jimnoneill/paper-to-field-training huggingface dataset:
The effect of spatial dynamics on the behaviour of an environmentally transmitted disease

Field: Environmental Science (Physical Sciences)

Understanding the spread of pathogens through the environment is critical to a fuller comprehension of disease dynamics. However, many mathematical models of disease dynamics ignore spatial effects. We seek to expand knowledge around the interaction between the bare-nosed wombat (Vombatus ursinus) and sarcoptic mange (etiologic agent Sarcoptes scabiei), by extending an aspatial mathematical model to include spatial variation. S. scabiei was found to move through our modelled region as a spatio-temporal travelling wave, leaving behind pockets of localized host extinction, consistent with field observations. The speed of infection spread was also comparable with field research. Our model predicts that the inclusion of spatial dynamics leads to the survival and recovery of affected wombat populations when an aspatial model predicts extinction. Collectively, this research demonstrates how environmentally transmitted S. scabiei can result in travelling wave dynamics, and that inclusion of spatial variation reveals a more resilient host population than aspatial modelling approaches.
Examining Visitors' Characteristics and Behaviors in Tourist Destinations Through Mobile Phone Users' Location Data

Field: Social Sciences (Social Sciences)

This chapter uses Mobile Kukan Toukei™ (mobile spatial statistics) to collect the location data of mobile phone users in order to count the number of visitors at specific tourist destinations and examine their characteristics. Mobile Kukan Toukei is statistical population data created by an operational data of mobile phone networks. It is possible to estimate the population structure of a region by gender, age, and residence using this service of the company. The locations and characteristics of the individuals obtained herein are derived through a non-identification process, aggregation processing, and concealment processing. Therefore, it is impossible to identify specific individuals. This chapter attempts to identify the number of visitors in different periods and their characteristics based on the location data of mobile phone users collected by the mobile phone company. In addition, it also attempts to demonstrate an alternative method to more accurately infer the number of visitors in specific areas.
Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Monanchocidin A (MonA) is a novel alkaloid recently isolated from the marine sponge Monanchora pulchra. The compound reveals cytotoxic activity in genitourinary cancers including cisplatin-sensitive and -resistant germ cell tumor (GCT) cell lines, hormone-sensitive and castration-resistant prostate carcinoma cell lines and different bladder carcinoma cell lines. In contrast, non-malignant cells were significantly less sensitive. MonA is highly synergistic with cisplatin in GCT cells. Induction of autophagy at lower and lysosomal membrane permeabilization (LMP) at higher concentrations were identified as the dominating modes of action. Cytotoxicity and protein degradation could be inhibited by 3-methyladenine, an inhibitor of autophagy. LMP was confirmed by loss of acridine orange staining of lysosoms and by release of cathepsin B. In conclusion, MonA exerts cytotoxic activity by mechanisms different from "classical" apoptosis, and could be a promising new compound to overcome resistance to standard therapies in genitourinary malignancies.
Genetic control of quality melon traits

Field: Agricultural and Biological Sciences (Life Sciences)

ABSTRACT: This research studied the genetic control of the traits related to melon fruit quality. The F1, F2, BC1, BC2 generations from the OL x A-16 and OL x PV crossings were evaluated in two separate trials conducted in randomized blocks with three replications. The evaluated traits were: average fruit weight, shape index, pulp thickness, pulp firmness, soluble solids content and cracking rate. The analyses were accomplished through a classic study of generations involving mixed models. The parameters on heritability and number of loci controlling the traits were evaluated in a broad and narrow sense. The inheritance of the evaluated traits is complex, presenting one gene of greater effect and polygenes with additive and dominant effects.
215404 A framework for evaluating kansei quality of product texture considering with multi-modal sensations and action

Field: Engineering (Physical Sciences)

In the design of product texture, it is important for a designer to grasp the difference of user's affective characteristics between single-modal sensations and multi-modal one. Customers' emotional responses may differ depending on visual, touch and their combination. In this paper, we propose an evaluation framework to visualize the difference of kansei structure towards product texture between different modalities. In the method, we apply the simultaneous relationship analysis and ISM (Interpretive Structure Model) to structure words for evaluating texture's kansei. The framework considers actions for evaluating touch i.e. haptics and affordances towards texture. To demonstrate the effectiveness of the framework, we conducted a sensory evaluation experiment using plastic texture samples and cylindrical shapes having different textures as case studies.
www.neoplasia.com Multiple Stress Signals Induce p73B Accumulation 1

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Although p73 is a structural and functional homologue of the tumor-suppressor gene p53, it is not mutated in many human cancers as p53. Besides, p73 was shown to be activated by only a subset of signals that activate p53, such as g-irradiation and cisplatin, but not by other common genotoxic stress-inducing agents such as ultraviolet (UV) irradiation, although many of these signals are also capable of inducing p53-independent cell death. Using a p73-specific antibody, we confirmed that c-Abl is required for cisplatininduced p73 upregulation, and further demonstrate that the p73 protein is upregulated by UV irradiation and other stress stimuli including sorbitol, hydrogen peroxide, nocodazol, and taxol. These stress signals upregulate both p73 mRNA and increases the stability of p73, indicating that p73 is regulated transcriptionally and posttranslationally. Cells stably expressing the dominant-negative p73 inhibitor protein (p73DD) and p73 / fibroblasts are more resistant than control cells to apoptosis induced by these stress signals, suggesting that p73 contributes to apoptosis induction. Together, the data demonstrate that several stress signals can signal to p73 in vivo, which raises the possibility of eradicating cancers with an unmutated p73 gene by activating them with stress-inducing agents or their mimetics.
Potentiation of Bleomycin Lethality by Anticalmodulin Drugs: A Role for Calmodulin in DNA Repair

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Treatment of exponentially growing Chinese hamster ovary cells with bleomycin causes a dose-dependent decrease in cell survival due to DNA damage. This lethal effect can be potentiated by the addition of a nonlethal dose of the anticalmodulin drug N -(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide (W13) but not its inactive analog N -(4-aminobutyl)-2-naphthalenesulfonamide (W12). By preventing the repair of damaged DNA, W13 also inhibits recovery from potentially lethal damage induced by bleomycin. These data suggest a role for calmodulin in the DNA repair pathway.
COVID-19 and the rise of maternal deaths: evidence from Mexico

Field: Medicine (Health Sciences)

I use 2013–2020 state-month-year data from official maternal death records to quantify the effect of the pandemic on maternal deaths in Mexico. Using a Poisson count regression model that accounts for seasonal trends and unobserved differences across states, I show maternal deaths started increasing meaningfully in April-May 2020. More specifically, I find that the expected number of maternal deaths increased by a factor of 2 during May-August 2020. Moreover, this increase factor remained above 1.6 after September 2020, indicating that the effect of the pandemic on maternal deaths continued to be meaningful at the end of year. I also provide evidence of the key mechanism that could plausibly explain this increase: COVID-19 was the main underlying cause of 26.5% of maternal deaths in 2020. This accounts for nearly all of the increase in maternal deaths from 2019 to 2020.
TEACHING READING COMPREHENSION OF DESCRIPTIVE TEXT THROUGH PQRST TECHNIQUE BASED ON WHOLE LANGUAGE APPROACH

Field: Arts and Humanities (Social Sciences)

Abstract: Teaching reading is challenging for teacher because not all students can comprehend what they have read. This research is intended to answer the problem about how does PQRST technique based on Whole Language Approach improve students’ reading comprehension on descriptive text about animal. This research is classroom action research. Whole Language approach is a philosophy which focused on making meaning in reading. Then, the technique used to improve the students reading comprehension on finding out the detail information and understanding language feature on descriptive text was PQRST technique. This technique guided the students to comprehend the information of descriptive text about animal. The result of this research showed that the students reading comprehension on descriptive text improved after applied the PQRST technique. With this activity, students had more practice in reading. Besides, during the reading process students were active in asked and answered questions, this technique also guide students to summarize the information of the passage. Consequently, the technique successfully improved the students’ achievement in reading comprehension of descriptive text. Key words: Reading Comprehension, PQRST Technique, Whole Language Approach. Abstrak: Mengajar membaca adalah sesuatu yang menantang untuk guru karena tidak semua siswa dapat memahami apa yang mereka baca. Penelitian ini bertujuan untuk menjawab permasalahan bagaimana teknik PQRST berdasarkan pedekatan whole language meningkatkan pemahaman siswa dalam membaca teks deskripsi tentang hewan. Penelitian ini adalah penelitian tindakan kelas. Pendekatan Whole Language adalah sebuah pandangan yang menekankan pada pemahaman makna bacaaan. Kemudian, teknik yang digunakan untuk meningkatkan kemampuan pemahaman membaca dalam menemukan informasi terperinci dan memahami tata bahasa dalam bacaan deskripsi adalah teknik PQRST. Dengan teknik ini siswa dilatih untuk memahami isi bacaan deskripsi tentang hewan. Hasil penelitian menunjukan peningkatan pemahaman membaca bacaan deskripsi siswa setelah penerapan teknik PQRST. Melalui aktivitas ini siswa berlatih memahami bacaan, mengajukan dan menjawab pertanyaan, siswa juga dituntun untuk meringkas informasi dari bacaan. Hasilnya, kemampuan siswa memahami bacaan deskripsi juga meningkat. Kata Kunci: Pemahaman Membaca, Pendekatan Whole Language, Teknik PQRST.
Partially Stirred Reactor Model: Analytical Solutions and Numerical Convergence Study of a PDF/Monte Carlo Method

Field: Computer Science (Physical Sciences)

We investigate the partially stirred reactor (PaSR), which is based on a simplified joint composition probability density function (PDF) transport equation. Analytical solutions for the first four moments of the mass density function (MDF) obtained from the PaSR model are presented. The Monte Carlo particle method with first order time splitting algorithm is implemented to obtain the first four moments of the MDF numerically. The dynamics of the stochastic particle system is determined by inflow-outflow, chemical reaction, and mixing events. Three different inflow-outflow algorithms are investigated: an algorithm based on the inflow-outflow event modeled as a Poisson process, an inflow-outflow algorithm mentioned in the literature, and a novel algorithm derived on the basis of analytical solutions. It is demonstrated that the inflow-outflow algorithm used in the literature can be explained by considering a deterministic waiting time parameter of a corresponding stochastic process, and also forms a specific case of the new algorithm. The number of particles in the ensemble, N, the nondimensional time step, $\Delta t^{*}$ (ratio of the global time step to the characteristic time of an event), and the number of independent simulation trials, L, are the three sources of the numerical error. The split analytical solutions and the numerical experiments suggest that the systematic error converges as $\Delta t^{*}$ and N-1 . The statistical error scales as L-1/2 and N-1/2 . The significance of the numerical parameters and the inflow-outflow algorithms is also studied by applying the PaSR model to a practical case of premixed kerosene and air combustion.
PREVALENCE AND RISK FACTORS OF HELICOBACTER PYLORI AND INTESTINAL PROTOZOAL INFECTIONS AMONG SEWAGE WORKERS IN MANSOURA, EGYPT

Field: Medicine (Health Sciences)

Background:The occupational risks for sewage exposed workers for developing Helicobacter pylori and protozoal infections have received a little attention.Studies revealed that H. pylori organism discharged in stool and could be transmitted through contaminated water and consequently could present a significant health problem to sewage workers.Objective: to estimate the prevalence of H. pylori and protozoal infections and to assess the gastrointestinal symptoms and hematological profile among sewage workers.Also, to determine the risk factors of H. pylori infection.Methods: A comparative cross sectional study was conducted for 60 workers working in Mansoura sewage treatment plant and maintenance of sewage collection system and 30 matched unexposed referents working as food handlers and supervisors in Mansoura University Hospitals.Demographic, occupational and gastrointestinal symptoms data were collected.Also, laboratory procedures include, complete blood count, stool analysis and culture and detection of H. pylori antigen using immunochromatographic rapid assay were done. Results:The prevalence of H. pylori in sewage workers was 56.7% compared to 16.7% among the control group with highly statistically significant difference between both groups.Heartburn with or without epigastric pain was the only significant gastrointestinal symptoms among sewage workers (43.3%) compared to comparison group (20.0%).Prevalence of E. histolytica in both exposed and comparison groups were high (65%
From statistical non-significance to statistical equivalence: An alternative approach for whole effluent toxicity testing

Field: Decision Sciences (Social Sciences)

Short-term toxicity tests with aquatic organisms are a valuable measurement tool in the assessment of the toxicity of effluents, environmental samples and single chemicals. Currently toxicity tests are utilized in a wide range of US EPA regulatory activities including effluent discharge compliance. In the current approach for determining the No Observed Effect Concentration, an effluent concentration is presumed safe if there is no statistically significant difference in toxicant response versus control response. The conclusion of a safe concentration may be due to the fact that it truly is safe, or alternatively, that the ability of the statistical test to detect an effect, given its existence, is inadequate. Results of research of a new statistical approach, the basis of which is to move away from a demonstration of no difference to a demonstration of equivalence, will be discussed. The concept of observed confidence distributions, first suggested by Cox, is proposed as a measure of the strength of evidence for practically equivalent responses between a given effluent concentration and the control. The research included determination of intervals of practically equivalent responses as a function of the variability of control response. The approach is illustrated using reproductive data from tests with Ceriodaphnia dubiamore » and survival and growth data from tests with fathead minnow. The data are from the US EPA`s National Reference Toxicant Database.« less
Optimal control driven functional electrical stimulation: A scoping review

Field: Medicine (Health Sciences)

Introduction: Rehabilitation after a neurological impairment can be supported by functional electrical stimulation (FES). However, FES is limited by early muscle fatigue, slowing down the recovery progress. The use of optimal control to reduce overstimulation and improve motion precision is gaining interest. This review aims to map the current literature state meanwhile clarifying the best practices, identifying persistent challenges, and outlining directions for future research. Methods: Following the PRISMA guidelines, a search was conducted up to February 2024 using the combined keywords "FES", "optimal control" or "fatigue" across five databases (Medline, Embase, CINAHL Complete, Web of Science, and ProQuest Dissertations & Theses Citation Index). Inclusion criteria included the use of optimal control with FES for healthy individuals and those with neuromuscular disorders. Results: Among the 44 included studies, half were in silico and half in vivo, involving 87 participants, predominantly healthy young men. Twelve different motor tasks were investigated, with a focus on single joint lower limb movements. These studies principally used simple FES models, modulating pulse width or intensity to track joint angle. Conclusions: Optimal control-driven FES can deliver precise motions and reduce fatigue. Yet clinical adoption is slowed down by the lack of consensus about modelling, inconvenient model identification protocol and limited validation. Additional barriers include insufficient open-science practices, computational performance reporting and the availability of customizable commercial hardware. Comparative FES model studies and longitudinal trials with large cohorts, among other efforts, are required to improve the technology readiness level. Such advances would help clinical adoption and improve patient outcomes.
Grant Writing Handbook for Our Lady of Fatima Parish School

Field: Social Sciences (Social Sciences)

Grant Writing Handbook for Our Lady of Fatima Parish School By Tracy Severson This manual is an applied thesis written for Our Lady of Fatima Parish School, a small Catholic school located in Huntington, West Virginia. Its purpose is to introduce novice grant writers to the terms and processes associated with grant writing for this particular parochial school. The manual guides the fledgling writer through church and school history, ideas and strategies to develop the grant, grant writing and the post-submission process. Only examples from submitted church grants are referenced and all address Our Lady of Fatima needs and mission statement. The handbook is intended as a springboard for grant writing in the fledgling Development Committee, the fundraising arm of the church. As the writers and fundraisers become more sophisticated and experienced, the manual is expected to expand and change – reflecting growth and maturity. The Grant Writing Handbook for Our Lady of Fatima is a living document which will adapt to its
Historiography and Public History in Pennsylvania

Field: Arts and Humanities (Social Sciences)

Research Article| July 01 2008 Historiography and Public History in Pennsylvania Rosalind Remer Rosalind Remer Search for other works by this author on: This Site Google Pennsylvania History: A Journal of Mid-Atlantic Studies (2008) 75 (3): 422–427. https://doi.org/10.2307/27778848 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Rosalind Remer; Historiography and Public History in Pennsylvania. Pennsylvania History: A Journal of Mid-Atlantic Studies 1 July 2008; 75 (3): 422–427. doi: https://doi.org/10.2307/27778848 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectivePenn State University PressPennsylvania History: A Journal of Mid-Atlantic Studies Search Advanced Search The text of this article is only available as a PDF. Copyright © 2008 The Pennsylvania Historical Association2008The Pennsylvania Historical Association Article PDF first page preview Close Modal You do not currently have access to this content.
Management science application in tourism and hospitality

Field: Decision Sciences (Social Sciences)

* Preface (Zheng Gu) * A Multi-Criteria Approach to Destination Benchmarking: A Case Study of State Tourism Advertising Programs in the United States (Karl W. Wober and Daniel R. Fesenmaier) * An Exploratory Investigation of Multiunit Restaurant Productivity Assessment Using Data Envelopment Analysis (Dennis Reynolds) * Hotel Labor Productivity Assessment: A Data Envelopment Analysis (Bo A. Hu and Liping A. Cai) * Using Data Envelopment Analysis for Measuring and Benchmarking Productivity in the Hotel Sector (Marianna Sigala) * Modeling Tourism Demand: A Decision Rules Based Approach (Rob Law, Carey Goh, and Ray Pine) * Initially Testing an Improved Extrapolative Hotel Room Occupancy Rate Forecasting Technique (Rob Law) * Forecasting in Short-Term Planning and Management for a Casino Buffet Restaurant (Clark Hu, Ming Chen, and Shiang-Lih Chen McCain) * Applying City Perception Analysis (CPA) for Destination Positioning Decisions (Sara Dolnicar and Klaus Grabler) * Index * Reference Notes Included
1170.—Extracts from the annual Exchequer account for Gloucester, recording the sheriff’s payment of the annual sum due from the city of Gloucester, and payments by various burgesses apparently as penalties for forming a commune

Field: Arts and Humanities (Social Sciences)

"44 1170.—Extracts from the annual Exchequer account for Gloucester, recording the sheriff's payment of the annual sum due from the city of Gloucester, and payments by various burgesses apparently as penalties for forming a commune" published on 01 Jan 1988 by Brill.
An Archeological History of the Hocking Valley

Field: Arts and Humanities (Social Sciences)

The Hocking River stretches 95 miles south eastward from Columbus to the Ohio River, draining an area of 1,200 square miles. In this detailed study of the archeological investigations in the Hocking Valley, James L. Murphy summarizes and re-evaluates explorations in the light of current knowledge. He discusses the prehistory of the Hocking Valley for six major time periods: Paleo-Indian, Archaic, Early Woodland, Middle Woodland, Late Woodland, and Late Prehistoric. Never before available in paperback, this new edition also reveals Murphy s original findings during 15 years of archeological surveys and excavations. This book includes detailed reports on the excavation of three Adena mounds, two Fort Ancient village sites, and several multi-component rock shelters. A deliberate effort to present archeological finds of interest to both the professional archeologist and the layman in terms understandable to both has been coupled with an attempt to distinguish clearly between the presentation of facts and the presentation of opinion. The book is enhanced by illustrations of much of the artifact material analyzed in the text, site diagrams, and a map locating all major known archeological sites in the Hocking Valley, and an appendix locating and describing all sites discussed in the text.