jimnoneill/paper-to-field-training huggingface dataset:
Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKα Phosphorylation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Alternative NF-κB signaling is crucial for B cell activation and Ig production, and it is mainly regulated by the inhibitor of κ B kinase (IKK) regulatory complex. Dysregulation of alternative NF-κB signaling in B cells could therefore lead to hyperactive B cells and Ig overproduction. In our previous, study we found that deleted in breast cancer 1 (DBC1) is a suppressor of the alternative NF-κB pathway to attenuate B cell activation. In this study, we report that loss of DBC1 results in spontaneous overproduction of Ig in mice after 10 mo of age. Using a double mutant genetic model, we confirm that DBC1 suppresses B cell activation through RelB inhibition. At the molecular level, we show that DBC1 interacts with alternative NF-κB members RelB and p52 through its leucine zipper domain. In addition, phosphorylation of DBC1 at its C terminus by IKKα facilitates its interaction with RelB and IKKα, indicating that DBC1-mediated suppression of alternative NF-κB is regulated by IKKα. Our results define the molecular mechanism of DBC1 inhibition of alternative NF-κB activation in suppressing B cell activation.
Determination of the Compressive Strengths of Resin Composite and Glass-Ionomer Based Materials

Field: Dentistry (Health Sciences)

Bu in vitro çalışmada, rezin kompozit ve cam iyonomer esaslı restoratif materyallerin basma dayanıklılıkları araştırıldı.4 mm çapında 6 mm yüksekliğindeki materyal örnekleri Delrin® kalıplar içerisinde hazırlandı.Tüm deneysel işlemler oda sıcaklığında gerçekleştirildi.Farklı rezin kompozitler (Esthet-X, Z250, Ceram-X, TPH ve Siloran), poliasit modifiye rezin kompozit (Compoglass F), rezin modifiye cam iyonomer (Photac Fil Quick Aplicap) ve konvansiyonel cam iyonomer siman (Ketac Molar Quick Aplicap) test edildi.Materyallerin basma dayanıklılıkları üniversal test cihazında tespit edildi.Elde edilen veriler tek yönlü ANOVA ve takiben Bonferroni testi ile analiz edildi (p=0,05).Rezin kompozitlerin basma dayanıklılıkları arasındaki farklılıklar anlamlı bulundu (p<0,05).En yüksek basma dayanıklılığı Z250'den en düşük ise Ketac Molar Quick Aplicap'dan elde edildi.Bir geçiş materyali olarak Compoglass F, rezin kompozitlerin bazılarından (p<0,05) ve konvansiyonel cam iyonomer simandan (p<0,01) farklı direnç değerleri sergiledi.Konvansiyonel ve rezin modifiye cam iyonomer simanların basma dayanıklılıkları arasındaki
Familial haemophagocytic lymphohistiocytosis

Field: Medicine (Health Sciences)

Haemophagocytic lymphohistiocytosis (HLH) is a rare, but potentially fatal, disease that occurs when normal histiocytes and lymphocytes become overactive and commonly occurs in infancy. Two forms of the disease have been described: primary and secondary. This article reports twins who were less than 2 years old at the time of presentation and who had clinical symptoms of primary (familial) HLH, which was diagnosed by a contributory pathological bone marrow test.
Effects of Emotional and Spiritual Intelligence on Job Performance among Temporary Nurses at Abdul Riva’i Regional General Hospital, Berau District, East Kalimantan Province, Indonesia

Field: Health Professions (Health Sciences)

This study examined the effect of emotional and spiritual intelligence on performance of temporary nurses at the Regional General Hospital of Berau District East Kalimantan Province, Indonesia. It also investigated the mediating role of organisational commitment on the relationship between emotional and spiritual intelligence on the performance of these nurses. Survey data collected from 129 respondents was examined using the Structural Equation Modeling (SEM) technique utilising AMOS version 22.0 software. Emotional intelligence and spiritual intelligence was found to have positive and significant effects toward organisational commitment. Subsequently, organisational commitment has positive and significant effects on temporary nurses’ performance and positively mediates the relationship between emotional intelligence and spiritual intelligence on temporary nurses’ performance. The results of this study can assist hospital administrators in Indonesia to look into improving the temporary nurses’ performance by focusing on their organisational commitment. It is also pertinent for them to understand the role of emotional intelligence and spiritual intelligence when undertaking action to strengthen the nurses’ organisational commitment.
Choosing the Right Color: A Way to Increase Sales

Field: Business, Management and Accounting (Social Sciences)

It can be stated that the colors are one of the most important and powerful tools of design for marketing materials such as web sites, direct mail, ads, and etc. Meanings and Usage of Color can vary from country to country. Therefore, it is necessary to identify each culture color psychology for correct use of color. This paper focuses on the psychological meaning of each color and suggests using it in the correct position. To this purpose the relationship between color and culture, gender, emotions and Costumer behavior are expressed. Findings of the study indicate that managers, Graphics’ designer and advertisers can use colors for increase Customer attention, and then use it to increase sales.
In Vitro Analysis of Interactions Between Staphylococcus aureus and Pseudomonas aeruginosa During Biofilm Formation

Field: Immunology and Microbiology (Life Sciences)

Staphylococcus aureus and Pseudomonas aeruginosa are classified as ESKAPE pathogens that present a significant challenge to treatment due to their increased resistance to a considerable number of antimicrobial agents. Background/Objective: Biofilms exacerbate treatment challenges by providing enhanced antimicrobial and environmental protection. Mixed-species biofilms further complicate treatment options through numerous complex interspecies interactions, leading to potentially severe adverse clinical outcomes. Methods: This study assessed the interaction between clinical S. aureus and P. aeruginosa isolates during biofilm formation using microplate biofilm formation assays, scanning electron microscopy, and confocal microscopy. Results: We identified a competitive relationship between P. aeruginosa and S. aureus, where both pathogens exhibited a reduction in biofilm formation during mixed-species biofilms compared with monocultures, although P. aeruginosa outcompeted S. aureus. Furthermore, we found that the cell-free conditioned media (CFCM) of P. aeruginosa significantly reduced the S. aureus biofilms. Using fractioned CFCM, we identified that the anti-staphylococcal activity of the >10 kDa fraction was almost identical to the non-fractioned CFCM. Our confocal microscopy results suggest that P. aeruginosa CFCM depolarize S. aureus membranes and reduces the biofilm burden. Conclusions: These findings contribute to our understanding of the mechanisms underlying the interactions between these pathogens, suggesting that there is an antagonistic relationship between S. aureus and P. aeruginosa in a biofilm setting.
Evaluation of the operational capabilities of a new extrathoracic negative pressure device for use in newborn infants.

Field: Health Professions (Health Sciences)

We evaluated the operational capabilities of a new negative pressure incubator from Chelmsford, England prior to its use in our Neonatal Intensive Care Unit (NICU). Successful manufacturer's testing had already been completed. Teams of respiratory therapists and a biomedical engineer evaluated two identical units using 22 criteria, and results were scored on a pass/fail basis. The device passed our evaluation; we found it to be well built and reliable, with a wide range of rate, inspiratory time, peak negative inspiratory pressure and negative expiratory extrathoracic pressure settings. It did not pass criteria involving pressure monitor reliability, pressure relief, suction unit alarms, ease of service and service manual. This device may be used as a ventilator for intubated or non-intubated infants, in tandem with positive pressure mechanical ventilation replacing positive end-expiratory pressure with negative end-expiratory pressure, or alone in the continuous negative extrathoracic pressure mode.
Protection of Nuclear Power Plants from Fraudulent Items

Field: Engineering (Physical Sciences)

At present a lot of problems with fraudulent items occurred. They disrupt the safety of industry, power engineering and other objects that are important for the life of human society. The article gives infor-mation on causes of occurrence of fraudulent items in nuclear power plants and shows that protection against fraudulent items needs to perform during the whole supply chain of critical items. In detail, it concentrates to the quality of awarding terms of references, which nuclear power plant operator prepares when it gives order to commercial supplier and of process of take-over control of the deliver commodity. Due to national security, the safety of nuclear facilities is also supervised by national nuclear regulatory body. During our research we processed checklists by which national nuclear regulatory body can reveal risks in awarding the contracts to commercial suppliers and in take-over control, and ensures improve-ment of these processes.
Shady Grove Site (22QU525) Quitman County, Mississippi: Analysis of Demographics and Mortuary Practices

Field: Arts and Humanities (Social Sciences)

The Mississippian Period (A.D. 1000-1500) is distinguished by reliance on stable agriculture, sedentary ranked populations, and production of prestige goods. Sociopolitical structure was based on kinship, wealth, and power, and can be revealed through the local mortuary programs. This thesis explores the mortuary practices observed at an ossuary at Shady Grove (22QU525), a small mounded center in Quitman County dating to the Early Mississippian Period, based on demographics, burial mode, cemetery location, and associated grave goods. The Burial 43 ossuary, excavated in 2010 contained stacked bundle burials of at least 78 individuals. All age groups and both sexes were present. There were 22 artifacts recovered, including 12 shell tempered vessels and a copper ornament. There were both collective offerings to the entire group and several artifacts interred with two individuals, which may indicate they were persons of higher status. It is unclear if the ossuary contains a single kin group or a sample of the entire population, which would indicate that everyone was allotted equal access to both locally produced and trade items. The observed difference in the burial method of stacked burials and its location under Mound B shows the variability of mortuary practices during this time period in the region. The information gained from this study will help in the understanding of the sociopolitical organization of smaller chiefdoms in the Mississippi Delta and Lower Mississippi Valley.
Effect of Fabrication-Dependent Shape and Composition of Solid-State Nanopores on Single Nanoparticle Detection

Field: Materials Science (Physical Sciences)

Solid-state nanopores can be fabricated in a variety of ways and form the basis for label-free sensing of single nanoparticles: as individual nanoparticles traverse the nanopore, they alter the ionic current across it in a characteristic way. Typically, nanopores are described by the diameter of their limiting aperture, and less attention has been paid to other, fabrication-dependent parameters. Here, we report a comprehensive analysis of the properties and sensing performance of three types of nanopore with identical 50 nm aperture, but fabricated using three different techniques: direct ion beam milling, ion beam sculpting, and electron beam sculpting. The nanopores differ substantially in physical shape and chemical composition as identified by ion-beam assisted cross-sectioning and energy dispersive X-ray spectroscopy. Concomitant differences in electrical sensing of single 30 nm beads, such as variations in blockade depth, duration, and electric field dependence, are observed and modeled using hydrodynamic simulations. The excellent agreement between experiment and physical modeling shows that the physical properties (shape) and not the chemical surface composition determine the sensing performance of a solid-state nanopore in the absence of deliberate surface modification. Consequently, nanoparticle sensing performance can be accurately predicted once the full three-dimensional structure of the nanopore is known.
An Enriched Customer Journey Map: How to Construct and Visualize a Global Portrait of Both Lived and Perceived Users’ Experiences?

Field: Computer Science (Physical Sciences)

Design is about understanding the system and its users. Although User Experience (UX) research methodologies aim to explain the benefits of a holistic measurement approach including explicit (e.g., self-reported) and implicit (e.g., automatic and unconscious biophysiological reactions) data to better understand the global user experience, most of the personas and customer journey maps (CJM) seen in the literature and practice are mainly based on perceived and self-reported users’ responses. This paper aims to answer a call for research by proposing an experimental design based on the collection of both explicit and implicit data in the context of an authentic user experience. Using an inductive clustering approach, we develop a data driven CJM that helps understand, visualize, and communicate insights based on both data typologies. This novel tool enables the design development team the possibility of acquiring a broad portrait of both experienced (implicit) and perceived (explicit) users’ experiences.
POMPEIU PROBLEM FOR COMPLEX ELLIPSOIDS ON THE HEISENBERG GROUP

Field: Mathematics (Physical Sciences)

We extend results of the Pompeiu problem on the Heisenberg group H from spheres to complex ellipsoids. These results also tell us what happens for spheres and complex ellipsoids on the anisotropic Heisenberg group, Ha . The results for L , L, and L have the same character as previous results for spheres on H. However, when moving to L and including rotations, we maintain the result from Euclidean space that only one complex ellipsoid is needed.
Clinical Experience in the Operating Room

Field: Nursing (Health Sciences)

The formal classes are followed by eight weeks of actual operating room experience which is assigned during the first months of the second year. We find that this method helps the student to (1) understand the basis for aseptic technique and its application to nursing service in general, (2) give better nursing care to patients before the operation and following the operation as a result of being a member of the operating room team, (3) realize the necessity of working as a team member with others, and recognize that cooperation is the keystone in any type of nursing service, (4) develop the ability to organize, to anticipate the surgeon's needs as he operates, and to act quickly when necessary. When the student goes to the operating room for her experience there she has a background of knowledge in safety, economy, and asepsis which ave been taught by the same person who does the clinical teaching. The medical residents are especially helpful in the learning situation, and are always eager to help her add to her knowledge of anatomy throughout the surgical procedures. During the first week the student learns how to scrub, put on gloves and gown, and how to handle instruments. After learning to scrub, she prepares the stock table and sutures. The clinical instructor holds informal classes on the various types of operating tables, lights, and electrical equipment, how to drape tables, and the care of specimens. Later in the week the student circulates first with the clinical instructor and then alone. She attends informal classes on draping the patient, folding linen, and the care of needles, sterile and unsterile supplies, and suture materials. During the second week, the student assists the surgeon during the operation by passing instruments and preparing sutures. And, from the third through the eighth week, she gains experience in the various clinics, such as bronchoscopic, cystoscopic, gynecologic, orthopedic, and eye, ear, nose, and throat. She gets experience in maintaining supplies and setting up clinics while she spends one week on the 4 to 12 shift and one on the 12 to 8 shift. The student is evaluated by all of the graduate nurses in the operating room for her ability to plan nursing care, for her skillfulness, sense of responsibility, coordination of activity, character, and personality. The nurses use anecdotal records for this
Japanese Society and Cultural Policies of Traditional Play

Field: Social Sciences (Social Sciences)

This research aims to identify social transformation and cultural policies regarding traditional play in the Japanese society.BR The civilization and enlightenment policy of the Meiji government was westernization. The government politically cracked down on the people’s recreational habit of gambling, which encouraged diminishment of traditional play. Meanwhile, the authority focused on fostering strong soldiers by promoting western sports.BR As imperialism rose and the people’s interest in traditional culture deepened, the Japanese emperor engaged in himself and reproduced traditional play by establishing Kemari Preservation Society. BR Moreover, martial activities were modernized: Jujitsu to Judo, fencing to kendo, and archery to kungdo(archery). Traditional tug-of-war was designated as a major program in school sports days. BR While Japanese culture was on a fast track towards westernization, modern sports began to gain interest as a new leisure activity. Nonetheless, the Matsuri festival was preserved and reproduced regionally with the theme of traditional play for almost 10 years since the 1950s.BR As the Japanese people’s desire for leisure prevailed thanks to the economic revival, the government worked on developing leisure activities as a part of its cultural policies. One example was supporting the local Matsuri festival; it promoted the cultural policy that concentrated on forming solidarity among residents.
Creating Florida's Multilingual Global Work Force: Educational Policies and Practices for Students Learning English as a New Language.

Field: Social Sciences (Social Sciences)

A selection of essays address issues in the education of students of asp Second Language in Florida, focusing on the development of the state's labor force among this multilingual, multicultural population. Papers include: Implications of Demographic Changes in Florida's Public Population (Thomas D. Boswell); Issues in the Education of Florida's Language Learners (Sandra H. Fradd, Diane K. Wilen, Diane Fardig); Literacy Development for Language Enriched through Language Arts (Fradd); School Mathematics for Language Enriched Pupils (Walter G. Secada); Science Instruction and Assessment for Language Enriched in the State of Florida (Okhee Lee); Social Studies Instruction and Assessment: Meeting the Needs of Students Learning English (Deborah J. Short); and Promoting the Contributions of Multicultural Students in the Work Force of the 21st Century (Eugene E. Garcia). (MSE) ******************************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. ********************************************************************************
The role of Fast spin-echo T2-weighted and diffusion-weighted imaging for spine bone marrow changes evaluation in postmenopausal women with osteoporosis

Field: Medicine (Health Sciences)

Abstract Background To prospectively investigate the role of Fast spin-echo T 2 -weighted (FSE T 2 -w) and diffusion-weighted imaging (DWI) in magnetic resonance imaging (MRI) for detecting spine bone marrow changes in postmenopausal women with osteoporosis (OP). A total of 101 postmenopausal women, mean age of 60.97 ± 7.41 (range 52–68) years old, who underwent dual-energy X-ray absorptiometry of the spine, were invited to this study and divided into three bone density (normal, osteopenic, and osteoporotic) groups based on T-score. After that MRI scan with both FSE T 2 -w and DWI of the vertebral body was done to calculate the signal-to-noise ratio (SNR) and apparent diffusion coefficient (ADC). Finally, MRI findings were compared in patients, between three groups and correlated with bone marrow density. Results The osteoporotic group showed significantly lower mean ADC values, compared to osteopenic and normal groups (0.58 ± 0.02 vs. 0.36 ± 0.05 vs. 0.24 ± 0.06 × 10 –3 mm 2 /s, p < 0.001). According to these results, a significant positive correlation was found between T-scores and ADC values ( r = 0.652, p < 0.001). The mean SNR in FSE T 2 -w images for normal, osteopenic, and osteoporotic groups was calculated 5.61 ± 0.32, 5.48 ± 0.55, and 6.63 ± 0.67, respectively. No significant correlation was found between the mean SNR and T-score for all groups ( r = − 0.304, p > 0.05). Conclusions DWI can be used as a noninvasive, quantitative, and valuable technique for OP evaluation. While, routine MRI needs more investigation to be demonstrated as a reliable diagnostic indicator for OP.
Optimization-free customization of optical tightly focused fields: uniform needles and hotspot chains

Field: Physics and Astronomy (Physical Sciences)

An optimization-free method based on an inverse problem of nonlinear equations is employed to design the binary phase diffraction optical element (BPDOE) that could modulate the incident light of a high-numerical-aperture (NA) objective lens so that the axisymmetric focal fields can be customized on demand. For example, a 43 λ -long optical longitudinally polarized needle with its lateral size beyond diffraction limit is reported by using a 27-belt BPDOE, where the cost evaluated by the ratio of the belt number of BPDOE to the length of needle is record small compared with other optimization algorithms. Moreover, another longitudinal field with multiple hotspots along the propagation direction of light is also achieved with a 10-belt BPDOE. These achieved focal fields are verified doubly by using a finite-difference time-domain (FDTD) method, indicating the validity of Richards–Wolf vector diffraction theory. This optimization-free approach makes the design of BPDOEs with numerous belts viable to generate the expected focal fields, which might benefit various applications such as optical trapping, super-resolution imaging, and lithography.
Conservative Cowboy Stories: Adventures of the Chosen Sons

Field: Arts and Humanities (Social Sciences)

In the January 1995 issue in a front-page article, Dr. Robert Zubrin describes with simple clarity the terrain for conservative reconstructions of the real America, though his particular application of it is a bit extreme. The adventurous cowboys stake a claim to what Michael Rogin calls "the countersubversive position at the center of American politics," its contemporary incarnation beginning with Reagan as exemplary frontier hero, a role aptly suggested by Rogin's title, Ronald Reagan, the Movie. American identity itself was remade through the encounter with successive frontiers, as diverse people remade themselves into Americans, producing sameness out of difference: "The frontier is the line of most rapid and effective Americanization". In the Contract with America, those repressed elements are reactivated and publicly invested as objects of fear, loathing, and legitimate violence or rhetorical condemnation. Although Jacqueline Rose's discussion of radical conservatism focuses on Thatcher, it has much to say about the American version.