jimnoneill/paper-to-field-training huggingface dataset:
Sosialisasi Bahaya Gadget (Handphone) Bagi Anak-Anak Di Desa Air Petai Kecamatan Sukaraja Kabupaten Seluma, Bengkulu

Field: Social Sciences (Social Sciences)

The use of information and communication technology in the world of education today is growing, one of them is the gadget (phone). Gadgets (phone) is one of the forms of information technology and communication that is constantly evolving from time to time. Excessive use of gadgets (mobiles) in children can have a negative impact on the growing children of primary school age, it does not exclude the possibility that will cause children to become personal closure due to the lack of social interaction. However, on the other hand, the use of information and communication technology is very beneficial for learning activities. In this case, it is necessary to have sufficient knowledge of the technology and how it is applied in everyday life. In this case, parental supervision is essential, because elementary school children usually have a high level of curiosity for new things.
Actin-binding peptides obtained from the C-terminal 24-kDa fragment of porcine aorta smooth muscle myosin subfragment-1 heavy chain.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The C-terminal 24-kDa fragment of myosin subfragment-1 (S-1) heavy chain was isolated by papain digestion of porcine aorta myosin followed by ethanol fractionation. The isolated 24-kDa fragment was digested by lysylendopeptidase. When the digest was ultracentrifuged with F-actin, 7- and 2-kDa peptides coprecipitated with the actin. These two peptides were isolated by high performance liquid chromatography, and their amino acid sequences were determined. The 7- and 2-kDa peptides correspond to residues 692-744 and 835-846, respectively, of the chicken gizzard myosin heavy chain (Yanagisawa, M., Hamada, Y., Katsuragawa, Y., Imamura, M., Mikawa, T., and Masaki, T. (1987) J. Mol. Biol. 198, 143-157). The 7-kDa peptide contains the reactive cysteine residues, SH1 and SH2. The isolated 7- and 2-kDa peptides also bound to F-actin with dissociation constants of 0.6 and 12 microM, respectively. The 2-kDa peptide was found to compete with rabbit skeletal S-1 for the binding to F-actin by examining the binding of S-1 to actin in the presence of various concentrations of the 2-kDa peptide. The 2-kDa peptide was also shown to interact with the regulatory light chain of aorta myosin by difference UV absorption spectroscopy. The 2-kDa peptide inhibited the actin-activated ATPase activity of skeletal S-1, and the inhibition was canceled by the addition of the isolated regulatory light chain. These results suggest that the newly found 2-kDa peptide region may be related to the regulation of smooth muscle actomyosin ATPase activity by phosphorylation of the regulatory light chain.
SAAT1 is a low affinity Na+/glucose cotransporter and not an amino acid transporter. A reinterpretation.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Recently a member of the Na+/glucose (SGLT1) gene family of cotransporters was isolated from a pig renal cell line and was thought to be the neutral amino acid transporter System A. This cDNA (Kong, C. T., Yet, S. F., and Lever, J. E. (1993) J. Biol. Chem. 268, 1509-1512) encodes a 660-amino acid protein with 76% identity to SGLT1. To confirm and extend the kinetic characterization of SAAT1, we have expressed this clone in Xenopus oocytes and measured transport using both radiotracer and electrophysiological techniques. SAAT1 did not stimulate either 50 microM 2-(methylamino)isobutyrate uptake or 2-(methylamino)isobutyrate-evoked inward Na+ currents, but instead stimulated 50 microM alpha MG (alpha-methyl-D-glucopyranoside) uptake 27-fold from 2 +/- 1 pmol.h-1/oocyte (n = 9) to 55 +/- 6 pmol.h-1/oocyte (n = 9) and alpha MG-evoked inward Na+ currents (I) by up to 1000 nA/oocyte. The apparent affinity constant for alpha MG (K alpha MG 0.5) was approximately 2 mM and was independent of membrane potential from -30 to -150 mV but was voltage-sensitive between -30 and +30 mV. The relative sugar specificity for the transporter was alpha MG > or = D-glucose >> D-galactose >>> 3-O-methyl-D-glucopyranose, L-glucose. The sugar-evoked currents were Na(+)-dependent (KNa 0.5 approximately 10 mM at -50 mV) and the Hill coefficient was 1. KNa 0.5 decreased with hyperpolarization of the membrane from -50 to -150 mV. Phlorizin inhibited the alpha MG-evoked current with apparent Ki of 18 microM at -50 mV. We conclude that the SAAT1 cDNA encodes a renal low affinity Na+(1)/glucose(1) cotransporter and propose that pig SAAT1 be renamed pSGLT2.
Investigating the Spatial Heterogeneity of Urban Heat Island Responses to Climate Change Based on Local Climate Zones

Field: Environmental Science (Physical Sciences)

Global warming and the urban heat island (UHI) phenomenon have significant impacts on human activities, against which it is necessary to develop effective coping strategies. Based on the local climate zone (LCZ) system, this study used the land-cover and surface temperature data on the Chang–Zhu–Tan (CZT) urban agglomeration in China in 2006, 2010, 2016, and 2020 to analyze the impact of climate change on the land surface temperature (LST) under different land-cover types. The results illustrate that the LCZ map generated on the basis of the improved World Urban Database and Access Portal Tools (WUDAPT) is more accurate and efficient than the traditional method. The accuracy is increased by more than 15%. From 2006 to 2020, the main built-up types in the CZT urban agglomeration were the sparsely built, the large low-rise, and the compact mid-rise types. The low-plant type represents the most significant proportion of the natural types, followed by the water and the dense-tree types. The built-up types in the CZT urban agglomeration tend to be the high-rise, dense, and industrial types. Urban construction land is taken mainly from the sparsely built type of land. The average LST of the large low-rise and heavy-industry zones is significantly higher than the average LST of the three cities. The average LST values for the water and dense-tree zones are significantly lower than the other average LST values. The LST is stable in each LCZ, showing little correlation with the size of the LCZ area. Compact low-rise land use is ineffective against climate warming and inhibits economic growth. Compact high-rise and open high-rise land can not only effectively deal with climate warming but can also significantly stimulate economic growth. This paper helps us to understand the effect of land cover on climate warming and the economic benefits of LCZs in the CZT urban agglomeration and provides strategies to optimize the use of land resources.
Studies on Pigment Migration in the Melanophores of the Teleost <i>Fundulus heteroclitus</i> (L)

Field: Agricultural and Biological Sciences (Life Sciences)

Observations made which coupled physiological and histochemical methods with a morphological analysis of the process of pigment migration in the melanophores of Fundulus heteroclitus suggest the following conclusions:1. The main source of energy for this activity probably derives from oxidative phosphorylation.2. Pigment migration seems to be sodium-dependent but is not influenced by external calcium ions.3. These cells present a complex system of microtubules that limit the paths through which the pigment granules migrate.4. Evidence is presented linking pigment granule transport to microtubles.5. A histochemical method failed to reveal the existence of cholinergic nerve endings in the melanophore.6. A critical review is made of the hypothesis proposed to explain pigment migration.
Mass Conserving Mixed $hp$-FEM Approximations to Stokes Flow. Part II: Optimal Convergence

Field: Mathematics (Physical Sciences)

Related DatabasesWeb of Science You must be logged in with an active subscription to view this.Article DataHistorySubmitted: 10 August 2020Accepted: 16 February 2021Published online: 11 May 2021Keywordsmixed finite element, incompressible flow, divergence free, approximation theory, $hp$-finite elementAMS Subject Headings76M10, 65N30, 65N12Publication DataISSN (print): 0036-1429ISSN (online): 1095-7170Publisher: Society for Industrial and Applied MathematicsCODEN: sjnaam
Effect of <i>sac</i> mutations on the <i>SAC51</i> 5’-<i>GUS</i> expression.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p><b>(A)</b> Effect of <i>sac</i> mutations on <i>SAC51</i> expression. Relative mRNA levels of <i>SAC51</i> in 10-day-old seedlings were examined as shown in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0117309#pone.0117309.g005" target="_blank">Fig. 5</a> caption. An asterisk indicates a significant difference (P < 0.05) from the wild type (L<i>er</i>). <b>(B)</b> Effect of thermospermine on CaMV 35S promoter-driven <i>SAC51</i> 5’-<i>GUS</i> expression. Seedlings carrying the <i>SAC51</i> 5’ leader-<i>GUS</i> gene fused with the CaMV 35S promoter were grown for 10 days in MS agar plates and incubated for 24 h in MS solutions without (black bars) or with 100 μM thermospermine (white bars). Data show means ± SD (n = 3). Significant difference (P < 0.05) from the wild type (L<i>er</i>) is indicated by different lowercase letters. <b>(C)</b> to <b>(G)</b> GUS staining of wild-type <b>(C)</b>, <i>acl5–1</i><b>(D)</b>, <i>acl5–1 sac52-d</i><b>(E)</b>, <i>acl5–1 sac53-d</i><b>(F)</b>, and <i>acl5–1 sac56-d</i><b>(G)</b> seedlings carrying the <i>SAC51</i> 5’ leader-<i>GUS</i> gene fused with the CaMV 35S promoter. Seedlings were grown for 3 days in MS agar plates.</p>
Noninvasive prenatal detection of Down syndrome: are we finally getting the right message?

Field: Medicine (Health Sciences)

Evaluation of: Lo YM, Tsui NB, Chiu RW et al. Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection. Nat. Med. 13, 218–223 (2007).A recent report by Dennis Lo and colleagues has indicated that the analysis of placentally derived cell-free mRNA can be used to detect fetal Down syndrome. The unique aspect of this work is that fetal ploidy for chromosome 21 was determined by a quantitative assessment of gene expression for a chromosome 21-specific gene, namely PLAC4. This technical feat was achieved by quantifying the relative expression of PLAC4 alleles to each other by the mass spectrometric analysis of single nucleotide polymorphism loci. By these means, fetal trisomy 21 could be detected noninvasively with a sensitivity of 90% for a false-positive rate of less than 3.5%. Hence, it is highly probable that this salient development could usher in a new era in noninvasive prenatal diagnosis.
Parametric excitation of electrostatic whistler wave and electron Bernstein wave by extraordinary EM wave

Field: Physics and Astronomy (Physical Sciences)

In the present paper, the parametric decay instability of an extraordinary electromagnetic wave (X-wave) into an electron Bernstein wave (EBW) and an electrostatic whistler wave (W-wave) has been studied. Expressions are derived for homogeneous threshold, growth rate, and convective threshold for this instability. The relevance of the present parametric process has been pointed out to explain the generation of whistler mode radiations in the SL-2 experiment, ionospheric modification experiment, in the polar cusp region of the magnetosphere, as well as during intense electron cyclotron resonance heating in the MTX tokamak.
Suitability of the Forced Oscillation Technique for Measuring Bronchoconstriction in Pharmacological Studies

Field: Medicine (Health Sciences)

Conference Abstract| January 01 1985 Suitability of the Forced Oscillation Technique for Measuring Bronchoconstriction in Pharmacological Studies R.N. Davidson; R.N. Davidson 1Department of Medicine I, St. George's Hospital Medical School, London, SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar A. Allistone; A. Allistone 1Department of Medicine I, St. George's Hospital Medical School, London, SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar J.C. Pounsford; J.C. Pounsford 1Department of Medicine I, St. George's Hospital Medical School, London, SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar K.B. Saunders K.B. Saunders 1Department of Medicine I, St. George's Hospital Medical School, London, SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1985) 68 (s11): 4P. https://doi.org/10.1042/cs068004Pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation R.N. Davidson, A. Allistone, J.C. Pounsford, K.B. Saunders; Suitability of the Forced Oscillation Technique for Measuring Bronchoconstriction in Pharmacological Studies. Clin Sci (Lond) 1 January 1985; 68 (s11): 4P. doi: https://doi.org/10.1042/cs068004Pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1985 The Biochemical Society and the Medical Research Society1985 Article PDF first page preview Close Modal You do not currently have access to this content.
In vivo and vitro studies on formation of bile acids in patients with Zellweger syndrome. Evidence that peroxisomes are of importance in the normal biosynthesis of both cholic and chenodeoxycholic acid.

Field: Medicine (Health Sciences)

The last step in bile acid formation involves conversion of 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid (THCA) into cholic acid and 3 alpha,7 alpha-dihydroxy-5 beta-cholestanoic acid (DHCA) into chenodeoxycholic acid. The peroxisomal fraction of rat and human liver has the highest capacity to catalyze these reactions. Infants with Zellweger syndrome lack liver peroxisomes, and accumulate 5 beta-cholestanoic acids in bile and serum. We recently showed that such an infant had reduced capacity to convert a cholic acid precursor, 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol into cholic acid. 7 alpha-Hydroxy-4-cholesten-3-one is a common precursor for both cholic acid and chenodeoxycholic acid. Intravenous administration of [3H]7 alpha-hydroxy-4-cholesten-3-one to an infant with Zellweger syndrome led to a rapid incorporation of 3H into biliary THCA but only 10% of 3H was incorporated into cholic acid after 48 h. The incorporation of 3H into DHCA was only 25% of that into THCA and the incorporation into chenodeoxycholic acid approximately 50% of that in cholic acid. The conversion of intravenously administered [3H]THCA into cholic acid in another infant with Zellweger syndrome was only 7%. There was a slow conversion of THCA into 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-C29-dicarboxylic acid. The pool size of both cholic- and chenodeoxycholic acid was markedly reduced. Preparations of liver from two patients with Zellweger syndrome had no capacity to catalyze conversion of THCA into cholic acid. There was, however, a small conversion of DHCA into chenodeoxycholic acid and into THCA. It is concluded that liver peroxisomes are important both for the conversion of THCA into cholic acid and DHCA into chenodeoxycholic acid.
Identification and Characterization of Thiosemicarbazones with Antifungal and Antitumor Effects: Cellular Iron Chelation Mediating Cytotoxic Activity

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Thiosemicarbazones derived from acetylpyrazines were prepared by condensing an acetylpyrazine or a ring-substituted acetylpyrazine with thiosemicarbazide. Using the same procedure, N, N-dimethylthiosemicarbazones were synthesized from acetylpyrazines and N, N-dimethylthiosemicarbazide. A total of 20 compounds (16 novel) were chemically characterized and then tested for antifungal effects on eight strains of fungi and also for antitumor activity against SK-N-MC neuroepithelioma cells. The most effective compound identified in terms of both antifungal and antitumor activity was N, N-dimethyl-2-(1-pyrazin-2-ylethylidene)hydrazinecarbothioamide (5a). The mechanism of action of this and its related thiosemicarbazones was due, at least in part, to its ability to act as a tridentate ligand that binds metal ions. This was deduced from preparation of the related thiosemicarbazones [acetophenone thiosemicarbazone (6) and acetophenone N, N-dimethylthiosemicarbazone (7)] that do not possess a coordinating ring-N, which plays a vital role in metal ion chelation. Furthermore, 5a and several other thiosemicarbazones that showed high antiproliferative activity were demonstrated to have marked iron (Fe) chelation efficacy. In fact, these agents were highly effective at mobilizing (59)Fe from prelabeled SK-N-MC cells and preventing (59)Fe uptake from the serum Fe transport protein, transferrin. In contrast, compounds 6 and 7 that do not possess a tridentate metal-binding site showed little activity. Further studies examining ascorbate oxidation demonstrated that the Fe complexes of the most effective compounds were redox-inactive. Thus, in contrast to other thiosemicarbazones with potent antiproliferative activity, Fe chelation and mobilization rather than free radical generation played a significant role in the cytotoxic effects of the current ligands.
["Through the Eyes of Ossie Davis" KERA interview]

Field: Arts and Humanities (Social Sciences)

Video footage from The Black Academy of Arts and Letters recorded during a KERA interview broadcast with actor, director, writer and activist Ossie Davis on June 12th, 1980. The VHS footage shows Davis speaking on his experiences as a black poet in the arts and elaborates on his writing process. The interview covers a wide variety of topics.
Golgi protein localisation in Schizosaccharomyces pombe

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The aim of the research was to identify Golgi targeting motifs in the galactosyltransferase Gma12p in Schizosaccharomyces pombe. For this study it was tagged at its C-terminal end with the Green Fluorescent Protein (GFP) allowing mutations that cause fusion protein mislocalisation to be easily identified by confocal microscopy. All regions of the enzyme were studied for a possible role in localisation. Deletion analysis was carried out on the lumenal domain. This showed that the catalytic domain was not required for correct Golgi localisation. Deletion of parts of the stem region then showed that at least seventy three amino acids from this region were required. The role of the TMD was also explored. Initially it was investigated what other TMDs could substitute for that of Gmal2p and still confer Golgi localisation. Therefore, the TMD was swapped with those of three homologues of Gma12p, Gth1p, Gth3p, Gth5p. All three conferred Golgi localisation as measured by fluorescent microscopy. However, these four TMDs show little sequence homology and vary in length from approximately 22 to 28 residues. Therefore the TMD was specifically altered in length by the addition or deletion of three hydrophobic residues. The lengthening of the TMD by three residues caused substantial mislocalisation of the fusion protein. This mislocalisation was also seen when either or both of two threonine residues within the TMD were replaced with leucine. These mutant fusion proteins were localised to an endoplasmic reticulum (ER) compartment as shown by colocalisation with the ER chaperone BiP. The fusion proteins were shown to be folding correctly, making it unlikely that they are retained in the ER by quality control. Therefore, I propose that the two threonines in the TMD mediate a protein protein interaction that is required for efficient transport of Gma12p from the ER to the Golgi apparatus.
Structural Supervision for Word Alignment and Machine Translation

Field: Computer Science (Physical Sciences)

Syntactic structure has long been argued to be potentially useful for enforcing accurate word alignment and improving generalization performance of machine translation. Unfortunately, existing wisdom demonstrates its significance by considering only the syntactic structure of source tokens, neglecting the rich structural information from target tokens and the structural similarity between the source and target sentences. In this work, we propose to incorporate the syntactic structure of both source and target tokens into the encoder-decoder framework, tightly correlating the internal logic of word alignment and machine translation for multi-task learning. Particularly, we won’t leverage any annotated syntactic graph of the target side during training, so we introduce Dynamic Graph Convolution Networks (DGCN) on observed target tokens to sequentially and simultaneously generate the target tokens and the corresponding syntactic graphs, and further guide the word alignment. On this basis, Hierarchical Graph Random Walks (HGRW) are performed on the syntactic graphs of both source and target sides, for incorporating structured constraints on machine translation outputs. Experiments on four publicly available language pairs verify that our method is highly effective in capturing syntactic structure in different languages, consistently outperforming baselines in alignment accuracy and demonstrating promising results in translation quality.
Bulk-edge correspondence of Stiefel-Whitney and Euler insulators through the entanglement spectrum and cutting procedure

Field: Physics and Astronomy (Physical Sciences)

We propose an unconventional bulk-edge correspondence for two-dimensional Stiefel-Whitney insulators and Euler insulators, which are topological insulators protected by the $PT$ symmetry. We find that, although the energy spectrum under the open boundary condition is generally gapped, the entanglement spectrum is gapless when the Stiefel-Whitney or Euler class is nonzero. The robustness of the gapless spectrum for Stiefel-Whitney insulator can be understood through an emergent anti-unitary particle-hole symmetry. For the Euler insulators, we propose a conjecture, which is supported by our numerical calculation, that the Euler class is equal to the number of crossing in the entanglement spectrum, taking into account the degree of the crossings. We also discuss that these crossings of the entanglement spectrum are related to the gap closing points in the cutting procedure, which is the energy spectrum as the magnitude of the boundary hopping is varied.