jimnoneill/paper-to-field-training huggingface dataset:
Decentralized equalization for massive MU-MIMO on FPGA

Field: Computer Science (Physical Sciences)

Massive multi-user multiple-input multiple-output (MU-MIMO) relies on large antenna arrays that serve tens of user equipments in the same time-frequency resource. The presence of hundreds of antenna elements and radio-frequency (RF) chains at the base station (BS) enables high spectral efficiency via fine-grained beamforming, but poses significant practical implementation challenges. In particular, conventional linear equalization algorithms used in the massive MU-MIMO uplink (users transmit to the BS), such as zero-forcing, typically require centralized architectures, which cause excessively high computational complexity and interconnect bandwidth between the baseband processing unit and the RF chains. In order to mitigate the complexity and bandwidth bottlenecks, we propose a VLSI design of a decentralized feed-forward architecture and a parallel equalization algorithm relying on large-MIMO approximate message passing (LAMA). We use high-level synthesis (HLS) to develop the VLSI architecture and provide corresponding FPGA implementation results. Our results demonstrate that the proposed decentralized LAMA equalizer achieves competitive performance and complexity as existing centralized solutions that have been designed on register-transfer level.
From fact to narrative: the production of news and the effects on the sense of reality

Field: Social Sciences (Social Sciences)

Abstract In this article I discuss the relationship between journalism, occurrence, and reality from the analysis of the news production operations that the portal of the Argentine daily La Nación made of the Cocaine Case of Puerta 8, on February 2, 2022, in Buenos Aires. I seek to answer how journalism operates the production of news about the event and what effects of meaning it produces on the sense of reality. Assuming that reality is a social construction (Berger; Luckmann, 1985) and that the event is simultaneously fact and narrative (Quéré, 2006; 2011), I adopt four analytical categories: subjects and objects -- implicated in the fact in its indicial character; and concept and strategy -- which concern the narrative as a production of meaning. It is in the articulation of these categories in recognition and production operations that journalism participates in a peculiar way in the reiteration and stabilization of a common sense about reality.
Studies towards the Synthesis of (+)‐Lochnerine

Field: Chemistry (Physical Sciences)

Abstract The efforts directed towards the stereoselective synthesis of (+)‐lochnerine, a sarpagine alkaloid is disclosed. The synthesis was designed utilizing an intramolecular catalytic hydroamination of an alkene by an oxazolidine, derived in situ from an unsaturated aldehyde, as the key step. The other key steps of the sequence include substrate‐controlled, Lewis acid promoted C3 allylation to secure the C3/C5 syn ‐disubstituted product, Kulinkovich and ring‐closing metathesis reactions.
Defenders of the Race: Jewish Doctors and Race Science in Fin-de-Siècle Europe. By John M. Efron. New Haven and London: Yale University Press. 1994. Pp. xii + 255. $30.00. ISBN 0-300-5440-8.

Field: Arts and Humanities (Social Sciences)

Defenders of the Race: Jewish Doctors and Race Science in Fin-de-Siècle Europe. By John M. Efron. New Haven and London: Yale University Press. 1994. Pp. xii + 255. $30.00. ISBN 0-300-5440-8. - Volume 29 Issue 2
Bleeding after endoscopic sphincterotomy.

Field: Medicine (Health Sciences)

A total of 194 patients who underwent 235 endoscopic sphincterotomies for common bile duct (CBD) stones were reviewed with respect to bleeding after the procedure. Evidence of bleeding was found in 21, but was occult in 7. Of the 14 patients with overt bleeding, 6 required operation and 2 died. There was also one death prior to surgery. Early consultation with surgical colleagues, observance of the usual surgical criteria for upper gastro-intestinal haemorrhage and the use of non-absorbable suture material to achieve haemostasis may reduce the morbidity and mortality of this complication of endoscopic sphincterotomy.
P28 | Glecaprevir/pibrentasvir in HCV+ Lucanian patients

Field: Medicine (Health Sciences)

Study Background and Purpose: The objective of our work is to demonstrate the therapeutic efficacy and safety of the all-genotype antiviral therapy (glecaprevir-pibrentasvir) (Maviret) in a cohort of 200 HCV-positive patients residing in the Basilicata region in real-life.Materials and Methods: The enlistment period is between January 2020 and October 2023. The duration of treatment is 8 weeks (short-therapy). 200 patients were enrolled (110 M; 91 F). The genotypes found were: G1 93 (47%), G2 58 (29%), G3 41 (21%), G4 3 (4%). The degrees of fibrosis were assessed with Fibroscan (Echosens): F0 34 (17%), F1 60 (30%), F2 32 (16%), F3 25 (13%), F4 49 (25%).Results: Sustained virological response (SVR) – undetectable viremia – is assessed at 12 weeks after the discontinuation of antiviral treatment in 100% of the treated population. Sustained virological response was not influenced by the degree of fibrosis, viremia, genotype, age, or sex. The safety of antiviral drugs was absolute (absence of adverse events).Conclusions: The therapeutic efficacy and safety of the pangenotypic antiviral regimen (glecaprevir-pibrentasvir) are absolute even in real-life settings. Virus clearance can alter the natural history of chronic HCV-positive hepatitis, which over time is burdened by severe complications (ascites, hepatocellular carcinoma, hepatic metabolic decompensation) that reduce life expectancy.
Abstract 208: The function of p53 is intact in murine basal cell carcinomas in IR-treated Ptch1+/- mice

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Basal cell carcinomas (BCC) are the most common cancer among people of European ancestry. Although mutational activation of Hedgehog (HH) signaling is pivotal for BCC carcinogenesis, p53 mutations also frequently are present in human and mouse BCCs. In humans, these p53 mutations are frequently of a “UV-signature” type, and human BCCs typically arise in sun-damaged skin containing epidermal clones of p53 mutant cells, implying that p53 is a crucial BCC tumor suppressor. In line with this notion, we found that deletion of p53 specifically in K14-expressing keratinocytes dramatically accelerates BCC carcinogenesis in ionizing radiation (IR)-treated Ptch1+/- mice. In IR-treated Ptch1+/- mice without p53 deletion, visible BCCs can also arise from but with longer tumor latency (9m vs. 5m) and a lower tumor incidence (10% vs. 100%) and mutiplicity. However it is not known whether loss of p53 signaling activity is required for the development of visible BCCs in p53+/+ mice. To address this question, we compared p53 signaling activity in IR-induced BCCs in Ptch1+/- p53+/+ mice vs. in BCCs in Ptch1+/- p53-/- mice after a second, DNA-damaging dose of IR. Using immunohistochemistry, we found the expected minimal IR-induced expression of p53, Puma, and Noxa as well as TUNEL-detected apoptosis in BCCs of p53-deleted mice. By contrast, IR induced robust expression of p53, Noxa, Puma, and apoptosis in BCCs from Ptch1+/- p53-intact mice. Without IR exposure, BCCs in p53+/+ mice had scattered p53+ cells and low level of expression of Puma and Noxa but no TUNEL+ cells. Our data thus suggest that IR-induced BCCs generated in Ptch1+/- p53+/+ mice retain their functional p53 signaling capacity and that these tumors are able to evade an intact DNA damage response. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 208. doi:10.1158/1538-7445.AM2011-208
Parental feeding decisions in dunnocks from a resource availability perspective: assessing the role of nestling tongue spots and body size

Field: Agricultural and Biological Sciences (Life Sciences)

A recent comparative study found that when resources are limited, parents primarily allocate food to superior nestlings, whereas when resources are abundant, parents evenly allocate food to all nestlings, putting forward what we refer to as the resource availability hypothesis (RAH). This ecological perspective adds valuable insights to the two classical hypotheses, sexual conflict and parent–offspring conflict, that explain the diversity of feeding patterns observed in nature. We investigated the parental allocation decisions between monogamous pairs and polyandrous trios of dunnocks. We first assessed whether the number of spots on the tongues of nestlings signals condition to the breeding parents. We then explored the RAH in an intra-specific context. We found evidence to suggest that the number of nestling tongue spots signals condition to breeding parents. We also found that monogamous and polyandrous females and polyandrous males prioritized nestlings in better condition, yet monogamous males fed nestlings evenly. This finding is consistent with the RAH in our population if monogamous males secure more resources due to their superior quality, thus resulting in the even feeding of nestlings. Another explanation for the observed parental feeding decisions that is indirectly associated with the RAH is sexual conflict (the uncertainty of paternity). Finally, we found that an assumption regarding feeding patterns in dunnocks that was established in another population was not fulfilled here; thus, it is worth noting that testing assumptions is a vital step towards assessing the generality of former findings, paving the way to credible scientific practice.
Factors influencing the acceptance of Fintech lending platform in Indonesia: an adoption of technology acceptance model

Field: Business, Management and Accounting (Social Sciences)

Indonesian Fintech lending has grown rapidly. However, 50.9% of Indonesians do not have bank accounts (Google, Temasek, & Bain Company, 2019). It illustrates that untapped financial capacity still exists, giving the Fintech lending industry a great opportunity to grow. To increase Fintech lending adoption, this research examines how Indonesians adopt Fintech lending using a modified technology acceptance model (TAM). The survey yielded 200 PLS-SEM responses. In this study, Fintech lending adoption was influenced by perceived usefulness, trust, brand image, perceived risk, and government/regulator support through user attitude. By improving Indonesia's financial inclusion and economy, the global economy will also increase efficiently.
EP1075 Immunohistochemistry improves specificity in the diagnosis of preneoplastic fallopian tube lesions of BRCA mutation carriers

Field: Medicine (Health Sciences)

Introduction/Background

Serous Tubal Intraepithelial Carcinoma (STIC) is considered the main precursor of high-grade serous carcinoma (HGSC). There are no standardized diagnostic criteria; an algorithm combining histological and immunohistochemical (IHC) analysis has been proposed by Kurman to improve the standardization. In women undergoing Risk Reducing Salpingo Oophorechtomy (RRSO), the diagnosis of STIC is essential for the assessment of the risk of recurrence in this group of women.

Methodology

A retrospective study was conducted in two Gynaecological Oncology Units (Mauriziano Hospital Torino and IRCC Candiolo, Italy). Pathological reports of the fallopian tubes of 128 BRCA mutation carriers/high risk women (who underwent RRSO or surgery for ovarian cancer) and 222 women at low risk for the development of breast and ovarian cancer (who underwent surgery for ovarian cancer or benign diseases) were analyzed searching hyperplasia, atypia, dysplasia, STIC and tubal carcinoma and classifying these lesions as not suspicious/suspicious/unequivocally STIC. Subsequently, in high risk patients with histological alterations, IHC stains (p53 and Ki67 index) were performed, to apply Kurman9s algorithm.

Results

Prevalence of pathological tubal lesions was higher in BRCA/ high risk patients compared to low-risk (14,8% vs. 4% p=0.0004; OR 4,2 (IC 1,8–9,4)). After IHC analysis 78.6% of 'not suspicious for STIC' alterations, were defined as normal/reactive epithelium. The remaining lesions (21.4%) were classified as Serous Tubal Intraepithelial Lesions (STIL). The Cohen concordance index K between histological diagnosis alone and its association with IHC was 0,019.

Conclusion

The routinely association of IHC and histological analysis may help pathologists in producing more congruous and reproducible diagnoses, improving the assessment of atypical intermediate tubal lesions. Since the prognosis and the correct management of women undergoing RRSO diagnosed with STIC is still debated, this new type of combined technique of analysis may influence clinical attitudes when STIL or STIC are found.

Disclosure

Nothing to disclose
Neurotrophins and neurotrophin receptors in some neural crest‐derived tumours (ganglioneuroma, phaeochromocytoma and paraganglioma)

Field: Medicine (Health Sciences)

Aim This study analyses the occurrence and distribution of neurotrophins and their receptors in some types of tumours of neural‐crest derived cells. Methods and results Light microscopy immunohistochemistry associated with quantitative image analysis was used to study the expression of neurotrophins (nerve growth factor, brain‐derived neurotrophic factor and neurotrophin (NT)‐3) and their cognate receptors (p75 LNGFR , TrkA, TrkB and TrkC) in histologically defined ganglioneuroma, phaeochromocytoma and paraganglioma. The material was fixed in 10% formaldehyde, paraffin‐embedded and processed for indirect peroxidase immunohistochemistry using a battery of poly‐ and monoclonal antibodies to detect neurotrophins and their receptors, as well as some neuronal, endocrine and glial cell markers. A subpopulation of cells in phaeochromocytomas and ganglioneuromas expressed NT‐3, but not other neurotrophins, while in paragangliomas no neurotrophins were detected. Regarding neurotrophin receptors, all tumours lacked p75 LNGFR , except for the ganglionic part of a case of mixed phaeochromocytoma, whereas they displayed TrkA (two of two ganglioneuromas, six of nine phaeochomocytomas and three of four paragangliomas). Furthermore, TrkC was regularly detected in a neuronal subpopulation in ganglioneuroma. Interestingly, the percentage of neurones expressing TrkA and TrkC was increased with respect to normal tissues in ganglioneuromas, as well as the percentage of the area occupied by TrkA‐immunoreactive cells in the phaeochromocytomas. Conclusion The pattern of expression of neurotrophins and neurotrophin receptors in the analysed tumours basically matches that of sympathetic neurones, adrenal chromaffin cells and paraganglionic cells, and suggests responsiveness of these cells to neurotrophins. Nevertheless, the function of TrkA and TrkC in regulating the biology of these tumours, if any, remains to be elucidated.
Peroxynitrite-Induced Reactions of Synthetic Oligonucleotides Containing 8-Oxoguanine

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

8-Oxoguanine (8-oxo-G) is one of the most common DNA lesions present in normal tissues due to exposure to reactive oxygen species. Studies at this and other laboratories suggest that 8-oxo-G is highly susceptible to secondary oxidation, making it a likely target for endogenous oxidizing agents, such as peroxynitrite (ONOO-). Synthetic oligonucleotides containing 8-oxoguanine were treated with ONOO-, and the reaction products were analyzed by liquid chromatography/electrospray ionization mass spectrometry (LC/ESI--MS). CCACAACXCAAA, CCAAAGGXAGCAG, CCAAAXGGAGCAG, and TCCCGAGCGGCCAAAGGXAGCAG (X is 8-oxo-G) were found to readily react with peroxynitrite via the same transformations as those observed for free 8-oxo-2'-deoxyguanosine. The composition of the reaction mixtures was a function of ONOO- concentration and of the storage time after exposure. The oligonucleotide products isolated at low [ONOO-]/[DNA] ratios (<5) were tentatively assigned as containing 3a-hydroxy-5-imino-3,3a,4,5-tetrahydro-1H-imidazo[4, 5d]imidazol-2-one, 5-iminoimidazolidine-2,4-dione, and its hydrolytic product, oxaluric acid. At a [ONOO-]/[DNA] ratio of >10, 2,4,6-trioxo[1,3,5]triazinane-1-carboxamidine- and cyanuric acid-containing oligomers were the major products. The exact location of a modified base within a DNA sequence was determined using exonuclease digestion of oligonucleotide products followed by LC/ESI--MS analysis of the fragments. For all 8-oxo-G-containing oligomers, independent of the sequence, the reactions with ONOO- took place at the 8-oxo-G residues. These results suggest that 8-oxo-G, if present in DNA, is rapidly oxidized by peroxynitrite and that oxaluric acid is a likely secondary oxidation product of 8-oxo-G under physiological conditions.
Kegiatan Penapisan Kesehatan Mental Mengenai Depresi Pada Kelompok Lanjut Usia

Field: Health Professions (Health Sciences)

Depression is a common mental disorder in the elderly, associated with emotional distress, increased health care costs, the risk of suicide, and death from other causes. Depression in the elderly is characterised by persistent sadness, helplessness, anhedonia, changes in appetite, sleep disturbances, psychomotor retardation or agitation, fatigue, impaired concentration, and suicidal ideation. Prevalence varies between 7 and 30%, higher in women. Risk factors include bereavement, social isolation, and somatic diseases, which are more common in old age. Depression increases the risk of dementia, morbidity, and mortality, emphasising the need for early screening. This activity uses the PDCA (Plan-Do-Check-Act) method to screen for depression in 61 elderly participants at the Hana Nursing Home using the Geriatric Depression Scale (GDS) questionnaire. The examination results revealed mild, moderate, and severe depression in 8 people (13.11%), 4 people (6.56%), and 2 people (3.28%), respectively. Early detection using GDS is essential for timely intervention, including counselling and medical advice, to improve quality of life and reduce depression-related morbidity and mortality in the elderly population.
Technologies for the Introduction of Digitalized Cultural Heritage to Visually Impaired People

Field: Computer Science (Physical Sciences)

This paper presents the place of technologies and digitalization for the creation of an opportunity for visual impaired people to become acquainted with the cultural heritage not only as text and as sound but also images. A concept for hardware realization of graphic tactile display is outlined based on a technology using tactile actuators bi-stable, solenoids and PIC based control board. The selected algorithm for series activation of each row of display allows using minimal number of active components to set and reset the solenoids and make possible the representation of an image, described additionally through text to sound readings of an object description.
Hybrid Paddy disease classification using optimized statistical feature based transformation technique with explainable AI

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Agricultural productivity is at risk from plant diseases all across the world, but it is particularly harmful in countries that are developing where farming is crucial to the economy. Avoiding crop failure due to microbes, viruses, fungi, or environmental stress requires the prompt detection of paddy leaf diseases. Traditional disease classification relies on expert knowledge, which farmers may not always have access to. This research proposes a machine learning strategy based on Explainable AI that can assist farmers quickly diagnose and manage rice leaf diseases. To enhance predictive performance by transforming features, an improved Owl Search Optimization (IOSO) algorithm is used. This method not only yields consistent outcomes, but it also provides insights into its decisions, which helps the user better understand and trust the data. The Yeo-Johnson technique is used to alter the statistical information acquired from each image. The next step is to use a Cat Boost classifier to sort the features. Using SHAP analysis and the Cat Boost classifier, this study delves deeper into the model’s classification process and the effects of each feature on the model’s operation. The ideal transformation method substantially improved performance, leading to an accuracy of up to 98.76%, even though the original model showed a balanced accuracy of less than 75%. This method proved to be the most effective in correctly identifying paddy leaf illnesses, surpassing other models such as SVM, Random Forest, and XGBoost.
Howdy, Robo-Partner: exploring artificial companionship and its stress-alleviating potential for service employees

Field: Psychology (Social Sciences)

Purpose The emergence of new generations of artificial intelligence (AI), such as ChatGPT or Copilot has brought about a wave of innovation in the service workplace. These robotic agents can serve as companions, helping employees cope with work-related stress. This research introduces the concept of “artificial companionship,” which explains how robotic agents can function as partners in assisting service employees to fulfill their job responsibilities and maintain their mental well-being. Design/methodology/approach This research uses a mixed methods approach grounded in social support theory from psychology and management to develop a conceptual framework for the stress-alleviating implications of artificial companionship. A qualitative employee survey is conducted to justify the relevance of the propositions. Findings This research delineates the concept of artificial companionship. It highlights four distinct roles that AI can play in companionship – instrumental, informative, caring, and intimate. Building on this foundation, the research presents a series of propositions that elucidate the potential of artificial companionship in mitigating stress among employees. Practical implications Firms should consider aligning the types of artificial companionship with the demands inherent in employees’ job responsibilities to better reinforce their resilience and sustainment in overcoming work-related challenges. Originality/value This research introduces a new perspective on artificial companionship through the lens of social support theory. It extends the current understanding of human-robot collaboration in service workspaces and derives a set of propositions to guide future investigations.