jimnoneill/paper-to-field-training huggingface dataset:
Fungsi Staf Sekretaris Gereja Dalam Menunjang Pelayanan Di Gbi Imanuel Wamena

Field: Social Sciences (Social Sciences)

This research was written with the aim of mediating the problems faced by the congregation at GBI Imanuel Wamena, in terms of the performance of the church secretarial staff regarding diaconal services which was less than optimal, as well as providing understanding or input that secretarial staff should provide in supporting diakonia services. The author uses a qualitative descriptive method with a field study approach. Interestingly, the performance of the church secretary staff in terms of diaconal services is more focused on appropriate diaconal services to the existing congregation. Unfortunately, this can be a benchmark for the congregation that the performance of the church secretary staff in supporting diaconal services is clear and cannot be detrimental to their performance in the church organization. In ecclesiastical matters, cooperation or, more precisely, uninterrupted communication with church leadership can make services more effective. It was concluded that the performance of the church secretary at GBI Immanuel is required to work extra hard in improving directed diakonia services to the leadership or congregation, both in terms of informing incoming letters, service schedules with the help of the multimedia team, as well as efficient and effective reporting of financial data.AbstrakPenelitian ini ditulis bertujuan untuk mengemukakan permasalahan yang dihadapi oleh jemaat di GBI Imanuel Wamena, dari segi kinerja staf sekretaris gereja terhadap pelayanan diakonia yang kurang maksimal, serta memberikan pemahaman atau masukan yang semestinya dilakukan staf sekretaris dalam menunjang pelayanan diakonia. Penulis menggunakan metode kualitatif deskriptif dengan pendekatan studi lapangan, yang mengacu pada pokok bahasan masalah mengenai kinerja staf sekretaris di GBI Imanuel. Menariknya, kinerja staf sekretaris gereja dalam hal pelayanan diakonia lebih banyak terfokus pada pelayanan diakonia secara tepat kepada jemaat yang ada. Rupanya, hal ini dapat menjadi tolak ukur bagi jemaat bahwa kinerja staf sekretaris gereja dalam menunjang pelayanan diakonia jelas dan tidak dapat dibantah akan kinerjanya dalam organisasi gereja. Dalam perihal gerejawi, kerjasama atau lebih tepatnya komunikasi yang tidak pernah putus dengan pimpinan gereja dapat membuat pelayanan menjadi semakin efektif. Disimpulkan bahwa, kinerja sekretaris gereja di GBI Imanuel dibutuhkan untuk bekerja secara ekstra dalam meningkatkan pelayanan diakonia yang terarah, terhadap pimpinan atau jemaat, baik itu dari segi penginformasian surat masuk, jadwal pelayanan melalui bantuan tim multimedia, serta pelaporan data keuangan yang efisien dan efektif.
Abstract 2174: Inhibition of CDK8 kinase with SEL120-34A allows for a personalized approach in AML

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Inhibition of oncogenic transcriptional programs is recognized to be a promising therapeutic strategy. SEL120-34A is a novel inhibitor of Cyclin- dependent kinase 8 (CDK8), which regulates transcription by associating with the Mediator complex. SEL120-34A interacts with the ATP binding site of CDK8 in type I inhibitor fashion and forms several types of interactions, including halogen bonds with the protein’s hinge region and hydrophobic complementarities within its front pocket. Although the compound was only modestly active in solid tumor cell lines, it repressed phosphorylation of STAT5 Ser726 and could differentially inhibit viability of AML and ALL cell lines in vitro and in vivo, along with other type I CDK8 inhibitors. Transcriptomic analysis identified major transcriptional programs altered in responder cell lines, which strongly indicated that apart from repression of survival pathways, CDK8 inhibitors could induce differentiation in cell lines with leukemia stem cells characteristics. Further studies on a large panels of responder and non-responder cell lines identified robust biomarkers which could be used with high confidence for stratification and personalized approach in CDK8-dependent AML cases. Favorable pharmacokinetics, confirmed safety and in vivo efficacy in leukemia models provide the rationale for further clinical development of SEL120-34A. Citation Format: Tomasz Rzymski, Michal Mikula, Eliza Zylkiewicz, Agnieszka Dreas, Katarzyna Wiklik, Aniela Golas, Katarzyna Wojcik, Magdalena Masiejczyk, Iga Dudzicz, Katarzyna Kucwaj, Malgorzata Statkiewicz, Krzysztof Goryca, Aleksandra Grochowska, Aleksandra Cabaj, Jerzy Ostrowski, Urszula Kukliniska, Krzysztof Brzozka. Inhibition of CDK8 kinase with SEL120-34A allows for a personalized approach in AML [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2174. doi:10.1158/1538-7445.AM2017-2174
Electron-mass anisotropy in type-III HgZnTe-CdTe superlattices

Field: Physics and Astronomy (Physical Sciences)

Cyclotron-resonance experiments done in a novel superlattice, HgZnTe-CdTe, provide the first determination of the conduction-band dispersion in a type-III superlattice. The measured electron-mass anisotropy is strongly dependent on the CdTe layer thickness, in agreement with band-structure and Landau-level calculations. These calculations show also that the studied superlattices are semimetallic, consistent with the large valence-band offset (300 meV). Another cyclotron-resonance transition is observed, evidencing strongly the formation of a two-dimensional electron gas.
6059 Inequity in childhood developmental outcomes in an inner-London borough: a secondary analysis of children’s characteristics and the ASQ-3

Field: Health Professions (Health Sciences)

Objectives

Early childhood development shapes children's future well-being.1 2 The Ages and Stages Questionnaire-3 (ASQ-3) is used to assess children's development aged between 2–2.5 years as part of England's Healthy Child Programme (HCP).3 This study aims to use secondary data to understand whether children living in Lambeth experiencing risk factors for disadvantage, social vulnerability and different levels of health visiting input (Universal, Targeted and Specialist) are at greater risk of poorer developmental outcomes at age 2–2.5 years.

Methods

Data was cross-sectional and came from the local health visiting dataset. Chi-square and analysis of variance tests were used to test associations between children's characteristics, HCP-level and ASQ-3 outcomes. Logistic regression was used to further evaluate the association between HCP-level and ASQ-3 outcomes.

Results

The final sample included 12,712 children living in Lambeth who were assessed using the ASQ-3 at age 2–2.5 years between the 30th of June 2015 and the 2nd of August 2022. Sex, ethnicity, income deprivation affecting children index (IDACI) and HCP-level were very strongly associated with ASQ-3 outcomes (p<0.001). Males (Odds Ratio(OR) 2.33, 95%CI 2.13–2.55,p<0.001), Black children (OR 2.34, 95%CI 2.01–2.72,p<0.001) and children living in the most deprived areas (OR 2.13, 95%CI 1.76–2.59, p<0.001) had the highest odds of scoring below the expected ASQ-3 threshold, relative to White children, females and children living in the least deprived areas. After controlling for other variables, there was strong evidence that Targeted HCP was associated with five times the odds (OR 5.16, 95%CI 4.21–6.19, p<0.001) and Specialist HCP was associated with twice the odds (OR 2.13, 95%CI 1.45–3.12,p<0.001) of scoring below the expected ASQ-3 threshold compared with children receiving Universal HCP.

Conclusion

Early-years services need to target children at greater risk of poorer developmental outcomes in a way that reduces inequities and is universally proportionate. The HCP in Lambeth needs to be reviewed using a cross-disciplinary approach to ensure each HCP- level meets the needs of all families whilst considering the limited resources.

References

The United Nations Children's Fund (UNICEF). Early Childhood Development. Switzerland2022 [cited 05/08/2023. Available from: https://www.unicef.org/early-childhood-development. Early Years Healthy Development Review. The Early Years Healthy Development Review Report. England 2021. Department of Health. Healthy Child Programme: Two year review England; 2009.
Optical absorption spectra of thin GaInNAs single quantum wells investigated by means of piezoelectric photothermal spectroscopy

Field: Physics and Astronomy (Physical Sciences)

Recently developed compound semiconductor GaInNAs is a promising material for optical fiber communication. The absorption spectrum of thin GaInNAs layer (10-nm thickness) was observed by using our developed piezoelectric photothermal spectroscopy. The spectra revealed a step-like density of states and exciton formation in two-dimensional discrete levels in the quantum well. Effective mass of the conduction band was estimated to be 0.05m0 by assuming that the valence-band offset was negligible. Rapid thermal annealing relaxes a lattice defects and distortions, and this results in a blueshift of the spectrum.
Surgery in SCLC as first step of multimodality treatment.

Field: Medicine (Health Sciences)

186 patients received surgery for cure followed by aggressive randomized chemotherapy and PCI. After a median follow-up time of about 60 months the observed 4-year overall survival rate for patients completely resected was: 58% for 68 patients with pT1-3N0M0, and 33% for 27 patients with pT1-3 pN2M0 stages of SCLC. These promising results have to be confirmed by larger cooperative studies to support the recommendation to initiate surgery without delay, i.e. without preoperative chemotherapy for SCLC as well as for the non-SCLCs. From 148 patients in ISC study III after preoperative (neoadjuvant) chemotherapy only 12 received surgery for pT1-3N2M0 but only one of them survived 36 months and none 48 months p.o.
Myzel – Selforganization in Networked Worlds

Field: Computer Science (Physical Sciences)

Using a Proof of Concept (PoC) of Myzel, we tested a new concept for an online community game. In contrast to existing simulation games Myzel allows the players to negotiate and change the rules of their virtual world. Apart from minor technical restrictions they have to create rules for legislation, resources, economy political organizations and other areas. This should help players to understand the complex inner workings of modern societies. Myzel’s PoC was developed with the help of a small test community using extreme programming techniques. The PoC was tested in a controlled environment as well as in a free scenario. The results proved the validity of the game concept in most aspects. With small adaptations and a state-of-the-art user interface, Myzel should develop a great selforganized virtual society.
Hierarchical user interest modeling for Chinese web pages

Field: Computer Science (Physical Sciences)

User interest modeling is the core of personalized services. It is applied in the fields of information retrieval, data mining, e-commerce and personalized recommendation to improve the quality of information services. Most of traditional user interest models are built on VSM using keywords as the user interest. However, these models not only ignore the hierarchical granularity relations between keywords, but also ignore the use of domain knowledge hidden the specific concepts of users or the topics of interests. Thus, it is difficult to express the user interests accurately and reasonably in the user interest modeling. Motivated by this, we propose a Graph-based Chinese Phrases Hierarchical Clustering algorithm called GCPHC. It organizes the user interest in a hierarchy tree structure, designs the HowNet-based Maximum Matching Mapping method called HNM3 to map the user interest to topics of ODP, and builds a hierarchical user interest model labeled with the topic for each cluster. To achieve the optimal performance of our algorithm, we take into account of five correlation functions (including AEMI, AEMI3, IT, PS and Support) used in our GCPHC algorithm in cases varying with the data scale and the POS (part of speech). Extensive experimental studies demonstrate that our algorithm with the correlation function AEMI performs as well as that with AEMI3, and outperforms others in the cases with the data scale varying from 20 documents to 30 documents and nouns as terms. In these cases, the average RGC (Rate of Good Clusters) in our algorithm with the correlation function AEMI amounts to 74.7%, which is superior to our algorithm with other correlation functions.
Sacred Sites and Bio-diversity Protection

Field: Environmental Science (Physical Sciences)

Religious beliefs which relate to the protection of bio-diversity have been of concern more and more,especially because in many places there are sacred sites which have been formed because of religious beliefs . These sacred sites are a concentrated reflection of the impact of religious beliefs on bio-diversity. Sacred sites are specific natural and cultural landscapes worshipped deeply by the people from the perspective of religious belief. Accordingly,there are usually specific taboos which provide protection to these sites,sites such as sacred mountains,sacred forests,graveyard forests,geomancy forests and places where there are temples etc. Based on the research of others,this article divides sacred sites into three categories: 1. natural mountains and forests-these are found widely distributed in Southwest China. They usually do not cover a large area,and most of them are found near villages. 2. Temples or ancestral hallsthis kind of sacred sites takes as religious structures,stone carvings, and images as its core, combining them with the surrounding plants and water landscape. These kinds of sites show more traces of man’ s influence. 3. Famous mountains and great rivers and water landscapes. These kinds of sacred sites mostly consist of a combination of nature and culture,and have a deep religious atmosphere. Usually this kind of sacred site covers a large area. Therefore,their positive impact on the protection of bio-diversity is high.
Utilization of Duckweed as a Carbon Source for the Production of Lactic Acid

Field: Agricultural and Biological Sciences (Life Sciences)

Despite a great deal of research work on lactic acid fermentation in the past, the production of lactic acid from duckweed has yet to be investigated. In this study lactic acid was produced from duckweed thourgh existing technologies of saccharification/acid hydrolysis and fermentation of starch would been used for duckweed-to-lactic acid conversion. For this purpose, small fronds of duckweed plants was harvested, crushed and prepared into a solution. The duckweed slurry was subjected to acid hydrolysis. Then, fermentation of duckweed hydro-lysate was done in shake flasks using Lactobacillus plantarum species which was isolated from enset. The immediate solutions were anlysed by using UV-Spectrophotometer (concentration of lactic acid) and serial dilution methocd (viable cell count). Finally, the optimum operation conditions of fermentation (i.e. incubation time, pH and temperature) were determined by using design expert software (version 10.0.1). and the optimum incubation time, pH and temprature were 21 hours, 6.4 and 34 0 C respectively. The amount of lactic acid produced and number of viable cells at optimum operating conditions of fermentations were 15.6574g/L and 4.34004E+008.
Hepatocyte growth factor stimulates expression of plasminogen activator inhibitor type 1 and tissue factor in HepG2 cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract HGF is a powerful mitogen for both rat and human hepatocytes, epithelial cells and endothelial cells in vitro, and is angiogenic in vivo. It has considerable homology with plasminogen and has been shown to upregulate urokinase-type plasminogen activator (u-PA) in endothelial cells as well as u-PA and its receptor in kidney epithelial cells. In this study, we report that human recombinant HGF stimulates expression of plasminogen activator inhibitor type 1 (PAI-1) and tissue factor (TF) in the human hepatoma cell line HepG2. PAI-1 antigen as determined by a specific enzyme-linked immunosorbent assay increased up to threefold in conditioned media of HepG2. This increase was dose dependent with maximum stimulation achieved with a concentration of 50 ng/mL of hepatocyte growth factor (HGF). PAI-1 antigen also increased up to fourfold in the extracellular matrix in HGF treated HepG2. The production of the PAI-1 binding protein vitronectin (Vn) was not affected by HGF. In contrast, TF activity in HepG2 treated with HGF increased up to twofold. As determined by Northern blotting, PAI-1 and TF-specific mRNA were increased significantly in the presence of HGF, whereas Vn mRNA was not affected. The increase in PAI-1 and TF mRNA was also seen when HepG2 were incubated with HGF in the presence of cycloheximide, thereby indicating that de novo protein synthesis is not required to mediate the effect. u-PA could be detected neither in unstimulated or HGF-stimulated HepG2 cells on the antigen level nor on the mRNA level. In conclusion, our data give evidence that HGF, in addition to its proliferative effect for different cell types, is also involved in the local regulation of fibrinolysis and coagulation. One could speculate that HGF might modulate processes requiring matrix degradation by increasing the expression of the protease u-PA in one cell type and by upregulating the expression of the serine protease inhibitor PAI-1 in a different cell type. Because u-PA has been shown to activate latent HGF to the active form, it could furthermore be speculated that by upregulating PAI-1, which in turn could inhibit u- PA, HGF might regulate its own activation.
[Characteristics of the DNA content in the cells of human pigmented nevi and of beginning and developed malignant melanomas of the skin].

Field: Medicine (Health Sciences)

The comparative microspectrophotometric study of the DNA content in histological samples of 5 pigmented nevi, 3 dysplastic, 9 pigmented nevi with traits of malignization, and 10 malignant melanomas with the I-V invasion level by Clark has permitted determining a direct relationship between the expression degree and quality of the proliferation processes in neoplasia, on the one hand, and DNA quantity in nuclei, on the other hand.
Detection of ships for OTHR based on AR-MUSIC algorithm

Field: Computer Science (Physical Sciences)

In order to ensure the data rate, ship detection within short coherent integration time (CIT) is an operational requirement for over-the-horizon radar (OTHR). However, the resulting low Doppler resolution of short CIT brings difficulties in discrimination of the ship target peak and the powerful ocean clutter. To solve this problem, high resolution spectrum estimation techniques have been used to replace the conventional Fast Fourier Transform (FFT) for Doppler spectrum analysis. In this paper, a new spectrum estimation algorithm is proposed for ship detection by OTHR, which has higher Doppler resolution compared with the conventional method. In addition, in case that the signal-to-noise ratio (SNR) is low or the Doppler frequency of the target is close to that of the first-order ocean clutter Bragg peak, the presented algorithm can still effectively be used for ship detection for OTHR. The superiority of the proposed algorithm is illustrated by simulated OTHR data.
INFLUENCE OF GRANARY TYPE AND FARM PRACTICES ON THE RELATIVE ABUNDANCE OF INSECTS IN GRANARY RESIDUES

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract The abundance of nine stored-product species found in crop residues in farm granaries in the Prairie Provinces was influenced by farm practices, kinds of crops stored in the granaries, and the materials used in the construction of the granaries. Some species were found more frequently than expected on farms where there had been previous infestations ( Pyralis farinalis L.), or where there was livestock ( Cryptolestes ferrugineus [Stephens]). Fewer samples than expected were found infested with Cryptophagus varus (W. & C.), where insecticidal sprays were used, but more C . ferrugineus than expected were found where fumigants or insecticidal sprays were used. Fewer samples of canola residues than expected contained insects, but barley residues contained more insects than expected. Wooden granaries contained more insects than expected, except for C . ferrugineus . Cole’s coefficient of association showed that some species were often associated but other pairs of species such as Tribolium audax Halstead and Lathridius minutus L. were negatively associated. These relationships between species and their environments can be used to reduce the abundance of stored-products insects in farm granaries.
30-Day Cardiovascular Outcomes of Adult Patients Undergoing Non-cardiac Surgery at the University of Santo Tomas Hospital: A Prospective Cohort Study

Field: Medicine (Health Sciences)

BACKGROUND: Approximately 3,500 non-cardiac surgeries are being performed each year in the University of Santo Tomas Hospital (Manila, Philippines). No study has yet been made to evaluate the cardiovascular outcomes of these surgical patients. This prospective cohort study was performed to determine the 30-day cardiovascular outcomes in patients undergoing non-cardiac surgery in the private and clinical divisions of this institution and to evaluate the utility of currently used risk scoring systems. METHODS: There were 159 adult patients admitted from July to September 2015 for non-cardiac surgery who consented for inclusion. Risk stratification was done using the Revised Cardiac Risk Index (RCRI) and the Gupta Perioperative Risk calculator. They were followed up for major adverse cardiovascular events (MACE) until 30 days after the surgery. RESULTS: Out of 159 cases, nine patients (5.7%) developed MACE, eight of whom had a cardiac arrest. All major events occurred within 16 days following surgery. The number of comorbidities, presence of chronic kidney disease and emergency surgery significantly predicted perioperative MACE. RCRI had a sensitivity of 88.89%, specificity of 78.37%, positive predictive value (PPV) of 20% and negative predictive value (NPV) of 99.15% for predicting MACE. Gupta Perioperative Risk had a sensitivity of 77.78%, specificity of 84.46%, PPV of 23.3% and NPV of 98.43%. When combined, the two risk scoring systems showed a sensitivity of 88.89%, specificity of 77.70%, PPV of 19.5% and NPV of 99.14%. CONCLUSIONS: The 5.7% incidence of perioperative cardiovascular complications for non-cardiac surgery was similar to that seen worldwide. Physicians must be vigilant for these complications in the first 16 days following the surgery especially in patients undergoing emergency surgery and who have comorbidities like chronic kidney disease. RCRI is more sensitive while the Gupta Perioperative Risk is more specific and has higher positive predictive value for the occurrence of a MACE. Both scoring indices were useful in risk-stratifying patients.