jimnoneill/paper-to-field-training huggingface dataset:
Design, Characterization, and Immune Augmentation of Docosahexaenoic Acid Nanovesicles as a Potential Delivery System for Recombinant HBsAg Protein

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Recombinant HBsAg-loaded docosahexaenoic acid nanovesicles were successfully developed, lyophilized (LRPDNV) and characterized for their physico-chemical properties. The zetapotential (ZP) of LRPDNV was −60.4 ± 10.4 mV, and its polydispersity (PDI) was 0.201, with a % PDI of 74.8. The particle sizes of LRPDNV were 361.4 ± 48.24 z. d.nm and 298.8 ± 13.4 r.nm. The % mass (r.nm) of LRPDNV in a colloidal injectable system was 50, its mobility value was −3.417 µm cm/Vs, while the conductivity of the particles was 0.728 (mS/cm). Transmission electron microscopic (TEM) analysis showed smooth morphological characteristics of discrete spherical LRPDNV. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) of LRPDNV revealed that LRPDNV is thermostable. The X-ray diffraction (XRD) studies showed a discrete crystalline structure of LRPDNV at 2θ. Nuclear magnet resonance (NMR) studies (1H-NMR and 13C-NMR spectrum showed the discrete structure of LRPDNV. The immunogenicity study was performed by antibody induction technique. The anti-HBs IgG levels were elevated in Wistar rats; the antibody induction was observed more in the product (LRPDNV) treatment group when compared to the standard vaccine group. The level of antibodies on the 14th and 30th day was 6.3 ± 0.78 U/mL and 9.24 ± 1.76 U/mL in the treatment and standard vaccine groups, respectively. Furthermore, the antibody level on the 30th day in the treatment group was 26.66 ± 0.77 U/mL, and in the standard vaccine group, the antibody level was 23.94 ± 1.62 U/mL. The LRPDNV vaccine delivery method released HBsAg sustainably from the 14th to the 30th day. The results of this study indicate the successful formulation of DHA nanovesicles which have great potential as an adjuvant system for the delivery of recombinant HBsAg protein.
Sri Lanka's Ethnic Conflict: The Indo-Lanka Peace Accord

Field: Social Sciences (Social Sciences)

Research Article| June 01 1988 Sri Lanka's Ethnic Conflict: The Indo-Lanka Peace Accord Ralph R. Premdas, Ralph R. Premdas Search for other works by this author on: This Site PubMed Google Scholar S. W. R. de A. Samarasinghe S. W. R. de A. Samarasinghe Search for other works by this author on: This Site PubMed Google Scholar Far Eastern Survey (1959) 28 (6): 676–690. https://doi.org/10.2307/2644660 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Ralph R. Premdas, S. W. R. de A. Samarasinghe; Sri Lanka's Ethnic Conflict: The Indo-Lanka Peace Accord. Far Eastern Survey 1 June 1959; 28 (6): 676–690. doi: https://doi.org/10.2307/2644660 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAsian Survey Search This content is only available via PDF. Copyright 1988 The Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.
IMMUNOSUPPRESSIVE TREATMENT OF IDIOPATHIC THROMBOCYTOPENIC PURPURA IN CHILDREN

Field: Medicine (Health Sciences)

ABSTRACT. Eleven children with symptomatic idiopathic thrombocytopenia were treated with immunosuppressive agents. Ten children received cyclophosphamide; I was given azathioprine. Only I child produced a full response, and 6 subsequently needed splenectomy which was curative. It is concluded that immunosuppressive treatment is ineffective in childhood thrombocytopenia and that splenectomy remains the treatment of choice for the rare case which fails to settle spontaneously or respond to corticosteroids.
Decision Management

Field: Decision Sciences (Social Sciences)

This article reviews the generic meaning of ‘system’ and complements more conventional system notions with a system perception based on recent complexity theory. With system as the core concept of systems theory, its actual meaning is not just of theoretical interest but is highly relevant also for systems practice. It is argued that complexity theory and thinking with reference to Luhmann a.o. ought to be recognised and paid attention to by the systems community. Overall, it is found that a complexity orientation may contribute to extend and enrich the explanatory power of current systems theory when used to complex real-world problems. As regards systems practice it is found that selective use and combination of five presented research approaches (functionalist, interpretive, emancipatory, postmodern and complexity) which function as different but complementing ‘epistemic lenses’ in a process described as constructive circularity, may strengthen the exploration and learning efforts in systems-based intervention.
STUDY TO KNOW THE ARTERIAL PHASE 128-SLICE MULTIDETECTOR CT ANGIOGRAPHY DIAGNOSTIC ACCURACY FOR DETECTING THROMBUS IN LEFT ATRIAL APPENDAGES IN PATIENTS PREPARED FOR ATRIAL FIBRILLATION ABLATION

Field: Medicine (Health Sciences)

Objective: The aim of this study is to determine the Arterial Phase 128-Slice Multidetector CT Angiography diagnostic accuracy for detecting thrombus in Left Atrial Appendage in patients prepared for Atrial Fibrillation Ablation. Place and duration: In the Radiology department of Chaudhry Pervaiz Elahi Institute of Cardiology (CPEIC), Multan in collaboration with Cardiology department for one year duration from October 2017 to October 2018. Methods: The accuracy of MDCT variability in the left atrial thrombus evaluation before AFA and its investigation was done. Before the procedure, 50 MDCT and transesophageal echocardiography examinations were performed. All MDCT images were reviewed by 3 experienced observers to detect the thrombus presence in the left atrial appendage, and transesophageal echocardiograms (TEE) were reviewed by two different readers, which were taken as reference standards. For clinical data; all observers were blinded to and each other. Results: Inter-observer variability was low between the 3 readers of MDCT (P = 0.001, highest kappa statistic, 0.43). Diagnostic accuracy was much different with sensitivities from 100% to 50% and with specificities from 86% to 45%. The ETE reader contract was 97%. Conclusion: MDCT has only a modest diagnostic accuracy and high interobserver variability for detecting left atrial appendage thrombus in subjects done with AFA procedure. The accuracy of MDCT affected by potential factors includes the image quality and the problem in differentiating the clot from the pectinate muscle. It is supposed that MDCT is not the most appropriate procedure for the left atrial thrombus detection by using interpretation standards and existing techniques. Key Words: MDCT, Arterial Phase, diagnostic accuracy, Radiology.
Oil Price Forecasting based on Improved SARIMA Model

Field: Decision Sciences (Social Sciences)

Oil Price is important to countries and people. As Black Gold, Oil is considered the blood of the industry. People in modern cities are surrounded by crude oil and its derivatives, such as petrol for cars, plastic products for storing food, etc. Thus, the changing price of oil can have a profound effect on people and countries. The prediction of oil prices can lessen the impact. Once people and the government know the future price of oil, then people and government can adjust their behavior. This study leverages the Seasonal Autoregressive Integrated Moving Average (SARIMA) model to find the parameters of estimation and forecasts. The study uses Brent crude oil prices from May 1987 to July 2022. The study result shows that the price of oil is hard to predict based on the Brent crude oil prices. The study also discussed some protentional reasons why the SARIMA model cannot predict the price so accurately even if the method is correct.
Angiogenesis and Vascularity for Tissue Engineering Applications

Field: Medicine (Health Sciences)

Tissue engineering is a field of medicine that has experienced significant growth in prominence over the past three decades.Though traditional interventions exist for many medical maladies, tissue engineering aims to combat such disorders through the synthesis of body tissues and organs, resulting in functional implants.Tissue engineering takes an innovative approach, often utilizing autologous stem cells for tissue construction or materials that are biocompatible while avoiding immune rejection (Nomi et al., 2002).Despite its immense successes, a major hurdle still faces tissue engineering.Large volumes of implanted tissue are unable to stimulate the formation of necessary blood vessels required for their survival.In the body, naturally occurring, equivalent vascular networks serve vital functions in gas and nutrient exchange, metabolic processes, and waste expulsion.Though individual, large vessels have been successfully engineered for implant, it is still exceptionally difficult to fashion a stable and sustainable network of vessels for large volumes of tissue (Nomi et al., 2002).Neovascularization after tissue damage requires a level of positive and negative control that has not been successfully replicated in a laboratory environment to date.As such, rapid de novo synthesis of a controlled, established vascular network remains a challenge today.Angiogenesis is the morphogenic process of forming new blood vessels from pre-existing ones (Laschke et al., 2006;Dai and Rabie, 2007;Li and Rabie, 2007).This event plays an important, normal physiological role in wound healing, tissue repair, pregnancy, and exercise (Ferrara and Davis-Smyth, 1997), and exists in contrast to vasculogenesis (the formation of the every first blood vessels in the body, and especially predominant in embryological development).Yet, the abuse of angiogenesis, leading to an uncontrolled vascular formation as a consequence of epigenetic influence, nucleotide polymorphisms, or endocrine irregularities can also result in tumor formation (Verbridge et al., 2010).However, angiogenesis is clearly an activity that is central to development and tissue maintenance.Successful modulation of angiogenesis can have profound therapeutic outcomes for organs and tissues deprived of an adequate, stable vasculature.Studies from the last two decades have shown that the manipulation of various factors directly influences angiogenic outcome.www.intechopen.com
Relationship between hypoxia inducible factor-1α and angiogenesis of cervical carcinoma in different altitudes areas

Field: Medicine (Health Sciences)

Objective:To explore the relationship between hypoxia inducible factor-1α (HIF-1α) expression and microvessel density (MVD) of cervical carcinoma in different altitudes areas.Methods:The expression levels of HIF-1α and VEGF were detected by immunostaining and MVD of cervical carcinoma was marked by CD 34 monocloning antibody.Results:There was significant difference in levels of HIF-1α and VEGF in cervical carcinoma among different altitudes areas (P0.05); there was a positive correlation between HIF-1α and VEGF.There was significant difference in MVD in HIF-1α or VEGF positive tumor tissues among different altitudes areas.Conclusion:Detection of HIF-1α in high altitude areas plays an important role for early diagnosis and prevention of cervical carcinoma.
Comparison of the recently proposed super-Marx generator approach to thermonuclear ignition with the deuterium-tritium laser fusion-fission hybrid concept by the Lawrence Livermore National Laboratory

Field: Physics and Astronomy (Physical Sciences)

The recently proposed super-Marx generator pure deuterium microdetonation ignition concept is compared to the Lawrence Livermore National Ignition Facility (NIF) Laser deuterium-tritium fusion-fission hybrid concept (LIFE). In a super-Marx generator, a large number of ordinary Marx generators charge up a much larger second stage ultrahigh voltage Marx generator from which for the ignition of a pure deuterium microexplosion an intense GeV ion beam can be extracted. Typical examples of the LIFE concept are a fusion gain of 30 and a fission gain of 10, making up a total gain of 300, with about ten times more energy released into fission as compared to fusion. This means the substantial release of fission products, as in fissionless pure fission reactors. In the super-Marx approach for the ignition of pure deuterium microdetonation, a gain of the same magnitude can, in theory, be reached. If feasible, the super-Marx generator deuterium ignition approach would make lasers obsolete as a means for the ignition of thermonuclear microexplosions.
Approximating Regret Minimizing Sets: A Happiness Perspective

Field: Computer Science (Physical Sciences)

A Regret Minimizing Set (RMS) is a useful concept in which a smaller subset of a database is selected while mostly preserving the best scores along every possible utility function. In this paper, we study the $k$-Regret Minimizing Sets ($k$-RMS) and Average Regret Minimizing Sets (ARMS) problems. $k$-RMS selects $r$ records from a database such that the maximum regret ratio between the $k$-th best score in the database and the best score in the selected records for any possible utility function is minimized. Meanwhile, ARMS minimizes the average of this ratio within a distribution of utility functions. Particularly, we study approximation algorithms for $k$-RMS and ARMS from the perspective of approximating the happiness ratio, which is equivalent to one minus the regret ratio. In this paper, we show that the problem of approximating the happiness of a $k$-RMS within any finite factor is NP-Hard when the dimensionality of the database is unconstrained and extend the result to an inapproximability proof for the regret. We then provide approximation algorithms for approximating the happiness of ARMS with better approximation ratios and time complexities than known algorithms for approximating the regret. We further provide dataset reduction schemes which can be used to reduce the runtime of existing heuristic based algorithms, as well as to derive polynomial-time approximation schemes for $k$-RMS when dimensionality is fixed. Finally, we provide experimental validation.
Efficacy and tolerability of anti-CGRP monoclonal antibodies in patients aged ≥65 years with episodic or chronic migraine (P7-12.012)

Field: Medicine (Health Sciences)

Objective:

To assess the efficacy and tolerability of three anti-CGRP monoclonal antibody (mAb) therapies (erenumab, fremanezumab, galcanezumab) in patients ≥65 years (O65) compared to patients <65 (U65) with episodic migraine (EM) and chronic migraine (CM).

Background:

Despite decreasing prevalence of migraine with advancing age, there still remains a significant proportion of individuals aged ≥65 years with migraine. Treatment of this population is difficult given associated numerous comorbidities, polypharmacy, and altered pharmacokinetics. This age group is often excluded from clinical trials, limiting evidence regarding efficacy, safety, and tolerability of migraine treatments.

Design/Methods:

Patients who were treated with an anti-CGRP mAb between June 2018 and December 2021 had their electronic medical records extracted. The cohort was grouped into daily (n=1303) and non-daily (n=1708) migraines, then further separated between O65 (n=304, 70.81 ± 4.74 years) or U65 (n=2707, 44.33 ± 11.71 years) at their treatment start date. The groups were compared with a Mann-Whitney test.

Results:

There was no significant difference (p=0.8247) in the migraine days reduced for non-daily migraine patients O65 (8.44 ± 6.70 less MMD) or U65 (8.37 ± 6.76 less MMD). There was not a significant difference (p=0.5853) in the reduction of migraine days for daily migraineurs O65 (12.53 ± 12.18 less MMD) or U65 (13.35 ± 11.72 less MMD). There were adverse reactions noted (95/3012,1.6% O65, 3.3% U65) with the most common side effects being injection site pain/reactions (38/95) and constipation (35/95). No serious adverse events were noted in our cohort in the 6 months of anti-CGRP mAb use.

Conclusions:

This retrospective analysis provides real-world evidence that treatment with erenumab, fremanezumab, and galcanezumab is as efficacious and well-tolerated in patients O65 compared to patients U65 with EM or CM. This data may help guide choice of migraine treatment in older populations. Disclosure: Dr. Biswas has nothing to disclose. Miss Salim has nothing to disclose. Dr. Hennessy has nothing to disclose. Dr. Suneja has nothing to disclose. Dr. Ahmed has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Abbvie. Dr. Ahmed has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biohaven. Ignacio Mata has nothing to disclose.
The effects of climate variability on zooplankton and basking shark (Cetorhinus maximus) relative abundance off southwest Britain

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract At small spatial scales basking sharks ( Cetorhinus maximus ) forage selectively on zooplankton along thermal fronts, but the factors influencing broader scale patterns in their abundance and distribution remain largely unknown. Using long‐term sightings data collected off southwest Britain between 1988 and 2001, we show that the number of basking sharks recorded was highly correlated with abiotic factors, principally sea surface temperature (SST) and the lagged effect of SST in the previous month, but only very weakly to zooplankton density. This suggests that the changes in number of basking sharks recorded over large spatio‐temporal scales are more closely related to the availability of climate‐driven thermal resources than prey availability, whereas the converse is supported by previous studies at local scales. Taken together, these results imply scale‐dependent behavioural responses in basking sharks, with small‐scale foraging movements linked by broad scale responses to temperature variation.
Anaisis Resiko Penjualan, Perputaran Piutang Terhadap Profitabilitas Perusahaan

Field: Business, Management and Accounting (Social Sciences)

The purpose of this study is to determine the effect of the risk of sales, accounts receivable turnover to the company's profitability. case studies on PT.Tiga Pilar Sejahtera Tbk, PT.Mayora Indah Tbk, and Aneka Niaga Tbk PT.Prasidha. To determine how much influence the risk of sales, accounts receivable turnover to the company profitabilias PT.Tiga Pilar Sejahtera Tbk, PT.Mayora Indah Tbk, and PT.Prasidha Aneka Niaga Tbk. The results showed that PT.Tiga Pilar Sejahtera Tbk, PT.Mayora Indah Tbk, and PT.Prasidha Aneka Niaga Tbk has a value of R Square of 0.313 or 31.3% of sales and that means risk variables were able to explain the variable accounts receivable turnover of 0,313 corporate profitability or 31.3%. While the remaining 0.687 or 68.7% is influenced by other factors. Evaluation results of this study indicate that PT.Tiga Pilar Sejahtera Tbk, PT.Mayora Indah Tbk, and PT.Prasidha Aneka Niaga Tbk are expected to be more effective in managing their receivables turnover to increase sale, thus profits generate will have more leverage and profitability can be increased. Keywords: Risk Sales, Accounts Receivable Turnover, Profitability
LHD EB-NPA #108623.1

Field: Physics and Astronomy (Physical Sciences)

To study fast ion confinement and transport mechanisms both in quiescent plasmas and in the presence of magneto-hydrodynamic (MHD) activity, an electric field parallel to the magnetic field type neutral particle analyzer (E||B-NPA) was installed using Micro-Channel Plates (MCPs) in the Large Helical Device (LHD). The E||B-NPA is an established diagnostic used to measure the energy distribution of charge exchange neutral particles escaping from plasmas corresponding to hydrogen, deuterium, and tritium, respectively.
Computer simulation of the NASA water vapor electrolysis reactor

Field: Energy (Physical Sciences)

A digital computer simulation of the water vapor electrolysis reactor, an oxygen regenerator to be used in extended-mission manned spacecraft, was developed as a design tool and as a means for predicting response to unusual operating conditions. Finite increment analysis was applied to the mass, heat, and momentum transfer processes of the unit, yielding systems of non-linear algebraic equations defining the reactor. Pseudo-linear Seidel and non linear Rudd iteration schemes provided solutions to the descriptive equations. Compared with experimental data, the model predicted measurable quantities within one percent and, additionally, yielded information never before measured.
Tissue Culture and Plant Regeneration of the Root,Stem and Leaf of Carrot Seedlings

Field: Agricultural and Biological Sciences (Life Sciences)

[Objective] The aim was to study plant regeneration of carrot.[Method] The root,stem and leaf of two month old seedlings were taken as explants.Effect of different medium and different explants on callus induction and callus differentiation was analyzed.[Result] The three explants could induce callus.The stem as explants was the best for callus quality,its rate of callus induction and differentiation rate were the highest.[Conclusion] The callus induction and regeneration system of carrot seedlings was established,which lays foundation for the future experiments.
Spectral Singularities and CPA-Laser Action in a Weakly Nonlinear PT-Symmetric Bilayer Slab

Field: Physics and Astronomy (Physical Sciences)

We study optical spectral singularities of a weakly nonlinear PT-symmetric bilinear planar slab of optically active material. In particular, we derive the lasing threshold condition and calculate the laser output intensity. These reveal the following unexpected features of the system: 1. For the case that the real part of the refractive index $η$ of the layers are equal to unity, the presence of the lossy layer decreases the threshold gain; 2. For the more commonly encountered situations when $η-1$ is much larger than the magnitude of the imaginary part of the refractive index, the threshold gain coefficient is a function of $η$ that has a local minimum. The latter is in sharp contrast to the threshold gain coefficient of a homogeneous slab of gain material which is a decreasing function of $η$. We use these results to comment on the effect of nonlinearity on the prospects of using this system as a CPA-laser.
Botulism and Botulism-like Illness in Chronic Drug Abusers

Field: Medicine (Health Sciences)

illness characterized by a symmetric descending paralysis in six drug abusers from widely separated geographic areas. Botulism was confirmed in two patients; type B botulinal toxin was found and Clostridium botulinum was isolated from a small abscess in one, and type A botulinal toxin was found in the serum of the other. The clinical illness in the remaining four patients, although not laboratory confirmed, was also compatible with botulism. None of the patients had histories suggestive of foodborne botulism, and wound botulism was suspected as the cause of illness. There are several reports of tetanus associated with parenteral drug abuse; wound botulism is another toxin-mediated clostridial infection that may occur as a complication of chronic drug abuse. P A R E N T E R A L DRUG ABUSERS are at risk for developing