jimnoneill/paper-to-field-training huggingface dataset:
Circadian Regulation of Cardiac Arrhythmias and Electrophysiology

Field: Medicine (Health Sciences)

Circadian rhythms in physiology and behavior are ≈24-hour biological cycles regulated by internal biological clocks (ie, circadian clocks) that optimize organismal homeostasis in response to predictable environmental changes. These clocks are present in virtually all cells in the body, including cardiomyocytes. Many decades ago, clinicians and researchers became interested in studying daily patterns of triggers for sudden cardiac death, the incidence of sudden cardiac death, and cardiac arrhythmias. This review highlights historical and contemporary studies examining the role of day/night rhythms in the timing of cardiovascular events, delves into changes in the timing of these events over the last few decades, and discusses cardiovascular disease-specific differences in the timing of cardiovascular events. The current understanding of the environmental, behavioral, and circadian mechanisms that regulate cardiac electrophysiology is examined with a focus on the circadian regulation of cardiac ion channels and ion channel regulatory genes. Understanding the contribution of environmental, behavioral, and circadian rhythms on arrhythmia susceptibility and the incidence of sudden cardiac death will be essential in developing future chronotherapies.
Spectral invariants for monotone Lagrangians

Field: Mathematics (Physical Sciences)

Since spectral invariants were introduced in cotangent bundles via generating functions by Viterbo in the seminal paper [73], they have been defined in various contexts, mainly via Floer homology theories, and then used in a great variety of applications. In this paper we extend their definition to monotone Lagrangians, which is so far the most general case for which a “classical” Floer theory has been developed. Then, we gather and prove the properties satisfied by these invariants, and which are crucial for their applications. Finally, as a demonstration, we apply these new invariants to symplectic rigidity of some specific monotone Lagrangians.
Using micro-climate sensing to enhance RF localization in assisted living environments

Field: Computer Science (Physical Sciences)

In this paper, we propose micro-climate sensing as an effective means of enhancing conventional RF-based localization. Our system targets people-tracking applications in dynamic indoor environments, such as nursing homes, hospitals and office spaces that require simple deployment and where conventional RF-based tracking using signal strengths alone is very likely to suffer from time-varying signal attenuation and inevitable changes in the environment over time such as new furniture arrangements, people traffic, changing obstacle patterns etc. To help mitigate these effects, we use time-synchronized windows of sensor samples to dynamically associate a mobile node with its nearest beacon nodes. Comparisons and matches are always relative to the ambient attributes at the time of localization, and hence our technique automatically evolves with environmental changes. We consider this property of localization techniques to be a significant contribution and a necessary requirement for any long- lived localization system. In assisted-living environments, sensor networks likely already have basic sensors to collect contextual information about users and to monitor the environment. We propose using light, humidity, temperature and audio data samples over a short window of time to model the micro-climate of a beacon node. Using microclimate matching in conjunction with RF signal strength decreases the worst-case localization error significantly by a factor of more than 3 (from 25 m to 8 m) while making the system more resilient to environment changes. Microclimate data helps ensure at least room level location tracking even in buildings like hospitals with many rooms in close proximity.
Do joint national committee VII criteria also need to take non pharmacological measures into consideration? evidence from slum resettlement colony

Field: Medicine (Health Sciences)

Background: Currently Joint National Committee (JNC) VII criteria are used worldwide to d hypertension but it does not take non pharmacological measures into consideration. Also, it does not consider Indian system of medicine. Objectives: To assess whether JNC or revision is required especially for Indian communities where such practices are prevalent. Material and methods: The present community based cross Nagri, a slum resettlement of East Delhi which comes un 2, Issue 1, January, 2015. Empirical
A propensity score‐matched analysis of oncological outcome after systemic therapy for stage IV colorectal cancer: Impact of synchronous ovarian metastases

Field: Medicine (Health Sciences)

Abstract The reported incidence of synchronous and metachronous ovarian metastases (OM) from colorectal cancer (CRC) is ~3.4%. OM from CRC are often considered sanctuary sites due to their lower sensitivity to systemic treatment. It has thus been hypothesized that the presence of OM decreases overall survival. Therefore, the purpose of our study was to evaluate the impact of synchronous OM on overall survival in female patients with stage IV CRC treated with systemic therapy alone with palliative intent. The present study used data from the Netherlands Cancer Registry and included female CRC patients with synchronous systemic metastases who were treated with systemic therapy between 2008 and 2018. A subsample was created using propensity score matching to create comparable groups. Propensity scores were determined using a logistic regression model in which the dependent variable was the presence of OM and the independent variables were the variables that differed significantly between both groups. Our study included 5253 patients with stage IV CRC that received systemic therapy. Among these patients, 161 (3%) had OM while 5092 (97%) had extra‐ovarian metastases only. Three‐year overall survival rates did not show a significant difference between patients with OM compared to patients without ovarian metastases. Moreover, the propensity score‐matched analysis showed that the presence of OM in patients treated with systemic therapy for stage IV CRC disease was not associated with decreased 3‐year overall survival. However, the results of the present study should be interpreted with caution, due to its observational character and used selection criteria.
Parameter Determination of Lithium Titanate Battery for Rail Transit Based on OCV-SOC Characteristic Curve

Field: Energy (Physical Sciences)

The properties of lithium titanate battery for rail transport in different states are tested based on OCV-SOC characteristic curve in order to achieve the homogeneity of rail transit facilities. Here a study case is cited to reveal how about some parameters for battery under test such as the pressure and the capacity, etc. The results show that this approach has a good effect on the lithium titanate battery charge-discharge control with the best voltage limit determined. It is concluded that the best voltage limits for floating charge are favorable for the charge and discharge control of lithium titanate battery in rail transit.
Tools of Brand Promotion Metaverse

Field: Business, Management and Accounting (Social Sciences)

Metaverse is a new immersive technology that is trending to become a new platform for branding, marketing and advertising campaigns. This study is aimed at studying the process of brand promotion in Metaverses, due to limited research on this topic. Majority of the current research is based on analogous virtual spaces, meaning that its data and conclusions may not be fully applicable to Metaverse.This study aims to identify brand promotion tools and study consumer behavioral responses to these tools. The study used a mixed methodology, exploratory design. Qualitative stage of the study involved interviewing experts from Russian marketing agencies that specialize in Metaverse brand integration. The interviews aimed to identify current promotion tools used in the Metaverse industry for brand integration in the Metaverse, as well as identify drivers and barriers encountered by the experts. The quantitative part of the study was an online survey that was conducted among 122 active Russian-speaking Metaverse users. The survey results were usedo the gauge the behavioral and affective reactions of consumers to promotion tools, and also to test he relationship of drivers and barriers of the Metaverse with promotion tools. Based on the results, six main promotion tools were identified, which were divided into two groups: interactive and native. The connections between promotion tools and drivers and barriers were also identified, and the behavioral and affective reactions of users to brand promotion tools in the Metaverse were studied. Two interactive tools (events, bonus system) had stronger correlations with drivers and barriers than two native tools (landscape advertising, product placement). However, one native tool (branded avatar accessories) demonstrated correlations comparable to the two interactive tools. There were no significant differences between interactive and native tools in influencing affective and behavioral responses. However, interactive tools such as bonuses and product testing, and native tools such as branded avatar accessories, were rated as most likely to generate positive consumer reactions.
Wound care in a child suffering from Stevens-Johnson syndrome in PICU: case report

Field: Nursing (Health Sciences)

Stevens-Johnson Syndrome is considered a life-threatening adverse drug reaction. The pathogenesis of these syndromesis still unclear, but several drugs, such as anticonvulsivants and antibiotics, and especially sulfonamides, non-steroidal anti-infiammatorydrugs, and allopurinol were predominantly suspected of triggering this reaction. A 5-year-old boy patient who came to hospital attention for an urticarial reaction developed after taking amoxicillin, then a recent scarlet fever acquired by brother. Due to the worsening of the lesions, he was admitted to our PICU after being intubated for deterioration of the respiratory dynamics and safe treatment of secretions. Nursing care is crucial: care of patient hospitalized with Stevens-Johnson syndrome and Toxic Epidermal Necrolysis consists of wound care, infection prevention, comfort management, hydration and nutrition, psychosocial support, and prevention of long-term complications. For all patients with SJS and TEN, it is essential to perform a total body daily evaluation of the skin. If the dressings remain intact, it is advisable to note the appearance of visible skin and any visible exudate or staining on the outside of the intact dressings. If dressings are being removed or need to be reapplied daily, a full skin evaluation is useful.
Transportation costs of different sizes of cantang hybrid grouper (Epinephelus fuscoguttatus ♀ x Epinephelus lanceolatus ♂) fingerlings

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Cantang hybrid grouper ( Epinephelus fuscoguttatus ♀ x Epinephelus lanceolatus ♂) fry were supplied in many regions in Indonesia through various modes of transportation. The purpose of this study was to evaluate transportation costs against cantang hybrid grouper fry size as consideration for fry users. The research was conducted at one of the grouper hatcheries in Kalianget Village, Banyuglugur District, Situbondo Regency, East Java, Indonesia in December 2019. The hybrid grouper fingerlings were used are 3.0-4.0 cm, 5.0-6.0 cm, 7.0- 8.0 cm, and 9.0-10.0 cm (in total length) were transported from the nursery in Situbondo (East Java, Indonesia) to Medan (North Sumatra, Indonesia) using land and air transportation in 18-20 hours. The results showed that the highest price for grouper fingerlings to the destination was 9.0-10.0 cm of 13,050 IDR and the lowest price for fingerlings of 3.0-4.0 cm of 3,880 IDR. This data can be used as a reference for cantang grouper farmers to determine the most efficient fry size for rearing production.
Academic Engagement and Academic Burnout among Medical Students: Role of Social Support, Academic Self-efficacy, and Self-Esteem

Field: Psychology (Social Sciences)

Active academic engagement in the educational process is instrumental in fostering the potential and self-skills of students, as well as serving as a pathway to acquiring a quality education from academic institutions. Therefore, this study aims to examine role of factorsinfluencing academic engagement with mediators of academic burnout using path analysis through a quantitative design on 249 medical students. In this model test, academic burnout becomes a mediator variable for self-efficacy and social support, while self-esteem is tested directly on academic engagement. The measuring instruments used are UWES-SS, MSPSS, MSLQ, RSE, and MBI-SS which are tested for validity using CFA and Cronbach Alpha reliability. The results showed that academic self-efficacy and social support significantly influence engagement, mediated by burnout, while self-esteem has a direct effect on the variable. These provide further support for existing theories and prior studies, highlighting the significant impact of social support, academic self-efficacy, and self-esteem on academic engagement.
When an expression becomes fixed

Field: Arts and Humanities (Social Sciences)

Abstract This chapter concerns the first person past tense form of the verb ajatella ‘to think’ as a semi-fixed expression in spoken Finnish. We examine this expression in present-day conversation and in older dialect interviews, focusing on its interactional functions, the types of complements it takes, and its patterns of morphosyntactic fixedness and morphophonetic erosion in our two datasets. We show that the verb ajatella is most frequently used in its first person past tense form, mä ajattelin että [1 sg + think- pst -1 sg + comp ] ‘I thought that’, and as has been shown for ‘think’ verbs in many other languages, it is commonly used to frame stance expressions, but another frequent use in our Finnish data is in prefacing the speaker’s expression of her own plans as well as proposals of joint action. Most commonly, mä ajattelin että is followed by clausal complements in our older data, while the complements are more diverse in the newer data, and the expression can also occur without any complements. We also show that while mä ajattelin että ‘I thought that’ occurs in our data in drastically reduced form and shows signs of morphosyntactic fixedness especially in the newer data, it cannot yet be said to have become an epistemic particle.
Microcirculation in Hypertension

Field: Medicine (Health Sciences)

T he number of effective agents available for the treatment of hypertension is now substantial.However, in spite of this, most would agree that there is still considerable scope for improvement in the way hypertension is managed.In many countries, the great majority of hypertensive subjects still show imperfect blood pressure control. 1 Furthermore, the reductions or improvements in end-organ damage seen during antihypertensive therapy do not always correlate well with the reduction in arterial blood pressure achieved.Thus, there seems to be a need for new therapeutic perspectives in the treatment of hypertension.One important new perspective might be provided by an enhanced appreciation of the importance of the microcirculation in the pathophysiology and treatment of hypertension.
Safety and efficacy of a feed additive consisting of Limosilactobacillus reuteri (formerly Lactobacillus reuteri) DSM 32264 as a feed additive for cats (NBF Lanes s.r.l.)

Field: Veterinary (Health Sciences)

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the efficacy of a product consisting of Limosilactobacillus reuteri (formerly Lactobacillus reuteri) DSM 32264 as a zootechnical additive for cats. The additive is a preparation of viable cells of L. reuteri DSM 32264 and it has not been previously authorised as a feed additive in the European Union. The additive is intended for use in complete feed for cats at a minimum inclusion level of 6 × 109 colony forming units (CFU) per animal and day. In a previous opinion, the FEEDAP Panel could not conclude on the efficacy of L. reuteri DSM 32264 for cats. The applicant has provided supplementary information to support the efficacy of the additive for cats. Based on the data provided, the FEEDAP Panel concluded that L. reuteri DSM 32264 has the potential to improve faecal consistency by reducing the moisture content of stools from cats receiving the additive at 1 × 1010 CFU/kg feed. However, the Panel had some reservations on the effects in the moisture content, which if maintained overtime, might cast doubts on the benefits on the long-term use of the additive since it could lead to constipation.
Plant-Based Production of Biosimilar Drug Products

Field: Agricultural and Biological Sciences (Life Sciences)

Most therapeutic antibodies are produced using either Chinese hamster ovary (CHO) or mouse NS0 (myeloma) cells. Despite their relative ease of use and extensive characterization, the use of mammalian cells for producing mAbs has shortcomings. The first demonstration of the successful expression of an IgG in plants was in 1989; since then, improvements in the production of mAbs by plants have contributed to realistic proposals for the use of plant systems as an alternative platform for the production of therapeutic proteins. Plant-based production of recombinant proteins using N. benthamiana is a safe, low-cost, and highly efficient alternative production platform to the standard CHO or NS0 cell culture systems for the production of high-value therapeutic proteins. This chapter illustrates the developmental stages involved in stable transgenic plant production. Improper glycosylation, such as the attachment of truncated N-glycans, causes mAbs to lose their quaternary open Y-shaped structure. The development of biosimilar drugs in plants requires a humanized N-glycosylation system.
Analysis of Performance of Timber Harvesting With the Use of Highlander Harvester

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract The paper presents the work performance analysis of timber harvesting with the use of Highlander harvester produced by KONRAD Forsttechnik GmbH. The analysis was performed based on the timing of the working day. We also assessed the organization of the machine operation in the research area and its functional capability. The study was conducted in Miçdzylesie Forest Department, Nowu Wieś Forestry in fresh mixed mountain forest, where the machine acquired spruce. Timing was perfonned based on the registration of the machine operation on a video camera and the measurements of collected assortment. Based on the results of measurements it was found that organization of the machine operation was not the best. A one-shift work system and short duration of a shift caused that the effective working time occupied only 67.9% of the shift time (about 4 hours). This resulted in reduction of the operating perfonnance on a working day which was only 12,7 m 3 ·h −1 , while an effective high-efficiency was 18.7 m 3 ·h −1 .
Fluidic active flow control of boundary layer separation on supercritical airfoil

Field: Engineering (Physical Sciences)

Presently, during critical phases of flight like takeoff, landing or approach, aircrafts need systems as flaps or slats that helps them to improve lift. Those, hydraulic or mechanical, are deployed during these phases in order to increase the wing surface and consequently, lift. Focusing on the wing, an airfoil is a cross-sectional shape of it; therefore, we can find many configurations or designs with different properties. Specifically, many airplanes use NACA series but, a few years ago, commercial aircraft like Airbus A380 or Boeing 787, or military aircrafts like Boeing C-17 Globemaster are using Supercritical NASA (SC) that improve the global efficiency. In particular, this final degree project is focused on the analysis of the flow on the boundary layer in supercritical airfoil when the airplane is flying at low Reynold numbers. This analysis has been done at different angle of attack in order to analyze the behavior and limits of this airfoil. With this study, basis is established to design a fluidic active flow control with the purpose of reducing aircraft mechanical systems and its problems related with weight, maintenance and failures. For example, when we will be landing at BCN, instead of listen and see a complex system deploying on the wing, we will see a jet on the wing that makes the same effects. Many simplifications have been done possible because we are working at low Reynolds. One of the most important is to work with incompressible flow. Also, an approximation of the supercritical airfoil selected to process and study the behavior is done. About simulations, software like gmsh, Nektar++ or Paraview has been used for the processing to obtain numerical results. Finally, after analyzing simulations results, the optimal angle to deploy the systems is defined. And for this, the fluidic active flow control is going to be implemented to recover the lift.
Impact of Mixtures of Different Fresh‐Cut Fruits on Respiration and Ethylene Production Rates

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Packaging and storage of fresh‐cut fruits and vegetables are a challenging task, since fresh produce continue to respire and senesce after harvest and processing accelerates the physiological processes. The response on respiration and ethylene production rates of fresh produce to changes in O 2 and CO 2 concentrations and temperature has been extensively studied for whole fruits but literature is limited on processed and mixed fresh‐cut fruits. This study aimed to investigate the effects of mixing various proportions of fresh‐cut fruits (melon chunks, apple slices, and pineapples cubes) on respiration and ethylene production rates and to develop predictive models for modified atmosphere packaging. The experiment was designed according to a simplex lattice method and respiration and ethylene production rates were measured at 10 °C. Results showed that single component pineapple cubes, apple slices, and melon chunks, in this order, had significant constant coefficients ( P = 0.05) and the greatest impact on respiration rate while the interactive binary and tertiary coefficients were insignificant. For ethylene production rates, single component apple slices, melon chunks, and pineapple cubes, and their 3‐component mixtures, in this order, had significant constant coefficients ( P = 0.05) while binary coefficients were insignificant. Mathematical models were developed and validated; the cubical model was the best to describe the influence of proportion of fruit on respiration and ethylene production rates, however, considering simplicity the linear part of the model is recommended to quantify respiration and ethylene production rates of mixed fresh‐cut fruits.