jimnoneill/paper-to-field-training huggingface dataset:
TITLE Reconceptualizing School Leadership for the 21st Century: Music, Metaphors, and Leadership Density.

Field: Social Sciences (Social Sciences)

Efforts to change the role of principals over the past 30 years typically reflect a leader-centrist perspective of schools illustrated by the metaphors of a marching band or the slightly less hierarchical classical orchestra. In these conceptual systems, policy (score) is generated (composed) by policymaking bodies (composers) with principals (conductors) directing teachers (orchestra members) and students (mini-orchestras). Small-combo jazz differs from other musical groups in the degree of creativity encouraged, member rapport, form and structure, audience expectations, constant changes in leadership from player to player, with each member bringing unique knowledge and expertise, and the greater importance of each group member&apos;s contributions. Unlike traditional schools, jazz schools are process, not outcome, oriented, and assume teachers and students create their own knowledge in harmony with others. Like small-combo jazz, characteristics of schools with high leadership density include: (1) individual and
How Can We Best Diagnose Severity Levels of Dry Eye Disease: Current Perspectives [Corrigendum]

Field: Medicine (Health Sciences)

Chester T, Garg S, Johnston J, Ayers B, Gupta P. Clin Ophthalmol. 2023;17:1587&amp;#x2013;1604.\nPage 1587, author list, the text &amp;#x201C;Brandon Ayers&amp;#x201D; should read &amp;#x201C;Brandon Ayres&amp;#x201D;.\nThe authors have also advised the units of measurement for Lactoferrin in Figure 1 on page 1597 is incorrect. The correct Figure 1 is shown below.\n\nFigure 1 (A and B) Identification and management of aqueous-deficient dry eye. (C and D) Identification and management of evaporative dry eye.\n\nThe authors apologize for this error and advise it does not affect the results of the paper.
Management Education for Practicing Managers: Combining Academic Rigor With Personal Change and Organizational Action

Field: Business, Management and Accounting (Social Sciences)

For several decades, management educators have discussed the difficulty of accommodating the competing values of academic rigor and organizational relevance. Only a few articles, however, consider approaches for integrating theory and practice in educational programs for working managers. Building on 15 years of experience in executive education, this article presents an approach grounded in experiential and action learning, which combines personal learning and organizational action without compromising academic standards. The following educational practices are discussed and evaluated: reflection reports, personal learning contracts, roundtable examinations, live cases, action-oriented thesis work, and organizational knowledge theaters. Taken together, the approach constitutes a powerful program design to address multiple learning loci and combinations of reflection and action, albeit one with considerable challenges and difficulties, as the authors discuss.
Development and initial clinical experience with a paclitaxel-coated balloon for the treatment of benign difficult esophageal strictures

Field: Medicine (Health Sciences)

Background and Aims: Benign esophageal strictures can result in dysphagia and decreased quality of life.A novel drug coated dilation balloon (DCB) was developed to dilate strictures while concurrently delivering paclitaxel to reduce recurrence.Initial preclinical histological and pharmacokinetic (PK) data in addition to first-in-human pilot data are presented.Methods: 1) Thirty-nine healthy swine were treated by 3 different paclitaxel dosing regimens or a bare balloon.Paclitaxel PK elimination profile in plasma and tissue as well as local tissue responses were evaluated.2) Nine adult human subjects were treated and followed for up to 2 years with dysphagia scores, safety, and imaging.Results: 1) Histological and PK analysis demonstrated paclitaxel present in treated tissues through 28 days post-procedure, while plasma levels were minimal (1 ng/ml at 155 mg total drug dose).No local or systemic drug toxicity was found.2) 9 human subjects with an average initial stricture diameter of 6.4 mm and an average Ogilvie Dysphagia Score (ODS) of 2.2 were treated.No major treatment related complications occurred.Retreatment rate through 2 years was 11%.Five subjects completed 2-year follow-up, with an average 2-year ODS of 0. Stricture diameter improved to 19.4±0.9 mm at 1 year (n=5). Conclusion:1) Animal studies demonstrate that DCB treatment of esophageal mucosa appears safe with paclitaxel still present in tissue after 1 month but minimal plasma levels.2) Initial results in humans indicate DCB can be safely applied with clinical relevant increases in esophageal lumen at 1 year with symptomatic improvement.
Genetic Analysis of Yield and Its Components of B. napus Hybrids Using Resynthesized Rapeseed Lines

Field: Agricultural and Biological Sciences (Life Sciences)

穿过双父母 Brassica 获得的重新综合的油菜籽敲 and Brassica oleracea 在与 Brassica 马来麝栽培变种相比的因为他们的更高基因的基础的混合繁殖有重要潜力。在这研究， 8 ×用四 B 的 8 完全的 diallel 实验。马来麝栽培变种(BN ) 并且四重新综合油菜籽线(RS ) 作为父母被设计为收益部件学习杂种优势和基因继承。结果每植物为产量显示出那杂种优势，豆荚的数字每豆荚每种子的植物和数字高与工具 32.77， 24.49 和 15.71% ，分别地。Diallel 分析证明添加剂和主导的效果为产量是重要的并且产出部件。除了 1 000 种子重量，所有特点为 b1 平均数广场是重要的并且展出了方向性的优势。主导的基因每植物在产量上有积极效果，豆荚每植物和 1000 种子种子上的重量，和否定效果每豆荚(r =? 0.86， ? 0.62， ? 0.41，和 0.47，分别地) 。为产量的狭窄感觉的可遗传性每植物，豆荚分别地为四个特点每豆荚每植物，和 1 000 种子重量和种子是 66， 31， 46 和 78% 。F1 混血儿与 B 相比显示出可观的收益。马来麝栽培变种什么时候 B。马来麝栽培变种和重新综合的油菜籽被用作父母(NR 混血儿) ，与每植物的许多更多的豆荚和每与油菜籽栽培变种相比的豆荚的更低的种子，显示重新综合的油菜籽可能在当前的混合繁殖节目是适用的。
Abstract B12: The antitumor and antiangiogenic activity of brivanib, a dual inhibitor of VEGFR-2 and FGFR-1 kinases

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Angiogenesis plays a central supporting role in tumorigenesis in a wide variety of different cancer types. This complex and highly regulated process has been shown to be driven by various proangiogenic factors. The vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) family of growth factors in conjunction with their associated tyrosine kinase receptors exert a major influence on tumor growth and dissemination, and potentially work synergistically to promote angiogenesis. Brivanib alaninate (BMS-582664) which is currently in phase III clinical trails is the orally active prodrug of brivanib (BMS-540215), a selective dual inhibitor of VEGF and FGF signaling. We demonstrate here that in vivo brivanib provides antitumor activity in a broad range of xenograft models over multiple dose levels, and that brivanib alaninate demonstrates dose-dependent efficacy equivalent to brivanib. Brivanib alaninate also reduces tumor cell proliferation as determined by a significant reduction in Ki-67 staining as well as a decrease in tumor vascular density as reflected by a reduction in CD34 staining, a cellsurface marker of endothelial cells. Additionally, using Matrigel™ plug assays in athymic mice we demonstrated that brivanib alaninate inhibits angiogenesis driven by VEGF or bFGF alone as well as when both of these cytokines are combined to drive angiogenesis in this model. Moreover, brivanib was more effective in inhibiting angiogenesis in this model system under all these conditions when compared to either bevacizumab, an antibody directed at the human VEGF cytokine or DC101, an antibody directed at the murine form of VEGF receptor-2. Dynamic contrast-enhanced magnetic resonance imaging, used to assess the effects of brivanib alaninate on tumor microcirculation, demonstrated a marked decrease in contrast agent uptake at an efficacious dose level, with a reduction in area under the plasma concentration-time curve from time 0 to 60 min (AUC60) at 24 h and 48 h of 54% and 64%, respectively. These results demonstrate that brivanib alaninate is an effective antitumor agent in preclinical tumor and angiogenesis models across a range of doses, and that efficacy is accompanied by changes in cellular and vascular activities. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):B12.
Modelling the Binding of Cytotoxic Dinuclear Copper Complexes to two Neighboring Phosphate Esters of DNA Using Glutarate: A Tetranuclear Metallo‐Macrocycle vs a Dinuclear Model

Field: Chemistry (Physical Sciences)

Abstract A family of dinuclear complexes was rationally designed to bind to two neighboring phosphate diesters of DNA by molecular recognition. Although these complexes bind strongly and irreversibly to DNA and induce apoptosis in cancer cells, a direct proof of the intended binding mode is missing. To mimic two neighboring phosphate diesters of DNA, we use here the dicarboxylate glutarate as a difunctional ligand. Starting from the acetate‐bound Cu II 2 complex, protonation results in the de‐coordination of acetate and allows the synthesis of the glutarate‐bound complex. Instead of bridging two Cu II ions of one dinuclear complex, two glutarates bridge two dinuclear complexes resulting in a tetranuclear metallo‐macrocycle. The molecular structures of two different salts differ in the square‐pyramidal coordination to the Cu II ions. The carboxylate stretching modes, the d‐d and the CT transtitions are not sensitive enough to resolve these differences. The exchange coupling is weakly antiferromagnetic between the Cu II ions in the dinuclear subunits and negligible between the subunits via the glutarates. The consequences for suited ligands to model the binding to two neighboring phosphate diesters in the DNA backbone is discussed.
COVID-19 and Brazilian handball coaches: impacts on training prescription and professional learning

Field: Social Sciences (Social Sciences)

Abstract Aims: This study aimed to analyze the influences of social isolation on the professional performance of Brazilian handball coaches and their expectations for the return of training sessions. Methods: Fifty-two handball coaches participated in this study (Mage=37.4 years; SDage=8.4), who coach U-8 to adult teams, and answered an online survey divided into two main sections: a) coaches’ actions with athletes and/or teams throughout social isolation; b) professional learning during social isolation. Descriptive statistics were used for quantitative data analysis and Thematic Analysis for qualitative data analysis. Results: The coaches mentioned that the contact with the teams has been made mostly with WhatsApp (94.2%) and Google Meet or Zoom (75.0%), in which coaches mainly emphasize physical fitness (69.2%) and tactical knowledge (67.3%). For professional learning, coaches are participating in online lectures (96.2%), and virtual meetings (92.3%). Coaches also seek content mainly related to teaching approaches (82.7%), and specific handball exercises (75.0%). Regarding expectations after the social isolation, coaches reported concern about uncertainties for sports practice (restriction of physical contact, decreased incentives for teams, and competitions) and possible psychological benefits (motivation to practice, overcoming difficulties, and learning new resources). Conclusion: The coaches revealed the concern about maintaining the athletes’ performance during the social isolation, the uncertainties for the future of the teams, and the difficulties to use different resources for training. We suggested that the courses for coaches emphasize aspects that enable the learning of new technologies (e.g. social networks, video edition, and research platforms).
Propagation Measurement of a Pedestrian Tunnel at 24 GHz for 5G Communications

Field: Engineering (Physical Sciences)

In this paper, we report the results of a field measurement campaign carried out inside a pedestrian tunnel at 24 GHz in two conditions, namely, empty tunnel scenario and busy tunnel scenario with pedestrian movement. The experiment measures the fading effects of various groups of pedestrian crowds using directional antennas at the transmitter and receiver for millimeter-wave radio communications. Having presented and analyzed the measurement data in several diverse scenarios, we have further investigated human scattering effects in the crowded pedestrian tunnel and performed ray-tracing simulation for an empty pedestrian tunnel condition. Because tunnel is an enveloped scenario that is not bound by any geographic areas, the results of this study can be applied to a wider scenario like other pedestrian tunnels across the globe. Above all, these findings contribute towards ensuring wireless connectivity for everyone even in a remote scenario like underground passages.
Functional Mapping of the U3 Small Nucleolar RNA from the Yeast Saccharomyces cerevisiae

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The U3 small nucleolar RNA participates in early events of eukaryotic pre-rRNA cleavage and is essential for formation of 18S rRNA. Using an in vivo system, we have developed a functional map of the U3 small nucleolar RNA from Saccharomyces cerevisiae. The test strain features a galactose-dependent U3 gene in the chromosome and a plasmid-encoded allele with a unique hybridization tag. Effects of mutations on U3 production were analyzed by evaluating RNA levels in cells grown on galactose medium, and effects on U3 function were assessed by growing cells on glucose medium. The major findings are as follows: (i) boxes C' and D and flanking helices are critical for U3 accumulation; (ii) boxes B and C are not essential for U3 production but are important for function, most likely due to binding of a trans-acting factor(s); (iii) the 5' portion of U3 is required for function but not stability; and, (iv) strikingly, the nonconserved hairpins 2, 3, and 4, which account for 50% of the molecule, are not required for accumulation or function.
Other histories

Field: Arts and Humanities (Social Sciences)

Abstract This is an interesting and important book. In one sense, its' authors deal with familiar lines of enquiry surrounding the cultural contexts of the production and consumption of photography. However, the importance of this book is in the choice of sites where these discussions are played out. Rather than focusing entirely on the Western colonial context and the proscribed nature of the ideological approaches of Edward Said and Michel Foucault, the selection of papers shifts the focus to a series of ‘other’ worlds including Navajo, colonial Japan, Indigenous Australia, South America and the African continent. As a result, this book demonstrates that the uptake of a global and apparently globalising technology such as photography elicits a diversity of responses when incorporated into a range of different communities across the world.
Cohort study on the treatment with dapsone 5% gel of mild to moderate inflammatory acne of the face in women.

Field: Medicine (Health Sciences)

Topical dapsone 5% gel for the treatment of mild to moderate acne has been shown to be effective in randomized controlled studies. A total of 101 adult women with mild to moderate facial inflammatory acne participated in a 12-week cohort study to evaluate the efficacy, tolerability, and safety of dapsone gel 5% in this specific group who often complain of sensitive skin. The women were instructed to apply dapsone 5% gel twice daily after washing their face with a standard noncomedogenic soap-free cleanser. Treatment outcome was evaluated using physician-scored Global Acne Assessment Scale (GAAS) and patient-reported facial skin condition. Ninety-three women completed the study (6 were lost to follow-up and 2 had mild skin irritation). At 12 weeks, significant physician GAAS scores (t55 = 8.85, P = .001) and patient-reported lesion reductions were shown. Treatment success (GAAS 0 or 1) at 12 weeks was achieved in 69.4% (n = 75) of women (t94 = 4.17, P = .001), improving patient-reported quality-of-life aspects. Topical dapsone gel 5% was shown to be safe, minimally irritating, and effective in the treatment of mild to moderate inflammatory facial acne in adult women with sensitive skin.
Experiences in Adapting a Source Code-Based Quality Assessment Technology

Field: Computer Science (Physical Sciences)

Testing-based software quality assurance often does not provide an appropriate level of efficiency and reliability. To aid this problem, different kinds of static verification techniques can be applied, like code metrics and code inspection. Many quality assessment methods that are based on static source code analysis has already been proposed, yet these can be used is particular industrial environment - in which often proprietary programming languages are used - only after appropriate adaptation. This paper presents experiences in adapting an existing technology and tools suitable for quality assessment based on source code analysis. The technology has demonstrated its success and usability in industrial environment; being capable of comprehensive and continuous quality monitoring of large and complex software systems involving proprietary technologies.
Continuous Intracisternal and High Cervical Intrathecal Bupivacaine Analgesia in Refractory Head and Neck Pain

Field: Medicine (Health Sciences)

Comment: This study reports on a novel approach to a notoriously difficult pain management problem. There are considerable technical problems to be overcome with insertion and placement of the catheter together with its maintenance in situ. It appears that no major morbidity or mortality was attributed to the method in this small group of patients. Specialist pain management centers could well consider the method for treatment of severe head and neck pain in suitable patients.
Growth Regulation of Vinca minor

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Multiple applications of three rates each of B-Nine/Cycocel, Sumagic, Cutless, and Atrimmec were applied to common periwinkle grown in small containers in a greenhouse to control runner growth. All plant growth regulators (PGRs) suppressed runner elongation throughout the 30-week study. However, Atrimmec at 1500 to 4500 ppm severely injured plants for up to 20 weeks, and Cutless at 30 to 90 ppm reduced the number of runners for at least 24 weeks. There were no adverse effects associated with the application of B-Nine/Cycocel or Sumagic at the rates tested, 2500/1500 to 7500/1500 ppm and 15 to 45 ppm, respectively.
Endoscopic Management for Post-Surgical Complications after Resection of Esophageal Cancer

Field: Medicine (Health Sciences)

Background: Esophageal cancer (EC) is the sixth-leading cause of cancer-related deaths in the world. Esophagectomy is the most effective treatment for patients without invasion of adjacent organs or distant metastasis. Complications and relevant problems may occur in the early post-operative course or in a delayed fashion. Here, innovative endoscopic techniques for the treatment of postsurgical problems were developed during the past 20 years. Methods: Endoscopic treatment strategies for the following postoperative complications are presented: anastomotic bleeding, anastomotic insufficiency, delayed gastric passage and anastomotic stenosis. Based on a literature review covering the last two decades, therapeutic procedures are presented and analyzed. Results: Addressing the four complications mentioned, clipping, stenting, injection therapy, dilatation, and negative pressure therapy are successfully utilized as endoscopic treatment techniques today. Conclusion: Endoscopic treatment plays a major role in both early-postoperative and long-term aftercare. During the past 20 years, essential therapeutic measures have been established. A continuous development of these techniques in the field of endoscopy can be expected.
Rapid Sequence Induction With a Standard Intubation Dose of Rocuronium After Magnesium Pretreatment Compared With Succinylcholine: A Randomized Clinical Trial

Field: Medicine (Health Sciences)

( Anesth Analg . 2021;133:1540–1549) Succinylcholine is the muscle relaxant commonly chosen for rapid sequence induction, despite many adverse effects. Rocuronium bromide, 1.0 to 1.2 mg/kg, can also be used for rapid sequence induction with an onset time comparable to that of succinylcholine, but prolonged recovery time. The onset time of rocuronium may be shortened using magnesium sulfate. This superiority study compared the use of intravenous pretreatment of magnesium sulfate followed by a dose of rocuronium with the use of succinylcholine in terms of intubation conditions.
Communication enabled web applications The evolution of computer telephony integration

Field: Computer Science (Physical Sciences)

Computer Telephony Integration (CTI) allows a computer application to access features from a telephone device or telephony network. Traditional CTI applications are commonly proprietary-based, platform dependent and usually designed and implemented by telephony experts. Whereas the Web started with simple static pages, new models, like the Service Oriented Architecture allow application designers to build complex applications using pre-built, high-level functional services. Next generation CTI should follow this model. Like SOA for the Web, high-level communication services can be built on communication building blocks, enabling complex communication applications to be built. In addition, it should be easy to create Web-based and rich Internet applications that integrate these new communication services. In this paper, we present a web application mashup that uses a high-level communication service and also present experiences from our prototype implementation.
Quantitative phosphoproteomics and multi-omics from technical concepts to patients

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Toward the development of new therapies for personalized medicine Next-generation sequencing technologies are widely used to map the transcriptome of cancers and metabolic diseases. To cover the full spectrum of pathobiochemical processes, multi-omics approaches are increasingly adopted to integrate the genome and transcriptome with the proteomic and metabolomic dimensions.In my PhD thesis, I (i) evaluate the performance of different quantitative methods for tumor tissue phosphoproteomics; (ii) investigate the tumor heterogeneity of ovarian cancer at the level of the phosphoproteome, (iii) characterize the interactome and phosphoproteome of a novel complex involving the metabolic master regulator mTOR (mammalian target of rapamycin) and (iv) map alterations in non-alcoholic fatty liver disease (NAFLD) by integrative multi-omics of the transcriptome, proteome and lipidome.My PhD thesis harnesses the power of phosphoproteomics and integrated multi-omics for the discovery of disease mechanisms linked to the metabolic master regulator mTOR and highly prevalent diseases characterized by complex metabolic alterations (ovarian cancer and NAFLD). Further integration and validation of my findings may open new avenues in personalized medicine.