jimnoneill/paper-to-field-training huggingface dataset:
DEVELOPMENT OF A PERINEURAL INJECTION OF THE CAUDAL CERVICAL SPINAL NERVE ROOTS IN HORSES

Field: Veterinary (Health Sciences)

Neck pain in horses can result in lameness and poor performance and can occur from arthritis of cervical articular process joints (APJs). Current treatment consists of direct injection of corticosteroids into the cervical APJs; however, this does not alleviate pain in all horses. New bone formation around the APJ can also result in compression of the spinal nerve roots and pain. The purpose of this study was to develop an ultrasound-guided cervical perineural injection technique and assess the safety of performing the technique in normal healthy horses. An ultrasound-guided cervical perineural injection technique of the caudal cervical spinal nerve roots (CSNR 5–7) was developed in cadaveric necks of horses. Paramagnetic or iodinated contrast was injected and the distribution was evaluated using magnetic resonance (MR) or computed tomography (CT) imaging, respectively. The ability of the perineural injection technique to distribute contrast agent to the CSNR region was compared with intra-articular and periarticular injection techniques. In a second study, the safety of the ultrasound-guided perineural injection technique was evaluated in normal, healthy horses. Pain and swelling at the injection site, along with lameness, was evaluated before and after injection and compared to intra-articular injection of the cervical APJs. Perineural injections delivered contrast agent to the CSNR region 100% of the time, which was significantly greater than the ability of the intra- articular injection to deliver contrast to the CSNR region (p = 0.008). In the second study, the perineural injection techniques were found to be safe with no difference noted in pain, swelling or lameness compared to horses receiving intra-articular injection of the cervical APJs. Overall, the ultrasound-guided perineural injection technique developed in this study successfully delivered contrast agent to the CSNR region and was found to be safe. This technique could potentially be used for the diagnosis and treatment of cervical pain in horses, particularly in cases where intra-articular injection of the cervical APJ was not beneficial. Further studies are necessary to assess the effectiveness of the ultrasound-guided perineural injection technique in clinical horses suffering from neck pain due to impingement of the cervical spinal nerve roots.
A Study of Manufacturing Process Management in Ashok Sahakari Sakhar Karkhana Ltd.

Field: Business, Management and Accounting (Social Sciences)

In ASSK production control process starts with marketing department, where it get demands on the basis of current market trends and it acts as a basis for developing production plan.It involves coordination with various departments of ASSK, like it starts with marketing department and ends with logistics.ASSK"s main focus is on customer building by fulfilling their demands on time with great quality. Overall Production Process in ASSK is carried outMarketing department: Marketing department forecasts the demand and gives it to other departments which are directly involved in production activities.Production department: Production planning is carried out here based on the availability of the raw materials, finished goods in stock.Logistics: Logistics of ASSK works in coordination with production and marketing department where it gets Minimum Demand -In this, if the demand in the market is low then the ASSK must produce minimum demand to sustain in the market.Import finished products -ASSK thinks of its customer very much.If the plant is under shut down because of certain reason, the company delivers the finished products by importing from other companies to maintain good relationship with their customers.Focused customers -ASSK gives discount to customers who are taking the Products in bulk quantity and to its regular customers.Overall project learning is about understanding all above aspects which are required for the smooth functioning of the production planning and control.
SH1082866.09FU

Field: Agricultural and Biological Sciences (Life Sciences)

UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
The Design and Performance of an X-band Broadband Klystron With Peak Power of 1MW

Field: Physics and Astronomy (Physical Sciences)

This paper presents the design and measurement results of an X-band broadband klystron with a peak power of 1MW developed at Aerospace Information Research Institute, Chinese Academy of Science (AIRCAS). In the development of this klystron, the single electron beam with an electromagnetic focusing system was adopted to achieve a high beam transmission rate. Meanwhile, a filter-loaded over-lapping mode double gap coupling cavities output circuit (OMDGOC) and a pill-box output window were used to ensure the klystron has an operating bandwidth of 650MHz. The 1# klystron was tested under a 1 % duty ratio at 27 operating frequency points. The technical specifications of this klystron are as follows: peak power: over 1MW, efficiency: over 24.3 %, gain: over 37.1dB, beam transmission rate: over 96%, which meet the design requirements.
Supplementary Figures S1-S12 from Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>Supplementary Figures S1-S12. Figure S1. Ingenuity Pathway Analysis (IPA) and Netwalker analysis of the PLX4720-synthetic lethal genes. Figure S2. Effect of Selumetinib on the mitochondrial gene expression in high OxPhos MEL624 cell lines. Figure S3. Differential energy consumption and release in selumetinib-sensitive and resistant melanoma cell lines. Figure S4. Oxygen consumption in MEKi+mTORC1/2i combination-resistant and Ã¢??sensitive melanoma cell lines. Figure S5. Cellular effects of FDA approved single agent MEK and BRAF inhibitors Trametinib and Dabrafenib and their combinations with AZD8055. Figure S6. RPPA proteomic analysis of protein lysates from three combination-resistant (1) and three Ã¢??sensitive (2) BRAF mutant melanoma cell lines following MEK or mTORC1/2 inhibition. Figure S7. Correlation of MITF expression with selumetinib and AZD8055 combination synergy in 14 melanoma cell lines. Figure S8. Effect of selumetinib and AZD8055 on the cellular localization of MITF and consequence of MITF knockdown Figure S9. Comparative effects of AZD8055 and AZD2014. Figure S10. Drug concentration against percentage of cell growth inhibition. Figure S11. The proliferation of the A375, its resistant clones Ã¢??R1 and -R2, and WM35 and its resistant clones in presence of increasing concentrations of selumetinib, AZD8055 and their combination after 72 h treatment was determined as described in Figure S8. Figure S12. A) Ratio of PGC1ÃŽÂ± and MITF gene expression at the time of disease progression versus pre-treatment in the MGH cohort of patients treated with single-agent vemurafenib (MGH-25) or with dabrafenib + trametinib (all others). B) PGC1ÃŽÂ± expression in 917 cell lines of the Cancer Cell Line Encyclopedia (CCLE) representing 23 cancer types.</p>
Effects of a microbial organic-inorganic compound fertilizer on yield and quality of fuji apple in Weibei dry plateau

Field: Agricultural and Biological Sciences (Life Sciences)

By selecting apple orchards, we conducted comparative experiments to evaluate the effects of a microbial organic-inorganic compound fertilizer(experiment group) and conventional inorganic fertilizer(control group) on the the yield and quality of Fuji apple cultivated in Weibei dry plateau. The results showed that the microbial organic-inorganic compound fertilizer developed by Shaanxi Institute of Microbiology increased yield per 667 m2of Fuji apple, the increasement of yield ranged from 3.06% to 28.82%. Average weight was 233.88 g per apple, increased by 15.83%. Average commodity fruit rate was 80.80% with 8.67% increasement. Average saccharine degree was 13.52% with 4.79% increasement, and average firmness was 9.61 kg/cm2with 3.58% increasement. This study validated that the microbial organic-inorganic compound fertilizer had a significant effect on improvement of yield and quality of Fuji apple.
Design, Synthesis, and Pharmacological Evaluation of Monocyclic Pyrimidinones as Novel Inhibitors of PDE5

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Cyclic nucleotide phosphodiesterase type 5 (PDE5) is a prime drug target for treating the diseases associated with a lower level of the cyclic guanosine monophosphate (cGMP), which is a specific substrate for PDE5 hydrolysis. Here we report a series of novel PDE5 inhibitors with the new scaffold of the monocyclic pyrimidin-4(3H)-one ring developed using the structure-based discovery strategy. In total, 37 derivatives of the pyrimidin-4(3H)-ones, were designed, synthesized, and evaluated for their inhibitory activities to PDE5, resulting in 25 compounds with IC50 ranging from 1 to 100 nM and 11 compounds with IC50 ranging from 1 to 10 nM. Compound 5, 5,6-diethyl-2-[2-n-propoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one, the most potent compound, has an excellent IC50 (1.6 nM) in vitro and a good efficacy in a rat model of erection. It thus provides a potential candidate for the further development into a new drug targeting PDE5.
Implementation of Last Planner in a Medium-Sized Construction Site

Field: Decision Sciences (Social Sciences)

The paper address a pilot project in implementation of Last Planner initiated by the general contractor, Skanska, in a construction project of 6800 square metre made up of a kindergarten, junior high school and a sports and cultural centre. Excavation work started late autumn 2008 and the utility buildings are scheduled to be delivered to the owner in June 2010. The owner is the Municipality of Kristiansand. Action research is applied as research method, where academics take part in the change processes, together with professionals from the construction project and the general contractor’s head office. This paper concerns reflections from the ongoing construction process and is based on preliminary data. The first run is broadly in accordance with the Last Planner concept as outlined by Ballard. It is, however, identified a need to improve the system to link the output from the collective phase scheduling to production planning via the lookahead schedule and constraint analysis, which has been mis-conceptualised in the early phase of the project. The most successful part of the implementation study so far is several phase planning processes, in which the technical sub-contractors have been taking active part in the collective organised planning process. It is too early in the project to see if this also leads to improved PPC in production, but it is expected that it will. However, the same quality of coordination is missing for the architect and the subcontractor for site work. It is identified a number of empirical difficulties in the implementation the process. The largest challenge seems to be the relationship between the architect, the general contractor and the owner, as the pattern in the relationship appears to be dysfunctional in order to create best possible condition for cooperation, and which need to be further studied. Moreover is it identified proposals for further improvements in the Last Planner concept.
A Robust α-l-Fucosidase from Prevotella nigrescens for Glycoengineering Therapeutic Antibodies

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Eliminating the core fucose from the N-glycans of the Fc antibody segment by pathway engineering or enzymatic methods has been shown to enhance the potency of therapeutic antibodies, especially in the context of antibody-dependent cytotoxicity (ADCC). However, there is a significant challenge due to the limited defucosylation efficiency of commercially available α-l-fucosidases. In this study, we report a unique α-l-fucosidase (PnfucA) from the bacterium Prevotella nigrescens that has a low sequence identity compared with all other known α-l-fucosidases and is highly reactive toward a core disaccharide substrate with fucose α(1,3)-, α (1,4)-and α(1,6)-linked to GlcNAc, and is less reactive toward the Fuc-α(1,2)-Gal on the terminal trisaccharide of the oligosaccharide Globo H (Bb3). The kinetic properties of the enzyme, such as its Km and kcat, were determined and the optimized expression of PnfucA gave a yield exceeding 30 mg/L. The recombinant enzyme retained its full activity even after being incubated for 6 h at 37 °C. Moreover, it retained 92 and 87% of its activity after freezing and freeze-drying treatments, respectively, for over 28 days. In a representative glycoengineering of adalimumab (Humira), PnfucA showed remarkable hydrolytic efficiency in cleaving the α(1,6)-linked core fucose from FucGlcNAc on the antibody with a quantitative yield. This enabled the seamless incorporation of biantennary sialylglycans by Endo-S2 D184 M in a one-pot fashion to yield adalimumab in a homogeneous afucosylated glycoform with an improved binding affinity toward Fcγ receptor IIIa.
Optical MEMS accelerometer sensor relying on a micro‐ring resonator and an elliptical disk

Field: Engineering (Physical Sciences)

Here, a novel optical micro‐electro‐mechanical systems (MEMS) accelerometer sensor based on a micro‐ring resonator and an elliptical disk is proposed. The designed optical MEMS accelerometer is then analysed to obtain its functional characteristics. The proposed optical MEMS sensor presents an optical sensitivity of 0.0025 nm/g, a mechanical sensitivity of 1.56 nm/g, a linear measurement range of ±22 g, a first resonance frequency of 13.02 kHz, and a footprint of 34 μm × 50 μm. Furthermore, the achieved functional characteristics of the proposed accelerometer are compared to several recent contributions in the related field. According to this comparison study, the present optical MEMS accelerometer can be a suitable device for many applications ranging from consumer electronics to inertial measurement units.
Our allegiance - Australians or Global citizens

Field: Arts and Humanities (Social Sciences)

Why, you might ask (and my colleagues certainly are), does an intellectual property lawyer use an occasion like this to speak of globalisation and what may seem the internationalist cant of the lunatic fringe? Part of the reason is tied up with just missing out on conscription to the Vietnam war and how it galvanised my ideas about patriotism. Other parts derive from my sense of community, having lived almost a third of my life in different parts of the world. Other parts of the reason relate to what first attracted me to intellectual property law some twenty years ago. Essentially it was the high public international law content of the subject. International law struck me as more legitimate than domestic law, not because it was democratically formed, often to the contrary, but rather it implicitly conceived of a supranational public interest…
Fission and reorganization of maternity colonies by human disturbance in the greater horseshoe bat, Rhinolophus ferrumequinum

Field: Agricultural and Biological Sciences (Life Sciences)

(Uploaded by Plazi for the Bat Literature Project) The greater horseshoe bat, Rhinolophus ferrumequinum, is a large cave-dwelling bat and is commonest among cave-dwelling bat species in Japan. Cave-dwelling bats are very sensitive during the maternity season, and disturbance to maternity colonies often results in a serious impact on regional populations. However, a casual observation revealed R. ferrumequinum overcame serious accidental human disturbance by securing a new maternity cave and forming a new colony. The ability of R. ferrumequinum to respond flexibly to unexpected disturbance may be advantageous for the prosperity as the dominant Japanese cave-dwelling bat.
MAGIC Observations of the Unidentified γ-Ray Source TeV J2032+4130

Field: Physics and Astronomy (Physical Sciences)

We observed the first known very high energy (VHE) gamma-ray emitting\nunidentified source, TeV J2032+4130, for 94 hours with the MAGIC telescope. The\nsource was detected with a significance of 5.6 sigma. The flux, position, and\nangular extension are compatible with the previous ones measured by the HEGRA\ntelescope system five years ago. The integral flux amounts to\n(4.5+-0.3stat+-0.35sys)x10^{-13} ph cm$^{-2}$ s$^{-1}$ above 1 TeV. The source\nenergy spectrum, obtained with the lowest energy threshold to date, is\ncompatible with a single power law with a hard photon index of\nGamma=-2.0+-0.3stat+-0.2sys.\n
Bioinspired Adaptable Indwelling Microneedles for Treatment of Diabetic Ulcers

Field: Medicine (Health Sciences)

Abstract Microneedles provide an effective strategy for transdermal drug delivery. Many endeavors have been devoted to developing smart microneedles that can respond to and interact with pathophysiological environments. Here, novel bioinspired adaptable indwelling microneedles with therapeutic exosome encapsulation are presented for diabetic wound healing by a combined fabrication strategy of template replication and 3D transfer printing. Such microneedles are composed of mesenchymal stem cell (MSC)‐exosomes‐encapsulated adjustable poly(vinyl alcohol) (PVA) hydrogel needle tips and detachable 3M medical tape supporting substrate. As the mechanical strength of the PVA hydrogel is ionically responsive due to Hofmeister effects, the hardness of the resultant microneedle tips can be upregulated by sulfate ions to ensure skin penetration and be softened by nitrate ions after tip–substrate detachment to adapt to the surrounding tissue and release exosomes. Because the MSC‐exosomes can effectively activate fibroblasts, vascular endothelial cells, and macrophages, the indwelling microneedles are demonstrated with the function of promoting tissue regeneration and diabetic wound healing in full‐thickness cutaneous wounds of diabetic rat models. These features indicate that the bioinspired adaptable indwelling microneedles are with practical values and clinical prospects in tissue and wound regeneration.
Clinical significance of chemokine receptor (CCR1, CCR2 and CXCR4) expression in human myeloma cells: the association with disease activity and survival.

Field: Medicine (Health Sciences)

This study indicates that the chemokine receptor expression profile of MM cells correlates with disease status and survival of MM patients. This observation might reflect impaired chemoattraction and retention of MM cells within the bone marrow microenvironment, resulting in disease progression.
HUBUNGAN ANTARA STATUS SOSIAL EKONOMI DENGAN PERSEPSI MASYARAKAT TENTANG GANTUNG DIRI DI KECAMATAN KARANGMOJO KABUPATEN GUNUNGKIDUL YOGYAKARTA

Field: Social Sciences (Social Sciences)

The Purpose of research was to determine the relationship between socioeconomic status with public perception of suicide. This research was corelation descriptive quantitative. The population in this study was district Karangmojo Gunungkidul's people age 55 to 60 years amounted to 3.091 people. The sample in this study amounted to 356 people. The technique of collecting data using questionnaires. The analysis used is regression analysis and partial correlation. The results of this research the of socioeconomic status factor made moderate category (79.78%), then the result of the public perception of suicide negative category (81.74%), more than public perception of suicide positive category (18.26%). In conclusions there was a relationship between socioeconomic status with public perceptions of suicide in Karangmojo Gunungkidul Yogyakarta.Keywords: socioeconomic status, public perception of suicide
Calculus at the duct orifice of the submandibular gland in a patient with an edentulous jaw: A case report and literature review

Field: Dentistry (Health Sciences)

Rationale: The intricate and uncontrollable etiology of sialolithiasis compels clinicians to focus solely on disease management, often overlooking the underlying causes of sialolithiasis and neglecting patient education regarding preventive measures. The use of the multidisciplinary Salivary Gland Association questionnaire enables the identification of benign salivary gland lesions and evaluation of patients’ quality of life. Patient concerns: Wanting to remove foreign body from the bottom of the right lower side of the mouth. Diagnoses: Ductal calculus of the right submandibular gland. Interventions: We present a case of calculi in the right submandibular duct orifice of a 66-year-old male patient with an edentulous jaw. The patient reported discovering foreign bodies on the floor of the mouth persisting for 1 week without experiencing any discomfort and requested treatment for these foreign bodies. Subsequently, the patient underwent a transoral sialolith extraction. Outcomes: The patient experienced no postoperative discomfort, and the submandibular gland texture and salivary secretion function were normal after 8 weeks of follow-up. The patient’s Multidisciplinary Salivary Gland Society (MSGS)/Q10 score decreased significantly 6 months after surgery. Lessons: Sialolithiasis may remain asymptomatic throughout its course, and early intervention and treatment can effectively prevent severe complications. The MSGS/Q10 questionnaire may be a valuable tool.
Human milk bank in a district general hospital.

Field: Health Professions (Health Sciences)

A human milk bank was organised in the special care baby unit of a district general hospital. The staff of the unit and members of a voluntary organisation helped to contact donors and arrange collection of milk samples. Over two years 2093 samples of expressed breast milk were collected from 187 donors and examined bacteriologically. Of these samples, 1171 (56%) grew no bacteria. If the organism count exceeded 2.5 X 10(6)/1 but was less than 1 X 10(9)/1 samples were subjected to mild heat treatment. If the count exceeded 1 X 10(9)/1 the milk was not fed to babies. Sixty-five babies received milk from the bank during the second year. Although these infants were vulnerable, mortality and morbidity were not adversely affected by the banked milk they received. The cost of establishing and running a human milk bank need not be high. Extensive resources such as extra staff and laboratory and transport facilities were not needed. Enthusiastic co-operation and good will between hospital staff, voluntary helpers, and donors contributed greatly to the success of the scheme.