jimnoneill/paper-to-field-training huggingface dataset:
Finite-time parameter estimation in adaptive control

Field: Computer Science (Physical Sciences)

In the conventional adaptive control algorithms, the focus is on the tracking of a given reference trajectory and in most cases parameter estimation errors are not guaranteed to converge to zero due to lack of excitation. Parameter convergence is an important issue as it enhances the overall stability and robustness properties of the closed-loop adaptive systems. Moreover, there are control problems whereby the reference trajectory is not known a priori but depends on the unknown parameters of the system dynamics. For example, in adaptive extremum-seeking control problems, the desired target is the operating setpoint that optimizes an uncertain cost function.
P233 Is routine blood monitoring for suppressive herpes treatment necessary?: Abstract P233 Table 1

Field: Medicine (Health Sciences)

Background

There is no published evidence on the need for routine blood monitoring for people requiring daily oral acyclovir. Locally clinical practice differred between services. Dose reduction in moderate to severe renal impairment is recommended. Guidance for intravenous administration recommends measuring full blood count (FBC), renal (U&E) and liver function (LFTs) periodically.

Methods

In 2013 we reviewed clinical notes coded for herpes suppression to establish whether BASHH and local standards were met for management of herpes suppression and routine blood monitoring.

Results

41 cases were reviewed. 32 (73%) had baseline blood tests. Of these 6/32 (19%) had abnormal results: 2 raised LFTS, 2 low estimated Glomerular Filtration Rate (eGFR), 2 low neutrophils – all resolved on repeating except one with fluctuating neutropenia. 19/32 (47%) had bloods repeated at our service and additional 16% advised to attend GP. Only 1/19 (5%) had normal baseline bloods, low eGFR at one month, but normal at 2 months.

Discussion

19% of those tested had blood abnormalities at baseline, but only 3% had on-going abnormalities likely affected by acyclovir. We recommend checking U&E, LFT and FBC at baseline. If normal no further monitoring is needed. If mildy abnormal repeat but continue aciclovir. If significantly low eGFR, leucopenia or elevated LFTs either dose reduce or stop acyclovir and investigate.
Comparative Study of Widal Test and IgM ELISA in the Diagnosis of Typhoid Fever

Field: Medicine (Health Sciences)

BACKGROUNDTyphoid fever is an intense multi-system illness characterized by extended fever, and sustained bacteraemia.Typhoid fever is especially predominant in developing countries, where the standard of personal hygiene is poor with incidence of contaminated food, and water.It is endemic in India.Diagnosis of typhoid fever at an early stage is very critical.Salmonella Typhi isolation from bone marrow is the gold standard method for confirming a case of typhoid fever, but requires well trained personnel and equipment.Hence, there is a need for alternate methods of diagnosis.We wanted to compare the effectiveness and reliability of the Widal test and ELISA for the diagnosis of typhoid fever. METHODSA total of 57 blood samples was collected from patients from Kempe Gowda Institute of Medical Sciences, during period of August 2017 and September 2017.Samples were subjected to Widal and IgM ELISA.This is a prospective observational study. RESULTSOut of the 57 samples tested, 7 tested positive for Widal at a titre of 1:160 and above, and 7 tested positive for the IgM ELISA.50 were negative by both Widal and ELISA, 4 were positive by both Widal and ELISA, 3 were positive by Widal but negative by ELISA and 3 were negative by Widal but positive by ELISA.Additionally, 2 samples that were negative by Widal (Titre = 1 : 80) with advice to repeat the test after 1 week were positive by ELISA. CONCLUSIONSThere is a need for an alternative method for diagnosing Typhoid fever, Widal now being the standard test, is less reliable when compared to blood culture, which is practically not feasible in all areas.IgM ELISA can serve as a rapid test and can detect the illness in the first week of illness and results can be obtained within few hours.This gains importance in early diagnosis and hence better management of the disease.
Experimental Study of TNF-α in Reversal of Multidrug Resistance

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Objctive: To study the role and molecular mechanism of tumor necrosis facter alpha (TNFα) in reversal of mul-tidrug resistance ( MDR). Methods: Reverse rate of TNFα to MDR was analyzed by MTT assay, the effect of TNFα on MDR gene expression at mRNA by RT-PCR and at proteins by flow cytometry . Results: Reverse rates of TNFα to MDR inducing bymdrj, LRP, GSTP1 and TopoⅡα gene were 90.09% - 100% , by MRP was 0.00% -6.81%. TNFα weakened the mdr1、LRP and GSTp1 gene expression and enhanced the TopoⅡα gene expression, but had no obvious influence on MRP gene expression. Conclusion: TNFα was proved as a complex-reversal agent in vitro studies.
Novel transcriptional regulators of neuroblast self-renewal in Drosophila larval brains

Field: Neuroscience (Life Sciences)

Mechanisms of self-renewal in neural stem cells are conserved across organisms and are crucial in understanding cancer biology. Type II neural stem cells in Drosophila (neuroblasts) are akin to mammalian stem cells in many ways and are thus a popular model for studying these processes. In this report, we describe a genetic screen to isolate transcriptional regulators interacting with hyrax, a component of the PAF1C complex – a pleiotropic regulator which was recently discovered to influence neuroblast self-renewal. Our study identified 6 novel transcriptional regulators which may interact with hyrax. These results provide a starting point in studying neuroblast morphogenesis, allowing us to further construct the complexed network controlling stem cell self-renewal. As many of these mechanisms are highly conserved, Drosophila neuroblasts can serve as an instructive model for the self-renewal machinery in mammalian neural progenitors.
A New Huanglongbing Species, “ Candidatus Liberibacter psyllaurous,” Found To Infect Tomato and Potato, Is Vectored by the Psyllid Bactericera cockerelli (Sulc)

Field: Agricultural and Biological Sciences (Life Sciences)

ABSTRACT A new huanglongbing (HLB) “ Candidatus Liberibacter” species is genetically characterized, and the bacterium is designated “ Candidatus Liberibacter psyllaurous.” This bacterium infects the psyllid Bactericera cockerelli and its solanaceous host plants potato and tomato, potentially resulting in “psyllid yellowing.” Host plant-dependent HLB transmission and variation in psyllid infection frequencies are found.
Gate-Based Variational Quantum Algorithm for Truss Structure Size Optimization Problem

Field: Computer Science (Physical Sciences)

Quantum computing has become a pivotal innovation in computational science, offering novel avenues for tackling the increasingly complex and high-dimensional optimization challenges inherent in engineering design. This paradigm shift is particularly pertinent in the domain of structural optimization, where the intricate interplay of design variables and constraints necessitates advanced computational strategies. In this vein, the gate-based variational quantum algorithm utilizes quantum superposition and entanglement to improve search efficiency in large solution spaces. This paper delves into the gate-based variational quantum algorithm for the discrete variable truss structure size optimization problem. By reformulating this optimization challenge into a quadratic, unconstrained binary optimization framework, we bridge the gap between the discrete nature of engineering optimization tasks and the quantum computational paradigm. A detailed algorithm is outlined, encompassing the translation of the truss optimization problem into the quantum problem, the initialization and iterative evolution of a quantum circuit tailored to this problem, and the integration of classical optimization techniques for parameter tuning. The proposed approach demonstrates the feasibility and potential of quantum computing to transform engineering design and optimization, with numerical experiments validating the effectiveness of the method and paving the way for future explorations in quantum-assisted engineering optimizations.
A parallel compensated Horner scheme for SIMD architecture

Field: Computer Science (Physical Sciences)

A parallel algorithm for accurate polynomial evaluation is proposed for SIMD architectures. This is a parallelized version of the compensated Horner scheme using error-free transformations. The proposed parallel algorithm in this paper is fast and is designed to achieve a result as if computed in twice the working precision and then rounded to the working precision. Numerical results are presented showing the performance of this new parallel algorithm.
Decision letter for "The late consolidation of an aversive memory is promoted by VTA dopamine release in the dorsal hippocampus"

Field: Neuroscience (Life Sciences)

The hippocampus has been implicated in the processing and storage of aversive memories but the precise mechanisms by which these memories persist in time remain elusive. We have demonstrated that dopaminergic neurotransmission in the dorsal hippocampus regulates the long-term storage of both appetitive and aversive memories at a critical time point known as "late consolidation" (12 hr after the learning experience). This modulation appears to have opposite effects depending on the valence of the stimuli, with hippocampal dopamine release peaking immediately and 13-17 hr after a rewarding experience. Here, we determined the release pattern of hippocampal dopamine following an aversive experience, in order to better understand this opposite modulation process. We observed significant increases in dopamine levels at several times (6-8, 11-12, and 15 hr) after subjecting rats to a conditioned place aversion (CPA) task with the aversive agent lithium chloride (LiCl). Early pharmacological blockade of hippocampal DA receptors impaired CPA memory consolidation. In addition and consistent with previous findings showing that late post-training infusions of dopaminergic agents into the hippocampus modulate the long-term storage of aversive memories, we found that the photostimulation of dopaminergic VTA fibers in the dorsal hippocampus 11-12 hr after CPA training was enough to transform a short-lasting long-term memory into a long-lasting one. The fact that the persistence of an aversive memory can still be affected several hours after the learning experience opens new avenues to develop behavioral and pharmacological strategies for the treatment of a variety of mental disorders.
Evolutionary Ecology of Odonata: A Complex Life Cycle Perspective

Field: Agricultural and Biological Sciences (Life Sciences)

Most insects have a complex life cycle with ecologically different larval and adult stages. We present an ontogenetic perspective to analyze and summarize the complex life cycle of Odonata within an evolutionary ecology framework. Morphological, physiological, and behavioral pathways that generate carry-over effects across the aquatic egg and larval stages and the terrestrial adult stage are identified. We also highlight several mechanisms that can decouple life stages including compensatory mechanisms at the larval and adult stages, stressful and stochastic events during metamorphosis, and stressful environmental conditions at the adult stage that may overrule effects of environmental conditions in the preceding stage. We consider the implications of these findings for the evolution, selection, and fitness of odonates; underline the role of the identified numerical and carry-over effects in shaping population and metapopulation dynamics and the community structure across habitat boundaries; and discuss implications for applied conservation issues.
Border alert system and emergency contact for fisherman using GPS

Field: Engineering (Physical Sciences)

Augmenting strains over the ocean fringes brought on much devastation between two nations. Anglers from any nation are being snatched by the naval force for intersection the fringe which is accidental the majority of the circumstances. The viable generation of this framework manages following the area of the watercraft using GPS, it gives solid arranging route and timing facilities to overall clients on a consistent substructure in all climate, day and night on or proximate to earth and trigger an exhortation message, when the outskirt is drawn nearer or crossed. Withal, in additional organize, the GPS data is sent to costal sentinel and the celerity of the watercraft motor gets off by the control of fuel supply to motor. Subsequently sentinels in the shore can profit and give supplemental benefit to the anglers and profit them not to move past the outskirt
Educating in History: Thinking Historically through Historical Reenactment

Field: Arts and Humanities (Social Sciences)

This paper aimed to identify trends in the scientific literature that relate the link between two concepts: historical thinking and historical reenactment. The definition of both concepts and their commonalities were examined. Convinced that History instruction and Heritage education could improve new methods and techniques, and aware of the benefits of reenactments in active learning and participation in and outside the classroom, we came to the obvious conclusion that merging both aspects is a must and should be disseminated. We also analyzed the presence of second-order concepts in reenactment practices and how they are addressed by actors and spectators. Reenactments foster the acquisition of critical thinking by citizens through education; their quality, however, must be improved through research and didactics—didactics based on reenactment that help us value the past and the traces still present in local areas. Local and global identity and heritage, emotions, reproduction of objects, the use of sources, relevance, empathy, multiperspectives, causation, communication, the relationship between past and present, and the sustainable economy proposed by the 2030 Agenda, are all aspects that should take center stage in turning this phenomenon into a living and lasting history as an experience.
Mix-CPT: A Domain Adaptation Framework via Decoupling Knowledge Learning and Format Alignment

Field: Computer Science (Physical Sciences)

Adapting general large language models (LLMs) to specialized domains presents great challenges due to varied data distributions. This adaptation typically requires continual pre-training on massive domain-specific corpora to facilitate knowledge memorization, followed by training to apply this knowledge following human instructions and preferences. However, this method may result in inefficient knowledge memorization due to a lack of awareness of knowledge utilization and imposes substantial demands on LLMs to simultaneously learn knowledge utilization and format alignment with limited training samples. To facilitate the domain adaptation of LLM, we revise this process and propose a new domain adaptation framework including domain knowledge learning and general format alignment, called Mix-CPT. Specifically, we first conduct a knowledge mixture continual pre-training that concurrently focuses on knowledge memorization and utilization, allowing for mutual reinforcement. To avoid catastrophic forgetting during the continual pre-training process, we further incorporate a logit swap self-distillation constraint. Subsequently, leveraging the knowledge and capabilities acquired during continual pre-training, we efficiently perform instruction tuning and alignment with a few general training samples to achieve format alignment. Extensive experiments demonstrate that our proposed Mix-CPT framework can simultaneously improve the task-solving capabilities of LLMs on the target and general domains compared to the traditional adaptation methods.
A set of voltage-switched magnetic-core decoding matrices

Field: Engineering (Physical Sciences)

A class of decoders is described which translates an input of N bits to a unique output signal on one of 2N output line s. This operation is equivalent to that performed by diode decoding matrices except that the output may be a current pulse of several hundred ma (milliamperes) rather than a logical level. The logic on which these decoders are based is described and implementations of it which use only magnetic cores, wires, resistors, and standard semiconductor circuit elements are analyzed. These implementations require as few as N+1 cores, N+1 related drivers, and a single current source. Decoding is accomplished by current steering. Consideration is also given to the use of these matrices for error detection and correction in redundant codes.
~>PDF @*BOOK Data, Models, and Decisions: The Fundamentals of Management Science FOR ANY DEVICE

Field: Decision Sciences (Social Sciences)

Read Or Download Data, Models, and Decisions: The Fundamentals of Management Science Full Books By by {&quot;isAjaxInProgress_B001HD1YP4&quot;:&quot;0&quot;,&quot;isAjaxComplete_B001HD1YP4&quot;:&quot;0&quot;} Dimitris Bertsimas (Author) &acirc;&euro;&ordm; Visit Amazon&#39;s Dimitris Bertsimas Page Find all the books, read about the author, and more. See search results for this author Are you an author? Learn about Author Central Dimitris Bertsimas (Author), Robert Freund (Author)\n\n\nRead Online =&gt; Read Data, Models, and Decisions: The Fundamentals of Management Science\n\n\nDownload Book =&gt;&nbsp;Download Data, Models, and Decisions: The Fundamentals of Management Science\n\n\nData, Models, and Decisions: The Fundamentals of Management Science pdf download\nData, Models, and Decisions: The Fundamentals of Management Science read online\nData, Models, and Decisions: The Fundamentals of Management Science epub\nData, Models, and Decisions: The Fundamentals of Management Science vk\nData, Models, and Decisions: The Fundamentals of Management Science pdf\nData, Models, and Decisions: The Fundamentals of Management Science amazon\nData, Models, and Decisions: The Fundamentals of Management Science free download pdf\nData, Models, and Decisions: The Fundamentals of Management Science pdf free\nData, Models, and Decisions: The Fundamentals of Management Science pdf\nData, Models, and Decisions: The Fundamentals of Management Science epub download\nData, Models, and Decisions: The Fundamentals of Management Science online\nData, Models, and Decisions: The Fundamentals of Management Science epub download\nData, Models, and Decisions: The Fundamentals of Management Science epub vk\nData, Models, and Decisions: The Fundamentals of Management Science mobi\n\n\n\n#downloadbook #book #readonline #readbookonline #ebookcollection #ebookdownload #pdf #ebook #epub #kindle
Regulation of γδ T cell effector fate specification by ribosomal protein paralogs (HEM3P.285)

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract γδ T cells are key mediators of inflammation that play a crucial role in preserving epithelial barriers and eradicating cutaneous tumors. The molecular mechanisms that control γδ T cell development and function, however, remain poorly understood. We have previously reported that the ribosomal protein paralogs Rpl22 and Rpl22l1 have antagonistic roles during hematopoietic stem cell emergence. Consequently, we sought to determine if Rpl22 and Rpl22l1 might play roles in more differentiated hematopoietic lineages. We have now demonstrated that γδ T cell development is not arrested in the absence of Rpl22 or Rpl22l1, suggesting these proteins are dispensable γδ T cell development; however, Rpl22 and Rpl22l1 do appear to regulate the specification of γδ effector fate during development in the thymus and have opposing roles in this process. Specifically, Rpl22-deficiency enhances the generation of IL-17-producing γδ T cells. In contrast, Rpl22l1-deficiency leads to an expansion of IFN-γ-producing γδ T cells and, in particular, the Vγ1.1+ innate-like γδ T cell subset. Rpl22 and Rpl22l1 are RNA-binding proteins that exert their control over developmental processes extraribosomally (i.e., away from the ribosome) by binding and regulating the expression of cellular RNA targets. Our efforts to identify the key cellular RNAs through which Rpl22 and Rpl22l1 influence γδ T cell effector fate will be presented.
Peningkatan hasil belajar PKn siswa materi sumpah pemuda dalam bingkai bhineka tunggal ika melalui aplikasi google classroom pada kelas VIII SMP

Field: Social Sciences (Social Sciences)

<div>The purpose of this classroom action research is to determine the extent to which the Google Classroom application is able to improve the learning outcomes of Class VIII b students in Citizenship Education (PKn) Subjects on Youth Pledge Material in the frame of diversity of unity at SMP Negeri 34 Semarang in the even semester of the school year. 2020/202. This research was conducted in 2 cycles. The subjects of this study were class VIII B in the second semester at SMP Negeri 34 Semarang in the 2020/2021 school year with a total of 31 students. The data analysis technique used was qualitative descriptive analysis and continued reflection. The results showed that: Based on the discussion and research results, it can be concluded that the application of the google classroom application in online learning cycle II has shown maximum results. The learning outcomes obtained were better than during the implementation of PKn learning activities in cycle I. Problem discovery in action, namely problems from teachers and students, can be anticipated. There are problems that arise from students whose participation is low, because they are constrained by the internet network. The results obtained by all students showed that the final ability was better than the initial ability before the action by showing the results of observations on the activeness of students in participating in learning activities through the google classroom application. From the results of the implementation of learning improvement and reflection in cycle II, it can be concluded that the implementation of learning actions through google classroom to improve student learning outcomes in participating in PKN learning activities can be ended in cycle II with satisfactory results with students experiencing completeness as a whole.</div>
Preparation of highly active enterogastrone

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

By using a 10% pure preparation of cholecystokinin–pancreozymin (CCK–PZ) a fraction was obtained which was inhibitory for H + secretion, pepsin secretion, and motor activity in antral and fundic pouches. This material possessed no significant CCK–PZ activity or secretin-like activity.
A 3D Adult Zebrafish Brain Atlas (AZBA) for the Digital Age

Field: Neuroscience (Life Sciences)

Zebrafish have made significant contributions to our understanding of the vertebrate brain and the neural basis of behavior, earning a place as one of the most widely used model organisms in neuroscience. Their appeal arises from the marriage of low cost, early life transparency, and ease of genetic manipulation with a behavioral repertoire that becomes more sophisticated as animals transition from larvae to adults. To further enhance the use of adult zebrafish, we created the first fully segmented three-dimensional digital adult zebrafish brain atlas (AZBA). AZBA was built by combining tissue clearing, light-sheet fluorescence microscopy, and three-dimensional image registration of nuclear and antibody stains. These images were used to guide segmentation of the atlas into over 200 neuroanatomical regions comprising the entirety of the adult zebrafish brain. As an open source, online (azba.wayne.edu), updatable digital resource, AZBA will significantly enhance the use of adult zebrafish in furthering our understanding of vertebrate brain function in both health and disease.