jimnoneill/paper-to-field-training huggingface dataset:
Analysis of Users Post Adoption Satisfaction on Performance of Self Service Technologies: The Case of National Institute of Transport

Field: Business, Management and Accounting (Social Sciences)

Self service technologies are service technologies that assist customers to access, produce and deliver services with little or no help from service providers. The main objective of this is paper was to understand the satisfaction level of customers and user performance rating of SST by identifying motives behind customers adopting using Self service technologies.. Using pre-defined predictors that were designed with the help of various reviews of literature and were subjected to respondents in the form of questionnaires. The respondents were randomly selected and questionnaires were sent to 100 respondents, forty seven respondents returned their questionnaire filled. The result for Spearman’s Rank Correlation was used to test correlation between the SST performance determinants and the level of satisfaction which indicated there was positive correlation between the two. In case of the regression analysis which was testing the casual effect relationship between the determinants of service performance and customers satisfaction on Self Service performance the results showed the level of significance of t>.05 between them.
[Primary cancer of the vermiform appendix--case report and literature review].

Field: Medicine (Health Sciences)

The case history of an eighty one year old white male with progressive cachexia and massive ascites is given. Autopsy revealed the rare finding of a primary adenocarcinoma of the appendix with multiple metastases as the cause of the rapidly deteriorating clinical condition. The incidence, clinical findings and therapeutic options in carcinoma of the appendix are discusses based on a review of the literature.
Solution Structure of Mouse Hepatitis Virus (MHV) nsp3a and Determinants of the Interaction with MHV Nucleocapsid (N) Protein

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ABSTRACT Coronaviruses (CoVs) are positive-sense, single-stranded, enveloped RNA viruses that infect a variety of vertebrate hosts. The CoV nucleocapsid (N) protein contains two structurally independent RNA binding domains, designated the N-terminal domain (NTD) and the dimeric C-terminal domain (CTD), joined by a charged linker region rich in serine and arginine residues (SR-rich linker). An important goal in unraveling N function is to molecularly characterize N-protein interactions. Recent genetic evidence suggests that N interacts with nsp3a, a component of the viral replicase. Here we present the solution nuclear magnetic resonance (NMR) structure of mouse hepatitis virus (MHV) nsp3a and show, using isothermal titration calorimetry, that MHV N219, an N construct that extends into the SR-rich linker (residues 60 to 219), binds cognate nsp3a with high affinity (equilibrium association constant [ K a ], [1.4 ± 0.3] × 10 6 M −1 ). In contrast, neither N197, an N construct containing only the folded NTD (residues 60 to 197), nor the CTD dimer (residues 260 to 380) binds nsp3a with detectable affinity. This indicates that the key nsp3a binding determinants localize to the SR-rich linker, a finding consistent with those of reverse genetics studies. NMR chemical shift perturbation analysis reveals that the N-terminal region of an MHV N SR-rich linker peptide (residues 198 to 230) binds to the acidic face of MHV nsp3a containing the acidic α2 helix with an affinity (expressed as K a ) of 8.1 × 10 3 M −1 . These studies reveal that the SR-rich linker of MHV N is necessary but not sufficient to maintain this high-affinity binding to N.
Incorporating Customer Reviews in Size and Fit Recommendation systems for Fashion E-Commerce

Field: Computer Science (Physical Sciences)

With the huge growth in e-commerce domain, product recommendations have become an increasing field of interest amongst e-commerce companies. One of the more difficult tasks in product recommendations is size and fit predictions. There are a lot of size related returns and refunds in e-fashion domain which causes inconvenience to the customers as well as costs the company. Thus having a good size and fit recommendation system, which can predict the correct sizes for the customers will not only reduce size related returns and refunds but also improve customer experience. Early works in this field used traditional machine learning approaches to estimate customer and product sizes from purchase history. These methods suffered from cold start problem due to huge sparsity in the customer-product data. More recently, people have used deep learning to address this problem by embedding customer and product features. But none of them incorporates valuable customer feedback present on product pages along with the customer and product features. We propose a novel approach which can use information from customer reviews along with customer and product features for size and fit predictions. We demonstrate the effectiveness of our approach compared to using just product and customer features on 4 datasets. Our method shows an improvement of 1.37% - 4.31% in F1 (macro) score over the baseline across the 4 different datasets.
Growth of ɣ-Proteobacteria in Low Salt Cucumber Fermentation Is Prevented by Lactobacilli and the Cover Brine Ingredients

Field: Agricultural and Biological Sciences (Life Sciences)

While the abundance of specific ɣ-proteobacteria species varies among vegetable type, several harbor Enterobacteriaceae and Pseudomonadaceae that benefit the plant system. It is documented that such bacterial populations decrease in density early in vegetable fermentations.
Sortilin is associated with progranulin deficiency and autism‐like behaviors in valproic acid‐induced autism rats

Field: Neuroscience (Life Sciences)

Abstract Introduction Neuroinflammation and microglial activation‐related dendritic injury contribute to the pathogenesis of Autism Spectrum Disorder (ASD). Previous studies show that Progranulin (PGRN) is a growth factor associated with inflammation and synaptic development, but the role of PGRN in autism and the mechanisms underlying changes in PGRN expression remain unclear. Aims To investigate the impact of PGRN in autism, we stereotactically injected recombinant PGRN into the hippocampus of ASD model rats. Additionally, we explored the possibility that sortilin may be the factor behind the alterations in PGRN by utilizing SORT1 knockdown. Ultimately, we aimed to identify potential targets for the treatment of autism. Results PGRN could alleviate inflammatory responses, protect neuronal dendritic spines, and ameliorate autism‐like behaviors. Meanwhile, elevated expression of sortilin and decreased levels of PGRN were observed in both ASD patients and rats. Enhanced sortilin levels facilitated PGRN internalization into lysosomes. Notably, suppressing SORT1 expression amplified PGRN levels, lessened microglial activation, and mitigated inflammation, thereby alleviating autism‐like behaviors. Conclusion Collectively, our findings highlight elevated sortilin levels in ASD rat brains, exacerbating dendrite impairment by affecting PGRN expression. PGRN supplementation and SORT1 knockdown hold potential as therapeutic strategies for ASD.
PARRY ROMBERG’S SYNDROME: A CASE REPORT

Field: Medicine (Health Sciences)

We are reporting 18 year old female patient presented with facial asymmetry of right side of face with thinning of skin on right side of face.Patient also had multiple hyperpigmentation patches on right side of trunk and neck with right sided tongue atrophy.Radiological findings showed minimal right sided frontal lobe atrophy of brain.All these findings were suggestive of parry Romberg's syndrome.We hereby are presenting a case of Parry-Romberg syndrome with classical features along with radiological and histopathological findings.
Conformational studies of trinucleoside bisphosphates 2. Potential energy calculations

Field: Chemistry (Physical Sciences)

Semi‐empirical potential energy calculations were carried out for the conformations of ApApA, a trinucleoside bisphosphate (trimer), as proposed in the preceding paper in this journal. Energy minimals were obtained for these conformers, i.e. conformers I‐I, I‐II, III‐I′ and I′‐I′ (the first Roman numeral represents the conformation of the ApAp‐ moiety and the second one the ‐pApA moiety of ApApA), of the nearest‐neighbor interactions, and conformers B1, B2 and B3 of bulged structures. The results show that the detailed conformations of the component dinuclotide (dimer) moieties in I‐I, I‐II, III‐I′ and I′‐I′ are close (± 10°) to the corresponding stable conformations of dinucleotides in solution proposed by Lee and coworkers. The bulged conformations B1, B2 and B3 have open forms for each dinucleotide moiety. Their preferred local conformations are anti , γ + , β + , ɛ + (except for Apɛin B3, ɛ − ), and 3′ endo (except for Ap‐ in B3, 2′ endo ) for the glycosidic bond, C4′‐C5′, C5′‐O5′, C3′‐O3′ and the ribose moiety, respectively. The conformation of the phosphodiester linkage in ‐pApA moiety is ζ t 2 , α t 3 for all the three bulged conformers, while that in ApAp‐is ζ − 1 , α t 2 for B1, ζ + 1 α − 2 for B2, and ζ + 1 , α + 2 for B3. The calculated composite chemical shifts of the base protons from ring‐current effects agree with the corresponding observed trimerization shifts. Conformers I‐I and I′‐I′ are helix‐like structures and correspond to the right‐handed and the ‘vertical‐stacked’ helices, respectively. The structure of I‐II is similar to that observed in the ApApA single crystals. The bulged conformations may serve as models for frameshift mutations.
Light Element Production in the Circumstellar Matter of Type Ic Supernovae at Low Metallicity

Field: Physics and Astronomy (Physical Sciences)

We investigate energetic Type Ic supernovae as production sites for 6Li and Be in the early stages of the Milky Way. Recent observations have revealed that some very metal-poor stars with [Fe/H]< −2.5 possess unexpectedly high abundances of 6Li. Some also exhibit enhanced abundances of Be as well as N. From a theoretical point of view, recent studies of the evolution of metal-poor massive stars show that rotation-induced mixing can enrich the outer H and He layers
Evaluation of Oxidative Stress and Cellular Immunity in Grades III-IV Knee Osteoarthritis.

Field: Medicine (Health Sciences)

According to the findings of the current study; It is observed that the oxidant balance of individuals with osteoarthritis is disrupted in favor of free radicals, and as a result, cellular immunity decreases due to inflammation and the disease process. It is observed that these parameters change in direct proportion to the staging of the disease, especially in patients with stage III-IV knee osteoarthritis.
Information literacy: A Proposed Conceptual Framework for Agribusiness Education Reform

Field: Arts and Humanities (Social Sciences)

The global information intensive economy has brought many changes and challenges to all nations. In this new economy the availability of information is growing at an exponential rate and the technologies which are used to store and access this information continue to change rapidly. In small developing nation states such as those in the Caribbean, the combination of these two factors constitutes a serious threat to the region’s ability to compete effectively in the global marketplace simply because the region does not generally have a workforce which is skilled in the efficient use of information. Knowledge of, and the ability to use computer technology is not an adequate response to this challenge posed by the information society. What is required is a cadre of information consumers who have the ability to know when and how to effectively use the new technologies as well as when and how to use the resources to which these new technologies provide access. And, in this context one of the goals of institutions of higher education in the region must be to graduate these information consumers. To achieve this requires curriculum reform that is supported by an educational philosophy that is informed by the recognition of the critical role of information literacy skills for the knowledge economy. To support the authors’ contention that the teaching of these skills is critical for agribusiness development, the paper will present the results of a survey of the members of the Faculty of Agriculture at The University of the West Indies. The survey seeks to ascertain faculty perceptions of the importance of information literacy competencies for graduates in the faculty as well as their perception of the information research skills of the students they teach. Through the examination of these two variables the authors will propose a conceptual framework to transform the curriculum into one that will produce graduates who are information literate and functional as lifelong learners. In proposing this framework the authors will also establish the significant role information professionals have to play as partners working with academics and administrators to reform the curricula of agricultural education in the region.
Recombinant D-amino Acid Oxidase with Improved Properties

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract D-amino acid oxidase from Trigonopsis variabilis (TvDAAO) was overproduced in Escherichia coli cells, and properties of the recombinant enzyme were studied. Single point mutants of the enzyme with 2.4-fold higher thermal stability or changed spectra of substrate specificity compared with wild-type enzyme were prepared. It was shown that mutant TvDAAO has higher catalytic efficiency in cephalosporin C oxidation in comparison with wild-type enzyme. One mutant of recombinant TvDAAO was crystallized and its structure was solved with resolution 2.8 A.
Antioxidant and Free Radical Scavenging Activity of Trigonella foenum-graecum L, Murraya koenigii , Coriandrum sativum and Centella asiatica

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Antioxidants are naturally occurring substances that combat oxidative damage in biological entities. An antioxidant achieves this by slowing or preventing the oxidation process that can damage cells in the body. It does this by getting oxidized itself in place of the cells. The aim of the present study was to evaluate the in vitro antioxidant and free radical scavenging activities of aqueous and 95% methanol leaf extracts of four herbs viz. Trigonella foenum-graecum L, Murraya koenigii, Coriandrum sativum and Centella asiatica which have frequent use in Indian cuisine. Both aqueous and 95% methanol leaf extracts have shown significant amount reducing power. Both aqueous and 95% methanol leaf extracts of Coriandrum sativum had significant DPPH radical scavenging activity with IC50 value of 0.21± 0.3 mg/L and 0.176 ± 0.008 mg/L respectively. The aqueous leaf extract of Trigonella foenum-graecum L showed low scavenging activity. Among all the leaf extracts, the aqueous leaf extract of Centella asiatica has exhibited significantly high NO radical scavenging activity (80%) with IC50 value of 0.11 ± 0.17 mg/L. The aqueous leaf extracts of the samples have showed significantly high superoxide radical scavenging activity. The activity was maximum for the aqueous leaf extract of Centella asiatica, IC50 value is 4.36 ± 0.41 mg/L. anti lipid peroxide activities were very high ( 90 %) for aqueous leaf extracts of Coriandrum sativum (IC50 = 0.064 ± 0.85 mg/L) and Centella asiatica (IC50 = 0.066 ± 0.9mg/L) at a concentration of 0.16 mg/L. The aqueous leaf extracts of the samples were found to contain large amounts of flavonoids and phenolic compounds and exhibited high antioxidant and free radical scavenging activities. These in vitro assays indicate that these plant extracts are significant source of natural antioxidants which might be helpful in preventing the progress of various oxidative stresses.
[Surgery of dysphagic diseases. Personal experience (349 surgical interventions)].

Field: Medicine (Health Sciences)

The authors report their surgical experience relating to dysphagic diseases of the esophagus (349 cases). In the light of these results, they describe the different surgical techniques used in the various pathologies: 1) Esophageal diverticula: The value of a careful evaluation of subdiverticular spasm is emphasised using preoperative manometry in cervical and epiphrenic diverticula, leading to subdiverticular myotomy when present. 2) esophageal achalasia and intermediate motor disorder: A clear difference must be drawn between these two diseases owing to the different motor behaviour of the esophagus. Dilatation of the LES is only useful in intermediate motor disorder and should be avoided in esophageal achalasia where a gastroesophageal reflux is produced if dilatation fails. Intraoperative manometry is very useful during the extramucosa myotomy phases as an indication of the complete removal of the sphincteric barrier, thus avoiding the risk of persisting disease. 3) Non-neoplastic stenosis. In primary stenosis (caused by caustic agents, primary GER or associated with JE) a conservative approach is advisable, whereas in iatrogenic stenosis (mainly linked to dilatation or cardiac surgery), owing to the anatomic complexity of the esophagogastric junction, a more radical approach is often required in the form of esophagogastric resection or even sub-total esophagectomy. 4) Neoplastic stenosis: Leiomyomas, although unusual, represent a clear indication for thoracoscopic access, provided that the dimensions allow it. Esophageal cancers represent a major surgical problem. A radical approach is represented by TE and the subsequent use of the stomach, or more rarely, the colon to reconstruct the alimentary tract. In spite of the very low resectability rate owing to locoregional spreading, until recently palliative surgery was essential to allow patients to eat. The introduction of autoexpanding prostheses, positioned using endoscopic methods, has provided a better solution to this problem.
FRO 2014: using targeted next‐generation sequencing to identify genes underlying keratoconus

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract This project is part of a larger PhD project which aims to unravel the molecular pathology of keratoconus (KC). During the first part of my PhD, the focus was placed on the identification of genes that underlie KC. Using whole exome sequencing of large KC families, 8 genes were identified that might be implicated in the disease pathogenicity. In this project, we will further establish the (causative) role of these genes in KC. We will develop a gene panel that will be screened in a population of approximately 750 KC patients and 750 ethnically‐matched healthy individuals using next‐generation sequencing (NGS). The comparison between both groups will allow identification of genes that are frequently mutated in KC patients. As these genes most likely play a role in the pathogenesis, identification of causative genes and their functional role in biochemical pathways will allow us to unravel the biochemical background of the disease, and form the basis for potential new forms of therapy.
Cellular and biochemical antileukemic mechanisms of the meroterpenoid Oncocalyxone A

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Oncocalyxone A, a 1,4-benzoquinone derived from Cordia oncocalyx, exhibits anti-inflammatory, antimicrobial and antidiabetic properties. The aim of this study was to (1) examine the cytotoxic actions of oncocalyxone A on human normal and tumor cell lines and (2) determine mechanistic actions underlying effects upon leukemia cells using cellular and molecular techniques. Antiproliferative studies on cancer cell lines, peripheral blood mononuclear cells, and human erythrocytes were performed using colorimetric assays. To understand cytotoxicity, assessments were performed with HL-60 leukemia cells (8, 16.5, or 33 µM) after 24 hr incubation using light and fluorescence microscopy, trypan blue, flow cytometry, Comet assay, western blot of caspases and poly-ADP-ribose polymerase (PARP), and effects on topoisomerase I and II. Oncocalyxone A exhibited cytotoxic action upon HL-60 cells and dividing leukocytes, but minimal hemolytic action on erythrocytes. Mechanistic investigations demonstrated reduction of cell viability, loss of membrane integrity, cell shrinking, chromatin condensation, blebbings, externalization of phosphatidylserine, caspase activation, PARP cleavage, mitochondrial depolarization, and DNA damage. Pre-treatment with N-acetylcysteine 4 mM significantly reduced DNA damage and prevented membrane integrity loss. Oncocalyxone A displayed free radical dependent antileukemic activity via apoptotic pathways and induced DNA damage in HL-60 cells. Oncocalyxone A possesses structural chemical simplicity enabling it to be a cost-effective alternative. These properties justify further improvements to enhance activity and selectivity and the development of pharmaceutical formulations. Abbreviations Acridine orange, AO; ANOVA, analysis of variance; BSA, bovine serum albumin; DI, Damage Index; DMSO, dimethylsulfoxide; EC50, effective concentration 50%; EDTA, ethylenediamine tetraacetic acid; EB, ethidium bromide; HCT-116, colon carcinoma line; HL-60, promyelocytic leukemia line; IC50, inhibitory concentration 50%; MTT, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide; OVCAR-8, ovarian carcinoma line; NAC, N-acetylcysteine, PBMC, peripheral blood mononuclear cells; PBS, phosphate-buffered saline; PI, propidium iodide; PARP, poly-ADP-ribose polymerase; RPMI-1640, Roswell Park Memorial Institute medium; SF-295, glioblastoma line; ROS, reactive oxygen species; 7-AAD, 7-amino-actinomycin D; H2-DCF-DA, 7'-dichlorodihydrofluorescein diacetate.
Data from The HDAC2-SP1 axis orchestrates pro-tumor macrophage polarization

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<div>Abstract<p>Tumor-associated macrophages (TAMs), including anti-tumor M1-like TAMs and pro-tumor M2-like TAMs, are transcriptionally dynamic innate immune cells with diverse roles in lung cancer development. Epigenetic regulators are key in controlling macrophage fate in the heterogeneous tumor microenvironment. Here, we demonstrate that the spatial proximity of HDAC2–overexpressing M2-like TAMs to tumor cells significantly correlates with poor overall survival of lung cancer patients. Suppression of HDAC2 in TAMs altered macrophage phenotype, migration, and signaling pathways related to interleukins, chemokines, cytokines, and T cell activation. In co-culture systems of TAMs and cancer cells, suppressing HDAC2 in TAMs resulted in reduced proliferation and migration, increased apoptosis of cancer cell lines and primary lung cancer cells, and attenuated endothelial cell tube formation. HDAC2 regulated the M2-like TAM phenotype via acetylation of histone H3 and transcription factor SP1. Myeloid cell–specific deletion of Hdac2 and pharmacological inhibition of class I HDACs in four different murine lung cancer models induced the switch from M2-like to M1-like TAMs, altered infiltration of CD4+ and CD8+ T cells, and reduced tumor growth and angiogenesis. TAM-specific HDAC2 expression may provide a biomarker for lung cancer stratification and a target for developing improved therapeutic approaches.</p></div>