jimnoneill/paper-to-field-training huggingface dataset:
PDF Download Essential Woodworking Hand Tools Full PDF

Field: Arts and Humanities (Social Sciences)

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Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The ATP-dependent proteolytic cell-free system from reticulocytes has been resolved into three components, each of which is absolutely required for acid solubilization of 125I-labeled bovine serum albumin radioactivity. In addition to the previously reported heat-stable polypeptide [Ciechanover, A., Hod, Y. & Hershko, A. (1978) Biochem. Biophys. Res Commun. 81, 1100-1105], we now describe a protein of high molecular weight (approximately 450,000) that is labile at 42 degrees C. The extremely heat-labile factors is remarkably stabilized by ATP. GTP and CTP, which do not stimulate protolysis, do not stabilize this factor. Adenylate nucleotides such as ADP or the nonhydrolyzable beta,gamma imido or methylene analogues of ATP cause stabilization although they do not activate proteolysis. A third protein component of the protease system, stable at 42 degrees C, has been separated from the heat-labile species by salt precipitation. All three components are required with ATP for proteolytic activity, but thus far only the heat-labile factor has been shown to interact directly with ATP.
Influence of Reaction Time on Phosphate Adsorption

Field: Environmental Science (Physical Sciences)

The influence of reaction time on P adsorption was studied using four representative soils of Tamil Nadu viz., red, black, laterite and alluvial soils. The equilibrating solution employed was 0.01 M CaCl2+KH2PO4 at 28°C±1. The results showed that P adsorption was characterised by an initial fast reaction followed by a slow process in all the soils. The rate of P adsorption was high in Ootacamund high level laterite soil, while it was slow in Tirurkuppam alluvial soil. Reasonably stable level of P in equilibrium solution was attained after 6 days in all the soils, excepting that of Kovilpatti black soil and alluvial soils which required a minimum of 8 days.
Encyonema capixabense sp. nov. (Cymbellales, Bacillariophyceae): a widespread diatom in Brazilian rivers first described from the Rio Doce Basin (southeastern Brazil)

Field: Agricultural and Biological Sciences (Life Sciences)

A new diatom species, Encyonema capixabense sp. nov., is described from periphytic material collected during a monitoring survey of the Rio Doce, southeastern Brazil. Its morphology is documented using light and scanning electron microscopy. This taxon is characterized by i) semi-lanceolate valves, ii) a slightly tumid ventral margin with convergent striae, and iii) valve ends deflected toward the ventral side. The new species is compared with morphologically similar taxa within the genus based on the literature. We confirmed that the new species was previously recorded under different names in several Brazilian studies and exhibits a broad occurrence in rivers. In this study, it dominates periphyton communities in mesotrophic lotic environments. Our results emphasize the need for increasing efforts to better understand the flora of poorly studied regions.
Pengaruh Viral Marketing, Product Quality, Dan Price Terhadap Purchase Decision

Field: Business, Management and Accounting (Social Sciences)

The rapid development of skincare industry has created business rivalry in this sector. The dynamic consumer preferences and the possibility for variety seeking require companies in this business to recognize factors affecting purchase decision in order to win the competition. This research aims to identify the effects of viral marketing, product quality, and price on the decision to purchase Skintific products by studying the users of TikTok Shop. The respondents of this quantitative explanatory research were selected using non-probability sampling method and purposive sampling technique with the criteria of people with the minimum age of seventeen years who have seen Skintific ads in TikTok Shop and have bought and used the product after making purchases from the shop. The validity, reliability, and the classical assumption teste were conducted in the Statistical Package for Social Sciences (SPSS), while the data was analyzed using multiple linear regression. The results of the hypothesis testing concerning the partial and simultaneous effect have led to findings that viral marketing (X1), product quality (X2), and price (3) have positive and significant effects on the decision to purchase Skintific products. Abstrak Perkembangan industri skincare yang sangat pesat berdampak pada ketatnya rivalitas dalam sektor usaha perawatan kecantikan atau skincare. preferensi konsumen yang dinamis dan adanya kemungkinan untuk melakukan variety seeking membuat perusahaan skincare harus mengidentifikasi faktor yang mempengaruhi keputusan pembelian agar dapat memenangkan persaingan. Penelitian ini bertujuan untuk mengetahui pengaruh viral marketing, product quality dan price terhadap purchase decision produk Skintific (studi pada konsumen TikTok Shop). Jenis penelitian ini adalah explanatory research dengan metode kuantitatif. Penelitian ini menggunakan sampel sebanyak 100 responden, Pengambilan sampel menggunakan teknik non probability sampling dengan metode purposive sampling. Kriteria responden yang dibutuhkan dalam penelitian ini adalah berusia minimal 17 tahun, pernah melihat iklan Skintific di TikTok Shop dan pernah membeli dan menggunakan produk Skintific melalui TikTok Shop. Penelitian ini menggunakan Statistical Package for the Social Sciences (SPSS) untuk melakukan uji validitas, uji reliabilitas dan uji asumsi klasik. Teknik analisis data menggunakan uji regresi linear berganda. Uji hipotesis dilakukan untuk menguji hipotesis secara parsial dan simultan. Berdasarkan hasil pengujian hipotesis diperoleh data variabel viral marketing (X1), product quality (X2), dan price (X3) masing-masing berpengaruh secara positif dan signifikan secara parsial terhadap purchase decision produk Skintific.
New Results From Gerda Phase Ii

Field: Physics and Astronomy (Physical Sciences)

The observation of neutrinoless double beta (0νββ) decay would establish both the violation of lepton number conservation and the Majorana nature of the neutrino, as well as constrain the neutrinomass hierarchy and scale. GERDA reached an important milestone in the search for 0νββ decay with ⁷⁶Ge by achieving a half-life sensitivity of 10²⁶ years. This is made possible by the background-free conditions in GERDA and by a factor of two increase in exposure since the last data release in 2017. New results will be presented together with the details of background reduction techniques.
Studies on the noradrenaline alpha-receptor. I. Techniques of receptor isolation. The distribution and specificity of action of N-(2-bromoethyl)-N-ethyl-1-naphthylmethylamine, a competitive antagonist of noradrenaline.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Studies have been made of the potential usefulness of adrenergic blocking 2-halogenoethylamines for labeling time α-receptor. The uptake of 3 H-labeled N -(2-bromoethyl)- N -ethyl- N -1-naphthylmethylamine ( 3 H-SY.28) by rabbit vas deferens was shown to be nonspecific and the 2-halogenoethylamine apparently showed little specificity for the α-receptor. In an attempt to obtain greater specificity, rabbit aorta and vas deferens were pretreated with N,N -dimethyl-2-bromo-2-phenylethylamine, a short-lasting irreversible α-receptor antagonist, prior to treatment with 3 H-SY.28. Tissues pretreated with the short-lasting antagonist should take up less 3 H-SY.28 and the difference between this uptake and that of controls should reflect the concentration of α-receptor material. However, this treatment did not afford any significant protection against the uptake of 3 H-SY.28. The possible protective effects of various amines against labeling by 3 H-SY.28 were also investigated: no correlation could be found between the protective ability of these amines and their direct or indirect sympathomimetic activities. An investigation was also made of the finding that trypsin can reverse the blockade of 3 H-SY.28. It was concluded that the recovery of response following trypsin is probably unrelated to α-receptor regeneration. The distribution of 3 H-SY.28 and its corresponding alcohol was studied in rats. Our results suggest that the prolonged tissue retention of radioactivity following 3 H-SY.28 is probably due to the high binding capacities of tissues for 3 H-SY.28 alcohol rather than to the presence of high concentrations of covalently bound 3 H-SY.28.
Pharmacodynamic assays to facilitate preclinical and clinical development of pre‐mRNA splicing modulatory drug candidates

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract The spliceosome has recently emerged as a new target for cancer chemotherapy and novel antitumor spliceosome targeted agents are under development. Here, we describe two types of novel pharmacodynamic assays that facilitate drug discovery and development of this intriguing class of innovative therapeutics; the first assay is useful for preclinical optimization of small‐molecule agents that target the SF 3B1 spliceosomal protein in animals, the second assay is an ex vivo validated, gel‐based assay for the measurement of drug exposure in human leukocytes. The first assay utilizes a highly specific bioluminescent splicing reporter, based on the skipping of exons 4–11 of a Luc‐ MDM 2 construct, which specifically yields active luciferase when treated with small‐molecule spliceosome modulators. We demonstrate that this reporter can be used to monitor alternative splicing in whole cells in vitro. We describe here that cell lines carrying the reporter can be used in vivo for the efficient pharmacodynamic analysis of agents during drug optimization and development. We also demonstrate dose‐ and time‐dependent on‐target activity of sudemycin D6 ( SD 6), which leads to dramatic tumor regression. The second assay relies on the treatment of freshly drawn human blood with SD 6 ex vivo treatment. Changes in alternative splicing are determined by RT ‐ PCR using genes previously identified in in vitro experiments. The Luc‐ MDM 2 alternative splicing bioluminescent reporter and the splicing changes observed in human leukocytes should allow for the more facile translation of novel splicing modulators into clinical application.
Synthesis of a biotinylated DNA probe to detect ribosomal RNA cistrons inProvidencia stuartii

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

A simple and convenient procedure that obviates the need for DNA cloning and radiolabelling is described for producing a rDNA hybridisation probe for use in bacterial strain characterisation. Bulk rRNA, comprising a mixture of 16S and 23S components, was isolated from Providencia stuartii NCTC11800 and purified by CsC1-cushion ultracentrifugation. The pure RNA was used as a template for synthesis of a single-strand copy cDNA using reverse transcriptase and random primers, with simultaneous biotin-11-dUTP labelling. EcoRI digests of chromosomal DNA from the type strain and a sample of 10 clinical isolates of P. stuartii were examined by Southern blot hybridisation on nylon membranes using the cDNA probe. All 11 strains had similar but not identical hybridisation patterns of 5–7 bands (detected colorimetrically) with sizes of about 5–19 kb. Our results indicated that the probe provided a sensitive means of detecting rRNA cistrons in P. stuartii. The method should be applicable to any group of microorganisms.
Characterization of Plastid 5-Aminolevulinate Dehydratase (ALAD; EC 4.2.1.24) from Spinach (Spinacia olevacea L.) by Sequencing and Comparison with Non-Plant ALAD Enzymes

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract We have sequenced 5-aminolevulinate dehydratase (ALAD; EC 2.4.1.24) of a plant. A fulllength cDNA clone (1727 bp) encoding this enzyme has been identified by immunoscreening a lambda gt 11 cDNA library of spinach. ALAD is not a plant-specific enzyme; however, the plant enzyme differs from the well known ALAD enzymes of bacteria, yeast and animals in structural and biochemical properties and in that it is located in the plastid. Differences and homologies can be traced back to the molecular level. The mature ALAD subunit, whose N-terminus was determined by automatic Edman degradation, is a protein of 367 amino acid residues and has a M r of 40,132. This figure is in the range of molecular weights of non-plant ALADs. The active centre is highly conserved and the same is true for the ion-binding domain, except that 4 cysteines of the non-plant enzymes (binding Zn 2+ ) have disappeared and a total of 6 aspartic acids meets the demands of Mg 2+ -binding. However, there are more distinct differences. Apart from a transit sequence of 56 amino acids targeting the plastid, the N-terminal part of the mature plant enzyme differs considerably from non-plant ALAD enzymes. It is rich in prolines and hydroxylated amino acids. The apparent M r on SDS-PAGE is 45,000 or higher, but up to now posttranslational modifications have not been found.
Implementing the balanced scorecard in excel for small and medium enterprises

Field: Business, Management and Accounting (Social Sciences)

Performance measurement is a way for organizations to be able to assess processes' performance. The Balanced Scorecard (BSC) is one of the best-known performance measurement systems. However, many small and medium enterprises (SME) face problems when trying to implement these frameworks, due to software associated costs. In this context, this paper documents the work conducted to develop a low cost solution for SME. The solution consisted on implementing the BSC in an excel workbook. The created tool allows users to have a chromatic view over data and assess its quality, by introducing risk analysis, through the utilization of trails with different intensities, depending on the associated risk. Moreover, data is automatically recorded to allow traceability and dynamic charts were introduced to allow the analysis of different performance attributes.
Present position concerning prevention of heart disease.

Field: Medicine (Health Sciences)

Recent advances in diagnostic skill and in the medical and surgical treatment of established cardiac lesions have over- shadowed the preventive approach to heart disease.The very large and increasing size of the total problem of vascular disease urges on us the need for active planning of its prevention.Prevention of further progression in those who already have developed heart disease is being achieved to a limited extent, but this must not be allowed to obscure the ultimate goal of primary prevention.The elaboration of certain specific primary preventive measures is already possible, and others should soon follow, despite the serious lack of knowledge of the mode of causation of most major forms of heart disease.The purpose of this article is to draw attention to the present possibilities of preventing heart disease in the several forms in which it occurs in Britain.Its compilation was stimulated by our attendance at a W.H.O.meeting on this subject held in Bucharest in March 1965, and attended by representatives from 25 European countries (W.H.O., 1965). Ischaemic Heart DiseaseWhile ischaemic heart disease is almost a daily clinical experi- ence for most doctors, not all are aware of the magnitude of the problem.In 1962 diseases of the coronary arteries and arteriosclerotic heart disease, together with so-called myocardial degeneration, were responsible for approximately half of all deaths in Britain.They accounted in men for 80% of deaths from circulatory diseases in England and Wales and a slightly higher proportion in Scotland, and in women for 60% of deaths from circulatory diseases in England and Wales and nearly 70% in Scotland.The mortality from ischaemic heart disease is greater in Scotland compared with England and Wales, and in 1961 the male mortality rate was the highest in the world and in excess even of the United States (415/100,000 population in Scotland compared with 376/100,(000 in United States) (W.H.O., 1964).Diseases of the coronary arteries are responsible for approxi- mately 30% of all deaths among middle-aged men and have been a steadily increasing cause of mortality for a number of years.This increase appears to be involving those under 45 years of age at a faster rate than older sections of the popula- tion (Table I).Improved diagnosis is unlikely to have contri- buted much to the increase, as diagnostic methods have not changed greatly between 1952 and 1962, and this table, which represents age-specific death rates, indicates that there are other explanations than that of an ageing population to account for this increase.Even if one subscribes to the view (Campbell, This paper contains our opinions only, and should not necessarily be interpreted as reflecting the views of other participants at the W.H.O.
Finite Element Analysis of Corroded Pipelines

Field: Engineering (Physical Sciences)

The objective of this project is to assess the integrity of corroded pipelines due to pitting type of corrosion defects. The scope of this project will be the finite element analysis of corroded pipelines on pitting type of corrosion defects and its modelling. This project was focused on the offshore pipeline. The type of pitting considered was on the single type of pitting. This project considered only the internal pressure as the loading. The software used to model the pipeline is CATIA and the software used to do the analysis is named ANSYS. The results of FE modelling were compared to the results of available codes used by the industries. The results from the available codes were referred as the empirical results. There were 2 codes used in this project namely DNV RP F101 and ASME B31G. As a result from this project, the integrity of corroded pipeline as well as prediction of remaining strength of corroded pipeline will be obtained. The successful outcome of this project will be a great helping guidance for industrial application towards assessing the integrity of corroded pipeline subjected to internal pressure only
Searching the essence of the Malaysian Constitution: between Islam and secular

Field: Social Sciences (Social Sciences)

This paper seeks to find the essence of the Malaysian constitution, between the Islamic and secular character of the constitution. The research examines the history and drafting of the constitution and studies the text of the Federal Constitution. The paper explores the meaning of secularism and secular state and compares the application of secular character in the constitution of some European countries. Several relevant case laws from Europe provide a comparative material in considering the extension of the same approach to Malaysia. The effect of such characterisation of a constitution and a country in the application of ordinary laws is considered.
Capitalization Rates, Discount Rates, and Net Operating Income: The Case of Downtown Chicago Office Buildings

Field: Economics, Econometrics and Finance (Social Sciences)

Executive Summary.The value of commercial real estate is its net operating income divided by the capitalization rate set by the buyer. This study examines both components of value. It also examines the close relationship between capitalization rates and risk-adjusted discount rates used in commercial real estate investment. The paper includes an empirical study of the capitalization rates for 132 office building sales in downtown Chicago from 1996 to 2007. The capitalization rate is hypothesized to be a function of the classic capital asset pricing model variables and variables intended to capture the expectation that the real market value of the building will change. The empirical results are then used to provide estimates of the real risk-adjusted discount rates that were used by the investors in these properties. The paper also includes estimates of a model of net operating income for these buildings.
The NBC Study and Television Violence

Field: Psychology (Social Sciences)

Journal Article The NBC Study and Television Violence Get access David A. Kenny David A. Kenny 1David A. Kenny is Professor of Psychology at the University of Connecticut Search for other works by this author on: Oxford Academic Google Scholar Journal of Communication, Volume 34, Issue 1, March 1984, Pages 176–182, https://doi.org/10.1111/j.1460-2466.1984.tb02995.x Published: 07 February 2006
Annotation of tertiary interactions in RNA structures reveals variations and correlations

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

RNA tertiary motifs play an important role in RNA folding and biochemical functions. To help interpret the complex organization of RNA tertiary interactions, we comprehensively analyze a data set of 54 high-resolution RNA crystal structures for motif occurrence and correlations. Specifically, we search seven recognized categories of RNA tertiary motifs (coaxial helix, A-minor, ribose zipper, pseudoknot, kissing hairpin, tRNA D-loop/T-loop, and tetraloop–tetraloop receptor) by various computer programs. For the nonredundant RNA data set, we find 613 RNA tertiary interactions, most of which occur in the 16S and 23S rRNAs. An analysis of these motifs reveals the diversity and variety of A-minor motif interactions and the various possible loop–loop receptor interactions that expand upon the tetraloop–tetraloop receptor. Correlations between motifs, such as pseudoknot or coaxial helix with A-minor, reveal higher-order patterns. These findings may ultimately help define tertiary structure restraints for RNA tertiary structure prediction. A complete annotation of the RNA diagrams for our data set is available at http://www.biomath.nyu.edu/motifs/ .