jimnoneill/paper-to-field-training huggingface dataset:
OSTEOPETROSE INFANTIL COMPLICADA E RECONSTRUÇÃO MANDIBULAR COM BIOCERÂMICA DE FOSFATO DE CALCIO BIFÁSICO – RELATO DE CASO

Field: Dentistry (Health Sciences)

Osteopetrosis is a rare, recessive genetic transmission disease, in which is determined a poor osteoclastic activity. Osseous deposition is not remodeled, leading to abnormal and poor vascularizedtissue formation. There are other hematologic systemic manifestations due to compensatory extramedullary hematopoiesis, not on the scope of this case report. We related the case of a child with osteopetrosis and the sequential history of mandibular osseous cists, abscesses, osteomyelitis, serial osseous sequestrectomies, and prolonged antibiotic therapy, unsuccessfully partial mandibular reconstruction with plate exposition. We then planned a mandibular reconstruction with a prototyped mandibula in osseous ceramic, debridement of scared and fibrotic soft tissue, and a pectoral muscle cutaneous flap to local soft tissue coverture. In 3 years of post-operatory follow-up, no complicationswere computed.
CHARACTERISTICS OF SEXUALLY TRANSMITTED DISEASES IN DERMATOLOGY DEPARTMENT, HUE CENTRAL HOSPITAL

Field: Medicine (Health Sciences)

Background: Sexually transmitted diseases are popular, not only affecting the health but also affecting the psychology and social behavior of patients. After being diagnosed, the patients were hospitalized at the Department of Dermatology, Hue Central Hospital. Therefore, we conducted this study to investigate some characteristics of sexually transmitted diseases. Materials and methods: Cross-sectional study on 72 patients having one of sexually transmitted diseases,we investigated some characteristics and clinical forms. Results: The proportion of male and female was the same and the most common age group was 15-25 with 44.4%. Most patients had two or more sexual partners with 62.5% and very few often used condoms. Only three diseases were diagnosed with genital warts, syphilis and urethritis; among them genital warts was the most common 66.7%. Latent syphilis and small papules were the most common clinical forms of syphilis, condylomata acuminata, respectively. Conclusion: Sexually transmitted diseases were relatively common among inpatient diseases and had diverse characteristics. Keywords: sexually transmitted diseases, gonorrhea, syphilis, condylomata acuminata
Investigating the role of transformational leadership and TOE framework to adopt e-government in Indonesia: the case of village information system

Field: Business, Management and Accounting (Social Sciences)

This study aims to determine the factors that influence the adoption of village information system (VIS). We propose a conceptual model involving leadership theory and technology-organisation-environment (TOE) framework. The model was examined empirically using data collected from 184 village apparatus in Indonesia. The findings reveal that a village can adopt the VIS as a form of e-government if it has a transformational village leader. This study also demonstrates the role of the TOE framework that can mediate transformational leadership factors and the intention to adopt VIS. Practically, the result of this study indicates that the adoption of VIS can be implemented if the village government has transformational leaders who can motivate awareness of the benefits of VIS (technological context), mobilise village resources (organisational context), and synergise with supra-village (environmental context).
A new method for simultaneous measurement of Seebeck coefficient and resistivity

Field: Physics and Astronomy (Physical Sciences)

A new method has been proposed and verified to measure the Seebeck coefficient and electrical resistivity of a sample in the paper. Different from the conventional method for Seebeck coefficient and resistivity measurement, the new method adopts a four-point configuration to measure both the Seebeck coefficient and resistivity. It can well identify the inhomogeneity of the sample by simply comparing the four Seebeck coefficients of different probe combinations, and it is more accurate and appropriate to take the average value of the four Seebeck coefficients as the measured result of the Seebeck coefficient of the sample than that measured by the two-point method. Furthermore, the four-point configuration makes it also very convenient to measure the resistivity by using the Van der Pauw method. The validity of this method has been verified with both the constantan alloy and p-type Bi2Te3 semiconductor samples, and the measurement results are in good agreement with those obtained by commercial available equipment.
Changing Deep-Rooted Implicit Evaluation in the Blink of an Eye: Negative Verbal Information Shifts Automatic Liking of Gandhi

Field: Psychology (Social Sciences)

It is often assumed that, once established, spontaneous or implicit evaluations are resistant to immediate change. Recent research contradicts this theoretical stance, showing that a person’s implicit evaluations of an attitude object can be changed rapidly in the face of new counterattitudinal information. Importantly, it remains unknown whether such changes can also occur for deep-rooted implicit evaluations of well-known attitude objects. We address this question by examining whether the acquisition of negative information changes implicit evaluations of a well-known positive historic figure: Mahatma Gandhi. We report three experiments showing rapid changes in implicit evaluations of Gandhi as measured with an affect misattribution procedure and evaluative priming task but not with an implicit association test (IAT). These findings suggest that implicit evaluations based on deep-rooted representations are subjective to rapid changes in the face of expectancy-violating information while pointing to limitations of the IAT for assessing such changes.
Heart and Beyond: Following Emotion Farther Out

Field: Arts and Humanities (Social Sciences)

Abstract Urgent times such as ours call for a reexamination of human emotional life, a life we tend to take for granted in calmer times. Philosophy, and phenomenology in particular, should have something to say about our emotional bearings or their lack in this dürftiger Zeit , a time of collective crisis and personal desperation. My hope is that a careful assessment of emotion will be of value to those of us living through what Hannah Arendt called “dark times.” As a phenomenologist, my aim is a mainly descriptive one that seeks to arrive at a more precise sense of the emergence of emotion, not as construed causally but as felt experientially . Accordingly, I shall pursue the paths traced by certain manifestations of emotion: paths that have been largely neglected in recent treatments. Being on this road (and there is no other) amounts to living with the consequences of the manifestation of emotions, what I have come to call them periphaneity .
The short isoform of PML‐RARα activates the NRF2/HO‐1 pathway through a direct interaction with NRF2

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The NF ‐E2 p45‐related factor 2 ( NRF 2)–Kelch‐like ECH ‐associated protein 1 signaling pathway plays an important role in cytoprotection. In acute promyelocytic leukemia, fusion of the promyelocytic leukemia protein ( PML ) with retinoic acid receptor alpha ( RAR α) results in an oncogene, PML ‐ RAR α ( PR ). Although previous studies have shown that both RAR α and PML inhibit NRF 2 activity, how PR regulates NRF 2 has not been reported. Here, we discovered that PR ‐S, the short isoform of PR , potentiates NRF 2 activity in a tert‐butylhydroquinone ( tBHQ ) concentration‐dependent manner. Furthermore, PR ‐S colocalized with NRF 2 in HeLa and HEK 293T cells. The association of PR ‐S and NRF 2 is mediated by the DNA ‐binding domains of RAR α and the Neh7 domain of NRF 2. Our results define a novel function of PR ‐S as a NRF 2‐transcriptional co‐activator.
Understanding the genetic architecture of human retinal degenerations

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Structures from the Stone Age can provide unique insights into Late Glacial and Mesolithic cultures around the Baltic Sea. Such structures, however, usually did not survive within the densely populated Central European subcontinent. Here, we ...The Baltic Sea basins, some of which only submerged in the mid-Holocene, preserve Stone Age structures that did not survive on land. Yet, the discovery of these features is challenging and requires cross-disciplinary approaches between archeology and ...
2023/21 Politically elected sector convenor of a trade union was protected against age discrimination (DK)

Field: Social Sciences (Social Sciences)

2023/21 Politically elected sector convenor of a trade union was protected against age discrimination (DK) Following the ECJ’s preliminary ruling in case C-587/20, the Danish Eastern High Court has ruled that a politically elected sector convenor of a trade union was protected against discrimination on the grounds of age under the Danish Anti-Discrimination Act.
Flight investigation of the effect of control centering springs on the apparent spiral stability of a personal-owner airplane

Field: Engineering (Physical Sciences)

Report presents the results of a flight investigation conducted on a typical high-wing personal-owner airplane to determine the effect of control centering springs on apparent spiral stability. Apparent spiral stability is the term used to describe the spiraling tendencies of an airplane in uncontrolled flight as affected both by the true spiral stability of the perfectly trimmed airplane and by out-of-trim control settings. Centering springs were used in both the aileron and rudder control systems to provide both a positive centering action and a means of trimming the airplane.
Segregation of molecules at cell division reveals native protein localization

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

We introduce a nonintrusive method exploiting single-cell variability after cell division to validate protein localization. We found that Clp proteases, widely reported to form biologically relevant foci, were uniformly distributed in Escherichia coli cells, and that many commonly used fluorescent proteins caused severe mislocalization when fused to homo-oligomers. Retagging five other reportedly foci-forming proteins with the most monomeric fluorescent protein tested suggests that the foci were caused by the fluorescent tags.
Performance Analysis of Magnetic Nanoparticles during Targeted Drug Delivery: Application of OHAM

Field: Engineering (Physical Sciences)

In recent years, the emergence of nanotechnology experienced incredible development in the field of medical sciences. During the past decade, investigating the characteristics of nanoparticles during fluid flow has been one of the intriguing issues. Nanoparticle distribution and uniformity have emerged as substantial criteria in both medical and engineering applications. Adverse effects of chemotherapy on healthy tissues are known to be a significant concern during cancer therapy. A novel treatment method of magnetic drug targeting (MDT) has emerged as a promising topical cancer treatment along with some attractive advantages of improving efficacy, fewer side effects, and reduce drug dose. During magnetic drug targeting, the appropriate movement of nanoparticles (magnetic) as carriers is essential for the therapeutic process in the blood clot removal, infection treatment, and tumor cell treatment. In this study, we have numerically investigated the behavior of an unsteady blood flow infused with magnetic nanoparticles during MDT under the influence of a uniform external magnetic field in a micro-tube. An optimal homotopy asymptotic method (OHAM) is employed to compute the governing equation for unsteady electromagnetohydrodynamics flow. The influence of Hartmann number (Ha), particle mass parameter (G), particle concentration parameter (R), and electro-osmotic parameter (k) is investigated on the velocity of magnetic nanoparticles and blood flow. Results obtained show that the electro-osmotic parameter, along with Hartmann’s number, dramatically affects the velocity of magnetic nanoparticles, blood flow velocity, and flow rate. Moreover, results also reveal that at a higher Hartman number, homogeneity in nanoparticles distribution improved considerably. The particle concentration and mass parameters effectively influence the capturing effect on nanoparticles in the blood flow using a micro-tube for magnetic drug targeting. Lastly, investigation also indicates that the OHAM analysis is efficient and quick to handle the system of nonlinear equations.
Drug Interactions in Patients on Long-term Oral Anticoagulant and Antihypertensive Adrenergic Neuron-blocking Drugs

Field: Medicine (Health Sciences)

The occurrence of drug interactions was studied in outpatients on anticoagulant or adrenergic neuron-blocking drugs. In the anticoagulant group (254 patients) a theoretical potential drug interaction with warfarin was noted in 33% of patients with drugs supplied by prescription and in 30% of patients with drugs taken as self-medication, though a probable adverse drug interaction was documented in only 9% of patients. The deficiency in the transfer of information about current drug therapy and the lack of awareness of patients about the hazards of anticoagulant therapy was clear.In the 64 patients on the adrenergic neuron-blocking drugs guanethidine, bethanidine, or debrisoquine a theoretical potential drug interaction was noted in 34%, but a probable adverse drug interaction was documented in only three patients. Further studies are required of other well-recognized groups of patients on drugs which are known to interact to assess the relevance and clinical importance of the formidable lists of interactions which are now available to doctors who prescribe drugs.
Integrating\nCRISPR-Cas12a into a Microfluidic Dual-Droplet\nDevice Enables Simultaneous Detection of HPV16 and HPV18

Field: Medicine (Health Sciences)

Fast, simplified, and multiplexed detection of human\npapillomaviruses\n(HPVs) is of great importance for both clinical management and population\nscreening. However, current HPV detection methods often require sophisticated\ninstruments and laborious procedures to detect multiple targets. In\nthis work, we developed a simple microfluidic dual-droplet device\n(M-D3) for the simultaneous detection of HPV16 and HPV18 by combining\nthe CRISPR-Cas12a system and multiplexed recombinase polymerase amplification\n(RPA) assay. A new approach of combining pressure/vacuum was proposed\nfor efficient droplet generation with minimal sample consumption.\nTwo groups of droplets that separately encapsulate the relevant Cas12a/crRNA\nand the fluorescent green or red reporters are parallelly generated,\nfollowed by automatic imaging to discriminate the HPV subtypes based\non the specific fluorescence of the droplets. The M-D3 platform performs\nwith high sensitivity (∼0.02 nM for unamplified plasmids) and\nspecificity in detecting HPV16 and HPV18 DNA. By combining the RPA\nand Cas12a assay, M-D3 allows on-chip detection of HPV16 and HPV18\nDNA simultaneously within 30 min, reaching a detection limit of 10<sup>–18</sup> M (∼1 copy/reaction). Moreover, the outstanding\nperformance of M-D3 was validated in testing 20 clinical patient samples\nwith HPV infection risk, showing a sensitivity of 92.3% and a specificity\nof 100%. By integrating the dual-droplet generator, CRISPR-Cas12a,\nand multiplexed RPA, the M-D3 platform provides an efficient way to\ndiscriminate the two most harmful HPV subtypes and holds great potential\nin the applications of multiplexed nucleic acid testing.
Cooperative Control Strategy of Fundamental Frequency Modulation-Based Current Source Converters for Offshore Wind Farms

Field: Energy (Physical Sciences)

The actively commutated current source converter (CSC) does not need large energy storage capacitors and can realize the black start of wind farms, which provides a practicable scheme for the lightweight offshore wind power DC transmission system. However, resulted from utilizing pulse width modulation, the existing CSC has the disadvantages of high DC harmonics and high switching loss. To solve this problem, an offshore wind power transmission system based on the current source converter with fundamental frequency modulation employed (FFM-CSC) is investigated. Firstly, the topology and mathematical model are analyzed. Then, a steady-state control strategy coordinated by the offshore CSC and the onshore CSC is put forward, and the power operating range is researched. A black start control strategy for wind farms is also proposed. Finally, the offshore wind power transmission system is tested by simulation in PSCAD/EMTDC. The results demonstrate that the FFM-CSC-based offshore wind power transmission system can smoothly realize the black start, stably control the frequency and amplitude of AC voltage, adapt to output changes of wind turbines, and realize the fault ride-through.
Traumatic Brain Injury and Posttraumatic Stress Disorder: Comorbid Consequences of War

Field: Medicine (Health Sciences)

Scientific literature is reviewed supporting a “consequence of war syndrome (CWS)” in Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn soldiers. CWS constituents include chronic pain and insomnia, other physical complaints, posttraumatic stress disorder (PTSD), anxiety, depression, and neuropsychological deficits. The foundation of CWS lies with the chronic stressors inherent to deployment and the cascade of biological events mediated and maintained by hypothalamic-pituitary-adrenal (HPA) axis dysregulation. Such dysregulation is modified by the individual’s specific experiences at war, difficulty reintegrating to post-deployment life, and the onset or exacerbation of the chronic and comorbid physical, emotional, and cognitive disorders. The circuit network between the prefrontal cortex (PFC), amygdala, and hippocampus is particularly sensitive to the consequences of war. The review’s specific conclusions are as follows: HPA axis dysregulation contributes to the chronic insomnia and hyperarousal seen in soldiers. There is considerable symptom overlap between PTSD and blast-related head injury, and it is difficult to determine the relative contributions of the two disorders to abnormal imaging studies. In some cases, traumatic brain injury (TBI) may directly precipitate PTSD symptoms. While not intuitive, the relationship between TBI and postconcussion syndrome appears indirect and mediated through PTSD. Blast-related or conventional head injury may have little long-term impact on neuropsychological functioning; contrarily, PTSD particularly accounts for current cognitive deficits. The psychological experience of CWS includes a “war-within” where soldiers continue to battle an internalized enemy. Successful treatment of CWS entails transdisciplinary care that addresses each of the constituent disorders.
Redundancy and Synchronisation Management in Mission- and Time-Critical Wireless Sensor Networks

Field: Computer Science (Physical Sciences)

Wireless sensor networks (WSNs) are a technology that has been increasingly adopted thanks to their ability to inexpensively and safely gather information in difficult-to-access environments. Because of this they are an invaluable tool to gather knowledge about health, usage, and performance parameters of products in any environment as well as identify the onset of, and avoid or mitigate, catastrophic failures. This chapter will introduce the benefits that WSNs can bring to the process of knowledge management for the development and maintenance of products as well as discuss emerging research trends regarding two prominent concerns inherent to WSNs: redundancy management and synchronisation. After reviewing these results, their impact and applicability to mission-critical applications will be discussed, as well as the interaction between the solutions.
Data from Tumor-Produced Interleukin-8 Attracts Human Myeloid-Derived Suppressor Cells and Elicits Extrusion of Neutrophil Extracellular Traps (NETs)

Field: Medicine (Health Sciences)

<div>Abstract<p><b>Purpose:</b> Myeloid-derived suppressor cells (MDSC) are considered an important T-cell immunosuppressive component in cancer-bearing hosts. The factors that attract these cells to the tumor microenvironment are poorly understood. IL8 (CXCL8) is a potent chemotactic factor for neutrophils and monocytes.</p><p><b>Experimental Design:</b> MDSC were characterized and sorted by multicolor flow cytometry on ficoll-gradient isolated blood leucokytes from healthy volunteers (<i>n</i> = 10) and advanced cancer patients (<i>n</i> = 28). In chemotaxis assays, sorted granulocytic and monocytic MDSC were tested in response to recombinant IL8, IL8 derived from cancer cell lines, and patient sera. Neutrophil extracellular traps (NETs) formation was assessed by confocal microscopy, fluorimetry, and time-lapse fluorescence confocal microscopy on short-term MDSC cultures.</p><p><b>Results:</b> IL8 chemoattracts both granulocytic (GrMDSC) and monocytic (MoMDSC) human MDSC. Monocytic but not granulocytic MDSC exerted a suppressor activity on the proliferation of autologous T cells isolated from the circulation of cancer patients. IL8 did not modify the T-cell suppressor activity of human MDSC. However, IL8 induced the formation of NETs in the GrMDSC subset.</p><p><b>Conclusions:</b> IL8 derived from tumors contributes to the chemotactic recruitment of MDSC and to their functional control. <i>Clin Cancer Res; 22(15); 3924–36. ©2016 AACR</i>.</p></div>
Chemical Modification of Lipase for Rational Enhancement of Enantioselectivity

Field: Chemistry (Physical Sciences)

Abstract Chemical modifications of the I287C mutant of a Burkholderia cepacia lipase afforded various I287C-X conjugates, among which I287C-PAA bearing an N-phenylacetamide (PAA) moiety showed excellent enantioselectivity and catalytic activity for secondary alcohols. Site-directed chemical modifications are powerful tools to control enantioselective biocatalysis.
Wear behavior of Si<sub>3</sub>N<sub>4</sub> Reinforced AA2219 Metal Matrix Composites

Field: Materials Science (Physical Sciences)

In today’s manufacturing industries, Metal Matrix Composites (MMCs) are in high demand owing to their valuable properties like high strength-to-weight ratio and resistance against wear. This research evaluates the wear properties of AA2219 matrix composites reinforced using varying amounts (2%, 4% and 6% by weight) of Si3N4 particles, fabricated by squeeze casting. Wear performance testing of the developed Aluminium Matrix Composite (AMC) is executed by utilising pin-on-disc equipment subjected to varying conditions of load and speed. The wear rate is reported to rise with increasing normal load and sliding velocity. The study also reveals that the wear rate reduces with increasing reinforcement content.
Spatial Imaginaries and Geopolitics in US–China Rivalry

Field: Social Sciences (Social Sciences)

This introduction discusses the analytic premises of the book’s core puzzle: the variation across territories and regions of great power rivalry and cooperation in the 21st century, focusing on US–China bilateral relations. China and the US are the two most powerful state actors in the post-COVID-19 world order, with China challenging the US economically and in global financial governance through initiatives like the Belt and Road and Asian Infrastructure Investment Bank. While the US remains the biggest spender on national defense, China has made significant advancements. China is also cooperating with Russia in key voting issues in the UN Security Council, although the US is the key state actor in most intergovernmental organizations. This chapter introduces spatialization as a conceptual tool to understand the variations of US–China relations across world regions.