Associated risks posed to healthcare workers when intubating the trachea of patients with COVID‐19: a reply

Field: Medicine (Health Sciences)

We thank Drs Begley and Brazil [1] for their interest in our study in which we report the risks of nosocomial infection to healthcare workers following their involvement in tracheal intubation of patients with COVID-19 [2]. They correctly point out that our findings reflect the potential impact to the hospital workforce and that we do not claim that the tracheal intubation episodes reported cause approximately 10% nosocomial infection to clinicians. We do, however, state that approximately 1 out of 10 healthcare workers involved in tracheal intubations went on to report a COVID-19 outcome (the primary endpoint of the study). In our study, we have reported an association, not causality, and we thank Drs Begley and Brazil for reinforcing this important difference. We wish to respond to some important points raised by Drs Begley and Brazil. Firstly, they state that if the virus was contracted during tracheal intubation, then a peak onset at around day 5 after exposure would have been seen in the cumulative plot. This was not evident on that graph due to the time variable intervals. However, in the daily risks data from our study, there is a visible upward deflection of the curve with time (Fig. 1), reflecting a non-linear increase over time, which could demonstrate a potentially increased risk associated with the procedure. Secondly, they state that there was no increased risk associated with the absence of personal protective equipment (PPE). While it is concerning that approximately 12% of tracheal intubations were performed with insufficient PPE utilisation and that our data analysis did not find any association between appropriate PPE utilisation and the primary endpoint, this does not definitively mean that there is no increased risk associated with inadequate PPE usage. Our study may have been underpowered to detect this association, and thus further work is required. As the adage goes, absence of evidence is not evidence of absence. Finally, Drs Begley and Brazil state that one would expect the number of tracheal intubations performed to be associated with the primary outcome if the risk of contracting the virus was associated with tracheal intubation procedures. This lack of association could be attributed to the increased experience, understanding and skills developed by the intubation teams with each subsequent tracheal intubation episode, improvement in the appropriate use and availability of suitable PPE, as well as the increasing availability of tracheal intubation guidelines during the pandemic [3]. To determine the extent to which performing tracheal intubation directly exposes healthcare workers to the risk of contracting COVID-19, staff isolation, serial testing and immunophenotyping of staff and their respective patients would be required which will ensure both validity and accuracy of any association. This challenging study could be considered for future research to provide us with a definitive answer, but in the absence of such data, large-scale studies such as the intubateCOVID project represent the highest level of evidence in the COVID-19 pandemic to date.