jimnoneill/paper-to-field-training huggingface dataset:
Effects of ozone exposure on free radical signals in photosystem I and on chlorophyll fluorescence in green foxtail, Setaria viridis Beauv.

Field: Agricultural and Biological Sciences (Life Sciences)

The mechanism of Tropospheric ozone damage to plants is not well understood. A study to try and bridge that gap was carried out. Studies with a C-4 grass, Setaria viridis Beauv., green foxtail, treated with sine-wave exposures to O3 within the modified cavity of an electron paramagnetic resonance (EPR) spectrometer, permitted observation of the effects of exposure on both the free radical signals in photosystems I and II and on chlorophyll fluorescence attributable to photosystem II. Signal I (from P700 + in PSI) was stimulated by O3 suggesting an interference with electron flow. During exposure to O3, non-photochemical quenching (qN) decreased over time but remained higher than in the control while NPQ remained unchanged over time but also was consistently higher than in the control, suggesting impairment of electron flow. These observations together with the O3-induced increases in non-photochemical quenching and the changes in EPR signals are compatible with the suggestion that interference with water-splitting is a major consequence of exposure to O3. The level of Signal I in white light was approximately about twice that in far-red light, presumably because of a contribution by PSII light-harvesting to PSI in the bundle-sheath chloroplasts. Measurements of the relative levels of Signal I in white or far-red light may therefore provide a means of assessing the extent of such contributions in other C-4 species.
New Fractional Calculus Results for the Families of Extended Hurwitz-Lerch Zeta Function

Field: Mathematics (Physical Sciences)

In the area of fractional calculus of arbitrary order, integrals and derivatives are studied and used in various applications. In the theory of fractional differential and integral equations, the special functions of the higher transcendental function are very important. In this chapter, our aim is to present the systematic study of the generalized Saigo's hypergeometric fractional calculus operators to establish a number of key results for the families of extended Hurwitz-Lerch Zeta function defined by many authors, including (for example) Srivastava et al. [Integral Transform. Spec. Funct. 22(7), (2011), 487{506], Garg et al. [Algebras Groups Geom. 25 (2008), 311{319], Lin and Srivastava [Appl. Math. Comput. 154 (2004), 725{733] and Goyal and Laddha [Ganita Sandesh 11 (1997), 99{108]. The new (presumably) and useful (potentially) results that are obtained in this chapter have been expressed in terms of the I-function introduced by Rathie [28]. Since the extended Hurwitz-Lerch zeta function and generalized Saigo's hypergeometric fractional calculus operators are of very general nature, therefore on specializing the parameters, a large number of special cases involving Riemann-Liouville and Erdélyi-Kober fractional integral and differential operators and Hurwitz-Lerch zeta function have been expressed in terms of I-function and https://www.w3.org/1998/Math/MathML"> H ¯ https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781003368069/e37564ec-62a9-4ca6-84ef-69ab9c2b9ce0/content/UnEq0206-09.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/> -function, as our main findings.
Hydranencephaly in an infant with vascular malformations

Field: Medicine (Health Sciences)

Hydranencephaly is a condition in which cerebral hemispheres are absent and reduced to fluid-filled sacs in a normal skull. Numerous causes have been proposed. We report a male infant with hydranencephaly and congenital vascular malformations (port wine stains, generalized nevus flammeus, anomalous retinal vessels, and absent internal carotid flow). Magnetic resonance imaging of the brain showed absence of most of the cerebrum except for small portions of the occipital cortex and thalami. Magnetic resonance angiography showed flow within the vertebral and basilar arteries without internal carotid intracranial flow above the internal carotid petrous and cavernous portion. This is a report of cutaneous and retinal malformations associated with hydranencephaly. Vascular malformations of larger vessels (e.g., webbing of the carotid arteries and an absent internal carotid arterial system) have been observed in other infants with hydranencephaly, and are proposed to lead to brain destruction. The case reported herein supports the role of primary vascular malformations in the development of some cases of hydranencephaly.
PENERAPAN ANALISIS SWOT DAN ANALYTICAL \nNETWORK PROCESS (ANP) UNTUK STRATEGI \nPENGEMBANGAN OBJEK WISATA DI COBAN \nTALUN

Field: Decision Sciences (Social Sciences)

Coban Talun Tourism is a natural tourism located in Tulungrejo Village, Bumiaji District, Batu City. In Coban Talun tourism, there is a lack of promotion and less than optimal development to increase the attractiveness of visitors. This study has a purpose, namely to find out the right strategy for the development of Coban Talun tourism. Integrating methods can analyze internal and external factors that influence the development of Coban Talun tourism, and determine the priority of development strategies. In this study, the SWOT and ANP methods were used for data analysis. The SWOT method is used to analyze the strengths, weaknesses, opportunities, and threats that exist in Coban Talun, and the ANP method is used to determine priorities in the development of Coban Talun ecotourism. The results of the analysis of the SWOT and ANP methods, in SWOT a SWOT matrix is formed which can then be modeled for ANP which consists of 8 alternative strategies. The strategic priority results obtained from the results of the ANP method processing are the creation of new, more attractive tourist rides, and the addition of outbound area (SO1)
Accuracy of Three Screening Instruments in Identifying Preschool Children at Risk for Autism Spectrum Disorder

Field: Medicine (Health Sciences)

An efficient approach for screening and identifying children at risk for autism spectrum disorder (ASD) remains a pressing need. The aim of this exploratory study was to examine the ability of two general developmental screening tests to identify children at risk for ASD. We compared the accuracy of one general developmental screening instrument, Ages and Stages Questionnaires (ASQ), and one general social emotional screening instrument, the Ages and Stages Questionnaire: Social Emotional (ASQ:SE), with the Social Communication Questionnaire (SCQ), an ASD-specific screening instrument. Two hundred eight children between 36 and 66 months were recruited through 19 community ASD programs, websites, and magazines. The three screening instruments were given to 285 parent/child dyads with and without a diagnosis of ASD, online via a screening website linked to a university. Sixty-four children had been diagnosed with ASD and were receiving special education services (e.g., behavioral interventions) prior to their participation. The classification agreement of the ASQ (i.e., sensitivity = 84.38%, specificity = 81.45%) outperformed the other two screening instruments; classification agreement of the SCQ was sensitivity = 70.31% and specificity = 87.33%; and of the ASQ: SE, sensitivity = 82.81% and specificity = 72.40%. Agreement among the questionnaires ranged from moderate to strong as measured by Pearson Product Moment Correlation Coefficients. Children diagnosed with ASD had scores below the screening cutoff points, indicating risk, most often on three ASQ domains: (a) communication, (b) gross motor, and (c) personal social. This exploratory study indicated the feasibility of using the ASQ in screening clinics for finding children at risk for ASD, if the ASQ is followed by specific ASD assessments. Design limitations, including a sample of children with ASD already receiving intervention services may explain the somewhat lower sensitivity of the SCQ.
Research on the Contribution of the Number of Patent Families to the Value of Patents——Taking Solar Energy as An Example

Field: Decision Sciences (Social Sciences)

[Purpose/significance] Research on the contribution of the number of patent families to the value of patents can provide an important reference for patents strategy layout optimization and patent value evaluation. [Methods/process] Taking the new clean solar energy field as an example, we identified high-value and low-value patent data sets, and designed experiments on patent family size differences between high-value patents and low-value patents. Finally, then SPSS 22 was used to verify the model. [Results/conclusion] Empirical research have shown that the contribution of the number of patent families to the value of patents is not invariable. With the continuous expansion of the patent families, the proportion of patent families is no longer significant difference between high-value patents and low-value patents. At this time, the increase in the number of patent families has significantly reduced the contribution to patent value.
A modelling analysis of pertussis transmission and vaccination in Rio de Janeiro, Brazil

Field: Medicine (Health Sciences)

Pertussis is an infectious respiratory disease for which mass vaccination is an effective preventive strategy. In many developed countries, where high vaccination coverage has been maintained for approximately 50 years, re-emergence of the disease has been observed in all age groups. In the municipality of Rio de Janeiro (RJ), where vaccination started in the 1980s, surveillance data show no sign of disease re-emergence. We developed a mathematical model that incorporates the major demographic aspects of a large urban centre in a developing nation, in addition to the most important epidemiological aspects of disease transmission. Parameter values were estimated based on RJ demographic and vaccine coverage data. Overall, all vaccination strategies determined a major decrease (over 95% decrease when compared to the pre-vaccine era) in the incidence of primary infections (occurring in individuals who have never been immunized through infection or vaccine). On the other hand, the strategies ( a ) three doses at age 2–11 months, ( b ) three doses plus booster at age 12–23 months, ( c ) three doses plus booster at age 4–5 years, and ( d ) three doses plus both boosters, differently affected the incidence of secondary infections (occurring in previously infected/vaccinated individuals). Given that the immunity against pertussis wanes with time and that the infectious agent has not been eliminated from the population, it is expected that pertussis will continue to be a problem in RJ. Actually, since immunity acquired from vaccine wanes faster than disease-acquired immunity and the possibility of natural boosters has decreased with mass vaccination, an increase in the incidence of secondary infections among older age groups is expected (and predicted by the model). Possible explanations as to why this dynamics is not captured by the RJ surveillance system are discussed. A poorly effective surveillance system and a lack of awareness regarding loss of immunity and the possibility of pertussis infection in older age groups are among them. Finally, we bring attention to the need of (i) field studies for the measurement of pertussis incidence in adolescents and adults; (ii) better understanding of the transmission dynamics currently occurring in RJ, and (iii) re-evaluation of vaccination strategies with the possible introduction of acellular vaccines for the vaccination of older individuals.
Forensic Mental Health in Corrections

Field: Social Sciences (Social Sciences)

This chapter reviews the distinctions between correctional and forensic mental health treatment, with emphasis on basic versus rehabilitative mental health services. Forensic and correctional interventions are both focused on persons who are criminal justice-involved; nevertheless, they involve different populations and aims. Correctional interventions are typically focused on facilitating change such that an offender is less likely to reoffend, and thus public safety is enhanced. Competency to stand trial (CST) is related to a defendant's current mental state and ability to participate in legal proceedings. Criminal responsibility is a legal issue focused on the defendant's state of mind at the time of the crime. Correctional scholars continue to strive to identify the most effective correctional philosophies for reducing suffering, institutional misconduct, crime, and criminal recidivism. Although recent statistics demonstrate that the rate of juvenile arrests has decreased since the early 2000s, efforts to reduce criminal activity among delinquent youth continue to be of vital importance within the juvenile justice system.
Diagnosis of mucin-producing tumor of the pancreas by balloon-catheter endoscopic retrograde pancreatography--compression study.

Field: Medicine (Health Sciences)

The procedure of choice for the treatment of mucin-producing pancreatic tumor (MPPT) remains controversial, since it includes not only malignant but also benign lesions. The purpose of the present study was to characterize 53 consecutive cases of MPPT and to elucidate the characteristics of benign or malignant MPPT according to the findings of an improved method of endoscopic retrograde pancreatography (ERP), namely balloon-catheter ERP-compression study (balloon ERP-CS), as well as endoscopic ultrasonography (EUS), in comparison with a histological examination. There were 37 male and 16 female cases with a median age of 63+/-11 (mean+/-SD). The balloon ERP-CS was performed in all cases, and the obtained pancreatograms were classified into two types: Main Duct type and Branch Duct type. The latter was further divided into subtypes A and B. The Branch Duct A type showed only cystic dilatation of the branch duct. If the main pancreatic duct downstream to a cyst showed more than a 5 mm dilatation, this was classified as a Branch Duct B type. Seventeen out of 19 Main duct types (89%) were histologically diagnosed as neoplasms including 13 lesions of cancer and 4 of adenoma. All the Branch Duct A type cases were diagnosed as hyperplasias. 23 Branch Duct B type cases contained 7 cancers, 8 adenomas, and 8 hyperplasias. In the Main Duct type, benign or malignant, the diagnostic ability of balloon ERP-CS was calculated as sensitivity 100%, specificity 40%, and accuracy 84%; in the Branch Duct type, sensitivity 73%, specificity 86%, and accuracy 82%. On EUS, it was found that the size of the tumor in the cyst, with respect to the maximum diameter as well as height, correlated well with the grade of malignancy. All tumors (n=35) greater than 20 mm in diameter were found to be cancerous. These findings indicate that the MPPT is highly suggestive of neoplasms when the dilatation of the main pancreatic duct is detected by balloon ERP-CS and when, in a case without dilatation of the main pancreatic duct, a nodular lesion greater than 10 mm in diameter is identified in the cyst by balloon ERP-CS as well as EUS. Our current patient management strategy for operations is as follows: Main Duct type patients and Branch Duct type patients with a nodular defect detected by balloon ERP-CS and with an elevation of more than 10 mm in EUS should have an operation. Other Branch Duct type patients without main pancreatic duct dilatation are followed up by balloon ERP-CS.
Weaning from mechanical ventilation: a cross-sectional study of reference values and the discriminative validity of aging

Field: Medicine (Health Sciences)

[Purpose] To evaluate pre-extubation variables and check the discriminative validity of age as well as its correlation with weaning failure in elderly patients. [Subjects and Methods] Two hundred thirty-nine consecutive patients (48% female) who were on mechanical ventilation and had undergone orotracheal intubation were divided into four subgroups according to their age: <59 years, 60-69 years, 70-79 years, and >80 years old. The expiratory volume (VE), respiratory frequency (f), tidal volume (VT), and respiratory frequency/tidal volume ratio (f/VT) were used to examine differences in weaning parameters between the four subgroups, and age was correlated with weaning failure. [Results] The rate of weaning failure was 27.8% in patients aged >80 years and 22.1% in patients aged <60 years old. Elderly patients presented higher f/VT and f values and lower VT values. The areas under the receiver operating characteristic curves for f/VT ratio were smaller than those published previously. [Conclusion] Our results indicate that aging influences weaning criteria without causing an increase in weaning failure.
98TiP Safety and efficacy of aumolertinib combined with anlotinib as 1st-line treatment in advanced lung cancer EGFR mutation with TP53 co-mutation

Field: Medicine (Health Sciences)

Aumolertinib has superior efficacy as the first-line standard treatment based on the AENEAS study, but its efficacy against concurrent mutations is still unclear, especially for the high incidence (up to 55%-65%) of TP53 co-mutation. In recent RELAY and ACTIVE studies, subgroup analysis has shown particular benefits for patients from the dual inhibition of EGFR and angiogenesis. Herein, we conduct a prospective study to examine aumolertinib plus anlotinib as a first-line treatment option for advanced NSCLC harbouring EGFR mutation with TP53 co-mutation. (NCT05778149). This is a phase II clinical study with a single-arm, exploratory design. 47 patients are scheduled to be enrolled. The key inclusion criteria are as follows:1) Locally advanced or metastatic NSCLC EGFR sensitive mutations (19del and L858R) and TP53 co-mutation; 2) Have not received systematic treatment; If the subject has received adjuvant therapy after completing radical treatment for early NSCLC and the subject has relapsed disease, ensure that the end of adjuvant therapy is more than 6 months from the first dose of the study and that various toxicities due to the adjuvant therapy have recovered; 3) ECOG 0-1, the expected survival is more than 6 months; 4)At least one assessable lesion (RECIST 1.1 ). Treatment regimen is aumolertinib 110mg p.o. QD daily and anlotinib 12mg p.o. QD for 2 weeks, three weeks a cycle, until disease progression or intolerable adverse reactions or death. The primary endpoint is progression free survival (PFS). Secondary endpoints include objective response rate (ORR), disease control rate (DCR), overall survival (OS) and safety. In addition, we also try to explore predictive or prognostic biomarkers (tissue and/or plasma) related to disease treatment response or drug resistance. Analyze the potential biomarkers in the biopsy tissue samples and blood samples after the disease progresses, and explore the possible mechanism of treating drug resistance. The first patient had been enrolled in February, 2022. NCT05778149. The authors. Jiangsu Hansoh Pharmaceutical Group Co., Ltd.
Researching Transnationalisation and Higher Education in the Context of Social Mechanisms

Field: Social Sciences (Social Sciences)

An increasing body of literature has begun to emerge in the context of transnationalisation, migration and higher education. This article contributes to the discussion by using a sociological lens to focus on the structure-agency link and, in particular, on the social mechanisms that explain how actors and structures interrelate and influence each other. Studies in higher education, migration and transnationalisation tend to focus on either structural or agential factors, whilst the social mechanisms linking both these factors are generally under-researched. This article aims to address this shortcoming by developing a conceptual framework for the study of both the structure-agency link and the social mechanisms that characterise transnationalisation and higher education. Theoretically, the framework is informed by Bunge's approach towards social mechanisms (M. Bunge, Emergence and Convergence: Qualitative Novelty and the Unity of Knowledge, University of Toronto Press, 2003; ‘How does it work? The search for explanatory mechanisms’, Philosophy of the Social Sciences, 2004, 34(2), 182–210) in combination with Pickel's notion of social mechanisms in psychosocial systems (A. Pickel, The Problem of Order in the Global Age: Systems and Mechanisms, Palgrave, 2006). The conceptual framework is illustrated through an explorative study of social mechanisms relating to transnational students' perceptions of and interactions with educational structures and systems in their home country and in England.
Proses Pemeriksaan Tindak Pidana Pemalsuan Surat Genose Pada Masa Pandemi Covid-19

Field: Social Sciences (Social Sciences)

Introduction: Forgery of letters is caused by unauthorized changes ( without valid permission ) to letter or documents.Threats to trevelers if they are found to have falsified a covid-19 free certificate with the aim of traveling in the midst of the covid-19 outbreak.Purposes of the Research: The purpose of the current study is to analyze and discuse how the process of forgery of letters during the covid-19 pandemic can be classified as a criminal act of forgery of letter, as regulated in article 263 of the criminal code. Methods of the Research: The research method in this study is a noemative research, using a law approach and a conceptual approach. research data sources include primary, secondary, tertiary legal sources. Data collection techniques in the from of literature study. Processing and analysis of legal material used in writing is using qualitative analysis methods.Results of the Research: The result of the research show that the criminal act of forging letters as referred to in article 236 of the criminal code, which was found on Thursday 27 May 2021, around 18:30 WIT at one of the Travel Agents PT. Laperissa Chaur on Ay Patty street, Ambon City. There were individuals who faked the GoNose covid-19 letter, the letter was made and assisted by suspect Rusrman, Husni Suatrean alias Nyong, Mahmudin alias Udin, and Rizky Nuralini Rizdianto alias Iki.
THE IDENTIFICATION OF BACILLUS BOTULINUS AND ITS TOXIN IN CULTURE AND IN CANNED FOODSTUFFS BY SEROLOGICAL METHODS

Field: Immunology and Microbiology (Life Sciences)

THE IDENTIFICATION OF BACILLUS BOTULINUS AND ITS TOXIN IN CULTURE AND IN CANNED FOODSTUFFS BY SEROLOGICAL METHODS R. A. Kelser CopyRight*From the Veterinary Laboratory Section, Army Medical School, Washington, D. C. https://doi.org/10.2105/AJPH.13.5.366 Published Online: August 30, 2011