jimnoneill/paper-to-field-training huggingface dataset:
THE EVALUATION OF THE PARTICIPATION OF GAME AND PHYSICAL EDUCATION LESSON OF THE MILD SEVERE DEGREE MENTAL RETARDATION AND AUTISTIC STUDENTS

Field: Social Sciences (Social Sciences)

The aim of this research is to evaluate the acquisition of mild degree mentally disabled students; severe degree mentally disabled students and autistic students in game and physical activities and physical education lessons. The research was done to describe current situation. Nineteen special education teachers and one physical education teacher joined the research voluntarily. Teacher’s evaluated 44 mild degrees mentally disabled students, 31 severe mentally disabled students and 10 autistic students with the evaluation form of game and physical activities. Descriptive statistic techniques were used during the data analysis. According to research result, 1st-2nd-3rd class mild degree mentally disabled students, gallop skill should be developed and also severe degree mentally disabled one in mild level. It was seen that students one in sufficient level. Teachers gave the idea that 4th grade mentally disabled students should the skill of kicking the ball with a racked, folk dances, creative / cultural dances, designing a game, developing a programme and preparing a demonstration they are evaluated as middle and good in jumping, taking step and jumping and joining the game. But in other skills, they are evaluated as good and very good. It is resulted that 4th grade severe degree mentally disabled students are good and very good in running, jumping, hitting, throwing and catching skills; creative/cultural designing a game, developing programes, preparing a demonstration should be developed. As a result, in the movements that were requiring object control, creative, cultural dances, designing a game, developing a program, preparing a demonstration, joining game skills should be developed. Article visualizations:
Characterization of a Defensin from the Sand Fly Phlebotomus duboscqi Induced by Challenge with Bacteria or the Protozoan Parasite Leishmania major

Field: Immunology and Microbiology (Life Sciences)

ABSTRACT Antimicrobial peptides are major components of the innate immune response of epithelial cells. In insect vectors, these peptides may play a role in the control of gut pathogens. We have analyzed antimicrobial peptides produced by the sand fly Phlebotomus duboscqi , after challenge by injected bacteria or feeding with bacteria or the protozoan parasite Leishmania major . A new hemolymph peptide with antimicrobial activity was identified and shown to be a member of the insect defensin family. Interestingly, this defensin exhibits an antiparasitic activity against the promastigote forms of L. major , which reside normally within the sand fly midgut. P. duboscqi defensin could be induced by both hemolymph or gut infections. Defensin mRNA was induced following infection by wild-type L. major , and this induction was much less following infections with L. major knockout mutants that survive poorly in sand flies, due to specific deficiencies in abundant cell surface glycoconjugates containing phosphoglycans (including lipophosphoglycan). The ability of gut pathogens to induce gut as well as fat body expression of defensin raises the possibility that this antimicrobial peptide might play a key role in the development of parasitic infections.
Effect of Applying Cold Gel Pack to the Sternum Region on the Postoperative Pain after Open-Heart Surgery

Field: Nursing (Health Sciences)

Aim:The present study was performed atinvestigating the effects of cold gel pack applied to the sternum on the pain associatedwith deep breathing and coughing after open-heart surgery.Material-Methods: The studysample included 46 participants. While the study data were collected, the“Patient Information Form” prepared by the researcher based on the pertinentliterature was used to question the sociodemographic characteristics of thepatients, the “Visual Analogue Scale-VAS” was used to assess the severity of thepatient&#039;s pain, and the “Pain Monitoring Form” was used to record the patient&#039;spain associated with deep breathing and coughing exercises before and aftercold gel pack application. Pain scores after deepbreathing and coughing were measured and compared warm (roomtemperature) (placebo) gel pack, with (intervention) and without (control) thegel pack. Results: Theintergroup analysis showed that the difference between the experimental,control and placebo groups in terms of their mean VAS scores obtained beforethe procedure and after the procedure was not statistically significant. But inthe experimental group; in terms of their mean VAS scores obtained before theprocedure and after the procedure was determined statistically significant.Conclusions: Theresults of this study showed that cold therapy is an effective method for managementof sternal incision pain associated with coughing and deep breathing in open heartsurgery patients.Key words: Postoperative Pain,Breathing Exercises, Cardiac Surgery, Post-SurgicalNursing.
Data from [6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A<sub>4</sub> Hydrolase

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

<div>Abstract<p>[6]-Gingerol, a natural component of ginger, exhibits anti-inflammatory and antitumorigenic activities. Despite its potential efficacy in cancer, the mechanism by which [6]-gingerol exerts its chemopreventive effects remains elusive. The leukotriene A<sub>4</sub> hydrolase (LTA<sub>4</sub>H) protein is regarded as a relevant target for cancer therapy. Our <i>in silico</i> prediction using a reverse-docking approach revealed that LTA<sub>4</sub>H might be a potential target of [6]-gingerol. We supported our prediction by showing that [6]-gingerol suppresses anchorage-independent cancer cell growth by inhibiting LTA<sub>4</sub>H activity in HCT116 colorectal cancer cells. We showed that [6]-gingerol effectively suppressed tumor growth <i>in vivo</i> in nude mice, an effect that was mediated by inhibition of LTA<sub>4</sub>H activity. Collectively, these findings indicate a crucial role of LTA<sub>4</sub>H in cancer and also support the anticancer efficacy of [6]-gingerol targeting of LTA<sub>4</sub>H for the prevention of colorectal cancer. [Cancer Res 2009;69(13):5584–91]</p></div>
Use of Contact Force Mapping to identify low Voltage Bridging to guide radiofrequency ablation of slow pathway: A single Center Study

Field: Medicine (Health Sciences)

Introduction: Ablation of slow pathway (SP) for AV nodal reentry tachycardia (AVNRT), by visualization of low voltage bridges using non-contact force sensing (CFS) catheters and cryo-ablation has been described. This study aims to demonstrate the use of voltage mapping using CFS catheters in patients with AVNRT undergoing SP modification by Radiofrequency ablation (RFA). Methods Three-dimensional mapping was performed using CFS catheter in adult patients undergoing AVNRT ablation. Voltage values from intracardiac recordings were adjusted until a low voltage bridge was observed. Both electro-anatomical data and low voltage bridges were used to guide ablation. Distance from the earliest His signal to the site of SP (His-SP) and the area of the Koch’s triangle (KTArea) was measured. Results A total of 41 adult patients (63% female, 48±15 years) underwent RFA using CFS catheters. Median follow up was 12 months. There were no recurrences in any patients. When indexed to body surface area (BSA), both mean His-SP distance (p=0.038) and mean KTArea (p=0.019) was greater in patients with atypical AVNRT (n=5) than in patients with typical AVNRT (n=32). Conclusion RFA of AVNRT by visualization of low voltage bridges using CFS is effective. In patients with atypical AVNRT, SPs are particularly distant from the His region. Patients with atypical AVNRT have a larger Koch’s triangle than patients with typical AVNRT.
Effects of Core Exercise on Low Back Pain in the Elderly

Field: Health Professions (Health Sciences)

연구 목적: 본 연구는 노인 요통 감소에 코어 운동의 효과를 체계적으로 문헌고찰하고 메타분석을 실시하여 노인 요통 감소에 코어 운동프로그램 적용 근거를 제공하기 위해 시행되었다.연구 방법: 2023년 1월 25일까지 보고된 실험조사 설계와 비교집단이 있는 유사실험 조사설계를 검색하여 PRISMA 지침에 따라 문헌을 선정했다. Cochrane Review Manager(RevMan) 5.4.1프로그램을 이용해 효과크기를 분석하였다. 최종 문헌의 비뚤림 위험 평가는 무작위 연구는 RoB 2, 비무작위 연구는 ROBINS-I으로 했다.연구 내용: 요통이 있는 노인에게 특별한 장비나 도움 없이 적용된 코어 운동프로그램의 효과를 분석하기 위해 메타분석을 실시하였다.결론 및 제언: 연구결과 총 510편이 검색되었으며, 선택과 배제기준에 따라 5편을 분석하였다. 코어 운동프로그램을 실시한 실험군과 대조군의 VAS 평균차이는 -0.73이었으며, 연구결과 간의 이질성은 중간 정도로 나타나(I2=46%), 코어 운동프로그램은 요통감소에 효과적이었다. 본 연구를 통해 코어 운동프로그램이 노인의 요통 관리 중재로 활용할 수 있는 임상적 근거를 마련하였다.
In vivo and in vitro comparative studies of Origanum species

Field: Agricultural and Biological Sciences (Life Sciences)

Calli cultures were induced from leaf explants of the different species of Origanum. Influence of different types of nutrient media i.e., MS or LS or B5 on calli production as well as the effect of various growth regulators, i.e., 2,4-D, Kin, NAA and BAP at different concentrations on different morphological responses were studied. MS-medium showed to be the best type of nutrient medium on both calli production and/or calli differentiation from leaf explants of Origanum spp. Furthermore, the maximum value of calli production was recorded with O. vulgare L. as compared with the other Origanum species. On the other hand, GC and GC/MS analyses showed that the three oils in vivo varied quantitatively and qualitatively. Carvacrol was detected in the three species with variable concentration. Thymol was detected only in O. vulgare L. Carene-δ2 was found only in O. syriacum and O. vulgare. However, α-pinene was found in the three species under study without great variation. Different molecular markers i.e., SDS-PAGE protein profile and RAPD-based DNA fingerprints were carried out in the obtained calli cultures as compared with intact leaf plants and suggest different variation.
The influence of culture on destination image formation: a critical review

Field: Social Sciences (Social Sciences)

Numerous theoretical frameworks have been developed to clarify the gap between the factors influencing image formation and destination image. Researchers have included few more factors being investigated in the relationships with destination image, and one factor that has gained increasing interest among researchers is cultural factor. Thus, the purpose of this paper is to enrich the body of knowledge on destination image by determining the cultural dimension having potential influence on destination image formation. In understanding tourist destination image, several streams of research has been conducted throughout the world. The first stream concerns what constitute a destination image, which is closely related to studies about the formation process of a tourist destination image. The second stream of research focuses on the factors influencing destination image. Under the second stream of research, many studies came up with mixed conclusion. i.e. there are factors that were found to have positive as well as negative influences on a tourist destination image. At the same time, the range of possible factors influencing the destination image include personal factors and stimulus factors. This current study explains a few of the most influential and commonly used analytical framework in destination image studies. It then analyses the factors that have been found to have some influence, positive or negative on the destination image formation such as personal factors (motivation and demographic characteristics) and stimulus factors (previous experience and information sources). This paper discussed studies which examine the relationship between culture and destination image with the intention to highlight the need to include the many facets of cultural factors in destination image formation as well as in understanding tourists’ behaviour.
Rheological, microbiological, and in vitro digestive properties of Kefir produced with different Kefir grains and commercial starter cultures

Field: Agricultural and Biological Sciences (Life Sciences)

This research investigates the production of kefir using Turkish and Kazakh kefir grains and commercial starter cultures, followed by storage at 4 °C for 30 days. The study monitors the rheological properties and microbiological characteristics of kefir on the 1 st , 15 th , and 30 th days of storage, as well as during dynamic in vitro gastrointestinal digestion. Kefir samples were passed through a dynamic in vitro gastrointestinal model simulating the digestive processes of the mouth, stomach, and small intestine which was designed in laboratory conditions. Kefir from Turkish kefir grain exhibited the lowest average titratable acidity, apparent viscosity, and flow behavior index, while kefir from Kazakh kefir grain had the highest average pH. Over the storage period, pH and flow behavior index decreased, while titratable acidity, viscosity, and consistency coefficient increased. The kefir samples showed non-Newtonian pseudoplastic flow characteristics. The acetic acid bacteria and Leuconostoc counts of kefir samples produced with commercial starter cultures were higher than those produced with kefir grains, while yeast counts were higher in kefir samples produced with kefir grains. During storage and in vitro gastrointestinal digestion, the number of microorganisms in kefir samples decreased. Turkish kefir grain resulted in the lowest reduction (%) of microorganism counts during in vitro gastrointestinal digestion. These findings shed light on the rheological, microbiological, and in vitro digestive properties of kefir during storage, which may contribute to improving the quality and health benefits of kefir products. The present study revealed that the kefir produced with kefir grains had a lower decrease in the viability of microorganisms compared to the kefir produced with starter culture after passage through the gastrointestinal model, so kefir produced with kefir grains may be more preferred due to its possible health benefits.
Nonlinear State Feedback Synthesis by Global Input/Output Linearization

Field: Computer Science (Physical Sciences)

This paper studies the design of feedback controllers for trajectory tracking in single-input single-output nonlinear systems ⨰ = f(x) + g(x)u, y = h(x). A nonlinear transformation of the form v = κ(x) + λ(x)u that transforms this nonlinear input/output system into a linear system is first constructed. On the basis of this transformation, an approach for designing control laws for trajectory tracking is presented. The control law is robust in the sense that small changes in it do not produce large steady-state errors or loss of stability. The theory provides a unified framework for treating control problems arising in batch chemical processes; this is illustrated by an example.
Scenarious modeling and justification of perspective intensity of motion of transport flow

Field: Decision Sciences (Social Sciences)

The article discusses the problematic aspects of justifying a project. Such issues include the formation of a sound system of indicators for assessing the effectiveness of the project solution, which has a special impact on the level of investment attractiveness of the project as a whole. The problem of assessing the effectiveness of the project, of its social and budgetary attractiveness for the region has not only not lost its relevance, but has also been transformed into of the most important conditions for ensuring effective management of all spheres of the region. The article poses the classical task of making decisions on the results of assessing the social and budgetary efficiency of the project for the region in a matrix format with an evaluation utility function. The principal distinguishing feature of the results of the study are schemes of manipulation in the evaluation activity associated with the selection of groups of optimality criteria. The article presents the results of scenario-variant studies on the substantiation of the significance of modeling, specifies the features and limitations in applying the statistical apparatus in constructing long-term forecasts for the development of the region and studying the intensity traffic flow.
On the magnetic field and circumstellar environment of the young O7 star θ 1 Orionis C ⋆ ASTRONOMY AND ASTROPHYSICS

Field: Physics and Astronomy (Physical Sciences)

Abstract. We present new circular spectropolarimetric observations of the young O-type star θ 1 Orionis C obtained with the MuSiCoS échelle spectropolarimeter and the 2mTélescope Bernard Lyot, in an attempt to detect the surface magnetic field structure invoked to explain the periodic variability of θ 1 Ori C at X-ray, UV and optical wavelengths. We obtain null detections with 250 G 1σ error bars for the disc-averaged line-of-sight (i.e. longitudinal) component of the surface magnetic field vector, from which we conclude that the polar strength of the dipole field structure is lower than 1.6 to 2.0 kG (with a confidence level of 87%), depending on the exact orientation of the magnetic and rotation axes with respect to the line of sight. We report as well the unexpected discovery of strong, time variable continuum circular polarisation in the spectrum of θ 1 Ori C, as well as depolarisation structures associated with nebular emission lines, indicating that this continuum polarisation (the nature of which is as yet unclear) is produced within the immediate circumstellar environment.
Streptomyces from traditional medicine: sources of new innovations in antibiotic discovery

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Given the increased reporting of multi-resistant bacteria and the shortage of newly approved medicines, researchers have been looking towards extreme and unusual environments as a new source of antibiotics. Streptomyces currently provides many of the world’s clinical antibiotics, so it comes as no surprise that these bacteria have recently been isolated from traditional medicine. Given the wide array of traditional medicines, it is hoped that these discoveries can provide the much sought after core structure diversity that will be required of a new generation of antibiotics. This review discusses the contribution of Streptomyces to antibiotics and the potential of newly discovered species in traditional medicine. We also explore how knowledge of traditional medicines can aid current initiatives in sourcing new and chemically diverse antibiotics.
Developing Career Skills of Professional Students Through Student Mentees - Alumni Mentoring Program

Field: Business, Management and Accounting (Social Sciences)

The present research explores to develop career skills of professional students through student mentees-alumni mentoring relationship program. In the study, 15 student mentees of engineering, 10 student mentees of management institutions and 5 of alumni mentors participated. A questionnaire was prepared with open and closed questions separately for the students on their feedback and alumni on their facilitations. Researchers conducted series of two semi-structured interviews and the results indicated that the students enhanced career skills and they acquired guidance and support from the alumni mentors and had the industry exposure. The mentors had satisfaction in guiding the students and this program helped them to refresh their technical and soft skills and in turn they demonstrate to their students. The findings and suggestions to be incorporated into the professional education institutions.
The discovery BPD (D-BPD) program: study protocol of a prospective translational multicenter collaborative study to investigate determinants of chronic lung disease in very low birth weight infants

Field: Medicine (Health Sciences)

Premature birth is a growing and serious public health problem affecting more than one of every ten infants worldwide. Bronchopulmonary dysplasia (BPD) is the most common neonatal morbidity associated with prematurity and infants with BPD suffer from increased incidence of respiratory infections, asthma, other forms of chronic lung illness, and death (Day and Ryan, Pediatr Res 81: 210-213, 2017; Isayama et la., JAMA Pediatr 171:271-279, 2017). BPD is now understood as a longitudinal disease process influenced by the intrauterine environment during gestation and modulated by gene-environment interactions throughout the neonatal and early childhood periods. Despite of this concept, there remains a paucity of multidisciplinary team-based approaches dedicated to the comprehensive study of this complex disease.The Discovery BPD (D-BPD) Program involves a cohort of infants < 1,250 g at birth prospectively followed until 6 years of age. The program integrates analysis of detailed clinical data by machine learning, genetic susceptibility and molecular translation studies.The current gap in understanding BPD as a complex multi-trait spectrum of different disease endotypes will be addressed by a bedside-to-bench and bench-to-bedside approach in the D-BPD program. The D-BPD will provide enhanced understanding of mechanisms, evolution and consequences of lung diseases in preterm infants. The D-BPD program represents a unique opportunity to combine the expertise of biologists, neonatologists, pulmonologists, geneticists and biostatisticians to examine the disease process from multiple perspectives with a singular goal of improving outcomes of premature infants.Does not apply for this study.
Evidence-Based Medicine Course for Pre-Clinical Medical Students and Evaluation of Their Self-Efficacy Perceptions

Field: Health Professions (Health Sciences)

Objective This study aims to share the results of the two-year implementation phase of the Evidence-Based Medicine (EBM) course, which was restructured and updated at Manisa Celal Bayar University Faculty of Medicine (MCBUFoM). Materials and Method All (N = 514) students enrolled in Year-1 at MCBUFoM in the academic years of 2018-2019 and 2019-2020 were included in this cross-sectional study. Course goal, competencies and learning objectives were determined and sessions were developed accordingly. This restructured 12-hour course was given in six sessions, four of which were theoretical and two were practical. Lectures, practical exercises using mobile devices in small groups and case-based problem-solving activities were used as instruction methods. Students’ self-efficacy perceptions and their feedback regarding the EBM course were collected via two separate online questionnaire forms containing structured and semi-structured items. The responses of the students who attended the EBM course sessions were analyzed and reported. ResultsA total of 195 Year-1 students (37.7%) responded to the survey questionnaires. One hundred seventy-two of these students (88.2%) reported that they attended EBM course sessions. Based on their participation, 68 (39.5%) students have not attended any practical sessions, and 104 (60.5%) students have attended at least one practical session. Ninety-one (65.0%) of the students stated that the time allocated to the course was sufficient. It was revealed that the mean total score of students' self-efficacy perceptions regarding the learning objectives of the EBM course was 3.41 ± 0.85, and the highest mean value was found in application dimension (3.49 ± 1.06). Students' self-efficacy perceptions were found to be significantly higher for the students who attended the practical sessions. Students’ level of satisfaction regarding the course was high for all evaluation domains. “The scope of the course” was most frequently (n = 86, 56.2%) reported response as the “most beneficial aspect of the course” by the students. ConclusionsThe findings obtained in this study were found to be compatible with the data reported in the literature. Starting the EBM training early, and continuing them throughout the medical education will increase the permanence of the knowledge acquired. Utilizing case-based clinical problems and mobile devices will have a significant positive impact on students' perception of self-efficacy concerning EBM.