jimnoneill/paper-to-field-training huggingface dataset:
Structural and Immunogenic Properties of a Major Antigenic Determinant in Neutral Salt‐Extracted Rat‐Skin Collagen

Field: Immunology and Microbiology (Life Sciences)

The major antigenic determinant of neutral salt‐extracted rat‐skin collagen is located in the C‐terminal CNBr peptide α1‐CB6 b of the α1‐chain. This peptide is shortened by 20 amino acid residues from its C‐terminal nonhelical end if compared with α1‐CB6 obtained from collagen α1‐chains extracted under denaturating conditions. As reported earlier, degradation by tissue proteases during extraction was assumed as the main reason for the observed reduction in size. The C‐terminal sequence of α1‐CB6 b was determined as Tyr‐Asp and was found to be essential for antigenic activity. Proportional loss of binding to antibodies with decrease in size was observed for appropriate proteolytic fragments derived from α1‐CB6 b . Since this peptide extends only five amino acid residues beyond the helical collagen sequence, an important contribution of the conformational structure for this antigenic determinant is suggested. Decrease in ability to induce high antibody titers to α1‐CB6 b was already observed at a higher structural level, e.g. after denaturation of triple‐helical collagen to random‐coiled α‐chains. The same result could be obtained if adjuvant was omitted in the priming injection.
Three-Dimensional Angiogenic Evaluation of the Effect of Mifepristone in Early Gestation: Pilot Study

Field: Medicine (Health Sciences)

Mifepristone (RU486) it is known as an effective abortifacient and postcoital contraceptive method, whose mechanism is not yet known. We carried on a pilot study with the aim of determining the effect that Mifepristone could have in utero-placental vascular compartment during the first trimester of pregnancy compared with placebo. This is a randomized, double-blind, placebo-controlled research. We randomly assigned to two groups patients requesting pregnancy termination with a gestational age between 9th and 11st weeks: Group A receiving placebo and Group B receiving RU. With transvaginal ultrasound tridimensional probe we measured at an initial time (t1) and then 4 hours after administration of Mifepristone or placebo (t2) Doppler parameters: uterine arteries mean Resistance Index, spiral arteries Resistance Index, intervillous flow, umbilical Resistance Index and tridimensional vascular settings and the placental volume. We observed how Mifepristone shows an immediate selective hemodynamic effect in trophoblastic tissue in the first hours of administration. A significant decrease in spiral arteries pulsatility index was demonstrated, without modifying uterine maternal and fetal territories or the other studied parameters. Angiopower 3D evaluation of the interface maternal fetal is complex and encourages to carry further investigations carry further investigations.
Draft Genome Sequence of Escherichia coli E1728 Isolated from Marine Sediment in Hong Kong

Field: Immunology and Microbiology (Life Sciences)

ABSTRACT Recent findings of Escherichia coli persisting autochthonously in environmental matrices outside animal bodies have revealed largely unknown facets of the lifestyle and ecophysiology of the species that have yet to be explored. Here, we report the draft genome sequence of E. coli E1728 isolated from marine sediment.
The Cultural Indigenization of a Soviet “Red Classic” Hero

Field: Arts and Humanities (Social Sciences)

This chapter traces the reception of Nicholas Ostrovskii’s socialist-realist classic How the Steel was Tempered (Kak zakalialas’ stal,’ 1934) in China, from its first appearance in the late 1930s through the ideology-driven first decades of the People’s Republic of China (PRC) until the present. This chapter further explores the many roles attributed to the novel’s protagonist Pavel Korchagin, from war-hero and popular icon of the Mao era to unlikely role model during the reform period and, finally, symbol of nostalgia in post-socialist China. By illustrating how the novel has been thoroughly indigenized and become inseparable both from China’s revolutionary history as well as its popular culture, this chapter comments on the discursive complexity of this unlikely Red Classic and its afterlife in China.
Effect of maternal iron deficiency anemia on fetal hemodynamics and pregnancy outcome

Field: Medicine (Health Sciences)

Background: In pregnancy, anaemia has detrimental impacts on maternal and fetal health.During pregnancy, chronic anemia may trigger glositis, stomatitis, alterations in the nails and skin, shortness of breath and heart failure in the mother.Obstetrical complications are also known, such as low birth weight babies, IUGR, elevated preterm delivery rate, and elevated perinatal deaths.Postpartum hemorrhage also aggravates the condition. Aim of the work:To evaluate the impact on fetal hemodynamics of maternal iron deficiency anemia by Doppler parameters of umbilical and MCA, C/U ratio and to evaluate short term neonatal outcome by Apgar score and birth weight.Patients and Methods: This cross sectional cohort study included 300 pregnant women suitable candidates who attended Al-Hussein and Sayed Galal Hospital for delivery and casualty department in the period between December 2019 October 2020.Results: Our results showed that oral and parenteral iron were superior than blood transfusion as regards the clinical and sonographic outcome (IUGR, preterm labor, NBW, APGAR score and Doppler indices) with a more rapid improvement using parenteral iron.However, those patients who received blood transfusion (group C) had a better elevation in hemoglobin levels compared to oral and parenteral iron.Conclusion: Patients who received blood transfusion (group C) had a better elevation in hemoglobin levels however Patients who received oral and parenteral iron were superior than blood transfusion as regards the clinical and sonographic outcome .
Effect of Yiqi Yangyin Huoxue recipe against diabetic extremital gangrene in rats

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Objective:To study the effect of Yiqi Yangyin Huoxue(YQYYHX)recipe against diabetic extremital gangrene (DEG) in rats.Methods:In order to establish rat model with DEG,male Wistar rats were injected with moderate dose of steptozotocin (STZ),and then the room temperature was down regulated appropriately.Diabetes mellitus (DM) rats were randomly divided into two groups:DM treated group and DM control group,then the DM treated group was treated with YQYYHX recipe.At the same time,each group's fasting plasma glucose (FPG),triglyceride (TG),total cholesterol (TCh) and fasting insulin (FINS) level were measured before and after the animal models were established.After experiment,SOD,NOS,NO and MDA in pancreatic islet were measured,and the index of β-cell's function in HOMA (HBCI) was also calculated,in addition,each group's body weight (BW),water drinking amount (WDA) and syndrome of DEG were measured.Results:At the beginning of the experiment,compared with normal group,FPG,TG,TCh and WDA in DM group increased significantly (P0.05),while BW,FINS level and HBCI remarkably decreased (P0.05).At the end of the experiment,compared with the control group,FPG,TG,TCh,NO,NOS,MDA and WDA in the DM treated group significantly lowered (P0.05),while BW,FINS level,SOD and HBCI remarkably increased (P0.05),syndrome of DEG significantly mitigated too (P0.05).Conclusion:YQYYHX recipe can improve the β-cell's function of diabetic rats,increase FINS and HBCI,decrease FPG,TG,TCh,and be effective in treating diabetic rats with DEG.
Assessment of BV & the more common anomalies of binocular vision

Field: Medicine (Health Sciences)

Abstract Purpose Binocular vision is the co‐ordination and integration of what is received from the two eyes separately into a single binocular percept. Simultaneous macular perception is the most elementary type of binocularity and represents simple sensory fusion. It occurs when the visual cortex processes separate stimuli from the two eyes at the same time and perceives them as a single image. However, true fusion occurs when both two images are fused, and some effort is made to maintain this fusion by adding a motor response. Finally these fused images of the two eyes are blended to produce a stereoscopic effect. Thus stereopsis involves a perceptual synthesis at a higher level. Methods When investigating binocular vision we should aim at assessing the presence or absence of 1) simultaneous perception, 2) fusion with some amplitude and 3) stereopsis. Results Here we examine the mechanisms of these conditions and how they reflect increasing levels of binocularity. Additionally, we will discuss the different clinical tests available to assess these conditions and what is observed when abnormal binocular vision is present. Conclusion Understanding binocular vision and how there are different levels of processing is of great importance. This talk will try to assist on the understanding of the mechanisms of binocular vision and stereopsis so we can be in better position to understand the clinical findings of our patients and what they mean in terms of cortical processing.
Effects of Diets Containing Ammoniated Beef on Markers of Ammonia Metabolism in Livers From Diet-Induced Obese Mice

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Objectives: Diets high in fat, sugar and sodium and low in fruits and vegetables, especially leafy greens, tend to have an acidic pH, which may partly contribute to metabolic dysregulations including acidosis. We have previously reported physiological improvements from pH-enhanced beef with ammonium hydroxide, but the underlying mechanisms remain unknown. Therefore, we hypothesized that these metabolic ameliorations, in obese mice consuming diets containing ammoniated beef, compared to non-ammoniated beef, are mediated by changes in hepatic ammonia metabolism. Methods: Male and female B6 mice were fed 4 diets for 12 weeks: Low Fat Beef, High Fat Beef, without (LFB or HFB, respectively) or with ammoniation (LFBN and HFBN). Mice were metabolically phenotyped and fecal samples collected during the interventions. Tissues including liver and cecal samples were collected after the intervention and stored for further analyses. Using qPCR, expression of genes involved in ammonia metabolism were determined, and included markers of the urea cycle (Arg1, Asl, Ass1, Cps, Ornt1, Otc, Nags), ammonia transport (Rhbg), bicarbonate synthesis (Ca5a), polyamine synthesis (Odc), and glutamine synthesis (Gs). Results: Histological analysis of male liver triglyceride content via AdipoGuage software revealed high-fat diets increased liver TG accumulation [P< 0.0001], with no significant effects from ammonia. In female livers, HF decreased mRNA levels of both Ass1 [P=0.0005] and Ornt1 [P=0.0049]; while in males only Ornt1 mRNA levels were decreased by HF [P=0.0043]. Moreover, ammoniation led to trends of increased expression of Asl [P=0.0544] and Ass1 [P=0.0716] in females. Also, ammoniation increased Ca5a mRNA levels in females [P=0.0022]. By contrast, limited changes were observed in male liver. Conclusions: Our results indicate that both ammoniation and fat content sex-dependently regulate hepatic urea cycle metabolism at the mRNA levels. Experiments are ongoing to measure these changes at the protein level, as well as in other target ammonia metabolizing tissues such as the kidneys. This research will help enhance our understanding of the effects of dietary pH, fat content, and sex in metabolic diseases, and warrants further translational research in this area. Funding Sources: Funded by Empirical Foods Inc.
Production of protein feed from a mixture of lees fermented by multi-strains

Field: Agricultural and Biological Sciences (Life Sciences)

Using mixed strains of Aspergillus oryza and yeast,the influence of medium composition and fermentation condition on the production of feedstuff from a mixture of lees was investigated.It was found that the optimum medium composition was beers lees : rice wine lees: bean flour: wheat bran = 4:1:1:4,dry mass : water = 1:1.8,(NH4)2SO4 2%,KH2PO4 1%,inoculation time of Aspergillus oryza at 16 h,and fermentation time 68 h.Under this condition,in the medium with mixed strains,the yeast concentration was three times higher than that by single strain fermentation,and the crude protein(enhanced to 35.74%) was 9.5% higher than that of the original medium.Moreover,the feedstuff obtained from the fermentation with the mixed strains contained protease and cellulases with activity of 901 U/g and 1824 U/g(dry mass),respectively.
"Computed Tomography Perihematomal Rims": A Perihematomal Low-Density Area Is a Part of an Acute Brain Hemorrhage

Field: Medicine (Health Sciences)

Objective Computed tomography (CT) can be used for visualizing acute intracerebral hemorrhages (ICHs) as distinct hyperdense areas and cerebral edema as perihematomal low-density areas (LDAs). We observed a perihematomal LDA on CT, which appeared to be part of a hemorrhage on magnetic resonance imaging (MRI) in acute ICH. We named this "CT perihematomal rim" and evaluated its characteristics and clinical significance. Methods We stratified patients with acute ICH according to the presence or absence of a CT perihematomal rim and then compared their radiologic findings. Logistic regression analyses were performed to assess whether the CT findings can predict the presence of a CT perihematomal rim. Patients Patients within 24 hours of ICH onset who were admitted between September 1, 2014, and October 31, 2018, were registered. Results Overall, 139 patients (91 men; mean age, 66 years) were investigated. CT perihematomal rims were observed in 40 patients (29%). ICH volumes on CT were 30% smaller than those on MRI in patients with CT perihematomal rims. On a multivariate analysis, the presence of a CT perihematomal rim was independently associated with the maximum diameter of the perihematomal LDA. According to a receiver operating characteristic analysis, the maximum LDA diameter threshold was 7.5 mm (sensitivity, 85%; specificity, 83%). Conclusion CT perihematomal rims were observed in 29% of the patients with acute ICH. A perihematomal LDA (>7.5 mm) in acute ICH cases should be considered a CT perihematomal rim. Clinicians should be aware that the ICH volume on CT may be underestimated by 30%.
Controlling TDI Hazards

Field: Chemical Engineering (Physical Sciences)

RETURN TO ISSUEPREVNewsNEXTControlling TDI HazardsAnalytical monitoring technique ensures nontoxic isocyanate level in plant and laboratory atmosphereCite this: Chem. Eng. News 1956, 34, 40, 4826Publication Date (Print):October 1, 1956Publication History Published online5 November 2010Published inissue 1 October 1956https://doi.org/10.1021/cen-v034n040.p4826Copyright © 1956 AMERICAN CHEMICAL SOCIETYArticle Views4Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (105 KB) SUBJECTS:Atmospheric chemistry,Foams,Hydrolysis,Plastics Get e-Alerts
Codes, Ciphers, and Cryptography—An Honors Colloquium

Field: Mathematics (Physical Sciences)

Abstract At the suggestion of a colleague, I read The Code Book, [32 Singh, S. 1999. The Code Book: The Science of Secrecy from Ancient Egypt to Quantum Cryptography, New York: Anchor Books, Random House, Inc. [Google Scholar]], by Simon Singh to get a basic introduction to the RSA encryption scheme. Inspired by Singh's book, I designed a Ball State University Honors Colloquium in Mathematics for both majors and non-majors, with material coming from The Code Book and many other sources. This course became so popular that we had to open up more than one section, due to the large number of requests! This article looks at the challenges of designing a cryptography course “from scratch,” outlines the topics chosen, and gives examples of homework and discussion questions used.
Immunological traits have the potential to improve selection of pigs for resistance to clinical and subclinical disease

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract It was reasoned that, if we used a large sample of pigs, we could demonstrate that total and differential numbers of leukocytes, expression levels of swine leukocyte antigens (SLA) I and II, and serum concentrations of IgG and haptoglobin show additive genetic variation and are, therefore, potentially useful as criteria to improve selection of pigs for resistance to clinical and subclinical disease. We tested this premise by assessing 4204 male pigs from the Duroc, Landrace, and Yorkshire breeds for total and differential numbers of leukocytes and serum concentrations of IgG and haptoglobin; 1217 of the Duroc and Landrace pigs were also assessed for expression levels of SLA I and II. We estimated the amount of additive genetic variation by fitting linear animal models to the total and differential numbers of leukocytes and serum concentrations of IgG and haptoglobin. We fitted linear sire models to the expression levels of SLA I and II. We detected additive genetic variation for each group of traits. Total and differential numbers of leukocytes were moderately heritable ( h 2 =0·22 to 0·30), expression levels of SLA I and II were moderate-to-highly heritable ( h 2 =0·46 to 1·23), while serum concentrations of IgG and haptoglobin were lowly heritable ( h 2 =0·14 to 0·16). The additive genetic variation shown for the immunological traits is encouraging for pig breeders. It indicates that these traits are potentially useful as criteria to improve selection of pigs for resistance to clinical and subclinical disease.
GreyNet Quarterly Newsletter Volume 16, Issue 1, 2024

Field: Arts and Humanities (Social Sciences)

CONTENTS: ▪ TGJ’s Editorial Board celebrates its 20th Year, 2005-2024 ▪ GreyNet’s Silver Anniversary Conference celebrated in Amsterdam ▪ Prof. Steenhoven’s Keynote Address on Climate Change and Grey Literature ▪ Open Access to the GL25 Conference Program Book and Proceedings ▪ GreyNet Award Speech 2023 honoring Dr. SeokJong Lim, KISTI ▪ GreyNet International Associate Membership 2024 now open ▪ The PUBGREY Project and the Case of Climate Change ▪ Seminar – A New Approach to the Field of Grey Literature 2024.
Cyberspace and Cybersecurity: Problems, Perspectives, Technologies

Field: Computer Science (Physical Sciences)

The purpose of the article is to study and consider the general problems of such an important area of information activity of the state, business, education, science as cyber security. The research methods are the methods of semantic analysis of the basic concepts of the considered domain (cybersecurity). The article is dedicated to the approaches to the interpretation of the concepts of cyberspace and cyber security, related to both organizational and technical aspects. The article considers the essence of cyberspace and cyber security from the standpoint of state support of this area of information activity. The article discusses the main problems of cyber security and their solutions. It is indicated that computer viruses are one of the aspects of cyber threats. Their types and main ways of their elimination and neutralization are considered. The novelty of the study is the proposed ways to ensure the cybersecurity of the information space of enterprises and computer networks (including the Internet). The main conclusion of the research carried out in the article is that informatization and digitalization nowadays penetrate all spheres of activity in the state, society, business, science, education, and the individual. Therefore, the search for ways to ensure cybersecurity (in particular, the development of appropriate technologies) has become an important aspect of the IT sector.
Analysis of One-Bit Quantized Linear Precoding Schemes in Multi-Cell Massive MIMO Downlink

Field: Computer Science (Physical Sciences)

This work studies a multi-cell one-bit massive multiple-input multiple-output (MIMO) system that employs one-bit analog-to-digital converters (ADCs) and digital-to-analog converters (DACs) at each base station (BS). We utilize Bussgang decomposition to derive downlink signal-to-quantization-plus-interference-plus-noise ratio (SQINR) and ergodic achievable rate expressions under one-bit quantized maximum ratio transmission (MRT) and zero-forcing (ZF) precoding schemes considering scenarios with and without pilot contamination (PC) in the derived channel estimates. The results are also simplified for the mixed architecture that employs full resolution (FR) ADCs and one-bit DACs, and the conventional architecture that employs FR ADCs and DACs. The SQINR is shown to decrease by a factor of $2/π$ and $4/π^2$ in the one-bit setting compared to that achieved in the mixed setting and conventional setting respectively under MRT precoding without PC. Interestingly, the decrease in SQINR is less when we consider PC, which is shown to adversely impact the conventional system more than the one-bit system. Similar insights are obtained under ZF precoding with the decrease in the SQINR with the use of one-bit ADCs and DACs being more pronounced. We utilize the derived expressions to yield performance insights related to power efficiency, the numbers of antennas needed by the three architectures to achieve the same sum-rate, and energy efficiency.
Medical devices; clinical chemistry and clinical toxicology devices; classification of newborn screening test systems for amino acids, free carnitine, and acylcarnitines using tandem mass spectrometry. Final rule.

Field: Medicine (Health Sciences)

The Food and Drug Administration (FDA) is classifying newborn screening test systems for amino acids, free carnitine, and acylcarnitines using tandem mass spectrometry into class II (special controls). The special control that will apply to the device is the guidance document entitled "Class II Special Controls Guidance Document: Newborn Screening Test Systems for Amino Acids, Free Carnitine, and Acylcarnitines Using Tandem Mass Spectrometry." The agency is taking this action in response to a petition submitted under the Federal Food, Drug, and Cosmetic Act (the act) as amended by the Medical Device Amendments of 1976, the Safe Medical Devices Act of 1990, the Food and Drug Administration Modernization Act of 1997, and the Medical Device User Fee and Modernization Act of 2002. The agency is classifying the device into class II (special controls) in order to provide a reasonable assurance of safety and effectiveness of the device. Elsewhere in this issue of the Federal Register, FDA is publishing a notice of availability of a guidance document that is the special control for this device.