jimnoneill/paper-to-field-training huggingface dataset:
Can severe language disability be identified in three‐year‐olds? Evaluation of a routine screening procedure

Field: Health Professions (Health Sciences)

This study evaluates the predictability of a new language screening procedure in 3‐y‐olds. It is used in several Child Health Centres (CHC) in Sweden and has the character of a field study involving more than 60 CHC nurses. The main questions concern the (i) development in 3‐y‐olds assessed as severely language delayed and (ii) whether there are any earlier unknown severely disabled children identified at 4 y of age. Ninety‐six percent of the original study population participated in the follow‐up. The calculations are based on results from 2237 children. A well‐established screening routine, which has been shown capable of predicting the risk of not being able to follow expected schooling, and case records were used as an acceptable proxy outcome measure, pending a better gold standard. In the group of severely disabled 3‐y‐olds, sensitivity, specificity and positive predictive values were 86, 99 and 43%, respectively. Finally, three false‐negatives were identified. In light of the present results, continued application of the 3‐y screening is discussed.
Maternal Supplementation with Antioxidant Vitamins in Sheep Results in Increased Transfer to the Fetus and Improvement of Fetal Antioxidant Status and Development

Field: Veterinary (Health Sciences)

Twinning and maternal nutritional restriction leads to fetal hypoxia, oxidative stress, and intrauterine growth restriction (IUGR) in near-term sheep pregnancies. Our aim was to determine the effect of oral supplementation of vitamins C and E in pregnant sheep on maternal and umbilical cord blood concentrations of vitamins C and E and the effects on fetal antioxidant status, growth, and placental efficiency. Sixteen single- and sixteen twin-bearing ewes, grazing natural Patagonian prairies, were selected after transrectal ultrasound at day 30 after mating. Half of ewes from each pregnancy rank were supplemented daily with vitamins C and E, administered orally, from 30 to 140 days of gestation, when maternal jugular and fetal venous cord blood samples were obtained during cesarean section. Fetuses were weighed and sexed. Placental weight in each fetus was also obtained. Blood plasma was harvested for measurements of maternal and fetal vitamins concentration and fetal antioxidant capacity. Maternal administration of vitamin C and E was associated with increased fetal cord levels of both vitamins, improved antioxidant status, and enhanced fetal growth in both singleton and twin pregnancies associated with increased placental efficiency. These results highlight the potential of vitamin C and E supplementation to reduce the impact of IUGR in both livestock and humans.
Building consensus of Human Papillomavirus using Genetic Algorithm

Field: Computer Science (Physical Sciences)

The paper introduces a novel three tier architecture to find consensus of Human Papillomavirus (HPV). The proposed procedure is based on simulation and uses all complete genomic DNA sequences of registered HPV strains available in NCBI GenBank. It uses the multiple sequence alignment tool Clustal X to align these sequences. Genetic Algorithm is used to evolve an optimized population of complete genomic DNA sequences. The GA, which uses domain specific genetic operators like migration, rank selection, mutation and crossover, adopts a novel approach in defining the fitness function. A modified approach of the Weight Matrix Algorithm is applied on the optimized and evolved population to find a consensus of HPV. The effectiveness of the procedure is validated with experimental results.
P44 Embedding public involvement in research prioritisation for public health research in local councils: lessons from NIHR health determinants research collaboration Medway

Field: Health Professions (Health Sciences)

Background: NIHR Health Determinants Research Collabora tions, led by local government, are at the forefront of ree sarch to tackle the wider determinants of health in the UK. We report on how NIHR HDRC Medway has addressed one of the key challenges for HDRCS: establishing mechanisms by which the public voice can be involved in prioritising research questions in these novel Local Authority settings. Specifically, we aimed to develop an equitable, transparent and responsive system for research prioritisation that supports local residents to contribute ideas for research prioritisation, as well as to contribute to development and review of the research prioriti sation system. Methods: We established a research prioritisation working group (RPWG) comprising members of our Public Advisory Group (PAG) and executive team. We worked as a RPWG to co-design criteria for use with the Analytic Hierarchy Process (AHP) that determines scores for proposed research questions, and to co-design the broader system supporting local residents to submit those research questions. Results: Two PAG members elected to join the RPWG. The initial list of nine criteria identified by informal literature review was reduced to three criteria by the RPWG. A Priority Setting Partnership (PSP) was established to review these crite ria further, to use pairwise comparisons to develop a scoring system reflecting their relative importance (the AHP) and to annually review how those scores are applied to incoming research questions. To further embed the public voice, it was decided that of the 20 PSP members, four to five should be Medway residents and a further three should be members of Medway charities or not-for-profit organisations. Discussion: A co-design approach to developing and delivering a responsive research prioritisation process is tractable and meets HDRC remit in addressing wider determinants of health of relevance to local communities without needing to limit the prioritisation to certain health issues. The use of AHP (to pro vide a transparent and equitable means of prioritisation) was decided before the RPWG was formed and initial draft criteria were identified by informal literature review without lay input. Annual evaluation of our process may identify limitations to our research prioritisation process. Our next step is to co design the process by which members of the public – includ ing those from under-served communities - can submit research ideas. Our experience suggests that embedding public voice in process development in other areas of population health research is likely to be fruitful.
Sleep Quality Among U.S. Military Veterans With PTSD: A Factor Analysis and Structural Model of Symptoms

Field: Psychology (Social Sciences)

Poor sleep quality among individuals with posttraumatic stress disorder (PTSD) is associated with poorer prognosis and outcomes. The factor structure of the most commonly employed measure of self‐reported sleep quality, the Pittsburgh Sleep Quality Index (PSQI), has yet to be evaluated among individuals with PTSD. The current study sought to fill this gap among a sample of 226 U.S. military veterans with PTSD (90% with co‐occurring mood disorders, 73.5% with substance use disorders). We evaluated the factor structure of the PSQI by conducting an exploratory factor analysis (EFA) in approximately half of the sample ( n = 111). We then conducted a second EFA in the other split half ( n = 115). Lastly, we conducted a path analysis to investigate the relations between sleep factors and PTSD symptom severity, after accounting for the relation with depression. Results suggested sleep quality can best be conceptualized, among those with PTSD, as a multidimensional construct consisting of 2 factors, Perceived Sleep Quality and Efficiency/Duration. After accounting for the association between both factors and depression, only the Perceived Sleep Quality factor was associated with PTSD (β = .51). The results provide a recommended structure that improves precision in measuring sleep quality among veterans with PTSD.
Evaluation of adsorption capacity of single-walled carbon nanotubes for application to micro gas preconcentrators

Field: Engineering (Physical Sciences)

A micro gas preconcentrator which has a single walled carbon nanotube (SWNT) film as a sorbent material was fabricated by MEMS technology. This work is the first to investigate the performance of SWNTs in the preconcentrator by evaluating their adsorption capacity. Octane adsorption experiments were carried out for 60 minutes on the newly fabricated preconcentrator and the concentration factor was found to reach 86,000.
Abstract 1226: SETD2 loss in renal epithelial cells induces epithelial to mesenchymal transition in a TGFβ-independent manner

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC) and accounts for majority of the deaths from renal cancer. SETD2, the sole histone methyltransferase that catalyzes trimethylation of lysine 36 on histone H3 (H3K36me3), is frequently mutated in ccRCC. Studies have shown that SETD2 mutations are often subclonal and the mutation rate dramatically increases from 25% in primary ccRCC to more than 60% in metastatic ccRCC, suggesting SETD2 loss plays an important role in renal cancer metastasis. However, mechanisms underpinning how SETD2 mutation drives invasion and metastasis in ccRCC is largely unknown. Here, by performing RNA-seq and ATAC-seq in a non-tumorigenic renal epithelial cell line isogenic for SETD2 loss-of-function, we found that SETD2 inactivation induces dramatic changes in the transcriptome and drastically enhances chromatin accessibility, which allows binding of a variety of transcription factors. We also discovered that SETD2 loss induces a TGFβ-independent EMT program, which is a major pathway linked to metastasis. Correlation of RNA-seq with ATAC-seq identifies SOX2, OCT2 and PRRX1 as key transcription factors promoting the SETD2 loss-driven EMT program. Furthermore, we found that this distinct EMT program is in part triggered by secreted factors, which suggests that SETD2 mutation promotes a metastasis-permissive tumor microenvironment through paracrine signaling. In summary, our findings reveal that SETD2 is a key regulator of EMT phenotypes that may explain the role of SETD2 mutations in ccRCC metastasis and further uncover potential therapeutic targets for SETD2-mutant ccRCC patients. Citation Format: Tianchu Wang, Ryan Wagner, Ryan Hlady, Sungho Kim, Xiaoyu Pan, Thai Ho, Keith Robertson. SETD2 loss in renal epithelial cells induces epithelial to mesenchymal transition in a TGFβ-independent manner [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1226.
33., New Occurrence of Rotaliatina in the Pliocene of Java

Field: Earth and Planetary Sciences (Physical Sciences)

Rotaliatina屬の地質的分布は, 從来Mexico州のCarrizoの上部始新期のみと限られて居たが, 今囘Javaの上部鮮新期と考へられてゐる砂岩中により, 本屬の一新種(Rotaliatina globosa n., sp.,を發見したことにより, 地質的分布に變革を要することになつた。茲に興味あることは, アメリカの始新期有孔蟲の或者が, 現在のIndo-pacificの有孔蟲類と甚だ密接な關係にあることが, CUSHMAN氏の研究に依り明かにされた所であるが, 本新種の發見に依り, 一層其感を深くする。〓ほ, REUSS氏のRotalina bulimoides REUSS, 1851はRotaliatinaに屬するものと考へられ, 欺くすれば, 本屬の地質的分布はUpp., Eocene (Carrizo, Mexico) - Miocene (Hermsdorf, near Berlin) - Pliocene (Bodjong, Bantam Java)となる。最後に, 資料を提供された地質調査所の千谷, 渡瀬の兩氏並に, ジャバ石油組合の方々に厚く感謝の意を表す。
Efficacy of SC and SR intervention (Nowell et al., 2019)

Field: Psychology (Social Sciences)

Purpose: This study aimed to examine the initial efficacy of a parent-assisted blended intervention combining components of Structured TEACCHing and Social Thinking, designed to increase social communication and self-regulation concept knowledge in 1st and 2nd graders (n = 17) diagnosed with autism spectrum disorder (ASD) and their parents.Method: A randomized delayed treatment control group design with pre- and postintervention assessments of both parents and children was implemented within a community practice setting. Two follow-up assessments at 3 and 6 months postintervention were also completed.Results: Overall, results indicate that the intervention is efficacious in teaching social communication and self-regulation concept knowledge to children with ASD and their parents. Both parents and children demonstrated an increase in social communication and self-regulation knowledge after participating in the Growing, Learning, and Living With Autism Group as compared to a delayed treatment control group. The effects of the intervention did not extend to parent–child interactions coded from video recordings. Child treatment effects were maintained at the 3- and 6-month follow-up assessments.Conclusions: Preliminary efficacy of the Growing, Learning, and Living With Autism Group was established. Based on parent report at the conclusion of the intervention, this is a socially valid intervention for teaching social communication and self-regulation skills to school-age children with ASD.
Supplemental Material S1. The Growing Living and Learning with Autism (GoriLLA) Child Observation Protocol (COP).
Supplemental Material S2. The Gorilla Group Parent Report of Group Outcomes (PROGO).
Supplemental Material S3. GoriLLA Group treatment fidelity sample.
Supplemental Material S4. GoriLLA Group clinician quality and behavior management fidelity ratings.
Nowell, S. W., Watson, L. R., Boyd, B., & Klinger, L. G. (2019). Efficacy study of a social communication and self-regulation intervention for school-age children with autism spectrum disorder: A randomized controlled trial. Language, Speech, and Hearing Services in Schools, 50, 416–433. https://doi.org/10.1044/2019_LSHSS-18-0093
The Impact of Changing Family Structures on the Income Distribution among Costa Rican Women 1993–2009

Field: Economics, Econometrics and Finance (Social Sciences)

Changes in family structures, such as the composition of households with respect to size, age, and gender, can have an impact on poverty rates and the income distribution more generally. This study analyzes the impact of changing family structures on the income distribution among adult Costa Rican women between 1993 and 2009, using decomposition methods. There was a general increase in the share of family structures associated with lower incomes (singles with dependents) until 2001. After 2001, this trend reversed for women at the upper end of the income distribution, while it continued for women at the lower end. Correspondingly, this study finds a general negative effect of changing family structures on incomes of adult women until 2001, and an inequality-increasing effect after 2001. The change in trends might be due to a law coming into force in 2001 that mandated DNA tests for presumptive fathers unwilling to recognize their children.
WPMP façade detail type 1

Field: Arts and Humanities (Social Sciences)

Realized within the project of the sourced-based reconstruction of the New Synagogue in Wroclaw/Breslau (Poland). Link to the 3D model documentation: http://www.vfu-oppler.hs-mainz.de/en/wisski/navigate/679/view. Supported by »The German Federal Government Commissioner for Culture and the Media « (02/2018-11/2019) and »The Foundation for Polish-German Cooperation« (05/2018). Magnified by https://architekturinstitut.hs-mainz.de/. Published under CC-BY-NC-SA 4.0. Source: Objaverse 1.0 / Sketchfab
A Unified Approach for Processing Unbalanced Conditions in Transient Stability Calculations

Field: Engineering (Physical Sciences)

A unified approach has been proposed in the paper for processing unbalanced operating conditions in transient stability calculations. The suggested method combined advantages of both abc phase coordinates and 012 sequence coordinates. The former is used to describe faults since it is suitable to modeling simultaneous faults and the latter is used for time simulation for its sparse nature. Novel fault description and coordinate conversion formulation is presented. The equivalent positive sequence bus admittance matrix is derived for interface with generators in stability simulation. With the new method, the sequence network constitution can be avoided; multiple and simultaneous faults and element parameter unbalance can be simulated easily; and the sparse technology can still be applied for study efficiency. Computer test results show clearly the effectiveness and efficiency of the new method. © 2006 IEEE.
A numerical analysis of Quincke rotation

Field: Physics and Astronomy (Physical Sciences)

This paper deals with the Quincke rotation of small particles. It is usual to explain this DC electorotation looking at the action of the free charges present in the liquid which under the application of an electric field accumulate at the surface of the insulating object. Then it acquires a dipole moment in the direction opposite to that of the field. In turn the particle begins to rotate in order to flip its dipole moment. We present a numerical study of the rotation of and infinite cylinder whose axis is perpendicular the DC E field. Using a finite element method, we solve the conservation equations for the positive and the negative ions coupled with the Stokes equation. Doing so, we determine the charge distribution around the rotating particle and the fluid velocity field. Then, we de duce the angular velocity of the cylinder and we show that, contrary to what is usually assumed, the spin rate of the rotor can depend on its size. This dependence is particularly significant for small rotor whose typical dimension is smaller than few microns.
The Future of Pharmacogenetics in the Treatment of Heart Failure

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Heart failure is a common disease with high levels of morbidity and mortality. Current treatment comprises β-blockers, ACE inhibitors, aldosterone antagonists and diuretics. Variation in clinical response seen in patients begs the question of whether there is a pharmacogenetic component yet to be identified. To date, the genes most studied involve the β-1, β-2, α-2 adrenergic receptors and the renin-angiotensin-aldosterone pathway, mainly focusing on SNPs. However results have been inconsistent. Genome-wide association studies and next-generation sequencing are seen as alternative approaches to discovering genetic variations influencing drug response. Hopefully future research will lay the foundations for genotype-led drug management in these patients with the ultimate aim of improving their clinical outcome.
The theory of decay in radioactive luminous compounds

Field: Physics and Astronomy (Physical Sciences)

It has been found that the luminosity of radium luminous compound at first rises rapidly to a maximum and then decreases, according to an exponential law, for about 200 days from manufacture. From this time on, however, the rate of luminosity decrease becomes slower and slower, so that the brightness tends to approach a limiting value which is not zero. The following paper is the .result of an attempt to find some explanation of this behaviour such as will furnish grounds for the prediction of the ultimate behaviour of compounds of varying composition. The theory of destruction of “active centres,” put forward by Rutherford to explain the fact of decay, leads to a simple exponential which, as has been said, represents the results to a sufficiently close approximation during the first part of the life, but fails increasingly at the later period.
Bio-efficacy and phyto-toxicity of post-emergence herbicides tank mixtures on soybean (Glycine max L. Merrill)

Field: Agricultural and Biological Sciences (Life Sciences)

The field experiment was replicated thrice in randomised complete block design at Main Agricutural Research Station, Dharwad during kharif 2018 to study the bio-effiacy and phyto-toxicity of post-emergence herbicides tank mixtures on soybean (Glycine max L. Merrill). Application of Imazethapyr 75 g ha-1 + Quizalofop-p-ethyl 37.50 g ha-1 (75% RD) recorded significantly lower weed density (6.67 and 8.67 m-2 at 40 and 60 DAS, respectively), total weed dry weight (1.90 and 2.73 g m-2 at 40 and 60 DAS, respectively), and weed index (11.98%) with significantly higher weed control efficiency (77.75 and 85.79% at 40 and 60 DAS, respectively) seed yield and net returns (2,554 kg ha-1, â‚¹ 59,111 ha-1, respectively) over Imazethapyr alone. It was at par with RWMP (2,652 kg ha-1, â‚¹ 62,111 ha-1, respectively) and Imazethapyr 75 g ha-1 + Propaquizafop ethyl 75 g ha-1 (2,356 kg ha-1, â‚¹ 50,791 ha-1, respectively). There was.broad spectrum weed control through herbicide tank mixtures compared to Imazethapyr alone. Phytotoxicity was not observed due to tank mixtures of herbicides.
A Case of Multiple Cranial Neuropathy Caused by Nasopharyngeal Necrosis Occurring Long after Radiotherapy

Field: Medicine (Health Sciences)

We report a case of multiple cranial neuropathy caused by nasopharyngeal necrosis occurring long after radiotherapy for nasopharyngeal carcinoma. The patient was a 63-year-old male with the chief complaint of headache. He had received chemoradiotherapy for nasopharyngeal carcinoma 27 years earlier and for paranasal sinus cancer 19 years earlier. Endoscopy revealed nasopharyngeal necrosis, and a contrast-enhanced CT of the neck revealed a low-density area across a wide region from the skull base to the nasopharynx. The patient was also found to have paralysis of the left glossopharyngeal nerve, right vagus nerve, left accessory nerve, and the hypoglossal nerves bilaterally. Although systemic administration of antimicrobial agents and steroids halted the progression of the necrosis, the cranial neuropathy remained. Treatment with appropriate radiation doses is necessary to mitigate the adverse events of radiotherapy, and adequate consideration must be given to radiation exposure, particularly in cases of relapse and cases such as this one, in which adjacent areas are also involved.
Analysis of rulings in former pretrial applications Chairman of the Corruption Eradication Commission (KPK)

Field: Social Sciences (Social Sciences)

<p>Pretrial in the Indonesian judicial system always raises<br />subjective views, therefore the decisions of many times of<br />misapplication of the law are included in the pretrial<br />application of the former chairman of the FB Corruption<br />Eradication Commission, which was later rejected by the<br />panel of judges on unprofessional grounds, but even<br />when the corruption case was suspected by the<br />Corruption Eradication Commission and allegedly filed a<br />pretrial even granted, that it can be perceived as if there<br />is such a grudge that the subjective view is used in an<br />unfair way, why is it so that pretrial petition. That the<br />pretrial filed by the FB applicant at the South Jakarta<br />Neferi Court not only pays attention to what is regulated<br />in the Criminal Code, Criminal Procedure Code but there<br />are laws above it, namely the 1945 Constitution, the<br />Judicial Power Law then the Criminal Code and the<br />Criminal Procedure Code, by looking at the hierarchy of<br />laws and regulations mentioned above, there will be no<br />legal process without going through the 1945<br />Constitution, therefore it refers to the 1945 Constitution.<br />Because it is regulated in article 27 of the 1945<br />Constitution, the law and its derivatives also regulate as<br />a manifestation of the 1945 Constitution, where in the<br />framework of Law of the Republic of Indonesia Number<br />27 of 1999 concerning Amendments to the Criminal Code<br />letter (a reads: that human rights are basic rights that are<br />inherently inherent in human beings, including the right<br />to obtain legal certainty and equality of position in the<br />country. in law, the rights of expression, association and<br />assembly based on Pancasila and the 1945 Constitution;</p>