jimnoneill/paper-to-field-training huggingface dataset:
O-22 How can communities support carers – developing community capacity and capability?

Field: Health Professions (Health Sciences)

In Ambitions for Palliative and End of Life Care (2015) Ambition 6 states that the aspiration is that 'Each community is prepared to help'. The range of terms used to describe this approach are based on the principle that care at the end of life should be done with people and not to people, that death, dying, loss and care are complex social events, in which the medical component is only one aspect. This paper outlines the outputs and future considerations from a series of workshops that took an Appreciative Inquiry Model (Definition, Discovery, Dream, Design, Delivery onto Destiny) approach to design, test and produce a local community development workshop 'toolkit' for anyone, not just professionals to use. The project, led by Hospice UK and commissioned by NHS England, resulted in a free online resource, a community of practice network (Source4Network) with a discussion site and a twitter community @ComDevCoP. The co-design group for the work brought together hospices that had already begun their development journey as community engagers. The work further substantiated that each community has unique challenges and idiosyncrasies, the resulting toolkit reflecting a flexible locality driven approach with the intent to increase the connectivity across sectors, communities, neighbourhoods and social networks. The co-design group of community engagers launched the tested tool kit in July 2019. It provides local communities an opportunity to harness the support of local interested members to provide improved community support for carers, those at the end of lives, going through a bereavement and/or lonely. The evaluation is ongoing and initial findings will be available by the Hospice UK conference in November 2019. Acknowledgements to the hospices that supported the process are within the Hospice UK website page and community development toolkit.
Corporate Governance and Cost of Equity: Do Financial Development and

Field: Economics, Econometrics and Finance (Social Sciences)

Extant research documents that firm level corporate governance attributes are associated with the cost of equity capital. Another strand of research provides evidence regarding the beneficial impact of superior legal institutions and regulations on the cost of equity. We contribute to this literature by jointly examining the relative effects of country level institutional and firm level governance attributes on the cost of capital. Using a comprehensive sample of 7380 firm years drawn from 22 developed countries, we show that firm level governance attributes affect the cost of equity capital only in common law countries with high level of financial development. Our study is the first one to highlight the complementary effects of legal origin, financial development and firm level governance attributes in influencing the cost of equity capital.
Characterisation and expression of a novel haplotype cry2A-type gene from Bacillus thuringiensis strain JF19-2

Field: Agricultural and Biological Sciences (Life Sciences)

The Bacillus thuringiensis isolate JF19-2, a native organism found in soil samples from the Sichuan Basin in western China, contains a bipyramidal crystal harbouring one insecticidal crystal protein (about 70 kDa). Interestingly, a novel cry2A-type gene, encoding a 635 amino acid protein with 92% homology to cry2Ab1, was found and cloned from this strain. According to the nomenclature principles adopted for B. thuringiensis insecticidal crystal proteins, this gene represents a novel haplotype cry gene and was designated as cry2Ag1 by the Bacillus thuringiensis Pesticide Crystal Protein Nomenclature Committee. Cry2Ag1 was expressed in Escherichia coli BL21(DE3)pLysS cells, and the results of insecticidal activity assays showed that Cry2Ag1 was toxic to both Dipteran (Aedes aegypti) and Lepidopteran (Plutella xylostella and Helicoverpa armigera) pests. These results strongly suggest that the cloning of the cry2Ag1 gene is not only of interest to researchers studying insecticidal crystal genes, but may ultimately serve as a solution to the increasing resistance of pests to currently used insecticides.
Study on expression of NO and iNOS in J774A. 1 cells induced by rVvhA

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Objective To investigate the effect of recombinant Vibrio vulnificus hemolysin (rVvhA) on the expression of nitric oxide(NO) and induced nitric oxide synthase(iNOS) in J774A. 1 cells.Methods The inhibitory effect of rVvhA on J774A. 1 proliferation was measured by MTF colorimetry technique. The content of nitrite in culture medium was determined by Griess reagent. The expression of iNOS protein and mRNA were measured by immunofluorescence and RT-PCR, respectively. Results The viability of J774A. 1 cells was apparently inhibited when exposed to 0.8 HU/ml rVvhA and up. With the help of IFN-γ, the expression of NO and the activity of iNOS in J774A. 1 cells were remarkably increased when exposed to 0.4 HU/ml rVvhA. Conclusion rVvhA can increase the expression of NO and iNOS, it may play an important role in the pathogenic mechanism of Vibrio vulnificus.

Key words:
Vibrio vulnificus; Cytolysin; J774A. 1; Nitric oxide; Induced nitric oxide synthase
24-Epibrassinolide from Gypsophila perfoliata

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract The scarce 24-epibrassinolide could be identified from seeds of Gypsophila perfoliata L. by GC/MS as the only brassinosteroid present. Furthermore, the Δ 7 -phyto-sterols ergost-7-en-3β-ol, spinasterol and 22-dihydro-spinasterol were found as main sterols in the same plant material.
Multi-stakeholder perspectives on approaches for addressing the incidence of urban public open space encroachment: The case of Freedom Square, Bloemfontein

Field: Social Sciences (Social Sciences)

Several studies have investigated the extinction of urban public open spaces in South Africa. However, a fixation by such studies on well-established primary cities has been noticed, whilst limited attention has been paid to emerging major cities. In addition, findings from these studies have resulted from the perspectives of either planning entities’ representatives or representatives of the communities associated with open space encroachment. This implies the absence of a systemic and multi-stakeholder engagement. This article contributes towards bridging these observed gaps through the elicitation of multi-stakeholder perspectives on the enablers of urban public open space encroachment in major cities, using a Mangaung Metropolitan exemplar. Adopting a qualitative case study research design, data were gathered using semi-structured interviews and focus-group interviews. Participants were purposively recruited from Mangaung Metropolitan Municipality planning department and community members residing in Freedom Square township, Bloemfontein. The data were analysed using thematic analysis. Significant enablers identified include low levels of sustainability literacy, low levels of citizen participation in the planning process, and planners’ inability to manage extant value conflicts. The findings from this study contribute to a broader study that seeks to develop an urban open space planning and management framework for forestalling the incidence of encroachment in major cities. Accordingly, this study’s findings have practical implications for relevant planning stakeholders who are keen on curbing the incidence of urban open space encroachment in South African townships.
Screening of bacterial isolates antagonists and suppressors of blast in rice plants

Field: Agricultural and Biological Sciences (Life Sciences)

ABSTRACT Grain yields of rice (Oryza sativa) are affected globally by rice blast (Magnaporthe oryzae). The main objective of this study was to identify isolates of rhizobacterial antagonists of M. oryzae (BRM10781) and screen the most effective isolates for suppressing rice blast under greenhouse conditions. Two assays (E1 and E2) were performed with 22 treatments in a completely randomized design with three replicates. E1 investigated in vitro antagonism between 21 isolates and M. oryzae under laboratory conditions. The E2 experiments were conducted under greenhouse conditions, with rice cultivar BRS Primavera seeds in plastic trays containing 3 kg of fertilized soil. After 21 days, the rice leaves were spray-inoculated with a bacterial cell suspension (1 × 108 CFU) and M. oryzae (3 × 105 conidia.mL-1) or with water (absolute control). Seven isolates, Serratia marcescens (BRM65918, BRM65923, BRM65926, and BRM63532), Bacillus cereus (BRM65919), Stenotrophomonas nitritireducens (BRM65917), and Priestia megaterium (BRM65929), reduced radial growth of M. oryzae colonies from 80.26 to 77.33%. The best leaf blast severity reducers were Pseudomonas nitroreducens (BRM32112), B. thuringiensis (BRM65928), P. megaterium (BRM65916), S. marcescens (BRM65918), S. nematodiphila (BRM63522), and Enterobacter hormaechei (BRM65925), varying from 97 to 95% respectively. The isolate BRM65918 (S. marcescens) showed the best efficiency for both antagonism and disease suppression, indicating its potential as a bioproduct for the biocontrol of rice blast in rice plants.
Gel-filtration chromatography data for L35Ae samples

Field: Chemistry (Physical Sciences)

Gel-filtration chromatography data for L35Ae samples (3.5-3.7 mg/ml) and molecular mass standards at room temperature (Superdex 75 10/300 GL column). The elution profiles of L35Ae samples are shown in the inset. The open circles corresponding to elution times of the mass standards were described by linear function (solid line). The apparent molecular masses of L35Ae samples were determined by comparison of their elution times with the calibration line, as indicated by dashed arrowed lines.
Avrupa Birliği’yle Hindistan Arasında Sonuçlanamayan Serbest Ticaret Anlaşması Müzakereleri: İki Seviyeli Oyun Analizi

Field: Social Sciences (Social Sciences)

This article examines the arduous free trade agreement negotiations between the European Union and India. The talks, which started in 2006 and were suspended for a while, could not lead to an agreement in more than 15 years. By employing the two-level game theory, developed by Robert Putnam, this article attempts to explore the role of the domestic realm on the extension of the negotiations. Therefore, it investigates the win-sets of the negotiating parties, by focusing on the domestic factors such as interest groups, political structure and political culture in order to determine which of these factors make it difficult to find common ground. On the basis of the said analysis regarding the free trade agreement negotiations between the European Union and India, this article further aims at finding out why trade negotiations pursued by the European Union usually require a long period of time.
Detection of CTX-M-Type Extended-Spectrum Beta-Lactamase Producing Salmonella Typhimurium in Commercial Poultry Farms in Copperbelt Province, Zambia

Field: Veterinary (Health Sciences)

In Zambia, poultry is a rapidly increasing sector contributing 4.8% of the Agricultural Gross Domestic Product (GDP), thus providing a significant income-generating activity. Worldwide, poultry is a major reservoir of Salmonella with an increasing incidence of extended-spectrum beta-lactamase (ESBL) producing strains. ESBLs are enzymes produced by bacteria and are capable of inactivating a wide range of beta-lactam antibiotics. Salmonella enterica serovars Enteritidis and Typhimurium are the most important foodborne serotypes in many countries, infecting both humans and animals and are transmitted to humans through the food supply chain. CTX-M ESBLs have been described in Salmonella Typhimurium isolates with resistant genes located on transferable plasmids. This study aimed to detect S. Typhimurium, their antimicrobial resistance, and CTX-M-type ESBL Producing strains in commercial poultry farms in Copperbelt Province, Zambia. Five districts were considered for this study, where one poultry farm per district was randomly selected for sampling. An overall number of 384 fecal samples were analyzed using microbiological and molecular methods. S. Typhimurium was detected at 17.7% (CI: 14.2%-21.8%) in commercial poultry farms in Copperbelt Province, of which 12.8% (CI: 9.8%-16.5%) were found harboring the CTX-M-Type ESBL genes. S. Typhimurium isolates showed 88.2% resistance to at least one antimicrobial compound. All the isolates showed 100% resistance to tetracycline, followed by ampicillin and amoxicillin at 91.2%. These isolates also showed 58.8% resistance to cefotaxime and 54.4% to ceftazidime. Detection of CTX-M ESBL producing Salmonella Typhimurium suggests the contamination of chicken food chain at farm level and calls for public health protection measures.
Design of Approximate Multiplier for Error-Tolerant Applications

Field: Computer Science (Physical Sciences)

CMOS scaling has reached to the level, where process variation has become significant problem hindering further scaling. Various approaches to mitigate process variation effect try to nullify at the cost of increased area/power consumption. There are some applications which accept small errors such as multimedia processing. Designing accurate circuit for these applications is waste of area/power. This paper proposes low power, high speed approximate multiplier. The proposed multiplier outperforms and provides significant improvement in power, area, and delay at the cost of little degrade in accuracy. Experimental result shows that the proposed multipliers consume less power and require less area compared to conventional truncated multiplier.
New and Non official Remedies

Field: Medicine (Health Sciences)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown. Here we show that overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereby regulating systemic glucose homeostasis. Ectopic expression of XBP1s in adipocytes improves glucose tolerance and insulin sensitivity in both lean and obese (ob/ob) mice. The beneficial effect of adipocyte XBP1s on glucose homeostasis is associated with elevated serum levels of HMW adiponectin and indeed, is adiponectin dependent. Mechanistically, XBP1s promotes adiponectin multimerization rather than activating its transcription likely through a direct regulation of the expression of several ER-chaperones involved in adiponectin maturation, including Grp78, Pdia6, ERp44 and DsbA-L. Thus, we conclude that XBP1s is an important regulator of adiponectin multimerization, which may lead to a new therapeutic approach for the treatment of type 2 diabetes and hypoadiponectinemia.
Figure 6 from: Suzuki Y, Hisasue Y (2024) Discovery of presumably introduced spiders, Oedignatha scrobiculata Thorell, 1881 (Araneae, Liocranidae) and Boagrius qiong Lin & Li, 2022 (Araneae, Palpimanidae) on Chichi-jima Island, the Ogasawara Islands, Japan. Biodiversity Data Journal 12: e121421. https://doi.org/10.3897/BDJ.12.e121421

Field: Agricultural and Biological Sciences (Life Sciences)

Figure 6 Male of Boagrius qiong Lin & Li, 2022 from Chichi-jima Island, Japan (TKPM-AR 3219). A habitus, dorsal view; B carapace, dorsal view; C habitus, ventral view; D habitus, lateral view, left legs removed; E left leg I, prolateral view. Arrows indicate prolateral scopula of tibia and distal preening brush of metatarsus.
Reply to “Technical Notes on the Correct Configuration of the Alfred 60/AST Device for the Detection of Urinary Tract Infections”

Field: Health Professions (Health Sciences)

We thank [Dr. Spezzotti][1] for his interest in our analysis ([1][2]). Following review of the raw data provided by ourselves, Dr. Spezzotti has identified several issues that may have resulted in an underestimation of the performance of the Alfred 60/AST device.

First, Dr. Spezzotti questions the
Dissemination of Piscine orthoreovirus-1 (PRV-1) in Atlantic Salmon (Salmo salar) during the Early and Regenerating Phases of Infection

Field: Veterinary (Health Sciences)

Piscine orthoreovirus-1 (PRV-1) can cause heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar), but the line of events from infection, pathologic change, and regeneration has not been thoroughly described. In this study, the cellular localization and variation of PRV-1 RNA and protein levels were analyzed at different times post-exposure in experimentally infected Atlantic salmon. Immunohistochemistry, flow cytometry, and Western blot were used for assessment of the presence of the PRV-1 σ1 protein, while RT-qPCR and in situ hybridization were performed for viral RNA. Histopathologic evaluation demonstrated that PRV-1 infection induced heart lesions typical of HSMI, such as severe epicarditis and myocarditis with degeneration of cardiomyocytes, necrosis, and diffuse cellular infiltration. PRV-1 infection of erythrocytes and the peak viral plasma level preceded virus presence in cardiomyocytes and hepatocytes. Arginase-2-positive, macrophage-like cells observed in the heart indicated possible polarization to M2 macrophages and the onset of regenerative processes, which may contribute to the recovery from HSMI. The virus was cleared from regenerating heart tissue and from hepatocytes, but persisted in erythrocytes.
Astride two worlds

Field: Social Sciences (Social Sciences)

Abstract This paper explores the emergence of Italian-American identity and its correlation with changes in format, content, and language over the course of the first five decades of the twentieth century in La Gazzetta del Massachusetts ( The Massachusetts Gazette ), a weekly newspaper published in Boston, but intended for the Greater New England Italian community. A representative longitudinal sample of 528 equally-spaced issues between 1903 and 1949 reveals patterns that are suggestive of an evolving population and an ethnic community’s changing attitudes toward its ancestral culture and relationship with its homeland. Findings relate to prior work in the areas of the Italian immigrant language press, sociology, cultural assimilation and preservation, as well as studies of identity construction through language.
A new genus and species of Eumolpinae (Coleoptera: Chrysomelidae) from the western dry forest of Ecuador

Field: Agricultural and Biological Sciences (Life Sciences)

Flowers, Wills (2009): A new genus and species of Eumolpinae (Coleoptera: Chrysomelidae) from the western dry forest of Ecuador. Zootaxa 2132: 65-68, DOI: 10.5281/zenodo.188402
INFLATION REGIMES AND RETAIL PRICE DYNAMICS. AN EMPIRICAL STUDY FOR ARGENTINA

Field: Economics, Econometrics and Finance (Social Sciences)

This working paper analyze the dynamic behavior of retail prices in the Argentine economy during the period 1957-2017. For this purpose, a model of autoregressive vectors with structural breaks was estimated, following the methodology proposed by (Balke, 2000), based on a set of variables that impact the price formation process for the different inflationary regimes identified in the considered period. The analysis of the sensitivity of retail inflation rates to unexpected fluctuations in these variables indicates that there would be a non-linear behavior (twelve months horizon) in the transmission of the shocks recorded on the variables of the model for the three identified regimes.
Dysfunction of myocardial and vascular taurine transport in spontaneously hypertensive rats.

Field: Medicine (Health Sciences)

The alterations of taurine transport and the expression of taurine transporter (TAUT) mRNA in myocardium and aortic wall were investigated in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. It was demonstrated that plasma taurine concentration and taurine release from myocardium and aortic wall in SHR were higher than those in WKY rats, whereas taurine content, taurine uptake and TAUT mRNA in myocardium and aortic wall of SHR were lower than those of WKY rats. In SHR, the maximal velocity (V(max)) of taurine transportation in myocardium and aortic wall was lower by 24% (P<0.05) and 35% (P<0.05) than that in WKY, their michaelis constants (Km) values were higher by 16% (P<0.05) and 39% (P<0.05), respectively. The results suggest that there is dysfunction of taurine transport in myocardium and aortic wall in SHR, which may be partly resulted from the decrease of TAUT activity and affinity, and down-regulation of TAUT gene expression.
Evaluation of Khorasan Razavi’s Wheat Landraces (Triticum aestivum) Under Drought Stress and Identification of Effective Traits on Grain Yield

Field: Agricultural and Biological Sciences (Life Sciences)

Bread wheat (Triticum aestivum L) is one of the most important crops that is grown in most parts of the world in different climatic conditions. But biotic and abiotic stresses reduce the yield of this crop. Among abiotic stresses, drought stress is one of the most important factors in reducing yield in most cultivated areas of this crop. Resistant cultivar is one of the basic strategies to overcome the problems caused by drought stress. This experiment was carried out in order to identify and determine the most tolerant of native bread wheat genotypes of Khorasan Razavi province of Iran country in drought stress, in the research farm of the Department of Agronomy and Plant Breeding of the Campus of Agriculture and Natural Resources, University of Tehran in 1400-1399. In this experiment, 105 native populations with 4 controls in two environments: normal and drought stress were studied using augmented design. The traits evaluated included phenological, morphological, yield and yield components. The results showed that drought stress reduced most traits, including yield (21.87%), biological yield (24.39%), and thousand-seed weigh (8.64%). Phenotypic correlation, regression and path analysis, showed that grain filling period, biological yield, harvest index, thousand grain weight, number of grain per spike, grain weight per spike increased grain yield under drought stress. Stem weight had a negative relationship with grain yield. Cluster analysis was performed according to the ward method. The genotypes were divided into 8 groups in the normal environment and seven groups in the stress environment. The first and third groups of stress environment were introduced as tolerant and more tolerant groups respectively.