jimnoneill/paper-to-field-training huggingface dataset:
A Dose-Dependent Improvement in Exercise Tolerance in Patients With Stable Angina Treated With Mildronate: A Clinical Trial “MILSS I”

Field: Medicine (Health Sciences)

Objective. To assess the efficacy of various doses of Mildronate in combination with standard therapy for the exercise tolerance of patients with stable angina pectoris. The primary efficacy variable was the change in exercise time in bicycle ergometry from the baseline to 12 weeks of treatment. The secondary endpoints were the changes in maximum achieved load and time to the onset of angina from the baseline to week 12. Material and Methods. A total of 512 patients with chronic coronary heart disease who had ischemia as the limiting factor in the exercise test from 72 study centers in 4 countries were enrolled in this prospective, randomized, double-blind, placebo controlled phase 2 study. The patients were assigned to either 4 groups receiving standard therapy plus Mildronate at different daily doses or 1 group receiving standard therapy plus placebo. Results. The mean change in the total exercise time in the mildronate 100 mg and mildronate 300 mg groups was –2.12±108.45 and 11.48±62.03 seconds, respectively. The mean change for the placebo group was –7.10±81.78 seconds. The difference between Mildronate 100 mg and 300 mg and placebo groups was not significant. Patients in the Mildronate 1000 mg group showed a remarkable increase in the mean change in the total exercise time (35.18±53.29 seconds, P=0.002). Mildronate at a dose of 3000 mg caused a smaller increase as compared with a dose of 1000 mg. Similar changes in the secondary end parameters were observed. Conclusion. The most effective dose of Mildronate in combination with standard therapy was found to be 500 mg twice a day.
Mitigating Land Corruption through Computerisation of Statutory Land Governance Activities: Evidence from DRC, Tanzania and Zambia

Field: Social Sciences (Social Sciences)

This study was on mitigating land corruption through computerisation of land governance activities that include land use planning, cadastral surveying, servicing of land, land allocation, land registration and titling and land development. Using evidence from Lubumbashi (Democratic Republic of the Congo), Dar es Salaam (Tanzania) and Kitwe (Zambia), the study used both primary and secondary data to conclude that despite computerisation of land governance activities in Tanzania and Zambia, corruption still persists. On the other hand, land governance activities in Lubumbashi (Democratic Republic of the Congo) were still paper based and this made the activities highly susceptible to corruption. Causes of corruption identified were low salaries for employees in public land institutions, delay in payment of salaries, lack of monitoring in the services provided, cumbersome procedures, and lack of transparency. In view of these, it is recommended that the respective governments should work on reducing corruption through increasing salaries for employees in land institutions, pay salaries on time, effective monitoring in the services provided, streamlining procedures and ensure transparency.
Quantitative structure activity relationship studies of androgen receptor binding affinity of endocrine disruptor chemicals with index of ideality of correlation, their molecular docking, molecular dynamics and ADME studies

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Endocrine disrupter chemicals (EDCs) are both natural and man-made chemicals that mimic, block or interfere with human hormonal system. In the present manuscript, QSAR modeling was performed for the androgen disruptors that interfere with biosynthesis, metabolism or action of androgens that causes adverse effects on male reproductive system. A set of 96 EDCs that exhibited affinity towards androgen receptors (Log RBA) in rats were employed for carrying out QSAR studies using Hybrid descriptors (combination of HFG and SMILES) through Monte Carlo Optimization. Using index of ideality of correlation (TF2), five splits were formed and predictability of five models resulting from these splits was assessed by various validation parameters. Models resulted from first split was the top most one with R2validation = 0.7878. Structural attributes responsible for change in endpoint were studied by employing correlation weights of structural attributes. In order to further validate the model, new EDCs were designed using these attributes. In silico molecular modelling studies were performed to assess the detailed interactions with the receptor. The binding energies of all the designed compounds were observed to be better than lead and are in the range of −10.46 to −14.80. Molecular dynamics simulation of 100 ns was performed for ED01 and NED05. The results revealed that the protein-ligand complex bearing NED05 was more stable than lead ED01 exhibiting better interactions with the receptor. Further, in an attempt to assess their metabolism, ADME studies were evaluated using SwissADME. The developed model enables to predict the characteristics of designed compounds in an authentic way. Communicated by Ramaswamy H. Sarma
Robust design based on synthetic judgment for the luffing mechanism of truck-mounted crane

Field: Engineering (Physical Sciences)

The performance index is determined by structure and kinetic analysis for the luffing mechanism of truck-mounted crane,and a mathematical model for robust design is established.Specific to restraint multi-performance of Robust design of the luffing mechanism,by adopting synthetic judgment the robust design for the luffing mechanism of truck-mounted crane is conducted based on loss model method to obtain optimal design parameter for impacting the performance of the mechanism.Therefore,the max.thrust of the luffing cylinder is decreased to the minimum with little fluctuation ratio of the thrust and stable piston.Meanwhile it is rectified through experiment the correct and practical value of the method,which pro-vide reference for the application of robust design method in dealing with multi-performance index.
Wind turbine generation system with simple rectifier using MERS in current link topology wind farm

Field: Energy (Physical Sciences)

Multipole (gearless) PMSG is one of the most promissing wind turbine generation system for multi-megawatt range, because of its high efficiency and low maintenance advantage. In this digest, the current link topology based wind turbine generation system with simple diode rectifier using MERS (Magnetic Energy Recovery Switch) is proposed. Although diode rectifier is more simple, more robust and inexpensive than active rectifier, the diode rectifier alone is incapable to control the reacvtive power. Thus in this digest the wind energy conversion system with the diode rectifier using MERS is proposed. MERS here functions as a variable capacitor and enables the torque of the generator to be controllable, so that maximum power tracking operation corresponding wind speed change is realized by MERS control. This proposed system possesses several prominent advantages which are presented below.
VALIDATION AND WEIGHTING OF CENSUS BASED DEPRIVATION INDICES

Field: Social Sciences (Social Sciences)

The construction of Census based deprivation indices is one of the most economically important uses of social statistics since they form a key element in the allocation of both local government and health resources. However, none of the questions in the 1991 Census was specifically designed to measure either poverty or deprivation. Therefore, any Census based index must be comprised of variables that are, at best, proxy indicators of deprivation rather than direct measures. It is, therefore, unsurprising that a bewildering array of indices has been proposed, using different combinations of variables and different statistical methods.
Reviews of the Literature

Field: Social Sciences (Social Sciences)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Reviews of the Literature. Human Organization 1 March 1952; 11 (1): 41–44. doi: https://doi.org/10.17730/humo.11.1.h22w421173n54067 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search
Modeling and Analysis of Switched-Capacitor Converters as a Multi-port Network for Covert Communication

Field: Engineering (Physical Sciences)

Switched-capacitor (SC) DC-DC voltage converters are widely used in power delivery and management of modern integrated circuits. Connected to a common supply voltage, SC converters exhibit cross-regulation/coupling effects among loads connected to different SC converter stages due to the shared components such as switches, capacitors, and parasitic elements. The coupling effects between SC converter stages can potentially be used in covert communication, where two or more entities (e.g., loads) illegitimately establish a communication channel to exchange malicious information stealthily. To qualitatively analyze the coupling effects, a novel modeling technique is proposed based on the multi-port network theory. The fast and slow switching limit (FSL and SSL) equivalent resistance concepts are used to analytically determine the impact of each design parameter such as switch resistance, flying capacitance, switching frequency, and parasitic resistance. A three-stage 2:1 SC converter supplying three different loads is considered as a case study to verify the proposed modeling technique.
Water Sorption and Glass Transition of Pig Gastric Mucin Studied by QCM-D

Field: Chemistry (Physical Sciences)

Hydration of films of pig gastric mucin was studied using a quartz crystal microbalance with dissipation monitoring (QCM-D) equipped with a humidity module. As a prerequisite, the water adsorption isotherm of a clean silica surface was determined. Atomic force microscopy was used to characterize the changes occurring on the silica surface after repeated sorption/desorption and cleaning cycles. The water sorption isotherms of several hundreds of nanometers thick mucin films were obtained in QCM-D experiments using analysis of overtone behavior. The results show that the sorption isotherms are not dependent on the film thicknesses and are in good agreement with sorption calorimetric data on mucin in the bulk phase. Moreover, hydration-induced changes of rheological properties of mucin films were investigated using a model-free approach. The ratio of G'/G″ was evaluated as a function of relative humidity. The transition from solidlike behavior to liquidlike behavior was observed in the same humidity range as in sorption calorimetric experiments. Thus, ability of QCM-D to monitor glass transition in biopolymers was demonstrated.
Isolation of 4-nerolidylcatechol from leaves of Piper peltatum L., and evaluation of larvicidal activity in mosquito vectors, with emphasis on Aedes aegypti (Diptera: Culicidae)

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Nascimento, Sara Raquel Lavareda, Pinto, Ana Cristina da Silva, Meireles, Sabrina da Fonseca, Silva, Junielson Soares da, Chaves, Francisco Celio Maia, Rafael, Míriam Silva (2024): Isolation of 4-nerolidylcatechol from leaves of Piper peltatum L., and evaluation of larvicidal activity in mosquito vectors, with emphasis on Aedes aegypti (Diptera: Culicidae). Revista Brasileira de Entomologia (e20230074) 68 (2): 1-8, DOI: 10.1590/1806-9665-RBENT-2023-0074, URL: http://dx.doi.org/10.1590/1806-9665-rbent-2023-0074
Spicule Form in Leucosolenia complicata

Field: Agricultural and Biological Sciences (Life Sciences)

ABSTRACT The tri- and quadriradiates of Leucosolenia complicata are described in four aspects: surface view, transverse view, side view, and planar view. The spicule form and size vary with the distance from the oscular edge in all four cases. In planar view (when the eye is directed along the optic axis) the spicule rays usually appear straight and thus exhibit a tendency to grow in planes which intersect in a line having the direction of the optic axis. The angle between the oscular ray planes (the planar angle) is always greater than 120° and the spicules hence belong to the ‘secondary sagittal’ class of von Ebner. The planar angle is not closely correlated with the optic angle and varies from about 160° at the oscular edge to about 140° at the base of the tube. This variation precludes the possibility that the angle is simply controlled by the crystallizing properties of calcite. The curvature of the choanoderm is a factor controlling spicule form because the formative calcoblasts move in contact with this layer when secreting their respective rays. Reasons are given for returning!,, coriacea (Montagu) to a separate genus, Clathrina.
Isolation and genetic characterisation of a metapneumovirus isolated from pederiatric patients in Singapore.

Field: Medicine (Health Sciences)

Human metapneumovirus (HMPV) is a newly identified member of the Family, Paramyxoviridae. The rirus was first discovered in year 2001 in hospotalised children in the Netherlands, and was found to cause mild respiratory infections in adults. However, evidence suggests that it can increase the severty of other respiratory viruses during co-infections. The proposed project will provide the first study to isolate and characterise HWPV from Singapre paediatric patients.
Ruta graveolens Protects Against Isoniazid/Rifampicin-Induced Nephrotoxicity through Modulation of Oxidative Stress and Inflammation

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background and Aim: Drug-induced nephrotoxicity is a renal dyfunction that arises as a result of exposure to nephrotoxic drugs.Anti-tuberculosis therapy can cause nephrotoxicity and permanent kidney damage.The current study was designed to evaluate the possible protective effects of Ruta graveolens L. leaves extract against isoniazid/rifampicin-induced nephrotoxicity in rats. Methods:The experimental rats received isoniazid and rifampicin at dose level of 50 mg/kg, and 50 or 100 mg/kg/day Ruta graveolens leaves extract orally for 45 days.Results: Isoniazid/rifampicin administration induced kidney injury evidenced by the histopathological alterations as well as significant (P<0.001)increase in serum creatinine, urea and uric acid.Isoniazid/rifampicin-intoxicated rats exhibited a significant increase in serum tumor necrosis factor alpha (P<0.001), and renal lipid peroxidation (P<0.01) and nitric oxide (P<0.001)levels.On the other hand, reduced glutathione level, and activity of superoxide dismutase and glutathione peroxidase were markedly (P<0.001) declined in kidney of isoniazid/rifampicin-induced rats.Concomitant supplementation with either 50 or 100 mg/kg dose of Ruta graveolens leaves extract prevented the isoniazid/rifampicin-induced biochemical and histopathological alterations. Conclusion:The present investigation confers new information on the protective mechanism of Ruta graveolens leaves extract on anti-tuberculosis therapy-induced nephrotoxicity.Ruta graveolens protects against isoniazid/rifampicin-induced renal injury through attenuation of inflammation and oxidative stress, and potentiation of the antioxidant defense system.
Corn stover harvest reduces soil CO2 fluxes but increases overall C losses

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Harvesting corn ( Zea mays L.) stover for use as bioenergy feedstock may provide short‐term economic benefits and perhaps improve grain yield in continuous corn systems, but excessive stover removal may lead to long‐term depletion of soil C stocks. To better quantify the impacts of stover harvest on the soil C balance, we investigated CO 2 fluxes under three harvest treatments (none, moderate, and high) in three continuous corn systems: (a) no tillage and no biochar applications, (b) chisel plowing with biochar amendments, and (c) chisel plowing without biochar amendments were quantified. We sampled static chambers 14, 13, and 15 times in 2010, 2011, and 2012, respectively, and the measurements were used to calibrate the Agricultural Production Systems sIMulator model. Although CO 2 ‐C emissions did not differ among the three systems, both moderate (approximately 30%) and high (approximately 60%) stover removal rates reduced simulated CO 2 ‐C emissions by nearly 10% and more than 22%, respectively. Despite these reductions in CO 2 flux, the sum of CO 2 ‐C and stover C exceeded CO 2 ‐C losses in those plots without stover removal. This finding suggested soil C depletion was occurring for the soil and crop management practices used, even though depletion was not evident after 3 years. Application of biochar increased soil C levels, suggesting it may be able to offset some C losses. We conclude that for sustainable, highly productive agroecosystems that include stover harvest, all agronomic practices must be optimized to minimize C losses and maintain soil quality.
Machine Vision Using Image Gradients for Spray-Deposit Analysis: Software Development

Field: Computer Science (Physical Sciences)

Software was developed to automatically analyze images of spray deposits on planar surfaces. Spot boundaries, which are extracted using image gradients rather than gray-level thresholds, are used to calculate spot and drop size distributions, spot counts, and coverage. The software was tested with spots ranging in size from 100 to 1600 mm generated on kromekote paper. Effects of spot contrast, orientation of oblong spots, camera aperture setting, and magnification on spot count and measured size were evaluated. Counting and sizing errors of 1 to 2% are possible with appropriate magnification and contrast.
Green Generation: Inisiasi Gen Z dalam Membangun Revolusi Green Economy bidang Pangan

Field: Social Sciences (Social Sciences)

The global food crisis, climate change, and environmental degradation present real challenges that require innovation and the transformation of the food system toward a Green Economy. Generation Z, characterized as digital natives who are highly adaptive to technology and deeply concerned about environmental issues, has the potential to become a Green Generation leading the green economic revolution in the food sector. This study aims to examine Gen Z’s initiatives in building a Green Economy in the food sector, analyze the strategies implemented, and identify supporting and inhibiting factors. A descriptive qualitative approach was applied through literature review, policy analysis, and case studies on young farmer programs and sustainable food innovations. The findings reveal that Gen Z contributes to the development of precision agriculture, organic farming, and diversification of environmentally friendly food products based on local wisdom. These initiatives strengthen national food security, create green business opportunities, and establish a sustainable food ecosystem. In conclusion, Gen Z’s active role in the food sector is the key to accelerating the Green Economy revolution, with success highly dependent on policy support, technical assistance, and cross-sector partnerships.
Neritius kebreabstretchi Jago 1994

Field: Agricultural and Biological Sciences (Life Sciences)

Neritius kebreabstretchi Jago, 1994 http://lsid.speciesfile.org/urn:lsid: Orthoptera.speciesfile.org:TaxonName:47744 Material examined. ETHIOPIA: Oromia, Bale, Gaysay grasslands, Bale Mountains N.P., 9.XII.2015, B. Massa (2Ƌ, 2♀, 6 nymphs) (BMPC). Distribution. Endemic to the Bale Mountains, N.P. region. Remarks. The specimens were collected near the type locality. In December 2015 nymphs were quite common in and around bushes at the Gaysay grasslands. Jago (1994) collected both adults and nymphs in October, and possibly the phenology of this small Neritius covers much of the autumn-winter season.
Multiplicity of kappa opioid receptor binding in the rat cardiac sarcolemma.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

In order to determine the opioid receptor binding in the rat cardiac sarcolemma, direct and displacement binding assays of tritiated bremazocine, a nonselective opioid, agonist and U69593, a specific kappa-receptor agonist, were performed in a sarcolemmal membrane preparation. Saturation studies revealed that there were substantial binding sites for both radioligands. The [3H]bremazocine had a binding capacity of 100 fmol/mg protein with a Kd of 3.4 nM while the binding of [3H]U69593 showed a Kd of 7.4 nM and a Bmax of 139 fmol/mg protein. Displacement binding assay showed that [D-Ala2, MePhe4, Gly-(ol)5]enkephalin (DAGO), a specific mu-agonist, exhibited no inhibitory effect on the binding of either [3H]bremazocine or [3H]U69593. [D-Ala2,D-Leu5]enkephalin (DADLE), a specific delta-agonist, had no inhibition on the binding of [3H]U69593, but displaced the binding of [3H]bremazocine at higher concentrations (10(-5)-10(-6)M). U50488, a specific kappa-agonist, completed with the binding of [3H]U69593 23 times more potently than with the binding of [3H]bremazocine. A residual binding sites of [3H]bremazocine was found with a Kd of 6.4 nM and a Bmax of 76 fmol/mg protein under conditions in which mu, delta and kappa 1 opioid bindings were suppressed by DAGO and DADLE at 200 nM and U50488 at 1 microM. DADLE at 5 microM, a concentration known to block kappa 2 binding sites, abolished the residual U50488-insensitive specific binding of [3H]bremazocine. Met5-Enkephalin-Arg6-Phe7, a specific kappa 2 ligand, displaced the binding of [3H]bremazocine much more readily than the binding of [3H]U69593. The present study provided evidence for the presence of two kappa-receptor subtypes in the cardiac sarcolemma: one U50488-sensitive and DADLE-insensitive, and the other U50488-insensitive and DADLE-sensitive. These two kappa-receptor binding subtypes may correspond to kappa 1 and kappa 2 receptor subtypes. Computer assisted non-linear regression analysis in the competition experiments of U50488 with [3H]U69593 afforded a best fit of the inhibition curves for two displacing components of kappa 1 binding sites: one with high affinity and low Bmax, another with low affinity and high Bmax.
Additional file 15 of Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, human papillomavirus (HPV) status, and sensitivity to tyrosine kinase inhibitors

Field: Medicine (Health Sciences)

Additional file 15: Fig. S13. This figure illustrates correlation and association of FGF14 DNA methylation with mRNA expression, HPV status, copy number variation, and sensitivity to the FGFR-targeted TKIs PD 173074 and AZD4547. Exemplarily, results of ten selected CpG sites within FGF14 are illustrated.