jimnoneill/paper-to-field-training huggingface dataset:
Perturbation of proton and detergent binding sites in bovine serum albumin by acetimidation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPerturbation of proton and detergent binding sites in bovine serum albumin by acetimidationJoseph Avruch, Jacqueline A. Reynolds, and John H. ReynoldsCite this: Biochemistry 1969, 8, 5, 1855–1859Publication Date (Print):May 1, 1969Publication History Published online1 May 2002Published inissue 1 May 1969https://pubs.acs.org/doi/10.1021/bi00833a012https://doi.org/10.1021/bi00833a012research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Global survey on COVID-19 self-testing using SARS-CoV-2 Ag-RDTs

Field: Health Professions (Health Sciences)

This data is from the Global survey on COVID-19 self-testing using SARS-CoV-2 Ag-RDTs. It was part of the work on developing guidelines for using SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing.
Neurocognitive Correlates of Positive and Negative Syndromes in Schizophrenia

Field: Neuroscience (Life Sciences)

Objective: To identify the neurocognitive correlates of positive and negative schizophrenic syndromes using a battery of information-processing measures as the principal method of evaluation. Method: Fifty-two treated, symptomatically stable, schizophrenic (DSM-III-R) patients and 24 age-matched, healthy volunteers were administered a computerized cognitive test battery (COGLAB). The battery included measures of preattentional, attentional, conceptual, and psychomotor performance. The patients ’ psychopathology was rated with the positive and negative syndromes scale (PANSS), which derived scores for positive symptoms, negative symptoms, general psychopathology, and insight. Results: Compared with controls, schizophrenic patients, as a group, showed significant deficits on all of the neurocognitive tasks. Impaired performance on the backward masking, span of apprehension, and Wisconsin card sorting tasks correlated significantly with negative symptoms (r = 0.27–0.40), general psychopathology (r = 0.29–0.42) and impaired insight (r = 0.34–0.52), but no clear association was found between positive symptom scores and neurocognitive deficits. Conclusions: Schizophrenic patients with predominantly negative symptoms and impaired insight seem to exhibit more severe neurocognitive deficits, which lends support to the evolving concept of schizophrenia subtypes and their distinctive neurobiological mechanisms.
Insights into substrate binding and catalysis in bacterial type I dehydroquinase

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Structural, biochemical and computational studies to study substrate binding and the role of the conserved residues of the DHQ1 (type I dehydroquinase) enzyme active site are reported in the present paper. The crystal structure of DHQ1 from Salmonella typhi in complex with (2R)-2-methyl-3-dehydroquinic acid, a substrate analogue, was solved at 1.5 Å. The present study reveals a previously unknown key role for conserved Glu46, Phe145 and Met205 and Gln236, Pro234 and Ala233 residues, with the latter three being located in the flexible substrate-covering loop. Gln236 was shown to be responsible for the folding of this loop and for the dramatic reduction of its flexibility, which triggers active site closure. Glu46 was found to be key in bringing the substrate close to the lysine/histidine catalytic pocket to initiate catalysis. The present study could be useful in the rational design of inhibitors of this challenging and recognized target for the development of novel herbicides and antimicrobial agents.
Plant Based Legume Extracts as Milk Alternatives - A Review

Field: Agricultural and Biological Sciences (Life Sciences)

Animal based milk and its products have been the most important part of dairy consumption, but then demand has steadily outpaced the consumption since the mid-20th century especially in the last decade. This shift has coincided with a growing consumer preference for vegetative origin milk alternatives, which increasingly come from soy, legumes, nuts, seeds, and grains. This review is focused on the potential of plant-based milk alternatives, including soymilk, chickpea milk, kidney bean milk and cowpea milk as sustainable, nutritious, and functional substitutes for traditional dairy milk. Recent findings highlight advancements in processing methods such as heat treatment, fermentation, and germination, which mitigate anti-nutritional factors, enhance flavor profiles, and improving sensory and nutritional qualities. Emerging legume-based options, beyond the widely consumed soymilk, appear promising to for diversify the-se alternative plant-based milk resources owing to their superior protein quality, bioactive compounds, and environmental benefits. This review also underscores the sustainability of legumes, highlighting their contributions to soil health, nitrogen fixation living little carbon footprints compared to dairy milk and its products. This review affirms that legume-based milk alternatives offer a viable, sustainable solution to global challenges in food and nutrition security and environmental health apart from providing healthier options for lactose-intolerant and saturated fat consumption conscious consumers.
Protection of Streamflow in the Eno River

Field: Environmental Science (Physical Sciences)

Lack of sufficient flow in the Eno River has caused several serious problems within its river basin, including water shortage during dry periods, deteriorated water quality, impaired scenic and aesthetic beauty of the stream, loss of recreational opportunities, and adverse effects on aquatic life forms. Because of rapid urban development within the river basin, increased water demand and adverse effects associated with urbanization are expected to make these problems more serious. In order to acquire and protect streamflows in the Eno River, five approaches are proposed: to increase the river's streamflow during dry seasons; to enhance water availability; to minimize adverse effects associated with urban development on the water resources; to legally acquire and protect streamflows in the river; and to obtain public support for streamflow protection. Integrating protection of the riverine environment into general community development is recommended in order to change public negative perceptions about protecting streamflow. Both planning and regulatory measures are necessary for effective protection of streamflows in the Eno River.
Mycorrhizal and Rhizobial Colonization of Genetically Modified and Conventional Soybeans

Field: Agricultural and Biological Sciences (Life Sciences)

ABSTRACT We grew plants of nine soybean varieties, six of which were genetically modified to express transgenic cp4-epsps , in the presence of Bradyrhizobium japonicum and arbuscular mycorrhizal fungi. Mycorrhizal colonization and nodule abundance and mass differed among soybean varieties; however, in no case was variation significantly associated with the genetic modification.
[Survey of preoperative cardiology consultation].

Field: Medicine (Health Sciences)

Cardiology consultations are often requested preoperatively for patients with cardiovascular problems. However, there are frequently differences in the evaluation of preoperative cardiac risks among cardiologists, surgeons and anesthesiologists. In order to obtain possible solutions to this problem, we conducted a survey of preoperative cardiology consultations performed directly by cardiologists. The survey indicates a lack of interaction with anesthesiologists and insufficient information on the surgical procedures and anesthesia for cardiologists to assess compromising cardiac risks. In addition, many cardiologists suggested that exercise tolerance required for surgical procedures should be 7 METs or more for surgical patients.
Preparing and retaining high quality science and mathematics teachers: Research, programs and results

Field: Social Sciences (Social Sciences)

A growing body of research is revealing that the much-publicized lack of sufficient high-quality teachers in U.S. schools is a problem of retention rather than insufficient production, particularly in the case of secondary math and science teachers. Across all subjects, nearly 50% of teachers tend to leave the profession within the first 5 years of beginning teaching, so the attrition problem appears to be one of novice teachers rather than veterans. Furthermore, there is a common assumption in the U.S. that math and science teachers leave at a higher rate than teachers of other subjects because more, and more lucrative, career opportunities are available to individuals with science and math backgrounds. In response to a growing need for highly effective math and science teachers, the Knowles Science Teaching Foundation (KSTF) provides 5-year teaching fellowships to beginning secondary mathematics and science teachers across the United States. In this presentation, I will discuss the structure and rationale of the fellowship in light of national trends in math and science teacher qualifications, effectiveness and retention as well as preliminary results of the fellowship program evaluation research.
Race on TV: Crónica de castas [Chronicle of Castes] (Canal 11, 2014)

Field: Arts and Humanities (Social Sciences)

Chapter 7 enlarges the focus on gender and sexual politics to embrace race and ethnicity. Beginning with a historical account of the complex representation of race in Mexican visual culture (painting, film, and TV), it goes on treat a unique example of a series focusing on that repressed subject. Shot and set in a working class barrio of Mexico City, this series charts the troubled consequences of ethnic mixing in Mexico, presenting little seen (and heard) indigenous characters of different kinds and enlarging its focus to embrace local Jews, Basques, and working-class transvestites. Race, gender, religion, and social class are thus cut and shuffled in this invaluable drama.
CHARACTERIZING THE WEAR PARTICLES OF INTERVERTEBRAL DISC PROSTHESIS AND THEIR BIOLOGICAL RESPONSE

Field: Medicine (Health Sciences)

Prosthetic debris is the leading factor causing prosthetic loosening and requiring revision surgery. Wear debris is formed over time with any prosthesis. Factors determining disc arthroplasty survivability are similar to those for joint replacement technology, and include prosthetic wear, formation of wear debris, and tissue reaction to the wear debris. All wear debris causes a foreign-body reaction that induces an inflammatory response, which results in progressive local bone loss (osteolysis) and possible prosthetic loosening and failure. In this paper are described the nature of particle shape and surface texture, as detected on the particle profile. Detailed surface characteristics of the particles produced during fretting may well be significant in determining their biological effects. Careful processing and analysis of the digitised image enabled both the sizes of micro-projections and their relative numbers to be determined. Such processing of images of a large number of particles generated a considerable amount of data. AutoCAD and MathCAD were used to establish categories the data and to compare the nature of fretting particles generated by UHMWPE and, cobalt-chromium-molybdenum. Although showing a tendency towards a spherical form, all two materials produced different results, with UHMWPE showing the greatest diversity of textures and sizes.
Intelligent prediction of machine tool performance in micro turning using textured inserts

Field: Engineering (Physical Sciences)

Intelligent machine tools can adapt to modifications in the machining environment while performing operations. An intelligent prediction of machine tool condition is an essential aspect in the manufacturing sector of Industry 4.0. Micro components of titanium alloys have huge applications in aerospace, optical and biomedical industries. In this study, machine learning (ML) based models are developed to forecast the performance of a micro-turning machine tool while working with plain and variously patterned textured micro inserts. The micro-turning experiments are performed on Ti6Al4V alloy and the cutting force, surface roughness and tool flank wear are measured for every machining pass. Supervised ML models are trained in order to predict the cutting force, flank wear and surface roughness with cutting parameters and the type of cutting inserts. In the comparison of developed ML models, Extreme Gradient Boost (XGBoost) performs best in prediction with the accuracy of 98.53% and runs in 40.67 milliseconds.
Intravitreal triamcinolone acetonide injection in the acuite phase nonarteritic anterior ischemic optic neuropathy

Field: Medicine (Health Sciences)

Abstract Purpose In nonarteritic anterior ischaemic optic neuropathy (NA‐AION), no treatment has shown to be effective in recovering visual loss in a randomized controlled clinical trial. Oral steroids have been evaluated and small series of IVTA have been reported. The purpose of this study was to analyse the visual outcome in response to a single intravitreal triamcinolone acetonide injection (IVTA) as a treatment for patients with acute NA‐AION. Methods Consecutive patients with either significant visual loss (visual acuity < 0.4) in the first eye or optic nerve head swelling in the second eye due to acute NAION were treated with 4 mg/0.1 mL IVTA. Patient's best‐corrected visual acuity, optical coherence tomography of the retinal nerve fiber layer (RNFL) and visual field were performed before injection, visual acuity was assessed at 1 week, and 2‐12 months after. Results Visual acuity was between 0.08 and 1.0 on inclusion, it improved in 2 eyes (more than 1 line) and remained stable (+/‐ 1 line) in 4 eyes after injection. In the group of eyes reaching (n=2) or maintaining (n=1) a final visual acuity of 1.0, the delay between onset and injection was 7 days or less. In the second group of patients, final visual acuity was between 0.08 and 0.4, the delay between onset was between 2 and 3 weeks. Conclusion The clinical course of these patients suggests that an IVTA may be effective in increasing or maintaining visual acuity following an acute NAION if the treatment is applied within one week. A large randomized controlled study is required to confirm these preliminary data.
Queer theory impossible

Field: Arts and Humanities (Social Sciences)

This essay examines the institutional construction of "queer theory" as a field in the United States and its translation and subsequent failure outside the U.S. Despite presenting itself as a critical field of inquiry, queer theory has been centered in the most privileged institutions in the global North, primarily in the U.S. I investigate how U.S.-centric queer theory has built upon the international division between "theory" and "case," rooted in colonial science and knowledge production, particularly in relation to sexuality and race. To address these issues, I analyze the controversy surrounding the publication and translation of the edited volume, Queer Korea, from Duke University Press's acclaimed Perverse Modernities series, focusing on research ethics and hegemonic whiteness. I argue that this controversy demonstrates how contemporary U.S.-centric queer theory appropriates and capitalizes on the language of "decentering," "provincializing," or "decolonizing" at the expense of marginalized queer lives, struggles, and knowledge outside the U.S.
Pengaruh Kompetensi Dan peluang Sukses Terhadap Pemberdayaan Karyawan Pada Kepemimpinan Transformasional

Field: Business, Management and Accounting (Social Sciences)

This research is intended to analyze the influence of competency and chances of success on the empowerment of employee based on syncretical model of charismatic/ transformational leadership.The respondents consist of 52 employees of PT. Angkasa Pura I Adisutjipto International Airport, Yogyakarta. Questionnaire are used to collect data from the respondents. The instrument of questionnaire from Behling and McFillen are used to measures the variable of competency, chances of success, and empowerment. The data were analized by Multiple Regression Analysis. The result of the study indicate that: (i) competency and chances of success has positive significant influence on the empowerment of employee, (ii). competency has no dominant influence on the empowerment of employee. Keywords: Competency, Chances of Success, Empowerment, Transformational Leadership
Remnant Cholesterol and Its Visit-to-visit Variability Predict Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus: Findings from the ACCORD Cohort

Field: Medicine (Health Sciences)

<p> </p> <p><em><strong>Objective:</strong></em> Remnant cholesterol (remnant-C) predicts atherosclerotic cardiovascular disease, regardless of LDL cholesterol (LDL-C) levels. This study assessed the associations between remnant-C and cardiovascular outcomes in type 2 diabetes mellitus. </p> <p><em><strong>Research design and methods:</strong></em> This post-hoc analysis of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial used patient (type 2 diabetes >3 months) remnant-C and major adverse cardiovascular event (MACE) data from the study database. The associations between remnant-C and MACEs were evaluated using Cox proportional hazards regression analyses. We examined the relative MACE risk in remnant-C versus LDL-C discordant/concordant groups using clinically relevant LDL-C targets by discordance analyses<em>.</em></p> <p><em><strong>Results:</strong></em> The baseline analysis included 10,196 participants, with further visit-to-visit variability analysis including 9650 participants. During follow-up (median, 8.8 years), 1815 (17.8%) patients developed MACEs. After adjusting for traditional cardiovascular risk factors, each 1-SD increase in remnant-C was associated with a 7% higher MACE risk (HR=1.07, 95% CI: 1.02-1.12; P=0.004). In the fully adjusted model, the visit-to-visit remnant-C variability calculated using logSD (HR=1.41, 95% CI: 1.18-1.69, P<0.001) and logARV (HR=1.45, 95% CI: 1.22-1.73, P<0.001) was associated with MACEs. Residual lipid risk (remnant-C ³31 mg/dL) recognized individuals at a higher MACE risk, regardless of LDL-C concentrations. Within each LDL-C subgroup (>100 or ≤100 mg/dL), high baseline remnant-C was associated with a higher MACE risk (HR=1.37, 95% CI: 1.09-1.73; P=0.007; HR=1.22, 95% CI: 1.04-1.41; P=0.015, respectively).</p> <p><em><strong>Conclusions:</strong></em> Remnant-C levels were associated with MACEs in type 2 diabetic patients independent of LDL-C, and visit-to-visit remnant-C variability helped identify those with higher cardiovascular risk.</p>
Estudio sobre el desempeño de las empresas familiares colombianas que cotizan en la bolsa de valores, fren te a las empresas no familiares

Field: Business, Management and Accounting (Social Sciences)

The current study presents a comparison between the\nperformance of 84 family business (FB) and non-family\nbusiness (NFB) traded in the Colombia Stock Exchange.\nData for company performance was collected between\n2003 and 2009. One-way ANOVAs were used to analyze\nthe data and a graphical representation of the confidence\ninterval of the values obtained from the sample. The\nresearch focuses on the Resource Based View Theory of\nthe Firm and is based on the concept of �familiness�. The\nresults suggest that (1) between the FB and NFB were\nno differences in performance, (2) between the majority\nFB (> 50% family owned) and minority FB (>10% and\n<50% owned by family) was found higher profitability\nand indebtedness of the majority FB, and (3) between\nthe FB with boards with less than 50% of relatives and\nthose with higher family presence on the board were no\nsignificant differences. This work validates the outstanding\nperformance of family businesses publicly traded in an\nemerging country like Colombia.
Submerged perspectives: the arts of land and water defense

Field: Arts and Humanities (Social Sciences)

It is through specific genealogies of scholarship on race and coloniality, Indigenous feminisms, and Black feminisms that we can escape the well-rehearsed trope of 'land as body'. Within a comparative hemispheric American studies framework, I consider the centre of struggles over empire and extractivism that show the unravelling of the binary between embodiment and territories. I also consider submerged perspectives and forms of solidarity by those who refuse the material and symbolic infrastructures of racial and extractive capitalism.
Brain circuits in autonomous sensory meridian response and related phenomena

Field: Neuroscience (Life Sciences)

Autonomous sensory meridian response (ASMR) is characterized by a tingling sensation with a feeling of relaxation and a state of flow. We explore the neural underpinnings and comorbidities of ASMR and related phenomena with altered sensory processing. These phenomena include sensory processing sensitivity (SPS), synaesthesia, Alice in Wonderland syndrome and misophonia. The objective of this article is to uncover the shared neural substrates and distinctive features of ASMR and its counterparts. ASMR, SPS and misophonia exhibit common activations in the brain regions associated with social cognition, emotion regulation and empathy. Nevertheless, ASMR responders display reduced connectivity in the salience network (SN), while individuals with SPS exhibit increased connectivity in the SN. Furthermore, ASMR induces relaxation and temporarily reduces symptoms of depression, in contrast to SPS and misophonia, which are linked to depression. These observations lead us to propose that ASMR is a distinct phenomenon owing to its attention dispatch mechanism and its connection with emotion regulation. We suggest that increased activations in the insula, along with reduction in connectivity within the salience and default mode networks in ASMR responders, may account for their experiences of relaxation and flow states. This article is part of the theme issue ‘Sensing and feeling: an integrative approach to sensory processing and emotional experience’.