jimnoneill/paper-to-field-training huggingface dataset:
Autoimmune Limbic Encephalitis Associated with Glutamic Acid Decarboxylase Antibodies

Field: Medicine (Health Sciences)

Limbic encephalitis (LE) is a clinical syndrome characterized by the progressive development of neuropsychiatric symptoms including personality changes, memory loss followed by seizures, autonomic dysfunction, and involvement of the medial temporal lobes.1 Limbic encephalitis most commonly presents secondary to an autoimmune aetiology which can be further subclassified into autoimmune and paraneoplastic. Autoimmune LE can be classified according to the presence of autoantibodies into two categories. The first one is associated with antibodies to intracellular neuronal antigens and the other with antibodies to cell surface antigens.2 Intracellular antigens include Hu, Ma2, Collapsin response - mediator protein 5 (CRMP - 5) and cell surface antigens like the voltage-gated potassium channel (VGKC), N - methyl - D - aspartate receptor (NMDA) and others. The autoimmune form of LE is important because it can be treated with immunotherapy if detected early. We present a case of a patient with recurrent vertigo followed by progressive cognitive dysfunction and involuntary movements. She was diagnosed with autoimmune limbic encephalitis associated with glutamic acid decarboxylase (GAD) 65 antibodies. Her symptoms showed improvement following immunomodulatory therapy.
Occurrence Download

Field: Agricultural and Biological Sciences (Life Sciences)

A dataset containing 99 species occurrences available in GBIF matching the query: { "and" : [ "Country is China", "HasCoordinate is true", "HasGeospatialIssue is false", "TaxonKey is Neosinocalamus affinis (Rendle) Keng f." ] } The dataset includes 99 records from 3 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0034953-230530130749713/datasets/export for details. Data from some individual datasets included in this download may be licensed under less restrictive terms.
Evaluation on the MUSIC Algorithm Performance of Uniform Rectangular Arrays

Field: Computer Science (Physical Sciences)

Numerous studies for smart antennas with spatial processing to estimate the directions of arrival (DOA) have already been conducted. However, these studies mostly include uniform linear arrays (ULA) and uniform circular arrays (UCA) but not as much effort has been devoted to other configurations, such as uniform rectangular arrays (URA). One of the most popular subspace DOA algorithms is MUSIC algorithm. This paper presents DOA estimation using MUSIC algorithm with uniform rectangular arrays (URA). It also evaluates simulation results of MUSIC algorithm varying the number of antenna elements, the signal-to-noise ratio and the number of samples of the incident signals. Performance improvement in DOA estimation is demonstrated for certain range of input parameters and the results can be used to set the criteria for optimal performance of rectangular smart antennas. In this paper, the performance of DOA estimation with uniform rectangular arrays (URA) and uniform circular arrays (UCA) is also examined and compared.
Immunomorphological Pattern of Molecular Chaperones in Normal and Pathological Thyroid Tissues and Circulating Exosomes: Potential Use in Clinics

Field: Medicine (Health Sciences)

The thyroid is a major component of the endocrine system and its pathology can cause serious diseases, e.g., papillary carcinoma (PC). However, the carcinogenic mechanisms are poorly understood and clinical useful biomarkers are scarce. Therefore, we determined if there are quantitative patterns of molecular chaperones in the tumor tissue and circulating exosomes that may be useful in diagnosis and provide clues on their participation in carcinogenesis. Hsp27, Hsp60, Hsp70, and Hsp90 were quantified by immunohistochemistry in PC, benign goiter (BG), and normal peritumoral tissue (PT). The same chaperones were assessed in plasma exosomes from PC and BG patients before and after ablative surgery, using Western blotting. Hsp27, Hsp60, and Hsp90 were increased in PC in comparison with PT and BG but no differences were found for Hsp70. Similarly, exosomal levels of Hsp27, Hsp60, and Hsp90 were higher in PC than in BG, and those in PC were higher before ablative surgery than after it. Hsp27, Hsp60, and Hsp90 show distinctive quantitative patterns in thyroid tissue and circulating exosomes in PC as compared with BG, suggesting some implication in the carcinogenesis of these chaperones and indicating their potential as biomarkers for clinical applications.
Cystoprostatectomy for Bladder Cancer with Preservation of Potency and No Stoma

Field: Medicine (Health Sciences)

No AccessJournal of Urology1 Jun 1987Cystoprostatectomy for Bladder Cancer with Preservation of Potency and No Stoma N. Javadpour, J.D. Young, and S. KurzweilM.D. N. JavadpourN. Javadpour More articles by this author , J.D. YoungJ.D. Young More articles by this author , and S. KurzweilS. Kurzweil More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)75811-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Cystoprostatectomy for Bladder Cancer with Preservation of Potency and No Stoma." The Journal of Urology, 137(6), p. 269A © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 137 Issue 6 June 1987 Page: 269A Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.Metrics Author Information N. Javadpour More articles by this author J.D. Young More articles by this author S. Kurzweil More articles by this author Expand All Advertisement PDF downloadLoading ...
Seismic Characters of Pore Pressure Due to Smectite-to-illite Transition

Field: Earth and Planetary Sciences (Physical Sciences)

Summary In this study, we strive to understand unloading overpressure caused by smectite-to-illite by using shelf well log data from offshore Louisiana. Two trends of smectite-to-illite transition can be categorized, based on their signatures on the sonic travel time and density crossplot. It corresponds to the cases of fluid expansion and fluid escape during the smectite-to-illite. The fluid expansion can arise high magnitude overpressure and tends to happen when the upper formation has been undercompacted and has less sand content. For the fluid escape case, it has relative deeper overpressure onsets and its overlying formation is less undercompacted and has more sand content. From the synthetic seismic gathers, the two trends of smectite-to-illite have different seismic responses, and can be discerned with AVO technique.
Evaluation of in vitro antioxidant activities of selected commercial tea brands

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The generation of reactive oxygen species requires the availability of antioxidants to ensure a balance between oxidants and prooxidants. Teas are commonly consumed due to their beneficial antioxidant effects. This study evaluated the in vitro antioxidant effects of aqueous and ethanol extracts of five selected commercial tea brands using ascorbic acid as the reference standard. The results showed that total antioxidant capacity (TAC) of aqueous extract of brand 1 was significantly lower (p<0.05) compared to brand 2 with half maximal inhibitory concentration (IC50) values of 96.82 and 25.60 mg/mL respectively while the ethanol extract of all tea brands (IC50 values between 53.94 to 120.40 mg/mL) were significantly lower (p<0.05) to vitamin C with IC50 of 22.72 mg/mL. In the ferric ion reducing antioxidant property (FRAP), four of the tea brands expressed none significant FRAP activities with IC50 values between 12.84 and 14.97 mg/mL compared with vitamin C with IC50 values of 17.16 mg/mL, while the ethanol extract of the brand expressed none significant FRAP activities at higher concentrations. Hydrogen peroxide scavenging activities of aqueous and ethanol extracts of all tea brands were significantly lower (p<0.05) with IC50 values between 20.23 - 44.56 mg/mL and 30.53 - 36.01 mg/mL compared with vitamin C with IC50 values of 13.72 and 15.69 mg/mL respectively. Similarly, 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging property of aqueous extracts of all brands were significantly lower (p<0.05) compared with vitamin C with IC50 values of 12.92 mg/mL. Furthermore, the nitric oxide scavenging property of aqueous extracts of three brands (IC50 = 18.65, 24.69 and 24.80 mg/mL) were significantly higher (p<0.05) than vitamin C (IC50 = 37.75 mg/mL), while ethanol extract of three brands (IC50 = 12.81, 12.84 and 13.89 mg/mL) were significantly higher (p<0.05) than vitamin C (IC50 = 32.80 mg/mL). The results of the study indicated that the selected commercial tea brands possess in vitro antioxidant properties with potential benefits of the removal of free radicals and thus the prevention of oxidative stress.
Treatment patterns, persistence and adherence rates in patients with type 2 diabetes mellitus in Japan: a claims-based cohort study

Field: Medicine (Health Sciences)

Objective To determine real-world trends in antidiabetic drug use, and persistence and adherence, in Japanese patients with type 2 diabetes mellitus (T2DM). Design Retrospective evaluation of administrative claims data (2011–2015) using the Japan Medical Data Center (JMDC) and Medical Data Vision (MDV) databases. Setting Analysis of two administrative claims databases for Japanese patients with T2DM. Participants Adults (aged ≥18 years) with an International Classification of Diseases, 10th Revision code of T2DM and at least one antidiabetic drug prescription. Main outcome measures Treatment patterns in untreated (UT) or previously treated (PT) patients receiving antidiabetic therapy; persistence with treatment at 12 months; adherence to treatment at 12 months. Results 40 908 and 90 421 patients were included from the JMDC and MDV databases, respectively. The most frequently prescribed therapy at the index (first prescription) date was dipeptidyl peptidase-4 inhibitor (DPP-4i) in UT patients (JMDC: 44.0%, MDV: 54.8%) and combination therapy in PT patients (74.6%, 81.1%). Most common combinations were DPP-4i plus: biguanide (BG; 11.4%, 10.9%), sulfonylurea (SU; 8.4%, 11.0%) or BG+SU (7.8%, 9.1%). In UT or PT patients from either database whose index prescription was for any antidiabetic drug class(es) other than DPP-4i, the most frequent add-on or switch was to DPP-4i. 12-month persistence with index monotherapy was highest with DPP-4i and BG. Adherence was high (≥80%) for all monotherapy schedules, except insulin and glucagon-like peptide-1 agonist, and for the five most frequent two-drug and three-drug combinations. Persistence was greater in elderly UT patients and in those receiving ≤5 medications, but comparatively worse in UT patients with ≥3 index antidiabetic drug classes. Conclusions The findings indicate that DPP-4i is the most commonly used antidiabetic drug class in Japanese patients with T2DM, and persistence and adherence to this antidiabetic drug class are high.
Comparison of sixteen continuous-time system identification methods with the contsid toolbox

Field: Computer Science (Physical Sciences)

The performances of sixteen equation error methods for continuous-time system identification are compared through a simulation example with the CONTSID toolbox. The influence of the sampling period, the type of input signal (piece-wise constant or band-limited) and the noise (level and type: white/colored) is studied. The methods are then classed according to quantitative and qualitative criteria.
Reduction of Local Scour Around A Bridge Pier Using Triple Rectangular Plates

Field: Engineering (Physical Sciences)

The performance of vertical triple plates as a new countermeasure in control of local scour around a cylindrical model pier is studied. Two ones of the plates are attached to the side wall one of the pier at one pier diameter distance, extending toward upstream distance and the third one is located in the middle, attached to the pier nose. All the three plates are parallel to flow direction. Experiments are conducted for five different depths of flow and two different lengths of the lateral plates, namely 8 and 14 cm. all the runs are performed under the clear water flow over uniform sediment. The results showed a maximum efficiency of 76% in scour reduction for 8 cm long side plates and 85% for 14 cm long ones.it is also found that the proposed setup act simultaneously as both the bed armoring and flow altering countermeasure.
The Effect of Interruption of Milking on the Carotene and Vitamin A and Proximate Composition of Milk and on the Calcium Content of Blood Serum

Field: Veterinary (Health Sciences)

Summary The effect of interruption of milking for a 10-day period during lactation on the carotene, vitamin A, and proximate composition of milk and on the calcium level of blood serum has been studied for 18 cows. The data indicate that interruption of milking results in significant increases in the concentration of carotene and vitamin A. With the exception of lactose, the proximate constituents also increased in concentration; lactose content decreased. The total amount of these nutrients secreted for the first 3 days after interruption was significantly lower for the proximate constituents, but no appreciable differences were noted for carotene and vitamin A. Interruption of milking, resulted in a significant elevation of blood serum calcium during the period of interruption.
Numerical Study of Soil-Retaining Wall Behavior Subject to Machine Foundations Loads

Field: Engineering (Physical Sciences)

A retaining wall was practically developed to provide lateral support for soil, and it is widely used in underground projects, highway barriers, and mines as well as for aesthetic considerations and slope stabilization. This type of earth structure member can carry machine foundation load simultaneously with traditional static load. This study carried out using the finite element program PLAXIS 3D. The linear elastic model for retaining walls and the Mohr-Coulomb model for soil layers were used in this numerical analysis. The study included three layers of soils under the wall with dry condition. The high of the wall was 4m and the dimensions of machine foundation were 3x3m. It can be concluded that the vertical settlement, horizontal displacement and velocity increased when the duration of the machine load increases. Usually, the horizontal displacement increases to highest value and reached to 10 times the original static value when the machine was closed to the wall with 0.5m and 75Hz. This can be taken into account in the design for such geotechnical system in the design stages.
Familial And Individual Variables Associated With Sport Participation In Portuguese Children

Field: Social Sciences (Social Sciences)

The number of studies focused on children sport participation (SP) correlates is limited. Understanding the familial and individual variables that are associated with children's SP is needed to better understand the individual development of effective intervention strategies to encourage SP. PURPOSE: To examine the association between some selected individual (age, gender, body mass index [BMI] social economic status [SES]) and family (father, mother and siblings SP) variables with the SP among Portuguese children aged 8 to 10. METHODS: A random sample of 683 children students (331 females and 352 males), that attend to 3th to 4th grade of basic education level were surveyed trough the use of a reliable and valid questionnaire previously developed and tested. Children were classified as normal-weight, overweight, or obese using international BMI cut-off points. SES was assessed by the family's annual income. Multivariable logistic regression was used in data analysis. SPSS 17.0 was used in all analyses. RESULTS: (1) Boys were more likely to participate in sports than girls (OR:2.6, 95%CI:1.7-3.9); (2) Children with high SES were more involved in sports (OR:1.7, 95%CI:1.4-2.2); (3) Children were more likely to participate in sports when their siblings also participate (OR:2.5; 95%CI:1.7-3.6); (4) Age was not related to children SP (OR:0.9, 95%CI:0.7-1.1); (5) No significant difference in SP was detected when comparing overweight (OR:1.0, 95%CI:0.6-1.6) and obese (OR:0.9, 95%CI:0.4-1.6) with normal-weight children; (6) Father (OR:1.6, 95%CI:0.8-2.7) and mother (OR:1.7, 95%CI:0.8-3.8) SP were not found to affect the SP of the children. CONCLUSIONS: Family environment and individual variables - in particular gender, SES and siblings' SP - were significantly associated with children SP. These results also suggest that girls and low SES children in Portugal should be targeted for interventions and that siblings should be involved in program modifications. Supported by FCT grant SFRH/BD/42347/2007.
Data from Sequential Intravesical Mitomycin plus Bacillus Calmette–Guérin for Non–Muscle-Invasive Urothelial Bladder Carcinoma: Translational and Phase I Clinical Trial

Field: Medicine (Health Sciences)

<div>Abstract<p><b>Purpose:</b> To determine the safety and toxicities of sequential MMC (mitomycin C) + BCG (bacillus Calmette–Guérin) in patients with non–muscle-invasive bladder cancer (NMIBC) and explore evidence for potentiation of BCG activity by MMC.</p><p><b>Experimental Design:</b> A 3 + 3 phase I dose-escalation trial of six weekly treatments was conducted in patients with NMIBC. MMC (10, 20, or 40 mg) was instilled intravesically for 30 minutes, followed by a 10-minute washout with gentle saline irrigation and then instillation of BCG (half or full strength) for 2 hours. Urine cytokines were monitored and compared with levels in a control cohort receiving BCG only. Murine experiments were carried out as described previously.</p><p><b>Results:</b> Twelve patients completed therapy, including 3 patients receiving full doses. The regimen was well tolerated with no treatment-related dose-limiting toxicities. Urinary frequency and urgency, and fatigue were common. Eleven (91.7%) patients were free of disease at a mean (range) follow-up of 21.4 (8.4–27.0) months. Median posttreatment urine concentrations of IL2, IL8, IL10, and TNFα increased over the 6-week treatment period. A greater increase in posttreatment urinary IL8 during the 6-week period was observed in patients receiving MMC + BCG compared with patients receiving BCG monotherapy. In mice, intravesical MMC + BCG skewed tumor-associated macrophages (TAM) toward a beneficial M1 phenotype.</p><p><b>Conclusions:</b> Instillation of sequential MMC + BCG is safe tolerable up to 40-mg MMC plus full-strength BCG. This approach could provide improved antitumor activity over BCG monotherapy by augmenting beneficial M1 TAMs. <i>Clin Cancer Res; 21(2); 303–11. ©2014 AACR</i>.</p></div>
On the nonlinear Schrödinger equation in spaces of infinite mass and low regularity

Field: Mathematics (Physical Sciences)

We study the nonlinear Schr\\"odinger equation with initial data in\n$\\mathcal{Z}^s_p(\\mathbb{R}^d)=\\dot{H}^s(\\mathbb{R}^d)\\cap L^p(\\mathbb{R}^d)$,\nwhere $0<s<\\min\\{d/2,1\\}$ and $2<p<2d/(d-2s)$. After showing that the linear\nSchr\\"odinger group is well-defined in this space, we prove local\nwell-posedness in the whole range of parameters $s$ and $p$. The precise\nproperties of the solution depend on the relation between the power of the\nnonlinearity and the integrability $p$. Finally, we present a global existence\nresult for the defocusing cubic equation in dimension three for initial data\nwith infinite mass and energy, using a variant of the Fourier truncation\nmethod.\n
Minimal models of $α$-Li$_2$IrO$_3$: On the range of the interactions, ground state properties, and magnetization processes

Field: Physics and Astronomy (Physical Sciences)

In recent years, a lot of effort has been devoted to the quest for experimental realizations of Kitaev interactions in spin systems. Recently, many materials have been synthesized which seem to realize extended Kitaev models, where Kitaev interactions are supplemented by Heisenberg and other bond dependent terms. The crystal and electronic structure of these materials renders the determination of a minimal model a non trivial pursuit. In this work, we will concentrate on one of these particular materials, $α$-Li$_2$IrO$_3$, for which various minimal models have been proposed. Employing large scale Monte Carlo simulations we show how the number of prospective models can be reduced. We study in detail six models with different range of the interactions, and show how only two of those reproduce the most recent experimental results for this material. We obtain two possible minimal models, one of them with nearest neighbour interactions, while the other includes interactions up to third neighbours. Furthermore, we show that strong bond anisotropies and further neighbour interactions are crucial to stabilize the tilted counterotating spirals found in $α$-Li$_2$IrO$_3$. We further clarify the picture, and distinguish these two models by studying the magnetization processes. We predict the magnetization behaviour of these models, and propose future experimental directions.
Trinity and time : an investigation into God's being and his relationship with the created order, with special reference to Karl Barth and Robert W. Jenson

Field: Arts and Humanities (Social Sciences)

It seems that from the inception of western civilization as we know it the question of \nthe nature of our time has been prominent. In fact, Sherover has claimed that “it was concern \nwith the nature of time and change that first provoked the Western development of rational \nthinking about the world…” Thinking about time, though, has experienced the ebb and flow \nof history that is typical of any subject, where at certain epochs the issue was more \nrecognized than at others. Among the many important contributions of twentieth century \nthought has been a renewed interest in the nature of time and the correlate to this \nphenomenon has been the resurgence within Christian thought of the relationship of God and \ntime.
Electronic Contribution to the Dynamical Screening in the Theory of Excitons in III–V and II–VI Semiconductors with Zincblende Structure

Field: Physics and Astronomy (Physical Sciences)

Abstract Starting from the Bethe‐Salpeter equation formulation of Sham and Rice the influence of the dynamical screening in the theory of direct excitons in III–V and II–VI zincblende structure semiconductors is computed taking into account the wave vector dependence of the dielectric constant and higher reciprocal lattice vectors. With the aid of published results of the dielectric constant calculations in the R.P.A. for zincblende semiconductors the influence of the dynamical screening is calculated exactly within the ladder approximation up to the order of magnitude E B / E gap . The results agree with the general statement by Zimmermann that the binding energy should increase due to dynamical screening. Comparison with experiments becomes possible only through the inclusion of some further corrections.