jimnoneill/paper-to-field-training huggingface dataset:
Cardiotoxicity in Cancer Immunotherapy: Pathological and Future Directions

Field: Medicine (Health Sciences)

Cancer and its complication remain one of the most popular and serious neoplasia disease in the domain of medicine. Although more and more immunotherapies have been developed and put into use, there still exist many unknown issues waiting to be explored in the laboratory and clinical application. Cardiotoxicity is one of the complex side effect of some active immunotherapies and may bring negative treatment issues for patients have heart disease in the past times and those at risk of developing heart disease. This review analyse the pathological manifestations and specific mechanisms of cardiac side effects caused by different tumor immunotherapies are presented, along with existing drug and non drug response measures and patient education. This review find the myocarditis caused by immune inflammation could be the vital relation between immunotherapy and cardiac functions. This study can provide medical direction and patient education reference for future research on the side effects of cancer immunotherapy. However, there is insufficient medical theories of the related effects of the immune system and tumor blood vessels. Future research can focus more on the reaction between some antigen antibody cancer vaccine drugs and the immune system.
Antimicrobial Agent Susceptibility and Typing of Staphylococcal Isolates from Subclinical Mastitis in Ewes

Field: Veterinary (Health Sciences)

Objective was to study susceptibility to antimicrobial agents of 142 staphylococcal isolates from subclinical mastitis in ewes. In total, 41.5% of these were resistant and 5.6% multidrug resistant. More coagulase-negative staphylococci (47.0%) were resistant than Staphylococcus aureus (18.5%) isolates. Resistance was greater to penicillin (22.5%), tetracycline, or ampicillin (18.3%). More biofilm-forming (20.6%) isolates were resistant to tetracycline than nonbiofilm-forming (0.0%) ones. Presence of tetK was associated with presence of icaA in the same strains. Further, 76.6% of resistant isolates versus 57.7% of susceptible ones were recovered immediately postpartum and 23.4% of resistant isolates versus 9.9% of susceptible ones were recovered in farms that practiced routine administration of antimicrobial agents at the end of a lactation period. Most S. aureus (59.3%) were classified in ST133 and most Staphylococcus epidermidis were classified in ST100, ST142, or ST152 (19.0% each). There was no association of sequence types with resistance. Whole genome sequencing showed that, in a Staphylococcus lentus strain, the ermB gene was part of transposon Tn917 integrated into the chromosome; also, a small plasmid was observed in an ermC-carrying Staphylococcus hominis strain and, finally, in an S. aureus and an S. epidermidis strains, small tetK-carrying plasmids (pSau-2716Lar, pSau-3893Lar) of 4.439 kb were found.
The Realization of Maqoshid Shari’ah as Local Values in Industrial Relations Disputes Resolution Efforts

Field: Social Sciences (Social Sciences)

In the era of globalization, the role of Trade Unions is very important.Trade Unions can represent workers in industrial relations dispute resolution and carry out activities to improve workers' welfare.Trade Unions can sometimes take unwise actions that cause suspicion to others.The problem in this research can be solved by planting Maqoshid Sharia in the value of local wisdom as a model in the efforts to resolve the industrial relations disputes among union administrators.The purpose of this study is to provide an overview of the implementation of the value of maqoshid sharia as an alternative solution in the efforts to resolve industrial relations disputes.This research is juridically normative with conceptual and statutory approaches.The results of this study are Maqoshid Sharia which is the goal of Islamic law has two dimensions, namely al wujud and al adam.Consisting of five things, namely laying the foundation of goodness to maintain religion, self, nasab, wealth and reason.Everything has three levels, namely dhoruriyat, hajjiyat and tahsiniyat.These three levels must be implemented by the management of trade unions when facing a conflict of problems based on their priority level as the efforts to resolve industrial relations disputes through litigation or non-litigation.The conclusion was that the trade unions must understand the roots of the disputes object of the industrial relations that occur.Furthermore, it would try to achieve the goodness by conducting a problem analysis based on Maqoshid Sharia to determine the strategical implementation of the three levels of Maqoshid Sharia, namely dhoruriyat, hajjiyat and tahsiniyat)
Image blind deblurring using an adaptive patch prior

Field: Computer Science (Physical Sciences)

Image blind deblurring uses an estimated blur kernel to obtain an optimal restored original image with sharp features from a degraded image with blur and noise artifacts. This method, however, functions on the premise that the kernel is estimated accurately. In this work, we propose an adaptive patch prior for improving the accuracy of kernel estimation. Our proposed prior is based on local patch statistics and can rebuild low-level features, such as edges, corners, and junctions, to guide edge and texture sharpening for blur estimation. Our prior is a nonparametric model, and its adaptive computation relies on internal patch information. Moreover, heuristic filters and external image knowledge are not used in our prior. Our method for the reconstruction of salient step edges in a blurry patch can reduce noise and over-sharpening artifacts. Experiments on two popular datasets and natural images demonstrate that the kernel estimation performance of our method is superior to that of other state-of-the-art methods.
Inhibition in the auditory brainstem enhances signal representation and regulates gain in complex acoustic environments

Field: Neuroscience (Life Sciences)

Inhibition plays a crucial role in neural signal processing, shaping and limiting responses. In the auditory system, inhibition already modulates second order neurons in the cochlear nucleus, e.g. spherical bushy cells (SBCs). While the physiological basis of inhibition and excitation is well described, their functional interaction in signal processing remains elusive. Using a combination of in vivo loose-patch recordings, iontophoretic drug application, and detailed signal analysis in the Mongolian Gerbil, we demonstrate that inhibition is widely co-tuned with excitation, and leads only to minor sharpening of the spectral response properties. Combinations of complex stimuli and neuronal input-output analysis based on spectrotemporal receptive fields revealed inhibition to render the neuronal output temporally sparser and more reproducible than the input. Overall, inhibition plays a central role in improving the temporal response fidelity of SBCs across a wide range of input intensities and thereby provides the basis for high-fidelity signal processing.
Intravenous diazepam administration

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

To the Editor.— One predisposing factor was omitted in the article by Langdon et al (223:184, 1973) describing thrombophlebitis following intravenous injection of diazepam. In the package insert, the manufacturer cautions that injectable diazepam (Valium) should not be mixed or diluted with other solutions or drugs, nor added to intravenous fluids. The manufacturer responded to our inquiry concerning the reason for this restriction, by explaining that injectable diazepam has very low solubility in water and aqueous solutions. For this reason, it was buffered with a formulation including benzoate sodium. Dilution of the solvent system results in precipitation of the diazepam. If the solution is then acidified, a precipitate of benzoic acid will result, which may coprecipitate with the drug. Langdon et al do not describe whether they injected the drug directly into the vein or through a tube. Since, in some of their patients, more than 10 mg was injected, the
On-line expert system for power system diagnosis and restoration

Field: Engineering (Physical Sciences)

We have implemented a real-time expert system as part of a supervisory control and data acquisition system for the Public Utilities Board of Singapore, controlling its 22 kV distribution network. It works as an operator support tool by diagnosing network disturbances and device malfunctions, and by presenting a switching sequence which can be executed immediately to restore supply. In this paper we describe how the expert system is integrated into a large supervisory control and data acquisition system for power distribution networks. The necessary techniques to cover on-line processing of real-time data, intelligent alarm processing and network reconfiguration/restoration are discussed. The expert system is based on a hierarchic multi-level problem-solving architecture, integrating model-based, heuristic and algorithmic techniques acting on an object-oriented data structure. Techniques such as the automatic creation and update of the knowledge base, event filtering, on-line event processing, and structural and temporal focusing have been implemented to enable the system to perform its task on-line and in real time.
Proof of Will of Rhoda E. Kirksey, Tuscaloosa County, Alabama, February 20, 1865

Field: Arts and Humanities (Social Sciences)

This item is from the Robert Jemison, Jr. Papers. The collection spans the period from 1797 to 1960 and includes both the personal and business papers of Robert Jemison, Jr., along with papers of Robert Jemison (grandfather), William Jemison (father), Priscilla Jemison (wife), Cherokee Jemison Hargrove (daughter), and Andrew Coleman Hargrove (son-in-law), and Robert Jemison, Jr. (IV) of Birmingham (1878-1973). Included are the records of his grist and lumber mills, plantations, stage line, the Tuskaloosa Plank Road, toll bridges, ferries, postal contracts, and the North East and South West Railroad.
Criterion assessment of soil transport structure stability

Field: Engineering (Physical Sciences)

This paper considers features in forming stress -strain state (SSS) and stability of soil transport structures (cut and embankment) on the basis of calculation with the certified finite element method (FEM) GenIDE32. Numerical calculations make it possible to see the whole process of modeling organization of a soil structure: places where “plasticity” zones appear and develop, gradual formation of a landslide body. The analysis of SSS uses graphs of changes of SSS trajectories in the space of invariants of stress tensor σ ij and relative deformations ε ij in important nods and finite elements located at the sliding lines. At each step of modeling stability of depression or embankment is evaluated. Many signs indicate the termination of the landslide body formation. Noted in figures and graphs evolution of a landslide prism allows one to understand where the system is from the condition at which the landslide body formed: k stmin =1,00±0,02≈[k st ]=1,00.
Sapphic Stanzas: How Can We Read the Rhythm?

Field: Arts and Humanities (Social Sciences)

This essay asks if, and how, we can read the rhythms of Sappho’s poetry as if it could be heard, still. The Sapphic stanza is a poetic form that has gone through a long history of transformations, from a powerful metrical imaginary in Victorian poetics (graphing Sapphic meter as a musical form) into an idealization of “Sapphic rhythm” in twentieth-century prosody (naturalizing the rhythms of speech). By comparing metrical translations of Sapphic fragment 16 (“The Anactoria Poem,” discovered in 1914), the essay proposes “metametrical” reading as a model for critical reflection on the complex dialectic between rhythm and meter. Examples are drawn from Victorian metrical theory and Anglo-American imitations of Sappho by modern and contemporary poets, including Joyce Kilmer, Marion Mills Miller, Rachel Wetzsteon, John Hollander, Jim Powell, Juliana Spahr, and Anne Carson..
An Overview of the History of HIV/AIDS Transmission and Prevention in China

Field: Social Sciences (Social Sciences)

This article provides a systematic and in-depth overview of the history of HIV/AIDS transmission and prevention in China, including its historical development stages and academic research. From a historical perspective, the article explores the origin and development of HIV/AIDS transmission in China, as well as the government and society's attitudes and prevention measures towards the disease. From an academic perspective, it reviews the research progress in HIV/AIDS prevention and treatment, covering medical, social, political, and cultural aspects. Through these overviews, the article gains a deep understanding of the main content and basic characteristics of HIV/AIDS transmission and prevention in China and also explores the actual situation of research on the history of HIV/AIDS transmission and prevention, providing a reference for HIV/AIDS prevention and control work.
ABCA6 Regulates Chondrogenesis and Inhibits Joint Degeneration via Orchestrated Cholesterol Efflux and Cellular Senescence

Field: Medicine (Health Sciences)

Abstract Patellar dysplasia (PD) can cause patellar dislocation and subsequent osteoarthritis (OA) development. Herein, a novel ABCA6 mutation contributing to a four‐generation family with familiar patellar dysplasia (FPD) is identified. In this study, whole exome sequencing (WES) and genetic linkage analysis across a four‐generation lineage presenting with six cases of FPD are conducted. A disease‐causing mutation in ABCA6 is identified for FPD. Further analyses reveal a consistent correlation between ABCA6 expression downregulation and PD occurrence, chondrocyte degeneration, and OA onset. Moreover, ABCA6‐KO mice demonstrate severe knee joint degeneration and accelerated OA progression. Besides, synovial mesenchymal stem cells (SMSCs) are extracted from WT, ABCA6 −/+ , and ABCA6 −/− mice to create chondrogenic organoids in vitro, confirming ABCA6 deficiency can lead to chondrocyte degeneration via modulating cell cycle and activating cellular senescence. Moreover, transcriptome and metabolomic sequencing analysis on ABCA6‐KO chondrocytes unveils that the ABCA6 deficiency inhibits cholesterol efflux, leading to intracellular cholesterol accumulation and subsequent cellular senescence and impaired chondrogenesis.A disease‐causing mutation of ABCA6 is identified for FPD. ABCA6 is correlated with PD occurrence and subsequent OA progression. ABCA6 can serve as a potential target in chondrogenesis and OA treatment by orchestrated intracellular cholesterol efflux and delayed cellular senescence.
A Sustainability Comparison of Traditional Supply Chains and Physical Internet Supply Chains Using Simulation

Field: Decision Sciences (Social Sciences)

Sustainability is one of the most important topics that should be considered by every sector because it helps to reduce the harmful environmental effects of operations. Supply chain operations have significant impacts on environmental, social and economic issues, and therefore, sustainable supply chains have become an important issue for the companies. Also, Physical Internet (PI) is one of the recent research topics in supply chain literature and it helps to provide sustainability. The contribution of this study to the literature is the comparison of traditional supply chain and Physical Internet supply chain structures with simulation in terms of sustainability. The simulation models are tested on realistic but hypothetical case studies. Each simulation model consists of three echelons (supplier, distribution center and retailer) and is developed by using ARENA 14.0 software. The physical internet and the traditional are compared according to carbon emissions, and the results are discussed in detail.
Improved Medication communication and Patient involvement At Care Transitions (IMPACT-care): study protocol for a pre–post intervention trial in older hospitalised patients

Field: Health Professions (Health Sciences)

Introduction Care transitions, particularly hospital discharge, present significant risks to patient safety. Deficient medication-related discharge communication is a major contributor, posing substantial risk of harm to older patients. This protocol outlines the Improved Medication communication and Patient involvement At Care Transitions (IMPACT-care) intervention study, designed to evaluate the effects of a multifaceted intervention for older hospitalised patients on medication-related discharge communication compared with usual hospital care. Methods and analysis A pre–post intervention study will be conducted in two surgical and one geriatric ward of a university hospital in Sweden. The study will begin with a control period delivering usual care, followed by a training period and then an intervention period. The intervention comprises four components performed by clinical pharmacists: (1) information package provided to patients and/or informal caregivers, (2) preparation of medication-related discharge documentation, (3) facilitation of discharge communication and (4) follow-up call to patients or their informal caregiver. Eligible participants are aged ≥65 years, manage their own medications independently or with informal caregiver support, and are admitted to the study wards. Each study period (control and intervention) will last until 115 patients have been included. The primary outcome is the quality of medication-related discharge documentation, assessed using the Complete Medication Documentation at Discharge Measure (CMDD-M). Secondary outcomes include patients’ perceptions of knowledge and involvement in discharge medication communication, and their sense of security in managing medication post-discharge; adherence to medication changes from hospitalisation that persist after discharge; and unplanned healthcare visits following discharge. A process evaluation is planned to explore how the intervention was implemented. Patient inclusion began in September 2024. Ethics and dissemination The study protocol has been approved by the Swedish Ethical Review Authority (registration no.: 2023-03518-01 and 2024-04079-02). Results will be published in open-access international peer-reviewed journals, and presented at national and international conferences. Trial registration number NCT06610214 .
COMPATIBILITY BETWEEN DATA FROM THE PREGNANT CARD AND THE COMPUTERIZED WEB SYSTEM SISPRENATAL

Field: Health Professions (Health Sciences)

The Brazilian Ministry of Health asserts that the prenatal and puerperal cares are extremely important to a healthy pregnancy and to the wellbeing of the mother and the fetus. In this context, the Pregnant Card and the SisPreNatal register – aninformational system for monitoring the health of both mother and baby – has been deployed in the Brazilian Unified National Health System. Thus, this research aims to verify the compatibility between information from the Pregnant Card and the computerized web system SisPreNatal of pregnant women. We carried out a quantitative research with descriptive design. 150 pregnant women who attend an obstetrical emergency hospital on the east side of São Paulo participated in the study. The researchers analyzed variables related to the pregnant women, the conduction of the mandatory actions of prenatal care, the data related to the service, and the data related to SisPreNatal. The results provedthat there is compatibility between data from both of data sources (Pregnant Card and SisPreNatal system) in only 20% of the cases nalyzed.Therefore, this is a very relevant study since it intends to contribute to the health professionals involved, offering guidelines on the benefits of those data for the medical and nursing service and supporting the idea that the incomplete filling of the register Health, Health Evaluation, Prenatal Care, Pregnant Card, SisPreNatal and the non-compatibility of data interfere on the quality of this service.
Effect of different phosphorus levels on the performance and egg quality of laying hens fed wheat- and maize-based diets

Field: Agricultural and Biological Sciences (Life Sciences)

The effects of diet type (wheat- or maize-based) and concentration of available phosphorus (AP; about 4, 3 and 2 g/kg) on the parameters of hen performance and egg quality as well as shell calcium (Ca) and phosphorus (P) contents were examined. Two experiments were carried out in which 240 and 120, respectively, older ISA Brown hens were housed in enriched cages. The interaction of diet type and AP concentration was ascertained for all evaluated characteristics except the amount of Ca and P deposited in shells in the first experiment. In the second experiment, the interaction of diet type and AP concentration was found for feed intake, egg weight, shell thickness and weight as well as the albumen quality parameters. Furthermore, Ca deposition in shells increased (P < 0.001) with the wheat diet. Hens fed a maize-based diet (P < 0.001) laid heavier eggs. The highest level of AP (4.1 g/kg) in the wheat-based diet significantly (P < 0.001) decreased albumen height, albumen index and Haugh units (HU). These trends were the same in both experiments. The results indicate that 0.27% AP in wheat-based diet and 0.30% AP in maize-based diet are adequate for hens with the intake 115 g of feed with 3.5% of Ca without a negative impact on performance or egg quality.
France and American Literature: The Crocodile Beckons

Field: Arts and Humanities (Social Sciences)

Fyodor Dostoevsky's The Crocodile/' a hapless civil servant named Ivan Matveitch goes to see an Egyptian crocodile on exhibition. It is not every day that such an exoticism comes to St. Petersburg. Alas, in a bizarre turn of circumstances, he is swallowed by the crocodile. Unlucky man! Yet, upon being informed of this misadventure, Ivan Matveitch's colleague grimly observes, I always believed that this would be sure to happen to him.1 A satire of the author's contemporaries and an allegory of Russia's ambiguous relationship with Europe, this tale also offers a plausible description of how France perceives America today. We have entered an age of renewed polemic and counterblasts. Such traditional sore spots as food and film (still reliable sources of outcry, when tweaked) become even more tender in times of divisive foreign policy. Geopolitics has the power to resurrect cliches, give them new life, sometimes even make them true. A cover story for the Times Literary Supplement recently offered to explain Why the French Hate America.2 At present, America and antiAmericanism receive more attention than ever before. Indeed, the crocodile has come to town.
Identical two-particle interferometry in diffraction gratings

Field: Physics and Astronomy (Physical Sciences)

We study diffraction and interference of indistinguishable particles. We consider some examples where the wavefunctions and detection probabilities can be evaluated in an analytical way. The diffraction pattern of a two-particle system shows notorious differences for the cases of bosons, fermions and distinguishable particles. In the example of near-field interferometry, the exchange effects for two-fermion systems lead to the existence of planes at which the probability of double detection is null. We also discuss the relation with the approach to systems of identical particles based on correlation functions. In particular, we shall see that these functions reflect, as in noise interferometry, the underlying periodic structure of the diffraction grating.