jimnoneill/paper-to-field-training huggingface dataset:
Spatial Configuration-Guided Design of Covalent Organic Framework-Based Artificial Metalloantioxidases for Inhibiting Inflammatory Cascades and Regulating Bone Homeostasis

Field: Chemistry (Physical Sciences)

Intense oxidative stress in bone tissues can trigger the hyperactivation of neutrophils, thereby causing inflammatory cascades to deteriorate bone homeostasis. Here, inspired by the catalytic centers of natural antioxidases, we introduce the spatial configuration-guided design of covalent organic framework (COF)-based artificial metalloantioxidases for inhibiting inflammatory cascades and regulating bone homeostasis. Specifically, the hexaiminohexaazatrinaphthalene COF with ruthenium coordination (S-HACOF-Ru), featuring electron-rich centers with a spatial configuration, demonstrates exceptional antioxidase-like reactive oxygen species (ROS) scavenging capabilities for efficiently mitigating the oxidative stress. As a result, S-HACOF-Ru efficiently prevents the generation of neutrophil extracellular traps and inhibits the release of myeloperoxidase (MPO). By preventing MPO-induced activation of nuclear factor-kappa B and inhibiting proinflammatory macrophage polarization, S-HACOF-Ru successfully blocks the neutrophil-macrophage inflammatory cascades. This intervention promotes bone homeostasis by a shift from bone resorption to tissue regeneration, which can efficiently inhibit alveolar bone loss in periodontal tissues and reverse cartilage damage in ankle joint cavities. We propose that this design strategy provides an intriguing avenue for developing new artificial antioxidases and biocatalytic materials with potential applications in treating a wide range of chronic inflammatory diseases.
Building a database of cancer genomic data

Field: Computer Science (Physical Sciences)

Cancer is known to be a genetic disease. Due to the inherent complexity of cancer, large-scale genomic datasets are necessary to study this disease. In this project, the goal is to firstly download publically available data about cancer and integrate them into a database. The architecture of the database was designed according to the structured nature of the data and convenience of usage. As such, the design of the database adopts a data warehousing strategy. The database design and queries will be discussed and further developments like adopting a distributed systems approach and combining both SQL and NoSQL capabilities have been briefly mentioned.
Fasciola gigantica Recombinant Abelson Tyrosine Protein Kinase (rFgAbl) Regulates Various Functions of Buffalo Peripheral Blood Mononuclear Cells

Field: Veterinary (Health Sciences)

Fasciola gigantica can modulate host immune mechanisms through excretory–secretory products (ESP). As one of the components of ESP, it is unknown whether Abelson tyrosine protein kinase (Abl) is involved in parasite–host immune interaction. To investigate the immunoregulatory function of Abl in Fasciola gigantica, we cloned and expressed the Fasciola gigantica Abl protein and assessed its effect on specific immune functions of buffalo peripheral blood mononuclear cells (PBMCs). Recombinant F. gigantica Abelson tyrosine protein kinase (rFgAbl) was expressed in Escherichia coli. Western blot analysis was performed to assess the reactivity of anti-rFgAbl antibodies with rFgAbl, serum from F. gigantica-infected buffalo, and excretion and secretion products of F. gigantica. Immunohistochemical analysis was conducted to determine the localization of FgAbl in tissues from larval stages and adult worms of F. gigantica. Furthermore, immunofluorescence analysis was utilized to evaluate the binding ability of the rFgAbl protein to buffalo peripheral blood mononuclear cells (PBMCs), as well as to investigate the effects of varying concentrations of rFgAbl protein (5, 10, 20, 40, and 80 μg/mL) on the functional responses of PBMCs. Anti-rFgAbl antibodies specifically recognize rFgAbl, serum from buffalo infected with F. gigantica, and FgESP. rFgAbl is localized in the cecum and capsule of juvenile worms, as well as in the testis and viellaria of adult worms. Additionally, rFgAbl enhances cell proliferation, migration, nitric oxide (NO) production, and phagocytosis, while also increasing the transcription levels of cytokines (IFN-γ, IL-12, TNF-α, IL-4, IL-10, and TGF-β). The results indicate that rFgAbl can influence the immune function of PBMCs. Further investigation into the immunomodulatory properties of the rFgAbl protein will enhance our understanding of the immune interaction mechanisms between trematodes and their hosts.
Promotion of vegetable seed germination by soil borne bacteria

Field: Agricultural and Biological Sciences (Life Sciences)

The objective of the study was to find out the effect of soil borne bacteria on the germination of different plant seeds, soaking time on seed germination and to recommend the best germination inducer bacteria. Six different soil borne bacterial species such as Pseudomonas sp, Bacillus coagulans, Serratia sp, Klebsiella sp, Bacillus sp and Escherichia coli and four crop seeds of Phaseolus vulgaris, Vigna sinensis, Hibiscus esculentus and Beta vulgaris were used. Surface sterilized seeds were soaked in different bacterial inocula prepared with phosphate buffer (pH-7) and allowed to colonize. After ten minutes of soaking, equal number of seeds were randomly transferred into sterile petridishes containing sterile moisten filter papers and the plates were kept in the dark for five days and subsequently subjected to light condition for another five days, at room temperature. The germination of seed and other related attributes were measured. There was a significant difference in the mean length of germ tubes (p = 0.05) of soaked seeds when compared with non infected control. Germination of H. esculentus, P. vulgaris and V. sinensis seeds were promoted by Pseudomonas sp and B. Coagulans. Germination of H. esculentus and P. vulgaris seeds could be promoted in an optimised manner by soaking with in Pseudomonas for 10 minutes and 20 minutes, respectively where as seeds of V. sinensis could be promoted by soaking with in Bacillus sp inocula for 20 minutes. Serratia sp, Klebsiella sp, B. coagulans and E.coli had no effect on seed germination.
Dimensions of Identity-Representing Belief

Field: Psychology (Social Sciences)

Recent work has proposed that there are symbolic beliefs. These beliefs do not serve primarily to track the facts in the world but rather to express the believer’s own identity. On this view, several disparate features of belief – from whether a belief is important to identity to whether it is sensitive to evidence – would be related to an underlying “symbolicness” dimension. We converted the features potentially related to symbolicness into items and asked people to rate their own beliefs on them. Study 1 found that beliefs which were high on one feature (importance) were rated higher on all the items, except for sensitivity to evidence. Study 2 found that ratings of any beliefs on almost all the items loaded onto a single, symbolicness factor, except again for evidence insensitivity. Study 3 asked participants to rate their own beliefs on all the items in Study 2 and several additional items which got at whether a belief was subjective. We recovered the symbolicness factor, but found it was largely orthogonal to the subjectivity and evidence insensitivity items. These findings suggest that most of the features we tested relate to an underlying symbolicness factor, which corresponds to whether a belief represents identity. But, surprisingly, this factor was not related to items that get at whether a belief represents facts about the world. It would seem that some beliefs express identity and track facts; some beliefs only do one of these things; and some beliefs do neither.
Correction

Field: Computer Science (Physical Sciences)

This article refers to:Forecasting conflict using a diverse machine-learning ensemble: Ensemble averaging with multiple tree-based algorithms and variance promoting data configurationsThe role of governmental weapons procurements in forecasting monthly fatalities in intrastate conflicts: A semiparametric hierarchical hurdle modelA shape-based approach to conflict forecastingRecurrent neural networks for conflict forecastingForecasting conflict in Africa with automated machine learning systemsPredicting (de-)escalation of sub-national violence using gradient boosting: Does it work?United they stand: Findings from an escalation prediction competitionHigh resolution conflict forecasting with spatial convolutions and long short-term memoryConflict forecasting with event data and spatio-temporal graph convolutional networksChallenging the status quo: Predicting violence with sparse decision-making data
ESG Information Disclosure and Corporate Financial Restatement

Field: Business, Management and Accounting (Social Sciences)

Environmental, Social, and Governance (ESG) factors are closely tied to the sustainable development of corporations and have become an increasingly important indicator for evaluating corporate sustainability, attracting growing attention from society at large. This paper examines the relationship between ESG information disclosure and financial restatement using data from A-share listed companies on the Shanghai and Shenzhen stock exchanges from 2009 to 2021. The empirical results suggest that, to a certain extent, enhanced ESG disclosure can reduce the likelihood of financial restatements. Heterogeneity tests reveal no significant differences between state-owned and non-state-owned enterprises. Further analysis indicates that ESG disclosure can increase investor attention, which in turn helps curb financial restatement behavior. Moreover, institutional investors play a moderating role in the relationship between ESG disclosure and financial restatement. These findings suggest that increasing ESG information disclosure can help listed companies reduce financial restatements and promote sustainable corporate development.
Harmonisation of critical values

Field: Health Professions (Health Sciences)

Ujednacavanje nazivlja i usuglasavanje popisa pretraga s kriticnim vrijednostima na nacionalnoj razini prvi je korak ka njihovoj harmonizaciji i na međunarodnoj razini. Objavljane nacionalne preporuke u tom su smislu vrijedne smjernice za laboratorije. Rezultati provedenih istraživanja pokazuju da usuglasavanje popisa pretraga s kriticnim vrijednostima s klinicarima i harmonizacija postupaka za izvjestavanje o kriticnim vrijednostima sukladno i međunarodnim preporukama i zahtjevima norme EN ISO 15189 bitno pridonose pravovremenome zbrinjavanju bolesnika i poboljsanju njegove sigurnosti. Harmonizacija kriticnih vrijednosti u konacnici povecava uspjesnost izvjestavanja o kriticnim vrijednostima koja postaje sigurnim indikatorom kvalitete poslijeanaliticke faze laboratorijskog procesa. Daljnja automatizacija i napredak informacijskih tehnologija (laboratorijskih i bolnickih informacijskih sustava) zasigurno donose i nove mogucnosti za daljnju harmonizaciju kriticnih vrijednosti.
V. M. Kulkarni: Studies in Sanskrit Sāhitya-Śāstra. (A collection of selected Papers relating to Sanskrit Poetics and aesthetics.) (B.L. Series, No. 1.) vil, 199 pp., errata. Patan: Bhogilal Leherchand Institute of Indology, 1983. Rs. 60.

Field: Arts and Humanities (Social Sciences)

V. M. Kulkarni: Studies in Sanskrit Sāhitya-Śāstra. (A collection of selected Papers relating to Sanskrit Poetics and aesthetics.) (B.L. Series, No. 1.) vil, 199 pp., errata. Patan: Bhogilal Leherchand Institute of Indology, 1983. Rs. 60. - Volume 48 Issue 1
Clinical Research Outcomes of Patients With ST-Elevation Myocardial Infarction Receiving and Not Receiving Reperfusion Therapy: The Importance of Examining All Patients

Field: Medicine (Health Sciences)

Background: Hospitals treating patients with ST-elevation myocardial infarction (STEMI) may show good results with reperfusion treatment (fibrinolysis or primary percutaneous coronary intervention [PPCI]), but a comprehensive evaluation should factor in outcomes of patients with STEMI who do not receive reperfusion. We compared outcomes of patients receiving and not receiving reperfusion within a complete system of STEMI care by hospital type: PPCI centres, fibrinolysis centres, centres that only transfer for PPCI, and centres providing a mix of fibrinolysis and PPCI transfer.
THE ROLE OF VIDEO CONFERENCING IN FOREIGN LANGUAGE LEARNING AMONG YOUNG STUDENTS

Field: Social Sciences (Social Sciences)

During the coronavirus pandemic research on video conferencing effects on young language learners is more than ever relevant. During the sharp transition, educators need to fully understand the benefits and possible pitfalls of video conferencing, but also overcome resistance to change through knowledge. As author Philip Pullman rightly points out, “You cannot change what you are, only what you do.” This article summarised key research and provided evidence for and against the use of video conferencing in foreign language education. Thus, it gives food for thought and reflection, as well as directions for possible interventions. However, the research was limited in terms of time and available literature, and the topic certainly requires more attention. In future, it is recommended to further research the use of multimodal interactions (sound, audio, text) in video conferencing, as well as coping strategies for dealing with the lack of interaction in the video conferencing-enabled classroom.
The nuclear envelope protein – Sun1 : its role in mechanosignaling and cytoskeletal dynamics.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The LINC (LInker of Nucleoskeleton and Cytoskeleton) complex establishes evolutionarily conserved connections between the nuclear lamina and cytoskeleton. Disruption to the LINC complex has been proposed to contribute to the molecular pathophysiology of laminopathies, a group of genetic diseases caused by mutations of the nuclear lamin A (LMNA) gene. The objective of this project is to determine how loss of a specific component of the LINC complex, Sun1, affects the interactions between the cytoskeleton and nucleus and whether this has effects on gene expression. Results suggest that, depending on the cell type, the effects of loss of Sun1 may be variable. Absence of Sun1 in myotubes results in reduced expression of lamin A/C, suggesting that interactions between them may promote the accumulation of nuclear lamins in NE. The polarization of Sun2 distribution in Sun1 KO myonuclei also suggests a possible compensatory mechanism acquired by cells lacking Sun1. Such effects were not observed in Sun1 KO fibroblasts. Furthermore, preliminary mechanotransduction studies also suggest defective mechanosignaling responses in Sun1 KO cells. Overall, results support the involvement of Sun1 in regulating cytoskeletal dynamics and gene expression. Further research would provide useful insights in the involvement of LINC complexes in the molecular pathophysiology of laminopathies.
THE IMPORTANCE OF DIRECT TAXES IN SHAPING BUDGET REVENUES

Field: Economics, Econometrics and Finance (Social Sciences)

This study investigates the critical role of direct taxes in shaping the state budget of Uzbekistan from 2015 to 2024. It examines the structure, contribution, and challenges of direct taxation—including personal income tax, corporate tax, and property tax—within the broader fiscal landscape. Utilizing a mixed-methods approach, the research evaluates the legal, economic, and institutional frameworks governing direct taxes and highlights their potential to promote equity, fiscal sustainability, and public trust. Key challenges such as tax evasion, administrative inefficiencies, and a large informal sector are analyzed, culminating in policy recommendations to strengthen Uzbekistan’s revenue system.
Exploiting High Pressures to Generate Porosity, Polymorphism, And Lattice Expansion in the Nonporous Molecular Framework Zn(CN)2

Field: Chemistry (Physical Sciences)

Systematic exploration of the molecular framework material Zn(CN)2 at high pressure has revealed several distinct series of transitions leading to five new phases: four crystalline and one amorphous. The structures of the new crystalline phases have been resolved through ab initio structural determination, combining charge flipping and direct space methods, based on synchrotron powder diffraction data. The specific transition activated under pressure depends principally on the pressure-transmitting fluid used. Without fluid or in large molecule fluids (e.g., isopropanol, ethanol, or fluorinert), the high-pressure behavior intrinsic to Zn(CN)2 is observed; the doubly interpenetrated diamondoid framework structure transforms to a distorted, orthorhombic polymorph, Zn(CN)2-II (Pbca) at ~1.50-1.58 GPa with asymmetric displacement of the bridging CN ligand and reorientation of the Zn(C/N)4 tetrahedra. In small molecule fluids (e.g., water, methanol, methanol-ethanol-water), the nonporous interpenetrated Zn(CN)2 framework can undergo reconstructive transitions to porous, non-interpenetrated polymorphs with different topologies: diamondoid (dia-Zn(CN)2, Fd3m, P(trans) ~ 1.2 GPa), londaleite (lon-Zn(CN)2, P6(3)/mmc, P(trans) ~ 0.9 GPa), and pyrite-like (pyr-Zn(CN)2, Pa3, P(trans) ~ 1.8 GPa). Remarkably, these pressure-induced transitions are associated with near 2-fold volume expansions. While an increase in volume with pressure is counterintuitive, the resulting new phases contain large fluid-filled pores, such that the combined solid + fluid volume is reduced and the inefficiencies in space filling by the interpenetrated parent phase are eliminated. That both dia-Zn(CN)2 and lon-Zn(CN)2 phases were retained upon release to ambient pressure demonstrates the potential for application of hydrostatic pressures to interpenetrated framework systems as a novel means to generate new porous materials.
Psychosocial predictors of high-risk patients undergoing orthognathic surgery.

Field: Health Professions (Health Sciences)

The purpose of this analysis was to identify a set of predictor variables that are prospectively related to postsurgical outcomes. Specifically, psychosocial characteristics were sought to predict postsurgical outcomes. The 5 Revised Symptom Checklist-90 (SCL-90-R) scales, the neuroticism score of the Eysenck Personality Inventory (EPI), the psychosocial domain score from the Sickness Impact Profile (SIP), and 4 scales from the Oral Health Status Questionnaire (OHSQ) were used as the predictors. A total of 31 male and 86 female subjects participated in this multicenter randomized trial, which compared rigid and wire fixation. Data were collected prior to placement of orthodontic appliances, 1 to 2 weeks presurgery, and at 1 week, 8 weeks, 6 months, and 2 years after surgery. Baseline oral health was used as an indicator of postsurgical oral health functioning. A path analytic model of influences on presurgical oral health was estimated (R2 = 0.43). The results suggest that presurgical screening of demographic characteristics (age, sex, and ethnicity), oral health (the OHSQ), quality of life issues (SIP), and personality features (SCL-90-R), accounts for 23% to 39% of the variance in postsurgical oral health outcomes. The path analysis conducted suggests that a patient's age, ethnicity, gender, and elevated scores on the EPI have indirect effects on postsurgical health. As determined by a 2-stage least squares regression model, 3 variables--the patient's presurgical oral health (per the OHSQ), pre- and postsurgical Global Severity Index (GSI) score from the SCL-90-R, and the psychosocial scale score from the SIP--were found to have a statistically significant impact on postsurgical outcomes. Additionally, the GSI, SIP, and OHSQ are reliable measures in predicting oral health outcomes.
From Counter-Culture to National Heritage: "La Movida" in the Museum and the Institutionalization of Irreverence

Field: Arts and Humanities (Social Sciences)

William Nichols is Assis tant Professor at Georgia State University. He has published on diverse themes like detective fiction, corpo rate culture, tourism, food, genre, and globalization in such journals as the Arizona Journal of Hispanic Cultural Studies, Revista Canadiense de Estudios Hisp?nicos, Tabla Redonda, The Journal for the Study of Food and Society, and Symposium. His manuscript, Transatlan tic Mysteries: Culture, Capi tal, and Crime in the Noir Novels of Paco Ignacio Ta ibo II and Manuel Vazquez Montalban, is forthcoming with Bucknell U P. The museum is indeed a site into which bourgeois society projects its dreams and Utopian projects. Herbert Marcuse On the Affirmative Character of Culture (1937)
Indwelling Intravenous Polyethylene Catheters

Field: Medicine (Health Sciences)

To assess complications secondary to the use of indwelling intravenous polyethylene catheters, a study was conducted in which 500 catheter tips were cultured and results correlated with data obtained in each case. A catheter colonization rate of 3.8% occurred. The major factor influencing the frequency of catheter colonization is the presence of other catheter complications, such as subcutaneous infiltrations and phlebitis. The low colonization rate is attributed in part to the nature of this hospital and its patient population, and in part to the use of a team of specially trained "IV" nurses for insertion of most and maintenance care of all intravenous catheters. Frequent observation of catheters and their immediate removal at the first sign of patient distress or catheter malfunction are essential to successfully maintaining a lowered rate of colonization, infection, and septicemia.
Physical oceanography during METEOR cruise M10/1

Field: Earth and Planetary Sciences (Physical Sciences)

During leg 1 of Meteor cruise 10 in March/April 1989 at 18°N, 30°W, the high spatial and temporal resolution of hydrographic CTD-stations indicated that the study site was in a hydrographically complex region in the transition zone between the Canary Current and the North Equatorial Current at the southern boundary of the subtropical gyre. Strong variability was found within the upper 120 m due to interleavings of warmer and saltier subtropical salinity maximum water with colder and less saline upper thermocline water. The interleavings caused unexpected nose-like temperature, salinity, nitrate and oxygen profiles yet not described in the literature. A second variability source was found in the Central Water area, because the study area was situated in the vicinity of the Central Water Boundary dividing North and South Atlantic Central Water. Hydrographic analysis of the study shows that interpretations of biological and chemical data can only be done in conjunction with high resolution CTD-profiling.