jimnoneill/paper-to-field-training huggingface dataset:
Daclatasvir plus sofosbuvir, with or without ribavirin, achieved high sustained virological response rates in patients with HCV infection and advanced liver disease in a real-world cohort

Field: Medicine (Health Sciences)

Objective We assessed the effectiveness and safety of daclatasvir (DCV) plus sofosbuvir (SOF), with or without ribavirin (RBV), in a large real-world cohort, including patients with advanced liver disease. Design Adults with chronic HCV infection at high risk of decompensation or death within 12 months and with no available treatment options were treated in a European compassionate use programme. The recommended regimen was DCV 60 mg plus SOF 400 mg for 24 weeks; RBV addition or shorter duration was allowed at physicians' discretion. The primary endpoint was sustained virological response at post-treatment week 12 (SVR12). Results Of the 485 evaluable patients, 359 received DCV+SOF and 126 DCV+SOF+RBV. Most patients were men (66%), white (93%) and treatment-experienced (70%). The most frequent HCV genotypes were 1b (36%), 1a (33%) and 3 (21%), and 80% of patients had cirrhosis (42% Child–Pugh B/C; 46% Model for End-Stage Liver Disease score >10). SVR12 (modified intention-to-treat) was achieved by 91% of patients (419/460); 1 patient had virological breakthrough and 13 patients relapsed. Virological failure was not associated with treatment group (adjusted risk difference DCV+SOF minus DCV+SOF+RBV: 1.06%; 95% CI −2.22% to 4.35%). High SVR12 was observed regardless of HCV genotype or cirrhosis, liver transplant or HIV/HCV coinfection status. Twenty eight patients discontinued treatment due to adverse events (n=18) or death (n=10) and 18 died during follow-up. Deaths and most safety events were associated with advanced liver disease and not considered treatment related. Conclusions DCV+SOF with or without RBV achieved high SVR12 and was well tolerated in a diverse cohort of patients with severe liver disease. Trial registration number NCT0209966.
Do projeto de tradução de Liffey Swim, de Jessica Traynor, para o processo de tradução do poema sin-eater

Field: Arts and Humanities (Social Sciences)

Liffey Swim is a book of poems by the Irish writer Jessica Traynor (2015). It features characteristics to contemporary Irish literature, such as Irish identity and local culture related to other cultures. The Liffey Swim translation project takes into account Irishness alongside the theoretical and methodological reflections on translation of poetry through translation stages that observed form and content. This article presents a two-step result from the translation process of one of the poems, Sin-eater. The poem depicts a death ritual in Ireland, one of the defining themes of Irish literature. The first stage comprises the result of a cultural and linguistic revision, while the second stage focused on the rhythm and other phonetic aspects, for the reconstruction of image and spirit.
The clinical analysis of Pioglitazone metformin tablets and Aspart 30 in patients with T2MD

Field: Medicine (Health Sciences)

Objective To investigate the effect of Pioglitazone metformin tablets and Aspart 30 ton glucose,lipids,glycated hemoglobin,C-peptide,BMI,insulin dose and hypoglycemia in Type II diabetes.Methods 300 patients with T2 MD were randomly divided into control group(n=150)and observation group(n=150).The control group was treated with Aspart 30 and observation group with Pioglitazone metformin tablets and Aspart 30.The levels of blood lipids,insulin function were analyzed.Results The levels of FPG,2hPG,HbAc,TC,TG and LDL-C of observation group were significantly lower than that of the control group and the levels of HDL-C of observation group was higher than that of control group(P0.05).The levels of HoMA-IR of observation group was lower than that of the control group,while the levels of B cell function index,fasting C-peptide(C-P),postprandial 2hC-P(2hC-P)of observation group were higher(P0.05).The rate of observation group of postprandial hypoglycemia incidence was1.33%and control group the incidence of hypoglycemia was 10.67%(P0.05).Before treatment,The levels of observation group of body mass index,blood glucose of two groups were not statistically significant(P0.05).The levels of mass index,blood glucose,body mass index of control group were higher than that of the observation group(P0.05).Conclusion Pioglitazone metformin tablets and Aspart 30 can improve the level of glucose and lipid islet function with T2 MD,while the Pioglitazone metformin tablets can be lowered and raised Visfatin levels of ghrelin levels in T2 MD sugar control mechanism of action.
Association of glycogen synthase phosphatase and phosphorylase phosphatase activities with membranes of hepatic smooth endoplasmic reticulum

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

A detailed investigation was conducted to determine the precise subcellular localization of the rate-limiting enzymes of hepatic glycogen metabolism (glycogen synthase and phosphorylase) and their regulatory enzymes (synthase phosphatase and phosphorylase phosphatase). Rat liver was homogenized and fractionated to produce soluble, rough and smooth microsomal fractions. Enzyme assays of the fractions were performed, and the results showed that glycogen synthase and phosphorylase were located in the soluble fraction of the livers. Synthase phosphatase and phosphorylase phosphatase activities were also present in soluble fractions, but were clearly identified in both rough and smooth microsomal fractions. It is suggested that the location of smooth endoplasmic reticulum (SER) within the cytosome forms a microenvironment within hepatocytes that establishes conditions necessary for glycogen synthesis (and degradation). Thus the location of SER in the cell determines regions of the hepatocyte that are rich in glycogen particles. Furthermore, the demonstration of the association of synthase phosphatase and phosphorylase phosphatase with membranes of SER may account for the close morphological association of SER with glycogen particles (i.e., disposition of SER membranes brings the membrane-bound regulatory enzymes in close contact with their substrates).
The determinants of extreme commodity prices

Field: Economics, Econometrics and Finance (Social Sciences)

Fat-tailed commodity price innovations are well-documented in the literature and long recognized as disruptive for consumers and producers, yet little is known about what factors drive such extreme events. Utilizing a wide range of factors from the economics and finance literature and quantile regression techniques, we shed light on this issue. Our models explain more variation in extreme than in median price innovations. Common global financial and demand factors account for a greater proportion of extreme daily spot price variations than do commodity-specific factors such as basis and open interest. Financialization of commodity markets, via significant and increasing co-variation of extreme spot price innovations with US equity market and trade-weighted US dollar returns, appears to be a major driver of extreme events in the 2000-2009 period.
Indica by L. D. Barnett - 1.The Bhagavadgītā. Translated from the Sanskrit with an introduction, an argument, and a commentary, by W. Douglas P. Hill M.A. 9 × 6, pp. x + 303. London, Oxford printed: Oxford University Press, 1928

Field: Arts and Humanities (Social Sciences)

Indica by L. D. Barnett - 1.The Bhagavadgītā. Translated from the Sanskrit with an introduction, an argument, and a commentary, by W. Douglas P. Hill M.A. 9 × 6, pp. x + 303. London, Oxford printed: Oxford University Press, 1928 - Volume 61 Issue 1
THE DYNAMICS OF SOCIAL CAPITAL DURING PUBLIC PARTICIPATION: NEW KNOWLEDGE FROM AN ON-GOING MONITORING

Field: Social Sciences (Social Sciences)

The mutual impacts between public participation and social capital has been thoroughly investigated, but little is known about the dynamics of social capital during a participative process. To fill such a gap, an ad-hoc monitoring system of social capital was implemented along an actual participative procedure about the future of an University site. Results show that - i) social capital evolution can follow non-monotonic patterns; ii) different dynamics of social interaction may occur that impact the quality of participation; iii) different participatory tools may lead to different dynamics of social capital; iv) repeated measurements of social capital generate a memory effect which reduces the variation of social capital itself. We also describe relevant drawbacks (resource consuming activities, reduced number of participants, etc.) which may reduce the applicability of the proposed approach. We conclude discussing when an on-going monitoring process is worth to be implemented, and we also describe some relevant side results for those interested to the issue of public participation - i) the announcement of the procedure already generated relevant individual learning; ii) the individual interviews were recognized as an essential learning moment, so we suggest including them into the design of any participative process.
Greenbug Resistance in Commercial Sorghum Hybrids in the Seedling Stage12

Field: Agricultural and Biological Sciences (Life Sciences)

Journal Article Greenbug Resistance in Commercial Sorghum Hybrids in the Seedling Stage Get access Jac Morgan, Jac Morgan Kansas State University, Manhattan, KS 66506 Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Wilde, G. Wilde Kansas State University, Manhattan, KS 66506 Search for other works by this author on: Oxford Academic PubMed Google Scholar D. Johnson D. Johnson Kansas State University, Manhattan, KS 66506 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 73, Issue 4, 1 August 1980, Pages 510–514, https://doi.org/10.1093/jee/73.4.510 Published: 01 August 1980 Article history Received: 14 February 1980 Published: 01 August 1980
Effect of salt and water stress on gas exchange, dry matter production and K+/NA+ ions selectivity in soybean

Field: Agricultural and Biological Sciences (Life Sciences)

The experiment was conducted in a vinylhouse at the Banghabandhu Sheikh Mujibur Rahman Agricultural University, Bangladesh during January to May, 2012 to evaluate the effect of salt and water stress on gas exchange characters, dry matter production and K+/Na+ ions selectivity in three selected soybean genotypes, namely Galarsum, BD 2331 and BARI Soybean-6. The genotypes were exposed to six treatments viz. (i) control (tap water), (ii) water shortage (irrigation with 70% depletion of available soil water when leaf began to wilt at 10:00 am), (iii) 50 mM NaCl irrigation, (iv) 50 mM NaCl irrigation + water shortage, (v) 75 mM NaCl irrigation, and (vi) 75 mM NaCl irrigation + water shortage conditions. The results revealed that 75 mM NaCl salt + water stress treatment drastically reduced stomatal conductance, photosynthesis and transpiration rate irrespective of soybean genotypes. However, the genotype Galarsum showed minimum transpiritional water loss (1.45 mmol H2O m-2 s-1) and maximum photosynthesis (20.45 μmol CO2 m-2 s-1) as compared to BD 2331 and BARI Soybean-6 under 75 mM NaCl salt + water stress condition. Combined salt and water stress caused greater inhibition of shoot growth than either of the two in soybean. The shoot dry weights were decreased to 24.58, 23.00 and 21.57% of the control in Galarsum, BD 2331 and BARI Soybean-6, respectively at 75 mM NaCl salt + water stress. The genotype Galarsum accumulated higher amount of K+ (1.19%) and lower amount of Na+ ( 0.11%) in leaf tissue under 75 mM NaCl salt + water stress. Results indicated that the genotype Galarsum was more capable to cope with the high levels of salt under water stress condition than the other two genotypes.Bangladesh J. Agril. Res. 42(3): 487-501, September 2017
Alterations in methylation and SNPs of OPRM1 gene show lack of association with heroin (nyaope) consumption in South African males of African ancestry

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Nyaope is a highly addictive heroin derivative that elicits its effects via the -opioid receptor. Gene mutations and (cytosine-phospho-guanosine) CpG methylation, alter the function of the -opioid receptor gene (OPRM1) and protein. The single nucleotide polymorphisms (SNPs) rs1799971 (118 A>G) and intronic rs3778150 (T>C) in the OPRM1 have previously been associated with heroin use. The SNP rs1799971 can influence methylation levels of OPRM1 and alter mRNA and protein expression. This study compared the degree of OPRM1 methylation and allele frequency of SNPs rs1799971 and rs3778150 in black South African male nyaope users (n=200) to age-and gender-matched controls (n=55).DNA was extracted from whole blood samples, and analysed by methylation-specific PCR and sequencing to determine methylation frequencies across 29 CpGs within the OPRM1promoter gene region. SNPsrs1799971 (118 A>G) and rs3778150 (T>C) were assessed using SNP genotyping Taqman assays.Using a positive methylation assignment method, most CpGs were significantly more unmethylated in nyaope users than in controls. Using a partial methylation assignment method, most CpGs displayed significantly higher percentages of partial methylation in nyaope users than in controls. The AG genotype frequency for SNP (118 A>G), was higher in controls than in nyaope users while other genotypes (AA & GG) for SNP rs1799971 and (TT, CT, CC) SNP rs3778150 were broadly similar in both groups. There was no correlation observed between nyaope consumption and the presence of SNP rs1799971 and/or rs3778150 in the study populations.This study provided evidence that methylation may not be associated with the intake of nyaope and that SNPs rs1799971 and rs3778150 did not alter the methylation status of the OPRM1 promoter gene or contribute to nyaope addiction in a black South African male population.
Assessing the Development of the Sales Profession

Field: Business, Management and Accounting (Social Sciences)

AbstractAs we celebrate the silver anniversary of this journal, it is time to assess the development of sales as a profession. This paper uses the sociology of work literature to develop six criteria society uses in making the attribution of a work group as a profession. Sales is then examined on each of those six dimensions. It is concluded that our discipline meets or exceeds four of the requirements, has mixed results on one construct, and falls short on another criterion. Progress will require the development and enforcement of an ethical code. A strong professional association for all salespeople across all industries could also be very useful in this regard. Future use of technology by salespeople will also impact client views of sales as a profession. Additional informationNotes on contributorsJon M. HawesJon M. Hawes (Ph.D., University of Arkansas), Professor of Marketing and Director of the Fisher Institute for Professional Selling, University of Akron, jhawes@uakron.edu.Anne K. RichAnne K. Rich (M.B.A. Candidate, University of Akron), Graduate Assistant, College of Business, University of Akron, anner7@hotmail.com.Scott M. WidmierScott M. Widmier (Ph.D., Arizona State University), Associate Professor of Marketing and International Business, College of Business,University of Akron, widmier@uakron.edu.
Large remnant polarization and excellent fatigue property of vanadium-doped SrBi4Ti4O15 thin films

Field: Materials Science (Physical Sciences)

We report the enhancement of electric and fatigue-endurance properties of vanadium-doped SrBi4Ti4O15 (SBTi) thin films deposited by a refined sol-gel method. The structures and surface morphologies of the films were characterized by x-ray diffraction, atomic force microscopy, and scanning electron microscopy. Their electric properties were investigated systematically. Compared to the undoped SBTi, V-doped SBTi [(SrBi3.99Ti3.97V0.03O15) (SBTV)] showed a larger remnant polarization (2Pr), lower coercive electric field, lower leakage current density, and a better fatigue resistance. The 2Pr of SBTV was 35.9μC∕cm2, which was much higher than that of SBTi (25.3μC∕cm2). Importantly, at a low frequency of 50kHz, the SBTV film showed no variation of Pnv and −Pnv after 2.2×109 switching cycles, suggesting excellent fatigue-endurance characteristics.
PREDICTING DEMAND FOR COTTON YARNS

Field: Decision Sciences (Social Sciences)

Predicting demand for fashion products is crucial for textile manufacturers. In an attempt to both avoid out-of-stocks and minimize holding costs, different forecasting techniques are used by production managers. Both linear and non-linear time-series analysis techniques are suitable options for forecasting purposes. However, demand for fashion products presents a number of particular characteristics such as short life-cycles, short selling seasons, high impulse purchasing, high volatility, low predictability, tremendous product variety and a high number of stock-keeping-units. In this paper, we focus on predicting demand for cotton yarns using a non-linear forecasting technique that has been fruitfully used in many areas, namely, random forests. To this end, we first identify a number of explanatory variables to be used as a key input to forecasting using random forests. We consider explanatory variables usually labeled either as causal variables, when some correlation is expected between them and the forecasted variable, or as time-series features, when extracted from time-related attributes such as seasonality. Next, we evaluate the predictive power of each variable by means of out-of-sample accuracy measurement. We experiment on a real data set from a textile company in Spain. The numerical results show that simple time-series features present more predictive ability than other more sophisticated explanatory variables.
Smart Agriculture Farming with Image Capturing Module

Field: Agricultural and Biological Sciences (Life Sciences)

Agriculture is an important factor for the wellbeing of a country. Though India is not the largest agriculture nation in the world, it contributes a considerable amount to the world's agriculture production. But due to various factors, the growth rate is dropping in recent times. This is one of the main reasons for the need of development in the field of agriculture. With the recent technological improvements, the field of agriculture can be automated with the help of Internet of Things (IoT), Wireless Sensor Networks (WSN), Cloud Computing & Big Data Analysis. The current agriculture network systems do not match with the speed and thus the storage capacity of various other factors also come into play. For this to improve, the researchers suggest for Agriculture as a Service (AaaS) model which is basically an Application as a Service. IoT helps to share the data which can be processed using Big Data techniques by storing into a cloud. This is the modern approach to the Agricultural Networking System problem which will improve the Quality of Service (QoS). This paper focuses on building such a system with the camera module. This module helps to capture the images which can be used to analyze the type of leaf and if it is affected by any disease. The information regarding the same can be sent to the users' mobile using the GSM technology.
Clinical efficacy of periodontal plastic surgery procedures: Consensus report of Group 2 of the 10th European Workshop on Periodontology

Field: Dentistry (Health Sciences)

AIM: The scope of the discussions of this consensus report was to assess the strength of the scientific evidence and make clinical and research recommendations for surgical interventions to cover exposed root surfaces and enhance soft tissues at implants. METHODS: Discussions were informed by three systematic reviews covering single recessions, multiple recessions and soft-tissue deficiencies at implants. The strength of the evidence was assessed using a modification in GRADE. The group also emphasized the need to report the experience of the surgeon and the performance of the control intervention (CONSORT guidelines for non-pharmacological treatment). RESULTS: A moderate strength of evidence supported the following statements for single (moderately deep, mostly maxillary) recessions without inter-dental attachment loss: (i) The addition of a connective tissue graft (CTG) improved outcomes of coronally advanced flaps (CAF). (ii) The addition of enamel matrix derivative (EMD) improved the outcomes of CAF. For multiple recessions, preliminary data indicate that flaps specifically designed to treat this condition are worthy of additional attention. Emerging data indicate that it is possible to obtain complete root coverage at sites with some inter-dental attachment loss. With regards to soft-tissue deficiencies at implants, several procedures are available, but great heterogeneity among studies does not allow drawing conclusions at this time. CONCLUSIONS: The group highlighted that periodontal plastic procedures are complex, technique-sensitive interventions that require advanced skills and expertise. At single recessions, the addition of autologous CTG or EMD under CAF improves complete root coverage and may be considered the procedure of choice at maxillary anterior and premolar teeth. The adjunctive benefit needs to be put in the context of increased morbidity of the donor area or increased cost. Additional research is needed to: (i) assess the role of alternatives to autologous soft-tissue grafting in combination with CAF; (ii) identify the optimal surgical design and the need for additional soft-tissue grafting (or alternatives) at multiple recessions, recessions with inter-dental attachment loss and soft-tissue deficiencies at implants.
DEPENDENCE BETWEEN THE WORD, THE PHRASEOLOGICAL UNIT AND THE «FREE» WORD-COMBINATION

Field: Arts and Humanities (Social Sciences)

The article under consideration dwells on the interrelationship between the word, its idiomatic equivalent and the word-combination. In actual speech words always come up in word-combinations. The lexical meaning of relatively ‘free’ word-combinations is the combined meaning of the component parts. But they are ‘free’ only in inverted commas because of the rules of lexical-phraseological combinability of words of this or that language. Substitutability of lexical components is the distinguishing feature of ‘free’ word-combinations in contrast to phraseological units. The latter, although consist of several words, semantically whole and convey a global meaning. Phraseological units are reproduced in speech.