jimnoneill/paper-to-field-training huggingface dataset:
Study of the antiepileptic drugs transport through the immature blood-brain barrier

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Resistance to Antiepileptic Drugs (AEDs) has been a major concern in infantile epilepsies such as for example the Dravet Syndrome. One hypothesis concerning the pharmacoresistance in epilepsy is that a decreased delivery of these drugs to the brain may occur in relation to changes in the Blood-Brain Barrier (BBB) function. BBB exhibits ATP-binding cassette (ABC) and SoLute Carrier (SLC) transporters at the surface of endothelial cells that control the blood-brain transport. Pharmacoresistance in epilepsy may be linked to changes in the functions of these transporters since some AEDs are substrates of the P-glycoprotein (P-gP) and Breast Cancer Resistance Protein (BCRP) transporters. The increased expression of efflux transporters in epileptogenic tissue and the identification of polymorphisms in the efflux transporters genes of resistant patients further support this potential relationship. The interaction of endothelial cells with astrocytes and neurons during brain development could change the pattern of transporters in the BBB. AEDs are also known as either inducers or inhibitors of drug metabolic enzymes and membrane transporters. Taken together, these facts led us to test the following hypothesis: 1) the developing BBB in immature animals presents a different pattern of transporters that could change AEDs disposition in the brain of immature subjects; and 2) the chronic pharmacotherapy used in infantile epilepsies such as the Dravet Syndrome may change the transporters phenotype of the BBB. Our work showed that the expression of P-gP and BCRP increases during development as a function of age. We also showed the maturation of the BBB has an impact on brain disposition of the studied AEDs. We finally observed an increase in the expression of various ABC and SLC transporters induced by the pharmacotherapy of the Dravet Syndrome in immature animals. One of the drugs used, valproic acid, appeared nonetheless to reduce the efflux activity of P-gP in developing and adult animals, which was confirmed in an in-vitro model of the immature BBB. Taken together, these results demonstrated that the interaction between the developing BBB and the AEDs chronic treatment may lead to differences in brain disposition of the AEDs that may impact on the response to AEDs.
Comparative study of isolating c-kit-positive hepatoma carcinoma cells with flow cytometry sorting, magnetic cell sorting and immune panning isolation

Field: Medicine (Health Sciences)

目的 比较流式细胞仪、免疫磁珠及亲和板结合分离法分选肝癌亚群细胞的效果.方法 原代培养肝细胞癌细胞,分别以流式细胞仪、免疫磁珠及亲和板结合分离法分选c-kit+肝癌细胞,然后使用流式细胞仪鉴定细胞纯度,计算回收率;以台盼蓝检测细胞活力,CCK-8法检测细胞增殖能力,裸鼠移植测其成瘤率,并进行统计学分析.结果 流式细胞仪分选所得到的c-kit+肝癌细胞纯度、回收率最高,与其他两种方法分选所得细胞的相应指标比较,差异有统计学意义(P＜0.05);3种方法所得细胞之间的细胞活力、刺激指数、移植成瘤率比较,差异无统计学意义(P＞0.05).流式细胞仪分选前后的细胞之间活力、刺激指数比较,差异无统计学意义(P＞0.05).结论 流式细胞仪分离法是分离肝癌亚群细胞的较佳方法。
Positron Emission Tomography

Field: Physics and Astronomy (Physical Sciences)

This chapter describes the physics of positron emission tomography (PET) together with a short overview of data quantification and reconstruction and data analysis and interpretation. A PET scanner is designed to provide a measurement of the spatial distribution of a PET radiotracer within a subject. PET utilizes radiotracers labeled with positron-emitting radionuclides designed to selectively target specific processes or sites of interest. A valid PET event is comprised of the detection of the two annihilation photons within a temporal interval by two different, opposing detectors. The definition of detector pairs that can accept a coincident event defines the imaging field of view. Modern small animal PET scanners have detectors that provide sufficiently high spatial resolution for the positron range–derived image degradation to be noticeable. An important characteristic of PET is its potential to provide quantitative data, that is, to provide a measure of counts that is proportional to the underlying radioactivity concentration anywhere in the object.
A Framework for Bilingual School Consultation to Facilitate Multitier Systems of Support for English Language Learners

Field: Social Sciences (Social Sciences)

Bilingual students comprise a substantial and growing proportion of U.S. school enrollment and often experience unsatisfactory school outcomes attributed to limited opportunities to learn. Bilingual consultants have the unique opportunity to shape school psychological services and general education supports for all bilingual students by working with monolingual professionals and stakeholders to improve the instructional and mental health services provided to bilingual students, particularly English language learners. In this article, we provide a framework for integrated individual and systemic bilingual school consultation that extends existing consultation models. Specifically, we (a) compare the proposed framework to existing consultation models, (b) identify core competencies for bilingual consultants, (c) describe how the bilingual consultant can contribute to multitier systems of support responsive to the needs of all students, and (d) offer a case study of implementation of the framework. Implications for professional development and research are addressed.
The Compliant Joint Toolbox for MATLAB: An Introduction With Examples

Field: Computer Science (Physical Sciences)

This article presents the Complianhis Compliant Joint Toolbox for the modeling, simu lation, and controller development of compliant robot actuators. The object-oriented toolbox is written in MATLAB/Simulink. In a few lines of code, it can batch-generate ready-to-use joint actuator model classes from multiple parameter sets, in corporating a variety of nonlinear dynamics effects.
Leo Lewie double murder, 1957

Field: Arts and Humanities (Social Sciences)

2 images. Leo Lewie double murder, 19 July, 1957. Leo Lewie (suspect); Attorney Adolph Alexander.; Caption slip reads: "Photographer: Snow. Date: 1957-07-19. Reporter: Sid Bernstein. Assignment: Leo Lewie, double murder suspect, at Beverly Hills city jail. Left to Right: Lewie and his attorney, Adolph Alexander, confer before arraignment in Beverly Hills Municipal Court."
TheMenologiumandMaxims IIin the Manuscript Context

Field: Arts and Humanities (Social Sciences)

Journal Article The Menologium and Maxims II in the Manuscript Context Get access Kazutomo Karasawa Kazutomo Karasawa Komazawa University Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 62, Issue 3, September 2015, Pages 353–356, https://doi.org/10.1093/notesj/gjv114 Published: 08 July 2015
THE QUALITY OF MEDICAL CARE IN MEDICAL ORGANIZATIONS OF MOSCOW PUBLIC HEALTH CARE SYSTEM IN APPRAISALS OF PATIENTS AND PHYSICIANS

Field: Health Professions (Health Sciences)

The article presents the analysis of results of complex medical sociological survey of effectiveness and efficiency of medical care as main criteria of its quality and accessibility. The survey comprised 1,737 patients of various social groups of population of Moscow and 203 physicians of polyclinics. At self-rating of health, 13.2% of respondents determined it as unsatisfactory, 45.1% as satisfactory and 31.3% as good. In all population groups, the most called-for proved to be polyclinic institutions. The high level of satisfaction of patients with quality of emergency medical care was established in all groups. The quality of medical care in polyclinics and hospitals was assessed significantly lower. The most negatively assessed criteria turned out transition to fee-for-service forms of medical support and time limits of waiting for all modes of medical care, except emergency medical care and district therapist. The evaluation by physicians of their own activity and present problems is characterized by their unanimity in need of increasing of salary (100%) and increasing of typical sectoral standards of time of reception of a patient (96.5%), decreasing of intensity of work of medical personal (92.3%) and reduction of some forms of record cards with the purpose of releasing of time and attention of physician for a patient (88.4%). The disrespectful attitude of patients to medical personnel was mentioned by 77.3% of physicians which is a new phenomenon testifying loss of confidence in patient-physician relationship. The quality of implemented work was assessed equally and rather high by both young and experienced physicians. The positive and negative aspects of reorganization of health care were analyzed. Two alternatives of problems were established to focus plans of development of system of Moscow health care to support accessible and qualitative medical care of population.
<title>Influence of acoustic power on parietal thermometry during extracorporeal high-intensity focused ultrasound treatments</title>

Field: Medicine (Health Sciences)

Objectives: Compare the muscular parietal heating during high intensity focused ultrasound (HIFU) at different acoustic power levels. Methods: 3 series of 100 acoustic pulses of same energy but variable power were applied in vivo on the muscular lumbar and abdominal walls in 4 pigs. The target volume was located 47 to 94 mm behind the skin. Two thermocouples were inserted into the muscular wall facing the focal point 10 - 15 m and 25 - 30 mm from the skin. The position of the treatment head was the same for the 3 series of acoustic pulses. The temperatures in the muscular wall were recorded during the HIFU treatment. Conclusion: During extracorporeal HIFU treatments, the muscular parietal heating is variable among individuals and increases with the acoustic power.
Value of Endoscopic Ultrasonography in the Management of Portal Hypertension

Field: Medicine (Health Sciences)

Using endoscopic ultrasonography (EUS) a large part of the portal venous system can be visualized. In 40 patients with portal hypertension (PH) and in 48 control subjects EUS displayed the azygos, splenic, mesenteric and portal veins in both groups. However, esophageal and gastric varices, peri- esophageal and peri-gastric collateral veins and submucosal gastric venules were displayed only in patients with PH. EUS was inferior to endoscopy for detecting and grading esophageal varices (p less than 0.0005), but superior in the detection of varices in the fundus of the stomach (p less than 0.0005). EUS cannot be considered a reliable method for the study of esophageal varices: it has an overall sensitivity of 50%, does not permit flow measurements, and does not provide information that could be used to estimate the risk of bleeding. EUS has been demonstrated to be superior to endoscopy in the diagnosis of gastric varices. This finding is extremely important for the optimal selection of treatment of patients with portal hypertension. EUS can detect portal hypertensive gastropathy; thus inflammatory gastritis can be more easily distinguished from congestive gastropathy and therapeutic decisions are strongly influenced.
Molecular orbitals for general polyatomic molecules. I

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular orbitals for general polyatomic molecules. ILouis C. Cusachs and Barbara B. CusachsCite this: J. Phys. Chem. 1967, 71, 4, 1060–1073Publication Date (Print):March 1, 1967Publication History Published online1 May 2002Published inissue 1 March 1967https://pubs.acs.org/doi/10.1021/j100863a043https://doi.org/10.1021/j100863a043research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Prior-free 3D tracking of a fast-moving object at 6667 frames per second with single-pixel detectors

Field: Computer Science (Physical Sciences)

Real-time tracking and 3D trajectory computation of fast-moving objects is a promising technology, especially in the field of autonomous driving. However, existing image-based tracking methods face significant challenges when it comes to real-time tracking, primarily due to the limitation of storage space and computational resources. Here, we propose a novel approach that enables real-time 3D tracking of a fast-moving object without any prior motion information and at a very low computational cost. To enable 3D coordinate synthesis with a space-efficient optical setup, geometric moment patterns are projected on two non-orthogonal planes with a spatial resolution of 125 μm. Our experiment demonstrates an impressive tracking speed of 6667 frames per second (FPS) with a 20 kHz digital micromirror device (DMD), which is more than 200 times faster than the widely adopted video-based tracking methods. To the best of our knowledge, this is the highest tracking speed record in the field of single-pixel 3D trajectory tracking. This method promotes the development of real-time tracking techniques with single-pixel imaging (SPI).
EFFECTS OF GLUCAGON ON PANCREATIC SECRETION IN THE DOG

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

1. The effects of glucagon on the secretion of pancreatic juice were investigated using blood-perfused canine pancreas preparations. 2. Intravenous administration of glucagon (3-30 mug/kg) to the donor dog elicited a dose-dependent increase in pancreatic secretion. Intra-arterial administration of glucagon (10-100 mug) into the perfused pancreas also elicited increased secretion. 3. There were slight increases in amylase concentration of the pancreatic juice with the largest doses of glucagon given by either route. 4. Glucagon-induced secretion was not modified by treatment with phentolamine, propranolol, atropine, guanethidine, tetradotoxin, haloperidol, prostaglandin F2alpha or calcitonin. 5. The results suggest that glucagon acts directly on the exocrine cells of the canine pancreas.
PENGARUH PROMOSI MEDIA SOSIAL, KUALITAS PELAYANAN DAN LAYANAN COD TERHADAP KEPUTUSAN PEMBELIAN MELALUI MINAT BELI SEBAGAI VARIABEL INTERVENING PADA UD AFITA HANDCRAFT DI BONDOWOSO

Field: Business, Management and Accounting (Social Sciences)

This study aims to analyze the influence of social media promotion, service quality, and COD services on purchasing decisions through purchase interest as an intervening variable at UD Afita Handcraft in Bondowoso. The research method used a quantitative approach with simple random sampling techniques on 83 respondents. The data were analyzed using Partial Least Square (PLS) through the Smart PLS 3.0 application. The results indicate that social media promotion has a positive but insignificant effect on purchase intention, while service quality and COD services have a significant positive effect. Meanwhile, service quality is proven to have a significant effect on purchasing decisions, but social media promotion and COD services do not show a significant effect. Purchase intention as an intervening variable is also proven to have a significant effect on purchasing decisions. Specifically, COD services have a significant influence on purchasing decisions through purchase interest, while social media promotions and service quality are not significant in this relationship. The implications of this study suggest that UD Afita Handcraft should focus more on improving service quality and optimizing COD services to strengthen consumer purchase interest and purchasing decisions. In addition, social media promotion strategies need to be improved to be more effective in attracting purchase interest.
Effect of salinity, alkalinity, phosphate and organic matter on the movement of nematicides in soil

Field: Environmental Science (Physical Sciences)

There are many problems associated with the application of pesticides in the soil, as reviewed by Bailey and White (1970). Singh et al. (1977) found that several factors such as organic matter, calcium carbonate and pH of the soil influenced the movement of nematicides. No attempt has so far been made to determine the effect of different salts, normally present in the soil, on the mobility of nematicides. The present study examines the effect of different saline, alkaline, phosphatic and neutral salts on the movement of dazomet, ox amyl and dichlorofenthion in the soil.
David Harrison: a career in the anthropology of tourism and the sociology of development

Field: Social Sciences (Social Sciences)

This paper analyses the career of the sociologist/social anthropologist of tourism David Harrison. An important figure in tourism studies across disciplinary boundaries and regional specialisation, Harrison went from academic appointments in Britain to the University of the South Pacific in Fiji and back to Britain again, conducting field studies in the Caribbean, Africa, Europe, and Asia and the Pacific. He engaged in and anticipated theoretical debates in the anthropology of tourism and the sociology of development, publishing key books, articles, and book chapters. In this paper, Harrison discusses the main theoretical position he came to take up. This entailed a political economy position that simultaneously considered the interaction of world economic and political systems with local systems of behaviour and meaning, yet based on empirical first-hand research, all with a kind of fundamental skepticism of foregone conclusions offered by pre-approved orthodox theories. The paper provides detailed information on Harrison's early life and unconventional path to the profession, his theoretical influences and directions, and his career trajectory.
Large scale proteomics of circulating extracellular vesicles to reveal novel biomarkers for pancreatic cancer.

Field: Medicine (Health Sciences)

523 Background: Robust biomarkers are urgently needed to assist in diagnosing pancreatic cancer. Earlier cancer diagnosis could increase survival rates by an estimated 5-fold and more reliable and real-time assessment of treatment effects in patients with cancer could improve quality of life and reduce healthcare costs. Isolation of circulating extracellular vesicles (cEVs) as ‘liquid biopsies’ offers an advantageous approach to diagnose and monitor disease status. Methods: We conducted a comprehensive proteomics study of cEVs from plasma samples to identify EV proteins that may be used as biomarkers for the diagnosis and prognosis of pancreatic cancer. Patients with pancreatic ductal adenocarcinoma (PDAC) of various tumor stages, chronic pancreatitis, intraductal papillary mucinous neoplasm (IPMN), and age-matched controls were enrolled. EVs were isolated directly from plasma samples using the affinity-based EVTrap method then subject to quantitation by liquid chromatography-tandem mass spectrometry. Results: A total of 124 patients (93 with PDAC, 12 with chronic pancreatitis, 8 with IPMN and 11 controls) were included in the discovery cohort. The isolation of EVs with EVtrap allowed the identification on average of 912 EV proteins per 100µL of sample. Principal component analysis of the cEV proteome showed clear separation between PDAC and benign pancreatic diseases. Individuals with IPMN were more closely related to controls, whereas chronic pancreatitis cases were more related to PDAC. At the functional level, we noted that cytokeratin, protein folding chaperons, and actin dynamics regulators were among protein clusters more highly altered in the cEV of patients with PDAC. We further identified new cEV markers associated with metastatic disease, such as PSMB4, RUVBL2, and ANKAR, as well as other EV proteins with strong correlation to prognosis, such as CRP, RALB, and CD55. Finally, we validated a 7-protein PDAC EV signature in a validation cohort of 36 separate patients (24 with PDAC, 6 with chronic pancreatitis and 6 with IPMN) which yielded an 89% prediction accuracy for the diagnosis of PDAC. Conclusions: This study provides a valuable resource to the scientific community with a comprehensive catalog of novel proteins on circulating EVs that may assist in the development of novel biomarkers and improve the outcomes of patients with pancreatic cancer.
Hash Based Encryption for Keyframes of Diagnostic Hysteroscopy

Field: Computer Science (Physical Sciences)

In this paper, we address the problem of confidentiality of keyframes, which are extracted from diagnostic hysteroscopy data using video summarization. We propose an image color coding method aimed at increasing the security of keyframes extracted from diagnostic hysteroscopy videos. In this regard, we use a 2-D logistic map to generate the cryptographic keys sequences, which relies on mixing and cascading the orbits of the chaotic map in order to generate the stream keys for the encryption algorithm. The encrypted images produced by our proposed algorithm exhibit randomness behavior, providing a high-level of security for the keyframes against various attacks. The experimental results and security analysis from different perspectives verify the superior security and high efficiency of our proposed encryption scheme compared to other state-of-the-art image encryption algorithms. Furthermore, the proposed method can be combined with mobile-cloud environments and can be generalized to ensure the security of cloud contents as well as important data during transmission.
Forming and maintaining a collection of plant genetic resources of the Buckwheat (Fagopyrum Mill.) genus

Field: Agricultural and Biological Sciences (Life Sciences)

Purpose. Providing information on the formation, composition, maintenance of the collection of Buckwheat (Fagopyrum Mill.) genus at Ustymivka Experimental Station of Plant Production (Poltava region), and areas of its use: introduction, preservation and study of the material, for the set of index, formation of special collections and providing research and education institutions of Ukraine with a valuable original material. Methods. Methodical developments dealing with formation and maintenance of crop collections, methodical literature on the study of buckwheat collection for breeding and agronomic performance. Results. The author represented results of the collection material study for the main breeding and economically valuable traits including yield, productivity, resistance to abiotic and biotic factors of the environment. The results of work are considered aimed on creating special collections of the gene pool – base, trait (for yield and large seeds; for productivity, drought and heat resistance; for suitability for mechanical cultivation), educational and core ones. Conclusions. All formed and registered collections are a valuable base material for solving a number of breeding goals to increase the quantity and improve the quality of plant production.