jimnoneill/paper-to-field-training huggingface dataset:
Fitness to fly: assessing cardiac disease among Air Force pilots

Field: Medicine (Health Sciences)

Abstract Introduction Aviation is a risk activity, particularly in pilots with cardiovascular (CV) disease. The occurrence of acute clinical events during flight may have catastrophic implications, justifying the relevance of cardiologic evaluation in Aviation Medicine. However, the evidence about the impact of CV diseases in this population is scarce. Aim To study the cardiac causes of incapacitation among pilot candidates and pilots of the Portuguese Air Force (PoAF) over a period of 20 years. Methods and results A retrospective analysis of cardiac causes of incapacitation between January 1999 and December 2018 was performed, both in PoAF candidates and pilots. In this period, the overall number of candidates was 2529 and the number of PoAF pilots was 760. Among the candidates, 41% (N=1086) were considered unfit, of which 4% (N=39) due to cardiac causes (all men aged 17-25), namely valvular diseases (N=27) and conduction/heart rhythm disturbances (N=12). Among the pilots, 2% (N=18) were considered unfit, mainly due to cardiac disease (50%; N=9). These pilots considered unfit pilots due to cardiac disease were men with mean age of 47±9 (30-60) years old, all unfit due to acute myocardial infarction, none occurring during flight. Conclusion Cardiac diseases were an uncommon cause of incapacitation among the pilot aviator candidates, but it was the main cause among the pilots of the PoAF during two decades, all due to acute myocardial infarction. Cardiac evaluation in Aviation Medicine is essential, focusing on CV risk stratification and preclinical detection of coronary artery disease.Figure 1
Three millimeter needlescopic splenectomy using three-port technique: report of three cases

Field: Medicine (Health Sciences)

Abstract We report our experience with needlescopic splenectomy (NS) for the surgical treatment of idiopathic thrombocytopenic purpura using a 3-mm needlescope with three ports. One patient was male and two were females, and their mean age was 58 years. The patient was placed in the right lateral decubitus position. The first 12-mm port was introduced through the lateral margin of the left rectus abdominis muscle, and the other two 3-mm ports were inserted in the left upper quadrant. NS was performed by a standard technique under the observation of 3.3-mm needlescope. The surgical procedure was successfully completed in all the patients. The mean duration of surgery, intra-operative bleeding volume and post-operative hospital stay were 176 min, 70 ml and 4.7 days, respectively. There were no particular peri-operative complications in spite of dense adhesions or simultaneous laparoscopic procedures. Our method is safe and feasible with low morbidity and without impairing cosmetic benefits.
App usability for measuring the heartbeat (Preprint)

Field: Health Professions (Health Sciences)

BACKGROUND

Apps for mobile phones can measure heart rate simply and painlessly.

OBJECTIVE

The objective of this research was to demonstrate that the Heart Rate Plus App is an easy, understandable, and attractive application for use by the general population and by nurses as well.

METHODS

The pilot case-control study study included 80 adult healthy volunteers, 40 nurses and 40 non-nurses. They then completed a questionnaire regarding the usability criteria of the App.

RESULTS

The entire study sample rated the App highly for Learnability (85%), Memorability (92.5%), and Understandability (87.5%) and Attractiveness (87.5%). The association of the variable Sex with usability criteria, a significant association was found between the Sex and Learnability (p = 0.044) and also between Sex and Understandability (p = 0.05).

CONCLUSIONS

Our fingings demonstrate that Heart Rate Plus App is an easy, memorable, understandable, and attractive application to use for the general population and for nurses.

CLINICALTRIAL

It is not a Trial.
Az eleséstől való félelem otthon élő idősek körében

Field: Health Professions (Health Sciences)

Abstract: Introduction: Due to fear of falling, older people may restrict their activities, causing muscle weakness and impaired balance and, consequently, admission to an institute. Accordingly, fear of falling is a common and serious health problem among older individuals. The prevalence of the fear of falling and its associated factors as well as possible preventive and therapeutic methods have been widely investigated in geriatrics. Aim: The aim of our study was to describe the prevalence of the fear of falling and its associations with demographic (age, gender) and health factors (age-related chronic diseases, functional mobility, falling in the previous year, medications) among community-living older adults. Method: Two-hundred individuals participated in the study. The fear of falling was diagnosed based on the cut-off value of the short Falls Efficacy Scale – International (FES-I). Logistic regression analysis was used to assess associations. In total, 61 participants were diagnosed with fear of falling. Results: In our sample, the fear of falling was associated with age, the number of diseases and functional mobility. Conclusion: The short FES-I is simple, easy to fill-out and has a validated Hungarian version as well. By its use, people of higher age affected by multiple chronic illnesses are primarily worth of screening in order to identify those who are in need for further more detailed examinations and, if needed, more targeted interventions. Orv Hetil. 2019; 160(5): 191–197.
Attitudes of public bus drivers towards technology integration in the dashboard design

Field: Engineering (Physical Sciences)

Integration of technological features, such as navigation and information displays, automation of manual controls and digitalization of displays, into the public bus can be promising in terms of providing solutions for the critical contextual problems of bus drivers, such as undesired interactions with passengers and increased cognitive workload caused by the necessity of checking time frequently for complying with the schedule. However, if these systems are not accepted by bus drivers, the solutions they provide become useless and they may even constitute critical threats for safety. Therefore, in this paper the aim is to investigate bus drivers' views towards technology integration in the bus, to provide technological functions, which correspond better to their needs. To achieve this aim, (1) drivers' attitudes towards general technology, (2) their attitudes towards current technology integration in the bus dashboard, and (3) degree of involvement with the current technological products were questioned with a structured questionnaire that was delivered to 30 respondents in interview format. The paper outlines the findings of the study by describing bus drivers' attitudes towards technology, identifying design features that lead to perception of technology in the dashboard, and making associations between the drivers' characteristics and their attitudes towards technology integration.
Analysis of variators in the brca1 and brca2 genes by ngs in patients from central brazil with suspected hboc syndrome: a new pathogenic variant identified

Field: Medicine (Health Sciences)

About 10‒15% of breast cancer cases are due to deleterious germ changes, more than half of which are located in the BRCA1 or BRCA2 genes. The screening of variants in these genes for patients at risk brings benefits for better clinical management of the patient as well as for the prevention of disease recurrences both in the proband and in their relatives. The profile of genetic variants is little known to the Brazilian population and, to date, there are no published data for the population of the central region of the country. This study aimed to analyze the profile of pathogenic variants (VP) and of uncertain significance (VUS) in the BRCA1 and BRCA2 genes in this population. We selected 102 patients seen at Hospital das Clínicas, Universidade Federal de Goiás, with clinical diagnosis of invasive ductal carcinoma that met the criteria of the National Comprehensive Cancer Networking 2016/2 for hereditary breast and ovarian cancer syndrome. A collection of 4mL of peripheral blood was carried out and submitted to subsequent extraction of genomic DNA, carried out using the PureLink kit (Invitrogen). The genes in question had all their exon-intron regions sequenced using the MiSeq device (Illumina) and the raw data were evaluated using the Sophia DDM software. The risk of in silico pathogenicity of the VUS was analyzed by the software POLYPHEN2, MutationTaster, SIFT, ESP5400, G1000, GnomAD. Of the total of 102 patients evaluated in this study, 22 (21.56%) had PV or VUS in the BRCA1 or BRCA2 genes. Of these, 16 patients (72.81%) had pathogenic variants, eight with PV in BRCA1 (c.5266dupC (2), c.3331_3334delCAAC, c.211A>G, c.3228_3229delAG, c.3700_3704delGTAAA, c.4484G>T and c.5305_5306ins20) and eight with PV in BRCA2 (c.156_157insAlu, c.4829_4830delTG, c.8488-1G>A, c.6405_6409delCTTAA (3), c.517-1G>A, c.2808_2811delACAA). A total of 7 patients (31.8%) presented VUS in these genes, one in the BRCA1 gene (c.179A>G) and five in the BRCA2 gene (c.280C>T, c.811G>A, 1096T>G, 1441A>G and c.5270A>G) of which only the variant c.1441A>G had low pathogenic potential in silico. A new PV still not described in the literature was also identified, variant c.5305_5306ins20 in the BRCA1 gene. These data suggest that all patients at risk in this population should be evaluated for PV or VUS in the BRCA1 and BRCA2 genes since the presence of these variants can help in the patient's prognosis and disease prevention.
Assessment of secondary metabolites and bioefficacies ofPeltophorum pterocarpum(DC.) Baker ex K. Heyne cell cultures

Field: Agricultural and Biological Sciences (Life Sciences)

Peltophorum pterocarpum (DC.) Baker ex. K. Heyne, is reputed for its medicinal importance. Its bark is used for dysentery, tooth powder, eye lotion, embrocating for pains and sores and bark also gives a dye of yellow color. In the present study, cell cultures of leaf explants were established on MS medium supplemented with benzene-6-aminopurine (BAP; 2 mg/L) and naphthalene acetic acid (NAA; 0.5 mg/L). Callus was harvested at the transfer age of 2, 4, 6, 8 and 10 weeks, dried, extracted in ethanol. Total levels of phenolics and flavonoids as also antimicrobial (agar well diffusion method) and antioxidant (DPPH and FRAP method) efficacies were evaluated. On phytochemical investigation, β-sitosterol and bergenin were isolated and identified. Higher levels of total phenolics and flavonoids were recorded in 8 weeks-old callus extract (12.40 ± 1.44 mg GAE/gdw and 22.5 ± 0.08 mg QE/gdw). In DPPH method 4, 6 and 8 weeks-old calli exhibited similar activity with IC50 value of 0.06 mg/mL. Likewise, 8 weeks-old callus exhibited higher FRAP activity (98.33 ± 10.40 mg AAE/g dw). On antibacterial screening, 10 weeks-old callus demonstrated appreciable results with inhibition zones of 24.33 ± 0.57, 21.00 ± 1.00, 11.00 ± 1.00 and 10.00 ± 0.00 mm against K. pneumoniae, B. subtilis, S. aureus and E. coli respectively.
Radiocarbon Dating. An Archaeological Perspective. By R. E. Taylor. 23 × 15 cm. Pp. xii + 212, 52 figs., tables. London: Academic Press, 1987. ISBN 0-12-684860-2. $39·50.

Field: Earth and Planetary Sciences (Physical Sciences)

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Quality of Working Life of Remote Employees: Methodological Approaches and First Assessments for the EU and Russia

Field: Social Sciences (Social Sciences)

The article reviews the theoretical and methodological provisions in the field of the quality of working life, summarizes the experience of foreign and Russian research in this area. Analyzed modern initiatives, approaches and proposals of international organizations. A system of indicators (characteristics) is proposed to describe the components of quality of working life of remote workers, it is concluded that these largely depend on personal circumstances (family situation, the presence of children, the ability to work at home and equipment of the workplace), which means that the characteristics of quality of working life can be supplemented with personal indicators that affect to the general level of quality of working life. Based on survey data in Europe and Russia, the risks of a decrease in the quality of working life of remote employees are shown, due to the blurring of the boundaries between work and personal life. Measures are proposed to organize the work of remote teams (primarily at the company level and in the development of the new legislation on remote work adopted in Russia) aimed at increasing the quality of working life of remote employees and reducing costs and profit growth for the employer. The problem areas are identified that require further research in terms of the development of the concept of the quality of working life.
Effect of harvest period on the quality of storage roots and protein content of the leaves in five cassava cultivars (Manihot esculenta, Crantz)

Field: Agricultural and Biological Sciences (Life Sciences)

The effect of harvest period on the quality of storage roots and leaves of cassava cultivars was determined in an experiment carried out in a randomized complete block design with four replications in a split plot scheme, with five cultivars in the plots and ten harvest times in the subplots. The IAC 13 cultivar had the highest rate of dry matter accumulation in the storage roots and the Mico cultivar the lowest. The period of least dry matter content in the storage roots occurred later for the Fécula Branca, Mico and IAC 14 cultivars, and the minimum starch content in the storage roots occurred later for the Fécula Branca and Mico cultivars. In general, the IAC 13, IAC 14 and Fécula Branca cultivars had higher dry matter content in the storage roots, while higher starch content in the dry and fresh matter were obtained in the Fécula Branca cultivar. The crude protein content in the leaves decreased as the plant aged.
Improved Bleach Plant Control Using Internal Model Control with Smith Predictor

Field: Chemical Engineering (Physical Sciences)

This paper presents the improved control of a benchmark pulping process. Open-loop tests were conducted to obtain a multiple-input multiple-output process model in the form of transfer function matrix. Using this model, the best set of input-output pairings was selected by using relative gain array (RGA) and relative disturbance gain techniques, both in static and dynamic modes. These analyses confirmed the setting provided by the authors of the Benchmark, based on static RGA analysis. Controller settings for each control loop were calculated using different internal model control (IMC) tuning methodologies and the best set of controller parameters was chosen by evaluating the control system performance for set-point tracking and disturbance rejection in terms of the integral of absolute error, settling time, time constant and percentage of overshoot. PI controllers combined with Smith-predictors, and tuned with IMC, providing the set-points of the Kappa factor controllers related to the quality variables of the process and Pi-only controllers tuned using IMC controlling the secondary variables give the best control performance. Smith predictors allow the controller designer to provide to the process controllers larger controller gains and smaller reset times, making the controlled response faster. Their ability to provide estimations of the process measurements when the real measurements are not available was especially useful in this process due to its large time delays.
DEPOSITIONAI, FRAMEWORK OF THE MESAVERDE FORMATION, WIND RIVER BASIN, WYOMING

Field: Earth and Planetary Sciences (Physical Sciences)

ABSTRACT The Mesaverde Formation defines a Late Cretaceous shallow- to non-marine clastic wedge (up to 600 meters (1968 feet) thick) developed in the Wind River Basin, Wyoming. The formation has been, and is currently, an exploration target for gas, but defining successful exploration strategies is hampered by the Mesaverde~ notoriously complex facies mosaic. We have integrated a data set utilizing detailed field mapping, facies descriptions, petrographic analysis, wire-line log correlations, and subsurface architectures interpreted for a small number of seismic lines, to construct a basinwide depositional framework for the Mesaverde strata. The resulting sequence stratigraphic interpretation permits us to recognize four major subdivisions that can be traced from the non-marine into shallow marine settings; these units are distinct from, and their inferred timelines cut across, the traditionally defined lithostratigraphic units of the Mesaverde and related units. For example, the Cody- Mesaverde formational boundary can be shown to be time-transgressive such that the oldest non-marine Mesaverde lithologies are genetically related to laterally equivalent shallow marine sandstone and mudstone typically attributed to the Cody. A preliminary palynological data set for the Mesaverde is presented that supports this depositional framework. Within the non-marine subdivisions of the Mesaverde Formation, detailed lateral mapping and measurement of channel sandstone and associated facies reveal that a two-fold architectural arrangement of stratal geometries can be recognized. The first consists of amalgamated channels (high density stacking) that form tabular sandstone bodies up to 50 meters (164 feet) in thickness (e.g., as developed in the lowermost Mesaverde unit and Teapot Member in the Maverick Springs area). The second is characterized by vertically and laterally isolated channel sandstone (low density stacking) encased in interfluve lithologies (e.g., middle Mesaverde unit in the Maverick Springs area). Our work has further corroborated that the basal unconformity of the Teapot Member defines a major surface of erosion, which cuts down section towards the west and south. Palaeocurrent data imply a reorganization of depositional slopes from the southeast- dominated sediment transport directions of the middle Mesaverde to the easterly-dominated directions of the Teapot. Recently published U-Th-He data from the Wind River Range indicate that cooling and uplift occurred -75Ma, consistent with the timing for the Teapot unconformity and basin reorganization proposed above. The diversity of facies within the Mesaverde Formation, and the difficulty arising from lateral and vertical facies changes and non-marine to marine correlation in the subsurface, has complicated reservoir exploration. Our results offer a paleogeographic and depositional model that can be used to refine and direct subsurface exploration strategies.
Taxonomy and Distribution of Benthic Foraminiferans in the Selected Group Islands of Gulf of Mannar Marine Biosphere Reserve

Field: Agricultural and Biological Sciences (Life Sciences)

The present work deals with the taxonomy and distribution of benthic foraminifera from Gulf of Mannar Marine Biosphere Reserve (GoMBR), South east Coast of India during 2020 – 2023. Sediment samples were collected from Mandapam, Keezhakarai and Vembar group of Islands through standard methodology, A total of 36 species belonging to 20 genera, 16 families and 4 orders. A holistic approach regarding soil texture and physico-chemical properties of soil and water shed more light on the diversity and distribution of foraminifera in GoMBR.
Synthesis of MOF, MDA, PIM, MVC, and BCE Notations and Patterns

Field: Computer Science (Physical Sciences)

Publications, including academic handbooks, contain numerous inconsistencies in the descriptions of applications of architectural methods and patterns hidden under the abbreviations such as MOF, MDA, PIM, MVC, BCE. An efficient analysis and the following software design, particularly when we are speaking of projects realized in large teams, requires standardization of the production process and the applied patterns and frameworks. This study attempted to sort out the system of notations describing this process and used to describe architectural patterns. Analysis of key notations—MOF and MDA, patterns MVC and BCE—was carried out, and a consistent system combining them into a whole was created.
Development of a coupled supersonic inlet-fan Navier–Stokes simulation method

Field: Engineering (Physical Sciences)

A coupled supersonic inlet-fan Navier–Stokes simulation method was developed by using COMSOL-CFD code. The flow turning, pressure rise and loss effects across blade rows of the fan and the inlet-fan interactions were taken into account as source terms of the governing equations without a blade geometry by a body force model. In this model, viscous effects in blade passages can also be calculated directly, which include the exchange of momentum between fluids and detailed viscous flow close to walls. NASA Rotor 37 compressor test rig was used to validate the ability of the body force model to estimate the real performance of blade rows. Calculated pressure ratio characteristics and the distribution of the total pressure, total temperature, and swirl angle in the span direction agreed well with experimental and numerical data. It is shown that the body force model is a promising approach for predicting the flow field of the turbomachinery. Then, coupled axisymmetric mixed compression supersonic inlet-fan simulations were conducted at Mach number 2.8 operating conditions. The analysis includes coupled steady-state performance, and effects of the fan on the inlet. The results indicate that the coupled simulation method is capable of simulating behavior of the supersonic inlet-fan system.
Continuous culture condition of yeast on corn steep water and its process control. Part 4. Studies on value-added utilization of corn steep liquor, a byproduct of corn starch plant.

Field: Chemical Engineering (Physical Sciences)

酵母(Saccharomyces cerevisiae var.ellipsoideus IAM4125)の培養によるCSW中の乳酸の資化を目標に,CSW培地(乳酸1.8%)による酵母の単槽連続培養(液量151,回転数300rpm,通気量151/min,温度30。C,pH4.0～4.5)を検討して,次の結果を得た. (1)酵母の増殖はMonod型増殖速度式に従い,μmax=0.20hr-1,Ks=0.139/1,菌体収率=0.29となった. (2)菌体に関する生産性はXmDm=0.889/l・hrとなり,回分培養の場合の約3倍になることを認めた.また,その残存乳酸濃度は1.139/1になることが認められた. (3)無殺菌のCSW培地による酵母の開放系連続培養は培地pH3.5～4.5で可能であることが認められた.
Renaissance der Oberflächenkultur: Produktion von Mutterkornalkaloiden und Sporenbildung

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Industrially acceptable production of ergot alkaloids in surface culture under sterile conditions is described. After elucidation of the biochemical and morphological differentiation in the production microorganisms it is possible to elaborate a relatively simple cultivation method with good yields. Surface cultivation is especially advantageous for the production of spores in large quantities which are used as inoculum in industrial fermentations or as infection material (field production of ergot alkaloids, mycoinsecticides).