jimnoneill/paper-to-field-training huggingface dataset:
Topical Nano Clove/Thyme Gel against Genetically Identified Clinical Skin Isolates: In Vivo Targeting Behavioral Alteration and IGF-1/pFOXO-1/PPAR γ Cues

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Antimicrobial resistance is a dramatic global threat; however, the slow progress of new antibiotic development has impeded the identification of viable alternative strategies. Natural antioxidant-based antibacterial approaches may provide potent therapeutic abilities to effectively block resistance microbes’ pathways. While essential oils (EOs) have been reported as antimicrobial agents, its application is still limited ascribed to its low solubility and stability characters; additionally, the related biomolecular mechanisms are not fully understood. Hence, the study aimed to develop a nano-gel natural preparation with multiple molecular mechanisms that could combat bacterial resistance in an acne vulgaris model. A nano-emulgel of thyme/clove EOs (NEG8) was designed, standardized, and its antimicrobial activity was screened in vitro and in vivo against genetically identified skin bacterial clinical isolates (Pseudomonas stutzeri, Enterococcus faecium and Bacillus thuringiensis). As per our findings, NEG8 exhibited bacteriostatic and potent biofilm inhibition activities. An in vivo model was also established using the commercially available therapeutic, adapalene in contra genetically identified microorganism. Improvement in rat behavior was reported for the first time and NEG8 abated the dermal contents/protein expression of IGF-1, TGF-β/collagen, Wnt/β-catenin, JAK2/STAT-3, NE, 5-HT, and the inflammatory markers; p(Ser536) NF-κBp65, TLR-2, and IL-6. Moreover, the level of dopamine, protective anti-inflammatory cytokine, IL-10 and PPAR-γ protein were enhanced, also the skin histological structures were improved. Thus, NEG8 could be a future potential topical clinical alternate to synthetic agents, with dual merit mechanism as bacteriostatic antibiotic action and non-antibiotic microbial pathway inhibitor.
Mount Hood Earthquake Activity: Volcanic or Tectonic Origins?

Field: Earth and Planetary Sciences (Physical Sciences)

We analyze well-constrained earthquakes from the summer 2002 sequence near Mount Hood, recorded by the Pacific Northwest Seismic Network (PNSN), and well-constrained, small earthquakes (MD 3.5) recorded by the PNSN between 1986 and 2002. We apply waveform cross-correlation to selected events, establish a one-dimensional P-wave velocity model, and relocate the entire catalog by using the double-difference algorithm of Waldhauser and Ellsworth (2000). We find that earth-quakes before 2002 occur in four distinct clusters: (A) a well-defined linear feature, striking N15E, about 5 km south of the summit, (B) a linear feature, trending north-west–southeast a few kilometers south of group A, (C) a few tight clusters located about 9 km south-southwest of the summit, and (D) a small cluster beneath the summit. Earthquakes in group D do not appear to lie on a fault and may relate to volcanic activity. However, almost all earthquakes in the 2002 swarm occur in group A, south of the summit, at depths similar to earthquakes from previous swarms. First-motion fault-plane solutions from the mainshock and largest aftershocks have normal mechanisms, and solutions from well-constrained aftershocks have normal to oblique normal mechanisms. This is consistent with the apparent strike of the feature south of Mount Hood’s summit and is similar to focal mechanisms of older earthquakes in group A. b- and p-values for the summer 2002 earthquakes resemble a tectonic mainshock-aftershock sequence. We interpret these earthquakes as the northernmost example of Basin-and-Range seismicity yet recorded and conclude that the Mount Hood earthquakes do not yet suggest potential for volcanic unrest.
Exacerbation of mild lung disorders to lethal pulmonary hypoplasia by a noncoding hypomorphic SNV in a lung‐specific enhancer in trans to the frameshifting TBX4 variant

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Variants involving TBX4 are associated with a wide variety of disorders, including pulmonary arterial hypertension, ischiocoxopodopatellar syndrome (ICPPS)/small patella syndrome (SPS), lethal lung developmental disorders (LLDDs) in neonates, heart defects, and prenatally lethal posterior amelia with pelvic and pulmonary hypoplasia syndrome. The objective of our study was to elucidate the wide variable phenotypic expressivity and incomplete penetrance in a three‐generation family with a truncating variant in TBX4 . In addition to exome and genome sequencing analyses, a candidate noncoding regulatory single nucleotide variant (SNV) within the lung‐specific TBX4 enhancer was functionally tested using an in vitro luciferase reporter assay. A heterozygous frameshift variant c.1112dup (p.Pro372Serfs*14) in TBX4 was identified in patients with mild interstitial lung disease (1), bronchiolitis obliterans (1), recurrent pneumothorax (1), ICPPS/SPS (1), LLDD (2), and in unaffected individuals (4). In two deceased neonates with LLDD, we identified a noncoding SNV rs62069651‐C located in trans to the mutated TBX4 allele that reduced the TBX4 promoter activity by 63% in the reporter assay. Our findings provide a functional evidence for the recently reported model of complex compound inheritance in which both TBX4 coding and in trans noncoding hypomorphic variants in the lung‐specific enhancer of TBX4 contribute to LLDD.
Phenology determines the robustness of plant–pollinator networks

Field: Environmental Science (Physical Sciences)

Abstract Plant–pollinator systems are essential for ecosystem functioning, which calls for an understanding of the determinants of their robustness to environmental threats. Previous studies considering such robustness have focused mostly on species' connectivity properties, particularly their degree. We hypothesized that species' phenological attributes are at least as important as degree as determinants of network robustness. To test this, we combined dynamic modeling, computer simulation and analysis of data from 12 plant–pollinator networks with detailed information of topology of interactions as well as species' phenology of plant flowering and pollinator emergence. We found that phenological attributes are strong determinants of network robustness, a result consistent across the networks studied. Plant species persistence was most sensitive to increased larval mortality of pollinators that start earlier or finish later in the season. Pollinator persistence was especially sensitive to decreased visitation rates and increased larval mortality of specialists. Our findings suggest that seasonality of climatic events and anthropic impacts such as the release of pollutants is critical for the future integrity of terrestrial biodiversity.
Bearing Fault Diagnosis Based on Multiscale Lightweight Convolutional Neural Network

Field: Computer Science (Physical Sciences)

Many bearing fault diagnosis methods often struggle to balance between adequate feature extraction and lightweight property, which makes it somewhat difficult to fulfill the accuracy and efficiency required for practical applications. To address this issue, this study describes the development of a multiscale lightweight deep learning model for accurate bearing fault diagnosis. Specifically, the Gaussian pyramid method, which can create a series of images at different scales, is employed to express the Gramian angular field (GAF) matrix images generated by transforming the bearing vibration signals to avoid the common problem of insufficient feature extraction of a single-scale image. At the same time, the dependencies between feature channels are extracted using a lightweight attention mechanism utilized in deep learning, known as Efficient Channel Attention (ECA), to improve the capability of feature representation. This approach effectively improves the learning ability of bearing fault characteristics and greatly increases the accuracy of fault diagnosis. Considering the problem related to the lightweight level of the method, a Ghost module, a type of convolution neural network system, is also employed to generate more features by using fewer parameters, thereby improving the overall calculation efficiency. Here we have developed a residual module based on the Ghost module and ECA, which can be easily integrated into most bearing fault diagnosis backbone networks. Based on our experimental tests, the developed system can clearly achieve high accuracy precision of bearing fault diagnosis to fulfill the needs of practical engineering while maintaining light weight. Specifically, the test accuracy of the proposed method using two bearing fault datasets exceeds 99.4%, and the giga floating-point operations (GFLOPs) is only 1.99, which can fully meet the needs of practical engineering.
Original Article Outcomes of Total Knee Arthroplasty in Relation to Preoperative Patient-Reported and Radiographic Measures: Data From the Osteoarthritis Initiative

Field: Medicine (Health Sciences)

Introduction: Total knee arthroplasty (TKA) is the preferred surgical treatment for end-stage osteoarthritis. However, substan-tial numbers of patients still experience poor outcomes. Consequently, it is important to identify which patient characteristics are predictive of outcomes in order to guide clinical decisions. Our hypothesis is that preoperative patient-reported outcome mea-sures and radiographic measures may help to predict TKA outcomes. Methods: Using cohort data from the Osteoarthritis Initiative, we studied 172 patients who underwent TKA. For each patient, we compiled pre- and postoperative Western Ontario
Discussion on Particle Formation and Ejection of Laser Ablation for Depositing Superconducting Thin Films

Field: Physics and Astronomy (Physical Sciences)

A new model for the particle formation and ejection of laser ablation of a target for depositing high T_c superconducting thin films is presented,by which the two features,film composition close to the ablated target and particle ejection along the normal of the target (?),can be explained conveniently. The laser fluence threshold for ablation of the target,the layer (?) kness ablated by each laser shot and the recoil pressure for particle ejection normal to the target are analyzed mathematically and their expressions have been derived.Furthermore.the absorption coefficient of Y-Ba-Cu-O material to 308nm laser irradiation and the laser fluence threshold for ablation are measured and evaluated using the derived expressions.It is shown that the theoretical prediction agrees with experiment welt
Effect of Aerial part and Root Extracts from Ferulago mughlae Pe?men and Ferulago sandrasica Pe?men Quézel Growing in Turkey on Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Ferulago species have been utilised since ancient times as antihelmentic, peptic, sedative and aphrodisiac, and as the seasoning in view of their special odors.In Turkish traditional medicine, the roots from some members of this genus are utilized as aphrodisiac, so we determined to show in vitro relaxant effect of F. mughlae Peșmen and F. sandrasica Peșmen & Quézel species extracts on corpus cavernosum (CC).A totality of 20 adult male Sprague-Dawley rats (diabetic and control groups) were induced by single intraperitoneal injection of 40 mg/kg of Streptozotocin.In vitro organ bath tests were carried out on rats to evaluate isometric pressure.Tissues were stretched with phenylephrine (Phe), and relaxation responses relevant to acetylcholine (ACh, 1 mM ), sodium nitroprusside (SNP 0.1 µM ) and electrical field stimulation (EFS, frequency 20 Hz) were gained.Whole these concentration-response curves were replicated with aqueous extracts obtained from the aerial parts and roots.The extracts were active in both groups.It was found that root extracts of F. mughlae and F. sandrasica yielded 97.80% and 97.55% relaxation.Among the extracts of roots (especially roots of F. mughlae) showed the best activity.On the other hand, lyophilized aqueous extracts of aerial part (especially F. sandrasica) showed the worst activity.Based on this findings, the roots of this species deserve further in vivo assessments for their aphrodisiac potential.
Al final, se juega once contra once. El marcador al final en el discurso de los futbolistas como recurso desresponsabilizador

Field: Arts and Humanities (Social Sciences)

This paper examines the use of the expression al final by football players of the Spanish men’s national football team in press conferences. It proposes that al final carries an argumentative function of a pondering nature, meaning ‘all things considered’. This function leads to a series of contextual effects that are both epistemic and evidential, supporting the pragmatic strategy of intensifying the listener’s commitment to the truth of the statement while mitigating the speaker’s responsibility. It also serves to highlight shared knowledge – often in the form of football clichés – thereby closing off potential controversy and reinforcing affiliation with the football community.
Information Systems in Virtual Corporations: Issues for ERP Based E-business Systems

Field: Computer Science (Physical Sciences)

Virtual corporations can be viewed as a network of creative people, resources and ideas connected by interorganizational information systems and/or by on-line services. Information systems makes virtual corporations more successful, because the communication and collaboration among dispersed business partners are key to making it happen. Virtual corporations can use different information systems on different technological platforms. In the paper we will discuss the possibilities for informational support of the Cupertino between partners within virtual corporations with focus on enterprise resource planning solutions, which became more and more important.
CT-scan diagnosis of bilateral obturator hernias in a patient with chronic chylous ascites.

Field: Medicine (Health Sciences)

Bilateral obturator hernias were diagnosed in a 61-year-old woman by CT-scan examination, permitting an elective surgical repair by preperitoneal interposition of Teflon mesh. The condition developed in a patient presenting with a 15-year history of chylous ascites, occasioned by primary hypoplasia of the lymphatic system and cirrhosis of the liver.
DP-Onto: A Semantic-based Approach for Governing Digital Provider Information

Field: Computer Science (Physical Sciences)

The demand of using digital technology has increased rapidly nowadays. Hence, it is essential for the government of any country to include digital services provider data within their open government data initiative. However, due to the lack of standardized metadata for managing digital services providers, the data is often stored across multiple organizations in a redundant manner. On top of data, digital services providers across different organizations may not be able to interoperate due to data hetereogenity and lack of semantic information compatibility. In this study, we propose to apply Linked Data and Semantic web to manage digital service providers data. To do so, DP-Onto is proposed as a core ontology for governing digital provider data. DP-Onto is demonstrated in the scope of governing digital providers data of Thailand. The usage of DP-Onto in this scope, along with the method for querying digital services providers data across different organization are demonstrated and validated in this study.
Preliminary economic evaluation of biopharming in New Zealand

Field: Economics, Econometrics and Finance (Social Sciences)

From the academic literature, this report derives an economic model or framework for considering biopharming. This model is based on a cost-benefit approach to valuing changes in products and production methods. The model indicates the product dimensions that are likely to be affected by biopharming methods and how these dimensions may affect the costs and benefits of production. It also identifies the uncertainties in existing analyses. Finally, it demonstrates a method by which careful analysis of the economic costs and benefits of biopharming could proceed. Two potential products are discussed using this model: recombinant human lactoferrin (rhLF) produced in cow’s milk and low-GI potatoes.
Fruit Injury on Apples Following Nicotine Tannate Sprays*

Field: Agricultural and Biological Sciences (Life Sciences)

A peculiar type of fruit injury following the use of nicotine tannate on apples was not duplicated when three varieties of apples were sprayed with nicotine tannate four times during July and August. Observations indicate that the injury occurs when the fruit is young and relatively easily injured. Evidence points to the presence of tannic acid as being responsible for the injury and that an excess of free nicotine in the early cover sprays will reduce the amount of injury.
Abstract 3348: Pax8-PPARδ fusion protein activates β-catenin/TCF pathways

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Pax8-PPARδ Fusion Protein (PPFP) occurs in ∼35% of follicular thyroid carcinomas. Expression of PPFP in the non-transformed rat thyroid cell line PCCL3 conferred on the cells the ability to invade through matrigel and to form colonies in anchorage independent conditions. PPFP also increased the percentage of cells that have activated β-catenin/TCF. We transfected control and PPFP expressing PCCL3 thyroid cell lines with two different β-catenin/TCF-GFP reporter systems. We then sorted a population of GFP positive cells and expanded them to obtain 100% transfected cell lines. These GFP positive cells gave rise to a new heterogenous population with a stable equilibrium between GFP positive, β-catenin/TCF active cells and GFP negative, β-catenin/TCF inactive cells. PPFP expressing cell lines contained more than twice the percentage of GFP positive cells compared to control cell lines. GFP positive PPFP expressing thyroid cells were enriched for cells exhibiting the transformed phenotypes previously observed in the unsorted, untransfected cell lines. Sorted β-catenin/TCF active single cells gave rise to heterogenous clonal populations containing both β-catenin/TCF active and negative cells. Clonal populations derived from β-catenin/TCF inactive cells remained purely negative. Clonal populations derived from GFP positive cells were twice as enriched for anchorage independent colony forming cells than GFP negative clones. More strikingly, GFP positive clones were 5-10 times more invasive than negative clones, which exhibited the same invasive potential as control cells. Treatment with PPARδ full or partial agonists further increased the β-catenin/TCF population in PPFP expressing cells. Again, the effects were confined to populations containing β-catenin/TCF active cells. Co-treatment with PPARδ antagonists reversed the effects of PPARδ agonists. These data suggest that β-catenin/TCF active cells have properties of cancer stem cells and that PPFP acts on this population to expand the stem cell like fraction. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3348. doi:1538-7445.AM2012-3348
Evaluation of the Effect of Resilience and General Quality of Life on Frailty in the Elderly

Field: Health Professions (Health Sciences)

Introduction As the life expectancy at birth improved, the increase in the elderly population, one of the most vulnerable groups in society, brings about some problems. Frailty is a condition that increases the risk of progressive deterioration in physiological functioning, hypersensitivity to stress and adverse health outcomes. Frailty is quite common in older people. In frail older people, recovery from illnesses is delayed and the likelihood of sequelae is increased. If frailty is recognized early, the likelihood of disease sequelae and mortality can be reduced. Objectives This study was conducted to determine the relationship between psychological resilience and quality of life on frailty in individuals aged 65 years and older admitted to hospital. Methods The study group of this cross-sectional study consisted of 504 people who applied to an outpatient clinic at a university hospital. The Tilburg Frailty Scale, the Connor Davidson Psychological Resilience Scale Short Form and the EQ-5D-3L General Quality of Life Scale were used. The Kolmogorov-Simirnov test, the chi-square test, the Spearman correlation analysis and the multivariate logistic regression were used to analyse the data. Results 292 of the participants in the study group were men. Their ages ranged from 65 to 90 years, and the mean was 70.5±4.9 years. Scores on the Tilburg Frail Scale ranged from 0 to 14, and the mean was 6.3±2.7 points. In the study, 71.1% of participants were classified as frail. It was determined that there was a moderate negative correlation between the results of the Tilburg Frailty Scale and the results of the Connor Davidson Psychological Resilience Scale (r= -0.436) and the EQ-5D-3L VAS Scale (r=-0.608) and a strong positive correlation between the results of the EQ-5D-3L Index Scale (r=0.729)(for each p<0.001). According to multivariate logistic regression, people who did not exercise regularly were 2,33 times more frail than those who did, and people who had a health problem that required bed rest were 2,18 times more frail than those who did not. Conclusions It was found that the frailty of people aged 65 and over is at a moderate level. An improvement in psychological resilience and general quality of life as well as an improvement in general health reduces frailty. It is recommended that people aged 65 and over to be physically active and to protect from situations that may require prolonged bed rest. Disclosure of Interest None Declared
Operator front broadening in chaotic and integrable quantum chains

Field: Computer Science (Physical Sciences)

Operator spreading under unitary time evolution has attracted a lot of attention recently, as a way to probe many-body quantum chaos. While quantities such as out-of-time-ordered correlators (OTOC) do distinguish interacting from non-interacting systems, it has remained unclear to what extent they can truly diagnose chaotic {\it vs} integrable dynamics in many-body quantum systems. Here, we analyze operator spreading in generic 1D many-body quantum systems using a combination of matrix product operator (MPO) and analytical techniques, focusing on the operator {\em right-weight}. First, we show that while small bond dimension MPOs allow one to capture the exponentially-decaying tail of the operator front, in agreement with earlier results, they lead to significant quantitative and qualitative errors for the actual front -- defined by the maximum of the right-weight. We find that while the operator front broadens diffusively in both integrable and chaotic interacting spin chains, the precise shape and scaling of the height of the front in integrable systems is anomalous for all accessible times. We interpret these results using a quasiparticle picture. This provides a sharp, though rather subtle signature of many-body quantum chaos in the operator front.