jimnoneill/paper-to-field-training huggingface dataset:
Isolation of 2R,5R-Dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) from the Fermentation Broth ofStreptomycessp. KSC-5791

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Journal Article Isolation of 2R,5R-Dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) from the Fermentation Broth of Streptomyces sp. KSC-5791 Get access Satoshi Watanabe, Satoshi Watanabe Life Science Research Institute, Kumiai Chemical Industry Co., Ltd., 3360 Kikugawa-cho, Ogasa-gun, Shizuoka 439, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideki Kato, Hideki Kato Life Science Research Institute, Kumiai Chemical Industry Co., Ltd., 3360 Kikugawa-cho, Ogasa-gun, Shizuoka 439, Japan Search for other works by this author on: Oxford Academic Google Scholar Kouzo Nagayama, Kouzo Nagayama Life Science Research Institute, Kumiai Chemical Industry Co., Ltd., 3360 Kikugawa-cho, Ogasa-gun, Shizuoka 439, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Abe Hiroshi Abe Life Science Research Institute, Kumiai Chemical Industry Co., Ltd., 3360 Kikugawa-cho, Ogasa-gun, Shizuoka 439, Japan Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 59, Issue 5, 1 January 1995, Pages 936–937, https://doi.org/10.1271/bbb.59.936 Published: 01 January 1995 Article history Received: 20 October 1994 Published: 01 January 1995
Supplemental Material: Miocene stratigraphy and structure of the East Bay Hills, California

Field: Earth and Planetary Sciences (Physical Sciences)

Supplemental Materials: 1: Correlation of the Monterey and San Pablo Groups in the East Bay; 2: Ages and correlations of the Contra Costa and San Pablo; 3: The Indian Valley member of the Moraga Formation; 4: Map distribution of the Upper San Pablo Group and Lower Orinda member and inferred displacement across the Divide Ridge fault zone; 5: Analytical data for radiometric dates; and 6: Plate 1: Geologic map of Miocene rocks of the East Bay.
Professionalism, golf coaching and a Master of Science degree: A commentary

Field: Social Sciences (Social Sciences)

The expansion of sporting organisations, like the Professional Golfers’Association (PGA) of America and the establishment of International partnerships, like the PGA World Alliance provide evidence for the continued professionalization of golf. Nevertheless, despite the founding of a number of organisations that support the education of golf teachers, there is currently a paucity of programs that specialise in the advancement of golf coaches. While the terms “teacher” and “coach” are often used synonymously in day-to-day life, the World Golf Coaches Alliance (WGCA) outlines that golf coaches help golfers to compete either individually or as part of a team, while golf teachers provide instruction on how to play the game. The stimulus article by Dr. Simon Jenkins provides evidence that effective coaching requires a balanced approach that brings together the science and art of golf and outlines a framework for a proposed Master of Science in Golf Teaching/Coaching program.
Distinct prophase arrest mechanisms in human male meiosis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

To prevent chromosomal aberrations to be transmitted to the offspring, strict meiotic checkpoints are in place to remove aberrant spermatocytes. However, in about 1% of all males these checkpoints cause complete meiotic arrest leading to azoospermia and subsequent infertility. We here unravel two clearly distinct meiotic arrest mechanisms that act during the prophase of human male meiosis. Type I arrested spermatocytes display severe asynapsis of the homologous chromosomes, disturbed XY-body formation and increased expression of the Y-chromosome encoded gene ZFY and seem to activate a DNA damage pathway leading to induction of p63, possibly causing spermatocyte apoptosis. Type II arrested spermatocytes display normal chromosome synapsis, normal XY-body morphology and meiotic crossover formation but have a lowered expression of several cell cycle regulating genes and fail to properly silence the X-chromosome encoded gene ZFX. Discovery and understanding of these meiotic arrest mechanisms increases our knowledge on how genomic stability is guarded during human germ cell development.
A Critique of Debt Financing for Local Governments

Field: Economics, Econometrics and Finance (Social Sciences)

The dichotomy between pay-as-you-go (taxation financing) and pay-as-you-use (debt financing) methods of financing municipal projects, etc, is the area of concern in this paper. While there arc advantaees and disadvantages to both forms, debt financing carries a considerable amount of baggage known as interest. Interest or usury has been a concern of economic and religious thinkers through the ages. Given the potentially negative effect this has on the debtor, Indonesia is forewarned as it decentralizes fiscal administration to local governments. Besides reliance on taxation financing, an alternative public debt option is highlighted.
Systematic analysis of the clinical and biochemical characteristics of maternally inherited hypertension in Chinese Han families associated with mitochondrial

Field: Medicine (Health Sciences)

Mitochondrial DNA mutations may be associated with cardiovascular disease, including the common cardiac vascular disease, hypertension. In this study we performed segregation analysis and systematically evaluated the entire mitochondrial genome in nine maternally inherited hypertension probands from Chinese Han families. We also performed clinical, genetic and molecular characterization of 74 maternally inherited members from these families and 216 healthy controls. In the maternally inherited members, 12 had coronary heart disease (CHD), six had cerebrovascular disease, five had diabetes, nine had hyperlipidemia and three had renal disease. Laboratory tests showed that the sodium and potassium levels in blood of the maternally inherited members were higher than those of the control group (P < 0.01), while no differences were observed in fasting blood glucose (FBG), total cholesterol (TC), triglyceride, low density lipoprotein cholesterol (LDL-c) and creatinine levels (P > 0.05). The high density lipoprotein cholesterol (HDL-c) level of the maternally inherited members was lower than that of the control group (P = 0.04). The whole mitochondrial DNA sequence analysis revealed a total of 172 base changes, including 17 in ribosomal RNA (rRNA) genes, four in transfer RNA (tRNA) genes, and 22 amino acid substitutions. The remainder were synonymous changes or were located in non-coding regions. We identified seven amino acid changes in the nine maternally inherited hypertension families, including four mutations in ATPase6 and three in Cytb. More interestingly, tRNASer(UCN) 7492 T > C was absent in controls and was present in <1% of 2704 mtDNAs, indicating potential functional significance. This study showed that mutations in mtDNA may contribute to the pathogenesis of hypertension in these Chinese Han families. In the near future, identification of additional mtDNA mutations may indicate further candidate genes for hypertension.
Tarnishing of AuAgCu alloys. Choice of an accelerated test

Field: Materials Science (Physical Sciences)

Abstract Three tarnish‐testing procedures were applied to three 14 and 18 ct AuAgCu and one 14 ct AuAgCuZn alloys widely used in decorative applications. Two gaseous phase tarnishing tests were investigated: the flower of sulphur test carried out at 50 °C and 75% relative humidity for 5 days, and the thioacetamide test performed at ambient temperature and 75% relative humidity for 5 days. In addition, a liquid based method known as the Tuccillo‐Nielsen test where the samples are alternatively immersed in an aqueous sulphide solution for 3 h was also studied. It was found that the general tarnishing aspect encountered in field trials was better reproduced in the liquid medium than in the gas phase tests. The colorations are more heterogeneous in the liquid test. The main advantage of the Tuccillo‐Nielsen test is that it requires only 3 h, but it can give rise to galvanic effects and may be difficult to apply to any forms of finished products. The thioacetamide test gave poorly reproducible and reliable results. In addition the colour changes after 5 days' exposure were small; moreover, thioacetamide is a carcinogen. The flower of sulphur test yielded large, reproducible colour changes. It should be preferred to the thioacetamide test for the accelerated testing of silver – and copper‐containing alloys.
Effect of essential oils and selected components on Heterorhabditis amazonensis Andaló et al. strain HC1

Field: Agricultural and Biological Sciences (Life Sciences)

The effect of four essential oils and eleven selected components on the infective juveniles (IJ) of the
entomopathogenic nematode Heterorhabditis amazonensis Andaló et al. strain HC1 was studied under laboratory conditions.
Susceptibility of this strain to seven organic solvents and surfactants was determined. The lethal and sublethal toxic effects on
IJ exposed directly to the essential oils and components were evaluated in 24 well plates for 24 h. Data of lethal toxic effects
were subjected to ANOVA and the means compared by Duncan´s multirange test at 0,05 %, whereas data of sublethal toxic
effects were analyzed by the multiple comparison of proportions (Wald´s Method, confidence level of 0,05). Toxicity of
Triton X-100 at 0,5 % on H. amazonensis strain HC1 was low and could be used in bioassays of chemical product
compatibility with this nematode strain. The essential oils of Melaleuca quinquenervia (Cav) S.T. Blake and Citrus sinensis
(L.) Osbeck caused no significant lethal toxic effect on IJ of H. amazonensis (strain HC1), while those of Piper aduncum
subsp. ossanum (C. DC.) Saralegui and Piper auritum Kunth produced moderate mortality. No sublethal effects were caused
by these four oils on the infectivity of IJ of H. amazonensis strain HC1. The essential oil components camphene, p-cymene
and piperitone did not affect IJ of H. amazonensis strain HC1; 1,8-cineole, limonene, camphor, and methyl chavicol showed
moderate toxicity, and carvacrol, eugenol, linalool, and thymol were highly toxic. According to the parameters evaluated, the
essential oils from M. quinquenervia and C. sinensis and the components camphene, p-cymene, and piperitone were
compatible with H. amazonensis strain HC1.
Monoalkylation of primary aromatic amines via N-(alkoxymethyl)aryl amines. Evidence for the formation of stable monomeric methyleneamines

Field: Chemistry (Physical Sciences)

J. Barluenga, A. M. Bayón and G. Asensio, J. Chem. Soc., Chem. Commun., 1983, 1109 DOI: 10.1039/C39830001109
EFFECTIVENESS OF FOOT REFLECTION MASSAGE THERAPY CONTROLLING BLOOD PRESSURE PATIENTS HYPERTENSION IN THE FAMIL

Field: Health Professions (Health Sciences)

Hypertension is a chronic condition characterized by increased blood pressure on the walls of the arteries. Interventions for hypertension sufferers can be controlled by providing pharmacological and non-pharmacological therapy, one of which is foot reflexology massage. This therapy is massaging the reflex points on the feet which is done by rubbing slowly and regularly to increase relaxation and control blood pressure. This Systematic Review aims to identify effectiveness of massage therapy foot sole reflexology in controlling blood pressure in hypertensive patients in the family. Search for articles using databases including: PubMed and Google Scholar with inclusion criteria, namely: full text, in the period 2019-2024, has a DOI, Randomized Control Trials (RCT) research type. From the literature search, 6 articles were obtained that met the criteria for conducting the study. The six articles state that providing foot reflexology massage can control blood pressure, reduce stress and improve the quality of life of hypertension patients in the family. Foot reflexology massage is effective for controlling blood pressure and improving the quality of life for patients and their families.
Supporting m-commerce transactions incorporating locational attributes: an evaluation of the comparative performance of a location-aware method of locations repository management

Field: Computer Science (Physical Sciences)

The growth in value of economic activity associated with e-commerce transactions is now a firmly established trend. Mobile commerce (m-commerce) has recently emerged as a significant and growing segment of e-commerce and is increasingly the subject of application development activities and the object of escalating levels of business investment. An integral component of many m-commerce applications is a repository containing location-related information (attributes) on service-providing or goods-producing organisations. Rapid access to an organisation's locational attributes is an important determinant of the level of service realised by m-commerce users of variant location. This article compares two methods of delivering transactional data associated with an organisation's locational attributes to m-commerce users: one method takes a straightforward, enumerative approach; the second method uses a proposed "location-aware" approach that avails itself of the locational attributes of both the m-commerce user and the organisational locations of user interest. A simulation-based methodology is employed to compare the two methods and evaluate the relative performance of the proposed location-aware method. Results suggest that the location-aware method has significant potential to increase the speed with which locational data is delivered to m-commerce users.
Effects of low-dose heavy ion irradiation on male germ cell adaptation and genetics

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The heavy ions with high linear energy transfer and high relative biological effectiveness are much more deleterious on the male germ cells, ones of the most radiosensitive cells of the body,than low-LET ionizing radiation such as X-ray or gamma-ray. The effects of low-dose heavy ion irradiation on male germ cell adaptation and genetics and the possible mechanism of this adaptation are summarized in our laboratory. Our results showed that the heavy ion irradiation significantly increased the frequencies of chromosomal aberrations in spermatogonia and spermato-cytes of mice, the low dose heavy ion irradiation could induce significant adaptative response on mouse testes and human sperm, and pre-exposure of mouse testes with low-dose heavy ion can markedly alleviate damage effects in-duced by subsequent high-dose irradiation. The increase of SOD activity and decrease of lipid peroxidation levels induced by low-dose ionizing radiation may be involved in this adaptative response mechanism. These studies may provide useful theoretical and clinical bases for radioprotection of reproductive potential and assessment of genetic risks for human exposed to heavy ions in radiotherapy and in outer space environment.
The Comparision of the Expression of Caveolin-1 Between Tumor Tissues and Tissues Around Tumor of Renal Cell Carcinoma

Field: Medicine (Health Sciences)

Objective To evaluate the relationship between caveolin-1 and renal cell carcinoma by examinating the expression of caveolin-1 in tumor tissues of renal cell carcinoma and renal tissues around tumor. Methods There were 16 tissue samples taken from operation.All of them,8 were tumor tissues and 8 were renal tissues around tumor. The expression of caveolin-1 mRNA in all the tissues were studied by the method of RT-PCR. Results As to the expression of caveolin-1, 4 were positive in 8 tumor tissues of renal cell carcinoma and 8 were all negative in renal tissues around tumor. Making stastical analysis by Fisher exact probabilities in 2×2 table(P0.05), the result was statistically significant. Conclusion The expression of caveolin-1 was obviously different between tumor tissues and renal tissues around tumor of renal cell carcinoma.There may be close relationship between them.
Sternocleidomastoid muscle activation following inspiratory muscle training in patients with chronic obstructive pulmonary disease: a randomized clinical trial

Field: Medicine (Health Sciences)

ABSTRACT This study aims to assess the effect of short-time low frequency inspiratory muscle trainer (Threshold IMT) on inspiratory muscle strength and electromyographic activity of the sternocleidomastoid (SCM) muscle in people with chronic obstructive pulmonary disease (COPD). People with COPD participating in a lung rehabilitation program were allocated to a control or inspiratory muscle training (IMT) group. The control group participated in the usual rehabilitation, whereas the other group received IMT (performed with a load of 50% maximal inspiratory pressure (MIP) adjusted weekly). Both interventions lasted for 2 months. Outcomes included electromyographic analysis of the SCM and MIP. In total, ten participants were allocated to each group. The IMT group presented an increase in absolute (p<0.001) and predicted (p<0.001) values of MIP and also in pre- and post-intervention variation between groups (p=0.003 and p=0.008, respectively). Such differences were not found in the control group. The SCM muscle activity decreased in the IMT post intragroup evaluation (p=0.008). IMT provided a reduction of the electromyographic activity of SCM in COPD patients, also increasing inspiratory muscle strength in the study participants.
GUIDELINES FOR PERMITTING OVERLOADS. PART 1. EFFECT OF OVERLOADED VEHICLES ON THE INDIANA HIGHWAY NETWORK. FINAL REPORT

Field: Engineering (Physical Sciences)

A study has been conducted at Purdue University to develop a procedure for permitting overloaded trucks in Indiana. This study was funded by the Indiana Department of Transportation and the Federal Highway Administration. As a part of this study a three-dimensional, dynamic finite element program (3D-DFEM) was used to analyze flexible and rigid pavements and develop load equivalency factors. Truck loads moving at different speeds were included in the analysis and a number of material models were used to represent the actual pavement materials behavior under moving loads. The 3D-DFEM was verified for flexible and rigid pavement analysis.
Local women’s coalitions: Critical actors and substantive representation in Spanish municipalities

Field: Social Sciences (Social Sciences)

The relationship between descriptive representation and substantive representation is an issue that has been widely discussed by women’s studies scholars. In general, it is assumed that there exists a positive relationship between the two, but the literature and empirical analysis show that substantive representation also depends on the action of other critical actors, such as gender agencies and the women’s social movement. Comparative research has shown the existence of a common pattern in post-industrial democracies: the development of women-friendly policies depends on the existence of coalitions between these critical actors. However, the analysis usually focuses on the national or regional level, and there is very little analysis at the local level, despite this being a political arena in which these processes can be developed. The aim of this article is to analyse the effect of coalitions of critical actors on the responsiveness to the demands of women’s groups in the case of Spanish municipalities using a representative survey. The objective, therefore, is to apply advances in the women’s substantive representation literature to the local level in Spain. Main results show that responsiveness is higher in municipalities where women’s coalitions exist.
Leiomyosarcoma Tumor Embolism Masquerading as Thrombus in Transit

Field: Medicine (Health Sciences)

BACKGROUND Tumor embolism is a rare neoplastic complication that occurs when there is intravenous invasion by a benign or malignant tumor. We present the case of an asymptomatic patient with an incidentally discovered leiomyosarcoma tumor emboli, which was initially misdiagnosed as "thrombus in transit." CASE REPORT The patient was a 58-year-old woman who was incidentally found on echocardiogram to have a large tubular mass within the inferior vena cava and right atrium. Although initially characterized as "thrombus in transit", this mobile right atrial mass was present without clinical, echocardiographic, or radiographic evidence of pulmonary embolism or increased pulmonary arterial impedance. Given that a thrombus in transit is nearly always associated with submassive or massive pulmonary emboli and their attendant right heart sequelae, these pertinent negative findings led us to seek an alternative diagnosis. After a trial of conservative management with anticoagulation and attempted removal of the mass with the AngioVac system, the patient ultimately underwent median sternotomy and surgical embolectomy on cardiopulmonary bypass to remove the mass, which was later identified on pathology as a leiomyosarcoma. CONCLUSIONS With rare exceptions, "thrombus in transit" is accompanied by large pulmonary emboli and the presence of increased pulmonary artery pressure and right heart strain. The absence of clinical, echocardiographic, or radiographic evidence of these hemodynamic sequelae should raise suspicion for an alternative diagnosis. Tumor embolism should be considered in the differential diagnosis of any patient with a history of malignancy who presents with evidence of intracardiac mass or embolism.
“Reinvention” of EPA research office takes shape

Field: Environmental Science (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT"Reinvention" of EPA research office takes shapeALAN NEWMANCite this: Environ. Sci. Technol. 1995, 29, 1, 16APublication Date (Print):January 1, 1995Publication History Published online30 May 2012Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/es00001a736https://doi.org/10.1021/es00001a736research-articleACS PublicationsRequest reuse permissionsArticle Views11Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Implementation of free basic education policy

Field: Social Sciences (Social Sciences)

This report focuses on the results of the 2005 survey. It is divided into five sections. Section one briefly discusses the non-cost barriers to education. It then provides an overview of user fees - the impact that user fees have on school enrollment, household contributions as a percentage of total education expenditure, household education expenditures as a percentage of household consumption, and the impact of user fees on poor households. Section two presents the results of the 2005 World Bank survey on user fees. Section three draws on the experiences of eight African and three Asian nations that have eliminated user fees, in order to highlight the successes and challenges of implementing such policies. Section four provides observations on the lessons learned. Section five concludes the report and makes recommendations.