jimnoneill/paper-to-field-training huggingface dataset:
Negative regulation of cell growth and differentiation by TSG101 through association with p21 Cip1/WAF1

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

TSG101 was discovered in a screen for tumor susceptibility genes and has since been shown to have a multiplicity of biological effects. However, the basis for TSG101's ability to regulate cell growth has not been elucidated. We report here that the TSG101 protein binds to the cyclin/cyclin-dependent kinase (CDK) inhibitor (CKI) p21 Cip1/WAF1 and increases stability of the p21 protein in HEK293F cells and differentiating primary keratinocytes, suppressing differentiation in a p21-dependent manner. In proliferating keratinocytes where the p21 protein is relatively stable, TSG101 does not affect the stability or expression of p21 but shows p21-dependent recruitment to cyclin/CDK complexes, inhibits cyclin/CDK activity, and causes strong growth suppression to a much greater extent in p21+/+ than in p21−/− cells. Conversely, suppression of endogenous TSG101 expression by an antisense TSG101 cDNA causes doubling of the fraction of keratinocytes in the S phase of the cell cycle as occurs during p21 deficiency. Our results indicate that TSG101 has a direct role in the control of growth and differentiation in primary epithelial cells, and that p21 is an important mediator of these TSG101 functions.
Prediction of SARS-CoV-2 Main Protease Inhibitors from Several Medicinal Plant Compounds by Drug Repurposing and Molecular Docking Approach.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Coronaviruses are endemic in humans and infections normally mild, such as the common cold but cross-species transmission has produced some unusually virulent strains which now causing viral pneumonia and in serious cases even acute respiratory distress syndrome and death. SARS-CoV-2 is the most threatening issue which leads the world to an uncertainty alongside thousands of regular death scenes. For this virus, death toll is increasing in. An effective vaccine to cure this virus is not yet available, thus requires concerted efforts at various scales. The viral Main Protease controls Coronavirus replication and is a proven drug discovery target for SARS-CoV-2. Here, comprehensive computational approaches including drug repurposing and molecular docking were employed to predict the efficacy of medicinal plant-based bioactive compounds against SARS-CoV-2 Mpro. Molecular docking was performed using PyRx-autodock vina to analyze the inhibition probability. MPP (6LU7) was docked with 90 phytochemical compounds and docking was analysed by PyRx-autodock vina, Pymol version 1.7.4.5 Edu, and Biovia Discovery Studio 4.5. Furthermore, ADME analysis along with analysis of toxicity was also investigated to check the pharmacokinetics and drug-likeness properties of the antiviral phytochemicals. Remdesivir and lopinavir were used as standards for comparison. Our analyses revealed that the top ten (Azadirachtin, -12.5kcal/mol; Rutin, -9 kcal/mol; Theaflavin, -9 kcal/mol; Astragalin, -8.8 kcal/mol; Isoquercitrin, -8.7 kcal/mol; Hyperoside, -8.6 kcal/mol; Baicalin, -8.4 kcal/mol; Saponin, -8.3 kcal/mol; Sennoside A, -8.3 kcal/mol; Aloin, -8.2 kcal/mol, while Remdesivir and Lopinavir showed -8.2 and -7.9 kcal/mol) hits might serve as potential anti- SARS-CoV-2 lead molecules for further optimization and drug development process to combat COVID-19.
Evaluation of erosion in a two‐way coupled fluid–particle system

Field: Engineering (Physical Sciences)

Abstract In this study, the effects of flow turbulence intensity, temperature, particle sizes and impinging velocity on erosion by particle impact are demonstrated numerically. Underlying turbulent flow on an Eulerian frame is described by the compressible Reynolds averaged Navier–Stokes equations with a RNG k –ε turbulence model. The particle trajectories and particle–wall interactions are evaluated by a Eulerian–Lagrangian approach in a two‐way coupling system. An erosion model considering material weight removal from surfaces is used to predict erosive wear. Computational validation against measured data is demonstrated satisfactorily. The analysis of erosion shows that the prevention of erosion is enhanced by increasing the effects of flow temperature and turbulence intensity and reducing particle inertial momentum. Copyright © 2001 John Wiley & Sons, Ltd.
Fatigue Warning System During Physical Exercise Based on Heart Rate and Oxygen Saturation Using Non-invasive Wearable Sensor

Field: Health Professions (Health Sciences)

This paper presents the fatigue warning system based on heart rate and oxygen saturation monitoring using a non-invasive wearable sensor on the android platform. This study aims to provide an early warning in anticipation of fatigue in real-time during physical exercise. An algorithm to define the level of fatigue when physical exercise is provided in this study. A non-invasive wearable sensor located on the wrist is used to detect the user's heart rate and oxygen saturation and monitor them on the android applications. The user's family gets the notifications and the user's locations when the system detects the indications of the user's fatigue during the physical exercise. The testing is done by jogging on the treadmill under the scenario variations of age, running speed, and running duration to see the effect of physical activity on the heart rates and oxygen saturation. The experiments show heart rate detection, and oxygen saturation accuracies are 93.3% and 91.9%, respectively. The android application warns when the user's heart rate and oxygen saturation are under abnormal conditions. The user's age, running speed, and exercise duration affect the heart rate and oxygen saturation during jogging. The user feels fatigued when reaching above 80% of maximum heart rate and oxygen saturation level under 95%.
Correction: How Accessible Was Information about H1N1 Flu? Literacy Assessments of CDC Guidance Documents for Different Audiences

Field: Health Professions (Health Sciences)

We assessed the literacy level and readability of online communications about H1N1/09 influenza issued by the Centers for Disease Control and Prevention (CDC) during the first month of outbreak.Documents were classified as targeting one of six audiences ranging in technical expertise.Flesch-Kincaid (FK) measure assessed literacy level for each group of documents.ANOVA models tested for differences in FK scores across target audiences and over time.Readability was assessed for documents targeting non-technical audiences using the Suitability Assessment of Materials (SAM).Overall, there was a main-effect by audience, F(5, 82) = 29.72,P,.001, but FK scores did not vary over time, F(2, 82) = .34,P..05.A time-byaudience interaction was significant, F(10, 82) = 2.11, P,.05.Documents targeting non-technical audiences were found to be text-heavy and densely-formatted.The vocabulary and writing style were found to adequately reflect audience needs.The reading level of CDC guidance documents about H1N1/09 influenza varied appropriately according to the intended audience; sub-optimal formatting and layout may have rendered some text difficult to comprehend.
STEADY‐STATE ANALYSIS OF INFILTRATION AND OVERLAND FLOW FOR SPATIALLY‐VARIED HILLSLOPES1

Field: Environmental Science (Physical Sciences)

ABSTRACT: An envelope of steady‐state surface runoff response for a hilislope is established in terms of the probability distribution and spatial arrangement of individual point infiltration capacities and the rainfall intensity. Minimum overland flow is shown to occur when point infiltration capacities are ordered with the highest at the slope bottom, while maximum overland flow occurs when the highest point capacities are at the top of the slope. Equations for envelope curves are developed for both continuous distributions and discretely sampled data; examples for each case are given. Use of the analysis as a rainfall‐runoff model is also discussed.
Aspects of the WIMP quality problem and R-parity violation in natural supersymmetry with all axion dark matter

Field: Physics and Astronomy (Physical Sciences)

In supersymmetric models where the mu problem is solved via discrete R-symmetries, then both the global U(1)_{PQ} (Peccei-Quinn, needed to solve the strong CP problem) and R-parity conservation (RPC, needed for proton stability) are expected to arise as accidental, approximate symmetries. Then in some cases, SUSY dark matter is expected to be all axions since the relic lightest SUSY particles (LSPs) can decay away via small R-parity violating (RPV) couplings. We examine several aspects of this {\it all axion} SUSY dark matter scenario. 1. We catalogue the operator suppression which is gained from discrete R-symmetry breaking via four two-extra-field base models. 2. We present exact tree-level LSP decay rates including mixing and phase space effects and compare to results from simple, approximate formulae. 3. Natural SUSY models are characterized by light higgsinos with mass ~100-350 GeV so that the dominant sparticle production cross sections at LHC14 are expected to be higgsino pair production which occurs at the 10^2-10^4 fb level. Assuming nature is natural, the lack of an RPV signal from higgsino pair production in LHC data translates into rather strong upper bounds on nearly all trilinear RPV couplings in order to render the SUSY signal (nearly) invisible. Thus, in natural SUSY models with light higgsinos, the RPV-couplings must be small enough that the LSP has a rather high quality of RPC.
Squamous Cell Carcinoma of the External Auditory Canal: A Clinicopathologic Study of 20 Cases

Field: Medicine (Health Sciences)

Clinicopathologic findings in 20 patients treated for squamous cell carcinoma of the external auditory canal confirm the generally poor prognosis due to the frequency of advanced disease at the time of diagnosis. Mixed modes of therapy used in these patients over the past two decades reflects the lack of therapeutic guidelines based on controlled trials using a standardized surgical approach with or without preoperative or postoperative radiotherapy. Pathologic studies indicate the need for careful preoperative determination of the extent of spread, histologic typing, and the development of a staging classification for advanced disease. Exfoliative cytological examination is potentially useful in screening patients with chronic otitis media.
The role of related strategic alliances before mergers and acquisitions

Field: Business, Management and Accounting (Social Sciences)

Abstract Using mergers and acquisitions (M&A) deals by companies from the biotechnology and pharmaceutical industry, this study analyzes the role of different types of prior ties between companies. The research distinguishes related alliances into direct and indirect alliances. Related alliances provide access to more information and can reduce transaction costs. The reduction of such costs can lead to a more successful target selection and a more efficient transaction process of the M&A deal because the time from announcement to completion can be reduced. This effect can be explained by trust-building, better access to private information, and certification through related alliances. However, in contrast to other studies, this study does not find statistically significant evidence that supports the hypothesis that alliances increase the post-M&A performance and that alliances are associated with higher announcement returns.
An Examination of ICT Planning Maturity in Schools

Field: Social Sciences (Social Sciences)

Information and communication technology (ICT) has the potential to revolutionize teaching and learning as well as school administration, yet little is known about the maturity of ICT planning in schools and the manner in which schools plan for the acquisition and use of these technologies in the educational environment. However, as school investments in ICT increase and they become more reliant on ICT, effective planning becomes more central to schools’ ability to maximize their use of technology. This research examines ICT planning in schools and proposes a four-stage model of the evolution of ICT planning maturity in schools. The model emerges from case studies conducted in eight New Zealand primary schools and provides insight into the nature of ICT planning in schools and the factors that contribute to planning maturity.Request access from your librarian to read this chapter's full text.
Nadverelementerne og billedsynet

Field: Arts and Humanities (Social Sciences)

The Elements of the Eucharist and their Imageryby Leif KallesenThis paper is concerned with an aspect of the problem of Grundtvig’s doctrine of the relationship between spirit and flesh. The inquiry seeks to prove how, by applying his original imagery to the elements of the Eucharist, Grundtvig overcame the alternative interpretations of the Eucharist, which were wellknown from the history of dogmatics, that is - the realistic (the bread and wine are really Christ’s body and blood) and the symbolic (the elements symbolize the substance of the sacrament). This alternative goes back to the primitive Church, when Irenaeus represented the realistic interpretation and Origen the symbolic. Grundtvig knew both these interpretations and their primitive representatives, and this paper seeks to show how Grundtvig manages to rise above both sides and create his own doctrine of the Eucharist, containing the positive points of both Irenaeus and Origen. Thus Grundtvig agrees with Origen on the unique action of the Word, and from Irenaeus he has learnt to consider the visible and bodily as God’s own and blessed creation. The means to avoid both a symbolic view of the Eucharist, which in itself denies the reality of the created, and a realistic interpretation of the elements, which involuntarily ascribes a sacramental status and supernatural powers to the bread and wine, is Grundtvig’s independent imagery, which is legitimized by and justified by the theology of the Creation. The flesh is a true image of the spiritual and invisible because it is created by an everlasting and invisible God; but the bread and wine are not thereby made spiritual, and therefore they cannot have a spiritual and everlasting effect. Not until God’s Kingdom breaks out visibly will the flesh and the spirit coalesce, and then the bread and wine will realise what previously only the Word could achieve. This view of the final and definitive uniting of spirit and body gives rise to poetic utterances which remind one very much of the forms of expression connected with the realistic interpretation of the elements. In his poetry Grundtvig anticipates the definitive coalescence of spirit and body to such a degree that he can speak of bread and wine as if they already were spiritual, speak of what they will become, and of what the Word alone is up to that point, that is, the nourishment for eternal life. But the prerequisite for these apparently realistic utterances is always an imagery that sees our daily bread as a true image of the bread of life.
A finger-mounted obstacle detector for people with visual impairment

Field: Health Professions (Health Sciences)

impairment. The proposed assistive prototype detects obstacle using ultrasonic sensor in real-time and produce audio feedback using transducer. Many previous studies proposed prototypes that are either heavy, bulky, obstructive or high computational power leading to high power consumption. However, the research successfully designed a prototype to be small, light-weight, non-obstructive, low computational power, low cost, portable and wearable. The proposed prototype can potentially assist people with visual impairment in reducing the rate of collision or accident against obstacles around them.
EphA2 expression is modulated following ischemic conditions <i>in vitro</i> and <i>in vivo.</i>

Field: Neuroscience (Life Sciences)

<p>Wild type primary cortical neurons were used to show expression profiles of EphA2 and its ligands - Ephrins A1, 2 and 3 - using immunocytochemistry. (A–D) Cortical neurons showed expression of EphA2 and Ephrins A1–3 under normal and GD conditions. The neuronal protein lysates obtained from normal and GD conditions were probed for changes in the above-mentioned proteins using immunoblotting. (E–I) Expression of EphA2 and its ligands ephrin-A1, ephrin-A2, and ephrin-A3, was increased following GD for 12–24 h when compared to normal conditions. (J–N) A similar increase in expression was observed <i>in vivo</i> following cerebral I/R when compared to sham conditions. Cell-specific expression profile of EphA2 in the ischemic (24 I/R) brain sections was analysed in peri-infarct regions (200X) (O–P). EphA2 was primarily localized to neurons and blood vessels in the peri-infarct regions. Protein lysates of cortical neuronal cultures subjected to GD for 24 h were analyzed for the apoptotic cell death marker cleaved caspase-3 (Q–R). EphA2<sup>−/−</sup> neuronal cultures showed significantly lower levels of cleaved caspase-3 when compared to wild type cultures. Data are mean ± SEM, n = 3–5. *p&lt;0.05, **p&lt;0.001, ***p&lt;0.0001 relative to sham (<i>in vivo)</i> and normal controls (<i>in vitro)</i> for EphA2, Ephrin A1 or Ephrin A3 blots. Data are mean ± SEM, n = 3. *p&lt;0.05 relative to the wild type controls in Cl.Cas3 blots.</p>
Variance-Based Iterative Model Order Reduction of Equivalent Circuits for EMC Analysis

Field: Engineering (Physical Sciences)

This paper proposes a novel and iterative way to conduct model order reduction (MOR) of linear equivalent circuit models (ECMs) without the use of a state-space representation as a surrogate model. The result is an ECM with a reduced total number of circuit elements but same system behavior. The proposed method is as follows: first, the original ECM is decomposed into smaller subcircuits after which a variance-based global sensitivity analysis by means of polynomial chaos expansion is conducted in order to extract the Sobol indices which measure the relative impact of the circuit elements. The least influential ones are then removed by either shorting them or replacing them by an electric open. The frequency responses of the resulting reduced circuits are then fitted against the original frequency response through nonlinear least squares optimization and by subsequently updating the element values. As opposed to the traditional MOR techniques from systems theory, the proposed approach operates on the ECM themselves directly. Thus, it not only offers additional physical insight into the system at any iteration step but also inherently leads to reduced-order models that are at once stable, causal, and passive. This makes the approach especially useful for practical electromagnetic compatibility problems and analysis. In the following, this novel approach is first described in detail and then applied to different test cases. Finally, a discussion of its limitations will be given.
Investigations of current limiting properties of the MgB<inf>2</inf> wires subjected to pulse overcurrents in the benchtop tester

Field: Engineering (Physical Sciences)

A laboratory scale desktop test system including a cryogenic system, an AC pulse generation system and a real time data acquisition program in LabView/DAQmx, has been developed to evaluate the quench properties of MgB 2 wires as an element in a superconducting fault current limiter under pulse overcurrents at 25K in self-field conditions. The MgB2 samples started from a superconducting state and demonstrated good current limiting properties characterized by a fast transition to the normal state during the first half of the cycle and a continuously limiting effect in the subsequent cycles without burnouts. The experimental and numerical simulation results on the quench behaviour indicate the feasibility of using MgB 2 for future superconducting fault current limiter (SFCL) applications. © IOP Publishing Ltd.
Pharmacotherapy Study Of Albendazole And Mebendazole For Soil Transmitted Helminths Infections In Children

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Soil Transmitted Helminths (STH) infection is a nematode infection of the intestine that requires soil for its transmission. The worms that cause Soil Transmitted Helminths infection include; Ascaris lumbricoides, Trichuris trichiura, hookworms (Necator americanus and Ancylostoma duodenale. The incidence of STH infection is quite high with the highest spread of STH infection in the child age group. Treatment of cases of STH infection is by administering antihelmintic drugs or worming drugs. Although there are four The drugs recommended by WHO, only the two drugs most often used in the treatment of STH infections, namely albendazole and mebendazole. Both drugs have been used for more than 30 years, but cases of STH infection still have a high incidence. That is why this literature review was written aims to describe the efficacy of the two drugs for STH infection in children so that their effectiveness can be assessed.The research method used was a literature review, a literature search was sourced from Proquest, Google scholar, Pubmed, Elsevier and Europe PMC. keywords Albendazole, Mebendazole, Soil Transmitted Helminths Infections, Children. There are 10 selected literatures to be studied in this literature review. The results showed that albendazole had satisfactory efficacy in STH infections caused by Ascaris lumbricoides and hookworms, but reduced efficacy in Trichuris trichiura worms. Mebendazole has satisfactory efficacy in STH infections caused by Ascaris lumbricoides and Trichuris trichiura, but reduced efficacy in hookworms. Albendazole and mebendazole does not cause side effects.
Phase I trial of ICRF-159 in combination with 1.3 bis-(2-chloroethyl)-1-nitrosourea (MeCCNU).

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Both ICRF-159 and methyl-CCNU are agents with antitumor activity against gastrointestinal carcinoma; hence the exploration of this combination for possible synergism. Results of the study involving 19 patients show that bone marrow toxicity is the limiting factor for this combination of drugs. Moreover, a dose of 130 mg/mg of MeCCNU with 800 mg/m2/day of ICRF is well tolerated.
Objective of Expanding Tax Risk Criteria in a Preliminary Analysis

Field: Business, Management and Accounting (Social Sciences)

The article is considered current issues of pre-test analysis, which is an important stage in the control work of tax authorities and affects the increase in the effectiveness of tax control by improving the quality of the selection of taxpayers for inclusion in the plan of on-site tax audits. The criteria applied are considered, how tax risks are assessed. The article also analyzes the possibilities of expanding the list of publicly available criteria for different categories of audited entities. Purposes of writing a research paper: to identify the main issues, Pre-audit analysis of taxpayers, provide additional criteria for assessing tax risks. Conclusions, obtained in the course of the study: directions for improving the quality of pre-test analysis in order to improve the control work of tax authorities.