jimnoneill/paper-to-field-training huggingface dataset:
IL-17A induced hematopoietic reprogramming produces both PMN and MDSC at the post-acute stage of inflammation.

Field: Immunology and Microbiology (Life Sciences)

Abstract Our previous study suggests that polymorphonuclear leukocyte (PMN) response is enhanced at the post-acute stage of murine colitis due to changes in bone marrow (BM) myelopoiesis. Herein, we report that hematopoietic reprogramming during the post-acute phase of inflammation produces myeloid derived suppressor cells (MDSC) that co-infiltrate the intestine with PMN. Employing Percoll density gradients, we analyzed dynamic changes to the myeloid compartment by separating BM leukocytes from DSS colitis-to-recovery mice into four density-increasing bands with myeloid leukocytes enriched in bands III (50–60%) and IV (60–70%). Band III was comprised of monocytes and low-density granulocytes; both confirmed to be M-MDSCs and G-MDSCs, respectively, by displaying potent inhibition of T-cell proliferation. Despite significant decreases in the PMN population, presumably caused by mobilization into inflamed tissues, MDSC numbers significantly increase beginning at the post-acute stage of colitis. Furthermore, MDSC numbers do not return to baseline until late in the recovery stage. The expanded G-MDSCs also showed increased CXCR2 expression, which guides egress out of BM, and produced ROS upon PMA activation. Adoptive transfer assays demonstrated that functionally enhanced PMN infiltrated the intestine at the post-acute stage to clear the existing inflammatory reaction, while MDSC accumulated in the intestine during recovery suggesting a role in tissue repair. IL-17A signaling at the post-acute stage of inflammation likely induced hematopoietic reprogramming of the myeloid compartment, as its neutralization blocked expansion and infiltration of both PMN and MDSC.
Magnetic Properties of Monodispersed Ni/NiO Core−Shell Nanoparticles

Field: Materials Science (Physical Sciences)

We have recently developed a method to fabricate monodispersed Ni/NiO core-shell nanoparticles by pulsed laser ablation. In this report, the size-dependent magnetic properties of monodispersed Ni/NiO core-shell nanoparticles were investigated. These nanoparticles were formed in two steps. The first was to fabricate a series of monodispersed Ni nanoparticles of 5 to 20 nm in diameter using a combination of laser ablation and size classification by a low-pressure differential mobility analyzer (DMA). The second step was to oxidize the surfaces of the Ni particles in situ to form core-shell structures. A superconducting quantum interference device (SQUID) magnetometer was used to measure the magnetic properties of nanostructured films prepared by depositing the nanoparticles at room temperature. Ferromagnetism was observed in the magnetic hysteresis loop of the nanostructured films composed of core-shell nanoparticles with core diameters smaller than the superparamagnetic limit, which suggests the spin of Ni core was weakly exchange coupled with antiferromagnetic NiO shell. In contrast, smaller nanoparticles with core diameters of 3.0 nm exhibited superparamagnetism. The drastic change in the hysteresis loops between field-deposited and zero-field-deposited samples was attributable to the strong anisotropy that developed during the magnetic-field-assisted nanostructuring process.
[Cases of cavernous hemangioma discovered in patients with post traumatic intracerebral hematoma].

Field: Medicine (Health Sciences)

Cavernous haemangioma has various forms. The cases with spontaneous intracerebral haemorrhage are most common, but post-traumatic intracerebral haematoma was not reported. The aim of this report is to present cases of cavernous haemangioma with unusual clinical course. In seven patients with post-traumatic intracerebral haematoma, fragments of histologically confirmed cavernous haemangioma tissue situated in the place of haematoma were found. In one case, delayed intracerebral haematoma twenty four hours after trauma and initial CT-scan was observed. On the initial CT-scan in this patient only traumatic changes in the brain without haematoma or tumour were present. In our cases, cavernous haemangioma was situated most frequently in frontal and temporal region, shown as haematoma usually 24 hours after trauma, mainly in men in age range 30-44 years with disorders of consciousness (GCS 11). As the result of operation, the majority of patients (6 out of 7) were discharged as self-independent. The authors reviewed the literature for cavernous haemangioma. The tumour may be present in any region of the brain including infratentorial region. The lesion is disclosed most frequently in children as spontaneous brain haemorrhage and rarely as seizures or intracranial hypertension. Final diagnosis is based on cerebral angiography or MRI. CT-scans are not typical and before the appearance of haematoma do not suggest the presence of tumour. Surgical removal of haematoma with tumour fragments is the main method of therapy, but radiation is possible in order to diminish the mass. The authors conclude that in each patient with post-traumatic intracerebral haematoma, the presence of cavernous haemangioma is possible.
Reproductive success of Baker’s Globe Mallow and its association with a native specialist bee

Field: Agricultural and Biological Sciences (Life Sciences)

Baker's globe mallow, a fire-following mallow endemic to the Modoc Plateau of northeast California and southern Oregon, has recently been designated a sensitive species. Management conservation decisions for such rare species are strengthened by information on natural history, but little is known about this plant. Our objectives are to describe aspects of its reproductive success in several occurrences of different burn age and size, to determine its need for pollinators in sexual reproduction, and to identify important flower-visitors. Reproductive success (fruits/flower, seeds/fruit) for Baker's globe mallow varied significantly across occurrences, and was not associated with age or size of burn. There were significant positive correlations between fruits/flower and site elevation, and with distance to nearest burn. There was no phenological pattern to fruit or seed production, nor were clumped plants more likely to produce fruits or seeds than isolated plants. Flowers did not set fruit or produce seeds without pollinator visitation. The most abundant flower-visitor in most occurrences was Diadasia nitidifrons, a native solitary bee that visits only flowers of plants in the mallow family. Diadasia nitidifrons was present in all Baker's globe mallow occurrences monitored, including those most isolated. The plant's need for pollinators, and the tendency for plants in occurrences with the highest visitation to set the highest proportion of fruits per flower, suggests that Diadasia nitidifrons is vital to the reproductive success of Baker's globe mallow if it proves to be superior to generalist bees at pollen deposition. Pollinator effectiveness comparisons for abundant visitors are needed.
Effects of ginger (Zingiber officinale) on the growth performance, digestive enzyme activity, antioxidative response, and antibacterial capacity of striped catfish (Pangasianodon hypophthalmus) reared in outdoor conditions

Field: Agricultural and Biological Sciences (Life Sciences)

Unstable outdoor farming conditions weaken fish's health status and immunity, leading to high susceptibility to infectious diseases and low productivity. Feed additives have been applied recently to enhance the growth performance and well-being of striped catfish. This study evaluated the effects of ginger (Zingiber officinale) on the growth performance, digestive enzyme activity, antioxidative response, and antibacterial capacity of striped catfish. Control and three test diets were supplemented with ginger rhizomes powder at 0.5 %, 1 %, and 1.5 %. After 90 days, the growth performance of striped catfish fed dietary ginger was marginally increased, with the highest being in the group receiving 1 % (p < 0.05). However, the feed conversion ratio was reduced following the same trend, with the lowest being in fish fed at 1 %. Fish fed 1 % ginger had the highest growth hormone level than the remaining groups (p < 0.05). The carcass composition, including total protein and lipids, was meaningfully affected by dietary ginger, while ash and fibers were unaffected. Amylase, protease, and lipase activities were significantly higher in striped catfish fed dietary ginger than in the control. The total protein, albumin, and globulin were significantly higher in striped catfish fed 1 % and 1.5 % ginger than 0 % and 0.5 % (p < 0.05). Superoxide dismutase, catalase, and glutathione peroxidase were significantly higher in striped catfish fed ginger regardless of the dose. On the other hand, the malondialdehyde (MDA) level was markedly reduced by dietary ginger in striped catfish, and those who received 1.5 % had the lowest MDA level. The Vibrio spp. and fecal coliform were markedly reduced by dietary ginger in striped catfish intestines. Interestingly fish fed 1.5 % had the lowest count for Vibrio spp. and fecal coliform. Overall, based on the regression analysis results, dietary ginger should be added at 1.02–1.58 % in the diets of striped catfish to show the best performance and well-being.
Clinical and experimental evaluation of ureteric dilatation.

Field: Medicine (Health Sciences)

The present study was designed to evaluate the effect of ureteric dilatation (performed as a prelude to rigid ureteroscopy) on the vesicoureteric mechanism in experimental animals and man. Through a vesicotomy the left ureteric orifices of 10 anaesthetised male New Zealand White rabbits were dilated approximately 3-fold (to 4-5F) using Seldinger wires and gradated cannulae. Serial intravenous urograms and histological examination of the excised vesicoureteric junctions were performed at intervals of 2 weeks. Histologically, acute inflammatory changes were noted at 24 h, but at 2 to 8 weeks the histological appearances were normal. Radiologically, transient upper tract dilatation was noted in three animals. In 10 patients, intravenous urograms and micturating cystograms were performed 3 months after ureteric dilatation to 14F (prior to ureteroscopy). One asymptomatic patient had grade 1 vesicoureteric reflux but no other radiological abnormalities were found. It is concluded that ureteric dilatation is a safe procedure which merits reassessment as a urological technique.
Beyond Debate: Gender in Play in Old French Courtly Fiction

Field: Arts and Humanities (Social Sciences)

Many courtly fictions, thought of as a site for articulating and promulgating normative gender roles, also debated, and sometimes (temporarily) destabilized, gender identities. Just at a time when formal debates about women circulated in Latin and Old French, a number of courtly texts questioned the nexus of gender, language, and power. Marie de France's Guigemar, the chantefable Aucassin et Nicolette, and Heldris de Cornualle's Roman de Silence serve as illustration.
Identification and Investigation of Phenotypic and Genotypic Characteristics of FlavobacterÄÂ±um PsychrophÄÂ±lum ÄÂ±n Fry RaÄÂ±nbow Trouts (Oncorhynchus MykÄÂ±ss) in Some Trout

Field: Veterinary (Health Sciences)

In this study, it was aimed to identify and investigate phenotypic and genotypic charecteristics of Flavobacterium psychrophilum in four rainbow trout farms in Keban district of ElazÄÂ±ÄÅ¸ province. Two different primers were used to confirm 160 Flavobacterium psychrophilum with PCR after determined according to the phenotype and genotype characteristics. Subsequently, these strains were confirmed as Flavobacterium psychrophilum with DNA. Gene typing was performed with PFGE technique on strains confirmed with PCR. As a result of this, it was decided that strains obtained from four different fish farms wasclose relative with reference Flavobacterium psychrophilum NCIMB 1947T.
The Effect of Calcineurin Inhibition on the Expression and Activation of Renal Electrolyte Transporters

Field: Medicine (Health Sciences)

Tacrolimus (FK506) is a calcineurin inhibitor (CNI), and the main immunosuppressant used in organ transplantation. It causes complications such as hypertension, hyperkalaemia, hypercalciuria and acidosis. Together with insulin resistance, dyslipidaemia and obesity, they comprise the metabolic syndrome. CNIs induce hypertension through the activation of the WNK-NCC cascade, causing an increase in sodium chloride reabsorption, and phosphorylation is an important post-translational modification that alters the activity of the members in the WNK-NCC cascade. Using quantitative phosphoproteomics and several bioinformatic techniques, a phosphoproteome profile of the renal cortices from FK506-treated mice was generated and phosphoproteins involved in renal tubular transport were identified. In this data, AKT was phosphorylated by FK506 and was suggested to act as the intermediary protein in the calcineurin-WNK cascade. In addition, ERK1/2 was also dysregulated by FK506 and was suggested to regulate NCC through the WNK4-ERK1/2 pathway. The phosphoproteome profile also revealed several FK506-dysregulated phosphoproteins that are involved in sodium, acid-base, glucose and potassium handling. CNIs have been suggested to cause hypercalciuria through a decrease in TRPV5 and calbindin-D28K expression, however, the effect of FK506 on other regulatory and transport proteins involved in calcium handling is unclear. In contrast to previous studies, FK506 did not dysregulate TRPV5 expression, but instead increased the expression of the basolateral calcium transporters, NCX1 and PMCA. Based on these findings, a novel mechanism explaining CNI-induced hypercalciuria, driven by the activation of NCC, is proposed and the relationship between sodium and calcium handling in the DCT is discussed. The effects of calcineurin inhibition on renal electrolyte transporters and their potential regulators induce salt-sensitive hypertension and hypercalciuria. The findings presented in this thesis contribute to the understanding of the underlying mechanism that governs sodium and calcium handling in the DCT and full elucidation of this molecular machinery is of interest and clinical importance.
[Adjuvant therapy of colon cancer stage C MAC. Adverse effects and efficacy in the Department of Oncology, Soroka Medical Center in the years 1991-1994].

Field: Medicine (Health Sciences)

The National Institutes of Health (NIH) held a consensus conference which recommended 5-FU and levamisole as adjuvant chemotherapy for colon cancer MAC (Modified Astler Coller) stage C. From 1991-1994, 37 such patients diagnosed here were treated with 5-FU (intravenous dose of 450/mg/m2/d for 5 days and from day 29, once a week for 48 weeks) and oral levamisole (50 mg 3 times/d. for 3 days, every 2 weeks for a year), as suggested by NIH guidelines. 16 patients were males and 21 were females, mean age was 62 years and median 64. Cancer locations were: right colon (in 16, 43%), left colon (19, 51%), multiple colon primaries (2, 1%). 25 (68%) had 1-3 positive lymph nodes and 12 (32%) had 4 or more positive lymph nodes. Only 20 (54%) finished treatment as prescribed. In the others, 1 or both drugs caused side-effects for which the drugs had to be stopped. 6 patients relapsed while on treatment. The most common side-effects were diarrhea, stomatitis and bone marrow suppression. 3 were hospitalized due to neutropenic fever. 5-year actuarial survival of all patients was 61%; 5-year relapse-free survival was 61%; 5-year relapse-free survival of right versus left colon was 41% and 82%, respectively (p < 0.01). There was no significant difference in 5-year survival of those with 1-3 positive lymph nodes as compared to those with 4 or more (62% and 56%, respectively). 5-year survival in those who finished or did not finish treatment (excluding those who stopped treatment because of progressive disease) was 83% and 70%, respectively (NS). The 5-year survival of our series was similar to that of patients treated similarly elsewhere. The 5-FU and levamisole treatment was not tolerated well by our study population. It has recently been replaced in our service by a 5-FU and leucovorin regimen given for 6 months.
ElectroVizQA: How well do Multi-modal LLMs perform in Electronics Visual Question Answering?

Field: Computer Science (Physical Sciences)

Multi-modal Large Language Models (MLLMs) are gaining significant attention for their ability to process multi-modal data, providing enhanced contextual understanding of complex problems. MLLMs have demonstrated exceptional capabilities in tasks such as Visual Question Answering (VQA); however, they often struggle with fundamental engineering problems, and there is a scarcity of specialized datasets for training on topics like digital electronics. To address this gap, we propose a benchmark dataset called ElectroVizQA specifically designed to evaluate MLLMs' performance on digital electronic circuit problems commonly found in undergraduate curricula. This dataset, the first of its kind tailored for the VQA task in digital electronics, comprises approximately 626 visual questions, offering a comprehensive overview of digital electronics topics. This paper rigorously assesses the extent to which MLLMs can understand and solve digital electronic circuit questions, providing insights into their capabilities and limitations within this specialized domain. By introducing this benchmark dataset, we aim to motivate further research and development in the application of MLLMs to engineering education, ultimately bridging the performance gap and enhancing the efficacy of these models in technical fields.
Recombining tree approximations for Game Options in Local Volatility models

Field: Mathematics (Physical Sciences)

In this paper we introduce a numerical method for optimal stopping in the framework of one dimensional diffusion. We use the Skorokhod embedding in order to construct recombining tree approximations for diffusions with general coefficients. This technique allows us to determine convergence rates and construct nearly optimal stopping times which are optimal at the same rate. Finally, we demonstrate the efficiency of our scheme with several examples of game options.
Spontaneous Supraceliac Isolated Abdominal Aortic Dissection Sparing Major Visceral and Renal Vessels and Presenting as Chronic Limb Ischemia

Field: Medicine (Health Sciences)

Aortic dissections that originate from isolated tears in the abdominal aorta are uncommon. Rarer still are cases of isolated abdominal aortic dissections arising in suprarenal locations, as most appear from infrarenal intimal defects. We present a quite unusual case of a spontaneous supraceliac isolated abdominal aortic dissection sparing the renal and mesenteric arteries and manifesting as chronic rather than acute limb ischemia. The atypical presentation of this case led to repeated misdiagnosis with consequent loss of part of the patient's limb. Better illustration of the natural history of this ill-defined pathology is needed to aid understanding and improve patient care.
University entrepreneurial support and green entrepreneurial behavior: a quantitative serial mediation

Field: Business, Management and Accounting (Social Sciences)

Abstract This study aims to delineate the influence of university support for entrepreneurship on fostering green entrepreneurial behaviours, specifically examining the roles of entrepreneurial self-efficacy and green entrepreneurial intention as sequential mediators in this relationship. Employing a quantitative methodology, data from 338 Thai entrepreneurs were collected through a structured survey using convenience sampling techniques. The analysis reveals that university support positively influences green entrepreneurial behaviors. Specifically, university support positively increases entrepreneurial self-efficacy, which, in turn, positively influences green entrepreneurial intentions. This sequential mediation demonstrates that the positive relationship between university support and green entrepreneurial behaviors is enhanced by the mediating roles of entrepreneurial self-efficacy and green entrepreneurial intentions. This underscores the critical role of universities in boosting self-efficacy among budding entrepreneurs and cultivating their green intentions, which are essential for sustainable entrepreneurial practices. This study is an exploratory step in understanding university support and green entrepreneurship dynamics. Future research could incorporate longitudinal data collection to establish causality more definitively and include industry-specific factors (e.g., regulatory frameworks, market demand for green products) and the economic climate (e.g., access to green financing, government incentives) to provide a more nuanced understanding of this relationship. Furthermore, future studies should employ probability sampling methods, such as stratified random sampling, to enhance the generalizability of the findings to a broader population of entrepreneurs. This research pioneers in illustrating the interconnected pathways through which university support can translate into green entrepreneurial actions. By integrating serial mediation analysis, this study offers new insights into the sequential impacts of university support on entrepreneurial self-efficacy and intention, highlighting their importance in fostering sustainable entrepreneurial outcomes.
Jasmonate Induced Inhibition of Colletotrichum lindemuthianum (Sacc. & Magnus) Briosi & Cavara in Lablab purpureus L. Sweet under in vitro Conditions

Field: Agricultural and Biological Sciences (Life Sciences)

The objective of this study was to evaluate the protective role of Jasmonic acid in Lablab purpureus L. Sweet against Anthracnose disease.Colletotrichum lindemuthianum was cultured in PDA medium supplemented with 0.5µM, 1µM, 2µM and 5µM concentrations of Jasmonate.Supplementation of JA was found to inhibit radial growth of C. lindemuthianum after 7 days incubation.The effective concentration of JA was 1µM with 50% of inhibition of radial growth.When fresh pods of Lablab purpureus were punctured to a 0.5cm of diameter using a sterile cork borer and replaced with Colletotrichum lindemuthianum culture discs with or without JA solution the lesions began to appear after 7days at 24 °C incubation.JA at 2µM concentration significantly reduced the lesion to 0.7cm.Thus, the in vitro study helps to confirm the protective role of JA.