jimnoneill/paper-to-field-training huggingface dataset:
Response of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) with nongerminal center B-cell phenotype to lenalidomide (L) alone or in combination with rituximab (R).

Field: Medicine (Health Sciences)

8038 Background: Novel salvage therapies for relapsed/refractory (r/r) DLBCL and the identification of specific biomarkers predictive of response to a specific therapy are needed. L has an overall response rate (ORR) of 28% in r/r DLBCL. Methods: We retrospectively evaluated differences in clinical outcomes for germinal center B-cell (GCB)-like vs non-GCB-like DLBCL patients treated with salvage L alone (RPCI) or L+R (DHOS-S). We are augmenting the current database with pathology specimens from r/r DLBCL patients treated with L monotherapy at the Mayo Clinic and Hackensack Cancer Center. The initial data set from RPCI included 18 patients with r/r large cell lymphoma: 8M/10F; median age: 64 yrs; median 4 prior treatments. Patients were classified as GCB (n=9) or non-GCB (n=9) using the Hans criteria. Differences in overall response rate (ORR), CR or PR rates, progression-free survival (PFS), and overall survival (OS) were compared between GCB and non-GCB DLBCL. Results: No differences in stage, international prognostic index (IPI) score, prior number of treatments, were noted between the two groups. A significant difference in clinical response to L was observed: ORR was 77% for non-GCB patients vs 11% for GCB patients (P=0.011); and 44% of non- GCB patients achieved a CR vs 11% of patients with the GCB phenotype. PFS for patients with the non-GCB subtype was 336 days vs 72 days for patients with the GCB subtype (P=0.008). Although, median OS for the non-GCB subgroup was 420+ days compared with 73 days for GCB patients, it did not reach statistical significance (P=0.4). In a separate analysis, an additional 8 patients with r/r DLBCL (all non-GCB subtype), treated at the DHOS-S with L+R, achieved an ORR of 50%. This appears to be favorable relative to historical controls. Conclusions: Our data suggests that these two subgroups of patients with DLBCL (i.e. GCB vs non-GCB) appear to have a significantly different response to L in the r/r setting. Results from the analysis of the expanded data set are anticipated in time for the congress, and a large international trial is in development in an attempt to prospectively validate our findings. No significant financial relationships to disclose.
The Role of the Creative Process in Holding and Facilitating Traumatic Experience

Field: Psychology (Social Sciences)

Dissociative self states related to early traumatic experience may be elicited through the creative act, visual images, dreams, enactments, and affective collisions in the analytic dyad. In the following article, the author will describe her work with a visual artist and how the creative process, along with affect sharing and facilitation, helped open pathways to hold and communicate traumatic memories and self states.
Inhibition of lecithin-cholesterol acyltransferase by diphytanoyl phosphatidylcholine.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Model high density lipoproteins containing human apolipoprotein A-I, cholesterol, and a variety of phosphatidylcholines (PCs) have been prepared and tested. The PCs included 1-palmitoyl-2-oleoyl PC (POPC) and its diether analog 1-O-hexadecyl-2-oleyl PC (POPC ether), 1,2-diphytanoyl PC (DPhPC), 1-palmitoyl-2-phytanoyl PC, and 1-phytanoyl-2-palmitoyl PC. All ester PCs were good acyl donors for the transesterification of cholesterol catalyzed by human lecithin-cholesterol acyltransferase except DPhPC, which showed no reactivity. The PCs containing one phytanoyl chain donated an acyl chain to cholesterol as fast as non-branched fatty acyl chains. However, the competitive inhibition of lecithin-cholesterol acyltransferase by POPC ether and DPhPC was similar, and both lipids formed a macromolecular matrix that supported the reactivity of other ester PC substrates. The bulk of physicochemical properties of model high density lipoproteins composed of DPhPC were indistinguishable from those of POPC ether. These properties included 1) alpha-helical content of the apoprotein as assessed by circular dichroism, 2) microviscosity as determined from the fluorescence polarization and lifetime of the probe 1,6-diphenyl-1,3,5-hexatriene, 3) macromolecular weight based upon analytical gel filtration chromatography, and 4) surface polarity revealed by the fluorescence of 6-propionyl-2(dimethylamino)naphthalene. The only major difference in a physicochemical property was that the molecular surface area of DPhPC (area = 69 A2 at collapse pressure) determined by monolayer methods was 17 A2 greater than that of POPC (area = 53 A2 at collapse pressure) at all surface pressures measured. We suggest that the properties of DPhPC in being enzymatically nonreactive but a competitive inhibitor are due to its much larger size and that the active site of lecithin-cholesterol acyltransferase cannot bind phospholipid substrates in a catalytically productive way if they have surface areas of 70 A2 or more.
Atrovirinone inhibits pro‐inflammatory mediator release from murine macrophages and human whole blood

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Many plant‐derived natural compounds have been reported previously to inhibit the production of important pro‐inflammatory mediators such as nitric oxide, prostaglandin E 2 , TNF‐α and reactive oxygen species by suppressing inducible enzyme expression via inhibition of the mitogen‐activated protein kinase pathway and nuclear translocation of critical transcription factors. This study evaluates the effects of atrovirinone [2‐(1‐methoxycarbonyl‐4,6‐dihydroxyphenoxy)‐3‐methoxy‐5,6‐di‐(3‐methyl‐2‐butenyl)‐1,4‐benzoquinone)], a benzoquinone that we have previously isolated from Garcinia atroviridis , on two cellular systems that are repeatedly used in the analysis of anti‐inflammatory bioactive compounds, namely, RAW 264.7 macrophage cells and whole blood. Atrovirinone inhibited the production of both nitric oxide and prostaglandin E 2 from LPS‐induced and IFN‐γ‐induced RAW 264.7 cells and whole blood, with inhibitory concentration (IC) 50 values of 4.62 ± 0.65 and 9.33 ± 1.47 μmol/L, respectively. Analysis of thromboxane B 2 (TXB 2 ) secretion from whole blood stimulated by either the cyclooxygenase (COX)‐1 or the COX‐2 pathway showed that atrovirinone inhibits the generation of TXB 2 by both pathways, with IC 50 values of 7.41 ± 0.92 and 2.10 ± 0.48 μmol/L, respectively. Analysis of IC 50 ratios showed that atrovirinone was more COX‐2 selective in its inhibition of TXB 2 , with a ratio of 0.32. Atrovirinone also inhibited the generation of intracellular reactive oxygen species and the secretion of TNF‐α from RAW 264.7 cells in a dose‐responsive manner, with IC 50 values of 5.99 ± 0.62 and 11.56 ± 0.04 μmol/L, respectively. Lipoxygenase activity was also moderately inhibited by atrovirinone. Our results suggest that atrovirinone acts on important pro‐inflammatory mediators possibly by the inhibition of the nuclear factor‐κB pathway and also by the inhibition of the COX/lipoxygenase enzyme activity.
S862 THE ROLE OF GATA2 IN HSC GENERATION THROUGH ENDOTHELIAL‐TO‐HEMATOPOIETIC TRANSITION.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Background: GATA2 is the most frequently mutated gene in childhood AML. These patients have germline mutations in one allele of GATA2 and have a high predisposition for MDS/AML. Also, in mouse, Gata2 is required for embryonic HSC generation and survival and complete deletion of Gata2 is lethal at embryonic day (E)10, while Gata2 haploinsufficiency results in a severe reduction in the formation of HSCs. The first HSCs are formed at E10.5 through a process called endothelial‐to‐hematopoietic transition (EHT) from specialized hemogenic endothelial cells of the dorsal aorta in the aorta‐gonad‐mesonephros (AGM) region. Aims: As all patients suffering from GATA2 haploinsufficiency syndromes have innate GATA2 mutations, our hypothesis is that embryonic haploinsufficiency of GATA2 is responsible for the phenotype of the patients. Therefore, we want to understand how Gata2 haploinsufficiency affects the generation of HSCs through EHT. Methods: We sorted phenotypic HSPCs (CD31 + cKit + cells) from WT and Gata2 +/‐ E11 AGMs and performed transcriptome analysis. Also, with whole‐mount antibody staining performed on the WT and Gata2 +/‐ AGMs, we analysed CD31 + cKit + cell populations. Results: Surprisingly, we found that the hematopoietic transcriptional program is not abrogated in Gata2 +/‐ mouse E11 CD31 + cKit + cells. However, Gata2 +/‐ HSPCs still express the endothelial program indicating that the hematopoietic cells are stuck in the endothelium and cannot complete EHT. We found that Gfi1b is downregulated in Gata2 +/‐ HSPCs. As Gfi1b is known to be required for downregulation of the endothelial program for EHT during primitive hematopoiesis, we hypothesize that Gata2 directly regulates Gfi1b and that this regulation is required for normal EHT. Summary/Conclusion: In conclusion, we showed Gata2 +/‐ HSPCs are transcriptionally different from WT HSPCs. We are currently studying if a specific HSPC subtype can overcome Gata2 haploinsufficiency and will still undergo EHT as this may have implications for the hematopoietic cells that eventually populate the hematopoietic tissues.
The 12-Month Administration of Tofogliflozin for Glycemic Control with Monitoring Electrolytes, Renal and Cardiac Function in Japanese Elderly Patients with Type 2 Diabetes Mellitus

Field: Medicine (Health Sciences)

Abstract Objective: Tofogliflozin, a new class of glucose-lowering drugs, acts on sodium glucose cotransporter 2 locating on proximal
tubules of kidney, excreting excessive glucose by inhibiting the transporter. Due to its mechanism of osmotic diuresis, monitoring
of electrolyte and dehydration is important. The present study investigated a time-dependent change of these variables in
elderly people. Methods: The treatment was conducted in 81 elderly patients with type 2 diabetes mellitus receiving tofogliflozin for 12
months. Glycated hemoglobin (HbA1c), serum electrolytes (sodium, potassium, chloride) and hematocrit as an index of
dehydration were continuously monitored during the investigation period. Results: HbA1c significantly decreased (β1=7.26, β0= − 0.04, p<0.01, by linear regression analysis). Electrolytes, including
sodium, and chloride, significantly changed throughout the investigation period.And heamtocrit potassium,eGFR,and BNP did
not change throughout the period. Conclusion: A twelve-month administration of tofogliflozin improved glycemic control in type 2 diabetic patients without
aggravating the abnormality of serum electrolyte concentration and hematocrit values. This study suggested that 12-month
administration of tofogliflozin exhibited glucose-lowering with less risk of drug-induced electrolyte abnormalities, dehydration
and aggravating BNP level in elderly patients with type2 diabetes mellitus. Keywords BNP; Elderly Patients; Electrolyte; HbA1c; SGLT2 Inhibitor; Tofogliflozin
mpression Management Tactics in the Workplace: Enhancing or Compromising the Employee Performance?

Field: Psychology (Social Sciences)

Employees use impression tactics to create a specific self-image in the workplace, consciously or unconsciously. Such tactics have been classified into positive and negative tactics, with the former including self-promotion, ingratiation, and exemplification, and the latter including intimidation and supplication. Positive tactics generally lead to favorable outcomes, for instance, high-performance ratings, while negative tactics lead to the opposite. However, categorizing impression management tactics into positive and negative may not be entirely accurate, and our research findings challenge this traditional classification. An online self-report measure survey was implemented, involving 313 employees working in government and private organizations in Bengkulu, Indonesia. Hypothesis testing using Hierarchical Regression Analysis revealed that impression management tactics strongly affect contextual performance, followed by task and adaptive performance. In particular, our research findings indicate that self-promotion tactics hurt adaptive performance, while ingratiation tactics positively affect task, adaptive, and contextual performance. Exemplification tactics positively affect task performance and contextual performance, while intimidation tactics negatively affect task, adaptive, and contextual performance. Supplication tactics, on the other hand, negatively affect task performance and contextual performance but positively impact adaptive performance.
The study of antibacterial activity of some plant extracts against causes of pneumonia

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Eighty five samples were taken from patients suffering from pneumonia. Seventy-eight isolates were diagnosed as following: Staphylococcus aureus (23), klebsiella pneumoniae (29), Streptococcus pneumoniae (15), Serratia sp. (4), Haemophilus influenzae (4) and Pseudomonas aeruginosa (3). The clinical isolates were tested for antibiotics sensitivity. They appeared highly resistance to penicillin G and Ampicillin at percentage 89.7 and 84.6% respectly while the results showed highly sensitivity to streptomycin at percentege of (12.8%). To study the antibacterial activity of Alium sativum, Eucalyptus microtheca leaves and Cydonia oblonga seeds extracts, five multi resistant strains were used by using agar well diffusion and disk methods at concentrations of (24, 12, 6, 3)%. The agar well diffusion was prefered for both of Alium sativum and Eucalyptus microthesca extracts while both methods were prefered for Cydonia oblonga extract by measuring inhibition zones .The results showed antibacterial activity of Alium sativum on S.aureus and S. pneumoniae at concentration 3-24 % and for klebsiella pneumoniae at concentration of 6-24%While it was 12-24%for Serratia sp. and Pseudomonas aeruginosa. Eucalyptus microtheca extracts showed antibacterial at concentration of 24-3%for S.aureus, S. pneumoniae and Ps. aeruginosa. While K. pneumoniae and Serratia sp sensitive at concartatins of 24%. The ethanol and oil extracts of Cydonia oblonga seeds had anti bacterial activity at all concentrations for all strains except Serratia sp. showed sensitivity at concentrations of 24-6%for both extracts.
Molecular analysis of grapevine Pinot gris virus and its association with grapevine leaf mottling and deformation on ‘Vermentino’ grapevines in Sardinia

Field: Agricultural and Biological Sciences (Life Sciences)

In 2017–2018, grapevines of cultivar ‘Vermentino’ infected with grapevine Pinot gris virus (GPGV) in Sardinia, Italy, exhibited leaf symptoms of mosaic, chlorotic mottling, and curling, and stunted shoots. Disease incidence assessed in 2018 was greater (67%, 103 symptomatic plants out of 153 monitored) than in 2017 (26%, 40 of 153 plants). All symptomatic samples tested by RT-PCR were positive for GPGV in both years, while 70% (53 of 76) of the asymptomatic samples in 2017, and 42% (19 of 45) in 2018, were also positive for GPGV. Characterizing six GPGV isolates from ‘Vermentino’ by RT-PCR and sequencing of a genomic fragment covering the movement and coat protein genes showed high conservation at the nucleotide level (98.7% to 100.0%) among Sardinian isolates and isolates for which sequence information is available in GenBank. Phylogenetic analysis indicated that most Sardinian GPGV isolates grouped with other European isolates. This is the first characterization of GPGV in a Sardinian vineyard.
Cloning, Synthesis and Functional Characterization of a Novel α-Conotoxin Lt1.3

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

α-Conotoxins (α-CTxs) are small peptides composed of 11 to 20 amino acid residues with two disulfide bridges. Most of them potently and selectively target nicotinic acetylcholine receptor (nAChR) subtypes, and a few were found to inhibit the GABAB receptor (GABABR)-coupled N-type calcium channels (Cav2.2). However, in all of α-CTxs targeting both receptors, the disulfide connectivity arrangement “C1-C3, C2-C4” is present. In this work, a novel α4/7-CTx named Lt1.3 (GCCSHPACSGNNPYFC-NH2) was cloned from the venom ducts of Conus litteratus (C. litteratus) in the South China Sea. Lt1.3 was then chemically synthesized and two isomers with disulfide bridges “C1-C3, C2-C4” and “C1-C4, C2-C3” were found and functionally characterized. Electrophysiological experiments showed that Lt1.3 containing the common disulfide bridges “C1-C3, C2-C4” potently and selectively inhibited α3β2 nAChRs and not GABABR-coupled Cav2.2. Surprisingly, but the isomer with the disulfide bridges “C1-C4, C2-C3” showed exactly the opposite inhibitory activity, inhibiting only GABABR-coupled Cav2.2 and not α3β2 nAChRs. These findings expand the knowledge of the targets and selectivity of α-CTxs and provide a new structural motif to inhibit the GABABR-coupled Cav2.2.
Predictability and Effectiveness of Nuvola® Aligners in Dentoalveolar Transverse Changes: A Retrospective Study

Field: Dentistry (Health Sciences)

Nowadays, many people use clear aligners to address their dental issues. The efficacy of transparent dental aligners must be investigated even though they are more aesthetically pleasing, easy to use, and tidy than permanent tools. Thirty-five patients in this study’s sample group who used Nuvola® clear aligners for their orthodontic therapy were prospectively observed. Initial, simulated, and final digital scans were analysed with a digital calliper. The actual results were compared with the prescribed ending position to evaluate the efficacy of transversal dentoalveolar expansion. Aligner treatments in Groups A (12) and B (24), particularly in the dental tip measures, demonstrated high adherence to the prescription. On the other hand, the gingival measures exhibited a greater level of bias, and the differences were statistically significant. However, there was no difference in the outcomes between the two groups (12 vs. 24). Within specific parameters, the evaluated aligners were shown to be helpful in predicting movements in the transverse plane, particularly when considering movements linked to the vestibular–palatal inclination of the dental elements. This article compares the expansion effectiveness of Nuvola® aligners compared with other work in the literature using competitor companies.
Robust pitch estimation using an optimal filter on frequency estimates

Field: Computer Science (Physical Sciences)

In many scenarios, a periodic signal of interest is often contaminated by different types of noise that may render many existing pitch estimation methods suboptimal, e.g., due to an incorrect white Gaussian noise assumption. In this paper, a method is established to estimate the pitch of such signals from unconstrained frequency estimates (UFEs). A minimum variance distortionless response (MVDR) method is proposed as an optimal solution to minimize the variance of UFEs considering the constraint of integer harmonics. The MVDR filter is designed based on noise statistics making it robust against different noise situations. The simulation results confirm that the proposed MVDR method outperforms the state-of-the-art weighted least squares (WLS) pitch estimator in colored noise and has robust pitch estimates against missing harmonics in some time-frames.
Ingestion of topical steroid triggering pustular psoriasis?

Field: Medicine (Health Sciences)

Conflicts of interest: none declared. Sir, A 7‐year‐old girl was admitted as an emergency under the care of the paediatricians, with painful erythroderma, systemic upset and pyrexia of up to 40 °C. She had a history of special educational needs and hyperactive behaviour, and had previously been treated for psoriasis by her general practitioner (GP), although she had not needed to use any topical therapy for 6 months. There was a strong family history of psoriasis, with both her mother and her maternal grandmother affected. Seven days prior to admission she had ingested more than half of a 100‐g tube of clobetasone butyrate (Eumovate®; GlaxoSmithKline, Uxbridge, U.K) belonging to her mother. Forty‐eight hours after this she began to develop redness and scaling initially on the face and subsequently on the lower limbs. When the GP was consulted the following day pustules were noted, and oral flucloxacillin suspension 125 mg four times daily was commenced along with topical Aqueous Cream. Despite these measures the rash became more widespread, resulting in admission.
LHD cECE #135119.1

Field: Physics and Astronomy (Physical Sciences)

The electron cyclotron emission (ECE) imaging to determine the electron temperature profile by measuring the intensity of each frequency of ECE. This system uses a wide-band two-dimensional horn-antenna mixer array (HMA) whose frequency response is between 50 and 110 GHz and the ECE signal is selected using a 95 GHz local oscillator and a 93 GHz high-pass filter.
Laterality effects in the spinning dancer illusion: The viewing‐from‐above bias is only part of the story

Field: Psychology (Social Sciences)

The ‘silhouette illusion’, representing the silhouette of a female dancer pirouetting about her vertical axis, is a bistable stimulus created by Japanese web designer Nobuyuki Kayahara. Although the dancer can be perceived as spinning either clockwise or counterclockwise, the clockwise rotation is usually preferred. Troje and McAdam ( i‐Perception , 2010, 1, 143) showed that this clockwise bias can be attributed to the tendency to assume a viewpoint from above rather than from below, given that the dancer is portrayed from a vantage point that is not perpendicular to the axis of rotation. Here, we tested whether another possible factor contributing to the observers’ interpretation of this bistable stimulus might be the tendency to perceive movements of the right rather than the left foot. We confirmed both the viewing‐from‐above bias and our hypothesis. The bias to perceive movements of the right leg might be a generalization to lower limbs of a perceptual frequency effect already observed for upper limbs. Such a perceptual and attentional bias towards the right hand/foot could account for the greater ability to predict the outcome of sport actions when observing right‐ rather than left‐limbed movements, and thus the left‐handers' and left‐footers' advantage observed in a variety of interactive sports.
Duobrachium Ford & Bezio & Collin 2020, gen. nov

Field: Agricultural and Biological Sciences (Life Sciences)

Genus Duobrachium gen. nov. Diagnosis. Tentaculate cydippid ctenophores with two thick, aboral, conical tentacle arms. Tentacle arms emerge from the center of the body and extend aborally. Body rectangular in the tentacular plane, oblong in the stomodeal plane. The tentacle arms are as long as the body is tall. Tentacles retractile, with simple tentilla of uniform length. Filaments can exit orally, anchoring it to the sediment. Stomodeum darkly pigmented. Gonads globular, not extending the length of the meridional canals. Type species. Duobrachium sparksae n. sp., described herein. Etymology. From the Latin “two-arms”, a name reflecting the two prominent arms. The Latin “brachium” is of common gender, but shall be treated as feminine, in accordance with ICZN article 30.1.4.2.