jimnoneill/paper-to-field-training huggingface dataset:
A GLOBAL PENTECOSTAL THEOLOGY? AMOS YONG'S THE SPIRIT POURED OUT ON ALL FLESH*

Field: Arts and Humanities (Social Sciences)

Revenue increased by 23.8% and EBITDA by 9.1%, with strong development in Q4 • V&R exceeded expectations, integration on track • Net profit grew by 4.8% despite V&R integration costs • eBook sales grew organically by 20% and including V&R by 33.5% • Proposed dividend of EUR 0.90 per (certificate) of ordinary share Business Case Distribution Reporting & Finance systems Workflows ERP Integration & Relaunch
Integrative literature review: a review of literature related to geographical information systems, healthcare access, and health outcomes.

Field: Health Professions (Health Sciences)

Differences in access to healthcare services and the resulting adverse health outcomes are major public health priorities. The Institute of Medicine and the Department of Health and Human Services have identified the need for strategies to improve access to healthcare services and to support the improvement of health outcomes. The literature documents health disparities associated with healthcare access and health outcomes from a geographic perspective. Place of residence, location of healthcare services, and geography in general are important factors in the analysis of health. Geographical information systems (GISs) are an emerging technology in the analysis of health from a geographical or location context. As a type of information technology, GISs are potentially powerful assessment tools for the investigation of healthcare access, health outcomes, and the possible resulting health disparities. Their ability to integrate health data with mapping functions allows for visualization, exploration, and modeling of health patterns. Application of GIS technology using health data can help in describing and explaining disparities in healthcare access and health outcomes. The studies reviewed demonstrated the use of GISs to investigate various aspects of healthcare access and health outcomes, including environmental variables of Lyme disease, sociodemographic variables and teen pregnancy, geographical disparities in breast cancer mortality by racial groups, PCP and AIDS prevalence, and factors of a leptospirosis disease outbreak. The literature reviewed shows effective integration and analysis of health data using GIS technology.
Use of trichlorethylene inhalations during physiotherapy.

Field: Medicine (Health Sciences)

Background

There are many possible predisposing factors for Achilles tendon disorders suggested in the literature but their pathogenetic relevance is not proven in most cases. The asymmetric mechanical load distribution within the Achilles tendon during locomotion is frequently addressed as a major risk factor for Achilles tendon disorders. The spatial orientation of the subtalar joint axis (STA) may influence the Achilles tendon loading possibly leading to overload injuries.

Hypothesis

There is a significant difference between the orientation of the STA in subjects with and without Achilles tendon pathologies.

Materials and methods

614 subtalar joint axes determined in 307 long-distance runners with and without Achilles tendon disorders were included. Achilles tendon disorders were defined as any Achilles tendon–related pain during or following running, existing for more than 2 weeks in the past. Motion analysis of the foot was performed using an ultrasonic pulse-echo-based measurement system. The orientation of the STA was expressed by two angles.

Results

The mean inclination angle was 42±16° and the mean deviation angle was 11±23°. There was a significant difference (p=0.002) between the mean deviation angle measured in subjects with Achilles tendon pathologies (18±23°) and those without (10±23°).

Conclusions

The results demonstrate a wide interindividual variability of the spatial orientation of the STA. In addition, the mean deviation angle in people with Achilles tendon pathologies is significantly more oblique than in people without. This finding indicates that the spatial orientation of the STA is related to the incidence of overuse injuries of the Achilles tendon in the investigated sample.
Prostate Cancer Disparities in an Incarcerated Community

Field: Health Professions (Health Sciences)

Abstract : The Prostate Cancer Health Disparities Training Award is intended to provide early career researchers the opportunity to acquire training that will promote careers focused on improving prostate cancer outcomes, and decreasing prostate cancer disparities. Award W81XWH-11-1- 0729, PC102033, focuses on providing training to Principal Investigator (PI) Meghan E. Borysova, Ph.D., through a detailed training program coupled with conducting research on prostate cancer disparities in a department of corrections. The PI is a postdoctoral fellow in the College of Public Health (COPH) at the University of South Florida in Tampa, Florida; institutions which view Health Disparities as a matter of public health concern and work tirelessly to improve health of all individuals and communities. The training component of this award includes direct mentorship, attendance at conferences, seminars, lectures, presentations of data through meetings and manuscripts, grant writing experience, professional networking and coursework. The research component of this award includes conducting a 10-year retrospective analysis of incidences and mortality of prostate cancer among incarcerated communities, and studying the cross-racial and ethnic prevalence of conjectural behaviors and biological markers associated with increased and decreased risks for prostate cancer within the incarcerated population.
LEGAL PROTECTION OF INVESTORS ON THE LAJNAH BISNIS SYARIAH (LBS) PLATFOREM

Field: Social Sciences (Social Sciences)

Sharia investment through digital platforms in Indonesia. One of the Sharia investment platforms in the form of sukuk offerings is Lajnah Bisnis Syariah (LBS). The problem is that investments carried out at LBS experience many obstacles that are detrimental to investors. This is exacerbated by the absence of legal protection for investors in investor agreements with LBS. This research examines further the legal protection and regulations for LBS investors when facing problems with sukuk offerings that affect results and harm investors. The research method used is normative empirical. This qualitative data analysis method describes policies relating to legal protection for investors against risks associated with issuers experiencing problems with Sukuk. The findings of this research are that investors have the opportunity to understand better companies issuing sukuk, so they can reach better profit-sharing agreements and manage the risks associated with managing the business. The availability of information aims to reduce problems that may arise in sukuk offerings by issuers and increase capital market efficiency. This research concludes that PT Tri Buana Cemerlang investors offering sukuk through the Lajnah Bisnis Syariah (LBS) platform are protected by preventive legal mechanisms with problem resolution through non-litigation channels
PATHOGENIC ROLE OF PARKINSON’S DISEASE-ASSOCIATED MIRO1 MUTATIONS IN THE MITOCHONDRIAL-ENDOPLASMIC RETICULUM INTERPLAY

Field: Neuroscience (Life Sciences)

Parkinson´s disease (PD) is a chronic neurodegenerative disorder, in which only 5-10% of the cases are caused by genetic mutations. One of the main pathological hallmarks of PD is the loss of midbrain dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of diseased brains. These DA neurons require large amounts of energy for the maintenance of their pace-making activity and their complex dendritic and axonal arborizations, features that force them to rely on a fully functional mitochondrial network. In this regard, mitochondrial dyshomeostasis is a central factor in PD pathophysiology. Mitochondria are considered the powerhouse of the cells, and they are extremely dynamic organelles that are distributed throughout the entire neuronal body to meet the cellular energy demands. The maintenance of mitochondrial function requires their interaction with other cellular organelles, in particular, the endoplasmic reticulum (ER). Overwhelming evidence indicates that the mitochondrial-ER interface is a potential target of growing importance for the investigation of PD. Several PD-related proteins were found to be involved in the structural maintenance and signaling regulation of mitochondrial-ER contact sites (MERCs). In recent years, myriad studies have identified the mitochondrial GTPase Miro1 as a crucial player in PD pathology. Miro1 protein is not only an adaptor for mitochondrial transport, but also acts as a cytosolic calcium sensor and as an ubiquitination target for the mitochondrial quality control machinery. Moreover, Miro1 can localize to MERCs, where it functions as a regulator of the calcium exchange between both organelles. To date, no genetic link between Miro1 and PD has been identified, and the influence of Miro1 in the regulation of MERCs within the context of neurodegeneration is still underestimated. This current study explored the damaging effect of novel PD-associated heterozygous mutations in RHOT1, the gene encoding Miro1 protein, in a diseased genetic background. We first obtained skin fibroblasts from the affected PD patients harboring Miro1 mutations, which we further differentiated into iPSC-derived neurons. The characterization of the mutations in both patient-derived cellular models unveiled important impairments in mitochondrial calcium homeostasis and sensitivity to calcium stress, associated with alterations in the abundance and functionality of the MERCs. Consequently, downstream pathways to these mechanisms were affected, such as autophagy flux and mitochondrial clearance. From our results, we can conclude that PD-associated mutant Miro1 leads to crucial alterations in MERCs, consequently affecting downstream mechanisms such as calcium homeostasis and mitophagy. These dysregulations might lead to an increased sensitivity to stress and finally cell death. Our findings strongly support the key role of MERCs in the progress of neurodegeneration and establish RHOT1 as a rare genetic risk factor in PD.
Expression profiles of heat shock protein 70 and high‐mobility groups box‐1 protein in gnotobiotic brine shrimp challenged with different virulence levels of isogenic Vibrio harveyi strains

Field: Agricultural and Biological Sciences (Life Sciences)

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The original contributions presented in the study are included in the article, further inquiries can be directed to the corresponding author.
Determinants of E-government Adoption: A Systematic Literature Review

Field: Social Sciences (Social Sciences)

The adoption of E-government has significant benefits for both citizens and governments. The objectives of this study were to (1) find out the common areas investigated in the empirical research landscape on E-government adoption from 2015 to 2020, as well as (2) the areas that need more focus for research. The systematic literature review methodology was used in this study. Fifty-five empirical articles published during the 2015-2020 period in journals were extracted from the Scopus database. The review’s article selection and findings are published following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. According to the findings, the perceived usefulness, perceived easiness, trust, and perceived risk of Technology Acceptance Models (TAM) and performance expectancy, effort expectancy, social influence, and facilitating conditions of the Unified Theory of Acceptance and Use of Technology (UTAUT) model have all been extensively studied. They are the determinants for E-government adoption. Additionally, citizen awareness, cost of services, citizen satisfaction, digital inequality, and individual motivators are determinants of E-government adoption. The research implications and future research agendas are also provided.
Ensuring economic security of the municipalities: best practices

Field: Social Sciences (Social Sciences)

The subject of this research is the best practices of ensuring economic security of municipalities of the Russian Federation. The object of this research is the process of ensuring economic security of the municipalities. The author meticulously examines the state of economic security of municipalities of the Russian Federation. Special attention is given to monotowns, whose economy is dominated by a single industry or company. It is underlined that the critical state of backbone enterprises usually leads to deterioration of economic security and emergence of crisis phenomena in socioeconomic sphere of the municipalities. The article presents practical experience of restoring the role of the Russian textile factory during bankruptcy proceedings. Rendering support to the backbone enterprises in overcoming crisis situations, the municipalities simultaneously address the issues of ensuring their economic security and socioeconomic development. The novelty of this research consists in the statement that restoration of the activity of backbone enterprises and ensuring economic security in the Russian municipalities is possible, even in the conditions of bankruptcy proceedings of the backbone enterprises. Ensuring the economic security of Russian municipalities is achieved by active support of the backbone enterprises by local communities; implementation of modern management methods in assessment of the state of economic objects, initiation of measures for overcoming crisis phenomena in the economy of municipalities; development of constructive principles as the foundation for supporting the backbone enterprises and ensuring economic security of the municipality. Positive experience acquired by the municipality &ldquo;Kirzhachsky District of Vladimir Region&rdquo; in ensuring its economic security by supporting and restoring the role of the backbone enterprise of the district remains relevant, and can be implemented by other Russian municipalities in their management practice.
Assessing Laboratory Procedures for the Decontamination of Polar Snow or Ice Samples for the Analysis of Toxic Metals and Metalloids

Field: Environmental Science (Physical Sciences)

Most, if not all, Antarctic and Greenland snow and ice samples to be analyzed for toxic metals and metalloids such as Pb, Hg, Sb, Cd, Ag, Se, As, Cu and Zn become more or less contaminated by these elements on their outsides, mainly during field collection. We assess here the various procedures which have been developed to try to decontaminate the samples. They include both mechanical and rinsing techniques. It appears that it is essential, but very difficult, to establish clearly the efficiency of these procedures. This can however be done by determining the geometry of contamination of the analyzed samples and by evaluating procedural blanks carefully. Such careful evaluation has been achieved at present only for mechanical procedures and for a few metals.
Unlocking Opportunities for Migrant Workers in China: Analyzing the Impact of Health Insurance on Hukou Switching Intentions

Field: Social Sciences (Social Sciences)

The Chinese urban–rural binary health insurance structure has contributed to a significant urban–rural segmentation and regional fragmentation, which will affect labor mobilization and urbanization. The purpose of this research is to study whether and how urban–rural binary health insurance impacts the intentions of migrant workers to switch between rural and urban hukou. Pooled data were drawn from China Migrants Dynamic Survey, collected by the National Health Commission of China. The study applied the instrument variable model due to the existence of the endogeneity; and the IVprobit model to conduct the empirical analysis. Our findings are as follows: (1) the urban–rural binary health insurance affects migrant workers’ intentions to switch to urban hukou significantly. (2) The negative impact of originally rural health insurance on migrant workers’ intention of switching to urban hukou is relatively large for low-education-level migrant workers. (3) Compared with new generation of migrant workers, old migrant workers have higher health insurance dependency levels. Finally, our research suggested several policy implications, such as accelerating the establishment of a unified urban–rural health insurance system, increasing the urban health insurance participation rate of migrant workers in their working cities, and including migrant workers in the scope of equal access to urban public services, etc. All the policy suggestions are essential in order to accelerate the citizenization of migrant workers, improve the quality of urbanization, and promote the construction of a unified national labor market.
The Path Computation Element (PCE)

Field: Computer Science (Physical Sciences)

The Internet Engineering Task Force (IETF) has promoted the Path Computation Element (PCE) architecture to provide effective network resource utilization while guaranteeing advanced Internet applications with adequate quality of service (QoS). The PCE is a dedicated network entity devoted to path computation. This chapter presents the state-of-the-art of the PCE architecture for different networking scenarios including single-domain networks, optical networks, and multi-domain/layer networks. Relevant architectural and implementation aspects are analyzed and discussed, highlighting related benefits, limitations and open issues. Recent progresses and future directions are also addressed, including the PCE evolution to operate in the context of software defined networking.
Two conjectures on the primes which admit deconcatenation in two primes, involving multiples of 30

Field: Mathematics (Physical Sciences)

In this paper I state the following two conjectures: (I) If p is a prime which admits deconcatenation in two primes p1 and p2, both of the form 6*k – 1, then there exist an infinity of primes q obtained concatenating q1 with q2, where q1 = 30*n – p1, q2 = 30*n – p2 and n positive integer; (II) If p is a prime which admits deconcatenation in two primes p1 and p2, both of the form 6*k + 1, then there exist an infinity of primes q obtained concatenating q1 with q2, where q1 = 30*n + p1, q2 = 30*n + p2 and n positive integer.
RETRACTED ARTICLE: The abnormal expression of chromosomal region maintenance 1 (CRM1)-survivin axis in ovarian cancer and its related mechanisms regulating proliferation and apoptosis of ovarian cancer cells

Field: Medicine (Health Sciences)

Ovarian cancer (OC) is the main type of cancer that affects the female reproductive system and has a high morbidity and mortality rate. This study aimed to explore the regulatory effect of the chromosomal region maintenance 1 (CRM1)-survivin axis on the progression of OC. Ovarian cancer cells were transfected with pcDNA3.1-survivin and short hairpin RNA (sh)-CRM1. Cell proliferation was analyzed by cell counting kit-8 (CCK8), 5-ethynyl-2´-deoxyuridine (EdU) staining, and colony formation assays. Apoptosis was detected using flow cytometry. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were performed to analyze the expression of RNA and protein, respectively. qRT-PCR and prognostic correlation analyses revealed that CRM1 is highly expressed in OC cells and related to survival. The results of qRT-PCR, CCK8, colony formation test, EdU staining, flow cytometry, and Western blotting showed that CRM1 silencing inhibited the proliferation and colony formation of OVCAR 3 and SKOV3 cells and promoted cell apoptosis by promoting Caspase-3 activation. Survivin was positively regulated by CRM1 and promoted the development of OC. The results of the rescue experiment showed that overexpression of survivin reversed the inhibitory effect of CRM1 knockdown on the proliferation of ovarian cancer cells and its inhibitory effect on apoptosis. Our findings confirm the role of the CRM1-survivin signal transduction axis in OC by regulating the proliferation and apoptosis of OC cells, and may thus serve as a potential therapeutic target for OC.
TH-AB-202-10: Quantifying the Accuracy and Precision of Six Degree-Of-Freedom Motion Estimation for Use in Real-Time Tumor Motion Monitoring During Radiotherapy

Field: Medicine (Health Sciences)

Purpose: Kilovoltage intrafraction monitoring (KIM) scheme has been successfully used to simultaneously monitor 3D tumor motion during radiotherapy. Recently, an iterative closest point (ICP) algorithm was implemented in KIM to also measure rotations about three axes, enabling real-time tracking of tumor motion in six degrees-of-freedom (DoF). This study aims to evaluate the accuracy of the six DoF motion estimates of KIM by comparing it with the corresponding motion (i) measured by the Calypso; and (ii) derived from kV/MV triangulation. Methods: (i) Various motions (static and dynamic) were applied to a CIRS phantom with three embedded electromagnetic transponders (Calypso Medical) using a 5D motion platform (HexaMotion) and a rotating treatment couch while both KIM and Calypso were used to concurrently track the phantom motion in six DoF. (ii) KIM was also used to retrospectively estimate six DoF motion from continuous sets of kV projections of a prostate, implanted with three gold fiducial markers (2 patients with 80 fractions in total), acquired during the treatment. Corresponding motion was obtained from kV/MV triangulation using a closed form least squares method based on three markers’ positions. Only the frames where all three markers were present were used in the analysis. The mean differences between the corresponding motion estimates were calculated for each DoF. Results: Experimental results showed that the mean of absolute differences in six DoF phantom motion measured by Calypso and KIM were within 1.1° and 0.7 mm. kV/MV triangulation derived six DoF prostate tumor better agreed with KIM estimated motion with the mean (s.d.) difference of up to 0.2° (1.36°) and 0.2 (0.25) mm for rotation and translation, respectively. Conclusion: These results suggest that KIM can provide an accurate six DoF intrafraction tumor during radiotherapy.
Redirecting meiotic DNA break hotspot determinant proteins alters localized spatial control of DNA break formation and repair

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract During meiosis, DNA double-strand breaks (DSBs) are formed at high frequency at special chromosomal sites, called DSB hotspots, to generate crossovers that aid proper chromosome segregation. Multiple chromosomal features affect hotspot formation. In the fission yeast S. pombe the linear element proteins Rec25, Rec27 and Mug20 are hotspot determinants – they bind hotspots with high specificity and are necessary for nearly all DSBs at hotspots. To assess whether they are also sufficient for hotspot determination, we localized each linear element protein to a novel chromosomal site (ade6 with lacO substitutions) by fusion to the Escherichia coli LacI repressor. The Mug20-LacI plus lacO combination, but not the two separate lac elements, produced a strong ade6 DSB hotspot, comparable to strong endogenous DSB hotspots. This hotspot had unexpectedly low ade6 recombinant frequency and negligible DSB hotspot competition, although like endogenous hotspots it manifested DSB interference. We infer that linear element proteins must be properly placed by endogenous functions to impose hotspot competition and proper partner choice for DSB repair. Our results support and expand our previously proposed DSB hotspot-clustering model for local control of meiotic recombination.