jimnoneill/paper-to-field-training huggingface dataset:
The Transcriptive Expression and Clinical Significance of nm23H Gene in Human Breast Carcinoma with RT-PCR Method

Field: Medicine (Health Sciences)

To investigate the expression and clinical significance of nm23H gene in human breast carcinoma, breast benign tumor and para carcinoma tissue A semi quantitative reverse transcription polymerase chain reaction was performed to detect the expressions of nm23H 1 and nm23H 2 mRNA in thirty specimens from human breast carcinoma, eight from para carcinoma tissues, night from chronic fibroadenosis and six from fibroadenomas ①The nm23 mRNA gene expression in primary breast cancer tissue with lymph node metastasis was lower than that without lymph node metastasis The nm23H 1 mRNA level in stageⅠ and Ⅱ breast cancer was higher than that in stage Ⅲ ②Multivariate analysis showed a significant relationship between nm23H 1 mRNA expression and lymph node metastasis ③There was no significant relation between nm23H 2 mRNA and tumor size,lymph node status,TNM stage,hormone receptor and menopausal status ④Various degree of expressions for nm23H 1 and nm23H 2 mRNA could be found in fibroadenoma, para carcinoma tissue and chronic fibroadenosis [Conclusion] There is a significantly inverse correlation between nm23H 1 mRNA and lymph node metastasis nm23H 1 appears to play a more important role than nm23H 2 in breast cancer metastasis
A- to B-DNA Transition in AMBER Force Fields and Its Coupling to Sugar Pucker

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The A/B transition is a basic element of DNA conformational change. Because of its involvement in the sensing of the ionic conditions by DNA and in specific protein-DNA interactions, this transition is important for biological functions of DNA. Therefore, accurate modeling of the A/B equilibrium by means of empirical force fields is of utmost interest. In this work, we examine the A/B equilibrium in three AMBER force fields, including the recent bsc1 and OL15 modifications, using much longer MD simulations than attempted before. Special attention is paid to the coupling of the A/B equilibrium with the south/north (S/N) transition of the sugar pucker. We found that none of the tested force fields provided a satisfactory description of the A/B equilibrium because the B-form was predicted to be much too stable and the A-form was predicted to be almost absent even in concentrated trifluoroethanol solutions. Based on comparison with NMR data for duplexes and single nucleosides, we hypothesize that this problem arose from the incorrect description of the S/N equilibrium of sugar pucker, where the south conformation is much too stable, thus stabilizing the B-form. Because neither the A/B equilibrium in duplexes nor the S/N equilibrium in nucleosides was described accurately, further refinements of the AMBER DNA force fields are needed.
A Bayesian-Based Approach to Human Operator Intent Recognition in Remote Mobile Robot Navigation

Field: Computer Science (Physical Sciences)

This paper addresses the problem of human operator intent recognition during teleoperated robot navigation. In this context, recognition of the operator's intended navigational goal, could enable an artificial intelligence (AI) agent to assist the operator in an advanced human-robot interaction framework. We propose a Bayesian Operator Intent Recognition (BOIR) probabilistic method that utilizes: (i) an observation model that fuses information as a weighting combination of multiple observation sources providing geometric information; (ii) a transition model that indicates the evolution of the state; and (iii) an action model, the Active Intent Recognition Model (AIRM), that enables the operator to communicate their explicit intent asynchronously. The proposed method is evaluated in an experiment where operators controlling a remote mobile robot are tasked with navigation and exploration under various scenarios with different map and obstacle layouts. Results demonstrate that BOIR outperforms two related methods from literature in terms of accuracy and uncertainty of the intent recognition.
Welcoming a New Anesthesiology Editor

Field: Medicine (Health Sciences)

Special Announcement| July 2022 Welcoming a New Anesthesiology Editor Anesthesiology July 2022, Vol. 137, 3. https://doi.org/10.1097/ALN.0000000000004280 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Search Site Citation Welcoming a New Anesthesiology Editor. Anesthesiology 2022; 137:3 doi: https://doi.org/10.1097/ALN.0000000000004280 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll PublicationsAnesthesiology Search Advanced Search Topics: analgesics, analgesics, non-narcotic, assessment scales, biological markers, chronic pain, infections, internship and residency, laboratory, music, neuroscience Kristin L. Schreiber, M.D., Ph.D., is the newest editor for Anesthesiology. Dr. Schreiber is an Associate Professor at Harvard Medical School and Associate Vice Chair of Research in the Department of Anesthesiology, Perioperative, and Pain Medicine at Brigham and Women’s Hospital in Boston. She completed her M.D. and a Ph.D. in neuroscience at the University of Minnesota, investigating reciprocal neural-immune interactions involved in infection and the development of persistent pain. She completed residency training at the University of Pittsburgh and fellowship at Brigham and Women’s Hospital, where she practices clinically as a regional anesthesiologist. Her research program investigates the development of chronic pain after surgical injury, using psychosocial and psychophysical assessment tools, in addition to biomarkers, clinical characteristics, and sociodemographics, to predict who is most at risk. Her perioperative interventional studies incorporate this dense biopsychosocial assessment of individual patients into their design, to allow more nuanced assessment of differential... You do not currently have access to this content.
In silico analysis of glycosylation pattern in 5th-6threpeat sequence of reelin glycoprotein

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Reelin is an extracellular matrix glycoprotein that plays a key role in cortical development, maturation, synaptic plasticity, and memory formation in the adult mammalian brain. Glycosylation is a significant post- and co-translational modification of proteins. Although glycosylation contributes to the characteristic of proteins from their production to molecular interactions, the knowledge about the glycosylation pattern of reelin is very limited. In this study, we aimed to predict the potential glycosylation pattern of the 5th-6th repeat of central reelin fragment that responsible for their signaling, by using in silico methods. We found that the predicted glycosylation pattern of the 5th-6th repeat of human reelin was highly conserved between vertebrate species. However, this conservation was not observed in analyzed invertebrates. For the first time, we described the sites of glycosylation at a three-dimensional protein structure in human reelin. Because the sites were very closed to EGF-like repeats and receptor binding sites, they could contribute the interaction with a partner of reelin in addition to the effect of thermostability to protein. Many of the residues related glycosylation were also conserved in analyzed species. These findings may guide biochemical, genetic, and glycobiology base on further experiments about reelin glycosylation. The understanding of reelin glycosylation might change the point of view of treatment for many pathological conditions in neurodegenerative diseases such as Alzheimer's disease. Communicated by Ramaswamy H. Sarma.
ANALOGIES BETWEEN THE AQUEOUS HUMOR AND THE CEREBROSPINAL FLUID

Field: Medicine (Health Sciences)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anatomical and Physiological Effects of Spent-Engine Oil on Two Varieties of Abelmoschus esculentus (L.) Moench. from Malvaceae

Field: Agricultural and Biological Sciences (Life Sciences)

The effect of different levels of spent engine oil application on germination, survival, growth, leaf anatomy, yield, nutrient content and heavy metals uptake of okra (Abelmoschus esculentus – ‘Clemson’ spineless variety and ‘OLA 3 Local’ variety) was assessed in the present study. Completely randomized design was used with five treatment levels of spent engine oil at 0 ml (control), 50 ml, 100 ml, 150 ml and 200 ml applied to 5 kg of soil. Data on germination, seedling survival, growth, chlorophyll nutrient and heavy metal content, as well as leaf epidermal features collected from the study were subjected to Statistical Package for Social Sciences (SPSS) analyses. Spent engine oil at 200 ml per pot significantly (P < 0.05) delayed seed germination for 4 days and reduced germination percentage by approximately 24% compared to the control. Plant height, number of leaves, leaf area, chlorophyll A, B and stomata area were reduced by 21.33-72.89%; number and dry weight of fruits were reduced by 67.4-13.58%. Number of stomata was increased on the adaxial surface by 57.73% and on the abaxial surface by 34.99%. Na, K, Cr, Cd and Fe contents increased by 0.0178-6.2698 mg/kg-1. The present study has shown that plant constituents and anatomy can be influenced by spent oil contamination. Contamination of soil with spent engine oil therefore should be avoided in order to ensure sustainable crop plant productivity and to reduce the risk of heavy metals toxicity for human beings.
Switching properties of SrRuO 3 /Pb(Zr 0.4 Ti 0.6 )O 3 /SrRuO 3 capacitor grown on Cu-coated Si substrate measured at various temperatures

Field: Materials Science (Physical Sciences)

SrRuO3(SRO)/Ni-Al/Cu/Ni-Al/SiO2/Si heterostructures annealed at various temperatures are found to remain intact after annealing. Moreover, a SRO/Pb(Zr0.4Ti0.6)O3 (PZT)/SRO capacitor is grown on a Ni-Al/Cu/Ni-Al/SiO2/Si heterostructure, which is tested up to to investigate the reliability of the memory capacitor. It is found that besides the good fatigue resistance and retention characteristic, the capacitor, measured at 5 V and room temperature, possesses a large remnant polarization of and a small coercive voltage of 0.83 V, respectively. Its dominant leakage current behavior satisfies the space-charge?limited conduction at various temperatures. Very clear interfaces can be observed from the cross-sectional images of transmission electron microscopy, indicating that the Ni-Al film can be used as a diffusion barrier layer for copper metallization as well as a conducting barrier layer between copper and oxide layer.
Arbitrage opportunities for stocks listed on the SGX and their underlying American depository receipts.

Field: Economics, Econometrics and Finance (Social Sciences)

There has been an increasing interest in dual listing for SGX listed stocks in US markets, especially in the form of American Depositary Receipts (ADRs). Many investors are exploring the possibility of an arbitrage opportunity between the stocks listed in the Singapore markets and their underlying ADRs in the US markets.
Organizations: A Typology of HRD Interventions

Field: Business, Management and Accounting (Social Sciences)

A considerable body of research exists on corporate social responsibility (CSR) and corporate sustainability (CS). However, there is significantly less on the influence of employees on the adoption of CSR and CS initiatives. Given the centrality of employees as stakeholders in CSR/CS adoption, it is important to understand how barriers at individual, organizational, and institutional levels of analysis influence the adoption of CSR/CS initiatives. An understanding of these barriers will illuminate the potential contribution of human resource development (HRD) to their removal. HRD has a major role to play in changing employee behavior and organizational values and there are significant affinities between HRD and CSR/CS concerning behavior and change. This article discusses a typology of HRD interventions that may be used to address barriers to the implementation of CSR/CS initiatives. Keywords corporate social responsibility, corporate sustainability, individual barriers Corporate social responsibility (CSR) and corporate sustainability (CS) are now widely accepted concepts in the academic world, and are emerging as key variables in the global business environment in the bid to achieve competitive advantage (Montiel, 2008; Orlitzky, Schmidt, &amp; Rynes, 2003). In an international survey on corporate at PENNSYLVANIA STATE UNIV on May 10, 2016adh.sagepub.comDownloaded from
Yeni Mehmed reisler gelsin (New Mehmed Pashas should come)

Field: Arts and Humanities (Social Sciences)

Bugunku yazimizda Tayland’in bilinmeyen Fatihi, fetih ruhunu, ozgurlugune duskun Tayland halkinin Krali P’rajai’ye (1534-1549) asilayan Osmanli deniz Amirali Hayreddin Mehmet Reis’ten bahsedecegim. 16. asirda Buyuk Okyanusa adim atan Osmanli donanmasi dunyanin dort bir kosesine oldugu gibi Endonezya’nin ozellikle Sumatra adasina da ugrayarak bir cok Turk’u buralara birakarak Islam’in yayilmasina onculuk ettiler.
Differences between semi-quantitative and quantitative approaches for probabilistic assessment of technological risks

Field: Decision Sciences (Social Sciences)

The aim of this paper is to compare the probabilistic approach based on fault trees and event trees, to an approach called "semi-quantitative" as presented by the guide Omega 10 (INERIS, 2008), for the industrial risk management. A brief presentation of the ''classical'' probabilistic risk assessment as well as the ''semi-quantitative'' approach is proposed. Then, a case study is detailed to illustrate and compare their use. This case study focuses on a low pressure separator (water/gas/condensate) for which scenarios have been identified around the undesired event "gas leak due to overpressure in the separator.'' The system includes a control loop and the following safety barriers: an alarm with operator actions, a safety instrumented system, two safety relief valves, and a blast-proof partition. This case study therefore represents a relatively conventional system in the industry. Regarding to the implementation of the two approaches, the assessment according to the Omega 10 guide is easier and faster. In terms of results, differences can be observed, up to a factor 10.
UX DESIGN EVALUATION OF AN AUGMENTED REALITY SYSTEM FOR HUMAN PHYSICAL TRAINING

Field: Computer Science (Physical Sciences)

Technology advancements has enabled dance to be learnt without mirrors or real dance trainer. Distinctive benefits has been contributed by Augmented Reality (AR) technology. Dance trainers are focusing upon implementing dance analysis systems to enhance dance trainee’s artistic skills. AR technology presents new user experience (UX) for learning, instructing, developing and accessing physical dance movements as well as provides scope to expand dance resources and rediscover the learning process. In this research work, we present a novel human physical training system i.e. dance training and analysis that could help individuals in learning selected dance styles which ignites motivation, matches dance steps/body postures and analyzes the performance. This study explored quantitative data by means of statistical tests validation with participants in using the phyisical training system that has facilitated in testing the dance body postures and steps. The work also adopted the user experience (UEQ) questionnaire to perform the UX evaluation. The outcome revealed favaroble results indicating the measurement score of the UEQ six scales to be in the positive range.
Non-linear waves in a non-uniform plasma

Field: Physics and Astronomy (Physical Sciences)

The work of Butler & Gribben (1968) on a general formulation ofthe problem of non-linear waves in non-uniform plasmas is extended. The particular case treated in Butler & Gribben, § 6, is discussed again (the distribution functions f s and electrostatic potential depend only on one space co-ordinate, that in the direction of propagation of the wave, the wave is slowly varying only with respect to this co-ordinate and time, the magnetic field vanishes and relativistic effects are negligible). Conditions necessary to avoid secular terms in the solutions of the Vlasov and Poisson equations are rederived, but without resorting to assumed series expansions in e , the perturbation parameter describing the non-uniformity, for the dependent variables, and using a different notation which simplifies and retains the symmetry of the equations. The corresponding general boundary condition, to be satisfied by f s innergy space at the boundary of the trapped particle region, is also derived. Particular attention is devoted to the Vlasov equation, and the derived general result is used to obtain the appropriate necessary condition from this equation, correct to O(ε) . This shows that, unlike the leading-order theory, at the next stage an extra length scale appears in the equations, which would be needed if e.g. the theory were to be used to discuss shock waves. It is argued that this result, taken with the mixing process described in Butler & Gribben (which supplies a mechanism for the formation of shocks), appears to place the theory at least on as satisfactory a level as the Navier-Stokes theory for the discussion of shock wave structures. Another aspect of the analysis is the comparison with the Whitham (1965 a ) averaging method for treating the propagation of non-linear waves in other fields. Similar features are pointed out, and it seems likely that the averaging method is equivalent to the leading-order theory. It is thought that the present approach might prove to be useful in other wave problems.
ST-segment elevation myocardial infarction

Field: Medicine (Health Sciences)

Acute myocardial infarction with ST-segment elevation is a common and dramatic manifestation of coronary artery disease. It is caused by the rupture of an atherosclerotic plaque in a coronary artery, leading to its total thrombotic occlusion and resultant ischaemia and necrosis of downstream myocardium. The diagnosis of ST-segment elevation myocardial infarction is based on a syndrome of ischaemic chest pain symptoms, associated with typical ST-segment elevation on the electrocardiogram and an eventual rise in biomarkers of myocardial necrosis. The treatment of ST-segment elevation myocardial infarction is focused on re-establishing blood flow in the coronary artery involved, preferably by percutaneous coronary intervention, or by pharmacological thrombolysis in the case of expected lengthy time delays or lack of availability of facilities. Early mortality from ST-segment elevation myocardial infarction can be attributed to the sequelae or complications of myocardial ischaemia, or complications related to therapy. The former include arrhythmias (such as ventricular tachycardia or fibrillation), mechanical complications (such as ventricular free wall, septal, and mitral chordal rupture), and pump failure leading to cardiogenic shock. The latter includes haemorrhagic complications and coronary stent thrombosis. Given that myocardial necrosis is a critically time-dependent process, the organization of an ST-segment elevation myocardial infarction care system and adherence to the latest clinical trial evidence and guidelines are crucial to ensure that patients are treated in an optimal manner.
In vitro expression of the 50-kDa and 30-kDa fragments of the P97 adhesin of Mycoplasma hyopneumoniae in Escherichia coli and their use for serodiagnosis.

Field: Veterinary (Health Sciences)

This article reports the cloning and expression of 2 fragments of the P97 adhesin of Mycoplasma hyopneumoniae for use in serodiagnosis: a 50-kDa fragment (including the N-terminal cleavage site) and a 30-kDa fragment (including the C-terminal R1 and R2 repeats, which are essential for adherence). The genes encoding the fragments were amplified, cloned, and expressed in the Escherichia coli expression system BL21 (DE3)pLysS. Antiserum against the purified recombinant proteins reacted with the mycoplasmal 97-kDa intact protein and the 66-kDa major cleavage fragment, confirming that both cloned fragments could induce antigen-specific antibodies in mice. Of 70 serum samples from nonvaccinated pigs, 26 (37%) were seropositive when the 30-kDa fragment was used as an antigen for enzyme-linked immunosorbent assay, suggesting that natural mycoplasmal infection is quite common in Korea. However, only 4 samples were seropositive when the 50-kDa fragment was used; this fragment was therefore deemed unsuitable for serodiagnosis. The 30-kDa fragment protein might be useful for measuring antibody response to vaccination and for detecting mycoplasmal infection.
The role of ferroptosis in radiotherapy and combination therapy for head and neck squamous cell carcinoma (Review)

Field: Medicine (Health Sciences)

Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive, heterogeneous tumour usually caused by alcohol and tobacco consumption, making it one of the most common malignancies worldwide. Despite the fact that various therapeutic approaches such as surgery, radiation therapy (RT), chemotherapy (CT) and targeted therapy have been widely used for HNSCC in recent years, its recurrence rate and mortality rate remain high. RT is the standard treatment choice for HNSCC, which induces reactive oxygen species production and causes oxidative stress, ultimately leading to tumour cell death. CT is a widely recognized form of cancer treatment that treats a variety of cancers by eliminating cancer cells and preventing them from reproducing. Immune checkpoint inhibitor and epidermal growth factor receptor are important in the treatment of recurrent or metastatic HNSCC. Iron death, a type of cell death regulated by peroxidative damage to phospholipids containing polyunsaturated fatty acids in cell membranes, has been found to be a relevant death response triggered by tumour RT in recent years. In the present review, an overview of the current knowledge on RT and combination therapy and iron death in HNSCC was provided, the mechanisms by which RT induces iron death in tumour cells were summarized, and therapeutic strategies to target iron death in HNSCC were explored. The current review provided important information for future studies of iron death in the treatment of HNSCC.