jimnoneill/paper-to-field-training huggingface dataset:
Social Work Best Practices in Schools: Effect of Family-Focused Case Management on Rural School Students’ Success

Field: Social Sciences (Social Sciences)

Rural families and children have historically been challenged by a lack of public investment in their communities. Over generations, such deprivation created cycles of pervasive, persistent behavioral health and well-being disparities that negatively impact contemporary families and children, and threaten the socioeconomic future of America (Branson, 2019; Showalter et al., 2019; U.S. Department of Health and Human Services, n.d.). The purpose of this dissertation was to build a model of school social work best practices employing strategies intended to break cycles of unmet needs by reducing social determinant of health (SDOH) risks in rural environments, thereby enhancing the health and well-being of families, and the children in their care. This work integrated current knowledge and advancements from multiple fields of study to forge innovations in practice supported by the foundational framework set forth by the School Social Work Association of America ([SSWAA], n.d.). The best practices model was piloted in five elementary schools in three rural school districts in northeastern Pennsylvania (N = 1,727). A quasi-experimental, nonequivalent control group design was used to examine the effects of family-focused case management (FFCM) on student success. At the end of the first phase of this longitudinal community-based action research (CBPR) project (one public school trimester averaged 56 days), inferential statistics found no significant differences in the sample (n = 95) between the experimental group of youth whose family voluntarily participated in FFCM (n = 13) and the control group of youth whose family did not voluntarily participate in FFCM (n = 82). Barriers to implementing the model’s best practices of multisystem practice (MSP), family-in-environment (FIE), and planned change process (PCP) included lack of funding to achieve appropriate provider–student ratios in the high need, post-COVID-19 era and ideologies discounting families as a pivotal social institution. Provider shortages obstructed the inclusion of families in service offerings and the use of upstream prevention programs critical to reducing SDOH risk factors from the convenient hub of rural schools. Study implications and recommendations for future research are offered.
SAT-456 Reduced Cholesterol Absorption and Synthesis Markers in Patients with Hyperthyroidism Due to Graves’ Disease

Field: Medicine (Health Sciences)

Abstract Background:Thyroid hormones have been reported to promote cell-surface expression of low-density lipoprotein receptor (LDL-R), and also increase mRNA expression of HMG-CoA reductase at the same time. Since LDL cholesterol (LDL-C) uptake via LDL-R is relatively superior to cholesterol synthesis in hyperthyroidism, plasma LDL-C levels can be lower as compared to euthyroid state. Conversely, hypothyroidism can increase plasma LDL-C levels because cholesterol absorption via Niemann-Pick C1-like 1 has been suggested to increase in hypothyroidism. However, there have been no reports about changes of cholesterol absorption and synthesis markers by the treatment of hyperthyroidism in patients with Graves’ disease. Patients and method: We collected plasma samples from patients with hyperthyroidism, who were diagnosed as Graves’ disease (n=17, M/F: 4/13, age: 24-70 years old). Thyroid hormones, general lipid profiles (Total cholesterol: TC, LDL-C, high-density lipoprotein cholesterol: HDL-C and triglyceride: TG), apolipoproteins, markers of cholesterol synthesis (lathosterol) and absorption (campesterol, sitosterol, cholestanol), lipoprotein lipase (LPL), and proprotein convertase subtilisin/kexin type 9 (PCSK9) were analyzed before treatment, and at euthyroid state (eu), 3 and 6 months after attaining euthyroid state (eu-3M and eu-6M). Result: It took 159.2±108.6 days to attain euthyroid state by the thiamazole treatment. TC, LDL-C and HDL-C levels were increased at eu (TC, 144.5±26.7 to 225.0±61.6; LDL-C, 77.8±20.9 to 138.9±43.9; HDL-C, 49.7±12.6 to 67.9±20.0 mg/dL: P&lt;0.0001 vs before treatment, respectively). Such changes remained at eu-3M and eu-6M. TG was not changed at eu, but significantly increased at eu-6M (85.0±49.1 to 113.7±60.8 mg/dL, P=0.02). Cholesterol absorption markers were increased at eu, eu-3M and eu-6M (e.g. campesterol, 2.6±1.2 to 4.9±2.3; sitosterol, 1.5±0.6 to 2.9±1.4; cholestanol, 1.9±0.6 to 3.2±1.1 μg/mL: P&lt;0.0001, eu vs before treatment, respectively). Cholesterol synthesis marker was increased at eu, eu-3M and eu-6M (e.g. lathosterol, 1.8±0.7 to 2.3±0.9 μg/mL: P=0.005, eu vs before treatment). Both LPL and PCSK9 were also increased at eu, eu-3M and eu-6M. Conclusion: These data suggest that both cholesterol absorption and synthesis are downregulated in patients with hyperthyroidism due to Graves’ disease and can be restored by attaining euthyroid state. In turn, LDL-C and TG levels should be carefully monitored during the treatment of Graves’ disease because hyperlipidemia could emerge in euthyroid state.
The art of war: examining the visual narratives of Ukrainian video games

Field: Arts and Humanities (Social Sciences)

This article focuses on the visual narratives of Ukrainian war-themed video games, analysing how they depict the Russia-Ukraine war and contribute to the national narrative of resistance and resilience. Using cultural, structuralist and critical approaches, the research examines the portrayal of cultural heroes, chronotypes, values, and carnival mechanisms in these visual narratives. This article analyses how visual elements in Ukrainian video games reflect and respond to contemporary socio-political realities and how Ukrainian game developers navigate the complexities of their nation's history, memory, and identity while contributing to ongoing discourses surrounding resistance and resilience. The study identifies key Ukrainian narratives: the sanctity of Ukraine's borders (map), new war topos, and the invasion-centred timeline; Ukraine's global mission against evil; individual contributions to national victory; and the carnivalesque nature of the Ukrainian culture. Computer game narratives deconstruct enemy propaganda, highlight Ukraine's resilience, and inform the global community about events in Ukraine.
Data from A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

<div>Abstract<p>Standard therapies used for the treatment of acute myeloid leukemia (AML) are cytotoxic agents that target rapidly proliferating cells. Unfortunately, this therapeutic approach has limited efficacy and significant toxicity and the majority of AML patients still die of their disease. In contrast to the poor prognosis of most AML patients, most individuals with a rare subtype of AML, acute promyelocytic leukemia, can be cured by differentiation therapy using regimens containing all-trans retinoic acid. GSK3 has been previously identified as a therapeutic target in AML where its inhibition can lead to the differentiation and growth arrest of leukemic cells. Unfortunately, existing GSK3 inhibitors lead to suboptimal differentiation activity making them less useful as clinical AML differentiation agents. Here, we describe the discovery of a novel GSK3 inhibitor, GS87. GS87 was discovered in efforts to optimize GSK3 inhibition for AML differentiation activity. Despite GS87's dramatic ability to induce AML differentiation, kinase profiling reveals its high specificity in targeting GSK3 as compared with other kinases. GS87 demonstrates high efficacy in a mouse AML model system and unlike current AML therapeutics, exhibits little effect on normal bone marrow cells. GS87 induces potent differentiation by more effectively activating GSK3-dependent signaling components including MAPK signaling as compared with other GSK3 inhibitors. GS87 is a novel GSK3 inhibitor with therapeutic potential as a differentiation agent for non-promyelocytic AML. <i>Mol Cancer Ther; 15(7); 1485–94. ©2016 AACR</i>.</p></div>
Coinfection of Specific-Pathogen-Free Chickens with Marek's Disease Virus (MDV) and Chicken Infectious Anemia Virus: Effect of MDV Pathotype

Field: Veterinary (Health Sciences)

Both Marek's disease virus (MDV) and chicken infectious anemia virus (CIAV) infections are prevalent in chickens throughout the world. In the past decade, MDV strains with increased virulence (very virulent plus MDV pathotype [vv+MDV]) have been isolated. The purpose of this experiment was to determine the effects of coinfection of chickens with CIAV and a vv+MDV isolate. Specific-pathogen-free chickens were inoculated at 1 day posthatch with RB1B (very virulent MDV pathotype [vvMDV]) only, 584A (vv+MDV) only, CIAV only, RB1B + CIAV, 584A + CIAV, or nothing. Samples of spleen, thymus, and bursa of Fabricius were collected at 4, 7, 10, and 13 days postinoculation (DPI). Thymic and bursal atrophy at 13 DPI and final mortality at 30 DPI were significantly greater in chickens inoculated with 584A with or without added CIAV, or with RB1B plus CIAV, compared with birds inoculated with RB1B alone. Both amounts of virus reisolated and levels of virus detected by quantitative-competitive polymerase chain reaction were greater at 4 DPI in 584A inoculates compared with RB1B inoculates. To monitor the early cytolytic infection, northern analysis was done with a probe for the MDV immediate early gene ICP4 (infected cell protein 4). In the absence of CIAV, ICP4 expression was more apparent in chickens inoculated with 584A than in those inoculated with RB1B. CIAV coinfection increased ICP4 expression in the spleens of chickens infected with RB1B. These results indicated that inoculation of chickens with the 584A isolate caused a more robust early cytolytic infection compared with inoculation with RB1B alone and support the classification of 584A as a vv+MDV strain. Coinfection with CIAV exacerbated vvMDV strain RB1B infection. The extent of this exacerbation was less evident when birds were coinfected with 584A and CIAV.
Design of Transmission Device for Spherical Parts Processing in CA6140 Horizontal Lathe

Field: Engineering (Physical Sciences)

In order to enable ordinary horizontal lathe to process bigger size and higher precision sphere parts,a kind of transmission device is designed in CA6140 horizontal lathes,and the working principle and processing method of the device is described.It was verified by enterprise to have good effect including more processing range,convenient operation,easy installation,adjustment and remove,safe and reliable.
Incorporation of Jute Fiber in Concrete: A Literature Review

Field: Engineering (Physical Sciences)

Abstract: This systematic literature review delves into the incorporation of jute fiber as a reinforcement material in concrete, examining its benefits, challenges, and potential applications. Jute fiber, a natural and biodegradable material, presents an eco-friendly and cost-effective alternative to synthetic fibers commonly used in concrete reinforcement. The utilization of jute fibers in concrete not only enhances its mechanical properties but also promotes sustainable construction practices, addressing the growing need for environmentally responsible building materials. The review synthesizes existing research on the physical, mechanical, and durability properties of jute fiber-reinforced concrete (JFRC). It explores how the unique characteristics of jute fibers, such as their high tensile strength and low density, contribute to improved concrete performance, particularly in terms of tensile and flexural strength. The addition of jute fibers helps mitigate crack propagation and enhances the ductility of concrete, making it more resilient to dynamic loads. Despite these benefits, challenges such as the hydrophilic nature of jute fibers, which can lead to increased water absorption and potential durability issues, are also addressed. Various chemical treatments and surface modifications have been explored to improve the compatibility of jute fibers with the cement matrix and enhance the overall durability of JFRC
Income Inequality and the Strength of the Origins-Health Gradient in 20 European Countries

Field: Social Sciences (Social Sciences)

Health is determined by socio-economic position not only of the individual, but also by that of their parents. The intergenerational transmission of health via parental socioeconomic status is suggested to vary according to contextual factors such as income inequality. Earlier studies with a comparative perspective had a limited number of countries available. This study uses 20 countries at up to five waves from the European Social Survey (2008-2016) and SWIID in order to examine the extent to which income inequality is related to the origins-health gradient. The higher the income inequality of a given country and year, the stronger the origins-health gradient. Contrary to earlier findings, this association can be fully explained by intergenerational transmission of status, i.e. education. Implications of this finding are that health is largely determined by educational attainment and associated health behaviors, giving societal context a less prominent role than earlier studies suggested.
Effective Search for a Buried Layer: An Approach to Experimental Design in Geophysics

Field: Earth and Planetary Sciences (Physical Sciences)

A practical method of solution is developed of some design and analysis problems of geophysical surveys. Starting with quantitative measures of parameter resolution in general models, we derive expressions for parameter error bounds which are related to parameter resolution and measurement noise. The methods are applied to three problems involving buried layers: a deep permafrost layer which underlies a conductor, a buried electromagnetic waveguide, and a layer beneath the Moho. We assume that magnetotelluric data and several groups of DC resistivity measurements are available. For a realistic level of data inaccuracy it is shown that both DC and MT data are essential to resolve resistivity in the waveguide. DC data may be helpful in the deep permafrost case. They add no information in the Moho model. This approach can be used to select methods for a wider variety of geophysical problems, including those of exploration and engineering. It also suggests that existing data, as for example those acquired in the waveguide search, might be reevaluated to good effect.
Transport of fast electrons during LHCD in TS, JET, and ASDEX

Field: Physics and Astronomy (Physical Sciences)

A review of fast electron dynamic studies in the tokamaks TS, JET, and ASDEX during lower hybrid current drive is presented. In almost all experiments, the collisional slowing down is predominant, so a straightforward assessment of the fast electron radial transport is difficult, especially for large size tokamaks. From recent LH power modulation experiments performed on TS at low density, the fast electron diffusion coefficient, Dst, is found between 0.1-0.3m2s-1, close to the value determined on ASDEX in similar plasma conditions. An estimate of Dst is also obtained in TS and JET by modeling the plasma dynamics, using ray-tracing+Fokker-Planck codes. For JET, the fast electron transport is fully taken into account in the Fokker-Planck equation. Despite some quantitative discrepancies between Dst values determined from different methods, the diffusion rate of the fast electrons is weak enough for current profile control scenarii to be relevant on large tokamaks. A determination of the type of the turbulence - electrostatic or magnetic - that could drive the radial transport of fast electrons requires finer LH experiments.
Networks of inventors in the chemical industry

Field: Business, Management and Accounting (Social Sciences)

By using extremely detailed data on European chemical patents, this work focuses on the micro level of research networks. It examines the networks of inventors for the development of innovations. It studies whether the firm or the geographical proximity among inventors influences the probability that inventors collaborate, and the attributes of the outcome patents. The results suggest that the firm, and in particular the large multinational company is a good coordination mechanism for fostering such collaborations. As for geographical proximity, it matters when the inventors are localised in a technological cluster.
Bromadiolone paraffin blocks not-exposed and exposed to the environment.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

This paper evaluated the attractibility, palatability and efficacy of bromadiolone paraffin block exposed for 30 days to environmental conditions. It was used four groups of white Wistar rats: two groups received no-exposed blocks (control group) and two groups received blocks exposed for 30 days to the environment; in both cases, one of the groups received just the block and the other group received parafin block and food. The tests were repeated after 2 months. The quantity of block consumed and the mortality of the animals were registered. Despite the changed appearance of the blocks after exposure, there was no significant difference between the consumption of the no-exposed and the exposed blocks. Blocks were consumed only in groups that received just the blocks, indicating low attractiveness of the product, although it was effective, killing 80-100% of animals. There was no change in the attractibility, palatability and efficacy of bromadiolone paraffin block after environmental exposure for 30 days.
Workflow for Off-Site Bridge Inspection Using Automatic Damage Detection-Case Study of the Pahtajokk Bridge

Field: Engineering (Physical Sciences)

For the inspection of structures, particularly bridges, it is becoming common to replace humans with autonomous systems that use unmanned aerial vehicles (UAV). In this paper, a framework for autonomous bridge inspection using a UAV is proposed with a four-step workflow: (a) data acquisition with an efficient UAV flight path, (b) computer vision comprising training, testing and validation of convolutional neural networks (ConvNets), (c) point cloud generation using intelligent hierarchical dense structure from motion (DSfM), and (d) damage quantification. This workflow starts with planning the most efficient flight path that allows for capturing of the minimum number of images required to achieve the maximum accuracy for the desired defect size, then followed by bridge and damage recognition. Three types of autonomous detection are used: masking the background of the images, detecting areas of potential damage, and pixel-wise damage segmentation. Detection of bridge components by masking extraneous parts of the image, such as vegetation, sky, roads or rivers, can improve the 3D reconstruction in the feature detection and matching stages. In addition, detecting damaged areas involves the UAV capturing close-range images of these critical regions, and damage segmentation facilitates damage quantification using 2D images. By application of DSfM, a denser and more accurate point cloud can be generated for these detected areas, and aligned to the overall point cloud to create a digital model of the bridge. Then, this generated point cloud is evaluated in terms of outlier noise, and surface deviation. Finally, damage that has been detected is quantified and verified, based on the point cloud generated using the Terrestrial Laser Scanning (TLS) method. The results indicate this workflow for autonomous bridge inspection has potential.
Hypoxia-Inducible Factor -1 contributes to transcriptional regulation of Bcl2-adenovirus E1B 19KDa -interacting protein in hypoxic cortical neurons

Field: Neuroscience (Life Sciences)

PARP-1 has been identified as a major player in apoptotic pathways. Its excessive activation causes mitochondrial dysfunction, permeability, and AIF mitochondrion-to-nucleus translocation. It has been suggested that PARP-1 interacts indirectly with Bnip3, a mitochondrial pro-apoptotic factor. However, the mechanistic linkage is still not well understood. Our lab has shown that cytosolic/nuclear NAD+ depletion is a hallmark for PARP-1 over activation and inhibition of sirtuin activity. Specifically in my project, we think that PARP-1 induced- NAD+ depletion and sirtuin inhibition causes hyperacetylation of the α subunit of the transcription factor HIF-1 allowing increased HIF-1 binding to Bnip3 upstream promoter, and increased Bnip3 expression. Indeed, our PARP-1 Knock out neurons, MNNG and PJ34 treatment, chromatin immunoprecipitation, and HIF-1α loss of function studies strongly confirmed the necessity of HIF-1 to increase Bnip3 expression in hypoxia. Overall, our research suggests a role for HIF-1 in increasing PARP-1 dependent Bnip3 expression in hypoxic models.
Disability status and perceptions of employability by employers

Field: Social Sciences (Social Sciences)

The study discussed in this article used a correlational design to examine the discrepancies among employers' employability ratings of hypothetical job applicants with different disability statuses. A survey packet was mailed to a random sample of 1,000 employers selected from a national membership list of human resources professionals. The survey included a standardized measure for rating employers' impressions of job applicants' employability with respect to 22 key employment-related traits. Employers were asked to rate the job applicants' suitability for employment in a hypothetical administrative assistant position. Findings show that job applicants without a disability received the highest mean employability ratings. Job applicants with an acquired brain injury were rated substantially the same as those with schizophrenia. Implications for social work practice and research are discussed.
Development of a walking humanoid robot

Field: Engineering (Physical Sciences)

Humanoid robots are becoming more sophisticated with the exponential advancement in robotics technology and their usefulness extending beyond the usual menial tasks to fields such as services and healthcare. This project aims to develop a humanoid robot that can perform a simple yet complex task of walking by running through a sequence of motions. The ROBOTIS Darwin-Mini Robot was utilised for this project. An android application was also developed to allow remote control of the robot via Bluetooth connection.
A preliminary examination of the late Palæozoic folding in the Hunter River district, New South Wales

Field: Earth and Planetary Sciences (Physical Sciences)

Involved.(11) Outline of the Work.III.Details of the Results.(1) The Shortening of the Crust.(ii) The Height of the Folds.(iii) The Depth of the Deformed Earth Block.IV.Preliminary Discussion of the Results.V. Results Obtained from the Amended Section.(i) The Height of the Folds.(ii
Amphibolous weglarskae Dastych, a new addition to the Tardigrada of Iceland with an updated checklist of Icelandic species (Eohypsibiidae, Eutardigrada).

Field: Agricultural and Biological Sciences (Life Sciences)

During the examination of the extensive Tardigrada\ncollections held at the Royal Museums of Scotland,\nspecimens and sculptured eggs belonging to Amphibolus\nweglarskae (Dastych) were identified in the Morgan\nIcelandic collection. This species had not previously\nbeen reported from Iceland. A checklist of Icelandic\nTardigrada species is also provided.