jimnoneill/paper-to-field-training huggingface dataset:
Two stage sequential procedure for nonparametric regression estimation

Field: Mathematics (Physical Sciences)

In nonparametric statistics the functional form of the relationship between the response variable and its associated predictor variables is unspecified but it is assumed to be a smooth function. We develop a procedure for constructing a fixed width confidence interval for the predicted value at a specified point of the independent variable. The optimal sample size for constructing this interval is obtained using a two stage sequential procedure which relies on some asymptotic properties of the Nadaraya--Watson and local linear estimators. Finally, a large scale simulation study demonstrates the applicability of the developed procedure for small and moderate sample sizes. The procedure developed here should find wide applicability since many practical problems which arise in industry involve estimating an unknown function. References E. F. Schuster. Joint asymptotic distribution of the estimated regression function at a finite number of distinct points. Ann. Math. Statist., 43, 1972, 84--88. http://www.jstor.org/stable/2239900 E. Isogai. The convergence rate of fixed-width sequential confidence intervals for a probability density function. Seq. Anal., 6, 1987, 55--69. doi:10.1081/SQA-100102647 E. A. Nadaraya. On estimating regression. Theory of Probab. Appl., 9, 1964, 141--142. doi:10.1137/1109020 M. P. Wand and M. C. Jones. Kernel Smoothing. Chapman and Hall, London, 1995. G. S. Watson. Smooth regression analysis. Sankhya Series A, 26, 1964, 359--372. W. S. Cleveland. Robust locally weighted regression and smoothing scatterplots. J. Amer. Statist. Assoc., 74, 1979, 829--836. http://www.jstor.org/stable/2286407 J. Fan and I. Gijbels. Local Polynomial Modelling and its Applications. Chapman and Hall, London, 1996. T. Gasser, L. Sroka and C. Jennen-Steinmetz. Residual variance and residual pattern in nonlinear regression. Biometrika, 73, 1986, 625--633. http://www.jstor.org/stable/2336527 M. Ghosh, N. Mukhopadhyay and P. K. Sen. Sequential Estimation. Wiley, New York, 1997.
Relationship Between Outbreaks of Saddled Prominent, Heterocampa guttivitta (Lepidoptera: Notodontidae), and Drought

Field: Agricultural and Biological Sciences (Life Sciences)

Journal Article Relationship Between Outbreaks of Saddled Prominent, Heterocampa guttivitta (Lepidoptera: Notodontidae), and Drought Get access Peter J. Martinat, Peter J. Martinat 1 Department of Environmental and Forest Biology, College of Environmental Science and Forestry, State University of New York, Syracuse, New York 13210 1Current address: Div. of Forestry, West Virginia Univ., Morgantown, WV 26506-6125. Search for other works by this author on: Oxford Academic PubMed Google Scholar Douglas C. Allen Douglas C. Allen Department of Environmental and Forest Biology, College of Environmental Science and Forestry, State University of New York, Syracuse, New York 13210 Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 16, Issue 1, 1 February 1987, Pages 246–249, https://doi.org/10.1093/ee/16.1.246 Published: 01 February 1987 Article history Received: 27 May 1986 Accepted: 07 November 1986 Published: 01 February 1987
Power consumption with distance-adaptive load balancing in flexible bandwidth optical networks

Field: Engineering (Physical Sciences)

In this paper, we propose a distance-adaptive load balancing algorithm to improve spectrum efficiency and to reduce power consumption in flexible bandwidth optical networks. Simulation results show that our proposed DALB algorithm significantly reduces blocking probability but consumes more power consumption compared to the traditional Dijkstra algorithm under the 40 Gbps, 100 Gbps, and mixed line rates, respectively. We should trade off between spectrum efficiency and power consumption when we consider distance-adaptive load balancing.
Urticaria caused by Arcanobacterium haemolyticum: Diagnostic and therapeutic failures

Field: Medicine (Health Sciences)

We presented a case of seventeen-year-old girl exhibiting mild symptoms of sore throat, a marked urticarial rash and heavy desquamations of the skin on palms and soles. According to the antibiogram and diagnosis of Streptococcus non A non B group obtained in routine laboratory procedure, the patient was treated with penicillin; however, ineffectively. Escalation of urticaria and failure of the initial penicillin therapy shifted the diagnosis towards exanthema toxoalergicum and thus to treatment with corticosteroids and antihistamines, yet with no improvement. The culture was repeated with a new specimen. Diagnosis was made according to the specific pattern in a double CAMP test, and confirmed by the ApiCoryne diagnostic set (BioMerieux). With respect to cultural traits, the isolate mimicked Streptococcus pyogenes, yet developing specific pattern in a double CAMP test that directed our diagnosis towards coryneform microorganisms. The diagnosis of Arcanobacterium haemolyticum was confirmed with 99.9% probability rate and T = 0.75.
Serological and infection statuses of dogs from a visceral leishmaniasis-endemic area

Field: Veterinary (Health Sciences)

OBJECTIVE This study investigated the serological status of dogs living in a visceral leishmaniasis-endemic area and its correlation with the parasitological condition of the animals.METHODS Canine humoral response was evaluated using the sera of 134 dogs by enzyme-linked immunosorbent assay and immunohistochemistry to detect parasites in the skin, lymph node, and spleen of the animals. The specific antibodies investigated were IgG, IgG1, IgG2, and IgE.RESULTS According to the parasitological, laboratory, and clinical findings, the dogs were placed into one of four groups: asymptomatic with (AP+, n = 21) or without (AP-, n = 36) Leishmania tissue parasitism and symptomatic with (SP+, n = 52) or without (SP-, n = 25) parasitism. Higher IgG and IgE levels were positively correlated with the infection condition and parasite load, but not with the clinical status. In all groups, total IgG was the predominant antibody, which occurred at the expense of IgG2 instead of IgG1. Most of the infected dogs tested positive for IgG (SP+, 98.1%; AP+, 95.2%), whereas this was not observed with IgE (SP+, 80.8%; AP+, 71.2%). The most relevant finding was the high positivity of the uninfected dogs for Leishmania-specific IgG (SP-, 60.0%; AP-, 44.4%), IgE (SP-, 44.0%; AP-, 27.8%), IgG1 (SP-, 28.0%; AP-, 22.2%), and IgG2 antibodies (SP-, 56.0%; AP-, 41.7%).CONCLUSIONS The serological status of dogs, as determined by any class or subclass of antibodies, did not accurately distinguish dogs infected with L. (L.) infantum chagasifrom uninfected animals. The inaccuracy of the serological result may impair not only the diagnosis, but also epidemiological investigations and strategies for visceral leishmaniasis control. This complex serological scenario occurring in a visceral leishmaniasis-endemic area highlights the challenges associated with canine diagnosis and points out the difficulties experienced by veterinary clinicians and coordinators of control programs.
DenudatinA, a neolignan fromMagnolia soulangiana

Field: Chemistry (Physical Sciences)

In the title compound, (2S,3R,3aR)-2-(1,3-benzodioxol-5-yl)-3,3a-di­hydro-3a-methoxy-3-methyl-5-(2-propenyl)-6(2H)-ben­zo­furan­one, C20H20O5, the furan ring has a half-chair conformation with its O atom on the twist axis. The semi­quinone ring is slightly non-planar, with a maximum deviation of 0.065 (3) Å.
Some surface tension and contact angle problems in industry

Field: Chemistry (Physical Sciences)

Contact angle, surface tension and wetting properties are of fundamental importance in many industrial processes, e.g. coating of television screens and fluorescent lights. In addition, different stages of many processes may involve immersion cleansing and subsequent drying. We consider two different problems: one being very practical and involving cleansing and drying of silicon substrates in the semiconductor industry, and the other being theoretical whereby the problem of the shape of scssile and pendant drops is addressed with a possible practical application for making contact angle and surface tension measurements. In the case of cleansing of silicon substrates, we model a process whereby dirt particles are removed as a result of the surface tension forces exerted on a particle passing through a water/air interface and give a possible explanation as to why the efficiency of the process is vclocity dependent. For the case of small liquid drops, a new formulation of the governing equation yields solutions for multiple pendant and extended sessile drops.
Bubnov-Galerkin method for the Elastic Stress Analysis of Rectangular Plates under Uniaxial Parabolic Distributed Edge Loads

Field: Engineering (Physical Sciences)

Electrical energy is indispensable in people's lives for the sake of survival and for life on the work.Society is now very dependent on electric energy because without the existence of electrical energy the community activity will be stalled.The loads used in electric energy operations vary widely.Electrical energy operations are severely disrupted due to unbalanced load and nonlinear loads.Unbalanced load and nonlinear loads used for the operation of electrical energy can be disturbing because they produce non-pure sinusoidal waves.THD_i (harmonics) caused by the unbalance of load and nonlinear load have an impact on electric energy losses and heat on the transformer.THD_i (harmonics) is caused by unbalance of load and nonlinear load Between Phases RN equal to 7.87%, at SN equal to 3.22%, and at TN 2,41%.After the Passive Filter design is installed THD_i between Phases becomes smaller that is at RN becomes 1.82%, SN becomes 0.82%, and in TN becomes 0.57%.THD_i (harmonics) between phases can be decreased by 76% after Passive Filter is installed.Desain Passive filters are very effective at reducing THD_i (harmonics) in buildings such as laboratories that use the load of imbalances and nonlinear loads for lab.
John arber and Mark Harrison, eds., The Soviet Defence-Industry Complex from Stalin to Khrushchev. New York: St.Martin's Press, 2000. 283 pp. $79.95.

Field: Social Sciences (Social Sciences)

September 01 2001 The Soviet Defence-Industry Complex from Stalin to Khrushchev. Johnarber and MarkHarrison, eds., The Soviet Defence-Industry Complex from Stalin to Khrushchev.New York: St.Martin's Press, 2000. 283 pp. $79.95. Joseph S. Berliner Joseph S. Berliner Brandeis University Search for other works by this author on: This Site Google Scholar Author and Article Information Joseph S. Berliner Brandeis University Online Issn: 1531-3298 Print Issn: 1520-3972 © 2001 by the President and Fellows of Harvard College and the Massachusetts Institute of Technology2001 Journal of Cold War Studies (2001) 3 (3): 112–113. https://doi.org/10.1162/jcws.2001.3.3.112 Cite Icon Cite Permissions Share Icon Share Twitter LinkedIn Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation Joseph S. Berliner; The Soviet Defence-Industry Complex from Stalin to Khrushchev.. Journal of Cold War Studies 2001; 3 (3): 112–113. doi: https://doi.org/10.1162/jcws.2001.3.3.112 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsJournal of Cold War Studies Search Advanced Search This content is only available as a PDF. © 2001 by the President and Fellows of Harvard College and the Massachusetts Institute of Technology2001 Article PDF first page preview Close Modal You do not currently have access to this content.
Carnitine supplementation in progressive supranuclear palsy

Field: Medicine (Health Sciences)

Abstract Mitochondrial dysfunction has been implicated in the pathogenesis of several neurodegenerative disorders, including progressive supranuclear palsy (PSP). PSP is a Parkinsonian syndrome characterized by a rapidly progressive state that manifests itself as tremors, bradykinesia, and supranuclear gaze palsy. Carnitine plays an essential role in mitochondrial function by transporting fatty acids across the mitochondrial membrane to be used in energy production. Mitochondrial dysfunction can bring about rapid neuronal depolarization and a calcium‐mediated cellular apoptosis owing to a loss of oxidative metabolism, likely contributing to the PSP disease process. A White man aged 65 years with PSP presented with small bowel obstruction and severe malnutrition as a result of prior gastrointestinal surgeries for which a gastrostomy tube was placed. During his hospitalization, the patient was found to be deficient in both free and total carnitine. He was treated with levocarnitine supplementation and exhibited marked improvement in tremors, fatigue, and physical therapy activities. Posthospitalization follow‐up showed sustained improvement in symptoms with continued levocarnitine supplementation. Treatment of PSP remains largely supportive in nature. No studies have investigated the role of carnitine supplementation in PSP. To our knowledge, this is the first case report to identify improvement in PSP symptoms after carnitine repletion and supportive care. Numerous animal studies have reported on carnitine supplementation in the context of mitochondrial dysfunction associated with neurodegenerative diseases, such as Parkinson disease and Alzheimer disease. Further investigation is necessary to elucidate the precise role of carnitine and other nutrition supplements in the pathophysiology of PSP.
CONSERVATION AND EXPLOITATION OF BANG GRASS EFFECTIVE IN PHU MY VILLAGE, VIETNAM

Field: Environmental Science (Physical Sciences)

Phu My located in Kien Giang province, South of Vietnam is a small village with the majority of the population made of a Khmer community.The weather conditions are not encouraging for locals due to serious flooding months.The soils and water are comparatively acidic.Therefore, only Bang grass (Lepironia articulate)an indicator for the wetland habitats and Nang grass (Eleocharis dulcis.)themain food of an endangered Sarus Crane (Grus antigone) can thrive.Bang grassland area decreased due to the housing problem.To overcome the decrease of Bang grass and conserve this species, the project "Restoration and sustainable exploitation Bang grassland in Phu My, 2004" conducted to help locals make sophisticated handmade products from Bang grass.It is a good way to help the locals to benefit and conserve Bang grass.
Effect of impaired autophagic flux on breast carcinogenesis through the enhanced LC3-p62-NRF2 feedback loop.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

6 Background: Breast cancer affects more women worldwide than any other type of cancer. Although some genes have been identified as potential causes, the exact molecular mechanism of the disease is still unknown. In our study, we aimed to investigate the role of NRF2 and the autophagy markers p62 and LC3 in breast cancer cell lines that have different Tp53 status using a new compound called 6,6'dihydroxythiobinupharidine (DTBN). In our previous research, we have shown that DTBN modulates key cellular signal transduction pathways that are relevant to disease biology, including cancer. Furthermore, we analyzed online databases to determine the correlation between NRF2, p62, LC3, and Tp53 in breast cancer patients. Methods: To evaluate the effect of DTBN on NRF2, p62 and LC3 in different types of breast cancer cell lines with varying TP53 status, we conducted molecular studies by inhibiting NRF2 activity. We synthesized the correlation between NRF2, p62, LC3 and TP53 expression and clinical parameters by analyzing TCGA and GEO datasets. Results: Our findings suggest that DTBN induces cell death and autophagy in all breast cancer cell lines, regardless of their Tp53 status. However, they also led us to hypothesize that NRF2 may hinder the sensitivity of cancer cells to DTBN-induced cell death and autophagy. To test this hypothesis, we inhibited NRF2 activity using an NRF2 inhibitor called brusatol. The results of the study indicate that the inhibition of NRF2 significantly increased cell death and autophagy in DTBN-treated cells. We observed a decrease in the expression of the autophagy marker p62, while an increase in the expression of another autophagy marker LC3. These findings suggest that the interaction between NRF2, LC3 and p62, which is activated in response to DTBN treatment, may serve as a potential anticancer drug target. We have validated the positive correlation between NRF2 and the autophagic gene p62 and LC3, in different Tp53 status breast cancer cell lines by analyzing TCGA and GEO data. Conclusions: Our study shows that high levels of Nrf2, LC3 and p62 expression are significantly associated with increased breast cancer cell proliferation and migration. This implies that patients with breast cancer have lower overall survival and a higher rate of recurrence. Our findings highlight the role of DTBN-induced NRF2 and LC3 expression and reduced p62 expression in breast cancer cells with varying Tp53 status. These results may represent a paradigm for better understanding the cancer cell response to therapies and designing more efficient combined anticancer therapies targeting NRF2, LC3 p62, and Tp53.
The New Intermediary on the Block: Funding Portals under the CROWDFUND Act

Field: Economics, Econometrics and Finance (Social Sciences)

The CROWDFUND Act, part of the JOBS Act signed into law in the United States in April 2012, provides for a new registered securities intermediary known as a funding portal. Funding portals or registered brokers must participate in crowdfunded offerings of securities conducted in accordance with the new federal offering registration exemption created in the CROWDFUND Act. Although regulations are forthcoming that will further illuminate the structure and function of funding portals, the CROWDFUND Act itself offers some insights into the role of funding portals in securities crowdfunding and allows for preliminary observations about legal issues inherent in funding portal status. This paper makes those observations and highlights areas of potential regulatory concern after labeling funding portals using existing terminology and locating funding portals in recognized taxonomies of securities intermediaries.
Lower limb motor function and hip muscle weakness in stroke survivors and their relationship with pelvic tilt, weight-bearing asymmetry, and gait speed: A cross-sectional study

Field: Medicine (Health Sciences)

Background: Poor motor recovery of hip muscles affect the walking post-stroke. The study objective was to examine how lower extremity motor function and hip muscle weakness are related to weightbearing asymmetry (WBA), excessive pelvic tilt, and gait speed in stroke survivors. Methods: Eighty patients with chronic stroke, a mean and standard deviation (SD) of post-stroke duration of 350 ± 664 days, age of 30-70 years, independent standing, and 10-meter walking capacity participated in the study. Hip muscular strength was measured using a handheld dynamometer (HHD) and motor function was assessed by Fugl-Meyer Assessment of lower extremity (FMA-LE). The WBA was recorded using two weighing scales; whereas the pelvic tilt and gait speed were evaluated using palpation meter (PALM) and 10-meter walk test, respectively. Results: The muscles strength of hip flexors, extensors, abductors, and adductors of the paretic side ranged between 22.0 and 24.4 pounds. The mean score of FMA-LE was 22 points. Following Pearson product-moment correlation with statistically significant P < 0.05, the relationship of hip muscles strength and FMA with WBA, lateral pelvic tilt (LPT) and anterior pelvic tilt (APT), and speed are as follows: flexors (r = 0.47, r = 0.31, r = 0.44, r = 0.44), extensors (r = 0.45, r = 0.38, r = 0.37, r = 0.35), abductors (r = 0.49, r = 0.32, r = 0.38, r= 0.40), adductors (r = 0.45, r = 0.31, r = 0.23, r = 0.34), and motor function (r = 0.62, r = 0.33, r = 0.38, r = 0.62).
Gastroduodenal ulceration associated with flunixin meglumine administration in three dogs

Field: Veterinary (Health Sciences)

In 3 clinically ill dogs, signs of gastroduodenal ulceration were first noticed within 7 days of beginning flunixin meglumine administration and included pyrexia, anorexia, weight loss, vomiting, melena, pain on abdominal palpation, and abdominal distention. One dog was euthanatized and 2 dogs recovered after surgical repair of the perforated ulcers and treatment of peritonitis. Prolonged administration of flunixin meglumine should be avoided, especially in debilitated dogs or when concurrently administering other nonsteroidal anti-inflammatory drugs or corticosteroids.
[Castleman's angiofollicular lymphoma as a cause of anemia and splenomegaly with indications for splenectomy].

Field: Medicine (Health Sciences)

The physiology of the spleen is very complex and has a series of factors, which request a more detailed explanation. With different blood diseases, namely, the reticulo endothelium system the spleen more or less, plays the central part in the general pathological events. Indication for splenectomy requests many internal, haemotologic, immunologic examinations and a close cooperation with the surgeon. The failure of a performed splenectomy is seldom related, directly to the surgical techniques, more frequent with a bad ante operationem assessment, namely predictable assessory spleen, which continues to play the splenogenous disfunction. Such a "clinical misunderstanding" we had in the case presented in the paper. We spoke of our experiences with a patient who suffered from anaemia and an enormous enlargement of the spleen. After the splenectomy anaemia, unfortunately, was persistent. During the operation we found a tomefact (as big as a nut) located on the right side, paravertebral in peritoneum. The probatory cutting off was sent to the pathologist, we asked for a verification. We were warned by the pathologist to extract in toto. Only in that way the mentioned symptoms might disappear, the existing anaemia, too.
Treatment of the cervical lymph nodes and significance of sentinel lymph nodes in early stage oral cancer

Field: Medicine (Health Sciences)

我々の施設で臨床的に転移を認めない早期口腔癌40症例について原発巣の切除のみを行い頸部は経過観察を行った。後発転移が22.5％で発生していた。 一部の施設ではラジオアイソトープを用いたセンチネルリンパ節（SN）同定法・生検法が導入されている。頭頸部癌におけるSN生検術は欧米では既に標準治療として位置付けられている。我が国ではようやく頭頸部癌診療ガイドライン2018年版で記載されるに留まっている。 我々は，1）超音波造影剤ソナゾイドを用いたSN同定法，と，2）超音波の新技術Superb Microvascular Imagingによる微小血流評価によるSN転移判定法を考案し，第I相試験を実施している。この一連の方法が確立すれば，超音波機器さえあれば「SNの同定」から「SNにおける転移の有無の判定」まで，一般の外来で安全・確実にしかも安価で頸部郭清術の適応の有無を決めることが可能となる。