jimnoneill/paper-to-field-training huggingface dataset:
HGG-05. CAN MULTIMODAL IMMUNOTHERAPY REPLACE RADIOCHEMOTHERAPY IN COMPLETELY RESECTED ADULT GBM?

Field: Medicine (Health Sciences)

Adults with GBM always relapse, even after complete resection. Therefore radiotherapy with broad margins around the resection cavity is mandatory part of the initial standard of care for these patients, aimed to maximize the local tumor control. Chemotherapy is aimed as function as radiosensitizer and to prolong disease-free survival. Nevertheless, most patients show local and/or even distant tumor re-occurrence more or less shortly after multimodal primary treatment. Hypotheses for this are the infiltrative character of the tumor cells, the residing non-dividing glioma cancer stem cells, chemoresistance, etc. IOZK was confronted with a patient (EORTC RPA class IV) who refused radiochemotherapy and maintenance chemotherapy after complete resection of a left occipital glioblastoma. Pathology showed tissue necrosis, angiogenesis, mitosis and atypical tumor cell nuclei. Molecular classification revealed glioblastoma, IDH wildtye, subtye RTK I. After immunodiagnostic blood sampling, the patient was treated with multimodal immunotherapy consisting of 2 cycles of 6 days Newcastle Disease Virus (NDV) infusions and local modulated electrohyperthermia (mEHT) sessions plus an autologous DC vaccine loaded with serum-derived NDV/mEHT-induced antigenic microparticles + NDV, and additionally four more treatments with NDV infusions + mEHT. Treatment was conducted without any side effect. We observed the induction of tumor antigen-specific IFN-producing T cells measured upon ex vivo stimulation with autologous DCs loaded with a GBM cell line in ELISPOT. At time of writing, 15 months after resection, the patient remains in complete remission with optimal Karnofsky performance index and good quality of life. The % PFS at 12 months in the Stupp 2005 paper is for the total group of patients with radiotherapy alone 9.1% (95%CI 5.8–12.4m). The patient history points to a potential change in paradigm that microscopic infiltrating GBM tumor cells might be brought under permanent control through the combined action of NDV, mEHT and the induction of memory T cells.
Anti-obesity mechanisms elucidation of essential oil components from Artemisiae Argyi Folium (Aiye) by the integration of GC-MS, network pharmacology, and molecular docking

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Recently, the global epidemic of obesity is increasing significantly. Obesity is treated with anti-obesity medications and surgery and complications related to these treatments prompt the search of phytochemicals that confer anti-obesity effects. Artemisiae Argyi Folium (Aiye), a Chinese herb used as both food and medicine, exhibits potent anti-obesity effects. Aiye essential oil components are responsible for lipase activity inhibition, intestinal barrier protection, and blood lipid regulation effects. The current research aims to identify the anti-obesity essential oil components of Aiye through the integration of GC-MS, network pharmacology, and molecular docking. In present study, the Aiye essential oil components were identified by GC-MS analysis. Network pharmacology and molecular docking were integrated to predict the anti-obesity mechanisms of Aiye essential oil components. In total, 49 essential oil components were identified, containing 308 anti-obesity targets. The network pharmacology analysis revealed that the essential oil components may combat obesity through the Wnt signaling pathway, PI3K-Akt signaling pathway, MAPK signaling pathway, prolactin signaling pathway, and cAMP signaling pathway, etc. For molecular docking, there were 99 out of 140 with a binding affinity of less than −5 kcal/mol, indicating a moderate binding between essential oil components and targets. The present study revealed 308 potential anti-obesity targets of 49 essential oil components of Aiye. More than 70% of the binding between components and targets had moderate interaction. More than five anti-obesity signaling pathways of 49 Aiye essential oil components were identified. Therefore, the current research indicated that the essential oil components of Aiye may confer anti-obesity benefits.
Early response to chemotherapy in children with Langerhans cell histiocytosis predicts long-term disease-free survival

Field: Medicine (Health Sciences)

Background: Langerhans cell histiocytosis (LCH) is a rare clonal malignancy of the monocyte-macrophage system. Patients with lesions in “risk organs” have significantly higher risk of mortality than patients with lesions limited to “non-risk” sites. The influence of early response to therapy on long-term survival in this heterogeneous multi-system disease was analyzed. Methods: During a 7-year period, we retrospectively analyzed the findings in 24 consecutive patients who required systemic chemotherapy for LCH [single system with multifocal bone involvement and multisystem involvement with or without risk organ (RO) involvement]. All patients were started on vinblastine and prednisolone. Progressive disease was treated with salvage protocols or targeted therapy. Positron emission tomography-computed tomography (PET-CT)/conventional CT based response assessment was performed at week 6 of chemotherapy, and if needed after week 12 of chemotherapy. Results: MFO bone, MS RO neg , and MS RO pos LCH was observed in 3, 4, and 17 patients, respectively. Age range of patients varied from 1 month–7 years (median = 18 months). The EFS and OS were 100% and 100% for MFO bone, 50% and 100%, respectively, for MS RO neg and 35% and 52%, respectively, for MS RO pos . OS was 93% and 100% for CR attained at 6 and 12 weeks respectively regardless of the risk status ( P < 0.01). Conclusion: Rapid early response, that is, complete remission at 6 and 12 weeks was associated with significantly improved overall survival. In slow responders, early salvage with alternative regimens or targeted therapy may result in better outcomes.
Abuse of the right by the consumer

Field: Social Sciences (Social Sciences)

The monograph examines the mechanism by which a consumer exercises his or her rights, including in the presence of signs of dishonesty. A legally protected interest is proposed as the main criterion for qualifying a consumer's actions (inaction) for abuse of a right. A system of measures has been developed to counteract such behavior, aimed at eliminating shortcomings in the legal regulation of relations with consumers. It is intended for students, postgraduates, teachers, practicing lawyers and anyone who is interested in the problems of exercising subjective rights in the retail market of goods, works and services.
PROGRESS IN THE KNOWLEDGE OF $C_{2}H_{2}$ SPECTROSCOPIC PARAMETERS IN THE IR

Field: Physics and Astronomy (Physical Sciences)

Author Institution: Harvard-Smithsonian Center for Astrophysics, Atomic and Molecular Physics Division; Laboratoire de Physique Mol\'eculaire et Applications, CNRS, case courrier 76, Universit\'e Pierre-et-Marie-Curie; Groupe de Spectrom\'etrie Mol\'eculaire et Atmosph\'erique, Universit\'e de Reims-Champagne-Ardenne, CNRS
The Impact of COVID-19 on Quality of Life of Dentists in Health Care Centers in Saudi Arabia

Field: Health Professions (Health Sciences)

Background:The aim of this study is to assess the effectiveness of COVID-19 on quality of life of dentists at health care centers in Saudi Arabia.Material and Methods: This study was conducted for two weeks.Sample was selected randomly and included 300 dentists from different specialty.Questionnaire about demographic data and effect of Covid-19 on quality of life were used.Results: A total of 204 (68%) of dentists who replied was work in government sector.Their average age ranges from 20 years to 50 years and most of the dentist who answered the questionnaire (45%) work for more than 10 years of service.The second part about the effect of the virus on the quality of life most of them (93%) they feel their safety is in risk during working hours.87% of the participant dentist they had a symptom of depression and anxiety and (70%) of them they worried about being a source of infection for their family.For the dentists who work in private sector (40%) of them afraid from lose their job and facing a financial problem.Conclusion: Regarding to the result we found that COVID-19 pandemic had a negative effect on quality of life for the dentist in both sector the government and private.
Enhanced\nChlorine and Bromine Atom\nActivation by Hydrolysis of Halogen Nitrates from\nMarine Aerosols at Polluted Coastal Areas

Field: Environmental Science (Physical Sciences)

Detailed\nmultiphase chemistry box model studies are carried out,\ninvestigating halogen radical activation at polluted coastal areas.\nSimulations are performed for a nonpermanent cloud and a cloud-free\nscenario and reveal that ClNO<sub>2</sub> photolysis and ICl photolysis\nare crucial for gas-phase Cl atom activation. In the cloud scenario,\nthe integrated ClNO<sub>2</sub> and ICl photolysis rates are 3.7 ×\n10<sup>7</sup> and 3.1 × 10<sup>7</sup> molecules cm<sup>–3</sup> s<sup>–1</sup>. In the cloud-free scenario, the integrated\nClNO<sub>2</sub> and ICl photolysis rates are 8.1 × 10<sup>7</sup> and 3.6 × 10<sup>7</sup> molecules cm<sup>–3</sup> s<sup>–1</sup>. The simulations show larger contributions of ClNO<sub>2</sub> photolysis in the morning and higher ones of ICl photolysis\nduring afternoon. Throughout the simulation, average contributions\nto Cl atom activation in the cloud and cloud-free scenarios by ClNO<sub>2</sub> photolysis are 42% and 62% and by ICl photolysis 35% and\n28%, respectively. ICl is formed through an aqueous-phase reaction\nof HOI with chloride. Two thirds of the formed ICl is released into\nthe gas phase. The residual third reacts with bromide, creating IBr.\nOverall, the simulations emphasize the crucial role of INO<sub>3</sub> hydrolysis for Cl and Br atom activation in polluted coastal areas.\nTherefore, it needs to be considered in chemical transport models\nto improve air quality predictions.
Comparative efficacy and safety of 4 atypical antipsychotics augmentation treatment for major depressive disorder in adults: A systematic review and network meta-analysis

Field: Medicine (Health Sciences)

Background: Atypical antipsychotic (AAP) augmentation is an alternative strategy for patients with major depressive disorder (MDD) who had an inadequate response to antidepressant therapy (ADT). We aimed to compare and rank the efficacy and safety of 4 AAPs in the adjuvant treatment of MDD. Methods: We searched randomized controlled trials (RCTs) published and unpublished from the date of databases and clinical trial websites inception to April 30, 2023. The evidence risk of bias (RoB) and certainty are assessed using the Cochrane bias risk tool and grading of recommendations assessment, development, and evaluation (GRADE) framework, respectively. Using network meta-analysis, we estimated summary risk ratios (RRs) or standardized mean difference (SMD) based on the random effects model. Results: 56 eligible studies comprising 11448 participants were included. In terms of primary efficacy outcome, compared with placebo (PBO), all AAPs had significant efficacy (SMD = −0.40; 95% CI, −0.68 to −0.12 for quetiapine (QTP); −0.35, −0.59 to −0.11 for olanzapine (OLA); −0.28, −0.47 to −0.09 for aripiprazole (ARI) and −0.25, −0.42 to −0.07 for brexpiprazole (BRE), respectively). In terms of acceptability, no significant difference was found, either agents versus agents or agents versus PBO. In terms of tolerability, compared with the PBO, QTP (RR = 0.24; 95% CI,0.11–0.53), OLA (0.30,0.10–0.55), ARI (0.39,0.22–0.69), and BRE (0.37,0.18–0.75) were significantly less well tolerated. 8 (14.2%) of 56 trials were assessed as low RoB, 38 (67.9%) trials had moderate RoB, and 10 (17.9%) had high RoB; By the GRADE, the certainty of most evidence was low or very low. Conclusion: Adjuvant AAPs had significant efficacy compared with PBO, but treatment decisions must be made to balance the risks and benefits.
Use of NOx- microsensors to estimate the activity of sediment nitrification and NOx- consumption along an estuarine salinity, nitrate, and light gradient

Field: Environmental Science (Physical Sciences)

Microprofiles of nitrate plus nitrite (NOx -) were measured in sediment cores sampled at 6 stations along a nitrate and salinity gradient and a depth transect in Randers Fjord, Denmark. Rates of NOx - production and consumption were calculated from the concentration profiles to describe the variation of these processes under in situ conditions. A microscale biosensor for NOx - was used to obtain NOx - profiles in darkness and under in situ light conditions. This new tool for nitrate plus nitrite measurements in saline environments made it possible to measure NOx - profiles with submicromolar resolution and without interference from chemical species other than nitrous oxide. The NOx - concentration in the inner and middle part of the estuary was very high (55 to 220 μM). The range of NOx - consumption rates found here (47 to 577 μmol N m-2 h-1) were within the range of denitrification rates found in similar environments (measured by 15N isotope techniques). The NOx - concentration in the water was low at the outermost part of the estuary, and all NOx - diffusing into the sediment was consumed in the oxic zone (top 1 mm) of the sediment. In this study, NOx - consumption was not closely coupled to nitrification and depended mostly on NOx - (mainly nitrate) from the overlying water. The NOx - consumption rates were correlated with NOx - concentration in the overlying water, but the sediment was a sink for NOx - only at the highest NOx - concentrations. The effect of changing light conditions on NOx - consumption was significant at the station with the highest NOx - level but not at other stations.
Case Study on ADHD: A Detailed Clinical Assessment Diagnosis and Therapeutic Intervention Plan

Field: Medicine (Health Sciences)

The purpose of this case study was to explore the behavioral, emotional, and academic challenges of a 7-year-old girl diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD), Combined Presentation. ADHD is a common neurodevelopment disorder, and its symptoms often impair various aspects of a child's functioning. Previous research highlights the role of neurobiological and environmental factors in the development and exacerbation of ADHD symptoms. This qualitative case study used purposive sampling to select A.A., who was referred for psychological evaluation due to disruptive behavior and academic struggles. Data collection involved clinical observation, parental interviews, and standardized ADHD rating scales. The analysis revealed significant symptoms of inattention, hyperactivity, and emotional dysregulation, which were severely affecting A.A.'s academic performance and social interactions. Results indicated that A.A. exhibited high levels of impulsivity, poor emotional regulation, and difficulties with task completion. The findings also suggested that familial factors, such as parental aggression and inconsistent discipline, may have contributed to the severity of her symptoms. In conclusion, this study emphasized the importance of adopting a holistic approach to ADHD treatment, addressing both the neurobiological aspects and environmental stressors. The limitations of the study, including its single-case design and reliance on subjective reports, suggest the need for future research with larger sample sizes to examine the long-term impact of ADHD and the role of family dynamics in symptom severity.
Quantization and Entropy Coding in the Versatile Video Coding (VVC) Standard

Field: Computer Science (Physical Sciences)

The paper provides an overview of the quantization and entropy coding methods in the Versatile Video Coding (VVC) standard. Special focus is laid on techniques that improve coding efficiency relative to the methods included in the High Efficiency Video Coding (HEVC) standard: The inclusion of trellis-coded quantization, the advanced context modeling for entropy coding of transform coefficient levels, the arithmetic coding engine with multi-hypothesis probability estimation, and the joint coding of chroma residuals. Beside a description of the design concepts, the paper also discusses motivations and implementation aspects. The effectiveness of the quantization and entropy coding methods specified in VVC is validated by experimental results.
Supplementary Figure S1 from Preclinical Development of a Bispecific Antibody that Safely and Effectively Targets CD19 and CD47 for the Treatment of B-Cell Lymphoma and Leukemia

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

<p>Supplementary Figure S1 shows shows the percentage of in vitro phagocytosis of Raji cells by macrophages with NI-1701 or CD19/CD47hi biAb.</p>
Influence of long‐stay jugular catheters on hemostatic variables in healthy dogs

Field: Veterinary (Health Sciences)

Abstract Objective To compare hemostatic variables performed on blood samples obtained from indwelling jugular catheters or direct venipuncture over a 72‐hour period. Design Prospective experimental study. Setting University research laboratory. Animals Five healthy neutered male purpose‐bred Beagle dogs. Interventions Each dog was sedated to facilitate placement of a long‐stay 20‐Ga polyurethane IV catheter into the jugular vein. Blood samples were obtained from the preplaced catheters at 4 time points corresponding to 0, 24, 48, and 72 hours relative to placement. Blood samples were also obtained by direct venipuncture of a peripheral vein using a 21‐Ga butterfly catheter and evacuated blood tubes at the same time points. Platelet count, platelet closure time, prothrombin time, activated partial thromboplastin time, fibrinogen, and kaolin‐activated thromboelastography were performed on these paired samples at each time point. The patency of the indwelling catheters was maintained by flushing every 6 hours with heparinized saline. Measurements and Main Results No significant differences were identified in any of the hemostatic variables obtained by either blood collection technique at any time point during the study ( P > 0.05). There was also no significant day‐to‐day variation in any catheter‐derived hemostatic variable obtained from individual dogs identified over the course of the study. Conclusions These data suggest that accurate hemostatic variables may be obtained using blood collected from indwelling jugular catheters, maintained with heparinized saline for at least 72 hours, in healthy dogs.
Learning to Order for Inventory Systems with Lost Sales and Uncertain Supplies

Field: Decision Sciences (Social Sciences)

We consider a stochastic lost-sales inventory control system with a lead time $L$ over a planning horizon $T$. Supply is uncertain, and is a function of the order quantity (due to random yield/capacity, etc). We aim to minimize the $T$-period cost, a problem that is known to be computationally intractable even under known distributions of demand and supply. In this paper, we assume that both the demand and supply distributions are unknown and develop a computationally efficient online learning algorithm. We show that our algorithm achieves a regret (i.e. the performance gap between the cost of our algorithm and that of an optimal policy over $T$ periods) of $O(L+\sqrt{T})$ when $L\geq\log(T)$. We do so by 1) showing our algorithm cost is higher by at most $O(L+\sqrt{T})$ for any $L\geq 0$ compared to an optimal constant-order policy under complete information (a well-known and widely-used algorithm) and 2) leveraging its known performance guarantee from the existing literature. To the best of our knowledge, a finite-sample $O(\sqrt{T})$ (and polynomial in $L$) regret bound when benchmarked against an optimal policy is not known before in the online inventory control literature. A key challenge in this learning problem is that both demand and supply data can be censored; hence only truncated values are observable. We circumvent this challenge by showing that the data generated under an order quantity $q^2$ allows us to simulate the performance of not only $q^2$ but also $q^1$ for all $q^1
Nutritional, physicochemical and sensory evaluation of biscuits enriched withUlva sp. from Gunungkidul coast

Field: Agricultural and Biological Sciences (Life Sciences)

Ulva sp. a seaweed commonly found on Gunungkidul coast, had the potential as a source of functional food that contained high antioxidants, protein and dietary fiber. Ulva sp. was developed into biscuits, one of the most popular foods in Indonesia. This study aimed to investigate the physicochemical and sensory evaluation of biscuits enriched with Ulva sp. The nutritional value, antioxidant activity, dietary fiber, texture, color, appearance and sensory evaluation were studied. Ulva sp. was collected from Gunungkidul coast and treated using 5% lime for fishy-smell removal, then dried to produce Ulva sp. powder. The Ulva sp. powder was used for biscuit enrichment with 0% powder (STD), 3% powder (BC3), 5% powder (BC5) and 7% powder (BC7) substitution. Biscuits enriched with Ulva sp. increased the protein, fat, and ash content, while the carbohydrate content decreased (p<0.05). The more Ulva sp. was substituted in biscuits, the higher antioxidant activities and dietary fibers were measured (p<0.05). The crunchiness of BC5 (139.95±28.84 Nmm) was high, and no significant difference with STD (393.05±34.11 Nmm), while the crispiness and the hardness of enriched biscuits were lower than STD. The lightness (L*), redness (a*), and yellowness (b*) of enriched biscuits were lower than STD because the Ulva sp. powder contributed to giving dark-greenish colors. Sensory evaluation showed that BC5 was the most well-liked by the panellist in terms of its appearance, aroma, taste, flavor, texture, aftertaste, and overall (there was no difference with STD). Thus, biscuits enriched with Ulva sp. were confirmed to improve nutritional and physicochemical, and it has sensory evaluation acceptance.