jimnoneill/paper-to-field-training huggingface dataset:
MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6–p47 phox –oxidative stress pathway in neutrophils

Field: Medicine (Health Sciences)

Objectives Chronic-plus-binge ethanol feeding activates neutrophils and exacerbates liver injury in mice. This study investigates how recent excessive drinking affects peripheral neutrophils and liver injury in alcoholics, and how miR-223, one of the most abundant microRNAs (miRNAs) in neutrophils, modulates neutrophil function and liver injury in ethanol-fed mice. Designs Three hundred alcoholics with (n=140) or without (n=160) recent excessive drinking and 45 healthy controls were enrolled. Mice were fed an ethanol diet for 10 days followed by a single binge of ethanol. Results Compared with healthy controls or alcoholics without recent drinking, alcoholics with recent excessive drinking had higher levels of circulating neutrophils, which correlated with serum levels of alanine transaminase (ALT) and aspartate transaminase (AST). miRNA array analysis revealed that alcoholics had elevated serum miR-223 levels compared with healthy controls. In chronic-plus-binge ethanol feeding mouse model, the levels of miR-223 were increased in both serum and neutrophils. Genetic deletion of the miR-223 gene exacerbated ethanol-induced hepatic injury, neutrophil infiltration, reactive oxygen species (ROS) and upregulated hepatic expression of interleukin (IL)-6 and phagocytic oxidase (phox) p47 phox . Mechanistic studies revealed that miR-223 directly inhibited IL-6 expression and subsequently inhibited p47 phox expression in neutrophils. Deletion of the p47 phox gene ameliorated ethanol-induced liver injury and ROS production by neutrophils. Finally, miR-223 expression was downregulated, while IL-6 and p47 phox expression were upregulated in peripheral blood neutrophils from alcoholics compared with healthy controls. Conclusions miR-223 is an important regulator to block neutrophil infiltration in alcoholic liver disease and could be a novel therapeutic target for the treatment of this malady.
Form diversity of Japanese barberry (Berberis thunbergii DC.) in the collection and expositions of Kherson state university

Field: Agricultural and Biological Sciences (Life Sciences)

Objective — to evaluate the viability and decorativeness of introduced forms and hybrids of Berberis thunbergii DC. in collections and expositions of Kherson State University. Materials and methods. The object of our study is decorative forms and hybrids of B. thunbergii and their viability in introduction collections and expositions founded in 2002–2005 in Botanical Garden of Kherson State University. We used traditional criteria for evaluating the viability and vital state of plants. Results. We identified the cultivars of B. thunbergii in collections and expositions of Kherson State University, studied their biometrical characteristics, drought resistance and winter hardiness, viability and decorativeness under the conditions of southern arid steppe of Ukraine. The studied cultivars differ in their shape, habit of bushes, size of one-year shoots, leaf colouring, seed production, seed-renewing ability, and drought resistance. The maximal height of bushes reaches 230 cm (B. × ottawensis ‘Auricoma’), and the minimal one is 68 cm (B. thunbergii ‘Bananza Gold’) and 50 cm (B. thunbergii ‘Bagatelle’); the latter has also the smallest diameter of bushes —75–80 cm. The largest diameter of bushes (up to 300 cm) was found for two cultivars: B. × ottawensis ‘Superba’ and B. thunbergii ‘Red Roсket’. The length of one-year shoots strongly varies within a single bush, the biggest rate can reach 145 cm, the least – 1 cm. The studied cultivars essentially differ in number of renewing shoots (turions), which can reach up to 170 cm. We highlighted the six most promising forms, three interspecific hybrids, and one dwarf form for further using them in garden and park landscaping in Southern Ukraine. Conclusion. Among 21 decorative cultivars of B. thunbergii, which were tested in conditions of Botanical Garden of Kherson State University, we highlighted the most promising ones for further using them in garden and park landscaping, namely ‘Green Carpet’, ‘Minor’, ‘Atropurpurea’, ‘Golden Ring’, ‘Red Roсket’, ‘Bagatelle’, interspecific hybrids B. × ottawensis ‘Superba’, ‘Pluriflora’, ‘Auricoma’.
Sydney Long: Deterioration and Improvement of Early Paintings

Field: Arts and Humanities (Social Sciences)

Sydney Long’s painting Pan, 1898, underwent conservation treatment at the Art Gallery of New South Wales in 1994. Examination of the painting and recently found archival material, raised the possibility of the artist reworking Pan some time after it was exhibited at the 1898 Society of Artists Spring Exhibition and acquired directly from this exhibition by the Art Gallery of New South Wales. Sydney Long himself writes about “improving” a number of his paintings at dates after their initial completion, exhibition and sale. The reasons for this are not explicitly stated in the Art Gallery of New South Wales correspondence, although the paintings themselves suggest that it was probably due to premature cracking. Several later letters begin to give a clearer picture of the problems that Sydney Long was forced to confront with the deteriorating condition of these early paintings.
Arrangement of the Life Cycle Cost Influence Factors Based on System Dynamics

Field: Decision Sciences (Social Sciences)

Applying the method of system dynamics theory, the twelve factors that have influence on life cycle cost were analyzed dynamically, and the important extent of the effect that these factors act on life cycle cost was studied. Through simulated calculation and discussion, the magnitude order of the effect that these factors act on life cycle cost was obtained, which can provide significant references for life cycle cost influence factors filtration, bases for life cycle cost calculation modeling of the main factors, and a new way for life cycle cost management decision making.
Propagatory dynamics of electromagnetic drift waves in inhomogeneous spin degenerate compact objects plasmas

Field: Physics and Astronomy (Physical Sciences)

Abstract A theoretical analysis is carried out to investigate the dynamics of electromagnetic drift modes in non-uniform spin quantum magnetoplasmas found in degenerate compact objects. General dispersion relations are derived using spin quantum hydrodynamic equations, Poisson equation, and Maxwell equation, with and without ion inertial effects. The effects of quantum spin magnetization, Bohm potential, and density inhomogeneity on the dispersion of electromagnetic drift modes are explored numerically. The advancing theoretical analysis demonstrated herein has strong correlations and consistencies with the dynamic growth of compact astrophysical objects and their surrounding atmospheres, such as black holes, white dwarfs, and dense molecular clouds.
Trends in age-standardised alcohol-attributable mortality rates by country and sex for ages 30 and older according to different estimation methods, 1972–2017.

Field: Medicine (Health Sciences)

<p>UCOD = ‘Underlying cause of death’, MCOD = ‘Multiple cause of death’, PAF = ‘Population-attributable fraction-based’; Rates expressed per 100,000 person years; The Y-axis scale differs by sex to improve visibility of the results; Data sources: Statistics Finland, Turin Longitudinal Study.</p>
A survey of interdisciplinary participation in medical and pharmaceutical literature.

Field: Health Professions (Health Sciences)

Selected medical and pharmacy journals were reviewed for the years 1966 and 1976 to determine if pharmacists and physicians are publishing more frequently in each other's literature now than they were ten years ago. Three medical journals were reviewed: the Journal of the American Medical Association, the New England Journal of Medicine, and Annals of Internal Medicine. Two pharmacy journals were reviewed: the American Journal of Hospital Pharmacy and Drug Intelligence and Clinical Pharmacy. The total number of articles and letters listing at least one pharmacist as an author was determined for each of the medical journals and the number of articles and letters listing at least one physician as an author was determined for each of the pharmacy journals. In 1966, only one article from any of the three medical journals listed a pharmacist as an author. This number increased to 13 in 1976. The number of letters written in the medical journals by pharmacists increased from only two in 1966 to 31 in 1976. The number of physician-authored articles in the pharmacy journals increased from seven in 1966 to 35 in 1976. The number of letters from physicians remained about the same.
Paramagpy: Software for Fitting Magnetic Susceptibility Tensors Using Paramagnetic Effects Measured in NMR Spectra

Field: Chemistry (Physical Sciences)

Paramagpy is a python module for calculating paramagnetic effects in NMR spectra of proteins. This currently includes fitting of paramagnetic susceptibility tensors to experimental data associated with pseudocontact shifts (PCS) residual dipolar couplings (RDC), paramagnetic relaxation enhancements (PRE) and cross-correlated relaxation (CCR). A GUI allows easy viewing of data and seamless transition between PCS/RDC/PRE/CCR calculations.<br><br>
Long-Term Follow-Up of Autologous Bone Marrow Transplantation in Patients With Relapsed Follicular Lymphoma

Field: Medicine (Health Sciences)

We report the results of high-dose chemoradiotherapy and anti–B-cell monoclonal antibody-purged autologous bone marrow transplantation (ABMT) in patients with relapsed indolent follicular lymphoma. Between March 1985 and May 1995, 153 patients underwent ABMT using a uniform ablative regimen with cyclophosphamide and total body irradiation and bone marrow (BM) purging. All patients received multiple chemotherapy regimens before ABMT. At BM harvest, only 30% of patients were in complete remission, and overt BM infiltration was present in 47%. The disease-free survival (DFS) and overall survival (OS) are estimated to be 42% and 66% at 8 years, respectively. Patients whose BM was negative by polymerase chain reaction (PCR) for bcl2/IgH rearrangement after purging experienced longer freedom from recurrence than those whose BM remained PCR positive (P &lt; .0001). Continued PCR negativity in follow-up BM samples was also strongly predictive of continued complete remission (CR). The 12-year survival from diagnosis for these 153 patients is 69%. Considering that the median survival from diagnosis and first recurrence of patients with advanced follicular lymphoma are 8 and 5 years, respectively, our results provide evidence that myeloablative therapy and ABMT may prolong overall survival.
Fear the taxman. by Adam Schwarz

Field: Economics, Econometrics and Finance (Social Sciences)

tag=1 data=Fear the taxman. by Adam Schwarz

tag=2 data=Schwarz, Adam

tag=3 data=Far Eastern Economic Review,

tag=6 data=16 January 1992

tag=7 data=47,48.

tag=8 data=SOUTH-EAST ASIA%FINANCE-INDONESIA

tag=10 data=Indonesia produces a restrained budget.

tag=11 data=1992/4/2

tag=12 data=92/0091

tag=13 data=CAB
The influence of songwriting on quality of life of family caregivers of people with dementia: An exploratory study

Field: Health Professions (Health Sciences)

Introduction: Living with a person with dementia (PWD) causes physical and psychological problems in family caregivers (FCGs), as well as a reduction in their Quality of Life (QOL). The purpose of this study was to examine the possible effectiveness of the therapeutic songwriting method for improving the QOL and well-being of FCGs of PWD.Methods: The sample of caregivers (n = 21) was divided into three homogeneous groups that received 12 intervention sessions. A non-randomized, quasi-experimental design with repeated measures (pre-post intervention) was employed to determine a possible therapeutic effect. The State-Trait Anxiety Inventory (STAI), Short-Form Health Survey (SF-36v2), Beck Depression Inventory, and Rosenberg Self- Esteem Scale were administered before and after the intervention.Results: The results showed a decrease in anxiety and depression scores and an increase in scores of self-esteem after the intervention. Regarding QOL, post-intervention scores in the Mental Component Summary and Mental Health were significantly higher. In contrast, a small effect size was observed for difference between pre-test and post-test on the subscales of QOL: General Health, Social functioning, Role Emotional and Bodily Pain.Discussion: This exploratory study concludes that therapeutic songwriting can help to reduce caregivers' symptoms of depression and anxiety and improve their perceived self-esteem and QOL. This work reinforces the progress made to date and provides new results that highlight the benefits of music therapy for FCGs of PWD.
Analisis Kualitas Layanan Jaringan Internet di Cv. Asri Jaya Mandiri dengan Metode QoS (Quality Of Service)

Field: Engineering (Physical Sciences)

This study aims to analyze the quality of internet service at CV. Asri Jaya Mandiri using the Quality of Service (QoS) and SERVQUAL methods. QoS measures network performance based on parameters such as throughput, delay, jitter, and packet loss, while SERVQUAL evaluates employees' perceptions and expectations across five dimensions: tangible, reliability, responsiveness, assurance, and empathy. The analysis reveals significant gaps, particularly in reliability and empathy, with unstable connections and inadequate access speed being the primary issues. To improve Service Quality, the study recommends infrastructure upgrades, increased bandwidth, and enhanced communication within the IT team. Implementing these measures is expected to ensure smooth operations, improve employee satisfaction, and enhance the company’s competitiveness.
[Methods of isolation and polypeptide composition of membrane fractions of Rickettsia prowazekii].

Field: Immunology and Microbiology (Life Sciences)

The methods of cell lysis by lysozyme in tris-EDTA-sucrose with the consequent disruption of spheroplasts by the osmotic shock were used to obtain the total membranes from the intact or temperature-inactivated Rickettsia prowazekii. Detergents solubilization methods were used for analysis of outer membrane proteins. Sarcosyl insoluble material is shown to contain the main 134, 31, 29.5 and 25 Kd proteins, the minor 78, 60, 42, 17 Kd proteins, while the mixture of both membranes possess a more complex composition. Treatment of total membranes by the 2% octylglycoside results in elimination of the 31 Kd polypeptide. Inactivated Rickettsia can be used for isolation of the outer layer proteins diminishing the risk of working with this pathogenic microorganism.
Geophysical log characterization of the Flamborough Chalk Formation (Late Cretaceous, Santonian – Early Campanian), East Yorkshire, UK: implications for understanding the onshore and offshore occurrence of the Late Campanian Rowe Chalk Formation

Field: Earth and Planetary Sciences (Physical Sciences)

Whilst borehole geophysical log profiles have been matched with formational subdivisions for large parts of the Chalk Group in Lincolnshire and Yorkshire, characterization of the youngest and thickest part of the outcropping succession, represented by the marl-rich and largely flint-free Flamborough Chalk Formation, has been hindered by lack of cored and geophysically logged boreholes. In the absence of optimal primary data, a stratigraphical interpretation of geophysical logs in the Flamborough Chalk has been developed by comparison of logs from deep hydrocarbons boreholes (penetrating more than 260 m of Flamborough Chalk) beneath Holderness (East Yorkshire) with generalized patterns of outcrop stratigraphy. This approach reveals geophysical log patterns that are consistent with lithology and thickness variations seen at outcrop, compatible with core and geophysical data for a deep borehole in the Flamborough Chalk at Carnaby (near Bridlington), and traceable northwards and westwards towards the margin of the Flamborough Chalk outcrop. These interpretations, and comparisons with geophysically logged offshore successions, suggest the presence of Flamborough Chalk beneath Holderness that is younger (?Late Campanian) than anything seen at outcrop, and, with the exception of possible ex-situ chalk rafts of glacial origin, cast doubt on the likely subsurface onshore extent of typically flint-rich Rowe Chalk Formation.
PROBLEMS AND ARTISTIC FEATURES OF Y. POLYAKOVS ANTI-UTOPIAN STORY "DEMMISTECHKO"

Field: Arts and Humanities (Social Sciences)

кандидат філологічних наук, доцент кафедри міжнародних відносин і політичного менеджменту Державного університету «Житомирська політехніка» У статті розглянуто повість Ю. Полякова «Деммістечко» як таку, котра належить до антиутопічної літератури.Розгляд здійснено у порівнянні повісті з класичними творами означеного жанру -романами Є. Замятіна «Ми» та Дж.Орвелла «1984», -й визначено основоположні риси, що вирізняють твір з-поміж інших антиутопій: створення негативної соціальної побудови з огляду на особливості зображення письменником антиутопічного сьогодення, що засновується на поєднанні реалій радянської минувшини та пострадянської сучасності; окреслено особливості попереджувального пафосу повісті-антиутопії, за допомогою якого автор викриває тоталітарне і псевдодемократичне суспільство й у такий спосіб засуджує минуле і сучасне, зумовлене минулим; зазначено видові риси, які дозволяють віднести повість до жанру антиутопії, як-от: соціологізм, котрий виявляється у створенні негативної соціальної побудови за допомогою фантастики, гротеску, гіперболізації, парадоксальних ситуацій та абсурдизації; універсалізм -розгляд актуальних проблем соціально-політичного й етичного характеру, притаманних усьому пострадянському простору; інтелектуалізм, що з'являється завдяки асоціаціям і паралелям із соціально-політичними реаліями Радянського Союзу й Росії; зазначено риси, які відрізняють повість від класичних творів-антиутопій, зокрема особливий хронотоп, що сприяє негативній репрезентації минулого й сьогодення; своєрідність побудови конфлікту та сюжету, який розгортається за канонами шпигунського детективу; тип героя, котрий є характерним продуктом означених соціальних умов; використання ненормативної лексики, покликаної показати авторське ставлення до зображуваного; окреслено образ Рятівника Вітчизни, котрий асоціюється з образами Благодійника (Є.Замятін «Ми») та Старшого Брата (Дж
Adipocyte Biology

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Adipocytes, the major cell type within adipose tissue, are key endocrine and secretory cells. Not only do adipocytes store fatty acids as fuel, but they also synthesize and secrete a wide range of protein signals and factors, termed adipokines, which are involved in a multiplicity of physiologic and metabolic functions. This involves extensive communication with other tissues and organs, and there is also cross-talk between adipocytes and the other cell types within adipose tissue. Inflammation is a characteristic of obese adipose tissue, with the production and release of a series of inflammation-related adipokines. The inflammatory response is viewed as central to the development of obesity-associated diseases and may be a consequence of local hypoxia as adipose tissue mass expands.
Wesley Robert Wells and the Civil Rights Congress Campaign

Field: Social Sciences (Social Sciences)

During its short existence (1946–55), the Civil Rights Congress (CRC) focused much of its attention on the racist practices of the American criminal justice system. As Gerald Home demonstrates, the CRC's work in publicizing death penalty cases like those of Willie McGee, Rosa Lee Ingram, the Trenton 6, and the Martinsville 7 followed the grassroots tradition of protest established by the International Labor Defense on behalf of the Scottsboro Boys in the 1930s. To be sure, this continuity reflected the work of William L. Patterson, the African American Communist attorney who directed both organizations. Patterson's signal contribution; namely, the use of mass popular pressure to supplement a legal strategy, clearly would be felt long after the demise of the International Labor Defense and the CRC, however. A case first taken up by the CRC, and later revived by the Black Panthers in the late 1960s, vividly illustrates the enduring potential of mass protest as the most effective means of combating racism in the criminal justice system. As seen in the following narration, neither courtroom activism nor executive goodwill would have saved Wesley Robert Wells from the California gas chamber or from a fate sometimes even more "cruel and unusual" than the death penalty.KeywordsDeath PenaltyLegal StrategyBlack Panther PartyPrison OfficialDeath Penalty CaseThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Alternative splicing generates two variants of the alpha 1 subunit of the inhibitory glycine receptor

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The inhibitory glycine receptor (GlyR) in mammalian spinal cord displays pharmacological and molecular heterogeneity of its strychnine binding alpha subunit. Here, cDNAs were isolated which encode a variant (alpha ins 1) of the rat GlyR alpha 1 subunit that contains eight additional amino acids in its putative cytoplasmic domain. Analysis of the corresponding genomic sequence showed that alpha ins 1 transcripts result from alternative splice acceptor site selection. S1 nuclease protection experiments, Northern blot analysis, and RNA amplification by polymerase chain reaction revealed alpha 1 and alpha ins 1 mRNA in postnatal spinal cord, but not in other brain regions. Expression of synthetic alpha ins 1 RNA in Xenopus oocytes generated glycine-gated strychnine-sensitive chloride channels. These data indicate that alternative splicing contributes to GlyR alpha subunit heterogeneity in the mammalian central nervous system.
Postoperative Hospital Retention Following Ambulatory Surgery in a Hospital-Based Program

Field: Health Professions (Health Sciences)

In an effort to learn more about resource utilization on ambulatory surgery in hospital departments of surgery and its impact on quality of care, we re viewed the causes of postoperative hospital retention following ambulatory surgery in a hospital-based program. Of 1971 patients operated on in a 6-month period, 188 were retained for a rate of 9.5%. Of these, 71 (3.6%) were retained for observation and 42 (2.1%) for surgery more extensive than planned. The remaining 75 (3.8%) patients represent complications of surgery or anesthesia. The age distribution of pa tients with complications was the same as the group overall with a single mode at about 30 years, while the distribution of patients retained for observation or who were admitted the day of surgery was bimodal with a second peak at about 70 years. All surgical specialties had comparable rates of postoperative re tention, except gynecology which was significantly lower. Many of the patients had multiple procedures or surgery more extensive than planned.