jimnoneill/paper-to-field-training huggingface dataset:
Anti-inflammatory effect of flavonoids from Comfort-G and the changes in arachidonic acid metabolism

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

SUMMARY Objective: Flavonoids from preparation Comfort-G have, beside of antioxidant effects, the anti-inflammatory effect, too. Comfort-G inhibits both COX-1 (cyclooxygenase-1)/COX-2 (cyclooxygenase-2) and 5-LO (5-lipoxygenase) enzymatic activity thereby decreasing the transformation of arachidonic acid (AA) to prostaglandins, thromboxanes, and leukotrienes. Our goal was to confirm this finding by the analysis of the content of AA in synovial fluid and serum of patients suffering by synovialitis of knee joint. Design: Interventional study. Settings: IV Department of Internal Medicine, Charles University in Prague, First Faculty of Medicine and General Teaching Hospital in Prague. Material and Methods: Comfort-G was given to the group of ten patients (4M/6F) aged 27–79 years in prescribed dose (equal to 250 mg of flavonoid extract twice a day) for one month. Synovial fluid and serum were drawn before first application of the preparation (day 0) and one day after the last application (day 31). Free radicals (FR) were determined by direct spectrophotometric method based on chlorophyllin reaction with FR; composition of fatty acids, including arachidonic acid, was measured by gas chromatography. The probands were also asked to respond to a questionnaire (subjective evaluation) and they were also examined by the physician. Following changes of knee joint were evaluated: swelling and degree of motion-angle. Statistical analysis was performed with the help of software STATISTICA for Windows, version 4.0. Results: The results showing the statistically significant decrease of free radical concentration in both synovial fluid and serum were presented and discussed in previously presented paper as well as the observed amelioration of patient stage. After the trial period, we found increased content of AA in both synovial fluid (4.54 ± 0.39 vs. 6.73 ± 0.82 mol%, p = 0.005) and serum (4.78 ± 0.90 vs. 6.57 ± 0.98 mol%, p = 0.01) in the same group of patients. Conclusion: Our results confirm that flavonoids from Comfort-G are able to decrease the amount of FR and increase the concentration of AA especially in synovial fluid, but also in serum of patients. This finding corresponds with the suggestion that the enzymatic transformations of AA resulting in production of pro-inflammatory compounds are blocked. The next consequences concerning other parts of organism and impact of our results in case of other diseases are discussed.
3. Diffractive Materialism: Karen Barad and the Performativity of Phenomena

Field: Arts and Humanities (Social Sciences)

This part focuses on Karen Barad’s agential realism. While the term seems contradictory at first sight, it refers to Barad’s interest in conceiving of materiality without subscribing to the idea of matter as a stable and solid fundament. I first present the different components of agential realism (epistemology, methodology, ontology, ethics) in sequence—acknowledging Barad’s claim that they cannot be separated or understood independently of one another. I also discuss the claim that agential realism contributes to a “new materialist understanding of power.” It focuses on Barad’s productive understanding of the “apparatus” that makes it possible to investigate how materializations are entangled with forms of exclusion and inequality, and analyzes how temporalities, spatialities, and materialities are mutually constituted. I will emphasize the distinctive theoretical and analytical strengths of agential realism (especially in comparison to OOO and vital materialism). However, the discussion also highlights some inconsistencies and problems that relate to the foundational role of quantum mechanics in Barad’s account and to the comprehensive concept of ethics she endorses.
Motion Control of Mobile Robot with the Switches of Traveling Direction and Control Gain

Field: Engineering (Physical Sciences)

In this study, the trajectory of a mobile robot is controlled by using a method based on the time state control form. It is possible to adjust the control parameters of this robot based on linear control theory. The distance to obstacles is measured by using a laser range finder. When the robot approaches to obstacles, the proposed controller switches the traveling direction and the control gain of the rotating motion. In the experiments, the robot avoided the obstacles and reached the target position, traveling back and forth automatically. Futhermore, the switching position and control parameters were searched by using a genetic algorithm. The parameters found by genetic algorithm made it possible for the robot to reach the target position in a short time.
Consider your companions carefully: How voters perceive (coalition) governments’ poor valence images?

Field: Social Sciences (Social Sciences)

Numerous studies of comparative political behavior examine how voters perceive parties’ ideological positions on various policy issues, either in a standard uni-dimensional space or on single issues. These studies assume these ideological positions to be representative of the entire governing coalition, classifying the government as a single unitary. While a common assumption when assessing coalition governments’ ideological positions, it is unclear whether this logic of shared accountability holds for voters’ perceptions of valence. To fill this gap, I use a conjoint experiment to assess the perceptual influence of valence issues on coalitional accountability. Overall, my results show that unlike standard left-right ideological positions, voters project the prime minister’s and (junior) cabinet members’ low valence bidirectionally onto each other. This research has implications for the prime minister’s selection process for (junior) cabinet members and junior parties’ own calculus of whether to participate in a coalition or not.
Global polymer nanocomposites market to exceed US$211 million by 2008

Field: Medicine (Health Sciences)

Clinical application of stem cell derivatives requires clinical-grade cells and sufficient preclinical proof of safety and efficacy, preferably in primates. We previously successfully established a clinical-grade human parthenogenetic embryonic stem cell (hPESC) line, but the suitability of its subtype-specific progenies for therapy is not clear. Here, we compared the function of clinical-grade hPESC-derived midbrain dopaminergic (DA) neurons in two canonical protocols in a primate Parkinson's disease (PD) model. We found that the grafts did not form tumors and produced variable but apparent behavioral improvement for at least 24 months in most monkeys in both groups. In addition, a slight DA increase in the striatum correlates with significant functional improvement. These results demonstrated that clinical-grade hPESCs can serve as a reliable source of cells for PD treatment. Our proof-of-concept findings provide preclinical data for China's first ESC-based phase I/IIa clinical study of PD (ClinicalTrials.gov number NCT03119636).
On coding precedence relations with a pair-ordering fidelity criterion (Corresp.)

Field: Computer Science (Physical Sciences)

In this correspondence, the rate-distortion function is calculated for a source emitting equiprobable precedence relations among m objects, using the fraction of pairs reproduced out-of-order as a distortion measure. For large m , the rate is approximately given by R(D) = m \log(1/D) . The rate-distortion characteristics of cluster coding is seen to be nearly ideal for low-distortion conditions.
FORMULATION AND OPTIMIZATION OF NANOSUSPENSION FOR IMPROVING SOLUBILITY AND DISSOLUTION OF GEMFIBROZIL

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Objective: The study aims at the formulation and optimization of gemfibrozil (Gem) nanosuspension (NS) for improving its solubility and dissolution rate.Method: Gem NS was prepared by precipitation-ultrasonication method using ethanol as solvent, water as anti-solvent, and polyvinyl alcohol (PVA) as a stabilizer. A Box–Behnken design was employed to study the effect of the independent variables, Gem concentration in the organic phase (X1), PVA concentration (X2) and sonication time (X3) on the dependent variable, drug release after 90 min (Y). The resulting data were statistically analyzed and subjected to 3D response surface methodology to study the influence of variables on the response. NS was evaluated for particle size, zeta potential, solubility and in vitro drug release and characterized using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffractometry (XRD).Results: On the basis of the evaluation, NS4 formulation (with 80 mg/ml Gem, 0.5% PVA concentration, and 20 min of sonication time) demonstrated highest drug content with a particle size of 191.0 nm and zeta potential of −12.0 mV. Dissolution profiles of NS indicated 2.5-fold increase in drug release than pure drug. NS demonstrated 5- and 9-fold increase in solubility, in water, and phosphate buffer (pH 7.5), respectively, pure drug. DSC and XRD studies indicated changes in the crystallinity of Gem during NS formulation. No chemical change was evident in NS as indicated by FTIR.Conclusion: Gem NS formulation could serve as a promising approach for improving its solubility and dissolution rate.
Some observations of zooplankton composition and abundance in river Damodar during winter season.

Field: Agricultural and Biological Sciences (Life Sciences)

The investigation has been made to examine the hydrological condition of the studied area (some physicochemical parameter of water, zooplankton community and its diversity).During the study it was observed that the trend of variation of water temperature was from 15.9ºc to17.5ºc. pH was found to alkaline ranging from 8.5 to 9.1.During the study there was afluctuation in O2levelfrom 3.2 mg/lit. to 5.2 mg/lit.Free CO2 was found to be higher throughoutthe study with a variation from 14 to 18 mg/lit.In the study of Zooplankton,Cladocera and Rotifera were chiefly present comprising mostly of Daphniasp, Rotariasp., Brachionussp.and Cyclopsspp. Besides theae groupsof speciesCopepoda was also present.A total of 10 genera includingone larval form were found during study. Among 10 genera only 5were dominant ( Daphniasp., Rotariasp., Brachionus sp., Mesocyclopssp.and nauplius larvae), within these dominant species the most dominant wereDaphniasp., Rotaria sp.and Brachionus sp.which occur more than three times during study.While the community study was concerned it was foundthatthe species richness ranged from 0.734 to 1.17, Evenness from 0.911 to 0.975and Shannon-Wiener index value was varied between 1.85 and 2.43. The mean values of them were0.924, 0.939and 2.25respectively.
The impact of concentrated growth factor and low-level laser therapy on osseointegration of dental implants: An experimental study on sheep

Field: Dentistry (Health Sciences)

This study aims to assess the effect of the Concentrated Growth Factor (CGF) with low-level laser therapy biostimulation (LLL) in the healing of bone around dental implants in an animal model. Four male sheep in good, healthy condition were utilized for the study. Sheep were divided into two groups, each model serving as two observation subgroups. The tibia of each sheep was subjected to random surgical procedures, with a one and two-month gap between each operation. A total of 40 dental implants were implanted, with each sheep receiving ten implants (five implants in each tibia). The groups were divided as follows: group 1 (Control), in which ten implants were placed in each sheep (five dental implants in each tibia), and group 2 (Study group in which ten implants were placed in each sheep (five dental implants in each tibia) with Sacco's Membrane (concentrated growth factor) and LLLT Biostimulation. Densitometric analysis was performed using digital radiography, immunohistochemical, and histopathological assessment. The findings of the present investigation revealed a statistically significant disparity in the extent of bone development surrounding dental implants at four and eight weeks, with the study group exhibiting a more favorable outcome than the control group. In conclusion, using CGF in conjunction with low-level laser treatment biostimulation has contributed to new bone formation and the establishment of osseointegration.
Adaptive Optics, LLLFT Interferometry, Astronomy

Field: Physics and Astronomy (Physical Sciences)

Abstract : We propose to build a three telescope Michelson optical interferometer equipped with wavefront compensation technology as a demonstration and test bed for high resolution Deep Space Surveillance (DSS) and Astronomy. Each telescope will have a liquid crystal (LC) Adaptive Optics (AO) phase retarder capable of providing diffraction or near diffraction limited operation. We will combine the wavefronts from the three telescopes using a conventional beam recombination system and acquire and track the fringes formed with a Low Light Level Fringe Tracking system (LLLFT). The telescopes, fringe tracker. a photon counting (Baker) camera, and LC devices and associated wavefront sensors are novel ideas currently under development at the USAF's Phillips Laboratory (PL) for DSS and theft combination should yield a state-of-the-art system equal or superior in performance to the best of the current generation of AO and Interferometric systems but for a few percent of the cost.
miR‑425‑5p is associated with poor prognosis in patients with breast cancer and promotes cancer cell progression by targeting PTEN

Field: Medicine (Health Sciences)

Breast cancer (BC) is the most common invasive cancer in women, and it imposes a heavy burden on patients. microRNAs (miRNAs/miRs) have been found to play an important role in the development of tumors, but their role in the malignant progression of BC is unclear. In the present study, the expression level of miR‑425‑5p was examined in patients with BC, and its association with prognosis was investigated. In vitro experiments were performed to examine role of miR‑425‑5p in the development of BC cells. A downstream target gene of miR‑425‑5p was predicted using a miRNA target prediction tool and validated with a luciferase reporter assay. It was found that miR‑425‑5p expression was increased in BC tissues and cell lines, and was associated with tumor size, clinical stage, lymph node metastasis, distant metastasis and poor overall survival in patients with BC. Knockdown of miR‑425‑5p in BC cell lines inhibited proliferation and migration. PTEN was identified as a downstream target gene of miR‑425‑5p. Overexpression of PTEN was demonstrated to partially inhibit the promotional effect of miR‑425‑5p on cell proliferation and migration. Taken together, miR‑425‑5p is associated with poor prognosis, and promotes cell proliferation and migration via PTEN. Thus, miR‑425‑5p may serve as a therapeutic and prognostic marker for BC.
“Harmony”:the core idea of tea culture

Field: Arts and Humanities (Social Sciences)

Based on ancient poetry and painting on aesthetic appreciation of tea,this paper illustrated idea that was core ideology of tea culture from four aspects,such as the ecological harmony of harmony of man and harmony among and the harmony of internal and external .The ecological harmony of meant that tea originated from nature,the harmony of man and symbolized that people melt with nature when tasting tea in natural condition,the harmony among appeared when people communicated with each other through lots of activities related with tea,the harmony of internal and external self formed when people pursuit highest realm of elusive ideal condition and oblivious of oneself.
The Verb in Contemporary English: Theory and Description

Field: Arts and Humanities (Social Sciences)

List of contributors Preface 1. Introduction: theoretical and descriptive approaches to the study of the verb in English Bas Aarts and Charles F. Meyer Part I. Theoretical Approaches to the Study of the English Verb: 2. Grammatical relations in English Charles F. Meyer 3. Competence without comp? Richard Hudson 4. On the semantics of the object I. M. Schlesinger 5. Secondary predicates in English Bas Aarts 6. The English perfect as a secondary past tense Rodney Huddleston 7.'How does this sentence interpret?' The semantics of English mediopassives Andrew Rosta 8. The expression of root and epistemic possibility in English Jennifer Coates Part II. Descriptive Approaches to the Study of the English Verb: 9. Find and want: a corpus-based case study in verb complementation Jan Aarts and Flor Aarts 10. Indeterminacy between noun phrases and adjective phrases as complements of the English verb Geoffrey Leech and Lu Li 11. Having a look at the expanded predicate John Algeo 12. 'This scheme is badly needed': some aspects of verb-adverb collocations Stig Johanssen 13. That and zero complementisers in late modern English: exploring ARCHER from 1650-1990 Edward Finegan and Douglas Biber 14. Changing patterns of complementation, and concomitant grammaticalisation, of the verb help in present-day British English Christian Mair 15. Verbs in public and private speaking Jan Svartvik and Olof Ekedahl 16. Some remarks on comment clauses Anna-Brita Stenstrom Index of names Subject index.
The isoscalar non-singlet axial form factor of the nucleon from lattice QCD

Field: Physics and Astronomy (Physical Sciences)

We present our progress on the computation of the axial form factor of the nucleon with flavour structure $u+d-2s$ from lattice QCD. We employ a set of $N_f=2+1$ CLS ensembles with $O(a)$-improved Wilson fermions and the Lüscher-Weisz gauge action, with lattice spacings ranging from $0.05\,\text{fm}$ to $0.086\,\text{fm}$ and pion masses spanning between $130\,\text{MeV}$ and $350\,\text{MeV}$. We employ multiple source-sink separations and use the summation method to suppress the contamination from excited states. We use a $z$-expansion on each ensemble to parametrize the $Q^2$-dependence of the form factor and simultaneously fit the available source-sink separations for all $Q^2\leq 0.7 \,{\rm GeV}^2$. We outline our analysis of the stability of the fits varying the ansätze and different estimations of the covariance matrix and report on our strategy for a comprehensive determination of the physical form factor.
Henry Hughes, First American Sociologist

Field: Social Sciences (Social Sciences)

Journal Article Henry Hughes, First American Sociologist Get access L. L. Bernard L. L. Bernard Washington University Search for other works by this author on: Oxford Academic Google Scholar Social Forces, Volume 15, Issue 2, December 1936, Pages 154–174, https://doi.org/10.2307/2570953 Published: 01 December 1936
Effect of Intensive Blood Pressure Control on Troponin and Natriuretic Peptide Levels: Findings From SPRINT

Field: Medicine (Health Sciences)

Background: Given the important role of cardiac injury and neurohormonal activation in the pathways leading from hypertension to heart failure and strong associations observed between hypertension and its sequelae on hs-cTnT (high-sensitivity cardiac troponin T) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels, we hypothesized that intensive systolic blood pressure (SBP) lowering would decrease levels of hs-cTnT and NT-proBNP. Methods: hs-cTnT and NT-proBNP were measured at baseline and 1 year from stored specimens in SPRINT (Systolic Blood Pressure Intervention Trial). Changes in biomarkers were evaluated continuously on the log scale and according to categories (≥50% increase, ≥50% decrease, or <50% change). The effect of intensive SBP lowering on continuous and categorical changes in biomarker levels were assessed using linear and multinomial logistic regression models, respectively. The association between changes in biomarkers on heart failure and death was assessed using multivariable-adjusted Cox proportional hazards models. Results: Randomization to intensive SBP lowering (versus standard SBP management) resulted in a 3% increase in hs-cTnT levels over 1-year follow-up (geometric mean ratio, 1.03 [95% CI, 1.01–1.04]) and a higher proportion of participants with ≥50% increase (odds ratio, 1.47 [95% CI, 1.13, 1.90]). In contrast, randomization to intensive SBP lowering led to a 10% decrease in NT-proBNP (geometric mean ratio, 0.90 [95% CI, 0.87–0.93]) and a lower probability of ≥50% increase in NT-proBNP (odds ratio, 0.57 [95% CI, 0.46–0.72]). The association of randomized treatment assignment on change in hs-cTnT was completely attenuated after accounting for changes in estimated glomerular filtration rate over follow-up, whereas the association of treatment with NT-proBNP was completely attenuated after adjusting for change in SBP. Increases in hs-cTnT and NT-proBNP from baseline to 1 year were associated with higher risk for heart failure and death, with no significant interactions by treatment assignment. Conclusions: Intensive SBP lowering increased hs-cTnT, mediated by the effect of SBP lowering on reduced kidney filtration. In contrast, intensive SBP lowering decreased NT-proBNP, a finding that was explained by the decrease in SBP. These findings highlight the importance of noncardiac factors influencing variation in cardiac biomarkers and raise questions about the potential role of hs-cTnT as a surrogate marker for heart failure or death in SBP-lowering studies.
The importance of nuclear spin diffusion as an angularly independent relaxation mechanism controlling the matrix ENDOR response of radicals in molecular crystals

Field: Chemistry (Physical Sciences)

In the generalized matrix ENDOR line shape model [P.A. Narayana et al., J. Chem. Phys., 67, 1990 (1977)] the ENDOR intensity is controlled by the nuclear spin lattice relaxation rate formulated as an angularly dependent electron-nuclear dipolar contribution and an angularly independent intrinsic bulk nuclear relaxation contribution. Comparison of this model with single crystal data [L. Kevan et al., J. Chem. Phys., 70, 5006 (1979)] showed that the angularly independent relaxation rate must be more rapid than the intrinsic bulk nuclear relaxation rate. Here we identify the angularly independent relaxation rate with nuclear spin diffusion and apply this interpretation quantitatively to data on methyl radicals in lithium acetate dihydrate crystals and to the radiation generated CH3CH(NH3)ĊOOH− radical in alanine at 77 K.
High Performance of Electrochemically Deposited NiCo2S4/CNT Composites on Nickel Foam in Flexible Asymmetric Supercapacitors

Field: Materials Science (Physical Sciences)

To exploit an efficient supercapacitor, improving the comprehensive properties of electrode materials has become an important goal. In this work, NiCo2S4 nanosheets were successfully combined with highly conductive carboxylated carbon nanotubes (CNT-h-COOH) by electrochemical deposition, forming an interconnected porous network of NiCo2S4 nanosheets/CNT composite on the nickel foam. The results showed that the deposition potential and time played important roles to influence the morphology and electrochemical performance of NiCo2S4 nanosheets/CNT composite. It turned out that the NiCo2S4/CNT composite prepared by depositing at a −0.9 V for 10 min presented excellent specific capacity at 1 A g–1 (2498.12 F g–1), outstanding rate characteristic at 100 A g–1 (compared with 1 A g–1, the capacitance retention was 61.1%), and exceptional cycle performance at 20 A g–1 (the capacitance retention rate after 10 000 charge/discharge cycles was 96.08%). Further, the flexible asymmetric supercapacitor (ASC) with a poly(vinyl alcohol) (PVA)/KOH gel electrolyte was obtained using commercial activated carbon as the anode and the NiCo2S4/CNT composite as the cathode. The ASC showed a high specific capacity of 215.06 F g–1 at 0.25 A g–1, an exceptional capacitance retention rate of 89.03% after 10 000 cycles, an outstanding energy density of 76.47 Wh kg–1 at 201.01 W kg–1, and excellent flexibility. Thereby, our study demonstrated that the electrodeposited porous NiCo2S4/CNT composite possesses a broad potential application in the area of supercapacitors.