jimnoneill/paper-to-field-training huggingface dataset:
Modulation of the covalent binding of aryl hydrocarbon metabolites to DNA in vitro after treatment of rats and mice with trans-stilbene oxide

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The effect of trans-stilbene oxide (TSO) induction on the microsome-catalyzed binding of polycyclic aromatic hydrocarbon metabolites to DNA was investigated using two rodent species (Sprague-Dawley rat and C57BL/6N or NMRI Swiss mouse) and 2 different binding substrates (benzo[a]anthracene). It was determined that TSO exerts 2 separate effects on polycyclic aromatic hydrocarbons - it increases the rate of oxidation at the K-region of the molecule due to its induction of specific monooxygenases, and it increases the rate of deactivation of epoxide intermediates by induction of microsomal epoxide hydrolase activity. The importance of these individual effects were determined by inducing monooxygenase activity with BP, altering region specificity and inducing epoxide hydrolase (EH) activity with TSO, assessing the combined inductive effects of TSO and BP, inhibiting EH with 1,1,1-trichloropropene oxide, or increasing its activity by the addition of pure enzyme. This study shows that these effects are similar for both substrates examined, and that the effect of TSO on the binding to DNA of highly carcinogenic bay-region diol-epoxides is multi-faceted, due to its multiple inductive effects.
Tightrope Walkers: An Ethnography of Yoga, Precariousness, and Privilege in California's Silicon Valley

Field: Social Sciences (Social Sciences)

<p>This dissertation offers an account of precarious neoliberal subjectivity by examining the suffering of the privileged as it relates to the practice of Western yoga in California's Silicon Valley. Yoga culture underlines creating connections and community. But my research, based on twenty-seven month fieldwork in an epicenter of the global high-tech economy, reveals that yoga practitioners actually seek to experience and create "space." I suggest that yoga practitioners often cultivate an interiority aimed at giving themselves room from the judgment and expectations of others. </p><p>This dissertation portrays the complicated lives of people who are more privileged than most. In so doing, this study questions the separation between "real" and "privileged" suffering; and it explores the ethical and political implications of the problems of the well-off. I suggest that the destructive aspects of neoliberal capitalism and late modernity do not hurt only the marginalized traditionally studied by anthropologists, but also--albeit in very different ways--those who supposedly benefit from them. The social scenes of modern yoga are sites of ambivalently embodied neoliberal logic, where clusters of promises and recipes for an "art of living" are critical about aspects of capitalism while enjoying its comfort. Even though the yogic ethic and politics do not adhere to the anthropological ideals of political action, Western yoga is often an ethical practice that does not simply reproduce neoliberal logic, but also shifts it slightly from within. By creating disruption of subjectivity and gaining space from old and habitual ways of being, yoga sometimes opens up a new territory of change and reflection.</p>
Platelet (hem)ITAM Signaling Mediated Cancer-Associated Venous Thrombosis

Field: Medicine (Health Sciences)

Abstract Background-Patients with cancer are at a high risk of venous thromboembolism (VTE) and underlying mechanisms are unclear. Recent studies have shown that podoplanin (PDPN) expressing highly in primary brain tumors is associated with increasingly risk of VTE by activate platelets. The C-type lectin-like receptor 2(CLEC-2) is a type II transmembrane protein expressed on the surface of platelets and PDPN is the only known endogenous ligand for it. CLEC-2 mediates platelet activation through a hem-immunoreceptor tyrosine-based activation motif ((hem)ITAM). Objective: We tested the hypothesis that the platelet (hem)ITAM signaling is involved in the development of VTE in patients with malignant tumors, and targeted inhibitors may reduce thrombosis and improve prognosis in patients with cancer. Materials and Methods-We selected two human malignant cell lines (NCI-H226 and C8161) expressing high levels of PDPN as models to study the role of the platelet (hem)ITAM signaling in cancer-associated venous thrombosis in vitro and in vivo. Results and Conclusions-Our results showed that both types of cell lines expressing PDPN triggered platelet activation via CLEC-2 in vitro, which could be abrogated by an anti-PDPN antibody SZ-168 or syk inhibitor R406. Further, in vivo study showed that injection of NCI-H226 or C8161 in two mouse models of venous thrombosis activated platelets, increased platelet counts and enhanced thrombosis. These results suggested that platelet activation induced by PDPN was correlated with hypercoagulability, contributed to thrombosis in cancer patients. Importantly, PDPN enhanced thrombosis was reduced in mice treated with SZ168 or R406. Immunohistochemical staining using anti-PDPN antibody was also performed in pulmonary squamous cell carcinoma specimens of 166 patients. During up to 4-year-follow-up, 20 (12.05%) patients developed VTE. 105 tumor specimens stained positive for PDPN (27 high expression, 43 medium expression, 35 low expression). High PDPN expression was associated with an increased risk of VTE and poor prognosis, independently of age, sex and tumor type. In this study, we found that PDPN expression in tumors induced platelet aggregation and was associated with a high risk of VTE via platelet (hem)ITAM signaling. Our data also suggested that SZ168 inhibited PDPN-induced platelet aggregation in vitro and decreased the incidence of VTE in mice. In conclusion, our research demonstrated novel insights into the pathogenesis of cancer-associated venous thrombosis. Disclosures No relevant conflicts of interest to declare.
Chengyu info-graphic.

Field: Arts and Humanities (Social Sciences)

The first part of my research ,I focus on gathering the Chengyu and mapping them into various categories. The second part is using the data, I gather and put them into diagram and connect them together. The visualizations are part of an extensive study of the Chengyu. Many of the diagrams and charts are based on secondary sources, including but not limited to dictionary,internet source and article.
Electrophysiological and neuromuscular stability of persons with chronic inflammatory demyelinating polyneuropathy

Field: Neuroscience (Life Sciences)

ABSTRACT Introduction We assessed motor unit (MU) properties and neuromuscular stability in the tibialis anterior (TA) of chronic inflammatory demyelinating polyneuropathy (CIDP) patients using decomposition‐based quantitative electromyography. Methods Dorsiflexion strength was assessed, and surface and concentric needle electromyography were sampled from the TA. Estimates of MU numbers were derived using decomposition‐based quantitative electromyography and spike‐triggered averaging. Neuromuscular transmission stability was assessed from concentric needle‐detected MU potentials. Results CIDP patients had 43% lower compound muscle action potential amplitude than controls, and despite near‐maximum voluntary activation, were 37% weaker. CIDP had 27% fewer functioning MUs in the TA, and had 90% and 44% higher jiggle and jitter values, respectively compared with controls. Conclusions CIDP had lower strength and compound muscle action potential values, moderately fewer numbers of MUs, and significant neuromuscular instability compared with controls. Thus, in addition to muscle atrophy, voluntary weakness is also due to limitations of peripheral neural transmission consistent with demyelination. Muscle Nerve 56 : 413–420, 2017
The Figure of Captivity: The Cultural Work of the Puritan Captivity Narrative

Field: Arts and Humanities (Social Sciences)

The Figure of Captivity: The Cultural Work of the Puritan Captivity Narrative Tara Fitzpatrick Tara Fitzpatrick Search for other works by this author on: Oxford Academic Google Scholar American Literary History, Volume 3, Issue 1, Spring 1991, Pages 1–26, https://doi.org/10.1093/alh/3.1.1 Published: 01 March 1991
Design and Construction of a Test Rig for Assessing Tyre Characteristics at Rollover

Field: Engineering (Physical Sciences)

<div class="htmlview paragraph">The paper presents a new test rig (named RuotaVia) composed basically by a drum (2,6 m diameter), providing a running contact surface for vehicle wheels. A number of measurements on either full vehicles or vehicle sub-systems (single suspension system or single tyre) can be performed. Tire characteristics influencing rollover can be assessed. The steady-state maximum loads are as follows: Radial: 100kN, tangential: 100kN, lateral (axial with respect to the drum): 100kN. The superstructure carrying a measuring hub can excite the wheel under test up to 20 Hz in lateral and vertical directions. The steer angle range is ± 25 deg, the camber range is ± 80 deg. The minimum eigenfrequency of the drum is higher than 90 Hz and its maximum tangential speed is 440 km/h.</div>
Couples under One Roof: A Quantitative Analysis on Cohabitation and Relationship Dynamics

Field: Social Sciences (Social Sciences)

Cohabitation, defined as two individuals living together without marriage, is increasingly prevalent, particularly in the Philippines. This study employs a quantitative research methodology to analyze the relationship dynamics of cohabiting couples in General Santos City. Utilizing a descriptive correlation design, data were collected from 60 randomly selected cohabiting couples through adapted survey questionnaires. The study explores how cohabitation impacts relationship satisfaction and stability, addressing questions regarding various cohabitation statuses and their influence on relationship dynamics. Results indicate that cohabiting couples report high satisfaction levels, with an aggregated mean score of 3.58, suggesting that their experiences are comparable to those of married couples. Furthermore, a significant positive correlation (r = 0.323**) was found between cohabitation status and relationship dynamics (p = 0.000), indicating that while cohabitation is not the sole determinant of relationship quality, it significantly shapes couple interactions and support mechanisms. The findings align with existing literature highlighting the dual nature of cohabitation; while it can enhance intimacy and shared experiences, it also introduces challenges related to commitment and shared responsibilities. The study concludes that understanding the complexities of cohabitation is essential for promoting relationship stability among couples. Recommendations for future research include exploring factors contributing to initial satisfaction levels and developing community support programs tailored for cohabiting couples to enhance their long-term relationship quality.
A solitary bone metastasis from renal cell carcinoma

Field: Medicine (Health Sciences)

We report on an unusual case of a 59‐year‐old man with renal cell carcinoma (RCC), who presented with a pathological fracture in his left third metacarpal resulting from a single osteolytic metastasis. Nuclear bone and computed tomography scans revealed no other sites of recurrence. Zoledronic acid and palliative radiotherapy were administered, and orthopaedic follow‐up revealed healing of the lesion. The prevalence and management of bone metastases in patients with RCC are discussed.
An implementation of voice message connection control for PSTN subscribers in ATM switching system

Field: Engineering (Physical Sciences)

The IWF (inter working function) interworking between asynchronous transfer mode (ATM) and existing synchronous transfer mode (STM) network should ensure the continued support of services and applications currently provided. As the ATM switching system accommodates an STM switch, in order to give the same quality of voice services to the telephone users, the interworking system should cover various technical issues such as voice quality, echo control, partially filled cell, ATM adaptation layer (AAL) for voice, tones and announcements. The voice message connection control, which is the subject of this paper, is one of the essential technical issues for voice services. We present the design and implementation of voice message connection control technology which is used to announce the causes of call failure in the ATM switching system accommodating the public switched telephone network (PSTN) and narrowband ISDN (N-ISDN) subscribers.
Histone H4 Modification During Mouse Spermatogenesis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The core histone is composed of four proteins (H2A, H2B, H3 and H4). Investigation of the modification patterns of histones is critical to understanding their roles in biological processes. Although histone modification is observed in multiple cells and tissues, little is known about its function in spermatogenesis. We focused on the modification patterns of histone H4 during murine spermatogenesis. We demonstrated that the individual N-terminal sites of H4 show different modification patterns during the differentiation of male germ cells. The methylation pattern varied depending on the residues that were mono-, di-, or tri-methylated. All the H4 modifications were high during the meiotic prophase, suggesting that histone H4 modification plays an important role during this stage of spermatogenesis. Elongating spermatids showed increased acetylation of histone H4, which may be associated with a histone-to-protamine substitution. Our results provide further insight into the specific relationship between histone H4 modification and gene expression during spermatogenesis, which could help to elucidate the epigenetic disorders underlying male infertility.
Learning to Teach Music in the Secondary School: A Companion to School Experience (3rd Edition)

Field: Arts and Humanities (Social Sciences)

This 3rd edition of 'Learning to Teach Music in the Secondary School' has been thoroughly revised to take account of the latest initiatives, research and scholarship in the field of music education, and the most recent changes to the curriculum. By focusing on overarching principles, it aims to develop reflective practitioners who will creatively and critically examine their own and others’ ideas about music education, and the ways in which children learn music.

Providing an overview of contemporary issues in music teaching and learning from a range of perspectives, the book focuses on teaching music musically, and enables the reader to:

- place music education in its historical and social context

- consider the nature of musical knowledge and how teachers can facilitate their students to learn musically

- critically analyse the frameworks within which music teachers work

- develop an understanding of composing, performing and responding to music, as well as key issues such as creativity, individual needs and assessment

- examine aspects of music beyond the classroom and how effective links can be made between curriculum music and music outside of school.

Including a range of case studies, tasks and reflections to help student teachers integrate the theory and practice of music education effectively, this new edition will provide invaluable support, guidance and challenges for teachers at all stages of their careers, as well as being a useful resource for teacher educators in a wide range of settings.
534. The cells in bovine milk

Field: Veterinary (Health Sciences)

Using a differential staining technique, total and differential cell counts were carried out on over 5000 milk samples. It was found that the cells in both normal and abnormal milk fell into three groups: (1) Granular leucocytes, including polymorphs, eosinophils and probably basophils. (2) Lymphocytes. (3) Epithelial cells (vacuolated and non-vacuolated). The findings of some earlier workers are discussed.
Pyridine nucleotide synthesis by rat adipose tissue in vitro

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The synthesis of NAD and NADP by rat adipose tissue was measured in vitro. Nicotinamide-7-(14)C and NaH(2)(32)PO(4) were incorporated together into NAD with a (32)P/(14)C ratio of 1.82 and nicotinic-7-(14)C acid and NaH(2)(32)PO(4) with a ratio of 1.94. Nicotinic acid stimulated, by 90%, lipogenesis from glucose-U-(14)C by rat adipose tissue in vitro. Glucose plus insulin and refeeding for 48 hr after a 48 hr fast markedly increased the incorporation of nicotinic-7-(14)C into NAD in rat epididymal fat pads in vitro, but neither fructose, L-glutamine, nor insulin alone increased the synthesis of NAD in this tissue. Glucose-1-(14)C, ribose-1-(14)C, and to a greater extent glucose-6-(14)C are incorporated into the NAD of rat adipose tissue. Fasting followed by refeeding sharply increased the radioactivity of NAD-(14)C formed from glucose-1-(14)C and glucose-6-(14)C but not from ribose-1-(14)C. Increasing the ribose concentration from 2 mM to 10 mM increased its incorporation into adipose tissue NAD twofold. The nicotinic-7-(14)C acid incorporation into NAD increased over the 1st hr of incubation and remained constant for the next 3 hr. The concentration of NAD in the fat pads showed a similar response to the time of incubation. NADP concentrations increased over the entire 4 hr incubation period as did the incorporation of nicotinic-7-(14)C acid into NADP. The results of this study suggest that NAD is synthesized de novo by rat adipose tissue in vitro and that this synthesis is increased by factors which stimulate lipogenesis.
LHD lhdcxs9b-sif #139351.1

Field: Physics and Astronomy (Physical Sciences)

Charge eXchange Spectroscopy (CXS) system, which consists of diagnostic beam, object lens, optical fiber bundle array, spectrometer, CCD detector and controllers, to measure radial profiles of ion temperature, poloidal/toroidal plasma rotation velocities, and impurity density (carbon or helium) using charge exchange collisions between neutral beam and impurities.
Postanarchism and space: Revolutionary fantasies and autonomous zones

Field: Social Sciences (Social Sciences)

In this paper, I call for a re-consideration of anarchism and its alternative ways of conceptualising spaces for radical politics. Here I apply a Lacanian analysis of the social imaginary to explore the utopian fantasies and desires that underpin social spaces, discourses and practices – including planning, and revolutionary politics. I will go on to develop – via Castoriadis and others – a distinctly post-anarchist conception of political space based around the project of autonomy and the re-situation of the political space outside the state. This will have direct consequences for an alternative conception of planning practice and theory.
16 RSA security implementation in quantum computing for a higher resilience

Field: Computer Science (Physical Sciences)

The public key cryptosystem is widely used in the current scenario. The possibility of breaking this system by a quantum algorithm would pose a significant threat to the confidentiality of the data and assets held by all participants in the digital economy. This is because the public key cryptosystem was designed specifically for the purpose of encrypting information. The chapter discusses the security implementation in quantum computing using RSA to improve the security against vulnerabilities. The RSA is designed in such a way that it mitigates all possible attacks in the system, and provides better resilience against attacks. The results shows reduced computational time in detecting attacks and mitigating them than with other methods.
Attitudes toward breastfeeding working mothers.

Field: Social Sciences (Social Sciences)

This investigation assesses attitudes towards breastfeeding working mothers, employees' knowledge of their legal rights and employees' views of the new amendment of Law 427 in Puerto Rico. The sample consists of 36 men and 64 women (N = 101) employed in different institutions of the San Juan metropolitan area. Participants completed the Attitude Scale toward working breastfeeding mothers. The scale's consistency is substantiated by an item-total reliability coefficient yielding r (92) = .70, p < .05. Results show that employed Puerto Ricans may support breastfeeding working mothers. However, many individuals are not aware of the laws that protect a breastfeeding working mother and how extracting milk may help productivity instead of impairing it.
Neutrosophic kernel regression and its application

Field: Mathematics (Physical Sciences)

The main purpose of utilizing neutrosophic statistics is to analyze data when there is uncertainty in the observations. The neutrosophic kernel regression is proposed in this paper for studying the relationship between the response variable and the study variable when the data is in neutrosophic numbers. The relationship between neutrosophic dietary fat level and neutrosophic death rate from prostate cancer has been studied using neutrosophic kernel regression.
Performance Comparison of PI and P Compensation in DSP-Based Average-Current-Controlled Three-Phase Six-Switch Boost PFC Rectifier

Field: Engineering (Physical Sciences)

In this paper, it is shown that in the three-phase six-switch boost power factor correction rectifier with average-current control with mismatched input-voltage and input-current sensing gains as well as offset errors in input-voltage and input-current sensing, the current controller with proportional (P) compensation exhibits lower total harmonic distortion (THD) and higher power factor compared with that of proportional and integral compensation. It is also shown that P compensation with input-voltage feedforward is effective in improving output-voltage transient response with respect to input-voltage changes only if duty-cycle feedforward is also implemented. Finally, it is shown that zero-sequence-signal injection, in addition to enabling the output-voltage regulation in a wider input-voltage range, also improves the THD of the input currents.
Mechanism of Repression by the Sequence-Specific mRNA-Binding Protein Vts1p

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Vts1p is a member of the Smaug family of sequence-specific RNA binding proteins that interact with stem-loop sequences to degrade and/or translationally repress target transcripts. To identify the molecular mechanism by which Vts1p represses target transcripts, I have investigated the role of one of Vts1p’s conserved domains, the SSR1 domain, in Vts1p-mediated repression. In vitro SSR1 functions as a dimerization domain and I provide evidence that SSR1 mediates dimerization in vivo. I have created Vts1p mutants which abolish dimerization and found that dimerization is required for full Vts1p-mediated repression and robust destabilization of a reporter containing two SREs. My data supports a model whereby dimerization of Vts1p functions to enhance binding of Vts1p to a target transcript carrying two or more SREs. Analysis of putative Vts1p mRNA targets suggests that dimerization may be important for proper repression of many target transcripts since a majority contain multiple SREs. \nI have also shown that Vts1p interacts with the Ccr4p/Pop2p/Not deadenylase in an RNA independent fashion. This is consistent with the model that Vts1p recruits the Ccr4p/Pop2p/Not deadenylase to target transcripts to induce deadenylation and subsequent degradation. \nFinally, by tethering Vts1p to a reporter construct, I have shown that two separate regions of Vts1p, the N-terminus and the C-terminus, are sufficient for repression, suggesting that Vts1p employs multiple mechanisms to regulate the expression of target mRNAs. I have also shown that the N-terminus contains a conserved motif that functions in Vts1p-mediated translational repression while playing no role in transcript decay. This is the first evidence that Vts1p mediates the translational repression of a target transcript.