jimnoneill/paper-to-field-training huggingface dataset:
The development of Newton’s law encyclopedia based on advance organizer

Field: Arts and Humanities (Social Sciences)

This research aims to develop Newton's Law encyclopedias based on Advance Organizer, that is suitable for use as a source of learning. The method used in this research is Research and Development (R&D) using ADDIE model. The steps of ADDIE model are analyze, develop, implement, and evaluate. The research instrument was obtained from interviews, observation, and questionnaires. The encyclopedia cover is designed to illustrate the content of the material on this product. The title of each content is arranged alphabetically in Bahasa. The content of the encyclopedia consists of (1) dinamometer, (2) force, (3) weight, (4) frictional force, (5) normal force, (6) centripetal force, (7) tension force, (8) Newton's First Law, (9) Newton's Second Law, (10) Newton's Third Law, (11) gravitional force, (12) Kepler's Law, (13) gravity accelaration. Finally, the structure of this encyclopedia is structured based on steps in Advance Organizer model, there are presentaion of Advance Organizer, presentation of learning task, and strengthening cognitive organization. This encyclopedia expected to be feasible of use as a learning resource for textbook companion in senior high school based on validated by experts.
In-vitro investigation of very long defibrillation shocks: Design and testing of a capacitor-free defibrillator

Field: Engineering (Physical Sciences)

The aim of this paper is to describe a defibrillator that allows the delivery of arbitrary waveform shocks, with energy up to 10J and duration up to 100 ms. In addition, data from shocks delivered to isolated rabbitpsilas hearts are presented. The solutions adopted in the design and realization of the defibrillator were: rechargeable battery power; linear AB class power amplifier output in bridge configuration; optical isolation of analog and digital lines to and from the PC and earth ground; measure of the actual voltage, current and energy delivered to the load. Laboratory testing showed that the defibrillator is capable to deliver shocks with a rising time less than 150 us, no tilting also for very long waveforms (100 ms), peak current up to 10 A. The system was then used on rabbit hearts to define a protocol to investigate the effect of waveform duration on defibrillation threshold. We demonstrate the feasibility of an experimental defibrillator for the generation and delivery of true arbitrary waveforms.
LPS-stimulated activation of microglial cells with increasing iba1-immunoreactivity in culture.

Field: Neuroscience (Life Sciences)

<p>The iba1-positive cells are shown in N9 cells (A) and BV2 cells (B) with DAPI counterstaining after LPS exposure of 12h-48h. Density in mean fluorescence intensity (MFI) of iba1-immunoreactivity among different N9 and BV2 cell groups is compared (C), ANOVA: * <0.05, ** <0.01 <i>vs</i> control.</p>
Customer online shopping experience data analytics

Field: Decision Sciences (Social Sciences)

Purpose The purpose of this paper is to develop a customer online behaviour analysis tool, segment high-value customers, analyse their online purchasing behaviour and predict their next purchases from an online air travel corporation. Design/methodology/approach An operations review of the customer online shopping process of an online travel agency (OTA) is conducted. A customer online shopping behaviour analysis tool is developed. The tool integrates competitors’ pricing data mining, customer segmentation and predictive analysis. The impacts of competitors’ price changes on customer purchasing decisions regarding the OTA’s products are evaluated. The integrated model for mining pricing data, identifying potential customers and predicting their next purchases helps the OTA recommend tailored product packages to its individual customers with reference to their travel patterns. Findings In the customer segmentation analysis, 110,840 customers are identified and segmented based on their purchasing behaviour. The relationship between the purchasing behaviour in an OTA and the price changes of different OTAs are analysed. There is a significant relationship between the flight duration time and the purchase lead time. The next travel destinations of segmented high-value customers are predicted with reference to their travel patterns and the significance of the relationships between destination pairs. Practical implications The developed model contributes to pricing evaluation, customer segmentation and package customization for online customers. Originality/value This study provides novel method and insights into customer behaviour towards OTAs through an integrated model of customer segmentation, customer behaviour and prediction analysis.
Elevated Heterozygosity in Adults Relative to Juveniles Provides Evidence of Viability Selection on Eagles and Falcons

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Viability selection yields adult populations that are more genetically variable than those of juveniles, producing a positive correlation between heterozygosity and survival. Viability selection could be the result of decreased heterozygosity across many loci in inbred individuals and a subsequent decrease in survivorship resulting from the expression of the deleterious alleles. Alternatively, locus-specific differences in genetic variability between adults and juveniles may be driven by forms of balancing selection, including heterozygote advantage, frequency-dependent selection, or selection across temporal and spatial scales. We use a pooled-sequencing approach to compare genome-wide and locus-specific genetic variability between 74 golden eagle (Aquila chrysaetos), 62 imperial eagle (Aquila heliaca), and 69 prairie falcon (Falco mexicanus) juveniles and adults. Although genome-wide genetic variability is comparable between juvenile and adult golden eagles and prairie falcons, imperial eagle adults are significantly more heterozygous than juveniles. This evidence of viability selection may stem from a relatively smaller imperial eagle effective population size and potentially greater genetic load. We additionally identify ~2000 single-nucleotide polymorphisms across the 3 species with extreme differences in heterozygosity between juveniles and adults. Many of these markers are associated with genes implicated in immune function or olfaction. These loci represent potential targets for studies of how heterozygote advantage, frequency-dependent selection, and selection over spatial and temporal scales influence survivorship in avian species. Overall, our genome-wide data extend previous studies that used allozyme or microsatellite markers and indicate that viability selection may be a more common evolutionary phenomenon than often appreciated.
Faster identification of waterborne threat.

Field: Health Professions (Health Sciences)

The need to quickly identify and take remedial action against bacterial contamination within a hospital environment is essential for patient safety. Guidelines for the monitoring of Pseudomonas aeruginosa within hospital water systems are laid down in the HTM 04-01 Addendum, but many hospitals test more regularly as part of a water safety plan. Here, Andrew Headland, senior business manager for IDEXX Water, explains how a new testing method is allowing facility managers to detect Pseudomonas in hospital water more quickly, and deal with consequent contamination more effectively, ultimately helping to save lives.
ChemInform Abstract: Bioinorganic Chemistry of Pterin‐Containing Molybdenum and Tungsten Enzymes.

Field: Chemistry (Physical Sciences)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Enhancing plant photosynthesis with dual light conversion films incorporating biomass-derived carbon dots

Field: Agricultural and Biological Sciences (Life Sciences)

Enhancing photosynthesis is a pivotal strategy for achieving sustainable plant production. Blue and red light facilitate plant growth since these wavelengths are readily absorbed by chlorophyll pigments and power crucial photosynthetic processes. In this investigation, double light conversion films were prepared by incorporating biomass-derived carbon dots into a polyvinyl alcohol matrix (CDs@PVAs). The study conclusively demonstrated that CDs@PVAs can convert ultraviolet and green light from sunlight into blue and red light. Using 2-week-old Athaliana plants as the model organism, the Athaliana plants were covered with CDs@PVAs and then exposed to simulated sunlight (0.57 mW cm−2) for 1 hour. The Fv/Fm value in the presence of the CDs@PVAs was approximately 12% higher than without the film, indicating a significant boost in photosynthesis. Analysis of gene expression showed that the CDs@PVAs cause significant upregulation of genes associated with photosynthesis. These double light conversion films thus emerge as promising contenders for eco-friendly plant cultivation methods that circumvent reliance on electric power. Their potential applications in agriculture are substantial, underscoring their significance in promoting sustainable practices.
Association between obesity with disease-free survival and overall survival in triple-negative breast cancer

Field: Medicine (Health Sciences)

OBJECTIVE: To investigate the relationship between obesity and disease-free survival (DFS) and overall survival (OS) of triple-negative breast cancer. METHODS: Citations were searched in PubMed, Cochrane Library, and Web of Science. Random effect model meta-analysis was conducted by using Revman software version 5.0, and publication bias was evaluated by creating Egger regression with STATA software version 12. RESULTS: Nine studies (4412 patients) were included for DFS meta-analysis, 8 studies (4392 patients) include for OS meta-analysis. There were no statistical significances between obesity with DFS (P = .60) and OS (P = .71) in triple-negative breast cancer (TNBC) patients. CONCLUSION: Obesity has no impact on DFS and OS in patients with TNBC.
The impact of bystander cardiopulmonary resuscitation on patients with out-of-hospital cardiac arrests

Field: Medicine (Health Sciences)

Out-of-hospital cardiac arrest (OHCA) is one of the leading causes of death around the world. Bystander cardiopulmonary resuscitation (CPR) is an independent factor to improve OHCA survival. However, the prevalence of bystander CPR remains low worldwide. Community interventions such as mandatory school CPR training or targeting CPR training to family members of high-risk cardiac patients are possible strategies to improve bystander CPR rate. Real-time feedback, hands-on practice with a manikin, and metronome assistance may increase the quality of CPR. Dispatcher-assistance and compression-only CPR for untrained bystanders have shown to increase bystander CPR rate and increase survival to hospital discharge. After return of spontaneous circulation, targeted temperature management should be performed to improve neurological function. This review focuses on the impact of bystander CPR on clinical outcomes and strategies to optimize the prevalence and quality of bystander CPR.
A Physical/Chemical System for Water and Atmosphere Recovery Aboard a Space Station

Field: Engineering (Physical Sciences)

<div class="htmlview paragraph">The paper deals with the problems of development of physico-chemical systems for water recovery and atmosphere revitalization for long-duration space stations. Schematics of regenerative life support systems featuring a high degree of closure and biotechnological components are presented. A year-long experiment has proved the possibility for Man to stay in a closed artificial environment for a long time by consuming substances regenerated by physico-chemical means from the end products of life. A complex of the life support systems (LSS) on Mir space station allowing for oxygen and 90% water recovery as well as its future updating is considered.</div>
Multidimensional ontology-based visual ranking

Field: Computer Science (Physical Sciences)

Evangelia Triperina obtained her PhD in Computer Sciences from the University of Limoges, France in 2020. Her thesis focuses on the interdisciplinary research in multidimensional decisions support in the ranking problematic aided by visual analytics and semantic web technologies. Interactive visual analytics exploit the increased visual perceptual abilities of the decision makers creating a more efficient decision support procedure, while semantic web technologies, and more specifically ontologies, structure data, make the system dynamic and add several needed capabilities to the decision support system. Furthermore, the multidimensional decision support method relies not only on evaluating an alternative based on multiple criteria, but also on important dimensions of the domain 1 .
Application of fuzzy mathematical comprehensive evaluation in optimization of new formula of buckwheat tea

Field: Agricultural and Biological Sciences (Life Sciences)

Because the existing buckwheat tea products was single and its flavor or function nutrition ingredient was poor,Zi Juan tea,llex kudingcha and Angelica keiskei extract were choosed to intensify the buckwheat tea products by spray and used fuzzy mathematical comprehensive evaluation to screen three new formulation of buckwheat tea.Results showed that the optimal formula of No.1 buckwheat tea was Zi juan tea,llex kudigcha and Angelica keiskei extract ratio 4∶1∶2,the concentration of the mixture was 1%,spray volume and material ratio 0.5∶1.The optimal formula of No.2 buckwheat tea was Zi juan tea and llex kudigcha extract mixing ratio 3∶2,the concentration of the mixture was 0.5%,spray volume and material ratio 2∶1.The optimal formula of No.3 buckwheat tea was llex kudigcha and Angelica keiskei extract ratio 2∶1,the concentration of the mixture was 0.5%,spray volume and material ratio1∶1.
Dual Mating Studies in Psychiatry—offspring of inpatients with examples from reactive (psychogenic) psychoses

Field: Medicine (Health Sciences)

AbstractStudies on the offspring of dual mating psychiatric inpatients present a special high-risk strategy, analogous to the diallele cross methods of plant and animal genetics for Mendelian traits, except that the parents in dual matings have complex phenotypes, and all combinations of disorders may be observed. Previous studies have mainly been on the effects of homotypic parent combinations of schizophrenia or manic-depressive disorders, showing a 2–5-fold increase in the risk for similar disorders in the offspring compared to the risk for offspring of one affected parent. A study on heterotypic parent combinations allowing an exploration of genetic relationships among various disorders has been made possible through the use of the nation-wide Danish Psychiatric Register. All psychiatric inpatients who had offspring with other psychiatric inpatients were identified, yielding a total of 139 couples with non-organic mental disorders. Their 378 offspring were followed well into the risk periods for the major mental disorders. As an example to illustrate the complexities involved in analysis of data from a dual mating study, results for parent combinations involving reactive psychoses are presented.
Integrative chemo-immune-radiological treatment of HER2 positive breast cancer combined with a review of potential microRNAs involved and analysis of experimental results from sub-THz vibrational spectroscopy

Field: Medicine (Health Sciences)

In this paper we present the results of a Breast Cancer study by integrative analysis of a NIH approved treatment for HER2 positive breast cancer. This study is combined with analysis of Micro-RNA involvement from application of sub-THz spectroscopy for visualization of molecules circulating in blood by measuring saliva. The combination of Taxol-Generic Name-Paclitaxel (PT-J9267) and Trastuzumab-ANNS 0/0 and KadcylaTM (Genetic Name Ado-Trastuzumab Emtansine) were used in 3-stages of combined chemotherapeutic and immune-treatments followed by Radiation treatment. The goal of using PT was to stop spread of the disease to other organs outside of the breast and under arm lymph nodes, as well as to shrink the size of the tumor to facilitate surgery and radiology in continuation of the treatment. Trastuzumab (TZ) was added to PT in the 2nd step to prevent the development of chemoresistance. Intravenous infusion of Kadcyla was used mainly to prevent metastasis. Integrative analysis of microRNA participation was conducted based on literature review and sub-Terahertz vibrational spectroscopy measurements of absorption spectra from samples taken weekly before and after each treatment, using Vibratess’ spectrometer. The results from sub-THz spectroscopy in this work demonstrate dramatical modification of spectroscopic signatures from patient samples following disease development and the initial steps in the course of treatment. These changes reflect the deep global regulation (reduction) of the initially participating microRNAs amounts and changes in the microRNAs contributing to the spectra.
Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin

Field: Medicine (Health Sciences)

Background: Cardiac-specific myosin light chain kinase (cMLCK), encoded by MYLK3 , regulates cardiac contractility through phosphorylation of ventricular myosin regulatory light chain. However, the pathophysiological and therapeutic implications of cMLCK in human heart failure remain unclear. We aimed to investigate whether cMLCK dysregulation causes cardiac dysfunction and whether the restoration of cMLCK could be a novel myotropic therapy for systolic heart failure. Methods: We generated the knock-in mice ( Mylk3 +/fs and Mylk 3 fs/fs ) with a familial dilated cardiomyopathy–associated MYLK3 frameshift mutation ( MYLK3 +/fs ) that had been identified previously by us (c.1951-1G>T; p.P639Vfs*15) and the human induced pluripotent stem cell–derived cardiomyocytes from the carrier of the mutation. We also developed a new small-molecule activator of cMLCK (LEUO-1154). Results: Both mice ( Mylk3 +/fs and Mylk 3 fs/fs ) showed reduced cMLCK expression due to nonsense-mediated messenger RNA decay, reduced MLC2v (ventricular myosin regulatory light chain) phosphorylation in the myocardium, and systolic dysfunction in a cMLCK dose–dependent manner. Consistent with this result, myocardium from the mutant mice showed an increased ratio of cardiac superrelaxation/disordered relaxation states that may contribute to impaired cardiac contractility. The phenotypes observed in the knock-in mice were rescued by cMLCK replenishment through the AAV9_ MYLK3 vector. Human induced pluripotent stem cell–derived cardiomyocytes with MYLK3 +/fs mutation reduced cMLCK expression by 50% and contractile dysfunction, accompanied by an increased superrelaxation/disordered relaxation ratio. CRISPR-mediated gene correction, or cMLCK replenishment by AAV9_ MYLK3 vector, successfully recovered cMLCK expression, the superrelaxation/disordered relaxation ratio, and contractile dysfunction. LEUO-1154 increased human cMLCK activity ≈2-fold in the V max for ventricular myosin regulatory light chain phosphorylation without affecting the K m . LEUO-1154 treatment of human induced pluripotent stem cell–derived cardiomyocytes with MYLK3 +/fs mutation restored the ventricular myosin regulatory light chain phosphorylation level and superrelaxation/disordered relaxation ratio and improved cardiac contractility without affecting calcium transients, indicating that the cMLCK activator acts as a myotrope. Finally, human myocardium from advanced heart failure with a wide variety of causes had a significantly lower MYLK3 / PPP1R12B messenger RNA expression ratio than control hearts, suggesting an altered balance between myosin regulatory light chain kinase and phosphatase in the failing myocardium, irrespective of the causes. Conclusions: cMLCK dysregulation contributes to the development of cardiac systolic dysfunction in humans. Our strategy to restore cMLCK activity could form the basis of a novel myotropic therapy for advanced systolic heart failure.
A review of oral cancer screening and detection in the metropolitan Detroit cancer control program.

Field: Health Professions (Health Sciences)

In summarizing the experience of the twenty-seven months of the oral cancer screening and detection program the data indicate: 1.) Cancers were detected at earlier stages than is reported nationally. Further investigation is needed to determine whether there is a correlation between early detection and increased survival. (Kaufman 1980). 2.) The detection of fifteen precancerous lesions is significant in that intervention may have precluded malignant transformation. 3.) Of those found with oral cancers, eight were symptomatic and two were asymptomatic, while in the premalignant group five were symptomatic and seven were asymptomatic. On the basis of these data, it appears that the symptomatic group chose the screening program as a pathway of entry into the medical system. The motivation for this choice requires investigation. Possible hypotheses are: screening by a registered dental hygienist and in a familiar setting was less threatening than by a physician or dentist in a formal medical setting. The reputation of the MCF, as a center of excellence in cancer control, may have contributed to the willingness to be screened. 4.) The incidental detection of five skin and three laryngeal cancers was an aid to cancer control. 5.) The program successfully trained and utilized registered dental hygienists in oral cancer screening thereby demonstrating an economical use of professional health resources. Follow-up is needed to ascertain whether their training is successfully applied in private practice. 6.) Efforts to reach the high risk population were less productive than expected because, while target screening sites serviced heavy drinkers and smokers, their populations were sometimes less than 40 years-of-age. This finding suggests a need for more refined strategies for accessing high risk populations.
Empirical investigation of success factors for offshore software development outsourcing vendors

Field: Business, Management and Accounting (Social Sciences)

Offshore software development outsourcing is a contractual business of high-quality software production at offshore destinations with significant cost-saving. The objective of this research paper is to identify and analyse factors that are important to be addressed by vendor organisations in order to be competitive in outsourcing business. We have performed questionnaire surveys with 53 experts from a total of 20 different countries. We asked the participants to rank each success factor on a fivepoint scale to determine the perceived importance of each success factor. Our survey included success factors identified in the previous findings of our systematic literature review study. We have identified factors such as cost-saving and appropriate infrastructure, which are considered critical by the outsourcing clients. Our results indicate that appropriate infrastructure, cost-saving and efficient project management are common in three types of experts (i.e. junior, intermediate and senior). We identified cost-saving as being common in four groups of experts (i.e. developers, managers, senior managers and others). We have also identified cost-saving as being common in three types of organisations (i.e. small, medium and large). Cost-saving and appropriate infrastructure should be addressed by vendor organisations in order to compete in the offshore outsourcing business.