jimnoneill/paper-to-field-training huggingface dataset:
The Enforcement of Basic Rights and Freedoms and the State of Judicial Activism in Tanzania

Field: Social Sciences (Social Sciences)

Abstract This article re-assesses the means available for the effective enforcement of human rights in Tanzania based on the valid assumption that the proclamation of human rights in legal instruments, be they at the domestic or international level, is meaningless without the entrenchment of effective enforcement procedures. Particular attention is directed towards the re-examination of the capacity and ability of the courts to meet the challenges posed by human rights and political discourses in their ongoing transformation. The issue is whether they can be said to be adequately providing effective avenues for the promotion, protection and enforcement of human rights.
Safety and Pharmacokinetics of Intravenous 10-1074 and VRC01LS in Young Children

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background: Broadly neutralizing monoclonal antibodies (bNAbs) suppress HIV-1 RNA and may deplete residual viral reservoirs. We evaluated the safety and pharmacokinetics (PK) of dual intravenous VRC01LS and 10-1074 in very early-treated children with HIV-1 on suppressive antiretroviral treatment (ART). Setting: Botswana. Methods: Children with HIV-1 (median age 3.1 years) on ART from <7 days old were enrolled. In phase A, 6 children received 10-1074 (30 mg/kg at day 0, 28, and 56) and 6 children received VRC01LS (30 mg/kg at day 0, 10 mg/kg at days 28 and 56) by intravenous infusion. In phase B, 6 children received the 2 bNAbs combined (with higher VRC01LS maintenance dose, 15 mg/kg) every 4 weeks for 32 weeks with PK evaluations over 8 weeks. Population PK models were developed to predict steady-state concentrations. Results: BNAb infusions were well tolerated. There were no infusion reactions nor any bNAb-related grade 3 or 4 events. The median (range) first dose Cmax and trough (day 28) combined from both phases were 1405 (876–1999) μg/mL and 133 (84–319) μg/mL for 10-1074 and 776 (559–846) μg/mL and 230 (158–294) μg/mL for VRC01LS. No large differences in bNAb clearances were observed when given in combination. The estimated VRC01LS half-life was shorter than in adults. Predicted steady-state troughs [median (90% prediction interval)] were 261 (95–565) and 266 (191–366) μg/mL for 10-1074 and VRC01LS, respectively, when given in combination. Conclusions: 10-1074 and VRC01LS were safe and well-tolerated among children receiving ART. Troughs exceeded minimal targets with every 4-week administration of 10-1074 at 30 mg/kg and VRC01LS at 15 mg/kg.
Production of Mycelia and Water Soluble Polysaccharides from Submerged Culture of Ganoderma applanatum Using Different Types of Bioreactor

Field: Chemical Engineering (Physical Sciences)

잔나비불로초 배양에 적합한 생물반응기를 선발하기 위하여 4종류의 생물반응기 형태별 균사체 생장특성과 다당체 생산량을 비교하였다. 균사체 생산량은 기포통기형 생물반응기($7\;g/{\ell}$) > 풍선형 생물반응기($6.2\;g/{\ell}$) > 교반형 생물반응기($6\;g/{\ell}$) > 컬럼형 생물반응기($5\;g/{\ell}$) 순으로 나타났으며, 기포통기형 생물반응기에서 가장 높은 세포외 다당체($1\;g/{\ell}$)와 세포 내다당체(2.7%)를 생산하여 기포통기형 생물반응기가 잔나비불로초 균사체 배양에 가장 적합한 것으로 나타났다. 세포외 다당체의 분자량도 생물반응기의 형태별에 따라 다르게 나타났으며, 기포통기형 생물반응기에서 가장 높은 분자량을 나타냈다. 기포통기형 생물반응기에서의 적정한 공기공급율은 0.05부터 0.1 vvm 사이로 나타났다. 특히 잔나비불로초 균사체는 배양하면서 배지의 점도가 높아져 점차 공기 공급량을 높여 주는 것이 좋은 것으로 판단된다. In order to select a suitable bioreactor type for the submerged cultivation of Ganoderma applanatum, both growth characteristics and polysaccharides production were compared among four different types of bioreactor. These include an external-loop type air-lift bioreactor (ETAB), a balloon type air bubble bioreactor (BTBB), a column type air bubble bioreactor (CTBB) and a stirrer type bioreactor (STB). The mycelial biomass produced from the reactors were in decreasing order: ETAB ($7\;g/{\ell}$) > BTBB ($6.2\;g/{\ell}$) > STB ($6\;g/{\ell}$) > CTBB ($5\;g/{\ell}$). Maximal soluble exopolysaccharides ($1\;g/{\ell}$) and endopolysaccharides (2.7%) were also obtained from ETAB. Thus, the ETAB was most suitable for submerged culture of G applanatum mycelium. Based on the results, ETAB was chosen for further detailed study. The most effective aeration rate for the mycelial growth in ETAB ranged from 0.05 to 0.1 vvm. For the maximal production, the mycelium at the initial growth stage needed low aeration rate to reduce cell damages by fluid flow. However, as the mycelia grew, the culture became viscous and thus needed higher aeration. The molecular weight of exopolysaccharides obtained from the culture grown in ETAB was higher than that from the culture grown in other bioreactors.
Best Paper Selection

Field: Health Professions (Health Sciences)

Daniulaityte R, Chen L, Lamy FR, Carlson RG, Thirunarayan K, Sheth A. “When ‘Bad’ is ‘Good’”: Identifying Personal Communication and Sentiment in Drug-Related Tweets. JMIR Public Health Surveill 2016 Oct 24;2(2):e162 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099500/ Freedman RA, Viswanath K, Vaz-Luis I, Keating NL. Learning from social media: utilizing advanced data extraction techniques to understand barriers to breast cancer treatment. Breast Cancer Res Treat 2016 Jul;158(2):395-405 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537590/ Hawkins JB, Brownstein JS, Tuli G, Runels T, Broecker K, Nsoesie EO, McIver DJ, Rozenblum R, Wright A, Bourgeois FT, Greaves F. Measuring patient-perceived quality of care in US hospitals using Twitter. BMJ Qual Saf 2016 Jun;25(6):404-13 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878682/ Kondylakis H, Koumakis L, Hänold S, Nwankwo I, Forgó N, Marias K, Tsiknakis M, Graf N. Donor’s support tool: Enabling informed secondary use of patient’s biomaterial and personal data. Int J Med Inform 2017 Jan;97:282-92 https://linkinghub.elsevier.com/retrieve/pii/S1386-5056(16)30234-9 Massey PM, Leader A, Yom-Tov E, Budenz A, Fisher K, Klassen AC. Applying Multiple Data Collection Tools to Quantify Human Papillomavirus Vaccine Communication on Twitter. J Med Internet Res 2016 Dec 5;18(12):e318 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168526/
Maximal Sylow Subgroups of a Given Group

Field: Mathematics (Physical Sciences)

Gene expression variation is shaped by both genetic and environmental effects, yet these two factors are rarely considered together in the context of adaptive evolution. We studied environmental influences on gene regulatory evolution in ...Changes in gene expression are thought to play a major role in adaptive evolution. While it is known that gene expression is highly sensitive to the environment, very few studies have determined the influence of genetic and environmental effects on ...
The Preparation of N-Ethylglycocyamine. Double Salt Formation Between Guanidines and Amino Acids1

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of N-Ethylglycocyamine. Double Salt Formation Between Guanidines and Amino Acids1MARVIN D. ARMSTRONGCite this: J. Org. Chem. 1956, 21, 5, 503–505Publication Date (Print):May 1, 1956Publication History Published online1 May 2002Published inissue 1 May 1956https://pubs.acs.org/doi/10.1021/jo01111a004https://doi.org/10.1021/jo01111a004research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Federal Case for Women’s Suffrage

Field: Social Sciences (Social Sciences)

Abstract In 1911, following the loss of her mother, Crystal Eastman married Wallace “Bennie” Benedict and moved to his home state of Wisconsin. Unable to find work as a lawyer, she accepted a job as campaign manager for the state’s suffrage drive. After a vicious battle, including opposition from the powerful brewing industry and elected officials, the measure lost two to one. Eastman returned to the Village in 1913, with Bennie in tow. He would soon initiate an affair, inciting a divorce that was finalized in 1916. Meanwhile, Eastman had united with Alice Paul and Lucy Burns, organizing the younger, more confrontational suffrage women to found the militant wing of the suffrage movement that became the National Woman’s Party. The group’s actions inside and outside the US Congress, including spectacular demonstrations and White House picketing to target the “party in power”—Woodrow Wilson and the Democrats—would finally leverage votes for women.
“I have never met the normal woman”: Stella Browne and the politics of womanhood

Field: Arts and Humanities (Social Sciences)

Abstract F. W. Stella Browne (1880–1995) and her views on female sexuality have been much discussed of recent years. These discussions have tended to rely on a limited number of her copious (if often hard-to-find) writings, and have also failed to take into account where Stella, as an individual woman, was coming from. In the light of ongoing researches into her life and career, this article locates her writings in her life of activism in a wide variety of causes. It argues that her opinions about women's needs do not conform to a simplistic model of a ‘New’ feminism of difference, and that her relationship to the thought of contemporary male sexologists has been presented in a one-dimensional and misleading way. Her tripartite commitment to feminism, socialism, and individualism is illustrated, drawing on a wide range of her writings and statements between 1912 and 1937. In her crusade to celebrate and liberate the “variety and variability of women” Stella sought constantly to overthrow concepts of a monolithic female nature as well as to reject the Double Moral Standard: ‘normality’ to her was an instrument for the oppression of women. Consideration is also given to the wider influence of her ideas.
Therapeutic time window for angiotensin‐(1–7) in acute lung injury

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background and Purpose There is presently no proven pharmacological therapy for the acute respiratory distress syndrome. Recently, we and others discovered that the heptapeptide angiotensin‐(1–7) [Ang‐(1–7)] shows significant beneficial effects in preclinical models of acute lung injury (ALI). Here, we aimed to identify the best time window for Ang‐(1–7) administration to protect rats from oleic acid (OA) induced ALI. Experimental Approach The effects of i.v. infused Ang‐(1–7) were examined over four different time windows before or after induction of ALI in male Sprague–Dawley rats. Haemodynamic effects were continuously monitored, and loss of barrier function, inflammation and lung peptidase activities were measured as experimental endpoints. Key Results Ang‐(1–7) infusion provided the best protection against experimental ALI when administered by continuous infusion starting immediately after 30 min OA infusion till the end of the experiment (30–240 min). Both pretreatment (−60 to 0 min before OA) and short‐term therapy (30–90 min) also had beneficial effects although less pronounced than the effects achieved with the optimal therapy window. Starting infusion of Ang‐(1–7) 60 min after the end of OA treatment (90–240 min) did not protect barrier function or haemodynamics but still reduced myeloperoxidase activity and increased ACE2/ACE activity ratio respectively. Conclusions and Implications Our findings indicate that early initiation of therapy after ALI and continuous drug delivery are most beneficial for optimal therapeutic efficiency of Ang‐(1–7) treatment in experimental ALI and, presumably accordingly, in clinical acute respiratory distress syndrome.
Alcohol Consumption in Demographic Subpopulations: An Epidemiologic Overview

Field: Medicine (Health Sciences)

Alcohol consumption is common across subpopulations in the United States. However, the health burden associated with alcohol consumption varies across groups, including those defined by demographic characteristics such as age, race/ ethnicity, and gender. Large national surveys, such as the National Epidemiologic Survey on Alcohol and Related Conditions and the National Survey on Drug Use and Health, found that young adults ages 18-25 were at particularly high risk of alcohol use disorder and unintentional injury caused by drinking. These surveys furthermore identified significant variability in alcohol consumption and its consequences among racial/ethnic groups. White respondents reported the highest prevalence of current alcohol consumption, whereas alcohol abuse and dependence were most prevalent among Native Americans. Native Americans and Blacks also were most vulnerable to alcohol-related health consequences. Even within ethnic groups, there was variability between and among different subpopulations. With respect to gender, men reported more alcohol consumption and binge drinking than women, especially in older cohorts. Men also were at greater risk of alcohol abuse and dependence, liver cirrhosis, homicide after alcohol consumption, and drinking and driving. Systematic identification and measurement of the variability across demographics will guide prevention and intervention efforts, as well as future research.
Involutions of Azumaya Algebras

Field: Mathematics (Physical Sciences)

We consider the general circumstance of an Azumaya algebra $A$ of degree $n$ over a locally ringed topos $(\mathbf{X}, \mathcal O_\mathbf{X})$ where the latter carries a (possibly trivial) involution, denoted $\lambda$. This generalizes the usual notion of involutions of Azumaya algebras over schemes with involution, which in turn generalizes the notion of involutions of central simple algebras. We provide a criterion to determine whether two Azumaya algebras with involutions extending $\lambda$ are locally isomorphic, describe the equivalence classes obtained by this relation, and settle the question of when an Azumaya algebra $A$ is Brauer equivalent to an algebra carrying an involution extending $\lambda$, by giving a cohomological condition. We remark that these results are novel even in the case of schemes, since we allow ramified, non-trivial involutions of the base object. We observe that, if the cohomological condition is satisfied, then $A$ is Brauer equivalent to an Azumaya algebra of degree $2n$ carrying an involution. By comparison with the case of topological spaces, we show that the integer $2n$ is minimal, even in the case of a nonsingular affine variety $X$ with a fixed-point free involution. As an incidental step, we show that if $R$ is a commutative ring with involution for which the fixed ring $S$ is local, then either $R$ is local or $R/S$ is a quadratic \'etale extension of rings.
Improvement of time in range and glucose management indicator in Type 1 and Type 2 Diabetes Mellitus patients after introduction of continuous Glucose monitoring in internal medicine residency clinic

Field: Medicine (Health Sciences)

Continuous glucose monitoring (CGM)-derived time in range (TIR) correlates with Glucose management indicator(GMI) which correlates with hemoglobin A1c (HbA1c) among patients with type 1 and type 2 diabetes mellitus. Compare to HbA1c it has better correlation with glucose control, because HbA1c can be influenced by conditions like anemia, Chronic kidney disease, Cirrhosis of the liver etc. With our current project we wanted to introduce CGM not in specialized endocrine clinic, but in Internal medicine Residency clinic. The CGM team had 12 Internal Medicine and Transitional year Residents who were functioning under the supervision of Board Certified Endocrinologist who was a member of the clinic also. Twenty Five patients -85% with type 2 DM and 15% with type 1 DM on multiple injections of Insulin per day-3-4, self-monitored their blood Glucose(SMBG). They were given CGM- Dexcom G6 in the clinic. In the first 2- weeks after the switch the TIR of the blood glucose of the patients-70-180 mg/dl was 18%. Their average blood glucose was 286 mg/dl, GMI was 11.21%. During then first 2- weeks after initiation of CGM the patients were educated in length by our CGM team about their diet, physical activity, how to adjust their Insulin based on their blood glucose levels as well as how to treat the hypoglycemia. Members of the CGM team were contacting the patients twice a week to adjust patients treatment with Insulin and other per oral antidiabetic medications and or injectable – GLP1-RAG if needed after consultation with the Endocrinologist in the clinic based on the shared information between the clinic and the patients. Once a month the patients were seen in the clinic by member of the CGM team as well. The patients were followed for 2- years. After 3- months on CGM and followed for the 2 years thereafter the patients TIR improved from 18 % to 74%, GMI decreased from 11.21% to 7.04% and the average blood glucose decreased from 286 mg/dl to 158 mg/dl. There was also significant reduction of the hypoglycemia. Twenty percent of the patients were able to discontinue their Insulin and be treated only with oral antidiabetic medications plus/minus GLP1-RAG and have GMI less than 7%. We have showed that targeted TIR – above 70% which has been associated recently with diabetic micro and macrovascular complications in diabetic patients can be achieved not only in specialized endocrine clinics , but in Internal Medicine residency clinic and can be adopted by other Internal Medicine Residency programs in USA.
CD44 Regulates Vascular Gene Expression in a Proatherogenic Environment

Field: Medicine (Health Sciences)

Objective— To identify early changes in vascular gene expression mediated by CD44 that promote atherosclerotic disease in apolipoprotein E (apoE)–deficient (apoE−/−) mice. Methods and Results— We demonstrate that CD44 is upregulated and functionally activated in aortic arch in the atherogenic environment of apoE−/− mice relative to wild-type (C57BL/6) controls. Moreover, CD44 activation even in apoE−/− mice is selective to lesion-prone regions because neither the thoracic aorta from apoE−/− mice nor the aortic arch of C57BL/6 mice exhibited upregulation of CD44 compared with thoracic aorta of CD57BL/6 mice. Consistent with these observations, gene expression profiling using cDNA microarrays and quantitative polymerase chain reaction revealed that ≈155 of 19 200 genes analyzed were differentially regulated in the aortic arch, but not in the thoracic aorta, in apoE−/− CD44−/− mice compared with apoE−/− CD44+/+ mice. However, these genes were not regulated by CD44 in the context of a C57BL/6 background, illustrating the selective impact of CD44 on gene expression in a proatherogenic environment. The patterns of differential gene expression implicate CD44 in focal adhesion formation, extracellular matrix deposition, and angiogenesis, processes critical to atherosclerosis. Conclusions— CD44 is an early mediator of atherogenesis by virtue of its ability to regulate vascular gene expression in response to a proatherogenic environment.
Raman and resonance Raman studies of tetraphosphorus triselenide

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRaman and resonance Raman studies of tetraphosphorus triselenideGary R. Burns, Joanne R. Rollo, and Robin J. H. ClarkCite this: Inorg. Chem. 1986, 25, 8, 1145–1149Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/ic00228a017https://doi.org/10.1021/ic00228a017research-articleACS PublicationsRequest reuse permissionsArticle Views87Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
"BM180": a novel basement membrane protein with a role in stimulus-secretion coupling by lacrimal acinar cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Regulated secretion requires the developmental coupling of neuronal or hormonal stimuli to an exocytotic response, a multistep pathway whose appearance may be linked with cellular adhesion to the newly formed exocrine cell basement membrane. We screened for adhesion-associated coupling activity using lacrimal acinar cells and have identified “BM180”, a novel basement membrane protein enriched in guanidine HCl extracts of lacrimal and parotid exocrine secretory glands. BM180 resides primarily in a previously inexamined lower molecular-mass basement membrane peak (peak 2) that contains cell adhesion activity inhibitable with the anti-BM180 monoclonal antibody 3E12. Removal of peak 2 by gel filtration or preincubation of basement membrane with 3E12 decreased regulated peroxidase secretion by one-half without affecting constitutive secretion or the amount of cellular peroxidase available for release. Adding back peak 2 restored regulated secretion in a dose-dependent and 3E12-inhibitable manner and suggested a synergistic relationship between BM180 and laminin 1. BM180 has a mobility of 180 and 60 kDa in the absence or presence of dithiothreitol, respectively, and shows no immunological identity by competitive enzyme-linked immunosorbent assay with laminin 1, collagen IV, entactin, fibronectin, BM-40, perlecan, or vitronectin. We propose that BM180 is an important resident of certain glandular basement membranes where it interacts with the cell surface, thereby possibly signaling the appearance of a transducing element in the stimulus-secretion coupling pathway.