jimnoneill/paper-to-field-training huggingface dataset:
Fertility Trends and Adverse Pregnancy Outcomes in Female Patients With Psoriasis in the UK

Field: Medicine (Health Sciences)

Importance Evidence regarding fertility trends and obstetric outcomes among patients with psoriasis is limited by studies of small sample sizes, noninclusion of comparators, and the lack of accurate pregnancy records. Objective To investigate fertility rates and obstetric outcomes of pregnancies in female patients with psoriasis compared with age- and general practice–matched comparators without psoriasis. Design, Setting, and Participants This population-based cohort study used data from 887 primary care practices that contributed to the UK Clinical Practice Research Datalink GOLD database between 1998 and 2019, linked to a pregnancy register and Hospital Episode Statistics. There were 6 223 298 patients of common childbearing ages (15-44 years), and 63 681 patients with psoriasis had at least 1 year of follow-up data prior to the diagnosis of psoriasis. For each patient with psoriasis, 5 patients were matched by age from the same general practice. The median follow-up duration was 4.1 years. Data analysis was performed in 2021. Exposures Patients with psoriasis were identified using clinical diagnostic codes from consultations. Main Outcomes and Measures Fertility rates were calculated as the number of pregnancies per 100 patient-years. The outcomes of each pregnancy recorded in the pregnancy register or Hospital Episode Statistics were screened to identify obstetric outcomes. A negative binomial model was used to examine the association between psoriasis and the fertility rate. Logistic regression was applied to compare the association between psoriasis and obstetric outcomes. Results A total of 63 681 patients with psoriasis and 318 405 matched comparators were included in the analysis (median [IQR] age, 30 [22-37] years). Lower fertility rates (rate ratio, 0.75; 95% CI, 0.69-0.83) were found in patients with moderate to severe psoriasis. Compared with matched comparators without psoriasis, pregnancies in patients with psoriasis had a higher risk of loss (odds ratio, 1.06; 95% CI, 1.03-1.10); however, there was no increase in the risks of antenatal hemorrhage, preeclampsia, or gestational diabetes. Conclusion and Relevance In this cohort study, patients with moderate to severe psoriasis had a lower fertility rate, and the risk of pregnancy loss was higher than in matched comparators without psoriasis. Future research should identify the mechanism of increased risk of pregnancy loss among patients with psoriasis.
Appropriating Gaming - A Quantitative Content Analysis and Issue Mapping of the Online Campaign #NotMyBattlefield

Field: Social Sciences (Social Sciences)

This thesis aims to examine how online engagement in the #NotMyBattlefield campaign can be understood as an online harassment campaign and a continuation of the Gamergate controversy. Research has shown that Gamergate was appropriated by external political groups, such as the Alt-Right. The Alt-Right is known to be highly adept in media manipulation, executing deliberate framing strategies as a means to push political agendas and gain influence online (Blodgett, 2020, p. 187; O’Donnell, 2019, p. 10). The group's appropriation of Gamergate and gaming culture is highly indicative of the politicisation of gaming culture. \nThe aim of this research is twofold. First, an overarching content analysis seeks to analyse the rhetoric arguments and thematic patterns found in conjunction with the hashtag #NotMyBattlefield on Twitter. Secondly, this thesis employs an adapted version of Burgess and Matamoros-Fernández (2016) method of issue mapping. The purpose of this mapping is to analyse the campaign’s relationship to prominent actors within online media, as well as to examine the structure and patterns the campaign followed. The combined results of the content analysis and issue mapping reveal how the #NotMyBattlefield can be understood as a continuation of Gamergate, influenced by Alt-Right ideologies. They bare similarities in the way feminism and political correctness are painted out to be instigators of an attack on gaming culture. \nFurthermore, the results also reveal how such campaigns are primarily reactionary - only showing increased levels of activity in response to external factors and events. At no point in time did the campaign show any indications of self-sustained motivation or engagement. The results of this thesis further signify the politicisation of gaming culture. The influence of external forces, such as the Alt-Right, signifies a need for further research in order to gain a better understanding of how to circumvent and prevent the radicalisation of gaming.
Myocardial Laceration Not Demonstrated by Continuous Electrocardiographic Monitoring Occurring during Pericardiocentesis

Field: Medicine (Health Sciences)

IN 1951 Bishop et al. described the technic of percutaneous pericardiocentesis with continuous electrocardiographic monitoring in which the paracentesis needle serves as an exploring electrode.1 With this procedure, an injury current is detected if the needle contacts the ventricular (ST-segment elevation) or a trial (PR-segment elevation) epicardium. Numerous studies have shown the technic to be of value in preventing inadvertent myocardial puncture and to clarify the site of origin of bloody fluid.1 2 3 4 In the reported exceptions, myocardial penetration and laceration was accompanied by electrocardiographic changes when this technic was used.5 6 7 8 We recently encountered a circumstance in which a definite myocardial laceration occurred without . . .
The challenge of professionalism and institutional self-understanding: a short communication

Field: Social Sciences (Social Sciences)

Museum educators are often key staff at museums in the sense that they are the ones the public, school groups and other visitors often meet. However, a study of the Nordic and Baltic countries shows that many museum educators lack formal education within the fields of pedagogical theory or learning. Their role as professional educators can therefore be questioned - in particular by other educators, such as teachers. This article discusses what the implications are of this lack of formal education, for museums as institutions as well as for the museum educators.
On bitopological -semi-generalised continuous maps.

Field: Mathematics (Physical Sciences)

Abstract. We introduce a new type of generalized sets called (1, 2) ∗ semi-generalized closed sets and a new class of generalized functions called (1, 2)∗ semi-generalized continuous maps. We obtain several characterizations of this class and study its bitopological properties and investigate the relationships with other new functions like (1, 2) ∗ g-continuous maps and (1, 2) ∗ gc-irresolute maps.
REFINE: a database of linked clinical data and genomic biomarkers in renal cell carcinoma patients receiving immunotherapy-based treatment regimens

Field: Medicine (Health Sciences)

Abstract The REnal cancer consortium for Focused Investigation of Novel biomarkers and Expression (REFINE) consortium represents an important initiative in integrating clinical data with molecular sequencing in patients with advanced renal cell carcinoma (RCC) treated with immunotherapy-based approaches. By leveraging real-world evidence and genomic analysis, this consortium aims to explore putative predictive biomarkers with the potential to inform personalized treatment strategies. Findings from the REFINE database may further contribute to our understanding of disease courses of immunotherapy-based approaches for various molecular subtypes of RCC, associations of race and ethnicity with RCC treatment and outcomes with representation of patient populations underrepresented in clinical trials, and optimizing treatment sequencing.
Aspergillus fumigatus—a systematic review to inform the World Health Organization priority list of fungal pathogens

Field: Medicine (Health Sciences)

Abstract Recognizing the growing global burden of fungal infections, the World Health Organization established a process to develop a priority list of fungal pathogens (FPPL). In this systematic review, we aimed to evaluate the epidemiology and impact of invasive infections caused by Aspergillus fumigatus to inform the first FPPL. The pre-specified criteria of mortality, inpatient care, complications and sequelae, antifungal susceptibility, risk factors, preventability, annual incidence, global distribution, and emergence were used to search for relevant articles between 1 January 2016 and 10 June 2021. Overall, 49 studies were eligible for inclusion. Azole antifungal susceptibility varied according to geographical regions. Voriconazole susceptibility rates of 22.2% were reported from the Netherlands, whereas in Brazil, Korea, India, China, and the UK, voriconazole susceptibility rates were 76%, 94.7%, 96.9%, 98.6%, and 99.7%, respectively. Cross-resistance was common with 85%, 92.8%, and 100% of voriconazole-resistant A. fumigatus isolates also resistant to itraconazole, posaconazole, and isavuconazole, respectively. The incidence of invasive aspergillosis (IA) in patients with acute leukemia was estimated at 5.84/100 patients. Six-week mortality rates in IA cases ranged from 31% to 36%. Azole resistance and hematological malignancy were poor prognostic factors. Twelve-week mortality rates were significantly higher in voriconazole-resistant than in voriconazole-susceptible IA cases (12/22 [54.5%] vs. 27/88 [30.7%]; P = .035), and hematology patients with IA had significantly higher mortality rates compared with solid-malignancy cases who had IA (65/217 [30%] vs. 14/78 [18%]; P = .04). Carefully designed surveillance studies linking laboratory and clinical data are required to better inform future FPPL.
Determination of a single nucleotide polymorphism (SNP) of the TNFalpha-R1 region (TNFRSF1A) in patients with lung sarcoidosis: Preliminary results

Field: Medicine (Health Sciences)

Background: Sarcoidosis is a multisystem disease characterized by noncaseating granuloma formation, mostly affecting the lung. A variant in the TNFRSF1A region has been found to codify a protein capable of TNF antagonism. This variant is also associated with the development of multiple sclerosis but is absent in autoimmune diseases highly responsive to TNF-alpha treatment. Aim: To search for the presence of TNFRSF1A SNP in sarcoidosis patients and its potential correlation with disease phenotype. Patients and method: 79 patients with histologically proven lung sarcoidosis (49 male, 30 female) and 50 healthy controls (HC) were studied. Radiological stage and organ involvement were assessed. DNA was extracted from peripheral blood and rs1800693 SNP was determined by PCR. Genotyping was performed by pyrosequencing. Correlation with stage and clinical profile of sarcoidosis was investigated. Results: The alleles of rs1800693 SNP were in Hardy-Weinberg equilibrium in the studied subjects. The frequency of A/A genotype was 27%, A/G 54% and G/G 19% in sarcoidosis patients, similar to HC. The mean duration of disease was 4.9±3 years. No correlations were seen between genotype and age at onset, gender, serum ACE, organ involvement or use of corticosteroids. In patients with the G/G genotype, DLCO at diagnosis was significantly lower than in those with the A/G or A/A genotype (59±19 vs 73±11 and 79±11% pred, p=0.019) and duration of disease tended to be longer (6.1 vs 5.2 and 4.3 years, respectively). Conclusion: The presence of the G allele of the rs1800693 SNP in sarcoidosis can be related to more severe lung functional impairment in sarcoidosis.
Scavenger functions of the liver endothelial cell

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Research Article| March 01 1990 Scavenger functions of the liver endothelial cell B Smedsrød; B Smedsrød *Institute of Medical Biology, University of Tromsø, Box 977, N-9001, Tromsø, Norway Search for other works by this author on: This Site PubMed Google Scholar H Pertoft; H Pertoft †Department of Medical and Physiological Chemistry, University of Uppsala, Uppsala, Sweden Search for other works by this author on: This Site PubMed Google Scholar S Gustafson; S Gustafson †Department of Medical and Physiological Chemistry, University of Uppsala, Uppsala, Sweden Search for other works by this author on: This Site PubMed Google Scholar T C Laurent T C Laurent †Department of Medical and Physiological Chemistry, University of Uppsala, Uppsala, Sweden Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1990) 266 (2): 313–327. https://doi.org/10.1042/bj2660313 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation B Smedsrød, H Pertoft, S Gustafson, T C Laurent; Scavenger functions of the liver endothelial cell. Biochem J 1 March 1990; 266 (2): 313–327. doi: https://doi.org/10.1042/bj2660313 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1990 London: The Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Dynamic Hip Screw Treatment for Intertrochanteric Fractures in the Elderly: A Summary of Results

Field: Medicine (Health Sciences)

Objective: The objective was to find out how well the Dynamic Hip Screw (DHS) worked after treating intertrochanteric fractures in older patients. Study Design: A descriptive study Place of study & Duration: Ayub Teaching Hospital Abbottabad and Abbottabad International Medical institute Abbottabad. May 2022 to April 2023 Methods: Total 190 patients of both genders were presented in this study. All senior patients who matched the inclusion criteria and had stable intertrochanteric fractures (Evans type IA and Type IB) were evaluated for functional outcome using the Harris Hip Score (HHS). Depending on the HHS score, the results were categorized as exceptional (90 to 100), good (80 to 90), fair (70 to 80), or bad (<70) at 6 months. Results: We found excellent outcomes in 100 (52.6%) cases, good in 57 (30%) cases, 24 (12.2%) found fair and poor outcomes in 9(4.7%) cases. Conclusion: The majority of our elderly patients who underwent Dynamic Hip Screw (DHS) treatment for stable intertrochanteric fractures had excellent and good functional outcomes. When treating stable intertrochanteric fractures in older patients, DHS is the implant of choice. Keywords: Dynamic Hip Screw (DHS), Outcomes, Elder patients.
Ḥorbat Bizqa (Northwest)

Field: Arts and Humanities (Social Sciences)

In May 2014, a salvage excavation was conducted at the 'Enav Center in Modi'in (Permit No. A-7136; map ref. 196482-547/643405-73), prior to construction. The excavation, undertaken on behalf of the Israel Antiquities Authority and financed by Ofir Gamliel G. and Destiny, Ltd., was directed by J. Marcus, with the assistance of Y. Amrani (administration), I. Kornfeld (preliminary inspections), A. Dagot (GPS), and laborers from Shefar'am and Kafr Manda.
Physiological characteristic changes during the process of seed germination and seedling growth of Kostelezkya virginica under the NaCl stress

Field: Agricultural and Biological Sciences (Life Sciences)

Using 1/4 Hoagland as the basic culture solution,the status of seed germination and seedling growth of Kostelezkya virginica(L.) Presl.under 0.5%-2.5% NaCl stress was researched.With the increasing of NaCl concentration,the seed germination rate decreased gradually.The seeds treated by 2.5% NaCl did not germinated,but seeds still germinated and got similar germination rate as CK when NaCl stress was canceled.The seedlings growing in 0.5%-1.0%NaCl culture solution were much better than that in higher salt concentration,and had higher chlorophyll content and root system activity than CK,but got bad and chlorophyll content was reduced when seedlings cultured in 1.5%-2.0% NaCl solution.The MDA content of seedling was decreased under NaCl stress.In addition,the adaptation mechanism of K.virginica to NaCl stress was discussed.
Appearance Based Robust Face Detection using Adaboost 1 Dr. P.K.Suri,

Field: Computer Science (Physical Sciences)

The problem of face detection is quite challenging. Many techniques have been used for detection of faces from the given set of images. In this paper, we present Adaboost based SNoW classifier for face detection. The accuracy of the system is high as compared to that of other systems. We used cascading to get strong classifiers from weak classifiers. We further proposed asymmetric boosting for fast detection of faces.
[Studies on synergistic effect of sulbenicillin and dibekacin against gram-negative bacilli (author's transl)].

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

In vitro synergism of sulbenicillin and dibekacin was investigated with 19 strains of E. coli, 20 strains of Enterobacter and 20 strains of Pseudomonas aeruginosa on agar plates. As the results, sulbenicillin and dibekacin were found to be synergistically bacteriostatic against all these organisms, though the synergistic effects were somewhat less potent against E. coli. The concentrations of dibekacin required for assuming a clear synergism were 0.78 approximately 1.56 mug/ml.
Preliminary Screening of the Antibacterial and Synergistic Effects of Psidium guajava, Piper betle, and Senna alata Leaf Extracts Against Environmental Bacteria

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract This research explores the antibacterial and synergistic effects of Psidium guajava (guava), Piper betle (betel), and Senna alata (acapulco) leaf extracts against environmental bacteria collected from soil, yogurt, and unwashed surfaces. Using the agar disk diffusion method, the extracts were tested at varying concentrations (25%, 50%, 75%, and 100%) to evaluate bacterial inhibition. Guava extract exhibited moderate antibacterial activity, while the 75% combination of all three extracts demonstrated a potential synergistic effect, especially against Gram-negative bacteria. This study was conducted by senior high school STEM students at Marcelo H. Del Pilar National High School, located in Malolos, Bulacan, Philippines. It was originally presented during a student research colloquium and first published on OSF: https://osf.io/mzc7r/
Abstract 69: The Pan Asian Resuscitation Outcomes Study (PAROS): Characteristics of Patients with Out-of-Hospital Cardiac Arrest Across 7 Countries in Asia

Field: Medicine (Health Sciences)

Objectives: The Pan Asian Resuscitation Outcomes Study (PAROS) Clinical Research Network (CRN) includes Japan, Singapore, South Korea, Malaysia, Taiwan, Thailand, and UAE-Dubai. In this study, we aim to report the characteristics of out-of-hospital cardiac arrests (OHCA) patients and events in Asia. Methods: This is a prospective, international, multi-center cohort study of OHCA across the Asia-Pacific including data from January 2009 to December 2012. We used a standardised taxonomy and case record form to collect common variables. Data were provided via an online electronic data capture (EDC) system or exported data from national registries. Cases included all OHCA presenting to emergency medical services (EMS) and Emergency Departments. Primary outcome was survival to hospital discharge or survived to 30 days post cardiac arrest. Results: A total of 66,786 cases from January 2009 to December 2012 were included, of which 40,463 cases were presumed cardiac etiology and resuscitated by EMS. The mean age varied from 49.7 (UAE) to 71.7 (Japan). The proportion of males ranged from 57.9 (Japan) to 82.7 (UAE). Proportion of unwitnessed arrests ranged from 26.4% (Thailand) to 67.9% (Taiwan). Presenting rhythm ventricular fibrillation (VF) ranged from 4.1% (Malaysia) to 19.8% (UAE). Bystander cardiopulmonary resuscitation CPR) rates varied from 10.5% (UAE) to 42.4% (Korea), however Conclusion: Characteristics and outcomes of OHCA patients vary widely across Asia. This variation may be related to patient and system differences across countries.
Orphan Designation and Cisplatin/Hyaluronan Complex in an Intracavitary Film for Malignant Mesothelioma

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Pleural mesothelioma is a lung diffuse tumor, whose complete resection is unlikely. Consequently, metastases reappear where the primary tumor was removed. This paper illustrates the orphan medicine designation procedure of an intracavitary cisplatin film and related pharmaceutical development aspects requested by the European Medicines Agency (EMA) in its Scientific Advice. Since cisplatin pharmacokinetics from the implanted film in sheep resulted substantially modified compared to intravenous administration, the formation of a cisplatin/hyaluronan complex had been hypothesized. Here, the interaction between sodium hyaluronate (NaHA) and cisplatin (CisPt) was demonstrated. Size exclusion chromatography qualitatively evidenced the complex in the film-forming mixture, only showing the NaHA peak. Atomic absorption spectroscopy of the corresponding fraction revealed platinum, confirming the interaction. Reverse phase HPLC quantified about 5% free cisplatin in the film-forming mixture, indirectly meaning that 95% was complexed. Finally, a study of CisPt release from the film assessed how CisPt/NaHA complex affected drug availability. In water, a medium without chloride ions, there was no release and the film remained intact for 48 h and longer, whereas the placebo film dissolved in 15 min. In 0.9% NaCl medium, the film became more soluble, dissolving within 3–4 h. However, cisplatin release was still controlled by the existing complex in solution until chloride ions displaced it. While the film modified its dissolution with aging, CisPt release remained unaffected (90% released in 48 h).
Computing Semantic Relatedness from Human Navigational Paths: A Case Study on Wikipedia

Field: Computer Science (Physical Sciences)

In this article, the authors present a novel approach for computing semantic relatedness and conduct a large-scale study of it on Wikipedia. Unlike existing semantic analysis methods that utilize Wikipedia’s content or link structure, the authors propose to use human navigational paths on Wikipedia for this task. The authors obtain 1.8 million human navigational paths from a semi-controlled navigation experiment – a Wikipedia-based navigation game, in which users are required to find short paths between two articles in a given Wikipedia article network. The authors’ results are intriguing: They suggest that (i) semantic relatedness computed from human navigational paths may be more precise than semantic relatedness computed from Wikipedia’s plain link structure alone and (ii) that not all navigational paths are equally useful. Intelligent selection based on path characteristics can improve accuracy. The authors’ work makes an argument for expanding the existing arsenal of data sources for calculating semantic relatedness and to consider the utility of human navigational paths for this task.
The Beginnings of TECO

Field: Computer Science (Physical Sciences)

I came up with the name TECO in 1962 while sitting in Ye Hong Guey, my favorite restaurant in Boston's Chinatown during my undergraduate years at the Massachusetts Institute of Technology. I had been working on a little program to help me write other programs, a common activity in the day when a computer (the digital equipment corporation PDP-1) would be delivered with almost no software. My program had gotten to the point that it needed a name, so my friend Pete Peterson and I were kicking around possibilities and their acronyms. This paper present the beginning of TECO which means text editor and corrector and described its documentation.