PD31-04 DO ENVIRONMENTAL FACTORS MODIFY THE GENETIC RISK OF PROSTATE CANCER?

Field: Medicine (Health Sciences)

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History I1 Apr 2014PD31-04 DO ENVIRONMENTAL FACTORS MODIFY THE GENETIC RISK OF PROSTATE CANCER? Stacy Loeb, Sarah Peskoe, Corinne Joshu, Wen-Yi Huang, Richard Hayes, H. Ballentine Carter, William Isaacs, and Elizabeth Platz Stacy LoebStacy Loeb More articles by this author , Sarah PeskoeSarah Peskoe More articles by this author , Corinne JoshuCorinne Joshu More articles by this author , Wen-Yi HuangWen-Yi Huang More articles by this author , Richard HayesRichard Hayes More articles by this author , H. Ballentine CarterH. Ballentine Carter More articles by this author , William IsaacsWilliam Isaacs More articles by this author , and Elizabeth PlatzElizabeth Platz More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2263AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Accumulating evidence supports that polymorphisms (SNPs) across the genome influence prostate cancer risk. To what extent this genetic risk can be reduced by environmental factors is unknown. Thus, we evaluated effect modification by dietary, lifestyle, and other environmental factors of the association between 20 SNPs previously associated with prostate cancer susceptibility and the risk of total, advanced, and nonadvanced prostate cancer. METHODS We performed a case-control study nested in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer screening trial. A genetic risk score was calculated for each man based on number of risk alleles for the 20 SNPs. Environmental factors were measured by questionnaire. We used logistic regression to estimate the association between higher genetic risk (≥12 risk alleles) and prostate cancer within strata of environmental factors adjusting for age and education. RESULTS Men with ≥12 risk alleles had 1.5-2.3 times the odds of total, advanced, and nonadvanced prostate cancer. These associations were attenuated with aspirin, ibuprofen, and selenium supplement use and with higher vegetable intake. For aspirin, the attenuation was the most marked for nonadvanced disease: compared to men with <12 risk alleles and who did not use aspirin, the odds ratio (OR) for ≥12 risk alleles was 2.25 (95% confidence interval [CI] 1.69-3.00) in nonusers and 1.70 (95% CI 1.25-2.32) in users (P-interaction=0.009). This pattern was similar for ibuprofen use (P-interaction=0.023) and vegetable intake (P-interaction=0.010). For selenium, the attenuation was the most striking for advanced disease: compared to men with <12 risk alleles and who did not use a selenium supplement, the OR for ≥12 risk alleles was 2.06 (95% CI 1.67-2.55) in nonusers and 0.99 (95% CI 0.38-2.58) in users (P-interaction=0.03). CONCLUSIONS This prospective study suggests that aspirin, ibuprofen and vegetable intake may attenuate the genetic risk of nonaggressive prostate cancer and that selenium supplement use may reduce the genetic risk of advanced prostate cancer. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e832 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Stacy Loeb More articles by this author Sarah Peskoe More articles by this author Corinne Joshu More articles by this author Wen-Yi Huang More articles by this author Richard Hayes More articles by this author H. Ballentine Carter More articles by this author William Isaacs More articles by this author Elizabeth Platz More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...