jimnoneill/paper-to-field-training huggingface dataset:
Clinical observation of methylprednisolone sodium succinate for injection combined with ganciclovir in the treatment of severe viral meningitis

Field: Medicine (Health Sciences)

Objective
To investigate the value of methylprednisolone sodium succinate for injection combined with ganciclovir in the treatment of severe viral meningitis.

Methods
Ninety-eight patients with severe viral meningitis from January 2016 to February 2018 were enrolled in Shanxi Coal Central Hospital. The patients were divided into observation group and control group according to the random number table method, with 49 cases in each group. On the basis of routine treatment, the control group was treated with ganciclovir + dexamethasone, while the observation group was treated with ganciclovir + methylprednisolone sodium succinate for injection. The clinical efficacy, symptoms and signs, serum inflammatory factors [procalcitonin (PCT), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8)] levels and functional scores [neurological function (NIHSS score), motor function (Fugl-Meyer score), activity of life (ADL score) changes before and after treatment were compared between the two groups. The incidences of adverse reactions during treatment were compared between the two groups.

Results
①Clinical efficacy: the total effective rate of observation group was 91.84% (45/49), which was higher than that of control group [75.51% (37/49), P 0.05).

Conclusions
The effect of methylprednisolone sodium succinate for injection combined with ganciclovir on severe viral meningitis is remarkable, which is beneficial to alleviating clinical symptoms and signs, reducing the degree of inflammation reaction, improving the functional status of patients, with certain safety.

Key words:
Severe viral meningitis; Ganciclovir; Methylprednisolone sodium succinate for injection; Inflammatory factors; Neurological function
KOMUNIKASI LINGKUNGAN DALAM KOMUNIKASI ISLAM

Field: Social Sciences (Social Sciences)

This study needs to be studied to understand environmental communication in the concept of Islamic communication. The basic concept needs to be understood that Aceh is faced with various kinds of environmental problems that threaten the sustainability of eco-systems, biodiversity, and deterioration of environmental quality. This will also have an impact on increasing the intensity of disasters and decreasing the health quality of the community. Therefore, collective awareness is needed to save a balanced and sustainable environment. The aspect of environmental communication management is a strategic approach to building the collaboration of the parties in making people, industries, companies, governments and anyone aware of having a common awareness and strategy in the context of saving a quality, harmonious and sustainable environment. In the Islamic perspective, communication is an integral part of human life. One of the purposes of communication in Islam is to spread moral values derived from the Qur’an. In the Qur’an, it has been regulated about the procedures for how humans relate to humans and to the environment.
Relationship of callosities of the forefoot with foot deformity, Health Assessment Questionnaire Disability Index, and joint damage score in patients with rheumatoid arthritis

Field: Medicine (Health Sciences)

Objectives: We aimed to investigate the relationship of callosities of the forefoot with foot deformity, the Health Assessment Questionnaire Disability Index (HAQ-DI) and modified total Sharp score (TSS) in patients with rheumatoid arthritis (RA).Methods: A total of 202 patients and 404 feet were enrolled. We examined the prevalence of callosities. Clinical data included the HAQ-DI, TSS, hallux valgus angle (HVA), and calcaneal pitch angle (CPA). The analysis of factors associated with callosities of the forefoot was performed by comparing patients with and without callosities of the forefoot.Results: The prevalence of callosities was 31.2% of all patients and 24.0% of all feet. The patients with callosities of the forefoot had significantly higher TSS of the foot. The presence of callosities affected the HAQ-DI walking score. HVA and CPA were identified as being associated with callosities of the forefoot. Analyzing from the cutoff values, the odds ratios of HVA, CPA, and HVA and (combined) CPA were 4.64, 1.73, and 2.99, respectively.Conclusion: Hallux valgus and flatfoot were related to callosities of the forefoot in RA. This study suggested that to prevent callosities of the forefoot, early diagnosis and foot care for hallux valgus and flatfoot are needed in daily practice.
Stochastic comparisons of replacement policies in coherent systems under minimal repair

Field: Decision Sciences (Social Sciences)

Abstract In this paper, we study stochastic comparisons of the coherent systems obtained under different repair policies. We consider minimal repairs of the components, that is, a failed component is replaced by another component which is similar (ie, it has the same distribution) to the replaced one and with the same age. Under these assumptions, we study how to determine the best replacement policies. Two general methods are proposed, one for systems with identically distributed components and another one for systems with ordered (in different stochastic senses) components. Both methods can be applied to systems with independent or dependent components. We use these methods to determine the optimal repair policies in some particular cases. We pay special attention to series and parallel systems with independent or dependent components. An algorithm to find the optimal replacement policy (when it exists) is provided.
A Study on the Impact of Organizational Service Climate on Customer Experience

Field: Business, Management and Accounting (Social Sciences)

Service climate is the specific reflection of organizational climate in service and a perception shared by employees. Meanwhile, more and more scholars begin to pay more attention to customer's consumption experience. Customer's consumption process is a process of perceptional experience, but also a process of emotional experience. Service climate is a perception produced by employees on policies, procedures and management behavior of the company, employees thus perceived quality of service and provide high-performance service, influence consumption experiences of external customers and ultimately influence customer loyalty. The article firstly introduces the dimensions of service climate and customer experience based on some relevant research. Secondly, we aim to investigate the effect of organizational service climate on customer experience through developing a conceptual model. Finally, we suggest the development path of customer experience strategies through analyzing the conceptual model, to enhance company brand image and customer loyalty.
Acculturation of Javanese culture with Islamic culture in the month of Muharrom in Brayo Village Wonotunggal Batang

Field: Social Sciences (Social Sciences)

Nyadran is a series of traditional ceremonies, which are part of cultural heritage and believe that certain places are sacred or holy places. Nyadran traditions like this are a from of salvation carried out as a from of gratitude and respect for ancestors. The data collection technique used in this research was interviews with the main sources, the head of the Nyadran committee and the of Brayo village. The location of this research was in Ujung Biru Hamlet, Brayo Village, Wonotunggal District. Nyadran activities in Ujung Biru Hamlet are held in the month of Muharrom because Muharrom is not the Hijri New Year. Nyadran implementation in Brayo Village has been carried out since ancient times, as time goes by, the nyadran tradition has undergone many changes.
сисOptimization of the state information policy of Ukraine in the conditions of contemporary modernization processes

Field: Social Sciences (Social Sciences)

The article discusses the different concepts of the State information policy, its purpose and content. Notes that existing concepts, strategies, etc. in information sphere are unfortunately still fragmented (focused above all on the creation of scientific-technical and technological base of the transition to the information society, in particular through the development of information and communication infrastructure and advanced information technologies) and the lack of systematic integrity of regulatory documents. According to this, in all of greater relevance is the question of development and approval of Unified Code of public documents regarding the management sphere. The strategic weight of today become the issue of legislative regulation of various aspects of its development of information-communicative sphere of Ukraine, in accordance with international practice, where already successfully tested the relevant legislative technology of solving them, not only by the approval of amendments to existing laws or the development of new, and by codification – the development and adoption Of Code of Ukraine. However, still conceptual appropriateness of adopting an information code in Ukraine has not found adequate technological support, that negatively affects the development of information-communicative System State. Today in Ukraine is a strategic document that at the national level to govern the main priorities, directions, principles, principles and ways of realization of the State policy on implementing its information and communication functions. Moreover the communicative component state is not clearly separated from the information, and therefore does not have the proper conceptual, technological and functional software, also destablzacjno affects the livelihoods of its public sector.
Data from Deletion of Calcineurin Promotes a Protumorigenic Fibroblast Phenotype

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<div>Abstract<p>Fibroblast activation is a crucial step in tumor growth and metastatic progression. Activated fibroblasts remodel the extracellular matrix (ECM) in primary tumor and metastatic microenvironments, exerting both pro- and antitumorigenic effects. However, the intrinsic mechanisms that regulate the activation of fibroblasts are not well-defined. The signaling axis comprising the calcium-activated Ser/Thr phosphatase calcineurin (CN), and its downstream target nuclear factor of activated T cells, has been implicated in endothelial (EC) and immune cell activation, but its role in fibroblasts is not known. Here, we demonstrate that deletion of CN in fibroblasts <i>in vitro</i> altered fibroblast morphology and function consistent with an activated phenotype relative to wild-type fibroblasts. CN-null fibroblasts had a greater migratory capacity, increased collagen secretion and remodeling, and promoted more robust EC activation <i>in vitro</i>. ECM generated by CN-null fibroblasts contained more collagen with greater alignment of fibrillar collagen compared with wild-type fibroblast-derived matrix. These differences in matrix composition and organization imposed distinct changes in morphology and cytoskeletal architecture of both fibroblasts and tumor cells. Consistent with this <i>in vitro</i> phenotype, mice with stromal CN deletion had a greater incidence and larger lung metastases. Our data suggest that CN signaling contributes to the maintenance of fibroblast homeostasis and that loss of CN is sufficient to promote fibroblast activation.</p>Significance:<p>Calcineurin signaling is a key pathway underlying fibroblast homeostasis that could be targeted to potentially prevent fibroblast activation in distant metastatic sites.</p></div>
Structural Characteristics and Large Non-Linear Optical Responses of New Alkaline Earth-Based Alkalides

Field: Chemistry (Physical Sciences)

A series of M2+(H5Aza222)–M'– (M = Be, Mg, Ca; M' = Li, Na, K) alkalides that contain alkaline earth metal cations complexed by the H5Aza222– cage have been investigated using the CAM-B3LYP method. These alkaline earth-based alkalides not only present unusual structural features but also exhibit extraordinarily large static first hyperpolarizabilities (ß0) up to 1.98 × 105 au. By comparing the ß0 values among alkalides with various complexants, the Aza222 cage is found to be preferable to the previously investigated calix[4]pyrrole and n6adamanzane (n = 2, 3) complexants in enhancing the first hyperpolarizabilities of alkalides. In addition, the relationships between the ß0 values of M2+(H5Aza222)–M'– and the atomic number of the M'– anion, the atomic number of the M2+ cation, and the M–M' distance are explored.
Extensional rheology of entangled granular materials

Field: Materials Science (Physical Sciences)

We study the response of collections of U-shaped granular particles to extensional loading. Cylindrical samples elongate in bursts, as existing particle entanglements yield and new ones are created. The probability of failure scales with applied force F as . Longer samples are weaker than shorter ones, with the mean yield force scaling with instantaneous length L as . Both results can be explained with a Weibullian weakest-link theory that posits that samples are comprised of smaller sub-units. We find the yield probability of a sub-unit to scales with applied force as Fm and, from experiments, determine . This is then used to capture the complete two-dimensional failure probability distribution .
Spectroscopic and electrochemical study of interactions between DNA and different salts of 1,4-dihydropyridine AV-153

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

1,4-dihydropyridines (1,4-DHP) possess important biochemical and pharmacological properties, including antimutagenic and DNA-binding activity. The latter activity was first described for water-soluble 1,4-DHP with carboxylic group in position 4, the sodium salt of the 1,4-DHP derivative AV-153 among others. Some data show the modification of physicochemical properties and biological activities of organic compounds by metal ions that form the salts. We demonstrated the different affinity to DNA and DNA-protecting capacity of AV-153 salts, depending on the salt-forming ion (Na, K, Li, Rb, Ca, Mg). This study aimed to use different approaches to collate data on the DNA-binding mode of AV-153-Na and five other AV-153 salts. All the AV-153 salts in this study quenched the ethidium bromide and DNA complex fluorescence, which points to an intercalation binding mode. For some of them, the intercalation binding was confirmed using cyclic voltammetry and circular dichroism spectroscopy. It was shown that in vitro all AV-153 salts can interact with four DNA bases. The FTIR spectroscopy data showed the interaction of AV-153 salts with both DNA bases and phosphate groups. A preference for base interaction was observed as the AV-153 salts interacted mostly with G and C bases. However, the highest differences were detected in the spectral region assigned to phosphate groups, which might indicate either conformational changes of DNA molecule (B form to A or H form) or partial denaturation of the molecule. According to the UV/VIS spectroscopy data, the salts also interact with the human telomere repeat, both in guanine quadruplex (G4) and single-stranded form; Na and K salts manifested higher affinity to G4, Li and Rb –to single-stranded DNA.
Biological effects of agricultural bio-materials on some blood and tissue factors in Balb/c mice

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Pseudomonas infections are an important cause of morbidity and mortality and saprophytic fungi are now increasingly being recognized as serious pathogens in immunocompromised patients.To investigate the effect of using bio-materials on mammalian tissues,two experiments were designed;the first one was feeding of Balb/c mice with irrigated lettuce with bio-fungicide (mutant and wild)and bio-fertilizers prepared with Pseudomonas (p) fluorescens, p. putida, p. aeruginosa, and the second was the usage of drinking water containing (Trichoderma (T) spores (mutant and wild) or P.fluorescens, P.putida, P.aeruginosa suspensions). Then, blood factors and inflammation of tissues (liver, kidney, spleen and large intestine) in all mice were analyzed after two months. Blood samples were taken from the mice to examine some of the hematological (RBC, MCV, MCH, MCHC) (data not shown) and biochemical (AST, ALT, ALP) factors, and also observed under a microscope. The study of tumor marker carcinoembryonic antigen (CEA) in all treatments showed that the strains in these bio-fertilizers did not stimulate carcinogenic indices.The results from the other blood factors were normal for all strains (data not shown).Only P.putida showed no adverse effect on the increase in alkaline phosphatase (ALP).The results also showed that the effect of bio-fungicide on mammalian tissues (spleen and large intestine) was normal. But a small number of mild liver necrosis was seen in the treatment groups with wild Trichoderma, and moderate necrosis in the the liver tissue after treatment with mutant Trichoderma isolates.More investigation should be made to determine the impact of these biotic factors on the mammalian tissues before commercialization.
Nalar Hukum Islam Terhadap Konsep Perpajakan Modern

Field: Arts and Humanities (Social Sciences)

<p>Tax discourse in the context of the modern state will always be attractive along with the shifting orientation, purpose and function of the state that not only maintains public order and public security -nachwakersstaat - but the state must be able to present a prosperous condition -verzogingstaat or welvarsstaat- in the midst of its people. This gives consequences to the state in taking responsibility for the welfare of its people. Tax is one of the instruments used by the state as capital to carry out the welfare mission levied from the people, on the people's mandate as well as taxes are then distributed. The construction of thought in this peaper is based on the benefit aspect of the function and role of the tax. The value of tax benefits as keywords in the utilization of taxes that synergize with the basic values maslahah mursalah or maqashid shari'ah (Islamic law)</p>
Altered DNA repair related proteins in Parkinson’s disease model VMAT2 Lo mice

Field: Neuroscience (Life Sciences)

Abstract DNA damage and repair processes play an important role in the pathogenesis of age-related neurodegenerative diseases such as Parkinson’s Disease (PD), as DNA repair pathways delay cell senescence and aging by maintaining genomic integrity. In the present study, the expression of DNA repair-related enzymes and proteins were examined in the brain of VMAT2 Lo mice, a PD animal model. The results demonstrated that in the frontal cortex (FC) and locus coeruleus (LC) of VMAT2 Lo mice at 2, 6, and 15 months of age, OGG1 protein levels were significantly increased. However, OGG1 protein levels in the hippocampus, substantia nigra (SN) and LC of these model mice at 18 and 23 months of age exhibited a marked reduction. This reduction of OGG1 proteins in the hippocampus and SN was accompanied by the relatively similar diminishment of their mRNAs. Furthermore, immunochemical and immunofluorescence staining demonstrated that in most measured brain regions, the immunoreactivities of PARP1, ERCC1, XRCC1 and PCNA, four enzymes and protein related to DNA repair processes, were considerably reduced in VMAT2 Lo mice at 18 and 23 months of age. These analysis results reveal the DNA oxidative damage triggers the activation of DNA repair process in this PD model, and provides important insights for the involvement of DNA repair processes in the PD pathogenesis.
The morphology of the preimaginal stages of Cleopomiarus micros (Germar, 1821) (Curculionidae, Coleoptera) and notes on its biology

Field: Agricultural and Biological Sciences (Life Sciences)

As yet little is known of the bionomics of weevils of the genus Cleopomiarus Pierce, 1919; current knowledge is limited to data on the morphology and biology of the preimaginal stages of certain species. This paper includes original information on the life cycle of Cleopomiarusmicros (Germar, 1821). It presents the morphology of the egg, last larva (L 3 ) and pupa. Data on the host plant ( Jasionemontana L.) and breeding plant ( Campanulapatula L.) and on the oviposition and phenology of the species are updated. The anatomy of the third-stage larva of C.micros shares certain traits with other species of the tribe Mecinini Gistel, 1848. Comparison of the morphology of preimaginal stages of C.micros with those previously described for other species of the genera Cleopomiarus and Miarus Schönherr, 1826 – previously considered the same genus – reveals species differences in larval body length, colour of the body and epicranium, and chaetotaxy of head and body.
Homogeneity analysis of localities in the city of Rio de Janeiro in relation to rental prices: a case study

Field: Decision Sciences (Social Sciences)

This article aims to present the application of Homogeneity analysis as an alternative to the analysis of qualitative data. Homogeneity analysis is a multivariate technique that has two basic purposes: dimensionality reduction and structural analysis. The work examined actual values of average rents for residential sites in 24 districts of the city of Rio de Janeiro in December 2010 for living room and bedroom, living room and two bedrooms and living room and three bedrooms. The study aimed at the grouping of localities due to similarity in their average rents. As the result of the analysis, we identified 3 homogeneous groups, coexisting in the same space. Profile 1 is formed by neighborhoods with rents in lower ranges. Most of the neighborhoods in this profile are on the westside and northside. Profile 2 is formedby neighborhoods with rents in the intermediate ranges. They include the south zone and Barra. Profile 3 is formedby neighborhoods with rents in higher ranges. They include only neighborhoods in the South side. These results are important to highlight the importance of Homogeneity analysis as to decisions by real estate administrators.
Coregulation of Voltage-Dependent Kinetics of Na+and K+Currents in Electric Organ

Field: Neuroscience (Life Sciences)

The electric organ cells of Sternopygus generate action potentials whose durations vary over a fourfold range. This variation in action potential duration is the basis for individual variation in a communication signal. Thus, action potential duration must be precisely regulated in these cells. We had observed previously that the inactivation kinetics of the electrocyte Na + current show systematic individual variation. In this study, using a two-electrode voltage clamp, we found that the voltage-dependent activation and deactivation kinetics of the delayed rectifying K + current in these cells covary in a graded and predictable manner across fish. Furthermore, when Na + and K + currents were recorded in the same cell, their voltage-dependent kinetics were highly correlated. This finding illustrates an unprecedented degree of coregulation of voltage-dependent properties in two molecularly distinct ionic channels. Such a coregulation of ionic channels is uniquely observable in a cell specialized to generate individual differences in electrical activity and in which the results of biophysical control mechanisms are evident in behaving animals. We propose that the precise coregulation of the voltage-dependent kinetics of multiple ionic currents may be a general mechanism for regulation of membrane excitability.