jimnoneill/paper-to-field-training huggingface dataset:
Evaluation of wound‑healing effect of Ziziphus mauritiana L. leaf extract in rats

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background: Ziziphus mauritiana L. leaves are used traditionally for burns, wounds, inflamed parts, hypertension and as a diuretic. Objective: To evaluate the wound‑healing property of ethanol extract of Ziziphus mauritiana L. leaf (EEZM) on rats using excision, incision and dead space wound models. Materials and Methods: Wistar albino rats (150 − 200 gm) were divided into four groups (n = 6). Group I (control) animals received no treatment, group II animals were given EEZM 300 mg/kg orally, group III animals were applied EEZM gel, 100 mg/cm2 and group IV animals were applied Framycetin skin cream, 100 mg/cm2 topically. In incision and dead space wound models, the treatment was given for 10 days only from the day of wound, skin‑breaking strength and dry granulation tissue weight were estimated in incision wound model. Hydroxyproline content was estimated in dead space wound model. In excision wound model, treatment continued till the complete healing of the wound. Rate of wound contraction and period of epithelisation was evaluated thereafter. The data was analyzed by one‑way ANOVA, followed by Dunnett’s test. P <0.05 is considered significant. Results: EEZM increased the rate of wound contraction, decreased period of epithelisation, increased skin‑breaking strength and dry granulation tissue weight, elevated hydroxyproline content. Conclusion: Ziziphus mauritiana possesses wound healing activity. Key words: Period of epithelisation, skin breaking strength, wound healing, wound contraction, Ziziphus mauritiana
SYMBOL ANALYSIS OF THE WEKASAN REBO TRADITION AND TRUST OF THE JAPANESE VILLAGE COMMUNITY, MEJOBO DISTRICT, KUDUS REGENCY

Field: Social Sciences (Social Sciences)

Java is one of the areas that is rich in culture and since hundreds of years ago the Javanese people have carried out the culture of their ancestors so that the Javanese people are very familiar with local culture and including the mysticism of culture itself. This cultural diversity then encourages researchers to conduct in-depth research related to the traditions or culture of the Javanese people, especially the Rebo Wekasan tradition in the Japanese village community. This tradition is still preserved and commemorated by the community every last Wednesday in the month of Safar and in its current development the tradition is commemorated for several days with a series of various religious activities. Specifically, this study examines the symbolic aspects contained in the Rebo Wekasan tradition and how the Japanese Village community believes in the tradition to maintain it to this day.
New erymid lobsters from the Nusplingen and Usseltal formations (Upper Jurassic) of southwest Germany

Field: Earth and Planetary Sciences (Physical Sciences)

Two new species of Late Jurassic erymid lobsters, Stenodactylina devillezi sp. nov. and Stenodactylina geigerae sp. nov., are described on the basis of isolated, but well-preserved chelipeds from the upper Kimmeridgian of Swabia and the lower Tithonian of Bavaria, respectively. The incomplete nature of the material indicates that these lobsters were not autochthonous elements of the Plattenkalk lagoons, but resulted from predation in nearby shallow-water settings.
More than 4,000 new titles are being added to ABS web site

Field: Social Sciences (Social Sciences)

The Australian Bureau of Statistics (ABS) has added more than 4,000 extra publications to its collection of free online publications. The set of mainly historical material includes all ABS publications, national and regional titles, released during 1994, 1995, 1996 and 1997 including the Australia and State Year Books. With the addition of this set, the ABS web site will now hold all ABS publications released from 1994 to the present day. This latest addition represents a 30% increase in the number of publications that people can view and download for free from the ABS web site at www.abs.gov.au. Head of the ABS Information Services, Kerrie Duff said the addition of the material was a large step forward in the ABS mission to encourage informed decision making in the community by making statistics available to the public. “It’s a massive amount of new information that is available online,” she said. “It represents four years of the work of the ABS and it will provide a rich resource for students of Australian social and economic history.” “In a real sense, with this move the digital age has captured some of the pre-digital past.” Some of these publications have been converted from older scanned images to pdf files. These historical publications will appear with all current publication pdf files and are treated as past issues when accessing them on the web site.
Notes. Potential Antimalarials. Some Novel α-(Disubstituted Aminomethyl)-9-phenanthrenemethanols

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes. Potential Antimalarials. Some Novel α-(Disubstituted Aminomethyl)-9-phenanthrenemethanolsK. Venkatramana Bhat, Silvano De Bernardo, and W. Werner ZorbachCite this: J. Med. Chem. 1969, 12, 3, 536–538Publication Date (Print):May 1, 1969Publication History Published online23 September 2003Published inissue 1 May 1969https://doi.org/10.1021/jm00303a620Request reuse permissions Article Views26Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (403 KB) Get e-Alertsclose Get e-Alerts
The reversal of epigenetic silencing of the EBV genome is regulated by viral bZIP protein

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

EBV (Epstein-Barr virus) alternates between latency and lytic replication. During latency, the viral genome is largely silenced by host-driven methylation of CpG motifs and in the switch to the lytic cycle this epigenetic silencing is overturned. A key event is the activation of the viral protein Zta with three ZREs (Zta-response elements) from the BRLF1 promoter (referred to as Rp). Two of these ZREs contain CpG motifs and are methylated in the latent genome. Biochemical analyses and molecular modelling of Zta bound to methylated RpZRE3 indicate the precise contacts made between a serine and a cysteine residue of Zta with methyl cytosines. A single point mutant of Zta, C189S, is defective in binding to the methylated ZREs both in vitro and in vivo. This was used to probe the functional relevance of the interaction. ZtaC189S was not able to activate Rp in a B-cell line, demonstrating the relevance of the interaction with methylated ZREs. This demonstrates that Zta plays a role in overturning the epigenetic control of viral latency.
Aging-Related Changes of the Kinetic Visual Field

Field: Medicine (Health Sciences)

Study of the kinetic visual field of humans and the effect of aging upon it is strongly needed in order to identify the cause of traffic accidents while focusing on these characteristics. In this paper, differences in the kinetic visual field between younger and older people were measured and analyzed after identifying problems with the conventional definition of the kinetic visual field and modifying the kinetic perimeter system. In addition, by measuring simple reaction time when the kinetic visual field is measured in order to minimize the effect of individual differences in response time, it was confirmed that older people are greatly affected by deteriorating visual performance caused by aging, particularly in upward visual field rather than downward visual fields in all target conditions. Visual field angle reductions in the temple sides of upward visual fields were of particular note.
Efficient heuristics for simulating rare events in queuing networks

Field: Decision Sciences (Social Sciences)

In this thesis we propose state-dependent importance sampling heuristics to estimate the probability of population overflow in queuing networks. These heuristics capture state-dependence along the boundaries (when one or more queues are almost empty) which is crucial for the asymptotic efficiency of the change of measure. The approach does not require difficult (and often intractable) mathematical analysis or costly optimization involved in adaptive importance sampling methodologies. Experimental results on tandem, parallel, feed-forward, and a 2-node feedback Jackson queuing networks as well as a 2-node tandem non-Markovian network suggest that the proposed heuristics yield asymptotically efficient estimators, sometimes with bounded relative error. For these queuing networks no state-independent importance sampling techniques are known to be efficient.
Strain‐Dependent Variations in Carotid Body O 2 Sensing: Role of CO‐H 2 S Signaling

Field: Neuroscience (Life Sciences)

Systemic responses to hypoxia vary among human subjects and in different strains of rats. We examined whether these inherent variations in hypoxic response to carotid body (CB) O 2 sensing and involve CO‐H 2 S signaling. Experiments were performed on age and gender matched Sprague‐Dawley (SD), Brown‐Norway (BN) and Spontaneous Hypertensive (SH) rats. Compared to SD, BN rats exhibited impaired carotid body response to hypoxia, and developed pulmonary edema as a consequence of poor ventilatory adaptation to hypobaric hypoxia. SH rat carotid bodies displayed inherent hypersensitivity to hypoxia and develop hypertension. BN CBs have higher CO and lower H 2 S levels than SD, while SH carotid bodies have reduced CO and greater H 2 S generation. Reducing CO levels in BN carotid body increased H 2 S generation, restoring CB hypoxic sensing and preventing high‐altitude pulmonary edema. Increasing CO levels in SH carotid bodies reduced H 2 S generation, preventing hypersensitivity to hypoxia and controlling hypertension. Supported by NIH‐HL‐90554.
IMMUNOGLOBULIN CONCENTRATIONS IN FIRST-DEGREE RELATIVES OF EPILEPTIC PATIENTS WITH DRUG-INDUCED IgA DEFICIENCY

Field: Medicine (Health Sciences)

Serum immunoglobulins A, G and M were studied in parents and siblings of 16 patients being treated for epilepsy. Five healthy families served as controls. Seven of the patients were low IgA-responders and the rest of the patients had shown normal IgA-levels during treatment. None of the parents and siblings studied showed a serum-IgA deficiency, with the exception of one mother who was being treated for rheumatoid arthritis with naproxen. Low serum concentrations of IgG and IgM were not found. A significantly increased IgM-level was found in first-degree relatives of the low IgA-responders, and the siblings of low 2gA-responders had significantly raised IgA in their sera.
INFLUENCE OF MAIN SOIL TILLAGE METHODS ON THE DYNAMICS OF SUGAR BEET ROOT WEIGHT GROWTH AND SUGAR ACCUMULATION IN THEM

Field: Agricultural and Biological Sciences (Life Sciences)

В статті висвітлені результати досліджень впливу способів основного обробітку ґрунту, які поширені в умовах недостатнього зволоження Лівобережного Лісостепу, на інтенсивність наростання маси коренеплодів буряків цукрових, їх гички, а також на процес цукронакопичення. Такі дослідження проводили у зернопросапній та зернопаропросапній сівозмінах, де застосовували найпоширеніші способи основного обробітку ґрунту. В результаті досліджень було встановлено, що у зернопросапній сівозміні маса 100 проростків, у середньому за три роки досліджень, була найбільшою у варіанті з оранкою на глибину 30–32 см і становила 41,8 г, що на 7,6 г більше, ніж на оранці з поглибленням до 40 см і на 3,0 г більше за варіант із ярусною оранкою. У зернопаропросапній сівозміні найкращі умови для початкового розвитку рослин буряків створились у разі поверхневого обробітку ґрунту на 10–12 см з розпушуванням його до 40 см. Найінтенсивніше наростання маси коренеплодів спостерігали в обох сівозмінах у варіантах із оранкою на 30–32 см – 3,7 та 4,4 г щодоби відповідно. У зернопаропросапній сівозміні наростання маси коренеплодів у другій половині вегетації відбувається інтенсивніше, ніж у зернопросапній. За серпень-вересень у варіанті з оранкою на глибину 30–32 см у зернопаропросапній сівозміні маса коренеплоду збільшилась на 262 г, у зернопросапній – на 221 г. Цукристість коренеплодів, у середньому за три роки досліджень, була максимальною в зернопаропросапній сівозміні у варіанта із плоскорізним обробітком ґрунту на 30–32 см і становила 18,7 %. Майже таким (18,6 %) вміст цукру в коренеплодах виявився у варіанта звичайної оранки на глибину 30-32 см і дещо меншим (18,1 %) – у варіанта поверхневого обробітку на глибину 10–12 см з розпушуванням на 40 см. У зернопросапній сівозміні цукристість коренеплодів значно поступалась відповідному показнику зернопаропросапної сівозміни. Проте, у варіанті з оранкою на глибину 30 см з поглибленням до 40 см отримали коренеплоди буряків із вмістом цукру на рівні 18,5 %.
EP25.03: External validation of risk prediction model M4: rationalising management of pregnancies of unknown location

Field: Medicine (Health Sciences)

A prediction model (M4) can successfully classify PUL into low and high risk groups. We aim to externally validate the M4 model in classifying women in a non-UK population, into low and high risk pregnancies of unknown location (PULs). A retrospective analysis of women classified with PUL attending a Sydney-based teaching hospital between June 2006 and March 2016. PUL was defined as nil signs of intra- or extra-uterine pregnancy on transvaginal ultrasound (TVS). The reference standard was the final characterisation of PUL as failed PULs or intra-uterine pregnancies (IUPs) (low risk), or as ectopic pregnancies (EPs) (high risk). M4 is a multinomial logistic regression model based on the serum human chorionic gonadotrophin (hCG) levels at presentation and 48 h later. This model was applied to each PUL and the estimated risks of failed PULs, IUPs or EPs were recorded. In the event that M4 classified women to have an EP risk ≥ 5%, then these women were classified high risk. 8360 consecutive women underwent TVS and 7.94% (664/8360 women were classified with a PUL. 57 women were excluded due to incomplete data. The final diagnoses were 64.4% (391/607) failed PULs, 23.5% (143/607) IUPs and 12% EPs (73/607; includes EPs and persisting PULs). 454 were considered low risk of which 397 (87.4% were failed PULs or IUPs) and 22 were EPs. 67% (49/73) of the EPs were considered high risk. The M4-based protocol classified 17.6% of failed PUL, 31% of IUP and 69% of EP as at high risk. For all PUL this protocol classified 69% of PUL as at low risk, and amongst these 95% were indeed failed PUL or IUP. Thus, of PUL classified as at low risk using M4, about 1 in 19 would be an EP. We have externally validated prediction model M4 which classified around 69% of PULs as low risk, of which around 95% were later characterised as failed PULs or IUPs, while still classifying 69% of EPs as high risk.
Off-effect in tone-burst evoked cochlear responses

Field: Neuroscience (Life Sciences)

The whole-nerve Action Potential (AP) and the single unit Post Stimulus Time histograms have been extensively investigated in relation to click stimulation and the on-response provoked by a tone-burst, but the off-response has never been studied in detail and no interpretation is available for these phenomena. The growth of an off-effect in the whole-nerve AP and in the single fiber discharge pattern at the end of a tone-burst is explained by means of some fundamental laws of the system dynamics. The available knowledge of the mechanisms of generation of the AP is sufficient enough to predict the dependence of the magnitude and of the shape of the off-AP on the burst paradigms (frequency, amplitude and phase). Simulations of a simple single fiber model are shown to predict off-responses with tone-bursts and sustained stimulations. On this basis, it is suggested that a better understanding of the single unit behavior is achieved by reproducing the model predictions by specially designed animal experiments.
Judgments and Measurements of the Loudness of Tinnitus before and after Masking

Field: Psychology (Social Sciences)

This study explored the relation between changes reported in the perception of the loudness of tinnitus after noise exposure and changes measured in matches to the loudness of tinnitus after noise exposure. Preexposure assessment of the loudness of tinnitus was followed by monaural exposure to wide-band Gaussian noise (for a 5-min period), after which a pulsed, 200-ms tone was presented either ipsilateral or contralateral to the exposed ear. Following each noise exposure, the subject (a) judged the change in the pre- and postexposure tinnitus strength and (b) compared the loudness of the postexposure tinnitus to that of the pure tone. By combining data across noise exposures, a measure of the postexposure tinnitus magnitude was computed. For three of six subjects, the pre- and postexposure magnitude did not differ significantly even though the judgments indicated that the pre- and postexposure loudness of the tinnitus had changed. These data raise the possibility that some loudness judgments reflect variability in the tinnitus rather than the effect of the noise on the tinnitus.
The lifetime risk of revision following total knee arthroplasty

Field: Medicine (Health Sciences)

Aims The success of total knee arthroplasty (TKA) is usually measured using functional outcome scores and revision-free survivorship. However, reporting the lifetime risk of revision may be more meaningful to patients when gauging risks, especially in younger patients. We aimed to assess the lifetime risk of revision for patients in different age categories at the time of undergoing primary TKA. Methods The New Zealand Joint Registry database was used to obtain revision rates, mortality, and the indications for revision for all primary TKAs performed during an 18-year period between January 1999 and December 2016. Patients were stratified into age groups at the time of the initial TKA, and the lifetime risk of revision was calculated according to age, sex, and the American Society of Anesthesiologists (ASA) grade. The most common indications for revision were also analyzed for each age group. Results The overall ten-year survival rate was 95.6%. This was lowest in the youngest age group (between 46 and 50 years) and increased sequentially with increasing age. The lifetime risk of requiring revision was 22.4% in those aged between 46 and 50 years at the time of the initial surgery, and decreased linearly with increasing age to 1.15% in those aged between 90 and 95 years at the time of surgery. Higher ASA grades were associated with increased lifetime risk of revision in all age groups. The three commonest indications for revision were aseptic loosening, infection, and unexplained pain. Young males, aged between 46 and 50 years, had the highest lifetime risk of revision (25.2%). Conclusion Lifetime risk of revision may be a more meaningful measure of outcome than implant survival at defined time periods when counselling patients prior to TKA. This study highlights the considerably higher lifetime risk of revision surgery for all indications, including infection, in younger male patients. Cite this article: Bone Joint J 2022;104-B(2):235–241.
Iliac vein compression.--Its relation to iliofemoral thrombosis and the post-thrombotic syndrome.

Field: Medicine (Health Sciences)

Summary The treatment of haemorrhoids by conservative methods has been examined. Injection therapy with the use of phenol in almond oil was effective in controlling bleeding, but with almond oil alone it was not. A comparison between the results of injection therapy and the technique of rubber ring ligation showed objectively better results after six months with ligations. However, ligation was sometimes followed by pain, and a few patients refused to continue with this form of treatment. These preliminary alternatives indicate that phenol in oil is still the best treatment for early first-degree piles. The results of ligation for second-degree piles are encouraging, but further evaluation is required.
Experimental-Numerical Investigation of Rotor-Rotor Aerodynamic Interactions for eVTOL Aircraft Configurations

Field: Engineering (Physical Sciences)

The paper presents the description of a research activity aimed to the systematic study of the rotor-rotor aerodynamic interaction with application to the flight conditions typical of eVTOL aircraft. The activity considers a dual effort, experimental and numerical, to gather systematic parametric data on different types of rotor-rotor interactions. In particular, the paper describes the planning and set up of a wind tunnel campaign aimed to evaluate the effects of the aerodynamic interactions on the rotor performance and flow field for two propeller models both in side-by-side and tandem configuration. Moreover, the results of numerical simulations performed with a mid-fidelity aerodynamic code on both the planned test configurations are presented showing the main effects of the aerodynamic interactions on the performance of the propeller.