jimnoneill/paper-to-field-training huggingface dataset:
The role of hmga2 on parp1 activity in triple-negative breast cancer cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

PARP inhibitors have shown promising results in combination with DNA damaging drugs and studies on the use of PARP inhibitors in combination with other treatments are ongoing for TNBC patients. The non-histone chromatin binding protein HMGA2 is expressed in embryonic stem cells and cancer cells, including triple-negative breast cancer cells (TNBC). HMGA2 enhances resistance to chemotherapeutics by enhancing base excision repair (BER) capability and decreases apoptosis by modulating the ATM and ATR DNA damage signaling pathways. Here we hypothesized that HMGA2 increases DNA damage-induced PARP1 activity and increases survival and of TNBC cells. I demonstrated that HMGA2 reduced MMS-induced DNA damage, increased cell survival and reduced apoptosis in triple-negative cancer cells. We identified PARP, an ADP-ribosylating enzyme recruited to DNA damage sites, as a novel HMGA2-interaction partner and showed that PARP1 activity was increased in the presence of HMGA2. This required functional AT hook domains of HMGA2. HMGA2 reduced the sensitivity of triple-negative breast cancer cells towards PARP1 inhibitors. Silencing of HMGA2 resulted in decreased cell survival and increased apoptosis following treatment with MMS and Olaparib. In conclusion, we identified for the first time HMGA2 as a novel regulator of PARP1 activity in cancer cells causing a reduced sensitivity towards PARP1 inhibitors. This suggests that HMGA2 may be a promising new target for combinatorial therapies in using PARP inhibitors in HMGA2-positive tumors.
Graphene oxide based plasmonic nano-cavity sensor for high-performance refractive index sensing

Field: Materials Science (Physical Sciences)

Abstract In this work, a nano-cavity based metal-insulator-metal structure is proposed which can be used as a high-performance refractive index sensor. The analysis of its sensing capabilities is done by determining the transmission characteristics of light through the insulating air channel between the metal layer. The loss in transmission in this channel is indicative of light leaking out of it and portion of it getting coupled to nano-cavities considered in the metal layers on both sides of the air channel. The analyte, whose refractive index is to be sensed, is kept in these nano-cavities. The basic structure is modified by introducing graphene oxide (GO) on the inner wall of the nano-cavity, which further improves the confinement of light in the nano-cavities. It is also shown that increasing the number of nano-cavity duos enhances the transmission loss through the waveguide and as a result the light energy confinement in the cavity increases. Calculated values of sensitivities and Figure of Merit of the proposed sensor structure are much higher than similar works done previously. The uniqueness of the work is two-fold; namely use of graphene oxide as an inner layer of the nano-cavity improves the sensitivity of the sensor and secondly calculating the waveguide transmission to indirectly determine the confinement of light energy in nano-cavity simplifies the analysis of the performance of the proposed sensor. The structure is simple and can be easily fabricated using a standard fabrication process.
Spin transport in the Quantum Spin Liquid State in the $S=1$ Kitaev model: role of the fractionalized quasiparticles

Field: Physics and Astronomy (Physical Sciences)

We investigate the real-time spin response of the $S=1$ Kitaev model upon stimuli of a pulsed magnetic field in one of the edges using the exact diagonalization method. It is found that the pulsed magnetic field has no effect on the appearance of the spin moments in the quantum spin liquid region, but induces the spin oscillations in the other edge region with a small magnetic field. This is understood by the existence of the itinerant quasiparticles, which carry the spin excitations without the spin polarization in the quantum spin liquid state. This suggests that the spin fractionalizations occur in the $S=1$ Kitaev model as well as the exactly solvable $S=1/2$ Kitaev one and the fractionalized quasiparticles play an essential role in the spin transport.
Comparative Study on the Impact of Talent Cultivation Policies on the Quality of Higher Vocational Education

Field: Social Sciences (Social Sciences)

As economic and social development progresses, higher vocational education plays an increasingly crucial role in cultivating various talents, driving economic growth, and advancing societal progress. However, differences in talent cultivation policies across regions affect the quality of higher vocational education in diverse ways. By comparing the implementation and impact of talent cultivation policies in different regions, this study aims to provide significant references and lessons for enhancing the quality of higher vocational education.
Lipschitz regularity for degenerate elliptic integrals with 𝑝, 𝑞-growth

Field: Mathematics (Physical Sciences)

Abstract We establish the local Lipschitz continuity and the higher differentiability of vector-valued local minimizers of a class of energy integrals of the Calculus of Variations. The main novelty is that we deal with possibly degenerate energy densities with respect to the 𝑥-variable.
Manajemen Pendidikan Karakter PAUD Terpadu ‘Aisyiyah Nur’aini Ngampilan Yogyakarta

Field: Social Sciences (Social Sciences)

Children is a state asset which will be the successor to the nation in the future, so that in the formation of character is the most important thing at early childhood education. From that problem, the management of character education in early childhood education (ECD) at PAUD Terpadu 'Aisyiyah Nur'aini by the planning, actuating, monitoring and coaching. Character values ​​embedded in early childhood are 15 character values. Factors that influence the character education management in early childhood can be seen with the SWOT analysis and found to external factors (opportunities and threats) and internal (strengths and weaknesses). Furthermore, the impact of early childhood education management in the characters that can be seen in the future, but there is some value character that has an effect on positive behavior change and polite language and thought patterns are changing for the better, so that the child is directed when in school and at home.
Strategies for posterior-only minimally invasive surgery in thoracolumbar metastatic epidural spinal cord compression

Field: Medicine (Health Sciences)

Background: Metastatic epidural spinal cord compression (MESCC) is a debilitating sequela of cancer. Here, we evaluated various subtypes of posterior-only minimally invasive spinal (MIS) procedures utilized to address different cancers. Methods: Within this retrospective review, we analyzed the treatment of thoracolumbar MESCC treated with three MIS techniques: decompression and fusion (Subgroup A), partial corpectomy (Subgroup B), and full corpectomy (Subgroup C). Results: There were 51 patients included in the study; they averaged 58.7 years of age, and 51% were females. Most tumors were in the thoracic spine (51%). The average preoperative Frankel grade was D (62.7%); 69% (35) improved postoperatively. The patients were divided as follows: subgroup A (15 patients = 29.4%), B (19 patients = 37.3%), and C (17 patients = 33.3%). The length of hospitalization was similar (~5.4 days) for all groups. The overall complication rate was 31%, while blood loss was lower in Subgroups A and B versus C. Conclusion: Different MIS surgical techniques were utilized in patients with thoracic and/or lumbar MESCC. Interestingly, clinical outcomes were similar between MIS subgroups, in this study, with a trend toward higher complications and greater blood loss associated with those undergoing more aggressive MIS procedures (e.g., full corpectomy and fusion).
Ethical decision-making of accounting students : evidence from an Australian setting

Field: Business, Management and Accounting (Social Sciences)

This study investigates accounting students&#039; ethical decision-making judgments and behavioral intentions. The Multidimensional Ethics Scale (MES) was used to measure the extent to which a hypothetical behavior was consistent with three moral criteria (Moral Equity, Relativism and Contractualism). The study specifically tests the differences in ethical decision-making between students who have been exposed to a dedicated ethics unit of study compared with students who have not studied ethics. The influences of culture and gender on students&#039; ethical decision-making are also addressed in the study. Ethical decision-making was assessed via three case studies describing moral dilemmas that an individual, business or professional person might face. The results provide support for the MES and the value added from incorporating a dedicated ethical decision-making unit in the accounting curriculum. The results also support prior evidence of gender bias and the impact of cultural differences on ethical decision-making.
Secrecy motifs and messianic consciousness in the First Gospel: Pre-Easter tradition and historicity vis-a-vis the theological agenda of Mark and the early Church

Field: Arts and Humanities (Social Sciences)

The following study is an exploration of the possible traditions utilized by the author of the Gospel of Mark as they relate to an acknowledged theme of secret messiahship. A survey of the socio-historical evidence as well as the textual evidence for and against an authentic messianic consciousness on the part of Jesus of Nazareth is also presented. The primary thesis of the following discussion is that an historical concealing of Jesus' divine identity would necessarily entail at least some degree of messianic consciousness. However the inverse, that an authentic messianic consciousness would entail an authentic "messianic secret", is not true.\nTo begin, a general discussion of the recognized aspects of the "messianic secret" is given. Two of the most influential scholars of Markan studies, Wilhelm Wrede and Albert Schweitzer, are compared and contrasted as well as criticized. Schweitzer's view of the secrecy texts in Mark seems to be more worthwhile to pursue since his theory is more flexible than Wrede's all-pervasive perspective. An attempt to delineate the historical Jesus from his contemporary miracle workers is also carried out, with help from a prominent study by Theodore Weeden. Jesus' activity as a demon exorcist as it relates to his identity, with particular emphasis on Peter's confession at Caesarea Philippi, is also presented. The injunction to silence given by Jesus in Mark 9:9 after he is transfigured is acknowledged to be of great importance in analyzing the secrecy texts. An in-depth analysis of T.A. Burkill and Austin Farrer is undertaken. Burkill relates the theme of secrecy to a preordained divine plan, while Farrer views it in a paradigm of prefiguration and fulfillment.\nThe study concludes with the assertion that the author of the First Gospel could have operated with authentic traditions about Jesus and used them to serve a meaningful literary function to aid his unique theological portrait of Jesus, all the while supporting the greater theme of suffering messiahship and suffering discipleship. The evidence points toward a messianic consciousness during Jesus' lifetime. If the injunctions to silence indeed originated in Jesus' own thoughts, it was probably a result of Jesus' personal eschatology regarding his own identity and that of the Son of Man.
LHD lhdcxs9b-sif #135775.1

Field: Physics and Astronomy (Physical Sciences)

Charge eXchange Spectroscopy (CXS) system, which consists of diagnostic beam, object lens, optical fiber bundle array, spectrometer, CCD detector and controllers, to measure radial profiles of ion temperature, poloidal/toroidal plasma rotation velocities, and impurity density (carbon or helium) using charge exchange collisions between neutral beam and impurities.
Musical emotions in the brain-a neurophysiological study.

Field: Neuroscience (Life Sciences)

Introduction: Music has accompanied our evolution ever since the dawn of mankind. This project was designed to bridge the connection between music and emotions in our brain. Objectives: The purpose of this analysis is to relate the emotions felt by the participants to the recording of brain electrical activity simultaneously. The article will report the activation of the EEG rhythm bands in our brain and draw conclusions about the areas most affected by music and the emotions mentioned by the participants. Methods: Thirty college students were monitored with EEG recording while subjected to the audition of different excerpts of music, each one associated with a different emotion: joy, sadness, fear and anger. The evoked emotions were evaluated through behavioural ratings and the EEG was recorded with an electrode cap in order to collect electroencephalography data in 13 channels with reference to the mastoids. The findings were fully analysed and compared to their rest recordings. Results: The predominance of left hemisphere activation with pleasant feelings and right activation with unpleasant ones was notorious. The excerpt that transmitted positive valence emotions (joy) demonstrated asymmetry in the alpha band predominantly in the left central and parietal lobe while the excerpts that induced unpleasant emotions (sadness and fear) were associated with an increased coherent activity towards the right frontal-temporal regions. Plus, there was an association between emotions that provoke a behavioural approach (joy and anger) and the left-sided areas of the brain and between the emotions that cause withdrawal behaviour (sadness and fear) and the right hemisphere. Conclusion: This investigation led to the recruitment of several networks in the brain electrical activity through the EEG involved in the processing of music, transporting us into the emotions’ world. We conclude that there is a noticeable relation between the music and the emotions felt, having great influence in the patterns of cerebral activation.
Recruitment and Retention of African American and Hispanic Girls and Women in Research

Field: Health Professions (Health Sciences)

Abstract Recruiting women and girls into research studies, especially minority women, continues to be a major challenge that impacts health policy and delivery systems. This article discusses various strategies to recruit and retain A frican A merican and H ispanic girls and women in studies. Strategies for successful recruitment focus on trust, familiarity and visibility, racial and ethnic similarities, environmental context, and convenience. Retention strategies include issues of transportation, language, literacy, cultural appropriateness, safety, flexibility, incentives, communication, and veracity. All strategies assist in meeting the challenge of engaging minority women in research to decrease health disparities.
Adolescents Educated in Israel and in the Soviet Union

Field: Social Sciences (Social Sciences)

Moral judgments on a relativistic-realistic dimension of two groups of adolescents were measured. One hundred Israeli- and 100 Soviet-educated adolescents who had recently arrived in Israel were given a specially designed instrument—the Morality Shifting in Adolescence Questionnaire. Soviet-educated adolescents were significantly more realistically oriented in their moral judgment than the Israelis. It was also found that, in both groups, girls were more realistically oriented than boys. The proposed explanation related these differences to the different socialization processes in the two countries.
Pediatric Ependymoma: Biological Perspectives

Field: Medicine (Health Sciences)

Abstract Pediatric ependymomas are enigmatic tumors that continue to present a clinical management challenge despite advances in neurosurgery, neuroimaging techniques, and radiation therapy. Difficulty in predicting tumor behavior from clinical and histological factors has shifted the focus to the molecular and cellular biology of ependymoma in order to identify new correlates of disease outcome and novel therapeutic targets. This article reviews our current understanding of pediatric ependymoma biology and includes a meta-analysis of all comparative genomic hybridization (CGH) studies done on primary ependymomas to date, examining more than 300 tumors. From this meta-analysis and a review of the literature, we show that ependymomas in children exhibit a different genomic profile to those in adults and reinforce the evidence that ependymomas from different locations within the central nervous system (CNS) are distinguishable at a genomic level. Potential biological markers of prognosis in pediatric ependymoma are assessed and the ependymoma cancer stem cell hypothesis is highlighted with respect to tumor resistance and recurrence. We also discuss the shifting paradigm for treatment modalities in ependymoma that target molecular alterations in tumor-initiating cell populations. (Mol Cancer Res 2009;7(6):765–86)
ceftriaxone MICs for Streptococcus pneumoniae

Field: Medicine (Health Sciences)

In a recent article in this Journal, Caniça et al.1 reported in vitro activities for extended-spectrum cephalosporins tested against 384 isolates of Streptococcus pneumoniae with reduced susceptibility to penicillin. As the authors state, data such as these are essential because cefotaxime and ceftriaxone are important antimicrobial agents for the treatment of pneumo-coccal infections, and of particular importance for the treat-ment of patients with pneumococcal meningitis. Previous publications have reported that 1–3 % of pneumococcal isolates submitted to clinical microbiology laboratories in the United States are from CSF specimens, compared with 97–99 % of pneumococci from respiratory, blood and other specimen sources.2,3 Based on published studies, Caniça et al.1 noted that isolates of S. pneumoniae resistant to third-generation cephalosporins remain rare, whereas other
Critical success factors for value management techniques in construction projects: case in Jordan

Field: Engineering (Physical Sciences)

This study aims to identify the critical success factors (CSFs) of Value Management (VM) in construction projects in the context of developing countries. The article serves as a preliminary study on the status of VM in developing countries. A questionnaire survey and interviews with construction professionals have been conducted to highlight possible success factors to achieve this aim. The 181 returned surveys were analysed using factor analysis to explore the inherent relationships between the highly ranked CSFs. The study reveals that Client Support, Awareness of the VM team, the VM facilitator's proficiency, and the VM team environment are the main clusters that describe the connections between CSFs. Besides the scarcity of VM studies in developing countries, our study provides insights into how VM techniques can be smoothed in construction projects. Additionally, the article introduces two novels CSFs to the field of VM that has not been investigated before.
Eosinophilic Granuloma of Bone

Field: Medicine (Health Sciences)

1. Twenty-eight cases of eosinophilic granuloma of bone in children and adults, all but one with symptomatically solitary lesions, are reported. The skull, femur, ribs, and mandible were the most frequent sites of involvement. 2. No diagnostic roentgenographic characteristics were found. Lesions of the flat bones were generally punched-out osteolytic lesions. Lesions of long bones were easily confused with malignant tumors. Biopsy is considered imperative to establish the diagnosis. 3. Transition of eosinophilic granuloma to Hand-Schüller-Christian disease or Abt-Letterer-Siwe syndrome has not been encountered in these cases and we have some doubts whether the reported cases of transition represent true changes from one form to another. 4. Therapy has included excision, curettage, small doses of irradiation, or nothing. Evaluation of any one form of treatment is impossible. All the lesions reported in this study healed regardless of the therapy. 5. Meticulous microbiological studies of the tissue from these lesions seem indicated.
Modification of the Intestinal Microbiota with Enterobacteriaceae-specific Oligonucleotide Antimicrobials as a Novel Approach to Improve Metabolic Health

Field: Immunology and Microbiology (Life Sciences)

Imbalances in the microbiota due to overgrowth of Enterobacteriaceae is associated with numerous metabolic conditionsmost notably obesity. We describe an oligonucleotide antimicrobial, Transcription Factor Decoys (TFDs) that competitively inhibit the Crp-FNR transcription factor highly conserved amongst Enterobacteriaceae and is critical for the regulation of stress response and survival under anaerobic conditions. A nanoparticulate formulation delivers the TFDs to the cytoplasm of E. coli, as visualised by confocal microscopy, rapidly reduced viable bacteria under anaerobic conditions. In vitro data showed FNR TFD decreased up to log10 6 CFU/ml of coliforms within the Enterobacteriaceae family while other families remained relatively undisturbed; similarly when delivered orally to wild-type mice in vivo, Enterobacteriaceae were significantly reduced while other key bacterial populations were unaffected. This demonstrates that TFDs can be used to make precise changes to the microbiota and has utility in testing associations between dysbiosis and disease potentially leading to the development of microbiota targeted therapeutics to tackle obesity.
Contribution of Hydrolase and Phosphatase Domains in Soluble Epoxide Hydrolase to Vascular Endothelial Growth Factor Expression and Cell Growth

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Soluble epoxide hydrolase (sEH) is an important pharmacological target because it metabolizes potent bioactive substrates, epoxyeicosatrienoinc acids (EETs) and other lipid epoxide. EETs have a variety of biological functions including angiogenesis and cancer metastasis. However, the regulation and physiological function of sEH is not well understood. In this study, we found that hypoxia significantly suppressed the expression of sEH in mouse liver and a human hepatoma cell line, Hep3B. Hypoxia promotes the proliferation of vascular endothelial cells or carcinoma cells. Knockdown of sEH in Hep3B cells induced vascular endothelial growth factor (VEGF) mRNA and cell growth, both of which were suppressed by overexpression of sEH. sEH has phosphatase activity as well as epoxide hydrolase (EH) activity. We prepared mutant clones which lacking EH or phosphatase activity using the amino acid change Asp335Ser or Asp9Ala, respectively. The effects of WT sEH on cell growth were lost by mutation of either the EH domain or phosphatase domain. However, mutation of the phosphatase domain but not EH domain did not influence the expression of VEGF. These results suggest that sEH plays an important role in the physiology of cells including proliferation and that the epoxide hydrolase and phosphatase domains of sEH have different biological functions.