jimnoneill/paper-to-field-training huggingface dataset:
New Modified Deoxythymine with Dibranched Tetraethylene Glycol Stabilizes G-Quadruplex Structures

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Methods for stabilizing G-quadruplex formation is a promising therapeutic approach for cancer treatment and other biomedical applications because stable G-quadruplexes efficiently inhibit biological reactions. Oligo and polyethylene glycols are promising biocompatible compounds, and we have shown that linear oligoethylene glycols can stabilize G-quadruplexes. Here, we developed a new modified deoxythymine with dibranched or tribranched tetraethylene glycol (TEG) and incorporated these TEG-modified deoxythymines into a loop region that forms an antiparallel G-quadruplex. We analyzed the stability of the modified G-quadruplexes, and the results showed that the tribranched TEG destabilized G-quadruplexes through entropic contributions, likely through steric hindrance. Interestingly, the dibranched TEG modification increased G-quadruplex stability relative to the unmodified DNA structures due to favorable enthalpic contributions. Molecular dynamics calculations suggested that dibranched TEG interacts with the G-quadruplex through hydrogen bonding and CH-π interactions. Moreover, these branched TEG-modified deoxythymine protected the DNA oligonucleotides from degradation by various nucleases in human serum. By taking advantage of the unique interactions between DNA and branched TEG, advanced DNA materials can be developed that affect the regulation of DNA structure.
Factors affecting the turnover intention of bank employees at the West Java Regional XBank Indonesia community

Field: Business, Management and Accounting (Social Sciences)

This study determines the factors that influence bank employee turnover intentions and explores new phenomena in employee turnover intentions in the banking sector which are influenced by spiritual aspects. The object examined in this study is turnover intention. A quantitative-descriptive method is employed in this work. Primary data collection was performed using a questionnaire. The population of respondents consists of 66 employees who joined the Xbank community. Multiple linear regression analysis was performed on the data. Results indicate that organisational and individual factors simultaneously affect the turnover intention of bank employees who are members of the West Java Regional Xbank Indonesia Community.
ABBREVIATIONS

Field: Arts and Humanities (Social Sciences)

Abstract Reading a paragraph of Latin without attention to the word order entails losing access to a whole dimension of meaning, or at least using inferential procedures to guess at what is actually overtly encoded in the syntax. This book introduces the linguistic concepts, formalism, and analytical techniques necessary for the study of Latin word order. It then presents and analyzes a representative selection of data in sufficient detail to foster both an intuitive grasp of the often rather subtle principles controlling Latin word order and a theoretically grounded understanding of the system that underlies it. Combining the rich empirical documentation of traditional philological approaches with the deeper theoretical insight of modern linguistics, this book aims to reduce the intricate surface patterns of Latin word order to a simple and general cross-categorical system of syntactic structure which translates more or less directly into constituents of pragmatic and semantic meaning.
A Study on the Effect of Cruise Tourists' Expectation and Performance on Satisfaction and Repurchase of Cruise Products.

Field: Business, Management and Accounting (Social Sciences)

This study was conducted to identify the expectations and performance of cruise tourists who have experience in cruise tour and to investigate how each result affects the satisfaction of cruise tourists and how this resulted satisfaction eventually influence them in repurchasing of cruse products. The survey was conducted for a week from Jan 21 to 27, 2019 on tourists who have experiences in cruise tour. Total 148 surveys were collected and used for final analysis. The coded data were analyzed using SPSS 22.0 for Windows. The study have shown that expectation of experience affect all performance factors of deviance, interest, sociability, and experientiality. In addition, in performance, all factors of deviance, interest, sociability, and experientiality affected satisfaction, while only deviance had a significant effect on satisfaction.
Influence of Parental Expectancies and Responsiveness on Achievement Motivation of Minimally Brain-Injured and Normal Children

Field: Psychology (Social Sciences)

16 families with minimally brain-injured children and 16 families with normal children were matched on a number of characteristics. The two groups differed in regard to mothers' expectancies for achievement, fathers' rewards for success and punishment for failure, and children's need for achievement. Moreover, parents had a significant influence on their children's achievement motivation but patterns of relationships were not the same for the two groups.
Assessment of Knowledge and Perception Regarding ChatGPT Usage in Dental Students from North India

Field: Health Professions (Health Sciences)

Objectives Chat Generative Pre-trained Transformer (ChatGPT) has numerous applications and has recently been tested in medical and dental sciences. The study was designed to assess knowledge and perception related to ChatGPT among dental students. Material and Methods A closed-ended questionnaire consisting of a binary scale (yes and no) was used to evaluate knowledge and perception related to ChatGPT. Descriptive statistics were computed, and inferential statistics were computed using the Chi-square test to gauge the association of responses with gender. Results Around 82.2% of students possessed knowledge of ChatGPT, and 89.3% of students expressed willingness to be trained for the use of ChatGPT. Nonetheless, 52% did not consider that ChatGPT misleads the dental community. Two-thirds subjects thought ChatGPT was functional in identifying periapical lesions, dental caries, and assisting in the prevention of dental diseases. Around 83.6% thought that ChatGPT would assist in tele-dentistry, and two-thirds envisioned its use in implant dentistry. The subjects agreed that ChatGPT was able to simulate human intellect, and 67.6% were of the opinion that it was ethically applicable. Conclusion Therefore, students had sufficient knowledge regarding ChatGPT and expressed a desire to integrate ChatGPT into the dental profession.
Cell-to-module Analysis beyond Standard Test Conditions

Field: Energy (Physical Sciences)

Cell-to-module analysis has been an invaluable tool in photovoltaic module design and technology evaluation in the past. Analysis and prediction of module power and efficiency at standard test conditions, and comparing losses and gains between module setups provides a means of virtual prototyping and enables digital module optimization. This toolset has been expanded beyond standard test conditions, to include realistic illumination and ambient conditions. Models are developed to account for these parameters. Additional loss and gain factors are introduced to account for performance changes on the cell level and to attribute changes to different operation parameters.
Kazimierz Stabrowski’s esoteric dimensions theosophy, art, and the vision of femininity

Field: Arts and Humanities (Social Sciences)

The aim of this paper is to present the Theosophical inspirations that shaped the idea of femininity in the works of the painter Kazimierz Stabrowski (1869-1929). The Theosophical movement began to develop in Poland at the turn of the 20th century. Kazimierz Stabrowski was one of the most influential figures in Theosophical circles, a first leader of the first Theosophical association officially sanctioned by the state in Polish lands, and later a member of the Anthroposophical movement. His circle also impacted on the development of esoteric ideas in a wider context in Europe, as one of Stabrowski’s students who became interested in Theosophy during his studies was a prominent Lithuanian artist - Mikalojus Konstantinas Čiurlionis. As an artist Stabrowski belonged to the movement known as Young Poland (Młoda Polska), shaped by Art Nouveau and modernist symbolism. Nature was for him the purest manifestation of femininity. His visions of women are personifications of beauty; they are full of inner light, power, and possessors of uncountable mysteries. Above all Stabrowski wanted to develop and emphasize the spiritual element of his works of art. He developed his own, unique style that can be recognized in his portraits, visionary-symbolic compositions and landscapes. In those works, the fascination with occultism, Theosophy and Anthroposophy can be clearly seen.
Study on Peroxidase and Esterase Isoenzymes and the Ultrastructure of the Space Induced Mutant Leaves of Sainfoin(Onobrychis viciaefolia Scop.)

Field: Agricultural and Biological Sciences (Life Sciences)

Some of the sainfoin (Onobrychis viciaefolia Scop.)seeds returning from a trip to space with the airship ShenZhou NO.4 sprouted creepy mutants. An analysis of the peroxidase and esterase isoenzymes and the ultrastructure of the leaves of the mutants, those of the space-travelled but stand-up sainfoin plants, and those of the control, was carried out. It shows that all the three examined types have similar band number of peroxidase isoenzymes. The mutant and the control give the same band number of esterase isoenzymes, while the stand-up sainfoin possesses more band number of esterase isoenzymes than the other two. It also shows that, compared to the ultrastructure of the control, that of the two types of space induced sainfoin plants, more particularly the creepy mutant, exhibit the following abnormalities: irregularly thickening of the cell wall, thinning of the cytoplasm, bigger vacuoles, smaller chloroplasts of irregular shapes, smaller but more numerous amyloid granules contained in chloroplasts, and shorter diameter of stroma thylakoid membranes but more membrane layers.
The challenges of a wider and deeper Europe

Field: Economics, Econometrics and Finance (Social Sciences)

Europe is changing all the time. It is getting deeper and wider in a process that often looks confusing, but the trend is unmistakable. At this stage of our history, we are facing two challenges: widening by including most of the rest of the continent, and deepening to both perfect the existing economic arrangements and reap more benefits in largely untapped non-economic areas. The need for further deepening is highly controversial. The benefits come in the form of enhanced effectiveness. The costs result from information asymmetries and heterogeneity. Much of the integration process so far has concerned economic public goods, where desirable centralization is now almost complete. Some loose ends still need to be dealt with, but most deepening challenges concern non-economic issues. In particular, a cool-blooded analysis suggests that internal and external security and foreign affairs are areas where the benefits of centralization are high. The costs too, are high, largely because preferences differ from one country to another, this is sometimes called nationalism, even though public opinions seem to support common defense and foreign policies. Is widening making deepening harder? For this to be the case we would need to see an increase in the costs of deepening over and beyond the benefits. There is little evidence of that. It is often believed that the real problem is that decision-making becomes more difficult with more members. This is true with the current institutions and procedures, but it does not have to be the case. This is precisely the challenge that was faced by the Convention. Its draft treaty makes a number of important proposals that stand to improve decision making and to preserve the ability for a wider Europe to become deeper as well. On the other side, progress is difficult because of the representation problem, the need for minority views to be taken on board when they are strongly held. This aspect often takes the form of the long-simmering conflict between large and small countries. But many issues often cut across national lines. What Europe misses is a Pan-European political representation of these views. This is an area where the Convention has been silent. The Challenges of a Wider and Deeper Europe Charles Wyplosz Graduate Institute of International Studies and CEPR
Marinas in Sydney Harbour - an Environmental Curse or Blessing?

Field: Environmental Science (Physical Sciences)

The boat storage/mooring situation in Sydney Harbour is reviewed and the appropriateness of various boat storage modes are discussed. The environmental impacts of marinas in an urbanised estuary such as Sydney Harbour are listed, concluding that a well-founded marina proposal is of social and environmental benefit to the community. The reason for the lack of adequate berthing facilities is discussed, with particular reference to the approvals procedure. The appropriateness of declaring marinas 'designated development' is explored, and alternatives suggested for ways to simplify the approvals process.
Investigation and Analysis of Automatic Injection Drug Dispensing System in Inpatient Dispensary

Field: Health Professions (Health Sciences)

OBJECTIVE:To optimize drug for injection dispensing model in order to supply reference for popularity of automatic injection drug dispensing system(AIDDS) in inpatient dispensary.METHODS:Two kinds of drug dispensing model were adopted in five departments.In 10 working days before and after application of AIDDS,the time of drug dispensing flow needed was recorded.The time of every drug dispensing step needed for single patient was recorded and analyzed to evaluate the benefit of system.RESULTS:After application of AIDDS,the drug dispensing time for single patient reduced from 1.5～2.1 min to 0.45～0.80 min.The drug dispensing efficiency was improved significantly,the extent of which was in positive correlation to amount of patient demanding drug dispensing.CONCLUSION:The application of AIDDS speedups drug for injection dispensing,shortens dispensing time and saves human resource.
Temporal, spatial and hormonal regulation of the S‐adenosylmethionine synthetase gene in petunia

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Gibberellic acid (GA 3 ) promotes corolla elongation and pigmentation in petunia flowers. We have previously shown that G.A 3 induces pigmentation by activating specific genes of the anthocyanin biosynthetic pathway. The aim of the present work was to examine whether GA 3 induces also the expression of genes from other metabolic pathways in petunia corollas that may be associated with growth. Recently we reported the cloning of the petunia sam gene coding for S ‐adenosylmethionine synthetase (SAM‐S). In the present work we show that sam expression is induced by GA 3 in both corollas and stems. The expression of the gene was correlated with corolla elongation. GA 3 and the cylokinin, N ‐6‐benzyladenine (BA) promoted corolla growth and sam expression, whereas abscisic acid (ABA) inhibited corolla elongation and repressed sam mRNA accumulation. An analysis of sam expression in stems indicated a high level in young, elongating internodes and a very low level in the mature, non‐elongating stem zone. The results of the present study show that the effect of GA 3 on gene expression in the corolla of petunia, is not restricted to the anthocyanin biosynthetic pathway, they also suggest a possible role for sam in GA 3 ‐induced corolla and stem elongation.
On the central effects of a new partial benzodiazepine agonist Ro 16-6028 in man: pharmaco-EEG and psychometric studies.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

In a double-blind placebo-controlled study, the encephalotropic and psychotropic properties of a new partial benzodiazepine agonist Ro 16-6028 were investigated as compared to a pure agonist diazepam utilizing quantitative EEG and psychometric analysis as well as clinical observations. Ten normal volunteers received randomized (latin square design) and at weekly intervals, single oral doses of placebo, 0.05 mg, 0.1 mg and 0.2 mg Ro 16-6028 and 10 mg diazepam as reference substance. EEG-recordings, psychometric tests and evaluation of blood pressure, pulse and side effects were carried out at 0, 1, 2, 3, 4 and 6 h. Computer-assisted spectral analysis of the EEG demonstrated after 10 mg diazepam, a typical "anxiolytic" pharmaco-EEG profile characterized by an increase of beta activity, decrease of alpha activity and acceleration of the centroid total activity. Ro 16-6028 induced in the vigilance-controlled recordings a similar profile thereby exhibiting tranquilizing properties too. However, in the resting condition we observed also an increase of delta/theta activity along with a decrease of alpha activity while the beta augmentation was observed mostly in the fast frequency bands and not so much in the middle fast frequency bands as is the case with the known full agonists. The latter findings were somewhat reminiscent of the pharmaco-EEG profiles seen often in certain neuroleptics. Our data indicate a selective sedation after the novel partial agonist. Dose/treatment-efficacy calculations demonstrated 10 mg diazepam as the most CNS-effective drug followed closely by 0.2 mg Ro 16-6028, 0.1 mg and 0.05 mg, while placebo induced the least changes. Only 0.2 mg Ro 16-6028 and the reference compound differed from placebo at all times. Time-efficacy calculations showed a peak effect of the novel partial agonist around the 3rd h and that of diazepam in the 1st h. Psychometric tests demonstrated similar findings. After 0.2 mg Ro 16-6028 a decrease of attention, numerical memory, psychomotor activity, wakefulness and CFF was observed, while mood improved at later time periods outlasting the sedation. After 10 mg diazepam 10 out of 13 psychometric and psychophysiological variables showed significant findings previously described as typical for anxiolytic sedatives in normals. On the whole, the partial agonist induced less sedation than the full agonist, which is reflected in its superiority in regard to noopsychic and thymopsychic functions. Evaluation of pulse and blood pressure showed no clinically relevant findings. The new partial agonist was well tolerated.
Pd(II), Pt(II), Rh(III), Ir(III) and Ru(III) Complexes of n-Pentyl and n-Hexyl Ketone Thiosemicarbazones

Field: Chemistry (Physical Sciences)

Abstract Pd(II), Pt(II), Rh(III), Ir(III) and Ru(III) complexes of thiosemicarbazones of methyl-n-hexylketone and methyl-n-pentylketone have been prepared and characterised by elemental analyses, magnetic moments, i.r. and electronic spectral studies. These complexes were found to have the compositions M(ligand)2Cl2 (M = Pd or Pt) and M(ligand)3Cl3 (M = Rh, Ir and Ru). All the complexes are diamagnetic except Ru(ligand) 3C13. The Pd(II) and Pt(II) complexes are of square planar geometry. Rh(III), Ru(III) and Ir(III) complexes are six-coordinate octahedral. Various ligand field parameters have been calculated and discussed.
Skilled reaching deficits in unilateral dopamine-depleted rats: impairments in movement and posture and compensatory adjustments

Field: Neuroscience (Life Sciences)

Rats receiving unilateral dopamine (DA) depletions have bilateral deficits in using the forelimbs for skilled reaching. These impairments were investigated using end-point, video, and kinematic measures. Control rats and groups of rats with > 98% unilateral depletions (confirmed by tissue, apomorphine, and amphetamine assay), produced by 6-hydroxydopamine (6-OHDA) injected into the nigrostriatal bundle, were tested for 100 d on two reaching tasks. One depleted group used the contralateral-to-lesion (bad), and the other the ipsilateral-to-lesion (good), limb. Rats using their bad limb made few successful reaches and had dysfunctions in aiming, pronating, and supinating, and in using the digits to grasp and release food. Rats using the good limb were initially impaired, but improved, and could make these movements. Neither depleted group was able to use their bad limbs to assist actively the postural changes required for reaching. Thus, they did not use the diagonal supporting pattern (the nonreaching forelimb and diagonal hind limb) from which control rats initiated reaching. The group using their bad limb initiated reaching from a base of support distributed on the ipsilateral-to-lesion limbs, while the group using their good limb initiated reaching from a base of support centered on the ipsilateral rear limb. The impairments in making voluntary movements and postural adjustments with the bad limbs and the behavioral changes introduced by the compensatory dependency on good limbs account for the bilateral deficits in skilled movements. The results show that DA is required for skilled movements and postural adjustments and demonstrate that behavioral compensation can contribute to recovery.
Notes on the Churchyards of Currie, Kirknewton, and the Calders

Field: Arts and Humanities (Social Sciences)

The earliest record of the ancient church of Killeith dates from 1296.In that year, William, Archdeacon of Lothian, and parson of the church of Keldeleth, swore fealty to Edward I. ; and, from a tascatio of that monarch's reign, we learn that this church, which was dedicated to St Kentigern, was rated at 50 marks, and pertained to the Priory of Coldingham.Till the Reformation, Killeith was regarded as the appropriate benefice of the Archdeaconry of Lothian, changing its status with its name, when, in 1584, James VI. granted to the newly founded college of Edinburgh the vicarage of Currie, with all its endowments.Through this transference the Town Council of Edinburgh became the patrons of the parish, which during the sixteenth and seventeenth centuries was variously styled Killeith and Currie.Error has arisen from the assumption that the ancient Killeith-now Kinleith-and the later Currie were distinct and separate places.There is not the slightest foundation for that opinion, and within the churchyard of Currie there remains its clearest refutation.Here are the picturesque ruins of an ecclesiastical building, interesting historically and architecturally, and venerable enough to determine the site of the church which, though it changed its name, can only most unreasonably be charged with changing its local habitation.This mediaeval fragment undoubtedly formed the choir of the ancient church of Killeith.For many generations it has been used as a place of burial, and its history shows that at a dark period it was the reputed haunt of witches, serving at another time as the school of Currie parish.Its vaulted roof was a source of trouble to the heritors, who were repeatedly charged for its repair.In 1778, they appointed "the upper arch of the Quire to be taken down by day's wages, and the lower arch to stand as it is."Further, that " the lower arch of the Quire be covered by the flag stones, VOL.XL.