jimnoneill/paper-to-field-training huggingface dataset:
Missing Miss Stein and Hating Yale

Field: Arts and Humanities (Social Sciences)

Abstract Returned to Englewood, George launches As Stable pamphlets with Gertrude Stein’s “Descriptions of Literature.” Planning other titles, George next prints Ernest Hemingway’s irreverent “Today Is Friday.” Its cover drawing by the voluble gay Jean Cocteau displeases the writer, offended to be implicated in a project involving “fairies.” Meanwhile, George briefly holds a lowly job at Brentano’s bookstore, even while proposing projects to keep him tethered to Gertrude Stein. She and George correspond frequently, but his equanimity wilts under the challenges of literary publishing. He follows modernist cultural trends, however, through the Manhattan salon of the eccentric Muriel Draper, whose bohemian gatherings approximate the daring of Paris’s Left Bank. At Draper’s, George becomes reacquainted with his Berkshire schoolmate, Lincoln Kirstein. In the fall of 1926, George is enrolled at Yale, but barely lasts the first semester. The conventionality of the male undergraduates appalls him. Instead, he plans a bookstore modeled on Sylvia Beach’s Shakespeare & Company.
Family Planning in London Teaching Hospitals

Field: Medicine (Health Sciences)

MEBIClJOURNALtainly pointed to the atrophic kidney as the leading suspect.The history of polyuria (nocturia) at the onset of the patient's symp- toms, however, would suggest the possible role of increased aldosterone secretion.The values of serum sodium and potassium would therefore be of some interest.The malignant phase of the disease is against primary aldosteronism,' but would appear not to be completely inconceivable or incompatible.!
Management of chronic constipation in adults

Field: Medicine (Health Sciences)

Chronic constipation (CC) is an extremely common condition with an estimated prevalence of up to 24%. Most patients with CC should be treated in primary care. Changes in lifestyle, including increased intake of dietary fibre, fluid, and exercise, should be attempted in most patients. Osmotic or stimulant laxatives are indicated if there are insufficient effects of lifestyle changes. Prokinetics and secretagogues should be restricted to those not responding to basic treatment. Anorectal physiology tests and assessment of colorectal transit time are indicated if medical treatment fails or if symptoms indicate severely obstructed defecation. If symptoms indicate an underlying structural disorder, barium or magnetic resonance evacuation proctography is indicated. Biofeedback therapy is effective in patients with dyssynergic defecation. In patients with other evacuation disorders, rectally administered laxatives or transanal irrigation should be attempted. Surgery is restricted to the minority of CC patients with very severe symptoms not responding to conservative treatment.
A Computational Approach to Investigate the HDAC6 and HDAC10 Binding Propensity of Psidium guajava-derived Compounds as Potential Anticancer Agents

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background: Different parts of Psidium guajava are consumed as food and used for medicinal purposes around the world. Although studies have reported their antiproliferative effects via different biochemical mechanisms, their modulatory effects on epigenetic modification of DNA molecules via histone deacetylases (HDACs) are largely unknown. Objective: This study was carried out to investigate the histone deacetylase 6 (HDAC6) and histone deacetylase 10 (HDAC10) binding propensity of guava-derived compounds, using in silico methods, in other to identify compounds with HDAC inhibitory potentials. Methods: Fifty-nine guava-derived compounds and apicidin, a standard HDAC inhibitor, were docked with HDAC6 and HDAC10 using AutodockVina after modeling (SWISS-MODEL server) and validating (ERRAT and VERIFY-3D) the structure of HDAC10. Molecular interactions between the ligands and the HDACs were viewed with Discovery Studio Visualizer. Prediction of binding sites, surface structural pockets, active sites, area, shape and volume of every pocket and internal cavities of proteins was done using Computed Atlas of Surface Topography of proteins (CASTp) server, while absorption, distribution, metabolism, and excretion (ADME) study of notable compounds was done using Swiss online ADME web tool. Results: 2α-hydroxyursolic acid, asiatic acid, betulinic acid, crategolic acid, guajadial A and B, guavacoumaric acid, guavanoic acid, ilelatifol D, isoneriucoumaric acid, jacoumaric acid, oleanolic acid, psiguadial A, B, and C demonstrated maximum interaction with the selected HDACs. ADME studies revealed that although isoneriucoumaric and jacoumaric acid ranked very high as HDAC inhibitors, they both violated the Lipinski’s rule of 5. Conclusion: This study identified 13 drugable guava-derived compounds that can be enlisted for further studies as potential HDAC6 and HDAC10 inhibitors.
Differentiated resilience for anycast flows in MPLS networks

Field: Computer Science (Physical Sciences)

This work investigates a differentiated resilience scheme for anycasting flows in the context of an MPLS network. The proposed resilience scheme allows anycast flows to survive both link and server failures. Three classes of survivability are considered (dedicated protection, shared protection and restoration). The performance of the different traffic classes is examined through simulation. Performance is compared with and without the rerouting algorithm. The effect of deploying different number of servers is also examined.
Relationships Between Implicit Power Motivation, Implicit Sexual Motivation, and Gonadal Steriod Hormones: Behavioral, Endocrine, and fMRI Investigations in Humans.

Field: Psychology (Social Sciences)

The present research explored relationships between individual differences in motivational states (basal testosterone levels (study 1), implicit power motivation (study 2), implicit sexual motivation (study 3)) and both biology and behavior (brain responses to dominance signals (study 1), steroid hormone levels (study 2), and operant conditioning (study 3).\n\n\tTestosterone is positively linked to dominance behavior in men. However, little is known about the moderating effects of testosterone in the human brain in the context of dominance. Study 1 used fMRI to measure amygdala BOLD response to interpersonal dominance signals of threat (anger faces) as a function of endogenous testosterone levels in 24 participants (10 men). Men’s, but not women’s, amygdala BOLD response to anger faces was negatively correlated with their endogenous testosterone levels. \n\n Study 2 investigated basal and dynamic relationships between implicit power motivation (n Power) and both salivary estradiol and testosterone in women. During a laboratory dominance contest, participants competed in pairs on a cognitive task and contest outcome (win vs. loss) was experimentally varied. Estradiol and testosterone levels were determined in saliva samples collected at baseline and several times post-contest, including one day post-contest. n Power was positively associated with basal estradiol concentrations. Women’s estradiol responses to a dominance contest were influenced by the interaction of n Power and contest outcome: Estradiol increased in power-motivated winners but decreased in power-motivated losers. Lastly, n Power and estradiol did not correlate with self-reported dominance and correlated negatively with self-reported aggression. Self-reported dominance and aggression did not predict estradiol changes as a function of contest outcome. Overall, n Power did not predict basal testosterone levels or testosterone changes as a function of dominance contest outcome.\n\n In study 3, using a newly-created method, implicit sexual motivation themes were coded in participants’ creative stories. To assess the predictive validity of coding implicit sexual motivation in creative stories, an operant conditioning paradigm was employed, which assessed the rewarding properties of visual sexual stimuli. Implicit sexual motivation was positively associated with implicit learning to achieve visual sexual reward, and this effect was particularly strong in men.
Continuity of care and delivery of diabetes and hypertensive care among regular users of primary care services in Chile: a cross-sectional study

Field: Health Professions (Health Sciences)

Objectives Explore factors related to continuity of care and its association with diabetes and hypertensive care, and disease control. Design Cross-sectional study. Setting Data from the Chilean Health National Survey 2009–2010. Participants Regular users of primary care services aged 15 or older. Primary and secondary outcome measures Proportion of hypertensive and diabetic patients with a blood pressure <140/90 mm Hg and HbA1c<7.0% respectively, self-report of diagnosis, treatment and recent foot and ophthalmological exams. Associations between continuity of care, sociodemographic characteristics, and primary and secondary outcomes were explored using logistic regression. Results 3887 primary care service users were included. 14.7% recognised a usual GP, 82.3% of them knew their name. Continuity of care was positively associated with age >65 years (OR 4.81, 95% CI 3.16 to 7.32), being female (OR 1.66, 95% CI 1.34 to 2.05), retired (OR 2.22, 95% CI 1.75 to 2.83), obese (OR 1.66, 95% CI 1.29 to 2.14), high cardiovascular risk (OR 2.98, 95% CI 2.13 to 4.17) and widowed (OR 1.50, 95% CI 1.13 to 1.99), and negatively associated with educational level (8–12 vs <8 years OR 0.79, 95% CI 0.64 to 0.97), smoking (OR 0.65, 95% CI 0.52 to 0.82) and physical activity (OR 0.76, 95% CI 0.61 to 0.95). Continuity of care was associated with diagnosis awareness (OR 2.83, 95% CI 1.21 to 6.63), pharmacological treatment (OR 2.04, 95% CI 1.15 to 3.63) and a recent foot (OR 3.17, 95% CI 1.84 to 5.45) and ophthalmological exam (OR 3.20, 95% CI 1.66 to 6.18) in diabetic but not in hypertensive patients. Conclusions Continuity of care was associated with higher odds of having a recent foot and ophthalmological exam in patients with diabetes, but not with better diseases control. Findings suggest patients with chronic conditions have better continuity of care access.
Comment on essd-2022-467

Field: Environmental Science (Physical Sciences)

Abstract. Estuarine dynamics are highly complex as a result of the temperature and salinity gradients, as well as the multiple interactions between atmospheric, maritime, and hydrological forcing agents. Given the environmental and socioeconomic importance of estuaries and their current and future threats due to human interventions and climate change, it is of vital importance to characterize these dynamics, monitor their evolution, and quantify the expected impacts derived from climate change. This paper presents a hybrid database combining data obtained in six field surveys (in 2012, 2013, and 2015) and results from a physically based 3D numerical model for the Bay of CÃ¡diz (southern Spain), a highly anthropized mesotidal estuary. The 3D dataset includes water levels, currents, density, and wave climate, allowing for an analysis of bay dynamics at different timescales ranging from intratidal processes to seasonal variabilities. The results offer an example of the potential uses of the dataset and include (1) an assessment of the spatial and seasonal variability of the estuarine dynamics and (2) an analysis of the effects of severe weather events. These examples provide convincing evidence regarding how the dataset can be employed in multiple research fields and applications, including oceanâbay interactions, water exchange between basins, longwave and shortwave propagation along creek systems, and energy extraction of tidal waves. Therefore, this hybrid dataset may be of significant interest for stakeholders and scientists from different sectors (water engineering, ecology, urban development, energy, etc.) working on the environmental management of the Gulf of CÃ¡diz and other tidally dominated shallow bays. It can also serve as a benchmark test for numerical hydrodynamic models, infrastructure intervention assessments (e.g., dikes or breakwaters), or renewable energy conversion system models. The dataset is available at https://doi.org/10.5281/zenodo.7484186 (Zarzuelo etÂ al.,Â 2022b).
Prevention of postoperative deep venous thrombosis

Field: Medicine (Health Sciences)

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Light‐Directed Microalgae Micromotor with Supramolecular Backpacks for Photodynamic Therapy

Field: Medicine (Health Sciences)

Abstract In recent years, the development of micromotors for biomedical applications has surged. However, challenges such as immunogenicity and the difficulty in controlling motion direction have hindered their clinical translation. In this study, Chlamydomonas reinhardtii, a natural unicellular green microalgae known for its biocompatibility and phototaxis properties in hydrogen peroxide environments is applied, as a micromotor for efficient drug delivery and photodynamic therapy. 5‐Aminolevulinic acid‐loaded liposomes are anchored onto the surface of algae through host–guest complexation between β‐cyclodextrin‐modified algae and adamantane‐modified liposomes. This created a micromotor capable of carrying a drug‐loaded backpack for light‐driven tumor targeting and drug delivery. Additionally, light irradiation activates the photosynthesis of chloroplasts in microalgae leading to oxygen production and alleviation of the tumor's hypoxic microenvironment. In tumor‐bearing mice, light irradiation on tumor tissue directs the micromotor to accumulate in the tumor region, significantly increasing the local drug concentration from 0.007 to 0.069 mg mL −1 compared to free liposomes. Furthermore, oxygen generated from photosynthesis enhances the efficacy of photodynamic therapy, resulting in complete tumor regression in Balb/c mice after 14 days. This system achieves a three‐in‐one effect, combining targeted drug delivery, oxygen generation, and photodynamic treatment. These findings hold promise for the advancement of micromotor‐based biomedical applications.
A Review on Design and Analysis of Switch UAV based on Slam Network

Field: Engineering (Physical Sciences)

The project aims at designing, modelling and analysis of a fixed wing vertical take of landing (VTOL) UAV (Transitional aircraft), (Hybrid drone) and evaluate its performance of airfoil at different angle of attacks.The aircraft possess the merits of fixed wing aircraft which includes high speed, endurance and range and (VTOL) which includes hovering capability and precise low speed flight response which is extremely helpful in remote areas.The CAD modelling of the UAV is done with help of CATIA software The mathematical modelling is done using MATLAB & SIMULINK analysis of the airfoil using ANSYS (CFD simulation).Ultimately the project aims to develop a high-performance UAV that can take off and land vertically while providing efficient forward flight capabilities where the UAV is required to operate in harsh and extreme environmental conditions.
Achieving Bologna Goals: Where Does Europe Stand Ahead of 2010

Field: Social Sciences (Social Sciences)

Ten years have passed since the signature of the Bologna declaration. Seventeen countries have joined the process; since then, several new action lines have been added and the original action lines have often gained a new and more sophisticated content. The 2009 Bologna Stocktaking exercise included the traditional quantitative indicators, the criteria this time being designed to evaluate the goals set for 2010. In addition, particular emphasis was put on qualitative analysis on this occasion to provide a realistic picture of what has been achieved and which initiatives will take more time than anticipated to implement. The 2009 stocktaking shows that while there has indeed been important progress since 1999, following progress since 2007, not all the goals of the Bologna Process will be achieved by 2010.
Dos Nuevas Especies de Phrynopus (Anura: Leptodactylidae) de Los Bosques Nublados de Bolivia

Field: Agricultural and Biological Sciences (Life Sciences)

We describe two new species of Phrynopus from cloud forests in Cochabamba, Bolivia. The new species are assigned to the P. peruanus group and are characterized by the presence of basal webbing, distinctive coloration, and by having the first finger shorter than the second. The first of these new species was collected near Montepunko in Parque Nacional Carrasco and is known from eight males and six females. Among its distinctive characteristics are round cream-colored glands on its flanks. A second species is known from one male and one female collected near "Zona de Aguirre" near the northwest border of the park. V and X-shaped blotches and a dorsum that is smooth except for dorsolateral and scapular folds characterize this species. Musculature has rarely been described for species of Phrynopus. The species from Montepunko has unusual gular and thigh musculature that is quite unlike other species of the genus.
Why Shared Understanding Matters -- Engineering a Collaboration Process for Shared Understanding to Improve Collaboration Effectiveness in Heterogeneous Teams

Field: Decision Sciences (Social Sciences)

Solving complex problems often requires experience and perspectives of various, often heterogeneous experts. Shared understanding of the task is an important determinant for the performance of collaborative groups [1, 2]. Surprisingly little attention has been paid to the systematic development of processes that lead to a shared understanding within heterogeneous groups. To address this challenge, we provide a systematic, reusable process to support groups to converge towards a shared understanding of a task to be then able to collaborate more effectively and efficiently. To achieve the proposed goal, we develop a collaboration process grounded in theory based design guidelines, including activities for individual (1) and collaborative construction of meaning (2) as well as constructive conflict resolution (3). We ground our work in group cognition research and apply a collaboration engineering approach [3]. We test the process design in a computer-aided requirements elicitation workshop with experts from different professional backgrounds. We identify strengths and limitations of the process design to enable the development of think Lets (reusable design patterns for collaboration engineering) for shared understanding in future research.
Large woody debris “rewilding” rapidly restores biodiversity in riverine food webs

Field: Environmental Science (Physical Sciences)

Abstract Extensive habitat destruction and pollution have caused dramatic declines in aquatic biodiversity at local to global scales. In rivers, the reintroduction of large woody debris is a common method aimed at restoring degraded ecosystems through “rewilding.” However, causal evidence for its effectiveness is lacking due to a dearth of replicated before–after control‐impact field experiments. We conducted the first replicated experiment of large woody debris rewilding across multiple rivers and organisational levels, from individual target species populations to entire food webs. For the first time, we demonstrate causal links between habitat restoration, biodiversity restoration and food web responses. Populations of invertebrates and an apex predator, brown trout ( Salmo trutta ), increased, and food web analysis suggested increased biomass flux from basal resources to invertebrates and subsequently fishes within restored reaches. Synthesis and applications . This study contributes significant new evidence demonstrating that large woody debris rewilding can help to restore human‐impacted river ecosystems, primarily through altering the abundance and biomass of consumers and resources in the food web. We also outline a means to gauge the magnitude of ecological responses to restoration, relative to environmental stressors, which could help to prioritise the most effective conservation efforts.
Control of Leafminer Larvae in Chrysanthemum, California, OCT. 1984

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Standardized 3-leaved potted mum plants (10 per treatment) were exposed to adult leafminers 7 days prior to insecticide application. Larval mine counts were made prior to pesticide treatment. The materials were applied to the plants to runoff, with a 1-gal B&G sprayer, with a Spraying Systems 5003 nozzle, at 55 psi on Oct. 30 (T = 16.8-17.2°C). The mum plants were cut at the base after the materials had dried and just prior to emergence of the larvae from the mum leaves. The plants were placed on a layer of sand in individual petri dishes, where the larvae exited the leaves, dropped to the sand and pupated. The petri dishes were held at constant 26.7°C. After pupation, the sand was sifted to collect the pupae which were counted and held at 26.7°C for adult emergence. The spreader sticker, Triton X-100 was added to all treatments at the rate of 1 ml/gal.
Cigarette lighter heating of <i>S</i>. <i>aureus</i>-"spiked" Hydromorphone-CR prepared in cookers/filters decreases the bacterial burden in the injected drug solution.

Field: Medicine (Health Sciences)

<p><i>S</i>. <i>aureus</i>-spiked samples in Hydromorphone-CR-containing Cookers/Filters were heated with a cigarette lighter (holding the flame under the cooker until bubbling) during either the initial wash or at the subsequent 1-hour or 24-hour second wash. Heating reduced <i>S</i>. <i>aureus</i> bacterial recovery by approximately 2 log10 when performed immediately after bacterial contamination, but delayed heating was less effective. Significance was assessed by one way Anova with Tukey’s correction for multiple comparisons. **P<0.01, ***P<0.001, NSD indicates no statistically significant difference.</p>
HIP PROSTHESIS RESURFACING: MECHANICAL CONSEQUENCES OF FEMORAL IMPLANT POSITIONING

Field: Medicine (Health Sciences)

Purpose of the study: Hip resurfacing with a metal-on-metal bearing gives good mid-term clinical results. The design of the femoral piece has an effect on implant longevity, as does the vitality of the underlying cephalic bone. Computer-assisted surgery has been helpful in position the implant but the choice of the best position is still empirical. Prosthesis designers recommend valgus, but with too much there is a risk of a superolaterl notch which would weaken the neck. This leads the surgeon to use a larger femoral implant, and consequently to resect more acetabular bone. Anteversion is not evaluated. The purpose of this study was test mechanically different valgus/varus, anteversion/retroversion positions of the femoral implant. Material and methods: We implanted 15 femurs made of resin which were geometrically and mechanically identical. The following angles were tested: varus/valgus (−10°, neutral, +10°, +20°) and ante/retroversion (−10°, neutram, +10). A valgus notch (+20° and +10°) and a varus notch (−10°) were simulated. The femurs thus prepared were tested with Instron 8874. Load at failure was noted as well as the type of fracture: distance from the fracture line to the greater trochanter (FGT). Student’s t test was applied. Results: All of the femurs fractured at the neck. The fracture was closer to the implant (FGT: 11.0 mm) for the 20° valgus implantation (p Discussion: This study, unlike clinical studies, did not demonstrate any static mechanical superiority of the valgus position for the femoral piece. Another study on cadaver bones is planned for confirmation. Clinical studies reflect the vitality of the trabecular bone supporting the implant, a vitality which could be stimulated by the valgus position.