jimnoneill/paper-to-field-training huggingface dataset:
How can we demonstrate the public value of evidence-based policy making when government ministers declare that the people ‘have had enough of experts’?

Field: Social Sciences (Social Sciences)

Abstract Recent political campaigns on both sides of the Atlantic have led some to argue that we live in the age of ‘post-factual’ or ‘post-truth’ politics, suggesting evidence has a limited role in debate and public policy. How can we demonstrate the public value of evidence-informed debate under those circumstances? Survey evidence on public attitudes to expertise offers some hope that the tone of much of this debate is unduly pessimistic. While policy-making always develops in an environment where evidence is contested, this paper will argue that understanding of the routines through which Ministers work and assimilate evidence is actually under-researched. Not only are Ministers open to evidence, but there is an institutional grounding for evidence-based policy in government. Meanwhile, the creation of devolved institutions has created new sites in the UK for evidence-based policy-making, despite the political tensions between UK and devolved governments. Drawing on academic and think tank insights, and experience as a Welsh Government Minister between 2007 and 2016, this paper argues for three key approaches for the academic community to adopt: understanding the temporal focus of ministers, building trust amongst ministers and those who advise them in the evidence-promoting capacity of the academic policy community, and shaping the wider authorising environment, including the media that contributes to the framing of key policy debates.
Better cognitive control of emotional information is associated with reduced pro-inflammatory cytokine reactivity to emotional stress

Field: Psychology (Social Sciences)

Stress is strongly associated with several mental and physical health problems that involve inflammation, including asthma, cardiovascular disease, certain types of cancer, and depression. It has been hypothesized that better cognitive control of emotional information may lead to reduced inflammatory reactivity to stress and thus better health, but to date no studies have examined whether differences in cognitive control predict pro-inflammatory cytokine responses to stress. To address this issue, we conducted a laboratory-based experimental study in which we randomly assigned healthy young-adult females to either an acute emotional stress (emotionally evocative video) or no-stress (control video) condition. Salivary levels of the key pro-inflammatory cytokines IL-1β, IL-6, and IL-8 were measured before and after the experimental manipulation, and following the last cytokine sample, we assessed participants' cognitive control of emotional information using an emotional Stroop task. We also assessed participants' cortisol levels before and after the manipulation to verify that documented effects were specific to cytokines and not simply due to increased nonwater salivary output. As hypothesized, the emotional stressor triggered significant increases in IL-1β, IL-6, and IL-8. Moreover, even in fully adjusted models, better cognitive control following the emotional (but not control) video predicted less pronounced cytokine responses to that stressor. In contrast, no effects were observed for cortisol. These data thus indicate that better cognitive control specifically following an emotional stressor is uniquely associated with less pronounced pro-inflammatory cytokine reactivity to such stress. These findings may therefore help explain why superior cognitive control portends better health over the lifespan.
The Inclusive Management of Paralympic Sport

Field: Social Sciences (Social Sciences)

We ground our understanding of the disability in the social model (e.g. Barnes, Mercer and Shakespeare, 2010), supporting that the responsibility for the disability lies with the society rather than in the individual (as conceptualized in the medical model). Sport, as a component of the overall society, is not exempt from the growing debate around the idea of social inclusion. Engaged in a comprehensive approach, this on-going doctoral research focuses on the management-related issues of inclusion in sport for athletes with a disability (e.g. Fay, 1999; Legg, Fay, Hums and Wolff, 2009). The aim of this study is to analyze the change-related patterns linked to the inclusion process of Paralympic sports in their relevant International ”Olympic” Sport Federations, which is a key strategic issue for the International Paralympic Committee. Based on the disability studies and the policy network theory (Koppenjan & Klijn, 2004), we explore two contrasted case studies (e.g. Gerring, 2007) in order to catch the significant historic milestones which have led (or not) to further inclusion in sport of athletes with a disability. Para-cycling (controlled by the Union Cycliste Internationale) and para-athletics (under the umbrella of the International Paralympic Committee) constitute the empirical frameworks. The Process Tracing methodology (Beach & Pederson, 2013) is mainly used to empirically investigate the causal mechanisms that might causally explain each case. By doing so, we simultaneously intend to develop a managerial model designed to facilitate the inclusion pattern in sport for athletes with a disability and to contribute to the development of the literature on inclusive management of disability sport (Misener & Darcy, 2014).
Consistency of a kind of general noncanonical warm inflation

Field: Physics and Astronomy (Physical Sciences)

The framework of a kind of noncanonical warm inflation is introduced, and the\ndynamical equations of this scenario are presented. We propose the slow roll\napproximations and give some redefining slow roll parameters in this scenario\nwhich remain dimensionless. Performing systemic stability analysis, we\ncalculate the slow roll conditions to guarantee that slow roll approximations\nhold. The slow roll conditions suggest slow roll inflation in general\nnoncanonical warm inflationary scenario can still exist, and in addition, the\nslow roll approximations are more easily to be satisfied. Then, a concrete\nDirac-Born-Infeld warm inflationary model is studied.\n
A Uniform Modeling of Networked Control System with Random Delays

Field: Computer Science (Physical Sciences)

The modeling of networked control system is the foundation of the analysis, design, and simulation. In this paper, the main drawbacks of the current literatures related to networked control system are discussed. Meanwhile, a uniform model is developed based on the linear time-invariable plant model, including the situations in which the network-induced delays are shorter or longer than sampling periods. Considering the dynamic features of controller, noise and packets dropout, the uniform model is built in the discrete stochastic formation, and then many conveniences are presented for the controller design and stability analysis.
Outcomes and experience of thoracic endovascular aortic repair for Stanford type B aortic dissection

Field: Medicine (Health Sciences)

Objectives To summarize the clinical experience of thoracic endovascular aortic repair(TEVAR) for Stanford type B aortic dissention. Methods Clinical data of 134 patients with Stanford type B aortic dissention were reviewed retrospectively,in order to analyze causes for complications,short-term and long-term effects during follow-up.Results Preoperative death occurred in 4 patients and 1 patient died without operation. There were 129 patients received TEVAR and cured. Left subclavian artery was partially covered in 27 patients(20.9%),completely covered in12 patients(9.3%). And there were type I endoleaks in 13 patients(10.1%),aortic dissection reverse peel to type A aortic dissection in 1 patient,hypoxemia in 23 patients(17.8%),renal failure requiring hemodialysis treatment in 9patients(7.1%),postoperative psychiatric symptoms in 37 patients(28.7%) and cerebral infarction in 3 patients. A follow-up ranged from 2 months to 5 years was conducted in 110 patients with a follow-up rate of 85.7%. Dissection distal to the stent was found in one case 1 and 1.5 years after surgery,who was performed operations to implant covered stents twice and partial occlusion for celiac artery. One patient received surgery in another hospital because of intestinal obstruction 2 months after TEVAR. One patient died from ruptured dissection at far-end of the stent 4 years after TEVAR.One patient died suddenly 3 months after surgery. Type I endoleaks disappeared in 11 patients but consistently appeared in 2 patients. Conclusions Emergency TEVAR for Stanford type B aortic dissention is safe and its short-term outcomes are good. To strengthen prevention of complications can further improve its clinical effect.
Effects of adjuvant PGE1 therapy following profundaplasty in patients with severe limb ischaemia. Early and long-term results.

Field: Medicine (Health Sciences)

In patients undergoing profundaplasty because of severe limb ischemia due to three-level occlusion, adjuvant intravenous 3-week treatment with PGE1 substantially improves not only the short-term results, but also the long-term outcome after five years in terms of patient survival and limb salvage.
Chemical Aspects of the Precipitin and Agglutinin Reactions.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical Aspects of the Precipitin and Agglutinin Reactions.Michael. HeidelbergerCite this: Chem. Rev. 1939, 24, 2, 323–343Publication Date (Print):April 1, 1939Publication History Published online1 May 2002Published inissue 1 April 1939https://pubs.acs.org/doi/10.1021/cr60078a009https://doi.org/10.1021/cr60078a009research-articleACS PublicationsRequest reuse permissionsArticle Views77Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Validating the Biological Activity of Fluorescently‐labeled IGF1 for in vivo Imaging

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

IGF1 is an important mediator for bone growth. Delivering IGF1 to avascular-cartilage plates is a major challenge. Because of the lack of penetrating blood vessels, solutes are transported to cartilage by diffusion from adjacent vasculature. Our lab established a technique to track the delivery of fluorescently labeled IGF1 to the avascular-cartilage plate using in vivo multiphoton imaging. IGF1 was labeled using Alexa Fluor 488. The labeled IGF1 was separated from free dye using a spin column, and the degree of labeling was evaluated using NanoDrop spectrophotometry. The biological activity of IGF1-Alexa Fluor 488 conjugate was investigated by treating metatarsal bones from young C57BL/6 mice with the conjugate in vitro. Skin and tendons were removed and the remaining tissues were fragmented into small pieces. The samples were treated for 90 minutes with 100 ng/ml IGF1, IGF1-Alexa Fluor 488, or left untreated. Samples were homogenized and processed for western blot analysis of total Akt and phosphorylated-Akt (p-Akt). GAPDH was used to normalize protein loading. Densitometric analyses were carried out using ImageJ. The results showed that IGF1 conjugate with Alexa Fluor 488 was functionally active and had the same biological effect as unlabeled IGF1. Processing samples in this way allows us to investigate other molecules involved in signaling and bone elongation such as IRS1 and ERK1/2.​ Supported by ASBMR GAP, UK-CCTS (NIH UL1TR000117), and NIH/NIAMS R15AR067451-01.
An Investigation of Objective Person-Environment Fit: The Dark Side of Intelligence

Field: Psychology (Social Sciences)

Most previous studies of Person-Environment fit have failed to use objective measures of the work environment that are independent of the person examined. The current research investigated the moderating role of group size (an objective measure obtained from company records), on the relationship between intelligence and pay satisfaction. The intelligence was measured as general intelligence or “g ” and “reasoning”. On the basis of data from 257 shop-floor workers in a factory, results indicated that group size moderated the relationship between intelligence and satisfaction with pay- the relationship was negative in large groups and positive in small groups.
Boethius and the Triple Ending of the Cent Balades

Field: Arts and Humanities (Social Sciences)

Journal Article BOETHIUS AND THE TRIPLE ENDING OF THE CENT BALADES Get access LORI WALTERS LORI WALTERS THE FLORIDA STATE UNIVERSITYTALLAHASSEE, FLORIDA Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume L, Issue 2, April 1996, Pages 129–137, https://doi.org/10.1093/fs/L.2.129 Published: 01 April 1996
DNA Synthesis during Yeast Sporulation: Genetic Control of an Early Developmental Event

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

In yeast the mating type alleles a and a also control sporulation; heterozygous strains ( a /α) sporulate while homozygous strains (α/α or a / a ) do not. Net DNA synthesis, an early event preceding sporulation, occurred normally in the heterozygous strains but did not occur in the homozygous strains. Therefore, the α/ a allelles also influence early development well before spore formation begins.
Organizing the Rotation of the Body of a Vibration Robot Around the Vertical

Field: Engineering (Physical Sciences)

The movement of a vibrating robot, consisting of a body, two homogeneous flywheels, and an unbalance, is considered. A mathematical model of plane-parallel motion is constructed. The principal possibility of unbalance control, which results in the rotation of the robot in the horizontal plane, is shown. The dependences of the body’s rotation angle on the system’s parameters are described. The conditions for a complete stop of the body after rotation are determined. The displacement of the body from the initial position is analyzed.
Statistical tree-based feature vector for content-based image retrieval

Field: Computer Science (Physical Sciences)

The efficiency of any content-based image retrieval system depends on the extracted feature vectors of individual images stored in the database. Generation of a compact feature vector with good discriminative power is a real challenge in the image retrieval system. This paper presents the experimentation carried out to generate compact feature vectors for a colour image retrieval system based on image content. It has two stages of operation. In first stage the energy compaction property of image transforms is used whereas in the second stage, the statistical tree approach is used for feature vector generation. Performance of image retrieval is tested using image feature database as per various performance evaluation parameters such as precision recall crossover point (PRCP) along with newly proposed conflicting string of images (CSI). With different colour spaces, image transforms and statistical measures, proposed approach achieves the reduction in the feature vector size with better discriminative power.
Design of a low-drop-out voltage regulator

Field: Engineering (Physical Sciences)

This report describes the design of a Low-Drop-Out Voltage Regulator (LDO) with fast load transient response without a large external capacitor. The emphasis of the design is to reduce the overshoot and undershoot voltage of the load transient response while still maintaining a stable operating condition. LDO is a voltage regulator which regulates the output voltage with much smaller voltage drop across power transistor. LDO is popular for its low noise output and fast load transient response. It consists of an error amplifier, a Power PMOS transistor and a voltage reference. In most application, the LDO is usually loaded with an off-chip capacitor to maintain the stability and performance. However, with a smaller external capacitor, the output voltage usually experience a high voltage overshoot or undershoot during load transient response, thereby degrading the performance of the LDO. This project begins with the study of the LDO load transient response and stability identifying parameters and factors affecting the performance. A capacitor-free LDO with damping-factor-control (DFC) frequency compensation was adopted as the basic LDO structure for the design. Two techniques namely charge pumping and feed forward are subsequently introduced to improve the load transient response. The idea of employing the charge pump is to enable the LDO to provide more current to the load to reduce the undershoot voltage when there is a sudden demand in load current during load transient. The feed forward technique is used to improve the reaction time of the LDO when there is a sudden reduction in the demand for load current. This is achieved by reducing the voltage controlling the Power PMOS to reduce the supply current to the load, thereby reducing the voltage overshoot. Simulation was carried out in Cadence Spectre using CSM 0.18m CMOS process. From the simulation results, the load transient response of the LDO employing the two proposed techniques improves significantly and met all the design specifications.
Spinning Slavery: The Role of the United States and UNICEF in the Denial of Justice for the Child Camel Jockeys of the United Arab Emirates

Field: Social Sciences (Social Sciences)

This article provides a detailed account of the use of foreign child jockeys in competitive camel racing in the United Arab Emirates (UAE). Although the extensive use of child jockeys ended in 2005, the initiation of a class action lawsuit for civil damages in a United States (US) federal district court in 2006 posed a serious risk to the reputation of the rulers of the UAE. The article describes the resulting public relations offensive, which required the post-fact construction of a substantive defence and embroiled both the United States and the United Nations Children's Fund (UNICEF) in a serious denial of justice for thousands of victims of child slavery.
The antidiarrheal efficacy of a proprietary amino acid mixture (enterade) in neuroendocrine tumor (NET) patients.

Field: Medicine (Health Sciences)

e22217 Background: Based on SEER database, gastroenteropancreatic neuroendocrine tumor (GEPNET) incidence has increased 6-fold from 1 in 100,000 cases to about 6 in 100,000 cases over past 3 decades. North American Neuroendocrine Tumor Society estimates that over 100,000 GEPNET patients (pts) are currently living in the United States. A common quality of life limiting symptom for GEPNET pts is diarrhea. Excessive serotonin production, short gut syndrome, steatorrhea, bile acid colitis or intestinal bacterial overgrowth are possible causes of diarrhea in these pts. A novel amino acid based oral rehydration solution (enterade) is currently being evaluated in a Phase II clinical trial for antidiarrheal effects in post bone marrow transplant patients (NCT02919670). We conducted a pilot study of enterade in neuroendocrine tumor pts with quality of life limiting diarrhea to evaluate its antidiarrheal efficacy. Methods: Medical records of all GEPNET pts treated with enterade for symptomatic diarrhea were evaluated. Pts were treated at the Markey Cancer Center from May 2017 to January 2018. Results: Thirty-five pts were identified. One 8 Oz enterade bottle BID for 2 wks was prescribed. Antidiarrheal efficacy data were available for 23 pts. Seven pts had small bowel neuroendocrine tumors (NET), 5 had bronchial NETs, 2 had colorectal NETs, 3 had NETs of unknown primary, 3 had gastric NETS, 2 had pancreatic NETs and one had high grade neuroendocrine carcinoma of the prostate. Fourteen pts had history of prior bowel resection either for primary neuroendocrine tumor resection or debulking. Fifteen patients were receiving somatostatin analogs. Seventeen out of 23 patients reported improvement in diarrheal symptoms. Twelve out of these 17 responders reported at least a 50 percent reduction in diarrhea frequency. Conclusions: Seventeen of 23 (73.9%) GEPNET pts reported improvement in diarrhea with enterade. Twelve of 23 pts (52.2%) reported more than 50% reduction in diarrhea frequency. A prospective Phase II study of enterade in GEPNET patients with quality of life limiting diarrhea is planned.
Differences in Body Composition, Energy Intake, Energy Consumption and Subjective Appetite among Female University Students according to Eating Attitude

Field: Medicine (Health Sciences)

The purpose of this study was to investigate the difference in body composition, energy intake, energy consumption and subjective appetite according to the difference of eating attitude among 60 female college students. The subjects were classified into 30 normal group and 30 abnormal eating attitude group through the eating attitude questionnaire. The results are as follows. Body composition, weight, LBM and BMI were significantly lower in the abnormal eating attitude group than the normal group (p .001). % Body fat was significantly higher in the abnormal eating attitude group than in the normal group (p.001). RMR, daily total energy consumption, energy intake, and energy intake were significantly lower in the abnormal eating attitude group than in the normal group (p.001), and the calorie deficit and deficit rate were significantly higher in the abnormal eating attitude group than in the normal group (p.001). There was a significant interaction effect of appetite (p.001). In the normal group, hunger appetite was higher at 08:00 and 21:00 than at 12:00 and 17:00, and in the abnormal eating group, hunger appetite was higher at 08:00 than at 12:00, 17:00 and 21:00. In addition, hunger appetite at 21:00 was higher in the eating disordered group than in the normal group. These results showed that female college students with abnormal eating attitudes classified by questionnaire showed low calorie intake despite high hunger appetite.
Anaesthetic Management of a Patient with Sub-Valvular Aortic Stenosis for Emergency Lower Segment Caesarean Section

Field: Medicine (Health Sciences)

Sub-valvular aortic stenosis (SAS) occurs due to a fibrous membrane or a muscular narrowing causing left ventricular outflow tract obstruction. The physiological changes of pregnancy may exacerbate the cardiac condition posing significant challenges for anaesthesia and surgery. A 34 years primigravida, with 32 weeks gestation, a known case of sub-valvular aortic stenosis presented in the emergency room in view of leaking/bleeding per-vagina. Risk factors such as tachycardia, decrease in afterload, preload and increased left ventricle contractility lead to exacerbation of the obstruction and should be avoided. We report a successful anaesthetic management of her lower segment cesarean section while balancing the physiological changes of pregnancy superimposed by pathology of the disease.