Immunity to Schistosomes: Advances and Prospects

Field: Immunology and Microbiology (Life Sciences)

Editorials1 October 1979Immunity to Schistosomes: Advances and ProspectsJOHN R. DAVID, M.D., ANTHONY E. BUTTERWORTH, PH.D.JOHN R. DAVID, M.D.Search for more papers by this author, ANTHONY E. BUTTERWORTH, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-4-641 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUntil recently, immunology has had relatively little to offer for the control of schistosomiasis, a disease that already affects more than 200 million people and which is, because of the widespread development of irrigation schemes, an increasing public health problem. On the one hand conventional parasitologic diagnostic techniques have proved more sensitive and specific than immunologic methods using crude parasite antigens. On the other hand, no vaccines are available, and control has rested largely on standard methods of chemotherapy, mollusciciding, and water engineering and sanitation. In both diagnosis and control, there is now room for new immunologic approaches.The problems...References1. BOUT D, DUGIMONT J, FARAG H, and CAPRON A Immunodiagnosis of human parasitic diseases by ELISA. In: FELDMANN G, ed. First International Symposium on Immunoenzymatic Techniques, INSERM Symposium No. 2. Amsterdam: North-Holland Publishing Company; 1976:175-82. Google Scholar2. KOHLER G and MILSTEIN C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975;256:495-7. CrossrefMedlineGoogle Scholar3. TAYLOR M, JAMES E, NELSON G, BICKLE Q, DUNNE D, and WEBBE G. Immunisation of sheep against Schistosoma mattheei using either irradiated cercariae or irradiated schistosomula. J Helminthol. 1976;50:1-9. CrossrefMedlineGoogle Scholar4. SMITHERS S and TERRY R. 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Brigham Hospital Harvard Medical School Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiagnosis and treatment of schistosomiasis in children in the era of intensified controlSchistosomiasis and Renal TransplantationGenito-urinary Schistosomiasis (Bilharziasis). Part 1 1 October 1979Volume 91, Issue 4 Page: 641-643 Keywords Antigens Chemotherapy Diagnostic techniques Immunity Immunology Prevention, policy, and public health Sanitation Schistosomiasis Vaccines ePublished: 1 December 2008 Issue Published: 1 October 1979 PDF downloadLoading ...