jimnoneill/paper-to-field-training huggingface dataset:
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Field: Health Professions (Health Sciences)

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Recent Advances in a Novel Anti-apoptosis Factor: Survivin

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Survivin is a recently identified member of the inhibitor of apoptosis protein (IAP)family, which inhibits processing of downstream effector caspase 3 and caspase 7 in cell receiving apoptotic stimulus. Unlike other IAP protein, found during embryonic and fetal development, survivin was completely down regulated and undetectable in normal adult tissues, and became prominently reexpressed in all of the most common cancers. Survivin plays important pole in regulation of cell cycle. Its expression in tumors has been associated with increased aggressiveness, recurrence and decreased patient survival. Survivin may be a new target for cancer therapy.
“We All Came Together on the Football Field” But …

Field: Social Sciences (Social Sciences)

This chapter assesses the role of sports in the transition to desegregated schools. It shows the many ways in which sports helped ease a transition to desegregated schools by uniting black and white fans around the common goal of beating their opponents on the field. Indeed, it is no surprise that many of those involved in the early years of school desegregation laud the role sports played in this historical social transition and locate the football field or the basketball court as the place blacks and whites, sitting by each other and cheering together for a common cause, worked through the initial tensions of school desegregation. However, the chapter also reveals how sports was not the panacea many had hoped, and discrimination of black players and coaches persisted both on and off the field long after the initial desegregation dust settled.
Physical Activity Category Classification Using The Actigraph Gt9x In Youth

Field: Health Professions (Health Sciences)

The ActiGraph GT9X includes an inertial measurement unit (IMU) equipped with a triaxial gyroscope which has been shown to be a perfect classifier of sedentary behavior (SB) in adults. To date, there has been no research to explore the application of the gyroscope in youth. PURPOSE: The purpose of this study was to compare the use of the accelerometer and gyroscope for classifying SB and continuous walking and running (CWR) in youth. METHODS: Participants (N=52, mean±SD; age, 13.3±3.1 years; BMI, 20.5±5.0 kg/m2) completed sixteen activities ranging from SB to vigorous intensity. Activities were grouped as SB (lying, computer gaming, internet, reclining, and book reading), CWR (fast over-ground walking, slow over-ground walking, and over-ground running), and intermittent activities (e.g. stair walking, sweeping, stationary cycling, basketball). A GT9X was worn on the right hip, both wrists, and both ankles. Primary accelerometer data were sampled at 90 Hz and converted to the Euclidean norm minus one (ENMO) in milli-G’s per second. Gyroscope data were sampled at 100 Hz and converted to vector magnitude (GVM) and reported in mean degrees per second. ENMO and GVM were assessed for classifying the following: 1). SB from all other activities and 2). SB first, then CWR from the remaining 11 activities using the mean coefficient of variation (CV) per 10-s. Thresholds were developed using receiver operating characteristics (ROC) Performance was assessed using area under the curve (AUC), sensitivity, and specificity. Performance RESULTS: ENMO and GVM classify SB well across all attachment sites (AUC ≥ 95.7%). When classifying CWR after removing SB, ENMO CV had AUC between 85.0%-87.9%, while GVM was lower and more variable with AUC between 53.3%-74.7%. CONCLUSION: Overall, ENMO and GVM are excellent classifiers of SB in youth across all attachment sites. GVM is less effective than ENMO for classifying CWR, but has potential for future use and should continue to be explored.Table: No title available.
Tumour Necrosis Factor-alpha Expression Is Associated with Increased Severity of Periprosthetic Breast Capsular Contracture

Field: Medicine (Health Sciences)

Background: The pathogenesis of periprosthetic capsular contracture following breast implant surgery is unclear. The aim of this study was to identify the expression of tumour necrosis factor-alpha (TNF-alpha), collagen type III alpha(1) (COL3A1), transforming growth factor-beta(1) (TGF-beta(1)) and connective tissue growth factor (CTGF) in different Baker grades of breast capsular contracture. Methods: Seven periprosthetic breast capsule specimens were collected from 6 patients. TNF-alpha, COL3A1, TGF-beta(1) and CTGF gene expression were analysed using real-time quantitative polymerase chain reaction. Immunohistolocalisation of TNF-alpha was performed on paraffin-embedded sections. Significant correlations were analysed using the Pearson correlation coefficient. Results: TNF-alpha expression was associated with increased Baker grade of capsular contracture (Pearson correlation, r = 0.558; p = 0.02). COL3A1 gene expression was reduced with increasing severity of contracture (r = -0.490; p = 0.05). There were no significant correlations between TGF-beta(1) and CTGF expression with Baker grade. Positive TNF-alpha staining in breast capsules was localised to fibroblasts, macrophages, and extracellularly close to the prosthesis. Conclusion: The increased expression of TNF-alpha may play a key role in the inflammatory response associated with capsular contracture. The corresponding decrease in COL3A1 may contribute to the change in capsular physical properties seen in capsular contracture. Copyright (C) 2010 S. Karger AG, Basel
Introduction

Field: Physics and Astronomy (Physical Sciences)

Decoherence and decay of quantum states in open systems is the main obstacle towards the realization of quantum computing and communications and a major impediment for coherent control (of atomic, molecular and condensed-phase processes) and quantum state engineering (of fields and atoms in cavities and trapped ions). This Focus Issue is an attempt to highlight the development of schemes for the control of quantum decay and decoherence, by presenting the major trends in this area. To this end, I have solicited a number of articles from groups that have been particularly active in the pursuit of these trends.
Turkish Nationalism and Turkish Union Project

Field: Social Sciences (Social Sciences)

In this study, the concept of Nationalism, which is of great importance for the present day, but the subject of little research in the academic field until the beginning of the 20th century, has been researched as the emergence of nationalism movement and the ethnic basis of the nations. There is both a danger and hope in the division of people into nations, persevering the power of national identity in every corner of the world. The study is based on a project for the Turkish world. The coverage area of the project is the Turkish states; Republic of Turkey being in the first place and including Azerbaijan, Uzbekistan, Turkmenistan, Kyrgyzstan, Kazakhstan. These states with a total population of over 300 million can come together like the European Union. We can call this union the Turkish Union.
A Taste for Soap Opera: Food, Television and the Transmedia Cookbooks of 7de Laan and Coronation Street, a Webinar with Sarah Gibson

Field: Arts and Humanities (Social Sciences)

This talk explores the articulation of food and television through an analysis of the soap opera genre and their transmedia cookbooks. Whilst debates on food &amp; literature and food &amp; film have been researched extensively, the relationship of food &amp; television remains relatively underexplored (Murray, 2012; Oren, 2003). This limited work has tended to focus on the cookery programme genre (Strange, 1998;
Effect of expression of intermediate-conductance Ca2+-activated K+ channels on proliferation, cell cycle, and apoptosis of human endometrial carcinoma.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Objective:To study the effects of expression level and activity alteration of intermediate-conductance Ca2+-activated K+(KCa3.1) channels on the cell proliferation,cell cycle,and apoptosis of endometrial carcinoma cells.Methods:The recombinant plasmid containing small interference RNA of KCa3.1 gene was transfected into endometrial cancer cell lines,HEC-1-A cell line and Ishikawa cell line.Real-time fluorogentic quantitative RT-PCR and Western blotting were used to examine the gene and protein expressions of KCa3.1 channels.Un-transfected cells and the cells transfected with negative plasmids served as control groups.The proliferation,cell cycle,apoptosis,and expressions of cyclin D1,cyclin E,survivin proteins of endometrial cancer cells were determined by MTT assay,BrdU incoporation test,flow cytometry,and Western blotting,respectively,after interference by KCa31 sepcific antagonist TRAM-34 or KCa3.1 RNAi plasmid.Results:KCa3.1 RNAi interference significantly inhibited the mRNA and protein expressions of KCa3.1 channels compared with control groups(P0.01).TRAM-34 and KCa3.1 RNAi interference markedly suppressed the cell proliferation of HEC-1-A and Ishikawa cells.Compared with control groups,the proportion of cells in G0/G1 phase of the two experiment cell lines was increased,while the proportion of cells in S phase was decreased.The difference was significant(P0.05).The apoptotic rataio had no significant changes in the two cell lines after treatment compared with control group(P0.05).The expression levels of cyclin D1,cyclin E,and survivin protein were significantly decreased in the experiment groups.The difference was significant compared with control group(P0.05).Conclusion:Inhibition of the expression and activity of KCa3.1 channels suppress cell proliferation,blocked cell cycle progression,but have no effect on apoptosis of endometrial cancer cells.
Neuroprotective effects of probiotics bacteria on animal model of Parkinson’s disease induced by 6-hydroxydopamine: A behavioral, biochemical, and histological study

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Parkinson's disease (PD) is an age-associated, progressive, and common neurodegenerative disorder. It is characterized by dopaminergic neuron degeneration in the substantia nigra pars compacta. The involvement of oxidative stress, inflammation, and dysbiosis in PD has been confirmed and probiotics also have the ability to regulate the mentioned mechanisms. Here, we assessed probiotics supplementation effects on experimental model of PD. Thirty Male Wistar rats were divided into three groups for a 14-day treatment. It was shown that a mixture of probiotics containing Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus reuteri, and Lactobacillus fermentum could improve rotational behavior, cognitive function, lipid peroxidation, and neuronal damage in the group received probiotic supplementation compared to the other groups (P < 0001, P < .001, and P = .026, respectively). Taken together, these findings revealed that probiotics supplementation could be an appropriate complementary treatment for PD.
British policy in relation to Sierra Leone, 1808–1852

Field: Social Sciences (Social Sciences)

Journal Article British policy in relation to Sierra Leone, 1808–1852 Get access G. R. Mellor, M.A. G. R. Mellor, M.A. Search for other works by this author on: Oxford Academic Google Scholar Bulletin of the Institute of Historical Research, Volume 14, Issue 41, November 1936, Pages 122–124, https://doi.org/10.1111/j.1468-2281.1936.tb00111.x Published: 12 October 2007
Heterogeneous Damage in Li-Ion Batteries: Experimental Analysis and Theoretical Modeling

Field: Materials Science (Physical Sciences)

We assess the heterogeneous electrochemistry and mechanics in a composite electrode of commercial batteries using synchrotron X-ray tomography analysis and microstructure-resolved computational modeling. We visualize the morphological defects at multi-scales ranging from the macroscopic composite, particle ensembles, to individual single particles. Particle fracture and interfacial debonding are identified in a large set of tomographic data of active particles. Mechanical failure in the regime near the separator is more severe than toward the current collector. The active particles close to the separator experience deeper charge and discharge over cycles and thus are more mechanically loaded. The difference in the Li activity originates from the polarization of the electrolyte potential and the non-uniform distribution of the activation energy for the charge transfer reaction. We model the kinetics of intergranular fracture and interfacial degradation to confirm that the various Li activities are the major cause of the heterogeneous damage. The interfacial failure may reconstruct the conductive network and redistribute the electrochemical activities that render a dynamic nature of electrochemistry and mechanics evolving over time in the composite electrodes. We further quantify the influence of the mechanical damage on the metrics of battery performance. We simulate the electrochemical impedance profile to build a relationship between the interfacial debonding and the impedance of electron transport and surface charge transfer. The mechanical failure disrupts the conduction path of electrons and results in significant polarization and capacity loss in batteries.
Tree-structured prognostic classification for censored survival data: validation of computationally inexpensive model selection criteria

Field: Mathematics (Physical Sciences)

The performance of computationally inexpensive model selection criteria in the context of tree structured prediction is discussed. It is shown through a simulation study that no one model selection criterion exhibits a uniformly superior performance over a wide range of scenarios. Therefore, a two-stage approach for model selection is suggested and shown to perform satisfactorily. A computationally efficient method of tree-growing within the RECursive Partition and AMalgamation (RECPAM) framework is suggested. The computationally efficient algorithm gives identical results as the original RECPAM tree-growing algorithm. An example of medical data analysis for developing prognostic classification is presented.
High Performance Implementation of Support Vector Machines Using OpenCL

Field: Computer Science (Physical Sciences)

Support Vector Machines are a machine learning approach that is well studied, thoroughly vetted and effective in a large number of applications. The objective of this thesis is to accelerate an implementation of Support Vector Machines (SVM) using a heterogeneous computing system programmed using OpenCL in C/C++. LIBSVM, a widely-available, popular and open source implementation of SVM is chosen, allowing the presented work to be integrated seamlessly into existing systems. The proposed framework is evaluated in terms of speed and accuracy when performing training and classification on a number of standard data sets. Testing was based on two work station GPUs, the NVIDIA GTX 480 and Tesla K20, and a modern, work station CPU (Intel i5 Quad Core, 3 GHz).\nWe find that, for large data sets, training is accelerated by a factor ranging from 9 to 22. In general, speedup increases with the total number of training samples in the data set until the GPU device is fully utilized. While these gains in speedup are significant, they do not match the ideal parallel speedup, that is the total number of cores in the parallel system. Our findings indicate that performance is hampered by the portions of the SVM training algorithm that are sequential. In addition, we find that the classification phase of the SVM system is accelerated by a factor of up to 12. During classification only a relatively small number of samples are classified compared to the typical number of training samples, and the computational complexity of classification grows only linearly with the number of samples processed, as opposed to the training phase where it grows quadratically. The contri- butions of this thesis include the use of OpenCL for accelerating SVM training and testing on heterogeneous systems, and the performance analysis of the acceleration of SVM.
Investigation of Structural Capacity of Geogrid-Reinforced Aggregate Base Materials in Flexible Pavements

Field: Engineering (Physical Sciences)

The installation of geogrid as a means of extending the service life of a roadway or reducing the required base course thickness of a pavement structure has become increasingly popular. The realization of these benefits depends largely on the degree to which the geogrid reinforcement leads to an increase in the stiffness of the aggregate base course layer. The objective of this research was to investigate the structural capacity of geogrid-reinforced aggregate base materials in flexible pavements through full-scale testing. The scope involved field testing at two sites in northern Utah that each included five different geogrid-reinforced sections and five accompanying unreinforced control sections. Five different geogrid types were utilized to ensure that the experimentation was representative of the geogrid products available in the industry at the time of the study. At each of the two field sites, 10 test sections were established, and several field tests were conducted during and following construction of the two pavements to characterize the in-situ structural properties of the subgrade, base, and hot mix asphalt layers of each geogrid-reinforced and unreinforced test section. The procedures involved nuclear density gauge, soil stiffness gauge, Clegg impact soil tester, dynamic cone penetrometer (DCP), portable falling-weight deflectometer, and falling-weight deflectometer testing of each test section. Samples of the subgrade and base materials were also obtained from both field sites for laboratory testing, which included dry and washed sieve analyses, Atterberg limits testing, and material classification. An analysis of covariance (ANOCOVA) was conducted on the results of each field test to determine if the structural capacity of the geogrid-reinforced sections was different than that of the accompanying unreinforced control sections.Among the 24 ANOCOVA models developed for the two field sites, only four indicated that geogrid presence was statistically significant. Of these four models, three indicated that the presence of geogrid reinforcement led to higher values of the given measurement of structural capacity compared to the unreinforced condition; however, in none of the cases was the difference practically important as defined in this research and would therefore not result in a different input in the pavement design process. Notably, in all three of these models, the same testing procedure, namely the DCP, was used for the testing. A measurable increase in the structural capacity of the reinforced layer may not be immediately observable using standard pavement testing procedures. Further field research is recommended to investigate the duration of the required conditioning period and also the extent of the zone of influence of geogrid reinforcement in aggregate base courses.
Plant Volatiles Mediate Host Selection of Sitodiplosis mosellana (Diptera: Cecidomyiidae) among Wheat Varieties

Field: Agricultural and Biological Sciences (Life Sciences)

Sitodiplosis mosellana is a major wheat pest that oviposits on spikes, and resistant wheat varieties have been released. However, wheat spike volatiles mediating S. mosellana host selection or resistance are largely unknown. In this study, we found that the highly susceptible wheat varieties Xinong 822, Xinong 88, and Xiaoyan 22 were preferred for S. mosellana oviposition, and their spike volatiles were more attractive to females compared to the resistant varieties Kenong 1006, Shanmai 139, and Jinmai 47. Importantly, we found five odor components evoking obvious concentration-dependent electroantennogram (EAG) and behavioral response. Notably, 3-hexanol, cis-3-hexenylacetate, and hexyl acetate strongly attracted females, whereas ocimene, a dominant component of three resistant varieties, and α-farnesene, absent in Xinong 88, repelled females. Significant attraction was also observed in a synthetic blend mimicking Xinong 822 volatiles. These results suggest that these wheat volatiles are involved in host selection of S. mosellana and provide a basis for development of semichemical-based pest management.