jimnoneill/paper-to-field-training huggingface dataset:
6 musical compositions: Colorless green ideas sleep furiously; Wanderings of a youthful mind; Drifting; Present past; Migration miniatures; sb�

Field: Arts and Humanities (Social Sciences)

Composition portfolio submitted for degree. Includes: 1. Colorless green ideas sleep furiously, for piccolo, E? clarinet, violin, celesta/toy piano, and percussion, 2. Wanderings of a youthful mind, for symphonic wind ensemble, 3. Drifting, for saxophone ensemble. 4. Present past, for symphony orchestra, 5. Migration miniatures, for flute, alto saxophone, and cello, 6. sb� [s.b. cubed], for clarinet, violin, and piano.
Contribution of de novo and mosaic TP53 mutations to Li-Fraumeni syndrome

Field: Medicine (Health Sciences)

Background Development of tumours such as adrenocortical carcinomas (ACC), choroid plexus tumours (CPT) or female breast cancers before age 31 or multiple primary cancers belonging to the Li-Fraumeni (LFS) spectrum is, independently of the familial history, highly suggestive of a germline TP53 mutation. The aim of this study was to determine the contribution of de novo and mosaic mutations to LFS. Methods and results Among 328 unrelated patients harbouring a germline TP53 mutation identified by Sanger sequencing and/or QMPSF, we could show that the mutations had occurred de novo in 40 cases, without detectable parental age effect. Sanger sequencing revealed two mosaic mutations in a child with ACC and in an unaffected father of a child with medulloblastoma. Re-analysis of blood DNA by next-generation sequencing, performed at a depth above 500X, from 108 patients suggestive of LFS without detectable TP53 mutations, allowed us to identify 6 additional cases of mosaic TP53 mutations, in 2/49 children with ACC, 2/21 children with CPT, in 1/31 women with breast cancer before age 31 and in a patient who developed an osteosarcoma at age 12, a breast carcinoma and a breast sarcoma at age 35. Conclusions This study performed on a large series of TP53 mutation carriers allows estimating the contribution to LFS of de novo mutations to at least 14% (48/336) and suggests that approximately one-fifth of these de novo mutations occur during embryonic development. Considering the medical impact of TP53 mutation identification, medical laboratories in charge of TP53 testing should ensure the detection of mosaic mutations.
Soaking seeds in methyl jasmonate or benzothiadiazole induces resistance to an insect pest and stem decay inBrassica campestrisL. ssp.chinensis

Field: Agricultural and Biological Sciences (Life Sciences)

SummaryFlowering Chinese cabbage (Brassica campestris L. ssp. chinensis), a leafy vegetable with a flowering stem, is susceptible to larvae of the striped flea beetle (Phyllotreta striolata) during growth, and to stem decay during storage. The aim of this study was to investigate the effects of methyl jasmonate (MeJA) or benzothiadiazole (BTH) applied by seed-soaking on insect damage and on the severity of stem decay in relation to the levels of expression of three defence-related genes. Soaking seeds in 1.0 µM MeJA, or in 24 µM or 240 µM BTH, significantly alleviated pest damage, and soaking seeds in 1.0 µM MeJA or in 240 µM BTH controlled post-harvest decay. These results suggest that seed treatment was effective in enhancing the quality of flowering Chinese cabbage. Applying MeJA or BTH by seed-soaking treatment elevated the levels of expression of the PDF1.2, PR1, and WRKY33 genes at 2, 10, and 20 d after germination, respectively. However, MeJA or BTH applied by seed-soaking only elevated expression of PDF1.2 during storage of flowering Chinese cabbage at low temperature (2ºC) or at room temperature (20ºC). These results suggest that seed treatment with MeJA or BTH can induce plant defence against insect pests and bacterial diseases in flowering Chinese cabbage. The enhanced resistance to insects may involve elevated expression of the PDF1.2, PR1, and WRKY33 genes, while increased resistance to post-harvest decay may be related to up-regulation of PDF1.2.
Risk Management Analysis On The School Activity Plan And Budget Application Information System (ARKAS) Using Cobit 2019

Field: Decision Sciences (Social Sciences)

In the era of globalization and the advancement of information technology, the application of information technology is an important need for educational institutions, including schools. This research focuses on the implementation of the School Activity Plan and Budget Application Information System (ARKAS) at the Palu Safety Center Christian Vocational School to increase efficiency and effectiveness in planning and managing school activities and budgets. However, the implementation of ARKAS is inseparable from various risks that can affect the effectiveness and success of the system. Therefore, risk management analysis is essential to ensure that all potential risks can be identified, analyzed, and minimized. This study uses the COBIT 2019 framework to manage risks in the application of information technology in schools. The study identifies challenges such as resistance to change, resource limitations, and information security risks. This study aims to explore how the implementation of ARKAS in the Palu Safety Army Christian Vocational School can be optimized through risk management analysis using the COBIT 2019 framework. The results of the study show that the use of COBIT 2019 can help in identifying and managing risks effectively, so that the implementation of ARKAS can run more efficiently and transparently. The resulting recommendations are expected to improve the quality of school budget management and become a reference for other schools that face similar challenges in the application of information technology.
Combined analysis of TERT , EGFR , and IDH status defines distinct prognostic glioblastoma classes

Field: Medicine (Health Sciences)

Editors' Note: Commenting on “Combined analysis of TERT , EGFR , and IDH status defines distinct prognostic glioblastoma classes,” Chamberlain argues that, because of the retrospective nature of the study and the heterogeneity in treatment, the article mainly serves to generate a hypothesis. Sanson responds. Lee and Berkowitz discuss the role and utility of neurology missions. —Chafic Karam, MD, and Robert C. Griggs, MD

Labussiere et al.1 analyzed 395 glioblastoma (GBM) patients for mutations in the promoter of the telomerase reverse transcriptase ( TERTp ) gene and …
Dynamics of hydration and dehydration processes of β-cyclodextrin monitored in real time by Raman spectroscopy

Field: Chemistry (Physical Sciences)

The integrated intensity of the O–H Raman stretching band of crystalline β-cyclodextrin hydrate exhibits a linear response to variations of ambient humidity for humidities > 15% and varies with temperature in a similar way as the sample thermogram; it is used to monitor, in real time, the hydration and dehydration processes which follow approximately first-order kinetics.
An Itinerant Mesmerist

Field: Arts and Humanities (Social Sciences)

Mesmerism had its roots in late 18th century France, but it was not until the 1830s in Britain that it was systematically applied to the problem of pain. The application of mesmerism in the clinical setting was extremely contentious and it was with some relief that doctors turned to the far more consistent results of chemical anaesthesia. However, though mesmerism were superseded by chemical anaesthetic agents in many areas of application, mesmerism continued to have a life during the second half of the 19th century. In the 1850s, the decade following the introduction of ether and chloroform, Dr John Elliotson established the London Mesmeric Infirmary, in which he used mesmerism both therapeutically and for pain relief, and established a training programme for apprentice mesmerists. In the mid-1890s on the other side of the globe, Mr Newham Waterworth travelled from Tasmania up the east coast of Australia, performing public demonstrations of mesmerism for pain relief during dental extractions. The first of these took place in Hobart in 1890, more than 40 years after many in Britain had declared mesmerism dead. The extractions were performed by respected dentists and, according to witnesses, Waterworth's mesmerism produced the same effects of insensibility to pain as ether and chloroform. With an examination of the continued application of mesmerism after the advent of chemical anaesthesia, this paper will focus on the work of Newham Waterworth in the 1890s and speculate as to why mesmerism might have resurfaced to some appeal in the Australian colonies in this period.
Food Safety Standards and Export Competitiveness in the Food and Processed Food Industries in Asia-Pacific Countries

Field: Economics, Econometrics and Finance (Social Sciences)

Developing country producers face several constraints related to food safety standards imposed by developed countries. The purpose of this study is to identify factors affecting export flows with respect to food safety standards; and to measure the effects of food safety standards on exports. This study incorporates a food safety variable in a gravity model. The analysis uses aggregate data for bilateral exports of processed food products, and data for factors affecting bilateral export flows for 17 years on 16 OECD and Asia-Pacific countries. The results show that food product exports are negatively affected by aflatoxin standards. A one percent increase in food safety standards decrease exports by approximately one percent. This means that large changes in food standards (which are common these days) will have salutary, deleterious impacts on food exports by developing countries.
MiR-26b reverses temozolomide resistance via targeting Wee1 in glioma cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Emerging evidence has demonstrated that microRNAs (miRNA) play a critical role in chemotherapy-induced epithelial-mesenchymal transition (EMT) in glioma. However, the underlying mechanism of chemotherapy-triggered EMT has not been fully understood. In the current study, we determined the role of miR-26b in regulation of EMT in stable temozolomide (TMZ)-resistant (TR) glioma cells, which have displayed mesenchymal features. Our results illustrated that miR-26b was significantly downregulated in TR cells. Moreover, ectopic expression of miR-26b by its mimics reversed the phenotype of EMT in TR cells. Furthermore, we found that miR-26b governed TR-mediate EMT partly due to governing its target Wee1. Notably, overexpression of miR-26b sensitized TR cells to TMZ. These findings suggest that upregulation of miR-26b or targeting Wee1 could serve as novel approaches to reverse chemotherapy resistance in glioma.
[Tumor lysis syndrome].

Field: Medicine (Health Sciences)

Tumor lysis syndrome(TLS)is a serious complication of anti-cancer chemotherapy due to the spontaneous or therapyrelated rapid lysis of malignant cells. TLS is characterized by hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia, which result in acute renal failure and metabolic acidosis. Factors predisposing to the development of TLS include a higher growth rate of cancerous cells, a higher sensitivity to chemotherapy, impaired renal function before chemotherapy, elevated lactate dehydrogenase and uric acid serum levels, and a large tumor burden such as huge mass formation and extensive bone marrow involvement. Patients with TLS should be treated carefully with proper fluid management, urinary alkalization, correction of acidosis and electrolyte unbalance, inhibition of the formation of uric acid or destruction of the already circulating uric acid molecules, and a reduction of chemotherapy intensity. Furthermore, the recombinant urate oxidase(rasburicase)significantly reduces the morbidity and mortality of TLS. Patients with malignant tumors must be treated with the knowledge that the proper management prior to chemotherapy, an early diagnosis, and an early aggressive treatment can prevent the occurrence of TLS.
Alberta/Haskayne Executive MBA Program

Field: Business, Management and Accounting (Social Sciences)

Abstract. On a typical workday, how many e-mail messages, faxes, and telephone calls do you receive? How many times are you interrupted at work? In this session, participants will complete an exercise, and then the presenters will facilitate a discussion about information overload causes, symptoms and countermeasures. One recent study found that the average North American knowledge worker receives more than 142 communications per day; in the form of e-mail messages, phone calls, face-to-face interruptions, etc. Spira (2005) estimates that unnecessary interruptions consume 28 percent of the average knowledge worker’s day, imposing 28 billion lost hours on American companies each year, at an annual cost of $588 billion. What is Information Overload? Eppler and Mengis (2004) define information overload as simply “receiving too much information. ” The popular notion that information is power, that more information means higher performance, operates only up to a point. Beyond this point, people become overloaded, and more information leads to performance deterioration. It is important to understand causes and symptoms of information overload, along with possible countermeasures to ease it. Causes. According to Kock (2000), the causes of information overload include: time pressure,
Effects of a calcium channel blocking agent, diltiazem, and calciumionophore (A23187) on hepatic cell injury by CCl4 in rat cultured hepatocytes.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

CCl4肝障害におけるCa++の関与を調べる目的で初代培養ラット肝細胞を用いてCCl4処置による肝細胞への45Ca uptakeと肝細胞より逸脱するGOT, LDHを測定した.また, CCl4肝障害に対するCa拮抗剤(Diltiazem), Caイナノフォア(A23187)の影響についても検討した.その結果,CCl4処置による肝細胞への45Ca uptakeと培地中GOT, LDHには正の相関関係(r=0.91, r=0.63)があった.また,DiltiazemはCCl4による肝細胞への45Ca uptakeおよび培地中へのGOT, LDH遊出を有意に抑制した.一方, A23187は, CCl4による肝細胞への45Ca uptakeを増加させる傾向があり,培地中GOT, LDH量も有意に増加させた.以上のことより,CCl4肝障害においてCa++は重要な役割を果たしていると考えられ,DiltiazemはCCl4により生じる肝細胞へのCa uptakeを低下させることにより肝障害を抑制するものと考えられた.
Characterization of solid fuels in oxy-fuel conditions,

Field: Energy (Physical Sciences)

Oxy-fuel combustion is an option for carbon capture and sequestration. This technology is still at the demonstration stage and there are several research needs that should to be satisfied to improve the reliability of this technology. One of the key issues to address is the behaviour of solid fuels switching from traditional air firing to oxy combustion. In this work a methodology to evaluate the properties of solid fuels is described. The experimental work is coupled with a CFD model of the DTR to predict the thermal histories of the coal particles, which can be used to evaluate kinetics according to a previously developed routine. Some preliminary results of firing tests at high heating rate of a Columbian coal with atmospheres at different CO2/O2 ratios are presented. The tests are carried out in a Drop Tube Reactor operating at a nominal temperature of 900 °C. Tests in air and nitrogen are performed for comparison. The results show that in these operating conditions carbon dioxide reduces the conversion of the coal particle, therefore a higher proportion of oxygen is required in Oxy-fuel conditions to match the conversion obtained from air firing. Copyright © 2009, AIDIC Servizi S.r.l.
Experiment of wireless ubiquitous network service using Parlay

Field: Computer Science (Physical Sciences)

The ubiquitous network and various application services are expected to be realized widely. In this paper, the wireless ubiquitous network is defined as the unified network to integrate the mobile wireless network with the fixed IP based network including various access technologies like W-LAN. First, the wireless ubiquitous network architecture is shown which is based on IMS (IP multimedia subsystem) standardized by 3GPP as Release 5. Next, Parlay is described as one of the solution of Open API approach to design and implement the various sophisticated application services. Then the experiment result is shown including the system configuration and application service examples.
Anti-doping and National Politics: An Ethnography in Brazilian Anti-doping Around the Era of the Rio de Janeiro Games

Field: Social Sciences (Social Sciences)

Abstract This study is based on an investigation into the Brazilian anti-doping policy, with a specific focus on the establishment and operational mechanisms of the Brazilian Doping Control Authority (ABCD), under the auspices of the Ministry of Sport (ME). The objective was to describe how Brazilian national policy (general political decisions, interests of parties or particular politicians/agents) affects the fight against doping and, vice versa, how the harmonization process controlled by the World Anti-Doping Agency (WADA) affects national sports policy. A multi-sited ethnographic study was undertaken, involving field diary practices, interviews and document analysis. Adopting the perspective of pragmatic sociology, this study delves into the descriptions of three key periods in the recent history of anti-doping in Brazil: the creation of ABCD and the dissolution of ANAD (National Anti-Doping Agency), the realization of the first 100 anti-doping tests by the ABCD (critical period for its members who managed to keep away ex-officers from ANAD) and the impeachment of the Brazilian president in 2016 (ex-officers from ANAD took over the direction of the ABCD). Our analysis allowed us to conclude that ‘diverting others from decision-making spheres’ comprised a political strategy to occupy spaces of power or to stabilize itself in them, which, in this case, allowed the control of anti-doping actions in the country. Local protagonists tried to make use of international injunctions and pressure or local political events to achieve these goals.
Hiding dark energy transitions at low redshift

Field: Physics and Astronomy (Physical Sciences)

We show that it is both observationally allowable and theoretically possible\nto have large fluctuations in the dark energy equation of state as long as they\noccur at ultra-low redshifts z<0.02. These fluctuations would masquerade as a\nlocal transition in the Hubble rate of a few percent or less and escape even\nfuture, high precision, high redshift measurements of the expansion history and\nstructure. Scalar field models that exhibit this behavior have a sharp feature\nin the potential that the field traverses within a fraction of an e-fold of the\npresent. The equation of state parameter can become arbitrarily large if a\nsharp dip or bump in the potential causes the kinetic and potential energy of\nthe field to both be large and have opposite sign. While canonical scalar field\nmodels can decrease the expansion rate at low redshift, increasing the local\nexpansion rate requires a non-canonical kinetic term for the scalar field.\n
Descemet&amp;rsquo;s stripping and non-Descemet&amp;rsquo;s stripping automated endothelial keratoplasty for microcornea using 6.0 mm donor grafts

Field: Medicine (Health Sciences)

Hideaki Yokogawa,1 Akira Kobayashi,1 Natsuko Yamazaki,1 Yoshiki Ueta,2 Yoshihiro Hashimoto,2 Naoko Tachi,2 Kazuhisa Sugiyama11Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, 2Department of Ophthalmology, Shinseikai Toyama Hospital, Imizu-shi, JapanBackground: The purpose of this paper is to report our experience of Descemet&amp;rsquo;s stripping and non-Descemet&amp;rsquo;s stripping automated endothelial keratoplasty (DSAEK/nDSAEK) for microcorneas using 6.0 mm donor grafts.Methods: Three eyes of two patients (a 56-year-old woman and a 59-year-old woman) with microcornea and suffering from bullous keratopathy were treated with either DSAEK or nDSAEK. A small donor graft (6.0 mm) was inserted into the anterior chamber using a double glide (Busin glide and intraocular lens sheet glide) donor insertion technique. Both patients were followed for at least 12 months. Clinical outcomes, including intraoperative and postoperative complications, visual acuity, and endothelial cell density were evaluated.Results: In all three cases (100%), no intraoperative complications were noted. In one case with a flat keratometry value (32.13 D), a partial donor detachment was noted one day postoperatively, but it was reattached by rebubbling. In another case, rejection was noted 8 months postoperatively, but treatment with systemic corticosteroids was successful. A clear cornea remained in all three cases (100%), with best-corrected visual acuity greater than 20/100 (mean 20/50) at 12 months. Mean postoperative endothelial cell counts were 2,603 &amp;plusmn; 18 cells/mm2 at 6 months (7.4% decrease from preoperative donor cell counts) and 1,799 &amp;plusmn; 556 cells/mm2 at 12 months (36.5% decrease).Conclusion: We report for the first time the successful use of a small donor graft (6.0 mm) for DSAEK/nDSAEK in cases of microcornea. Additional studies using a large number of patients are required to evaluate fully the potential advantages and drawbacks of small diameter donor grafts for microcornea.Keywords: microcornea, Descemet&amp;rsquo;s stripping, non-Descemet&amp;rsquo;s stripping, automated endothelial keratoplasty, small donor grafts
Design and Development of a Haptic Peg-Board Exercise for the Rehabilitation of People with Multiple Sclerosis

Field: Health Professions (Health Sciences)

Peg-in-Hole methods, like the Nine Hole Peg-Board Test (NHPT) and the Perdue board are widely employed for the functional assessment and therapy of the upper limbs of people with Multiple Sclerosis (MS). Such passive devices have been successfully used for many years, however, recent developments and capabilities of haptic interfaces, call for the development of Virtual-Reality versions of these methods. This paper presents the design and development of such a VR based NHPT with kinesthetic feedback that is achieved by means of a 6 DOF Haptic Interface. The physical and mathematical modeling, stability analysis, and numerical implementation are outlined. In addition, kinetic and kinematic tests' procedures and results are presented and discussed. Our investigation showed that in contrast to the traditional NHPT, the computer simulated exercise offers the ability of sampling and analysis of kinematic and dynamic data that can allow for a more quantitative and objective assessment of the user. The system presented, will be the basis for further development and investigation of rehabilitation methods for people with neuro-disabilities.
Place Marketing in Hungary: The Case of Debrecen

Field: Social Sciences (Social Sciences)

After the political transformations in East-Central Europe local authorities were forced to realise that they have to employ more active policy, and consequently, the use of place marketing became more popular. The study examines one particular city in Hungary, Debrecen, and concentrates on two areas. First, it presents what methods were employed in an attempt to attract economic players and tourists, and to increase the satisfaction of existing target groups. Secondly, it evaluates the steps taken: how characteristic were the tools used in Debrecen in other Hungarian cities, and what positive and negative features of marketing activity can be identified.