jimnoneill/paper-to-field-training huggingface dataset:
Exploring Dinesavalyadi Taila: A Comprehensive Pharmaceutical and Analytical Study in the World of Ayurvedic Medicine

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background: Wound healing poses a prevalent challenge in daily medical practice, despite the advancements in allopathic medicine. Managing chronic wounds remains a significant hurdle for clinicians. Notably, Acharya Sushrut recognized the importance of wound management and detailed 60 treatment modalities (shashthi upakramas), many of which incorporate the use of oil. Various research studies have explored the added benefits of topical oil application for wound healing. Aims: This study aims to prepare and analyze Dinesavalyadi Taila, a formulation mentioned in Sahasrayogam for wound healing, specifically Dhusta vrana. The analysis employs instrumental phytochemical marking tools like HPTLC and evaluates its antibacterial properties. Settings and Design: The study is conducted in a laboratory setting, with a design focused on the preparation and analytical examination of Dinesavalyadi Taila. Methods and Material : Dinesavalyadi Taila is prepared as per Sahasrayogam and subjected to analytical scrutiny. Instrumental phytochemical marking tools, including HPTLC, are utilized in the study. Results: The study's results provide insights into the formulation's composition and its potential for wound healing. The antibacterial effects are also assessed, shedding light on its therapeutic properties. Conclusions: Dinesavalyadi Taila, as described in Sahasrayogam, exhibits promise as a therapeutic agent for wound healing. The analytical examination, along with antibacterial studies, contributes valuable information regarding its potential clinical applications.
1H NMR profiling in colorectal cancer

Field: Medicine (Health Sciences)

Colorectal cancer remains a major cause of death and illness in Western society. Although advances have been made in its management over the past 2 decades, many challenges with appropriate treatment targeting, diagnosis and management remain. Addressing these challenges through the approach of ‘personalised healthcare’ is of increasing interest to researchers. This has been facilitated by recent advances in metabonomic techniques. This approach involves the investigation of metabolic consequences of disease downstream of the disease process, including the complex interaction between host and environment. Using 1H NMR spectroscopy, colorectal cancer tissue was analysed on patients operated on between 2007 and 2009. The first study in this thesis identifies the metabolic phenotype associated with the disease, and attempts to relate this to what is known about colorectal and other cancer metabolism. The second study utilises multivariate regression analysis to develop discriminatory models and panels of metabolites to differentiate between cancer stages and other clinical and pathological features of the tissue. In the third study, this approach was applied to an in-vitro cell model of 5-FU chemotherapy resistance to determine the metabolic pathways associated with this resistance. A distinct metabolic profile discriminating normal from cancerous tissue was identified. No such profile was able to discriminate tissue on the basis of cancer stage. Discreet metabolic changes were associated with 5-FU chemoresistance but were too few to make assumptions about mechanism. Colorectal cancer joins other solid tumours in expressing a distinct metabolic phenotype and metabonomic techniques provide insight into the mechanisms underlying the disease.
New methods in peptide synthesis, based on supernucleophiles

Field: Chemistry (Physical Sciences)

The fragmentation of S-halogenated alkyl groups and 5-halogenated butenyl groups from the N-and C-termini of a-amino acids and peptide derivatives by the supernucleophilic Coi-phthalocyanine anion as well as related reactions are presented as the basis of some new protecting group techniques and synthetic methods for peptides.
Ser betaceño en la CDMX: adaptación, permanencia y resistencia comunal

Field: Social Sciences (Social Sciences)

The objectives of this paper are to describe with two examples the recreation of communality in an urban context. And, to explain how the Betaceña community has recreated its culture through the communal practice (with the party). On the other hand, it is intended to account for how through these practices the members of this community have adapted to a new space, and have resisted the complexities that migration implies. Therefore, the recreated communality is considered as a form of Zapotec resistance in urban contexts. This analysis is of utmost importance, because it will contribute to blur the conceptions that are held about communality. In addition to visualizing other forms of Zapotec resistance. In order to obtain the results, this work used an ethnographic methodology. It mainly relied on participant observation and the elaboration of field diaries. Thus, the description and analysis of the empirical data resulted in the possibility of a decontextualized communality or a communality recreated through the party. Becoming the way in which the Betaceños adapt, remain and resist culturally in an urban context.
IDENTIFICATION OF CICHORIUM INTYBUS L. AND THEIR PHENETIC RELATIONSHIP REVEALED BY RAPDS

Field: Agricultural and Biological Sciences (Life Sciences)

Hydroponic forcing is commonly used to produce F1 hybrids of chicory (Cichorium intybus L. var. foliosum Hegi). A reliable method for cultivar identification in chicory is necessary at the seed and root level (protection of the chicory grower) as well as on the head tissue (protection for consumer and export). Cultivars cannot be distinguished from each other using morphological characteristics. Genetic polymorphism, generated by the use of RAPD markers, was tested in its efficiency for cultivar identification. RAPD analysis was performed on 24 commercial F1 hybrids used in hydroponic forcing (Cichorium intybus L. var. foliosum Hegi), 10 chicory cultivars for traditional forcing in soil, 2 red chicory cultivars (Cichorium intybus L. var. endivia), 4 industrial chicory cultivars used for inulin production (Cichorium intybus L. var. sativum) and 7 green-hearted chicory cultivars (Cichorium intybus L. var. foliosum). Based on 23 primers, it is now possible to separate the different chicory varieties and cultivars. Although a high similarity between chicory cultivars and varieties does exist, clear grouping of the different Cichorium intybus L. varieties was observed. It was concluded that RAPD is a valuable technique for cultivar identification in chicory especially for positive identification.
Scoping the Eco-sensitive Mythology in the Works of Amruta Patil and Appupen

Field: Arts and Humanities (Social Sciences)

Purpose of the study: The study aims to delve into the potential of the graphic novel in the Indian context, for which I have used the works of Amruta Patil and Appupen. The paper investigates the concerns of environment, mythology, and feminine experience and its presentation on a graphic-literary landscape. Methodology: The methodology used in the paper is that of direct observation. The researcher has used the contributions of Pramod K. Nayar and Emma Varughese further to push the boundaries of the graphic novel in India. Main Findings: The paper’s main findings have been to bring to light the complex mesh of interdisciplinary strategies required to scope the medium of the graphic novel. The paper narrows down on the success of the graphic novel as a medium to address the issues of the environment in a much more nuanced manner. Applications of the study: This research can be used to widen the scope of Literary Eco-criticism. It includes the medium of the graphic novel and seeks to examine its operative strategies when raising attention to the issues that pertain to the environment. Novelty/Originality of the study: The terrain of the Indian Graphic Novel is still new and developing. While some studies have been done in this medium around the themes of the concerns of the cosmopolitan Indian, little has been done to look into the mythological roots and environmental concerns that this genre also illuminates. This essay is a significant step in that direction.
List of sites in which fish were sampled during the Joint Danube Survey 4.

Field: Agricultural and Biological Sciences (Life Sciences)

List of sites in which fish were sampled during the Joint Danube Survey 4. Sites are listed from upstream (JDS01) to downstream (JDS50), with site IDs and WGS84 X and Y geographic coordinates for each location. The country (or countries) in which each site is located is shown next to the site name. Abbreviations: DE - Germany, AT - Austria, SK - Slovakia, HU - Hungary, SI - Slovenia, HR - Croatia, RO - Romania, BA - Bosnia and Herzegovina, RS - Serbia, ME - Montenegro, UA - Ukraine, MD - Moldova, BG - Bulgaria.
The Use of Insecticide-Treated Curtains for Control ofAedes aegyptiand Dengue Virus Transmission in “Fraccionamiento” Style Houses in México

Field: Medicine (Health Sciences)

Dengue, chikungunya, yellow fever, and Zika viruses transmitted by Aedes aegypti mosquitoes are major public health threats in the tropical and subtropical world. In México, construction of large tracts of “fraccionamientos” high density housing to accommodate population growth and urbanization has provided fertile ground for Ae. aegypti -transmitted viruses. We investigated the utility of pyrethroid-treated window curtains to reduce both the abundance of Ae. aegypti and to prevent dengue virus (DENV) transmission in fraccionamiento housing. Windows and doors of fraccionamiento homes in urban/suburban areas, where Ae. aegypti pyrethroid resistance associated with the Ile1016 knock down resistance (kdr) mutation in the voltage gated sodium channel gene was high, and in rural areas, where kdr resistance was low, were fitted with either insecticide-treated curtains (ITCs) or non-treated curtains (NTCs). The homes were monitored for mosquito abundance and DENV infection. ITCs reduced the indoor abundance of Ae. aegypti and the number of DENV-infected mosquitoes in homes in rural but not in urban/suburban study sites . The presence of non-treated screens also was associated with reduced numbers of mosquitoes in homes. “Super-infested” homes, yielding more than 50 mosquitoes, including DENV-infected mosquitoes, provide a significant public health risk to occupants, visitors, and people in neighboring homes.
Introduction

Field: Arts and Humanities (Social Sciences)

Extract The Yugoslav diplomat and author Ivo Andrić captured a regrettable phenomenon of human nature in his compelling description of atrocities against Serbs at the start of World War I: ‘That wild beast, which lives in man and does not dare to show itself until the barriers of law and custom have been removed, was now set free.’1 Narratives of the wild beast abound: Turkish massacres of Armenians during World War I, the Holocaust during World War II, and more recent tragedies in Andrić's homeland, where more than 7,500 men and boys were massacred at Srebrenica.2 Ten times that number died scarcely two years earlier in Rwanda.3 A decade into the new millennium, massacres and other violence against tribal peoples in Darfur continue to draw worldwide attention and condemnation.4 A common term ascribed to such atrocities is ‘genocide.’ Beginning with the Holocaust, the international community5 started...
“Choirochorographia, sive hoglandiæ descriptio”

Field: Arts and Humanities (Social Sciences)

“Choirochorographia, sive hoglandiæ descriptio” Get access R. H. S. R. H. S. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s5-X, Issue 259, 14 December 1878, Page 477, https://doi.org/10.1093/nq/s5-X.259.477b Published: 14 December 1878
Radioactive heat production characterization of Ar-Rassafeh Badyieh area (area-2), Syria by using aerial gamma ray spectrometric and fractal modeling techniques

Field: Earth and Planetary Sciences (Physical Sciences)

Aerial gamma-ray spectrometric technique is used herein to evaluate the radioactive heat production (HP) of Ar-Rassafeh Badyieh Area (Area-2), Syria. The nine already established lithological scored units of Area-2 have been separately characterized for the heat production HP parameter. The Concentration-number (C-N) model and the log-log plots associated with fractal technique are proposed and applied as a new approach to map the measured equivalent uranium (eU), the equivalent thorium (eTh), and potassium (K%) and the computed heat production (HP) of Area-2. The HP of Area-2 varies between a minimum of 0.06 and a maximum of 4.28 ?w/m3 with an average of 0.548 ?w/m3 and a standard deviation of 0.27?w/m3. The highest observed HP values are related to the phosphatic environments represented by two lithological scored units A and B.
The Logarithmic Picard group and its Tropicalization

Field: Mathematics (Physical Sciences)

We construct the logarithmic and tropical Picard groups of a family of logarithmic curves and realize the latter as the quotient of the former by the algebraic Jacobian. We show that the logarithmic Jacobian is a proper family of logarithmic abelian varieties over the moduli space of Deligne-Mumford stable curves, but does not possess an underlying algebraic stack. However, the logarithmic Picard group does have logarithmic modifications that are representable by logarithmic schemes, all of which are obtained by pullback from subdivisions of the tropical Picard group.
The Validity And Reliability of The Turkish Version of The Axis I Subtests of Coolidge Axis II Inventory Plus (CATI+)

Field: Psychology (Social Sciences)

This study aims to present the psychometric properties of the Turkish version of the AxisI subtests of “Coolidge Axis II Inventory Plus” (CATI+TR-Axis-I).CATI+TR-Axis-I wasadministered to a sample of 1286 participants (59.5 % females, n=765) from various occu-pations, education and age groups living in İstanbul (mean age=33.4, SD=10.83). For testingconvergent validity, Short Symptom Inventory (n=193), Current Symptoms Scale (n=120),Beck Depression Inventory (n=214), and State-Trait Anxiety Inventory (n=193) were alsoemployed. Test-retest reliability was investigated on a group of 52 university students. Cron-bach’s alpha values varied between .59-.88. Test-retest reliabilities were .79-.89. The factoranalysis revealed a two factor structure explaining 81.12 % of the total variance. Convergentvalidities ranged between .52-.77. In terms of discriminant validity, CATI+TR-Axis-I sub-test mean scores differentiated those with and without history of psychiatric help, except for“Withdrawal” subtest.These findings are in line with the original version of the inventoryand can be accepted as a good evidence for its psychometric properties. Although further testsare suggested in various clinical subsamples, CATI+TR-Axis-I is a promising tool for use inresearch in various clinical populations.
Mechanism of control of F-actin cortex architecture by SWAP-70

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ABSTRACT F-actin binding and bundling are crucial to a plethora of cell processes, including morphogenesis, migration, adhesion and many others. SWAP-70 was recently described as an in vitro F-actin-binding and -bundling protein. Fluorescence cross-correlation spectroscopy measurements with purified recombinant SWAP-70 confirmed that it forms stable oligomers that facilitate F-actin bundling. However, it remained unclear how SWAP-70 oligomerization and F-actin binding are controlled in living cells. We addressed this by biophysical approaches, including seFRET, FACS-FRET and FLIM-FRET. PIP3-mediated association with the cytoplasmic membrane and non-phosphorylated Y426 are required for SWAP-70 to dimerize and to bind F-actin. The dimerization region was identified near the C terminus where R546 is required for dimerization and, thus, F-actin bundling. The in vitro and in vivo data presented here reveal the functional relationship between the cytoplasm-to-membrane translocation and dimerization of SWAP-70, and F-actin binding and bundling, and demonstrate that SWAP-70 is a finely controlled modulator of membrane-proximal F-actin dynamics. This article has an associated First Person interview with the first author of the paper.
Data from β<sub>1</sub>-Integrin Circumvents the Antiproliferative Effects of Trastuzumab in Human Epidermal Growth Factor Receptor-2–Positive Breast Cancer

Field: Medicine (Health Sciences)

<div>Abstract<p>Resistance to trastuzumab, the monoclonal antibody targeting human epidermal growth factor receptor 2 (HER-2), is a major concern for HER-2–positive metastatic breast cancer (MBC) patients. To date, HER-2 status is the only available biomarker for selecting patients for trastuzumab-based therapy. β<sub>1</sub>-Integrin, an adhesion molecule involved in cell survival and drug resistance, shares common downstream signaling elements with HER-2, such as the phosphatidylinositol 3-kinase/Akt and extracellular signal-regulated kinase-1/2 (ERK1/2) pathways. The significance of β<sub>1</sub>-integrin expression in HER-2–positive breast cancer and its involvement in a patient's response to trastuzumab-based therapy are unknown. We show here that overexpression of β<sub>1</sub>-integrin is an independent negative prognostic factor for tumor progression of HER-2–positive MBC patients treated with trastuzumab-based chemotherapy. Enforced overexpression of β<sub>1</sub>-integrin, its small interfering RNA–induced knockdown or treatment with a β<sub>1</sub>-integrin–blocking antibody in HER-2–positive breast cancer cells, identified a strong inverse relationship between expression level of β<sub>1</sub>-integrin and <i>in vitro</i> sensitivity to trastuzumab. Notably, β<sub>1</sub>-integrin overexpression increased the phosphorylation of Akt-Ser473 and ERK1/2, thereby promoting survival and mitogenic signals to bypass the antiproliferative effects of trastuzumab. Our findings show that β<sub>1</sub>-integrin provides a novel independent prognostic biomarker of trastuzumab response in HER-2–positive MBC patients and suggest a new target to augment the antiproliferative effects of trastuzumab. [Cancer Res 2009;69(22):8620–8]</p></div>
Review: A Nation of Agents: The American Path to a Modern Self and Society

Field: Arts and Humanities (Social Sciences)

Journal Article Review: A Nation of Agents: The American Path to a Modern Self and Society Get access John F. Wilson John F. Wilson Princeton University Search for other works by this author on: Oxford Academic Google Scholar Journal of the American Academy of Religion, Volume 73, Issue 3, September 2005, Pages 902–905, https://doi.org/10.1093/jaarel/lfi088 Published: 01 September 2005
Extraocular Muscles, Gaze, and Eye Movements

Field: Neuroscience (Life Sciences)

Abstract There are seven extraocular muscles for each eye, six of which are directly attached to the eyeball. The levator muscle of the superior eyelid elevates the upper eyelid, and its lesion causes ptosis. Contraction of other extraocular muscles rotates the eyeball to a specific direction, and separate types of paralysis can be detected by clinical examination. The lateral rectus muscle is innervated by the abducens nerve, the superior oblique muscle is innervated by the trochlear nerve, and the remaining muscles are innervated by the oculomotor nerve. Voluntary movement of both eyes either horizontally or vertically is called gaze. The lateral gaze center is in the pons, and the vertical gaze center is in the midbrain. A lesion of the medial longitudinal fasciculus causes internuclear ophthalmoplegia. There are two kinds of eye movements: saccadic eye movement (saccades) and smooth pursuit eye movement (smooth pursuit), and each system is controlled by different central mechanisms.
The Generation of Evidence in Medicine

Field: Medicine (Health Sciences)

Abstract Federal mandates for comparative effectiveness research enacted during the 2000's are intended to increase the kind of high-quality evidence that doctors and patients need for optimal clinical decision-making. Within the hierarchy of research designs, experimental designs—clinical trials— outweigh non-experimental designs in the ability to provide least-biased estimates that an intervention is likely to provide clinical benefit. Because of steady advances in the methods of clinical trials, we know how to generate high-quality evidence. Yet contemporary medical practice rests on a foundation of shaky scientific evidence. Many clinically-important questions go unstudied, and when they are addressed, research findings are often of dubious validity because weak study designs were used. The utility of syntheses of multiple studies addressing the same clinical question is undermined by variability in the methods and quality across individual studies. Additional funding for comparative effectiveness research will solve some of these problems, but not all.
Optical Coherence Tomography Angiography of the Superficial Microvasculature in the Macular and Peripapillary Areas in Glaucomatous and Healthy Eyes

Field: Medicine (Health Sciences)

Medically managed glaucomatous eyes show sparser superficial microvasculature in the macular area than do healthy eyes. The measurement of the macular superficial vessel density had similar diagnostic accuracy to peripapillary RNFL and macular GCC thickness for differentiating between glaucomatous and healthy eyes.
Children balance theories and evidence in exploration, explanation, and learning.

Field: Psychology (Social Sciences)

We look at the effect of evidence and prior beliefs on exploration, explanation and learning. In Experiment 1, we tested children both with and without differential prior beliefs about balance relationships (Center Theorists, mean: 82 months; Mass Theorists, mean: 89 months; No Theory children, mean: 62 months). Center and Mass Theory children who observed identical evidence explored the block differently depending on their beliefs. When the block was balanced at its geometric center (belief-violating to a Mass Theorist, but belief-consistent to a Center Theorist), Mass Theory children explored the block more, and Center Theory children showed the standard novelty preference; when the block was balanced at the center of mass, the pattern of results reversed. The No Theory children showed a novelty preference regardless of evidence. In Experiments 2 and 3, we follow-up on these findings, showing that both Mass and Center Theorists selectively and differentially appeal to auxiliary variables (e.g., a magnet) to explain evidence only when their beliefs are violated. We also show that children use the data to revise their predictions in the absence of the explanatory auxiliary variable but not in its presence. Taken together, these results suggest that children’s learning is at once conservative and flexible; children integrate evidence, prior beliefs, and competing causal hypotheses in their exploration, explanation, and learning.