jimnoneill/paper-to-field-training huggingface dataset:
IL-17A Contributes to the Angiotensin II-induced Neurovascular Coupling impairment through Oxidative Stress

Field: Neuroscience (Life Sciences)

Abstract Hypertension, a multifactorial chronic inflammatory condition, is a risk factor for neurodegenerative diseases including stroke and Alzheimer’s disease. These diseases have been associated with higher concentration of blood interleukin (IL)-17A. However, the role that IL-17A plays in the relationship between hypertension and brain remains misunderstood. Cerebral blood flow regulation may be the crossroads of these conditions. Hypertension alters cerebral blood flow regulation including neurovascular coupling (NVC). In the present study, the effects of IL-17A on NVC in the context of hypertension induced by angiotensin (Ang) II will be examined. Our results show that the neutralization of IL-17A or the specific inhibition of its receptor prevent the Ang II- induced NVC impairment. These treatments reduce the Ang II-induced cerebral oxidative stress. Tempol and NOX-2 depletion prevent NVC impairment induced by IL-17A. These findings suggest that IL-17A, through superoxide anion production, is an important mediator of cerebrovascular dysregulation induced by Ang II.
Study on advanced soldier combat uniform

Field: Engineering (Physical Sciences)

With the advancement of technology, soldiers of the future will be constantly provided with cutting edge technology to better fit their environment and to give them an edge over their enemies. With training they are built up to have the stamina and strength to supplement technology and equipment, but during these training where they are pushed to their limits and their safety becomes a key issue. Many safety protocols have been put in place and are constantly evolving to suit the generation of today. However, even with these safety protocols, there are always casulties. With the advanced soldier uniform like the Advanced Combat Man System which was designed to meet a soldier’s operational needs, a new prototype is needed to address the soldier’s safety needs during training.
EFFECT OF CITRONELLA NANO BIOPESTICIDE AGAINST MOSAIC VIRUS AND ITS VECTOR ON PATCHOULI

Field: Agricultural and Biological Sciences (Life Sciences)

<p>The mosaic disease declines production and oil quality of patchouli. Antiviral-based citronella oil has been formulated using a spontaneous emulsification technique (nanotechnology). The previous result of the greenhouse trial showed the formula at 1-1.5 % concentrations suppressed the development of virus of about 82.5 %. The field-scale tests is necessary to be performed to validate the effectiveness of citronella nano biopesticide (CNB) against the mosaic virus and its vector on patchouli. The study was conducted in patchouli plantation at two locations (Pandeglang, Banten and Manoko, West Java). The research was arranged in a Randomized Completed Block Design (RCBD) with 6 treatments and 10 replications, each replication consisted of 50 plants. The treatments were formula of CNB at the concentration of (1) 0.5 %, (2) 1 %, (3) 1.5 %, (4) 2 %, (5) insecticide (deltamethrin 0.2 %), and (6) control. The results showed that CNB formula at 1 % concentration with a monthly application effectively suppressed the development of mosaic disease in patchouli plants, and at 2 % concentration to control rolled-leaf aphid. The lowest intensity of mosaic disease (at 1 % concentration) was in Banten (23.12 %) and in West Java (18.35 %), while in control ranged from 26.31-44.94 % (Banten) and 19.60-23.12 % (West Java). Efficacy Index (EI) in Banten ranged from 12.12-48.55 % and in West Java was 6.38-20.63 %. The lowest intensity of aphid attack was showed by insecticide and CNB at 2 % concentration. The EI of CNB was 35.33 % (Banten) and 51.71 % (West Java<strong>) </strong>respectively.</p>
Novel Mechanisms by which Estrogen Induces Antiapoptosis in Breast Cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

We investigated the mechanisms of membrane estrogen receptor signaling to breast cancer. We discovered that serine 522 of mouse ER alpha is required for membrane localization. Importantly, when expressed in MCF-7 cells, this S522A mutant ER alpha heterodimerizes with endogenous ER alpha, sequestering it from the membrane and inhibiting ERK activation by E2. This mutant has no effect on endogenous nuclear ER. We found that cyclin D1 synthesis, Cdk4 activity and G1/S progression is stimulated via ERK and inhibited by S522A mutant ER alpha expression in MCF-7 (Mol Cell Biol 23(3):1633-46, 2003). We also found that estradiol signaling to ERK involves transactivation of the EGF receptor, through Gq alpha and Gi alpha signaling to Src, Mmp activation and HB-EGF liberation. Only the E domain of ER alpha is required for these events initiated at the plasma membrane (J Biol Chem 278:2701-12, 2003).
Individual differences predict sensitivity to the uncanny valley

Field: Psychology (Social Sciences)

It can be creepy to notice that something human-looking is not real. But can sensitivity to this phenomenon, known as the uncanny valley, be predicted from superficially unrelated traits? Based on results from at least 489 participants, this study examines the relation between nine theoretically motivated trait indices and uncanny valley sensitivity, operationalized as increased eerie ratings and decreased warmth ratings for androids presented in videos. Animal Reminder Sensitivity, Neuroticism, its Anxiety facet, and Religious Fundamentalism significantly predicted uncanny valley sensitivity. In addition, Concern over Mistakes and Personal Distress significantly predicted android eerie ratings but not warmth. The structural equation model indicated that Religious Fundamentalism operates indirectly, through robot-related attitudes, to heighten uncanny valley sensitivity, while Animal Reminder Sensitivity increases eerie ratings directly. These results suggest that the uncanny valley phenomenon may operate through both sociocultural constructions and biological adaptations for threat avoidance, such as the fear and disgust systems. Trait indices that predict uncanny valley sensitivity warrant investigation by experimental methods to explicate the processes underlying the uncanny valley phenomenon.
Researches in the Field of Variable Reluctance Electrical Machines in Technical University Of Cluj

Field: Engineering (Physical Sciences)

Abstract. The variable reluctance electrical machines had an essential role in the changes in electric machine technology during the last 30 years, when digital and power electronics and computerized design methods suddenly started to expand. As new boundaries are set up in both power electronic devices and digital control, the researchers reacted with new inventions and adaptations of electrical machines, generally along the classical lines. But also new machine (in many cases variable reluctance) structures were invented during this period. In all the cases the development of novel control strategies has been the motivating force. The variable reluctance machines are rather simple, but require control system and in many cases also speed or position sensors. As electronics progresses still further, the opportunities for successful application of variable reluctance machines will still increase [1]. Researchers from Electrical machines Department, Technical University Cluj, Romania, were involved during the last 20 years in several developments in this field. A part of their research works and results are presented in this paper. The author should like to highlight that it was impossible to mention all the results in this field and the selection of those presented in the paper maybe it was subjective. 1.
Validation of Valiantzas Reference Evapotranspiration Equation under Different Climatic Conditions

Field: Agricultural and Biological Sciences (Life Sciences)

Numerous daily reference evapotranspiration (ETo) equations were developed for different climatic conditions with different performance even within the same climatic region. Their calibration and validation to the local climate usually increase their performance. The objective of this study was to evaluate Valiantzas’ daily grass ETo equation with comparison to Penman-Monteith equation at 61 weather stations across 10 countries in Africa for the period of 1980-2012. The results showed good performance of Valiantzas’ ETo equation with very low RMSE varying from 0.03 to 0.27 mm/day, low percent error PE from 0.87 to 5.46%, MBE from -0.09 to 0.23 mm/day and MAE from 0.03 to 0.23 mm/day. For the pooled data set, RMSE averaged 0.10 mm/day, mean PE was 1.95%, mean MBE was 0.02 mm/day and the mean MAE was 0.08 mm/day. These indexes indicated the very high performance of the Valiantzas’ ETo equation compared to the Penman-Monteith equation and its adaptation to very broad conditions from humid to semiarid climates. *
Effective Strategies for Enhancing the Language Learning Experience in the FSL Classroom

Field: Social Sciences (Social Sciences)

In the province of Ontario, French education maintains an important part of a student’s life as it is mandated by the Ministry of Education that all individuals learn French in either a Core, Extended or Immersion setting from Grades 4-9. Based on recent statistics from the Ontario Ministry of Education, the number of students enrolled in the Core French programs in the 2012-2013 school year is more than 3 times the amount of students following the French Immersion stream. This study focuses on FSL education in Ontario, examining student motivation in French Language Learning, and effective teaching strategies aimed at enhancing student motivation. A lack of student engagement in French language learning is detrimental to a student’s success, and is commonly influenced by the linguistic and academic situations students find themselves in, both inside and outside the classroom. The data from this qualitative study has been derived from a review of existing literature on second language acquisition and FSL education, as well as semi-structured interviews with 3 Junior/Intermediate French teachers in Toronto schools. The findings confirm the role of the teacher as key motivator in the French classroom, and favour the use of student-centered learning and peer interaction in the classroom to enhance the language learning process.
Growth and yield of sunflower (Helianthus annus L.) as influenced by nitrogen, sulphur and farmyard manure under temperate conditions

Field: Agricultural and Biological Sciences (Life Sciences)

A field experiment was conducted at the Research farm, Division of Agronomy, Sher-e-Kashmir University of Agricultural Sciences and Technology, India for two consecutive rainy (kharif) seasons of 2009 and 2010 to find out the impact of nitrogen, sulphur and farmyard manure (FYM) on growth and yield of sunflower (Helianthus annuus L.). Application of 120 kg N ha-1 significantly increased all the yield components viz., plant height, leaf area index, dry matter production, capitulum diameter, achenes capitulum-1 and 1000-seed weight. Pooled yield increased by 26% with 120 kg N but it was statistically at par with 80 kg N ha-1. With increased N dose, the oil content consistently decreased but the oil yield improved during both years. Sulphur application at the rate of 60 kg ha-1 significantly increased plant height, leaf area index and dry matter production after 25 days of sowing (DAS). All yield contributing characters viz., filled achenes capitulum-1, head diameter and 1000-seed weights were higher with 60 kg S ha-1 over 30 kg S ha-1. Seed and stalk yield with 60 kg S ha-1 were significantly higher than those of 30 kg S ha-1. Similarly, oil content and oil yield with 60kg Sha-1 was 2 and 10.5 % over 30 kg S ha-1. Application of FYM at the rate of 10 and 20 t ha-1 was at par with each other but recorded significant improvement in the plant height, leaf area index and dry matter production of sunflower after 25 days of sowing over no FYM. FYM @10 and 20 t ha-1 increased the oil yield by 11 and 5.4 %, respectively over no application. DOI: http://dx.doi.org/10.3329/sja.v11i1.18386 SAARC J. Agri., 11(1): 81-89 (2013)
Increased Occurrence of Large‐Scale Windthrows Across the Amazon Basin

Field: Environmental Science (Physical Sciences)

Abstract Convective storms with strong downdrafts create windthrows: snapped and uprooted trees that locally alter the structure, composition, and carbon balance of forests. Comparing Landsat imagery from subsequent years, we documented temporal and spatial variation in the occurrence of large (≥30 ha) windthrows across the Amazon basin from 1985 to 2020. Over 33 individual years, we detected 3179 large windthrows. Windthrow density was greatest in the central and western Amazon regions, with ∼33% of all events occurring in ∼3% of the monitored area. Return intervals for large windthrows in the same location of these “hotspot” regions are centuries to millennia, while over the rest of the Amazon they are >10,000 years. Our data demonstrate a nearly 4‐fold increase in windthrow number and affected area between 1985 (78 windthrows and 6,900 ha) and 2020 (264 events and 32,170 ha), with more events of >500 ha size since 1990. Such extremely large events (>500 ha up to 2,543 ha) are responsible for interannual variation in the overall median (84 ± 5.2 ha; ±95% CI) and mean (147 ± 13 ha) windthrow area, but we did not find significant temporal trends in the size distribution of windthrows with time. Our results document increased damage from convective storms over the past 40 years in the Amazon, filling a gap in temporal records for tropical regions. Our publicly accessible large windthrow database provides a valuable tool for exploring dynamic conditions leading to damaging storms and their ecological impact on Amazon forests.
Is microbial terroir related to geographic distance between vineyards?

Field: Agricultural and Biological Sciences (Life Sciences)

Summary While there are substantial studies suggesting that characteristics of wine are related to regional microbial community composition (microbial terroir ), there has been little discussion about what factors affect variation in regional microbial community composition. In this study, we compared the microbial community composition of leaves and berries of a grape variety (Carmenere) from six different Chilean vineyards within 35 km of each other. In order to determine relationships between spatial proximity and microbial compositional dissimilarity, we sequenced amplicons of the internal transcribed spacer (ITS) region for fungi and 16S rRNA gene for bacteria. Results showed that both the fungal and the bacterial community compositions of the studied vineyards differed, but this difference was much clearer in fungi than in bacteria. In addition, while bacterial community dissimilarity was not correlated with geographic distance, the leaf and berry fungal community dissimilarities between locations increased with geographic distance. This indicates that spatial processes play an important role in structuring the biogeographic pattern of grape‐associated fungal communities at local scales, which might in turn contribute to the local identity of wine.
Secrets of software quality: 40 innovations from IBM

Field: Computer Science (Physical Sciences)

This work features 40 innovations used by IBM, many of which originated at IBM and are being made public. The book/disk combination should arm software managers, systems administrators, CIOs and project leaders with the technical and managerial expertise they need to achieve high-quality software standards. Based on the Malcolm Baldrige Award criteria and drawing from the experience of IBM's largest software development lab, the authors describe current techniques, 13 process innovations, 15 new tools and technologies, and strategies developed by IBM for maintaining and improving quality. Using a hands-on approach, the authors explain each innovation according to the problem it solves; how it solved the problem at IBM; costs, benefits and risks; implementation advice; and references for those needing further information. For example, the book details 12 innovations from IBM that solve the problem of getting high-quality code out on time; 28 innovations showing how to improve the process of developing or testing code; and 28 innovations showing how to use better tools and methodologies for developing and testing code. Readers can learn how to tailor a quality-improvement strategy to fit their own needs, and produce higher quality code with greater efficiency, as well as 100 pitfalls to avoid.
Influence of Particle Size and Patient Dosing Technique on Lung Deposition of HFA-Beclomethasone from a Metered Dose Inhaler

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The objective of this study was to determine the lung delivery of HFA-134a-beclomethasone dipropionate (HFA-BDP) from a breath-activated inhaler (QVAR Autohaler) compared with proper and improper press and breathe (QVAR P&B) metered dose inhaler (MDI) technique. The hypothesis was that that the smaller particles of BDP from HFA-BDP would stay suspended longer in the inspiratory air of patients and thus reduce the deleterious effects of inhaler discoordination. The study was an open label, four period, cross-over design. Asthmatic patients (n = 7) with a history of asthma symptoms, an FEV-1 of >70% of predicted normal, and a history of reversibility to a beta-agonist of >or=12% were utilized. BDP was radiolabeled with technetium-99m and delivered from the QVAR Autohaler or QVAR P&B device in patients trained to reproducibly utilize coordinated and discoordinated P&B MDI technique. Patients using Autohaler MDI exhibited 60% lung deposition of BDP. Patients using coordinated technique with the P&B MDI exhibited 59% lung deposition. Patients trained to consistently actuate the P&B MDI before inhaling exhibited 37% lung deposition. Patients trained to consistently actuate the P&B MDI late in the inspiration (i.e., 1.5 sec into a 3-sec inspiration) exhibited 50% lung deposition. In conclusion, the breath-activated Autohaler automatically provided optimal BDP lung deposition of 60%. Patients with good P&B MDI technique also received optimal lung deposition of 59%. The degree of lung deposition was decreased as patients demonstrated poor inhaler technique. However patients with poor technique still received a large lung dose of BDP (i.e., >or=37%) compared with lung deposition values of 4-7% for CFC-BDP MDIs previously published and confirmed in this study.
To be amoved or not : on involved versus involved styles communation

Field: Social Sciences (Social Sciences)

ABSTRACT This thesis is about a systemic action research project regarding the new role in Sweden of safety delegates to elderly people. It studies how the supervision of the care of elderly persons was developed in one of the County Administrations Boards in Sweden - the board of Scania. In the project, two different styles of addressingelderlyelderlyelderlyoldpersons and others when seeking information from them were studied. These two styles were also studied in relation to addressing care-givers and performing inspections. We can call these two styles: ‘involved’ and ‘uninvolved’ forms of communication. The thesis emphasizes how these two styles open up different opportunities for response, and how this influences delegates in their commission in their attempts to give a better service in the care oftheelderly. The distinction between involved and uninvolved styles of address, hinges on the degree of the questioner’s or actor’s spontaneous responsiveness to the bodily expressed effects of their questioning/communication on the listener, i.e., the degree to which questioners/speakers show in their responsiveness how their listener’s reactions ‘move’ them – or as I prefer,nameit, using an old English word, ‘amove’ [1] them. When ‘amovement’ happens, it is not just a matter of all concerned feeling enlivened, feeling ‘in touch with’ life, but of all concerned sharing in a ‘living movement’ together. It is from within such an ‘amovement’ that one can be ‘amoved’ by another’s words over a ‘scenic landscape’ of human places to go… being ‘amoved’ together is like dancing together in a joint action that generates a ‘sense’ of ‘where and how to go on’. In uninvolved (monological) styles of talk the listenerpersonremains an object at a distance. Uninvolved questioning requires listeners to answer in the questioner’s terms. In involved (dialogical) communication the participants are ‘amoved’ by each other’s responsiveness. The questioning is up-close close and personal, andworkingworks, so to speak, in terms of ‘open’ questions to ‘invite’ listeners to answer in their own terms. The analysis in the thesis consistsofinmaking connections between important concepts in the literature and problematic events in the experienced social work. By a process of shifting in a ‘back and forth manner’ between crucial concepts in the literature and striking events in interpersonal interaction, I show how social workers’develop a “reflexive awareness” that aids them in providing aworksbetter service to the elderly. [1]amove — definition in Brainy Dictionary (2004). Brainy Dictionary. t.) To remove, as a person or thing, from a position.(v. t.) To dismiss from an office or station.(v. t. & i.) To move or be moved; to excite.The third alternative is in use in this thesis.
UN operations: The political‐military interface

Field: Social Sciences (Social Sciences)

The dilemmas raised by UN peacekeeping operations in Bosnia and Somalia have focused attention on the political‐military interface. This article places recent experiences in the context of the history of the United Nations’ enforcement action and its relationship with UN peacekeeping. It is divided into three parts which address UN enforcement measures from 1945 to 1991, the use of Chapter VII resolutions in the mandates of peacekeeping operations, and the challenges ahead. Through a detailed examination of case histories, specific problems are identified, remedies suggested and future options explored.
[The prevention of recurrence of calculus: results of a regional study].

Field: Medicine (Health Sciences)

The frequency of measures of prevention of stone recurrence was evaluated in 250 patients treated in one center by extra corporeal shock wave lithotripsy (ESWL). Half were recurrent stone formers (RSF). Only two thirds admitted a previous 24 h urinary analysis and less than 30% knew the result as abnormal while hypercalciuria and or hyperuricuria was later evidenced in 63%. These figures were similar in first stone and recurrent stones formers. Dietary or drug based regimen were followed by only 27.5% of RSF irrespective of the activity of the disease. This percentage was the highest (40%) in RSF known as having abnormal urinary values and the lowest (13%) in those without previous analysis. Only 17% of RSF admitted having received dietary advise after ESWL.
LHD Halpha #52312.1

Field: Physics and Astronomy (Physical Sciences)

Toroidal visible array to measure toroidal distribution of H-alpha and He-I, ratio of helium to hydrogen: H/(H+He) or D/(D+He), and particle recycling and edge tau_p. H-alpha and He-I line emissions are detected by photomultipliers passing through an interference filter. H/D influx ratio can be also minitored by resolving H-alpha and D-alpha line profiles.
Monetary Overhang

Field: Economics, Econometrics and Finance (Social Sciences)

A monetary overhang emerges when individuals jointly hold more money than they wish and all adjustment processes are rendered unavailable through price and quantity controls. While monetary overhangs can in principle be eliminated through increased real money demand, their magnitude in practice typically implies a resolution through a reduction in real money supply through a cut in the nominal money supply or through higher prices. The former is impeded by the difficulty of estimating the appropriate reduction, the latter risks triggering sustained inflation in the presence of distorted relative wage and price structures.