jimnoneill/paper-to-field-training huggingface dataset:
In vitro and in vivo studies of cyclic di-GMP signaling proteins

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Cyclic di-GMP is a bacterial secondary messenger important for the regulation of biofilm formation and bacterial pathogenesis. Although much progress has been made in recent years, many questions about the hierarchical and complex cyclic di-GMP signaling networks remain to be answered. With only a relatively small number of cyclic di-GMP signaling proteins, Bacillus subtilis serves as a simple and genetically tractable model organism for us to study cyclic di-GMP signaling. We identified two catalytically active diguanylate cyclases (DGC), one phosphodiesterase (PDE) and one bifunctional enzyme. Phenotypic analysis revealed the regulatory roles of these proteins in bacterial motility, sporulation and biofilm formation. In addition, a few representative GGDEF-EAL didomain proteins with known input signals were nvestigated to understand how the GGDEF or EAL domain is regulated by its associated N-terminal regulatory domain. The catalytic activities of the AxDGC2 and AxPDEA2 proteins from Gluconacetobacter xylinus were found to be modulated by the flavin and heme-associated PAS domain respectively; while the Tbd_1269 protein from the Thiobacillus denitrificans was found to possess both DGC and PDE activities that are likely to be regulated by phosphorylation of the N-terminal regulatory domain.
Effects of the bioactive amino acids leucine and tryptophan on feed intake in layer chicks

Field: Agricultural and Biological Sciences (Life Sciences)

Controlling feed intake is essential to providing ideal nutrition and helping poultry reach their maximum potential for growth and development. The current research looked at how L-leucine and L-tryptophan affected layer chicks' meal intake. Leucine and tryptophan were administered intracerebroventricularly (ICV) to 4-day-old layer chicks, and feed intake was monitored at different time intervals. Our findings demonstrated that L-leucine administration by ICV enhanced feed intake up to two hours after treatment (P 0.05). On the other hand, L-tryptophan (10 or 100 g) had no discernible impact on feed consumption. These results showed that L-leucine may impact appetite inside the hypothalamus and that orexigenic and anorexigenic Neuropeptide genes may be directly involved in these effects.
Ophthalmometry without patient fixation.

Field: Medicine (Health Sciences)

Because of the asphericity of the cornea, proper ophthalmometry requires the visual axis of the eye, the optical axis of the ophthalmometer, and the corneal apex to be coincident. The animal subject and the human patient cannot always direct their visual axis to the axis of the instrument. This paper describes the attachment of a photographer's tripod pan arm to the Haag Streit ophthalmometer and the method devised, which allows accurate corneal curvature measurement in cases of nonfixating subjects.
Selected Examples of Obscure Narrators in Musnad Imam Ahmad Musnad Al-Qabail: Collecting and Investigating

Field: Arts and Humanities (Social Sciences)

ABSTRACT It is well- recognized for intellectuals that Sunnah is the second legislative source after the Holy Qur’an. Islamic nation is marked by its legislative system that follows and preserves what is left from its Prophet’s instructions. This study aims at highlighting obscure narrators in Musnad of Imam Ahmad, the Musnad of the tribes, by collecting the methods of each of selected hadiths in which there was a vagueness in order to enlighten the knowledge of the obscure narrator.
FP3.1 Risk of Subsequent Hip Arthroscopy Following Isolated Femoral Derotational Osteotomy

Field: Medicine (Health Sciences)

Abstract Background Femoral version abnormalities are an underrecognized cause of hip pain and joint damage, and in the appropriate patient, can be treated with femoral derotational osteotomy (FDO). The need for arthroscopy following isolated FDO remains unknown. This study aimed to determine the risk of subsequent hip arthroscopy after FDO, the mean time to intervention, and survivorship free of further arthroscopy. Methods A consecutive series of patients who underwent isolated FDO by a single surgeon in a mature hip preservation practice were retrospectively reviewed. Patients with history of prior ipsilateral hip surgery were excluded. Demographics, need for subsequent surgery, pre- and postoperative femoral version, and modified Harris Hip Scores (mHHS) were collected. Survivorship was calculated using Kaplan-Meier analysis. Results A total of 134 hips underwent isolated FDO. Fifty-one patients with a history of prior surgery were excluded. Of the included 83 hips (88% female, mean age 27.3 ± 8.6 years, mean follow-up 4.3 ± 4.5 years), 67% were treated for excessive femoral anteversion and 33% for excessive retroversion. Four hips (4.8%) required subsequent hip arthroscopy at an average of 4 ± 3.7 years (range, 1.1 to 9.4) for pain attributed to an untreated labral tear. Survivorship free of subsequent hip arthroscopy was 100%, 96.1%, and 93.4% at 1-year, 3-years, and 5-years, respectively. 88% of hips underwent removal of femoral hardware after a mean of 1.2 years. There was significant pre- to postoperative improvement in mHHS among all cases (59.7 +/- 10.8 to 85.8 +/- 13.2, p &lt; 0.001). Conclusion While the majority (95.2%) of hips that underwent isolated FDO for excessive femoral version did not require subsequent arthroscopy, those that did underwent the procedure at an average of 4 years following the index procedure. Survivorship free of subsequent hip arthroscopy following isolated FDO was 100%, 96.1%, and 93.4% at 1-year, 3-years, and 5-years, respectively. This data demonstrates that for the majority of patients, treating the anatomic deformity appears to result in satisfactory pain relief, though a small subset may need subsequent treatment for labral pathology.
The Potential Criminal Adversaries of Nuclear Programs: A Portrait,

Field: Social Sciences (Social Sciences)

This paper examines the possibility that terrorists or other kinds of criminals might attempt to seize or sabotage a nuclear facility, steal nuclear material, or carry out other criminal activities in the nuclear domain which has created special problems for the security of nuclear programs. This paper analyzes the potential threat. Our tasks was to describe the potential criminal adversary, or rather the spectrum of potential adversaries who conceivably might carry out malevolent criminal actions against nuclear programs and facilities. We were concerned with both the motivations as well as the material and operational capabilities likely to be displayed by various categories of potential nuclear adversaries.
Impact of Low Light on Photosynthetic Characteristics, Antioxidant Activity, and Yield of Brassica napus L.

Field: Agricultural and Biological Sciences (Life Sciences)

Low light is an abiotic stress that has a significant impact on crop growth. However, the impact of low light on rapeseed yield has not been well documented. Our study aims to examine the potential effects of low light on the photosynthesis antioxidant capacity and yield composition of leaves by simulating low light environments. According to the study results, low light reduces key photosynthetic enzymes and sucrose synthase activity in rapeseed leaves, leading to a decrease in leaf carbohydrate accumulation. The reduced number of pods per plant and the number of pods per grain are the direct factors leading to the decrease in rapeseed grain yield, while the increase in grain weight compensates for some of the yield loss. In addition, low light increased the content of malondialdehyde in leaves and altered the activities of catalase (CAT) and superoxide dismutase (SOD). Low light inhibits photosynthesis in leaves, reduces leaf productivity, and leads to a decrease in yield. High-yielding varieties have stronger antioxidant capacity and lower production of malondialdehyde. By revealing the effects of low light on the photosynthesis and antioxidant capacity of rapeseed leaves, this studyprovide new insights into the composition of low light affecting rapeseed grain yield and explain significant guidance for the planting and management of different rapeseed varieties in low light areas.
Jaspers, Karl (1883–1969)

Field: Arts and Humanities (Social Sciences)

Abstract Karl Jaspers (1883–1969) was an existentialist philosopher, deeply influenced by Kant, Kierkegaard, and Max Weber, whose philosophy formed a subjectivist counterpart, within the existentialist movement, to the fundamental ontology of Martin Heidegger. His works exercised great influence in a number of theoretical fields in Germany in the middle years of the twentieth century. He began his career as a psychiatrist, and published enduringly influential works in this field: notably his General Psychopathology (1913). The major philosophical publication of his philosophical career was the three‐volume work Philosophy (1932), which attempted to fuse Kantian and Hegelian ideas to provide an account of the experiential formation of human consciousness. In this work, he analyzed consciousness as proceeding from the level of immediate knowledge and progressing through a sequence of antinomies toward a level of truthfully unified reflection and self‐knowledge. Also of philosophical importance are Jaspers's interventions in religious debate. The central idea in Jaspers's philosophy of religion is the concept of philosophical faith , in which he promoted a critical‐recuperative attitude toward religious inquiry and attempted to convert elements of religious doctrine into a (secularist) account of human possibilities and freedoms. The ambition behind his work on religion and myth was to liberate transcendent knowledge from theology, and to permit an interpretive transformation of religiously conceived essences into aspects of human self‐interpretation.
Synthesis and Characterization of Zinc Phosphates in Aqueous and Non-Aqueous Media with (2-Hydroxyethyl) Trimethyl Ammonium Hydroxide as Template

Field: Chemistry (Physical Sciences)

Zinc phosphate molecular sieve were synthesized using zinc chloride, phosphoric acid as a zinc and phosphor source, respectively. Different types of zinc phosphates zeolites were synthesized by conventional hydrothermal (using (2-hydroxyethyl) trimethylammonium hydroxide (2-HETMAOH) as new template. Also, ethylene glycol (EG) was utilized as co-solvent and ultrasonic tool was applied as mixer. The influence of the chemical composition of the starting sol-gel and the other parameters such as, Zn/P mole ratio, time of microwave irradiation were studied.
Pendampingan Asesmen Pembelajaran Dalam Implementasi Kurikulum Merdeka Pada SMAN 13 Takalar

Field: Social Sciences (Social Sciences)

The learning assessment on implementing the independent curriculum aims to determine student learning outcomes' needs, developments, and achievements. This activity aims to assist teachers at SMAN 13 Takalar regarding learning assessments in implementing the independent curriculum. The methods of implementing the activities are training and advocacy. The training method uses lecture, discussion, and practice techniques. The advocacy method uses presentation, dialogue, and negotiation techniques. The analysis technique used is descriptive statistics. The results of the activities indicated: 1) the training participants had a high level of ability to absorb knowledge and apply learning assessments, 2) the problems faced by the participants could find solutions to solve them, and 3) the advocacy results provided enlightenment for stakeholders at SMAN 13 Takalar in implementing assessment policies according to the conditions of the academic unit. The next activity is the recommendation to hold training regularly and optimize the role of the community of practitioners in schools to share good practices.
Effect of hydroprocessing severity on characteristics of jet fuel from OSCO 2 and Paraho distillates

Field: Energy (Physical Sciences)

Jet A boiling range fuels and broad-property research fuels were produced by hydroprocessing shale oil distillates, and their properties were measured to characterize the fuels. The distillates were the fraction of whole shale oil boiling below 343 C from TOSCO 2 and Paraho syncrudes. The TOSCO 2 was hydroprocessed at medium severity, and the Paraho was hydroprocessed at high, medium, and low severities. Fuels meeting Jet A requirements except for the freezing point were produced from the medium severity TOSCO 2 and the high severity Paraho. Target properties of a broad property research fuel were met by the medium severity TOSCO 2 and the high severity Paraho except for the freezing point and a high hydrogen content. Medium and low severity Paraho jet fuels did not meet thermal stability and freezing point requirements.
Momentous Explored Gap in Entrepreneurial Self Efficacy an Observational Study *S.Jegadeeswari

Field: Business, Management and Accounting (Social Sciences)

This study is aimed to identify the research gap in the entrepreneurial research regarding the self efficacy of entrepreneurs. The researcher has reviewed twenty nine articles from eighty two entrepreneurial study based articles. Observations made on the variables on self efficacy and the momentous explored gap was identified that entrepreneurial self efficacy and its impact on the sustainability in their business. The supportive reviews were observed and depicted in this article.
Effects of Climate Change on Communities Living and Economic Structure of Indus Riverine Areas of Dera Ghazi Khan

Field: Social Sciences (Social Sciences)

Climate change is the most important issue of the top current issues that the globe is experiencing. Climate change is the most significant and hazardous issue not just for Pakistan but globally as well. Pakistan is one of the underdeveloped nations in South Asia and is ranked among the five nations that have been worst affected by climate change. Climate change has severely influenced both the development of human lifestyles and existence, together with food scarcity, wildlife destruction, and risky meteorological conditions problems. The objectives of the study were (1) to investigate the direct consequences of deforestation on the local ecosystem and (2) to examine how deforestation increases environmental changes. The study was delimited to people only in the Indus riverine areas in District Dera Ghazi Khan. All the people who are living in the Indus Riverine areas in District D.G. Khan served as the population of the study. A total sample size of 225 citizens was selected from District Dera Ghazi Khan. In the first stage, 3 Tehsils of District Dera Ghazi Khan e.g. (Dera Ghazi Khan, Kot Chutta, & Taunsa Shareef) were selected. In the second stage, 3 riverside union councils were selected from each Tehsil through a convenient sampling technique. In the third stage, 25 citizens were selected from each union council. Data was collected through an interview schedule and examined by ‘The Statistical Package for Social Sciences’ (SPSS). Obtained results indicate that climate change also happens in the community (99.1%), climate change decreases the local agricultural productivity (92.9%) and climate change has effect on the overall economic sustainability of the local community (95.5%). The bivariate analysis showed that more will be climate change vs less will be the agricultural productivity; less will the economic sustainability. So, all the hypothesis results are accepted after the analysis of the data.
Some functional properties of oilseed proteins

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Oilseeds have potential food uses because of their high protein content. Besides, these proteins when added to a type of foods, supply desirable functional properties, such as whipping capacity and viscosity, emulsification and water and oil holding capacities. Rapeseed and soybean protein isolates were found to possess whipping capacity followed by those of sunflower, peanut, sesame, cottonseed and safflower. The addition of sugar improved the whipping properties of oilseed proteins. The whipping capacity of oilseed proteins decreased due to heating at 100°C for time of 15 to 60 min. Soybean protein had the highest emulsifying capacity compared with the other oilseed proteins. The heated oilseed proteins had emulsification properties similar to or better than the control. Glandless cottonseed protein had high water and oil holding capacities. The water holding capacity of oilseed proteins decreased gradually as the duration of heating at 100°C was increased. On the other hand the heated oilseed proteins had oil holding capacities similar to or better than umheated proteins.
Anharmonic Effect on Unimolecular Reactions with Application to the Photodissociation of Ethylene

Field: Chemistry (Physical Sciences)

The importance of anharmonic effect on dissociation of molecular systems, especially clusters, has been noted. In this paper, we shall present a theoretical approach that can carry out the first principle calculations of anharmonic canonical and microcanonical rate constants of unimolecular reactions within the framework of transition state theory. In the canonical case, it is essential to calculate the partition function of anharmonic oscillators; for convenience, the Morse oscillator potential will be used for demonstration in this paper. In the microcanical case, which involves the calculation of the total number of states for the activated complex and the density of states for the reactant, we make use of the fact that both the total number of states and the density of states can be expressed in the inverse Laplace transformation of the partition functions and that the inverse Laplace transformation can in turn be carried out by using the saddle-point method. We shall also show that using the theoretical approach presented in this paper the total number of states and density of states can be determined from thermodynamic properties and the difference between the method used in this paper and the thermodynamic model used by Krems and Nordholm will be given. To demonstrate the application of our theoretical approach, we chose the photodissociation of ethylene at 157 and 193 nm as an example.
Inhibition of p38 MAPK Signalling Impairs the Homing of B Lineage ALL Cells to the Bone Marrow of NOD/SCID Mice.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract The mechanisms regulating the migration of B lineage acute lymphoblastic leukemia (ALL) cells between the blood and bone marrow compartments remain obscure. The chemokine SDF-1 regulates the motility and proliferation of ALL cells in vitro. We have previously demonstrated that the chemotaxic response of these cells to SDF-1 requires signalling through p38 MAPK and that signalling through PI-3K and MEK/ERK pathways plays only a minor role in a subset of cases. This contrasts with normal CD34+ hematopoietic progenitors and CD34+CD19+ B cell progenitors where signalling through PI-3K is the predominant pathway required for chemotaxis. In this study we examined the requirement for SDF-1 and p38 MAPK signalling in the homing of the B lineage ALL cells to the bone marrow of NOD/SCID mice. CFSE-labelled ALL cells were pre-treated with either the specific CXCR4 antagonists AMD3100 (100μM) or TC14012 (100μM), the p38 MAPK inhibitor SB203580 (10μM), the AKT inhibitor LY294002 (6.65μM) or the MEK inhibitor PD98059 (20μM) for 0.5–1 h at 37°C. Control or inhibitor treated cells were then injected intravenously into irradiated NOD/SCID mice which were either pre-treated with control (vehicle) or the inhibitors AMD3100 (200μg/mouse), TC14012 (200μg/mouse), SB203580 (0.1 mg/mouse), the AKT inhibitor LY294002 (2 mg/mouse) or the ERK inhibitor PD98059 (0.2 mg/mouse). Homing was assessed 4 hours after the injection of cells before significant proliferation of homed cells could occur. AMD3100 and TC14012 significantly inhibited the homing of ALL cells to the bone marrow by up to 80% and 67% respectively. Inhibition of p38 MAPK also decreased the homing of ALL cells to the bone marrow of NOD/SCID mice by 40% compared with the DMSO controls (p<0.05). No inhibition of homing was observed with the inhibitors of PI-3K or MEK in ALL cells. These results support our previous in vitro findings with regards to the importance of the p38 MAPK pathway in SDF-1 induced motility of ALL cells and demonstrate that the same pathway plays an essential role in the homing of these cells to the bone marrow of NOD/SCID mice.
THE POTENTIAL USE OF Ca(NO3)2 TO IMPROVE SALINITY TOLERANCE IN DATE PALM (Phoenix dactylifera L.)

Field: Agricultural and Biological Sciences (Life Sciences)

The study was conducted to investigate the impact of Ca(NO3)2 on different levels of salt-stress in date palm. Three-years-old date palm plants were subjected to four NaCl levels: 50, 100, 150 and 200 mM. The saline solutions were supplemented with 0, 5, 10 and 20 mM Ca(NO3)2. The combined NaCl/Ca(NO3)2 treatments were conducted over a period of 10 weeks. Control plants were only subjected to the four salinity levels with no Ca (NO3)2 addition. Results showed an inhibitory effect of salinity on almost all plants' parameters under investigation, mainly the accumulation of ions such as N, K, Ca, plant dry weight, chlorophyll and net photosynthesis rate. Addition of Ca (NO3)2 in the solution was more beneficial when added in a moderate concentration (10 mM) compared to lower (5 mM) and higher (20 mM) under all salinity levels. The addition of 10 mM Ca (NO3)2 noticeably enhanced chlorophyll content under 50 mM Na Cl (2.5 mg/100 cm2) and 150 mM NaCl (2 mg/100 cm2). In addition, 10 mM Ca (NO3)2 reduced the accumulation of Na and Cl in plant parts. For instance, in trees subjected to 10 mM Ca (NO3)2, Cl content in leaves and stems under 50 mM Na Cl were 0.23% and 0.65%, respectively. On the other hand, Cl content under 100 mM Na Cl and 200 mM Na Cl were lower compared to their corresponding control treatments. It seems that the use of Ca (NO3)2 had ameliorative effects on salt-stressed date palm plants when used with moderate concentrations.
Effects of adding video feedback to emotionally focused therapy supervision: A concurrent multiple‐baseline across subjects design

Field: Psychology (Social Sciences)

Abstract Emotionally focused therapy (EFT) is an empirically supported intervention for relationship distress with an established model of supervision. This study examined whether incorporating video feedback (VF) software into EFT supervision would improve therapists' level of development compared to traditional EFT supervision in a university training clinic. A concurrent multiple‐baseline across subjects design, along with a thematic analysis of qualitative data, were used in this proof‐of‐concept study of the new supervision component. Overall, quantitative findings suggested that using VF in EFT supervision resulted in some improvement to therapists' development, while qualitative findings showed that all participants supported the incorporation of VF into EFT supervision. Future research on VF is needed to provide additional insight into the use of video review supervision.