jimnoneill/paper-to-field-training huggingface dataset:
Safety of prolonged Doxil administration in recurrent gynecologic cancers

Field: Medicine (Health Sciences)

5055 Background: Liposomal doxorubicin (Doxil [D]) has activity in ovarian (OC), tubal (TC), and endometrial (EC) cancers. Since 2nd responses in OC are shorter than the 1st and always followed by relapse, patients achieving maximal response after D-containing doublets or monotherapy, were then continued on D. Methods: 18 patients (after platinum-based induction: 14OC, 2TC, 1EC; or after radiation: 1EC) were treated with D + carboplatin (3), topotecan (9) or taxane (1) doublet trials, or D alone (5). Treatment consisted of D 30–40 mg/m2 given every 4–6 weeks (adjusted to skin tolerance); routine cardiac status (MUGA, ECHO) follow-up was obtained at cumulative doses > 300 mg/m2; duration of treatment and its tolerance are analyzed. Results: 5 continue in complete response (4 OC, 1EC) with D as 2nd line to cumulative doses of 750+, 750+, 760+, 1515+ mg/m2 for 4OC & 390+ mg/m2 for 1EC; time on monotherapy maintenance lasting 22+, 24+, 25+, 57+ & 11+ m vs 34, 13, 8, 7, & 5 m, respectively, for 1st unmaintained interval. In 13, D was given after partial response (8OC, 1EC, 2TC) or in stable disease (2OC), after ≥ 2nd line for median 710 mg/m2 (range 405-1435+) for median 19 m, range (0-37+ m); their preceding treatment-free interval median 7 m, (0–31 m). Confirmed drops in ejection fraction (EF) did not occur during D. An event of shock, neutropenia, and 23% EF occurred 10 m after last D in a patient toxic from oral topotecan; prior EF on D was normal. Ten on continued maintenance have had no changes in EF, alopecia, or bone marrow suppression, –eight have stopped D for progression. Conclusion: Neither clinical cardiac toxicity nor cumulative myelosuppression has been noted on D maintenance; it may lengthen progression-free survival in relapsed OC. Supported by The Chemotherapy Foundation and the Lynne Cohen for Ovarian Cancer Research Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Ortho Biotec Ortho Biotech
Adjuvant treatment of completely resected stage IB-IIIA non-small-cell lung cancer. A retrospective study with cisplatin or carboplatin and oral vinorelbine.

Field: Medicine (Health Sciences)

e18505 Background: Adjuvant chemotherapy is the standard treatment for early stage non-small-cell lung cancer (NSCLC) patients after complete resection. The most evidence-based data exist for the combination of cisplatin (cis) and vinorelbine (vrb), whereas carboplatin (carbo) can be administered as combination partner in cis-unfit patients. To analyze effectiveness and tolerability of platinum-based combination therapy with predominantly oral vrb in daily practice we performed a retrospective study in our hospital. Methods: Data from 152 patients with completely resected NSCLC (stage IB-IIIA) receiving adjuvant chemotherapy with cis or carbo in combination with intravenous or oral vrb (Navelbine Oral) between March 2005 and November 2011 were retrospectively analyzed. Results: Patients were on average 61 years old and diagnosed with stage IB (35%), IIA (5%), IIB (38%) or IIIA (22%) NSCLC. 66% of the patients were male, and 93% were former or active smokers. Vrb was predominantly administered orally (89%) and most patients received carbo (74%). The combination treatment was effective with an estimated 5-year survival of 62% (cis/vrb: 62%, carbo/vrb: 62%) and recurrence-free survival after five years of 61% (cis/vrb: 63%, carbo/vrb: 60%). Toxicities (all grades) related to combination therapy mainly concerned the hematologic system with 70% leukopenia (carbo/vrb: 74%), 32% thrombocytopenia (carbo/vrb: 40%), 40% anemia, 28% neutropenia, and 5% febrile neutropenia. The treatment caused nausea and vomiting in 47% and 23% of the patients (cis/vrb: 59% and 28%), respectively, and fatigue was reported for 23% of the patients. Of note, overall 64% of the patients (carbo/vrb: 71%, cis/vrb: 44%) completed combination therapy with the planned number of cycles. Conclusions: The results of this retrospective study are in line with clinical trials of cis in combination with intravenous vrb and show that adjuvant chemotherapy of a platinum-based combination therapy with vrb is effective. Carbo was better tolerated than cis resulting in superior treatment compliance and comparable effectiveness.
Inhaled nitric oxide prevents left ventricular impairment during endotoxemia

Field: Medicine (Health Sciences)

We evaluated the effect of long-term inhalation of nitric oxide (NO) on cardiac contractility after endotoxemia by using the end-systolic elastance of the left ventricle (LV) as a load-independent contractility index. Chronic instrumentation in 12 pigs included implantation of two pairs of endocardial dimension transducers to measure LV volume and a micromanometer to measure LV pressure. One week later, the animals were divided into a control group ( n = 6) or a NO group ( n = 6). All animals received intravenous Escherichia coliendotoxin (10 μg ⋅ kg −1 ⋅ h −1 ) and equivalent lactated Ringer solution. NO inhalation (20 parts/million) was begun 30 min after the initiation of endotoxemia and was continued for 24 h. In both groups, tachycardia, pulmonary hypertension, and systemic hyperdynamic changes were noted. The end-systolic elastance in the control group was significantly decreased beyond 7 h. NO inhalation maintained the end-systolic elastance at baseline levels and prevented its impairment. These findings indicate that NO exerts a protective effect on LV contractility in this model of endotoxemia.
Examining cultural and gender similarities and differences in college students’ value of communication skills in romantic relationships

Field: Psychology (Social Sciences)

This study assessed and compared the communication skills that native Chinese and native American college students value in the context of romantic relationships. A total of 319 Chinese and 262 American college students responded to questionnaires that assessed the values they placed on six different communication skills. The results showed that the American students valued four of six communication skills more than the Chinese students (i.e. conversational, informative, listening, and narrative skills). The men and women in both cultural groups valued affective communication skills more than instrumental communication skills. In both cultural groups, women placed greater value on affective communication skills than men. The findings also showed a significant mediating effect of gender orientation (masculinity and femininity) on the value placed on communication skills and a significant effect of self-construal, which mediated between nationality and the value assigned to communication skills.
Polyurethane/D-LDH nanocomposites : effects of particle size on shape memory properties

Field: Materials Science (Physical Sciences)

The effect of nano-size filler, layered-double-hydroxide (LDH) on shape memory behavior of polyurethane (PU) nanocomposites was evaluated in this report. The shape memory PU matrix was prepared by polycaprolactone diol (PCL diol), 1,4-butane diol (BD) and 4,4’-methylenebis (phenyl isocyanate) (MDI) and the final PCL-based PU nanocomposites were synthesized by solution mixing with different size dopamine coated LDH fillers in an attempt to reinforce the shape memory PU nanocomposites and to obtain augmentation in shape recovery stress. The relationship between LDH filler size, structure and shape memory performance had been studied. In prior to enhance the interaction between filler and PU matrix, LDH was surface modified by a layer of dopamine, which is a compound that mimics mussel adhesive proteins. The modified LDH dispersed well in the polyurethane to form nanocomposites. From this study, the results showed that a 98% increase in the value of shape recovery stress with the addition of 2 wt% dopamine surface-modified LDH with dimension 38+-9 nm while exhibiting excellent shape fixity and recovery ratio.
Dónde Están Mi Gente?: perceptions of, and support for, professional advancement among latinx/a/o mid-level higher education administrators

Field: Social Sciences (Social Sciences)

Latinx/a/os have significantly increased in number in the US population. The advancement of mid-level Latinx/a/o professionals in higher education is not occurring at the same rate as the increase of the Latinx/a/o population in the country. This study aimed to examine the perceptions of mid-level Latinx/a/os administrators in their workplace experiences in higher education to determine if structural inequality disproportionately impacts Latinx/a/os by relegating them to lower-status positions. A qualitative approach to this study allowed the researcher to interact with participants through interviews and gain a comprehensive understanding of their workplace experiences. A discussion of the study findings in light of earlier analysis and literature on the subject follows. Recommendations for practitioners and methods for implementing these findings are offered as implications for practice. The study's anticipated effect is to expand the body of research supporting mid-level Latinx/a/o administrators in higher education and to improve the practice in this domain.
European Country Contextual Differences Impacting Job Quality Characteristics and Worker Satisfaction: A Look at France and Germany from 1997 to 2005

Field: Social Sciences (Social Sciences)

Prior research has indicated that the nature of work has changed dramatically in recent years in response to economic shifts and an increasingly global economy. In this study, we used non-panel longitudinal data from the International Social Survey Program (Work Orientations II and III: 1997 and 2005-survey questions on job characteristics and job quality) to examine the changing job quality and job satisfaction determinants in two European countries, France and West Germany, while exploring the country contextual and cultural shifts that impacted this change. We used a comparative international methodology to examine similarities and differences between France and West Germany from 1997 to 2005. We used a variety of bivariate and multivariate descriptive statistics and procedures, as well as ordinary least squares and ordered probit regression analysis, to explore variations across the two countries to examine the conditions that exist in France and Germany that may affect the satisfaction of workers within those two countries. To move beyond the existing research of social psychologists and organizational behavior researchers, we utilized descriptive country level comparative data to include important macro-crossnational factors that may directly influence working conditions and the perceptions of workers.
[Effect of radiation on erythrocyte membrane structure using fluorescent probes].

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The effect of electrons with the energy of 5 MeV on the erythrocyte membrane structure was investigated using a fluorescent probe (4-dimethylaminostiryl)-1-methylpyridinium (DSM). Analysis of a competitive binding of DSM and ribonuclease with the erythrocyte ghosts has shown that irradiation causes an increase in the constant of protein association with membranes. It is suggested that a negative surface change increase with irradiation.
An applied studies on diagnosis of hog cholera by reverse transcriptase polymerase chain reaction

Field: Veterinary (Health Sciences)

In this study reverse transcriptase polymerase chain reaction (RT-PCR) was applied to diagnose hog cholera (HC).The result showed that 84 of 135 clinical samples from different places in Guangxi were positive, the rate of positive was 62.2 %.The samples of tonsils and lymph nodes that were collected from healthy pigs from Baise and Liuzhou have been detected.Among 276 tonsil samples of healthy pigs, 37 samples were positive, the rate of positive was 13.4 %.But only one lymph node sample of healthy pig from Yongning indicated positive.In which the samples of tonsil from healthy pigs showed higher rate of positive,35 of 246 tonsil samples were positive. The rate of positive was 14.2%.According to the results,RT-PCR is an useful method that can be applieded to diagnose HC clinically.
On applicability of Hilbert–Huang transform for vibration analysis of a two-member truss

Field: Engineering (Physical Sciences)

The Hilbert–Huang transform (HHT) proposed for treating the time history data of nonlinear dynamic systems comprises two parts: the empirical mode decomposition and the Hilbert transform. In this study, focus is placed on the physical interpretation of the HHT results for an elastic two-member truss, for which the nonlinear behaviour can be clearly interpreted at various stages of excitation, from nearly linear, nonlinear, period-doubling, to chaotic. The instantaneous frequency of the truss is computed using the HHT or derivative-based HHT. In each case, the result obtained by the fast Fourier transform is also presented for comparison. It is concluded that the enforcement by the HHT of the data set to be symmetric with respect to the local zero mean in extracting the intrinsic mode functions may result in frequencies that are not physically meaningful. Care needs to be taken when using HHT for interpreting the frequency contents of a nonlinear structure.
Lung injury induced by short-term mechanical ventilation with hyperoxia and its mitigation by deferoxamine in rats

Field: Medicine (Health Sciences)

Abstract Background: Long-term mechanical ventilation with hyperoxia can induce lung injury. General anesthesia is associated with a very high incidence of hyperoxaemia, despite it usually lasts for a relatively short period of time. It remains unclear whether short-term mechanical ventilation with hyperoxia has an adverse impact on or cause injury to the lungs. The present study aimed to assess whether short-term mechanical ventilation with hyperoxia may cause lung injury in rats and whether deferoxamine (DFO), a ferrous ion chelator, could mitigate such injury to the lungs and explore the possible mechanism. Methods: Twenty-four SD rats were randomly divided into 3 groups (n=8/group): mechanical ventilated with normoxia group (MV group, FiO2=21%), with hyperoxia group (HMV group, FiO2=90%), or with hyperoxia + DFO group (HMV+DFO group, FiO2=90%). Mechanical ventilation under different oxygen concentrations was given for 4 hours.The HMV+DFO group received continuous intravenous infusion of DFO at 200mg•kg-1•d-1, while the MV and HMV groups received an equal volume of normal saline. Carotid artery cannulation was carried out to monitor the blood gas parameters under mechanical ventilation for 2 hours and 4 hours, respectively, and the PaO2/FiO2 ratio was calculated. After 4 hours ventilation, the right anterior lobe of the lung and BALF from the right lung was sampled for pathological and biochemical assays. Results: PaO2 in the HMV and HMV+DFO groups were significantly higher, but the PaO2/FiO2 ratio were significantly lower than those of the MV group (all p<0.01). The lung pathological scores and the wet-to-dry weight ratio (W/D) in the HMV and HMV+DFO groups were significantly higher than those of the MV group, but score and the W/D ratio were reduced by DFO (p<0.05). Biochemically, HMV resulted in significant reductions in SP-C, SP-D, and GR levels and elevation of XOD in both the Bronchoalveolar lavage fluid and the lung tissue homogenate, and all these changes were prevented or significantly reverted by DFO. Conclusions: Mechanical ventilation with hyperoxia for 4 hours induced oxidative injury of the lungs, accompanied by a dramatic reduction in the concentrations of SP-C and SP-D. DFO could mitigate such injury by lowering XOD activity and elevating GR activity.
OYSTER MUSHROOM CULTIVATION BUSINESS DEVELOPMENT STRATEGY THROUGH SWOT ANALYSIS (CASE STUDY OF THE LIMAU MANIH SEJAHTERA GROUP IN KUBANG VILLAGE, PADANG CITY)

Field: Business, Management and Accounting (Social Sciences)

Mushroom business in Indonesia has very good prospects, Kubang village is one of the areas for oyster mushroom cultivation. While the oyster mushroom cultivation business in Kubang Village, Pauh Subdistrict, Padang City still does not meet customer demand and the strategy applied is still fairly manual. To solve these problems, the researchers took a qualitative approach with collecting techniques in the form of interviews, observations and documentation. The analysis technique used is swot analysis. From the results obtained, it was found that the oyster mushroom cultivation business of the Limau Manih Prosperous group has the best strategy, namely the growth and four other strategies that can be applied to the SO (growth) strategy, namely giving bonuses to each customer and retaining old customers and expanding market segments such as stalls. eat, supermarket. Maintaining an affordable price with this could be one of the reasons consumers are attracted to mushrooms. ST strategy (diversification) is to diversify products, to innovate to address consumer tastes. The WO (stability) strategy is to take advantage of the role of technology, and create opportunities to make their own raw materials. The WT (defense) strategy is to create a trademark or label and can take advantage of the role of the government in obtaining a permit
NEUTRON DIFFRACTION STUDIES OF WATER IN AMBIENT, SUPER-COOLED AND AMORPHOUS STATES

Field: Physics and Astronomy (Physical Sciences)

The structure of liquid water in the stable and metastable phases is dominated by the orientational effects of hydrogen-bonding on the local molecular environment. As the temperature is reduced the hydrogen-bond connectivity is increased and the structural features of the super-cooled state appear to be evolving towards the continuous random network structure of low-density amorphous ice. The use of neutron diffraction techniques for the study of liquid water and amorphous ice shows how the variation in the orientational correlations influences the properties. Water has a delicate structure which is sensitive to various external parameters such as temperature and/or pressure which can be understood in terms of the hydrogen-bond connectivity. The presence of apolar atoms in this environment perturbs this network and recent studies have shown how the water molecules can form clathrate type cages around the isolated atom.
Patrick Tresset: Human Traits and the Art of Creative Machines

Field: Arts and Humanities (Social Sciences)

October 01 2018 Patrick Tresset: Human Traits and the Art of Creative Machines Patrick Tresset: Human Traits and the Art of Creative Machines edited by Ryszard W.Kluszczyński. Laznia Centre for Contemporary Art, Gdańsk, Poland, 2016. 205 pp., illus. Paper. ISBN: 978-8361646730. Rob Harle Rob Harle Search for other works by this author on: This Site Google Scholar Author and Article Information Rob Harle Online Issn: 1530-9282 Print Issn: 0024-094X ©2018 ISAST2018ISAST Leonardo (2018) 51 (5): 537–538. https://doi.org/10.1162/leon_r_01676 Cite Icon Cite Permissions Share Icon Share Facebook Twitter LinkedIn MailTo Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation Rob Harle; Patrick Tresset: Human Traits and the Art of Creative Machines. Leonardo 2018; 51 (5): 537–538. doi: https://doi.org/10.1162/leon_r_01676 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsLeonardo Search Advanced Search This content is only available as a PDF. ©2018 ISAST2018ISAST Article PDF first page preview Close Modal You do not currently have access to this content.
Mechanisms of intrinsic and acquired resistance to kinase‐targeted therapies

Field: Medicine (Health Sciences)

Summary Cancer drugs that target pivotal signaling molecules required for malignant cell survival and growth have demonstrated striking antitumor activities in appropriately selected patient populations. Unfortunately, however, therapeutic responses are often of limited duration, typically 6–12 months, because of emergence of drug‐resistant subclones of tumor cells. In this review, we highlight several of the mechanisms of emergent resistance to several kinase‐targeted small molecule therapies used in melanoma, non‐small cell lung cancer ( NSCLC ) and other solid tumors as illustrative examples. We discuss the implications of these findings for the development of new treatment strategies to delay or prevent the onset of drug resistance.
Screening Tests for Carcinoma of the Cervix

Field: Medicine (Health Sciences)

Keepingthe Heart Going" (19 June, p. 1566) we believe that incorrect emphasis has been placed upon the risks of the production of ventricular fibrillation by pacing on the T wave in patients who have returned to sinus rhythm.All proved instances of ventricular fibrilla- tion, in our experience, have occurred only with the epicardial system of pacing, and only in the immediate post-thoracotomy period.'It seems that the risk of ventricular fibrillation is highest when the threshold for the production of ventricular fibrillation is lowered from superficial myocardial damage caused by stitching the electrode on to the epicardium and from alterations in pul- monary ventilation due to the thoracotomy.Another facotor was probably the unnecessarily high power of the earlier units.Now that we use endocardial jugular sys- tems for long-term pacing, thereby avoiding a thoracotomy, the risk of ventricular fibrillation must be greatly reduced, and we have never seen it in our experience of over 100 patients treated by endocardial pacing.-We
GLOBAL VALUE CHAINS: WORLD TRENDS AND THE RUSSIA’S INVOLVEMENT

Field: Economics, Econometrics and Finance (Social Sciences)

The paper considers the main theoretical approaches to understanding global value chains (GVC) and analyzes their role in the modern global economy. It is emphasized that in view of the growing political and economic importance of the GVC, today this phenomenon is in the focus of many countries and international institutions including the «Group of Twenty» (G20), the Organization for Economic Cooperation and Development (OECD), the World Trade Organization (WTO), the United Nations Conference on Trade and Development (UNCTAD) and the World Bank. To describe the major world trends in the GVC and characteristic aspects of Russia’s involment in the GVC, the paper uses, inter alia, the most recent data obtained through applying the TiVA (Trade in Value-Added) methodology which was developed jointly by the OECD and the WTO.The current state of Russia’s participation in the GVC proves that Russia is mainly involved in the upstream GVC part (i.e. other countries use exported Russian goods as raw materials or components in their production). The current position of Russia in the GVC does not provide long-term benefits for our country nor meet the medium and long-term objectives of social and economic, scientific and technological development.The authors explore the barriers as well as factors facilitating the participation of Russia in the GVC. In conclusion, recommendations are made to improve the effectiveness of Russia’s involvement in the GVC. The suggested measures include both horizontal measures related to the comprehensive modernization of the economy and public administration as well as measures aimed at a more adequate assessment, monitoring and forecasting of participation in the GVC through active international cooperation in this field.