jimnoneill/paper-to-field-training huggingface dataset:
Drug discovery for DNA break repair system by screening from TCM database and molecular dynamics approach

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

In search for novel anti-tumour agents targeting non-homologous end joining pathway, we conducted a virtual screening using traditional Chinese medicine (TCM) on Ku heterodimer which plays an important role on DNA break repair system. Docking results gave glycyrrhizic acid and macedonoside C as potential TCM candidates. Both glycyrrhizic acid and macedonoside C were docked onto the Ku heterodimer with high-predicted binding affinities as evidenced in their Dock Score. These two ligands also interact with key residues which have been previously shown to influence Ku DNA-binding affinity. Both compounds show consistent hydrogen bonding interactions with key residues throughout the 10- ns dynamics simulation run. Furthermore, glycyrrhizic acid and macedonoside C are able to form additional hydrogen bond interactions with positively charged Ku heterodimer surface. Such interactions strengthen the binding interaction of the top two TCM compounds with Ku heterodimer. Glycyrrhizic acid and macedonoside C are products of licorice (Glycyrrhiza glabra), which is a commonly used herb in TCM formulations. Overall, we report glycyrrhizic acid and macedonoside C as potential anti-tumour agents.
An engineering introductory seminar course for first-year college students

Field: Engineering (Physical Sciences)

To help first year students adapt to their college lives and to enhance student learning, freshman seminar courses have been popular in many advanced countries. However, seminar courses in China are still in the beginning stage and are mainly for elective courses considering the large number of students in many majors. In this paper, implementation of a new required freshman seminar course, "Introduction to learning in the specialty of electronics and information" in Southeast University, is introduced. The course is composed of three education stages, i.e., lecture, investigation and project, during which the students can have closer and closer views to the applications of electronic science and engineering, and gain in-depth experience of relevant projects step by step. In addition, by making use of flexible class forms, various teaching methods, composite evaluation methods, and collaboration of a teacher team, the seminar course has been successfully run for about 170 students for the first time.
Correlation between Creative Tourism and Agrotourism Services Experiences: An Empirical Research in the Mexican Rural Tourism Environment

Field: Social Sciences (Social Sciences)

There is an immediate need to promote rural areas, where Mexico’s highest poverty is concentrated, but the most potential exists for future development. The preferences of the new modern tourist are based mainly on living experiences rather than just sights and souvenirs. The creative experience as the basis of Creative Tourism can be adopted by agrotourism, a type of Rural Tourism, that consist of tourist activities which are based on experiences that natives in the rural area experience on a daily basis. Thirty tourists from 18 to 23 years of age participated in agrotourism activities such as ointment workshops, food workshops, pulque (an alcoholic beverage made from the fermented sap of the maguey- agaveplant) preparation workshops, embroidery workshops, farming workshops, and a guided trip to the ecological reserve. With the use of narratives, experience maps, and audiovisual materials, the results show that the essence of Creative Tourism was understood as active participation and creativity. Many of the participants expressed novelty as a written and graphic expression of creative tourism which enabled them to have a better overall experience. This finding suggests that agrotourism should include different aspects of creative tourism as part of a “creative experience” for those in charge of the tourism industry in Mexico.
A Simple Method for Resolution ofEndo‐/Exo‐Monoesters ofTrans‐Norborn‐5‐Ene‐2,3‐Dicarboxylic Acids Into Their Enantiomers

Field: Chemistry (Physical Sciences)

Abstract Separation of optical isomers obtainable from trans ‐norborn‐5‐ene‐2,3‐dicarboxylic acid methyl and tert ‐butyl monoesters was performed by crystallization of the respective salts prepared with ( R )‐ and ( S )‐1‐phenylethylamine. Starting from racemic endo ‐monomethyl ester of trans ‐norborn‐5‐ene‐2,3‐dicarboxylic acid, prepared by partial hydrolysis of the cyclopentadiene‐dimethyl fumarate adduct, the corresponding (2 R ,3 R )‐ endo ‐monoester was isolated in 97% enantiomeric excess (ee) yield after seven repeated crystallizations from tetrachloromethane. Starting from exo ‐mono‐ tert ‐butyl ester of the same acid, prepared by alcoholysis of the cyclopentadiene‐maleic anhydride adduct followed by isomerization, (2 R ,3 R )‐ exo ‐monoester was isolated in >98% ee yield after four repeated crystallizations from ethanol. Crystallization of the acids from the mother liquor containing ( S )‐1‐phenylethylamine yielded products with inverse stereochemical configuration. Chirality 27:151–155, 2015 . © 2014 Wiley Periodicals, Inc.
The Values of Serum and Ascetic Fluid Tumor Necrosis Factor-Alpha (TNF- alpha), TNF-Receptor 1 and C-Reactive Protein (CRP) in Patients with Cirrhotic Ascites

Field: Medicine (Health Sciences)

Spontaneous bacterial peritonitis (SBP) is defined as an infection of initially sterile ascitic fluid (AF) without a detectable, surgically treatable source of infection. It is a frequent and severe complication of cirrhotic ascites. Because of the high morbidity and mortality of SBP, the rapid and accurate diagnosis is required.
Aggregation Indices of Cotton Arthropods in Texas1

Field: Agricultural and Biological Sciences (Life Sciences)

Journal Article Aggregation Indices of Cotton Arthropods in Texas Get access Edward P. Pieters, Edward P. Pieters Dept. of Entomology, Texas A&M University, College Station, TX 77843 Search for other works by this author on: Oxford Academic PubMed Google Scholar Winfield L. Sterling Winfield L. Sterling Dept. of Entomology, Texas A&M University, College Station, TX 77843 Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 3, Issue 4, 1 August 1974, Pages 598–600, https://doi.org/10.1093/ee/3.4.598 Published: 01 August 1974 Article history Received: 04 December 1973 Published: 01 August 1974
1 (under second review at the Journal of Marketing Research) Memory-Based Comparison Standards: Decomposing the Effects of Ease and Magnitude

Field: Psychology (Social Sciences)

of the dissertation of the first author under the supervision of the second. The authors gratefully acknowledge helpful comments and suggestions from the dissertation co-chair, Vicki Morwitz, and the dissertation committee members, Amitav Chakravarti, Tom Meyvis, Yaacov Trope, and Russell Winer. We would also like to gratefully acknowledge the invaluable input and guidance provided by the late JMR Editor, Dick Wittink. 2
Genotypes A and B of Cadophora gregata Differ in Ability to Colonize Susceptible Soybean

Field: Agricultural and Biological Sciences (Life Sciences)

Growth chamber experiments were conducted to determine if extent of colonization of soybean stems by genotypes A and B of Cadophora gregata (Phialophora gregata), the causal agent of brown stem rot (BSR) of soybean, is similar in soybean plants resistant or susceptible to genotype A. Upon introduction of the two genotypes separately into the base of stems of 2-week-old seedlings, genotype A advanced with the growing tips of susceptible but not resistant genotypes. In contrast, genotype B did not advance with the growing tips of either resistant or susceptible soybean. In similar experiments, 5 weeks after introduction of genotype A, both mean percent stem length colonized by C. gregata and mean percentage of symptomatic trifoliate leaflets were significantly less for resistant than for susceptible genotypes. For genotype B, there was no or a slight difference between resistant and susceptible soybean genotypes in mean percent stem length colonized and no difference in mean percentage of symptomatic trifoliate leaflets 5 weeks after introduction of the pathogen. These results indicate that genotype A and genotype B differ not only in the severity of foliar symptoms they cause on genotype A-susceptible soybean plants, but also in how severely they colonize the stems of these soybean plants. In our experiments, genotype A and genotype B did not differ consistently in their ability to cause internal stem discoloration. The two genotypes of C. gregata can be distinguished based on how severely they colonize stems of genotype A-susceptible soybean. Thus, a BSR resistance screening method, which relies on assessment of stem colonization by C. gregata, works only for screening soybean lines resistance to genotype A. In light of these results, it is important to distinguish soybean resistance to genotype A versus genotype B of C. gregata. Whether genotype B causes yield loss and whether soybean plants can be distinguished as resistant or susceptible to genotype B needs to be investigated.
It’s Not As Easy as They Say: International Students’ Perspectives About Gaining Canadian Work Experience

Field: Social Sciences (Social Sciences)

This study provides insights into international students’ perspectives of preparing for entry into employment in the Canadian workforce. From a human capital perspective, international students are valuable resources for the Canadian labour market and other countries where populations are in decline. However, most research on international students has focused on their initial transition experience, and available research on their employment experiences is often limited to the post-graduation transition. International students need to build their capacity for employment concurrently while they are studying, gaining local work experience. In this article we present an analysis of critical incidents collected from international students which highlights five key barriers in their experience of the Canadian work context, including policies and procedures, competition and economic conditions, challenges for navigating local cultural norms, language abilities, and their personal life circumstances. The discussion draws connections between international student recruitment and their longer-term goals for residency in Canada, with recommendations for bridging policies and services.
Eternal Duration: Milton on God's Justice in Everlasting Time

Field: Arts and Humanities (Social Sciences)

ABSTRACT Orthodox theology generally holds that God is eternal, which means that he exists in a state of absolute timelessness. John Milton, however, believed that God experiences the passage of time just as angels and humans do, except that God has always existed and that time extends infinitely into the past. Both Milton's Christian Doctrine and Art of Logic indicate that God exists in time. In Paradise Lost Milton tends to use the language of eternity metaphorically rather than literally, and he never uses such language to describe timelessness. His depiction of God the Father existing and acting in time is not a concession to the limitations of narrative; Milton believed that God actually exists in time. Milton's conception of time and eternity is not widely acknowledged, but it is essential to his insistence on radical free will and to his mythopoetic efforts to justify God's providence.
Toward a Method for Evaluating the Teaching of Entrepreneurship

Field: Business, Management and Accounting (Social Sciences)

The aim of this paper is to propose a method for evaluating the teaching of entrepreneurship. Indeed, by studying the theory and international experience in the field of entrepreneurship education, we noticed the absence of a universal consensus on a clear and consistent evaluation method, which led us to propose a method based on three pillars namely: the fixed objectives to this teaching, the concerned public and the deployed pedagogy. It seems that this method is clear and easy to apply when compared to existing methods in theory.
THE IMPACT OF WORK PRESSURES ON JOB PERFORMANCE WITHIN THE MODIFIED ROLE OF INNOVATIVE E CAPABILITIES: APPLIED STUDY IN IRAQI UNIVERSITIES

Field: Business, Management and Accounting (Social Sciences)

Purpose: The current study aimed to measure the impact of work pressure on the level of job performance in Iraqi universities within the framework of the enhancing role of innovative capabilities. Design/Methodology/Approach: Relying on a random sample of (294) respondents from senior, middle and supervisory management employees from four Iraqi universities, 23.9% of the total study population. Findings: The study found a low level of work stress in Iraqi universities & In return there is a high level of innovative capacity of those working in these universities, And a further increase in their level of job performance. In addition to the direct negative impact of work pressure on the level of job performance. This is in return for a direct positive effect of innovative ability on the level of job performance of employees in Iraqi universities. On the other hand, the coefficient of the interactive variable (innovative capacity × work pressure) was not statistically significant. Research, Practical & Social Implications: Simply controlling innovative capabilities has reduced the negative impact of work pressures from large to small. While innovative capabilities will have a significant positive impact on job performance. This means that the mere availability of innovative capabilities among workers will allow them to exploit them to avoid work pressures and reduce their negative impact on them. Originality/Value: This confirms the great practical importance of innovative capabilities in neutralizing the negative effects of work pressures on the job performance of employees in Iraqi universities. This gives a strong support for developing the theory and building policies to control work pressures by working to increase the innovative capabilities of workers.
Advances in Tightly Coupled Reservoir/ Wellbore/Surface-Network Simulation

Field: Energy (Physical Sciences)

Summary One of the most perplexing and difficult challenges in the industry is deciding how to develop a new oil or gas field. It is necessary to estimate recoverable reserves, design the most efficient exploitation strategy, decide where and when to drill wells and install surface facilities, and predict the rate of production. This requires a clear understanding of energy distribution and fluid movements throughout the entire system, under any given operational scenario or market-demand situation. Even after a reservoir-development plan is selected, there are many possible facility designs, each with different investment and operating costs. An important, but not always considered, fact is that each facility scheme could result in different future production rates owing to various types, sizes, and configurations of fluid-flow facilities. Selecting the best design for the asset requires the most accurate production forecasts possible over the forecast life cycle. No other single technology has the ability to provide this insight, as well as tightly coupled reservoir and facility simulation, because it combines all pertinent geological and engineering data into a single, comprehensive, dynamic model of the entire oilfield flow system. An integrated oilfield simulation system accounts for all dynamic flow effects and provides a test environment for quickly and accurately comparing alternative designs. This paper provides a brief background of this technology and gives a review of a major development project where it is currently being applied. Finally, we describe some recent significant advances in the technology that make it more stable, accurate, and rigorous.
Analysis of drug resistance status of mycobacterium tuberculosis in Quzhou from 2011 to 2012

Field: Medicine (Health Sciences)

Objective To monitor the drug resistance situation of mycobacterium tuberculosis,in order to obtain the information of initial drug resistance,acquired drug resistance and multidrug resistance and provide theoretical basis for development of TB control countermeasures. Methods Sputum mycobacterium tuberculosis were collected from new- diagnosed TB patients and retreated smear- positive patients in the TB designated hospitals in Quzhou between January 1,2011 and December 31,2012 for culture,then drug resistant test was conducted on the positive culture specimens using proportional method to test six anti- TB drugs(H,R,E,S,KM,OFX). Results A total of 890 TB patients were included,the total drug resistance rate of first-line drugs(H,R,E and S) was 15. 96%(142 /890),initial drug resistance rate was 12. 78%(102 /798),acquired drug resistance rate was 43. 78%(40 /92),multidrug resistant rate was 3. 82%(34 /890),and extensively multi- drug resistance rate was 0. 22%(2 /890). Conclusion Drug- resistant TB has threatened the health of people in Quzhou,so more attention should be paid to MDR- TB control.
Photoionization and Ion-Radical Decay of Anthracene in a Water Swollen Nafion Network. Effect of Different Counterions on the SO3-−Water Clusters

Field: Chemistry (Physical Sciences)

The formation of anthracene ion radicals in the H + -, Na + -, Fe 2 + -, and Fe 3 + -Nafion membrane was established by laser kinetic spectroscopy. The formation of ion radicals was observed to be due to (1) the two photon ionization of the anthracene molecule with the formation of the radical cation An + . radical and a fast electron scavenging by H + , Na + , Fe 2 + , and Fe 3 + acting as efficient electron traps in solution and (2) the quenching of the excited anthracene by Fe 3 + that leads by a redox process to the formation of An + . and Fe 2 + . It is shown that the ensuing kinetics of the ion-radical decay depends on the chemical nature of the traps. The lifetime of T An becomes shorter after Fe 2 + or Fe 3 + is introduced in the Nafion. The steady-state anthracene fluorescence is quenched by Fe 3 + or Fe 2 + and followed the logarithmic decay law ln(I 0 /I) where the decay in solution was seen to be proportional to the [Fe 3 + ] or [Fe 2 + ]. The counterions of SO 3 - -water clusters as well as of oxygen in the reaction media strongly affect the kinetics of ion-radical reactions occurring in the Nafion membrane. The counterions and oxygen are suggested to be the traps for the generated electrons in solution. The excited state of An was shown to react with Fe 3 + through electron transfer. Triplet excited anthracene molecules are quenched by Fe 3 + and Fe 2 + with rate constants k q (Fe 3 + ) = (1.9 ′ 0.19) × 10 8 M - 1 s - 1 and k q (Fe 2 + ) = (1.4 ′ 0.11) × 10 9 M - 1 s - 1 . Anthracene ion radicals are formed in the reaction with Fe 3 + but not with Fe 2 + on thermodynamic grounds. Fe 2 + or Fe 3 + being different chemical species quench with similar rates the An probe inside the Nafion membrane. Treatment of Fe 3 + -Nafion with NaOH leads to precipitation of iron particles in the membrane having as consequences (1) the decrease of the observed rate for the triplet excited anthracene quenching with a concomitant decrease in the observed An + . yields and (2) a significant decrease of the An + . decay time because of the lowering of the mobility of the iron ions in solution.
Influence of moisture on rate of decay of loblolly pine root wood by Heterobasidion annosum

Field: Agricultural and Biological Sciences (Life Sciences)

Root segments of loblolly pine (Pinus taeda L.) were decayed by Heterobasidion annosum (Fr.) Bref. (=Fomes annosus (Fr.) Karst.) over a broad range of wood (33–317%) and soil (36–259%) moisture contents in modified soil-block tests. Maximum weight loss occurred at 50–286% wood moisture content. Decay was inhibited at wood moisture contents over 290%. Water moved rapidly into the root segments by capillarity, and some decay occurred within 2 weeks. Water uptake was faster in inoculated segments than in noninoculated segments at a soil moisture content of 172% of the 0.2 bar (1 bar = 100 kPa) moisture content.
Sustainable Agricultural Land Management in Garut Regency, West Java Province, Indonesia

Field: Agricultural and Biological Sciences (Life Sciences)

The high land conversion rate to other sectors has led the government to issue Law No. 41 in 2009 concerning Protection of Sustainable Agricultural Land (SAL). The study aims to identify the distribution of sustainable agricultural land uses and determine agricultural land-use changes from 2016 to 2019 and determine farmers' understanding of sustainable agricultural land control in the strategic area of Garut Regency. We overlaid the land use maps of Garut Regency in 2016 and 2019 and conducted a survey using an online questionnaire with a Google form. The research location is in five districts in Garut Regency. The results showed no land conversion in the area of existing sustainable agricultural land in Garut Regency. The total rice field area is 6,081 hectares, with about 24% is sustainable agricultural land. From 2016 to 2019, the rice field area decreased by 12 hectares. The farmers' awareness of SAL tends to be more likely aware of the sustainable agricultural land area, as many as 39% of farmers aware of sustainable agricultural land. The incentives given to farmers who control sustainable agricultural land are tax deduction, agricultural infrastructure supply, agricultural production facilities subsidies, and land certification facilities. The majority of the respondents are aware of these incentives. In conclusion, no sustainable agricultural land is converted, even though changes occur in non-sustainable agricultural land. The impact of this study is for recommendations to the government in sustainable agricultural land management.
Drug Pricing Transparency: The New Retail Revolution

Field: Health Professions (Health Sciences)

As spending on medications in the United States increases with each passing year, the need for drug pricing transparency by manufacturers also increases. Drug spending, excluding rebates and discounts, was $309.5 billion in 2015, up 8.5% from 2014. Drug pricing transparency has been a topic of debate across the health care system. This column reviews the issue of drug pricing and emphasizes the need for transparency in this area. We will discuss factors that influence drug pricing, policies and ways to reduce the rising costs of drugs, and the role of pharmacy leaders in managing this problem. A multitude of factors are driving the country to spend more and more on medications; pharmacy leaders can employ various strategies to counteract this escalation of drug prices. After reviewing this article, the pharmacy director will have an increased ability to address drug pricing issues with stakeholders as they develop patient-centered pharmacy services.