jimnoneill/paper-to-field-training huggingface dataset:
Gynecomastia After Cytotoxic Therapy for Metastatic Testicular Cancer

Field: Medicine (Health Sciences)

No AccessJournal of UrologyOncology and Chemotherapy1 Oct 1982Gynecomastia After Cytotoxic Therapy for Metastatic Testicular Cancer A.R. Turner, D.W. Morrish, J. Berry, and R.N. Macdonald A.R. TurnerA.R. Turner More articles by this author , D.W. MorrishD.W. Morrish More articles by this author , J. BerryJ. Berry More articles by this author , and R.N. MacdonaldR.N. Macdonald More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)53247-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Gynecomastia After Cytotoxic Therapy for Metastatic Testicular Cancer." The Journal of Urology, 128(4), p. 879 © 1982 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 128Issue 4October 1982Page: 879 Advertisement Copyright & Permissions© 1982 by The American Urological Association Education and Research, Inc.MetricsAuthor Information A.R. Turner More articles by this author D.W. Morrish More articles by this author J. Berry More articles by this author R.N. Macdonald More articles by this author Expand All Advertisement PDF DownloadLoading ...
An angular frequency dependent filter for PET reconstruction

Field: Medicine (Health Sciences)

PET image quality is often limited by the presence of noise and blur. In this paper, we developed an angular frequency dependent filter for improving reconstruction of PET images. Our results indicated that the proposed filter outperforms the conventional method in terms of both visual quality and quantitative accuracy. In addition, the proposed filter can automatically adjust its degree of smoothing according to the count level of the input PET data.
Changes in the distribution of economic activity in Wrocław and its suburban area, 2008–2016

Field: Social Sciences (Social Sciences)

Abstract This article presents changes in the distribution of economic activity in Wrocław and its suburbs in the period 2008–2016. The study is based on the analysis of data from the REGON database. Additionally, the article presents the impact of migration of economic entities attributed to suburbanisation of economic entities on the changes noted in the distribution of economic entities in the Wrocław agglomeration. The article also presents the characteristics of migrating economic entities as part of the suburbanisation of economic entities in terms of numbers and types, as well as legal and capital status. Suburbanisation of economic entities was demonstrated to have a significant impact on the distribution of economic entities, both in Wrocław and in its suburban area, throughout the period of analysis.
On Some Accessory Minerals in Upper Paleozoic Granites of the Khrami Crystalline Massif

Field: Earth and Planetary Sciences (Physical Sciences)

The Khrami crystalline massif is exposed within the Black Sea – Central Transcaucasian terrane (Georgia). The massif is built up of Preсambrian gneiss-migmatite complex, the packet of Middle Paleozoic (?) metasandstones and protrusions of mantle serpentinites; Paleozoic gabbroids; Middle-Upper Paleozoic granitoids and rocks of volcanogenic-sedimentary complexes and Upper Paleozoic quartz-porphyry - granite-porphyry formations. A number of scientists have studied the granitoids of the Khrami crystalline massif, but detailed investigations on some minerals using modern analytical facilities have not been conducted yet. The Late Variscan granitoids of the Khrami massif are represented by biotite-hornblende-allanite-, biotite-microcline- and biotite-garnet-bearing granites and aliaskites. We have studied in detail the accessory minerals - garnet and allanite in the Late Variscan granites of the massif. Their microprobe analysis has been performed. According to the microprobe analysis of the studied garnets, the centre of the crystal is homogeneous, while the peripheral part is zonal. The amount of FeO decreases slightly from the centre to the periphery, while the amount of CaO and MgO significantly decreases; a well-expressed increase in MnO content is recorded. The variation in almandine content is insignificant. The amount of pyrope and grossular drops sharply from the centre to the periphery while the number of spessartine increases. The amount of Al2O3 in all varieties of granitoids is similar. In our opinion, the garnet formation occurred in two stages: during the crystallization process of granitic magma and its subsequent post-magmatic stage. The core of the garnet was formed in the magmatic stage, but its periphery - was in the cooling stage of granitic magma. According to the results of the microprobe study of allanite, the same - two stages of their formation have been conducted: during the crystallization process of granitic magma and in its next post-magmatic stage. The genesis of allanite in the biotite-hornblende-allanite-bearing granites of the massif is due to the concentration of REE in the granitic magma and the introduction of calcium by hydrothermal solutions. These allanites belong to the cerium variety with high content of Ce2O3, La2O3 and Nd2O3.
A clinical risk scoring system for the prediction of early infection after CAR-T therapy.

Field: Medicine (Health Sciences)

e23330 Background: CAR-T therapy has transformed the management of hematologic malignancies but is often complicated by severe infections, a leading cause of non-relapse mortality. Fever within the first 30 days post-infusion frequently results from either cytokine release syndrome (CRS) or infection, necessitating prompt differentiation and timely clinical intervention. Methods: In this study, we characterized early fever and infection events (days 0-30 after CAR-T infusion), found independent predictors and formulated a risk scoring system of infection in 535 patients undergoing CAR-T therapy from center No. 1 (internal cohort). Then we validated the risk scoring system in an external validation cohort (31 patients) from other research centers and a prospective validation cohort (31 patients) from center No.1. Results: A total of 503 fever episodes were documented among 443 patients in the internal cohort. Most patients (88%) experienced only a single fever episode, with 20% of these initial episodes attributed to infection and 80% to CRS. However, for subsequent fever episodes, infections became predominant, accounting for 82% to 100% of cases. Fever patterns in the external and prospective cohorts were consistent with findings from the internal cohort. Since first fever episodes often overlap with CRS, we utilized significance analysis and logistic regression to analyze infection characteristics, ultimately identifying six routine clinical indicators-neutropenia grades, lymphocyte counts, CRP levels, IL-6 levels, platelet counts, and changes in ferritin levels-as key predictors for constructing a predictive model. The sensitivity across different cohorts ranged from 79% to 100%, while the specificity ranged from 76% to 83%. Based on different levels of infection risk, we stratified the risk of fever events according to the likelihood of infection in predictive model and provided tailored anti-infection recommendations. The risk score has been incorporated into an online calculator accessible to the public (http://tongji.dcykjmb.com/). Conclusions: In this study, we developed a universal risk score system of infection based on patient characteristics at the onset of fever within 30 days following CAR-T infusion, aiming to rapidly provide the recommends for the clinical to treatment the fever during CAR-T therapy.
Be Happy: The Role of Resilience Between Characteristic Affect and Symptoms of Depression

Field: Psychology (Social Sciences)

Characteristic affect may influence the development of resilience. Higher levels of resilience may in turn decrease the likelihood of individuals developing symptoms of depression. All first year psychology students (N = 217) were recruited in this longitudinal study to examine whether resilience mediates the relationship between characteristic affect and symptoms of depression. One hundred and seven students completed survey measures at the start of a semester and again 3 months later. Results indicated that greater negative affect predicted worsening of depressive symptoms over 3 months, while greater positive affect predicted a lessening of depressive symptoms over 3 months. Resilience fully mediated the effects of positive affect on change in depression and partly mediated the effects of negative affect on change in depression. These results are interpreted in the context of a hierarchical model of affect and the Broaden and Build Theory, which may explain how resilience arises from positive affect and mediates between affect and symptoms of depression over time.
Radiation effects of wearable antenna on human tissues

Field: Engineering (Physical Sciences)

Nowadays human life is comprehensively surrounded by many number of wireless devices and gadgets. Modern generation lives and works in wireless application devices such as mobile phones, remote control, GPS tracking devices that makes our living more comfortable and accessible. It directly infers that we are continuously in contact with electromagnetic fields. It is very essential to study the effects of electromagnetic fields on human body, only to understand the possible health effects that these electromagnetic fields can cause on human body. In this project, four layers of the human tissue i.e., skin, fat, muscle and bone were also designed with all their required parameters embedded into it. The multilayer human tissue model is exposed for exemplary frequencies from 0.4 GHz to 3 GHz. The multilayer human tissue model was designed and verified in the Computer Simulation Technology (CST) using the Microwave and Bio Medical Device-Magnetic Resonance Imaging (MRI). This project focuses on studying the radiation effects in human tissues on exposure to electromagnetic fields emitted from one particular antenna. The antenna designed is a dual band antenna embedded within a wrist wearable Personal Locator Device (PLD). It is capable of transmitting distress signals alerts (Beacons) and receives GPS signals simultaneously. The simulation is performed and analysed for different human body parts such as arm in specific. The arm is chosen since the antenna is worn on the wrist part of the arm. The antenna has been designed and reproduced using the Computer Simulation Technology (CST) and the simulations are run to study the radiation effects. To check and determine whether the antenna could be safe or not, Specific Absorption Rate (SAR) and temperature increase have been calculated and tabulated for different human tissues.
Pengaruh Komposisi Media Tanam dan Konsentrasi Pupuk Organik Cair Daun Kelor (moringa oleifera L.) terhadap Pertumbuhan dan Hasil Tanaman Bawang Merah (Allium ascalonicum L.)

Field: Agricultural and Biological Sciences (Life Sciences)

This study aims to determine the effect of the composition of the planting medium with the concentration of liquid organic fertilizer of Moringa leaves on the growth and yield of shallot plants. This research was conducted in October 2022 - March 2023 in the greenhouse of the Soil Science Study Program, Faculty of Agriculture, University of Jember. The study used a completely randomized design with 2 factors, there were 16 treatment combinations, 3 repetitions, and each repetition there were 3 experimental units, so that 144 experimental units were obtained. The first factor is the composition of the planting medium consisting of control; soil: cow manure (1:2); soil: cow manure (2:2) and soil: cow manure (3:2). The second factor was the concentration of liquid organic fertilizer for moringa leaves which consisted of control; 20ml/l; 50 ml/l and 80ml/l. The results showed that there was an interaction effect between the treatment of the composition of the planting medium and the concentration of liquid organic fertilizer of Moringa leaves on the fresh weight of the tubers and the dry weight of the tubers. The treatment of the composition of the planting media was able to increase the growth and yield of shallot plants, and the addition of liquid organic fertilizer for Moringa leaves was able to increase the growth and yield of shallot plants.
Stress management for breast cancer patients: service development

Field: Health Professions (Health Sciences)

There is broad consensus that following cancer diagnosis, patients’ lives can be disrupted by diffuse, long-term psychosocial problems. There is also increasing evidence to suggest that group cognitive behavioural techniques, as used in stress management and relaxation may be an effective means of offering help. In the context of increasing interest in psychological interventions for patients suffering from cancer, this article discusses the rationale for a stress management programme, incorporating relaxation techniques, for women with breast cancer. The content and implementation of the programme are described and psychological approaches including stress management and relaxation techniques for the wellbeing of patients in cancer care are outlined.
Calf flow reserve with H(2)(15)O PET as a quantifiable index of lower extremity flow.

Field: Medicine (Health Sciences)

As expected, FR was significantly lower in PAD subjects compared with healthy subjects as assessed with TD and PET but not with PL. PET-derived FR appears to be reproducible and generates sharper and higher indices of recruitable flow in healthy subjects and PAD. These findings have implications for the use of PET-derived FR as a sensitive index of recruitable flow in angiogenesis trials.
IDDF2018-ABS-0109 SOFOSBUVIR/VELPATASVIR for 12 weeks in genotype 1–4 hcv-infected liver transplant recipients

Field: Medicine (Health Sciences)

Background

Treatment with SOF/VEL for 12 weeks results in high sustained virologic response rates 12 weeks after treatment (SVR12) in genotype 1–6 HCV infected patients in clinical trials and real-world settings. The current study evaluated the safety and efficacy of SOF/VEL in adult patients with recurrent chronic genotype (GT) 1–6 HCV infection post-liver transplant.

Methods

This Phase 2, single-arm, open-label study evaluated 12 weeks of SOF/VEL 400/100 mg daily for 12 weeks in HCV-infected liver transplant recipients. Patients could be treatment experienced or treatment naive with no cirrhosis or compensated cirrhosis and had to be ≥3 months post-transplant with no signs of rejection at screening and history of pre-transplant chronic HCV. The primary endpoint was SVR12.

Results

A total of 79 patients were enrolled and treated. Of these, 81% were male, 82% were white, 9% had compensated cirrhosis, 59% were treatment-experienced, 47% had GT1, 4% GT2, 44% GT3, and 5% GT4 HCV infections. For immunosuppression, 71% of patients used tacrolimus, 24% mycophenolic acid, 14% cyclosporine, 11% azathioprine, 10% sirolimus, 6% everolimus, and 1% prednisolone. Median (range) time from liver transplantation was 7.5 (0.3–23.9) years. Rates of SVR4 for available patients are presented in the Table (IDDF2018-ABS-0109 Table 1). There was one virologic failure (relapse; GT1a, non-cirrhotic, treatment naive) and one non-virologic failure (GT1b, cirrhotic, treatment naive). All 34 GT3 HCV-infected patients including 2 with cirrhosis achieved SVR4. Complete SVR12 and viral sequencing data will be presented. There were 61 (77%) patients with adverse events (AEs). Common (>10%) AEs were headache (24%), fatigue (20%), and cough (10%). One patient discontinued SOF/VEL on Day 7 due to an AE of grade 1 hyperglycemia. No serious or severe AEs were assessed by the investigator as related to SOF/VEL, there were no episodes of liver transplant rejection, and there were no deaths.

Conclusions

Treatment with the single tablet regimen of SOF/VEL for 12 weeks was highly effective and well tolerated in genotype 1–4 HCV-infected liver transplant recipients with and without cirrhosis.
Habitat Assessment of Bocachico (Prochilodus magdalenae) in Ciénaga de Betancí, Colombia, Using a Habitat Suitability Index Model

Field: Environmental Science (Physical Sciences)

This study evaluates the habitat of the Bocachico fish (Prochilodus magdalenae) in the Ciénaga de Betancí, Colombia, using a habitat suitability index (HSI) model. Wetlands like the Ciénaga de Betancí are under significant pressure from anthropogenic activities, affecting biodiversity and ecosystem health. The Bocachico, a species of immense cultural and economic importance, faces habitat degradation and fragmentation. Using hydrodynamic and water quality data, a numerical model (EFDC+ Explorer 11.5), and field data collected from multiple sampling campaigns, we assessed habitat suitability based on five key parameters: water temperature, dissolved oxygen, ammonia nitrogen, velocity, and depth. The model results indicated that environmental conditions in the wetland remained relatively stable during the dry season, with an average HSI score of 0.67, where 9% of the wetland area displayed acceptable conditions, and the remaining 91% displayed medium conditions. The wet season, on the other hand, had an average HSI score of 0.64, with 7.2% of the area in the acceptable suitability range, and the remaining 92.8% in the medium category. Variations in HSI were primarily driven by ammonia nitrogen levels, water velocity, and depth. Despite limited fluctuations in the HSI, areas of low suitability were identified, particularly in regions impacted by human activities. These findings have practical implications for conservation strategies, providing valuable insights for the sustainable management and conservation of the Ciénaga de Betancí, informing strategies for improving habitat conditions for the Bocachico, and supporting wetland restoration efforts.
Reye Syndrome and Aspirin Therapy

Field: Medicine (Health Sciences)

Sir.—A significant number of children require long-term aspirin therapy for collagen vascular disorders, rheumatic fever, and other inflammatory diseases. Several cases of Reye syndrome (RS) have recently been documented in these children, who may actually be at an increased risk to develop the syndrome.1Although reports indicate a decline in the incidence of acute rheumatic fever (ARF),2a recent dramatic resurgence of ARF has occurred in Utah. This resurgence is reflected in the increased number of ARF admitted to Primary Children's Hospital, Salt Lake City, in 1985: Average No. Period of Cases 1960-1964 24.6 1965-1969 18.0 1970-1974 14.2 1975-1979 5.0 1980-1984 7.6 1985 50 (Actual No.) We describe herein a child who developed RS while being treated with salicylates for ARF. Patient Report.—A 7-year-old girl was admitted to the University of Utah Medical Center, Salt Lake City, for altered mental status. Three weeks prior to admission,
Real-Time Observations of Interfacial Lithiation in a Metal Silicide Thin Film

Field: Materials Science (Physical Sciences)

Interfacial reactions and phase transformations play a significant role in the capacity and reversibility of lithium batteries. Understanding interfacial structural changes is especially important in alloying or conversion reactions found in higher-capacity intermetallic or metal oxyfluoride systems. Using in-situ X-ray reflectivity, we observe the lithiation of a stratified chromium silicide film with sub-nanometer resolution as a model system for characterizing such lithiation mechanisms. In-situ X-ray reflectivity of the thin film reveals that the sample lithiates to form the 1 nm thick low-electron-density regions at the buried interfaces separating each phase at sufficiently low electrochemical potentials. The reflectivity also indicates a significant accumulation of lithium at the surface at potentials approaching 0 V vs Li/Li+. The lithiation on the surface is fully reversible, whereas that in the film is partially irreversible. The observed mechanism for interfacial lithiation is likely a general feature of intermetallic electrodes and could be optimized for higher surface area nanostructures.
Drivers of Infectious Disease Outbreaks: How Climate, Environment and Disease Control Programs Influence Occurence of Infectious Disease Outbreaks

Field: Medicine (Health Sciences)

This research study described the factors driving infectious disease outbreaks using Foot-and-mouth disease (FMD) in Uganda and Lyme disease in North Dakota (ND), Minnesota (MN) and Wisconsin (WI) as case studies. Retrospective data on FMD vaccines and outbreaks in Uganda (2001 ? 2010) and Lyme disease in ND, MN and WI (1990 ? 2011) was used. The time (7.5 weeks) taken to respond to FMD outbreaks, limited serotyping/subtyping (9/121) of outbreaks and the low percentage of cattle vaccinated (2.1 ? 21.2%) portray ineffective control programs. Similarly, increase in fall temperature (P = 0.0189) and annual precipitation (P = 0.0250) were associated with increased human Lyme cases. Shrub land coverage and human population also increased in WI, MN and ND while forest coverage increased in ND. These favor tick and deer proliferation leading to increased human exposure to Lyme Borreliosis. Therefore ineffective disease control programs, climate and environment factors influence infectious disease occurrence.
Accepting Failure: Availability through Repair-centric System Design

Field: Computer Science (Physical Sciences)

Motivated by the lack of rapid improvement in the availability of Internet server systems, we introduce a new philosophy for designing highly-available systems that better reflects the realities of the Internet service environment. Our approach, denoted repair-centric system design, is based on the belief that failures are inevitable in complex, human-administered systems, and thus we focus on detecting and repairing failures quickly and effectively, rather than just trying to avoid them. Our proposal is unique in that it tackles the human aspects of availability along with the traditional system aspects. We enumerate a set of design techniques for building repair-centric systems, outline a plan for implementing these techniques in an existing cluster email service application, and describe how we intend to quantitatively evaluate the availability gains achieved by repair-centric design.
Ship waves in rotating plasma in tokamaks

Field: Physics and Astronomy (Physical Sciences)

Plasma rotation can lead to excitation of waves in the plasma by perturbations that have zero frequency in the laboratory frame. Drift waves have minimum velocity threshold for excitation. Potential drift waves with kρi≤0.1 (k is the wave number, ρi is the ion cyclotron radius) excited at the edge and propagating toward the plasma interior are used to explain some nonlocal properties of plasma transport observed experimentally in transitions from the low (L) to high (H) confinement regime (L–H transitions).