jimnoneill/paper-to-field-training huggingface dataset:
Virtual machine migration techniques for managing time-varied workloads

Field: Computer Science (Physical Sciences)

This paper studies the virtual machine migration problem under dynamic traffic environment in data centers, while considering the tradeoff among resource utilization, energy consumption, and migration frequency. We use the service level agreement (SLA) soft threshold model to avoid frequent peak migrations at the migration trigger point. In the source virtual machine selection process, the maximum relevance is considered during the virtual machines selection method to improve resource coupling. In the destination server selection, the multi-resource relevance and matching method is used to solve the coupling problem of a single resource and the matching problem of a variety of resources. The simulation results show the proposed algorithm can improve the utilization rate of server resources to reduce power consumption and ensure system stability by reducing migration times. We also show that compared to existing techniques the algorithm used in this study can better adapt to dynamic changes of workloads.
The preparation of D‐glucaric acid by oxidation of molasses in packed beds

Field: Chemical Engineering (Physical Sciences)

Abstract An attempt has been made to prepare glucaric acid by oxidation of sugar beet molasses in packed beds. In the first part, a suitable oxidizing medium was sought. Experiments were performed in a cylindrical Pyrex‐glass reactor with air–molasses cocurrent downflow. Spherical glass and cylindrical vanadium pentoxide particles were used as an inert packing and catalyst respectively. The addition of catalyst, sodium nitrite, nitric and sulfuric acids to the medium resulted in an improvement in glucaric acid yield. The presence of nitric acid in the oxidizing medium and the use of vanadium pentoxide catalyst were the most effective factors as regards the yield. In the second part, the effects of temperature, molasses concentration, amount of catalyst and air flow rate on the yield were studied; each of these variables increased the yield. The use of a longer catalyst bed, however, resulted in a decrease in the yield. The highest rate of conversion of glucose to glucaric acid was 63.9% at optimum conditions. © 2001 Society of Chemical Industry
Localities, Class and Gender

Field: Social Sciences (Social Sciences)

Deindustrialization, households and politics the class and gender restructuring of the Lancaster economy, 1950-1980 comparable localities - some problems of method explaining peripheral change policy, planning, and peripheral development occupational stratification and gender theories of women, work and unemployment spatial and historical variations in women's unemployment and employment capitalist and patriarchal relations at work - Preston cotton weaving, 1890-1940 gender and local politics - struggles over welfare policies, 1918-1939.
Anti-inflammatory effect of lycopene rich paste extract in the presence of NSAID on carrageenan induced paw oedema

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Immense interest in nutraceuticals and their potential benefits has created the need to review the existing scientific information on their effect in preventing and managing inflammation that accompanies most chronic diseases. This study focuses on the basic mechanisms of inflammation and the potential of nutraceutical lycopene against the carrageenan induced oedema. The nutraceutical lycopene, when tested against carrageenan induced paw oedema showed significant anti-inflammatory activity in a dose dependent manner along with test drug. The nutraceutical at the dose of 5,50 and 100 mg in combination with test drug at 5 mg/kg b. wt exhibited appreciable results and decreases the % swelling from 94.45% to 68%, 45% and 25% respectively. At the same dosage level, the MDA was decreased to 4.88, 4.07 and 3.77nmol/mg protein from Carrageenan induced rats (7.99nmol/mg protein). In addition, nutraceuticals along with the test drug increases the glutathione levels from 3.33 to 5.76, 6.01 and 7.98μg GSH/mg protein at the concentration of 5, 50 and 100mg/kg b wt.
An Analysis of the Stereotypes of Preacher’s Kids and its Application on their Spouses

Field: Social Sciences (Social Sciences)

An Analysis of the Stereotypes of Preacher’s Kids and its Application on their Spouses By Tara J. Allman The purpose of this study is to discover the results of the effects of stereotypes and under what conditions certain stereotypes occur. The focus of this study is to examine stereotypes connected to the children of a Protestant minister and the spouses of those children. Ethnographic interviews and surveys show that the stereotype does exist in two distinct ways. Children of ministers are expected to either be rebellious hellions or they are expected to be perfect role models. The stereotypes affect the respondents more as children and teenagers than as adults unless as an adult the child still attends the same church as the minister parent. Adult children of ministers not in the same church do not experience the stereotype as they had as children. The inlaws of ministers do not experience the same stereotypes that their spouses have and in some cases, not at all.
Evaluation of safety and efficacy of Hylan G-F 20 (Synvisc-One®) in patients with knee osteoarthritis in clinical practice

Field: Medicine (Health Sciences)

Combined therapy of osteoarthritis (OA) includes intra-articular injections of hyaluronic acid. A prospective observational multicenter noncomparative study was conducted in compliance with routine clinical practice in patients with knee OA IIII stages in order to assess 1-year long-term safety and efficacy of Hylan G-F 20 (Synvisc-One, one injection of 6 mL). Patients came for observation at 3, 6, and 12 months after intra-articular injection of Hylan G-F 20. The primary objective of the study was evaluation of pain severity while walking and rest by using the WOMAC VA3.1 (Western Ontario and McMaster Universities Osteoarthritis Index) scale after 26 and 52 weeks compared to baseline. Quality of life was measured by EQ-5D (EuroQuality of Lifefive dimensions); patients general condition was measured by PTGA (Patient Global Assessment) and COGA (Clinical Observer Global Assessment). Results of the study were based on data of 121 patients (79.51% women, 21.49% men), mean age 62.97 12.47 years. Positive clinical response was observed in 12 months (52 weeks) after Hylan GF-20 administration: pain severity versus baseline was decreased by 48.92% (p 0.001) as per WOMAC A, stiffness in the joints versus baseline by 49.72% (p 0.001) as per WOMAC B, difficulties in the daily life versus baseline by 41.54% (p 0.001) as per WOMAC C. Seven adverse events were detected in five patients (4%), and one serious adverse event (cardiovascular abnormalities) was noticed during the entire study that was unrelated to the study drug. The extent of clinical response did not correlate with the stage of osteoarthritis. The quality of life was improved by 35.28% (p 0.001) according to the questionnaire EQ-5D. The general condition of the patients was improved by 37.50% (p 0.001) as per COGA and 42,86% (p 0.001) as per PTGA. No patients were discontinued the study due to adverse event or any other reasons. Intra-articular injections of Hylan G-F 20 6 mL were associated with acceptable safety and efficacy, and the therapeutic effect was observed up to 52 weeks.
Acoustic Measurements of Wasp (Vespa simillima xanthoptera Cameron) and Honey Bees with their Frequency Characteristics

Field: Agricultural and Biological Sciences (Life Sciences)

Vespid wasps (Vespa spp.) are the most noxious pests on apiculture, resulting in significant economic losses. Early monitoring and management are the first step to prevent the damages from vespid wasps. In this study, the acoustic signals from wasps and honey bees were measured by a microphone with a preamplifier and an analog-digital converter. In frequency analysis of the acoustic signals from wasps and honey bees, there were differences between the two species. While the fundamental frequency of the wasps was analyzed to be about 100 Hz with the strong harmonic frequencies, that of the honey bees was about 200~250 Hz. The 2SUPnd/SUP harmonic signals from wasp were strongest while the fundamental ones from honey bees were. These different sound features generated by wasps or honey bees might be applied to develop the early monitoring system of the incursion of wasps to the apiary.
Astro-Politics: US-India Strategic Cooperation in Space and its Implications for China (2000-2024)

Field: Social Sciences (Social Sciences)

The Article aims to investigate the strategic purpose of space as a new battlefield among the great powers of the 21st century. The US sees China as its great adversary in space hence its cooperation with India for strategic purposes to engage China which is posing a national security threat to China. Similarly, increasing Indian space capabilities is also misbalancing the pendulum of power in South Asia. The offensive and defensive approaches from the broader framework of Neo-Realism have been employed to interpret the whole power competition. Qualitative research methodology grounded in post-positivism has been employed. Data would be gathered through the help of primary & secondary sources and document study would also be utilized for data analysis. The findings of the study are expected to show that an arms race in space can cause space warfare among major global powers.
Divergent and Convergent Thinking across the Schoolyears: A Dynamic Perspective on Creativity Development

Field: Psychology (Social Sciences)

ABSTRACT Creative thinking is critical to overcome many daily life situations. As such, there has been a growing interest on how creative thinking develops during childhood. However, little is known about the underlying mechanisms driving its development. Indeed, almost all research has focused on divergent thinking, leaving aside convergent thinking, and did not thoroughly investigate how internal and/or external factors influence their development. Here, 222 children aged from 4 to 12 years old attending either a Montessori or a traditional school performed drawing‐based convergent and divergent standardized tasks. In addition, a subset of 41 children were tested using similar tasks for a second session 3 years apart. The results revealed dynamic developmental stages of convergent and divergent thinking. More specifically, a loss of divergent thinking was counterbalanced by a gain of convergent thinking, especially during the fourth‐grade slump (8–10 years old). Although Montessori‐schooled children showed overall higher creative abilities than traditionally schooled children, no differences were observed in the developmental trajectories of convergent and divergent thinking between the two pedagogies. This suggests that progress and decrease in creative thinking may be mostly due to internal factors such as brain maturation factors than external factors such as peer pressure.
Trends in the Surgical Treatment of Pseudotumor Cerebri Syndrome in the United States

Field: Medicine (Health Sciences)

This study's findings suggest that shunting is more common than ONSF and that the use gap has widened as shunting has increased. However, because overall PTCS-related hospitalizations have increased even more rapidly, the percentage of inpatients with PTCS undergoing surgery has decreased. These trends may reflect changes in medical treatment practices and outcomes or growing limitations in access to ophthalmic surgical expertise.
Valproic acid Promotes the in Vitro Differentiation of Human Pluripotent Stem Cells Into Spermatogonial Stem Cell-like Cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Background: Studying human germ cell development and male infertility is heavily relied on mouse models. In vitro differentiation of human pluripotent stem cells into spermatogonial stem cell-like cells (SSCLCs) can be used as a model to study human germ cells and infertility. The current study aimed to develop the SSCLC induction protocol and assess the effects of the developed protocol on the SSCLC induction. Methods: We examined the effects of valproic acid (VPA), vitamin C (VC) and the combination of VPA and VC on the SSCLC induction efficiency and determined the expression of spermatogonial genes of differentiated cells. The percentage of haploid cells and cells expressed meiotic and spermatid genes were also detected. RNA-sequencing analysis was performed to compare the transcriptome between cells at 0 and 12 days of differentiation and differently expressed genes were confirmed by RT-qPCR. We further evaluated the alteration in histone marks (H3K9ac and H3K27me3) at 12 days of differentiation. Moreover, the SSCLC induction efficiency of two hiPSC lines of non-obstructive azoospermia (NOA) patients was assessed using different induction protocols. Results: The combination of low concentrations of VPA and VC in the induction medium was most effective to induce SSCLCs expressing several spermatogonial genes from human pluripotent stem cells at 12 days of differentiation. High concentration of VPA was more effective to induce cells expressing meiotic genes and haploid cells. RNA-sequencing analysis revealed that the induction of SSCLC involved the upregulated genes in Wnt signaling pathway, and cells at 12 days of differentiation showed increased H3K9ac and decreased H3K27me3. Additionally, two hiPSC lines of NOA patients showed low SSCLC induction efficiency and the expression of genes in Wnt signaling pathway. Conclusions: VPA robustly promotes the differentiation of human pluripotent stem cell lines into SSCLCs, which involved the upregulated genes in Wnt signaling pathway and epigenetic changes. hiPSCs from NOA patients showed decreased SSCLC induction efficiency and Wnt signaling pathway gene expression, suggesting that inactivation of Wnt signaling pathway might be a cause of SSC depletion in azoospermia testes. Our developed SSCLC induction protocol provides a reliable tool and model to study human germ cell development and male infertility.
Role of carbohydrates in cell membrane receptors for vesicular stomatitis virus.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

A study has been made to clarify the importance of some carbohydrate components of goose red blood cell and BHK 21 cell membrane receptors for vesicular stomatitis virus (VSV). Experiments have been carried out by inducing enzymatic modifications on the surface of intact cells and following the interaction between VSV and treated cells. Results obtained indicate that the removal of mannose, galactose and fucose from cell membranes reduces the attachment of the virus to cell receptors.
Pandemic Fear and Weight Gain: Effects on Overweight and Obese Adults’ Purchasing Exercise Apparel Online

Field: Psychology (Social Sciences)

The purpose of this study was to investigate the interactive effect of pandemic fear and weight gain on overweight and obese consumers’ decisions to purchase exercise apparel online based on the theory of planned behavior and body-related self-discrepancy theory. A sample of 515 male and female adults with BMIs of 25 and higher participated in this study. The effect of pandemic fear on the attitudes toward purchasing exercise apparel online was only positive for overweight and obese consumers who did not gain weight during pandemic. However, for those who gained weight during the pandemic, there was no significant effect of pandemic fear on the attitudes toward purchasing exercise apparel online. Attitudes, subjective norm, and perceived behavioral control were all significant predictors of intent to purchase exercise apparel online. This study extends the theory of planned behavior by adding the pandemic-related factors and provides practical implications for online retailers.
Molecular dissection of anti-colon cancer activity of NARI-29: special focus on H2O2 modulated NF-κB and death receptor signaling

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Accumulating evidence attributes the role of aldose reductase (AR) in modulating ROS and inflammation which are the main factor responsible for cancer progression and drug resistance. Epalrestat is the only AR inhibitor being used in Asian countries. It did not make it to the markets of the USA and Europe due to marginal efficacy as an antioxidant and anti-inflammatory agent owing to difficulty reaching intracellular targets. In our previous studies, we attempted to synthesize the epalrestat analogs and reported that the compound 4-((Z)-5-((Z)-2-Cyano-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl) benzoic acid named as NARI-29 has potent AR inhibition compared to epalrestat. In the current study, we aimed to find the effect of NARI-29 on ROS-induced cancer progression and TRAIL resistance in colon cancer in vitro models. In the first part of the study, we demonstrated that the NARI-29 has specific AKR1B1 inhibition and superior drug-like properties than epalrestat using bioinformatics tools. In the second part of the study, it was proven that NARI-29 has induced the hydrogen peroxide-triggered TRAIL-induced apoptosis in the colon cancer cells via modulating the AKR1B1/4HNE/FOXO3a/DR axis. The selective cytotoxicity of NARI-29 (10-fold) compared to epalrestat (4-fold) toward cancer cells is due to its differential ROS regulation and anti-inflammatory activities. Altogether, these data show that NARI-29 may be a potential candidate for AR inhibitors, which will be used to prevent colon cancer progression and as adjuvant therapy for preventing TRAIL resistance. AKR1B1 is over-expressed in advanced-stage human colon cancer tissues AKR1B1 mediates resistance to H2O2 and TRAIL in human CRC cell lines A co-activation loop exists between NF-κB and AKR1B1 in CRC cell lines to counteract ROS Establishing epalrestat analog, NARI-29 (4-((Z)-5-((Z)-2-Cyano-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl) benzoic acid) as potent anti-colon cancer agents NARI-29 induced selective apoptosis in colon cancer cells by differentially modulating the ROS and sensitizing TRAIL
Glucosinolate Content and Sensory Evaluation of Baby Leaf Rapeseed from Annual and Biennial White‐ and Yellow‐Flowering Cultivars with Repeated Harvesting in Two Seasons

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract The chemical and sensory quality of field‐grown vegetables may be influenced by cultivar choice and agronomic factors but knowledge is lacking on the new rapeseed vegetables. White‐ and yellow‐flowering rapeseed cultivars were tested in two seasonally different field studies in Denmark at three different growing stages by early sowing the first year and late sowing the second year. Content of glucosinolates (GLSs) was analyzed, and the sensory quality of baby leaf samples was evaluated. The GLS content differed among cultivars across years in all growing stages, with biennial cultivars having the highest GLS content. In the second year, a higher content of all identified GLSs was found at two growing stages except for neoglucobrassicin and gluconasturtiin, compared to the first year. On the contrary, higher contents of all identified GLSs were found at a third stage in the first year except for progoitrin and 4‐methoxy glucobrassicin. Sensory evaluation of bitterness revealed differences among cultivars, higher intensities of bitterness in biennial cultivars, and a relationship between bitterness and content of bitter‐tasting and total GLSs. The effect of repeated harvesting on GLS content differed between the years and no general pattern was seen, except that the composition of individual GLSs was comparable for the biennial cultivars. We conclude that growing season and life cycle had a stronger influence on GLS content than stage at harvest. The link between bitter‐tasting GLSs and bitterness revealed that life cycle and seasonal effects affected the sensory profile of baby leaf rapeseed thereby making a healthier product due to high content of health‐beneficial GLSs.
Assessing Disease Outcome in COVID-19 Pregnancies in a Tertiary Referral Center in South India: A Single-center Retrospective Cohort Study

Field: Medicine (Health Sciences)

ABSTRACT Aim To study the outcome in COVID-19-positive pregnancies. Materials and methods Data collected and analyzed retrospectively from COVID-19-positive pregnant women admitted to our hospital between April and September 2020. Results 78.85% of women below 30 years of age, 60.57% multigravidae, 53.71% above 37 weeks of gestation. 76.85% no comorbidities, 73.42% no history of travel/contact with COVID-19 cases. 84.57% asymptomatic, two had a severe acute respiratory infection (SARI), requiring intensive care. 74.57% diagnosed using reverse transcriptase-polymerase chain reaction (RT-PCR). 91.42% turned negative within 6–10 days. The SARI patients required intensive care unit (ICU) care, one expired. 81.42% discharged between 8 days and 14 days of admission, returned for delivery at term. 83.42% required no medication. 96.28% had normal investigation reports. 83.14% of patients discharged, 16.57% required emergency obstetric intervention. Cesarean section rate 52.28%, the previous cesarean section most common indication (43.16%). Two babies were stillborn. 99.20%, Apgar > 7 at 5 minutes. Two required resuscitations. Nine required neonatal intensive care unit (NICU) admission. Two hundred and seven babies isolated from their mother, four turned positive. Forty-four were roomed in with mothers, 30 turned positive. One hundred and sixty-seven were breastfed, included 34 positive babies. Affected babies were asymptomatic. Conclusion COVID-19 runs a milder course in pregnancy, possibly due to altered immune status. However, severe cases can deteriorate rapidly. There is evidence of community spread. COVID-19 seemed to increase cesarean rates. Neonatal transmission appeared higher following vaginal deliveries, rooming-in, and breastfeeding. Clinical significance There is a dearth of adequate data to formulate guidelines about COVID-19-positive pregnancies despite numerous studies. We hope that our findings make a humble addition to ongoing research and provide further impetus to the global fight against this pandemic. How to cite this article Nambiar SS, S Ajith, VP Reshmi. Assessing Disease Outcome in COVID-19 Pregnancies in a Tertiary Referral Center in South India: A Single-center Retrospective Cohort Study. J South Asian Feder Obst Gynae 2020;12(5):335–339.
Unraveling Memory Representations: Interactive Effects of Visual and Conceptual Feature Representations on Memory Decisions

Field: Neuroscience (Life Sciences)

In daily life, we rely on memory to make accurate decisions, such as distinguishing the correct highway exit from similar-looking alternatives. While memories store enough features for such discriminations, how these features influence memory decisions remains unclear. The present study examines the impact of visual and conceptual representations on memory-based decisions. Experiment 1 (N=140) revealed that both types of representations influence the decision process, but only conceptual representations led to memory errors. Experiment 2 (N=253) showed that while subjects are more prone to errors when competing stimuli are conceptually similar, this effect is diminished when such competitors are also visually similar. Experiment 3 (N=315) additionally showed that both types of representations influenced confidence judgments by increasing the feeling of recollecting specific details of the memory. Taken together, our results show that memory-based decisions rely on multiple and interactive stimulus representations.