jimnoneill/paper-to-field-training huggingface dataset:
A Fab fragment directed against the neural cell adhesion molecule L1 enhances functional recovery after injury of the adult mouse spinal cord

Field: Neuroscience (Life Sciences)

Lack of permissive mechanisms and abundance of inhibitory molecules in the lesioned central nervous system of adult mammals contribute to the failure of functional recovery, which leads to severe disabilities in motor functions or pain. Previous studies have indicated that the neural cell adhesion molecule L1 constitutes a viable target to promote regeneration. In the present study, we describe the cloning, functional expression in Escherichia coli cells and purification of a recombinant αL1 Fab fragment that binds to L1 with comparable activity as the function-triggering monoclonal antibody 557.B6 and induces neurite outgrowth and neuronal survival in cultured neurons, despite its monovalent function. Infusion of αL1 Fab into the lesioned spinal cord of mice enhanced functional recovery after thoracic spinal cord compression injury. αL1 Fab treatment resulted in reduced scar volume, enhanced number of tyrosine hydroxylase-positive axons and increased linear density of VGLUT1 (vesicular glutamate transporter 1) on motoneurons. Furthermore, the number and soma size of ChAT (choline acetyltransferase)-positive motoneurons and the linear density of ChAT-positive boutons on motoneurons as well as parvalbumin-positive interneurons in the lumbar spinal cord were elevated. Stimulation of endogenous L1 by application of the αL1 Fab opens new avenues for recombinant antibody technology, offering prospects for therapeutic applications after traumatic nervous system lesions.
Hindrances to Internal Creative Thinking and Thinking Styles of Malaysian Teacher Trainees in the Specialist Teachers’ Training Institute

Field: Arts and Humanities (Social Sciences)

Abstract The aim of this study is to identify hindrances to internal creative thinking and thinking styles of a group of Malaysian teacher trainees from the Specialist Teachers’ Training Institute (N = 232). Three psychological tests were used administrated to the subjects. The result indicates that the ability to think creatively for the majority of subjects (87.50%) is hindered seriously by one of the hindrances to internal creative thinking, that is, stimulus fixity. The finding implies that lecturers of this group of teacher trainees should guide them to overcome this internal barrier before trying to encourage them to think creatively.
Invasive species in phytocenosis of Sterlitamak town (Republic of Bashkortostan, Russia)

Field: Agricultural and Biological Sciences (Life Sciences)

There were 69 invasive and potentially invasive species in the flora of Sterlitamak in the Bashkortostan Republic (Russia). Eight are in the most dangerous types of invasive species. The greatest danger is represented by: Acer negundo, Ambrosia trifida, Elodea canadensis and Xanthium albinum. Within the boundaries of Sterlitamak, 21 syntaxa (13 associations and 8 derivated communities) are invasive species. This phytocenosis in an urban environment can be prime targets for plant quarantine actions.
Self-reflexivity and the Representation of The Indian Diasporic Community in Deepa Mehta’s Bollywood/Hollywood

Field: Arts and Humanities (Social Sciences)

This paper discusses Deepa Mehta’s lighthearted romantic comedy Bollywood/Hollywood as a representation of the Indian diasporic community settled in Canada. What makes this film especially interesting is that it focuses on how, for overseas Indians, Bollywood offers the possibility of accessing the home culture in a globalised world. Bollywood as an industry is synonymous with the genre of family melodrama, and when Mehta uses this term it represents, not just the Bombay Film Industry, but also the cultural iconicity of the genre, which in turn represents the film sensibility of the entire ‘mass’ of Indians located within the country and in the diaspora. At one level, the film is a lighthearted comic portrayal of the Indo-Canadian community in Toronto and its strong connection with “our magnificent Indian culture” (B/H) through the Hindi movies churned out by Bollywood. At a closer look at a number of scenes, light is cast on the way Deepa Mehta emphasizes the cultural divides through interesting narrative and visual constructions. The actual argument of the film emerges in a dialectical reading and recognition of the oppositional forces operating within and without the narrative world. What is particularly striking about this film is its self-reflexivity. It announces itself as a Bollywood melodrama and celebrates this identity. Bollywood is thus positioned as both a subject and an object of contemplation—a world of Cinema that is a part of our memory and a vehicle of history. The critique of the formula also comes from within the formulaic narrative itself. Deepa Mehta constantly uses the genre and also plays around with it in interesting ways
A Quantile Dependence among Exchange Rate, Stock Prices and Oil Prices: An Empirical Evidence from India

Field: Economics, Econometrics and Finance (Social Sciences)

This study investigates the dynamic relationship between exchange rates, oil prices, and stock prices in the Indian market, considering bearish, bullish, and neutral market states. By utilizing the Quantile ARDL method, we explore long- and short-run relationships in differing market states. The variations in sensitivities of oil prices and exchange rates with stock prices across diverse quantiles reflect significant variations in the Indian equity markets. Importantly, our study provides actionable insights for policymakers and stakeholders within India, empowering them with specific strategies for managing currency, stock prices, and oil prices under diverse market states. These insights are not just theoretical but directly applicable to real-world economic and financial decision-making, enhancing the ability of policymakers and stakeholders to navigate the complex Indian market.
IEEE P1687.1: Extending the Network Boundaries for Test

Field: Engineering (Physical Sciences)

Modern integrated circuits used in automotive, industrial, consumer, and IoT (Internet of Things) applications often have limited pin counts. Despite this, these devices can be complex, with significant digital and analog content. These features require rigorous testing to address the quality and reliability requirements of these applications. Because of their limited pin count, a TAP controller interface is often not an option or the TAP controller interface itself may not be an option for other reasons, such as die area. Further, the increasing number of IP based designs, along with the increasing availability of IP cores can result in an IP being integrated deep inside a design. Designers, DfT engineers, and test engineers are facing increasing challenges with the integration and testability of IP in their chips. They also have the task of having to test through interfaces that may change depending on the needs of the customers. IEEE P1687.1 is working on processes that will provide a means for automating communications through non-TAP interfaces, making these types of products ideally suited for the techniques currently under consideration for standardization. This paper, reviews the latest topics being discussed by the working group, including the framework for communicating through these interfaces. It discusses how proto buffers (protobufs) can be used to help bridge the gap between a host controller, like an ATE, and an IJTAG network. The approach leverages the concept of Remote Procedural Calls (RPCs) from the IT space and the integer bit vector (intbv) concept from myHDL to support communications through interfaces and between subroutines handling retargeting and handling control of the interface. A model is presented for evaluating the options and various criteria are reviewed with respect to the framework. The paper also explores debug concerns and potential security issues and how those can be addressed.
Adsorption and Activity ofCandida rugosaLipase on Polypropylene Hollow Fiber Membrane Modified with Phospholipid Analogous Polymers

Field: Chemical Engineering (Physical Sciences)

Efforts have recently been made toward the study of interactions of phospholipid with various enzymes. It seems that phospholipids may be directly involved in regulating the enzyme activity. In this work, three phospholipid analogous polymers (PAPs), containing hydrophobic octyloxy, dodecyloxy, and octadecyloxy groups (abbreviated as 8-PAP, 12-PAP, and 18-PAP, respectively), were tethered on polypropylene hollow fiber microfiltration membrane (PPHFMM) to create a biocompatible interface for lipase immobilization. Lipase from Candida rugosa was immobilized on these PPHFMMs by adsorption. The adsorption capacity, activity, and thermal stability of enzyme on the PAP-modified PPHFMMs were compared with those of enzyme on the nascent ones. It was found that, as for the PAP-modified PPHFMMs, the adsorption capacities of lipase are lower than that of the nascent ones, while the activity retention of immobilized lipase increases from 57.5% to 74.1%, 77.5%, and 83.2% respectively for the 8-PAP-, 12-PAP-, and 18-PAP-modified PPHFMMs. In addition, the experimental results of thermal stability show that the residual activity of the immobilized lipase at 50 degrees C for 2 h is 62% for the 8-PAP-modified PPHFMM, 59% for the 12-PAP-modified PPHFMM, and 66% for the 18-PAP-modified PPHFMM, which are also higher than that of the nascent ones.
Construction of a new plant expression vector and the development of maize germplasm expressing the Aspergillus ficuum phytase gene PhyA2

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Phytases, which belong to a special category of orthophosphoric monoester phosphohydrolases, degrade inositol hexaphosphate to produce lower-grade inositol phosphate derivatives and inorganic phosphate. Thus, phytases may improve phosphorus utilization, eliminate the anti-nutrient properties of phytic acid, and mitigate environmental pollution due to phosphorus contamination. In this study, we constructed a new root-specific expression vector by inserting the Aspergillus ficuum phytase gene PhyA2 into pCAMBIA3301-ZmGLU1P-Nos. The subsequent molecular analysis confirmed that six T 4 generation transgenic plants carried and expressed PhyA2 . A quantitative real-time PCR analysis indicated PhyA2 was highly expressed in the transgenic roots. Additionally, the phytase activity was 10.9-fold higher in the transgenic roots (peak activity of 5.432 U/g) than in the control roots. Moreover, compared with the control rhizosphere, the organic phosphorus content in the rhizosphere of the transgenic plants decreased significantly (by up to 5.21 mg/kg). An agronomic trait analysis indicated that PhyA2 expression can increase maize seed weight by up to 25.8 g. Therefore, the integration of PhyA2 into the maize genome can enhance the ability of maize plants to use the phosphorus compounds in soil, while also improving the plant growth status and increasing the seed yield.
Municipal commonage and implications for land reform: A profile of commonage users in Philippolis, Free State, South Africa

Field: Social Sciences (Social Sciences)

This paper reports on a survey of municipal commonage users, which was undertaken in Philippolis in the southern Free State, in May 2005. The survey showed that a significant number of commonage users are committed to their farming enterprises, as shown by five proxy indicators: Their readiness to plough their income into their farming enterprises; their sale of livestock; their desire for more land, and their willingness to pay rental to secure such land; their desire to farm on their own; and their desire to own their own land. The paper reflects on the significance of commonage in the context of the South African government's land reform policy, and argues that commonage can transcend survivalist or subsistence production, and can be used as a stepping stone for emergent farmers to access their own land parcels. Finally, the paper argues that, if commonage is to become a key part in a step-up strategy of land reform, then appropriately sized land parcels should be made available for commonage users, to enable them to exit from commonage use and invest in smallholdings or small farms.
Erratum: Protease activated receptor 2 in diabetic nephropathy: a double edged sword.

Field: Medicine (Health Sciences)

Diabetic nephropathy is a major microvascular complication of diabetes mellitus, and the leading cause of end stage renal disease worldwide. The pathogenesis of diabetic nephropathy is complex, making the development of novel treatments that stop or reverse the progression of microalbuminuria into end stage renal disease a challenge. Protease activated receptor (PAR)-2 has recently been shown to aggravate disease progression in diabetic nephropathy based upon which it was suggested that PAR-2 would be a potential target for the treatment of diabetic nephropathy. To fully appreciate the translational potential of PAR-2 in diabetic nephropathy, we evaluated the effect of PAR-2 deficiency on the development of diabetic nephropathy in a streptozotocin-induced diabetes model characteristic of type 1 diabetes. Although diabetic PAR-2 deficient mice showed reduced albuminuria compared to diabetic wild type mice, an increase in mesangial expansion was evident in the PAR-2 deficient mice. No differences were observed in blood glucose levels, podocyte numbers or in glomerular vascular density. These results show that PAR-2 plays a dual role in the development of streptozotocin-induced diabetic nephropathy and may thus not be the eagerly awaited novel target to combat diabetic nephropathy. Targeting PAR-2 should consequently only be pursued with great care in a clinical setting.
Constraints faced by the farmers in adoption of drip irrigation system in kinnow cultivation of Punjab and their suggestions

Field: Agricultural and Biological Sciences (Life Sciences)

The present study was undertaken to identify the constraints in adopting the drip irrigation system by collecting data from 100 farmers in four districts of Punjab which were selected purposively i.e. Bathinda, Fazilka, Hoshiarpur and Sri Muktsar Sahib/ Faridkot. Data were collected by following interview schedule approach. The constraints were grouped into four categories viz. economic, market related, technical and extension related constraints. Findings of the study revealed that major constraints faced by the farmers in adoption of drip irrigation system were: uncertainty of power supply, delay in sanction of loan/subsidy followed by lack of credit facilities to farmers, poor after sale services from drip irrigation firms, non-availability of skilled workers for repairing DIS when required, lack of adequate advice and guidance from extension workers and limited help from agricultural department. Facility of regular power supply, flexible and timely provision for loan/subsidy and credit facilities to farmers were suggested by them.
Why narcissistic individuals engage in unethical pro-organizational behavior. Testing a moderated mediation model

Field: Psychology (Social Sciences)

Purpose The purpose of the current research is to study the relationship between narcissism and unethical pro-organizational behavior (UPB), and also examine whether status striving mediates the relationship between narcissism and UPB among individuals with high organizational identification. Design/methodology/approach Data that was used to test the research model were collected from five companies in the trading sector in Tashkent, Uzbekistan. The final sample included 200 responses, among all participants 29.5% were in a leadership position. Findings The current research found that narcissism leads individuals to exhibit a willingness to engage in UPB. Furthermore, status striving mediates the relationship between narcissism and UPB among individuals with high organizational identification. Research limitations/implications Research did not use actual reported UPB but measured employees' willingness to engage in UPB. Practical implications Organizations should develop special ethics guidance to change the employee's perceptions of UPB from the act of helping or protecting the organization to undesirable behavior in the organization. Moreover, the organization may develop an ethical counseling program, by which individuals may perceive that ethical behavior is valuable for the organization. Originality/value Current study examines the relationship between narcissism and UPB. Moreover, it provides empirical support for the notion that the relationship between narcissism and UPB is mediated by status striving among individuals with high organizational identification.
A general framework for pattern-driven modal tableaux

Field: Mathematics (Physical Sciences)

Journal Article A general framework for pattern-driven modal tableaux Get access LF del Cerro, LF del Cerro IRIT - Universit Paul Sabatier, 118 route de Narbonne, Toulouse Cedex 04, France E-mail: farinas, gasquet@irit.fr Search for other works by this author on: Oxford Academic Google Scholar O Gasquet O Gasquet IRIT - Universit Paul Sabatier, 118 route de Narbonne, Toulouse Cedex 04, France E-mail: farinas, gasquet@irit.fr Search for other works by this author on: Oxford Academic Google Scholar Logic Journal of the IGPL, Volume 10, Issue 1, January 2002, Pages 51–83, https://doi.org/10.1093/jigpal/10.1.51 Published: 01 January 2002
Plasma Aβ 42:40 ratio tracks with changes in brain amyloid PET SUVr in the core and open label extension of the phase 2 proof of concept study ban2401‐g000‐201 following treatment with lecanemab in subjects with early Alzheimer’s disease

Field: Medicine (Health Sciences)

Abstract Background Lecanemab (BAN2401) is a humanized IgG1 monoclonal antibody that preferentially targets soluble aggregated Aβ species (oligomers, protofibrils) and insoluble fibrils. Lecanemab reduced the amyloid PET standard uptake value ratio (SUVr) and slowed clinical decline in an 18‐month Phase 2 proof of concept study in early Alzheimer’s disease (Alz Res Therapy 13; 2021). An Open label extension (OLE) with 10 mg/kg IV biweekly lecanemab dosing was implemented after analysis of the Core study, with an intervening gap period off‐treatment ranging from 9‐54 months (mean 24 months). The present study aimed to evaluate longitudinal plasma Aβ 42:40 ratio (C2N PrecivityAD assay) and the relationship to longitudinal amyloid PET in the Core study, gap period, and OLE. Method The amyloid PET sub‐study in the Core study assessed baseline, 12 months and 18 months SUVr with florbetapir, and participants in the OLE amyloid PET sub‐study were imaged at baseline, 3 or 6 months, and 12 months. Plasma samples were collected at the same timepoints and analyzed as described previously (West et al, Mol Neurodegen 2021). Mean changes from Core or OLE baseline and Pearson correlation coefficients were calculated at the group and individual levels for amyloid PET SUVr and plasma Aβ 42:40 ratio, accounting for repeated measures. Result OLE subjects with plasma samples (N=121) were evaluated for this analysis. Lecanemab produced dose dependent reductions in PET SUVr, with corresponding increases in plasma Aβ 42:40 ratio in Core and OLE. In the OLE, reductions in PET SUVr were dependent on OLE baseline SUVr; PET reductions in the OLE were inversely correlated with increases in plasma Aβ 42:40 ratio. Changes in plasma Aβ 42:40 ratio were inversely correlated with changes in PET SUVr at the group and individual levels in the Core (group: r=‐0.939, p=0.0056; individual: r=‐0.49; p<0.0001) and OLE (group: r=‐0.907, p=0.0007; individual: r=‐0.31 p=0.0012) studies. Conclusion Lecanemab dose‐dependent reduction in brain amyloid PET SUVr correlate with increases in plasma Aβ 42:40 ratio. These data align with the OLE clinical data and suggest that plasma Aβ 42:40 ratio has the potential to track the anti‐amyloid effects of lecanemab in AD patients.
Türkiye'de uygulanacak olası bir meme kanseri tarama programının maliyet-etkinlik analizi.

Field: Health Professions (Health Sciences)

Cancer is the second leading cause of death among the world and it has an increasing share among all causes of death. Economical burden of cancer is increasing especially in high and middle-income countries. Leaving cancer in competitive markets would lead to inefficiencies; hence governments should intervene in the market and make public decisions in struggling cancer. Among all cancer types breast cancer has the highest incidence and mortality rates in females. Causes of breast cancer still remains indeterminate and only way to cope with breast cancer are by early diagnoses. Early diagnoses can best be achieved by regular mammography screenings. This study analyzes the possible outcomes of implementing regular breast cancer mammography screening program in Turkey. A simulation model is constructed and run for 10 years, to obtain the costs and benefits of such a screening program. Costs of such a program include the screening costs and costs due to abnormal mammograms. Benefits, on the other hand are reduced treatment costs due to early diagnosis, reduced mortality and morbidity. Simulation model is run for 11 different screening strategies for determining the optimal screening strategy in terms of screening interval and minimum age to screen. The necessary data is obtained from hospital records, Cancer Early Diagnosis and Treatment Center records, IMF, WHO and TUIK databases and literature. Results of the simulation suggest that women over 40 in Turkey should be screened biennially for economical efficiency.
Replication Data for "Go global or go home: Comparing the regional vs. global engagement of Brazil and South Africa at the UN General Assembly"

Field: Social Sciences (Social Sciences)

Original dataset and annex for the manuscript "Go global or go home: Comparing the regional vs. global engagement of Brazil and South Africa at the UN General Assembly". <br/> <br/> Suggested citation: Mesquita, Rafael; Seabra, Pedro. (2020). "Go global or go home: Comparing the regional vs. global engagement of Brazil and South Africa at the UN General Assembly", Politikon. https://doi.org/10.1080/02589346.2020.1796185