jimnoneill/paper-to-field-training huggingface dataset:
Feminist Family Therapy for Treating Female Survivors of Childhood Sexual Abuse

Field: Psychology (Social Sciences)

Female survivors of childhood sexual abuse make up a population that warrants special clinical attention. Despite the amount of literature devoted to childhood sexual abuse, little attention has been paid to the culture of the individual survivor and her family in the field of couple and family therapy. There are unique aspects about women’s experiences with childhood sexual abuse that require attention to gender and cultural issues. To attend to this identified gap, an overview of some of the common problem areas that survivors and their families experience is provided, and feminist family therapy is discussed as a suggested treatment approach.
Paraplegia Due to Paget's Disease (Osteitis Deformans)

Field: Medicine (Health Sciences)

Osteitis deformans, or Paget's disease, may affect any part of the skeleton in those of older years.While involvement of the spinal column is frequent, it is unusual for compression of the spinal cord to be produced.It is probable that this complication is com- moner than the literature would indicate, as it occurs in an age group in which accurate assessments of the nervous system are rarely made.Two cases are described and their relationship to the usual pattern of the disease discussed.Case 1 A woman aged 64 was admitted to Dunedin Hospital on January 21, 1952.Three and a half years ago she had begun to notice a nagging pain in the small of her back.This was followed by increasing pain in the hips and knees.About a year ago she had had burning pains in both legs, and her feet had felt numb and lifeless.Walking had become difficult, and eventually she had had to use two sticks.For a year her balance had been bad and she had I am grateful to Dr. John Willis, of Palmerston North, for referring Case 1 and to Dr.
Polyphenol Composition of Extracts of the Fruits of Laserpitium Krapffii Crantz and Their Antioxidant and Cytotoxic Activity

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

During inflammation, reactive oxygen species (ROS) are produced in large amounts, causing oxidative stress. Several studies confirm that plant extracts rich in phenolic compounds may inhibit ROS production. For that reason, the aim of this work is the qualitative and quantitative analysis of phenolic acids and flavonoids in the etheric (LAEN) and methanolic (LAM) extracts of the fruits of Laserpitium krapffii Crantz, as well as their antioxidative and cytotoxic properties. Liquid chromatography–electrospray tandem mass spectroscopy (LC-ESI-MS/MS) enabled the identification of 12 phenolic acids and nine flavonoids. Both tested extracts scavenged ROS in a concentration-dependent manner. Stronger activity was observed for the methanolic extract. The cytotoxic effect of both extracts in increasing concentrations on five types of cancer cell lines was also investigated. The cytotoxicity was estimated using trypan blue vital staining. It was found that the analyzed extracts induced the apoptosis of the cells of all the tested cell lines. In conclusion, our results present that the fruits of L. krapffii can be a source of valuable compounds with protective effects against oxidative damage.
DEK gene expression in the human CRC cell line SW-620 after RNAi.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>(A) Nuclear localization of DEK protein is observed in siControl and siDEK SW-620 cells. DEK (red) localized to the SW-620 cell nuclei by immunofluorescence staining and confocal microscopy observation. DAPI staining (blue) was included to visualize the nucleus. (B) DEK mRNA expression in the human CRC cell line SW-620 after siControl and siDEK. (C) DEK protein expression in the human CRC cell line SW-620 after siControl and siDEK.</p>
Identification of Multiple Proteins That Interact with Functional Regions of the Human Cardiac α-Actin Promoter

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

5' Sequences of the human cardiac alpha-actin gene are involved in the tissue-specific and developmental regulation of the gene. Deletion analyses combined with transient expression experiments in muscle cells have demonstrated three primary regions of functional importance (A. Minty and L. Kedes, Mol. Cell. Biol. 6:2125-2136, 1986; T. Miwa and L. Kedes, Mol. Cell. Biol. 7:2803-2813, 1987), and we have previously demonstrated binding of a protein indistinguishable from serum response factor (SRF) to the most proximal region (T.A. Gustafson, T. Miwa, L.M. Boxer, and L. Kedes, Mol. Cell. Biol. 8:4110-4119, 1988). In this report, we examine protein interaction with the remainder of the promoter. Gel shift and footprinting assays revealed that at least seven distinct nuclear proteins interacted with known and putative regulatory regions of the promoter. The transcription factor Sp1 bound to eight sites, as demonstrated by footprinting assays and gel shift analysis with purified Sp1. Purified CCAAT box-binding transcription factor CTF/NF-I and Sp1 were shown to interact with the far-upstream regulatory element at -410, and footprint analysis showed extensive overlap of these two sites. Two unidentified proteins with similar but distinct footprints interacted with the second region of functional importance at -140, which contains the second CArG motif [CC(A + T rich)6GG], and these proteins were shown to be distinct from SRF. SRF was found to bind to the remaining three CArG boxes, two of which were closely interdigitated with Sp1 sites. In addition, CArG box 4 was found to interact with SRF and another distinct protein whose footprint was contained within the SRF-binding site. Sequences surrounding the TATA box were also shown to bind proteins. Sp1 was shown to bind to a site immediately downstream from the TATA box and to a site within the first exon. Thus, each of the three functional upstream regions, as defined by transfection assays, was shown to interact with five factors: Sp1 and CTF/NF-I at the upstream site, two unidentified proteins at the central site, and SRF at the most proximal site. These results suggest that expression of the cardiac actin gene in muscle cells is controlled by complex interactions among multiple upstream and intragenic elements.
Liquid biopsy for liver diseases

Field: Medicine (Health Sciences)

With the growing number of novel therapeutic approaches for liver diseases, significant research efforts have been devoted to the development of liquid biopsy tools for precision medicine. This can be defined as non-invasive reliable biomarkers that can supplement and eventually replace the invasive liver biopsy for diagnosis, disease stratification and monitoring of response to therapeutic interventions. Similarly, detection of liver cancer at an earlier stage of the disease, potentially susceptible to curative resection, can be critical to improve patient survival. Circulating extracellular vesicles, nucleic acids (DNA and RNA) and tumour cells have emerged as attractive liquid biopsy candidates because they fulfil many of the key characteristics of an ideal biomarker. In this review, we summarise the currently available information regarding these promising and potential transformative tools, as well as the issues still needed to be addressed for adopting various liquid biopsy approaches into clinical practice. These studies may pave the way to the development of a new generation of reliable, mechanism-based disease biomarkers.
Guerrillera Editorship enacts the decolonial imaginary of Chicana editors

Field: Arts and Humanities (Social Sciences)

This project examines the editorial practices of former Chicana editors of a bilingual, alternative, activist Chicana/Chicano college student newspaper, mapping out the ways Chicana feminist epistemologies shaped their editorial praxis. Grounded in the decolonial imaginary of seven Chicanas, we identify a praxis we call Guerrillera Editorship in which Chicana editors integrate their leadership, advocacy, and written work within a muxerista orientation in order to work communally to honor the testimonio of contributors, strive towards social justice, and draw attention to Chicana issues. This work enhances an existing scholarly record that analyzes the rhetoric of Chicana feminists, but lacks an analysis of Chicana-led media production. By contextualizing the efforts of these contemporary Chicana cultural workers within the history of Chicana feminist print media, and drawing on Chicana feminist theories to guide the methodology and analysis of this project, we offer a Chicana-centered editorial activism whose decolonial underpinnings counter masculinist leadership styles and offset mainstream editorial practices.
Sweetening the pot in muscle

Field: Medicine (Health Sciences)

Three papers in this issue of Neurology 1-3⇓⇓ and one that appeared 3 months ago4 report patients with newly discovered diseases of protein glycosylation. Glycosylation is a post-translational modification of proteins to form glycoproteins, which serve crucial roles in function such as mediating cell adhesion and signaling, as well as being the backbone of basal lamina.5 Glycosylation takes place in the Golgi apparatus by the sequential attachment and removal of oligosaccharide moieties or glycans (including mannose, galactose, fucose, N-acetylglucosamine, N-acetyl galactosamine, and sialic acid). Glycoproteins have been classified as N-linked or O-linked.5 In N-linked glycoproteins the glycan moiety is linked, via N-acetylglucosamine, to the amide group of an asparagine residue of the protein.6 In the most abundant form of O-linked glycoproteins the glycan is linked, via N-acetylgalactosamine to the hydroxyl group of either serine or threonine of the protein.5 Recently, however, other types of O-glycosylation have been described in mammals, including O-mannosylation, in which the glycan moiety is linked, via mannose, to the hydroxyl group of either serine or threonine.7 O-mannosyl types of glycoproteins are of particular importance for skeletal muscle because a key sarcolemmal glycoprotein, α-dystroglycan, important in the pathogenesis of many muscular dystrophies, belongs in this category.8

A disturbed glycosylation profile of proteins may be a result of nonspecific cellular pathology, but in the past 3 years many diseases have been discovered to be caused by a primary genetic defect that disrupts the normal glycosylation pattern of proteins. Glycosylation defects may occur as a result of a deficient …
Inflammation and airway microbiota during cystic fibrosis pulmonary exacerbations. PLoS One 2013

Field: Medicine (Health Sciences)

Background: Pulmonary exacerbations (PEx), frequently associated with airway infection and inflammation, are the leading cause of morbidity in cystic fibrosis (CF). Molecular microbiologic approaches detect complex microbiota from CF airway samples taken during PEx. The relationship between airway microbiota, inflammation, and lung function during CF PEx is not well understood. Objective: To determine the relationships between airway microbiota, inflammation, and lung function in CF subjects treated for PEx. Methods: Expectorated sputum and blood were collected and lung function testing performed in CF subjects during early (0–3d.) and late treatment (.7d.) for PEx. Sputum was analyzed by culture, pyrosequencing of 16S rRNA amplicons, and quantitative PCR for total and specific bacteria. Sputum IL-8 and neutrophil elastase (NE); and circulating C-reactive protein (CRP) were measured. Results: Thirty-seven sputum samples were collected from 21 CF subjects. At early treatment, lower diversity was associated with high relative abundance (RA) of Pseudomonas (r =20.67, p,0.001), decreased FEV1 % predicted (r = 0.49, p = 0.03) and increased CRP (r =20.58, p = 0.01). In contrast to Pseudomonas, obligate and facultative anaerobic genera were associated with less inflammation and higher FEV1. With treatment, Pseudomonas RA and P. aeruginosa by qPCR decreased while
Design and development of sensorless based 5-DOF bilaterally controlled surgical manipulator: A prototype

Field: Engineering (Physical Sciences)

Minimally invasive surgery (MIS) is one of the most challenging tasks in surgical procedures due to the lack of visibility of the surgical area, instrument orientation, and depth perception. A tele-operated robot assisted minimally invasive surgery is developed to enhance a surgeon's hand dexterity and accuracy. To perform MIS, the surgeon controls a slave manipulator via a master manipulator, so the force feedback and motion feedback are required to imitate an amount of action and reaction force between master and slave manipulator. The complicated MIS requires more complex surgical manipulator with multi DOFs and multiple force feedback. The limitation of multiple DOFs force feedback is a bandwidth of torque sensors. Therefore, this study proposes a sensorless based 5-DOF Bilaterally controlled surgical manipulation. In this research disturbance observer (DOB) is used to identify the internal disturbance of the system, which is used to estimate the reaction torque. This research mainly focuses on a 5-DOF bilaterally controlled surgical manipulator to maintain a position and additional force. The result of torque error in contact motion is less than 2%, the non-contact motion error is not over 5%, and it is evident that the error is always less than 0.3% for the position response.
Post‐Soviet political culture in Russia: An assessment of recent empirical investigations

Field: Social Sciences (Social Sciences)

AT A TIME WHEN THE WORLD SEEMS HEADED toward 'the clash of civilisations' and 'the great divisions among humankind and the dominating source of conflict will be cultural',1 we must make renewed efforts to comprehend the significance of cultural factors for politics in the countries of the former Soviet Union. The concept 'political culture' has been much used and abused in the study of Soviet politics in recent decades. Some attempts were made 25 years ago to bring rigour to the concept by linking the study of political culture in communist countries to the works of anthropologists and political scientists.2 While this early effort at bridge-building between area and discipline proved to be both interesting and stimulating of new ideas and approaches, its promise in Soviet studies could not be realised in the absence of systematic empirical data to test hypotheses. The best that could be done under the circumstances was to rely heavily on interviews with Soviet emigres.3 Initial optimism about use of the political culture concept gave rise in the 1980s to infighting and soul-searching.4 The new data-rich environment of the post-Soviet era challenges us to test theories that heretofore have lain dormant because of 'obstacles to direct observation' that forced scholars to practice anthropology from afar or to engage in flights of fancy through historical extrapolation.5 This article examines the strengths and weaknesses of some recent empirical research on post-Soviet political culture in Russia in order to strengthen further bridge-building efforts to the benefit of both social science and post-Sovietology.6
CHUKWUMA NZEOGWU IN THE THROES OF CONTEMPORARY NIGERIAN HISTORY

Field: Social Sciences (Social Sciences)

For the greater part of its existence as a sovereign state, Nigeria has witnessed more years of military than civilian rule. An excursion into this very important aspect of our national history must, of necessity, interrogate the circumstances and dramatis personae that led to the military’s intervention in national politics. One name that has never escaped the scrutiny in this effort is that of Major Chukwuma Kaduna Nzeogwu. Though a posthumous research, the intention of this paper is to attempt a reappraisal of the often ignored, misinterpreted and maligned intentions of the principal actors of the January 15, 1966 military coup d’etat, especially the role of Nzeogwu. In order to achieve this objective, the research made use of both primary and secondary sources of data. These were subjected to initial qualitative analysis. The research concludes that part of the reasons for the misinterpretation of Nzeogwu’s role is the need to justify the failure of the government of the First Republic to satisfy the basic human and material needs of Nigeria. In addition, it establishes the fact that subsequent political equations and configurations in Nigeria have evidently been to the benefit of those who have been at pains to justify the brutality that attended the January 1966 coup d’etat.
Image Gallery: Necrolytic migratory erythema associated with glucagonoma

Field: Medicine (Health Sciences)

Funding sources: no external funding. Conflicts of interest: none to declare. Dear Editor, A 57‐year‐old man with diabetes presented with a 30‐year period of pruritic skin lesions concurrent with a 12‐kg loss of weight. The lesions presented as generalized arciform, erythematous and eroded plaques with overlying haemorrhagic crust (a). There was associated angular cheilitis and atrophic glossitis (b). The skin biopsy showed three structures within the epidermis: a layer with basaloid keratinocytes, a spiny zone with cleared cytoplasm cells and another part with thickened eosinophilic stratum corneum, suggestive of necrolytic migratory erythema (c). An abdominal computed tomography scan found a pancreatic mass and liver metastases whose biopsy revealed infiltration by a neuroendocrine tumour with glucagon immunoexpression. Plasma glucagon was increased. The skin lesions resolved following treatment with somatostatin analogues.
Clinical outcomes and prognosis after thoracoscopic esophagectomy with two-field lymph node dissection for lower thoracic esophageal cancer.

Field: Medicine (Health Sciences)

Thoracoscopic esophagectomy with two-field lymph node dissection is a safe and appropriate surgical intervention for patients with lower thoracic esophageal cancer without complication of lymph node metastases to the upper mediastinum and/or celiac area.
Students’ Need Analysis Of English Subject At Elementary School In Kabupaten Lima Puluh Kota

Field: Arts and Humanities (Social Sciences)

Need analysis is a specific ground for finding information about learners basic needs in accordance with the priority of learning a particular language to develop students’ knowledge and skills in language learning. This research aims to investigate students’ need on English subject at Elementary school in Kabupaten Lima Puluh Kota. The researcher used descriptive qualitative method. The research subject are the teachers and parents from grade 4and 5 at elementary school students’. A set of questionnaire and interview are distributed to get the data. In analyzing the data, the researcher used the steps, there are: data managing, reading/memoing, classifying, interpreting and writing report. The findings indicate that 91,26% of the participant agree that is needed to be taught English subject at elementary school in Kabupaten Lima Puluh Kota. While 97,57% of the teachers stated that target need is needed to teach English subject at elementary school and 86,55% of the teachers stated that learning need is needed to teach English subject at elementary school. Supported by the result of interview with the teachers, the researcher found that target need is necessary to teach English subjet at elementary school to continue students in junior high school later. The teachers stated that learning need is needed to be taught vocabulary with English basic material such as alphabet, objects, part of body and colors. The teachers also stated that it is necessary using interested strategy such as games and medias, for example pictures, guessing pictures and puzzle. Then the researcher found 94,52% of the parents stated that target need is needed to teach English subject at elementary school and 86,41% stated that learning need is needed to teach English subject at elementary school.
A first attempt to use a Fusarium subglutinans culture filtrate for the selection of pineapple cultivars resistant to fusariose disease

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Pineapple, Ananas comosus L. Merr., cultivars differing in resistance to fusariose were examined for the phytotoxic effect of culture nitrate (CF), and fusaric acid (FA) isolated from Fusarium subglutinans (Wollew & Reinking) Nelson, Toussoun & Marasas. The possibility of using these substances on F 1 hybrids as selection agents for resistance was also evaluated. The phytotoxic effect of these substances was assessed in pineapple plantlets from tissue culture by placing them on wounded leaf segments. The resistance level of the F 1 hybrids and cultivars under natural conditions was measured in greenhouse field tests. The susceptible cultivars proved to be the most sensitive in each test, whereas resistant cultivars showed resistance to CF. FA affected all the cultivars independently of the degree of resistance of the cultivars The presence of other metabolites in CF was responsible for the screening effect between the varieties. Using CF as selection criteria allowed the selection of resistant plants with behaviour quite similar to plants where the fungus itself was used as the selection agent.
Morphological Analysis of Proximal Femurs in 219 Hip Resurfacing Arthroplasty Patients

Field: Medicine (Health Sciences)

Hip resurfacing arthroplasty (HRA) is a type of hip replacement that removes minimal femoral bone stock and is most common in patients under 65 years of age. HRA patient outcomes can be improved with the use of preoperative planning. Preoperative planning is multifaceted and relies on joint morphology, applied loading, and material properties. These facets also interact in that morphology impacts loading, which impacts material properties and implant performance. Preoperative planning traditionally uses planar radiographs to measure morphology; however, using three-dimensional (3D) modalities could improve measurement accuracy. Sex impacts bone morphology, material properties, and loading; it is important that anthropometric data be disaggregated by sex, and sex-based analyses be conducted. This thesis aimed to design a 3D workflow to quantify and summarize the affects of proximal femur morphology on HRA patient outcomes. This study used the preoperative computed tomography (CT) scans and postoperative bloodwork of 219 HRA patients (202 males and 17 females) from the Kingston Health Sciences Centre dataset (ethics protocol SCOMP-007-11). A semi-automated workflow was designed and verified to quantify patient specific proximal femur morphology using 3D surface geometry from preoperative CT scans in HRA recipients. The proximal femur morphological parameters were measured due to their relevance in joint loading. Proximal femur morphological measurements were determined and summarized by both sex and affected side. Morphological measurements were compared to plasma cobalt and chromium ion rates, as they are used to quantify implant wear and failure. There is currently no workflow that quantifies mechanically motivated 3D proximal femur morphological parameters. This thesis proposes a novel methodology for assessing 3D proximal femur morphology, which can be used in combination with bone material properties and applied joint loading assessments for HRA preoperative planning.