jimnoneill/paper-to-field-training huggingface dataset:
Phase II trial of irinotecan plus bevacizumab for heavily pretreated recurrent ovarian cancer.

Field: Medicine (Health Sciences)

5016 Background: Irinotecan and bevacizumab have single agent activity in platinum sensitive (PSen) and resistant (PRes) ovarian cancer patients (pts). We sought to evaluate the efficacy and toxicity of irinotecan plus bevacizumab in these pts. The trial was designed to evaluate whether the progression free survival (PFS) at 6 months is at least 40% and with secondary objectives of estimating response rate (RR), duration of response (DoR), time to progression and toxicity. Methods: No limitation on number of prior regimens was placed, and prior use of study drugs was allowed. Irinotecan 250mg/m2 and bevacizumab 15mg/kg every 3 weeks were given. Due to treatment-related grade 3 toxicity (diarrhea and neutropenia) experienced by the first 5 pts on the study, the dose of irinotecan was amended to 175mg/m2. Results: 20 pts with recurrent ovarian cancer [PSen 5, PRes 15] of a planned 35 have been recruited thus far. Median age is 59 (45-78). Median number of prior regimens is 5 (3-12) with 9 pts demonstrating progressive disease (PD) on prior topotecan-containing regimens and 7 pts exhibiting PD on prior bevacizumab-containing regimens. 4 pts discontinued treatment before 2 cycles (2 for protocol defined toxicity, 2 by patient/physician choice). Partial response (PR) was observed in 2 PSen pts and 1 PRes pt, while stable disease (SD)was seen in 9 (2 PSen, 7 PRes) out of the 15 pts assessable for response at this time. 3 pts demonstrated PD after 2 cycles of treatment. 12 of 13 pts with PR or SD by RECIST also had response by CA125 criteria. Median DoR thus far (SD plus PR) is 18 weeks (4-37). 6 pts have ongoing response (4-18 weeks). Of 19 pts that received > 2 cycles, 3 had grade 3 diarrhea (2 before protocol amendment and 1 after). 2 pts had grade 3/4 neutropenia (1 before and 1 after protocol amendment). Median PFS is 9.6 months (mts). Median overall survival is 15.5 mts. PFS rate at 6 mts is 61% with 95% confidence interval: (40%, 92%). Conclusions: Results of the trial to date suggest the hypothesis that the PFS at 6 mts is less than 40% can be rejected. Activity of this regimen is encouraging given the heavily pretreated nature of the pts. Dose-limiting diarrhea and neutropenia required protocol amendment. We continue to accrue study subjects at the amended dosing.
Integrating Fuzzy Data Mining and Impulse Acoustic Techniques for Almond Nuts Sorting

Field: Agricultural and Biological Sciences (Life Sciences)

Sorting of agricultural products is one of the core research areas in the field of agricultural postharvest engineering. This paper presents an algorithm based method to sort four varieties of almond (Yalda, France, Shokofeh, and Shahrood 15) using impulse acoustic signals, selected features and rules generated from a decision tree, and fuzzy inference system. Two impact plates (Plywood and Stainless steel) and two fall heights (14 cm and 24 cm) were considered as test conditions. Results showed that the best decision tree will be obtained when impact plate is Stainless steel and fall height is 24 cm. In this condition, the fuzzy inference engine performance was found to be encouraging and its accuracy in the classification of almond varieties was 84.16%.
Mining Malware to Detect Variants

Field: Computer Science (Physical Sciences)

Cybercrime continues to be a growing challenge and malware is one of the most serious security threats on the Internet today which have been in existence from the very early days. Cyber criminals continue to develop and advance their malicious attacks. Unfortunately, existing techniques for detecting malware and analysing code samples are insufficient and have significant limitations. For example, most of malware detection studies focused only on detection and neglected the variants of the code. Investigating malware variants allows antivirus products and governments to more easily detect these new attacks, attribution, predict such or similar attacks in the future, and further analysis. The focus of this paper is performing similarity measures between different malware binaries for the same variant utilizing data mining concepts in conjunction with hashing algorithms. In this paper, we investigate and evaluate using the Trend Locality Sensitive Hashing (TLSH) algorithm to group binaries that belong to the same variant together, utilizing the k-NN algorithm. Two Zeus variants were tested, TSPY-ZBOT and MAL-ZBOT to address the effectiveness of the proposed approach. We compare TLSH to related hashing methods (SSDEEP, SDHASH and NILSIMSA) that are currently used for this purpose. Experimental evaluation demonstrates that our method can effectively detect variants of malware and resilient to common obfuscations used by cyber criminals. Our results show that TLSH and SDHASH provide the highest accuracy results in scoring an F-measure of 0.989 and 0.999 respectively. © 2014 IEEE.
Twenty years of Baltic Boreal coastal meadow restoration: has it been long enough?

Field: Environmental Science (Physical Sciences)

The restoration of a threatened type of seminatural grassland—the Baltic Boreal coastal meadows—began in Estonia in 1997. The main causes of degradation of these communities were land abandonment and overgrowth by reed. In 2015, we resurveyed 14 sites and classified as (1) permanently managed or (2) restored before 2005, or (3) after 2005. In 2015, all sites were managed under the EU agri‐environmental scheme and classified as permanently managed or restored before or after 2005. The resurvey focused on assessment of the long‐term success of restoration, comparing the vegetation parameters of restored meadows with permanently managed meadows (which were considered as reference). Our study revealed that historical management patterns have an impact on the species richness of these habitats, as more species were found in historically mown meadows, even if the sites were restored by grazing. However, species richness was not an important indicator of coastal meadow recovery. The best indicators of restoration success are evenness and coverage of low‐lying, light‐demanding, salt‐tolerant, wintergreen, cryptophyte, and hemicryptophyte plant species. Phragmites australis is a good indicator species for the habitat, as its abundance indicates poor habitat quality. The study indicated that the recovery of coastal meadow habitat from abandonment requires more than 15 years of restoration activities, and suggested the 3‐year restoration period covered by conservation measures and funds is not enough. Therefore, we recommend that agri‐environmental schemes should support additional restoration activities for recently restored meadows which are entering the management scheme.
Determination of Ethoxyquin in Feeds

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Revisions were made in the official, first action method for ethoxyquin in feeds which reduce the blank to the 0— 4 ppm range without reducing the recovery of the antioxidant by more than 5— 10%. Furthermore, the method also is applicable to feeds stored a reasonable length of time under moderate conditions. Blind samples can be spotchecked with a precision of 10— 12% over the range of ethoxyquin expected in feeds. The method can be refined to yield a precision of 2— 3%, if desired for use in production control, by preparing a calibration curve from data obtained by using the method to determine known amounts of ethoxyquin added gravimetrically to a standard feed.
Exploring polyamory online

Field: Social Sciences (Social Sciences)

This chapter explores how online interaction has the potential to provide both education and potential relationships for those interested in polyamory. It provides a basic introduction to polyamorous relationships and a largely descriptive explanation of how people can learn about polyamory online. Online support might be especially beneficial for someone who is new to polyamory or who might be questioning whether or not they have a poly identity. Soon, as Internet use increased and the number of polyamory-oriented print resources expanded, it became possible for more people than ever to learn that what they were doing was not necessarily unique or unusual; that a whole community of people were exploring polyamory. One of the key advantages of exploring polyamory online back then, as it is now, is the potential for privacy and comfort. The web is rich with resources for those who wish to explore polyamory, often written with care and passion by activists.
Support vector machine applied in the agriculture of Fanjing Mountain Areas

Field: Computer Science (Physical Sciences)

The method of Support Vector Machine (SVM) in Machine Learning (ML) has the advantages of complete theory, strong adaptability, global optimization, short training time and good generalization performance, which has become a hot topic in international and domestic research. Therefore, it is of great meaning to apply SVM to the modernization and intellectualization agriculture of Fanjing Mountain Areas of Tongren city, Guizhou province. This article introduces the basic situation of Fanjing Mountain Areas's agriculture in Section I. Section II and III expounds the method of kernel and four multi-class SVMs respectively. A practical application case about the shape classification problem of "clenched fist" in SVM is done in Section IV, and finally Section V concludes the full text.
Young children’s agency in their digital media use in the sociocultural contexts of homes: a case study from Finland

Field: Social Sciences (Social Sciences)

This socioculturally framed case study investigates the agency of young children aged 2 years old during their digital media use in their homes in Finland. The study has two objectives: (a) to portray children’s use of digital media in homes and (b) to identify how, if at all, children’s agency manifests itself in their digitally mediated activities in the home context. The case study data were collected by means of the “Day in the Life” methodology (Gillen, et al., 2007), which entails researchers visiting children’s homes and collecting observational and video data over one full day. The parents’ accounts were also taken into consideration by means of an informal interview. The findings demonstrate how the children’s agency manifested itself in child-initiated activities that afforded children to make choices, and to take active, interactive and creative positions around digital media. The children’s agency was mediated by the sociocultural contexts of their homes, including the nature of digital media at their disposal and the rules, objectives and social interactions between the child and adult(s). The study contributes to the present-day understanding of the sociocultural conditions of children’s agency and its manifestations in their digital media use at home.
Lobbyist Framing of Artificial Intelligence in Canada

Field: Social Sciences (Social Sciences)

Our research looks at the role lobbying plays in influencing artificial intelligence (AI) policy in Canada, especially during the agenda-setting and problem definition stages. Our research uses Critical Discourse Analysis (CDA) and policy agenda-setting theory to analyze federal parliamentary committee hearings and to uncover the underlying power dynamics of these stakeholder engagement venues. This research highlights a significant lack of representation of marginalized voices in this public forum, creating additional social exclusion for these groups in AI policymaking. As a result, policy recommendations stemming from these meetings did not properly account for AI-related risks felt by marginalized communities. Our findings show that lobbying groups use specific discursive strategies to further their self-interest, and that negativity bias strongly influences policymakers, prioritizing AI-related risks over benefits. Our findings contribute to the literature on social inclusion, lobbying, and AI governance. Thus, we emphasize the need for more equitable representation in AI policy discussions.
The Effects of Yacon (Smallanthus sonchifolius) Extract on Pancreatic Fibrosis in the Rat

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

야콘(Smallanthus sonchifolius)은 저혈당에 민간요법으로 이용해 오고 있는 구근작물이다. 최근에는 야콘잎이 항산화, 항균, 항진균 활성과 세포보호 기능이 있다고 보고되고 있다. 본 실험에서는 이러한 생리활성을 지니는 야콘잎을 이용하여 흰쥐에 DBTC (8 mg/kg)를 주사하여 췌장염을 유발시킨 후 1% 야콘추출물이 췌장의 섬유화에 미치는 영향을 연구하였다. 유발 21일째 처리군에서 췌장의 실질조직의 많은 부분이 collagen으로 재구성되어 있었으나 유발군에서는 처리군에 비해 현저히 감소되어 있었다. COX-2 발현에서, 대조군은 반응이 나타나지 않거나 매우 약한 반응이었으나, 유발군에서는 14일째 매우 증가되었으며, 특히 21일째는 침윤하고 있는 많은 염증세포에서 COX-2의 발현이 확인되었다. 처리군은 유발군에 비해 발현이 감소되었다. TGF-${\beta}1$ 발현은 21일째 염증세포에서는 유발군이 처리군에 비해 현저한 증가 현상이 나타났으나, 샘꽈리세포에서의 TGF-${\beta}1$의 발현은 처리군에서 증가되었다. VEGF 발현은 TGF-${\beta}1$의 발현과 거의 유사한 경향으로 나타났다. 그러므로 야콘추출물이 DBTC로 유도된 췌장염의 섬유화 진행을 억제하는데 매우 효과적임을 확인하였다. Yacon has been used in folk medicines as a medicinal tea for hypoglycemia treatment. In a recent study described herein, antioxidative, antibacterial, antifungal activities, and cell-protective functions of yacon leaves have been reported. To evaluate the effects on fibrosis on pancreatitis, the efficacy of 1% of yacon extract (YE) on dibutyltin dichloride (DBTC) (8 mg/kg)-induced pancreatitis in rats was examined. On the 21st day after the DBTC treatment, a large increase in collagen was observed in the pancreas in the DBTC-treatment group (DT). But this was noticeably decreased with YE. In relation to the expression of COX-2, there was no response or a very weak response in the pancreas of the control group (CON). However, in DT, strong expression of COX-2 was observed in the pancreas on the 14th day, and COX-2 was present in inflammatory cells in the pancreas of the DT, especially on the 21st day. The expression was decreased for YE compared with DT. A remarkable increase in TGF-${\beta}1$ expression was observed in inflammatory cells in the pancreas in DT on the 21st day, whereas the expression was not found in YE after 21 days. However, on the 21th day, TGF-${\beta}1$ expression was increased in acinar cells of YE compared with DT. VEGF expression was very similar to the expression of in the pancreas. These results suggest that YE has an inhibitory effect on DBTC-induced pancreatic fibrosis.
INFRARED AND RAMAN SPECTROSCOPIC STUDY OF SOME PERFLUOROMETHYL COMPOUNDS$^{\ast}$

Field: Chemistry (Physical Sciences)

$^{\ast}$Supported in part by a grant to Fisk University from the Research Corporation. $^{1}$ O. Thomas, Discussions of the Faraday Society 9:335, 339 (1950) $^{2}$ M. St. C. Flett, J. Chem. Soc. London, p. 962 (1951) $^{3}$ D. Hadzi and N. Sheppard. ``The Assignment of the infrared frequencies of the COOH group in carboxylic acid dimers,'' paper given at the International Meeting of Spectroscopists in Basel, Switzerland, June 28-30, 1951 $^{4}$ R. D. Cowan, G. Herzberg, and S. P. Sinha, J. Chem. Phys. 18:1538 (1950) $^{5}$ J. R. Nielson, N. H. Classen, and D. C. Smith, J. of Chem. Phys. 18:1471 (1950) $^{6}$ H. Schechter and F. Conrad, J. Am. Chem. Soc. 72:3371 (1950)
GW24-e0338 The effects of activation of autophagy on the neuron injury after return of spontaneous circulation from ventricular fibrillation in Wistar rats

Field: Neuroscience (Life Sciences)

Objectives To investigate the effects of activation of Autophagy on cerebral injury after cardiopulmonary resuscitation (CPR) in Wistar rat. Methods First 36 healthy adult male Wistar rats were induced ventricular fibrillation (VF) by alternating current for 7 minutes and then received CPR. Before VF (0) and at 1, 2, 4, 8 and 12 hours after return of spontaneous circulation (ROSC), cerebral cortex were harvested to determine the expressions of beclin-1 and LC3II by Weston blot. Further 60 healthy adult male Wistar rats were used to observe the effects of Autophagy activator Rapamycine (Rapamycine group, 20), Autophagy inhibitor 3-Methyladenine (3-MA group, 20) and Normal saline (Control group, 20) on the expressions of beclin-1, LC3II and the formation of autophagic vacuole in the cerebral cortex after ROSC. The neurologic deficit score (NDS) was used to evaluate the neurologic function at 24, 48 and 72h respectively after ROSC. The numbers of viable neurons and apoptotic neurons in the parietal cortex were counted by H&E staining and TUNEL staining after 72h. One-way ANOVA was used for the expressions of beclin-1 and LC3II and neurons counting. Rank sum test was used for NDS. Results The expressions of beclin-1 and LC3 II were significantly lower at 2 and 4h after ROSC than the levels before VF ( P < 0.05). The expressions of beclin-1 and the conversion of LC3 II in cerebral cortex at 2 and 4h after ROSC in the Rapamycine group were significantly higher than that in Control group and 3-MA group ( P < 0.05). The numbers of autophagic vacuole in the Rapamycine group at 2 and 4h after ROSC were significantly higher than the Control and 3-MA group. The number of viable neurons at 72h after ROSC in the Rapamycine group was 19 ± 516 ± 4/400pixs, higher than 16 ± 4/400pixs in Control group and 15 ± 3/400pixs in 3-MA group ( P < 0.05). The number of the TUNEL positive cells in the Rapamycine group was 12 ± 4/400pixs and was lower than 15 ± 6/400pixs in the Control group and 17 ± 5/400pixs in 3-MA group ( P < 0.05). The NDS scores of animals in Control group and 3-MA group at 24, 48 and 72h after ROSC were inferior to Rapamycine group. Conclusions The Autophagy of neurons in the cerebral cortex was attenuated in Wistar rats after ROSC. The activation of Autophagy can decrease the number of apoptotic neurons, preserve viable neurons and improve neurologic function.
Impact of COVID-19 Lockdown on Work-Life Balance of Australian Accountants

Field: Business, Management and Accounting (Social Sciences)

COVID-19 pandemic has brought unprecedented changes to office-based workers. This research investigates how the work-life balance was affected for Australian accountants with pre-school and primary school aged children whose work arrangements were impacted by COVID-19 pandemic lockdown. This research adopts inductive, qualitative research methods and six interviews were conducted with participants with different backgrounds as per Classical Grounded Theory (CGT) methodology to explore the changes in work life and family life of Australian accountants. A conceptual model emerged grounded in the findings from the interviews and triangulated data (as per CGT methodology) which demonstrates that work-life balance is a dynamic process where the physical change of work location forces the movement of boundaries between work and life, thus resulting in the redistribution of discretionary effort to re-balance work and life. This research is important because it explains how change of work arrangements poses an impact on work-life balance of professionals with pre-school and primary school aged children and has potential benefits of enhancing office workers’ wellbeing. Options for future research and limitations are also discussed.
OSO-7 Observations of Circinus X-1

Field: Physics and Astronomy (Physical Sciences)

view Abstract Citations (10) References (7) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS OSO-7 Observations of Circinus X-1 Canizares, C. R. ; Li, F. K. ; Clark, G. W. Abstract We present data from six observations with the MIT X-ray detectors on the 0S0-7. The results for one 5d interval rule out the 12 d.288 binary eclipse period proposed by Jones, Tananbaum, and Giacconi for this source. The average spectrum is considerably steeper than those of the established eclipsing binaries. Subject headings: binaries - X-ray sources Publication: The Astrophysical Journal Pub Date: July 1974 DOI: 10.1086/181552 Bibcode: 1974ApJ...191L..75C full text sources ADS |
A Study on the Transfer Planning in a Freight Terminal : The Effect of Passage Width on the Transferring Velocity

Field: Engineering (Physical Sciences)

For the transfer planning in a freight terminal, passage width is one of the main factors. Although three passage widths are important for transferring by a truck, there are very few reports about right-angled passage width. So the experiment is carried out mainly on the right-angled passage width by using a forklift-truck and a hand-truck. The summary of the results is shown below. 1. It is possible to arrange the experiment data of "delay time" by the intersection area without regard to inlet or outlet passage width. Here, "delay time" is defined as the difference time between the time to pass right-angled corner and the time to go straight the same distance on the same width passage. 2. It becomes possible to estimate the delay time from the truck velocity on straight passage and the product of the length and breadth of a truck.
Communication barriers in maternity care - a questionnaire study among migrants to Norway

Field: Health Professions (Health Sciences)

Abstract Background Sub-optimal maternity care among migrants has been reported in a number of European countries. Explanations are multifactorial; however, communication barriers have been suggested as a major factor. Our aim was to explore recent migrant women's reported need for interpreter, actual interpreter use and the understanding of information provided during maternity care in Norway. Methods As part of the multidisciplinary, mixed method MiPreg-project, we applied a quantitative questionnaire, using a modified version of Migrant Friendly Maternity Care Questionnaire. We included recently (≤ 5 years) migrated women born in low or middle-income countries giving birth in urban Oslo, Norway, during 2019. Face-to-face interviews in women's own language of choice were conducted postpartum. Results We included 401 women from 65 countries. The five most frequent languages spoken at home were English, Polish, Arabic, Urdu and Tigrinya. The Norwegian proficiency was low; 23% not at all, 39% with difficulty, 39% good. Two thirds of women would have understood the information during maternity care better in another language. Two out of five felt a need for interpreting services and of these 44% and 81% were not offered interpreter during pregnancy and birth, respectively. The woman's partner or other adult family member interpreted most frequently, followed by professional interpreter and healthcare professionals. The women themselves often felt they understood the information provided; 78% always, 20% sometimes and 2% rarely/never. Increased length of residency and higher education was associated with better understanding, also after adjusting for maternal age and immigrant status. Discussions Several communication barriers exist for recent migrant women, with possible consequences for quality of maternity care. Recommended standards for interpretation services were not followed. To address barriers, increased use of interpreter and multilingual antenatal courses could be effective. Key messages Low language proficiency and use of interpreter may contribute to disparities in maternity care for migrants. The unmet needs for interpretation services must be addressed with appropriate actions.
Geometric Concerns for Accurate Measurement of Capillary Pressure Relationships With Centrifuge Methods

Field: Earth and Planetary Sciences (Physical Sciences)

Summary Accuracy of capillary pressure relationships obtained from centrifuge experiments is widely recognized to depend on the quality of raw data, the homogeneity of the rock sample, and the methods used for data reduction. However, the systematic error caused by the radial nature of centrifugal fields is not widely recognized. This paper shows that this radial error can be greater than errors caused by poor data-reduction methods. The radial error can be estimated from the geometry of centrifuge rotors and rock sample dimensions. Careful experimental technique can minimize radial error. Furthermore, data-reduction methods can eliminate radial error by properly accounting for the radial nature of centrifugal fields.