jimnoneill/paper-to-field-training huggingface dataset:
Melanoma, gene and hormonal therapy

Field: Medicine (Health Sciences)

Problem u lijecenju melanoma je da zbog rezistentnosti melanoma na postojece citostatike i imunoloske agense ne postoji standardno sistemno lijecenje kod metastatske bolesti, niti kemoterapijsko niti imunoterapijsko. U bolesnika pocetnih stadija bolesti izljecenje se može postici i odgovarajucim kirurskim zahvatom dok je metatski melanom najcesce neizljeciva bolest. Nadalje, i kod metastatske bolesti klinicki tijek bolesti može biti razmjerno nepredvidiv. Stovise, u pojedinih bolesnika s metastatskom bolescu uspije se katkada lijecenjem postici dugotrajna remisija pa možda i izljecenje. Melanom se inace smatra tumorom u kojega imunoterapija ima potencijalnu ulogu. U tu svrhu upotrebljavaju se razni agensi, od npr. tvari koje mogu modulirati imunolosku reaktivnost bolesnika (BCG, interferon- , interleukin-2) pa do vakcina raznog sastava. Rekombinantni interferon- (rIFN- ) se cesto upotrebljava u adjuvantnoj primjeni u bolesnika stadija bolesti IIB i III. Primjenjen po tzv. “ visokodoznoj” shemi postiže se, a u usporedbi s kontrolnom nelijecenom skupinom bolesnika, statisticki znacajna razlika u preživljenju bez relapsa bolesti. U svezi sveukupnog preživljenja reanalize podataka nakon produženog pracenja bolesnika upucuju da se vise nema statisticki znacajne razlike. Od brojnih vakcina, a također u adjuvantnoj primjeni, možda se klinicki povoljan ucinak može ocekivati s vakcinom “ Canvaxin” . Ona je sada u klinickom testiranju faze III. U pojedinih bolesnika s metastatskom bolescu dugotrajna remisija se uspije katkada postici s visokodoznim rekombinatnim interleukinom-2 (rIL-2). U metastatskoj bolesti postoji i mogucnost primjene kemoterapije i citokina rIL-2 i rIFN- (biokemoterapija). Postoje također brojne klinicke studije faze I i II s testiranjem raznih vakcina kao i studija uporabe autolognih antimelanomskih T-limfocita prethodno umnoženih in vitro u bolesnika podvrgnutih nemijeloablativnom kondicioniranju.
DPRNN-Former: An Efficient Way to Deal with Blind Source Separation

Field: Computer Science (Physical Sciences)

Recent advancements in DL have indicated that time-domain methods are more successful than traditional time-frequency-based methods regarding speech separation. However, modeling very long sequences in time-domain separation systems presents some challenges. Recurrent neural networks and 1-D convolutional neural networks are not sufficient for modeling lengthy sequences by themselves. In this paper, a hybrid RNN is proposed, combining a pre-trained DPRNN and transformer. This strategy uses the transformer's ability to perceive context, allowing it to gain insight into the time-evolving data connected to audio signals. To handle extended input sequences, the network partitions them into more manageable sections, performing intra-section and inter-section operations iteratively. The proposed network surpasses current state-of-the-art algorithms, achieving SI-SNR of 11.129 and SDR of 11.285 dB on the public WSj0-3mix dataset.
An overlooked name provides the basionym for a new combination in Malagasy Tarenna (Rubiaceae)

Field: Agricultural and Biological Sciences (Life Sciences)

Turner, I.M. (2022). Un nom oublié fournit le basionyme d'une nouvelle combinaison de Tarenna (Rubiaceae) à Madagascar. Candollea 77: 237–240. En anglais, résumés anglais et français. Pavetta madagascariensis Ten. (Rubiaceae) est un nom oublié décrit à partir de matériel cultivé dans le jardin botanique de Naples. Le nom est ici transféré à Tarenna Gaertn. sous le nom de T. madagascariensis (Ten.) I.M. Turner, et il devient le nom correct pour l'espèce actuellement désignée sous le nom de T. grevei (Drake) Homolle. Des néotypes pour Pavetta madagascariensis et P. gracilis A. Rich. ex DC. sont désignés respectivement et un lectotype pour Ixora grevei Drake.
Urinary Excretion of DDA Following Ingestion of DDT and DDT Metabolites in Man

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Oral doses of DDT (5, 10, 20 mg/day) DDE, DDD, and DDA (5 mg/day) administered to human volunteers are, in part, excreted as DDA in the following order: DDA>DDD>DDT. Ingestion of DDE failed to produce any increase of DDA excretion. Increased urinary DDA excretion is detectible within 24 hours of DDT, DDD, or DDA ingestion. DDA excretion returns to predose levels within two to three days of dose termination for DDA but continues significantly above predose levels for over four months following termination of DDD or DDT doses.
Assessment of complications after transperineal and transrectal prostate biopsy using a risk-stratified pathway identifying patients at risk for post-biopsy infections

Field: Medicine (Health Sciences)

Our study revealed that even in a well-selected patient cohort with presumably lower risk of infectious complications, TR biopsy leads to more post-biopsy complications than TP biopsy. This conclusion should motivate the urological community to switch to TP biopsy.
Measurement of Splenic Function in Humans using Heat Damaged Autologous Red Blood Cells

Field: Medicine (Health Sciences)

Functional hyposplenism, a clinical entity which has only recently been recognised, is usually assessed quantitatively by the rate of clearance of radiolabelled heat damaged erythrocytes (HDE) from the circulation. Based on recent observations on the kinetics of HDE, we have developed a 3 compartmental model of HDE distribution between the spleen and blood, and calculated, in a large series of clearance curves, splenic blood flow, HDE intrasplenic transit time and splenic HDE extraction ratio. Transit time (about 15 min) was of the same order as platelet transit time and extraction ratio (about 35%) was similar to that recorded in animals. The relationships between blood flow, transit time and extraction ratio provided evidence in support of 2 separate functional compartments, of which only one was engaged in phagocytosis, present within the spleen.
Relation between Order of Completion and Performance on Timed Examinations

Field: Psychology (Social Sciences)

The relation between order of completion and test performance was examined. Subjects were 116 students in two upper-division psychology courses. Tests were timed and contained both objective and nonobjective items. Contrary to previous suggestions but consistent with prior empirical findings, there was neither a consistent linear nor curvilinear relation between order of completion and performance. In one class, middle finishers tended to score lower and to be more variable in performance than early and late finishers. Results are discussed in the context of previous research on the relation between time (or order) of completion and test performance.
Database research at the University of Illinois at Urbana-Champaign

Field: Computer Science (Physical Sciences)

article Share on Database research at the University of Illinois at Urbana-Champaign Authors: M. Winslett Urbana, IL Urbana, ILView Profile , K. Chang Urbana, IL Urbana, ILView Profile , A. Doan Urbana, IL Urbana, ILView Profile , J. Han Urbana, IL Urbana, ILView Profile , C. Zhai Urbana, IL Urbana, ILView Profile , Y. Zhou Urbana, IL Urbana, ILView Profile Authors Info & Claims ACM SIGMOD RecordVolume 31Issue 3September 2002 pp 97–102https://doi.org/10.1145/601858.601881Published:01 September 2002Publication History 0citation378DownloadsMetricsTotal Citations0Total Downloads378Last 12 Months2Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Prognostic factors of survival after radiotherapy for metastases to the spinal column and a scoring system of survival: Review of 530 patients in Shizuoka Cancer Center Hospital

Field: Medicine (Health Sciences)

9608 Background: The role of radiotherapy (RT) for patients with spine metastases has been well established. Several reports indicated to select optimal RT schedule appropriate for survival was important; standard-course RT for good predicted survival and short-course RT for poor predicted survival. In this report, we retrospectively analyzed prognostic factors of survival and make a scoring system to predict survival of the patients with spine metastases. Methods: Five hundred and thirty patients with spine metastases were irradiated at Shizuoka Cancer Center Hospital between September 2002 and December 2006. The prognostic factors for survival were studied using the Cox proportional hazards model. Based on the regression coefficient of the multivariate analyses, a scoring system was developed. The scoring system is as follows; 3 points were allocated for unfavorable tumor type, and bad performance status (3 or more), 2 points were allocated for hypercalcemia, visceral metastases, and previous chemotherapy and 1 point was allocated for multiple bone metastases, and elderly (65 years or older). Results: The overall survival rates for all cases after 6, 12 and 24 months were 49.1% (95% confidence intervals [CI]: 45% to 53%), 32.5% (95% CI: 28% to 37%), and 18.9% (95% CI: 15% to 23%), respectively. Median overall survival periods were 5.9 months (95% CI: 4.9 to 6.8 months). Of the 530 patients, 489 patients (92.3%) were followed for a minimum of 12 months, unless death supervened, during which time 41 patients were lost to follow-up. The survival curves can be separated into three groups: Group A, with total scores of 0–5; Group B, with total scores of 6–9; Group C, with total scores of 10–14. 32% of patients were in Group A (MST = 21.3 months), 48% were in Group B (MST = 5.1 months), and 20% were in Group C (MST = 1.8 months). The overall survival rates after 6, 12 and 24 months were: 82%, 65% and 45% in Group A; 43%, 21% and 7% in Group B; 6%, 4% and 0% in Group C, respectively (p<0.001). Conclusions: This scoring system would predict survival of the patients with spine metastases. Further prospective investigation is needed to select optimal RT schedule appropriate for survival using this scoring system. No significant financial relationships to disclose.
Isolation of moniliphenone, a key intermediate in xanthone biosynthesis from Monilinia fructicola.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Twonew metabolites were isolated from a culture filtrate of Monilinia fructicola during a biosynthetic study of chloromonilicin (la),1} a novel growth self-inhibitor produced by this fungus.Bromomonilicin (lb) and its precursor 4-bromopinselin (2b), a fungal xanthone, have already been isolated from the fermentation broth obtained by inoculation into a KBrcontaining medium.2)The new metabolites were basically a xanthone derivative and a benzophenone derivative, respectively, and
Faculty Opinions recommendation of Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Mounting evidence indicates that Merkel cell polyomavirus (MCV), a circular double-stranded DNA virus, is a causal factor underlying a highly lethal form of skin cancer known as Merkel cell carcinoma. To explore the possibility that MCV and other polyomaviruses commonly inhabit healthy human skin, we developed an improved rolling circle amplification (RCA) technique to isolate circular DNA viral genomes from human skin swabs. Complete MCV genomes were recovered from 40% of healthy adult volunteers tested, providing full-length, apparently wild-type cloned MCV genomes. RCA analysis also identified two previously unknown polyomavirus species that we name human polyomavirus-6 (HPyV6) and HPyV7. Biochemical experiments show that polyomavirus DNA is shed from the skin in the form of assembled virions. A pilot serological study indicates that infection or coinfection with these three skin-tropic polyomaviruses is very common. Thus, at least three polyomavirus species are constituents of the human skin microbiome.Copyright (c) 2010 Elsevier Inc. All rights reserved. PMID: 20542254 Funding information This work was supported by: Intramural NIH HHS, United States Grant ID: ZIA BC011090-02
702 Acute Burn Treatment and Mechanical Ventilation

Field: Medicine (Health Sciences)

Abstract Introduction Our aim was to explore MV during the acute burn treatment and factors associated with successful extubation. Methods A retrospective review was performed on all burn patients that required MV in a reference burn center from December 2015 to April 2018. Patients successfully extubated or on trach collar (Group1) were compared to those that required re-intubation or died on MV (group2). The patients were also grouped depending on duration of MV, after excluding the patients that died under MV: Group A, 3 or less days; Group B, 4 or more days. A p 0.05 was considered significant. Results Out of a total of 104 burn patients on MV, 7 patients arrived intubated after coding on the field, were confirmed dead on the first 24 hours, and were excluded from the analysis. The mean expected mortality rate was 21.5±31%, 19 (19.5%) died during the admission. The patients remained intubated for 13±19 days, tracheostomy was performed in 20 (21%), after 26±15 days. Fifty-five (56.7%) of the patients were smokers or former smokers, 34 (35%) were illicit drug users, 16 (16.5%) had alcohol intoxication when burned. Inhalation injury was suspected in 80 (82.5%) of the patients, and confirmed in 41 (42.3%). Group 1 was younger: 48.42±18.66 vs 59.15 ± 21.38, p=0.032. Although a smaller rate of confirmed inhalation injury was seen among group1, it was not statistically significant (Group1: 25 (36.8%); group2: 16 (55.2%) (P=0.09). The TBSA burned was bigger on group 2: 18.4%±19.72 vs 34.39%±25.86, p=0.002. History of drug use was not associated with extubation success: group1: 26 (38%); group2: 8 (27.6%); (P=0.314). The expected mortality was significantly higher among group2: 10%±16.1% vs 48.54%±39.33%, p&lt; 0.001. Group1 was associated with the use of less albumin and crystalloids on the first 24h and a bigger volume of urine on Day1 (Table1). A sub-analysis of the group that required re-intubation (n=10) and the successfully extubated showed an increased rate of psychiatric illness among the group requiring re-intubation: 18 (26.5%) vs 7 (70%), p&lt; 0.001. The group that required a shorter time on the MV (GroupA) had a shorter length of stay, smaller percentage of TBSA, required fewer surgeries, and received less albumin and crystalloids on Day1 (Table2). Conclusions Lower expected mortality and age, and smaller %TBSA burned are associated with a successful extubation. Psychiatric illness may be associated with the need for re-intubation. Applicability of Research to Practice This study highlights the association of psychiatric illness and difficulty extubating the burn patient.
DESCRIPTION OF SODIUM LEVELS BASED ON SEVERITY OF DISEASE IN PEDIATRIC MENINGITIS PATIENTS

Field: Medicine (Health Sciences)

BACKGROUND Children are more susceptible to infection. Meningitis is an inflammatory reaction of the meninges which is characterized by an increased leukocytes in the cerebrospinal fluid. The incidence of childhood meningitis is still high and mostly caused by bacteria with high case mortality and neurological sequelae. In tuberculosis (TB) endemic countries, the most common cause of meningitis is tuberculosis. The central nervous system plays a role in sodium and water regulation so in meningitis there are disruption of sodium homeostasis with the most is hyponatremia which associated with systemic complications, disease severity and death. METHODS The study was descriptive, retrospective from medical records of inpatients diagnosed with meningitis (ICD-10), children aged < 18 years and serum sodium results for the period 2019. Patients with a history of renal impairment and forced discharge were excluded. RESULTS TB meningitis is the most common cause of meningitis in children. 68.8% of meningitis patients have hyponatremia with the most is mild hyponatremia (36%). In TB meningitis, the severity of the disease is not directly related to the degree of sodium disorder, while in non-TB meningitis it is related to the severity of the disease. DISCUSSION Hyponatremia is associated with severity in non-TB meningitis. In normonatremia, sodium evaluation is still performed because hyponatremia can occur during treatment. CONCLUSIONS AND RECOMMENDATIONS Meningitis is associated with hyponatremia and is associated with disease severity in non-TB meningitis. Sodium evaluation is necessary in tuberculous meningitis because hyponatremia can occur during the treatment.
Pengaruh Kompetensi Aparat Pengelola Dana Desa, Komitmen Organisasi Pemerintah Desa, dan Partisipasi Masyarakat Terhadap Akuntabilitas Pengelolaan Dana Desa

Field: Social Sciences (Social Sciences)

This study aims to determine the effect of village fund management apparatus competence, village government organizational commitment, and community participation on the accountabilityiofvillageifund management in Tabanan District, TabananiRegency. Theisample used in this study were 12 villages in Tabanan District with 96 respondents. The method of determiningithe sampleiusing purposiveisampling, data were collected using a questionnaire. Data were analyzed using Multiple Linear Regression Analysis. Based on the results of this study, it shows that the competence of village fund management officers and the commitment of village government organizations have no significant effect on the accountability of village fund management, while community participation has a positive and significant effect on the accountability of village fund management in Tabanan District, Tabanan Regency.
DHCP/IPSec-based Security for Wireless Access Networks

Field: Computer Science (Physical Sciences)

Abstract–In this paper we present a simple solution to provide secure access to users/terminals asking for Internet connectivity through a wireless access network. The proposed solution is based on some standard protocols (DHCP, Radius, EAP, and IPSec) and enables user authentication, network configuration parameters personalization, and secure communications on the wireless links. The main strength of our approach is that it can be easily implemented in a wireless local site (WLAN or WPAN) independent of any layer two mechanism and of the manufac-turer’s implemented features in the wireless user terminal. Index Terms — DHCP, IPSec, EAP, Radius
Reduced-Order Modeling for Nonlinear Aeroelasticity with Varying Mach Numbers

Field: Engineering (Physical Sciences)

This paper proposes a nonlinear aerodynamic reduced-order model robust to different Mach numbers based on a recursive neural network. To model the nonlinear features with varying flow parameters, the Mach number is adopted as an additional input variable. The training case is a weighted filtered Gaussian white noise with wide ranges of frequency and amplitude. For a better generalization capability, proper orthogonal decomposition and partial particle swarm optimization algorithm are introduced to the training process. The approach is tested by predicting the unsteady aerodynamic forces and nonlinear aeroelastic behaviors of a NACA 64A010 airfoil in transonic flow across multiple flow conditions. Comparisons of harmonic aerodynamic responses in the time domain and the frequency domain demonstrate that the model accurately captures the main flow characteristics in a range of transonic flows. After coupling the structural equations of motion and the nonlinear reduced-order model, the proposed method precisely predicts the limit-cycle oscillation trends changing with Mach numbers or structural parameters. The computational time of the present approach is only about 4% of the total time cost of full-order simulations based on a computational fluid dynamics solver. Moreover, as the Mach number range is extended, the resulting model can still account for the parameter-varying linear dynamics, providing a good flutter behavior approximation.
Water Distribution System Modeling and Remote Monitoring

Field: Engineering (Physical Sciences)

Abstract Internal corrosion of water distribution piping is often difficult to detect, diagnose, and mitigate, especially if the problems are localized. Corrosion can cause leaks, premature piping failures, and poor water quality in water distribution systems. New commercially available in-situ sensors can detect active corrosion and/or corrosive water and can notify facilities engineers that there is a problem. A new field demonstration of these sensors will be described in this paper. Computer-based simulations of water distribution systems can also be used as a diagnostic tool to help solve corrosion problems. Simulations can help pinpoint areas in which localized hydraulic and/or water quality conditions are contributing to internal piping corrosion. An example will be presented in which an off-line dynamic simulation was used to help locate and diagnose a series of localized corrosion problems in an actual water distribution system. Finally, the above sensors and simulations can be interfaced together with Supervisory Control and Data Acquisition (SCADA) systems to provide a highly accurate, near-real-time description of water system operation. Such a system can be used to automatically control the dosing of water treatment chemicals so that corrosion is mitigated.
Particle deposition from a turbulent flow. I. A steady-state model for high inertia particles

Field: Physics and Astronomy (Physical Sciences)

The steady-state transport and deposition of ‘‘high inertia’’ particles in turbulent duct flow is studied. A relatively simple yet fundamental PDF (probability density function) equation (kinetic equation) is proposed as a model for such systems together with models describing perfectly and partially adsorbing boundaries. Using the idea of particle mean free path it is shown how this equation may be reduced to a universal form. A numerical method of solution based on spectral collocation is presented, and the effectiveness of this is shown to be the result of the substantial reduction in complexity that it affords. Results from this approach are shown to be in very good agreement with those obtained from a random walk simulation, in contrast to those obtained from simple gradient-diffusion and gradient-diffusion/free-flight models. Evaluation of the separate terms in the momentum and energy equations derived from the kinetic equation illustrates how gradient diffusion breaks down close to the depositing wall. Finally, results of particle deposition as predicted by the kinetic equation are compared with those from experiment. Again there is extremely good agreement, despite the relatively simple form of the basic model.
Direct evidence for oscillatory screening in the quantum Hall effect regime

Field: Physics and Astronomy (Physical Sciences)

Oscillations of magneto-donor binding energies are observed in photoluminescence spectra of modulation-doped GaAs/Ga0.67Al0.33As heterostructure. Both the experiment and the underlying theory provide direct evidence for an oscillatory screening of the Coulomb interaction by two-dimensional electron gas in the quantum Hall effect regime.