jimnoneill/paper-to-field-training huggingface dataset:
Treatment outcome of immune thrombocytopenia

Field: Medicine (Health Sciences)

Introduction: Treatment of immune thrombocytopenia is sometimes difficult and needs personal setting. According to evidence-based guidelines, corticosteroids are suggested for first-line treatment. In case of corticosteroid ineffectiveness, second-line therapeutic options (splenectomy, immunosuppressive drugs and, recently, thrombopoietin-mimetics) may result in beneficial therapeutic effect. Aims: The aim of the authors was to examine the clinicopathological data, disease course, treatment results, and the effectiveness of novel drugs in patients with immune thrombocytopenia. Patients and methods: The authors retrospectively analysed the files of 79 immune thrombocytopenic patients (26 males and 53 females) diagnosed and treated at the hematologic in- and outpatient units of the Markusovszky Hospital, County Vas, Hungary between January 1, 2000 and December 31, 2011. Remission rates, disease-free and overall survivals in response to corticosteroids (first-line treatment), after splenectomy (in cases when corticosteroids proved to be ineffective) and following second-line treatment were analysed. Survival curves were constructed using statistical software programs. Results: Of the 79 patients during a median follow-up of 66 months (min. 3, max. 144 months), 28 patients receiving first-line corticosteroids achieved complete remission and remained in a prolonged disease-free condition (35.4%; median disease-free survival 75.5 months; min. 2, max. 140 months). Thirty-eight patients underwent splenectomy after ineffective treatment with corticosteroids or other immunosuppressive (48.0%; median disease-free survival 94.2 months; min. 6, max. 136 months). Surgical complications occurred in 2 cases, while postoperative and late infections were absent. Five patients died but death was not related to immune thrombocytemia. Second-line treatment was applied in 13 patients (16.4%) and among these patients relapse of immune thrombocytopenia after splenectomy was observed in 6 patients. Favourable effects of both conventional (immunosuppressive) and novel treatments (rituximab, thrombopoietin-mimetics) were also detected. Conclusions: More than two-thirds of patients with immune thrombocytopenia responded to corticosteroids or to splenectomy and achieved prolonged disease-free remission. Novel drugs (rituximab, thrombopoietin-mimetics) applied only in few cases produced also favourable results in patients not responding to corticosteroids and splenectomy. Orv. Hetil., 2012, 153, 1613–1621.
Semantic Kernel Updating for Content-Based Image Retrieval,&quot; The IEEE International Conference on Authorized licensed use limited to: Murdoch University

Field: Computer Science (Physical Sciences)

A lot of relevance feedback methods have been pro-posed to deal with Content-Based Image Retrieval (CBIR) problems. Their goal is to interactively learn the seman-tic queries that users have in mind. Interaction is used to ll the gap between the semantic meaning and the low-level im-age representations. The purpose of this article is to analyze how to merge all the semantic information that users provided to the system during past retrieval sessions. We propose an approach to exploit the knowledge provided by user interaction based on binary annotations (relevant or irrelevant images). Such se-mantic annotations may be integrated in the similarity ma-trix of the database images. This similarity matrix is ana-lyzed in the kernel matrix framework. In this context, a ker-nel adaptation method is proposed, but taking care of pre-serving the properties of kernels. Using this approach, a se-mantic kernel is incrementally learnt. To deal with practical constraint implementations, an eigendecomposition of the whole matrix is considered, and a efcient scheme is proposed to compute a low-rank ap-proximated kernel matrix. It allows a strict control of the required memory space and of the algorithm complexity, which is linear to the database size. Experiments have been carried out on a large generalist database in order to validate the approach. 1.
Activating mutation in the c-MPL gene and FET

Field: Medicine (Health Sciences)

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

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Since the identification of the cellular homolog of viral oncogene v- mpl (c-MPL) and its ligand thrombopoietin (TPO) as major regulators of megakaryopoiesis and, hence, of circulating platelet numbers, several naturally occurring
On Becoming Themselves: The 1964–1968 Presidential Scholars 40 Years Later

Field: Psychology (Social Sciences)

Abstract Every year since 1964, approximately 120 high-school seniors have been selected for presidential recognition, from across the United States. As the first cohort of Presidential Scholars enters their 60s, we wanted to hear what they think about the roles that academic, professional, and personal achievement have played in their lives and to reconsider sex differences found in earlier studies. Our findings are reported here both as summary data of the responses of 145 Scholars from the 1964–1968 cohort and as selected excerpts, in their own words. Participants in this study share their wisdom about giftedness and talent as it develops across the life span and offer advice to parents, educators, and highly capable young people. They emphasize the importance of hard work, perseverance, and personal relationships and suggest that success is more about self-acceptance and personal fulfillment than it is about formal recognition and prizes. Keywords: achievementawardscontributionfollow-up studiesgiftedgifted adultsidentityPresidential Scholarsrecognitionsex differencestalent development
Chronic Appendicular Abscess Presenting as a Complex Adnexal Mass: A Case Report

Field: Medicine (Health Sciences)

Background: The authors present an unusual presentation of a chronic appendicular abscess. A 57-year-old presented to the emergency department with acute on chronic abdominal pain, worsening abdominal distention and decreased appetite. Abdominal imaging revealed the presence of a multi-septated cystic right adnexal mass concerning for metastatic ovarian carcinoma. Intra-operatively the diagnosis of a likely chronic ruptured appendix at the base of the colon was confirmed. In postmenopausal women the majority of adnexal masses are benign neoplasms, however, the risk of malignancy is much greater than in premenopausal women. Postmenopausal women with clinical symptoms and findings on diagnostic imaging suggestive of malignancy warrant expedited management. While imaging and biomarkers help to give insight into origin of masses and can aid in determining treatment, diagnostic operations may be ultimately required to achieve final diagnosis and direct further management.
Induced Mutations in Roses

Field: Agricultural and Biological Sciences (Life Sciences)

It has been possible to obtain mutations for flower colour in 3 cultivars of rose viz., ‘Christian Dior’ ‘Queen Elizabeth’ and ‘Kiss of Fire’ after gamma irradiation, which might be of direct commercial importance as they are found to deviate from other types. Five to ten kr of gamma rays has proved to be the best for treatment of dormant buds. Dormancy of buds is induced after both gamma irradiation and chemical treatments. 10 kr of gamma rays proved toxic to all the cultivars and treatments above this did not give survival under Delhi conditions. Chemical mutagens including NMU (N-nitroso-n-methyl urethane), EMS (Ethyl-methane-sulphonate), E.I. (Ethylene-imine) in different concentrations in combination with DMSO (Dimethyl sulfoxide) have been tried on growing plants. Dipping buds in NMU and EMS resulted in mutants for colour in ‘Christian Dior’ and reduction in petal number in ‘Kiss of Fire’ respectively.
Pareto's Theory of Choice

Field: Economics, Econometrics and Finance (Social Sciences)

Research Article| June 01 1998 Pareto's Theory of Choice Martin Gross; Martin Gross Search for other works by this author on: This Site Google Vincent J. Tarascio Vincent J. Tarascio Search for other works by this author on: This Site Google History of Political Economy (1998) 30 (2): 171–187. https://doi.org/10.1215/00182702-30-2-171 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Permissions Cite Icon Cite Search Site Citation Martin Gross, Vincent J. Tarascio; Pareto's Theory of Choice. History of Political Economy 1 June 1998; 30 (2): 171–187. doi: https://doi.org/10.1215/00182702-30-2-171 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsHistory of Political Economy Search Advanced Search The text of this article is only available as a PDF. Copyright © 1998 by Duke University Press1998 Article PDF first page preview Close Modal Issue Section: Articles You do not currently have access to this content.
Optimization of Physical Parameters of Fermentation Medium for Biosynthesis of Alginate by a Vinelandii Using Molasses as ‘C’ Source

Field: Chemical Engineering (Physical Sciences)

Biopolymer have varied industrial applications. Alginate is one such polymer conventionally extracted from brown algae of marine waters having versatile applications. Due to its increased market demand alternative options are being investigated for its synthesis from microbes. The present study focuses on the optimization of various physical parameters at flask level. Fermentation medium consisted of pre-treated sugar cane molasses (2%) as carbon source and peptone as nitrogen source (0.5 g). The optimized parameters were found to be, temperature as 30oC, pH 7.0, incubation period 84 hours, agitation rate 150 rpm, inoculum age 36 hours and inoculum level 5%. Under optimized parameters the significant (P<0.05) alginate yield was found to be 5.71 g/L (PS) and 6.28 g/L (MS) with the corresponding dry cell mass (DM) as 6.28 g/L (PS) and 6.92 g/L (MS). The plate assay of the alginate lyase activity indicated that the improved strain has less activity (11 mm) as compared to the parent strain (14 mm). Alginate lyases influence the yield and the molecular weight of the product. Hence the zone of hydrolysis on the plates correlates with the maximum yield obtained. HPLC chromatogram indicated the peak of purified alginate with retention time of 3.332 minutes with purity of 81.22 %.
MEDROBO: Automated Medicine Delivery and Patient Monitoring System

Field: Health Professions (Health Sciences)

The research aims to develop an innovative solution to automate the delivery of medicine to patients and monitor their vital parameters in healthcare facilities. Traditional methods often rely on human interventions for medicine delivery and patient monitoring, leading to inefficiencies and potential errors. To address these challenges, the proposed study introduces a robotic system capable of line-following method and real-time health parameter monitoring. The core functionality of the system revolves around a robot equipped with various sensors. The robot navigates hospital corridors by following predefined lines, allowing it to reach patients’ rooms without human assistance. RFID tags attached to patient beds facilitate the robot in identifying and locating specific patients, ensuring accurate medicine delivery. Furthermore, the robot integrates vital sign monitoring capabilities, including heart rate, Spo2, blood pressure, and temperature.
Fertility restoration analysis in different CMS sources in rice (Oryza sativa L.)

Field: Agricultural and Biological Sciences (Life Sciences)

Amongst 275 test crosses, 57.45 %, 7.27 %, 35.27 % and 21.09 % were observed as restorers, maintainers, partial restorer and partial maintainers respectively for all the CMS lines included in the study. The pollen and spikelet fertility in the test cross progenies ranged from 0.0 to 94.66 and 0.0 to 81.10 per cent, respectively. The highest pollen and spikelet fertility was observed in test cross; RTN 17A/Pusa-44 (94.66 and 89.10 %) followed by RTN 3 x PR-115 (94.43 and 87.29 %). Among 55 high yielding varieties/ promising lines, 47 genotypes exhibited fertility restoration for any one of the CMS line. Out of 47 genotypes, 14 varieties (25.45 %) were identified as common restorers for all the five CMS lines of five different sources. The frequency of the male parents behaving as effective restorers was found to be maximum (65.45 %) for RTN 2A of ARC source followed by RTN 17A (60.0 %) of Dissi source, KJTCMS-6A (56.36 %) of WA sources, RTN 3A (54.55 %) of Mutant of IR 62829B source and RTN 13A (50.91 %) of Gambiaca source indicating that the fertility in these CMS lines were easy to restore. The genotypes, viz., IR-8866, BL-184AR, IET-13840-RP-66-67, RDN-97-3-2-37-14, PR-115, PKV-Makarand, GR-7, IR-54742-22-19-3, Pusa Sugandha-3, Pusa Sugandh-5, Super basmati, Phule Radha, RP-BIO-226 and GR-11, NVSR-20, IR-63879-195-195-2-2-3-2, IR-22273 and PR-118 were identified as effective restorers may be exploited to develop commercial hybrids and the genotypes, viz., VDN-9-10-1, SYE-4, GR-4, Gurjari, SKL-8, IR-34, SYE-6, SYE-5 and GR-5 were identified as maintainers may be exploited for conversion of CMS sources in above said locally adaptable genotypes.
Table_9_Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic.xlsx

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Background<p>The recent emergence of COVID-19, rapid worldwide spread, and incomplete knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited development of therapeutic strategies. Our objective was to systematically investigate molecular regulatory mechanisms of COVID-19, using a combination of high throughput RNA-sequencing-based transcriptomics and systems biology approaches.</p>Methods<p>RNA-Seq data from peripheral blood mononuclear cells (PBMCs) of healthy persons, mild and severe 17 COVID-19 patients were analyzed to generate a gene expression matrix. Weighted gene co-expression network analysis (WGCNA) was used to identify co-expression modules in healthy samples as a reference set. For differential co-expression network analysis, module preservation and module-trait relationships approaches were used to identify key modules. Then, protein-protein interaction (PPI) networks, based on co-expressed hub genes, were constructed to identify hub genes/TFs with the highest information transfer (hub-high traffic genes) within candidate modules.</p>Results<p>Based on differential co-expression network analysis, connectivity patterns and network density, 72% (15 of 21) of modules identified in healthy samples were altered by SARS-CoV-2 infection. Therefore, SARS-CoV-2 caused systemic perturbations in host biological gene networks. In functional enrichment analysis, among 15 non-preserved modules and two significant highly-correlated modules (identified by MTRs), 9 modules were directly related to the host immune response and COVID-19 immunopathogenesis. Intriguingly, systemic investigation of SARS-CoV-2 infection identified signaling pathways and key genes/proteins associated with COVID-19’s main hallmarks, e.g., cytokine storm, respiratory distress syndrome (ARDS), acute lung injury (ALI), lymphopenia, coagulation disorders, thrombosis, and pregnancy complications, as well as comorbidities associated with COVID-19, e.g., asthma, diabetic complications, cardiovascular diseases (CVDs), liver disorders and acute kidney injury (AKI). Topological analysis with betweenness centrality (BC) identified 290 hub-high traffic genes, central in both co-expression and PPI networks. We also identified several transcriptional regulatory factors, including NFKB1, HIF1A, AHR, and TP53, with important immunoregulatory roles in SARS-CoV-2 infection. Moreover, several hub-high traffic genes, including IL6, IL1B, IL10, TNF, SOCS1, SOCS3, ICAM1, PTEN, RHOA, GDI2, SUMO1, CASP1, IRAK3, HSPA5, ADRB2, PRF1, GZMB, OASL, CCL5, HSP90AA1, HSPD1, IFNG, MAPK1, RAB5A, and TNFRSF1A had the highest rates of information transfer in 9 candidate modules and central roles in COVID-19 immunopathogenesis.</p>Conclusion<p>This study provides comprehensive information on molecular mechanisms of SARS-CoV-2-host interactions and identifies several hub-high traffic genes as promising therapeutic targets for the COVID-19 pandemic.</p>
Best practices for calibration of forest landscape models using fine-scaled reference information

Field: Environmental Science (Physical Sciences)

Forest Landscape Models (FLMs) project responses to different climate, disturbance, and management scenarios and can inform decision-making that shapes ecosystems. However, use of FLM outputs by decision makers can be hampered by a lack of transparency and credibility in the calibration of modeled processes. Landscape modelers typically use fine-scaled (i.e., plot- or stand-level) information to calibrate the growth functions central to FLMs, but methods vary widely and are often poorly documented. We suggest best practices for calibration and assessment of tree growth in FLMs adapted from prior guidelines to increase rigor in ecological models and their application. Our proposed best practices include: (1) evaluating available information, (2) articulating assumptions, (3) accounting for scale, (4) formalizing model assessment stages, (5) grounding parameter ranges within empirical bounds, (6) considering parameter sensitivity, (7) verifying and corroborating output, (8) making iterative improvements, and (9) delivering sufficient documentation. We illustrate our approach across five case studies that involve a diversity of FLM designs centred on the tree-species, age-cohort structure available within the LANscape DIsturbance and Succession (LANDIS-II) modeling framework. We suggest that these best practices are applicable to many FLM platforms and provide the enhanced transparency essential for wider scientific acceptance of FLM projections.
Fatigue Performance of Glass ReinforcedFibre Concrete in Bridge Deck Applications

Field: Engineering (Physical Sciences)

Bridge decks are critical components of infrastructure, requiring materials with excellent fatigue performance to ensure long-term durability and safety. Glass Reinforced Fibre Concrete (GFRC) offers potential benefits due to its enhanced mechanical properties. This research paper investigates the fatigue performance of GFRC in bridge deck applications, evaluating its behavior under cyclic loading conditions and comparing it with conventional concrete. The study involves experimental testing and analysis to assess the fatigue life, crack development, and overall performance of GFRC. The findings provide insights into the suitability of GFRC for bridge decks, offering recommendations for its application in civil engineering.
Chromatographic methods for isolation and characterization of bioactive molecules from medicinal plant Mesua ferrea Linn

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Partially purified fraction of methanol extract of leaf of Mesua ferrea Linn was assessed for its phytochemical screening. Thin layer chromatographic studies, antimicrobial activity, anti-inflammatory activity, antidiabetic activity and antioxidant activity experiments were conducted. Phytochemical screening reflects the presence of alkaloids, flavonoids, coumarins, terpenoids, steroids, emodins and quinone derivatives. Thin layer chromatographic study was carried out using solvent system of various polarities of n-butanol, acetic acid and acetone. TLC profiling shows pure band of peptide at 254 and 366 nm. Protein content was determined using Nanodrop technique. Antimicrobial efficiency was determined using well diffusion method. Partially purified fractions of Mesua ferrea Linn was most sensitive against Staphylococcus aureus, Pseudomonas aeruginosa and Protease mirabilis with maximum zone of inhibition in diameter 16, 21 and 17 mm respectively at a concentration of 20 µg. In vitro anti-inflammatory activity was evaluated using albumin denaturation (84.67%) membrane stabilization assay (73.6%) and proteinase inhibitory activity (90.62%). Aspirin was used as standard drug for the study of anti-inflammatory activity. In vitro antidiabetic activity was determined by α-amylase inhibition assay. Antioxidant activity was performed by reducing power assay. Fraction #3 has higher absorbance 0.94 at 500 µg/ml followed by fraction #2 absorbance 0.89 at 500 µg/ml.
Quantitative Determination of Alkanes in Cigarette Smoke

Field: Chemistry (Physical Sciences)

The individual alkanes of cigarette smoke are quantitatively determined in a relatively short time through the use of gas chromatography, column chromatography and isotope dilution techniques. The presence of both branched and normal isomers from C<inf>12</inf> through C<inf>33</inf> are indicated. Gas chromatographic conditions for the separation of these components within fourteen minutes are reported and the concentration of individual alkanes from a variety of cigarettes are presented.
Australian Trade Liberalisation Policy: The Industries Assistance Commission and the Productivity Commission

Field: Economics, Econometrics and Finance (Social Sciences)

Abstract The Productivity Commission is Australia’s foremost policy advisory body. Its original incarnation as the Industries Assistance Commission derives from the 1960s push to dismantle the protective tariff regime that underpinned the Australian manufacturing sector. With success in tariff reductions and complementary reductions in rural sector assistance, the Commission’s investigatory role was gradually expanded to cover the entire gamut of government policy. The Commission’s history has generally been treated favourably. This article places the history of the original Industries Assistance Commission in context and takes a critical stance on its and the Productivity Commission’s vision and achievements.
Preoperative Femoral Cartilage T2 Relaxation Time Predicts Change in PROs in Patients with Degenerative Meniscal Tears

Field: Medicine (Health Sciences)

Meniscectomies are common but not always successful in treating degenerative meniscus tears. Preoperative patient reported outcomes (PROs) and quantitative MRI could help surgeons decide candidacy for meniscectomy. This study demonstrated that pre-operative T2 relaxation times in the medial central femoral cartilage are correlated to pre-operative PROs in patients with degenerative meniscal tears and are predictive of 1 and 2-year changes in PROs post-operation. This study suggests patients who have longer T2 relaxation times pre-operation might not benefit as much from a meniscectomy.
PERFORMANCE CHARACTERISTICS OF THE ECONOMIC COMMISSION OF EUROPE (ECE) 9-MONTH-OLD-CHILD TEST DUMMY

Field: Engineering (Physical Sciences)

The calibration procedures specified for the Part 572 3-year-old-child test dummy were used to establish the performance characteristics of the ECE 9-month-old-child test dummy. In addition, head drop tests and sled impact tests utilizing child restraint systems were conducted. The Part 572 calibration requirement are listed for comparison with the ECE dummy response data. Assembly and adjustment problem areas of the ECE dummy were noted.