jimnoneill/paper-to-field-training huggingface dataset:
The Impact of Chronic Medical Conditions on Mortality in Acute Respiratory Distress Syndrome

Field: Medicine (Health Sciences)

Purpose To examine the impact of chronic comorbidities on mortality in Acute Respiratory Distress Syndrome (ARDS). Materials and Methods Retrospective cohort study of adults with ARDS (ICD-10-CM code J80) from the National Inpatient Sample between January, 2016 and December, 2018. For the primary outcome of mortality, we conducted weighted logistic regression adjusting for factors identified on univariate analysis as potentially significant or differing between the two groups at baseline. We used negative binomial regression adjusting for the same comorbidities to identify risk factors for longer length of stay (LOS) among ARDS survivors. Results After exclusions, 1046 records were analyzed (3355 ARDS survivors and 1875 non-survivors.) The comorbidities examined included hypertension, diabetes mellitus, obesity, hypothyroidism, alcohol and drug use, chronic kidney disease (CKD), cardiovascular disease, chronic liver disease, chronic pulmonary disease and malignancy. In multivariate analysis, we found that malignancy (OR 2.26, 95% CI 1.84-2.78, p < 0.001), cardiovascular disease (OR 1.54, 95% CI 1.23-1.92, p < 0.001), and CKD (OR 1.75, 95% CI 1.22-2.50, p = 0.002) increased the risk of death. In interaction analyses, cardiovascular disease combined with either malignancy or CKD conferred higher odds of death compared to either risk factor alone. Conclusions The comorbidity of malignancy confers the most reliable risk of poor outcomes in ARDS with higher odds of hospital death and a simultaneous association with longer hospital LOS among survivors.
Magnetic Properties of Superconducting Vanadium

Field: Physics and Astronomy (Physical Sciences)

Isothermal magnetization data were obtained for an annealed single crystal of vanadium (resistivity ratio $\frac{{\ensuremath{\rho}}_{273\mathrm{K}}}{{\ensuremath{\rho}}_{4\mathrm{K}}}=450$) in prolate spheroidal form in the temperature interval from $T=1.4$ K to ${T}_{c}(=5.43 \mathrm{K})$, which was measured to be 5.43 \ifmmode\pm\else\textpm\fi{} 0.02 K. To minimize surface pinning and increase the reversibility of the bulk magnetization, the sample surface was subjected to an oxidation treatment. Values of the thermodynamic critical field ${H}_{c}(t)$ determined from the data are in good accord with the earlier results of Radebaugh and Keesom, and the Ginzburg-Landau parameter was deduced from the measurements to be $\ensuremath{\kappa}(1)=0.85\ifmmode\pm\else\textpm\fi{}0.02$. In the limit of infinite electronic mean free path it is found that ${\ensuremath{\kappa}}_{0}=0.82$ for this sample. The temperature variations of ${\ensuremath{\kappa}}_{1}(t)$, ${\ensuremath{\kappa}}_{2}(t)$, and the parameter ${h}^{*}(t)=\frac{{H}_{c2}(t)}{{(\ensuremath{-}\frac{d{H}_{c2}}{\mathrm{dt}})}_{t=1}}$ are discussed and compared with previous work. The results tend to confirm the importance of Fermi-surface anisotropy effects in type-II superconductors in the clean limit.
Essential Oils in Livestock: From Health to Food Quality

Field: Veterinary (Health Sciences)

Using plant essential oils (EOs) contributes to the growing number of natural plants’ applications in livestock. Scientific data supporting the efficacy of EOs as anti-inflammatory, antibacterial and antioxidant molecules accumulates over time; however, the cumulative evidence is not always sufficient. EOs antioxidant properties have been investigated mainly from human perspectives. Still, so far, our review is the first to combine the beneficial supporting properties of EOs in a One Health approach and as an animal product quality enhancer, opening new possibilities for their utilization in the livestock and nutrition sectors. We aim to compile the currently available data on the main anti-inflammatory effects of EOs, whether encapsulated or not, with a focus on mammary gland inflammation. We will also review the EOs’ antioxidant activities when given in the diet or as a food preservative to counteract oxidative stress. We emphasize EOs’ in vitro and in vivo ruminal microbiota and mechanisms of action to promote animal health and performance. Given the concept of DOHaD (Developmental Origin of Health and Diseases), supplementing animals with EOs in early life opens new perspectives in the nutrition sector. However, effective evaluation of the significant safety components is required before extending their use to livestock and veterinary medicine.
Energy-Resolved Collision-Induced Dissociation Cross Sections of 2:1 Bis-oxazoline Copper Complexes. Nonbonded Interactions and Nonlinear Effects

Field: Chemistry (Physical Sciences)

Absolute ligand binding energies are determined for the 2:1 complexes of bis-oxazoline ligands and Cu(I) in the gas phase by the fitting of energy-resolved collision-induced dissociation cross sections. The complexes were chosen for their occurrence in asymmetric catalysis for which the phenomenon of nonlinear effects is explained by differences in stability for homochiral and heterochiral complexes. Pseudo-enantiomeric ligands are used so that mass spectrometric measurements can be employed. The measurements find that the sterically similar, but electronically different, isopropyl versus phenyl substituents lead to a different stability ordering of the homo- versus heterochiral complexes, which then leads to the prediction of nonlinear effects in asymmetric catalysis by the complexes with isopropyl-substituted ligands. The origin of the difference in stability order is found in noncovalent interactions between the phenyl groups on the ligands, which are poorly described by DFT calculations.
Hydrogenation of ethylene over exploded palladium wire

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogenation of ethylene over exploded palladium wireCharles P. Nash and Ronald L. MusselmanCite this: J. Phys. Chem. 1970, 74, 10, 2166–2170Publication Date (Print):May 1, 1970Publication History Published online1 May 2002Published inissue 1 May 1970https://pubs.acs.org/doi/10.1021/j100909a021https://doi.org/10.1021/j100909a021research-articleACS PublicationsRequest reuse permissionsArticle Views43Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A META-ANALYSIS ON THE EFFECTIVENESS OF MALARIA COMMUNITY-BASED INTERVENTION

Field: Health Professions (Health Sciences)

Introduction: The community-based intervention was proven as one of the best approaches in combatting malaria. It is widely used to reduce malaria cases worldwide. A multisectoral approach must be made to ensure the success of the intervention. Therefore, this study is aimed is to determine the effectiveness of community-based intervention for malaria based on recent findings. Methods: A search strategy using Pub Med and Cochrane database platform investigating the effectiveness of malaria community-based intervention. There are selected terms and words predefined to obtain a comprehensive search strategy that included text fields within records and Medical Subject Headings (MeSH terms). Results: Eight articles were selected for this study. This review identified six communitybased interventions for malaria and four outcome measures. Most of the studies included a low risk of bias in each criterion except for random sequence and allocation of concealment. The meta-analysis found that the overall incidence difference of the included studies was significant (0.05 CI 0.02, 0.08), while the subgroup analysis of Permethrin LLIN the I2 was reduced to 75%. However, the overall usage percentage difference in health education and community mobilization to improve intervention usage was not significant (0.28 CI -0.02, 0.58). Conclusion: The community-based intervention approach is practical to fight malaria thus, to reduced mortality due to malaria. An integrated approach and engagement with multiagency will ensure outstanding achievement in fighting malaria.
Review of Research Trends regarding Vocabulary Intervention Using Keyword Network Analysis

Field: Health Professions (Health Sciences)

[목적] 본 연구는 키워드 네트워크 분석을 시행하여 어휘 중재 연구의 동향을 살펴보는 데 목적을 두었다. [방법] 어휘 중재 연구 동향을 알아보기 위해 학술연구정보서비스(RISS)와 한국학술지 인용색인(KCI)의 데이터베이스를 활용하여 어휘 중재 관련 문헌 78편을 최종적으로 수집하였다. 이후 텍스톰을 활용하여 키워드 정제를 시행한 후 키워드 빈도, 가중치(TF-IDF), 키워드의 공출현 빈도(N-gram)를 분석하였다. 1-mood 네트워크를 구축한 후 Ucinet의 Netdraw를 사용하여 핵심어 간의 중심성을 분석하고, 핵심어 연결 구조를 시각화하여 의미를 도출하였다. [결과] 첫째, 어휘 중재 관련 연구가 가장 활발히 이루어진 연도는 2011년과 2016년으로 밝혀졌다. 어휘 중재 관련 논문이 가장 많이 게재된 학술지는 언어치료 연구로 나타났다. 어휘 중재가 실시된 연령은 유아와 초등학교 저학년이 많은 것으로 나타났다. 둘째, 어휘 중재와 관련된 키워드 주요 172개 중 가장 높은 빈도를 나타낸 것은 어휘력 향상과 아동이었다. 어휘 중재 키워드의 가충치 (TF-IDF) 분석 결과 아동이 제일 높았으며, 다음으로 유아의 순으로 나타났다. N-gram(공출현)의 빈도는 어휘력 향상과 아동, 언어발달지체아동과 어휘력 향상이 동시에 높은 순으로 출현하는 것으로 분석되었다. 셋째, 네트워크 중심성을 분석한 결과 총 8개의 그룹군이 도출되었다. 각 그룹은 대상별로 관련 주제가 응집되어 나타났다. [결론] 어휘 중재 관련 연구의 동향을 객관적으로 분석한 본 연구는 향후 어휘 중재 관련 연구의 방향성을 모색하는데 필요한 기초자료로 활용할 수 있을 것이다.
Transport Collision Integrals for Gases Obeying 9–6 and 28–7 Potentials

Field: Physics and Astronomy (Physical Sciences)

Collision integrals for the 9–6 and 28–7 potentials are tabulated over a range of reduced temperatures kT/ε from 0.01 to 100. The results are compared with previous results for the 12–6 and ∞−6 potentials, including a simultaneous analysis of second virial coefficients for all four potentials. The viscosities are rather similar over wide temperature ranges, but the isotopic thermal-diffusion factors differ markedly.
X‐Band Radar Mapping of Morphological Changes at a Dynamic Coastal Inlet

Field: Earth and Planetary Sciences (Physical Sciences)

Abstract Remote sensing of the complex interactions between bathymetry, tidal flow, and waves in coastal inlets provides high‐resolution data sets that can be exploited to characterize the morphological variability of shallow ebb tidal deltas (ETD). Here we used observations from a mobile X‐band radar platform to determine optimal conditions during which radar‐derived shoal signatures best represent positions of underlying shoals. Significant increases in the spatial errors of radar shoal signatures were observed when offshore wave energy intensified. Consequently, the lowest spatial errors occurred when the radar shoal signatures were primarily a function of the tidal flow (i.e., low sea state). We used these findings to quantify shoal migration patterns at the New River Inlet, North Carolina. We found that the southwestern portion of the ETD had the largest morphological variability with typical shoreward migration rates of 2–3 m/day driven by incident wave energy. The migration rates and patterns estimated from X‐band observations were consistent with numerical modeling results and a previous video‐based New River remote sensing study. Our results confirm that X‐band radar can be used to quickly map shallow ETDs (e.g., 5 min of observations), allowing for rapid morphological assessments from shore or boat‐based platforms. The methods would prove particularly useful for initial assessment as well as continual monitoring of dynamic tidal inlets where large morphological responses can be rapidly assessed and used for geomorphological studies, and as decision aids for maritime or engineering operations.
Novel Interactions of Saccharomyces cerevisiae Type 1 Protein Phosphatase Identified by Single-Step Affinity Purification and Mass Spectrometry

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The catalytic subunit of Saccharomyces cerevisiae type 1 protein phosphatase (PP1(C)) is encoded by the essential gene GLC7 and is involved in regulating diverse cellular processes. To identify potential regulatory or targeting subunits of yeast PP1(C), we tagged Glc7p at its amino terminus with protein A and affinity-purified Glc7p protein complexes from yeast. The purified proteins were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and identified by peptide mass fingerprint analysis using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. To confirm the accuracy of our identifications, peptides from some of the proteins were also sequenced using high-performance liquid chromatography (HPLC) coupled to tandem mass spectrometry. Only four of the Glc7p-associated proteins that we identified (Mhp1p, Bni4p, Ref2p, and Sds22p) have previously been shown to interact with Glc7p, and multiple components of the CPF (cleavage and polyadenylation factor) complex involved in messenger RNA 3'-end processing were present as major components in the Glc7p-associated protein fraction. To confirm the interaction of Glc7p with this complex, we used the same approach to purify and characterize the components of the yeast CPF complex using protein A-tagged Pta1p. Six known components of the yeast (CPF) complex, together with Glc7p, were identified among the Pta1p-associated polypeptides using peptide mass fingerprint analysis. Thus Glc7p is a novel component of the CPF complex and may therefore be involved regulating mRNA 3'-end processing.
Geographies of Cubanidad: Place, Race, and Musical Performance in Contemporary Cuba

Field: Arts and Humanities (Social Sciences)

Book Review| January 01 2018 Geographies of Cubanidad: Place, Race, and Musical Performance in Contemporary Cuba Geographies of Cubanidad: Place, Race, and Musical Performance in Contemporary Cuba. Rebecca M. Bodenheimer. 2015. Jackson: University Press of Mississippi. xiv, 308 pp., black-and-white photographs, tables, map, musical examples, glossary, references. Printed case binding, $60.00; paper, $30.00. Raúl Fernández Raúl Fernández University of California at Irvine Search for other works by this author on: This Site Google Ethnomusicology (2018) 62 (1): 137–139. https://doi.org/10.5406/ethnomusicology.62.1.0137 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Raúl Fernández; Geographies of Cubanidad: Place, Race, and Musical Performance in Contemporary Cuba. Ethnomusicology 1 January 2018; 62 (1): 137–139. doi: https://doi.org/10.5406/ethnomusicology.62.1.0137 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveUniversity of Illinois PressEthnomusicology Search Advanced Search The text of this article is only available as a PDF. Copyright 2018 by the Board of Trustees of the University of Illinois2018 Article PDF first page preview Close Modal Issue Section: Book Reviews You do not currently have access to this content.
Abstract B068: Inhibition of GSK-3: A novel therapeutic approach for breast cancer treatment

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract NF-kappaB is known to regulate human breast cancer progression, metastasis and chemoresistance. Glycogen Synthase Kinase-3beta (GSK-3beta), a serine/threonine protein kinase, is an essential positive regulator of NF-kappaB transcriptional activity and thereby GSK-3beta may represent a potential therapeutic target in human breast cancer. Our objectives were to determine the expression pattern of GSK-3beta in human breast cancer, to assess the effect of GSK-3 inhibition on breast cancer cell proliferation, survival and chemoresistance, and to evaluate our lead GSK-3 inhibitors alone and in combination with chemotherapeutic drugs for the targeted therapy of breast cancer. Using nuclear/cytosolic fractionation, Western immunoblotting and immunohistochemical staining, we observed aberrant nuclear accumulation of GSK-3beta in five breast cancer cell lines and in 7 of 8 primary human breast carcinomas and corresponding lymph node metastases whereas no detectable expression of GSK-3beta was found in benign breast tissue. Pharmacological inhibition of GSK-3 led to a decrease in proliferation and survival of breast cancer cells. Our in vitro comparison studies demonstrated that our lead GSK-3 inhibitor 9-ING-41 was significantly (30 times) more effective than GSK-3 inhibitor LY2090314 (Eli Lilly), currently in mid-stage clinical trials, in terms of growth inhibition of breast cancer cells. Inhibition of GSK-3 resulted in decreased expression of the NF-kappaB target genes Bcl-2 and XIAP and induction of apoptosis. Moreover, our lead GSK-3 inhibitor 9-ING-41 and doxorubicin acted synergistically to suppress growth of breast cancer cells. Our preliminary in vivo experiments demonstrated that monotherapy with our lead GSK-3 inhibitor 9-ING-41 (20 mg/kg) for 48 hours inhibited proliferation (as shown by BrDU assay) and induced apoptosis (as shown by TUNEL assay) in MDA-MB-468 orthotopic xenograft tumors. Moreover, in vivo toxicology study demonstrated that intravenous injections of 9-ING-41 did not adversely affect mouse complete blood counts or cause overt pathological changes in mouse organs. Our results identify GSK-3beta as a new potential drug target in breast cancer and suggest that inhibition of GSK-3 is a novel therapeutic approach to overcome NF-kappaB-mediated chemoresistance in breast cancer. Citation Format: Andrey Ugolkov, Irina Gaisina, Dmitry Malin, Peter Kulesza, Alan Kozikowski, Vincent Cryns, Andrew Mazar. Inhibition of GSK-3: A novel therapeutic approach for breast cancer treatment. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications; Oct 3-6, 2013; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Res 2013;11(10 Suppl):Abstract nr B068.
From Local to Global—The Role of Geographical Isolation in Shaping Competition Law

Field: Social Sciences (Social Sciences)

Geographical isolation refers to the extent to which various boundaries that are concerned with politics, time, distance, and other such aspects isolate particular population centres from one another. This chapter asserts that geographical isolation, technological advances, and various improvements that both social and business organizations have undergone throughout the years, have brought about significant effects in shaping the approach that law adopts in dealing with competition. In doing this, the chapter identifies three major periods that are relevant in the history of competition law. The chapter first demonstrates, during the period of mercantilism, that law's approach was determined by geographical isolation. Secondly, it discusses how, in 19th-century America, the communications and transport revolution initiated the first modern system of competition law. Lastly, in the context of the current global era, the chapter examines the ‘e-revolution’, the transnational nature manifested in various business structures and aspects of trade liberalization.
Research in Special Education: Scientific Methods and Evidence-Based Practices

Field: Social Sciences (Social Sciences)

This article sets the context for the development of research quality indicators and guidelines for evidence of effective practices provided by different methodologies. The current conceptualization of scientific research in education and the complexity of conducting research in special education settings underlie the development of quality indicators. Programs of research in special education may be viewed as occurring in stages: moving from initial descriptive research, to experimental causal research, to finally research that examines the processes that might affect wide-scale adoption and use of a practice. At each stage, different research questions are relevant, and different research methodologies to address the research questions are needed.
Composition analysis of glass relics based on a clustering model

Field: Computer Science (Physical Sciences)

The analysis and identification of the chemical composition of ancient glass are of great significance for the evolution of history through time and space. The chemical content of ancient glass will change due to weathering, so a comprehensive evaluation model for the chemical content of the ancient glass is proposed in this paper. In this paper, the chi-square test is used to analyze the four classification variables, and it is found that there are significant differences between the ornamentation and colour, and the chemical composition content before weathering is predicted. Then the system clustering is used, and a subclass division model is proposed for the clustering results. Finally, the sensitivity analysis of the classification results is carried out, and different degrees of disturbance items are added respectively to obtain different model accuracy rates. The results show that the sensitivity of the model is better. The results show that the model can be used to analyze the composition of ancient glass relics and achieve good results.
Putting Cells in Motion: Advantages of Endogenous Boosting of BDNF Production

Field: Neuroscience (Life Sciences)

Motor exercise, such as sport or musical activities, helps with a plethora of diseases by modulating brain functions in neocortical and subcortical regions, resulting in behavioural changes related to mood regulation, well-being, memory, and even cognitive preservation in aging and neurodegenerative diseases. Although evidence is accumulating on the systemic neural mechanisms mediating these brain effects, the specific mechanisms by which exercise acts upon the cellular level are still under investigation. This is particularly the case for music training, a much less studied instance of motor exercise than sport. With regards to sport, consistent neurobiological research has focused on the brain-derived neurotrophic factor (BDNF), an essential player in the central nervous system. BDNF stimulates the growth and differentiation of neurons and synapses. It thrives in the hippocampus, the cortex, and the basal forebrain, which are the areas vital for memory, learning, and higher cognitive functions. Animal models and neurocognitive experiments on human athletes converge in demonstrating that physical exercise reliably boosts BDNF levels. In this review, we highlight comparable early findings obtained with animal models and elderly humans exposed to musical stimulation, showing how perceptual exposure to music might affect BDNF release, similar to what has been observed for sport. We subsequently propose a novel hypothesis that relates the neuroplastic changes in the human brains after musical training to genetically- and exercise-driven BDNF levels.
Two-Step Hydrothermal Synthesis of Submicrometric and Hierarchical Hollow SAPO-34 with Superior Catalytic Performance in Methanol to Olefin (MTO) Reaction

Field: Chemical Engineering (Physical Sciences)

A submicrometric and hierarchical hollow SAPO-34 molecular sieve was synthesized by an easy and low-cost two-step hydrothermal method. First, the crystallized mixture was obtained by direct drying after a first-step hydrothermal reaction. Then, the SAPO-34 product was obtained by adding the crystallized mixture to silicon-free gel and using cheap and common template agents. Compared to conventional SAPO-34, the submicrometric and hierarchical hollow SAPO-34 exhibits superior catalytic activity in the MTO reaction.