jimnoneill/paper-to-field-training huggingface dataset:
Gene expression in leaves ofArabidopsis thalianainduced to senesce by nutrient deprivation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Senescence was induced in leaves of Arabidopsis thaliana by transferring rosettes from a nutrient-sufficient medium to water. A visible gradient of yellowing along the shoot axis became apparent within 5 d. Leaves were grouped into four age-classes, representing fully green (nodes 17–20) through about one-third (nodes 13–16) and one-half (9–12) to more than 80% yellow (5–8). The decrease in chlorophyll and carotenoid content with increasing tissue senescence was accompanied by a loss of total protein and of specific polypeptides identified by electrophoresis and Western blotting. Heterogeneity in the rates at which photosynthetic proteins decreased during senescence could be related to differences in susceptibility to proteolysis conferred by location (soluble proteins are more labile than membrane components) and association with stabilizing components such as pigments. The abundance of senescence-related mRNAs was determined by Northern analysis using heterologous DNA probes and also cDNAs isolated from Arabidopsis by differential library screening. Expression of the plastid gene psbA increased until the most extreme stage of senescence, in contrast to the pattern of the protein it encodes, D1, which was almost undetectable in all but mature green tissue. Transcripts corresponding to two senescence-enhanced cDNAs from Brassica napus, LSC54 and LSC94, were strongly up-regulated in senescing Arabidopsis leaves. Two Arabidopsis cDNAs, LdeVA8 and LdeVA32, detected mRNAs of increasing abundance up to mid-senescence and decreasing thereafter. Another homologous clone, LdeVA43, hybridized with a transcript showing some enhancement in early senescence. Partial base sequences of LdeVA8 and LdeVA32 revealed homologies with genes encoding a metallothionein-like protein and catalase, respectively. LSC54 also encodes a putative metallothionein. The possible significance of the patterns of gene expression in senescing rosette leaves of A. thaliana is discussed.
Data files - Pore size and counterion effects on ionic transport of ZnSO₄ electrolyte in carbon slit pores via molecular dynamics

Field: Chemistry (Physical Sciences)

This repository contains the input files and selected output data from molecular dynamics simulations performed to study ion transport in ZnSO₄-based electrolytes and slit-shaped carbon nanopores. The simulations were performed to investigate the structure, dynamics, and transport behavior of Zn²⁺ and SO₄²⁻ ions under confinement and applied electric field, with relevance to electrochemical energy storage systems such as supercapacitors. The archive is organized into two main folders: Bulk Electrolyte Simulations:"bulk_electrolyte.tar" contains setup scripts and input files for generating and simulating ZnSO₄ aqueous electrolytes at different molar concentrations (0.5 M, 1 M, and 3 M). The workflow includes system preparation with Moltemplate, energy minimization, density adjustment, thermal equilibration, and production runs for evaluating viscosity and diffusion using Green–Kubo and MSD analysis. For more information about the content of each subfolder, see the internal README.txt file. Slit Pore Simulations:"carbon_slit_pores.tar" contains input files for non-equilibrium molecular dynamics simulations of a 3 M aqueous ZnSO₄ electrolyte flowing through slit-shaped nanopores under an external constant electric field. Each folder corresponds to a specific pore size, expressed in Angstroms, and includes system configuration files, LAMMPS run scripts, trajectory outputs, and restart files. Only one replica per pore size is included due to memory constraints. For more information about the content of each subfolder, see the internal README.txt file. All simulations were performed using LAMMPS. Input files and data are provided to ensure full reproducibility of the results discussed in the associated publication.
Postsecular Pilgrimage: The Idea of the Book

Field: Arts and Humanities (Social Sciences)

Ashrine turns into a pilgrimage site when its narratives or reported miracles, most successfully a combination of the two, appeal to a wider public. Pilgrims spread these news and narratives all over the pilgrim paths they use. They bring home devotional objects as souvenirs like shells from a beach holiday. Indeed, the pilgrimage to the tomb of St. James in Santiago de Compostela, a remote place in northwestern Spain near Finisterre, the end of Europe, spread the scallop—the "mussel of St. James" in many European languages—all over continental Europe. In October 1987, the Council of Europe declared the St. James pilgrimage route the first European Cultural Route because it links the formation of a modern European identity beyond nations to a medieval common European heritage. Most recently, the route experienced a huge revival. It now attracts all sorts of people interested in sportive or cultural hiking and various forms of self-experience. Further east, in a similarly remote place close to the French Pyrenees, Lourdes developed since the apparition of the Virgin Mary in the late nineteenth century a global attractiveness that spread the Lourdes Madonna, white with a blue girdle, all over the world. Lourdes grottos or at least symbols of this shrine are to be found in almost any Catholic community from New Orleans (USA) to Chennai (India), notwithstanding the large number of Catholics who think of it as kitsch. The Lourdes Madonna is an icon that brings Catholics from all over the world together, but you can also distinguish two different types of Catholics by asking if they like the spirituality associated with Lourdes or not.KeywordsInternational RelationPolitical TheoryLanguage GameWorld ReligionCatholic ChurchThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Antimicrobial Resistant Streptococcus pneumoniae

Field: Medicine (Health Sciences)

Introduction: Pneumococcal infections are important cause of morbidity and mortality. Knowledge of antimicrobial susceptibility patterns plays important role in the selection of appropriate therapy. Present study was undertaken to analyze the susceptibility patterns of pneumococcal isolates against commonly used antimicrobials with special reference to determination of minimum inhibitory concentration (MIC) of penicillin in a tertiary care hospital in eastern Nepal. Methods: Twenty-six strains of S. pneumoniae isolated from various clinical specimens submitted to microbiology laboratory were evaluated. All isolates were tested for antimicrobial susceptibility by disk diffusion method. MIC of penicillin was tested by broth dilution method. Results: Of the total isolates 19 (73%) were from invasive infections. Seven isolates were resistant to cotrimoxazole. No resistance to penicillin was seen in disk diffusion testing. Less susceptibility to penicillin (MIC 0.1-1.0 mg/L) was observed in five (17%) isolates. High level resistance to penicillin was not detected. One isolate was multidrug resistant. Conclusions: S. pneumoniaeisolates with intermediate resistance to penicillin prevail in Tertiary Care Hospital in eastern Nepal, causing invasive and noninvasive infections. As intermediate resistance is not detected in routine susceptibility testing, determination of MIC is important. It helps not only in the effective management of life threatening infections but is also essential in continuous monitoring and early detection of resistance. In addition, further study on pneumococcal infections, its antimicrobial resistance profile and correlation with clinical and epidemiological features including serotypes and group prevalence is recommended in future. Keywords: antimicrobial susceptibility pattern, penicillin, Streptococcus pneumoniae.
Different Fluorescent Staining Methods for Inducing of Apoptosis in Homocaryon with B37 of Maize by Helminthosporium maydis Race C(HMC) Toxin

Field: Agricultural and Biological Sciences (Life Sciences)

AO and EB fluorescent double staining and Hoechst 33258 fluorescent staining methods were used to detach the apoptosis of root cap cells.Detection of apoptosis and the change of its ratio induced by HMC toxin in the root cap cells detached from a pair of homokaryon B37-C and B37-N inbred line of maize.In contrast,the ratios of apoptosis of B37-C were 24.8%,58.2%,70.2%,and B37-N were 11.0%,25.7%,36.6% by AO and EB staining,after HMC-toxin with 50,100,150 μg/mL treated for 7h.The max ratios of apoptosis of B37-C and B37-N stained by AO and EB were 62.3% and 25.8%,respectively,after HMC toxin with 150 μg/mL treated for 4 h.And the ratios of apoptosis of B37-C were 32.5%,58.7%,74.5% and B37-N were 7.5%,22.3%,30.7% by Hoechst 33258 staining, after HMC-toxin with 50,100,150 μg/mL treated for 7 h.The max ratios of apoptosis of B37-C and B37-N stained by Hoechst 33258 were 62.3% and 19.3%,respectively,after HMC toxin with 150 μg/mL treated for 4 h.
Use of antibiotics. Sulphonamides, co-trimoxazole, and tetracyclines.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

SulphonamidesSulphonamides are the oldest chemotherapeutic agents whose introduction can be recalled by today's practising doctors.Although this gave them precedence of use in various treatments, they suffer from having been introduced before many of the general principles of chemotherapy had been established.They therefore sometimes acquired an unjustifiably poor reputation created by misuse, particularly in respect of dosage (see below).Furthermore, long exposure has given ample opportunity for bacterial resistance to develop.The availability of many sulphonamide derivatives with closely similar generic names has caused confusion, sometimes leading to additional therapeutic problems.Details of sulphonamides, including pharmacological properties and dosages available in Britain are given in the table; sulphonamides for topical use or specialised uses (salazo- pyrin, sulphapyridine) or non-absorbed derivatives for oral use are not included.Sulphonamides all act by inhibiting an early stage of bacterial folate synthesis.Although it is usually considered that all derivatives are more or less of equal potency, perhaps because of universal cross-resistance, there are differences in activity that might be usefully exploited in conditions when effective drug
Bro or Kook? The effect of dynamic member evaluation on incivility and resources in surf lineups

Field: Social Sciences (Social Sciences)

Purpose The purpose of this paper is to explore processes of group member evaluation and the interpersonal behavioral consequences of perceived group membership, within the context of a temporary group with evolving members. Design/methodology/approach Based on data from an autoethnographic study, the author investigates individual socialization into a new group, with a focus on how gender influences interpersonal evaluation processes. The author analyzes the interpersonal organizing behaviors of surf lineups, which are a male-dominated group that is continually socially constructed through changing membership. Findings Findings support an association between denial of group membership and outcomes including incivility and denial of resources. The author develops a model of dynamic member evaluation, which identifies how group members continuously evaluate proximate individuals at the stage of impending membership, with identified outcomes of those evaluations. Research limitations/implications A limitation of this design is that it generalizes organizing processes from a non-traditional setting to more traditional organizations. The model predicts dynamic member evaluation as individuals organize into groups in a shifting environment, with implications for scholarship on intragroup dynamics, incivility, gender and inclusion. Practical implications Understanding dynamic member evaluation provides a path for aspiring or new group members to employ signaling behaviors, which can help to prevent incivility and enhance resource availability. Evidence suggests that the proactive act of signaling competence may help to foster inclusion at the stage of impending membership, which is particularly important given how impending member evaluation is subject to bias. Such understanding also raises the awareness of how majority group members can manage their evaluations and refrain from letting judgments of impending members impact interpersonal behaviors, which may prevent incivility. Social implications The findings and resultant model illustrate the process and experience of group inclusion, showing how incivility can manifest and resources can be limited toward impending members who are excluded. Originality/value This study contributes to scholarship by introducing dynamic member evaluation, including the content and process of evaluation at the stage of impending membership, how resultant selective incivility can be predicted, and potential contagion effects of such incivility.
Bile acid profile in healthy pregnant women and patients with intrahepatic cholestasis of pregnancy (ICP).

Field: Medicine (Health Sciences)

<p>Results are expressed as mean ± SD, P-level indicates statistical significance using Mann-Whitney test.</p><p>CA (cholic acid), CDCA (chenodeoxycholic acid), DCA (deoxycholic acid), UDCA (<b>ursodeoxycholic acid</b>), GCA (glycocholic acid), GCDCA (glycochenodeoxycholic acid), GDCA (glycodeoxycholic acid), GLCA (glycolithocholic acid), GUCDA (glycoursoeodeoxycholic acid), TCA (taurocholic acid), TCDCA (taurochenodeoxycholic acid), TDCA (taurodeoxycholic acid), TLA (taurolithocholic acid), and TUDCA (tauroursodeoxycholic acid). Bile acids species are expressed as µM.</p>
Contracting Strategy Decision Framework for Highway Maintenance

Field: Decision Sciences (Social Sciences)

Billions of dollars are expended annually on maintenance outsourcing to preserve the existing highway network. Selection of the activities to be outsourced and the type of contracting strategy to implement primarily depend on the judgment of highway maintenance directors. While there are a large number of maintenance contracting strategies being used worldwide, maintenance directors often make their selections based on contracting practices they have used successfully in the past rather than by examining all possible methods and choosing an appropriate contracting strategy that meets specific selection criteria. In fact, there currently is no systematic method for choosing an appropriate maintenance contracting strategy. This paper contributes to the body of knowledge on the maintenance contracting selection process by summarizing 13 strategies being used worldwide to deliver maintenance services, identifying specific selection criteria that should be considered when making a decision, and presenting a decision framework that will aid highway maintenance personnel with the selection of effective maintenance contracting strategies.
Narrative Technique in the Qur’ān and in Early Poetry

Field: Arts and Humanities (Social Sciences)

Un des dogmes des musulmans est que le Coran n'est pas de la poesie. Sa metrique n'est pas celle de la poesie. Il utilise le rythme et les assonances, mais pas a la maniere de la poesie. L'A. propose une analyse comparative du Coran et de la poesie ancienne
Abstract 3050: Targeting SREBP-driven transcriptional programs in metastatic prostate cancer

Field: Medicine (Health Sciences)

Prostate cancer (PCa) is the most commonly diagnosed cancer and the second leading cause of cancer-related deaths among men in the United States. Metastasis is the major cause of mortality associated with prostate cancer, and despite the availability of targeted therapeutic agents, metastatic prostate cancer remains a lethal disease. Therefore, there is a significant unmet need to identify new drug targets and develop novel targeted therapeutic agents. Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors, comprising SREBP-1 and SREBP-2, that govern lipid homeostasis by regulating the expression of numerous enzymes involved in fatty acid and cholesterol synthesis (lipogenesis). The role of SREBPs in regulating non-lipogenic transcriptional programs is beginning to be elucidated. Published findings associate perturbation of SREBP-dependent transcriptional programs in the development, progression, and metastasis of various cancers, including PCa. Our analysis of publicly available patient datasets revealed increased gene expression for SREBPs in prostate tumors compared to normal prostate. Further, we discovered significantly higher gene expression for SREBPs in metastatic samples compared to primary prostate tumors. Moreover, we found significantly elevated levels of SREBPs in more invasive PC3M and C4-2B compared to the less invasive PC3 and LNCaP prostate cancer cell lines. Hence, we hypothesized that pharmacological inhibition of SREBPs might be an effective therapeutic strategy against metastatic prostate cancer. We have developed a novel boron-containing compound, BF175, which inhibits the expression and transcriptional activity of SREBPs, but the information on the anticancer action of BF175 in various cancers, including prostate cancer, is very limited. In this study, we investigated the SREBP-mediated anticancer activity of BF175 in prostate cancer. We found that BF175 inhibited the viability, proliferation, and metastatic potential as well as induced apoptosis in all prostate cancer cell lines tested. We also confirmed that BF175 inhibited the expression of SREBPs in the tested prostate cancer cell lines. Of note, BF175 exhibited significantly higher potency as an anticancer agent in more invasive prostate cancer cell lines compared to their less invasive counterparts. Taken together, our results demonstrate that BF175 shows promise as a novel anticancer agent that may improve outcomes in lethal metastatic prostate cancer. Citation Format: Prashanth Parupathi, Lakshmi Sirisha Devarakonda, Enkiel Francois, Bhaskar C Das, Avinash Kumar. Targeting SREBP-driven transcriptional programs in metastatic prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 3050.
Penicillin susceptibility of Streptococcus pneumoniae in a private pediatric hospital in Houston, Texas

Field: Medicine (Health Sciences)

Of 493 isolates of Streptococcus pneumoniae, 14 were found to have decreased penicillin susceptibility as determined by the oxacillin disk test. Of these 14 isolates, 4 were relatively resistant by quantitative susceptibility studies and 1 was penicillin resistant (MIC, 2 micrograms/ml). This is the first confirmed penicillin-resistant isolate in the Houston, Tex., area.
Evaluation of the use of a new compact disc for auditory perceptual assessment in the elderly.

Field: Health Professions (Health Sciences)

The present study examined the performance of 40 normal-hearing young adults and 38 elderly adults, some normal hearing and some hearing impaired, on the Department of Veterans Affairs' new compact disc (VA-CD) for auditory perceptual assessment. Principal-components factor analyses were performed on the test scores from each group of subjects with very similar results obtained from each group in terms of the number of factors identified (3), the percentage of variance explained by these factors individually and collectively (about 72%), and the association of various test scores with each factor. The 10 tests examined here were found to be associated with three underlying factors identified as a general speech-understanding ability (about 42% of variance), temporal sequencing capacity (about 18% of variance), and processing ability under conditions of dichotic competition (about 12% of variance). Among the elderly, hearing loss was strongly and negatively associated with general speech-recognition ability, whereas age was moderately associated with the other two factors. Test scores for several measures of auditory perceptual processing were negatively affected by the presence of peripheral hearing loss in the elderly even when administered at the highest recommended presentation level (90 dB SPL). In addition, some tests among those examined were found to have inadequate test-retest reliability for clinical use with the elderly.
A Transputer Based Multimedia System

Field: Computer Science (Physical Sciences)

This paper presents the problems associated with multimedia interfaces for a network environment and proposes solutions to overcome them. The applications and characteristics of multimedia are discussed to provide a good understanding of the interface requirements for such systems. Transputers are applied as the parallel processing elements in a high performance multimedia system which provides an interface between the host system and the network to cater for the wide variety of traffic loads that the multimedia systems present.
[Automatic extraction of vertebral landmarks from ultrasound images].

Field: Computer Science (Physical Sciences)

Some forms of myopathies such as Duchenne muscular dystrophy cause a progressive degeneration of the patient's muscles. This results in the development of scoliosis, which increases in severity over time. The clinical standard for monitoring scoliosis is to perform an X-ray on a regular basis. Unfortunately, repeated exposure to X-rays is harmful to the patient's health. Ultrasound imaging is a radiation-free modality that uses ultrasound (US) waves. However, the interpretation of vertebral ultrasound images is often difficult due to the variable quality of the image. In order to tackle this challenge, we present a method to localize the vertebrae on US images automatically. The validation of this reproducible approach suggests that it would be possible, in the long term, to replace part of the X-ray exams by US imaging.
Measurement Error

Field: Mathematics (Physical Sciences)

Abstract Recognition that measurement error in the independent (predictor) variable of data used for regression modeling necessitates special methods of model fitting dates back to the late 1800s. In the ensuing 100 years attention was devoted almost entirely to measurement error in linear regression models, at which time advances in computing opened the door to the nonlinear statistical modeling generally, and to the study of measurement error in nonlinear regression modeling in particular. This article contains an introduction to the problem of measurement error in regression using linear regression measurement error models to illustrate key ideas. It includes a discussion of the types of measurement error commonly studied (classical and Berkson, differential and nondifferential) and how those types arise in practice. A summary of the consequences of ignoring measurement error when analyzing data measured with error is presented, with detailed results given for simple and multiple linear measurement error models. Pointers to the literature on both linear and nonlinear measurement error models are provided.