jimnoneill/paper-to-field-training huggingface dataset:
Continuous low‐dose dexamethasone in relapsed or refractory multiple myeloma

Field: Medicine (Health Sciences)

We read with interest two recent papers on the treatment of refractory myeloma (Kneller et al, 2000;Parameswaran et al, 2000). These papers were describing the use of new therapies in this aggressive disease and showed that response can be achieved in these high-risk patients with thalidomide or with CIDEX [CCNU (lomustine), idarubicin, dexamethasone] chemotherapy. Overall, median survival for all patients was 15 months with CIDEX and 24 months in patients classed as responders. Some toxicity was reported with this regimen, the main problem being neutropenia. The thalidomide paper did not report overall survival, but this has been reported elsewhere (Singhal et al, 1999) as 58·5% of patients alive at 1 year. Thalidomide induced some response in 11 of the 17 patients treated and was generally well tolerated with dose-related side-effects. We have previously (Tiplady & Summerfield, 1997) looked at a small group of patients with very similar demographics to these studies, have assessed their response to continuous low-dose dexamethasone and would now like to report the longer term follow-up of these patients. Dexamethasone is well established in the treatment of myeloma and is part of many, usually pulsed, regimes. We selected 15 patients (seven men, eight women) who had failed at least primary treatment, six of whom had failed two or more standard therapies. Ages ranged from 54 to 84 years (median 67 years) and the median time from diagnosis was 43 months (range 7–67 months). Treatment was straightforward, beginning at 4 mg/d of dexamethasone and reducing this over 3–6 months to 0·5 mg on alternate days, depending on the response. A fall in paraprotein levels of greater than 50% was observed in six of the 15 patients; seven of the 15 had static disease and the remaining two showed disease progression. Survival of all patients, not just responders, from the time continuous dexamethasone was started showed a median of 20 months and is shown in Fig 1. Toxicity was rare. There were no episodes of treatment-related neutropenia or gastrointestinal side-effects and deaths were due to eventual disease progression. Overall survival in all patients (n = 15) from commencement of continuous low-dose dexamethasone (CLD). Median survival = 20 months. Median time from diagnosis of myeloma to start of CLD = 43 months. In summary, we have shown similar results to CIDEX and thalidomide in small numbers of non-randomized patients with myeloma and feel that continuous low-dose dexamethasone, as an easily given and well-tolerated drug, may be worthy of further investigation in conjunction with these other therapies.
Herders And Farmers Conflict And Its Implication For The 2019 General Elections In Nigeria: What Can Public Relations Do?

Field: Social Sciences (Social Sciences)

The paper analysed the herders and farmers' conflict and its implications on the forthcoming 2019 General Elections in Nigeria with focus on what public relations can do.The paper was anchored on the Dialectical Materialism Theory and supported by the Frustration Aggression Theory and Frank Jefkins Public Relations Transfer Process Model.The paper adopted survey research method to elicit data using interview as research instrument.Findings revealed that interethnic and intergroup conflicts have been on the increase since the evolution of democratic rule in 1999, and that the stakeholders meetings convened by the Federal Government of Nigeria are not all-inclusive but elitist.The paper recommended amongst others that the Federal Government should do more in curtailing the killings, destruction of properties and farmlands associated with the conflict and apply public relations strategies such such as dialogue, truth and full information, that the herders should establish ranches in order to curtain incessant conflict between them and farmers in line with best international livestock practice.
A Cause Analysis of Low Fertility and Population Aging in Korea: Evidence from Economic Factors in Marriage Determination

Field: Economics, Econometrics and Finance (Social Sciences)

The purpose of this paper is to investigate whether the decline in the number of marriages and the rise in the age of first marriage in Korea have been influenced by economic factors through the analyses of city and province penal; and labor and income panel data. To this end, we carry out empirical analyses, mainly focusing on the effects of employment instability and housing costs on marriage. The results of empirical analysis are summarized as follows: First, sharply growing instability in employment since the Korean currency crisis has led to a drop in marriage cases and a rise in the age of first marriage. Notably, a rise in the age at first marriage of males resulting from aggravating employment instability also pushes up the age of females at first marriage. Second, a hike in housing prices results in the increase in marriage costs, rendering more difficulty to males when they try to join the marriage market.
Clinical Features, Disability and Socioeconomic Status of Patients With Muscular Dystrophy in Korea

Field: Medicine (Health Sciences)

rare and intractable disease, and has ensured that patients with this condition obtain support from the National Health Insurance Corporation for their medical expenditure. However, the health-related and socioeconomic status of Korean patients with MD has yet to be established. Methods: We selected 441 patients with MD who received medical services at 17 neuromuscular centers during 2005.
ZACHARY LESSER, Renaissance Drama and the Politics of Publication: Readings in the English Book Trade. Pp. xii + 244. Cambridge, New York, Oakleigh: Cambridge University Press, 2004. 45.00 (ISBN 0 521 84252 2).

Field: Arts and Humanities (Social Sciences)

IN the days when Formalism, such as that found in the New Criticism, reigned supreme, textual and bibliographical scholars were interested only in the texts of works and the immediate producers of those texts, the printers. Those Fellow Travellers of the New Critics, the New Bibliographers (Greg, McKerrow, Fredson Bowers, Charlton Hinman, and others), devoted their very considerable energies to discovering what happened to the authors’ manuscripts once they reached the printing house and how far these manuscripts were removed from the authors’ original drafts. They were somewhat less concerned with the agents and agencies who got those manuscripts, of whatever kind, from the authors to the printers, by whatever means. However, in the last twenty-five years there has arisen a new school of bibliotextual study, sometimes called the Sociology of Texts and sometimes the History of the Book, which has been very concerned with all those factors which come...
Epilepsy, marriage, and other social relationships

Field: Medicine (Health Sciences)

Abstract Aside from the physiological disease, the psychosocial ramifications of the epilepsy greatly affect a person’s social relationships and, in turn, their quality of life. The social perception of epilepsy is shaped through a long history of stigma and discrimination, dating back millennia. Even in the 21st century, epilepsy can remain a very stigmatizing condition around the world. Stigma can influence nearly every component of a person’s life, from their education and workplace to marriage and childbearing. In addition to testing the resilience of those with the condition, epilepsy can apply additional pressure on parents, siblings, carers, and life partners. This chapter reviews these factors and discusses future directions for research in this field.
Validation of Romantic Partner Conflict Scale (RPCS) in Pakistani Married Couples: Establishing Measurement Invariance

Field: Psychology (Social Sciences)

The present study aimed to translate and validate the Romantic Partner Conflict Scale (RPCS) in Pakistani Married Couples. Forward-Backward Method was applied for translations into Urdu to establish conceptual equivalence and cultural relevance. A sample of 300 married couples was collected for construct validation of RPCS established through Confirmatory Factor Analysis with SEM with the confirmed factors of Compromise, Domination, Submission, Separation, Avoidance, and Interactional Reactivity (total of 37 items, 2 items were deleted). All subscales showed good internal consistency and composite reliabilities. Moreover, testing for measurement invariances across husbands and wives further confirmed the factor structure for dimensions of RPCS. Finally, further associations revealed that constructive conflict strategies of Compromise and Avoidance were positively associated with positive relational variables such as internal marital locus of control, constructive communication, marital quality, and intimacy, but were negatively correlated with demand-withdraw patterns, associations for destructive conflict strategies of Interactional Reactivity and Domination with these relational variables were revealed contrary to the constructive strategies. The present study revealed Separation and Submission as mixed strategies as they were positively associated with majority of positive and negative relational variables. Additional findings in case of demographic variables and implications for future research are discussed.
A New “Thumb” Urethroplasty

Field: Medicine (Health Sciences)

No AccessJournal of Urology1 Aug 1971A New “Thumb” Urethroplasty Stephen V. Kishev Stephen V. KishevStephen V. Kishev More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)61265-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1971 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByIslam M (2018) Posterior Urethral Trauma and Strictures: An Attempt to Solve a ControversyJournal of Urology, VOL. 119, NO. 3, (418-421), Online publication date: 1-Mar-1978.Kishev S (2018) Excision of the Urogenital Diaphragm: A Method of Repair of the Completely Obstructed Membranous UrethraJournal of Urology, VOL. 115, NO. 5, (548-550), Online publication date: 1-May-1976. (2018) CommentJournal of Urology, VOL. 115, NO. 5, (550-550), Online publication date: 1-May-1976.Kishev S (2018) Closure Of Fistula At The Penoscrotal Junction Of The UrethraJournal of Urology, VOL. 111, NO. 6, (774-777), Online publication date: 1-Jun-1974. Volume 106Issue 2August 1971Page: 231-235 Advertisement Copyright & Permissions© 1971 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Stephen V. Kishev More articles by this author Expand All Advertisement PDF DownloadLoading ...
Formulation and Evaluation of Facial Wash Gel Preparation from Celery Leaf Ethanol Extract (Apium graveolens L.) Against Staphylococcus aureus Bacteria

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Facial wash is a facial cleansing soap that can clean oil and cosmetics that stick to the face. Usually facial wash has a low pH or close to the skin's normal pH, namely 4.5-6.5 and contains milder detergent. Researchers are to determine which celery leaf extract (Apium graveolens L.) is being evaluated as a facial wash preparation and to determine which facial wash preparation has inhibitory power for the growth of Staphylococcus aureus bacteria. This research is experimental using the maceration method. The sample used in this research was 10 kilograms of celery leaves. Results : Testing the pH of the celery leaf ethanol extract facial wash gel preparation for each F0, F1, F2 and F3 showed that the pH of the celery leaf ethanol extract facial wash gel preparation decreased due to the presence of acid compounds in celery leaves, causing the pH to decrease slightly but still within the pH range. topical, namely 4.5-7.0 and the pH of the celery leaf ethanol extract facial wash gel preparation above shows a relatively neutral pH which is still safe for the skin. The facial wash gel preparation of ethanol extract of celery leaves (Apium graveolens L.) has an inhibitory zone containing Staphylococcus aureus bacteria in K(+), K(-), F1 (5%), F2 (10%) and F3 (15%) with strong inhibition zone category. Researchers found that the ethanol extract of celery leaves can be formulated in the form of a facial wash gel. It is recommended that further research be carried out on the effectiveness of celery leaves with different concentrations and methods.
The Natural History of Atopic Dermatitis

Field: Medicine (Health Sciences)

The case records of 492 consecutive patients with atopic dermatitis seen at the Mayo Clinic between 1940 and 1942 were reviewed, and follow-up questionnaires were sent 20 years later. Forty-five per cent of the patients responded. We made the following observations: A family history of atopy was found in 66% of all patients presenting with atopic dermatitis. Prognosis concerning the severity of the disease, however, cannot be based on the family history. Approximately 13% of the patients having atopic dermatitis may be expected to have associated pneumonia during the course of their disease. Determination of eosinophil count in the blood is not a useful tool in predicting the severity or course of atopic dermatitis. Atopic cataracts occurred in 4% of the mild group and in 13% of the severe group. Atopic eczema was generally first noted at the age of 4 months. Only 40% of the patients with mild atopic dermatitis and only 29% of those with severe disease stated after 20 years that their dermatitis had cleared. In 11 % of the patients the eczema became localized to the hands. Asthma, hay fever, urticaria, migraine headaches, and rhinitis were found in 55% of patients having atopic dermatitis. The patients considered nervous tension, cold climate, and perspiration as the most significant causative factors. Factors most helpful in relieving atopic dermatitis were relaxation, temperate climate, topical and oral steroids, and avoidance of primary irritants. Only 5% of patients reported benefit from hyposensitization therapy.
Mathematical Modeling for Holistic Convex Optimization of Hybrid Trains

Field: Engineering (Physical Sciences)

We look into modeling fuel cell hybrid trains for the purpose of optimizing their operation using convex optimization. Models and constraints necessary to form a physically feasible yet convex problem are reviewed. This effort is described as holistic due to the broad consideration of train speed, energy management system, and battery thermals. The minimized objective is hydrogen fuel consumption for a given target journey time. A novel battery thermal model is proposed to aid with battery thermal management and thus preserve battery lifetime. All models are derived in the space-domain which along constraint relaxations guarantee a convex optimization problem. First-principle knowledge and real-world data justify the suitableness of the proposed models for the intended optimization problem.
Bir Olgu Nedeniyle Hellp Sendromunun Ayırıcı Tanı Ve Tedavisi

Field: Medicine (Health Sciences)

DIAGNOSIS AND CURRENT MANAGEMENT OF THE HELLP SYNDROME: A CASE REPORT✓The HELP syndrome that is seen in about 10% of patients with severe preeclampsia-eclampsia describes patients with hemolytic anemia, elevated liver enzymes, and low platelet count. This syndrome is frequently misdiagnosed as acute fatty liver of pregrancy, idiopathic thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP), or hemolytic uremic syndrome (HUS). Althought reversal of the laboratory parameters has been reported with some medical regimens, because of high maternal and fetal mortality, most authorities agree that the patients with the HELLP syndrome necessitate aggressive therapy, including delivery.In this article, we presented a case fitting the HELLP syndrome, and reviewed the diagnosis and current management methods for pregrants with the HELP syndrome.Ağır preeklampsi ve eklampsilerin yaklaşık % 10 kadarında görülün HELLP sendromu; hemolitik anemi, yükselmiş serum karaciğer enzim düzeyleri ve düşük trombosit sayısı ile karakterizedir. Bu sendromun tanısı; gebeliğe bağlı akut yağlı karaciğer, idiopatik trombositopenik purpura, trombotik trombositopenik purpura ve hemolitik üremik sendrom ile sıklıkla karışır. Her ne kadar bazı tıbbi uygulamalar ile sendromun bulgularının geriye döndüğü rapor edilmişse de yüksek maternal ve fetal mortalite nedeniyle, çoğu yazarlar HELLP sendromlu hastalarda doğumu da içeren agressif tedavi gerekliliğini belirtmektedirler. Bu makalede, HELLP Sendromu bulgularını içeren bir olgu sunduk ve HELLP sendromlu gebelerde güncel tanı ve tedavi yöntemlerini gözden geçirdik.
Development of Room Air Conditioner with Twin-Propeller Fans

Field: Engineering (Physical Sciences)

In order to realize a significant energy conservation and comfort of room air conditioners, we have developed a new structure indoor unit which drastically reviewed the internal structure for the first time in about half a century. This indoor unit improves energy saving performance by changing the shape of the air passage matching the air flow through the indoor unit from the upper side to the lower side, changing to the fan shape suitable for the air passage, and efficient arrangement of the heat exchanger. We reduced the power consumption of the indoor unit by 31% and improved the APF by 13.3% compared with the previous year. In addition, we realized an improvement in comfort by controlling the airflow making full use of the features of the new fan shape.
Morphological Changeability Of Cones Of Norway Spruce [Picea Abies (L.) Karst.] In The Białowie˝A Forest

Field: Agricultural and Biological Sciences (Life Sciences)

In the frame of research conducted in the year 2003 on masting of spruce in the Białowieża Forest, spruce cones were collected from trees differentiated with regard to their age as well as growing sites located in deciduous and coniferous forest. The collection of cones was conducted in managed forests of the Białowieża Forest District. Before taking out seeds, the cones were divided into 5 sectors: cone base (p), zone over cone base (np), cone central part (s), zone below cone-top (pw) and cone-top (w). This allowed evaluation of the size and shape of scales contained by cones. The results showed that the biggest cones were formed by spruces 60– 80 years old which were growing on deciduous sites. The longest scales were situated in the cone central part, and the widest were found in the zone over cone base. Differentiated size of cones and scales, situated in distinguished cone zones, can influence the speed of scale opening and the sequence of seed releasing. This can be applied in the process of harvesting of high quality seeds – necessary for the production of seedlings with the use of modern nursery technologies.
Globalization, Reterritorialization, and Marketing

Field: Business, Management and Accounting (Social Sciences)

Accelerated globalization has dramatically altered the ways in which people consume, work, gather information, play and define their identity. Most extant discourse on globalization, particularly in the business discipline, ignores the impact of globalization on the identity of those affected. One of the key characteristics of globalization is deterritorialization; the severance of social, political, and cultural practices from their native places. Deterritorialization potentially destabilizes people‘s identity. In response, individuals will undertake activities and behaviors which help them “reterritorialize” and restore their sense of identity. This phenomenon has interesting implications for researchers as well as practitioners.
Kinetic studies of OH reactions with H2O2, C3H8 and CH4 using the pulsed laser photolysis - laser induced fluorescence method

Field: Chemistry (Physical Sciences)

The rate coefficients for the reactions of OH with H2O2, C3H8 and CH4 have been determined using a newly built pulsed laser photolysis-laser induced fluorescence (PLP-LIF) apparatus. While, the reaction of OH with H2O2 was studied at room temperature, the rate coefficients of OH reactions with CH4 and C3H8 were measured over a large range of temperature at P = 100 Torr of helium. The measured rate constant for the reaction of OH with H2O2 was k] = (1.75 ± 0.20) × 10-12 cm3 molecule-1 s-1. The kinetic data for C3H8 (k2) and CH4 (k3) were used to derive the Arrhenius expressions (in cm3 molecule-1 S-1) : k2 = (9.81 ± 0.11) × 10-12 exp[-(650 ± 30)/T] between 233 and 363 K, and k3 = (2.56 ± 0.53) × 10-12 exp[-(1765 ± 146)/T] between 233 and 343 K. The results obtained for k1 and k2 provide a validation of the PLP-LIF technique and those for k3 support the low value recently published, which has an important atmospheric impact.
Advantages,disadvantages and applications of in vitro hepatic metabolic models

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The liver is the predominant organ participating metabolism of xenobiotics.Generally,drugs will be mainly eliminated from the body by the way of metabolism.Drug biotransformation is one of the most important events that affect the overall pharmacologic and toxic profile and the subsequent therapeutic and safety index.Hence,hepatic metabolism research is a key step in the preclinical drug discovery and development process.For this purpose,in vitro approaches using various hepatic metabolism models,with the merits of rapidness,accuracy,high throughput have been gaining increasing popularity in the academic and pharmaceutical fields.The presently used in vitro models includes recombinant enzymes,microsomes,cytosol,S9 fraction,cell lines,transgenic cell lines,primary hepatocytes,stem cell derived hepatic cell,precise liver slices and perfused liver.This review will describe the advantages,disadvantages and the applications of these in vitro models with the purpose of facilitating researchers to choose appropriate models to make reasonable evaluation of in vitro metablism and study the possible drug biotransformation model in liver,and finally to predict drug elimination mode in vivo scientifically.