jimnoneill/paper-to-field-training huggingface dataset:
Parental Response to Lovaas Treatment of Childhood Autism.

Field: Psychology (Social Sciences)

This study examined the importance of several parental factors in shaping the outcome of a behavioral treatment program for children with autism based on the work of O. Ivar Lovaas. The Lovaas approach remediates behavior problems through the redesign of the household environment. Respondents to a questionnaire sent to 18 families were 3 mothers and 2 fathers from a total of 5 families of children (ages 4-7) with autism. Specifically, the study looked at the following factors: (1) amount of time each family spent delivering the therapeutic interventions; (2) the number of different therapists per family; (3) optimistic or pessimistic attitudes about therapy; and (4) the structure of the family. Results suggested that the female parent generally experiences greater stress and responsibility in caring for an autistic child. Male parents spent significantly less time with the autistic child but tended to be more generally optimistic about their child's future than did mothers. Both male and female parents were somewhat optimistic about the Lovaas method. The average family used five therapists and devoted a mean number of 5.5 hours daily to therapy. (DB) ***********************************w*********************************** Reproductions supplied by EDRS are the best that can be made from the original document. *********************************************************************** U.S. DEPARTMENT OF EDUCATION Office of Educational Research and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) 04.1:-IS document has been reproduced as recetved from the person or organtzation originating tt O Minor changes have been made to improve reproduction Quality Points ot wew or opintons slated tn this dOcument do not necessardy represent official OEM posihon or poltcy Parental Response to Lovaas Treatment of Childhood Autism Catherine Chambliss, Ph. D. Renee J. Doughty Ursinus College
Evidence that a 27-residue sequence is the actin-binding site of ABP-120

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Proteolysis experiments of ABP-120 from Dictyostelium discoideum have previously demonstrated that removal of residues 89-115 from a tryptic peptide which retains actin binding activity, abolishes actin binding (Bresnick, A. R., Warren, V., and Condeelis, J. (1990) J. Biol. Chem. 265, 9236-9240). Antibodies made against a synthetic peptide of this 27-amino acid sequence (27-mer) specifically immunoprecipitate native ABP-120 from Dictyostelium high speed supernatants, demonstrating that the 27-mer sequence is on the surface of the molecule as expected for an active site. ABP-120 is inhibited in its binding to F-actin by Fab' fragments of the anti-27-mer IgG. Half-maximal inhibition occurs at an approximate molar ratio of 7 Fab' fragments/ABP-120 monomer. Viscoelastic measurements indicate that ABP-120 forms fewer cross-links with F-actin in the presence of the 27-mer synthetic peptide than in its absence. In F-actin cosedimentation assays, the binding of ABP-120 to actin is inhibited by the 27-mer synthetic peptide. Furthermore, the 27-mer synthetic peptide cosediments with F-actin, whereas a control hydrophobic peptide and a synthetic peptide of residues 69-88 of ABP-120 do not cosediment with F-actin. These observations suggest a direct involvement of the 27-mer sequence in the actin binding activity of ABP-120.
Motor imagery based BCI classification via sparse representation of EEG signals

Field: Computer Science (Physical Sciences)

Electroencephalogram (EEG) based brain-computer interface (BCI) provides a new communication and control channel for people with severe motor disabilities. Motor imagery based sensorimotor rhythm (SMR) analysis is one of the widely used methods in the BCI field. However, these motor imagery signals are very noisy and strongly depends on subjects. Therefore, it is difficult to classify them and thus more powerful classification methods are needed. In this paper, we propose a new classification method based on sparse representation of EEG signals and ell-1 minimization. Using Mu and/or Beta rhythm as EEG features, we evaluate the performance of the proposed method with four data sets. Moreover, we make performance comparison with the linear discriminant analysis (LDA), another classification method. From the results, our proposed method shows the better classification accuracy.
Microbial Conversion of (+)-Limonene by an Enterobacter agglomerans Isolate

Field: Immunology and Microbiology (Life Sciences)

Enterobacter agglomerans 6L was isolated from citron (Citrus junos) peel by using an enrichment culture containing (+)-limonene. It was able to metabolize limonene and grew well (A 600 : 4.5) on limonene as a sole carbon source. E. agglomerans 6L was highly resistant to limonene toxicity, and grew to 1.0 optical density (A 600 ) even at 5% (v/v) of limonene in Luria-Bertani media. γ-Valerolactone and cryptone were detected as the major metabolic products of limonene by E. agglomerans 6L.
Exploiting the process capability of profile tolerance according GD&#x00026;T ASME-Y14.5M

Field: Engineering (Physical Sciences)

GD&T language allows us to control part geometric variations from a designer’s point of view. The tolerances should also take into account the effect of available fabrication, assembly, and inspection processes. This study proposes new mathematical models for identification and calculation of the profile tolerance according to ASME Y14.5(.1)M-1994 considering the available process capability and the geometric complexity of a part. The models are based on the order statistic theorem. From these models, charts were constructed to ease the calculation of the tolerance by the designer. Finally, two case studies are presented to illustrate the usefulness of the developed models.
In-Capillary Derivatization and Stacking Electrophoretic Analysis of γ-Aminobutyric Acid and Alanine in Tea Samples To Redeem the Detection after Dilution To Decrease Matrix Interference

Field: Chemistry (Physical Sciences)

An in-capillary derivatization and stacking capillary electrophoresis (CE) technique has been applied to redeem the detection of dilute analytes in the analysis of gamma-aminobutyric acid (GABA) and alanine (Ala) in tea samples. Extracts from samples were diluted to eliminate matrix interference before introduction into the CE system. GABA and Ala in the diluted sample zone were derivatized with o-phthaldialdehyde/2-mercaptoethanol (OPA/2-ME) to form fluorescence-labeled products in the stacking process, and the labeled derivatives were then enriched by online stacking. Optimal conditions for the stacking, such as the concentration of the background buffer solution, the matrix of the sample zone (sample solution), and the volume of the sample injection, were investigated and then applied to real sample analysis. Under optimum conditions, the detections were linear in the range of 5.0 nM-2.5 microM with the square of correlation coefficients (R2) of 0.9995 and 0.9992 for GABA and Ala, respectively. Detection limits were found to be 0.7 and 0.8 nM for GABA and Ala, respectively. Tea samples were analyzed with recoveries between 92.33 and 97.87% and between 94.36 and 96.46% for GABA and Ala, respectively. This method is a rapid, convenient, and sensitive process for determining GABA and Ala in complicated matrix samples such as tea samples.
Effects of <i>N</i>‑Alkyl-4-Methylamphetamine\nOptical Isomers on Plasma Membrane Monoamine Transporters and Abuse-Related\nBehavior

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

4-Methylamphetamine (4-MA) is an\nemerging drug of abuse that acts as a substrate at plasma membrane\ntransporters for dopamine (DAT), norepinephrine (NET), and serotonin\n(SERT), thereby causing nonexocytotic release of monoamine transmitters\nvia reverse transport. Prior studies by us showed that increasing\nthe <i>N</i>-alkyl chain length of N-substituted 4-MA analogues\nconverts 4-MA from a transportable substrate (i.e., releaser) at DAT\nand NET to a nontransported blocker at these sites. Here, we studied\nthe effects of the individual optical isomers of <i>N</i>-methyl-, <i>N</i>-ethyl-, and <i>N</i>-<i>n</i>-propyl 4-MA on monoamine transporters and abuse-related\nbehavior in rats because action/function might be related to stereochemistry.\nUptake inhibition and release assays were conducted in rat brain synaptosomes\nwhereas electrophysiological assessments of drug–transporter\ninteractions were examined using cell-based biosensors. Intracranial-self-stimulation\nin rats was employed to assess abuse potential in vivo. The experimental\nevidence demonstrates that <i>S</i>(+)<i>N</i>-methyl 4-MA is a potent and efficacious releaser at DAT, NET, and\nSERT with the highest abuse potential among the test drugs, whereas <i>R</i>(−)<i>N</i>-methyl 4-MA is a less potent\nreleaser with reduced abuse potential. The <i>S</i>(+)­ethyl\nanalogue has decreased efficacy as a releaser at DAT but retains full\nrelease activity at NET and SERT with a reduction in abuse-related\neffects; the <i>R</i>(−)­ethyl analogue has a similar\nprofile but is less potent. <i>S</i>(+)<i>N</i>-Propyl 4-MA is a nontransported blocker at DAT and NET but an efficacious\nreleaser at SERT, whereas the <i>R</i> enantiomer is almost\ninactive. In conclusion, the <i>S</i> enantiomers of the <i>N</i>-alkyl 4-MA analogues are most potent. Lengthening the <i>N</i>-alkyl chain converts compounds from potent nonselective\nreleasers showing abuse-related effects to more selective SERT releasers\nwith no apparent abuse potential.
The effect of environmental on spontaneous activities and expression of c-Fos, 5-HT in the hippocampal neurons of rats with posttraumatic stress disorder

Field: Neuroscience (Life Sciences)

Objective
To investigate the expressions of c-Fos, 5-HT and spontaneous activities in single prolonged stress(SPS) stress rats , and to study the possible mechanism of posttraumatic stress disorder(PTSD).

Methods
forty-eight male SD rats were randomly divided into 6 groups: Individual living+ SPS group (IS group), Individual living+ control group (IC group), Enriched environment+ SPS group (ES group), Enriched environment+ control group (EC group), control+ SPS group(CS group), control group(C group), 8 rats in each group, spontaneous activities were measured before the experiment and post experiment at week 1, 2. And the expressions of c-Fos, 5-HT in the hippocampus were examined by immunohistochemical staining.

Results
(1)Spontaneous activity: there were no differences of crossing number and distance among 6 groups before experiment(P>0.05). On SPS 14 days the crossing number and distance of IS group (12.12±9.64, (2.71±1.99)m) decreased compared with the CS group(45.25±8.37, (6.37±1.18)m, P<0.05), and ES group (69.75±10.05, (10.69±1.50)m) showed significant increase compared with CS group (P <0.05). (2)5-HT: the expression of 5-HT in the hippocampus of IS group(0.1125±0.0095) was significantly higher than that in CS group(0.6138±0.0059, P<0.05), menwhile lower in ES group(0.0495±0.0074, P<0.05). (3)c-Fos: compared with CS group(0.3108±0.0074), the expression of c-Fos in the hippocampus of IS group(0.3585±0.0150, P<0.05) significantly increased, but decreased in ES group(0.2613±0.0063, P<0.05).

Conclusion
Enriched environmental can improve the level of activities in PTSD rats, and to reduce the the expression of c-Fos and 5-HT in the hippocampal neurons.

Key words:
Posttraumatic stress disorder; Single prolonged stress; Enriched environment; Individual living; c-Fos; 5-hydroxytryptamine
Taking Stock of Trade Policy Uncertainty: Evidence from China’s Pre-WTO Accession

Field: Economics, Econometrics and Finance (Social Sciences)

We study the effects on international trade from the annual tariff uncertainty about China's MFN status renewal in the U.S. prior to joining the WTO.We have four main findings.First, in the monthly data trade increases significantly in anticipation of uncertain future increases in tariffs and falls upon renewal.Second, the probability of a tariff increase was perceived to be relatively small, with an average annual probability of non-renewal of about 3.2 percent.Third, what matters more is the expected future tariff rather than the uncertainty around it.We identify these effects using within-year variation in the risk of trade policy changes around the renewal vote and trade flows.We show that an (s; s) inventory model generates this behavior and that variation in the strength of the stockpiling in advance of the vote is increasing in the storability of goods.Fourth, the costs associated with the trade policy induced stockpiling reduce entrants' incentive to operate in a market with tariff uncertainty.Our results explain why trade may hold up in advance of a prospective policy change, such as Brexit or the U.S.-China escalating tariff war of 2018-19, but may fall sharply even if expected tariff increases do not materialize.
Metallogenetic and Ore-controlling Factors,Distribution and Enrichment Regularities of Iron and Copper Ore Belt I in Dahongshan Copper Deposit

Field: Earth and Planetary Sciences (Physical Sciences)

Basesd on the previous study on the geology of the Dahongshan copper deposit,and the collected geological information,the recognized geological characteristics of the deposit in the process of capital construction and mining production,according to new metallogenetic theory,the metallogenetic and orecontrolling factors,the distribution and enrichment regularities of iron and copper ore belt I of Dahongshan Copper deposit has been studied comprehensively,and the enrichment regularities of main orebody Ⅰ_3 and Ⅰ_2 has been put forward,hereby the geological basis is provided for the production and developing plan of Dahongshan Copper mine in the future.
Investigating Entrepreneurship Competencies Among University Students: A Descriptive-Comparative Study

Field: Business, Management and Accounting (Social Sciences)

This descriptive-comparative study examined the self-perceived entrepreneurship competencies of 282 university students across four core domains defined by the entrepreneurship competence framework: ideas and opportunities, personal resources, specific knowledge, and into action. Utilizing both descriptive statistics and inferential analyses (t-tests and Welch’s ANOVA), the study revealed that students generally reported moderately high levels of entrepreneurial competence, particularly in opportunity recognition, resilience, and adaptability. Notably, female students scored significantly higher in the personal resources domain, highlighting a gender-based strength in intrapersonal and interpersonal capacities. Furthermore, significant differences in specific knowledge and overall entrepreneurship competence emerged across household income groups, with students from higher economic backgrounds exhibiting stronger domain-specific knowledge, affirming the influence of socioeconomic status on entrepreneurial development. These findings were interpreted through the theoretical lenses of the Theory of Planned Behavior, Human Capital Theory, and Effectuation Theory. The results suggest that attitudes and perceived behavioral control influence competence perceptions, economic resources shape access to knowledge, and adaptive learning fosters entrepreneurial resilience. Practical implications underscore the need for equity-oriented interventions that scaffold entrepreneurial skills, especially for economically disadvantaged students. This study contributes to the growing literature on entrepreneurship education by offering empirical insights into competence disparities and by proposing inclusive pedagogical strategies.
Supplementary Table 3 from Mapping of the <i>IRF8</i> Gene Identifies a 3′UTR Variant Associated with Risk of Chronic Lymphocytic Leukemia but not Other Common Non-Hodgkin Lymphoma Subtypes

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>PDF file - 47K, Association of MCL risk with IRF8 sequencing and tagged SNPs located on 16q24</p>
Functional cross-talk between cytokine receptors revealed by activating mutations in the extracellular domain of the β-subunit of the GM-CSF receptor

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Several reports have suggested an interaction between the erythropoietin receptor (EpoR) and the shared signaling subunit (hβc) of the human granulocyte macrophage-colony stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5 receptors, although the functional consequences of this interaction are unclear. We previously showed that in vivo expression of constitutively active extracellular (EC) mutants of hβc induces erythrocytosis and Epo independence of erythroid colony-forming units (CFU-E). This occurs despite an apparent requirement of these mutants for the GM-CSF receptor α-subunit (GMRα), which is not expressed in CFU-E. Here, we show that coexpression of hβc EC mutants and EpoR in BaF-B03 cells, which lack GMRα, results in factor-independent proliferation and JAK2 activation. Mutant receptors that cannot activate JAK2 fail to produce a functional interaction. As there is no detectable phosphorylation of hβc on intracellular tyrosine residues, EpoR displays constitutive tyrosine phosphorylation. These observations suggest that JAK2 activation mediates cross-talk between EC mutants of hβc and EpoR. The implications of these data are discussed as are our findings that activated hβc mutants can functionally interact with certain other cytokine receptors.
On the Micro-Dynamics of a Cash-in-Advance Economy

Field: Economics, Econometrics and Finance (Social Sciences)

The purpose of this paper is to develop a general equilibrium model with money and trade taking place outside of equilibrium. There are multiple markets which are visited sequentially by the agents and transactions occur at disequilibrium prices along the adjustment path. This implies quantity rationing and we assume that there is a cash-in-advance constraint which limits the agents' ability to transact. The updating of the prices and cash balances makes it necessary for agents to re-optimize their trading plans subject to new information due to substitution and spill-over effects. The dynamics of this disequilibrium price and quantity process are shown to depend crucially on the exchange mechanisms that are imposed. One of the results is that the introduction of a cash-in-advance constraint, although it prevents debts from occurring outside of equilibrium, does not stabilize endogenous fluctuations.
Correspondence to

Field: Medicine (Health Sciences)

2 Background—Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a hereditary form of amyloidosis characterized by sensorimotor and autonomic neuropathy, cardiac conduction defects and infiltrative cardiomyopathy. Previous studies have suggested that myocardial sympathetic denervation assessed by 123-iodine metaiodobenzylguanidine (MIBG) imaging occurs early in disease progression. However, its prognostic significance was never evaluated. We aimed to study the long-term prognostic value of myocardial sympathetic denervation detected by MIBG imaging in TTR-FAP. Methods and Results—A total of 143 individuals with V30M TTR mutation underwent Holter, ambulatory blood pressure monitoring, echocardiography and MIBG imaging. Time to all-cause death was compared with late heart-to-mediastinum MIBG uptake ratio (H/M)
Indications for Laparoscopic Antireflux Procedures in Children

Field: Medicine (Health Sciences)

The decision for antireflux surgery is often made on an individual basis. How symptom patterns and therapeutic suggestions relate is debatable. There is a long list of differential diagnoses for vomiting not caused by disturbances of the lower esophageal sphincter. Guidelines for the clinical practice in gastroesophageal reflux have been established for children and for adult patients by the Genval Workshop Report and the Trondheim Consensus statement. Endoscopy is indicated if macroscopically visible lesions are to be expected. Routine endoscopic biopsy is not used in the diagnosis of gastroesophageal reflux disease (GERD). pH monitoring is performed in 33 to 77% of patients. If the most prominent symptoms are respiratory, radiographic studies and pH monitoring prove that the symptoms are really related to GERD. Best results with drugs are achieved by effective initial therapy. The effects of long-term treatment are little known. Failed long-term therapy, complications of esophagitis, recurrent aspiration, apnea or "near miss" sudden infant death syndrome, failure to thrive and anatomical abnormalities are indications for surgery. The superiority of laparoscopic antireflux surgery over open surgery depends on the experience of the surgeon. Some surgeons choose a "tailored approach", ie, perform a partial wrap in children with normal peristalsis, an extrashort "floppy" Nissen or a partial wrap for those with impaired peristalsis, and a slightly tighter 360-degree wrap in neurologically impaired children. Partial wraps allow vomiting, which is considered risky in neurologically impaired children.
Project Delivery Selection Matrix for Highway Design and Construction

Field: Decision Sciences (Social Sciences)

Determining an appropriate delivery method for highway projects is a complex process. This paper presents a decision support approach to assist highway agencies in evaluating and selecting the most suitable delivery method for their projects. The approach uses a matrix to consider three fundamental delivery methods currently in use by the highway industry: design–bid–build, design–build, and construction manager–general contractor. The approach, which is in use by the Colorado Department of Transportation (DOT), includes four primary selection factors (delivery schedule, complexity and innovation, level of design, and initial project risk assessment) and four secondary selection factors (cost, staff experience and availability, level of oversight and control, and competition and contractor experience) in the delivery decision. These eight selection factors, along with opportunities and challenges for each delivery method, were identified through a literature search and were tested by discussions and workshops with innovative contracting leaders from the Colorado DOT, FHWA, the American Council of Engineering Companies, Associated General Contractors of America, and the University of Colorado. The approach enables an initial risk assessment to occur early in the project development process and before the project delivery decision. The project delivery selection matrix promotes a better understanding of project goals, risks, and opportunities and enhances alignment among project participants. The approach has been successfully tested and implemented through eight projects of varying scope throughout Colorado. This paper presents the project delivery selection matrix along with an illustrative case study to demonstrate the results. The research provides a defensible and repeatable process for highway agencies to select an appropriate delivery method for their projects.
Highly Ordered Mesoporous Tungsten Oxides with a Large Pore Size and Crystalline Framework for H2S Sensing

Field: Materials Science (Physical Sciences)

Abstract An ordered mesoporous WO 3 material with a highly crystalline framework was synthesized by using amphiphilic poly(ethylene oxide)‐ b ‐polystyrene (PEO‐ b ‐PS) diblock copolymers as a structure‐directing agent through a solvent‐evaporation‐induced self‐assembly method combined with a simple template‐carbonization strategy. The obtained mesoporous WO 3 materials have a large uniform mesopore size (ca. 10.9 nm) and a high surface area (ca. 121 m 2 g −1 ). The mesoporous WO 3 ‐based H 2 S gas sensor shows an excellent performance for H 2 S sensing at low concentration (0.25 ppm) with fast response (2 s) and recovery (38 s). The high mesoporosity and continuous crystalline framework are responsible for the excellent performance in H 2 S sensing.