jimnoneill/paper-to-field-training huggingface dataset:
Non-muscle Myosin Ii Inhibition at the Site of Axon Injury Increases Axon Regeneration

Field: Neuroscience (Life Sciences)

Abstract

Motor axon regeneration following peripheral nerve injury is critical for motor recovery but therapeutic interventions enhancing this are not available. We conducted a phenotypic screen on human motor neurons and identified blebbistatin, a non-muscle myosin II inhibitor, as the most effective neurite outgrowth promotor. Despite its efficacy in vitro, its poor bioavailability limits in vivo application. We, therefore, utilized a blebbistatin analog, NMIIi2, to explore its therapeutic potential for promoting axon regeneration. Local NMIIi2 application directly to injured axons enhanced regeneration in human and mouse motor neurons in vitro. Furthermore, following a sciatic nerve crush injury in mice, local NMIIi2 administration to the axonal injury site facilitated motor axon outgrowth, muscle reinnervation, and functional recovery. NMIIi2 also promoted axon regeneration in sensory, cortical, and retinal ganglion neurons. These findings highlight the therapeutic potential of topical NMII inhibition for treating axon damage.
IMPACT OF COST FUNCTION ON MINIMIZING THE IMPACT OF PATH LOSS IN INTERNET OF MEDICAL THINGS

Field: Computer Science (Physical Sciences)

Internet of Medical Things is the field dealing with human health monitoring on regular basis. That makes it a well worthy field. Sensors are used to physiological monitor the vital signs. The sensors are small in size and in order to let them work continuously for larger span of time they must enable to work efficiently. In Internet of Medical Things energy efficiency is considered a critical factor because of wireless communication networks. Path loss reduces the signal strength so minimizing path loss plays an important role in terms of power consumption in IoMT. This papers enhances using of Cost Function to efficiently mitigate path loss effects on wireless communication. Using Cost Function enables load balancing in the IoMT routing system so that the transmission becomes efficient and the protocol may have longer span of time.
EXPRESSION OF P73 IN MYELOMA CELL LINES AND PLASMA CELLS OF MULTIPLE MYELOMA PATIENTS

Field: Medicine (Health Sciences)

Background: Multiple myeloma (MM) Is a B-cell malignancy characterised by the accumulation of clonal plasma cells in the bone marrow. Myeloma biology is heterogeneous and this lead to a different clinical behavior. As for other type of cancers, hypermethylation could be a mechanism of resistance in myeloma. Hence, DNA methylation of p73 tumor-suppressor gene can potentially be biomarker for diagnosis or relapse in MM. Aim: The goal of this study was to identify the expression of p73 in myeloma evaluating it in 24 different myeloma cell lines and in multiple myeloma patients. Methods: we evaluated the expression of p73 by q-PCR in 24 HMCL and 6 patients, 2 with MGUS, 2 with MM at diagnosis and 2 with relapsed/refractory MM. We tested the expression of p73 in some HMCL, one per category, by western blot. Moreover, we analyzed the expression of p73 before and after treatment with 5- aza-2-deoxycytidine. Results: 14/21 HMCL (66.7%) did not express p73 to a significant level, 4/21 (19%) have been shown to express the gene and its encoded protein to low levels and only 3/21 (14.3%) expressed p73 to an intermediate level. By western blot, we observed that the protein has a very low concentration in all three categories, considered unexpressed. We have observed that 6/12 (50%) cell lines treated increased the expression of the gene p73 after treatment with 5-aza-2- deoxycytidine, but is not reflected in increasing production of the protein detected by western blot. Finally, we observed that 2/6 (33%) patients expressed the gene at low level and 4/6 (67%) patients did not express p73. Conclusions: Our data do not provide evidence that the expression of p73 may be useful as prognostic indicators at MM diagnosis, because our study is limited to few patients tested. To better define and assess the clinical impact of the p73 expression in MM, it is therefore necessary to test the expression of p73 also in a larger number of patient samples with multiple myeloma. This knowledge may help to develop new markers for detection of minimal residual disease and determine candidate patients for epigenetically targeted salvage therapy regimens.
Analysis of Adhesion and Optical Properties of Composite Powder Using Monodispersed Fine Particles and Its Application to Foundation

Field: Materials Science (Physical Sciences)

単分散微粒子複合粉体 (オーダードミクスチュア : OM) が塗布により, 肌の毛穴やきめの粗さを自然に目立たなくさせる粉体であることを見いだした。そこで, ポリメタクリル酸メチルとナイロンを用いたOMについて, 毛穴モデルを用いて付着特性と光学特性を調べた結果, ナイロンが毛穴に入り, その反射により毛穴部の反射強度が上昇し, ポリメタクリル酸メチルが皮丘に均一付着して, 皮丘部の反射強度が減少し, この反射強度差の縮小のために, 毛穴が見えにくくなっていることがわかった。低屈折率のサブミクロン粒子は皮丘部に最密に付着するが, その際できる規則的な凹凸層を多層干渉膜としてシミュレーションすると, 粒子の屈折率が1.7以下, 粒径が0.4μm付近の時, 大きな反射抑制の効果が期待できることがわかり, 実測の結果とも一致していた。このOMを応用し, 毛穴の目立たない, きめ細かい仕上がりのパウダーファンデーションが得られた。
Conventional and transgenic herbicide‐resistant soybean cultivars yielded similarly across five site‐years in Nebraska

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Soybean [ Glycine max (L.) Moench.] yield is determined by interactions amongst soybean cultivars’ genetic potential, agronomic practices, and environmental conditions. Despite the high adoption of herbicide‐resistant soybean cultivars across Nebraska and the United States, the comparative yield potential of non‐herbicide‐resistant (“conventional”) cultivars in not well understood. A field experiment was conducted at five locations across Nebraska in 2017 and 2018 to determine the effect of row spacing (15 and 30 in), cultivar maturity group (2.2–2.4 and 3.2), and herbicide resistance traits (conventional, glyphosate‐resistant, and glyphosate‐ and dicamba‐resistant) on soybean yield. Narrow row spacing increased the soybean yield in three of five research locations. The soybean yield in Auburn in 2017, Albion in 2018, and Cedar Bluffs in 2018 increased by 11.9, 10.2, and 11.4% in narrow compared with wide rows, respectively. Cultivar maturity group and herbicide resistance traits did not affect soybean yield under weed‐free experimental conditions. These results suggest that growers could benefit from earlier maturity groups, as they provide an opportunity for earlier harvest, allowing growers to better spread their field activities in the fall. The grain yield potential was similar between conventional and transgenic herbicide‐resistant cultivars. Therefore, conventional soybean cultivars can be a viable option when adequate weed management can be achieved through conventional weed management strategies.
21stCentury Global Needs, Globalization and Indian Education

Field: Social Sciences (Social Sciences)

Knowledge and skills are the driving forces of economic growth and social development for any country. Countries with higher and better levels of skills adjust more effectively to the challenges and opportunities of world of work. As India moves progressively towards becoming a ‘knowledge economy’ it becomes increasingly important that the country should focus on advancement of skills and these skills have to be relevant to the emerging economic environment. In the changing global scenario, employment possibilities of graduates and Post-Graduates of general subjects are becoming increasingly limited. The education imparted at degree level is not oriented to the market needs and neither is it skill based. Nowadays we usually face this problem that a person is knowledgeable but not skilled enough to do a particular job. Due to this changing nature of work and employment, individuals now look for more flexible and multi-skilling learning opportunities for mobility across employment sector and geographic locations. The formal education system has not been able to provide these opportunities. In India formal education is almost useless without having the skill based knowledge needed to properly use the information.
Small Landholders in Punjab: Debt, Distress and Depeasantisation

Field: Economics, Econometrics and Finance (Social Sciences)

Contrary to general perception of aff round prosperity in the agricultural sector of Punjab, small land holders are economically non-viable which has pushed them under economic distress. Using primary and secondary data the poper highlights that the small formers were under heavy debt which pushed them towards suicides. The economic surplus of small farm is too low ta meet their production and consumption requirements. As a result the process of depeasantisation started. In woke of slow employment growth in industriol and service sectors and poor skills af such formers, their economic Viability shall have to be improved through pramotion of rurol non-form activities. Similarly, reduction in cost of production by reducing investments in farm machinery through expansion of cooperative agro-machinery service centres, which are currently running successfully under Primary Cooperative Credit Societies, can help improve economic viability of such holdings.
Myocardial viability: known and unknown.

Field: Medicine (Health Sciences)

The assessment of myocardial viability has gained a lot of attention over the past few years. Various imaging techniques, mainly nuclear and echocardiographic approaches, have been developed for this purpose. From the existing data, it has become clear that the presence of dysfunctional yet viable myocardium can predict improvement of regional and global left ventricular (LV) function after revascularization. This issue is most relevant in patients with severely depressed LV function, since in these patients revascularization carries a high (peri-)procedural risk on the one hand, but may substantially improve LV function in some patients. Besides the improvement of resting LV function after revascularization, other end-points may also be clinically relevant, including the response during stress, improvement of exercise capacity, the quality of life and the prevention of LV remodeling. These issues have not been studied extensively thusfar. Finally, several retrospective studies have shown the prognostic value of viability assessment; patients with viable but jeopardized myocardium were significantly more prone to experience cardiac events than patients with viability who underwent revascularization. The different aspects of viability assessment (including pathophysiology, available techniques, current implications and unresolved issues) will be addressed in this manuscript.
Advances in AI-Augmented Network Fault Detection and Self-Optimization in Multi-Layer Mobile Systems

Field: Computer Science (Physical Sciences)

The increasing complexity of multi-layer mobile network systems—comprising the physical, network, service, and application layers—has made fault detection, diagnosis, and self-optimization more challenging and critical than ever. As user expectations for seamless connectivity and high-quality service intensify, traditional rule-based network management strategies have proven insufficient in meeting the demands of real-time responsiveness and operational efficiency. This paper explores the latest advances in Artificial Intelligence (AI)-augmented fault detection and self-optimization techniques for multi-layer mobile systems, offering a comprehensive review and conceptual synthesis of emerging methods. The study presents a multidimensional approach that combines machine learning, deep learning, and reinforcement learning models to detect anomalies, predict failures, and trigger automated optimization protocols. Techniques such as autoencoders for unsupervised anomaly detection, convolutional neural networks (CNNs) for pattern recognition, and deep reinforcement learning for closed-loop self-optimization are critically analyzed. Special emphasis is placed on their application in heterogeneous network environments, including 4G, 5G, and the evolving 6G architectures. Furthermore, the paper introduces a conceptual framework that integrates AI-driven monitoring agents with centralized orchestration layers to ensure cross-layer data correlation, intelligent root cause analysis, and proactive resource allocation. Real-world case studies and simulation results from recent deployments demonstrate significant improvements in fault resolution times, network throughput, and energy efficiency. The framework is also aligned with zero-touch network management paradigms and network slicing strategies, essential for scalable deployment in modern telecom infrastructures. The findings reveal that AI-augmented systems outperform traditional mechanisms in speed, accuracy, and adaptability, ultimately reducing downtime and enhancing user experience. However, challenges such as data privacy, model interpretability, and the need for large-scale labeled datasets remain key constraints. This paper concludes by recommending future research directions focused on federated learning, explainable AI, and hybrid models that combine symbolic reasoning with data-driven approaches to enhance fault resilience and operational autonomy in next-generation networks.
Risk of hypertension (HTN) and malignant hypertension (mHTN) in patients treated for multiple myeloma (MM).

Field: Medicine (Health Sciences)

8049 Background: HTN is commonly reported in patients with MM and may be associated with older age, disease-related complications, or sequelae of MM treatments. This study evaluated incidence rates (IR) of HTN and mHTN in treated MM patients in the United States and the risk of development of mHTN in MM patients with pre-existing HTN. Methods: Newly-treated adult MM patients were identified from Truven MarketScan claims database from 1/1/05 to 3/31/14 using ICD-9 codes to identify disease state, HTN, mHTN, and comorbidities. Inclusion criteria were new diagnosis of MM with start of MM treatment, ≥ 12 months continuous enrollment (CE) prior to diagnosis, prescription drug coverage, and ≥ 30 days of CE following initial diagnosis. Non-MM patients were matched on age (within +/- 5 yrs), gender, and distribution of index dates to MM patients. The risk of HTN and mHTN based on existing HTN and other CV comorbidities were evaluated over time. Results: 7895 MM patients (38% with HTN history) and 23685 non-MM patients (24% HTN history) were included in the study. The IR of HTN in MM and non-MM patients was 260 and 178 per 1000 person-years (PYRs), respectively. The IR of mHTN in patients with and without a history HTN were 10.25 and 3.29 per 1000 PYRs, respectively for MM patients; 4.25 and 1.88 per 1000 PYRs, respectively for non-MM patients. There was a 30% increase in the risk of HTN (HR: 1.30; 95% CI: 1.22, 1.37) in MM vs. non-MM patients. MM patients with (HR: 1.90; 95% CI: 1.26, 2.87) or without (HR: 1.54; 95% CI: 1.04, 2.28) a history of HTN had a higher risk of mHTN events during the observation period vs. non-MM patients. In MM patients with a history of HTN, the risk of mHTN was significantly increased with the following comorbid conditions: cardiomyopathy (HR: 2.79; 95% CI: 1.20, 6.48), renal failure (HR: 2.13; 95% CI: 1.36, 3.34), and diabetes mellitus (HR: 1.59; 95% CI: 1.05, 2.39). Conclusions: This study confirms that the incidence of HTN and mHTN is higher in newly-treated MM patients vs non-MM patients. Existing HTN is a risk factor for MM patients developing mHTN. Management of CV comorbidities in MM patients is important based on the increased risk of HTN and mHTN among patients with these comorbidities.
PROTECTION OF PERSONAL DATA IN FRANCE:

Field: Social Sciences (Social Sciences)

The technological and social expansion of the personal data use including the possibility of their cross-border transfer and exchange increases the risks of their unfair use. The consistency and coherence in resolving issues on legal regulation of relations in the field of personal data protection are demonstrated by the European Union and its member states. Ensuring a uniform and consistent legal regulation at the level of the European Union largely depends on the actions of EU Member States to adopt national laws to implement the European approach, as well as their active participation in the development of new legal acts, the adoption of which is planned at the final stage of the legal regulation reform of protection personal data in the Union. This raises the question of how much the rules of individual states diverge since this significantly affects the practice of applying the common European law on the protection of personal data. Indeed, when introducing the relevant provisions in their legislation, EU countries went in different ways [1]. This paper discusses the approach to the protection of personal data that was used in France
[Cancer of the lower oesophagus. One-stage subtotal oesophagectomy without thoracotomy and retrosternal gastroplasty (author's transl)].

Field: Medicine (Health Sciences)

In the operation proposed the tumour is approached by the abdominal route after incision of the diaphragm. It is dissected and the overlying healthy oesophagus is stripped. Continuity of the digestive tract is re-established by tubular gastroplasty in which the stomach is brought up to the neck through a retrosternal tunnel. The operation is indicated for tumours of the lower and middle oesophagus.
P-477 LESSONS AND LEARNED; THE CHANGING INDUSTRIAL HEALTH NEEDS AFTER THE NUCLEAR DISASTER AND IMPLICATIONS FOR FUTURE DISASTERS

Field: Health Professions (Health Sciences)

Abstract Introduction The Fukushima Daiichi Nuclear Power Plant (1F) accident posed significant challenges to industrial health management. The University of Occupational and Environmental Health, Jaan played a vital role in providing support during the aftermath. Understanding the dynamic changes in industrial health needs over time is crucial for effective disaster response and preparedness. Method The 1F Network Research Meetings, held regularly, facilitated discussions among industrial physicians, experts, and cooperating companies. Through a thorough review of meeting minutes, we categorized the industrial health needs and responses in different post-disaster stages. Result During the initial recovery phase, focus on restoring operations and managing radiation led to oversight of recovery workers’ health and safety. Challenges included inadequate heatstroke prevention during extended summer work, fatigue management from continuous shifts, and insufficient health protocols. After the decision to decommission the plant, the importance of long-term health management for workers became evident, resulting in precise health examinations. The increased risk of internal exposure to alpha nuclides necessitated discussions on screening and countermeasures. Ten years later, cases of cancer with uncertain radiation origins prompted discussions on corporate responsibilities. Discussion The findings highlight the diverse Occupational health needs after nuclear disasters and underscore the need for constant preparedness for future catastrophes. The establishment of external industrial health support teams by the Japanese Ministry of Health, Labor, and Welfare is a positive step. However, maintaining readiness and mechanisms for prompt response remain crucial in navigating crises effectively. Conclusion These insights can guide policymakers and stakeholders in enhancing industrial health strategies and disaster management practices.
PERMAINAN TEKA-TEKI SILANG DALAM PEMBELAJARAN MEMBACA DAN MENULIS BAHASA ARAB

Field: Arts and Humanities (Social Sciences)

An Arabic teacher is a person who has the obligation to introduce, teach, and ensure that students have Arabic language skills. In teaching in the classroom, the Arabic teacher is required to create an effective learning nuance and the material is conveyed and well received by students. Language games are tools / tools used in delivering teaching materials. Language games can also increase students' interest and motivation to learn. This article aims to provide knowledge and insight to Arabic teachers on how to apply / play language games in the form of crossword puzzles in learning to read and write Arabic. The application of the crossword puzzle game is carried out with three stages, namely: the preparation stage, the execution of the game, and the evaluation
If BIM is the solution, what is the problem? A review of the benefits, challenges and key drivers in BIM implementation within the UK construction industry

Field: Engineering (Physical Sciences)

The interest in Building Information Modelling has increased within the construction industry over the past few years, both within the UK and globally. This interest was accelerated in 2011, following the UK Government's announcement that BIM would be mandated on all UK centrally procured public sector projects by 2016. BIM has been described as a game-changing Information Communication Technology and cultural process for the construction sector. This paper provides an overview of BIM. It also outlines the benefits, challenges and the key drivers in BIM implementation within the UK construction industry. Findings from this paper indicate that a shift towards collaborative working within the construction industry is crucial to ensure that BIM is implemented fully and for its benefits to be wholly realised.
Evaluation of resistance to pyrethroid and organophosphate adulticides and kdr genotyping in Aedes aegypti populations from Roraima, the Northernmost Brazilian State

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract

Background. Roraima, the northernmost State in Brazil, borders Venezuela and Guyana. Although mostly covered by the tropical forests, the urban centers of this State are highly infested with Ae. aegypti and endemic for dengue, Zika and chikungunya. Herein we present the levels of Ae. aegypti infestation and number of arboviruses cases between 2015 and 2018 in the studied localities. We accessed the insecticide resistance status of Ae. aegypti populations from the capital Boa Vista, two cities on international borders (Pacaraima and Bonfim) and Rorainópolis bordering Amazonas State, in order to evaluate the chemical control efficacy in these localities. Methods. Tests with World Health Organization (WHO)-like tubes impregnated with the pyrethroid deltamethrin (0.05 and 0.12%) and the organophosphate malathion (0.7%) were conducted with Ae. aegypti from Boa Vista, Pacaraima, Bonfim and Rorainópolis, collected in 2016 and 2018. Genotyping of kdr mutations, related to resistance to pyrethroids, was performed for the SNP variations in the sites 1016 and 1534 of the voltage gated sodium channel gene (NaV) with a TaqMan qPCR approach. Results. Ae. albopictus was absent in our collections, and therefore only Ae. aegypti was tested. All Ae. aegypti populations were susceptible to 0.7% malathion in 2016, however mortality dropped to under 90% in Bonfim and Pacaraima populations in 2018. All populations were resistant to 0.05% deltamethrin in both years. The time that 50% of females suffered knockdown (KdT50) under exposition to 0.05% deltamethrin was 3.3-5.9 fold longer in mosquitoes from the populations compared to the susceptible strain Rockefeller. Only Pacaraima population (2018) remained resistant to 0.12% deltamethrin. The kdr genotyping revealed the absence of the wild-type NaVS haplotype (1016Val + 1534Phe) in the populations from Roraima, signifying that all tested insects had a genetic background for pyrethroid resistance. The double kdr NaVR2 haplotype (1016Ile + 15434Cys) was present in higher frequencies in all populations except Rorainópolis, where this haplotype seems to have arrived recently. Conclusions. These results are important for the knowledge about insecticide resistance status of Ae. aegypti populations from Roraima and will help to improve vector control strategies that may be applied to diverse localities under similar geographical and urban conditions.