jimnoneill/paper-to-field-training huggingface dataset:
Assessment of quality of life by functional independence score in hemophilic patients: a single-center experience

Field: Medicine (Health Sciences)

Abstract Background Hemophilia is an inherited condition that is caused by the deficiency of clotting factors in the blood. The most common presentations of hemophilia are hemarthrosis and muscle hemorrhage. The severity of the bleeding episodes can vary from mild to severe resulting in pain and swelling of the joints and the muscles. Repeated musculoskeletal bleeding can result in hemophilic arthropathies with subsequent joint degeneration and deformity. Our study aims to clinically assess the quality of life in hemophilic patients in terms of disease severity and morbidity in our community using the Functional Independence Score for Hemophilia (FISH). Results Our cross-sectional study which involved 64 hemophilia patients revealed that the most affected joints were the weight-bearing large joints (knees, elbows, ankles) and this was associated with a lower FISH score. While the total FISH score showed a significant positive correlation with the factor activity level, the average FISH score was 21.11 ± 4.5, and the score was slightly lower in severe hemophilia compared to mild-moderate disease. Conclusion We concluded that there is a significant decline in the functional ability of hemophilia patients having disease affecting the knee and elbow joints. Moreover, squatting was significantly reduced in patients with severe hemophilia. The quality of patients’ life can be improved by early and regular physiotherapy and regular administration of the prophylactic factor.
1,5-Induction in Reactions between (5-Benzylthiopent-2-enyl)stannanes and Aldehydes promoted by Lewis Acids

Field: Chemistry (Physical Sciences)

The (5-benzylthiopent-2-enyl)stannane 3 after transmetallation with tin(IV) bromide or chloride generates an intermediate allyltin trihalide which reacts with aldehydes with useful levels of 1,5-asymmetric induction.
Using the Social–Ecological Model to Assess Vaccine Hesitancy and Refusal in a Highly Religious Lower–Middle-Income Country

Field: Social Sciences (Social Sciences)

(1) Background: The aim of this study was to understand the factors associated with vaccine hesitancy and refusal in Indonesia using the Social–Ecological Model (SEM). (2) Methods: Data on demographics, religiosity, family dynamics, and perceptions of public health efforts were collected through an online survey and compared to the rates of vaccine hesitancy and refusal. (3) Results: Income and sex were significantly associated with vaccine hesitancy. Based on a vaccine passport policy to enter public spaces, people who felt inhibited to enter public spaces or perceived privacy threats were twice as likely to exhibit vaccine hesitancy. Participants who believed that religious groups had a difficult time getting vaccinated were nearly twice as likely to exhibit vaccine hesitancy and three times more likely to exhibit vaccine refusal. However, participants who believed in a higher religious power were 58% less likely to exhibit vaccine hesitancy. Religious leaders significantly influenced participants to make the decision regarding vaccination. Individuals with vaccine refusal were more than twice as likely to share information with others without fact-checking. Notably, structural barriers such as distance and transportation were most strongly associated with vaccine hesitancy and refusal. (4) Conclusion: Cultural factors play a significant role in vaccine hesitancy and refusal. The SEM can be used to propose multi-level interventions with collaboration and communication among stakeholders to improve community health.
Movement Preparation and the Costs and Benefits Associated with Advance Information for Adults with Down Syndrome

Field: Psychology (Social Sciences)

This study examined the extent to which individuals with Down syndrome benefit from visual and verbal advance information about a manual aiming movement. Adults with Down syndrome as well as control subjects with and without mental handicaps performed 10.5-cm manual aiming movements with their preferred hand. On each trial subjects were cued about the specific movement either visually or verbally. On different trial blocks, the cue provided either 50% or 80% certainty. Nonhandicapped control subjects initiated and completed their manual aiming movements more quickly than subjects with mental handicaps. As well, individuals with Down syndrome were found to be slower and more variable in reaction time than participants in the other mentally handicapped group when valid information was provided verbally but not when the cue was provided visually. These results are consistent with the proposal that atypical hemispheric lateralization for speech perception associated with Down syndrome disrupts communication between functional systems responsible for processing of verbal language and organizing movement (Elliott & Weeks, 1993b).
Atwood's machine

Field: Physics and Astronomy (Physical Sciences)

Atwood's machine Get access J. F. M. J. F. M. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 180, Issue 17, 26 April 1941, Page 302, https://doi.org/10.1093/nq/180.17.302g Published: 26 April 1941
Herbogenomics: From Traditional Chinese Medicine to Novel Therapeutics

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Traditional Chinese medicine (TCM) has a long history of development and application and has demonstrated on evidence basis its efficacy in the treatment of many diseases affecting multiple organ systems. In particular, TCM is effective in the prevention and treatment of chronic diseases and metabolic syndromes. However, the value of TCM has not been fully recognized worldwide due to the lack of definitive information of active ingredients in almost any TCM preparation. Novel functional genomics and proteomics approaches provide alternate perspectives on the mechanism of action of TCM. The target molecules on which TCM either activates or inactivates can be identified by functional genomics and proteomics, thus the affected critical signaling pathway cascades leading to effective recovery of chronic diseases can be studied. Several TCM preparations have been available for the treatment of liver fibrosis and cirrhosis, even advanced liver cirrhosis that has been shown to be irreversible and has no US-FDA approved therapy. In the TCM-treated livers with fibrosis and cirrhosis, some critical molecules that are significantly involved in the recovery can be identified through functional genomics and proteomics studies. These molecules become novel targets for drug discovery and development and candidates for the development of gene therapy. Gene therapy developed based on this strategy for the treatment of advanced liver fibrosis and cirrhosis in animal models has obtained promising results. This process thus establishes a herbogenomics approach to understand mechanisms of action of TCM and to identify effective molecular targets for the discovery and development of novel therapeutics.
Endoscopic and Surgical Management of Intrabiliary Rupture of Hydatid Liver Cyst

Field: Medicine (Health Sciences)

A man with hydatid disease complicated by intraabdominal cyst rupture 15 years earlier, presented with cholestatic jaundice. There was intrabiliary rupture of a hydatid liver cyst on endoscopic retrograde cholangiography. Sphincterotomy was performed allow clearance of hydatid material obstructing the bile ducts and insertion of a nasobiliary catheter for irrigation and drainage. Definitive surgery was performed. While endoscopic management is gaining recognition for relieving biliary obstruction in hydatid cystobiliary rupture, surgery is still required for patients who continue to pass hydatid debris obstructing the biliary tree and increasing the risk of cholangitis.
Mass Media in The Socialization of E-Government Policiesabout Online Electronic Applications Services (E- Open)

Field: Social Sciences (Social Sciences)

The purpose of this study was written to find out about the mass media of e-government policy socialization through online service electronic applications (E-OPEN) at the Bekasi City population and civil registration service. The focus in this research is on the mass media socialization of e-government policies through electronic online service applications (E-OPEN) at the Bekasi City population and civil registration service. This paper is the result of research using a descriptive qualitative approach. Data collection techniques that researchers use are literature studies and field studies which are divided into three, namely observation, interviews and documentation. The technique for determining informants in this study used a purposive technique, starting from the head of the Bekasi City Disdukcapil planning department, the apparatus and admins who manage the Bekasi City Disdukcapil E-OPEN application to the public using the E-OPEN application to obtain information about mass media policy outreach to the application. E-OPEN. The results of this study indicate that the mass media used in disseminating E-Government policies through Electronic Online Services (E-OPEN) applications include Instagram @disdukcapilkotabekasi, Twitter @Disdukcapil2, Youtube Disdukcapil Kota Bekasi, Website https://disdukcapil.bekasikota. go.id. The existence of this mass media provides benefits for the people of Bekasi regarding the policies issued by the Bekasi City Government.
Bilateral total hip arthroplasty through minimally invasive direct anterior approach after Legg-Calvé-Perthes disease.

Field: Medicine (Health Sciences)

Bilateral secondary osteoarthritis of the hip may affect also young patients following bilateral hip diseases such as slipped capital femoral epiphysis and developmental hip dysplasia. We report the case of an 18- year old male with a previous diagnosis of Legg-Calvé-Perthes disease who underwent a bilateral total hip arthroplasty through minimally invasive direct anterior approach, with optimal results at 1-year follow up.
8. Cooking and Multiculturalism, Living Lab and Fab Lab: Collaborative Strategies in the Province of Barcelona Municipal Library Network

Field: Social Sciences (Social Sciences)

Libraries today create content through a mix of programming, workshops and innovative spaces: digital manufacturing workshops (fab labs), research and innovation centres (living labs), centres for performing arts and even kitchens. From a spatial point of view, these creative uses are changing the architecture of libraries. Libraries offer spaces designed to encourage collaboration and dialogue between users. This paper presents three very different projects in Barcelona, Spain in which collaborative strategies with external partners have generated inventive uses in libraries: cooking and multiculturalism in the Library of Fondo (Santa Coloma de Gramenet), the Living Lab in the Library of Volpelleres (Sant Cugat del Valles) and a Fab Lab in the Library of Les Corts (Barcelona).
Equities of scope as merger incentives under capital regulation: narrow versus synergy banking valuation

Field: Economics, Econometrics and Finance (Social Sciences)

The call options theory of corporate security valuation is applied to narrow-banking contingent claims of one bank, while the cap options theory is applied to synergy-banking contingent claims of another bank. This article investigates efficiency gains specified as equities of scope associated with the likelihood of the two banks involved in merger under capital regulation. We find that merger incentives are encouraged when the narrowing banking is conducted by the consolidated bank, whereas discouraged when the synergy banking is conducted. Raising bank capital requirement leads to an increased interest margin of the consolidated bank with the narrow banking valuation; however, to a decreased margin of the consolidated bank with the synergy banking valuation. An increase in the capital regulation reduces the merger incentives in the narrow banking valuation whereas increases the merger disincentive in the synergy banking valuation. These findings are consistent with the organizational theory that predicts a comparative advantage of narrow banking proposals in bank mergers.
Humanitarian aid of the European Union and United Nations: actions, responsibilities, and finances

Field: Social Sciences (Social Sciences)

Abstract The main purpose of the article is to analyze humanitarian aid provided by the European Union and the United Nations. The research includes a review of existing documents, reports, and studies on world humanitarian assistance. The main issues and findings analyzed in this study are the evolution of the humanitarian assistance provided by the European Union and the United Nations and the role of the European Community Humanitarian Aid Office – ECHO and the Office for Coordination of Humanitarian Affairs - OCHA – as units responsible for organization and financial issues. On the basis of the history and key events, the finances, and significant projects in the field of humanitarian aid implemented by the EU and the UN are presented. Finally, the authors attempt to assess the effectiveness of assistance.
NovelSOX17frameshift mutations in endometrial cancer are functionally distinct from recurrent missense mutations

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Extensive genomic profiling for endometrioid endometrial carcinoma (EEC) has pointed to genes and pathways important in uterine development as critical mediators of endometrial tumorigenesis. SOX17 is a developmental transcription factor necessary for proper endoderm formation that has been implicated as a tumor suppressor and shown to modulate WNT signaling. SOX17 mutation analysis in 539 primary EECs revealed frequent missense and frameshift mutations with an overall 11.5% mutation rate. More than half the mutations identified were frameshifts (32 of 62), and the hotspot missense changes, p.Ala96Gly and p.Ser403Ile, were seen in 14 tumors. None of the cases with a mutation had a second SOX17 mutation or evidence of allelic loss. Immunofluorescence microscopy performed on primary samples showed that there were no changes in SOX17 protein expression associated with mutation. Low/absent SOX17 staining was significantly associated with advanced stage, high tumor grade and reduced recurrence-free survival. Functional assessment of the two hotspot missense mutations and three representative frameshift mutations showed that SOX17-A96G and SOX17-S403I have transcriptional activities similar to SOX17 wild-type (WT), whereas none of the frameshift mutant proteins showed transcriptional activity. Forced expression of SOX17-WT, -A96G or -S403I in EC cell lines moderately increased β-catenin mediated transcription, which contrasts with previous data showing SOX17 is an inhibitor of TCF/β-catenin signaling. The proliferation of EC cell lines was expectedly reduced by transfection with SOX17-WT, and further reduced by SOX17-A96G and SOX17-S403I. These data implicate SOX17 mutation as a selected event in EEC, with clear differences between the missense and frameshift mutations.
Supplementary Figure 1 from <i>GSTP1</i> Promoter Haplotypes Affect DNA Methylation Levels and Promoter Activity in Breast Carcinomas

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Supplementary Figure 1 from <i>GSTP1</i> Promoter Haplotypes Affect DNA Methylation Levels and Promoter Activity in Breast Carcinomas
Characterization of Epitaxial Films by X-Ray Diffraction

Field: Materials Science (Physical Sciences)

Abstract In this paper, the application of recently developed x-ray diffraction techniques to the characterization of thin epitaxial films will be discussed. The double-crystal diffractometer, with high resolution in the non-dispersive arrangement, enables the materials scientist to study epitaxial systems having a very small mismatch with high precision. A key part of the characterization of an epitaxial film is the determination of the strain tensor by measuring lattice spacing! in various directions The determination of strain and composition profiles in ion-implanted films, epitaxial layers and superlattices by rocking-curve analysis will also be reviewed. Grazingincidence diffraction, an emerging new technique, can be used to obtain structural details parallel to the interface on films with thicknesses ranging down to a few atomic layers. The synchroton has now become increasingly available as a powerful source of x radiation which will facilitate the application of conventional and grazing-incidence diffraction to ultra-thin films.
Re-viewing Sovereignty, North Korean Authoritarianism, and Art

Field: Arts and Humanities (Social Sciences)

Emerging research on North Korean art mainly reads North Korean art, art theory, and art institutions for the roles they play in sustaining a North Korean authoritarian political system. To counter this trend, I turn to North Korean art and art/political theory to critique the deployment of authoritarianism in international research on North Korea and more fundamentally, to interrogate prevailing conceptions of sovereignty that feed into contemporary international interventionist practices. I begin by both problematizing the hierarchy in international politics that the authoritarian framework reifies and illustrating how North Korean juche ideology can be read to complicate how sovereign relations work, feel, and look in North Korea and beyond. I turn my analytical focus to North Korean paintings that circulate globally, and in particular the case of the 2010 MAK exhibition in Vienna. Rather than conceiving of art and art spaces as new arenas for bringing change into North Korea, I argue that these emerging sites that bring new actors, institutions, and traditions in contact should be viewed as intercultural sites for shiftings in sovereign politics through North Korea. My argument is that reinterpretation of North Korean political ideology and ways of reading North Korean art have major implications for reimagining sovereign relations in a post-Cold War, postcolonial era.
Recommendation: Computational prediction of ω-transaminase selectivity by deep learning analysis of molecular dynamics trajectories — R0/PR3

Field: Computer Science (Physical Sciences)

We previously presented a computational protocol to predict the enzymatic (enantio)selectivity of an ω-transaminase towards a set of ligands (Ramírez-Palacios et al. (2021) Journal of Chemical Information and Modeling 61(11), 5569–5580) by counting the number of binding poses present in molecular dynamics (MD) simulations that met a defined set of geometric criteria. The geometric criteria consisted of a hand-crafted set of distances, angles and dihedrals deemed to be important for the enzymatic reaction to take place. In this work, the MD trajectories are reanalysed using a deep-learning approach to predict the enantiopreference of the enzyme without the need for hand-crafted criteria. We show that a convolutional neural network is capable of classifying the trajectories as belonging to the 'reactive' or 'non-reactive' enantiomer (binary classification) with a good accuracy (>0.90). The new method reduces the computational cost of the methodology, because it does not necessitate the sampling approach from the previous work. We also show that analysing how neural networks reach specific decisions can aid hand-crafted approaches (e.g. definition of near-attack conformations, or binding poses).
Phytochemical Profile and Antioxidant Potential of Berberis aristata Bark in Diabetes Mellitus Management

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Diabetes mellitus is a long known metabolic disorder that is afflicting millions of people all over the world. High levels of blood sugar (also known as glucose) in the blood that can develop into other health problems if untreated, this is the main feature. In this case the body cannot make enough insulin to regulate blood sugar or does not use insulin properly. Diabetes have two types, i.e. diabetes 1st type and diabetes 2nd type. Chronic diseases both are called diabetes that affect how glucose is processed in the body causing blood sugar levels to be high. They however have different causes, symptoms, and treatment options.A plant of the Berberidaceae family, Berberis aristata is often called Indian Barberry or Tree Turmeric. The traditional use of Berberis aristata has been very long. One of its many active ingredients, berberine has shown antimicrobial, anti inflammatory as well as antioxidant and antidiabetic properties. The plant is used for treating numerous medical conditions, e.g. digestive problems, respiratory infections, skin conditions, diabetes. The Berberis aristata in ayurvedic medicine is used in diabetes and diabetes related complications. It is understood to improve insulin sensitivity and to promote glucose uptake by the cells to help with blood sugar levels. Berberis aristata is a long traditional medicine. Antimicrobial, antidiabetic, antioxidant and anti-inflammatory properties have been demonstrated for one of its many active ingredients, berberine, although it is not believed to be the most important one when it comes to diabetes. The plant is used for treatment of numerous medical conditions such as digestive, respiratory infection, skin, and diabetes. Keywords: Diabetes mellitus, Antioxidant, Berberine, Berberis aristata
Evaluation of the risk of cervical intraepithelial neoplasia and human papilloma virus infection in renal transplant patients receiving immunosuppressive therapy.

Field: Medicine (Health Sciences)

Renal transplant patients who were undergoing immunosuppressive therapy were found to be at increased risk of developing cervical intraepithelial neoplasia. All the patients using immunosuppressive agents should be followed-up by Pap smears every six months and by colposcopic evaluation every year. Avoiding high-risk sexual acts will decrease the risk of HPV transmission and the risk of genital neoplasia as well.
A versatile fiber laser delivering dispersion-managed soliton and Q-switched pulse

Field: Engineering (Physical Sciences)

In this work, we present a novel versatile fiber laser based on the scheme of bidirectional transmission, with a nonlinear optical loop mirror (NOLM) and a graphene-polyvinyl alcohol (G-PVA) as saturable absorbers (SAs), and demonstrate the generation of dispersion-managed soliton (DMS) and Q-switched pulse simultaneously or respectively for the first time to the best of our knowledge. In counter-clockwise (CCW) direction, the G-PVA is acted as a slow SA and used for obtaining Q-switched pulse trains, the DMS is achieved in clockwise (CW) direction by using NOLM. The proposed fiber laser can be switched in three cases by simply adjusting attenuator (ATT), pump power and polarizer controllers (PCs): (I) Only DMS is obtained. (II) Only Q-switched pulse trains are achieved. (III) The DMS and Q-switched pulse trains are established simultaneously. This versatile laser enables to generate two kinds of pulse, which is a potential candidate in communication system and industrial applications.