jimnoneill/paper-to-field-training huggingface dataset:
Designing Game Feel: A Survey

Field: Computer Science (Physical Sciences)

Game feel design is the intentional design of the affective impact of\nmoment-to-moment interaction with games. In this paper we survey academic\nresearch and publications by practitioners to give a complete overview of the\nstate of research concerning this aspect of game design, including context from\nrelated areas. We analysed over 200 sources and categorised their content\naccording to the design purpose presented. This resulted in three different\ndomains of intended player experiences: physicality, amplification, and\nsupport. In these domains, the act of polishing that determines game feel,\ntakes the shape of tuning, juicing, and streamlining respectively. Tuning the\nphysicality of game objects creates cohesion, predictability, and the resulting\nmovement informs many other design aspects. Juicing is the act of polishing\namplification and it results in empowerment and provides clarity of feedback by\ncommunicating the importance of game events. Streamlining allows a game to act\non the intention of the player, supporting the execution of actions in the\ngame. These three design intents are the main means through which designers\ncontrol minute details of interactivity and inform the player's reaction. This\nframework and its nuanced vocabulary can lead to an understanding of game feel\nthat is shared between practitioners and researchers as highlighted in the\nconcluding future research section.\n
Magnetic resonance imaging of intracranial aneurysms.

Field: Medicine (Health Sciences)

Intracranial aneurysms are lesions with high morbidity and mortality, but in most cases represent treatable disease. Magnetic resonance (MR) imaging and in some cases MR angiography can make valuable contributions to their diagnosis and characterization. The ultimate tool for imaging these lesions, however, remains catheter angiography. This article focuses on saccular aneurysms, with a brief discussion on atherosclerotic fusiform aneurysms and mycotic aneurysms.
Is it gambling or a game? Simulated gambling games: their use and regulation

Field: Social Sciences (Social Sciences)

Simulated gambling games mimic the characteristics of gambling games but do not provide an opportunity to stake, win or lose real-world money. People who play simulated gambling games are more likely to gamble commercially and report gambling problems. The convergence of gambling and gaming alongside an increase in advertising has led to increased exposure to, and possible normalisation of, gambling. It is the conclusion of this paper that strengthening and standardising classification of games, and adding advisory warnings, would provide more protections to users.
Role of Nuclearity-Dependent Properties of Small Clusters in the Nucleation Process and Thermal Hysteresis at the Phase Transition

Field: Chemistry (Physical Sciences)

A phenomenological approach is proposed that takes into account the nuclearity-dependent binding energy in a cluster to determine its influence on the earliest steps of the homogeneous nucleation process and to determine the limits of the metastability/supersaturation domain for the monomer-condensed phase transition. It appears that the temperature at which monomers and clusters Mn have equal Gibbs potentials increases with nuclearity n and that the transition temperatures from the monomer to the dimer and to the bulk, respectively, bracket this metastability domain.
Exosomes from mesenchymal stem cells overexpressing MIF enhance myocardial repair

Field: Medicine (Health Sciences)

Abstract Accumulating evidence has shown that mesenchymal stem cell (MSC)‐derived exosomes (exo) mediate cardiac repair following myocardial infarction (MI). Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, plays a critical role in regulating cell homeostasis. This study aimed to investigate the cardioprotective effects of exo secreted from bone marrow‐MSCs (BM‐MSCs) overexpressing MIF in a rat model of MI. MIF plasmid was transducted in BM‐MSCs. Exo were isolated from the supernatants of BM‐MSCs and MIF‐BM‐MSCs, respectively. The morphology of mitochondria in neonatal mice cardiomyocytes (NRCMs) was determined by MitoTracker staining. The apoptosis of NRCMs was examined by deoxynucleotidyl transferase‐mediated dUTP nick end‐labeling. BM‐MSC‐exo and MIF‐BM‐MSC‐exo were intramuscularly injected into the peri‐infarct region in a rat model of MI. The heart function of rats was assessed by echocardiography. The expression of MIF was greatly enhanced in MIF‐BM‐MSCs compared with BM‐MSCs. Both BM‐MSC‐exo and MIF‐BM‐MSC‐exo expressed CD63 and CD81. NRCMs treated with MIF‐BM‐MSC‐exo exhibited less mitochondrial fragmentation and cell apoptosis under hypoxia/serum deprivation (H/SD) challenge than those treated with BM‐MSC‐exo via activating adenosine 5′‐monophosphate‐activated protein kinase signaling. Moreover, these effects were partially abrogated by Compound C. Injection of BM‐MSC‐exo or MIF‐BM‐MSC‐exo greatly restored heart function in a rat model of MI. Compared with BM‐MSC‐exo, injection of MIF‐BM‐MSC‐exo was associated with enhanced heart function, reduced heart remodeling, less cardiomyocyte mitochondrial fragmentation, reactive oxygen species generation, and apoptosis. Our study reveals a new mechanism of MIF‐BM‐MSC‐exo‐based therapy for MI and provides a novel strategy for cardiovascular disease treatment.
Vodní měkkýši přírodních rezervací Žabakor, Podtrosecká údolí a Údolí Plakánek v CHKO Český ráj [Aquatic molluscs of nature reserves Žabakor, Podtrosecká údolí and Údolí Plakánek in the Český ráj PLA]

Field: Agricultural and Biological Sciences (Life Sciences)

Aquatic molluscs of three extensive nature reserves (Žabakor, Podtrosecká údolí, Údolí Plakánek) in the Český ráj Protected Landscape Area (northern Bohemia) were studied in 2019. Altogether 33 mollusc species were found at 40 studied sites including streams, fishponds, pools, and wetlands. Results were compared with previous research. The occurrence of endangered bivalves Sphaerium nucleus and Pisidium amnicum was confirmed. Two non-native species Physa acuta and Ferrissia californica were recorded.
Determinants of Intention to Purchase Photovoltaic Panel System: An Integration of Technology Acceptance Model and Theory of Planned Behaviour

Field: Economics, Econometrics and Finance (Social Sciences)

The emission of carbon dioxide and other greenhouse gases through electricity consumption by firms is one the significant drivers of climate change. Renewable energy can help to minimise the ecological footprint associated with the production and consumption of fossil fuels. Drawing on the Technology Acceptance model (TAM) and an extended Theory of Planned Behaviour (TPB), the study examined the determinants of intention to purchase rooftop photovoltaic (PV) panel system in residences in South Africa.. The quantitative research design was adopted for the study and the cross-sectional survey method was used for data collection. The hypotheses of the study were tested using the Partial Least Square Structural Equation modelling (PLS SEM). The results of the empirical study indicated that environmental concern, green perceived usefulness, perceive ease of use are associated with attitude and intention to purchase rooftop photovoltaic (PV) panel system. In addition, attitude, perceived behavioural control and awareness are positively related to intention to purchase rooftop photovoltaic (PV) panel system. Theoretically, the study confirms the applicability of an integrated model that consists of the TAM and TPB in explaining the intention to install rooftop photovoltaic (PV) panel system. Recommendations to improve the adoption of rooftop photovoltaic (PV) panel system in residences are suggested.
Considerations for the orthopedic nurse in diagnosis and treatment of adolescent sports injuries.

Field: Nursing (Health Sciences)

Injured adolescent athletes are challenging clients for the primary practitioner. Their unique physiological and psychological attributes dictate changes in traditional orthopedic practice and call for a holistic patient focus to address their varied needs. Understanding of common athletic injuries will effectively guide the practitioner's clinical evaluation and assist in recognizing those patients requiring more complex orthopedic diagnosis and care.
In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract under Fed and Fasted Conditions

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate the in vivo drug dissolution and systemic absorption of the BCS class IIa drug ibuprofen under fed and fasted conditions by direct sampling of stomach and small intestinal luminal content. Expanding current knowledge of drug dissolution in vivo will help to establish physiologically relevant in vitro models predictive of drug dissolution. A multilumen GI catheter was orally inserted into the GI tract of healthy human subjects. Subjects received a single oral dose of ibuprofen (800 mg tablet) with 250 mL of water under fasting and fed conditions. The GI catheter facilitated collection of GI fluid from the stomach, duodenum, and jejunum. Ibuprofen concentration in GI fluid supernatant and plasma was determined by LC-MS/MS. A total of 23 subjects completed the study, with 11 subjects returning for an additional study visit (a total of 34 completed study visits). The subjects were primarily white (61%) and male (65%) with an average age of 30 years. The subjects had a median [min, max] weight of 79 [52, 123] kg and body mass index of 25.7 [19.4, 37.7] kg/m2. Ibuprofen plasma levels were higher under fasted conditions and remained detectable for 28 h under both conditions. The AUC0-24 and Cmax were lower in fed subjects vs fasted subjects, and Tmax was delayed in fed subjects vs fasted subjects. Ibuprofen was detected immediately after ingestion in the stomach under fasting and fed conditions until 7 h after dosing. Higher levels of ibuprofen were detected in the small intestine soon after dosing in fasted subjects compared to fed. In contrast to plasma drug concentration, overall gastric concentrations remained higher under fed conditions due to increased gastric pH vs fasting condition. The gastric pH increased to near neutrality after feedingbefore decreasing to acidic levels after 7 h. Induction of the fed state reduced systemic levels but increased gastric levels of ibuprofen, which suggest that slow gastric emptying and transit dominate the effect for plasma drug concentration. The finding of high levels of ibuprofen in stomach and small intestine 7 h post dosing was unexpected. Future work is needed to better understand the role of various GI parameters, such as motility and gastric emptying, on systemic ibuprofen levels in order to improve in vitro predictive models.
A case of intense and multiple parasitic infestation in a wild pigeon (Columbia livia).

Field: Veterinary (Health Sciences)

Introduction The prevalence of parasitic diseases in poultry seems to have significantly reduced due not only to the intensive production system but also to the improving conditions of hygiene and management practiced. However, parasitic diseases continue to have great importance in traditional production systems and production systems in the outdoors, contributing significantly to productivity decline of these farms. The pigeon (Columbia livia), a specie produced with outdoors access is more susceptible to infestations. The growing population of wild pigeons in urban areas can be decisive in the infestation of domestic pigeons, since they share the same places and their sanitary control is more difficult. Objectives The aim of this work is to describe a case of a pigeon (Columbia livia) with an intense parasitic infestation, this being the cause of death, with common parasitic species and other less frequent. Material and Methods A cadaver of a pigeon was submitted to the necropsy of Anatomic Pathology Laboratory of the Agrarian Superior School of Viseu, a detailed post mortem examination was carried out and samples were taken. All samples were fixed in 10% neutral-buffered formalin, for a maximum of 48 hours and processed following the routine histopathological technique. Results Gross examination lesions revealed rounded red lesions in the proventriculus serosa and lung congestion. Microscopic examination confirmed severe lung congestion, with hemosiderosis and the presence of numerous nematodes in cross section, discussing the hypothesis that it might be a case of Cyathostoma bronchialis (Muehlig 1884), taking into account the location or, less likely, an erratic parasite in histotropic migration phase. Eggs observed at this location had thick shell, oval shape, some were embryonated and 35-40 μm in length by 20-25 μm in width. In the lumen of the proventriculus glands, nematodes in cross section were also observed, noting numerous barrel-shaped eggs, embryonated larvae, oval poles and 55 mm in length by 25 mm in width, apparently compatible with parasites of the genus Tetrameres. Conclusion The high parasitic infestation of the wild pigeon specimen subjected to necropsy, with several, common and uncommon, species of parasites, the severity of lesions, leading to death of the animal, as well as the fact that infected wild birds favoring the spread of the parasite to the domestic pigeons and other poultry production, consisting of a major concern for producers, justifies the study of isolated cases, even constituting an epidemiological alert for the regions where they appear.
The current status of gene therapy in bladder cancer

Field: Medicine (Health Sciences)

Recent transformative breakthroughs in bladder cancer research have deeply characterized the major epigenetic and genetic alterations of bladder cancer and have radically transformed our view of tumor biology and generated new hypotheses for therapy. These advances provided the opportunity to begin to optimize strategies for effective gene therapy for bladder cancer. Clinical trials have shown promising results, especially in BCG-unresponsive non-muscle-invasive bladder cancer (NMIBC), where effective second-line therapy remains an unmet need for patients facing cystectomy. Efforts are underway to develop effective combination strategies targeting resistance mechanisms to gene therapy for NMIBC.
Qubit-induced high-order nonlinear interaction of the polar molecules in a stripline cavity

Field: Physics and Astronomy (Physical Sciences)

By the exchange of virtual microwave photon induced by a stripline cavity, we present a collective spin-qubit model for the indirect interaction between a superconducting charge-phase qubit and an ensemble of the polar molecules. More importantly, the high-order nonlinear interaction among the polar molecules is generated successfully by using the SU(2) commutation relations of the qubit. Numerical simulation shows that this high-order nonlinear interaction can lead to a strong macroscopic quantum coherent effect, even if the parameters including the molecular number are small. For a large molecular number, the Kerr nonlinear interaction is also obtained. Moreover, it is found that this Kerr nonlinear parameter depends linearly on the molecular number, and as a result, has a giant value, which is 2 to 3 orders of magnitude larger than that in the other proposal schemes of the solid-state systems. Our results present a way to investigate the quantum nonlinear dynamics of the polar molecules.
Surgical complications of the Breast reconstruction with implants(BRI)

Field: Medicine (Health Sciences)

Surgical complications of the Breast reconstruction with implants(BRI)Co-authorstG. Horton1, C. gon2, V. sanchotena2, E. bonavia1, R. garrido1, D. Martinez1, S. milone1, A. aragona1, A. soderini1.1hospital de oncologia maria curie, oncologia ginecologica, buenos aires, Argentina.2hospital de oncologia maria curie, mastologia, buenos aires, Argentina.Abstract texttObjectives:: To evaluate the complications & solutions of the BRI.Methods:Retrospective study that included 70 cases of BRI between 1/2009 - 1/2019 at the Oncology Hospital Marie Curie and private centersDelayed breast reconstruction after mastectomy (DBR) ,and Inmediate breast recostruction(IBR): nipple sparing mastectomy (NSM) and skin sparing mastectomy (SSM)Complications, solutions, stage of disease and follow up were anlyzed. ResultsThe 70 patiens were 59 cases of breast cancer and 11 cases Phillodes.The DBR were 19 cases In the 51 IBR: 29 NSM and 22 SSM cases,the complications were:NSM with one step implants scar dehiscence occurred in 7 patients (10%), it was resolved by drying necrotic tissue and restoring muscle and skinThe spontaneous deflation expander occurred in 4 patients (5.71%), it was saved with the re-insufflation of the expander in 3 of them (75%) and it was replaced with implants. 2 expanders(2.8%) were punctured at the time of insufflation and were removed (2.8%) Infections occurred in 4 patients( 5.71 %) In 3 cases, the implant could be washed and reinserted.Flap necrosis in 2 patients (2.8%) of SSM. It was solved deflating and resected the necrosis areaThe rotation of the valve was in 2 definitive expanders,a second intervention was carried out to rearrange itConclusions:: this study showed, in our sample of patients, that, the complications DBR and IBR procedures could be managed in a conservative manner.
Drought stress and its characteristics in China from 2001 to 2020 considering vegetation response and drought creep effect

Field: Environmental Science (Physical Sciences)

Study area: China Study focus: Drought is an extremely serious disaster, typically characterized by slow onset, long duration, and cumulative impacts on multifaceted aspects. Developing a combined index that integrates its various characteristics can help deepen our understanding of drought evolution and provide accurate references for farmers to take drought mitigation measures. In this study, we proposed a Modified version of the Type Response-Aided Drought Index (MTRADI), simultaneously considering the various responses of different vegetation and the slow-varying properties of drought development. New hydrological insights for the regions: The suitability of MTRADI was evaluated through correlation analysis with Palmer Drought Severity Index (PDSI) and qualitative comparison with Meteorological Drought Composite Index (MCI) maps. The MTRADI achieved significantly higher correlation coefficients with the PDSI, outperforming other combined drought indices. Based on the run theory, Mann-Kendall (MK) test, and Sen’s slope, drought characteristics and trends in mainland China during 2001–2020 were analyzed and the results show that drought frequency and severity are relatively higher in eastern Inner Mongolia, North China Plain, and Northeast of China. Furthermore, areas with significant wetting trends are observed to be mainly distributed near the Hu line, indicating that the water conditions in China are gradually improving at the transition zone of arid and humid climate regions.
Technical Evolution of Advanced Flywheel Energy Storage System

Field: Energy (Physical Sciences)

The flywheel energy storage system (FESS) is a new type of technology of energy storage, which has high value of the research and vast potential for future development. The FESS has distinct advantages such as high energy storage, high efficiency, pollution-free, wide in application, absence of noise, long lifetime, easy maintenance and continuous working and so on, which provides a new way to solve the terrible energy problem. Its operation principle, and five key technologies including the flywheel rotor, bearing system, energy conversion aspect, motor/generator and vacuum chamber are expounded. Then, the technical evolution of FESS at home and abroad is presented in detail, the application prospect of FESS is also given, and moreover, the research outlook of FESS is pointed out.
Reasons for consuming rasi as a staple food for the Cireundeu indigenous people: a qualitative study

Field: Social Sciences (Social Sciences)

Rasi (made from cassava) are used as staple food by the Cireundeu indigenous people. This food culture is considered different from the food culture of Indonesian people who generally make rice as their staple food. Therefore, this study aimed to show the reasons Cireundeu indigenous people consume rasi as their staple food. This qualitative research was conducted in Cireundeu Village, Cimahi City, West Java Province, Indonesia. Data was collected from the Cireundeu indigenous people through in-depth interviews and participant observation. Rasi are consumed by the Cireundeu indigenous people for six reasons: efforts to respect ancestral struggle, undergo ancestral revelation, independence in both physical and mental, obtain a source of strength/carbohydrate/energy, obtain a source of energy–saving and preserve tradition. All of that is supported by the existence of cassava production activities in the Cireundeu Village environment. The reason for consuming rasi as staple food comes from within themselves. This food culture can be used as a reference in development of sustainable and contextual national food security (based on local knowledge).
Grapevine downy mildew control in organic farming.

Field: Agricultural and Biological Sciences (Life Sciences)

Cupric products at low dose and alternative compounds have been tested to control the downy mildew in an organic vineyard. It has found that copper compounds control downy mildew in a satisfactory way, reducing, at the same time, the dose of copper metal. The alternative products were not satisfactory to control Plasmopara viticola.
Public Opinion and Public Support in Crisis Management

Field: Social Sciences (Social Sciences)

In times of crisis, citizens look to their leaders for aid and assistance. In the democratic context, the focal figure is likely the chief executive accountable to the whole of the nation. With a specific focus on the American president and the incidences of natural hazards, public opinion and governmental response to these crises are analyzed. While one may expect such a universal actor to aid each according to their need, new scholarship finds that voter behavior and electoral institutions incentivize the president to support only a small slice of the electorate. Empowered by federal disaster relief legislation in the 1950s, the president targets electorally valuable voters when disbursing aid or allocating resources in response to disaster damage. Voters in those areas respond myopically and tend to vote for the incumbent for reasons ranging from economic to emotional. Thus, elites anticipate voter reactions and strategically respond to disasters to mitigate blame or punishment for the event and capitalize on an opportunity for electoral gains.
Macromycetes of beech forests within the eastern part of the Fagus area in Europe

Field: Agricultural and Biological Sciences (Life Sciences)

This work presents the author's view on the habitat if individual forest communities based on the fungi she has collected and gives a comparison of the mycoflora of beech forest in Poland and in south and central Europe. The beech forest were studied by the phytosociological method. Fruit bodies occurring on the soil, in the litter and on rotten wood were studied.