jimnoneill/paper-to-field-training huggingface dataset:
Data from Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

<div>Abstract<p><b>Purpose:</b> Accumulating evidence indicates a high degree of plasticity and compensatory signaling within the human epidermal growth factor receptor (HER) family, leading to resistance upon therapeutic intervention with HER family members.</p><p><b>Experimental Design/Results:</b> We have generated Pan-HER, a mixture of six antibodies targeting each of the HER family members EGFR, HER2, and HER3 with synergistic pairs of antibodies, which simultaneously remove all three targets, thereby preventing compensatory tumor promoting mechanisms within the HER family. Pan-HER induces potent growth inhibition in a range of cancer cell lines and xenograft models, including cell lines with acquired resistance to therapeutic antibodies. Pan-HER is also highly efficacious in the presence of HER family ligands, indicating that it is capable of overcoming acquired resistance due to increased ligand production. All three target specificities contribute to the enhanced efficacy, demonstrating a distinct benefit of combined HER family targeting when compared with single-receptor targeting.</p><p><b>Conclusions:</b> Our data show that simultaneous targeting of three receptors provides broader efficacy than targeting a single receptor or any combination of two receptors in the HER family, especially in the presence of HER family ligands. Pan-HER represents a novel strategy to deal with primary and acquired resistance due to tumor heterogeneity and plasticity in terms of HER family dependency and as such may be a viable alternative in the clinic. <i>Clin Cancer Res; 21(18); 4110–22. ©2015 AACR</i>.</p><p><i>See related commentary by Yarden and Sela, p. 4030</i></p></div>
A Rapid and High-Throughput Screening Approach for Methicillin-Resistant Staphylococcus aureus Based on the Combination of Two Different Real-Time PCR Assays

Field: Immunology and Microbiology (Life Sciences)

ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen that has been responsible for major nosocomial epidemics worldwide. For infection control programs, rapid and adequate detection of MRSA is of great importance. We developed a rapid and high-throughput molecular screening approach that consists of an overnight selective broth enrichment, followed by mecA , mecC , and S. aureus -specific (SA442 gene) real-time PCR assays, with subsequent confirmation using a staphylococcal cassette chromosome mec element (SCC mec )- orfX -based real-time PCR assay (GeneOhm MRSA assay) and culture. Here, the results of the screening approach over a 2-year period are presented. During this period, a total of 13,387 samples were analyzed for the presence of MRSA, 2.6% of which were reported as MRSA positive. No MRSA isolates carrying the mecC gene were detected during this study. Based on the results of the real-time PCR assays only, 95.2% of the samples could be reported as negative within 24 h. Furthermore, the performance of these real-time PCR assays was evaluated using a set of 104 assorted MRSA isolates, which demonstrated high sensitivity for both the combination of mecA and mecC with SA442 and the BD GeneOhm MRSA assay (98.1% and 97.1%, respectively). This molecular screening approach proved to be an accurate method for obtaining reliable negative results within 24 h after arrival at the laboratory and contributes to improvement of infection control programs, especially in areas with a low MRSA prevalence.
PALM CLIPPING AND NONLINEAR COMPANDING TECHNIQUES BASED PAPR REDUCTION IN OFDM-DCSK SYSTEM

Field: Computer Science (Physical Sciences)

The main drawback of the Orthogonal Frequency Division Multiplexing (OFDM) with Differential Chaos Shift Keying (DCSK) that is named (OFDM-DCSK) is the high Peak to Average Power Ratio (PAPR). In this paper, clipping and companding techniques are suggested to overcome the PAPR problem in the OFDM-DCSK system. For the clipping technique, the clipping function is applied before transmitting the signal without the need for an inverse function at the receiver side. While for companding techniques, the commanding function is applied at the end of the transmitter side and the corresponding decompanding function is applied at the receiver to recover the original signal. Different companding techniques are investigated including Hyperbolic, A-Law, and Mu-Law companding function that are compared with the Palm clipping technique. The MATLAB simulation result shows that the Mu-Law technique has the best PAPR reduction (7.22 dB) with a good bit error rate (BER) performance when the number of subcarriers is equal to 512.
Perceptions of ASIMO: An exploration on co-operation and competition with humans and humanoid robots

Field: Psychology (Social Sciences)

Recent developments in humanoid robotics have made possible a vision of robots in everyday use in the home and workplace. However, little is known about how we should design social interactions with humanoid robots. We explored how cooperation versus competition in a game shaped people&apos;s perceptions of ASIMO. We found that in the co-operative interaction, people found the robot more sociable and more intellectual than in the competitive interaction while people felt more positive and were more involved in the task in the competitive condition than in the co-operative condition. Our poster presents these findings with the supporting theoretical background. conflict in small groups show that members of co-operative groups approach their group members more positively than members of competitive groups do [2,4]. Moreover, co-operative situations are friendly, intimate, and involving, whereas competitive ones tend to feel unfriendly, nonintimate, and uninvolving [4]. Based on these results, we hypothesized that people who interact with a robot in a co-operative task will perceive the robot more positively and feel more positively than people who interact with the robot in a competitive task. 21
Country-wide case studies: Kenya – A focus on ILO/IPEC and the Time Bound Programme

Field: Social Sciences (Social Sciences)

This chapter is the second of three country-wide case studies examining the impact of national policies to tackle child labour. With regard to Kenya, the chapter examines two programmes introduced by ILO in 1992 and 2004 known as the ILO/IPEC Country Programme and the Time Bound Programme. The focus in Kenya has been principally on raising awareness to change attitudes and practices and policy, on legislative reforms to enhance implementation and enforcement, and on direct support to enable children to attend school and acquire skills.
Data_PONE_D15_54189.zip

Field: Medicine (Health Sciences)

Here is the data for Manuscript on Plos one (ID-PONE-D15-54189). More details are as follows.
This spreadsheet lists the values of the 16 features listed in Table 7 of the paper for all 30 study subjects. The subjects are divided into the control and OSAS groups. This data can be used to test the accuracy of class prediction by using logistic regression as explained in the paper.
An unusual vocalization of Brown Hawk-Owl Ninox scutulata (Raffles, 1822) (Aves: Strigiformes: Strigidae) recorded from Kerala, India

Field: Agricultural and Biological Sciences (Life Sciences)

An unusual vocalisation of Brown Hawk-Owl was recorded from Thrissur. It was distinctive continuous calls of the species heard frequently during 2315 to 2345 h. The bird was photographed; spectrogram was prepared from the call. It is a new addition to the existing recorded vocalisation of the species.­­
Trump and the CIA : borrowing from Nixon's playbook

Field: Social Sciences (Social Sciences)

Former U.S. President Richard Nixon did not mince his words when it came to the Central Intelligence Agency (CIA). He called it “disloyal,” “unproductive,” “over - staffed,” “not worth a damn,” and even asked, “What the hell do those clowns do out there in Langley?” The country’s combative new Commander-in-Chief Donald Trump has had similar words for the agency, branding U.S. intelligence officers as “disgraceful,” “politically motivated,” and “sick people” who spread fake news. Although commentators have been quick to point out key similarities between Trump and Nixon — for example, their ability to nurse a grudge, their obsession with conspiracies, their hatred of the press, their professed “outsider” status, and their willingness to fight or the ignored and forgotten “great silent majority” — few have yet probed the remarkable parallels in their relationship with America’s premier spy agency.
Variable-step preconditioned conjugate gradient method for partial symmetric eigenvalue problems

Field: Mathematics (Physical Sciences)

The iterative methods for partial algebraic symmetric eigenvalue problems are considered for sparse positive definite matrices which arise in approximation of 2D and 3D boundary value problems. The approach is based on subspace iterations, Rayleigh–Ritz method, and the variable-step preconditioned conjugate gradient algorithm, including algebraic multigrid and incomplete factorization. Theorems on the properties of convergence rate are presented. The efficiency of the proposed iterative processes is demonstrated by the results of numerical experiments.
BIPOLAR CONTROL IN AGONISTIC ANTAGONISTIC NETWORKS AND PARTICULARLY IN IMBALANCED STRANGE ATTRACTORS

Field: Mathematics (Physical Sciences)

In some previous papers, we have already demonstrated how the problem of strange attractors (SA) was not confined only to the nature of their dynamics and how the aim of control did not depend only on the fact, that such a dynamics was considered as favourable or wrong for the functioning of the system modelled by these SA. The topology in the phase space of a SA is of the same importance because ergodic theory allows us to take into account the mean values of the various trajectories in this SA. As far as biomathematical models are concerned, these mean values may correspond either to physiological values or to pathological ones. In this regard rather than trying to eliminate (or re-establish) a chaotic dynamics (CD), control should sometimes try to displace the SA in order to let the mean values return to some physiological value. This paper reports a theoretical study of such a type of SA-control by using a so-called "model for the regulation of agonistic antagonistic (AA) couples" or "AA networks", including equations governing the values of certain control variables and has initially been connected to periodic dynamics; we recall these principles of control in case of an elementary AA-model (imbalanced limit-cycles). In case of AA-networks showing a CD, it is also possible to re-establish the balance between the variables with or without eliminating the CD of the attractor; in the second case, the control variables disclose a CD by themselves.
Anti-A1 Specific Lectin from a Central American Leguminous Plant

Field: Agricultural and Biological Sciences (Life Sciences)

Summary An anti-A1 specific lectin has been found in an extract of Crotalaria breviflora, a leguminous plant from Costa Rica. α-Lactose and l-rhamnose did not neutralize the agglutination reaction for human blood group A1 when tested against extracts of C. breviflora and Crotalaria selectron, but inhibited the reactions with groups A2, B, and O cells. A comparison of the variability of reactivity of different species of Crotalaria to subgroups of human type A is reported.
Body shape concerns in bulimia nervosa

Field: Psychology (Social Sciences)

Overconcern with shape and weight is considered a primary feature of the psychopathology of bulimia nervosa and was included as a diagnostic criterion in DSM- III-R. In order to test the significance of shape and weight concern in bulimia nervosa, we administered the Body Shape Questionnaire (BSQ) to 78 outpatients with bulimia nervosa and three comparison groups: 14 women with seasonal affective disorder (SAD), 10 acquaintances of patients, and 32 normal controls. Women with bulimia nervosa had significantly higher mean BSQ scores than did other subject groups. Other self-report measures of body shape concern, eating attitudes, and depression were correlated with BSQ score. Furthermore, all patients had BSQ scores greater than the average score of the normal control group. These data support the continued inclusion of body shape and weight overconcern as a diagnostic criterion for bulimia nervosa but suggest that "overconcern" should be interpreted as "above average" rather than "outside the normal range".
Empirical Bayes Procedure for Selecting the Best Exponential Population

Field: Mathematics (Physical Sciences)

Assume that there are k ( 2≥k) populations kππ,,1 L such that the distribution of iπ is an exponential distribution with parameter iθ, ki,,1L =. Let 0θ and 0δ be two given controls. We would like to identify the best population whose parameter is mostly closed to 0θ from the qualified subset which is a set that includes populations whose relevant parameter lies between 0θ and 0θ + 0δ. It is clear that this article will involve a parameter and three criteria when exploring the problem of selection. This research is based on the framework of Bayes, using empirical Bayes approach to solve the selection problem. Our main consideration here is to select the so-called best population among the k populations with exponential distribution. The relevant empirical Bayes decision rule has been presented and proven to be asymptotically optimal.
Oblivious transfers and intersecting codes

Field: Computer Science (Physical Sciences)

Assume A owns t secret k-bit strings. She is willing to disclose one of them to B, at his choosing, provided he does not learn anything about the other strings. Conversely, B does not want A to learn which secret he chose to learn. A protocol for the above task is said to implement one-out-of-t string oblivious transfer, denoted (/sup t//sub 1/)-OT/sup k//sub 2/. This primitive is particularly useful in a variety of cryptographic settings. An apparently simpler task corresponds to the case k=1 and t=2 of two 1-bit secrets: this is known as one-out-of-two bit oblivious transfer, denoted (/sup 2//sub 1/)-OT/sub 2/. We address the question of implementing (/sup t//sub 1/)-OT/sup k//sub 2/ assuming the existence of a (/sup 2//sub 1/)-OT/sub 2/. In particular, we prove that unconditionally secure (/sup 2//sub 1/)-OT/sup k//sub 2/ can be implemented from /spl Theta/(k) calls to (/sup 2//sub 1/)-OT/sub 2/. This is optimal up to a small multiplicative constant. Our solution is based on the notion of self-intersecting codes. Of independent interest, we give several efficient new constructions for such codes. Another contribution of this paper is a set of information-theoretic definitions for correctness and privacy of unconditionally secure oblivious transfer.
[The DNA binding activity of nuclear factor-ΚB in patients with severe pneumonia and the intervention effects of Xuebijing injection].

Field: Medicine (Health Sciences)

NF-ΚB activation and coagulopathy were observed in patients with severe pneumonia, and NF-ΚB was involved in the process of inflammatory response. Inflammatory response was partly alleviated by Xuebijing injection. These effects of Xuebijing injection may be mediated by inhibition of the activation of NF-ΚB and its anticoagulation property.
Toxicity of Aqueous L-Selenomethionine and Tert-Butyl Hydroperoxide Exposure to Zebrafish (Danio rerio) Embryos Following Tert-Butyl Hydroquinone Treatment

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Aqueous L-selenomethionine (SeMet) embryo exposures represent a rapid and simplified method for investigating the embryotoxic effects of SeMet. Using zebrafish (Danio rerio) as a model organism, the objective of the present study was to characterize the effects of waterborne exposure to both SeMet and tert-butyl hydroperoxide (tBOOH) to early life stages of zebrafish pre-treated with the antioxidant tert-butyl hydroquinone (tBHQ) in an attempt to investigate the mechanism of Se toxicity as it relates to oxidative stress. During the initial concentration range finding experiment, recently fertilized embryos were exposed for five days to 5, 25, 125, and 625 µg Se/L (as SeMet). These exposures informed the second experiment in which embryos were exposed to two concentrations of SeMet (25 and 125 µg Se/L) and 75 mg/L tBOOH either with (tBOOH-t, 25-t, 125-t) or without (tBOOH, 25, 125) a 4 h 100 µg/L tBHQ pre-treatment. Survival, hatchability, time to hatch, the frequency and severity of deformities (total and type), and changes in the expression of seven antioxidant-associated genes were determined. Exposures to SeMet and tBOOH reduced hatchability, increased time to hatch, decreased survival, increased the incidence and severity of deformities, and increased glutathione-disulfide reductase (gsr) expression in the pre-treated tBOOH treatment group.
Activity of Daptomycin against Listeria monocytogenes Isolates from Cerebrospinal Fluid

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

ABSTRACT We tested the activity of daptomycin against 76 Listeria monocytogenes isolates from cerebrospinal fluid by broth dilution and Etest methods. For the broth dilution method, the MIC range was 1.0 to 8.0 and the MIC at which 90% of the isolates tested were inhibited (MIC 90 ) was 4.0 mg/liter. For the Etest method, the MIC range was 1.0 to 4.0 and the MIC 90 was 4.0 mg/liter. Presently, daptomycin cannot be recommended for the treatment of L. monocytogenes meningitis.
The use of citation and reference resources in the writing of postgraduate theses and its relationship with textual plagiarism

Field: Arts and Humanities (Social Sciences)

The increase in cases of plagiarism in the academic and scientific world and the need for universities to guarantee the quality and originality of their graduat's theses force us to pay attention to the processes of teaching academic-scientific writing. Based on the linguistic discourse analysis, we describe the knowledgeattribution resources used by masters’ degree students in the humanities when writing their theses. Our exploratory study seeks to show the strategies that students use to generate their own texts using disciplinary knowledge taken from other sources. The results show that thesis writers have trouble identifyingthe different functions that citations and references fulfill in the construction of academic and scientificdialogue, which places them at great risk of committing plagiarism. These findings lead us to reflect on the issue of academic writing in the university, and the need to propose intervention plans that address plagiarism as a phenomenon related to the use of language and allow students in these programs to generate their own texts.
Understanding Learner Behaviour in Online Courses through Learning Analytics

Field: Social Sciences (Social Sciences)

Building an effective online course requires an understanding of learning analytics. The study assumes significance in the COVID 19 pandemic situation as there is a sudden surge in online courses. Analysis of the online course using the data generated from the Moodle Learning Management System (LMS), Google Forms and Google Analytics was carried out to understand the tenants of an effective online course. About 515 learners participated in the initial pre-training needs & expectations’ survey and 472 learners gave feedback at the end, apart from the real-time data generated from LMS and Google Analytics during the course period. This case study analysed online learning behaviour and the supporting learning environment and suggest critical factors to be at the centre stage in the design and development of online courses; leads to the improved online learning experience and thus the quality of education. User needs, quality of resources and effectiveness of online courses are equally important in taking further online courses.
Robust Multicriteria Sustainability Assessment in Urban Transportation

Field: Decision Sciences (Social Sciences)

Developing methodologies to facilitate the planning of sustainable transport systems for decision makers (DMs) is becoming more critical. This study proposed a methodological framework for sustainable urban transportation to make decisions during urban transportation's design and planning stages. Urban transportation alternatives were evaluated by sustainability indicators that considered a triple bottom line approach's environmental, economic, and social aspects. To choose the best alternative sustainable transportation scenarios, two multicriteria decision-making (MCDM) methods, for example, a hesitant fuzzy analytical hierarchy process (HF–AHP) and multiple attribute utility model (MAUT), were integrated. First, eight sustainable transportation indicators that considered data availability from the transport sector were selected. The weights of the selected indicators were calculated using an HF–AHP. These indicators included carbon dioxide (CO2) emissions, energy consumption, depletion of nonrenewable resources, operational and maintenance costs, fuel and taxes, the number of fatalities or injuries, and motor vehicles for public transport per 10,000 population. Finally, sensitivity analysis was applied to validate the robustness. Based on HF–AHP results, the number of fatalities or injuries was the most significant among the eight indicators, with a 0.158 normalized weight (Ni). The results of this integrated methodology highlighted that Alternative 11, which was dominated by low-motorized vehicles (low-MVs), was the best sustainable alternative and Alternative 1 was the worst sustainable alternative, which was dominated by high-MVs with 0.69 and 0.27 total utility values, respectively. Low-motorized urban transportation alternatives showed higher sustainable performances than the motorized and high-motorized alternatives. This study proposed a novel and robust methodology for decisions on sustainable urban transportation projects and renovating current urban transportation systems.
Selective N-methylations of heterocycles with dimethyloxosulfonium methylide

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective N-methylations of heterocycles with dimethyloxosulfonium methylideTakehisa Kunieda and Bernhard WitkopCite this: J. Org. Chem. 1970, 35, 11, 3981–3982Publication Date (Print):November 1, 1970Publication History Published online1 May 2002Published inissue 1 November 1970https://pubs.acs.org/doi/10.1021/jo00836a096https://doi.org/10.1021/jo00836a096research-articleACS PublicationsRequest reuse permissionsArticle Views135Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts