jimnoneill/paper-to-field-training huggingface dataset:
Autologous fibroblast implantation. Feasibility and potential problems in gene replacement therapy.

Field: Medicine (Health Sciences)

Autologous implants of genetically modified fibroblasts may be an ideal approach to gene replacement therapy. However, primary fibroblasts have limited life span and their use for gene therapy is questionable. We have developed a rat model to evaluate the feasibility of this approach. Primary fibroblasts initiated from rat skin biopsies were transfected with plasmid DNA. The transkaryotic fibroblasts were implanted into the original rat donors. A plasmid-encoded gene product, human growth hormone, was detected in the donor rats' circulation but less than 1% of the expected amount was recovered. Implantation at intraperitoneal, intramuscular or subcutaneous sites were effective in delivering the novel gene product. Fluctuating levels of human growth hormone were detected for over 6 months but their determination was rendered unreliable due to interference by extremely high titers of antibodies developed against the human growth hormone. In some cases, the antibody titer continued rising for more than 6 months, indicative of the continued presence of the antigen. One of the recipients developed two intra-abdominal fibrosarcomas that were shown to be derived from the implanted cells. In conclusion, this model demonstrates that autologous fibroblast implantation is a feasible approach to delivering novel gene products lasting for several months. Strong and prolonged immuno-reaction against the gene product will occur if the recipient's immune system is naive to the replacement product, as would occur in patients with CRM- mutations. The potential for neoplastic development from the implanted fibroblasts should prompt further evaluation of the long-term safety in gene replacement therapy.
Review Article The Thromboembolic Risk in Giant Cell Arteritis: A Critical Review of the Literature

Field: Medicine (Health Sciences)

Copyright © 2014 A. Guida et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Giant cell arteritis is a systemic vasculitis characterized by granulomatous inflammation of the aorta and its main vessels. Cardio-vascular risk, both for arterial and venous thromboembolism, is increased in these patients, but the role of thromboprophylaxis is still debated. It should be suspected in elderly patients suffering from sudden onset severe headaches, jaw claudication, and visual disease. Early diagnosis is necessary because prognosis depends on the timeliness of treatment: this kind of arteritis can be complicated by vision loss and cerebrovascular strokes. Corticosteroids remain the cornerstone of the pharmacological treatment of GCA. Aspirin seems to be effective in cardiovascular prevention, while the use of anticoagulant therapy is controversial. Association with other rheumatological disease, particularly with polymyalgia rheumatica is well known, while possible association with antiphospholipid syndrome is not established. Large future trials may provide information about the optimal therapy. Other approaches with new drugs, such as TNF-alpha blockades, Il-6 and IL-1 blockade agents, need to be tested in larger trials. 1.
Contrast-enhanced ultrasonic evaluation of characteristics of renal VX2 tumor in rabbit models

Field: Medicine (Health Sciences)

Objective To investigate the value of contrast-enhanced ultrasound(CEUS) in monitoring and evaluating the growth characteristics of VX2 renal tumor in rabbit models.Methods Twenty rabbits were operated and VX2 carcinoma was transplanted into the kidney using tumor tissue embedding method.Then rabbits were divided into 4 groups randomly,and CEUS examimation were made 1,2,3 and 4 weeks after the transplantation,respectively.The rabbits were killed immediately after CEUS,and the kidney tumors were resected for pathological examination.Results All the models were established successfully.There was no statistical difference between the volume of VX2 tumors measured with CEUS and pathology(all P0.05).There was consistency between the two methods.All VX2 tumors showed hypoechoic enhancement in CEUS,and the enhancement was lower than renal parenchyma.In arterial phase VX2 tumors showed different enhancement patterns,tumors post-transplanted 1—2 weeks were mainly homogeneous enhancement(7/10),tumors post-transplanted 3—4 weeks were mainly peripheral enhancement(8/10).Conclusion CEUS can accurately measure the diameter of the VX2 renal tumor and display the intratumoral vascularity in rabbit models.CEUS has important value in monitoring the growth and evaluation the characteristics on renal VX2 tumor in rabbits.
Case Studies for Improving FMS Scheduling by Lot Streaming in Flow-Shop Systems

Field: Decision Sciences (Social Sciences)

Abstract: This paper deals with scheduling problems of the Flexible manufacturing systems (FMS). The objective is to improve the utilization of FMS. Lot Streaming (LS) is used to meet this objective. In this paper a comparative study is performed between the applications of new methods: Brute Force method (BFM) and Joinable Schedule Approach (JSA). Case studies for Flow Shop Systems (FSS) are performed. Attached independent sequence setup times are considered. It is concluded that these methods can be used effectively to solve LS problems. In the paper a general optimization mathematical model of LS for FMS scheduling problems of FSS is developed and presented.
Dampak Pastoral Konseling Dengan Menggunakan Intervensi Psychodelsi terhadap Penurunan Kemarahan dan Peningkatan Pengampunan Kepada Mahasiswa STT Anugerah Misi Nias Barat

Field: Psychology (Social Sciences)

Abstract: This article is a research conducted on students at the Anugerah Misi College of Theology (STT) West Nias specifically who took the Pastoral Counseling II class. In this process, students are guided by the theory popularized by Rev. Jaharianson Saragih in his book Psychodelsi (Psycho, Deliverance, Spiritual) carries out direct practice as a counselor for others and also as a counselee or client. By using qualitative research through library research and field research through direct practice, researchers studied and found that many students studying theology still had bitter roots, namely anger towards their parents, specifically towards their father. Through direct practice using the life story method and typology or personality as well as tracing the family tree (genogram), clients discover the roots of the bitterness they experience stems from anger that has been stored for years. After this process, the client is guided to forgive the people who have hurt him. After going through a pastoral counseling process using psychological, deliverance and spiritual approaches, the client is finally free from anger and makes the decision to forgive and get relief. Keywords: Counseling Pastoral, Psichodelsy, anger, forgiveness. Abstrak: Artikel ini merupakan sebuah penelitian yang dilakukan terhadap mahasiswa-mahasiswi di Sekolah Tinggi Teologi (STT) Anugerah Misi Nias Barat secara khusus yang mengikuti kelas Konseling Pastoral II. Pada proses ini mahasiswa dengan mempedomani teori yang dipopulerkan oleh Jaharianson Saragih dalam bukunya Psychodelsi (Psycho, Deliverance, Spiritual) melakukan praktik langsung menjadi konselor bagi sesamanya dan juga sekaligus menjadi konseli atau klien. Dengan menggunakan penelitian kualitatif melalui penelitian kepustakaan (library research) dan penelitian lapangan (field research)melalui praktek secara langsung, peneliti mengkaji dan menemukan bahwa banyak mahasiwa yang belajar teologi masih menyimpan akar pahit yaitu berupa kemarahan terhadap orang tua secara khusus terhadap ayahnya. Melalui praktek langsung dengan menggunakan metode life story dan tipologi atau kepridian serta penelusuran pohon keluarga (genogram), klien menemukan akar pahit yang dialami bersumber dari kemarahan yang tersimpan selama bertahun-tahun. Setelah proses itu, klien dituntun untuk mengampuni orang-orang yang telah menyakiti hatinya. Setelah melalui proses konseling pastoral dengan pendekatan psychologi, deliverance dan spiritual akhirnya klien terbebas dari kemarahan dan mengambil keputusan untuk mengampuni dan mendapatkan kelegaan.
Gender and Educational Leadership

Field: Social Sciences (Social Sciences)

It is imperative to achieve gender equality in educational institutions. Gender equality focuses on initiatives aimed at achieving parity between the two genders, ensuring that both can enjoy equal advantages in all aspects of life. One possible measure is to introduce education management practices in educational institutions. The objective of this study is to investigate possible gender differences in education leadership. In order to do so 22 female education professional aged between 30 to 60 years old (47±8,3) with 18 (±7,3) years of experience took part in the study. The results revealed gender inequalities in favor of men. Still, the views of the respondents were affected by their demographics, age, experience, educational level and family status.
Light response of cut-flower Chrysanthemum cultivars

Field: Agricultural and Biological Sciences (Life Sciences)

Plant physiological activities can be analyzed from the photosynthetic light response curve. In the present study, light response curves in 25 cut-flower chrysanthemum cultivars in southern China were examined. The results indicated that important photosynthetic parameters such as photosynthetic capacity, average or maximum net photosynthetic rate (P N), light compensation point (LCP), and light saturation point (LSP) were different among cultivars. The summer blooming chrysanthemum had significantly higher maximum P N and LSP than the fall blooming chrysanthemum. There were insignificant differences in LCP and quantum yield (Y Q) between the fall and summer blooming chrysanthemum. According to the LCP and LSP, the cultivars tested can be classified into four groups, shade endurance group, heliophile group, widely adaptable group and narrow light group. Key words: Light response, summer blooming chrysanthemum, fall blooming chrysanthemum.
THE ALIENATION OF LOCAL COMMUNITIES IN TOURISM VILLAGES: A STUDY ON THE OSING COMMUNITY TOURISM VILLAGE IN BANYUWANGI REGENCY

Field: Social Sciences (Social Sciences)

Tourism is one of the key sectors in the local economy, especially in areas rich in culture and local wisdom like Banyuwangi Regency. Kemiren Village, inhabited by the Osing indigenous community, has been designated as a tourist village. However, the development of this tourist village often alienates the local community from the decision-making process, reducing their role and the benefits they should receive. This study aims to examine the involvement of the Osing community in the development of Kemiren Tourism Village and the impact of alienation on their economic, social, and cultural well-being. Based on Karl Marx’s theory of alienation, this study uses five indicators of alienation: powerlessness, meaninglessness, social isolation, normlessness, and self-estrangement. This theory helps to understand how communities feel disconnected from the processes and outcomes they should be involved in and benefit from. This research employs a qualitative approach with a case study method. Data collection was conducted through semi-structured interviews, observation, and document analysis. The informants include the village head, traditional leaders, and community members directly involved in the development of Kemiren Tourism Village. The findings show that the Osing community in Kemiren Village experiences alienation during the development of the tourist village. Although their involvement was minimal in the planning stage, positive adaptation was observed in the implementation phase, particularly in preserving local culture and boosting the economy through tourism activities. Active participation in the implementation stage reduces the sense of alienation, but more inclusive involvement is necessary to ensure a fairer distribution of benefits. More inclusive involvement and empowerment strategies focused on the local community are essential to reduce alienation and improve the economic, social, and cultural well-being of the Osing community in Kemiren Tourism Village. These findings provide a foundation for designing more sustainable and equitable tourism village development policies.
Performance Analysis of Stock Price Prediction Model using LSTM and BiLSTM

Field: Computer Science (Physical Sciences)

Abstract: In the world of market price prediction, price prediction plays an important role in terms of providing investors with an opportunity to reduce risk while making a profit. A successful prediction model has the potential to have a significant impact on industry. For prediction, researchers use a variety of methods. We used two recurrent neural network models in our research: long short term memory and bidirectional long short term memory network model. This model can assist in determining the first accurate stock price with high accuracy. Keywords: LSTM, Bi-LSTM, RNN, Deep learning, Stock price prediction
[How I treat...The choice between a sulphonylulrea and a gliptin to manage hyperglycaemia in type 2 diabetes].

Field: Medicine (Health Sciences)

The pharmacological therapy of hyperglycaemia in type 2 diabetes becomes increasingly complex. After failure of metformin monotherapy, several choices are possible. In clinical practice, the most common dilemma is to choose between adding a sulphonylurea or adding a dipeptidyl peptidase-4 inhibitor (gliptin). This review analyses the arguments in favour of one or the other pharmacological option, based upon criteria of efficacy, tolerance, safety, easiness of use, use in at risk populations and, last but not least, cost of therapy. In general, a patient-centered approach is recommended with an individualization of the therapy in function of the characteristics of each patient with the aim to obtain the best benefits/ risks ratio, at an affordable cost.
Robust Multi-agent Mission Operations Management For Heterogeneous Aerial And Space-based Robotics

Field: Computer Science (Physical Sciences)

Unmanned Aerial Vehicles (UAVs) have become cheaper and more technologically advanced over the past five years, with uses in academia, industry, and government projects. A promising application of UAV technology is multi-agent swarms: using multiple drones to accomplish a group of tasks cooperatively. Currently, drone swarms have been used to aid search and rescue efforts, increase security systems, and produce awe-inspiring art installations. They are even used by groups like NASA to simulate advanced distributed systems, such as satellite constellations. However, as the hardware and sensing capabilities of UAVs increases, so too does the complexity of managing these swarms. Most swarm deployment systems are homogeneous: platforms are identical and assigned one overarching task. There is no allowance for specializations in platform capabilities. This undercuts the benefits of distributed computing: it is operationally restrictive to use custom, specialized UAVs in a large swarm, as the platform management is problematic and impractical. This leads to heavy implementation restrictions for novel sensors in swarms, due to high costs of integration and deployment. The research of this dissertation creates a fleet mission management system that allows for multiple UAVs to cooperate and accomplish a multitude of mission types. The system employs new control law methods and flight software standards to coordinate the autonomous flight of drones in restrictive environments, while also optimizing for scarce resources like power, communication capabilities, and payload specialties. Furthermore, this research creates a system that allows for the inclusion and use of diverse, unique platforms and sensor payloads without considerable system modifications. The fleet management system is built on top of NASA’s cFS architecture and includes features from open-source software. A novel optimal control technique, called heterogeneous decentralized receding horizon control is developed and tuning using a UAV simulator. Lastly, exploratory research has been conducted on integrating dynamic vision sensors with UAV flight controllers, to test the integration of novel sensors with this fleet management system. The resulting system is readily deployable and can allow groups like NASA to mimic dynamic, diverse UAV swarms with relative ease.
Shaping Patient Loyalty through Quality Care: Analyzing Patient Satisfaction in Public Hospitals in Ghana

Field: Health Professions (Health Sciences)

Public hospitals in Ghana face challenges such as limited resources and inconsistent care delivery, which impact patient satisfaction and loyalty. In this context, enhancing service quality is crucial for retaining patients and improving healthcare outcomes. This study investigates the role of service quality in shaping patient loyalty and explores patient satisfaction as a mediator in selected public hospitals in Ghana using the SERVQUAL model. A survey was conducted among 200 outpatients from five public health facilities in Kumasi, Ghana, between January and February 25, 2024. A quantitative methodology was applied to evaluate how patients' perceptions of service quality influence their loyalty toward public healthcare providers. In order to analyze the data, SPSS and the smart partial least square (PLS) software version 3.0 were used for structural equation modeling (SEM). The findings revealed that communication, the physical environment, and responsiveness significantly affect patient loyalty, whereas factors such as privacy, safety, and a customer-friendly atmosphere do not. Additionally, this study confirmed that patient satisfaction mediates the relationship between service quality and patient loyalty, underscoring the importance of service quality in enhancing both satisfaction and loyalty in health care. Based on these insights, this study recommends that health care institutions improve their service quality to strengthen public healthcare systems. The significance of this paper extends beyond regression analysis, as it also addresses the delayed effects of service quality on patient loyalty, considering both direct and indirect influences in the regression models.
Plasma Industrial and Ruminant Trans Fatty Acids and Incident Type 2 Diabetes in the EPIC-Potsdam Cohort

Field: Medicine (Health Sciences)

<b>Objective:</b> <p>While dietary intake of trans fatty acid (TFA) is a major public health concern as it raises the risk of cardiovascular events, it remains unclear whether TFA also impact risk of type 2 diabetes and whether industrial TFA and ruminant TFA exert the same effect on health. </p> <p><b>Research Design and Methods:</b></p> <p>To investigate the relation of seven ruminant and industrial TFA, including two conjugated linoleic acids (CLA), plasma phospholipids TFA were measured in a case-cohort study nested within the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam cohort. The analytical sample was a random subsample (n=1,248) and incident cases of type 2 diabetes (n=801) over a median follow-up of 6.5 years. Using multivariable Cox regression models, we examined associations of TFA with incident type 2 diabetes. </p> <p><b>Results:</b> </p> <p>The TFA subtypes were intercorrelated with each other, with other fatty acids, and to different food sources. After controlling for other TFA, the industrial TFA (18:1n-6t, 18:1n-9t, 18:2n-6,9t) were not associated with diabetes risk. Some ruminant TFA subtypes were inversely associated with diabetes risk: vaccenic acid (18:1n-7t, HR per SD 0.72; 95% CI 0.58-0.89) and <i>t</i>10<i>c</i>12-CLA (0.81; 0.70-0.94), while <i>c</i>9<i>t</i>11-CLA was positively associated (1.39; 1.19-1.62). Trans-palmitoleic acid (16:1n-7t) was not associated with diabetes risk when adjusting for the other TFA (1.08; 0.88-1.31). </p> <p><b>Conclusions:</b></p> <p>The TFA conformation plays an essential role in their relationship to diabetes risk. Ruminant TFA subtypes may have opposing relations to diabetes risk. Previous observations for reduced diabetes risk with higher circulating trans-palmitoleic acid are likely due to confounding.</p> <br> <p> </p>
Gene Expression and Pathway Analysis of Quiescent CD8+ T Cells from Liver Cancer, Liver Sinusoid and Peripheral Blood - Study on Toxicogenomics and Prevention Targeting

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The quiescent status of T cell immunology is associated with the development of tumor in liver cancer. However, the cause of T cell quiescence in the tumor microenvironment is still unclear. Recently, it has been proposed that toxic substances could inhibit T-cell immune response to tumor cells. Since sinusoidal structure is primarily involved in anti-toxic function and toxic retaining mechanism, in this paper we study the role of liver sinusoid in liver tumor by comparing gene expression levels of quiescent genes in CD8+ T cells isolated from three sources: peripheral blood, sinusoidal structure, and tumor tissue. We observed that most quiescent genes are up regulated in CD8+ T cells isolated from sinusoidal structure as compared with those from liver tumor and peripheral blood. The genes and pathways predicted in this project will be candidates for drug targeting.
Comparison of the Growth Performance of Three Commercial Hybrid Chicken Varieties Using Grain Based Feeds

Field: Agricultural and Biological Sciences (Life Sciences)

In poultry, feed costs represent a major part of total production costs. Accordingly, improvement of feed conversion ratio; feed intake: weight gain should be a major objective in most breeding programmes. Growth performance of three commercial broiler hybrids in Nigeria were investigated using a total of 60 unsexed day old chicks consisting of 15 each of Rhode Island White, Plymouth Rock and Rhode Island Red; and 15 of the purebred, the Nigerian Southern light ecotype used as control. The breeds were maintained separately in wooden cages of dimension 120cm × 80cm × 40cm at stocking density of 15 birds per m2 and fed for six weeks using broiler starter feed for first four weeks and finisher feed for next two weeks. The broiler starter feed was composed of broiler concentrate (energy Keauka) 2950Kcal, crude protein 2.1%, crude fibre 4.0%, calcium 1.0%, Available phosphorus 0.48%, cysine 1.2% and methionine 0.5%. The finisher’s diet consisted of 1:1.8 mixtures of broiler concentrate and maize meal. No medication was provided during the study. The result showed Rhode Island White had highest maximum weight gain (2874.43% initial weight), Plymouth Rock (1053.14% initial weight) intermediate and Rhode Island Red (986.12% initial weight) lowest. The pure breed weight gain (441.50% initial weight) was lower than the hybrids. Average feed conversion ratio was highest for Rhode Island White (0.394±0.0047), intermediate for Plymouth Rock (0.373± 0.0051) and Rhode Island Red (0.366± 0.0048) next. The difference was significant (P< 0.05). The purebred had the lowest feed conversion ratio (0.346± 0.0047). Rhode Island Red had the lowest mortality (0%), Rhode Island White (6.67%) intermediate and Plymouth Rock next (20%). The purebred had the highest mortality (33.33%). The study showed Rhode Island White was the most economically viable breed due to its higher growth rate, feed conversion ratio and low mortality rate.