jimnoneill/paper-to-field-training huggingface dataset:
The Insulin Receptor Substrate 1 Associates With Phosphotyrosine Phosphatase Shptp2 In Liver And Muscle Of Rats.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Insulin stimulates the tyrosine kinase activity of its receptor resulting in the phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1) which, in turn, associates with proteins containing SH2 domains. It has been shown that IRS-1 associates with the tyrosine phosphatase SHPTP2 in cell cultures. While the effect of the IRS-1/SHPTP2 association on insulin signal transduction is not completely known, this association may dephosphorylate IRS-1 and may play a critical role in the mitogenic actions of insulin. However, there is no physiological demonstration of this pathway of insulin action in animal tissues. In the present study we investigated the ability of insulin to induce association between IRS-1 and SHPTP2 in liver and muscle of intact rats, by co-immunoprecipitation with anti-IRS-1 antibody and anti-SHPTP2 antibody. In both tissues there was an increase in IRS-1 association with SHPTP2 after insulin stimulation. This association occurred when IRS-1 had the highest level of tyrosine phosphorylation and the decrease in this association was more rapid than the decrease in IRS-1 phosphorylation levels. The data provide evidence against the participation of SHPTP2 in IRS-1 dephosphorylation in rat tissues, and suggest that the insulin signal transduction pathway in rat tissues is related mainly to the mitogenic effects of the hormone.
‘War Cry’ or War Atrocity? A Note on Sinuhe B 140

Field: Arts and Humanities (Social Sciences)

Virtually all translators render wd.n=i išnn ḥr i3t=f in Sinuhe B 140 as ‘I raised a/my war/victory cry ( išnn) over the back’ of the nḫtw of Retenu. The author argues instead that išnn is an imperfective participial form derived from the verb šni, ‘to conspire/curse’, with the verbal noun being a term of execration applied to the rebellious nḫtw. Sinuhe’s action of ‘putting’ ( wdi) the condemned conspirator ( išnn) ‘on his back’ points to the victor’s display of his disgraced opponent’s corpse.
Gregor Mendel’s meeting with Pope Pius IX: the truth in the story.

Field: Arts and Humanities (Social Sciences)

According to Hugo Iltis, Mendel had made a journey to Italy in the 1860s, not knowing when or for \nwhat purpose. Mendel might then have also paid a visit to Pope Pius IX, and become acquainted \nwith the “later” Cardinal Teodolfo Mertel. Oswald Richter had already discovered that Mendel had \nreceived a 3-months pass for the Italian states in mid-August 1863. In this article, I put forward new \nevidence and arguments that it is very likely that Mendel took part in a three weeks’ organized \ngroup tour to Italy in September 1863. This tour was organized by the same entrepreneurs as \nMendel’s group tour to the International Exhibition in London a year earlier. In Rome, the group was \nreceived by the Pope. Furthermore, there were stays of several days in Naples and Florence. \nBecause Mertel had already become Cardinal four years before this trip, this part of the story about \nMertel cannot be correct. I argue that it is likely that the high dignitary whom Mendel met was Karl \nvon Hefele, professor of church history, spokesman for the group at the meeting with the Pope. It is \nstriking that in 1862 and 1863, Mendel could make expensive international trips, which were only \naffordable to the societal elite. These major international journeys illustrate Mendel’s broad interest \nin the world and the society of his days and contrast the view that he was a monk in recluse.
US DOL regulations may challenge private investment funds

Field: Business, Management and Accounting (Social Sciences)

Purpose The purpose of this paper is to analyze recent regulations and proposed regulations issued by the US Department of Labor (DOL) that relate to the reporting of compensation paid to service providers to employee benefit plans. Design/methodology/approach The paper reviews the statutory provisions of the Employee Retirement Income Security Act of 1974, as amended (ERISA), applicable DOL regulations as available in the Federal Register and certain public comments and a DOL FAQs document regarding the applicable regulations available on the DOL's web site. The paper also relies on observations of common market practice based on actual experience. Findings Recent DOL regulations – in particular those related to Form 5500 reporting and the “Necessary Services Exemption” – may significantly affect the reporting obligations of certain private investment fund sponsors with respect to their employee benefit plan investors. It shows that, although the scope of these regulations is understandable in the context of participant‐directed defined contribution plans, they may be less so in the context of defined benefit plans, which invest more frequently in private investment funds. There are some potential exceptions, on which private investment fund sponsors may be able to rely. Achieving compliance with the rules as drafted, however, may be time‐consuming and costly. Practical implications Private investment fund sponsors may wish to begin looking at their compensation and service provider arrangements in light of these regulations and consider how best to respond. Originality/value The paper contains two experienced ERISA practitioners' analysis of recent regulations on which relatively few stakeholders have seemed to focus to date.
Estimating HIV levels and trends among patients of tuberculosis clinics.

Field: Medicine (Health Sciences)

Symptomatic tuberculosis (TB) can occur as an opportunistic disease in immunosuppressed persons who are infected with human immunodeficiency virus (HIV) and who have been previously infected with Mycobacterium tuberculosis. Increases in TB cases have occurred in areas which have reported large numbers of cases of the acquired immunodeficiency syndrome (AIDS), and a high proportion of these TB cases have been HIV seropositive. Therefore, increasing numbers of HIV-infected persons may be found in TB clinics and hospitals. HIV serologic surveys in TB clinics and hospitals providing clinical services to TB patients are needed to assess the local prevalence of HIV infection in TB patients and the consequent need for public health intervention to prevent further spread of HIV and TB infection. The Centers for Disease Control (CDC), in collaboration with State and local health departments, has initiated HIV surveillance of patients with confirmed and suspected TB in TB clinics and hospitals in the United States. Blinded (serologic test results not linked to identifiable persons) HIV seroprevalence surveys are conducted in sentinel TB clinics and hospitals that provide TB clinical services each year to obtain estimates of the level of HIV infection in TB patients and to follow trends in infection over time. Nonblinded (voluntary) surveys will also be conducted to evaluate behaviors that have placed TB patients at risk for or protected them against HIV infection. Data from these surveys will be used to target education and prevention and control programs for TB and HIV infection and to monitor changes in behavior in response to such programs.
ORTHOTOPIC PARTIAL LIVER TRANSPLANTATION IN THE RAT

Field: Medicine (Health Sciences)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Online FirstCurrent IssuePrevious IssuesSupplements Editor's Picks Current Editor's PicksArchived Editor's Picks Collections COVID in TransplantationXenotransplantationTop Altmetric ArticlesTop 100 Articles in TransplantationFree AccessSocial MediaHand and Composite Tissue TransplantationRandomized Control TrialsAntibody Mediated RejectionBelatacept Mediated Costimulation BlockadeTTS Guidelines and Updates from the Vancouver CongressHumoral Autoimmunity and Transplant VasculopathyBiomarkersView All Social Media VideosVisual Abstracts For Authors Submit a ManuscriptInformation for AuthorsOpen AccessLanguage Editing ServicesAuthor PermissionsLippincott® Preprints Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and PermissionsTransplantation DirectReviewer Thank You All Articles Images Videos Podcasts Blogs Advanced Search
The Separation and Identification of Pig Pseudo Hydrophobic Virus

Field: Veterinary (Health Sciences)

We separated a suspected pseudo rabies virus(PRV) strain from some sick pigs' brain tissue in a Shanxi piggery,and identified it by the BHK-21 cell culture,virus toxic titration,neutralization test,and PCR detection method of the virus.The results were that: The separated virus had typical cytopathy in BHK-21 cell culture blind passage after four generations;Using BHK-21 cells determination,the poison price of TCID50 10-8.042/0.1 mL was got;By polymerase chain reaction(PCR) expand in vitro could see its amplification clips in line with the expected purpose segment strip;According to the above characteristics of separated strains,the pig pseudo hydrophobic virus was identified and named as SX09.
Ehrharta setacea subsp. uniflora (64115)

Field: Agricultural and Biological Sciences (Life Sciences)

Kingdom: Plantae
Division: Magnoliophyta
Class: Monocots
Order: Poales
Family: Poaceae
Scientific name: Ehrharta setacea subsp. uniflora (Burch. ex Stapf) Gibbs Russ.
Specimen barcode: 64115
Importancia de las competencias en la formación de enfermería

Field: Health Professions (Health Sciences)

Objective: The study was designed to find out how nursing professionals and interns at the Universidad Mayor de Chile Nursing School in 2008 felt about the importance of professional competences in training students for professional practice. Method: The authors performed a cross-sectional descriptive study. Data collection was done through a self-administered survey among two groups: interns and nurses. Descriptive statistics were used for data analysis. The results show the groups surveyed appreciate the fact that care-giving, general, educational and hallmark competences are "very important for professional development�. However, the degree of importance varies depending on the function performed by the respondents. Conclusion: The study enabled graduates and professionals to validate the skills students acquire as part of their university education, which respond to the demands of the job and provide an opportunity for professionals to become involved in academic management.
First record of nine Fusarium spp. causing root rot on wheat (Triticum aestivum L.) in Iraq

Field: Agricultural and Biological Sciences (Life Sciences)

Nine Fusarium species have been isolated from wheat roots displaying disease symptoms on seven wheat cultivars planted in 13 fields distributed on six districts at Basra province. Each Fusarium species with different isolates had been morphologically identified to genus level and molecularly to species level by using translation elongation factor 1- α (tef1- α) sequencing. Results of pathogenicity test showed that the effects of the majority of nine tested Fusarium species were significant (P ≤ 0.05 to P ≤ 0.01) for causing Fusarium root rot (FRR). F. pseudograminearum had the highest level of FRR disease severity (72.1%), while F. nygamai was the lowest (16.11%) on Research 22 (Res. 22) cultivar. Analysis of seed and seedling tests of Res. 22 cultivar showed that the interaction between Fusarium spp. and seed germination was not significant (P>0.05), except F. pseudograminearum, F. culmorum and F. cerealis that had significant (P ≤ 0.05) effect with (40, 43 and 47) % respectively. While, the interaction between Fusarium spp. and seedling survival was significant (P ≤ 0.05 to P ≤ 0.01) for most measurements taken, except F. chlamydosporum had no effect on development of surviving plants. The results of this study indicate that this is the first study identifying FRR on wheat plants in Iraq.
A Study of Transportation Disruption Causes and Costs in Containerized Maritime Transportation

Field: Decision Sciences (Social Sciences)

This research focuses on estimating and understanding the costs and causes of transportation related supply chain disruptions. In-depth interviews with logistics managers were undertaken to investigate how companies perceive transportation related supply chain disruptions and what they are doing to respond and address them. Stated choice experiments were designed to estimate the cost of disruptions for containers in international maritime trade. The results of the discrete choice models indicate that disruption costs are several times larger than traditional values of freight travel time and reliability.
Innovation through Niche Tourism Development in the Post-industrial Economy

Field: Social Sciences (Social Sciences)

The paper analysis the role of niche tourism development in providing an alternative to traditional industries in post-industrial economies. Since mass tourism development may bring about serious negative social, economic and environmental consequences, and as industrial communities often lack the traditional geographical and heritage resources of conventional tourism development, the growth of tourism in post-industrial areas is usually based on creativity and innovation in identifying potential niche products and catering for niche visitor segments. \nThe research presented in the paper analyses the case of Székesfehérvár, Hungary, an urban destination in transformation.
Holographic Entanglement Entropy and Confinement

Field: Physics and Astronomy (Physical Sciences)

We study the phase transition in the holographic entanglement entropy for various confining models. This transition occurs for the entanglement entropy of a strip at a critical value of the strip width. Our main interest is to examine the critical width for models with several parameters. For these models, the critical width, the glueball mass and the string tension all become functions of these two parameters. Comparing the behavior of the critical width in the entanglement entropy and these other scales, we find that $l_c$ seems to follow closely the deconfinement temperature and the glueball mass. The behavior of the string tension is similar to $l_c$, despite of being parametrically smaller than the other quantities.
Psychosocial factors associated with migraine and tension-type headache in medical students

Field: Medicine (Health Sciences)

Background In our previous study of workers, blood donors and medical students, students stood out with a higher 1-year prevalence of migraine (28%) and tension-type headache (TTH) (74%). General factors associated with headache were common for all groups except low physical activity. The hypothesis of this study was therefore that a number of psychosocial factors relating to the personal sphere would better explain the high prevalence of migraine and TTH in students. Methods The study population consisted of 1042 students (719 females, 323 males, mean age 20.6, range 17–40). Headache diagnoses and associated factors were identified by direct professional semi-structured interview. We also interviewed about the following psychosocial factors: dissatisfaction with study, dissatisfaction with family life, dissatisfaction for personal reasons, bad financial situation, overwork, stress, not enough sleep, insomnia, depressed mood, anxiety, irritability, tendency towards conflicts and not being married. We report psychosocial factors associated with headache according to diagnosis and sex using univariate and multivariate logistic regression analyses. Results Several factors were significantly associated with migraine and TTH in the univariate analysis. In the multivariate analysis, two psychosocial factors were statistically significantly associated with migraine in all students: irritability (OR 2.2, 95% CI 1.4–3.6) and overwork (OR 2.2, 95% CI 1.4–3.5). Insomnia (2.7, 95% CI 1.1–6.9) and depressed mood (OR 2.1, 95% CI 1.1–4.2) were associated with migraine only in females. Two psychosocial factors were associated with TTH: dissatisfaction with study in males (OR 2.0, 95% CI 1.0–3.8) and depressed mood in females (OR 1.8, 95% CI 1.0–3.5). Conclusion Psychosocial factors from the personal sphere showed significant association with migraine and TTH in students. Such factors should therefore be major targets for preventive efforts to reduce the prevalence of primary headache disorders in students.
Wind tunnel study of cruciform parachutes folded in various configurations

Field: Engineering (Physical Sciences)

As part of the US. Air Force New World vistas Precision Aerial Delivery program, a series of wind tunnel tests was initiated to study the feasibility of a “drogue-to-main” crutiorm parachute concept, to be used in ballistic cargo drops of the HALO type. The drogue-to-main concept consists in using the main parachute as a drogue, by deploying it Srst in a folded or reefed cort@uratior~ which allows a stable, but rapid descent of the payload. Near its intended landing point, the main is then allowed to unfold at a preset altitude. The main attraotions of this concept resides in its simplicity and weight savings that result in using only one parachute system to carry out two important phases of a cargo airdrop. In the following we present results collected during wind tunnel tests ofthe drogue-to-main. concept as applied to cruciform parachutes. Such tests were aimed at first iden@ing the best folded/reefed conf&m-ations according to its total drag and stability, and by its unfolding ease during the drogue-to-main transition. We also present the results of drop tests of the same tunnel models performed from a manned flying sport parachute. These test were aimed at gathering “open a?’ data needed for tunnel blockage correction of tunnelgathered data. *Member AIAA * Student Member AIAA Copyright @ 1999 by the American Institute of Aeronautics and Astronautics. All rights reserved.
Canine Hippocampal Formation Composited into Three-Dimensional Structure Using MPRAGE

Field: Neuroscience (Life Sciences)

This study was performed to anatomically illustrate the living canine hippocampal formation in three-dimensions (3D), and to evaluate its relationship to surrounding brain structures. Three normal beagle dogs were scanned on a MR scanner with inversion recovery segmented 3D gradient echo sequence (known as MP-RAGE: Magnetization Prepared Rapid Gradient Echo). The MRI data was manually segmented and reconstructed into a 3D model using the 3D slicer software tool. From the 3D model, the spatial relationships between hippocampal formation and surrounding structures were evaluated. With the increased spatial resolution and contrast of the MPRAGE, the canine hippocampal formation was easily depicted. The reconstructed 3D image allows easy understanding of the hippocampal contour and demonstrates the structural relationship of the hippocampal formation to surrounding structures in vivo.
Insights of inhibition mechanism of sifuvirtide and MT-sifuvirtide against wild and mutant HIV-1 envelope glycoprotein41: a molecular dynamics simulation and binding free energy study

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Sifuvirtide (SFT) is the second generation inhibitor of HIV-1 gp41 fusion protein, which is under phase III clinical trial for anti-HIV. However, over a period of time virus develops resistance against SFT. To overcome resistance, methionine and threonine (MT) amino acids were implemented in the pocket binding domain of SFT namely MT-Sifuvirtide (MTSFT), which have more helicity; higher melting temperature and stability against resistance-virus. To date, the binding stability and functional role of MT-hook against wild type and mutant form of HIV-1 gp41 fusion protein are not known. In the present study, SFT and MTSFT were individually docked with the wild and V10A/A19I/Q24R mutant form of HIV-1 gp41. Further MD simulation was carried out to understand the stability of the ligand–protein complexes. The free energy values were calculated from the MD trajectories to understand the effect of mutation involved in the binding process. MD results revealed helix to loop type conformational changes in N-heptad repeat (NHR) of gp41 due to mutation. Intermolecular interactions reveal that MTSFT forms more strong interactions with NHR of gp41 than SFT, which is critical for six-helix bundle stabilisation. Hence, the results explained the detailed functional role of MT-hook against gp41 fusion at the molecular level.
An Evidence Based Approach to Identifying Competencies for a Medical Curriculum: A Proposal Based on Medico-Legal Practice in Sri Lanka

Field: Health Professions (Health Sciences)

Criteria for including content into undergraduate curricula should not be based purely on the enthusiasm of teachers. What is taught at undergraduate level should be based on the needs and expectations of society from medical graduates and therefore be evidence based. Forensic Medicine training at undergraduate level, in Sri Lanka was selected as an example of this proposed method. Forensic Medicine training at undergraduate level, in Sri Lanka, is not based on a formal process of needs assessment. It is not linked to the key priorities of the the ministry of justice (service recipient) or the ministry of health (service provider). The links between these institutions need to be utilised maximally in a formal way for workforce training and development. Unless this task is approached thoughtfully and systematically the curriculum would merely be a reflection of faculty interest rather than of stakeholder, student or public needs. This paper highlights a needs based approach that maybe utilized in developing a medico legal curriculum which can be applied in the development of curricula in other disciplines.
Remuneration Policy as a Key Determinant Factor Motivating Togolese Healthcare Employees

Field: Health Professions (Health Sciences)

Motivating high levels of employee performance is an important organizational consideration. Both academic researchers and practicing managers have been trying to understand and explain employee motivation for years. Then, supported by an ever increasing body of literature, it is clear that health workers motivation has become a center of debate in Enterprises’ HRM Strategy and still be some current issues in today’s health care system. While a high incentive remuneration system motivated and encouraged the whole caregivers who became more productive and committed, poor or lack of incentive remuneration policy however not motivated and discouraged some caregivers professional who went from public sector to private sector or from developing countries to developed countries. To shed this problem this article examined the remuneration policy as a key determinant that motivated Togolese health employees. The objective of this article is to explore that incentive remuneration system tend to motivate caregivers. Based on the descriptive research methodology, data was collected and analyzed using SPSS. Findings suggest that a veritable remuneration policy is seen as a key determinant factor motivating Togolese healthcare employees. Money is important as a motivator and the motivating minimum-wage help employees to be more performance. and conclusions and recommendations were taken.