jimnoneill/paper-to-field-training huggingface dataset:
P64 Quality assessment for the continuous bioanalysis of aldosterone: application in an European paediatric study

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background A validation is crucial to ensure the quality of an analytical method and its results. However, the validation is only a first step, further quality assessment has to be utilised to ensure high quality research. Specifications for the validation process, but also for the assessment of data, acquired in a study setting, are given by the EMA and FDA to ensure highest quality of the data. 1 2 Methods A multi-level analytical quality system was established. Data of the calibration standards (CSs), quality control samples (QCs), and incurred sample reanalysis (ISR) were evaluated according to the specifications given by the EMA and FDA guidelines.[1,2] For a run to be considered valid ≥6 levels or 75% of the CSs and 67% of the QCs (≥50% per level) had to vary ≤±20% (LLOQ ≤±25%) from their nominal concentration.[1,2] For the ISR analysis at least 67% of the ISR samples have to lay in ±30% to the nominal concentration of the mean of the original and reanalysed value.[1] Results Seventy analytical runs were conducted, applying the quality measures, 79% runs were classified as valid and were used to determine unknown samples in a paediatric study. The high quality of the acquired data is reflected in the high conformity of the CSs and QCs to the EMA and FDA guidelines, 99% of the CSs and 95% of the QCs were accepted. Further underlining the high quality of the acquired data, 85% of the IRS have also been accepted. The assay was successfully used over a time period of 29 months. Conclusion The results of the quality assessment confirmed the robustness of the aldosterone assay throughout the whole study duration. Thus, the samples measured by this assay are reliable and facilitate the high quality research in the paediatric population. References Guideline on bioanalytical method validation. European Medicines Agency, London, UK (2011). Guidance for Industry: Bioanalytical Method Validation. US Department of Health and Human Services, US FDA Rockville, MD, USA (2018). Disclosure(s) Nina Makowski, Ilja Burdman, Mohsin Ali, Bartel A, Bjoern B. Burckhardt declare that there is no conflict of interest. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007–2013) under grant agreement n°602295 (LENA).
The Effect of Entrepreneurship Orientation and Competitive Advantage to Micro and Small Enterprises of Food and Beverage in Padang City.

Field: Business, Management and Accounting (Social Sciences)

This study aims to reveal how entrepreneurship orientation and competitive advantage affect the performance of micro and small enterprises of food and beverage in Padang City. The type of this research is descriptive and associative research. In this study, the research populations are 694 entrepreneurs of micro and small enterprises of food and beverage in Padang City. The Two Stage Cluster Random Sampling technique is used to determine the sample and the result obtained are 54 people in total. The technique of collecting data is by using questionnaires which are tested first by testing the validity and reliability before being distributed. Data analysis technique used in this study is Path Analysis. The results of this study indicate that entrepreneurship orientation significantly affects competitive advantage, entrepreneurship orientation significantly affects performance of micro and small enterprises, and competitive advantage significantly affects performance of micro and small enterprises.
Disseminated Tuberculosis in a Patient with Chronic Renal Failure

Field: Medicine (Health Sciences)

Patients with chronic renal failure (CRF) are known to be more susceptible to tuberculosis infection due to impairment of the host defense mechanism. Although extrapulmonary tuberculosis is more prevalent in those subjects and it may induce dismal outcome, its diagnosis has been challenging since there is no specific symptoms of the disease and the clinical course is usually atypical. Herein, We report a case of disseminated tuberculosis diagnosed by ultrasound-guided liver biopsy in a 31-year-old CRF patient presenting sustained fever despite broad-spectrum antimicrobial therapy and progressive cholestatic jaundice.
Spiritual Traditions and the Virtues

Field: Arts and Humanities (Social Sciences)

Abstract This book develops a philosophical appreciation of the spiritual life. Specifically, it aims to show how a certain conception of spiritual good, one that is rooted in Thomas Aquinas’s account of infused moral virtue, can generate a distinctive vision of human life and the possibilities for spiritual fulfilment. Among other matters, the text examines the character of the goods to which spiritual traditions are directed; the structure of such traditions, including the connection between their practical and creedal commitments; the relationship between the various vocabularies that are used to describe, from the insider’s perspective, progress in the spiritual life; the significance of tradition as an epistemic category; and the question of what it takes for a spiritual tradition to be handed on from one person to another. So, while the discussion aims to make some contribution to the discipline that we standardly call the philosophy of religion, it has a rather different focus from some familiar ventures in the field, in so far as it starts from a consideration of the nature of spiritual goods and of traditions that seek to cultivate such goods. In his account of the virtues, Aquinas suggests how it is possible for our relations to the everyday world to be folded into our relations to the divine or sacred reality otherwise understood. In this sense, he is offering a vision of how it is possible to live between heaven and earth. This book considers how that vision may be extended across the central domains of human thought and experience, and how it can deepen and diversify our understanding of what it is for a human life to be lived well.
Corynebacterium urogenitale sp. nov. isolated from the genital tract of a cow

Field: Immunology and Microbiology (Life Sciences)

A Gram-stain-positive bacterial isolate, designated LMM-1652 T , was isolated from an intrauterine cytobrush sample originating from a postpartum Holstein Friesian dairy cow. The strain had a rod to coccoid-shape, was catalase-positive and oxidase-negative. 16S rRNA gene sequence similarity analyses revealed that its closest relatives were Corynebacterium falsenii (97.05 % similarity), Corynebacterium jeikeium (96.83 %) and Corynebacterium urealyticum (96.82 %). Subsequent whole genome analysis showed that the genome-to-genome distance of strain LMM-1652 T to its closest relatives was in the range of 23.2–24.8 %, while the average nucleotide identity values ranged from 73.7 to 74.3%, thus confirming that this isolate represents a novel species. Strain LMM-1652 T was characterized by a quinone system mainly consisting of MK-9(H 2 ) and MK-10(H 2 ). The polar lipids profile of the strain consisted mainly of diphosphatidylglycerol, phosphatidylglycerol, phosphatidylinositol and phosphatidylinositol-mannoside, as well as one unidentified lipid lacking any functional group. Smaller amounts of four unidentified phospholipids, four unidentified glycolipids, β-gentiobiosyl diacylglycerol and four unidentified lipids lacking a functional group were also found. The cell wall contained meso -diaminopimelic acid as the diagnostic diamino acid of the peptidoglycan. The fatty acid profile was mainly composed of C 18 : 1 ω9 c , C 18 : 0 and C 16 : 0 . We propose a novel species of the genus Corynebacterium with the name Corynebacterium urogenitale LMM-1652 T (=LMG 31163 T =DSM 108747 T ).
EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries

Field: Medicine (Health Sciences)

The EUROASPIRE III survey shows that large proportions of coronary patients do not achieve the lifestyle, risk factor and therapeutic targets for cardiovascular disease prevention. Wide variations in risk factor prevalences and the use of cardioprotective drug therapies exist between countries. There is still considerable potential throughout Europe to raise standards of preventive care in order to reduce the risk of recurrent disease and death in patients with CHD.
Biogenesis of Yeast Telomerase Depends on the Importin Mtr10

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Telomerase is a ribonucleoprotein particle (RNP) involved in chromosome end replication, but its biogenesis is poorly understood. The RNA component of yeast telomerase (Tlc1) is synthesized as a polyadenylated precursor and then processed to a mature poly(A)- form. We report here that the karyopherin Mtr10p is required for the normal accumulation of mature Tlc1 and its proper localization to the nucleus. Neither TLC1 transcription nor the stability of poly(A)- Tlc1 is significantly affected in mtr10delta cells. Tlc1 was mostly nuclear in a wild-type background, and this localization was not affected by mutations in other telomerase components. Strikingly, in the absence of Mtr10p, Tlc1 was found dispersed throughout the entire cell. Our results are compatible with two alternative models. First, Mtr10p may import a cytoplasmic complex containing Tlc1 and perhaps other components of telomerase, and shuttling of Tlc1 from the nucleus to the cytoplasm and back may be necessary for the biogenesis of telomerase (the "shuttling" model). Second, Mtr10p may be necessary for the nuclear import of some enzyme needed for the nuclear processing and maturation of Tlc1, and in the absence of this maturation, poly(A)+ Tlc1 is aberrantly exported to the cytoplasm (the "processing enzyme" model).
Venous Thromboembolism in a Woman with Diffuse Adenomyosis and Heavy Menstrual Bleeding: Case Report

Field: Medicine (Health Sciences)

This is a case of 41-year-old Filipina, nulligravid with no known comorbidities, admitted due to 1 month history of easy fatigability. Work up revealed acute pulmonary embolism with underlying Protein C deficiency and with concomitant diffuse adenomyosis presenting as abnormal uterine bleeding. The patient was treated with anticoagulation therapy for pulmonary embolism and with GnRH analog for adenomyosis. She was discharged stable and was advised close follow up for monitoring. Pulmonary embolism with concomitant diffuse adenomyosis is uncommon. Few case reports have described the interesting combination of adenomyosis and venous thromboembolism which poses a challenging management dilemma. In this patient with underlying protein C deficiency who presented with pulmonary embolism and deep vein thrombosis, the appropriate management is the use of anticoagulation. However, considering that the patient was also diagnosed of diffuse adenomyosis and concomitant abnormal uterine bleeding, anticoagulation may worsen the patient’s bleeding and anemia. Treatment of adenomyosis using combined oral contraceptive pills would aggravate thromboembolism and vice versa. This patient was managed successfully using a multidisciplinary approach with anticoagulation and GnRH analog injection with no adverse event noted. In conclusion, occurrence of venous thromboembolism in patients with adenomyosis is uncommon, however can be managed successfully with a multidisciplinary approach and careful planning. Management of these patients present with great challenges and requires timely intervention, including meticulous follow-up strategies after pulmonary embolism to prevent recurrence and untoward side effects of treatment regimen.
Skeletons in Hunter’s Closet: James Douglas and the Fashioning of William Hunter

Field: Arts and Humanities (Social Sciences)

Skeletons in Hunter's Closet: James Douglas and the Fashioning of William HunterNathan FlisWilliam Hunter and the Anatomy of the Modern MuseumIt might be said that William Hunter preserved the remains of his teacher and mentor James Douglas, MD, FRS (1675–1742), a fellow Scot who served as Physician Extraordinary to Queen Caroline. While Douglas's body was interred at the church of St Andrew's, Holborn, the rest of his physical legacy is held mainly among Hunter's collections at the University of Glasgow, which reveal that the protégé kept an astonishing number of the master's possessions: a profusion of papers,The Douglas papers are now part of the Archives and Special Collections at the University of Glasgow Library. They first came to light in 1908, when they were housed in the Blackburn Cabinet at the Hunterian Museum; see John Young and P. H. Aitken, A Catalogue of the MSS in the Library of the Hunterian Museum in the University of Glasgow (Glasgow: MacLehose & Sons, 1908). The papers were subsequently catalogued by K. Bryn Thomas in James Douglas of the Pouch and His Pupil William Hunter (London: Pitman Medical PublishAuthorNathan FlisPublisherYale Center for British ArtCopyright© 2018 Yale UniversityRelated print edition pages: pp.49-71 https://doi.org/10.37862/aaeportal.00250.003 Stable URL: https://www.aaeportal.com/?id=-21201Copy Chapter subject tags:Hunter, William, 1718-1784Douglas, James, 1675-1742ApprenticesHuman anatomyZoology
Throughlines

Field: Arts and Humanities (Social Sciences)

Six months ago, the Louvre opened a new art museum in Abu Dhabi. The museum's central theme is universality. When you see art from entirely different cultural traditions displayed side by side, you see striking similarities that in a traditional museum would be less obvious. Three gold funerary masks from the Levant, China, and Peru. In a small, dark room, side by side, illuminated pages of the Koran, Bible, and Torah. To help all kids thrive, we, too, must look past superficial differences in origin and focus instead on universal psychological insights. We must find the throughlines. Imagine, for example, if I had to fashion an exhibit out of what I happen to be carrying around in my backpack. In a waist-high glass case, on a red velvet cloth, under three tiny halogen lights, I'd lay two books and one manuscript.
Comparative studies of pulsed and sinusoidaldielectric-barrier discharges in atmospheric N<inf>2</inf>

Field: Physics and Astronomy (Physical Sciences)

Summary form only given. Many experimental and theoretical studies show that the shape of excitation voltage waveform is a crucial factor in generating uniform atmospheric-pressure plasmas 1–4 . In this paper, we compare the characteristic of pulsed and sinusoidal dielectric-barrier discharges (DBDs) in atmospheric N 2 by numerical simulations based on a one-dimensional fluid model. The results show that, different from the sinusoidal atmospheric nitrogen discharges which usually operate in Townsend discharge mode, the pulsed atmospheric nitrogen discharge can exist in two different modes, namely glow mode and Townsend mode depending on the rise time of the applied voltage pulse. Under the same voltage amplitude, when the rise time is longer, the discharge operates in Townsend mode, otherwise glow discharge occurs. In the Townsend discharge mode, the density of N 2 + is some orders of magnitude lower than that of N 4 + , but is much higher than N 4 + density in the glow mode, implying the penning ionizations between two metastable molecules play a dominate role in Townsend discharge, whereas the direct ionization of N 2 by electron impact is the primary ionization mechanism in the glow discharge. The effects of other parameters (such as pulse width, frequency, etc.) on the behaviors of pulsed DBD in atmospheric N 2 are also studied. In addition, the pulsed nitrogen discharge with multiple current peaks during the rise phase of the applied voltage pulse are also discussed and analyzed. For many practical applications, the atmospheric nitrogen plasma is more attractive due to its low cost and active reaction chemistry, and therefore, the detailed study of N 2 atmospheric DBDs under different electrical excitation is very necessary.
Design Accessible Web Sites: 36 Keys to Creating Content for All Audiences and Platforms

Field: Computer Science (Physical Sciences)

It's not a one-browser web anymore. You need to reach audiences that use cell phones, PDAs, game consoles, or other browsers, as well as users with disabilities. Legal requirements for assistive technologies as well as a wide array of new browsing experiences means you need to concentrate on semantics, alternate access paths, and progressive enhancement. Give your audience the power to interact with your content on their own terms. It's the right thing to do, and with a $100 billion a year market for accessible content, new laws and new technologies, you can't afford to ignore accessibility. With this book, you'll learn basic principles and techniques for developing accessible HTML, audio, video, and multimedia content. In addition, you will understand how to apply the principles you learn in this book to new technologies when they emerge. You'll learn how to: Use best practices of accessibility to develop accessible web content Build testing into projects to improve results and reduce costs Create high quality alternative representations for your audience Add accessibility features to external media like PDF and Flash Negotiate the terrain of accessibility standards Apply principles of accessiblity to new technologies as they emerge
Family Amaranthaceae Juss. in Communities of Saline Soils in Southeastern Europe

Field: Agricultural and Biological Sciences (Life Sciences)

Data on the way of invasion of representatives of the family Amaranthaceae Juss. into plant communities of saline habitats of Southeastern Europe—participation in formation of cenoses, distribution, and ecological features of habitats—are given. Only two North American species of this family—Amaranthus albus L. and A. retroflexus L.—are revealed in the specified ecotopes. They obviously cannot exert a considerable impact on communities, because they are not abundant and their occurrence there is low.
CHARACTERIZATION OF THE AUXIN SYNTHESIS GENES OF ERWINIA HERBICOLA PV. GYPSOPHILAE

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

We present the DNA sequence of some 3590 base pairs from the virulence plasmid of the crown-gall-forming bacterium Erwinia herbicola pv. gypsophilae strain PD713. This region includes the entire transcription unit of an operon encompassing the IAA synthesis genes. These genes, designated iaaM and iaaH , reside on a 78-MDa native plasmid. The sequence analysis indicates that the operon contains two open reading frames of 562 ( iaaM ) and 460 amino acids ( iaaH ), corresponding to proteins with molecular weight of 62,473 and 49,300 daltons, respectively. When cloned and expressed in minicell-producing E. coli , this sequence encodes production of two proteins, 49 and 62 kDa. Both genes show moderate to high homology to IAA synthesis genes from other plant-associated bacteria. Analysis by primer extension of the transcription initiation site located it 63 bases upstream of the translation initiation codon.
DOI: 10.3346/jkms.2008.23.2.176 Copyright � The Korean Academy of Medical Sciences Cost-Benefit Analysis of Haemophilus Influenzae Type B Immunization

Field: Health Professions (Health Sciences)

An economic evaluation of Haemophilus influenzae type b (Hib) immunization was conducted to examine whether Hib immunization should be included in the Korea’s national immunization program. The costs and benefits included direct and indirect values and an estimation of the economic efficiency. We determined that a universal Hib immunization program in Korea would prevent 17 deaths and 280 invasive Hib cases. When we assumed the one Hib immunization cost as 26,000 won, the national Hib immunization would cost 34.6 billion won. Costs for various Hib diseases were estimated at 26.8 billion won (11.8 billion won from direct costs and 14.9 billion won from indirect costs). A benefit-cost ratio of 0.77 showed that the economic efficiency of the integration of Hib immunization in Korea is low because of the low incidence rate of Hib disease and high price of vaccine. However, if the Hib immunization cost decrease to less than 20,000 won, a benefit-cost ratio increase to 1.0 and above, integrating Hib immunization into the national immunization program with economic efficiency can be considered.
Comparative Changes in the Serum Concentrations of Inhibin-B, Prolactin, Gonadotropins and Steroid Hormones at Different Reproductive States in Domestic Turkey Hens

Field: Veterinary (Health Sciences)

The present study was undertaken to compare the changes in circulating levels of inhibin-B, prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol-17beta, progesterone and testosterone during the different reproductive states of turkey hens. Blood samples were collected during different reproductive states, at laying, incubating and out of lay. Inhibin-B was measured by ELISA, while other hormones were determined by Chemiluminescent Microparticle Immunoassay (CMIA). The results revealed highly significant differences among the hen's states for all serum hormone concentrations. The highest levels of inhibin-B and prolactin were observed in incubating hens, while the lowest values were observed in laying hens. In contrast, the highest levels of FSH, LH, estradiol-17beta, progesterone and testosterone were found in the laying group, while the lowest values were found in the incubating group. The progesterone level was higher in the laying group compared with the other groups. These results clearly demonstrate that negative correlation was found between both the inhibin-B and prolactin levels and the gonadotropin and steroid hormone concentrations during the different reproductive states of the turkey hens. In addition, the results suggest that inhibin-B may be involved in control of FSH and LH secretion.
Comment on Fermionic and Bosonic Pair-creation in an External Electric Field at Finite Temperature

Field: Physics and Astronomy (Physical Sciences)

We show that contrary to the claim made by Hallin and Liljenberg in Phys. Rev. D52 1150,(1995), (hep-th/9412188) the thermal correction to the thermal decay or pair production rate for a system placed in a heat bath in the presence of an external electric field, is always nonzero in the finite as well as infinite time limit. Using the formalism outlined there, we reestimate the decay rate for different values of temperature, mass and time.We also try to identify the parameter ranges where the quantity of interest agrees with that computed previously, at high temperature (in the infinite time limit), from the imaginary part of the effective action using imaginary time and real time formalism of thermal field theory. We also point out that in the strictly infinite time limit, the correct decay rate as obtained from the work of Hallin et. al. tends to diverge.
eFigure5 from Tumor Mutational Burden and <i>PTEN</i> Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer

Field: Medicine (Health Sciences)

<p>Kaplan-Meier curves for overall survival for high TMB {greater than or equal to}7 and {greater than or equal to}10 mutations/Mb and PTEN alterations in non-ICI-treated mTNBC. Overall survival by (A) tumor mutational burden <7 vs. {greater than or equal to}7 mutations/megabase; (B) tumor mutational burden <10 vs. {greater than or equal to}10 mutations/megabase, and (C) PTEN alteration (absent vs. present).</p>