jimnoneill/paper-to-field-training huggingface dataset:
IMPACT OF MAIZE RESEARCH AND EXTENSION IN BANGLADESH

Field: Agricultural and Biological Sciences (Life Sciences)

The study was undertaken during 2001-02 to evaluate the past investment on research and extension of maize in Bangladesh. For the purpose, Economic Surplus Model with ex-post analysis was used to estimate the returns to investment on composite varieties and hybrids of maize that have replaced the local varieties. The growth rate of area, production and yield of maize were increased dramatically after the release of maize varieties. The internal rate of return (IRR) to investment was calculated at 23%. During 2000-01, about 65.70% more maize production was made available because of the farmers' adoption of composite varieties and hybrids of maize. The yield of composite varieties of maize ranged from 40 to 65% and hybrids ranged from 73 to 79% higher over the local varieties. Under various assumptions about the research and extension expenditures, the IRR ranged from 17 to 28% and benefit cost ratio from 9 to 19. The accumulated foreign exchange saving since 1992-93 was Tk 291.59 billion. The study indicates that the funding of maize research and extension is a good investment. Therefore, both government and donor agencies should come forward to invest in maize research and strengthen extension activities in the country.
The Significance of Thematology to Methodological Innovation of Research on Chinese Narrative Literature

Field: Arts and Humanities (Social Sciences)

Thematology,originated from the mid-19th century,has maintained a close relationship with Chinese narrative literature.Great results have been achieved in the application of thematology to Chinese narrative literature research since the 20th century.The introduction of thematology has important impact upon the perspective and horizon of Chinese narrative literature research in terms of document collation and cultural analysis.
In Memoriam Francisco Munguía Villalta (1976-2020) El arte de estar con la gente

Field: Arts and Humanities (Social Sciences)

Francisco Munguía Villalta (1976-2020) was a talented, highly productive and multifaceted Costa Rican artist. He produced a vast work, in different formats and techniques. He believed in the transforming power of art and consequently produced a socially committed work guided by the conviction that art should be accessible, inclusive, participatory and educational. He developed a plastic language anchored in his vocation of graphic humor. This, together with his fondness for social volunteering and community work, allowed him to establish easy links of communication and an extraordinary familiarity with people. Its iconographic universe of comic strip and its narrative full of parody and satire lives in his stickers, ceramics and paintings. His mural works managed not only to change the urban landscape, but also to reaffirm a sense of community, since his participatory methodology aspired to restore the power of people and to enable them to take over their own public spaces. Without delving into a chronological review of the artist’s journey, nor a logical analysis of his extensive production, this document shares an overview of aspects that are considered emblematic in the work of Munguía Villalta. This is a tribute to his memory and a celebration of the vitality of his extraordinary plastic legacy.
Physical compatibility of milrinone lactate injection with intravenous drugs commonly used in the pediatric intensive care unit

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Journal Article Physical compatibility of milrinone lactate injection with intravenous drugs commonly used in the pediatric intensive care unit Get access Michael A. Veltri, Pharm.D., Michael A. Veltri, Pharm.D. Pediatric Clinical Specialist Department of Pharmacy Address correspondence to Dr. Veltri at the Department of Pharmacy, Carnegie 180, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287-6180 (mveltri@jhmi.edu). Search for other works by this author on: Oxford Academic Google Scholar Kim G. Conner, B.S. Pharm., M.AC. Kim G. Conner, B.S. Pharm., M.AC. Pediatric Senior Clinical Pharmacist Departments of Pharmacy and Pediatric GI/ Nutrition, The Johns Hopkins Hospital, Baltimore, MD Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 59, Issue 5, 1 March 2002, Pages 452–454, https://doi.org/10.1093/ajhp/59.5.452 Published: 01 March 2002
In situ control of GaN growth rate in nitrogen-limited regime

Field: Materials Science (Physical Sciences)

A novel approach for measuring the growth rate during GaN deposition under nitrogen-limited conditions (i.e., gallium-rich conditions) is presented. The method is based on the analysis of the variations in the optical signal measured by a pyrometer during a two-step process, the initial deposition of GaN in the Ga-rich regime and the subsequent growth of GaN through the consumption of the excess Ga under nitrogen flux. This approach provides a precise and accurate way to determine the GaN growth rate as a function of plasma generation parameters, such as nitrogen gas flux and RF power.
Phase 1 study of oral azacitidine (CC-486) plus R-CHOP in previously untreated intermediate- to high-risk DLBCL

Field: Medicine (Health Sciences)

Abstract Resistance to standard immunochemotherapy remains an unmet challenge in diffuse large B-cell lymphoma (DLBCL), and aberrant DNA methylation may contribute to chemoresistance. Promising early-phase results were reported with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) plus subcutaneous azacitidine, a hypomethylating agent. In this phase 1 study, we evaluated CC-486 (oral azacitidine) plus 6 cycles of R-CHOP in patients with previously untreated intermediate- to high-risk DLBCL or grade 3B/transformed follicular lymphoma. CC-486 doses of 100, 150, 200, or 300 mg given 7 days before cycle 1 and on days 8-21 of cycles 1-5 were evaluated; additional patients were enrolled in the expansion phase to examine preliminary efficacy. The primary objectives were to determine the safety and the maximum tolerated dose (MTD) of CC-486 in combination with R-CHOP. The most common grade 3/4 toxicities were hematologic, including neutropenia (62.7%) and febrile neutropenia (25.4%); grade 3/4 nonhematologic toxicities were uncommon (&lt;7%). The MTD was not established; 2 patients had dose-limiting toxicities (1 with grade 4 febrile neutropenia; 1 with grade 4 prolonged neutropenia). The recommended phase 2 dose was established as 300 mg. The overall response rate was 94.9%, with 52 patients (88.1%) achieving complete responses. With a median follow-up of 28.9 months, estimated 1- and 2-year progression-free survival rates were 84.1% and 78.6%, respectively. Overall, epigenetic priming with CC-486 before R-CHOP can be delivered with acceptable safety to patients with previously untreated intermediate- to high-risk DLBCL or grade 3B/transformed follicular lymphoma. ClinicalTrials.gov: NCT02343536.
Secondary Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Recurrent Epithelial Ovarian Cancer

Field: Medicine (Health Sciences)

In the 1990s, physicians started to study the combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for management of peritoneal surface malignancies. Favorable evidence from experimental data and retrospective clinical studies has supported use of combined treatment. This approach, however, is controversial because of major concerns regarding high morbidity and lack of evidence from randomized trials. This multi-institutional retrospective study from Italy was designed to assess the efficacy of combined CRS and HIPEC treatment in recurrent epithelial ovarian cancer (EOC) and to examine the safety profile of combined treatment. Prospective data were obtained from 4 Italian centers specializing in locoregional treatment of peritoneal surface malignancies. The patient population was composed of 56 patients with recurrent EOC who were 75 years or younger of ECOG (Eastern Cooperative Oncology Group) performance status 2 or less with a histological diagnosis of recurrent EOC. Cytoreductive surgery was performed followed by HIPEC performed using the closed-abdomen technique with cisplatin and doxorubicin or cisplatin and mitomycin C. The median patient age was 55.2 years. Primary study outcome measures assessed at a median follow-up time of 23.1 months were OS, progression-free survival (PFS), morbidity, and mortality rates. To assess the extent of peritoneal carcinomatosis, the peritoneal cancer index was determined intraoperatively. Residual disease was categorized according to the completeness of cytoreduction (CC). The median peritoneal cancer index was 15.2 (range, 4–30). Forty-seven of the patients had microscopic residual disease (CC-0), 7 had residual disease 2.5 mm or less (CC-1), and 1 had residual disease greater than 2.5 mm (CC>2). Fifteen patients (26.3%) experienced major postoperative complications. There were 3 postoperative deaths (procedure-related mortality, 5.3%). The median OS was 25.7 months (95% confidence interval [CI], 20.3–31.0 months), and the median PFS was 10.8 months (95% CI, 5.4–16.2 months). At the 5-year follow-up, OS and PFS were 23% and 7%, respectively. Multivariate analysis using the Cox proportional hazard model showed that the following variables were independent prognostic factors: ECOG performance status (P = 0.001), preoperative serum albumin (P = 0.008), and CC (P = 0.005). The authors conclude that CRS combined with HIPEC is a promising therapeutic option for recurrent EOC.
Ablepharon macrostomia syndrome in a Thai patient: case report and literature review

Field: Medicine (Health Sciences)

Abstract Ablepharon macrostomia syndrome (AMS) is a rare congenital disorder. To our knowledge, only 20 cases have been reported to date, and all in patients from Western countries. We report a case of AMS in a Thai patient, who presented at age 3 months with severe ectropion of both upper and lower eyelids, alopecia totalis, no palpable clitoris, and hypoplasia of both labia minora and labia majora. Trio whole exome sequencing analysis was performed, which revealed a heterozygous missense c.223G>A (p.Glu75Lys) variation in TWIST2 . To our knowledge, this is the first reported case of AMS in a patient from Thailand and the first reported case of AMS in Asia.
Maria G. PARANI, Reconstructing the reality of images. Byzantine material culture and religious iconography (11th to 15th centuries). The Medieval Mediterranean, 41

Field: Arts and Humanities (Social Sciences)

Abstract In the last decades an increasing interest in everyday life in Byzantium has been manifested, not the least stimulated by the Birmingham Spring Symposia. Official and private collections have been brought to light. Maria PARANI (P.) has ventured to write a study not only about official and everyday furniture and implements but in the same work about the transmission of imperial insignia to the ecclesiastical realm. This work is an impressive scholarly accomplishment, written with much enthusiasm with beautiful layout and excellent quality of the illustrations.
Cellular Site for Fibrinogen Synthesis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

THROMBOSIS as a major medical disorder has received much attention because of the great morbidity and mortality rates with which it is associated. Recently, anticoagulants and fibrinolytic drugs have been used to suppress formation of clots or to dissolve those clots already formed. In either situation fibrinogen occupies a central position as the precursor of fibrin in the thrombus. Examination of the literature provides very little information on the normal physiology of fibrinogen. Furthermore, the specific cell type responsible for fibrinogen synthesis has remained obscure. This paper directly approaches the question of the cellular site of fibrinogen production and attempts to study mechanisms which affect fibrinogen turnover, synthesis, storage, and release. The hepatic parenchymal cell was revealed as the place where fibrinogen is produced and may be stored when conditions are favorable. The fluorescent antibody technique and highly specific antifibrinogen sera were used for cellular localizations. The rate of fibrinogen
Family act - edited text with commentaries, instructions, court practice and subject index ; other sources of family law

Field: Social Sciences (Social Sciences)

Rijec je o novom izdanju komentara Obiteljskog zakona, koji je pripremljen kao odgovor na potrebu tumacenja zakonskih odredaba i instituta, osobito onih koji su novi, promijenjeni ili znakoviti za primjenu u praksi. Također, u svjetlu pristupanja Hrvatske Europskoj uniji, rad je dopunjen uputama na europske dokumente.
Study on siRNA reverseing MDR1 and MDR3 expression in breast cancer cells in adriamycin-resistance

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

[Objective] To investigate the reversal effect of gene silence of MDR1 and MDR3 gene induced by small interference RNA(siRNA) on adriamycin-resistance in MCF-7/ADR cells.[Methods] Two siRNAs targeted MDR1 and MDR3 gene specifically were transfered into MCF-7/ADR and MCF-7 cells.The apoptosis rate was determined by flow cytometry.50%inhibition concentration (IC_ 50 ) of adriamycin in MCF-7/ADR cells was determined by MTT in vitro.The expression of MDR1 and MDR3 mRNA was assessed by RT-PCR.[Results] The apoptosis rate of pSuppressor Neo ABCB1 transfected cells (18.21%± 1.65%) was higher than that of pSuppressor Neo ABCB4(9.07%±2.16%),P 0.05.The apoptosis rate of transfected cells was higher than that of blank-vector cells,P 0.01.The reversal effect in adriamycin of pSuppressor Neo ABCB1 vector was higher than that of pSuppressor Neo ABCB4 vector,P 0.05.The expression of MDR1 and MDR3 mRNA in plasmid transfected group was suppressed significantly,P 0.01. [Conclusions] siRNA targeting at MDR1 and MDR3 gene can reverse adriamycin-resistance in MCF-7/ADR cells.
Efficiency and Mechanism of Demulsification of Oil-in-Water Emulsions Using Ionic Liquids

Field: Chemistry (Physical Sciences)

In this work, 13 ionic liquids (ILs), including 9 halogenide ILs and 4 non-halogenide ILs, were evaluated as demulsifiers for a model oil-in-water emulsion prepared with heptane and water, where sodium dodecylbenzenesulfonate (SDBS) was used as a surfactant. The separating efficiency (the fraction of heptane that has phase separated from the emulsion) of ILs was investigated using bottle tests and tube tests. Bottle tests show that halogenide ILs exhibited very fast demulsification, and among non-halogenide ILs, only trihexyltetradecylphosphonium dicyanamide (P666,14[N(CN)2]) could demulsify effectively but slower than halogenide ILs. Tube tests suggest that the demulsification efficiency is correlated with the mole ratio of IL and SDBS. For all ILs showing effective demulsification, instead of the desired extraction of the surfactant to an IL phase, it was found that the demulsification mechanism was ion exchange between IL anions and DBS, driven by the large Gibbs energy of hydration of the anions of the sodium salts that dissolve in water. Regeneration of these ILs and surfactants requires water-free reversed ion exchange processes with sodium salts and with salts containing the IL anions, probably limiting commercial applicability of the use of these ILs for demulsification.
THERAPEUTIC EFFECTS OF PROGESTERONE ON PREMENSTRUAL SYNDROME IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

Field: Medicine (Health Sciences)

Introduction: Premenstrual Syndrome (PMS) is defined as a group of disorders characterized by emotional and physical symptoms that occur in the luteal phase of the menstrual cycle and subside following menstruation. The reported prevalence of severe PMS is variable between 3% and 24%. Etiology of PMS remains unknown but cyclical ovarian activity and the effect of estradiol and progesterone on the neurotransmitters serotonin and gamma aminobutyric acid appear to be key factors. One hypothesis that the cause of PMS is the deficiency of progesterone and its derivatives. Polycystic Ovary Syndrome (PCOS) is characterized with chronic anovulation and oligo-ovulation. Due to this there is a distinct deficiency of progesterone and its derivatives in PCOS. The aim of this study was to investigate the efficiency of progesterone therapy for PMS in woman with PCOS. Materials and methods A randomized double blind controlled trial was performed on 60 women with PCOS and PMS. This study was conducted at Holy Family Hospital, Rawalpindi between August 2018 and April 2019. In the study group (progesterone group = group A, n=30), progesteron in a total amount of 300 mg was prescribed for a per day basis on three times a day, and in the control group (placebo group=group B, n=30) placebo capsules, which were completely similar to progesterone capsules were prescribed from day 15 to day 25. The severity and duration of symptoms were compared in both groups before treatment and 3 months after the beginning of treatment with Visual Analog Scala (VAS). Participants were requested to answer questions about their recurrent experience of 16 symptoms during the premenstrual phase. Data were analyzed using the Statistical Package for Social Science. Results: We investigated 60 females (mean age progesterone group / placebo group= 26.6 ± 2,5/ 27 ± 1,8years; range = 18-35 years). Two or more premenstrual symptoms were detected in 95.5% of the participants. The most frequent symptoms are depression, anxiety, abdominal bloating, mood swings, breast tenderness. Statistical significant decline was seen in progesterone treatment group in depression, irritablity, anxiety, mood swing, abdominal bloating, sleeplessness, felt hopeless, breast tenderness, less interest in usual activities symptoms. Conclusion: In this study comparing progesterone therapy with placebo for PMS in women with PCOS, we found that women had much lower depression, irritability, anxiety, mood swing, abdominal bloating, sleeplessness, felt hopeless, breast tenderness, less interest in usual activities symptoms during progesterone treatment.
Accuracy of Estimates of Mean Daily Traffic: A Review

Field: Decision Sciences (Social Sciences)

A location’s mean daily traffic (MDT) is the expected traffic volume on a “typical” day, and AASHTO’s Guidelines for Traffic Monitoring Programs identifies 22 different uses for estimates of MDT. The problem of quantifying the “precision and bias” of short-count estimates of MDT is reviewed, with particular attention to the different sources of estimation errors. It is argued that early attempts to estimate the likely error of short-count estimates did not include errors from using incorrect seasonal or day-of-week adjustment factors. It is also indicated that incorrect adjustment can produce very substantial increases in estimation errors. Research on managing such adjustment errors is reviewed, leading to the conclusion that seasonal counts, rather than simple coverage counts, may be needed to produce accurate estimates of MDT when solid prior information concerning appropriate adjustment factors is lacking.
Combined active-passive immunization against tetanus in man.

Field: Medicine (Health Sciences)

A schedule for the prevention of tetanus in the injured, which has been in operation in the emergency department of a large hospital for over two years, is proposed. For the majority of nonimmunized persons, it is recommended that a dose of toxoid and 50 units tetanus immune globulin (human) (TIGH) be given, in separate sites, to be followed later by additional doses of toxoid for the completion of active immunization. Combined active-passive immunization with tetanus toxoid and 50 units TIGH gives a low level of passive immunity and stimulates early onset of active immunization. In combined active-passive immunization, adsorbed tetanus toxoid produced a significantly higher response than the fluid toxoid. The injection of 400 units TIGH somewhat suppressed the induction of immunity following the first dose of AlPO(4)-tetanus toxoid.
MEDEVA BV v THE COMPTROLLER-GENERAL OF PATENTS

Field: Arts and Humanities (Social Sciences)

H1 Supplementary protection certificate—Acellular vaccine compositions against whooping cough—Combination of active ingredients not all subject of basic patent—Whether combination ‘protected’ by basic patent—Whether special provisions for vaccines—Application for SPC refused—Appeal to Patents Court dismissed—Appeal to Court of Appeal—Reference to European Court of Justice
Biosensing with Oleosin-Stabilized Liquid Crystal Droplets

Field: Chemistry (Physical Sciences)

Abstract Liquid crystals (LCs) are rapidly emerging as novel platforms for chemical, physical, and biological sensing. With regards to biosensing, LCs can be used to detect amphiphiles such as lipids, fatty acids, digestive surfactants, and bacterial endotoxins. However, designing LC-based sensors in a manner that preserves their sensitivity and responsiveness to these stimuli, and possibly increasing the biocompatibility, remains challenging. In this work, we investigate the stabilization of LC droplets by oleosins, plant-sourced and highly surface active proteins due to their extended amphipathic helix. We show that purified oleosins, at sub-μM concentrations, readily stabilize nematic LC droplets without switching their alignment, allowing them to detect surfactants at μM concentrations. We give direct evidence of the localization of oleosins at the LC-water interface using fluorescent labelling, and show that the stabilized droplets remain stable over months. Interestingly, chiral LC droplets readily switch in the presence of nanomolar oleosin concentrations, an unexpected behavior that we explain by accounting for the energy barriers required for switching the alignment between the two cases. We thus set forth a two-fold conclusion: oleosin-stablized nematic LC droplets present a biocompatible and sustainable alternative for bioanalyte detection, while chiral LCs can be used as highly sensitive and non-invasive sensors for detecting amphipathic helices in biological systems.
Inhibition of pyruvate oxidation by skeletal muscle mitochondria by phenylpyruvate.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

1. Phenylpyruvate inhibits pyruvate plus malate oxidation in human and rat skeletal muscle mitochondria in state 3 and in the uncoupled state, it has, however, no effect in state 4. 2. Inhibition by phenylpyruvate of pyruvate oxidation by intact uncoupled rat muscle mitochondria was competitive, with the Ki value about 0.18 mM. 3. It is suggested that the inhibition of pyruvate oxidation is due to the action of phenylpyruvate on muscle pyruvate dehydrogenase, and is the principal cause of the elevated concentration of pyruvate and lactate in blood plasma of phenylketonuric patients.
Lądowe pluskwiaki różnoskrzydłe (Hemiptera: Heteroptera) Gdyni i okolic (Pobrzeże Bałtyku i Pojezierze Pomorskie) / Terrestrial true bugs (Hemiptera: Heteroptera) of the Gdynia area (Polish Baltic Coast and Pomeranian Lake District)

Field: Agricultural and Biological Sciences (Life Sciences)

The paper lists 191 true bug species representing 23 families collected from the early summer of 2020 to the autumn of 2022 within and close to the city limits of Gdynia (northern Poland). They include Emblethis denticollis Horváth, Galeatus affinis (Herrich-Schaeffer), Lygus wagneri Remane, Orthotylus tenellus (Fallén) and Tingis pilosa Hummel, all recorded for the first time in the Polish Baltic Coast region, and five other species that have been recorded from four to fifteen other localities in Poland: O. adenocarpi (Perris) (4), Psallus mollis (Mulsant et Rey) (5), O. virescens (Douglas et Scott) (11), Deraeocoris flavilinea (A. Costa) (13) and Acetropis gimmerthalii (Flor) (15). This brings the total number of true bug species recorded in the Gdynia region to 231.