jimnoneill/paper-to-field-training huggingface dataset:
NMR-Guided Mass Spectrometry for Absolute Quantitation\nof Human Blood Metabolites

Field: Chemistry (Physical Sciences)

Broad-based, targeted\nmetabolite profiling using mass spectrometry\n(MS) has become a major platform used in the field of metabolomics\nfor a variety of applications. However, <i>quantitative</i> MS analysis is challenging owing to numerous factors including (1)\nthe need for, ideally, isotope-labeled internal standards for each\nmetabolite, (2) the fact that such standards may be unavailable or\nprohibitively costly, (3) the need to maintain the standards’\nconcentrations close to those of the target metabolites, and (4) the\nalternative use of time-consuming calibration curves for each target\nmetabolite. Here, we introduce a new method in which metabolites from\na single serum specimen are quantified on the basis of a recently\ndeveloped NMR method [Nagana Gowda\net al. Anal. Chem. 2015, 87, 706] and then used as references for\nabsolute metabolite quantitation using MS. The MS concentrations of\n30 metabolites thus derived for test serum samples exhibited excellent\ncorrelations with the NMR ones (<i>R</i><sup>2</sup> >\n0.99)\nwith a median CV of 3.2%. This NMR-guided-MS quantitation approach\nis simple and easy to implement and offers new avenues for the routine\nquantification of blood metabolites using MS. The demonstration that\nNMR and MS data can be compared and correlated when using identical\nsample preparations allows improved opportunities to exploit their\ncombined strengths for biomarker discovery and unknown-metabolite\nidentification. Intriguingly, however, metabolites including glutamine,\npyroglutamic acid, glucose, and sarcosine correlated poorly with NMR\ndata because of stability issues in their MS analyses or weak or overlapping\nsignals. Such information is potentially important for improving biomarker\ndiscovery and biological interpretations. Further, the new quantitation\nmethod demonstrated here for human blood serum can in principle be\nextended to a variety of biological mixtures.
Re-Examining the Effect of Quarterly Reporting on Firm Value—New Evidence from the Introduction of a Risk-Based Approach in Singapore

Field: Business, Management and Accounting (Social Sciences)

ABSTRACT Kajüter, Klassmann, and Nienhaus (2019) (KKN) find that mandating quarterly reporting is net costly for small firms. In this study, we re-examine the firm value effect of quarterly reporting using Singapore’s regulatory change from a size-based to a risk-based approach to quarterly reporting, in which only high-risk firms are mandated to report quarterly. We find that prior mandatory quarterly reporters do not react significantly to the regulatory relaxation. However, firms with a strong demand for transparency and small firms previously exempted from quarterly reporting react significantly negative (−0.83 and −1.67 percent, respectively). Consistent with KKN, high-risk firms that are now required to report quarterly perceive the mandate as burdensome (−2.80 percent). Moreover, firms exhibit heightened uncertainty after the announcement of the regulatory change until the publication of high-risk firms. Finally, quarterly reports of high-risk firms do not generate information spillovers to nonquarterly reporters, whereas those of voluntary continuers do so. JEL Classifications: M41; M48.
Catheter ablation of ventricular tachycardia in patients with postinfarction left ventricular aneurysm

Field: Medicine (Health Sciences)

Abstract Background While ventricular tachycardia (VT) in the setting of postmyocardial infarction left ventricular aneurysms (LVA) is not uncommonly encountered, there is a scarcity of data regarding the safety, efficacy, and outcomes of ablation of VT in this subset of patients. Methods Our study included consecutive patients aged 18 years or older with postmyocardial infarction LVA who presented to Mayo Clinic for catheter ablation of VT between 2002 and 2018. Results Of 34 patients, the mean age was 70.4 ± 9.1 years; 91% were male. Mean LVEF was 29 ± 9.7% and left ventricular end‐diastolic dimension was 64.9 ± 6.6 mm. The site of the LVA was apical in 21 patients (62%). Fifteen patients (44%) presented with electrical storm or incessant VT. Nine patients (26%) had a history of intracardiac thrombus. All except for one patient had at least one VT originating from the aneurysm. The mean number of VTs was 2.9 ± 1.7. All patients underwent ablation at the site of the aneurysm. Ablation outside the aneurysm was performed in 13 patients (38%). Low‐voltage fractionated potentials and/or late potentials at the aneurysmal site were present in all cases. Complete elimination of all VTs was achieved in 18 (53%), while the elimination of the clinical VT with continued inducibility of nonclinical VTs was achieved in a further 11 patients (32%). Two patients developed cardiac tamponade requiring pericardiocentesis. During a mean follow‐up period of 2.3 ± 2.4 years, 11 patients (32%) experienced VT recurrence. Freedom from all‐cause mortality at 1‐year follow‐up was 94%. Conclusion Radiofrequency catheter ablation targeting the aneurysmal site is a feasible and reasonably effective management strategy for clinical VTs in patients with postinfarction LVA.
Peripheral Vascular Lesion in Diabetes Mellitus

Field: Medicine (Health Sciences)

This report gives the results of a histological study of the blood-vessels of the skin of the leg; amputated limbs and skin biopsies were examined and the findings were then correlated with the results of previous clinical assessment.Lesions of the feet occur much more commonly in diabetics than in non-diabetics.Bell (1957), in a necropsy series of 52,062 cases, found that the incidence of gangrene was increased 53 times in male diabetics and 71 times in females.It used to be assumed that the cause was a greater liability
Randomized, placebo-controlled, adjunctive study of armodafinil for bipolar I depression: implications of novel drug design and heterogeneity of concurrent bipolar maintenance treatments

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Some, but not all, prior investigations suggest armodafinil may have utility as an adjunctive treatment in bipolar I depression.Multicenter, randomized, double-blind study in patients aged 18 to 65 years experiencing a depressive episode despite maintenance therapy for bipolar I disorder. Patients were randomized to receive adjunctive armodafinil 150 mg/day or adjunctive placebo for 8 weeks. Primary efficacy outcome was change from baseline in 30-Item Inventory of Depressive Symptomatology-Clinician-Rated (IDS-C30) total score at week 8. Safety and tolerability were monitored.Of 656 patients screened, 399 were randomized, of whom 308 (77 %) were taking a protocol-allowed mood stabilizer as monotherapy. The primary efficacy outcome did not reach statistical significance; however, several secondary efficacy outcomes demonstrated statistically significant advantages for adjunctive armodafinil (n = 197) over adjunctive placebo (n = 196), including Clinical Global Impression of Severity of Illness for depression (weeks 6, 8, and endpoint; all P < 0.05), Global Assessment of Functioning (weeks 4, 8, and endpoint; all P < 0.02), IDS-C30 remitter rates (week 8 and endpoint; both P < 0.02), and mean change from baseline in IDS-C30 total score at week 7 (P < 0.05). Adjunctive armodafinil and adjunctive placebo were generally well tolerated. Although adjunctive armodafinil compared with adjunctive placebo yielded a higher headache rate (15 vs 8 %), it yielded similar (generally favorably low) rates of all-cause discontinuation (16 vs 16 %), adverse event discontinuation (4 vs 5 %), nausea (6 vs 4 %), ≥7 % weight gain (2 vs 5 %), anxiety (4 vs 3 %), insomnia (3 vs 2 %), sedation/somnolence (1 vs 1 %), and hypomania (0 vs <1 %).In this study, adjunctive armodafinil compared with adjunctive placebo in bipolar I depression did not separate in the primary efficacy outcome but demonstrated advantages for several secondary efficacy outcomes and was generally well tolerated. Additional research is warranted and necessary to better identify clinical predictors (e.g., atypical depressive symptoms, specific anti-manic/mood-stabilizing agents used) that would provide optimized, individualized therapeutics for bipolar depression.ClinicalTrials.gov: NCT01305408.
Teacher Research Experiences, Partnerships With Scientists, and Teacher Networks Sustaining Factors From Professional Development

Field: Social Sciences (Social Sciences)

This study examined some long-term impacts of a professional development program, Teachers in the Woods. Several outcomes of the program were acknowledged by participants as having been valuable: a network of like-minded teachers, a network of scientists and teachers, and an increase in teachers' ecological knowledge and field skills. The authors made 3 observations with regard to professional development. First, engaging teachers in real-world field science research is an effective way for them to gain ecological knowledge and skills. Second, the collegiality among teachers and scientists developed during the period of field work can enhance science learning. Third, collegiality among teachers provides opportunities to discuss pedagogy-related issues. Both aspects of collegiality provide support mechanisms that sustain teachers' efforts to modify their teaching practices.
Policy interventions for technological innovation in developing countries

Field: Economics, Econometrics and Finance (Social Sciences)

This paper assesses the potential social pay off of alternative measures that might be taken to promote innovation in LDCs. It is mainly concerned with the general issues of encouraging technical innovation in the nonagricultural sectors. However, it also is focused on the more particular but important question of how to generate innovations that lead to new techniques of production which are better suited than existing ones to the social objectives of employment and greater equality in the distribution of income. Part 1 discusses the process of innovation and describes the skills associated with it. Part 2 sets forth some of the special problems that developing economies encounter in building up innovative skills. Part 3 draws together some of the main implications for policy and explains how priorities for the development of local innovative activities might be determined. Part 4 analyzes the patterns of innovative activity that might be needed in developing economies. Part 5 summarizes the main conclusions and suggests some of the implications of adopting an approach that stems from these conclusions.
On bartlett and bartlett-type corrections francisco cribari-neto

Field: Mathematics (Physical Sciences)

This paper reviews the literature on Bartlett and Bartlett-type corrections. It focuses on the corrections to the likelihood ratio, score and Wald test statistics. Three different Bartlett-type corrections which are equivalent to order n-1, n being the sample size, are compared through simulation. One of the forms displayed superior behavior both in terms of size and power. We also use Monte Carlo simulation to examine the effect of independent variables and the impact of the number of nuisance parameters on the finite-sample behavior of some asymptotic econometric criteria in regression models.
Effects of Relative Cohort Size on Inequality and the Overall Structure of Wages

Field: Economics, Econometrics and Finance (Social Sciences)

Abstract This chapter analyzes the wages at all age levels throughout the workforce. It tries to identify whether the age structure of the population has had a significant effect on the primary dimensions of inequality in the United States over the last thirty-five years: on the return to experience, the return to skill, hours and weeks worked, and on the general structure of wages and level of inequality. Changing relative cohort size can explain a significant proportion of the variation over time in measures of work intensity, such as hours and weeks worked and the proportion working full time, at all levels of experience. Cohort size effects—on wages, unemployment, and hours and weeks worked—have occurred not just among younger workers, but throughout the labor force. Furthermore, changing relative cohort size has been a major factor increasing all types of inequality in the society over the past few decades.
Sir Harold Ridley (1906–2001): televising and filming ophthalmic surgery and eye examinations

Field: Medicine (Health Sciences)

Sir Harold Ridley is well known for his pioneering intraocular lens implantation surgery. He also had a significant commitment to the televising and filming of surgery. In his 1950 Television in Ophthalmology paper, Ridley describes the techniques he used to capture his surgery in monochrome and later in full colour for audiences at St Thomas' Hospital.
Improvements in magnetic depth estimation: application of depth and width extent nomographs to standard depth estimation techniques

Field: Earth and Planetary Sciences (Physical Sciences)

We describe an example of a common geological scenario which results in magnetic bodies of limited depth extent. We then present examples of the errors in depth estimates, as high as 40% or more, incumbent in the use of many classic magnetic depth techniques when considering bodies of limited depth extent. Then using interpretation by characteristics applied to generalized dyke models we develop correction nomographs for a wide variety of classic magnetic depth techniques. We show the improvements in depth estimation that are obtained using our nomographs when applied to the ideal dyke model as well as a conceptualized passive margin cross-section model. We use the principle of isostatic equilibrium to develop one simple methodology for estimating magnetic crustal thickness in the absence of a priori information. We then demonstrate the effectiveness of these techniques by application to the 3D Bishop magnetic model. We show that by using reasonable geological assumptions one can develop acceptable first-pass estimates of the maximum thickness of magnetic bodies, which are key to accurate depth estimates. Using estimates of crustal thickness and applying appropriate thickness corrections based on the developed nomographs, errors of up to 40% in depth estimation can be reduced to a few per cent under ideal assumptions of isolated bodies and absence of noise.
The New Democratic Revolution in Music during the Play Experience of Ideological and Political Education Function

Field: Computer Science (Physical Sciences)

After a deep investigation on the maximum terms space of the clause set, the concept of the partial maximum terms space of the clause set, which the maximum terms of the clause set decomposed, is brought forward.By investigating the extension rule, this paper introduces the concept of the satisfiability and the unsatisfiability of the partial maximum terms space, and gives an algorithm determining the satisfiability of a partial space of the maximum terms -algorithm PSER (Partial Semi-Extension Rule).Then, the TP problem is decomposed into several sub-problems independent of each other, which can be solved by the given parallel computing method PPSER (Parallel Partial Semi-Extension Rule).
refusing Ginkgo

Field: Medicine (Health Sciences)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GRADUATES’ EXPECTATION IN RELATION TO THE BIOMEDICINE COURSE AND THEIR INSERTION IN THE LABOR MARKET

Field: Health Professions (Health Sciences)

INTRODUCTION: The Biomedical Scientist is prepared for the exercise of numerous activities related to the area, today there are 35 qualifications duly established and regulated by the Federal Council of Biomedicine (CFB) ensuring this performance. Since then the course has expanded and broken national boundaries, so there is also the course in Bahia, especially in the extreme Baiano. MATERIALS AND METHODS: This is a study of perception, carried out with field research with the use of data survey through questionnaires applied to undergraduate students in the year before the SARS-Cov-2 Pandemic. RESULTS AND DISCUSSION: The answers of 63 students were evaluated, and separated according to each question, 33% of the students have the knowledge that for the profession there is still no defined wage cap, needing more regulations with the CFB, 86% of the students did not know that they can act in the Strategy and Health of the Family (ESF), in the vaccination area and acupuncture, at the time to the research 64% of the sample did not exercise paid activity, what facilitates the non-obligatory internship that according to the questioned ones should begin in the 3rd semester. CONCLUSION: Thus, through the study of the students' knowledge of the course, it is clear that health care becomes more complex and the biomedicine student should be trained in a broader way, having contact with discussions in other areas.
Remodeling of the composition of the membrane�s lipids of buckwheat plants (Fagopyrum esculentum Moench.) under conditions of phosphorous deficiency and seed bacterization with phosphate solubilizing microorganisms

Field: Agricultural and Biological Sciences (Life Sciences)

This paper presents research results on the sensitivity of buckwheat (Fagopyrum esculentum Moench.) inoculated with phosphate solubilizing microorganisms (PSM) to phosphorus deficiency using the transformation of major photosynthetic tissues membrane lipids as the indicator. The analysis of glyco- and phospholipids performed has revealed the plants’ ability to react to a deficit in phosphorus with the selective accumulation of sulfoquinovosyldiacylglycerol (SQDG) and digalactosyldiacylglycerol (DGDG) along with a decrease in phosphatidylglycerol (PG). Pre-sowing seed bacterization with PSM has balanced out the negative impact of a phosphorus deficiency on plants by stabilizing the PG content and reducing the difference in the PG/SQDG ratio.
Collaborative performing arts---InterPlay

Field: Arts and Humanities (Social Sciences)

InterPlay is a telematic collaborative event where two or more sites, utilizing Access Grid technology, perform simultaneously across the globe. The performances are concurrently captured, mixed, digitized, encoded and streamed onto Internet 2.Dancing on the Banks of Packet Creek is an exploration into the tenuous curiosity that we have towards the inundating wave of digital information. Packet Creek depicts the Internet with its flow of disassembled pieces of data that course throughout the world like schools of spawning salmon. Dancing on the Banks is our ritualistic gyrations that we express as we create, disseminate, search, and acquire this electronic epistemological knowledge.Using the metaphor of fluid motion and dynamics we will creatively explore the expansive range between truth and fiction or frivolity and importance through music, dance, video, computer graphics and remote motion capture MIDI control.
Using Data Mining to Predict Soil Quality after Application of Biosolids in Agriculture

Field: Environmental Science (Physical Sciences)

The amount of biosolids recycled in agriculture has steadily increased during the last decades. However, few models are available to predict the accompanying risks, mainly due to the presence of trace element and organic contaminants, and benefits for soil fertility of their application. This paper deals with using data mining to assess the benefits and risks of biosolids application in agriculture. The analyzed data come from a 10‐yr field experiment in northeast France focusing on the effects of biosolid application and mineral fertilization on soil fertility and contamination. Biosolids were applied at agriculturally recommended rates. Biosolids had a significant effect on soil fertility, causing in particular a persistent increase in plant‐available phosphorus (P) relative to plots receiving mineral fertilizer. However, soil fertility at seeding and crop management method had greater effects than biosolid application on soil fertility at harvest, especially soil nitrogen (N) content. Levels of trace elements and organic contaminants in soils remained below legal threshold values. Levels of extractable metals correlated more strongly than total metal levels with other factors. Levels of organic contaminants, particularly polycyclic aromatic hydrocarbons, were linked to total metal levels in biosolids and treated soil. This study confirmed that biosolid application at rates recommended for agriculture is a safe option for increasing soil fertility. However, the quality of the biosolids selected has to be taken into account. The results also indicate the power of data mining in examining links between parameters in complex data sets.
Giant cell tumor of bone: Report of three cases with unusual locations

Field: Medicine (Health Sciences)

International Journal of Case Reports and Images (IJCRI)International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.
Star formation in collisional ring galaxies and the circumnuclear regions of active galactic nuclei

Field: Physics and Astronomy (Physical Sciences)

This dissertation contains multiwavelength observational projects on collisional ring galax­ ies. active galactic nuclei (AGNs). and neutral hydrogen observations of the collisional ring galaxy Arp 118 (an interacting pair NGC 11-14/1143). I have demonstrated in my dissertation research that: starburst knots of individual colli­ sional ring gala.xies cluster around the same, very young age suggesting that their formation was recently triggered by a coherent event all around the ring and strongly supports their pro­ duction as a result of the passage of a radial density wave: the atomic and molecular emission in the strongly interacting gala.xy .\rp 118 appears to be very asymmetrically distributed such that the .WV region of the gala.xy is mainly atomic hydrogen, whereas the SE region has an interstellar medium which is ~94% molecular hydrogen. One possiblity is that in the SE region there is a rapid conversion of HI to H). which may be a result of the highly off-center collision between .\GC 1144 and .\GC 1143: and the global far-infrared colors of Seyfert galaxies may be linked to their radio morphologies.