jimnoneill/paper-to-field-training huggingface dataset:
Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience

Field: Neuroscience (Life Sciences)

Klotho (KL) is a glycosyl hydrolase and aging-suppressor gene. Stress is a risk factor for depression and anxiety that are highly comorbid with each other. The aim of this study was to determine KL is regulated by estrogen and plays an important role in sex differences in stress resilience. Our results showed that KL was regulated by estrogen in rat hippocampal neurons in vivo and in vitro and was essential for estrogen-mediated increase in the number of presynaptic vesicular glutamate transporter 1 (Vglut1) positive clusters on the dendrites of hippocampal neurons. The role of KL in sex differences in stress responses was examined in rats using three-week chronic unpredictable mild stress (CUMS). CUMS produced a deficit in spatial learning and memory, anhedonic-like and anxiety-like behaviors in male but not female rats, which was accompanied by a reduction in KL protein levels in the hippocampus of male, but not female rats. This demonstrated the resilience of female rats to CUMS. Interestingly, knockdown of KL protein levels in the rat hippocampus of both sexes caused a decrease in stress resilience in both sexes, especially in female rats. These results suggest that regulation of KL by estrogen plays an important role in estrogen-mediated synapse formation, and KL plays a critical role in the sex differences in cognitive deficit, anhedonic-like and anxiety-like behaviors induced by chronic stress in rats, highlighting an important role of KL in sex differences in stress resilience.
C C I B A*: An Improved BA* Based Collaborative Coverage Path Planning Method for Multiple Unmanned Surface Mapping Vehicles

Field: Computer Science (Physical Sciences)

The main emphasis of this work is placed on the problem of collaborative coverage path planning for unmanned surface mapping vehicles (USMVs). As a result, the collaborative coverage improved $BA^{*}$ algorithm ( $C C I B A^{*}$ ) is proposed. In the algorithm, coverage path planning for a single vehicle is achieved by task decomposition and level map updating. Then a multiple USMV collaborative behavior strategy is designed, which is composed of area division, recall and transfer, area exchange and recognizing obstacles. Moverover, multiple USMV collaborative coverage path planning can be achieved. Consequently, a high-efficiency and high-quality coverage path for USMVs can be implemented. Water area simulation results indicate that our $CCIBA^{*}$ brings about a substantial increase in the performances of path length, number of turning, number of units and coverage rate.
Medial Hamstring Snapping Knee Syndrome: Case Report of an Unusual Presentation Due to Osteochondroma

Field: Medicine (Health Sciences)

Medial hamstring snapping knee syndrome is an infrequent clinical entity, with osteochondroma being an exceptionally rare etiology. This report details a case of a 21-year-old female presenting with a 4-month history of persistent left knee pain, snapping, and clicking, which developed following a fall. Despite initial conservative management, the symptoms persisted. Advanced imaging, including MRI, revealed a small osteochondroma on the medial aspect of the proximal tibia, which was the underlying cause of the snapping. A targeted physiotherapy regimen emphasizing quadriceps and hamstring strengthening was subsequently employed, leading to effective symptom management. This case highlights the necessity of a meticulous clinical evaluation and the role of advanced imaging in diagnosing rare etiologies of snapping knee syndrome. Furthermore, it demonstrates the efficacy of focused physiotherapy in managing such conditions.
Korelasi Nilai CBR Dengan kepadatan Lapangan Subbase Course

Field: Engineering (Physical Sciences)

The durability of the road flexural pavement structure is largelydetermined by the performance of each layer. One of these factors isthe strength and resilience of the subbase. Compaction inaccordance with applicable standards will produce roads with goodquality so that the road life is longer and there is less damage. Thepurpose of this study is to analyze the carrying capacity using CBR,the value of the field density with the sand cone test and thecorrelation of the CBR value and the Sand cone value of the B gradefoundation layer on the Tugu Munajah network. The researchmethod used is laboratory and field testing combined with adescriptive statistic approach.The results of the study indicate that the carrying capacity using theCBR amounted to 55.02% <60%, the density value field with sandcone test of 72.50% <90%. Correlation of CBR and Sand cone value atthe base layer (sub base course) is very strong at 0.998.
Outcomes of Lumbar Disc Herniation Treatment using Medication Method Coupled with Epidural Hydrocortisone Injection

Field: Medicine (Health Sciences)

Background: Evaluation of lumbar disc herniation treatment outcome using medication method coupled with epidural hydrocortisone injection. Methods: Description, clinical experiment with the control group, supervision, and evaluation on 62 patients before treatment, 15 days after surgery and 30 days after treatment, in 7A Military Hospital (Ho Chi Minh City, VietNam) from November 2015 to June 2016. Group I (control) included 31 patients treated with essential medication. Group II (experiments) included 31 patients treated with essential medication plus lumbar epidural injection. Results: At 30 days after treatment 48.4% experiment patients reported no pain (in comparison with 32.3% control ones), 67.7% experiments reported improvement in lumbar flexion (38.7% controls), 64.5% experiments reported great improvement in Lasegue test (38.7%). Flexion, extension, adduction, and rotation were significantly better improved in experiments than in controls. Daily function improvement in experiments (58.1%) was sharply better than controls (19.4%). In general, 80.7% experiments got “very good” treatment outcome, compared with 67.7% controls. Conclusions: The experiment group got significantly better treatment outcomes than the control group.
Purchase Intention Towards Ready-Made and Custom-Made Products in Textile and Apparel Industry

Field: Business, Management and Accounting (Social Sciences)

An unprecedented change of consumer demand in the Malaysian textile and apparel industry has been an economic impact to various corresponding businesses. Accordingly, “the change” is believed to be the cause that turns the Malaysian industry up-side-down as the consumers decrease their spending on the textile goods extensively ever since the days of the implementation of GST (good and service tax) until today. The objective of this study is to determine the factors which are affecting the Malaysian purchase intention between the ready-made and the custom-made products in the local textile and apparel industry. Nonetheless, the proposed study would discuss the possibilities of outcomes with a series of quantitative measurements and procedures. Moreover, 151 questionnaires were collected and accepted based on the non-probability quota sampling method as the fundamental guideline for this preliminary analysis. The results suggested that there is a significant relationship between the variable name Product Safety and Convenience towards Consumer Satisfaction. Together with, there is also a proven relationship between Attitude and Consumer Satisfaction with Purchase Intention towards ready-made and custom-made products in the Malaysian textile and appeal industry.
Security and Privacy Issues in Content-Centric Networking

Field: Computer Science (Physical Sciences)

Content-Centric Networking (CCN) is a networking paradigm alternative to todayâs IP-based Internet Architecture. One fundamental goal of CCN is to include security and privacy as part of its design. CCN adheres to a simple request and response protocol. Consumers issue interests for named content objects. Routers forward these interests toward content producers. Once the desired content is located, it is returned to the consumer along the same path, in reverse, of corresponding interests. CCN routers can unilaterally cache content to reduce end-to-end latency and bandwidth consumption for future duplicate interests. In this dissertation, we study several security and privacy issues introduced by opportunistic caching in CCN. Specifically, we investigate the influence of caching on consumer and producer privacy, content poisoning attacks, and accounting. For each issue, we describe its root causes, discuss potential countermeasures, and present some experimental results. We conclude that, despite its networking benefits, router caching triggers some important security and privacy problems.
A Case of Unilateral Hemangiomatosis of the Skin.

Field: Medicine (Health Sciences)

30歳の男子。10歳時に初めて右足底母趾基部の皮下腫瘤に気づいた。初診時, 計5個の皮下腫瘤が右側に偏在していた。腫瘤は病理組織学的に海綿状血管腫の所見を呈していた。胸部X線, CT, MRI所見から右側胸壁胸膜外に肺実質を圧迫して存在する腫瘤が認められ, 画像診断上, 海綿状血管腫が疑われた。しかし貧血, 便潜血はなく, 内臓諸臓器には腫瘤を認めなかった。自験例は他臓器病変を伴う他の血管腫症とは異なる, 予後良好な血管腫症と考え, 片側性皮膚血管腫症の名称で報告した。
The SSBP3 Co-Regulator Is a Novel Driver of Islet Cell Structure and Function

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract The activities of transcriptional complexes drive the proper development and function of insulin producing beta-cells, ultimately required for the regulation of glucose homeostasis. Our prior work helped to establish that the LIM-homeodomain transcription factor (TF), Islet-1 (Isl1), directly interacts with the Ldb1 co-regulator in developing and adult beta-cells. We further found that a member of the Single Stranded DNA-Binding Protein (SSBP) co-regulator family, SSBP3, interacts with the Isl1:Ldb1 complex in beta-cells and primary islets to impact critical target genes MafA and Glp1R. Members of the SSBP family of co-regulators stabilize TF complexes in various tissues, ranging from brain to skin, by binding directly to Ldb1 and protecting the factors from ubiquitin-mediated turnover. Because of this, we hypothesized that SSBP3 would have similarly critical roles as Isl1 and Ldb1 for beta-cell development and function in vivo. To assess this, we first developed a novel SSBP3 floxed mouse line, where Cre-mediated recombination is predicted to impart loss of the Ldb1-interacting domain, plus an early termination. We bred this mouse into a Pax6-Cre transgenic line to recombine SSBP3 in the developing pancreatic islet, a model termed SSBP3islet. We found that SSBP3islet neonates become progressively hyperglycemic and both male and female mice are glucose intolerant as early as postnatal day (P) 21. These results are similar to previous Ldb1 and Isl1 knockouts in the embryonic islet, both of which were hyperglycemic by P10. We observed a reduction of the beta-cell maturity marker, MafA, and disruptions in islet cell architecture with an apparent increase in both glucagon+ alpha-cells and ghrelin+epsilon-cells at P10 and P28. In ongoing studies we are generating embryonic day (E)18.5 embryos to determine islet development defects and will conduct chromatin immunoprecipitation (ChIP) experiments to determine the beta-cell and islet genes directly bound by SSBP3 in vivo. These experiments will further elucidate the regulation of islet function by LIM complexes, knowledge that is central not only for our understanding of glucose homeostasis but for the development of novel diabetes therapeutics.
A study on the implementation approaches of University Incubation Centres to reinforce entrepreneurship - taking the example of Singapore

Field: Business, Management and Accounting (Social Sciences)

Abstract Purpose This study deals with missions, significant policies, operational approaches, and training programs learned from Singapore's experiences, thus contributing to a more profound knowledge of entrepreneurship in order to establish suggestions and boost the implementation of entrepreneurship and incubator business, particularly in universities in Indonesia. This study purposes to understand in-depth the practical implementation approaches of university incubation centres to facilitate entrepreneurship in Singapore. Insights were obtaining following a literature review approach. Design/methodology/approach Data for this study were collected from a variety of sources, including government documents, university reports, global related entrepreneurship research websites (GEI, Global Entrepreneurship Monitor [GEM], 2019), and related journals (e.g., Entrepreneurship, Incubators, and University Incubators). Findings Synthetically, incubation centres possess the following primary missions: (1) they integrate professionals in various fields to promote industry partnerships and engagement; (2) they provide training to new entrepreneurs for achievement enhancement, mainly to help them acquire missing business knowledge; (3) they encourage start-ups to engage with one another in the culture of incubators, to enlist more people to join in supporting and expanding the society; (4) they commercialise intellectual properties and promote the commercialisation of inventions and innovations for the future market; (5) they bridge academic professors with industry entrepreneurs for technology upgrades and business transformation. To summarise, University Incubation Centres in Indonesia should strive to emulate the best practices of some Singaporean universities and do everything possible to help their tenants accelerate their entrepreneurial processes. In order to be competitive, an incubator must extend its network and partner with successful industries, funding agencies, industries, and universities.
Lipid-associated proteins

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Lipid-associated proteins are a relatively newly discovered class of proteins that are specifically associated with macromolecular lipid assemblies, other than bilayer membranes, in the cells of a wide range of organisms, from eubacteria to mammals. The vast majority of lipid-associated proteins in plants that have been described to date are intracellular. Oleosins are a class of relatively low molecular weight alkaline proteins of about 15–24 kDa that accumulate on the surfaces of lipid bodies in desiccation-tolerant seeds. Plastid lipid-associated proteins are localised exclusively in plastids and, like caleosins but unlike oleosins, they are not restricted to the Plantae but are also found in unicellular photosynthetic eukaryotes and homologues have even been found in cyanobacteria. The proteome of yeast lipid bodies has been systematically identified using electrospray mass spectrometry followed by an attempt at functional characterisation by deletion of the open reading frames corresponding to each identified protein.
[Mitochondrial genome analysis in the probands of six Chinese families with MELAS].

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is a genetically heterogeneous disorder. The most prevalent mitochondrial DNA (mtDNA) mutation associated with MELAS is the m.3243A>G transition in the mitochondrial tRNA(Leu(UUR)) gene. Here, we report the clinical, genetic and molecular characterization of six probands from Han Chinese families with MELAS. Four of six probands carried the heteroplasmic m.3243A>G mutation. The levels of mutation load ranged from 29% to 59%, which were correlated with the severity of the clinical phenotypes. Two probands with MELAS/Leigh overlap were 3243 A>G negative, whose severity and relapse were greater than the other 4 probands. One proband with MELAS/Leigh harbored the known ND5 m.13094T>C mutation, which is related to MELAS/Leigh overlap and cerebella ataxia. Sequence analysis of entire mtDNA showed the distinct sets of variants including some variants that may be associated with diabetes, hearing loss, seizures, cardiomyopathy, and Leigh syndrome. Our data suggested that the phenotype and severity of MELAS mainly depend on the mutation load, and some variants may partially contribute to the phenotype and diversity. Our finding also highlighted the complexity of the relationship between genotype and phenotype in MELAS.
Fine-grain access control for distributed shared memory

Field: Computer Science (Physical Sciences)

This paper discusses implementations of fine-grain memory access control, which selectively restricts reads and writes to cache-block-sized memory regions. Fine-grain access control forms the basis of efficient cache-coherent shared memory. This paper focuses on low-cost implementations that require little or no additional hardware. These techniques permit efficient implementation of shared memory on a wide range of parallel systems, thereby providing shared-memory codes with a portability previously limited to message passing.
Hazards associated with filling and emptying flexible intermediate bulk containers

Field: Chemical Engineering (Physical Sciences)

The use of flexible intermediate bulk containers (FIBC) for storage and transport of powders becomes more frequent and the number of fires or explosions reported is increasing. In a systematic hazard analysis the charge on the bulked product as well as the charge on the FIBC must be considered. As far as the explosion atmosphere is concerned again both the atmosphere in the FIBC and the atmosphere in the surroundings must be analysed. >
Access and Laws in the Management of Archival Informations

Field: Social Sciences (Social Sciences)

Explores and discusses archival informational management practices with emphasis on access and legal devices. Uses for this, both the scientific literature an the Regulatory Ordinance No. 3 of the Ministry of Planning, Budget and Management. Contextualizes the debate on the role of the state in relation to the protection and availability of government information to citizens, respecting the confidentiality restrictions, by Laws No. 12,527 and Law No. 8,159. Case study illustrates how the strategic management actions archival information from the functional collection of the Federal University of Pernambuco. Concludes, as a first approximation on the subject, that this type of management, despite the positive current changes, demand that the look on static stored collections of public institutions is revisited and directed to the provision of access to information in a dynamic flow and uninterrupted.
Morphological Changes and Cellular Uptake of Functionalized Graphene Oxide Loaded with Protocatechuic Acid and Folic Acid in Hepatocellular Carcinoma Cancer Cell

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The development of nanocomposites has swiftly changed the horizon of drug delivery systems in defining a new platform. Major understanding of the interaction of nanocomposites with cells and how the interaction influences intracellular uptake is an important aspect to study in order to ensure successful utilisation of the nanocomposites. Studies have suggested that the nanocomposites' ability to permeate into biological cells is attributable to their well-defined physicochemical properties with nanoscale size, which is relevant to the nanoscale components of biology and cellular organelles. The functionalized graphene oxide coated with polyethylene glycol, loaded with protocatechuic acid and folic acid (GOP-PCA-FA) nanocomposite intracellular uptake was analysed using transmission electron microscope. The accumulation of fluorescent-labelled nanocomposites in the HepG2 cell was also analysed using a fluorescent microscope. In vitro cellular uptake showed that there was uptake of the drug from 24 h into the cells and the release study using fluorescently tagged nanocomposite demonstrated that release and accumulation were observed at 24 h and 48 h. Moreover, the migration ability of tumor cells is a key step in tumor progression which was observed 48 h after treatment. The GOP serves as a potential nanocarrier system which is capable of improving the therapeutic efficacy of drugs and biomolecules in medical as well as pharmaceutical applications through the enhanced intracellular release and accumulation of the encapsulated drugs. Nonetheless, it is essential to analyse the translocation of our newly developed GOP-PCA-FA, and its efficiency for drug delivery, effective cellular uptake, and abundant intracellular accumulation would be compromised by possible untoward side effects.
Steffensen's Integral Inequality for the Sugeno Integral

Field: Mathematics (Physical Sciences)

In this paper we consider Steffensen's integral inequality for the Sugeno integral [Formula: see text] where f is a nonincreasing and convex function defined on [0, 1] with f(0) = 1, f(1) = 0 and g is a nonincreasing function defined on [0, 1] where 0 ≤ g(t) ≤ 1 for all t ∈ [a, b] with [Formula: see text]
LvCD14L Acts as a Novel Pattern Recognition Receptor and a Regulator of the Toll Signaling Pathway in Shrimp

Field: Immunology and Microbiology (Life Sciences)

Leucine-rich repeat (LRR) is a structural motif has important recognition function in immune receptors, such as Tolls and NOD-like receptors (NLRs). The immune-related LRR proteins can be divided into two categories, LRR-containing proteins and LRR-only proteins. The latter contain LRR motifs while they are without other functional domains. However, the functional mechanisms of the LRR-only proteins were still unclear in invertebrates. Here, we identified a gene encoding a secretory LRR-only protein, which possessed similarity with vertebrate CD14 and was designated as LvCD14L, from the Pacific whiteleg shrimp Litopenaeus vannamei. Its transcripts in shrimp hemocytes were apparently responsive to the infection of Vibrio parahaemolyticus. Knockdown of LvCD14L with dsRNA resulted in significant increase of the viable bacteria in the hepatopancreas of shrimp upon V. parahaemolyticus infection. Further functional studies revealed that LvCD14L could bind to microorganisms’ PAMPs, showed interaction with LvToll1 and LvToll2, and regulated the expression of LvDorsal and LvALF2 in hemocytes. These results suggest that LvCD14L functions as a pattern recognition receptor and activates the NF-κB pathway through interaction with LvTolls. The present study reveals a shrimp LvCD14L-Tolls-NF-κB signaling pathway like the CD14/TLR4/NF-κB signaling pathway in mammalians, which enriches the functional mechanism of secretory LRR-only immune receptors during pathogens infection in invertebrates.
Adolescents and MP3 Players: Too Many Risks, Too Few Precautions

Field: Health Professions (Health Sciences)

OBJECTIVE. The goal was to assess risky and protective listening behaviors of adolescent users of MP3 players and the association of these behaviors with demographic characteristics and frequency of use. METHODS. In 2007, 1687 adolescents (12–19 years of age) in 68 classes in 15 Dutch secondary schools were invited to complete questionnaires about their music-listening behaviors. RESULTS. Ninety percent of participants reported listening to music through earphones on MP3 players; 32.8% were frequent users, 48.0% used high volume settings, and only 6.8% always or nearly always used a noise-limiter. Frequent users were &gt;4 times more likely to listen to high-volume music than were infrequent users, and adolescents in practical prevocational schools were more than twice as likely to listen to high-volume music as were those attending preuniversity education. CONCLUSIONS. When using MP3 players, adolescents are very likely to engage in risky listening behaviors and are unlikely to seek protection. Frequent MP3 player use is an indicator of other risky listening behaviors, such as listening at high volumes and failing to use noise-limiters.