jimnoneill/paper-to-field-training huggingface dataset:
ChemInform Abstract: Electronic Effects of Substitution and Reconstruction of the Coordination Polyhedron in Adducts of Main Group IV Element Halides

Field: Chemistry (Physical Sciences)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Analysis of cross-border free route implementation: A case for Turkish and Ukrainian airspaces

Field: Engineering (Physical Sciences)

Abstract Free route airspace (FRA) are increasingly widespread in European countries. A step further, cross-border FRA aims to implement FRA in a seamless,defragmented airspace in Europe. This study aims to bring a different perspective by extending the scope of cross-border FRA applications beyond socioeconomic status (SES) countries. In the study, analyses were made using fast-time simulation outputs for one of the busiest days of Turkish airspace in 2022. The simulation models of four cases were created and compared in such a way that airspaces of Türkiye, South East Europe free route airspace (SEEFRA) countries and Ukraine combined under different border operations above FL285. Flight trajectories were assessed in terms of flight distance, fuel economy and environmental impact within the aforementioned airspaces. The participation of Turkish airspace in the cross-border region and opening of Ukrainian airspace are examined. Concluded, among all, cross-border FRA implemented through all aforementioned regions (Case 4) may constitute the best benefit for flight trajectories and related variables.
Implementation of “health promoting educational institute” strategies in the state of Himachal Pradesh, India: challenges, opportunities and the way forward

Field: Health Professions (Health Sciences)

Health promotion is the process of enabling people to increase control over, and to improve their health. Schools and other educational institutes can play a vital role in inculcating health promoting behaviour at early stage of life for sustainable health and well-being. A health promoting school is one that constantly strengthens its capacity as a healthy setting for living, learning and working through multi stakeholder engagements. Health Department has a key role in developing strategies and building partnerships for health promotion at school level. Keeping in view these facts, the department of health and education developed the protocol and implementation plan for certification of educational institute as “health promoting educational institute” in the state of Himachal Pradesh in northern India. The World Health Organization (WHO) protocol for health promoting schools (HPS) has been adopted with some state specific modifications which came into force from 6th November 2020 through a notification by the state government. However, the process of certification got delayed due to the COVID pandemic and closure of the schools. The institutional ethics committee (IEC) activities and capacity building measures were strengthened and Government Senior Secondary School Mahunag in district Mandi with strength of 120 students from 6-12th class was certified as the first health promoting educational institute in the state on 18th December 2021. The purpose of this study is to discuss the process for certification of health promoting educational institute in the state of Himachal Pradesh so that the strategy can be replicated in similar settings.
1H NMR-based metabolomics approach to understanding the temperature-dependent pathogenicity of Lactococcus garvieae

Field: Immunology and Microbiology (Life Sciences)

Lactococcus garvieae is known as main agent of the bacterial diseases, Lactococcosis in trout farms. The present study was aimed to study the metabolic bases of the temperature-dependent pathogenicity of the L. garvieae using 1H NMR spectroscopy. The bacteria were grown at different temperatures, including 10, 14, 18 and 22˚C and then the metabolites extracted, identified and quantified. The results of PLS-DA analysis clearly separated the experimental treatments. The main metabolites responsible for this separation were acetate, acetoacetate, creatine phosphate, succinylacetone and trehalose. Furthermore, the result of the analysis of variance indicated also significant differences in metabolome content between temperature treatments. The bacteria exposed to higher temperatures showed more concentration of acetate and acetoacetate compared to those grown at 10°C. The concentrations of trehalose were higher in the bacteria grown at 14 and 18°C compared to other temperature treatments. The higher levels of succinylacetone were found in the bacteria exposed to the temperature less than 14°C compared to those grown at 18 and 22°C. The creatine phosphate concentrations increased with temperature, however, a significant decline occurred at 22°C. The levels of isoeugenol, methionine and betaine significantly declined with increase of temperature from 10 to 22°C. Also, the concentration of N-Acetylglutamine significantly raised as the temperature increased from 10 to 22°C. In conclusion, the temperature altered the metabolome of L. garvie, which this may be linked to the pathogenicity. The temperature probably affects fermentation, homeostasis, energetic condition and metabolism of amino acids in L. garvieae.
Quantative monitoring of software development by time-based and intercheckpoint monitoring

Field: Computer Science (Physical Sciences)

The paper provides an extension to the methods of monitoring originally developed in the paper by Kitchenham and Walker [1]. It discusses how time-based analysis of the metric information can be used to provide a more continuous form of monitoring to complement the approach taken in that paper. This extension is of particular importance to large or long time scale projects when considerable time and effort is expended between checkpoints.
Global distances, social interdependencies and human proximity: From mutual relationships to shared projectuality

Field: Arts and Humanities (Social Sciences)

Il bisogno degli altri e una costante nella nostra esistenza costellata da incertezze e precarieta. Come intessere relazioni significative, anche in chiave educativa, a fronte di tempi e spazi che sempre di piu assumono valore solo nelpresente sottraendo speranza al futuro? Questo interrogativo fara da sfondo al saggio che intende riflettere sulla necessita di orientarsi in contesti plurali e globali, senza trascurare la specificita di ogni luogo esperienziale. L’intento e di delineare alcuni orientamenti pedagogici per superare i muri di segregazione, eretti per proteggere identita effimere, e per promuovere la crescita consapevole di soggetti dialogici e di comunita generative. La profondita del tempo presente puo costituire il substrato per declinare potenziali cambiamenti e per ampliare le prospettive progettuali del singolo e della collettivita. Andare alla ricerca delle interdipendenze che connotano l’esistere umano significa aver cura dei legami,alimentando processi di conoscenza di se e di partecipazione corresponsabile.Ecco perche, per favorire logiche comunitarie sostenibili, lo sguardo attento dell’educatore non trascura le distanze, le differenze e le disuguaglianze.
Two-Directional Elaboration of Hydroxyacetone under Thermodynamically Controlled Conditions:  Allylation or 2-Propynylation and Aldol Reaction

Field: Chemistry (Physical Sciences)

Enolate generated from O-(tetrahydropyran-2-yl)hydroxyacetone under thermodynamically controlled conditions (1.3 equiv of NaH, THF, 0 degrees C to rt) was allylated at the carbon bearing the protected hydroxy group with very high regioselectively. When tert-BuOH, equivalent to the excessive portion of initially added NaH, was introduced into the mixture followed by addition of aldehyde, aldol reaction took place on the methyl group to give 1-substituted 4-hydroxy-(1E),6-heptadien-3-one in acceptable yields after acidic treatment of the mixture for dehydration and deprotection. Introducing a chiral auxiliary protecting group into hydroxyacetone led to asymmetric allylation though stereoselectivity was around 50% ee. Thus, the hidden aspect of the chemoselective nature of protected hydroxyacetone-derived enolate generated under thermodynamically controlled conditions has opened a new avenue for two-directional elaboration of hydroxyacetone that should be potentially useful in organic synthesis.
Cosinor demonstration of circatrigintan (circavigintan) biorhythm in cell component volume of female urethral ejaculate.

Field: Medicine (Health Sciences)

In urethral expulsions of a multipara, aged 37 years, induced by digital stimulation over a time span of almost one and a half 26-day menstrual cycle, the volume of desquamated cellular component changed, according to two nearly identical versions of cosinor, with the period of 22-27 days, with the acrophase between 17th and 23rd day of menstrual cycle and with the amplitude between 0.5 and 1.2 ml/day. The issue testifies to periodic quantitative changes in squamous cells of vaginal type in female urethra, large paraurethral ducts and trigone of the bladder during menstrual cycle, with maximal desquamation during its secretory phase. A link on stop function of urethral epithelium and thus on female miction problems is suggested.
PUBLIC SERVICE IN FACING OF INDUSTRIAL REVOLUTION 4.0

Field: Social Sciences (Social Sciences)

ABSTRACT The dynamic development of public services has created a new paradigm for the performance of apparatus or bureaucrats as service providers. In the context of the Industrial Revolution 4.0, there are various challenges in the implementation of public services. However, apparatus or bureaucrats are vital factors in the success of public services so that they are demanded to be more competent and professional in their services. Therefore, a practical and efficient bureaucracy model is demanded to eliminate rigid and inefficient bureaucracy in public services. Including eliminating inefficient and ineffective mechanisms of work, sources of abuse of authority that cause corruption and the like. The provi- sion of services to the public in the city of Bandung needs to be further improved in order to provide quality public services. In order to improve public services the Bandung City government should adopt co-production public service models as collaboration program between citizens and public officials. However, the new paradigm of the Industrial Revolution 4.0 is a challenge for the civil serv- ants for providing better and quality public services. Keywords: Bureaucracy, bureaucrat, industrial revolution, public service.
Transient Perceptive Deafness due to Erythromycin Lactobionate

Field: Medicine (Health Sciences)

To the Editor.— Erythromycin may cause adverse reactions of two types: (1) allergic such as fever, eosinophilia, skin eruptions, and cholestatic hepatitis, 1-3 or (2) toxic such as epigastric distress, nausea, vomiting, and diarrhea. 4 We observed two patients who developed transient bilateral perceptive deafness following intravenous administration of erythromycin lactobionate. Report of Cases.— Two women, 65 and 67 years old, were recently admitted to our medical department and found to have subacute bacterial endocarditis superimposed on valvular heart disease. One patient was known to be allergic to penicillin, and the other developed nausea and vomiting while receiving penicillin. The first patient, given 2.1 gm erythromycin administered intravenously for two days and 4.2 gm during 12 hours on the third day, complained of loss of hearing three hours after termination of the infusion. The second patient, who, after penicillin treatment was discontinued, was given 4.2 gm erythromycin intravenously administered during
Simplifying the one-loop five graviton amplitude in type IIB string theory

Field: Physics and Astronomy (Physical Sciences)

We consider the [Formula: see text] and [Formula: see text] terms in the low momentum expansion of the five graviton amplitude in type IIB string theory at one loop. They involve integrals of various modular graph functions over the fundamental domain of [Formula: see text]. Unlike the graphs which arise in the four graviton amplitude or at lower orders in the momentum expansion of the five graviton amplitude where the links are given by scalar Green functions, there are several graphs for the [Formula: see text] and [Formula: see text] terms where each of these two links are given by a derivative of the Green function. Starting with appropriate auxiliary diagrams, we show that these graphs can be expressed in terms of those which do not involve any derivatives. This results in considerable simplification of the amplitude.
Treated vs reported toxic exposures: discrepancies between a poison control center and a member hospital.

Field: Health Professions (Health Sciences)

Statistics accumulated by Poison Control Centers (PCC) are routinely used on the local, regional and national levels by governmental agencies to set policy and direct funding. Incomplete reporting by member hospitals is recognized by PCC as a factor contributing to discrepancies in epidemiological estimates; however little emphasis is classically placed by the PCC on expanding reporting from member hospitals. A 1y retrospective review of patients with toxic exposure presenting to an urban Emergency Medicine Department (EMD) was performed to quantify the lack of concordance between treated and reported toxic exposures. 470 toxic exposures presented over the study period, of which only 123 (26%) were relayed to the regional PCC. Inhalation exposures were least likely to be referred for PCC consultation (3%); whereas PCC consultation was obtained for 33% venomous snake bite cases, and 95% of the cyclic antidepressant ingestions. Clusters of similar exposures resulted in fewer PCC consultations. Understanding each hospital's "profile" for handling toxic exposures, and individualized advertisement by the PCC to their member hospital may increase their data reporting. The statistical significance of their epidemiological studies as well as their revenue may increase.
Integrating an exercise program into opioid agonist therapy: a pilot study on feasibility, fitness improvements, and participation challenges.

Field: Health Professions (Health Sciences)

This pilot study suggests that integrating structured exercise into OAT can be feasible and improve aerobic fitness. However, increased psychological distress and fatigue might indicate the need for additional support. The low attendance rate highlights engagement challenges, emphasizing the need for tailored strategies to enhance participation. Future research should focus on optimizing intervention design to improve attendance and enhance physical and psychological outcomes for individuals in OAT.
133 Assessing the management of heart failure patients in the inpatient hospice setting: a retrospective audit

Field: Health Professions (Health Sciences)

Approximately 900,000 people in the UK have heart failure (HF) with 30–40% dying within a year. The incidence of HF is increasing. Patients have a high symptom burden; patients with HF will have similar numbers of symptoms to cancer patients. As UK life expectancy increases palliative services will need to provide more support to this patient group. This retrospective audit assessed care from Severn Hospice to HF patients admitted to the hospice since November 2015. NICE guideline 'Chronic Heart Failure in Adults: Management' was used as the gold standard. Of 962 patients admitted to the hospice, 13 had a diagnosis of HF. 9 had a primary diagnosis and 4 had HF as a co-morbidity. The majority of patients were referred for symptom control. At admission patients had a mean of 4.38 (range 1–7) symptoms. 9 patients had symptoms not in the NICE guideline including constipation, diarrhoea, anxiety, agitation and hallucinations. The majority had more symptoms at admission than at initial referral (mean 4.84). 9 patients had syringe drivers during their admission; 3 were furosemide infusions. All patients had some advance care planning (ACP). All had a 'do not resuscitate order'. Preferred place of death was documented in 12 patients (1 had no capacity). 9 had a preferred place of care. No patients had an advance directive to refuse treatment. Most ACP was done on admission. Surprisingly few patients with HF are admitted to the hospice. These patients have a significant symptom burden including some symptoms not always associated with HF. This suggests that the needs of HF patients are not being met. As a result efforts are being made to set up a joint HF and palliative care MDT. With this and increasing numbers of patients the hospice will continue to gain expertise in managing these patients.
Analysis of the implementation of the Hospital Component in the Emergency Care Network

Field: Health Professions (Health Sciences)

ABSTRACT This study aims to describe the implementation of the Hospital Component of the Urgent and Emergency Care Network (RUE), and to evaluate the delivery of priority Lines of Care in places that serve as gateways in Brazilian regions, between 2011 and 2019. This is a descriptive and analytical study, using data from the National Registration System of Health Institutions (CNES) of the Ministry of Health. To assess significant differences before and after the implementation of Priority Lines of Care, the Wilcoxon test was used. It was found that the Southeast region had the largest increase, including the implementation of technologically denser care points, followed by the Northeast, South, North, and Midwest regions. The South region stood out for the implementation of Priority Lines of Care. Not only did it implement the most of these lines, but it also increased the number of visits and decreased the average length of stay. The Trauma Line of Care was found to be the most effective, when verifying the number of visits with population growth. It was concluded that the Hospital Component of the RUE has made considerable advance, but regional inequalities are still significant.
Death Receptors at the Molecular Level: Therapeutic Implications

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Since the discovery that activation of a subset of cell surface receptors within the tumour necrosis factor (TNF) receptor superfamily could trigger apoptosis, several members of the TNF superfamily including TNF, CD95L and TNF‐related apoptosis‐inducing ligand ( TRAIL ) have been identified as potentially important targets for cancer therapy. Although systemic administration of TNF or CD95L causes severe toxic side effects, thus hampering their potential application in the clinic, the discovery of TRAIL and its cognate death receptors, TRAIL‐R1 and TRAIL‐R2 , have provided an exciting new opportunity for selective targeting of tumour cells. TRAIL receptor activation has emerged as the most promising approach for death receptor‐targeted therapy while inducing minimal toxicity in the majority of normal cells. Intensive research, including detailed analysis of death ligand–death receptor pairs at the structural level have enabled the development of several different approaches aimed at selective targeting of TRAIL‐R1/TRAIL‐R2 in tumour cells. Key concepts: Death receptor ligands, including CD95L and tumour necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL), are potent stimulators of apoptosis. Unlike TNF and CD95L, which on systemic administration exhibit toxicity, TRAIL is selectively toxic to tumour cells while sparing most normal cells. Although the molecular basis for the tumour selective activity of TRAIL remains to be fully defined, the TRAIL pathway is an attractive therapeutic target for the treatment of cancer. Key discoveries at the structural level have revealed several important features of the molecular interaction between TRAIL and its cognate death receptors, TRAIL‐R1/ TRAIL‐R2, that are critical for TRAIL‐receptor triggering of apoptosis. Based on structural and predicted models of TRAIL in complex with TRAIL‐R1/ TRAIL‐R2, recombinant TRAIL, receptor‐selective TRAIL variants, as well as anti‐TRAIL receptor antibodies have been developed, thus providing the opportunity to target both receptors or selectively target either TRAIL‐R1 or TRAIL‐R2 in tumour cells. In preclinical trials, recombinant forms of TRAIL and agonistic anti‐TRAIL receptor antibodies can synergise with chemotherapeutic drugs and novel chemotherapeutic agents to effectively kill TRAIL‐resistant primary tumour cells. Although early phase clinical trials indicate these agents can be delivered safely and are generally well tolerated as monotherapies, the most attractive use of these agents and their greatest promise for further clinical development will be when used in combination with other cancer treatments.
Resource allocation and scheduling in multimedia CDMA wireless systems.

Field: Engineering (Physical Sciences)

We introduce a novel power allocation and scheduling scheme in a DS-CDMA (Direct Sequence - Code Division Multiple Access) wireless communication system with real-time connections. Generally in a CDMA system all users share the same bandwidth which makes the system, interference limited. Because of this nature of such a system, power control is crucial. Traditionally power control is aimed to have equal received powers at the base station to overcome the near-far effect. We will relax this design objective and explore a different power allocation and scheduling scheme to achieve maximum total throughput in the system. We formulate the optimization problem which achieves the optimum power allocation and scheduling scheme, and then we reduce the optimization problem to a linear programming problem and solve it. We analytically study the intercell interference performance of our scheme. We use our results to discuss and compare our novel scheme with the traditional perfect power controlled CDMA systems, to show that the introduced scheme outperforms tradition perfect power controlled CDMA. We address and suggest solutions to some of the practical problems that arises in applying the suggested scheme and therefore introduce a roadmap of an overlay of the suggested algorithms over existing 3G standards. We investigate some of the statistical properties of the received power levels at the base station as a method of testing a connections suitability to a FiGARO like scheme.
The protective effects of β-sitosterol and vermicularin from Thamnolia vermicularis (Sw.) Ach. against skin aging in vitro

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Aged skin, featured with dryness and wrinkles, has received mounting attention due to its adverse influences on beauty. β-Sitosterol and vermicularin are two common active ingredients of Thamnolia vermicularis (Sw.) Ach., a traditional Chinese medicine, of which the anti-aging effect has been discovered. Their protective performance against skin aging was assayed by co-culturing with skin cells in this work. Results showed that β-sitosterol promoted the biosynthesis of hyaluronic acid by increasing the expression of hyaluronic acid synthases in fibroblasts and enhanced the expression of skin barrier functional proteins including aquaporin 3, loricrin, filaggrin and involucrin in keratinocytes, which conduced to the moisture retention within skin. Moreover, vermicularin might function as an anti-wrinkle agent by preventing the loss of collagen type I. Specifically, vermicularin reduced the amount of reactive oxygen species within hydrogen-peroxide-induced fibroblasts; together with suppressing the activation of mitogen-activated protein kinases, it could inhibit the production of matrix metalloproteinases-1. The present research will contribute to the development of the compounds as anti-aging ingredients for future applications in cosmetic formulations and functional food as well as promote further studies of raw materials containing alike compounds.