jimnoneill/paper-to-field-training huggingface dataset:
Impairment of SHOX nuclear localization as a cause for Leri-Weill syndrome

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

We report the characterization of the nuclear localization signal (NLS) of the short stature homeobox gene SHOX. Mutations within the SHOX gene cause Léri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia (LD) as well as idiopathic short stature (ISS). Furthermore, haploinsufficiency of SHOX has also been implicated in Turner syndrome. SHOX has been shown to be a cell-type-specific transcriptional activator that localizes to the nucleus. The SHOX protein contains a central homeodomain that together with its transactivation domain regulates the transcription of its target sequences within the nucleus. The sequences for its nuclear localization have not been identified yet. Experimental characterization of SHOX-NLS by deletion mapping identified a non-classic type basic signal, AKCRK, in the recognition helix of the homeodomain. Fusion of this stretch of five amino acids to a cytoplasmic reporter protein resulted in its nuclear translocation. Functional analysis of a missense mutation R173C (C517T) affecting the identified SHOX-NLS in two families with LWS and LD showed that the mutated SHOX protein is unable to enter the nucleus. Conversely, we can demonstrate that insertion of the identified signal adjacent to the mutant site can restore its nuclear translocation. These results establish impairment of nuclear localization as a mechanistic basis for SHOX-related diseases.
NF&#954;B Pathway and microRNA-9 and -21 are Involved in Sensitivity to the Pterocarpanquinone LQB-118 in Different CML Cell Lines

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Chronic myeloid leukemia (CML), a myeloproliferative disorder characterized by the BCR-ABL oncoprotein, presents its treatment based on tyrosine kinase inhibitors (TKIs), mainly imatinib. However, despite its clinical success, almost 30% of all CML patients demand alternative therapy. In this context, the development of drugs capable of overcoming TKIs resistance is imperative. The pterocarpanquinone-LQB-118 is a novel compound with anti-tumor effect in CML cells whose mechanism of action is being elucidated. Here, we demonstrate that in two CML cell lines exhibiting different biological characteristics, LQB-118 modulates NFκB subcellular localization, apparently independently of the AKT and MAPK pathways, partially inhibits proteasome activity, and alters the expression of microRNAs -9 and -21.
The Effect of Role Ambiguity and Organizational Justice on Cyberloafing with Job Stress as a Mediation Variable

Field: Business, Management and Accounting (Social Sciences)

The development of technology, especially the internet, is beneficial in any case, including work. Despite the many benefits of the internet, its widespread use in the workplace has inadvertently formed a new pattern of deviant behavior called cyberloafing. This study aimed to analyze the effect of role ambiguity and organizational justice on job stress and cyberloafing. The research method used is quantitative by using a questionnaire for data collection. A sample of 104 respondents was taken by accidental sampling technique. The instrument used in this research is a questionnaire in the form of a google form distributed through social media, email, and others. The data analysis technique of this research uses Partial Least Square (PLS) with Smart-PLS software as an analytical tool. Based on the results of the study, it can be concluded that the variables of work ambiguity and organizational justice affect work stress. Role ambiguity and organizational justice were also found to influence cyberloafing behavior. However, this study did not support the research hypothesis about job stress mediating the effect of role ambiguity and organizational justice on cyberloafing.
No, there was no red

Field: Arts and Humanities (Social Sciences)

Hannah Rickards’s two-screen film is based on spoken accounts of a displaced image of a city seen over Lake Michigan as the result of rare temperature inversion mirages. The subjective divergences, consistencies, echoes and counterpoints of these accounts, form the core of the piece. \n \nNo, there was no red is a two-screen rear projection, centered on the framing of description in language, gesture and sound. It explores the relationship between atmospheric phenomena and experience of them. Beginning from research in to an optical atmospheric occurrence, a projected image caused by a temperature inversion and working with a group made up of its witnesses, Rickards recorded their descriptions. \n \nThe work is built gradually and is the result of a painstaking process of accumulation, transcription, organisation and re-working of material in order to compose a piece that can use that material musically, finding in it the rhythms and pauses, counterpoint of voice and gesture to sit within the diagrammatic structures of the piece. Those musical textures are not limited to sound or the voice of those filmed, but extend in to the geometries of the surroundings within the footage, the changing or passing light, as well as gestures or movements made by those figures. \n \nThe rear projection of the work reiterates the displacement of the image in a temperature inversion mirage, in which an image is displaced vertically and laterally from beyond the horizon. Thus the vantage point for the work being towards the source of the image: the projection mediated by the two screens, which themselves form a horizontal line. \n \nWhat is being described in the work is an image in relation to a horizontal line, and is described in terms of a long rectangle or a ‘really long, long photograph’ - the two screens therefore echo this long rectangle, with the angling of the screens (which are joined along the middle to produce one internal space on the screen) locating a viewer in relation to the three chairs in visible in the room. The room in which the work was filmed is a meeting room in a town community centre, and elements of the room (projection screens, windows and blinds, skirting boards, fire alarms) used or referred to by the participants in the piece.
Psychological Distress and Domestic Violence Under COVID-19 Lockdown in LGBT+ Persons in Belgium, Germany, and Portugal

Field: Psychology (Social Sciences)

Abstract: Background: During the COVID-19 pandemic, governments worldwide issued lockdown and social-distancing measures, which triggers psychological distress and may increase the occurrence of domestic violence (DV). We examined the role of the LGBT+ status in the relationship between risk factors of DV and its occurrence during the pandemic. Methods: In this cross-sectional study (n = 5,148), an online self-report questionnaire was administered to a non-probabilistic sample of participants living in Belgium, Germany, and Portugal between March and June 2020. Participants were sampled through national media, social media, and snowballing procedures. Results: LGBT+ persons reported significantly higher levels of perceived stress, more acute stress symptoms, and more illegal drug use during the first weeks of the lockdown compared to non-LGBT+ persons. DV in LGBT+ persons was not more prevalent than in the non-LGBT under COVID-19 lockdown measures. No significant evidence was found indicating that identifying as LGBT+ itself increases the risk of DV exposure. Conclusion: LGBT+ persons were more at risk of DV compared to non-LGBT+ persons prior to but not during COVID-19 lockdown measures. The increased risk for DV can be linked to socio-demographic characteristics, levels of stress, and illegal drug use which are more prevalent in LGBT+ persons than in non-LGBT+ persons.
#2366 Epigenetic and transcriptional landscape of the kidney in heart failure with preserved ejection fraction

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Background and Aims Heart failure with preserved ejection fraction (HFpEF) and chronic kidney disease (CKD) constitute a high-risk phenotype with significant morbidity and mortality and poor prognosis. Multiple proinflammatory comorbid conditions influence the pathogenesis of HFpEF and CKD. The understanding of the molecular mechanisms underpinning kidney damage cardio-renal interactions in HFpEF remains poorly understood. Unveiling new molecular targets could pave the way for new mechanism-based interventions to prevent HFpEF and CKD progression. Method A mouse model of HFpEF, characterized by the combination of high-fat diet (60 kcal% fat,) and L-NAME in the drinking water (0.5 g/L) for 15 weeks was employed. Control mice received a control diet (10 kcal% fat,) and vehicle in the drinking water (Fig. 1A). Deep renal phenotyping in control and HFpEF mice was performed by: i) renal biomarker profiling; ii) histological analysis; iii) RNA sequencing; iv) proteomics; v) CUT&RUN assay to investigate chromatin accessibility (Fig. 1B). Results HFpEF mice displayed renal dysfunction as assessed by increased creatinine, cystatin C and galectin-3 levels (Fig. 1C) as well as alterations of tissue architecture as shown by Collagen 1A1 and Periodic acid-Schiff (PAS) staining (Fig. 1D). Bulk RNA-seq and proteomic analyses unveiled three top-ranking signals in HFpEF vs control kidneys, namely Kynureninase (KYNU), Receptor Accessory Protein 6 (REEP6), and Retinol Dehydrogenase 16 family member 2 (RDH16F2) (Fig. 1E). Analysis of the chromatin landscape by CUT&RUN assays identified increased accessible loci in HFpEF vs control kidneys, with a prominent role of epigenetic readers (BET proteins) in regulating the transcription of target genes. Of interest, enhanced BET protein enrichment was associated with kidney inflammation and fibrosis in HFpEF mice. Conclusion HFpEF is associated with relevant epigenetic and transcriptional alterations in the kidney, eventually promoting organ dysfunction and structural remodeling. Our study sheds light on epigenome-environment interactions and new molecular targets potentially implicated in the progression of cardio-renal damage in HFpEF.
Parental Online Information Access and Childhood Vaccination Decisions in North America: Scoping Review

Field: Health Professions (Health Sciences)

BACKGROUND: Immunizing children throughout their early years prevents the spread of communicable disease and decreases the morbidity and mortality associated with many vaccine-preventable diseases. Searching online allows individuals rapid access to health information. OBJECTIVE: The purpose of this review was to develop an understanding of the existing literature of parents' online health information-seeking behaviors to inform their vaccination choices for their children and to identify gaps in the literature around parents' use of online health information and their vaccination choices. METHODS: A scoping review of peer-reviewed literature from Canada and the United States was performed. The following databases were utilized to perform the search: PubMed, CINAHL, Nursing & Allied Health Database, Scopus, and PsycINFO. The purpose of this review was to examine parents' use of online information seeking related to vaccine information and to understand how parents utilize this information to inform decisions about vaccinating their children. Of the 34 papers included in the review, 4 relevant themes and subthemes were identified: information seeking, online information resources, online vaccine content, and trust in health care providers. RESULTS: Examination of the literature revealed conflicting information regarding parents' use of social media and online resources to inform decisions around vaccinating their children. There is evidence of significant misinformation regarding vaccine risks online. Parents' digital health literacy levels are unknown and may affect their ability to appraise online vaccination information. CONCLUSIONS: Parents are seeking vaccine information from online sources. However, the influence of online vaccine information on parental vaccine practices remains uncertain.
Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections

Field: Immunology and Microbiology (Life Sciences)

Many Gram-positive bacteria covalently tether their surface adhesins to the cell wall peptidoglycan. We find that surface proteins of Staphylococcus aureus are linked to the cell wall by sortase, an enzyme that cleaves polypeptides at a conserved LPXTG motif. S. aureus mutants lacking sortase fail to process and display surface proteins and are defective in the establishment of infections. Thus, the cell wall envelope of Gram-positive bacteria represents a surface organelle responsible for interactions with the host environment during the pathogenesis of bacterial infections.
Bladder Cancer, Version 5.2017, NCCN Clinical Practice Guidelines in Oncology

Field: Medicine (Health Sciences)

This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Bladder Cancer focuses on systemic therapy for muscle-invasive urothelial bladder cancer, as substantial revisions were made in the 2017 updates, such as new recommendations for nivolumab, pembrolizumab, atezolizumab, durvalumab, and avelumab. The complete version of the NCCN Guidelines for Bladder Cancer addresses additional aspects of the management of bladder cancer, including non-muscle-invasive urothelial bladder cancer and nonurothelial histologies, as well as staging, evaluation, and follow-up.
A new species of the genus Scutiger (Anura: Megophryidae) from southeastern Tibet, China

Field: Agricultural and Biological Sciences (Life Sciences)

Jiang, Ke, Rao, Dingqi, Yuan, Siqi, Wang, Jishan, Li, Pipeng, Hou, Mian, Che, Maihe, Che, Jing (2012): A new species of the genus Scutiger (Anura: Megophryidae) from southeastern Tibet, China. Zootaxa 3388: 29-40, DOI: 10.5281/zenodo.213659
Pupation in drosophila melanogaster and the effect of the Lethalcryptocephal mutation

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract The events of normal pupation in Drosophila melanogaster are described in detail from the time of gas bubble expulsion until the completion of pupation with the eversion of the cephalic complex. The importance of the internal gas bubble for posterior movement of the prepupa is examined and its relation to the expulsion of the larval mouthparts and the creation of the anterior gas space described. The phenotype of lethalcryptocephal homozygotes, which characteristically cannot evert their heads, is re‐examined. Observations of larval lethality and multiple mouthparts in 1 (2)crc larvae and pupae are described. These new aspects of the mutant phenotype are discussed with respect to the abnormalities of pupation. Fristrom's hypothesis that the basic mutant lesion is an increased stiffness of the pupal cuticle due to an excess chitin deposition is re‐evaluated.
Aesthetic Computing and Shape

Field: Computer Science (Physical Sciences)

(Review of book in JVLC, 2007, and in Leonardo Reviews, Jan. 2007.)

In Aesthetic Computing, key scholars and practitioners from art, design, computer science, and mathematics lay foundations for a discipline that applies theory and practice of art to computing. Aesthetic computing explores way art and aesthetics can play a role in different areas of computer science. One of its goals is to modify computer science by application of wide range of definitions and categories normally associated with making art. For example, structures in computing might be represented using style of Gaudi or Bauhaus school. This goes beyond usual definition of aesthetics in computing, which most often refers to formal, abstract qualities of such structures--a beautiful proof, or an elegant diagram. The contributors to this book discuss broader spectrum of aesthetics--from abstract qualities of symmetry and form to ideas of creative expression and pleasure--in context of computer science. The assumption behind aesthetic computing is that field of computing will be enriched if it embraces all of aesthetics. Human-computer interaction will benefit--usability, for example, could refer to improving a user's emotional state--and new models of learning will emerge.Aesthetic Computing approaches its subject from a variety of perspectives. After defining field and placing it in its historical context, book looks at art and design, mathematics and computing, and interface and interaction. Contributions range from essays on art of visualization and the poesy of programming to discussions of aesthetics of mathematics throughout history and transparency and reflectivity in interface design.Contributors:James Alty, Olav W. Bertelsen, Jay David Bolter, Donna Cox, Stephan Diehl, Mark d'Inverno, Michele Emmer, Paul Fishwick, Monica Fleischmann, Ben Fry, Carsten Gorg, Susanne Grabowski, Diane Gromala, Kenneth A. Huff, John Lee, Frederic Fol Leymarie, Michael Leyton, Jonas Lowgren, Roger F. Malina, Laurent Mignonneau, Frieder Nake, Ray Paton, Jane Prophet, Aaron Quigley, Casey Reas, Christa Sommerer, Wolfgang Strauss, Noam Tractinksy, Paul Vickers, Dror Zmiri
A33 Traumatic brain injury

Field: Medicine (Health Sciences)

Background: In 2003 we introduced a standardized treatment protocol for patients with traumatic brain injury (TBI) treated in the intensive care unit (ICU). The aim of this study was to evaluate deviations from treatment goals for vital parameters and extracranial complications during the ICU stay after the introduction of the protocol. Patients and methods: 133 patients with severe TBI (GCS ≤ 8) were prospectively included during a five-year period (2004–2009). Deviations from treatment goals (blood pressure, haemoglobin, blood glucose, serum sodium, serum albumin, body temperature) and extra cranial complications during the ICU stay were registered. Outcome was measured as Glasgow Outcome Scale Extended (GOSE) at 12 months. Results: The patients admitted had a median age of 30 years (range 1- 81), median Glasgow Coma Scale (GCS) before intubation of 6 (range 3–8) and 26 % had uni-or bilateral pupil dilation on arrival at the hospital. 50 % were operated on for intracranial injuries. The deviations from the treatment goals were: hypotensive episodes (systolic BP < 90 mmHg): 20 %, anaemia (hgb ≤ 10 g/dl): 77 %, blood glucose ≥ 8 mmol/l: 43 %, serum sodium concentration ≤ 135 mmol/l: 35 %, serum albumin < 25 g/l: 31 % and hyperthermia (≥ 38° Celsius): 55 %. Of extracranial complications during the ICU stay pulmonary complications were most frequent (pneumonia 72 %, ARDS/ALI 32 %). Thrombocytopenia (4,5 %), severe sepsis (3 %), renal failure (0,8 %), and liver failure (0,8 %) were infrequent. A favorable outcome (GOSE 5–8) was seen in 57 % and an unfavorable outcome (GOSE ≤ 4) in 40 %, missing 4 (3 %). 27 (20 %) patients died within the first 12 months after the head injury. Age, GCS, pupil dilation, ICP > 25 mmHg and hyperglycaemia predicted an unfavorable outcome. Conclusions: Deviations from the TBI treatment protocol were frequent. Pneumonia was the most frequent extracranial complication.
Research Article Acceleration of Early-Photon Fluorescence Molecular Tomography with Graphics Processing Units

Field: Computer Science (Physical Sciences)

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fluorescence molecular tomography (FMT) with early-photons can improve the spatial resolution and fidelity of the reconstructed results. However, its computing scale is always large which limits its applications. In this paper, we introduced an acceleration strategy for the early-photon FMT with graphics processing units (GPUs). According to the procedure, the whole solution of FMT was divided into several modules and the time consumption for each module is studied. In this strategy, two most time consuming modules (G
The Non-similarity of Thermal Deformation in Asymmetrical Structures

Field: Engineering (Physical Sciences)

The phenomenon of thermal expansion and contraction of object is a natural rule that has a significant influence in engineering applications.In this paper,the thermal deformation experiments of the commonly used mechanical engineering machinery bearing hole has been carried on.Using self-developed experimental device,in the-10~80 ℃ temperature range,a single hole is measured accurately on the different radial directs,and measurement data are analyzed and combined with the structure and size of hole surrounding.The results show that the thermal deformation feature of hole is not only closely related to the physical attributes of material,but still affected by its own structure and size of parts.That means thermal deformation of parts has non-similar thermal deformation features,that is,when some shape parts have thermal deformation,the size and structure of parts all change to new status that is not similar to old shape of parts.
Gamnecourt in Picardy: Barbara de Bierle

Field: Arts and Humanities (Social Sciences)

Gamnecourt in Picardy: Barbara de Bierle Get access Scotus Scotus Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s11-II, Issue 52, 24 December 1910, Page 512, https://doi.org/10.1093/nq/s11-II.52.512a Published: 24 December 1910
Teacher Beliefs, Personal Theories and Conceptions of Assessment Literacy - A Tertiary EFL Perspective

Field: Arts and Humanities (Social Sciences)

The qualitative data was based on semi-structured interviews conducted with 12 tertiary EFL teachers working in 3 higher education institutes in the Easter Province of KSA. All required research ethical procedures before and after collecting data were followed. These included institutional and participant consent for data collection. Also, other ethical procedures such as participant anonymity, data confidentiality and data protection were ensured. The data was analyzed using thematic analysis approach, which included data reduction in the form of codes, subcategories, categories and themes.
Primary School Student Teachers' and Teachers' Satisfaction with Acquired Competences in Visual Arts Education

Field: Arts and Humanities (Social Sciences)

Student teachers’ and teachers’ satisfaction with acquired competences during studies is one of the important indicators of the quality of study programs and, in addition to their values, points also to their shortcomings. The research goal was to detect those visual arts areas in which students and teachers do (not) feel competent enough to teach visual arts, as well as to examine the level of student teachers’ and teachers’ satisfaction with acquired competences in the area of visual arts education. The results could help in designing better curriculum frameworks for visual arts education at Faculties of Teacher Education in Croatia. They should meet the contemporary needs of teachers and students, with the aim of successful implementation and the achievement of learning outcomes in visual arts education.