jimnoneill/paper-to-field-training huggingface dataset:
[Analysis of patients with locally advanced gastric cancer undergoing gastrectomy after pre-operative chemotherapy including S-1].

Field: Medicine (Health Sciences)

To improve the prognosis of advanced gastric cancer, various adjuvant therapies were tried. We retrospectively examined 7 cases of gastrectomy after pre-operative chemotherapy using S-1+CDDP, and reported its effectiveness and the result. An adverse event of more than Grade 3 showed neutropenia in two cases. Anti-tumor effect on the imaging was found in 6 cases of PR and one case of SD. We performed gastrectomy within 4 weeks after completion of chemotherapy in each case. The histological antitumor effect was more than Grade 2 in four cases, but there was no complete response. We compared the overall survival of a patient of more than Grade 2 by histological antitumor effect under grade 1b. In the former, MST was 982 days and the two-year survival rate was 50.0%; in the latter, MST was 443 days and the two-year survival rate was 33.3%. We can perform pre-operative chemotherapy using S-1+CDDP and expect prognostic improvement for a histologically effective case of chemotherapy. If the utility of preoperative chemotherapy mainly with S-1 is proved in a phase III trial, this would appear to be a therapy of choice for advanced gastric cancer in future.
Changes of Casein Complex in Sweetened Condensed Milk during Storage

Field: Agricultural and Biological Sciences (Life Sciences)

脱脂加糖練乳の貯蔵(40C)中のカゼイン複合体の変化を主としてゲル〓過およびポリアクリルアミドゲル電気泳動(PAGE)で調べた.その結果,尿素溶液のみでゲル〓過を行った場合は貯蔵日数の増加にともない高分子量画分の量が増加し,またメルカプトエタノールを含む尿素溶液でゲル〓過を行った場合には貯蔵0,10,30日では高分子量画分の量は著しく減少したが,貯蔵60日のものにはかなりの量の高分子量画分の存在が認められた.また,PAGEでは貯蔵日数の増加にともないαs1-カゼインに相当するバンドが薄くなり,かつβ-カゼインに相当するバンドと原点の間に広く分散したバンドが出現,増加するのが認められた.以上の結果から加糖練乳貯蔵中にカゼインには-S-S-結合の関与する会合,およびそれ以外のたとえばアミノカルボニル反応の関与による高分子化などの変化が生じていることが示唆された.
Emerging space tourism business: Uncovering customer avoidance responses and behaviours

Field: Business, Management and Accounting (Social Sciences)

Space travel involves complicated processes, and the potential tourists may avoid these trips at any stage due to various risks and costs. The avoidance intention has serious implications for both the tourists and the services. Applying a push-pull-mooring (PPM) framework, we modelled space tourist’s avoidance intention. We developed a model that investigates the direct effect of the push, pull, and mooring factors on avoidance intention. We evaluated the moderation role of the mooring factor with the associations of the push and pull factors with the avoidance intention. We also assessed the necessity of the push, pull, and mooring factors with avoiding space tourism. Using configurational modelling, we explored algorithms that explain the conditions where tourists avoid space tourism. Space tourism avoidance intention is increased by the push factor and decreased by the push and mooring factors. The mooring factor moderates the impact of the pull factor on the avoidance intention.
Tensor to scalar ratio and large scale power suppression from pre-slow roll initial conditions

Field: Physics and Astronomy (Physical Sciences)

We study corrections to the power spectra of curvature and tensor perturbations and the tensor-to-scalar ratio in single field slow roll inflation due to initial conditions imprinted by a fast-roll stage prior to slow roll. For a wide range of initial inflaton kinetic energy, this stage lasts only a few e-folds and merges smoothly with slow-roll leading to non-Bunch-Davies initial conditions for modes that exit the Hubble radius during slow roll. We describe a program that yields the dynamics in the fast-roll stage while matching to the slow roll stage independent of the inflationary potentials. Corrections to the power spectra are encoded in a transfer function $\mathcal{T}_\alpha(k)$. We obtain $\mathcal{T}_\alpha(k)$ to leading order in a Born approximation valid for modes of observational relevance today. A fit yields $\mathcal{T}_\alpha(k) =1+ A_{\alpha}k^{-p}\cos[2\pi \omega k/H_{sr}+\varphi_\alpha]$, with $1.5 \lesssim p \lesssim 2$, $\omega \simeq 1$ and $H_{sr}$ the Hubble scale during slow roll inflation, where curvature and tensor perturbations feature the same $p,\omega$ for a wide range of initial conditions. These corrections lead to both a suppression of the quadrupole and oscillatory features in both $P_R(k)$ and $r(k_0)$ with a period of the order of the Hubble scale during slow roll inflation. The results are independent of the specific inflationary potentials, depending solely on the ratio of kinetic to potential energy $\kappa$ and the slow roll parameters to leading order. For a wide range of $\kappa$ and the values of $\epsilon_V;\eta_V$ corresponding to the upper bounds from Planck, we find that the low quadrupole is consistent with the results from Planck, and the oscillations in $r(k_0)$ could be observable if the modes corresponding to the quadrupole and the pivot scale crossed the Hubble radius a few e-folds after the onset of slow roll.
Data Corroboration of The Catastrophic Chernobyl Tragedy Using Arc-Length Estimate Conjecture

Field: Mathematics (Physical Sciences)

Nuclear power is perhaps one of the biggest keys to empowerment for any country. In fact, nuclear power has been the backbone of the international superpowers like the US and USSR since the 20th Century. Alongside its merits, nuclear power carried some demerits propping on it. One of the biggest amongst all was the Chernobyl nuclear cataclysm that occurred on the 26’th April 1986. Within hours of the explosion, nuclear radiation blanketed the whole city of Pripyat, Ukraine. In this paper, we have developed a notion namely “Arc-Length Estimate Conjecture” to detect anomaly, and fairness in data sets. If an anomaly is found, the Arc Length Estimate Conjecture is capable of dissecting the anomality in magnitudical terms. Further we have analyzed the Radiation that emerged from the Chernobyl Catastrophe by looking at the concentration of radioactive elements that were measured from different parts of the world. We have considered the elements I131 and Cs134 as elements of utmost importance and have tried to verify the data put forward by USSR regarding the radiation emission level of these radio actives. social-circles, and non-religious students. The results of this study and related studies to follow will be used to inform improvements to mental health counseling and outreach to at- risk individuals at universities across the United States.
Elucidation of the chondrogenic gene regulatory network controlling embryonic skeletal development.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

More than 90% of the skeleton in the developing mammalian embryo is formed via endochondral ossification which requires an obligatory cartilage intermediate as a template for bone formation, making chondrogenesis an essential pathway during development. Sox5, Sox6, and Sox9 were uncovered via classical genetic analyses of human diseases and mouse models to be the key transcription factors controlling chondrogenesis. The knowledge behind the regulation of the Sox proteins and the genes they regulate in vivo is still in its infancy. In this study by merging classical mouse genetics with advanced technology, transcriptome profiling and chromatin immunoprecipitation sequencing for the Sox trio were carried out in the mouse at E13.5 for the first time to gain insight to what is happening in the context of a developing embryo. From the analysis of the data generated, a novel high-confident chondrogenic gene regulatory network at E13.5 was built.
Interviewing children for the purposes of research in primary care

Field: Health Professions (Health Sciences)

Interviewing can provide unique opportunities for professionals to gain some understanding of the child's subjective experience, where other means of data collection are inappropriate and other sources of data are less valid. This article is concerned with the principles and practicalities of interviewing children for the purposes of health-related research. It draws on the knowledge gained from three decades of research involving interviewing young people in many contexts, including health care, social welfare and child protection. A conceptual framework is presented to illustrate the interactive and iterative processes that occur between interviewer and interviewee, and the pivotal importance of context in shaping any interaction. The influences of the young person's linguistic, cognitive and social skills are discussed. The effects of the gender and ethnicity of both the researcher and the researched are considered in relation to the conduct of the interview, and the influence of adult biases and perspectives on the evaluation and interpretation of data is explored.
Cost-Effective Viral Marketing for Time-Critical Campaigns in Large-Scale Social Networks

Field: Computer Science (Physical Sciences)

Online social networks (OSNs) have become one of the most effective channels for marketing and advertising. Since users are often influenced by their friends, "word-of-mouth" exchanges, so-called viral marketing, in social networks can be used to increase product adoption or widely spread content over the network. The common perception of viral marketing about being cheap, easy, and massively effective makes it an ideal replacement of traditional advertising. However, recent studies have revealed that the propagation often fades quickly within only few hops from the sources, counteracting the assumption on the self-perpetuating of influence considered in literature. With only limited influence propagation, is massively reaching customers via viral marketing still affordable? How do we economically spend more resources to increase the spreading speed? We investigate the cost-effective massive viral marketing problem, taking into the consideration the limited influence propagation. Both analytical analysis based on power-law network theory and numerical analysis demonstrate that the viral marketing might involve costly seeding. To minimize the seeding cost, we provide mathematical programming to find optimal seeding for medium-size networks and propose VirAds, an efficient algorithm, to tackle the problem on large-scale networks. VirAds guarantees a relative error bound of O(1) from the optimal solutions in power-law networks and outperforms the greedy heuristics that realizes on the degree centrality. Moreover, we also show that, in general, approximating the optimal seeding within a ratio better than O(logn) is unlikely possible.
LAPTM5 Plays a Key Role in the Diagnosis and Prognosis of Testicular Germ Cell Tumors

Field: Medicine (Health Sciences)

Objective. Testicular germ cell tumors (TGCT) are a serious malignant tumor with low early diagnosis rates and high mortality. Methods. To investigate novel biomarkers to predict the diagnosis and prognosis of this cancer, bioinformatics analysis was used as an accurate, efficient, and economical method. Results. Our study detected 39 upregulated and 589 downregulated differentially expressed genes (DEGs) using the GEO and TCGA databases. To identify the function of DEGs, GO functional analysis, three pathway analysis (KEGG, REACTOME, and PANTHER), and protein-protein interaction network were performed using the KOBAS website, as well as the String database. After a series of analyses in GEPIA and TIMER, including differential expression, we found one candidate gene related to the prognosis and diagnosis of TGCT. LAPTM5 was also associated with CD8+ T cell and PDCD1 expression, which suggests that it may affect immune infiltration. Conclusions. LAPTM5 was identified as a hub gene, which could be used as a potential biomarker for TGCT diagnosis and prognosis.
In vitro study of antioxidant, antigylycation, sugar hydrolysis enzyme inhibitory effect and molecular in silico docking study of angularly condensed diquinothiazines

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Angularly condensed diquinothiazines (MY1, MY2, and MY3) a phenothiazine derivative was evaluated for antioxidant, antiglycation, sugar hydrolysis enzyme inhibitory effect and molecular in silico docking. Antioxidants were evaluated using DPPH, chelating ion, FRAP and lipid peroxidation. Alpha glucosidase and alpha amylase inhibition was used for sugar hydrolysis enzyme inhibitory activity and antiglycation with BSA-Glucose and BSA-MGO. In silco docking was done with AutoDock Vina and ADMET properties with pkCSM software. Angularly condensed diquinothiazines (MY1, MY2, and MY3) showed free radical scavenging, antiglycation and alpha-glucosidase and alpha-amylase inhibition. Insilco docking and pkCSM ADME shows interaction with aldose reductase, glyoxalase 1, receptor AGE, alpha-glucosidase, and alpha-amylase. Antiglycation, alpha-glucosidase, and alpha-amylase inhibition activity of Angularly condensed diquinothiazines maybe through deactivation of aldose reductase enzyme activity, activation of glyoxalase 1 pathway, reduction of dicarbonyl stress and oxidative stress.
The Performance Implications of Participating in an Acquisition Wave: Early Mover Advantages, Bandwagon Effects, and The Moderating Influence of Industry Characteristics and Acquirer Tactics

Field: Business, Management and Accounting (Social Sciences)

Acquisitions often occur in waves within industries. We extend the theoretical understanding of such waves by drawing upon research on early mover advantage and bandwagon effects to develop arguments regarding the likely performance potential of participating at different points in an acquisition wave. In line with our theoretical model, we find acquisition performance is higher for early movers but lower for acquirers that participate at the height of the acquisition wave. Although we find this general performance trend, our findings suggest both industry and acquirer characteristics influence the degree to which firms seize early mover advantages or fall prey to bandwagon pressures.
Gingival Disease - A Professional Approach for Treatment and Prevention

Field: Dentistry (Health Sciences)

Gingival diseases interact with many systemic disturbances and can adversely affect a person's quality of life. Therefore an accurate diagnosis with successful treatment and prevention is necessary to mitigate negative consequences and improve the outcome of dental therapy. This book uncovers the hidden causes of many recurrent gingival and oral illnesses, and helps guide the dental professional to diagnosis. By highlighting the importance of gingival treatment and prevention, and then discussing the correlation between gingival and systemic diseases through an academic and professional approach, the book provides the dental practitioner with precise information for treating and managing difficult cases related to systemic diseases. This volume will help both the dentist and the patient to be more satisfied with dental and gingival therapy.
Cytoplasmic accumulation of ELAVL1 is an independent predictor of biochemical recurrence associated with genomic instability in prostate cancer

Field: Medicine (Health Sciences)

Background ELAVL1 is an RNA binding protein involved in translation control, which might have a regulatory role in prostate cancer progress. Methods To evaluate its impact and relationship with key genomic alterations, ELAVL1 expression was analyzed by immunohistochemistry on a tissue microarray containing 12,427 prostate cancers. Results The analysis revealed a mild to moderate predominantly nuclear immunostaining in normal prostate epithelium and an often higher both cytoplasmic and nuclear expression in cancer cells. Weak, moderate, and strong cytoplasmic ELAVL1 staining was found in 43%, 18%, and 3% of 10,478 interpretable tumors. Strong ELAVL1 staining was linked to high Gleason grade, advanced pathological tumor stage, positive nodal status, and PSA recurrence ( P < 0.0001 each). A combined analysis of the effect of nuclear and cytoplasmic ELAVL1 expression on PSA recurrence revealed that the association with patient outcome was entirely driven by cytoplasmic staining. ELAVL1 positivity was more frequent in cancers harboring TMPRSS2:ERG fusions found by FISH (78%) or showing immunohistochemical ERG expression (74%) than in cancers without ERG rearrangement (63%) or ERG expression (58%, P < 0.0001 each). Strong cytoplasmic ELAVL1 staining was further linked to presence of PTEN , 5q21, 6q15, and 3p13 deletions ( P < 0.0001 each), an observation consistent with cytoplasmic ELAVL1 accumulation in case of genomic instability. The prognostic role of ELAVL1 expression was independent of Gleason grade, T stage, N stage, surgical margin status, and preoperative PSA, irrespective of whether preoperative or postoperative variables were used for modeling. Conclusion Our study identifies cytoplasmic accumulation of ELAVL1 as a predictor of adverse clinical behavior of prostate cancer independent of established clinico‐pathological parameters. Prostate 76:259–272, 2016 . © 2015 Wiley Periodicals, Inc.
Acute Appendicitis in Childhood

Field: Medicine (Health Sciences)

BRDISH 1129 enough to keep him awake at night.He had some frequency of micturition but no dysuria, and his pain was aggravated by coughing and deep breathing.On examination his temperature was 101.8°F. (38.8°C.), pulse 96, respiration 20.The W.B.C. count was 11,200 (90% neutro- phils).The E.S.R. was 22 mm. in the first hour.The urine was acid in reaction and contained neither protein nor pus cells and yielded no significant bacterial growth on culture.A nose swab grew Staph.pyogenes.An x-ray of chest and left ribs showed no abnormality.A blood culture also grew Staph.pyogenes.The only abnormal physi- cal signs were tenderness in the left loin, renal angle, and over the left lower ribs, posteriorly with obvious swelling in the same regions.The temperature remained around 104°F.
Impact of humor and gender in e-mail marketing : Case DefShop GmbH

Field: Business, Management and Accounting (Social Sciences)

This Bachelor’s thesis project was conducted for DefShop GmbH. In accordance to the commissioner’s interests towards customization of their e-mail newsletter service, a test campaign was administered in order to detect possible differences in the clicking behavior of male and female newsletter subscribers when receiving either neutral or humorous e-mails. The two test e-mails used for the campaign differed in their visual content, changing the message in either humorous or neutral direction. The click rates of both versions were examined in reference to the humor condition applied and the gender of the subject. \n \nThe hypotheses were that male subscribers would react more strongly to the humorous e-mail version, whereas female subscribers would not be affected by the amount of humor in the newsletter. Data analysis was conducted through exploratory analysis, contingency tables with Chi-Square tests, and binary logistic regression model. Hypotheses about gender variations were evaluated based on the analysis results. \n \nThe theoretical framework of the thesis consists of an overview of an analysis of the e-commerce field, online marketing, more specifically e-mail as a marketing channel, and humor in advertising context. Previous research results on the subject of observed gender-based differences in the effect of humorous advertisement, which found males to be more likely to react to humorous advertisement, while females were not affected by the humor condition, were used as a basis for the hypothesis formation. \n \nThe results of the research analysis were not entirely conclusive. Although the hypotheses were found to apply to the population at hand, no statistically inconclusive proof emerged that there would be significant interaction effect between humor and the gender. As a result, it could not be concluded that the observed differences between genders’ click-rates were directly linked to the presence of humor. As the different statistical methods yielded partly incoherent results, no statement can be made that gender would be a determining factor of click-tendency in different humor condition groups. Further research points on the subject were suggested to the commissioner based on the analysis.
The Effect of an Enhanced Geriatrics Curriculum on Medical Students' Knowledge: A Cohort Study

Field: Health Professions (Health Sciences)

BACKGROUND: Medical schools across the nation have turned attention to strengthening their curricula in geriatric medicine to prepare students for an aging nation. Effects of enhanced curricula need to be evaluated for program monitoring and continuous improvement.OBJECTIVE: To evaluate the effect of an enhanced geriatrics curriculum on medical students’ knowledge.DESIGN: Longitudinal cohort studies with cross-sectional historical comparisons.PARTICIPANTS: The Class of 2005 students (n = 150) and a random sample of the Class of 2001 students (n = 43) as a historical control with the control group received a lesser amount of geriatrics training.MEASUREMENTS: A validated 18-item geriatrics knowledge test assessing medical students’ knowledge about aging (6 items) and clinical geriatric management (12 items) was administered to the Class of 2005 students at the baseline and end of years 1, 2, and 3, and to the Class of 2001 students at the end of year 4.RESULTS: The Class of 2005 students demonstrated a significant increase in the number of items answered correctly (M = 35% to M = 75%, p &lt; .001) and a significant decrease in the number of items answered “Don’t Know” (M = 44% to M = 5%, p &lt; .001). The cohort also showed a better performance at the end of year 3 (M = 75%) than the fourth-year control group (M = 71%, p = .009).CONCLUSIONS: The enhanced geriatrics curriculum demonstrated an effect on improving medical students’ geriatrics knowledge.
Spawning response latency and egg production capacity of LHRHa-injected mature female sea bass, Lates calcarifer Bloch

Field: Agricultural and Biological Sciences (Life Sciences)

Mature female sea bass (Lates calcarifer Bloch) were injected once intramuscularly with 20 μg luteinizing hormone-releasing hormone analogue (D-Ala6, Pro9-LHRH-ethylamide) per kg body weight (BW) at different times of the day. Following hormone injection, the incidence of initial spawning and the number of eggs spawned by each fish were recorded. Saline-injected fish did not spawn. Fish spawned at dawn or 33.7–40 h after an LHRHa injection at either 11.00 h or 17.00 h. When LHRHa was administered at 23.00 h or 05.00 h, sea bass spawned during the day or at 38–47.3 h post-injection. Mean egg production levels of 26.8–34.4 × 104 per kg BW were higher for fish which spawned at dawn. Low mean egg production levels (6.2–19.9 × 104 eggs per kg BW) were observed when LHRHa-injected fish spawned during the day. These results demonstrate that the time of initial occurrence of spawning varied with the time of day that LHRHa was administered and that the number of eggs shed was influenced by the time of day that hormone-induced sea bass spawned.
The Protection of the Procedural Rights of Persons Concerned by OLAF Administrative Investigations and the Admissibility of OLAF Final Reports as Criminal Evidence

Field: Social Sciences (Social Sciences)

This paper provides an analysis of two crucial and interconnected aspects of the current legal framework on the investigations conducted by the European Anti-Fraud Office (OLAF): the procedural safeguards for the individuals subject to the administrative investigations conducted by OLAF and the admissibility in evidence of OLAF Final Reports in national criminal proceedings. The state of the art and its shortcomings are analysed in the double perspective of the coherent protection of the EU’s financial interests and of the respect of fundamental rights provided by the EU Charter of Fundamental Rights.