jimnoneill/paper-to-field-training huggingface dataset:
Calorimetric Analysis of Triple Helices Targeted to the d(G3A4G3)·d(C3T4C3) Duplex

Field: Chemistry (Physical Sciences)

We present a thermodynamic analysis based on differential scanning calorimetry (DSC) of three short intermolecular DNA triplexes targeted to the same DNA duplex: d(C+3T4C+3)*d- (G3A4G3).d(C3T4C3) (PYR), d(G3A4G3)*d(G3A4G3).d(C3T4C3) (PUR), and d(G3T4G3)*d(G3A4G3).d(C3T4C3) (PUR/PYR). Enthalpies, delta H, and entropies, delta S, are measured by model-free integration of the DSC curves and are compared to the same quantities determined by van't Hoff analysis of the DSC curves and, in the case of the PYR and PUR/PYR triplexes, UV melting curves as well. In the case of the PUR triplex, which exhibits monophasic melting behavior, the calorimetric delta H and the calorimetrically determined van't Hoff delta H are in excellent agreement, indicating an all-or-none transition for this triplex. For the PYR and PUR/PYR triplexes, which melt in a biphasic manner, the calorimetrically determined van't Hoff delta H values are somewhat larger than the model-independent calorimetric delta H values. In those cases, however, good agreement is found between the calorimetric delta H values and the spectrophotometrically determined van't Hoff delta H values. The calorimetrically determined delta H values, expressed per mole of triplet, for the three triplexes are 4.5, 3.8, and 2.4 kcal/mol for the PUR, PYR, and PUR/PYR triplexes, respectively. The same order of stability is observed in terms of delta G and Tm values. The high stability of the PUR triplex at neutral pH indicates that purine oligonucleotides may be the most effective at targeting duplex regions for triple helix formation in vivo.
Abundance ratios of volatile vs. refractory elements: hints of pollutions?

Field: Physics and Astronomy (Physical Sciences)

We present the abundance ratios [X/H] of a large set of chemical species with condensation temperatures from 75 to 1600 K in an almost complete set of 105 planet-host stars and in a volume-limited comparison sample of 88 stars without any known planets. The large range of different Tc covered by all the analysed elements allows us to investigate possible anomalous trends of [X/H] vs. Tc in targets with planets with respect to comparison sample stars. This can give important hints for the detection of pollution events and for the understanding of the relative contribution of the differential accretion to the average metallicity excess found in planet host stars.
Bone as part of skeleton

Field: Medicine (Health Sciences)

The ﬁrst chapter of the book by M. O. Fessenmeyer «Bone: an Element of Diagnostics» presents an analysis of the notions «bone» and «part of skeleton». The author pays special attention to the process of morphogenesis and to the bone modeling capacity, considering a bone as a «living» element, which follows the laws of life. Mechanical and functional qualities of the bone tissue in osteopathic practice are also an object of regard.
Some theory for constructing general minimum lower order confounding designs

Field: Mathematics (Physical Sciences)

General minimum lower order confounding (GMC) is a newly proposed design criterion that aims at keeping the lower order effects unaliased with one another to the extent possible. This paper shows that for 5N/16 < n ≤ N/2, 9N/32 < n ≤ 5N/16, and 17N/64 < n ≤ 9N/32, all GMC designs with N runs and n two-level factors are projections of maximal designs with N/2, 5N/16, and 9N/32 factors, respectively. Furthermore, it provides immediate approaches to construct- ing these GMC designs from the respective maximal designs; these approaches can produce many more GMC designs than the existing computer search method.
Characterization of creatine guanidinium proton exchange by water‐exchange (WEX) spectroscopy for absolute‐pH CEST imaging in vitro

Field: Medicine (Health Sciences)

Chemical exchange saturation transfer (CEST) enables indirect detection of small metabolites in tissue by MR imaging. To optimize and interpret creatine‐CEST imaging we characterized the dependence of the exchange‐rate constant k sw of creatine guanidinium protons in aqueous creatine solutions as a function of pH and temperature T in vitro . Model solutions in the low pH range (pH = 5–6.4) were measured by means of water‐exchange (WEX)‐filtered 1 H NMR spectroscopy on a 3 T whole‐body MR tomograph. An extension of the Arrhenius equation with effective base‐catalyzed Arrhenius parameters yielded a general expression for k sw (pH, T ). The defining parameters were identified as the effective base‐catalyzed rate constant k b,eff (298.15 K) = (3.009 ± 0.16) × 10 9 Hz l/mol and the effective activation energy E A,b,eff = (32.27 ± 7.43) kJ/mol at a buffer concentration of c buffer = (1/15) M. As expected, a strong dependence of k sw on temperature was observed. The extrapolation of the exchange‐rate constant to in vivo conditions (pH = 7.1, T = 37 °C) led to the value of the exchange‐rate constant k sw = 1499 Hz. With the explicit function k sw (pH, T ) available, absolute‐pH CEST imaging could be realized and experimentally verified in vitro . By means of our calibration method it is possible to adjust the guanidinium proton exchange‐rate constant k sw to any desired value by preparing creatine model solutions with a specific pH and temperature. Copyright © 2014 John Wiley & Sons, Ltd.
Locating of normal transitions in a Bi2223 high temperature superconducting coil by using capacitor type voltage terminals and the active power method

Field: Physics and Astronomy (Physical Sciences)

It is important to locate positions of normal transitions in a high temperature superconducting (HTS) coil for identifying its design and fabrication weakness. In this paper, the authors propose a locating method by using capacitor type voltage terminals and the active power method. The former is a method to measure voltage in a HTS coil without electric contact and the latter is a method to detect the normal transitions by measuring active power dissipated in the coil. Combination of the two methods can achieve precise location of the normal transitions. The authors show usefulness of the method through experimental results for a Bi2223 HTS coil.
Detecting air travel to survey passengers on a worldwide scale

Field: Computer Science (Physical Sciences)

Market research in the transportation sector is often based on traditional surveys, such as travel diaries, which have well-documented shortcomings and biases. The advent of mobile and wireless technologies enables new methods of investigation of passengers’ behaviour that can eventually provide original insights into mobility studies. Because these technologies can capture travellers’ experience in context and real time, they pave the road for new survey methods. In this article, we demonstrate that mobile phones can recognise air travel with a light algorithm that scans their connectivity to cellular networks. The originality of our method is that it does not rely on any Global Positioning System-like location information and runs on a large variety of mobile phones. It detects flights on a worldwide scale and asks travellers to report on their travel experiences as they occur, eliminating the recall bias of traditional solutions. Once the system detects a journey, it triggers a flight satisfaction questionnaire that sends answers to a centralised server. This approach respects the traveller's privacy and proved a 97% success rate in detecting flights in a 12-months study involving six travellers who boarded on 76 planes.
An Efficient Framework for EEG Analysis with Application to Hybrid Brain Computer Interfaces Based on Motor Imagery and P300

Field: Computer Science (Physical Sciences)

The hybrid brain computer interface (BCI) based on motor imagery (MI) and P300 has been a preferred strategy aiming to improve the detection performance through combining the features of each. However, current methods used for combining these two modalities optimize them separately, which does not result in optimal performance. Here, we present an efficient framework to optimize them together by concatenating the features of MI and P300 in a block diagonal form. Then a linear classifier under a dual spectral norm regularizer is applied to the combined features. Under this framework, the hybrid features of MI and P300 can be learned, selected, and combined together directly. Experimental results on the data set of hybrid BCI based on MI and P300 are provided to illustrate competitive performance of the proposed method against other conventional methods. This provides an evidence that the method used here contributes to the discrimination performance of the brain state in hybrid BCI.
The patient with asthma: implications for dental practice.

Field: Dentistry (Health Sciences)

A history of asthma is reported commonly by adult dental patients and may be more prevalent in children. An acute episode of asthma in the dental office may be precipitated by extrinsic factors such as inhaled allergens, as well as intrinsic factors such as fear or anxiety. An asthma episode should be considered a medical emergency and must be treated promptly by inhalation of a bronchodilating agent. A history of asthma in the dental patient should alert the dentist to implement strategies that may prevent an acute attack and to be prepared to manage this potentially life-threatening medical emergency appropriately. The chronic use of bronchodilating inhalers and/or glucocorticoids for the management of asthma can increase the likelihood of oral candidiasis, particularly in patients who have additional risk factors such as smoking, denture use, or the use of xerostomic medications.
Massive Gauge Bosons in Yang-Mills Theory without Higgs Mechanism

Field: Physics and Astronomy (Physical Sciences)

Two kinds of Yang-Mills fields are found upon the concepts of mass eigenstate and nonmass eigenstate. The Yang-Mills fields of the first kind were proposed by Yang and Mills, which couple to the mass eigenstates with the same rest mass, whose gauge bosons are massless. I find that there are second kind of Yang-Mills fields, which are constructed on a five-dimensional manifold. Only the nonmass eigenstates couple to the Yang-Mills fields of the second kind, which are the nonmass eigenstates as well and composed of mass eigenstates of gauge bosons. The mass eigenstates of the Yang-Mills fields of the second kind live in the four-dimensional spacetime, the corresponding gauge bosons of which may be massive. The SU(2)\times U(1) gauge fields of the second kind are studied carefully, whose gauge bosons, which are the mass eigenstates, are the W^{\pm}, Z^{0} and photon fields. The rest masses of W^{\pm} and Z^{0} obtained are the same as that given by the Glashow-Salam-Weinberg model of electroweak interactions. It is discussed that this model should be renormalizable.
The Mexican Revolution, 1910-1914: The Diplomacy of Anglo-American Conflict.

Field: Social Sciences (Social Sciences)

Preface Maps Introduction Part I. Revolution: 1. Diaz 2. The Fall of Diaz 3. Madero Part II. Counter-revolution: 4. Recognition 5. Indecision 6. Decision 7. Indiscretion 8. Non-recognition Conclusion Bibliography Index.
Parkinson's Disease: Long-Term Results of Levodopa Therapy

Field: Medicine (Health Sciences)

The long-term results of levodopa therapy in Parkinsonian patients is described. Between January 1969 and December 1972, dopaminergic therapy was started in 186 patients with Parkinson's disease. Their progress after six months, five years and in the autumn of 1980, was assessed. The initial benefit in the majority of patients was followed by a gradual loss of efficacy in most patients with increasing side effects of central-mediated type. We suggest that it may be wise to delay the onset of levodopa therapy until progress of the disease makes treatment imperative.
A geospatial framework for mapping of electromagnetic radiations

Field: Environmental Science (Physical Sciences)

The electromagnetic radiations from the various electronic equipments, such as transmitters for broadcasting of radio/TV and mobile communication, are the major sources of electromagnetic pollution. This is creating a potential hazard for public health. This work aims at mapping the electromagnetic field over population map through open geospatial standards. This may facilitate proper management of man-made electromagnetic radiations and monitoring of public health.
Impacts of bank mergers on shareholder's wealth

Field: Economics, Econometrics and Finance (Social Sciences)

We examine the effect of the news about merger of six banks into four major banks, employing the standard event study method with the market model on a sample of four bidders and six target banks. We find significant impact of merger announcement on the bidder and target banks. While the bidder banks are negatively impacted, the target banks experience positive impacts on the event day and day after, followed by negative results later on. No previous study is found to have addressed this question on how the merger announcements impact the bidder and target bank's stock returns in India.
Artifacts of the CGO 2024 Paper: EasyTracker: A Python Library for Controlling and Inspecting Program Execution

Field: Computer Science (Physical Sciences)

This is the archive of the artifacts for the CGO 2024 Paper "EasyTracker: A Python Library for Controlling and Inspecting Program Execution" The EasyTracker library is an open source project, refer to the Home page and Gitlab repository for up-to-date versions: Home Page: https://corse.gitlabpages.inria.fr/easytracker Repository: https://gitlab.inria.fr/CORSE/easytracker The details of the artifacts generation are described in the paper appendix or in the README.md file included in the main artifacts archive easytracker-artifacts-cgo-2024-v1.2.0.tar.gz. Summary of artifacts construction steps (execution in a Docker container): ensure Docker is installed with docker --version, download the artifacts archive easytracker-artifacts-cgo-2024-v1.2.0.tar.gz, extract with tar xvzf easytracker-artifacts-cgo-2024-v1.2.0.tar.gz, change dir with cd eastracker-artifacts-cgo-2024, download the EasyTracker sources archive easytracker-archive-dfe8aa888f.tar.gz, extract with tar xvzf easytracker-archive-dfe8aa888f.tar.gz, download the docker image docker-image-easytracker-1.2.0.tar, load the Docker image with docker load -i docker-image-easytracker-1.2.0.tar, generate all artifacts with ./in-docker.sh ./run-all.sh, all artifacts are generated in figure-*/ directories, refer to the artifacts archive README.md file for more details, or refer to the paper artifacts appendix. Note that this artifacts archive is extracted from the artifacts repository at tag v1.2.0: https://gitlab.inria.fr/CORSE/easytracker-artifacts-cgo-2024/-/tree/v1.2.0
RADT-13. EARLY CONCURRENT IMMUNOTHERAPY WITH STEREOTACTIC RADIOSURGERY IS ASSOCIATED WITH PROLONGED SURVIVAL AND DECREASED DISTANT BRAIN FAILURE IN PATIENTS WITH NEWLY DIAGNOSED MELANOMA BRAIN METASTASES (MBM)

Field: Medicine (Health Sciences)

Abstract INTRODUCTION We evaluated outcomes of patients with newly diagnosed MBM treated with concurrent immune checkpoint inhibition (ICI) and stereotactic radiosurgery (SRS) (concurrentTx), defined as treatment delivery within 30 days of each other. METHODS Screening of 2,617 melanoma patients who received ICI (anti-CTLA4/anti-PD1/both) between 2011-2019 identified 151 pts who received concurrentTx for MBM. Among these, 51 had newly-diagnosed MBM and received no prior ICI or SRS, and were included in the current study. Overall survival (OS) and distant brain failure (DBF) were estimated using the Kaplan-Meier method. Incidence of radiation necrosis (RN) was captured. RESULTS Median follow up from treatment initiation (either ICI or SRS, whichever occurred first) was 37 months. Median OS was 30 months. Median interval between ICI/SRS was 12 days (range: 1-29). Twenty-two patients received ICI first and 29 received SRS first, without differences in OS (p=0.22), DBF (p=0.91), or development of RN (p=0.86). However, the interval between ICI and SRS was significant. Patients who received concurrentTx 1-11 days apart (n=25, “early”) experienced a significant improvement in OS and DBF compared to 12-29 days apart (n=26, “delayed”) (p=0.01, HR 2.8; 95%CI 1.3-6.2 for OS and p=0.02, HR 2.5; 95%CI 1.2-5.6 for DBF). OS and DBF at 36 months were 67% vs. 26% and 60% vs. 27%, respectively, for the early vs. delayed groups. Time to concurrentTx as a continuous variable was significantly associated with DBF (p=0.02), but not OS (p=0.06). Although not significant, more patients developed RN in the early (26.0%) versus delayed (3.8%) group (p=0.07). No additional patient or treatment differences were identified. CONCLUSIONS Early concurrentTx was associated with prolonged OS and improved DBF in newly diagnosed MBM patients who did not receive prior CNS-directed therapy. This finding suggests therapeutic synergism related to combined early treatment and should be validated in a prospective clinical trial.
Duality of Orthogonal and Symplectic Matrix Integrals and Quaternionic Feynman Graphs

Field: Mathematics (Physical Sciences)

We present an asymptotic expansion for quaternionic self-adjoint matrix integrals. The Feynman diagrams appearing in the expansion are ordinary ribbon graphs and their non-orientable counterparts. The result exhibits a striking duality between quaternionic self-adjoint and real symmetric matrix integrals. The asymptotic expansions of these integrals are given in terms of summations over topologies of compact surfaces, both orientable and non-orientable, for all genera and an arbitrary positive number of marked points on them. We show that the Gaussian Orthogonal Ensemble (GOE) and Gaussian Symplectic Ensemble (GSE) have exactly the same graphical expansion term by term (when appropriately normalized),except that the contributions from non-orientable surfaces with odd Euler characteristic carry the opposite sign. As an application, we give a new topological proof of the known duality for correlations of characteristic polynomials. Indeed, we show that this duality is equivalent to Poincare duality of graphs drawn on a compact surface. Another application of our graphical expansion formula is a simple and simultaneous (re)derivation of the Central Limit Theorem for GOE, GUE (Gaussian Unitary Ensemble) and GSE: The three cases have exactly the same graphical limiting formula except for an overall constant that represents the type of the ensemble.
Green Product Supply Chain Coordination Under Demand Uncertainty

Field: Decision Sciences (Social Sciences)

The problem of coordinating a two-echelon green product supply chain with environmentally conscious consumers under demand uncertainty is studied in this paper. In the green product supply chain, a manufacturer produces green product through developing green technology and a retailer promotes the green product through green marketing. The demand of the green product is uncertain with the mean and the variance as the only known information. After analyzing the utility that a consumer gained from the green product, the problem is then formulated as a distribution-free-based Stackelberg game for a decentralized system under three contracts, i.e., wholesale price-only (WPO), revenue and green marketing cost-sharing (RGMS), and two-part tariff (TPTF) contracts. The analytical results are also proposed to show the effects of the system parameters on supply chain optimal decisions. By comparing with the centralized system, the coordination level for each contract is investigated. Numerical examples and sensitivity analysis with respect to several system parameters are presented to illustrate the effectiveness of the contracts under demand uncertainty. The results demonstrate that both RGMS and TPTF contracts are superior to WPO contract. Especially, TPTF contract can always coordinate the supply chain, while RGMS contract can improve the supply chain coordination level only if the revenue and cost sharing coefficients satisfy certain conditions.
Effect of Illumination Supplement on Growth of Tomato Plantlets

Field: Agricultural and Biological Sciences (Life Sciences)

Tomato was used as experiment material. The effectt of different illumination supplements on growth and sucrose metabolism was investigated. The results showed that height and fresh weight were different due tto light quality. This difference was more evident during the growth prophase of plantlets (the firstt 12 days). In most of the growth phase, the contents of sucrose and protein, and invertase activity in leaves with the supplementt of red light were higher than those with the supplement of white light.
Biopsychosocial Health Education Dynamics of Rape Perpetration: A Rape Prevention Dynamics

Field: Health Professions (Health Sciences)

Rape perpetration is a public health concern and most cases of rape are less reported possibly because of shame, fear of attack or poorly enforced legal action. Series of attempts to curb and reduce the cases of rape especially in Nigeria involved some measures of incarceration and social supports. Traditional methods of treating individual with healthcare needs that foster wellbeing was basically a physician biomedical approach. Overtime, health was viewed as a holistic concept incorporating not only biological domain and causes of illness but also other dimensions including psychological and social. Therefore, a more comprehensive and holistic approach incorporating the biological, psychological and social determinants of individual’s health and wellbeing evolved. Such an approach is more encompassing in health education and disease prevention. Hence, the biopsychosocial health education dynamics of rape perpetration becomes a veritable tool for explaining the drives behind rape perpetration of sexually active males. Therefore, a number of theories including the biological theory, Rape Theory and the Social Learning Theory were used to explain the biological, psychological and social health education dynamics of rape perpetration. Finally, the Psychoanalytic Theory of Sigmund Freud and Ellis’s Biosocial Theory were used to provide explanations for the biopsychosocial health education dynamics of rape perpetration with particular focus on the dynamics of prevention of the behaviour.
Studies on Physiological Characteristics of Cut Freesia Flowers During Vase Holding

Field: Agricultural and Biological Sciences (Life Sciences)

The cut flowers of Freesia hybrida 'Shangnong Jinhuanghou' were used as materials to study their phenotype changes and their physiologic response during vase holding.The results showed the vase life of an individual flower and a whole inflorescence was less than one week and 10 days, respectively.The contents of natural water and soluble protein in the petals increased at the early stage of vase holding,and then decreased 4 days later.The activities of superoxide dismutase (SOD),catalase (CAT)and ascorbate peroxidase(APX)increased in preceding stage,and decreased rapidly in later stage. However,the activity of peroxidase(POD)increased with the time postponing of vase holding.The content of superoxide radical (O2-)was accumulated during vase holding.Meanwhile,the malondialdehyde(MDA) content and the electrolyte leakage increased with the process of vase holding.The water loss,the decrease of activities of antioxidant enzymes and the accumulation of O2- and rising of lipid peroxidation level were considered to be the main physiological causes of senescence of cut Freesia flowers.