jimnoneill/paper-to-field-training huggingface dataset:
Reply on RC1

Field: Earth and Planetary Sciences (Physical Sciences)

Abstract. Empirical study of the isotopic features of river runoff were carried out at three hydrological posts in 3 different river basins: the Zakza river in the center of East European Plane (southwest of the Moscow), the Dubna river (north of the Moscow) and the Sosna river in the south of central region. Samples of river water, groundwater and precipitation for the October 2019–October 2021 were collected at weekly intervals. A significant supply of melted snow during spring freshet is the key factor influencing water regimes for these three river basins; varying degrees of anthropogenic flow regulation are also present. During the observation period, there were fundamentally two completely different conditions in terms of runoff formation. First, October 2019–October 2020, there was abnormal low spring freshet instead there was high rain flood in summer. In October 2020–October 2021 there was a normal intra-annual flow pattern with high spring freshet. The new data of stable isotope signature of river runoff component can help to study the response of a river runoff to changing climate conditions.
Rubinstein-Taybi syndrome and spontaneous keloids

Field: Medicine (Health Sciences)

Journal Article Rubinstein‐Taybi syndrome and spontaneous keloids Get access Angela Goodfellow, Angela Goodfellow Department of Dermatology, Royal Berkshire Hospital, Reading Search for other works by this author on: Oxford Academic Google Scholar R.W. Emmerson, R.W. Emmerson Department of Dermatology, Royal Berkshire Hospital, Reading Search for other works by this author on: Oxford Academic Google Scholar H.T. Calvert H.T. Calvert Department of Dermatology, Royal Berkshire Hospital, Reading Search for other works by this author on: Oxford Academic Google Scholar Clinical and Experimental Dermatology, Volume 5, Issue 3, 1 September 1980, Pages 369–370, https://doi.org/10.1111/j.1365-2230.1980.tb01718.x Published: 01 September 1980
Author_Response_1 – Supplemental material for Prognostic significance of forced vital capacity decline prior to and following antifibrotic therapy in idiopathic pulmonary fibrosis

Field: Medicine (Health Sciences)

Supplemental material, Author_Response_1 for Prognostic significance of forced vital capacity decline prior to and following antifibrotic therapy in idiopathic pulmonary fibrosis by Yuya Aono, Yutaro Nakamura, Masato Kono, Hidenori Nakamura, Koshi Yokomura, Shiro Imokawa, Mikio Toyoshima, Hideki Yasui, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui and Takafumi Suda in Therapeutic Advances in Respiratory Disease
Micro-capteur optique pour la caractérisation des dépôts de pulvérisation en agriculture

Field: Engineering (Physical Sciences)

Le recours aux produits phytosanitaires dans l’agriculture suscite de vifs questionnements compte tenu de leurs effets néfastes sur l’environnement. Différents leviers sont envisageables pour aider les agriculteurs à réduire la quantité de pesticides qu’ils utilisent. L’un de ces leviers consiste à optimiser les rendements de pulvérisation, et donc à pulvériser mieux pour pulvériser moins. C’est dans ce contexte que s’inscrit ce travail de thèse. Il vise à prouver la faisabilité de micro-capteurs optiques à base de guides d’onde RIB, qui permettront à terme une mesure fiable et rapide de la pulvérisation des intrants sur les feuilles des plantes, de sorte à pouvoir l’optimiser. Il se base sur l’hypothèse que le guidage au travers les guides d’onde RIB se trouvera modifié par suite du dépôt de gouttelettes sur leur surface, via l’absorption d’une partie de l’onde évanescente.Des guides d’onde RIB à base de couches minces chalcogénures dont le design a été optimisé par simulation ont été réalisés. Leur réponse vis-à-vis du dépôt de gouttelettes d’eau (principal constituant des pesticides) a ensuite été étudiée. Des expériences menées à la longueur d’onde  = 1,55 µm, où le coefficient d’absorption de l’eau est de 50 cm-1, ont permis de confirmer l’hypothèse de départ. Le dépôt de gouttelettes sur la surface d’un guide entraîne bien une diminution de l’intensité lumineuse transmise, diminution d’autant plus importante que le volume et le nombre des gouttes sont importants, résultats en accord avec les simulations. D’autres expériences menées entre 1 et 2 µm ont permis d’étudier la réponse spectrale en sortie du guide, et d’observer à nouveau les effets du dépôt de gouttelettes d’eau, avec apparition des bandes d’absorption caractéristiques de l’eau à 1,45 et 1,9 µm. Une analyse multivariée a par ailleurs permis d’établir un modèle prédictif, permettant de remonter au volume des gouttes déposées, avec une précision de 0,36 µl.Ces premiers résultats prouvent la faisabilité de micro-capteurs optiques pour la détection de gouttelettes et en font une solution potentielle pour aider les agriculteurs à optimiser leurs procédés de pulvérisation.
Scale-dependent bias from primordial non-Gaussianity with trispectrum

Field: Physics and Astronomy (Physical Sciences)

Abstract We study the scale-dependent bias of the halo power spectrum arising from primordial non-Gaussianity. We present an analytic result of the halo bias including up to the trispectrum contributions. We find that the scale-dependent bias opens a new possibility of probing the relation between the non-linearity parameters fNL and τNL.
Physical Conditions of the Coronal Line Region in Seyfert Galaxies

Field: Physics and Astronomy (Physical Sciences)

The launch of the Infrared Space Observatory and new atomic data have opened a window to the study of high ionization gas in active galactic nuclei (AGN). We present the results of a large number of photoionization simulations of the ``coronal line'' region in AGN, employing new atomic data from the Opacity and Iron Projects. Our grid of line emission spans 8 orders of magnitude in gas density and 14 orders of magnitude in ionizing flux in an effort to identify the optimal conditions in which these lines form. We show that coronal lines form at distances from just outside the broad line region to ~400L_{43.5}^{1/2} pc, in gas with ionization parameter -2.0 < log U(H) < 0.75, corresponding to gas densities of 10$^2$ to 10$^{8.5}$ cm$^{-3}$, with electron temperatures ~12,000K -- 150,000K. A large range of distances from the central source implies significant line width variation among the coronal lines. We identify several line ratios which could be used to measure relative abundances, and we use these to show that the coronal line gas is likely to be dust free.
Non-Base Pairing DNA Provides a New Dimension for\nControlling Aptamer-Linked Nanoparticles and Sensors

Field: Chemistry (Physical Sciences)

DNA aptamers have been recently applied as simple and fast colorimetric sensors for a wide\nrange of molecules. A unique feature of these systems is the presence of non-base pairing oligonucleotides\nin both DNA aptamers and spacers on DNA-functionalized nanoparticles. We report here a systematic\ninvestigation on an adenosine aptamer-linked gold nanoparticle system. When the aptamer overhang and\nthe spacer were aligned on the same side, adenosine-responsive disassembly was inhibited. This inhibition\neffect increased with the length of the spacer, and fully inhibited activity was observed with the spacer\ncontaining more than three nucleotides. In contrast to a linear relationship between the spacer length and\nmelting temperature in double-stranded DNA systems without overhangs, the aptamer system displayed\na nonlinear relationship, with the melting temperature decreasing exponentially with spacer length. Control\nexperiments suggested that this inhibition effect was due to thermodynamic factors rather than kinetic traps.\nA comparison with aptamer beacon systems indicated that nanoparticles may play an important role in this\ninhibition effect, and no specific interactions between the aptamer overhang and spacer were detected.\nThe identity of nucleotides in the spacer did not affect the conclusions. Furthermore, the rate of disassembly\nor color change was slower at lower temperature or higher ionic strength, but was little affected by pH from\n5.2 to 9.2. Therefore, non-base pairing DNA provided another dimension for controlling DNA-linked\nnanoparticles in addition to pH, temperature, or ionic strength, and this knowledge has resulted in the\nmost optimal construct for sensing applications.
Da salvaguarda à valorização: Os monumentos nacionais de Portugal e a abertura ao público em 2023

Field: Arts and Humanities (Social Sciences)

The sixth edition of the Survey of National Monuments in Portugal (IMNP), promoted by the Portuguese Observatory of Cultural Activities (OPAC), presents statistical data for the year 2023, collected between May and August 2024. This study aims to update and deepen knowledge about the use, visitors, and human resources of visitable National Monuments (MN), contributing to the formulation of evidence-based public policies. The results show a stabilization of the universe surveyed (349 MN in 2023) and a slight increase in the response rate (258 MN), with most monuments open to the public. The total number of visitors exceeded 15.6 million, reflecting growth of more than 20% compared to 2022 and consolidating the upward trend observed. The territorial coverage of visitable MN covers all NUTS II regions, with a higher incidence in the North and significant growth in the Central region. There has also been a strengthening of human resources, including permanent staff, although a significant proportion of MNs continue to operate with reduced teams or without dedicated staff. Extensive in nature and based on a questionnaire survey, the IMNP is a fundamental tool for monitoring the enhancement and enjoyment of classified immovable cultural heritage in Portugal.
Wake vortex mechanisms behind cylinders with and without porous coating.

Field: Engineering (Physical Sciences)

An experimental analysis of cylinders with diﬀerent porous coating conﬁgurations was performed to understand how these aﬀect near-wake vortex formation mechanics. Five coating conﬁgurations were produced using metallic foam to evaluate diﬀerent vortex formation parameters, namely the vortex shedding frequency, base pressure, formation length, wake thickness, vortex strength, and vorticity ratio. Existing scaling rules proved unable to describe all the vortex shedding patterns observed with less than six parameters, thus a new scaling was produced. By considering that immediately after detaching from a surface vortical structures will behave similarly unless disturbed, it was possible to reduce the scaling to wake velocity components alone. Results showed the new scaling to collapse the description of the near-wake from the initial six parameters to only four: three vortex relative speeds and vortex shedding frequency. Vorticity losses were shown to correlate with the ratio between vortex rotational speed and detaching shear layer speed with good agreement across all tested conﬁgurations. This validates the description developed of the vorticity losses in the near-wake, based on previous work describing the existence of two ﬂuctuating wake length scales: formation and diﬀusion lengths. In order to study the eﬀect of porous coatings on the coupling between drag and vortex shedding frequency, these were measured when sandpaper coatings and splitter plates were applied instead of metallic foams. Results showed the vortex shedding to be decoupled from drag unlike what had been observed for the metal foam coatings. Similar tests were performed on coating conﬁgurations with porous coatings removed, with results illustrating the combined eﬀect of porous coatings over base pressure and formation length. The well-established capability of porous coatings to decrease the unstable wake oscillations largely responsible for aerodynamic noise is likely to be related to the suppression of the diﬀusion length ﬂuctuations.
CORRELATION BETWEEN THE INITIAL-SURGERY AGE WITH THE HIRSCHSPRUNG’S DISEASE PATIENT STOOLING PATTERNS IN ULIN HOSPITAL BANJARMASIN, SOUTH KALIMANTAN, INDONESIA IN 2012-2015

Field: Medicine (Health Sciences)

Background: Hirschsprung's disease may lead to gastrointestinal obstruction if not appropriately treated. The initial-surgery or colostomy is intended to decompress the large bowel, prevent enterocolitis, and the stooling-patterns can be measured after definitive surgery. Objective: To determine the correlation between initial-surgery age with stooling-patterns. Materials and Methods: We performed an analytic observational study in Ulin Hospital in Banjarmasin, South Kalimantan, Indonesia, from November to December 2015 with a total sample of 31 patients. The initial-surgery age was divided into before and after 30 days, while the stooling-patterns were divided into satisfied and not satisfied. Results: There was no significant correlation between initial-surgery age with stooling patterns. Most of the patients, 18/31 (58.1%), underwent initial-surgery after 30 days, and 23/31 (74.2%) had satisfied stooling patterns after surgery. Conclusion: No significant correlation between initial-surgery age and stooling patterns among Hirschsprung's disease patients.
Study of Catalytic Synthesis Process for Methyl Phenyl Carbamate by Reaction of Dimethyl Carbonate with Aniline

Field: Chemical Engineering (Physical Sciences)

Some kinds of Sn, Ti, Zn and Pb catalysts for methyl phenyl carbamate(MPC) synthesis from dimethyl carbonate and aniline were studied. It has been found that at 170 ℃, after 4h of reaction, using 7.5 mol% of aniline , the PbO catalyst exhibited high activity with 81% conversion of aniline, the catalytic activity of Pb\-3O\-4\|ZnO is higher than that of PbO or ZnO alone.
Abstract 4179: Id3 generated cancer stem-like cells: A microvascular niche for the development of glioma

Field: Medicine (Health Sciences)

Abstract Pro-angiogenic vascular stem cells and angiogenesis are key events in the process of glioma formation. Vascular lesions that arise from a focal budding of endothelial cells have been associated with a poor prognosis in glioblastoma multiforme. Hyper-proliferative endothelial lesions are common in patients with severe brain tumors, however, little is known about the relevance of vascular stem cells in the development of these lesions. We tested the hypothesis that the overexpression of the inhibitor of DNA binding and differentiation protein 3 (ID3) reprograms the molecular signature of endothelial cells to stem-like cells; and we hypothesize that these stem-like cells participate in the development of vascular lesion formation in glioma. We generated ID3 overexpressing cells using the human cerebral microvascular endothelial cell line, hCMEC/D3; and determined the effect of ID3 on molecular stem-like signature and vascular lesion formation. ID3 overexpressing cells resided more in the G0/G1 phase and showed a significantly higher level of stem cell markers CD34, CD133, Oct-4, and Sox-2 than wild-type cells. ID3 overexpressing cells also showed a significant increase in VEGFR3, an endothelial growth factor receptor that has been previously reported to correlate with tumor grade of malignant gliomas. In addition, ID3 overexpressing cells showed increased levels of Pyk2, a kinase that has been shown to control glioma cell migration. In the 3-D culture model, we observed that ID3 was essential for the growth of endothelial spheroids. Our findings demonstrate that ID3 generated vascular stem-like cells have the capacity to participate in vascular lesion formation and that vascular stem-like molecular signatures are regulated in part by ID3. Furthermore, the correlation of ID3 overexpression with an increase in VEGFR3 and Pyk2 suggests the importance of ID3 in malignant glioma endothelium. Assessing ID3 in malignant gliomas on a functional level may enable a better understanding for how the microvascular niche contributes to the development of glioma. A better understanding of how microvascular lesions depend on ID3 may open new avenues for the prevention and treatment of glioma. Citation Format: Jayanta Das, Quentin H. Felty. Id3 generated cancer stem-like cells: A microvascular niche for the development of glioma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4179. doi:10.1158/1538-7445.AM2015-4179
On the origin and meaning of South American Indian potato names.

Field: Agricultural and Biological Sciences (Life Sciences)

On the origin and meaning of South American Indian potato names Get access J. G. Hawkes, M.A., Ph.D. J. G. Hawkes, M.A., Ph.D. Search for other works by this author on: Oxford Academic Google Scholar Botanical Journal of the Linnean Society, Volume 53, Issue 350, October 1947, Pages 205–250, https://doi.org/10.1111/j.1095-8339.1947.tb02558.x Published: 23 December 2008 Article history Accepted: 13 May 2008 Published: 23 December 2008
[Separation and identification of active constituents of Paris vietnamensis].

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Compound 1 is a new spirostanol saponin, and compounds 2, 3, 6-11 were obtained from Paris vietnamensis (Takht.) for the first time. Compounds 3, 4, 6, 8 had cytotoxic bioactivities against tumor cells HepG2 and SGC-7901.
Impact of Point-of-Care Testing on Diagnosis, Treatment and Surveillance of Vaccine-Preventable Viral Infections

Field: Medicine (Health Sciences)

With the advent of a variety of vaccines against viral infections, there are multiple viruses that can be prevented via vaccination. However, breakthrough infection or uncovered strains can still cause vaccine-preventable viral infections (VPVI). Therefore, timely diagnosis, treatment and surveillance of these viruses is critical to patient care and public health. Point-of-care (POC) viral diagnostics tools have brought significant improvements in the detection and management of VPVI. These cutting-edge technologies enable prompt, accurate results, enhancing patient care by facilitating timely treatment decisions. This review delves into the advancements in POC testing, including antigen/antibody detection and molecular assays, while focusing on their impact on diagnosis, treatment and surveillance of VPVI such as mpox, viral hepatitis, influenza, flaviviruses (Dengue, Zika and Yellow fever virus), and COVID-19. The role of POC tests in monitoring viral infection is crucial for tracking disease progression and managing outbreaks. Furthermore, the application of POC diagnostics has shown to be vital for public health strategies. In this review, we also highlight emerging POC technologies like CRISPR-based diagnostics and smartphone-integrated POC devices, which have proven particularly beneficial in resource-limited settings. We underscore the importance of continued research to optimize these diagnostic tools for wider global use for mpox, viral hepatitis, influenza, flaviviruses, and COVID-19, while also addressing current challenges related to their sensitivity, specificity, availability, efficiency, and others.
Formulation and evaluation of tablet dosage forms of nimodipine-modified Gum Karaya co-grinding mixtures

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The aim of the present study was to design nimodipine tablets with fast in vitro release rates using nimodipine-modified gum karaya co-grinding mixtures. Co-grinding mixtures of nimodipine and gum karaya were also prepared to highlight the efficiency of modified gum karaya. Physical mixtures of nimodipine with both the carriers were prepared for comparison. All the solid mixtures were characterized by differential scanning calorimetry and X-ray diffraction studies. Solubility studies and in vitro release rate studies were performed for all the solid mixtures to explain the results. Nimodipine tablets were formulated employing nimodipine-gum karaya/modified gum karaya co-grinding mixtures and their corresponding physical mixtures. The compressed tablets were evaluated for various tablet characteristics including in vitro dissolution rate studies. The best results from the dissolution test were obtained for tablets containing nimodipine-modified gum karaya co-grinding mixtures.
The contribution of socio-demographic and psychosocial factors to life satisfaction

Field: Psychology (Social Sciences)

Life satisfaction continues to be an important construct in the psychosocial study of ageing. It is one of the commonly-accepted subjective conditions of quality of life and seems to be one of the facets of successful ageing, both of which are key concepts in ageing. Research reports that life satisfaction is strongly related to socio-demographic and psychosocial variables. These, however, are mutually dependent interactive variables, and much more attention should be paid to the study of the relative contribution of these two types of factors to life satisfaction. The purpose of the research reported in this article was to discover which socio-demographic conditions and psychosocial factors are the most important, and to decide to what extent they contribute to life satisfaction. A sample of 507 individuals aged 65 and over and representative of the Spanish population in terms of age and gender, were interviewed at home. The results indicate that two socio-demographic characteristics (income and education) influence life satisfaction both directly and also indirectly, through psychosocial factors such as activity (physical activity level, satisfaction with leisure activities, and social contacts), perceived health and physical illness. Among psychosocial factors, activity and health both contribute to explaining life satisfaction. The results are discussed from the point of view of the activity theory of ageing.
Amylase and acid phosphatase activity in potato tubers treated with gibberellic acid and stored at 2°C and 8°C

Field: Agricultural and Biological Sciences (Life Sciences)

Amylase activity was higher in tubers stored at 2°C and mare marked in the soaked ones (both in water and in GA<sub>3</sub>). In the late and difficult-sprouting cv. Uran, sokaing resulted in increased amylolytic activity also at 8°C stored tubers. On the contrary, the acid phosphatase activity was a little higher at 8°C than at 2°C stored tubers. At the former temperature two peaks of activity were marked:, in November–December and February–March.
Interior of Los Angeles Memorial Sports Arena near completion, 1959

Field: Arts and Humanities (Social Sciences)

Photograph. "Cavernous interior of the 22,400-seat arena shows work near completion -- More than 400 reservation, for athletic events, shows, and conventions, are already on file." "3 months ahead of schedule -- Los Angles -- $5,950,000 Memorial Sports Arena is more than 80 per cent completed. -- Workmen, still laboring at speeds which have placed the construction almost three months ahead of schedule, have started putting on the finishing touches. -- That was the word yesterday from officials of the L.E. Dixon Company of San Gabriel, builders of the huge reinforced concrete structure in Exposition Park. -- Amont the 'finishing touches' is the completion of the arena's inward slanting facade which rings the top of the structure. -- Almost 5,000,000 [...] one-inch [...]" -- Examiner clippings attached to verso, dated 30 March 1959. Whittington photo no. 93-93-1.; Streetscape. Horizontal photography.