Association Between Il-1Β, Il-8, Il-10 And Vegf Polymorphisms And Risk Of Odontogenic Maxillofacial Infections

Field: Medicine (Health Sciences)

Adubetskaya A. Yu., Schneider S. A., Ulianov V. O. Association between IL-1β, IL-8, IL-10 and VEGF polymorphisms and risk of odontogenic maxillofacial infections. Journal of Education, Health and Sport. 2018;8(5):309-318. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1343634 http://ojs.ukw.edu.pl/index.php/johs/article/view/5796 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author(s) 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.04.2018. Revised: 12.04.2018. Accepted: 31.05.2018. Association between IL-1β, IL-8, IL-10 and VEGF polymorphisms and risk of odontogenic maxillofacial infections A. Yu. Adubetskaya1, S. A. Schneider1, V. O. Ulianov2 1State Establishment «The Institute of Stomatology and Maxillo-Facial Surgery of the National Academy of Medical Science of Ukraine» 2Odessa National Medical University Abstract Background. Nowadays it is being reported an increased number of cases of generalization of odontogenic infections which are caused by dental caries, periodontal diseases and other oral diseases. The beginning and progression of diseases depend on individual genetic profile of patient, but data about the role of genetic factors in purulent-inflammatory diseases of maxillofacial area pathogenesis are limited now. The aim of this study was to assess the possible association between IL-1β, IL-8, IL-10 and VEGF polymorphisms and risk of odontogenic maxillofacial infections. Materials and methods 80 patients with odontogenic maxillofacial infection (with and without diabetes mellitus) and 20 donors were examined. All patients’ with odontogenic maxillofacial infection groups were operated and received antibiotic and detoxification therapy. Polymorphism in IL-1B +3954C/T (rs1143634), IL-8 -251T/A (rs4073), IL-10 -1082G/A (rs1800896) and VEGF -634 G/C (rs 2010963) were assessed by polymerase chain reaction. Odds ratio (OR) with 95% confidence interval (CI), Chi-square test were used for statistical analyses. Results. No association observed between VEGF -634 G/C polymorphism and risk of odontogenic maxillofacial infections in patient without diabetes mellitus using all the genetic models. In patients with diabetes mellitus observed association between VEGF -634 G/C polymorphism and odontogenic maxillofacial infections in the codominant (OR=0,429, 95%СІ 0,185-0,994, р=0,046), heterozygous (OR=0,167, 95%СІ 0,048-0,574, р=0,004)and recessive (OR=0,194, 95%СІ 0,061-0,619, р=0,005) models. Polimorphism IL-1B +3954C/T increased the risk of odontogenic maxillofacial infections in patient without diabetes mellitus in the codominant (OR=0,059, 95%СІ 0,023-0,151, р<0,001), homozygous (OR=0,021, 95%СІ 0,003-0,129, р<0,001), dominant (OR=0,028, 95%СІ 0,005-0,145, р<0,001) and recessive (OR=0,0074, 95%СІ 0,019-0,291, р<0,001) models. Polimorphism IL-10 -1082 G/A increased the risk of odontogenic maxillofacial infections in the codominant (OR=0,356, 95%СІ 0,146-0,870, р=0,021), heterozygous (OR=0,106, 95%СІ 0,028-0,399, р<0,001) and recessive (OR=0,143, 95%СІ 0,043-0,472, р<0,001) models. Aassociation between IL-8-251 T/A polymorphism and risk of odontogenic maxillofacial infections it was found only codominant (OR=0,444, 95%СІ 0,198-1,0, р=0,048) genetic model. In these cases the risk of odontogenic maxillofacial infections were similar in patient without and with diabetes mellitus. Conclusion. The IL-1B (+3954C/T), IL-10 (-1082G/A) polymorphism increases odontogenic maxillofacial infections risk in patient without diabetes mellitus. The IL-1B (+3954C/T), IL-10 (-1082G/A) and VEGF (-634G/C) polymorphism increases odontogenic maxillofacial infections risk in patient with diabetes mellitus. Key words: odontogenic maxillofacial infections, IL-1B, IL-10, IL-8, VEGF, polymorphism