notoedres Cati Infestation in a Cat and its Management: A Case Report

Field: Veterinary (Health Sciences)

Notoedric mange is a highly contagious and pruritic skin disease caused by burrowing mites Notoedres cati of family Sarcoptidae. Notoedric cati primarily affects cats, although it can also affect humans and other species. Present paper deals with clinical signs, diagnosis, and treatment of Notoedric mange in a kitten, aged about three and half months. In this case report, 1 kg male Persian kitten was presented to the Referral Veterinary Polyclinic of ICAR- Indian Veterinary Research Institute (IVRI), Izatnagar with a complaint of itching and alopecia for past 15 days. On physical examination skin thickening, dry crusty and scaly lesions on the face, neck and limbs could be noticed. The appetite and defecation was normal and all the clinical parameters (rectal temperature, pulse rate, heart rate etc.) were within the normal range. On laboratory examination, skin scraping was positive for Notoedres cati. Based on the history, clinical manifestations and skin scraping examination, the case was diagnosed as Notoedres cati infestation. Therapeutic management was done with Inj. ivermectin @ 200 μg/kg, b. wt, subcutaneously once in a week for four weeks along with supportive therapy by oral administration of antihistamine hydroxyzine hydrochloride @ 2.2 mg/kg b. wt thrice in a day and supplementation of multivitamin, minerals, omega 3 and omega 6 fatty acids. Owner was advised to give bath with benzyl peroxide shampoo twice in a week. Kitten showed some improvement following the second dose of ivermectin, and complete remission of clinical signs was noticed following the fourth treatment.
Case Report Motor Neuron Syndrome as a New Phenotypic Manifestation of

Field: Medicine (Health Sciences)

Copyright © 2014 Marisa Brum et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. The mutation 9185T&gt;C in ATP6 gene, associated with Leigh syndrome, was reported in only few families. Motor neuron disease (MND), both clinically and electrophysiologically, was not previously described in association with this mutation. Case Report. 33-year-old male, with family history of mitochondrial disease, presented with cognitive impairment, exercise intolerance, and progressive muscle weakness. Examination revealed global hypotonia, and proximal tetraparesis, without atrophy or fasciculation, pyramidal signs, or sensory symptoms.The laboratory findings revealed an increase of lactate and lactate/pyruvate ratio; electromyogram showed chronic neurogenic compromise; muscle biopsy was suggestive of spinal muscular atrophy and mitochondriopathy; genetic study of SMN1was negative but detected a homoplasmicmutation 9185T&gt;C inATP6 gene.His younger sister, with the samemutation, had cognitive impairment, ataxia, andmuscle weakness. EMG showed axonal peripheral neuropathy. Conclusion. This case is unique because of the benignity and the coexistence of clinical, neurophysiological, and pathological findings suggestive of MND that, although described in mitochondrial disease, have not yet been reported in association with 9185T&gt;C mutation. The present case contributes to the expansion of the phenotypic expressions of this particular mutation. 1. Background The mitochondriopathy resulting from the mutation in gene
中国民营企业国际化战略的动因和发展--对ZX公司的案例分析=Development of globalization strategy by privately-owned enterprises in China - a case study of ZX company.

Field: Business, Management and Accounting (Social Sciences)

Analysis of the current economic trend of globalization, trying to provide solutions for building sustainable competitiveness of private-owned enterprises, focusing on the globalization strategy of private companies in today's China using the theory of industrial cluster and competitive advantages of International trade.
Adaptable service composition for very-large-scale Internet of Things systems

Field: Computer Science (Physical Sciences)

The (future) Internet of Things (IoT), with service composition point of view, raises additional challenges especially with respect to handling the scale, dynamicity and heterogeneity of the target networking environment. Therefore, the services offered by IoT resources can not be composed by simply extending existing Service Oriented Architecture (SOA) approaches, since it requires the integration of a huge number of real world services that demands for the user-centric and a situation-aware composition process. In this paper, we present an architectural approach that enables efficient and adaptive composition of services by locally orchestrating the distributed web-enabled services in Very Large Scale (VLS) IoT systems and globally choreographing the different enterprise level Web services.
Study on the strength loss of Multi-hop HF Radio Propagation

Field: Physics and Astronomy (Physical Sciences)

The reflections of high frequency (HF) radio waves between ionosphere and earth’s surface make long-distance information transmission possible. In this paper, the propagation process of radio signals was analyzed and the ionosphere was simplified. Considering the strength loss of signals that occurs in the travelling process and at the reflection points, two pairs of differential equations and integral equations were established to simulate the strength variations of HF radio waves and noises. A different equation of SNR was also developed, which utilized the failure threshold of signal-noise-ratio (SNR) as a criterion to evaluate the effectiveness of signals. Meanwhile, the pace of SNR attenuation was simulated when reflections happens on calm ocean, turbulent ocean, smooth terrain and rugged terrain.
β3-adrenergic agonist counters oxidative stress and Na+-K+ pump inhibitory S-glutathionylation of placental cells: implications for preeclampsia

Field: Medicine (Health Sciences)

H/R-induced oxidative stress and deficient NO-dependent placentation are features of preeclampsia, yet nonspecific antioxidants and NO donors are ineffective. Here, activation of the microdomain-confined signaling pathway with an agonist for the eNOS-coupled β3-AR eliminates inhibitory glutathionylation of the Na + -K + pump’s β1 subunit, uncoupling of eNOS, and activation of NADPH oxidase that are sources of H/R-induced oxidative stress. The agonist also eliminates H/R-induced inhibition of trophoblast migration and their integration into an endothelial network.
Çinggis Han’ın İç Asya Halklarının Kaderine Getirdiği Değişim

Field: Arts and Humanities (Social Sciences)

In general Chinggis Khan is evaluated in terms of the campaigns and conquests he carried out on the cities and states of Central Asia and China. Here in this study the focus is on his impact on nomadic societies. While the pre-Chinggisid period is characterized by nomadic clans, tribes and principalities, the new order (jasagh) entailed membership in the army of conquest. It was not only changes in the composition of the society that these changes are visible, but also in patterns of succession. In their effort to legitimize the new order, historians of the period used old-time emotional verses in their records implying a continuity. Retrospectively it can be said that all of these developments changed Inner Asia from a society where intra-tribal strife, migrations, invasions and conquests had been the rule, to more or less homogenous “tribes” who became involved in social and religious literature, historiography thus leaving records of their culture for the posterity.