jimnoneill/paper-to-field-training huggingface dataset:
Quantitative Expression of Telomerase Treated with in Human Gastric Cancer Cells BGC-823

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Objective Purpose on using the changing amount of telomerase to explore the affective value of herba hedyotidis diffusae on human gastric cancer cells BGC-823. Method To implant the human gastric cancer cells BGC-823 with different density of proficiency of herba hedyotidis diffusae externally for 24 h,then to verify the effectuation of herba hedyotidis diffusae using fluorescence mark. Result The number of human gastric cancer cells BGC-823 telomerase reduced by the impact of the hedyotidis diffusae and it appeared dependency of dosage. Conclusion Herba hedyotidis diffusae has distinguished value for restraining human gastric cancer cells BGC-823,and could be a new anti-cancer medicine.
Disability in teenage fiction: A critical evaluation

Field: Arts and Humanities (Social Sciences)

The research for this paper was carried out as part of a masters dissertation for the School of Information Studies at the University of Central England in Birmingham, UK. The paper explores the position of disability in society and the role of fiction in educating teenage readers about the experience of disability, as well as enabling the reader with a disability to identify with fiction. The author, who herself has a disability, analysed bibliographies and guides to disability, devised a set of criteria for selection and carried out a small reader survey.
Quality of life of cerebral palsy patients and their caregivers: A cross sectional study in arehabilitation center Khartoum-Sudan (2014 – 2015)

Field: Health Professions (Health Sciences)

ABSTRACT Background: Cerebral palsy (CP) is group of disorders characterized by long-term disabilities that affect the quality of life (QoL) of both patients and those caring for them. Objective: The objective of this study was to measure the QoL of CP patients and their caregivers and determine the factors affecting both of them. Methods: This was a cross-sectional facility-based study. 65 caregivers of children with CP aged 4–18 years completed a self-structured questionnaire. Descriptives of the samples were displayed, and logistic regression was used in the analysis. Results: The scores of overall QoL of both children and caregivers were low, however, variations were observed among different domains. Both health-related and sociodemographic factors were found to affect the QoL of children and caregivers. The increase in the degree of disability and presence of complications decreased the children QoL while the availability of health insurance improved it. Whereas the QoL of the caregiver was affected by his/her occupation, the degree of child disability did not affect it. Conclusions: This study showed that many feasible changes can be adopted to improve the QoL of CP patients and their caregivers.
Factors related to Coronary Artery Disease in Korean Adults: Based on the Korean National Health and Nutrition Examination Survey 2013~2015

Field: Nursing (Health Sciences)

Purpose: The purpose of this study was to identify the factors related to coronary artery disease in Korean adults. Methods: This study analyzed cross-sectional data collected from 11,103 Korean adults aged 40 years and older who participated in Korean National Health and Nutrition Survey VI (2013~2015). Data were analyzed with descriptive statistics, Rao-Scott xSUP2/SUP test and logistic regression with IBM SPSS v.23. Logistic regression examined whether variables in 3 domains - socio-demographic, lifestyle and health related factors were associated with coronary artery disease. Results: The prevalence of coronary artery disease was 3.16% of the population. Coronary artery disease was associated with older age, spouse, smoking, stress, obesity, poorer self reported health, hypertension, dyslipidemia, and diabetes mellitus. Conclusion: This study suggested that comprehensive nursing intervention should include associated variables in order to reduce the prevalence of coronary artery disease.
MESENTERIC ANGIOGRAPHY OF NON-TROPICAL SPRUE

Field: Medicine (Health Sciences)

Detailed angiographic findings in 2 cases of proved sprue are described. There are dilatation of the superior mesenteric artery and its small bowel branches selectively, and increased capillary blush. Early draining into dilated veins is also noted. These findings are similar to those of the superior mesenteric arteriogram performed with pharmacological vasodilators. This similarity suggests that the dilated vessels in non-tropical sprue may be due to capillary dilatation.
BICAMERAL SYSTEM IN THE PRACTICE OF ORGANIZING THE INDONESIAN PARLIAMENT (A Study of The Transformation of The Regional Representative Council Into The Second Chamber in The Parliamentary System In Indonesia)

Field: Social Sciences (Social Sciences)

The Indonesian Parliament after the amendment to the 1945 Constitution of the Republic of Indonesia practiced an incongruent patterned bicameral system. It was called incongruent Because The first room was different from the second room. The first room (DPR) is a political representation while the second room (DPD) is a territorial/regional/regional representation and soft character, Because The Council's legislative functions and authority are limited to Certain fields. The problem is What is the style and character of the Indonesian Parliament after the changes to the 1945 Constitution of the Republic of Indonesia? How is the system of checks and balances (supervision and balances) in people' s representation in Indonesia fulfilled through a bicameral parliamentary system? How is the Transformation of the Regional Representative Council of the Republic of Indonesia into the second room in the Indonesian parliament to Realize popularism led by wisdom in Deliberation/representation in Indonesia? The research method in this dissertation is legal research with a normative Juridical approach. The results of his research are that the ideal building of the Indonesian parliament in the future must be developed into a strong bicameralism system. MPR membership consists of DPR and DPD. MPR as a joint session. The MPR is no longer an independent institution. It is only a forum for meetings between 2 (two) institutions items, namely the Council and the Parliament. When the trial takes place, both Council members and the House of Representatives members, Werner as members of the Council and the Parliament. They did not join together in an MPR institution.
Functional and structural analyses of amino acid sequence variation in PDC β-lactamase reveal different mechanistic pathways toward cefiderocol resistance in Pseudomonas aeruginosa

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ABSTRACT A wide variety of clinically observed amino acid alterations in the Pseudomonas aeruginosa chromosomal β-lactamase AmpC ( Pseudomonas -derived cephalosporinase [PDC]) are associated with increased resistance to cefepime, ceftolozane/tazobactam, or ceftazidime/avibactam, but their impact on cefiderocol resistance is unclear. We took advantage of a previously engineered collection of wild-type (PAO1) and iron uptake-deficient (PAO Δ piuC ) P. aeruginosa isolates producing 19 distinct PDC variants with substitutions in key catalytic regions. While most variants had moderate effects on cefiderocol minimum inhibitory concentrations compared to PDC-1, the E219K (Ω-loop) and L293P (helix H10) variants significantly affected cefiderocol activity. Kinetic studies revealed that both mutations improve cefiderocol hydrolysis through different enzymatic mechanisms compared to PDC-1 ( K m = 85.29 µM, k cat = 0.0036 s −1 , and k cat / K m = 0.00004 µM −1 s −1 ), leading to enhanced turnover in PDC E219K ( K m = 465.64 µM, k cat = 0.45 s −1 , and k cat / K m = 0.00096 µM −1 s −1 ) and improved affinity in PDC L293P ( K m = 2.69 µM, k cat = 0.0036 s −1 , and k cat / K m = 0.00135 µM −1 s −1 ). These mechanisms are also involved in resistance to ceftolozane and cefepime, identified as the preferred substrates for the E219K and L293P variants, respectively. Molecular dynamics (MD) simulation studies revealed that (i) rigidification of the Ω-loop in PDC E219K promotes optimal accommodation of the R 1 group of cefiderocol, enhancing nucleophilic attack by the catalytic serine; (ii) the less folded conformation of helix H10 in PDC L293P improves cefiderocol accommodation in the active site by establishing stronger hydrogen-bonding interactions with the R 2 group. Our findings demonstrate that the PDC β-lactamase may take advantage of the structural similarities between cefiderocol and other cephalosporins and accelerate hydrolysis by accommodating the E219K or L293P amino acid replacements.
LPS sensitivity in recombinant mice lacking functional alleles at MHCII, Lps and Nramp1 genes

Field: Immunology and Microbiology (Life Sciences)

The Lps gene ( Tlr4) regulates murine responsiveness to bacterial lipopolysaccharide (LPS). This study was designed to test the hypothesis that other genes which control macrophage responsiveness also influence host susceptibility to LPS. We developed a group of recombinant mice to study the link among three genes in the regulation of host sensitivity to LPS and other immune responses; MHCII, Lps, and Nramp1. C2D (MHCII —/ — , Lps n/n , Nramp1 s/s ) mice were crossed with either C57BL10/ScN (MHCII +/+ , Lps d/d , Nramp1 s/s ) or C3H/HeJ (MHCII +/+ , Lps d/d , Nramp1 r/r ) to produce recombinants which are MHCII —/— , Lps d/d , and Nramp1 s/s on two different mouse backgrounds. Here we describe the development and screening of these mice. In addition, we found that the absence of a functional MHCII complex did not significantly impact sensitivity of mice to LPS in a TNFsensitization model. However, mice that carried the Nramp1 s/s genotype were more sensitive to LPS-induced sepsis.
Exploring HIV and AIDS Stigmatisation: Children’s Perspectives

Field: Social Sciences (Social Sciences)

HIV and AIDS-related stigma has been recognised as one of the main obstacles to the prevention, care and treatment of HIV and AIDS. The aim of the research on which this article is based was to examine the experience to stigmatisation of a group of children whose parents have succumbed to AIDS or are living with HIV and AIDS. Semi-structured interviews were conducted with ten children between 13 and 16 years old who were volunteer counsellors and thus well-placed to describe the manifestation of stigma in their community]. Data were analysed through thematic content analysis. The findings show that stigmatisation remains a pervasive experience in the lives of the children of PLWHA. This article suggests that more research should be conducted on how HIV stigma affects the lives of children whose parents are affected by HIV and AIDS in South Africa. DOI: 10.5901/mjss.2014.v5n15p529
On the Binding of Rifampicin to the DNA‐Directed RNA Polymerase from Escherichia coli

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The capacity of RNA polymerase to bind the antibiotic rifampicin is rather sensitive to conditions which lead to conformational changes in the enzyme. Repeated freezing and thawing in 1 M LiCl as well as treatment with guanidinium chloride destroys the binding affinity of the enzyme for the inhibitor. Similarly rifampicin does not associate with any of the isolated subunits α, β or β′. Surprisingly, the reaction of an excess of mercurials with the enzyme leads only to a partial loss of binding capacity suggesting that –SH groups are not directly involved in the formation of the complex with rifampicin. During chain elongation very little rifampicin is bound to the enzyme. Simultaneously enzymatic activity is not affected by the inhibitor. RNA cannot protect the enzyme against the attachment of rifampicin although the binding capacity is reduced. Treatment of the complex of enzyme and antibiotic with RNA does not release rifampicin from the complex. These results support the hypothesis that the tight binding of rifampicin to RNA polymerase is the principal cause of the inhibitory action of the antibiotic.
Incidental solitary hepatocellular carcinomas smaller than 1 cm in size found at autopsy: A morphologic study

Field: Medicine (Health Sciences)

The morphologic features and growth pattern of single hepatocellular carcinomas ≤ 1 cm in size, found incidentally at autopsy, were studied in nine cases. In all but one case, the hepatic parenchyma showed advanced cirrhosis. In three cases, the hepatocellular carcinomas were localized within a regenerative nodule as a form of “nodule within nodule.” The carcinoma was rimmed by nonneoplastic hepatic tissue. A fourth carcinoma consisted of an expansile hepatocellular carcinoma nodule enclosed by a fibrous band of cirrhotic stroma. The remaining five cases consisted of hepatocellular carcinomas which infiltrated the surrounding regenerative nodules or hepatic lobules. These observations suggested that hepatocellular carcinomas arise within regenerative nodules, some of which still retain residual nonneoplastic tissue around the tumor. Others invaded the adjacent liver tissue. The grossly visible fibrous capsule, often seen in more advanced hepatocellular carcinomas, was absent in all cases. All of the hepatocellular carcinomas were well-differentiated. Four cases showed a trabecular pattern with slight sinusoidal dilatation, 3 showed a scirrhous pattern and 2 showed a compact pattern. Their histologic features included marked bile production, Mallory body formation by clusters of tumor cells, resistance to hemosiderin deposition in a markedly siderotic background and loss or decrease of reticulin fibers. These features were hallmarks of small hepatocellular carcinomas. Pathologists should study cirrhotic livers carefully so as not to miss small carcinomas. Clinicians should be aware that even small liver nodules may be hepatocellular carcinomas.
Benelux multicentre trial of alpha interferon treatment for chronic hepatitis C: standard v high dose treatment monitored by biochemical and virological markers (interim analysis). Benelux Multicentre Trial Study Group.

Field: Medicine (Health Sciences)

In an interim analysis of the Benelux trial, no difference in alanine aminotransferase normalisation has been found between the high (6 million units) and standard (3 million units) doses of interferon alfa-2b during the first eight weeks of treatment. The probability of achieving normal alanine aminotransferase activity on at least two successive occasions during treatment is 65% for the standard dose and 73% for the higher dose. Measurement of plasma hepatitis C virus-RNA suggests that hepatitis C virus-RNA negativity after four weeks of treatment is a prerequisite for sustained response to interferon alfa-2b.
Measuring of fissile isotopes partial antineutrino spectra in direct experiment at nuclear reactor

Field: Physics and Astronomy (Physical Sciences)

The direct measuring method is considered to get nuclear reactor antineutrino spectrum. We suppose to isolate partial spectra of the fissile isotopes by using the method of antineutrino spectrum extraction from the inverse beta decay positron spectrum applied at Rovno experiment. This admits to increase the accuracy of partial antineutrino spectra forming the total nuclear reactor spectrum. It is important for the analysis of the reactor core fuel composition and could be applied for non-proliferation purposes.
Profiting from Digitally Distributed Cultural Products: The Case of Content Producers in the Video Games Industry

Field: Business, Management and Accounting (Social Sciences)

Globalization has created new ways of doing business, new institutions to oversee them, and has introduced a spectrum of new protagonists to the international arena. Scholars and practitioners have been challenged by the evolving environment to find new ways to interact and, in the process, many of the traditional boundaries that have existed within and between organizations and institutions have become increasingly blurred. This unique compendium sheds light on these and other topics on the question of change, both within and between organizations and institutions. The contributors have expertly combined the insights of some of the biggest names in the fields of economics, business and strategic management, both present and future – and in doing so offer scholars a tailor-made, up-to-date study on the topic of economic change.
TWO-STROKE-CYCLE GASOLINE ENGINE LUBRICANTS PERFORMANCE AND SERVICE CLASSIFICATION

Field: Chemical Engineering (Physical Sciences)

<div class="section abstract"> <div class="htmlview paragraph">This SAE Standard was prepared by Technical Committee 6, Small Engine Lubricants, of SAE Fuels and Lubricants Division. The intent is to improve communications among engine manufacturers, engine users, and lubricant marketers in describing lubricant performance characteristics. The key objective is to ensure that a correct lubricant is used in each two-stroke-cycle engine.</div> </div>
On the Varieties of Aspergillus Oryzae employed in Shoyu-Manufacture. Part II

Field: Agricultural and Biological Sciences (Life Sciences)

The present author has studied on the amylase and the protease of the typical varieties which wexe studied in the previous works(1)(2). Determinating the diastatic and proteolytic power of wheat bran-koji, and investigating the process of self-digestion of soya bean-koji and starch-koji, the following results have been obtained. (1) The diastaic power of var. No. 6 which is the same with Asp. sojae SAKAGUCHI et YAMADA(3) is very low. (2) There is no relation between the morphological difference (length of stalks) and the power of enzymic activities. (3) The proteolytic power of No.3, No. 6 (Asp. sojae S. et Y.) No. 10, and No. 13, are very high, and these are superior varieties in practical shoyueties manufacture. (4) The diastatic power is inconsiderable for the brewnig of shoyu, but the variwhich have high diastatic power tend to react strongly on sugars.
Enhanced subband JND model with textural image

Field: Computer Science (Physical Sciences)

Just Noticeable Difference (JND) model in transform domain is determined by the contrast sensitivity function, luminance masking and contrast masking. In this paper, we propose an improved JND model with a new method for contrast masking factor estimation. We decompose an image into structural image and textural image, and the textural image is used for an accurate block classification. The proposed algorithm can remove the interference from the edge pixels thus the accurate JND in DCT domain is obtained. Experimental results show that the proposed algorithm can improve the JND thresholds and reduce more data redundancy than the relevant existing JND estimators. This model can be widely used in many image/video processing fields, such as perceptual video coding.
Variability and Reproductive Compatibility Among Populations of Cotesia flavipes from Different Agroclimatic Regions

Field: Agricultural and Biological Sciences (Life Sciences)

Studies were conducted on the variability and reproductive compatibility among exotic (Indonesia) and indigenous (Haryana, Uttar Pradesh, Bihar and Maharashtra) populations of Cotesia flavipes collected on different sugarcane borers from different agroclimatic regions. All the populations of C. flavipes could be successfully reared on the laboratory bred larvae of sugarcane stalk borer, Chilo auricilius. Results indicated variation in biological parameters among different populations of C. flavipes. The parasitoid from Bihar indicated lowest development time (20.7 ± 0.24 days) and highest adult emergence from cocoons (93.15 ± 1.97%), sex ratio (F/M) in the progeny (4.42 ± 0.82) and wasps production by a single female (45.82 ± 9.34) as compared to exotic (Indonesia) and other indigenous (Haryana, Uttar Pradesh and Maharashtra) populations. None of the populations was found to be tolerant to low temperature as the parasitisation by all the populations remained significantly low at 15°C as compared to 25°C. There was reproductive compatibility among different populations of C. flavipes as the female progeny was obtained in all the crosses.
An adaptive physiology-aware communication framework for distributed medical cyber physical systems

Field: Health Professions (Health Sciences)

For emergency medical cyber-physical systems, enhancing the safety and effectiveness of patient care, especially in remote rural areas, is essential. While the doctor to patient ratio in the United States is 30 to 10,000 in large metropolitan areas, it is only 5 to 10,000 in most rural areas; and the highest death rates are often found in the most rural counties. \n \nUse of telecommunication technologies can enhance effectiveness and safety of emergency ambulance transport of patients from rural areas to a regional center hospital. It enables remote monitoring of patients by the physician experts at the tertiary center. There are critical times during transport when physician experts can provide vital assistance to the ambulance Emergency Medical Technicians (EMT) to associate best treatments. However, the communication along the roads in rural areas can range irregularly from 4G to low speed 2G links, including some parts of routes with cellular network communication breakage. This unreliable and limited communication bandwidth together with the produced mass of clinical data and the many information exchanges pose a major challenge in real-time supervision of patients. \n \nIn this study, we define the notion of distributed emergency care, and propose a novel adaptive physiology-aware communication framework which is aware of the patient condition, the underlying network bandwidth, and the criticality of clinical data in the context of the specific diseases. Using the concept of distributed medical CPS models, we study the semantics relation of communication Quality of Service (QoS) with clinical messages, criticality of clinical data, and an ambulance's undertaken route all in a disease-aware manner. Our proposed communication framework is aimed to enhance remote monitoring of acute patients during ambulance transport from a rural hospital to a regional center hospital. We evaluate the components of our framework through various experimentation phases including simulation, instrumentation, real-world profiling, and validation.