jimnoneill/paper-to-field-training huggingface dataset:
Surgical outcomes in patients with non-small cell lung cancer receiving neoadjuvant chemoimmunotherapy versus chemotherapy alone: A systematic review and meta-analysis.

Field: Medicine (Health Sciences)

8020 Background: Neoadjuvant immune checkpoint blockade (ICB) including programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) blockade in combination with chemotherapy has been shown to improve survival outcomes in patients with early-stage non-small cell lung cancer (NSCLC). However, its impact on surgery has not been fully elucidated yet. We aimed to compare surgical outcomes between neoadjuvant chemoimmunotherapy with PD-1/PD-L1 blockade and chemotherapy alone in patients with resectable NSCLC. Methods: We performed a systematic search of PubMed and Embase for randomized-controlled trials (RCTs) that compared neoadjuvant chemoimmunotherapy to chemotherapy alone in patients with resectable NSCLC and reported surgical outcomes including surgical resection rates, R0 resection rates, postoperative complications, any-grade treatment-related adverse events (TRAEs), grade 3-5 TRAEs, serious AEs (SAEs), and AEs leading to cancellation of surgery. Meta-analysis was performed using the random-effects model to pool odds ratios (ORs) of these surgical and safety outcomes. Heterogeneity among the included studies for each outcome was assessed using I 2 statistics and high heterogeneity was defined as I 2 higher than 50%. Results: A systematic review identified 5 RCTs with 2,069 patients for a meta-analysis. All identified RCTs evaluated combination of neoadjuvant PD-1/ PD-L1 blockade with chemotherapy versus chemotherapy alone. Chemoimmunotherapy was associated with an improvement in R0 resection rates (OR 1.72, 95% CI 1.22 - 2.42; p = 0.002), whereas surgical resection rates were comparable between two groups (OR 1.51, 95% CI 0.90 - 2.51; p = 0.12). No significant difference was observed for complication rates, any-grade TRAEs, grade 3-5 TRAEs, SAEs, or AEs leading to cancellation of surgery. (Table). Conclusions: Although the surgical resection rate itself was not significantly different between neoadjuvant chemoimmunotherapy and chemotherapy alone, neoadjuvant chemoimmunotherapy was associated with increased R0 resection rates without an increase in the incidence of complications, TRAEs, and cancellation of surgery. This indicates that neoadjuvant chemoimmunotherapy can be safely administered with an increase in R0 resection rate, which potentially leads to improvement of survival outcomes in patients with resectable NSCLC. [Table: see text]
INTERmittent FASTing in people with insulin‐treated type 2 diabetes mellitus – the INTERFAST‐2 study protocol

Field: Medicine (Health Sciences)

Abstract Aim Intermittent fasting, a dietary intervention of alternate eating and fasting, has gained popularity in people trying to lose weight. Intermittent fasting could provide an alternative to classic caloric restriction in people with type 2 diabetes mellitus. The aim of the study is to determine the impact of a 12‐week intermittent fasting regimen compared with usual care in people with type 2 diabetes mellitus receiving insulin therapy. Methods This open, single‐centre, randomized controlled trial investigates participants with type 2 diabetes mellitus on insulin therapy and a glycated haemoglobin A1c (HbA1c) of ≥53 mmol/mol (≥7.0%) and a minimum insulin dose of 0.3 IU/kg body weight per day. Participants are randomized in a 1:1 ratio to either 12 weeks of intermittent fasting or the standard care group. All participants receive dietary counselling, continuous glucose monitoring, measurement of the resting metabolic rate, an oral glucose tolerance test, body composition measurement via dual‐energy X‐ray absorptiometry and stool samples for microbiome analyses at the beginning and at the end of the intervention. Two co‐primary outcomes (analysed in hierarchical order) were chosen for the study: (i) the difference in the change of HbA1c from baseline to 12 weeks and (ii) the difference in the number of participants achieving a combined end point encompassing a body weight reduction of at least 2%, an insulin dose reduction of at least 10% and an absolute HbA1c reduction of at least 3 mmol/mol (0.3%) between the two groups.
Profitabilitas (ROA) Dipengaruhi Oleh Manajemen Kas

Field: Business, Management and Accounting (Social Sciences)

The Purpose of this research is to find out the description of Profitability (ROA) that is influenced by cash management. This type of research used are descriptive, verifikatif. The sampling technique used documentation study. Data analysis technique used is simple linear regresion with computer software SPSS 21.0. Based on the results of the research that cash management influence on profitability. The differences in this study located on an object research , time research, literature that used , the theory that is used and the results of the study
Examination of riverine macro invertebrate riffle assemblages with particular reference to impact of tea plantations

Field: Agricultural and Biological Sciences (Life Sciences)

Freshwater habitats are under threat globally due to human impacts and are relatively little studied in tropical areas. Therefore studies of biodiversity and the effects of human activities are important. In the present study we examined the macro invertebrate diversity in rivers of the East Usambara Mountains, Tanzania. We then focused on the effects of tea plantations as a form of land use in the catchment of our system. We also found that diversity was lower in the Usambara Mountains compared to the reference tropical site in Brazil. Our most salient finding was that tea had a significant effect on river macro invertebrate biodiversity.
The Media Plays On

Field: Social Sciences (Social Sciences)

The COVID-19 pandemic challenged people across the globe and forced change across every industry. Many people were home due to quarantine requirements and to help pass this time turned to media of many forms for their entertainment and social interactions. At a time where new content could not be professionally created due to safety requirements, the entertainment industry was forced to visit their archives and collaborate with specialists to solve this emerging concern. This chapter focuses on the virtual communities developed by the archivists at Iron Mountain Media and Archive Services to implement strategies to service this need through the digitization of legacy media and other assets that they manage for their customers. Through creativity and innovation, these professionals created 21st century solutions through virtual communities to challenges related to training, transportation, digitization, and developed a plan to provide social and emotional support to the masses through the ability to connect with newly available media streaming demands.
Pathologies associated with impacted maxillary canine tooth in patients presenting at a tertiary care hospital

Field: Dentistry (Health Sciences)

Background: The pathologies associated with impacted maxillary canine tooth presented as radiolucent, radiopaque and mixed radiolucent radiopaque lesions on radiographs and adenomatoid odontogenic tumor was the most common pathology associated with it followed by dentigerous cyst, odontoma and calcifying odontogenic cyst after histopathological confirmation. This study was planned to determine the frequency of pathologies associated with impacted maxillary canine tooth in patients presenting at a tertiary care hospital.Methods: This cross-sectional survey was conducted at Dental / Oral Surgery Department, Shaikh Zayed Medical College / Hospital, Rahim Yar Khan, Pakistan from January to December 2017. A total of 60 patients with clinical and radiographic diagnosis of impacted maxillary canine tooth were enrolled. Orthopantomogram and/or para nasal sinus view were considered as the standard radiograph for assessment of pathologies associated with impacted maxillary canine tooth which were confirmed by histopathological examination. Demographics and radiographic findings and histopathological confirmation of pathologies were noted.Results: Out of a total of 60 patients, 38 (63.33%) pathologies associated with impacted maxillary canine presented as radiolucent lesion, 11 (18.33%) each presented as radiopaque and mixed radiolucent radiopaque lesion. Adenomatoid odontogenic tumor (30%) was the most common pathology associated with impacted maxillary canine tooth. The other pathologies associated were dentigerous cyst (26.67%), odontoma (18.33%), calcifying odontogenic cyst (11.66%), calcifying odontogenic cyst with an odonotoma (6.66%), Odontogenic keratocyst (3.33%) and Ameloblastoma (3.33%).Conclusions: The most common pathology occurring predominantly with impacted maxillary canine tooth was adenomatoid odontogenic tumor followed by dentigerous cyst, odontoma and calcifying odontogenic cyst.
Elevated Choline Kinase α–Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Specific deletion of the tumor suppressor TRAF3 from B lymphocytes in mice leads to the prolonged survival of mature B cells and expanded B cell compartments in secondary lymphoid organs. In the current study, we investigated the metabolic basis of TRAF3-mediated regulation of B cell survival by employing metabolomic, lipidomic, and transcriptomic analyses. We compared the polar metabolites, lipids, and metabolic enzymes of resting splenic B cells purified from young adult B cell–specific Traf3−/− and littermate control mice. We found that multiple metabolites, lipids, and enzymes regulated by TRAF3 in B cells are clustered in the choline metabolic pathway. Using stable isotope labeling, we demonstrated that phosphocholine and phosphatidylcholine biosynthesis was markedly elevated in Traf3−/− mouse B cells and decreased in TRAF3-reconstituted human multiple myeloma cells. Furthermore, pharmacological inhibition of choline kinase α, an enzyme that catalyzes phosphocholine synthesis and was strikingly increased in Traf3−/− B cells, substantially reversed the survival phenotype of Traf3−/− B cells both in vitro and in vivo. Taken together, our results indicate that enhanced phosphocholine and phosphatidylcholine synthesis supports the prolonged survival of Traf3−/− B lymphocytes. Our findings suggest that TRAF3-regulated choline metabolism has diagnostic and therapeutic value for B cell malignancies with TRAF3 deletions or relevant mutations.
[Circumflex coronary artery fistula during staphylococcal aortic valve endocarditis].

Field: Medicine (Health Sciences)

We presented a very rare case of the fistula to coronary artery during staphylococcal aortic valve endocarditis in a young man. The tranesophageal echocardiography detected vegetation on aortic valve leaflets and large regurgitatin. During transesophageal echocardiography the peri-anular multi-chamber abscess formation and fistulous communication to circumflex coronary artery was detected.
Large Eddy Simulation of Pulsed Film Cooling with a Dielectric Barrier Discharge Plasma Actuator

Field: Engineering (Physical Sciences)

The effects of the coolant pulsation and the plasma aerodynamic actuation (PAA) on the film cooling are herein explored via large eddy simulations. The electrohydrodynamic force derived from the PAA was solved through the phenomenological plasma model. The Strouhal number of the sinusoidal coolant pulsation and the averaged pulsation blowing ratio were 0.25 and 1.0, respectively. Comprehensive analyses were carried out on the time-averaged flow fields, and the results reveal that the pulsed cooling jet might cause a deeper penetration into the crossflow, and this phenomenon could be remarkably mitigated by the downward force of the PAA. Comparing steady film cooling to pulsed film cooling revealed a modest 15.1% reduction in efficiency, while the application of the dielectric barrier discharge plasma actuator (DBDPA) substantially enhanced the pulsed film cooling efficiency by 42.1%. Moreover, the counter-rotating vortex pair (CRVP) was enlarged and lifted off from the wall more poorly due to the coolant pulsation, and the PAA weakened the detrimental lift-off effect and entrainment of the CRVP. Then, the spatial–temporal development of the coherent structures was figured out by the alterations in the centerline temperature, reflecting the formation of the intermittent coherent structures rather than hairpin vortices due to the coolant pulsation, and their size and upcast behaviors were reduced by the PAA; thus, the turbulent integration of the coolant with the crossflow was suppressed fundamentally. Finally, the three-dimensional streamlines confirmed that the coherent structure dynamic behaviors were significantly regulated by the PAA for alleviating the adverse influences of the coolant pulsation. In summary, the PAA can effectively improve the pulsed film cooling efficiency by controlling the spatial–temporal development of the dominant coherent structures.
МІЖНАРОДНИЙ ДОСВІД ЗАБЕЗПЕЧЕННЯ ДОТРИМАННЯ ДИСЦИПЛІНИ І ЗАКОННОСТІ В ОРГАНАХ ПРАВОПОРЯДКУ

Field: Social Sciences (Social Sciences)

Проаналізовано міжнародний досвід функціонування органів та інституцій, що забезпечують дотримання дисципліни і законності в органах правопорядку, порівняно відповідні структури із функціонуванням інспекцій з особового складу департаменту кадрового забезпечення Національної поліції України та запропоновано шляхи оптимізації їх роботи. Від належного функціонування правоохоронних органів, насамперед, залежить рівень прав і свобод людини і громадянина в кожній державі, де вони існують. Міжнародний досвід відповідних процесів характеризується різними особливостями, що визначають сутність та значення дисципліни та законності у діяльності правоохоронних органів.
Proteomic comparison of four maize inbred lines with different levels of resistance to Curvularia lunata (Wakker) Boed infection

Field: Agricultural and Biological Sciences (Life Sciences)

Protein profiles of leaves in four maize inbred lines with different disease resistance to pathogen Curvularia lunata (Wakker) Boed were studied by two-dimensional electrophoresis (2-DE) and mass spectrometry. Proteins were extracted from the fourth leaf of maize seedlings 24 h after fungal inoculation, and fractionated by polyethylene glycol to precipitate the most abundant leaf protein, Rubisco, before gel separation. Protein profiles from 2-DE showed that total numbers of protein spots were increased in all four inbred lines inoculated with C. lunata CX-3 strain compared with the control. The numbers of changed protein spots in abundance were higher in resistant inbred lines than in susceptible ones, which implied that resistant inbred lines were more sensitive than susceptible ones to pathogen infection. Among proteins identified by MALDI-TOF MS, germin-like protein GLP and translation initiation factor eIF-5A were supposed to play important roles in maize resistance against C. lunata infection.
Reasons for Insulin Omission—What Matters Most?

Field: Medicine (Health Sciences)

Background: One in 3 people with diabetes (88% with type 2 diabetes [T2D]) do not take insulin as recommended an average ∼3.3 days per month. Insulin omission (IO) is associated with suboptimal A1c. Reasons for IO are multifactorial (e.g., cost, fear, stigma). Unclear are what matters most for reducing IO and improving A1c. Objective: We assessed 10 reasons for IO among a national sample of people with T2D, and identified reasons that, if addressed, might improve A1c. Methods: Adults (age 18-75 years) with T2D self-selected to be in a randomized control trial comparing inhalable, ultra-rapid-acting insulin (Afrezza) with One Drop’s digital therapeutics solution vs. injectable, rapid-acting insulin with One Drop. A HIPAA protected, online survey screened potential participants. Eligible persons completed a baseline survey and NGSP certified A1c test. Survey items collected demographics, reasons for IO, and responses to the ARMS-D and SDSCA-IS to assess IO. We used SPSS v25 for psychometric, descriptive, and multivariate statistics, and PROCESS v3 for unadjusted and adjusted mediation models with bootstrapped (10K) CIs. Results: Participants (N=269) were 50±11 years old, 51% male, 30% non-white, 90% insured, with 13±8 years since a T2D diagnosis, and A1c 8.8%±1.8%. ARMS-D insulin had internal consistency reliability (α=.82), and convergent validity with SDSCA-IS (rho=.46, p&lt;.001). IO was associated with higher A1c (β=.39, p&lt;.001). Cost (coef.=.08; 95% CI:.02-.15), disruption (coef.=.07; 95% CI:.001-.15), fear of side effects (coef.=.15; 95% CI:.07-.26), and burnout (coef.=.11; 95% CI:.05-.19) had indirect effects on higher A1c through IO. Reasons were not directly related to A1c. Discussion: Cost, disruption, fear, and burnout were associated with IO, and higher A1c through IO. Given time and resources constraints, clinic visits and self-care interventions must prioritize and address modifiable factors contributing to both non-adherence and higher A1c. Such efforts may be more effective than other approaches. Disclosure C.Y. Osborn: Employee; Self; One Drop. Research Support; Self; MannKind Corporation. Stock/Shareholder; Self; One Drop. L.E. Sears: Employee; Self; Informed Data Systems Inc.. Research Support; Self; MannKind Corporation. A. Hirsch: Employee; Self; One Drop. Research Support; Self; MannKind Corporation. J. Raymond: None. M. Heyman: Employee; Self; One Drop. R. Head: None. J. Dachis: Stock/Shareholder; Self; One Drop. Board Member; Self; One Drop. Employee; Self; One Drop.
Optimal Deployment and Offset Control for a Spinning Flexible Tethered Formation

Field: Engineering (Physical Sciences)

*Recent interest in large space aperture sensing, and spacecraft formation flying in general, has spawned interest in utilizing tethers to connect multiple spacecraft in formation. Tethers provide a viable alternative for keeping spacecraft in formation, as opposed to the necessity of using thrusters for stationkeeping. This paper presents a dynamical model of a flexible tethered formation in Earth orbit. The model accounts for the orbital motion, tether elasticity, damping, and gravity-gradient effects. A simple control model is also used to generate trajectories for the system using an appropriate tension control scheme. The simple model treats the tethers as inelastic and straight. The full dynamics of a spinning tethered formation are numerically simulated using a lumped parameter representation of the system. The model utilizes an object-oriented approach for modeling the multiple tethers used to connect the satellites. For simplicity, only closed triangular formations are considered. The effects of lateral tether vibrations, particular during changes in the tether length, are studied. An offset control strategy is proposed to damp the lateral traveling waves.
Navigating change into the new millennium: themes and issues for the learning organization

Field: Business, Management and Accounting (Social Sciences)

Suggests that the end of the twentieth century may witness the end of modernity and that the post‐modern world of organizations will be driven by a new set of expectations. On the one hand certain trends are discernible as a result of globalization and on the other internal debates within Organizational Development will reshape intervention strategies through organizational learning and Human Resource Development.
Early postoperative angiographic control of the warren procedure in 40 patients

Field: Medicine (Health Sciences)

Abstract Between December 1975 and December 1980, a total of 43 patients with portal hypertension due to intrahepatic block underwent the Warren procedure for distal splenorenal anastomosis. Forty of them were submitted to celiomesenteric arteriography between the 10th and 90th postoperative days to assess the efficacy of the procedure and to estimate its effects on the portal flow to the liver. On the late venous phase of the celiac angiogram, the patency of the shunt was demonstrated in 37 patients (92.5%), along with a consistent reduction of splenic volume; there was a clear flattening of esophageal varices at esophagoscopy. The shunt was not patent in the other 3 patients (7.5%), all of whom had anatomic venous abnormalities (diameter of the splenic vein smaller than 10 mm and/or abnormal renal vein). Two of these patients rebled soon after the operation, while the third subject underwent a prophylactic renoportal shunt . The effects of the procedure on the mesentericoportal flow were studied on the late phase of the superior mesenteric arteriogram. Venous flow to the liver was unaltered in 28 patients, substantially reduced by a latent partial portal thrombosis in 10 (25%), and totally suppressed in 2. Of these 2 complete portal thromboses, one resulted in early recurrent bleeding, while the other has remained asymptomatic. In spite of the portogastric disconnection, reverse flow in large veins from the portal vein to the cardial varices was observed in 14 patients (35%). Thus, after the Warren procedure, esophageal varices are efficiently decompressed by a patent shunt but portal flow is not always preserved .
Turkish standardization of early childhood creativity scale

Field: Psychology (Social Sciences)

The aim of this study was to obtain a culturally adapted Turkish version of the Early Childhood Creativity Scale (ECCS), to test its validity and realibility and to establish the norms for Turkish culture. The study adopted survey design. Research sample included randomly selected 60-83 month old children from 12 different provinces that were determined based on NUTS 1 classification (Antalya, Balıkesir, Bursa, Erzurum, İstanbul, İzmir, Kastamonu, Kayseri, Konya, Malatya, Trabzon and Şanlıurfa). The sample size was calculated using the sampling formula based on the population of the study universe and 1750 children were sampled. Personal information form was used to obtain demographic information about children, and their level of creativity was measured with ECCS, which will be standardized in Turkey. SPSS 20 and LISREL (ver.8.80) were used for the analysis of the data. The analyses verified that ECCS is a valid and reliable tool, with established norms, to use with Turkish children.
Pursuing Practice Mindfulness and Wisdom

Field: Health Professions (Health Sciences)

The sub title of this book, "The search for mindful dialogues" forms the focus of this chapter. The main title, "Community-based healthcare", gives the context through which we have examined the concept and practice reality of mindful dialogues. In this chapter we are linking the research Diane conducted on mindful dialogues with other research Joy has been leading for some time with Diane and several others, about practice wisdom. (Block quotes in italics below, are derived from the latter research program to add to the many quotes in the book from Diane's mindfulness thesis.)