jimnoneill/paper-to-field-training huggingface dataset:
Pattern of Recurrence of Glioblastoma Versus Grade 4 IDH-Mutant Astrocytoma Following Chemoradiation: A Retrospective Matched-Cohort Analysis

Field: Medicine (Health Sciences)

Background and Purpose: To quantitatively compare the recurrence patterns of glioblastoma (isocitrate dehydrogenase-wild type) versus grade 4 isocitrate dehydrogenase-mutant astrocytoma (wild type isocitrate dehydrogenase and mutant isocitrate dehydrogenase, respectively) following primary chemoradiation. Materials and Methods: A retrospective matched cohort of 22 wild type isocitrate dehydrogenase and 22 mutant isocitrate dehydrogenase patients were matched by sex, extent of resection, and corpus callosum involvement. The recurrent gross tumor volume was compared to the original gross tumor volume and clinical target volume contours from radiotherapy planning. Failure patterns were quantified by the incidence and volume of the recurrent gross tumor volume outside the gross tumor volume and clinical target volume, and positional differences of the recurrent gross tumor volume centroid from the gross tumor volume and clinical target volume. Results: The gross tumor volume was smaller for wild type isocitrate dehydrogenase patients compared to the mutant isocitrate dehydrogenase cohort (mean ± SD: 46.5 ± 26.0 cm 3 vs 72.2 ± 45.4 cm 3 , P = .026). The recurrent gross tumor volume was 10.7 ± 26.9 cm 3 and 46.9 ± 55.0 cm 3 smaller than the gross tumor volume for the same groups ( P = .018). The recurrent gross tumor volume extended outside the gross tumor volume in 22 (100%) and 15 (68%) ( P= .009) of wild type isocitrate dehydrogenase and mutant isocitrate dehydrogenase patients, respectively; however, the volume of recurrent gross tumor volume outside the gross tumor volume was not significantly different (12.4 ± 16.1 cm 3 vs 8.4 ± 14.2 cm 3 , P = .443). The recurrent gross tumor volume centroid was within 5.7 mm of the closest gross tumor volume edge for 21 (95%) and 22 (100%) of wild type isocitrate dehydrogenase and mutant isocitrate dehydrogenase patients, respectively. Conclusion: The recurrent gross tumor volume extended beyond the gross tumor volume less often in mutant isocitrate dehydrogenase patients possibly implying a differential response to chemoradiotherapy and suggesting isocitrate dehydrogenase status might be used to personalize radiotherapy. The results require validation in prospective randomized trials.
Children's Socio-Emotional Development and Adjustment: Role of Maternal Trauma, Mentalization and Parenting Style

Field: Psychology (Social Sciences)

The present study examined the links between children's socio-emotional functioning and adjustment problems, and maternal mentalization, parenting style, and history of trauma. Participants were 75 mothers and their children age 6-12 years (43 males and 32 females). Mothers' reports of their childhood trauma, mentalization capacity, symptoms of post-traumatic stress and depression, and emotion-related parenting style were obtained along with their reports of their children's social and emotional skills and emotional and behaviour problems. Children completed tasks that assessed their mentalization ability. Children also completed reports of their emotional intelligence and trauma symptoms. Maternal history of emotional abuse significantly predicted maternal depression, and maternal history of sexual abuse significantly predicted maternal PTSD symptoms. Maternal depression and PTSD were both significantly related to children's social skills, and children's internalizing and externalizing problems. Maternal mentalization was significantly associated with children's internalizing and externalizing behavior problems, and children's social skills. After controlling for the effects of a history of maternal psychotherapy, maternal mentalization partially mediated the relationship between maternal PTSD symptoms and children's internalizing problems, and maternal mentalization fully mediated the relationship between maternal PTSD symptoms and children's social skills. Emotion-coaching parenting style did not mediate the relationship between maternal trauma and children's adjustment, however, parental uncertainty and ineffectiveness in emotion socialization were significantly associated with both maternal PTSD symptoms and children's internalizing and externalizing problems. These findings highlight the importance of maternal mentalization as an explanatory mechanism in the intergenerational transmission of trauma, and emphasize the need for early intervention and prevention efforts, which focus on bolstering mentalization abilities for traumatized mothers in a parenting role.
Molecular Structures and Electronic Structures of Transition-Metal Mixed-Sandwich Complexes, [CpFe(II)(PhX)](+1) and Ferrocene

Field: Chemistry (Physical Sciences)

The local structures of the transition-metal mixed-sandwich complexes, [CpFe(II)(PhX)](+1). (Cp =η 5 -cyclopentadienyl; PhX =η 6 -benzene and its derivatives), have been studied by EXAFS and density-functional theory (DFT). Fe K-edge EXAFS spectra were measured at 10K and analysed by a two-shell model, and DFT calculations were made to predict more detailed molecular structures. Both methods give the Fe-C distance of ferrocene in good agreement with electron diffraction in gas phase. For the mixed-sandwich complexes, EXAFS and DFT provide similar structures that the Fe-C distance in the Ph-pyramid is slightly longer than that in the Cp-pyramid for all the derivatives except the [CpFe(C 6 (CH 3 ) 6 )](+) complex. It is found by DFT that the Fe-C(X) distance in the PhX-pyramid changes depending on whether the substituent X is an electron donnor or an electron acceptor. We discuss the dependence from the valence MO's and the Mulliken population analysis.
A Case of Possible Hypersensitivity Reactions to Human Insulin

Field: Medicine (Health Sciences)

Abstract Background: Insulin therapy is commonly used in diabetic patients. It represents the only option for patients with type 1 diabetes mellitus and could be part of the treatment plan for the patient with type 2 diabetes mellitus. Clinical appearance of hypersensitivity reactions to insulin vary significantly, depending on the immune mechanism involved. Many skin prick tests could be interpreted as positive reactions (either by using inappropriate concentrations or due to other mast cell degranulation causes). Case History: Four weeks after initiation of insulin therapy, patient V.I. experienced a maculopapular rash, severe pruritus, induration at the injection site after 12-24 hours after administration. The presence of an insulin sensitization was proven by skin prick test and determination of specific IgE. Discussions: Patients suspected of insulin hypersensitivity should be evaluated by an allergologist in order to obtain a correct diagnosis and to identify other possible causes for the insulin intolerance. Desensitization should be undertaken only in real insulin hypersensitivity cases in patients who need it. Conclusions: Insulin allergy can be managed successfully with a good cooperation between the diabetologist and the allergologist.
[Simultaneous myocardial revascularization and abdominal aortic aneurysm repair (report of a fatal case)].

Field: Medicine (Health Sciences)

Patients with coronary disease associated with abdominal aortic aneurysm or aortoiliac occlusive disease often raise problems of operative strategy. In particular, the order in which these lesions should be treated is a frequent source of controversy. Our approach for the past two years has been a combined myocardial revascularization with abdominal aortic reconstruction in patients with both lesions. From 1999 through 2001 seven patients underwent combined abdominal aortic reconstruction with coronary artery bypass grafting. We report here the fatal case of combined coronary artery bypass grafting and abdominal aortic aneurysm repair. Partial heparinization and operation without extracorporeal circulation caused acute thrombosis of abdominal aortic aneurysm and femoral arteries. Our first experience advocates using total heparinisation and cardiopulmonary bypass for combined cardiac-aortic procedures.
Complete Genome Sequence of Enterotoxigenic Escherichia coli Myophage LL12

Field: Immunology and Microbiology (Life Sciences)

This work describes the complete genome sequence of the virulent myophage LL12. The 136-kb LL12 genome is related to coliphage V5 and is a component in the prebiotic PreforPro. LL12 was isolated against enterotoxigenic Escherichia coli , which causes traveler’s diarrhea.
Management and Outcomes of Anterior Cruciate Ligament Failure: An Observational Study

Field: Medicine (Health Sciences)

Background: Anterior cruciate ligament (ACL) injuries are prevalent among young, physically active individu-als and can significantly impair knee function. The management of ACL failures, whether through surgical or non-surgical means, presents various challenges and outcomes. Objective: This study aimed to evaluate the causes, management strategies, and outcomes of ACL failures in patients treated at a tertiary care hospital in Maharashtra, India. Methods: A retrospective observational study was conducted involving 29 patients diagnosed with ACL failure. Participants were divided into surgical (n=18) and non-surgical (n=11) management groups. Data were collected on demographic characteristics, injury mechanisms, treatment details, functional outcomes, and complications. Functional outcomes were assessed using the Lysholm Knee Score and the International Knee Documentation Committee (IKDC) subjective knee evaluation. Statistical analyses were performed to compare outcomes be-tween the two groups. Results: The mean age of participants was 30.5 years, with a higher prevalence among males (65.5%). Sports-related injuries accounted for 58.6% of cases. The surgical group showed superior functional outcomes with a mean Lysholm Knee Score of 88.2 compared to 80.4 in the non-surgical group. Similarly, the IKDC scores were higher in the surgical group (85.3 vs. 78.6). Return to pre-injury activity levels was achieved by 72.2% of surgically treated patients and 63.6% of those managed non-surgically. Complications included graft failure (11.1%) and postoperative infection (5.6%) in the surgical group. Osteoarthritis development was noted in 22.2% of the surgical group and 27.3% of the non-surgical group. Conclusion: Surgical management of ACL failures tends to result in better functional outcomes and a higher rate of return to pre-injury activity levels. However, it is associated with specific complications such as graft failure and infection. Non-surgical management, while avoiding these surgical risks, still presents significant long-term complications like osteoarthritis. These findings underscore the need for personalized treatment plans to optimize patient outcomes and manage complications effectively.
[Our experience in the poly-traumatized pediatric patient with criteria for admission to the ICU].

Field: Medicine (Health Sciences)

Mortality is higher than other series but it may be because that these series include minor injuries. The fall down is the most frequent in pediatric emergencies but it was the mechanism that involves less admission to the UCI. Both ITP as Glasgow score are good indicators of severity and if their values decrease, the hospital stay in UCI and the mortality increase.
Supplementary Figure 5 from Design of Agonistic Altered Peptides for the Robust Induction of CTL Directed towards H-2D<sup>b</sup> in Complex with the Melanoma-Associated Epitope gp100

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Supplementary Figure 5 from Design of Agonistic Altered Peptides for the Robust Induction of CTL Directed towards H-2D<sup>b</sup> in Complex with the Melanoma-Associated Epitope gp100
A Basic Research on the Development of Taekwondo Statistic & Indicators

Field: Social Sciences (Social Sciences)

이 연구에서는 세계태권도본부 국기원, 세계태권도연맹, 대한태권도협회 그리고 태권도진흥재단이 태권도에 관한 정확한 통계·지표를 생산하여 일선 지도자들과 연구자, 정책입안자, 산업 종사자들이 활용할 수 있도록 해야 한다는 당위성에서 출발하였으며, 그 결과 다음과 같은 결론을 도출할 수 있었다. 첫째, 국기원에서 생산이 가능한 통계·지표는 국가별 태권도 보급현황을 비롯하여 총 61종의 통계·지표 생산이 가능한 것으로 나타났다. 둘째, 세계태권도연맹에서 생산이 가능한 통계·지표는 랭킹 현황을 비롯하여 총 33종의 통계·지표 생산이 가능한 것으로 나타났다. 셋째, 대한태권도협회에서 생산이 가능한 통계·지표는 국내 태권도 도장 종사자 수(지역별)를 비롯하여 총 41종의 통계·지표 생산이 가능한 것으로 나타났다. 넷째, 태권도진흥재단에서 생산이 가능한 통계·지표는 태권도 진흥을 위한 각종 지원 사업 현황을 비롯하여 23종의 통계·지표 생산이 가능한 것으로 나타났다. 그러나 각 단체에서 통계·지표 생산이 원활히 이루어지기 위해서는 단체별 통계·지표의 중복 문제 해결, 전 세계의 통계자료 수집을 위한 효율적 방안 모색, 통계·지표에 기반 한 정책수립 의지가 선결되어야 한다.
The effects of a large-scale fire on the demographic structure of a population of Hermann's (Testudo hermanni boettgeri Mojsisovics, 1889) and Spur-thighed (Testudo graeca ibera Pallas, 1814) tortoises in Eastern Rhodopes Mountains, Bulgaria

Field: Agricultural and Biological Sciences (Life Sciences)

The numerous fires during the last decade in the area of Eastern Rhodopes (Southeastern Bulgaria) led to large losses of habitat for the Hermann’s (Testudo hermanni) and Spur-thighed (Testudo graeca) tortoises. The data from this study demonstrate that the fire in the vicinity of Kolets village, Haskovo district, has caused large negative impacts on the population of T. hermanni and slightly lower impacts on T. graeca. The average density of the populations of T. hermanni in the burned areas (D = 0.7 ind./ha) is 7.2 times lower than that of the control areas (D = 5.3 ind./ha). The differences in the population densities of T. graeca are smaller, but are still well pronounced -- the density for the burned area (D = 0.5 ind./ha) is 4.2 times lower than that of the control area (D = 2.0 ind./ha). The recorded mortality due to fire for T. hermanni is 64.3 %.
Treatment of human cell lines with 5-azacytidine may result in profound alterations in clonogenicity and growth rate.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Liquid medium cultures of three human cell lines (B-lymphoma, myeloma, and squamous lung carcinoma) with population-doubling times (PDT) and cloning efficiencies (CE) in the range of 32-43 h and 0.01-5.6%, respectively, were exposed to 5-azacytidine (5-azaC) for 3 d. The doses used (1-3 microM) were found to be nontoxic as measured by cell growth in liquid and semisolid agar medium and to be nonmutagenic as measured by the rate of generation of ouabain- and 6-thioguanine-resistant cell variants. After 5-azaC treatment, cell samples were subsequently harvested every day and assayed for their CE in semisolid agar medium. For each cell line, 30 to 42 individual clones were harvested at the day of maximal CE and expanded in liquid culture medium. PDT and CE were determined for each subclone about every 6 wk for 12 mo. The majority of the subclones had unaltered PDT and CE compared to the original lines. However, several clones had profoundly changed proliferative activity with PDT on approximately 12-14 h and/or CE 5 to greater than 50%. Some of the clones with altered growth properties reverted to PDT and/or CE values of untreated clones. However, a few clones of each line had stable alterations with PDT on 12-14 h and CE 5 to greater than 50%; these clones were all significantly hypomethylated. It is concluded that the human gene repertoire does contain genes that appropriately activated can result in growth properties with very short PDT and high CE (and comparable to animal cell lines), and that this activation may be obtained by 5-azaC treatment. It is conceivable that the procedure here described to alter growth properties of human cell lines may be applied to experimental situations, where alterations of cell growth properties are desired.
Screening of novel alkaloid inhibitors for vascular endothelial growth factor in cancer cells: an integrated computational approach

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Vascular endothelial growth factor (VEGF) is expressed at elevated levels by most cancer cells, which can stimulate vascular endothelial cell growth, survival, proliferation as well as trigger angiogenesis modulated by VEGF and VEGFR (a tyrosine kinase receptor) signaling. The angiogenic effects of the VEGF family are thought to be primarily mediated through the interaction of VEGF with VEGFR-2. Targeting this signaling molecule and its receptor is a novel approach for blocking angiogenesis. In recent years virtual high throughput screening has emerged as a widely accepted powerful technique in the identification of novel and diverse leads. The high-resolution X-ray structure of VEGF has paved the way to introduce new small molecular inhibitors by structure-based virtual screening. In this study using different alkaloid molecules as potential novel inhibitors of VEGF, we proposed three alkaloid candidates for inhibiting VEGF and VEGFR mediated angiogenesis. As these three alkaloid compounds exhibited high scoring functions, which also highlights their high binding ability, it is evident that these alkaloids can be taken to further drug development pipelines for use as novel lead compounds to design new and effective drugs against cancer.
E-Commerce and Privacy: Exploring What We Know and Opportunities for Future Discovery

Field: Business, Management and Accounting (Social Sciences)

Electronic commerce (e-commerce) has a built-in trade-off between the necessity of providing at least some personal information to consummate an online transaction and the risk of negative consequences from providing such information. This requirement and the increased sophistication of companies' personal information gathering have made e-commerce privacy a critical issue and have spawned a broad research literature that is reviewed in this paper. Key research issues and findings are organized, using a framework defined by four key stakeholder groups—companies, customers, privacy solution providers (PSPs), and governments—as well as the interactions among them. The review indicates that the published research on e-commerce privacy peaked in the early 2000s; thus, it has not addressed many of the technological advances and other relevant developments of the past decade. Potential research opportunities for researchers in Management Information Systems (MIS) and Accounting Information Systems (AIS) include: company privacy strategies, operations, disclosures, and compliance practices; customer privacy concerns arising from company practices such as Internet activity tracking, physical location tracking, personal information gathering by social networks, and information exchanges in cloud computing environments; privacy-enhancing technologies, controls, and assurance practices developed by PSPs; and privacy regulations relating to various industries, countries, and cultures. More use of experimental and archival research is encouraged.
Attitude control with a region-based method for an unmanned aerial vehicle

Field: Engineering (Physical Sciences)

This paper presents dynamic inversion control with a region control method. Dynamic inversion control is chosen to deal with the strong coupling effect present in an underactuated aerial vehicle (quadrotor). Dynamic inversion is effective in both linear and nonlinear control whilst the region control method is a method that can reduce the energy consumption of the quadrotor. Numerical simulations are presented to demonstrate the effectiveness of the proposed controller.
Shadow economy and foreign direct investment in Nigerian manufacturing industry

Field: Economics, Econometrics and Finance (Social Sciences)

In this paper, we investigate the symmetric and asymmetric effect of shadow economy on foreign direct investment (FDI) in Nigerian manufacturing sector using ARDL and NARDL estimation techniques for the period of 1975-2017. We find that an increase in shadow economy reduces FDI net inflow in the short run while this relationship turns to be positive in the long run. This result persists after using NARDL to re-estimate the model. Negative and positive changes in the size of shadow economy have negative and significant effects on FDI in the short run, while in the long run both changes have positive effects on FDI in the sector. The results imply that in the short run, new foreign investors would like to operate in the formal sector due to tax incentives and other financial incentives available for new entrants. However, in the long run, shadow economy attracts FDI, because incentives enjoyed have expired coupled with high cost of doing business in the country. The investors would prefer to either look for loopholes in tax laws or attempt to evade tax and cut down official remittances to the government by operating in the informal sector of the economy.
The Coins Of Herod The Great In The Context Of The Augustan Empire

Field: Arts and Humanities (Social Sciences)

Two of Herods bronze coin series are thought to relate to historical milestones in Herods relationship to Augustus. This chapter concentrates on Herods large diadem/table type, minted in Jerusalem, and his year-three coins, thought by many to have been minted in Samaria. Most of Herods coinage was struck for purely economic reasons, to make fractional currency available both for Herods standing army and for the labourers employed in his extensive building activities. The chapter considers another functionperhaps new for Judeafor the minting of the coins of Herod, as celebratory handouts, in the spirit of Roman institutions of congiaria and donativa . Herods year-three coins may also have been minted for a congiarium . If they dated, as is generally accepted, to around 37 BCE, they celebrated Herods conquest of Jerusalem. The chapter focuses on what intersections one may find between Herods coins and events relating to Augustus, or Augustan policy and iconography. Keywords: Augustan Empire; building activities; congiaria ; congiarium ; donativa ; Herods coins; iconography; Jerusalem; year-three coins
The Export-Led Growth: A Technological View

Field: Economics, Econometrics and Finance (Social Sciences)

The details of the impact of exports on economic growth have been one of the most important topics in the literature. Numerous studies asserted that open economies grow faster than the closed ones because of the effect of the exports on GDP and increase of productivity and efficiency through foreign competition. Concurrently, these studies indicated that there are strong correlation exists between exports and economic growth. On the other hand, high share of production of technology in today's economies is the key for sustainable and high rates of growth and the relationship between technology exports and economic growth has been a topic of interest among economists. Many studies in the literature published on export-led hypothesis in recent years but only few studies addressed the technological issues. Therefore, the purpose of this study is to examine the impact of technology exports on economic growth of selected OECD countries using dynamic panel method. We established the model by using the yearly data of 2003-2015 periods for selected OECD countries provided by OECD.Stat. As a conclusion, it is revealed that technology exports have positive and statistically significant impact on economic growth. These results implied that high-tech exports led to growth in selected OECD countries. These results suggested that promoting the production of technology is one the drivers of the economic growth.