jimnoneill/paper-to-field-training huggingface dataset:
Regulation of macrophage phagocytosis of apoptotic neutrophils by adhesion to fibronectin.

Field: Immunology and Microbiology (Life Sciences)

Abstract The potential for leukocyte-mediated host tissue damage during resolution of inflammatory responses is influenced by the rate at which extravasated apoptotic leukocytes are cleared from inflammatory sites. Regulation of macrophage capacity for clearance of apoptotic granulocytes is likely to be an important factor determining whether inflammation ultimately resolves or progresses to a chronic state. In this study we have investigated the molecular basis for rapid augmentation of macrophage phagocytosis of apoptotic neutrophils, which was observed following macrophage adhesion to fibronectin. We used a combination of monoclonal antibodies, blocking peptides, and recombinant fibronectin fragments to investigate the role of β1 integrins in mediating the fibronectin effects. Blockade of α5β1 or α4β1 alone did not attenuate fibronectin-augmentation of phagocytosis. In addition, adhesion of macrophages to recombinant fibronectins lacking α4β1 recognition motifs failed to promote phagocytosis of apoptotic neutrophils. Our results would be consistent with a model in which multiple fibronectin receptors, including β1 integrins, act cooperatively to augment macrophage phagocytic responses. Together, these data suggest that the extracellular matrix environment of macrophages may provide regulatory signals that act indirectly to rapidly alter the potential for removal of apoptotic cells and influence the process of resolution of inflammation. J. Leukoc. Biol. 64: 600–607; 1998.
Gypenosides Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis by Inhibiting the Differentiation of Hepatic Progenitor Cells into Myofibroblasts

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Gypenosides (GPs), the predominant components of Gynostemma pentaphyllum, exert antifibrotic effects; however, the mechanisms underlying their ability to ameliorate liver fibrosis are unclear. Liver fibrosis was induced in C57BL/6 mice via subcutaneous injection of 10% carbon tetrachloride (CCl[Formula: see text] three times a week for two weeks. Then, CCl 4 was administered in conjunction with intragastric GPs for another three weeks. For in vitro analyses, WB-F344, hepatatic progenitor cells (HPCs) were treated with transforming growth factor beta 1 (TGF-[Formula: see text]1) with or without GPs for 48[Formula: see text]h. The results showed that alanine aminotransferase (ALT) and aspartate transaminase (AST) activity, deposition of collagen, hydroxyproline content, and expression of alpha-smooth muscle actin ([Formula: see text]-SMA) and collagen type I (Col I) were significantly decreased after treatment with GPs ([Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text]). In the 5M CCl 4 group, the expression of HPC markers, Sox9 and cytokeratin 19 (CK19), was significantly increased compared with the normal or GPs-treated group ([Formula: see text], [Formula: see text]). Immunostaining showed that the number of Sox9 and [Formula: see text]-SMA double-positive cells was higher in the 5M CCl 4 group than in the normal group, but the addition of GPs caused this cell number to decrease. In WB-F344 cells, the expression of [Formula: see text]-SMA and Col I was significantly increased after treatment with TGF-[Formula: see text], whereas in the GPs treatment group, expression was markedly decreased ([Formula: see text]). The levels of TGF-[Formula: see text] and TGF-[Formula: see text]R1 were markedly reduced after GPs treatment both in vivo and in vitro. In conclusion, GPs ameliorated CCl 4 -induced liver fibrosis via the inhibition of TGF-[Formula: see text] signaling, consequently inhibiting the differentiation of HPCs into myofibroblasts.
Effects of highway construction on soil quality in the Longitudinal Range-Gorge Region in Yunnan Province

Field: Environmental Science (Physical Sciences)

在在西南的中国的纵的范围峡区域包围生态系统之上的高速公路建设的影响基于地调查和试验性的分析被检测。我们在达利上进行了研究(从达利城市到丽江城市)省的道路， Dabao (从达利城市到 Baoshan 城市)高速公路和 Baolong (从 Baoshan 城市到 Longling 县)在纵的范围峡区域的高速公路用包围土壤质量的 space-for-time 替换，和预言的补习的方法玷污质量在包围上检测高速公路建设的效果。结果显示出那：(1 ) 自然、栽培的土壤质量上的高速公路建设的效果是重要的，并且效果比在使用的高速公路的时期在高速公路建设的时期是更重要的。(2 ) 高速公路建设的效果是更明显的在上比 upslope，和效果范围下坡是 200 m 在上下坡，当时 upslope 上的 150 m。(3 ) 土壤补习主要与高速公路建设，高速公路服务时间，植被恢复，土壤有机物和土壤的效果程度有关全部的氮，在哪个之中，高速公路建设是最重要的因素。(4 ) 当植被范围能被恢复到 30% 原来的状况时，土壤质量罐头在 10 年以后被补救到 44% 原来的状况，一旦它被破坏，显示土壤富饶补习是相当困难的。
Identification of a small peptide targeting the Raf/ Galectin interface to disrupt stabilised Ras signalling nanocluster

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The three genes, HRAS, NRAS and KRAS, are mutated in 19 % of cancers and in several developmental diseases called RASopathies. Despite the recently approved K-RAS-G12C inhibitor Sotorasib there are only very few treatment options for other RAS proteins. Active RAS is organized in di/oligomers at the plasma membrane in proteo-lipid complexes called nanoclusters. Nanoclustering of H-RAS can be increased by the nanocluster scaffold galectin-1 (Gal-1), which augments MAPK-output. We have shown previously that Gal-1 interacts with the RAS-binding domain (RBD) of the effector Raf. We proposed a model, wherein Gal-1 dimers stabilize dimers of Raf when in complex with active H-RAS, thus stabilizing the active RAS nanocluster. Therefore, interference with the Gal-1/ Raf-RBD interaction represents a novel opportunity to normalize Gal-1 augmented RAS/MAPK signaling. We have identified the L5UR peptide, which competes with the binding of the C-Raf-RBD to Gal-1 in BRET assays and blocks Gal-1 increased H-RAS nanoclustering. Further characterization of L5UR suggests that it can serve as a new starting point for generating chemical-biological tools, such as competing peptidomimetics or degraders that would disrupt RAS nanoclustering and signaling.
The physiological basis for fetal assessment.

Field: Medicine (Health Sciences)

Remarkable progress has been made during the last 15 years in understanding mechanisms that occur in the fetus as a response to hypoxia. Human experiments have defined the normal patterns and responses of the fetus to changes in the maternal environment. Considerable data exist regarding patterns of fetal breathing and body movements and of the FHR during midpregnancy in humans. Unfortunately, very little data exist from animal experiments during midpregnancy to confirm the usefulness of indices of fetal activity and blood flow during this important time in gestation. At the present time, it is sensible to conclude that a scientific basis exists for the application of fetal testing methods such as the biophysical profile, NST, and arterial wave-form velocities during the last 10 weeks of human pregnancy. However, it is important to recognize that the scientific basis for the use of such tests does not exist from animal experiments during the important period of 0.5 to 0.75 of gestation. As a result, clinicians need to be cautious regarding the interpretation of measurements made between 20 and 30 weeks' gestation. At present, fetal tests are based on observation of normal fetal behavior. The methods are time-consuming, labor-intensive, and subject to error because of the periodicities in fetal activity. The purpose of this symposium is to consider whether measurement of fetal responses to sound and vibration might be a more effective method of assessing fetal health. It is to be hoped that such new methods will be vigorously investigated before introduction into clinical practice.
Mating Strategies of Philanthine Digger Wasps

Field: Agricultural and Biological Sciences (Life Sciences)

This research is part of continuing study of the ethology of digger wasps of the subfamily Philanthinae (Hymenoptera, Sphecidae). At the present time major effort is being directed toward study of mating strategies in the genus Philanthus. There are five species of this genus in Jackson Hole (Evans, 1970). Two of these are more common elsewhere and are being studied elsewhere. Preliminary studies on the remaining three in 1977 revealed striking differences between the three and in one case a mating system unique among digger wasps (Evans & O'Neill, 1978). During late June and the first half of July, 1978, we made an effort to further confirm this unique system in P. zebratus and to obtain further data on P. pulcher, a very common early summer species in Jackson Hole. These efforts were successful, but P. pulcher also proved unique in some respects and we hope to continue studies of this species in the future. Other species of Philanthus are being studied elsewhere by our group, and we hope to include all of these comparative data in a behavioral monograph on the Philanthinae.
Three-dimensional reconstructionof the congenital cleft of the ear lobule with lipo-dermal flap.

Field: Medicine (Health Sciences)

Objectives-Because of the variable amount of deficit of tissue in cleft ear lobule, Reconstruction of Congenital clefts of ear lobule is challenging so treatment of congenital clefts of ear lobule needs customization to deal with the deficient volume of tissue in three dimensions (thickness, length, and width). In this series, we describe the three-dimensional reconstruction of the congenital cleft of the ear lobule with lipo-dermal flap and the evaluation of clinical outcomes in terms of the aesthetic expectation of the patient. Materials and methods- Patients of all age groups and gender who presented with fresh congenital cleft of ear lobule underwent Three-dimensional reconstruction with lipo-dermal flap from 2017 to 2022 were included. We used customized repair for deficient tissue of the congenital cleft of the lobule by de-epithelizing skin of all cleft surfaces and raising lipo-dermal flap. Results- Out of (06) cases, one case was male and 5 cases were females, with an average age group of 20.16 years. 33.33% of the congenital cleft of lobule was presented with three lobes and 66.6% of cases presented with two lobes. The aesthetical appearance was assessed as per criteria and was found good in 83.3% and very good in 16.6% of cases. Conclusions- Three- dimensional reconstruction of the congenital cleft of the ear lobule with lipo-dermal flap is a simple and effective technique to correct lobule deformities in proportion to the extent of the cleft and yields an aesthetically good pleasing ear lobule which matches with opposite side ear without complications.
Spatial Distribution of Phase Singularities in Ventricular Fibrillation

Field: Medicine (Health Sciences)

Background— Multiple excitation wavelets are present during ventricular fibrillation (VF). The underlying wavelet organization of VF is unclear. Phase singularities (PSs)—locations of ambiguous activation state—underlie reentry and wavelet splitting and represent the sources of VF. Understanding the mechanisms of PS formation might be important in the development of effective therapies for sudden death. Methods and Results— We performed voltage, phase, and PS mapping in fibrillating ventricles, applying an automated PS detection algorithm to optically recorded fibrillation signals. PS clustering was noted along epicardial vessels, ridges of endocardial trabeculae, and papillary muscle insertions. Microscopically, these locations correlated with areas of apposition of fibers with different angulations and intramural vessels. A total of 83.2% of PSs were formed at and meandered about these anatomic structures, which acted as stabilizers: PSs colocalizing at anatomic substrates had longer life spans than nonanatomic PS (82.46±60.8 versus 40.5±31.9 ms, P <0.01). The RV endocardium had a higher PS incidence than the epicardium (42.3±9.2 versus 23.5±11.6 PS/s, P <0.01). Autocorrelation showed that irregular behavior was spatially restricted to anatomic heterogeneities compared with other areas, which had nearly periodic behaviors. Simple spatial PS distributions underlay complex and variable activation patterns attributable to variable PS behaviors, life spans, and inter-PS interactions. Conclusions— PSs occur in a nonrandom spatial distribution and colocalize with normal anatomic heterogeneities. Varying PS behaviors and life spans but stable PS spatial distributions cause ever-changing activation patterns that characterize VF.
Regeneration of beta cells in islets of Langerhans of pancreas of alloxan diabetic rats by acetone extract of Momordica charantia (Linn.) (bitter gourd) fruits.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Acetone extract of whole fruit powder of M. charantia (bitter gourd) in doses 25, 50 and 75 mg/100 g body weight lowered the blood glucose from 13.30 to 50% after 8 to 30 days treatment in alloxan diabetic albino rats, confirming antihyperglycemic effect of this plant in diabetic animals and humans. Histological observations with acetone extract showed different phases of recovery of beta cells of the islets of Langerhans of pancreas, which in the untreated diabetic rats were less in number and showed varied degree of atrophy. The most important finding of the present study was observation of the presence of small scattered islets among the acinar tissue in some experimental animals, which may reflect neoformation of islets from pre-existing islet cells. The liver of alloxan diabetic rats showed hydropic degeneration, fatty change and necrosis at some places but liver of extract treated animals was normal. Glycogen localization in liver of diabetic rats was faint but after 30 days treatment with different doses of extract, normal to heavy glycogen localization was observed.
Analisis Aktivitas Investasi dan Pendanaan pada Perusahaan yang Terdaftar di BEI (Pada PT. Hero Supermarket Tbk Tahun 2020-2022)

Field: Business, Management and Accounting (Social Sciences)

Investing activity is the acquisition and disposal of long-term assets and other investments that are not included in cash equivalents. 4. Financing activities are activities that result in changes in the amount and composition of Bank capital and loans. This study aims to present: (1) analysis of investment activities in PT. HERO SUPERMARKET TBK, (2) analysis of funding activities at PT. Hero Supermarket Tbk. The design of this research is quantitative research and data research. The data studied are the national financial reports from the Indonesian stock exchange PT. Hero Supermarket Tbk, the results of the study show that (1) investment activity at PT. Hero Supermarket Tbk, showing good performance so that investment continues to increase every year, (2) financing activities run smoothly and stably despite being disrupted by the Covid-19 outbreak in Indonesia.
Issue Publication Information

Field: Materials Science (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleIssue Publication InformationCite this: ACS Appl. Mater. Interfaces 2022, 14, 8, XXX-XXXPublication Date (Web):March 2, 2022Publication History Published online2 March 2022Published inissue 2 March 2022https://doi.org/10.1021/amv014i008_1560034Copyright © 2022 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views20Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (143 KB) Get e-Alerts Get e-Alerts
Penerapan Distinction Principle Dalam Perundang-Undangan di Indonesia

Field: Social Sciences (Social Sciences)

The ratification of the 1949 Geneva Convention implies that Indonesia must obey and implement international humanitarian law, specifically the distinction principles. One of the distinction principle relates to the separation of civilian objects and military objects, where attacks are only passed on to military objects. civilian objects and military objects in Indonesia are practically not separated and close together. This has the potential to become a threat if it does not follow the rules in international humanitarian law. The purpose of this study is to find out the importance of applying the distinction principle regarding civil objects and military objects in legislation in Indonesia. This writing uses a normative legal research method, the approach is carried out through a legislative approach and a conceptual approach. The results of the study indicate that the separation of civilian and military objects is a preventive effort in protecting civilians and civilian objects in the event of war or armed conflict. Although it has been a party to the 1949 Geneva convention, the application of the principle of differentiation has not yet been fully implemented by Indonesia, there are no specific regulations regarding the separation of civilian and military objects in its national legislation. Ratifikasi Konvensi Jenewa 1949 berimplikasi adanya kewajiban Indonesia untuk mematuhi dan melaksanakan hukum humaniter internasional, khsusnya prinsip pembedaan. Salah satu prinsip pembedaan terkait pemisahan objek sipil dan objek militer, di mana ketika berperang serangan-serangan hanya dibenarkan ke objek-objek militer saja. Objek sipil dan objek militer di Indonesia secara praktik tidak dipisahkan atau berdekatan. Ini berpotensi menjadi ancaman khususnya bagi keselamatan penduduk sipil apabila tidak mengikuti aturan di dalam hukum humaniter internasional. Tujuan penelitian ini adalah untuk mengetahui pentingnya penerapan distinction principle terkait objek sipil dan objek militer dalam perundang-undangan di Indonesia. Penulisan ini menggunakan metode penelitian hukum normatif, dengan melakukan pendekatan melalui perundang-undangan dan pendekatan konseptual. Hasil penelitian menunjukkan bahwa Pemisahan objek sipil dan militer merupakan upaya preventif dalam melindungi penduduk sipil dan objek-objek sipil jika terjadi perang atau konflik bersenjata. Meskipun telah menjadi pihak dalam konvensi jenewa 1949, penerapan prinsip pembedaan belum sepenuhnya dilaksanakan oleh Indonesia, belum ada peraturan khusus terkait pemisahan objek sipil dan militer dalam legislasi nasionalnya.
The Development of Spanish Airpower Doctrine (1910-1936)

Field: Social Sciences (Social Sciences)

Abstract : The development of Spanish airpower doctrine has not been specifically addressed in previous works or papers. The objective of this paper is to provide the reader with a comprehensive analysis of such a process in order to understand what were the reasons that delayed the independence of the Spanish Air Force for so long. In describing this process, this paper focus on ideas, experiences, and organizational regulations that marked the development of Spanish airpower since its birth (1910) to 1936, just before the Spanish Civil War took place.
Life histories and descriptions of adults and immature stages of two cryptic species, aciurina ferruginea (Doane) and A. michaeli, new species (Diptera: Tephritidae), on Chrysothamnus viscidiflorus (Hooker) Nuttall in southern California

Field: Agricultural and Biological Sciences (Life Sciences)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Proposal of Transformer Using Magnetic Shielding With Bulk High&lt;tex&gt;$T_rm c$&lt;/tex&gt;Superconductors

Field: Physics and Astronomy (Physical Sciences)

As for a general transformer using a ferromagnetic core, the magnetic flux may leak by using the high frequency and the overload. When the magnetic flux leaks from the core, the secondary voltage and its power transfer efficiency decrease. Bulk high T/sub c/ superconductors (HTS's) with the high critical current density have the strong magnetic shielding characteristic at the static magnetic field and the AC magnetic field. Thus, we examined to surround a magnetic circuit of a transformer with bulk HTS's. From this research, when the magnetic circuit of the transformer was surrounded with plural HTS's, it was confirmed that the secondary voltage and the power transfer efficiency of the transformer increased especially in the high frequency range.
Atrial Septal Defect: Step-by-Step Catheter Closure

Field: Medicine (Health Sciences)

Transcatheter device closure of ASD has come a long way since the first experimental closure in dogs by Kings and Mills in 1972.However, unlike earlier devices, the current generation is easier to deploy and retrieve.The secret to a successful procedure includes meticulous planning and execution.It involves comprehensive evaluation from the point of appropriate case selection, detailed pre-and intra-procedural imaging, knowledge of various techniques of device deployment, and anticipating complications and ways to deal with them.In this paper, we describe the step-bystep procedure for transcatheter closure of an atrial septal defect using the Amplatzer Septal Occluder.
AmpC Enzyme,ESBLs Production and Antibiotic Resistance in Gram-negative Bacilli Isolated in Intensive Care Unit

Field: Medicine (Health Sciences)

OBJECTIVE To investigate the production of AmpC enzyme and ESBLs in Gram-negative bacilli and their drug-resistance to provide basis for reasonable use of antibiotics in clinical practice.METHODS All bacteria were identified by VITEK-32 system and disk test.RESULTS The main five strains of all 184 Gram-negative bacilli were Pseudomonas aeruginosa(24.4%),Acinetobacter baumannii(19.3%),Enterobacter cloacae(14.8%),Escherichia coli(10.2%) and Klebsiella pneumoniae(9.7%).The AmpC enzyme-producing rate was 53.8% and 14.7% in E.cloacae and A.baumannii the ESBLs-producing rate was 35.3%(12/34) and 15.4%(4/26) in A.baumannii and E.cloacae.P.aeruginosa was sensitive to imipenem and the drug-resistance rate of K.pneumoniae was 0%.CONCLUSIONS ESBLs and AmpC enzymes are important mechanisms of the drug-resistance of Gram-negative bacilli.