jimnoneill/paper-to-field-training huggingface dataset:
Multicomponent self-assembled peptide hydrogels for biomedical cell culture applications

Field: Materials Science (Physical Sciences)

Biomimetic scaffolds have been an area of great interest in recent years for cell culture materials. Self-assembled peptide hydrogels are a type of biomimetic material that has excellent potential in this field owing to its ease of modification and unique physical characteristics. As many of nature’s peptides contain various biological motifs, it is easy to incorporate these motifs into a peptide gelator sequence. In addition, self-assembled peptide hydrogels are chemically well-defined, and the resulting fibrous networks are reversible due to the noncovalent interactions that mediate the self-assembly process. The encompassing aim of this Thesis is to monitor and control cell growth in and on multicomponent self-assembled peptide hydrogels. This was achieved by synthesising a small library of peptides containing biological motifs and using them in multicomponent systems to mimic the extracellular matrix which is a combination of many fibre types. The gels that were formed were characterised for the physical characteristics which revealed co-assembly and destructive interactions between different combinations of gels. A concentration study of the gelators also elucidated interesting concentration dependent traits. The hydrogels were also used in a series of in vitro experiments whereby factorial combinations (that is, all possible combinations of factors) were used to culture fibroblasts and human embryonic stem cells in 2D and 3D which revealed that cells not only survived, but on some surfaces were able to proliferate and attach. A novel chemiluminescent hydrogel was also synthesised to monitor oxidative stress in cells as an alternative to current assays to monitor cell behaviour. The gelator was shown to not only be able to respond to oxidative burst in T cells, but also be able to respond to the classic glucose oxidase and horse radish peroxidase reaction. This gel, therefore, holds good potential in multiple biomedical applications.
Foliage-roosting eastern red bats select for features associated with management in a central hardwood forest

Field: Agricultural and Biological Sciences (Life Sciences)

(Uploaded by Plazi for the Bat Literature Project) Forests provide crucial foraging and roosting habitat to many bat species, and the gradual loss of forests is among the principal threats to global bat diversity. Forests that persist in the face of land use change are those that are managed for a variety of uses, including recreation, hunting, timber production, and wildlife conservation. Thus, understanding how bats respond to management is imperative to their conservation. We used radio telemetry to study the roosting and foraging behaviors of male and female eastern red bats (Lasiurus borealis). These forestdependent bats roost in the foliage of live trees and are declining across their range. We tracked 26 bats (7 males and 18 females; one female was tracked twice) from May to August 2017–2019 in two state forests in south-central Indiana, USA. We estimated space use with 95% kernel density estimates and used generalized linear and linear mixed models to assess resource selection and use at three levels: population-level foraging selection, individual-level foraging use, and population-level roost selection. On average, eastern red bats foraged over a relatively small area (81 ha) and traveled a maximum distance of 1404 m from their roosts. The eastern red bat population foraged near maintained openings, recent regeneration openings, roads, and ponds within the study area. Within their foraging ranges, eastern red bats spent more time foraging near roads, ponds, and ridges. Eastern red bats roosted near maintained openings, recent regeneration openings, and ponds, switching roosts every two days. Roost trees were larger than random trees and were in plots containing fewer live stems than random plots. Together, these results reveal that some of the most important landscape features for eastern red bats are linear corridors (e.g., roads or ridgetops), forest openings (e.g., maintained openings and recent regeneration openings), perennial sources of water (e.g., ponds), and large trees. Overall, eastern red bats exhibited strong selection for managed portions of the forest, suggesting they can coexist with and likely benefit from timber management. When considering habitat for eastern red bats in central hardwood forests, we recommend land managers work to maintain large tracts of mature (>90 years old) forest, interspersed with young regeneration openings and provisioned with perennial water sources (e.g., ponds).
Dynamic Weighted Bar for Upper Limb Rehabilitation

Field: Health Professions (Health Sciences)

This paper explores the design of a dynamically weighted therapy bar, which can provide real-time quantitative performance information and adjustments during rehabilitation exercise. In contrast, typical therapy equipment is passive, offering no feedback to the patient or clinician. The dynamic weighted bar (DWB) was designed and fabricated containing an inertial sensor which tracks the orientation of the bar and adjusts the position of an internal weight accordingly, in turn providing a targeted force imbalance between the patient's two arms. Step input experiments were performed on the device while it was held in various stationary positions. The DWB was able to successfully function and transmit motion information. It was able to produce a center of mass shift of 101.6 mm, and a complete travel time between 0.96 s and 1.41 s over the entire length. The use of the DWB device can offer many benefits during rehabilitation including access to more quantitative information for clinicians as well as the potential for more personalized therapy programs.
Micafungin concentrations 100 mg daily in plasma and burn eschars in patients with severe burn injuries

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Micafungin (MCF) is an echinocandin agent with broad activity against Candida spp., which are frequently isolated in blood and eschar cultures of burned patients, who present different pharmacokinetics (PK) characteristics. Due to the limited information about its PK, we investigate MCF levels in plasma and burn eschar tissues in this population.
[Influence of dendrite cells, generated with the use of immunomodulators of microbial origin, on the proliferative and cytotoxic activity of lymphocytes].

Field: Immunology and Microbiology (Life Sciences)

The influence of ripe dendrite cells (DC) on the proliferative activity of mononuclear leukocytes and the cytotoxic activity of lymphocytes of syngenic mice was studied. As inducers of DC ripening, the combination of antigenic components incorporated into the vaccine "lmmunovac Bh-4", (Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli, Staphylococcus aureus), as well as K. pneumoniae LPS and TNF-alpha, were used. This study demonstrated that DC activated with these preparations enhanced the proliferative activity of mononuclear leukocytes, the activity of Bh-4 being higher than that of K. pneumoniae LPS. The increase of proliferative activity was accompanied by a rise in the cytotovicity of mouse lymphocytes with respect to the NK-sensitive tumor line YAC-1 or Ehrlich tumor cells. The incubation of the lymphocytes with ripe DC (with the use of the preparations under study as ripening inducers), loaded with tumor antigens, made it possible to obtain cytotoxic lymphocytes having high cytotoxic activity with respect, mainly, to those tumor lines from which lysates for the treatment of DC had been produced. The activation of DC with bacterial immunomodulators led to an increase in the antigen-presenting function of these cells, to their higher capacity for regulating the differentiation of mononuclear leukocytes and for activating the cytotoxicity of natural killers.
Nilpotent Singer Groups

Field: Mathematics (Physical Sciences)

Let $N$ be a nilpotent group normal in a group $G$. Suppose that $G$ acts transitively upon the points of a finite non-Desarguesian projective plane ${\cal P}$. We prove that, if ${\cal P}$ has square order, then $N$ must act semi-regularly on ${\cal P}$. In addition we prove that if a finite non-Desarguesian projective plane ${\cal P}$ admits more than one nilpotent group which is regular on the points of ${\cal P}$ then ${\cal P}$ has non-square order and the automorphism group of ${\cal P}$ has odd order.
Inventory Control 6. PERFORMING ORG. REPORT NUMBER

Field: Decision Sciences (Social Sciences)

Information and data contained In this document are based on input available at the time of proparation. Because the results may be subject to change. this document should not be constr!ued to represent the official position of 4 the US Army Material Comiand unless so stated. it. IKe WOaDS fCofitlav.neue Z iilt.o flecele.,p &amp;W lEdusUIv AW Wlk &quot;Wmbt) Negative binomial probability Inventory model £9Iiht.4 bv Cap-Paulson approximation NATIONAL TECHNICAL INFORMATION SER~VICE
Craniofacial Dysostosis With Syringomyelia and Associated Anomalies

Field: Medicine (Health Sciences)

A 16-year old boy had craniofacial dysostosis, hydrocephalus, and syringomyelia. Other anomalies included platybasia, a Klippel-Feil anomaly, webbed toes, and a cutaneous hemangioma. Evaluation included cerebral angiography, ventriculography, and myelography.
Characteristics and Survival Outcomes of Patients With Metastatic RET Fusion–Positive Solid Tumors Receiving Non-RET Inhibitor Standards of Care in a Real-World Setting

Field: Medicine (Health Sciences)

PURPOSE RET fusions are oncogenic drivers across different solid tumors. However, the genomic landscape and natural history of patients with RET fusion–positive solid tumors are not well known. We describe the clinical characteristics of RET tyrosine kinase inhibitor (TKI)-naïve patients with RET fusion–positive solid tumors (excluding non–small-cell lung cancer [NSCLC]), treated in a real-world setting and assess the prognostic effect of RET fusions. METHODS Data for RET TKI-naïve patients with metastatic solid tumors (excluding NSCLC) who had ≥one Foundation Medicine comprehensive genomic profiling test (January 1, 2011-March 31, 2022) were obtained from a deidentified nationwide (US-based) clinicogenomic database. The primary objective of this study was to compare the overall survival (OS) of patients with RET fusion–positive tumors versus matched patients with RET wild-type ( RET-WT) tumors. Patients with RET-WT solid tumors were matched (4:1) to patients with RET fusion–positive tumors on the basis of preselected covariates. RESULTS The study population included 26 patients in the RET fusion–positive cohort, 7,220 patients in the RET-WT cohort (before matching), and 104 patients in the matched RET-WT cohort. Co-occurring genomic alterations were rare in the RET fusion–positive cohort. Median OS was consistently lower in patients with RET fusion–positive tumors versus those with RET-WT tumors, using three different analyses (hazard ratios, 2.0, 1.7, and 2.2). CONCLUSION These data suggest that RET fusions represent a negative prognostic factor in patients with metastatic solid tumors and highlight the need for wider genomic testing and use of RET-specific TKIs that could improve patient outcomes. Our study also highlights the value of real-world data when studying rare cancers or cancers with rare genomic alterations.
Reputations on the line in Van Diemen’s Land: A dissertation on the general theme of the Rule of Law as it emerged in a young penal colony with particular emphasis on the law of defamation

Field: Social Sciences (Social Sciences)

This research focuses on the development of the jurisprudence of the infant colony of Van Diemen’s Land now known as Tasmania, with particular interest on the law of defamation. \nDuring the first thirty years of this British penal colony its population was subject to changes. There were the soldiery, who provided the basis of government headed by a Lieutenant Governor, the indigenous people, the convicts, and gradually an influx of settlers who came enthused by governmental promises of grants of land. In addition to these free settlers there were a selection of convicts who, under a process of something akin to manumission under Roman Law, became upon completion of their sentence, eligible for freedom and possibly a grant of land. \nThere developed a spirit of competition amongst the settlers, each wanted to become more successful than the others. The favourite means of distinguishing oneself was the uttering or publication of damaging words against a person who was perceived to be a rival. Various defamation actions between 1805 and 1835 are discussed, providing a fascinating insight into the emergence of a Rule of Law, however imperfect, in the development of the colonial society of Van Diemen’s Land.
How do we know what makes for “best practice” in clinical supervision for psychological therapists? A content analysis of supervisory models and approaches

Field: Psychology (Social Sciences)

Clinical supervision for psychotherapies is widely used in clinical and research contexts. Supervision is often assumed to ensure therapy adherence and positive client outcomes, but there is little empirical research to support this contention. Regardless, there are numerous supervision models, but it is not known how consistent their recommendations are. This review aimed to identify which aspects of supervision are consistent across models, and which are not. A content analysis of 52 models revealed 71 supervisory elements. Models focus more on supervisee learning and/or development (88.46%), but less on emotional aspects of work (61.54%) or managerial or ethical responsibilities (57.69%). Most models focused on the supervisee (94.23%) and supervisor (80.77%), rather than the client (48.08%) or monitoring client outcomes (13.46%). Finally, none of the models were clearly or adequately empirically based. Although we might expect clinical supervision to contribute to positive client outcomes, the existing models have limited client focus and are inconsistent. Therefore, it is not currently recommended that one should assume that the use of such models will ensure consistent clinician practice or positive therapeutic outcomes. Key Practitioner Messages There is little evidence for the effectiveness of supervision. There is a lack of consistency in supervision models. Services need to assess whether supervision is effective for practitioners and patients.
Fast Local Voltage Control Under Limited Reactive Power: Optimality and Stability Analysis

Field: Energy (Physical Sciences)

High penetration of distributed energy resources presents several challenges and opportunities for voltage regulation in power distribution systems. A local reactive power (VAR) control framework will be developed that can fast respond to voltage mismatch and address the robustness issues of (de-)centralized approaches against communication delays and noises. Using local bus voltage measurements, the proposed gradient-projection based schemes explicitly account for the VAR limit of every bus, and are proven convergent to a surrogate centralized problem with proper parameter choices. This optimality result quantifies the capability of local VAR control without requiring any real-time communications. The proposed framework and analysis generalize earlier results on the droop VAR control design, which may suffer from under-utilization of VAR resources in order to ensure stability. Numerical tests have demonstrated the validity of our analytical results and the effectiveness of proposed approaches implemented on realistic three-phase systems.
Performance of Different Carnation (Dianthus CaryophyllusL.) Cultivars Grown from Seed in the Plains of West Bengal, India

Field: Agricultural and Biological Sciences (Life Sciences)

The suitability of 6 spray carnation cultivars namely Chabaud Extra Mix, Enfont De Nice, Chabaud Mix, Chabaud Super Mix, Chabaud Finest Mix and Lilipot Mix grown from seeds were studied in the plains of West Bengal, India in this experiment. Plants of the variety Enfont De Nice was found longest (73.84 cm) and dwarfing nature was noticed with Lilipot Mix (47.38 cm). Highest numbers of side-shoots were recorded with Chabaud Extra Mix (18.12) and lowest with Enfont De Nice (12.80). Chabaud Mix produced highest number of leaves shoot−1 (21.38). Leaf length and leaf width were found highest with Enfont De Nice and lowest with Lilipot Mix. The plants of Lilipot Mix reached the Flower Bud Initiation (FBI) stage earliest (54.37 days) and the plants of Chabaud Extra Mix reached the FBI stage last of all (89.54 days). The shortest time period required for FBI to Colour Showing (CS) stage (34.75 days) was found with Chabaud Finest Mix. Cultivar Chabaud Mix required the most delayed time period to reach the full bloom stage (5.08 days) and Chabaud Finest Mix reached the full bloom stage earliest (4.00 days). Longevity of flower in-situ was recorded maximum with Lilipot Mix (7.29 days). Bud length and bud diameter was found highest with Chabaud Super Mix (4.25 cm and 67 cm respectively). Flower diameter was found highest with Chabaud Super Mix (5.91 cm) and lowest flower diameter was recorded with Lilipot Mix (4.56 cm). Chabaud Extra Mix was found the highly floriferous variety producing 47.38 flowers plant−1. Longest stalks were produced by Chabaud Super Mix (35.43 cm). Higher fresh weight of 100 flowers was noticed with Enfont De Nice (254.88 g). Maximum post-harvest longevity was recorded with Lilipot Mix (4.63 days). Lilipot Mix is found to be better as pot plant for its short stalk length, earlier blooming with maximum in-situ longevity of flowers. The other cultivars are suitable for loose and cut flower production. Chabaud Super Mix can be used for quality flower production but the recommended most floriferous variety is Chabaud Extra Mix.
Guidelines for Using Empirical Studies in Software Engineering Education.

Field: Computer Science (Physical Sciences)

Software engineering education is supposed to provide students with industry-relevant knowledge and skills. Educators must address issues beyond exercises and theories that can be directly rehearsed in small settings. A way to experience such effects and to increase the relevance of software engineering education is to apply empirical studies in teaching. In our article, we show how different types of empirical studies can be used for educational purposes in software engineering. We give examples illustrating how to utilize empirical studies, discuss challenges, and derive an initial guideline that supports teachers to include empirical studies in software engineering courses.
Dataset of "Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinityincreased CD8 T lymphocytes"

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Background: Affinity-optimized T cell receptor (TCR)-engineered lymphocytes targeting tumor antigens can mediate potent antitumor responses in cancer patients, but also bear substantial risks for off-target toxicities. Most preclinical studies have focused on T cell responses to antigen-specific stimulation. In contrast, little is known on the regulation of T cell responsiveness through continuous TCR triggering and consequent tonic signaling. Here, we addressed the question whether increasing the TCR affinity can lead to chronic interactions occurring directly between TCRs and MHC-(self) molecules, which may modulate the overall functional potency of tumor-redirected CD8 T cells. For this purpose, we developed two complementary human CD8 T cell models (i.e. HLA-A2 knock-in and knock-out) engineered with incremental-affinity TCRs to the HLA-A2/NY-ESO-1 tumor antigen.
Methods: The impact of HLA-A2 recognition, depending on TCR affinity, was assessed at the levels of the TCR/CD3 complex, regulatory receptors, and signaling, under steady-state conditions and in kinetic studies. The quality of
CD8 T cell responses was further evaluated by gene expression and multiplex cytokine profiling, as well as real-time quantitative cell killing, combined with co-culture assays.
Results: We found that HLA-A2 per se (in absence of cognate peptide) can trigger chronic activation followed by a tolerance-like state of tumor-redirected CD8 T cells with increased-affinity TCRs. HLA-A2pos but not HLA-A2neg T cells displayed an activation phenotype, associated with enhanced upregulation of c-CBL and multiple inhibitory receptors. T cell activation preceded TCR/CD3 downmodulation, impaired TCR signaling and functional
hyporesponsiveness. This stepwise activation-to-hyporesponsive state was dependent on TCR affinity and already detectable at the upper end of the physiological affinity range (KD ≤ 1 μM). Similar findings were made when
affinity-increased HLA-A2neg CD8 T cells were chronically exposed to HLA-A2pos-expressing target cells.
Conclusions: Our observations indicate that sustained interactions between affinity-increased TCR and self-MHC can directly adjust the functional potential of T cells, even in the absence of antigen-specific stimulation. The
observed tolerance-like state depends on TCR affinity and has therefore potential implications for the design of affinity-improved TCRs for adoptive T cell therapy, as several engineered TCRs currently used in clinical trials share
similar affinity properties.
Ultra-Widefield Laser Scanning Retina Imaging in Oculocutaneous Albinism

Field: Medicine (Health Sciences)

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