jimnoneill/paper-to-field-training huggingface dataset:
Role of α5β1 and αvβ3 Integrins on Smooth Muscle Cell Spreading and Migration in Fibrin Gels

Field: Medicine (Health Sciences)

Summary Fibrin is found at sites of vascular injury and is one of the major matrix ligands for β3 integrins. Blocking the β3 integrin on smooth muscle cell is hypothesized as a potential target to prevent restenosis because it could inhibit cell attachment and migration into fibrin provisional matrix. Human aortic smooth muscle cells (HNB18E6E7) spread stably in plasma gels within 24 h. Cell spreading was dramatically blocked by simultaneous use of α5β1 and αvβ3 integrin antibodies (P <0.0001), however, blocking of either integrin alone failed to inhibit spreading. GPenGRGDSPCA, which has been considered a specific αvβ3 antagonist, inhibited spreading at 500 µM, suggesting that the peptide blocked both α5β1 and αvβ3. Similarly, invasive migration into fibrin gels was blocked by simultaneous use of both α5β1 and αvβ3 antibodies, however, blocking of either integrin alone failed to effect cell migration. Another migration assay using transwell indicated similar results. In conclusion, both α5β1 and αvβ3 integrins are responsible for smooth muscle cell spreading and migration into fibrin gels. These data suggest that blocking β3 integrin alone would not affect smooth muscle cell interaction with fibrin.
Halveti Şeyhlerinden Ünsî Hasan'ın Dîvân-ı İlâhiyât Adlı Eseri

Field: Arts and Humanities (Social Sciences)

Hasan Ünsî was a Sufi belonging to the Halvatiyya-i Sha'bâniyya school of Sufism who lived between the XVII-XVIII centuries, during the reigns of Mehmed IV, Ahmed II, Mustafa II and Ahmed III, and who met directly or indirectly with Baltacı Mehmed and Çorlulu Ali Paşa. He was raised by Sheikh Ali Atvel, one of the most competent Sufis of the XVIIth century, nicknamed Karabaş-ı Velî, who resided in Üsküdar, and sent to Istanbul. One of the main branches of Halvatiyya, one of the most important professions in the history of Sufism, which emerged in Anatolia in the XVIth century, is the Sha'bâniyya branch. This branch was established by Sha'bân-ı Velî (d. 1569). Because both the founder Pîr and the saints belonging to the later lineage had ideas based on divine love and the unity of the body, enjoyed halvah and led ascetic lives, the information about the lineage and the ascetics in this profession -as in Mevleviism and Bektashism- has not been transferred to written sources much. This being the case, the importance of written documents increases even more when researching the place of the members of the said tradition in our cultural history. One of the most important features of this dīvān, written by Hasan Ünsî, who came to teach almost a century after the death of Sha'bān al-Walī, the founder of the movement, is that it will make an important contribution to the research on ‘Sha'bāniyya’. In this study, the poet's thoughts about his love and wisdom are outlined and a contribution to this field is presented. Keywords: Halwatiyya, Shabaniyya, Sufism, divan, textual reproduction.
Case report Fatal thrombosis with activated factor VII in a paediatric patient on extracorporeal membrane oxygenation

Field: Medicine (Health Sciences)

Bleeding remains a potential complication for patients requiring extracorporeal life support systems. Recombinant activated factor VII (rFVIIa) is one of the drugs used in controlling bleeding. Its use is generally found to be safe. We report a paediatric patient who developed fatal thrombosis with the use of rFVIIa whilst on extracorporeal membrane oxygenation and discuss the possible factors that lead to fatal thrombosis. Crown Copyright # 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
Short Video Viewing, and Not Sedentary Time, Is Associated with Overweightness/Obesity among Chinese Women

Field: Health Professions (Health Sciences)

Previous studies have found that the relationship between sedentary time (ST) and overweightness/obesity is unclear. The association between sedentary behavior and overweightness/obesity may depend on the type of sedentary behavior engaged in. Nowadays, in older Chinese adults, especially females, short video viewing (SVV) is the most popular leisure sedentary behavior. However, the association between SVV and overweightness/obesity remains to be determined. This study aimed to examine the associations between ST and SVV and overweightness/obesity in Chinese community-dwelling older women. A cross-sectional analysis of baseline data from the Physical Activity and Health in Older Women Study was carried out in this study. A total of 1105 older Chinese women aged 60–70 years were included. SVV was estimated using a self-reported questionnaire, and ST was objectively measured using a tri-axial accelerometer. Overweightness/obesity indicators, including body fat ratio (BFR), fat mass (FM), visceral fat mass (VFM), subcutaneous fat mass (SFM), trunk fat mass (TFM), and limb fat mass (LFM), were assessed using multi-frequency bioimpedance analysis. The covariates included socio-demographic data and a range of health-related factors. Multiple linear regression analyses were used to assess the association between ST and SVV and overweightness/obesity. ST was significantly positively associated with all indicators of overweightness/obesity; however, the associations disappeared after adjusting for moderate-to-vigorous-intensity physical activity (MVPA). A higher SVV time was associated with a higher body mass index (BMI) (β = 0.19, 95% confidence interval (CI): 0.05 to 0.32), BFR (β = 0.31, 95% CI: 0.07 to 0.56), FM (β = 0.33, 95% CI: 0.04 to 0.61), VFM (β = 0.09, 95% CI: 0.01 to 0.16), SFM (β = 0.24, 95% CI: 0.03 to 0.45), TFM (β = 0.21, 95% CI: 0.04 to 0.39), and LFM (β = 0.11, 95% CI: 0.00 to 0.23) in the fully adjusted models. Compared with non-food short videos, short food videos had a greater effect on overweightness/obesity. SVV was an independent risk factor for overweightness/obesity. A reduction in SVV (especially the food category) rather than ST might be an effective way to prevent overweightness/obesity when incorporated in future public health policy formulations.
Global Policy to Reduce the Incidence of Infection Spreading in Non-Vaccinated Healthcare Workers: A Literature Review

Field: Health Professions (Health Sciences)

Healthcare workers (HCWs) are at increased risk of SARS-CoV-2 infection because of their occupational exposure. Moreover, they can be a vehicle for the virus transmission among patients. The vaccination of healthcare personnel against COVID-19 is crucial in fighting the spread of SARS-CoV-2 infection, together with strict sanitary procedures that aim to limit the risk of contagion. Unfortunately, even if COVID-19 vaccination has been proved one of the most effective tools for protecting against COVID-19, many healthcare professionals are not yet vaccinated. The aim of the current review is to contribute to identifying an effective strategy for COVID-19 prevention especially among non-vaccinated HCWs. In this review, we collected the most recent and relevant findings from literature on the protection of unvaccinated HCWs, identifying three types of measures as principal actions to protect those operators: addressing vaccine hesitancy, improving non-pharmaceutical interventions and promoting actions at personal level (respiratory hygiene, hand hygiene and use of PPE). All these interventions are very effective in preventing contagion, if well respected and conducted; nevertheless, it is essential to promote vaccination, as it is the most effective measure.
Microcolon of prematurity: a form of functional obstruction

Field: Medicine (Health Sciences)

Six premature infants (birth weights 920-1320 g) developed marked abdominal distension after birth, and contrast enema examination showed a microcolon. Four of the six were born to mothers with toxemia who received magnesium sulfate. Bilious emesis was absent in all six, despite marked distension and failure to pass meconium. None of the patients had aganglionosis or cystic fibrosis; five of six were followed without surgery and recovered spontaneously. The sixth had perforation 8 hr after contrast enema and required bowel diversion; this infant also survived. This appears to be an equivalent form in small premature infants of the "small-left-colon syndrome" seen in term infants. Surgery should be reserved for complications; it is not necessarily indicated by the finding of a microcolon in such patients.
Carmelites and Camaldules

Field: Arts and Humanities (Social Sciences)

Journal Article Carmelites and Camaldules Get access F. P. Barnard F. P. Barnard Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CLVII, Issue jul20, 20 July 1929, Page 45, https://doi.org/10.1093/nq/CLVII.jul20.45c Published: 20 July 1929
Vitamin D: to test or not to test

Field: Health Professions (Health Sciences)

Vitamin D deficiency has recently been linked to many chronic diseases such as MS (multiple sclerosis), cancer, rheumatoid arthritis, and diabetes. It has been a topic of debate among healthcare providers on whether or not it is beneficial to test and treat patients who have vitamin D deficiency. This paper looks at the potential mechanism of vitamin D in these disease processes and evaluates the various studies in the literature focusing on vitamin D levels and chronic diseases. This paper concludes by recommending that physicians in Allegheny County, PA, test all their adult patients for vitamin D deficiency, especially during the winter months. Vitamin D deficiency and the link to chronic disease have vast significance in the field of public health both in Allegheny County, PA, and nationwide.
Chapter 14 – Sentencing the Toronto 18: Lessons from Then, Lessons for Now

Field: Social Sciences (Social Sciences)

Eleven of the Toronto 18 were eventually charged and tried for terrorism offences. All of them were found guilty and received various lengthy custodial sentences. This chapter considers the enduring importance of these ground-breaking sentencing decisions, including what they have meant for future cases in terms of the length of sentence, how aggravating and mitigating factors are to be considered in the context of terrorism offences, and how the fundamental principle of sentencing is to be conceived in cases of terrorism. It finds that the Toronto 18 sentencing decisions have had lasting importance on subsequent terrorism sentencing decisions, especially since they were amongst the very first and thus, precedent setting terrorism sentencing decisions, there were so many of them relative — even now — to the total number of terrorism cases in Canada, and their logic has been adopted by subsequent judges. But this judicial logic also comes under scrutiny.While each sentencing decision was tailored to the individual, varied in length and analysis, and clearly gave longer sentences for the lead actors, they also diverged in approach from the usual application of the “fundamental principle.” Instead, the analysis of terrorism offences in the Toronto 18 sentencing decisions was often portrayed through the broader lens of terrorism and the threat it poses conceptually; the result was a downplaying of individuality, which in turn caused certain fundamental mitigating considerations – such as youth and prospects for rehabilitation – to be turned into neutral, or even aggravating, factors. The result seemed to skew the normal balancing of individual moral culpability with the seriousness of the offence (the fundamental principle) towards the latter consideration, with a view to elevating denunciation and deterrence as the preeminent sentencing goals in terrorism cases.
Riesengesichter jüdischer Vergeltung

Field: Arts and Humanities (Social Sciences)

This diploma thesis examines the controversial nature of Quentin Tarantino’s Inglourious Basterds. The thesis argues that the critical reception of the film is in line with the tradition of fictional narratives of the Shoah. Tarantino’s depiction of Jews as well as women differs from the conventionalized manners of representation in classical Hollywood cinema. The brutal behavior of the eponymous Basterds, a team of Jewish-American guerilla fighters, as well as that of the Female Avenger Shosanna Dreyfus, the film’s Jewish-French heroine, does not meet the expectations of the audience. Whereas classical cinema tends to depict Jews as passive and helpless victims fully dependent on the mercy of the perpetrators, Tarantino’s visualization of Jewishness can be read as a counter-image to this mode of representation. The Jewish protagonists empower themselves and rebel against the picture of passive victimhood. Shosanna’s final act of vengeance and the Basterds’ “Nazi Killin’ business” challenge the image of the woman and Jew as the Other. As a big-budget Hollywood-blockbuster, Inglourious Basterds does not hide its artificial status and brings back to mind the Jewish resistance during the Shoah, which was marginalized and overlooked in public history.
Allostery and applications of the lac repressor

Field: Medicine (Health Sciences)

The majority of patients with metastatic germ cell tumors can be cured with currently available poly-chemotherapy. Based on presenting criteria three prognostic groups can be discerned. In patients with a good prognosis (> 90% probability of 5-year survival) attempts have been made to diminish the dose of the active compounds in the BEP regimen. The omission of bleomycin cannot be recommended on presently available data; and a total dose of at least 240 mg seems appropriate. Platinum at a dose intensity below 75 mg/m2/3 weeks compromised efficacy and the recommended dose is 100 mg/m2. A true comparison between the two most frequently used etoposide doses has not been performed. Based on the available literature etoposide should be given in doses of at least 360 mg/m2/cycle when four courses are given and 500 mg/m2/cycle when three courses are given. For intermediate and high-risk patients alternating, accelerated and high-dose chemotherapy can be considered. None of the alternating and accelerated regimens has a proven advantage in randomized trials and they remain investigational. The addition of hematopoietic growth factors permits a higher dose intensity of BEP/EP and BOP/VIP; although to date there is no proven impact on outcome. The application of high-dose chemotherapy for one to four courses is feasible with the support of both hematopoietic growth factors and autologous bone marrow or peripheral stem cells. In true chemotherapy-resistant disease the value of this approach seems limited. Its role in patients with a first relapse should be further explored. The approach of high-dose chemotherapy in first line for patients with poor prognostic features should preferentially be investigated in a randomized fashion, but this will require extensive international collaboration in view of the low incidence and the expected advantage of the approach.
Effect of Core Materials on the Dimensional Accuracy of Casts Made of Two Different Silicone Impression Materials: An Experimental Study

Field: Dentistry (Health Sciences)

A BSTRACT Background and Aim: Dimensional accuracy of impressions is crucial to the quality of fixed restorations. This accuracy can be highly affected by the type of core and impression materials. This study aimed to assess the effect of different core materials on dimensional accuracy of two silicone impression materials. Materials and Methods: In this in vitro study, three master core models were fabricated of amalgam, composite resin, and nickel–chromium. Of each model, 30 impressions were taken; 15 with additional and 15 with condensational silicone impression material. The accuracy of impressions of the three core materials was assessed by measuring two linear dimensions and one vertical dimension on the stone casts. Statistical Analysis: Data were analyzed with two-way analysis of variance and Scheffe post hoc test (α = 0.05). Results: Accuracy of the three measured dimensions was significantly affected by both the impression and core materials ( P < 0.05). Additional silicone was significantly more accurate in linear dimensions, and impressions of the amalgam core were significantly more accurate than other cores in linear dimensions. Conclusion: Additional silicone impression material had more detail reproduction, and the impressions of amalgam core were more accurate than the composite and nickel–chromium core materials.
Does random practice impair motor skill consolidation

Field: Neuroscience (Life Sciences)

Consolidation processes taking place between practice sessions are known to stabilize motor skills and improve performance without further practice (Trempe & Proteau, 2012). The recent consolidation theory also suggests that motor skills should be practiced in isolation from one another to minimize interference between the skills and optimize learning (Walker et al., 2003). This suggestion however challenges one of the most prominent theories of the 20 th century suggesting that random practice (i.e., practicing two different skills alternatively during the same practice session) leads to better learning than blocked practice (i.e., practicing two different motor skills separately; Shea & Morgan, 1979). To address this discrepancy, we used a finger-sequence task in which participants had to learn in the same practice session two different sequences of finger movements. Participants either practiced the sequences in alternate order (random practice group) or separately (blocked practice group) before being retested 24 hours later. A control group also practiced only one sequence. As in previous reports, consolidation effects were measured by comparing the number of successfully completed sequences at the end of the practice session with the number of successfully completed sequences during the retention test (Walker et al., 2003). Our results revealed that the blocked practice schedule led participants to perform both sequences significantly faster during the retention test, whereas the random practice schedule led to a speed improvement of the first sequence only. Thus, random practice impaired the consolidation of the second sequence.
Research on Virtual-Actual Combination Experimental Teaching Platform of Virtual Simulation Experiment Center Construction Practice—Taking Mechanical Foundation and Textile Equipment Experiment Center as an Example

Field: Engineering (Physical Sciences)

This article explains the significance of "virtual-actual combination" teaching mode of virtual simulation experiment, construction content of "virtual-actual combination" teaching platform on the basis of " virtual simulation experiment teaching center of machinery foundation and textile equipment design" construction work in school of mechanical engineering in Tianjin Polytechnic University, taking dynamic performance analysis simulation module of high speed and mixed-phase device as example, the implementation effect of "virtual-actual combination" is expounded, and the "virtual-actual combination" teaching platform construction of machinery foundation and textile equipment virtual simulation experiment center are prospected.
Evaluation and epigenetic impact of B12, vitamin D, folic acid and anemia in Hashimoto's thyroiditis: a clinical and molecular docking study

Field: Medicine (Health Sciences)

Aims: Our approach in this study is to investigate the collective effect of various parameters, including vitamin B12 (B12), vitamin D (Vit-D), folic acid, and iron deficiency, on Hashimoto's thyroiditis (HT) disease. This differs from existing literature that has examined these parameters individually. Methods: The study evaluated age, gender, thyroid stimulating hormone (TSH), free-T4 (FT4), free-T3 (FT3), Vit-D levels, as well as autoantibodies against thyroid peroxidase (anti-TPO) and anti-tyroglobulin iron (anti-TG) levels, ferritin, B12, and folic acid parameters in a total of 30 HT patients and 37 non-HT patients. These parameters were assessed by analyzing the patients' routine blood test results using automated analysis methods. Results: A negative correlation was found between the blood, Vit-D level and anti-TG (as the vit-D value increases, the anti-TG decreases) (r=-0.417; p=0.001; p
Using style to understand descriptions of software architecture

Field: Computer Science (Physical Sciences)

The software architecture of most systems is described informally and diagrammatically. In order for these descriptions to be meaningful at all, figures are understood by interpreting the boxes and lines in specific, conventionalized ways[5]. The imprecision of these interpretations has a number of limitations. In this paper we consider these conventionalized interpretations as architectural styles and provide a formal framework for their uniform definition. In addition to providing a template for precisely defining new architectural styles, this framework allows for the proof that the notational constraints on a style are sufficient to guarantee the meanings of all described systems and provides a unified semantic base through which different stylistic interpretations can be compared.
The Frankenstein Notebooks

Field: Arts and Humanities (Social Sciences)

Mary Shelley's Frankenstein is arguably the best known work of the English Romantic period. First published in 1996, this edition of The Frankenstein Notebooks contains not only facsimiles and transcriptions of all of surviving manuscripts related to the novel and a corrected, critical text of Frankenstein (or The Modern Prometheus) but also a full range of factual information, drawn from Shelley's and William Godwin's letters and journals, from newspaper ads of the day, and from other available scholarship about the conception, gestation, and birth of Mary Shelley's monster. This two volume set contains a wealth of information vital to the creation and reception of Frankenstein. It will enable scholars, critics and students to see for themselves the exact extent of P. B. Shelley's editorial contributions and trace the artistic and ideological development of the novel at various stages in its formation. It will also enable the reader to explore the text itself to test and evaluate their own theses. Part one contains the draft notebook A, which was written between August or September and December 1816. This set will be of keen interest to those studying Frankenstein, the Romantics and 19th century literature.
Remittance and Economic Growth Nexus in Nigeria: Does Financial Sector Development Play a Critical Role?

Field: Economics, Econometrics and Finance (Social Sciences)

The purpose of the study was to examine the relationship between remittances, financial sector development, and economic growth in Nigeria over the period 1981 to 2017. The study used the autoregressive distributed lag (ARDL) model to analyze the long-run and short-run relationships between the variables. The outcome of the study revealed that the variables are bound together in the long-run. The results also showed that remittances have a negative and significant effect on economic growth both in the long-run and short-run. The study also established that financial sector development has a negative and significant impact on economic growth both in the long-run and short-run. Further, the study confirmed the existence of complementarity between remittances and financial sector development in influencing economic growth. In addition, study revealed that inflation has a negative and significant effect on economic growth both in the long-run and short-run. The findings of the study showed that trade openness, government expenditure, and population growth have no significant impact on economic growth both in the long-run and short-run.