jimnoneill/paper-to-field-training huggingface dataset:
Constitutive nuclear NF-κB in cells of the monocyte lineage

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

In monocytes, the nuclear factor NF-kappa B has been invoked as an important transcription factor in the expression of cytokine genes, of cell-surface receptors and in the expression of human immunodeficiency virus. In such cells, DNA binding activity of NF-kappa B can be detected without intentional stimulation. In our studies, cells of the human monocytic line Mono Mac 6, cultured in medium containing fetal-calf serum and low levels of lipopolysaccharide (LPS), also exhibit such ‘constitutive’ NF-kappa B, as demonstrated by mobility-shift analysis of nuclear extracts. This nuclear NF-kappa B was still present when contaminant LPS was removed by ultrafiltration and when serum was omitted. Protein-DNA complexes of constitutive NF-kappa B are similar in mobility to the LPS-induced NF-kappa B and both are recognized by an antibody specific to the p50 subunit of NF-kappa B. By contrast, treatment of cells with pyrrolidine dithiocarbamate (PDTC) will only block LPS-induced NF-kappa B, but not the constitutive binding protein. Using LPS-free and serum-free conditions, constitutive NF-kappa B can be detected in different cell lines of the monocytic lineage (HL60, U937, THP-1, Mono Mac 1 and Mono Mac 6), but not in Molt 4 T cells or K562 stem cells. When ordered according to stage of maturation, the amount of constitutive NF-kappa B was not increased in more mature cell lines. Furthermore, when inducing differentiation in Mono Mac 6 cells, with vitamin D3, no change in constitutive or inducible NF-kappa B can be detected. Analysis of primary cells revealed substantial constitutive NF-kappa B-binding activity in blood monocytes, pleural macrophages and alveolar macrophages. The constitutive NF-kappa B appears to be functionally active, since a low level of tumour necrosis factor (TNF) transcript is detectable in monocytes, and this level can be increased by blocking transcript degradation using cycloheximide. The level of constitutive NF-kappa B in these cells is variable and is frequently found to be lower in the more mature macrophages. Constitutive NF-kappa B was not maintained by autocrine action of cytokines TNF, interleukin 6, interleukin 10, granulocyte-macrophage colony-stimulating factor or macrophage colony-stimulating factor, since neutralizing antibodies did not reduce constitutive DNA-binding activity. Furthermore, blockade of prostaglandin or leukotriene biosynthesis did not affect constitutive NF-kappa B.(ABSTRACT TRUNCATED AT 400 WORDS)
Price vs Quantity in a Dynamic Duopoly Game with Capacity Accumulation.

Field: Economics, Econometrics and Finance (Social Sciences)

We present a differential duopoly game with capacity accumulation, wherethe closed-loop memoryless Nash equilibrium collapses into the open-loop Nash equilibrium. Sy mmetric Bertrand and Cournot equilibria are observationally equivalent. This result encompasses the conclusions of the well known model Kreps and Scheinkman (1983) concerning the equivalence between the Bertrand and Cournot settings in a static two-stage game. However, in the dynamic framevork, the equilibrium outcome is different, when one firm plays à la Bertrand and the other à la Cournot. This has relevant bearings upon firms` endogenous choice of the market variable, as well as the social desirability of prices vs quantities. For some admissible parameter ranges, the conflict between private and social incentives concerning the choice between prices and quantity disappears.
Comment on “Pressure-Dependent Metallic and Superconducting Phases in a Germanium Artificial Metal”

Field: Physics and Astronomy (Physical Sciences)

A Comment on the Letter by H. B. Cui et al., Phys. Rev. Lett. 102, 237001 (2009). The authors of the Letter offer a Reply.Received 20 October 2009DOI:https://doi.org/10.1103/PhysRevLett.104.139701©2010 American Physical Society
Overweight Adolescents’ Self-Perceived Weight and Weight Control Behaviour: HBSC Study in Finland 1994–2010

Field: Health Professions (Health Sciences)

Introduction . Overweight and perception of being overweight, may lead adolescent to lose weight. The aim of the present study was to investigate overweight adolescents’ self-perceived weight, body dissatisfaction, and weight control behaviour during 1994–2010 in Finland. Methods . The country-representative, cross-sectional data of 15-year olds were obtained from the Health Behaviour in School-aged Children (HBSC) study, conducted in 1994 (; males: 48%), 1998 (; 49%), 2002 (; 50%), 2006 (; 47%), and 2010 (; 48%). Results . The majority of overweight boys (62–69%) and girls (89–100%) assessed themselves as too fat, and their body image was lower than in nonoverweight adolescents. The highest prevalence of current weight controlling was found in 2006 in males (18%) and in 2010 in females (39%). Conclusion . The phenomena were current and gender differences notable, but there was no statistically significant difference in overweight adolescents’ self-perceived weight, body dissatisfaction, or weight control behaviour between survey years.
Busy female directors: an exploratory analysis of the impact of quotas and interest groups

Field: Business, Management and Accounting (Social Sciences)

Purpose This paper aims to provide an exploratory analysis of male and female directors, comparing the case of UK FTSE 350 boards of directors for 2010–2018, with Norwegian boards from 2002 to 2018, to examine patterns of busy female directors. This paper considers the differences between the effects of interest groups’ actions and those of quotas on the emergence of busy female directors. Design/methodology/approach This paper uses a longitudinal approach, providing an examination of both non-busy directors and busy directors sitting on the boards of UK and Norwegian firms, with a focus on female directors. Drawing on methods from social network analysis, several trends and patterns are mapped for the two corporate systems. The paper tests whether the proportion of busy male directors is significantly different from the proportion of busy female directors in the two institutional settings. Findings The results show there has been an increase in the proportion of busy female directors, whereas the level of busy male directors is slightly decreasing in the UK from 2010 to 2018. In Norway, following the introduction of gender quotas on corporate boards, there has been an increase in overboarded directors, especially female directors, along with the rise of so-called “golden skirt” directors. However, when compared to the UK case, the proportion of busy male and female directors is higher, suggesting that the emergence of the golden skirts in Norway is not a result of quotas alone. Originality/value The topic of busy directors has received increased attention in recent years, yet the gender of these directors is often neglected. This paper provides an overview of the characteristics of busy female directors for large UK and Norwegian firms, presenting avenues for future research.
m6A Modified Short RNA Fragments Inhibit Cytoplasmic TLS/FUS Aggregation Induced by Hyperosmotic Stress

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Translocated in LipoSarcoma/Fused in Sarcoma (TLS/FUS) is a nuclear RNA binding protein whose mutations cause amyotrophic lateral sclerosis. TLS/FUS undergoes LLPS and forms membraneless particles with other proteins and nucleic acids. Interaction with RNA alters conformation of TLS/FUS, which affects binding with proteins, but the effect of m6A RNA modification on the TLS/FUS–RNA interaction remains elusive. Here, we investigated the binding specificity of TLS/FUS to m6A RNA fragments by RNA pull down assay, and elucidated that both wild type and ALS-related TLS/FUS mutants strongly bound to m6A modified RNAs. TLS/FUS formed cytoplasmic foci by treating hyperosmotic stress, but the cells transfected with m6A-modified RNAs had a smaller number of foci. Moreover, m6A-modified RNA transfection resulted in the cells obtaining higher resistance to the stress. In summary, we propose TLS/FUS as a novel candidate of m6A recognition protein, and m6A-modified RNA fragments diffuse cytoplasmic TLS/FUS foci and thereby enhance cell viability.
Cost of introducing and delivering malaria vaccine (RTS,S/AS01E) in areas of seasonal malaria transmission, Mali and Burkina Faso

Field: Health Professions (Health Sciences)

Background The WHO recommends use of the RTS,S/AS01 E (RTS,S) malaria vaccine for young children living in areas of moderate to high Plasmodium falciparum malaria transmission and suggests countries consider seasonal vaccination in areas with highly seasonal malaria. Seasonal vaccination is uncommon and may require adaptations with potential cost consequences. This study prospectively estimates cost of seasonal malaria vaccine delivery in Mali and Burkina Faso. Methods Three scenarios for seasonal vaccine delivery are costed (1) mass campaign only, (2) routine Expanded Programme on Immunisation (EPI) and (3) mixed delivery (mass campaign and routine EPI)), from the government’s perspective. Resource use data are informed by previous new vaccine introductions, supplemented with primary data from a sample of health facilities and administrative units. Findings At an assumed vaccine price of US $5 per dose, the economic cost per dose administered ranges between $7.73 and $8.68 (mass campaign), $7.04 and $7.38 (routine EPI) and $7.26 and $7.93 (mixed delivery). Excluding commodities, the cost ranges between $1.17 and $2.12 (mass campaign), $0.48 and $0.82 (routine EPI) and $0.70 and $1.37 (mixed delivery). The financial non-commodity cost per dose administered ranges between $0.99 and $1.99 (mass campaign), $0.39 and $0.76 (routine EPI) and $0.58 and $1.28 (mixed delivery). Excluding commodity costs, service delivery is the main cost driver under the mass campaign scenario, accounting for 36% to 55% of the financial cost. Service delivery accounts for 2%–8% and 12%–23% of the total financial cost under routine EPI and mixed delivery scenarios, respectively. Conclusion Vaccine delivery using the mass campaign approach is most costly followed by mixed delivery and routine EPI delivery approaches, in both countries. Our cost estimates provide useful insights for decisions regarding delivery approaches, as countries plan the malaria vaccine rollout.
Phase Diagram of the Quaternary System Sodium Sulfate + Sodium Chloride + Hydrogen Peroxide + Water and Its Subsystems:  Experimental Data

Field: Chemistry (Physical Sciences)

Phase diagrams of the quaternary system sodium sulfate + sodium chloride + hydrogen peroxide + water and its subsystems sodium chloride + hydrogen peroxide + water, sodium sulfate + hydrogen peroxide + water, and sodium sulfate + sodium chloride + water were studied at a temperature of 288.15 K using the moist method. In this paper, the solubility data, the densities, and the refractive indexes of the liquid phase of the quaternary system and its subsystems were measured. The phase diagrams of these systems were constructed, and there are four solid phases in the diagrams. The quaternary phase diagram includes two cosatured points, five univariant curves, and four crystallization regions corresponding to NaCl, Na2SO4·10H2O, Na2SO4·0.5H2O2·H2O, and 4Na2SO4·2H2O2·NaCl.
Relevansi Nilai PSAK 73: Studi Pasar Modal Indonesia

Field: Business, Management and Accounting (Social Sciences)

Accounting standard and treatment for leasing is one that draws a lot of debate. Accounting treatment for leasing in PSAK 30 causes off-balance sheet transactions, where assets and liabilities of a leasing transaction are not recorded on financial statements. PSAK 73 introduces Right-of-Use model that could reflect leasing transactions on financial statements. This introduction is expected to increase the value relevance of financial statement for its users. Does PSAK 73 truly increase value relevance of financial statements? The authors answered the question by performing empirical research of value relevance in Indonesian Stock Exchange, especially constituents of Kompas 100 index, using Ohlson (1995) model. Authors found that contrary to expectation, PSAK 73 does not necessarily increase value relevance of financial statements for its users Although, it’s indicated that its relevance depend on the intensity of lease transactions to the company’s business. Authors discussed findings, along with recommendations for future research. Standar dan perlakuan akuntansi sewa adalah standar yang menuai banyak perdebatan. Perlakuan akuntansi sewa dalam PSAK 30 membuat adanya transaksi off-balance sheet dimana aset dan liabilitas dari suatu transaksi tidak tercatat dalam laporan keuangan. PSAK 73 memperkenalkan model Right-of-Use yang dapat merefleksikan transaksi sewa dalam laporan keuangan. Hal ini diharapkan akan meningkatkan relevansi laporan keuangan bagi penggunanya. Apakah PSAK 73 benar meningkatkan relevansi laporan keuangan? Penulis menjawab hal tersebut dengan melakukan penelitian empiris relevansi nilai di pasar modal Indonesia, terutama perusahaan konstituen Kompas 100, menggunakan model Ohlson (1995). Penulis menemukan bahwa bertentangan dengan ekspektasi, PSAK 73 tidak serta merta meningkatkan relevansi nilai laporan keuangan bagi penggunanya. Meski begitu, terindikasikan bahwa relevansi nilai PSAK 73 bergantung pada intensitas transaksi sewa bagi bisnis perusahaan. Penulis mendiskusikan temuannya, beserta dengan rekomendasi untuk penelitian selanjutnya
The Role of Thermal Feedback in the Growth of Planetary Cores by Pebble Accretion in Dust Traps

Field: Physics and Astronomy (Physical Sciences)

High-resolution millimetre-imaging of protoplanetary discs has revealed many containing rings and gaps. These rings can contain large quantities of dust, often in excess of 10M$_\oplus$, providing prime sites for efficient and rapid planet formation. Rapid planet formation will produce high accretion luminosities, heating the surrounding disc. We investigate the importance of a planetary embryo's accretion luminosity by simulating the dynamics of the gas and dust in a dust ring, accounting for the energy liberated as a resident planetary embryo accretes. The resulting heating alters the flow structure near the planet, increasing the accretion rate of large, millimetre-to-centimetre-sized dust grains. We show how this process varies with the mass of dust in the ring and the local background gas temperature, demonstrating that the thermal feedback always acts to increase the planet's mass. This increase in planet mass is driven primarily by the formation of vortices, created by a baroclinic instability once the accreting planet heats the disc significantly outside its Hill radius. The vortices can then migrate with respect to the planet, resulting in a complex interplay between planetary growth, gap-opening, dust trapping and vortex dynamics. Planets formed within dust traps can have masses that exceed the classical pebble isolation mass, potentially providing massive seeds for the future formation of giant planets. Once pebble accretion ceases, the local dust size distribution is depleted in large grains, and much of the remaining dust mass is trapped in the system's L$_5$ Lagrange point, providing potentially observable signatures of this evolution.
Clinical implications of accessory fallopian tube ostium in endometriosis and primary infertility

Field: Medicine (Health Sciences)

Several variations in fallopian tube anatomy may be noted during the evaluation of infertility. Some anatomical variants such as accessory tubal ostia are rare. A 31-year-old woman presented to our center with a 2-year history of primary infertility. Given her history of dysmenorrhea, a diagnostic laparoscopy was performed. Laparoscopy revealed a left utero-sacral endometriosis implant, which was resected. Although the left fallopian tube was normal, the right fallopian tube was noted to have two prongs with individual ostia. Tubal cannulation confirmed two separate ostia, with chromotubation showing free flow of dye through separate fimbrial ostia of the right fallopian tube. The current case highlights that accessory tubal ostia are rare müllerian duct anomalies seen during laparoscopy and can be associated with endometriois or primary infertility.
Comparison of β‐adrenoceptors mediating vasodilatation in canine subcutaneous adipose tissue and skeletal muscle

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Blood flow changes in response to various drugs in simultaneously autoperfused canine subcutaneous adipose tissue and gracilis muscle were compared to study the vascular β‐adrenoceptors. Compared to isoprenaline the β 2 ‐selective agonist salbutamol was 4–6 times more potent as a vasodilator in the muscle than in adipose tissue. Furthermore two β 1 ‐selective agonists (Tazolol and H80/62) caused vasodilatation in adipose tissue but not in the gracilis muscle. When given by close i.a. injection after β‐adrenoceptor blockade, adrenaline was a more potent vasoconstrictor than noradrenaline in both tissues. Before β‐blockade, however, noradrenaline was the more potent vasoconstrictor in the gracilis muscle whereas adrenaline was more potent in adipose tissue. Intravenous infusion of adrenaline in doses causing vasodilatation in the muscle caused vasoconstriction in adipose tissue whereas intravenous infusion of noradrenaline caused vasoconstriction in both tissues. The present findings suggest that the β‐adrenoceptors mediating vasodilatation in skeletal muscle are mainly of the β 2 ‐type, whereas β 1 ‐adrenoceptors seem to predominate in subcutaneous adipose tissue. Since adrenaline is a much more potent β 2 ‐ than β 1 ‐agonist, these differences point to different roles of intravascular adrenaline in the two sites. In skeletal muscle circulating adrenaline is mainly a vasodilator whereas in subcutaneous adipose tissue it mainly acts as a vasoconstrictor.
PC-SENE: A node embedding based method for protein complex detection

Field: Computer Science (Physical Sciences)

With the accumulation of protein-protein interaction (PPI) datasets, various computational methods have been developed for identifying protein complexes from PPI networks. However, many exiting computational methods have their own limitations: supervised learning approaches need tedious effort for feature engineering and the quality measures used to guide the mining process of unsupervised methods have some drawbacks in reflecting the properties of a protein complex in PPI networks. In this work, we proposed a novel protein complex detection method, named PC-SENE. For given seeds, it uses alias sampling strategy based on protein node embedding similarities to select potential addable nodes, and makes use of a new conductance measure to decide whether to extend current candidate subgraph in order to find protein complexes. Intuitively, a well trained node embedding vector could preserve both the topological characteristics of the PPI network and the diversity of connectivity patterns of nodes in the network, and thus node embedding similarities can better reflect the relationship between nodes. The experimental results show the robustness and effectiveness of PC-SENE.
Objects in Mirror Are Closer Than They Appear

Field: Arts and Humanities (Social Sciences)

September 01 2016 Objects in Mirror Are Closer Than They Appear Chloë Rae Edmonson Chloë Rae Edmonson Chloë Rae Edmonson is a PhD candidate in Theatre at The Graduate Center, CUNY and a Theatre instructor at the City College of New York. Her dissertation investigates drinking culture and the “experience economy” within immersive theatre and popular entertainments in New York City since the mid-nineteenth century. She holds an MA in Performance Studies from NYU Tisch School of the Arts (Wasserman Scholar) and a BA in Drama and English from Trinity University in San Antonio, Texas. Search for other works by this author on: This Site Google Scholar Author and Article Information Chloë Rae Edmonson Chloë Rae Edmonson is a PhD candidate in Theatre at The Graduate Center, CUNY and a Theatre instructor at the City College of New York. Her dissertation investigates drinking culture and the “experience economy” within immersive theatre and popular entertainments in New York City since the mid-nineteenth century. She holds an MA in Performance Studies from NYU Tisch School of the Arts (Wasserman Scholar) and a BA in Drama and English from Trinity University in San Antonio, Texas. Online Issn: 1537-9477 Print Issn: 1520-281X © 2016 Performing Arts Journal, Inc.2016 PAJ: A Journal of Performance and Art (2016) 38 (3 (114)): 51–57. https://doi.org/10.1162/PAJJ_a_00334 Cite Icon Cite Permissions Share Icon Share Facebook Twitter LinkedIn MailTo Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation Chloë Rae Edmonson; Objects in Mirror Are Closer Than They Appear. PAJ: A Journal of Performance and Art 2016; 38 (3 (114)): 51–57. doi: https://doi.org/10.1162/PAJJ_a_00334 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPAJ: A Journal of Performance and Art Search Advanced Search This content is only available as a PDF. © 2016 Performing Arts Journal, Inc.2016 Article PDF first page preview Close Modal You do not currently have access to this content.
Social Psychology of Psychologists: Volunteer vs Nonvolunteer Therapists

Field: Psychology (Social Sciences)

External validity is questionable whenever generalizations are made over any facet sampled selectively in a design, including experimenters. Sampling experimenters selectively is particularly common in research on outcome of therapy in which typically only volunteer therapists are included. Using archival data capturing a 6-mo. period, the present study yielded differences between therapists who did ( n = 5) and did not ( n = 9) volunteer to serve as experimenters in a study of outcome on three variables, number of “no show” clients, average total number of sessions clients were seen, and age of experimenter. These findings suggest the importance of considering hidden interactions between therapist volunteer status and experimental treatments, interactions which would limit the external validity of results of study of outcome.
<sc>Supervision in the Changing Field of Social Work</sc>. By Sidney S. Eisenberg. Philadelphia: The Jewish Family Service (in association with the University of Pennsylvania School of Social Work), 1956. 88 pp. $2.00

Field: Social Sciences (Social Sciences)

Supervision in the Changing Field of Social Work. By Sidney S. Eisenberg. Philadelphia: The Jewish Family Service (in association with the University of Pennsylvania School of Social Work), 1956. 88 pp. $2.00 Get access Eisenberg Sidney S.Supervision in the Changing Field of Social Work 1956Philadelphia The Jewish Family Service (in association with the University of Pennsylvania School of Social Work)$2.0088 Helen Harris Perlman Helen Harris Perlman University of Chicago, School of Social Service Administration Search for other works by this author on: Oxford Academic PubMed Google Scholar Social Work, Volume 2, Issue 2, April 1957, Page 106, https://doi.org/10.1093/sw/2.2.106 Published: 01 April 1957