jimnoneill/paper-to-field-training huggingface dataset:
Inevitable role of TGF-β1 in progression of nonalcoholic fatty liver disease

Field: Medicine (Health Sciences)

Nonalcoholic fatty liver disease (NAFLD) is a major health concern and the most commonly diagnosed chronic liver manifestation among 25% worldwide population. Obesity, insulin resistance, accumulation of toxic lipid free radicals, generation of oxidative stress, overconsumption of fat containing dietary meals and lack of exercise are the paramount factors accountable for the development of NAFLD. During NAFLD, increased oxidative stress and production of enormous number of toxic free radicals activates a number of pro-inflammatory and inflammatory pathways. TGF-β signaling mechanisms play a central role in maintaining the normal homeostasis of liver. TGF-β1, one of the three isoforms of TGF-β family has significant role in different stages of chronic liver conditions. TGF-β1 promotes HSC activation and extracellular matrix production (ECM), which further contributes in the progression of NAFLD. In this review, we outline the role of TGF-β1 in different phases of progressive NAFLD along with the signaling mechanism.
Dissimilar dosing with high-potency and low-potency neuroleptics

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The authors studied high-potency versus low-potency neuroleptic dosing practices for 110 Boston-area psychiatric inpatients and compared the findings with the dosing practices reported in surveys of nearly 16,000 Veterans Administration patients. Mean chlorpromazine equivalent doses for the most common agents correlated strongly in both samples. Although frequencies of lower doses of both types of agents were similar, doses of potent drugs above the daily equivalent of 1 g of chlorpromazine accounted for more than 40% of prescriptions. The mean chlorpromazine-equivalent dose of popular potent agents (haloperidol or fluphenazine) was 3.54 times as high as that of popular low-potency agents (chlorpromazine or thioridazine). Potent agents are commonly used in mania and schizophrenia, often in relatively high doses, which may carry an excess of risk over unproven added benefit.
Characterizing the human vaginal microbiome using high-throughput sequencing

Field: Medicine (Health Sciences)

Chloroquine continues to have a limited role in the chemoprophylaxis against malaria. Although periodic ophthalmologic examinations are recommended with weekly suppressive dosing, the occurrence of retinopathy associated with this regimen is unproven. Surveillance of career missionaries was conducted to explore the association between total body burden of chloroquine and the development of retinopathy. Five hundred eighty-eight missionaries, reflecting 6,250 person-years of chloroquine exposure were surveyed; 53 persons reflecting 560 person-years exposure with a median cumulative chloroquine dose in excess of 300 g were examined. Only one case of chloroquine-induced retinopathy was detected. This occurred in a missionary who had inappropriately taken chloroquine daily for at least six years as an anti-inflammatory agent for a connective tissue disorder. We also observed that expatriates often overused chloroquine because of apprehension about malaria and used the drug for unrelated conditions. Our results failed to demonstrate an association between a weekly chloroquine dosing regimen and drug-induced retinopathy.
In vitrotissue culture of dendrobium kontumense gagnep

Field: Agricultural and Biological Sciences (Life Sciences)

Tissue culture of Dendrobium kontumense Gagnep.was performed by culturing shoots (0.5 cm long) which were derived from protocorms on half-Murashige and Skoog ( 1/2 MS) and MS media. The average number of shoots was 1.40 shoot/explant, and the average length of the root was 2.86 cm when cultured on MS medium. When seedlings were transferred to culture on MSmedium supplemented with 0, 0.5, 1, 2, 3, 4 and 5 mg/L Naphthaleneacetic acid (NAA) in combination with 0, 0.5, 1, 2, 3, 4 and 5 mg/L N 6 -Benzyladenine (BA). The average number of shoots (2.80 shoot/explant), the high average length of the shoot (4.02 cm), the average number of roots (8.16 root/shoot) and the average length of the root (15.00 cm), were best achieved on MS medium supplemented with 0.5 mg/L NAA and 0.5 mg/L BA. They were transferred MS medium containing with 0, 5, 10, 15, 20 and 25% coconut water, the best shoot growth was observed with 15% coconut water. Upon subculture, the plantlets on MS medium supplemented with 0, 2, 4, 6, 8 and 10% ground banana, the shoots were formed at the best on MS medium with 6% ground banana. The plantlets transplanted to pots containing coconut hack under natural conditions displayed 90% survival.
Group and Family Day Care: A Comparative Assessment.

Field: Social Sciences (Social Sciences)

ME-$0.65 HC-T3.29 *Comparative Analysis; Cost Effectiveness; -Day Care Programs; *Day Care Services; *Family Environment; Group Activities; Mothers; Parent Attitudes; *Program Evaluation; Research; Staff Orientation; Surveys; Teacher Education; Teacher Qualifications; working Women The point is made that studies of day-care 1,se consistently confirm that the most common form of day care is in-home day care by a relative or another person. Group care as it now functions is most practical for a mother who works regular daytime hours and lives within manageable commuting distance of a center. The yearly costs per child reported for group care have ranged from a low of $400 to $1300 reported to a high of $2195 to $3895. Costs in family day care range from $114 to $1170 per year with an average of $1040Surveys of mothers' satisfaction with care all report fairly high satisfaction with their out-of-home arrangements. At present, there is little information on the effects of day care. The definition of quality care given in this study is a program which substitutes for a good home. L'indings of this study also include: (1) Size of day care centers is directly related to the quality of the program; (2) There did not appear to be any great differences in the quality of the programs related to auspices; (3) The quality of teacher perfcrmance is directly related to the type and amount of staff training; and (4) Staff of quality day care programs were judged to be more child-centered. (CK) U.S. DEPARTMENT OF HEALTH. EDUCATION.& WELFARE OFFICE OF EDUCATION THIS DOCUMENT HAS SEEN REPRODUCED EXACTLY AS RECEIVED FROM THE PERSON OR ORGANIZATION ORIG INATING IT POINTS OF VIEW OR OPINIONS STATED DO NOT NECESSARILY REPRESENT OFFICIAL OFFICE OE ECM CATION POSITION OR POLiCY GROUP AND FAMILY DAY CARE: A COMPARATIVE ASSESSNENT
Colicine types of Shigella sonnei isolated in Hong Kong

Field: Immunology and Microbiology (Life Sciences)

Two-hundred and twenty-five strains of Shigella sonnei isolated from sporadic cases of bacillary dysentery were subjected to colicine typing. The result showed that types 15 and 12 were the prevailing types in Hong Kong and two new types which did not fit in with the colicine patterns of the current types were observed. A marked increase in the numbers of strains concurrently resistant to chloramphenicol, tetracycline, and streptomycin occurred in recent years. However, there was no correlation between drug resistance or biochemical pattern and colicine types. Consistency of colicinogenicity was confirmed by the fact that even a rough variant of a smooth strain had not changed its colicine pattern.
Leakage Rate Models for Cracked Pipes

Field: Engineering (Physical Sciences)

Abstract This paper presents a leakage prediction study for Leak Before Break (LBB) assessments. The LBB concept has emerged as an essential tool for ensuring the safety of nuclear installations and pressurized piping systems. The approach is backed by accurate estimation of leakage rates from postulated cracks. In this study the methodology is based on the UK procedure for assessing structures containing defects (R6). The research is part of the ongoing in-house development of a software for LBB analyses and it aims to better understand and improve leak rate prediction methodologies for LBB assessments. The software is comprised of structural integrity modules and thermal hydraulic modules. This study presents the implementations of different coolant leak rates flow models, the Henry-Fauske model for flashing subcooled fluids and as single-phase Bernoulli model for lower temperatures. The thermal-hydraulics Henry Fauske model is evaluated against available experimental data and the differences are discussed. The Bernoulli based model is compared with another software. The implemented procedure is compared with two different software results for the structural modules. The structural calculations show coherence between the implemented procedure and the benchmark software that is based on the same methodology. In contrast the results are considerably different respect to another available software. The data show the significance and limitations of each model in various cases.
A Revision of A Published Inscription Found in Keraia

Field: Arts and Humanities (Social Sciences)

&amp;nbsp;G. H. R. Horsley ve S. Mitchell tarafından2000 yılında ilk kez yayımlanan Keraia’dan bir yazıt, 2014 yılındaki yüzeyaraştırmalarımız kapsamında yeniden görülerek revize edilmiştir. Kuzey Pisidiabölgesindeki Belören Köyü yakınında kurulu olan Keraia antik kentinde ele geçenbu belge, kentte şu ana kadar bulunmuş yalnızca iki yazıttan biri olması bakımındanönemlidir. Kentin doğu tarafındaki mezarlık alanı içerisinde yer alan birhereon kalıntısı arasındaki lahit kapağının bir bölümü bugün hala toprakaltında bulunmakta, ancak yazıtlı kısım kolayca okunabilmektedir. Yaptığımızayrıntılı otopside lahit ve harf ölçüleri yanında bazı ortographik hatalara darastlanmıştır. Bunun dışında yazıtın üstten bir satırının eksik kaydedildiğitespit edilmiştir. Dolayısıyla bu yayımda tespit ettiğimiz eksiklikler vehatalar giderilerek, heroon’u yaptıran kişinin tam adı Lucius FlaviusAurelianus Nestor olarak düzeltilmiştir.
Cooperative Multi-Agent Deep Reinforcement Learning for Adaptive Decentralized Emergency Voltage Control

Field: Computer Science (Physical Sciences)

Under voltage load shedding (UVLS) for power grid emergency control builds the last defensive perimeter to prevent cascade outages and blackouts in case of contingencies. This letter proposes a novel cooperative multi-agent deep reinforcement learning (MADRL)-based UVLS algorithm in an adaptive decentralized way. With well-designed input signals reflecting the voltage deviation, newly structured neural networks are developed as intelligent agents to obtain control actions and their probabilities to accommodate high uncertainties in volatile power system operations. Moreover, the interaction among the agents for coordinated control is implemented and refined by a state-of-the-art attention mechanism, which helps agents concentratively learn effective interacted information. The proposed method realizes decentralized coordinated control, adapting to extremely high uncertainties. Case studies on an IEEE benchmark system indicate the superior performance of the proposed algorithm.
Study of the Some Heavy Metals Residues in the Camel Meat in different regions of Kirkuk governorate during the spring and Summer Seasons

Field: Veterinary (Health Sciences)

Abstract For the purpose of searching for levels of some heavy contamination in muscle, liver and kidney meat for Camel in Kirkuk governorate in spring and summer seasons, samples were collected randomly from males (aged 4-5 years) from three reigns of Kirkuk governorate (Kirkuk center, Shwan and Laylan) During the March and April (spring season) and May and July months of (summer season) in 2020. There was a significant effect (p ≤ 0.05) on the factors (meat type, location and season) in the concentration of lead, Kidney meat in the Kirkuk center in the spring season recorded the highest concentration of lead and significant difference (8.008 ppm) The lowest concentration (2.211 ppm) was found in Liver in Spring. The highest concentration level of cadmium in muscle in summer season from Kirkuk center (4.191 ppm) in muscle, and lowers Concentration of cadmium (2.961 ppm) recorded in kidney from Laylan in summer season. The concentration of zinc in the Liver at the Kirkuk center in the summer season was the highest concentration (138.221 ppm), while the Kidney in the spring season from Kirkuk center recorded the lowest concentration (28.347 ppm). For Copper the liver in the Kirkuk center in the spring season had the highest concentration (26.754 ppm), while the Liver from the Kirkuk center at summer was recorded lowest concentration (4.663 ppm). For Cobalt, in spring season in Kirkuk, the Muscle recorded the highest concentration of cobalt (8.194 ppm) in summer, while the lowest concentration was recorded in Kidney the spring season from Kirkuk center (1.913 ppm). All types of metals recorded levels higher than the internationally accepted limits.
Photochemical synthesis of PT/PD alloy nanodots and graphene oxide/PT/PD hybrid catalyst

Field: Chemistry (Physical Sciences)

This report presents a novel method to synthesis of platinum and palladium alloy nano-dots via reducing mixed solution of Pt and Pd precursors by photo-irradiation in the presence of thiol molecules. The photosynthesis method is simple and efficient; as it could furnish a homogeneous reducing environment in solution without introducing in any additional reagent. The correlation of reduced Pd/Pt ratio versus different amounts of precursors added in mixed solution was investigated; and tunable Pd/Pt ratios from 1 to 6 were examined by Energy Dispersive X-ray Spectroscopy. Furthermore, self-assembly of Pd/Pt alloy nano-dots on graphene oxide, as a novel hybrid catalyst, through a secondary template of thiol was also discussed.
Resolvin D1 reduces the inflammatory response to rhinovirus infection in COPD bronchial epithelial cells

Field: Medicine (Health Sciences)

This in-vitro study showed that resolvin D1 reduced the pro-inflammatory response to rhinovirus infection in bronchial epithelial cells from COPD patients. Treatment with RvD1 significantly lowered IL-6 and IL-1β release without suppressing interferon production, viral load, or interferon-stimulated gene expression. These findings suggest that RvD1 can dampen airway inflammation while preserving antiviral immunity, supporting its potential role as a therapeutic strategy to aid recovery during COPD exacerbations.
Tumor-Specific Nascent Nine-Peptide-Epitopes Prediction and Bioinformatics Characterization in Human Colorectal Cancer

Field: Medicine (Health Sciences)

Background/Aims: Neoantigens are peptides produced by translation of mutant exons and existed in tumor tissues instead of normal tissues, thus, we desired to investigate the antigenic peptide epitopes of cancerspecific neoantigen, to detect the affinity of the nonapeptide with the corresponding Human Leukocyte Antigen I (HLA I) allele molecule, in order to understand the relationship of mutant exon genes of Colorectal Cancer (CRC) patients and the drive genes that are currently known for tumorigenesis of CRC. Methods: The next generation sequencing (NGS) method was used to detect the whole genome sequence and HLA I allele types of tumor tissues and adjacent tissues of 5 CRC patients. pVAC-Seq was applied to identify the nascent nonapeptides generated from exon mutations. The affinity of polypeptides with respective HLA I molecules in CRC was calculated by using NETMHC 4.0 Server. The molecular localization, molecular function, and signal pathways of mutant genes in 5 CRC patients were performed by FunRich 3.1.3 software. The TIMER website was applied to predict the analysis of intratumoral immune cell infiltration associated with the gene mutations in 5 CRC patients. Results: Fifty-six tumor-specific neo-nonapeptides were predicted from 54 different exon gene mutations. The 56 tumor new nonapeptide sequences were different from the shared motif of the HLA I allele. We explored that the tumor-specific nascent nonapeptide mainly bound to HLA-A.02*03, HLA-B.58*01 and HLA-B.11*01, and the affinity analysis results suggested that 14 of the nonapeptides had strong binding force, 20 nonapeptides had weak binding force, and 22 nonapeptides had no binding force. 54 mutant exons of 5 CRC patients were chiefly located in Leading edge membrane, Fanconi anaemia nuclear complex, and Azurophil granule. The molecular functions of these genes were involved in DNA-directed DNA polymerase activity, Vitamin or cofactor transporter activity, and Receptor signaling protein tyrosine kinase activity. 54 gene mutations had key roles in Translesion synthesis by Pol zeta, Translesion synthesis by DNA polymerases bypassing lesion on DNA template, and DNA Damage Bypass. We found that the mutant FMN2 had more infiltration of CD8+ T cells in the tumor than the wild type, and the mutant ZNF717 had more infiltration of CD8+ T cells and neutrophils in the tumor than the wild type, the difference was statistically significant. Conclusion: This study provides a preliminary result to illustrate that the prediction and bioinformatics feature of tumor-specific new nine-peptide-epitopes in CRC. It is hoped that the cancer-specific neoantigen will be used for adjuvant immunotherapy after radical surgery of colorectal cancer, and the mutant genes of CRC can also be used as landmarks for postoperative recurrence and metastasis of colorectal cancer.
EVALUATION OF EIGHT SELECTED ETHIOPIAN INDIGENOUS FORAGE SPECIES FOR THEIR NUTRITIVE VALUES

Field: Agricultural and Biological Sciences (Life Sciences)

Indigenous forage species contribute to the largest proportion of the livestock feed in Ethiopia. However, their potential as livestock feed has often been overlooked. Therefore, the present study aims to evaluate the nutritive value of eight selected Ethiopian indigenous forage species for their nutritive value. The experiment was undertaken using a complete randomized design at Wondogent medicinal field gene bank. Results showed that Pennisetum pedicellatum (91.72%) and Medicago polymorpha (91.68%) had significantly (P<0.001) higher dry matter (DM) contents than other forage species with the exception of Medicago sativa. Ash content (15.46%) of Pennisetum pedicellatum was the highest (P<0.001) of all the species except Medicago sativa, while the highest organic matter (OM) content (90.80%) was record from Medicago polymorpha. Vicia species had (P<0.05) higher crude protein (CP) concentration (19.03%) than that of Medicago sativa (13.57%), Medicago lupulina (12.36%), Medicago polymorpha (11.57%) and Pennisetum pedicellatum (7.47%). The neutral detergent fiber (NDF) was higher (P<0.05) in Pennisetum pedicellatum (76.23%), whereas Sesbania sesban had the lowest (P<0.05) NDF value except Sebania grandiflora. Acid detergent fiber (ADF) was significantly higher in Medicago lupulina (53.80%) while Sesbania sesban had lower contents of both ADF (39.42%) and ADF (34.04%). However, there was no significant variation in terms of acid detergent lignin (ADL), metabolizable energy (ME) and In vitro digestible organic matter (IVDOM) among these forge species. Generally, with the exception of Pennisetum pedicellatum, the moderate CP, and lower fiber content of these forage species suggest that they have high nutritional value that deserves special attention.
Ion-flux characteristics during low-temperature (300 °C) deposition of thermochromic VO2 films using controlled reactive HiPIMS

Field: Materials Science (Physical Sciences)

Charakteristiky iontových toků na pozici substrátu a odpovídající výbojové charakteristiky byly vyšetřovány pro řízené nízkoteplotní (300 °C) reaktivní HiPIMS depozice termochromických VO2 vrstev na konvenční sodnovápenaté skleněné substráty bez přivedeného předpětí na substrát a bez jakékoliv mezivrstvy. Bylo ukázáno, že fázové složení vrstev korelovalo s iontovým podílem (V+ + V2+) a s poměrem iontů (V+ + V2+):(2O2+ + O+) v celkovém iontovém toku na substrát. Nastavení množství kyslíku v plynné směsi umožnilo řídit nejen fázové složení vrstev, ale také jejich krystalinitu. Bylo zjištěno, že vhodné složení celkového iontového toku a vysoké energie iontů (až 50 eV vůči zemi) podpořily krystalizaci termochromické fáze ve VO2 vrstvách. Dosáhli jsme vysoké modulace transmitance pro vlnovou délku 2500 nm (mezi 51 % a 8 %) a elektrické rezistivity (změna 350×) VO2 vrstvy o tloušťce 88 nm.
Intrathecal Morphine Enhances Postoperative Analgesia and Recovery in Robotic-Assisted Laparoscopic Partial Nephrectomy: A Retrospective Study of 272 Patients

Field: Medicine (Health Sciences)

BACKGROUND Robot-assisted laparoscopic partial nephrectomy (RAPN) has been increasingly used for treating renal tumors due to its advantages over other approaches. However, RAPN can induce acute incisional, peritoneal, visceral, and referred pain. Therefore, acute pain control in robotic surgery is a concern. This retrospective study aimed to evaluate the efficacy of intrathecal morphine (ITM) for postoperative analgesia and recovery after RAPN. MATERIAL AND METHODS We retrospectively investigated consecutive patients who underwent RAPN at our institute between 2020 and 2021. Among the 272 patients who met the inclusion criteria, 135 patients were administered 200 µg of ITM preoperatively (ITM group), while 137 patients were not (control group). Postoperative pain assessments using the numeric rating scale (NRS), opioid requirements, and recovery profiles during the first postoperative 24 h were compared between the 2 groups. RESULTS As the primary endpoint, the incidence of moderate-to-severe pain (24-h average NRS pain score ≥4) was significantly lower in the ITM group than in the control group (36.3% vs 61.3%, P<0.001). Pain scores and cumulative opioid requirements were also significantly lower in the ITM group for all assessments (P<0.001). Moreover, the ITM group had a higher score on the Quality of Recovery-15 questionnaire on the first postoperative day (129 vs 120, P=0.003) despite an increased rate of postoperative nausea/vomiting (27.4% vs 13.1%, P=0.003). CONCLUSIONS Our findings indicate that ITM provided superior pain control during the early period following RAPN, with reduced postoperative opioid requirements. Moreover, ITM improved patient satisfaction with recovery.
Connective-Tissue Glycoconjugates of Bovine Tendon and Skin

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Conference Article| April 01 1977 Connective-Tissue Glycoconjugates of Bovine Tendon and Skin JOHN C. ANDERSON; JOHN C. ANDERSON *Departments of Medical Biochemistry, Medical School, University of Manchester, Manchester M13 9PT, U.K. Search for other works by this author on: This Site PubMed Google Scholar RHONA I. LABEDZ; RHONA I. LABEDZ *Departments of Medical Biochemistry, Medical School, University of Manchester, Manchester M13 9PT, U.K. Search for other works by this author on: This Site PubMed Google Scholar PAUL E. BRENCHLEY PAUL E. BRENCHLEY †Departments of Immunology, Medical School, University of Manchester, Manchester M13 9PT, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1977) 5 (2): 431–433. https://doi.org/10.1042/bst0050431 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation JOHN C. ANDERSON, RHONA I. LABEDZ, PAUL E. BRENCHLEY; Connective-Tissue Glycoconjugates of Bovine Tendon and Skin. Biochem Soc Trans 1 April 1977; 5 (2): 431–433. doi: https://doi.org/10.1042/bst0050431 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1977 Biochemical Society1977 Article PDF first page preview Close Modal You do not currently have access to this content.