jimnoneill/paper-to-field-training huggingface dataset:
Problems in the prenatal diagnosis of Duchenne muscular dystrophy

Field: Medicine (Health Sciences)

Conference Article| June 01 1984 Problems in the prenatal diagnosis of Duchenne muscular dystrophy DAVID C. WATTS DAVID C. WATTS 1Biochemistry Department, Guy's Hospital Medical School, St Thomas' Street, London SE1 9RT, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1984) 12 (3): 366–368. https://doi.org/10.1042/bst0120366 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation DAVID C. WATTS; Problems in the prenatal diagnosis of Duchenne muscular dystrophy. Biochem Soc Trans 1 June 1984; 12 (3): 366–368. doi: https://doi.org/10.1042/bst0120366 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: CA, carbonic anhydrase, CK, creatine kinase, DMD, Duchenne muscular dystrophy This content is only available as a PDF. © 1984 Biochemical Society1984 Article PDF first page preview Close Modal You do not currently have access to this content.
The Clinical Observation of Closed Treating Lumbar Gluteal Fasciitis with XiaoHuoLuo Pills and Diprospan

Field: Medicine (Health Sciences)

Objective:To explore the effective methods of treating and preventing lumbar gluteal fasciitis.Methods: 118 patients were randomly divided into 3 groups,A group has 39 patients,diprospan partially closed group;B group has 40 patients,the group of XiaoHuoLuo pills;C group has 39 patients,the group combined diprospan partially closed and diprospan,a total of 118 cases observed in each group in alleviating the clinical efficiency of lumbar gluteal fasciitis and affecting its recurrence rate.Results:C was better than A、B group in clinical remission,the cure rate,efficiency and recurrence rate(P0.05),while the B group and C group showed no significant difference(P0.05).Conclusion:Closed treating lumbar gluteal fasciitis with XiaoHuoLuo pills and diprospan was effective,convenient,it had positive clinical efficiency in clinical remission,the cure rate,efficiency rate,especially in recurrence rate,and is worthy of promotion.
Motivational intermediaries of self-regulation among university students

Field: Psychology (Social Sciences)

Purpose The concept of self-regulated learning (SRL) has become increasingly important in higher educational institutes seeking to provide students with a holistic education. It is important for students entering, and faculty within higher education, to understand whether future time perspective (FTP) or self-efficacy is more predictive of self-regulation. The paper aims to discuss these issues. Design/methodology/approach Through the use convenience sampling, data were collected via an online survey from 130 undergraduate students attending universities in the United Arab Emirates (UAE). Data were analysed using regression analysis and inferential measures identifying themes in participants study habits in order to examine whether it is FTP or self-efficacy that more strongly predicts SRL behaviours. Findings Results suggest that self-efficacy is a much stronger predictor of SRL in undergraduate students than goal setting, as measured by FTP. Student’s most deficient SRL behaviours related to reading and comprehension of texts prescribed across modules. Research limitations/implications Due to the fact that only an adjusted 33 per cent of self-regulation was predicted by the two variables under consideration, researchers are encouraged to identify further variables that may predict students SRL. Practical implications This paper seeks to support both students and faculty in how to draw on SRL in order to optimize students’ success in higher education. Originality/value The current research supports the identification of learning behaviours specific to branch campuses in a Middle-Eastern context.
Luxembourg’s free public transport sounds great. It isn't

Field: Social Sciences (Social Sciences)

This is a reproduction of Carr/Hesse's 2019 "Luxembourg’s free public transport sounds great, but it won’t help people get from A to B" published Jan 16, 2019, in The Conversation. Available at:https://theconversation.com/luxembourgs-free-public-transport-sounds-great-but-it-wont-help-people-get-from-a-to-b-109695
Vitamin D: Moving Forward to Address Emerging Science

Field: Medicine (Health Sciences)

The science surrounding vitamin D presents both challenges and opportunities. Although many uncertainties are associated with the understandings concerning vitamin D, including its physiological function, the effects of excessive intake, and its role in health, it is at the same time a major interest in the research and health communities. The approach to evaluating and interpreting the available evidence about vitamin D should be founded on the quality of the data and on the conclusions that take into account the totality of the evidence. In addition, these activities can be used to identify critical data gaps and to help structure future research. The Office of Dietary Supplements (ODS) at the National Institutes of Health has as part of its mission the goal of supporting research and dialogues for topics with uncertain data, including vitamin D. This review considers vitamin D in the context of systematically addressing the uncertainty and in identifying research needs through the filter of the work of ODS. The focus includes the role of systematic reviews, activities that encompass considerations of the totality of the evidence, and collaborative activities to clarify unknowns or to fix methodological problems, as well as a case study using the relationship between cancer and vitamin D.
Gametophytic expression of GUS activity controlled by the potato Lhca3.St.1 promoter in tobacco pollen

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

A µ-glucuronidase (GUS) gene fusion with the promoter from the potato Lhca3.St.1 gene, encoding a light-harvesting complex protein, shows expression in pollen of transgenic tobacco plants. This was established by histochemical and fluorometric assays, and confirmed by RT-PCR, Western analysis and GUS activity following gel electrophoresis. The activity is minimal in early pollen development and high in mature pollen at anthesis. It shows gametophytic segregation in pollen grains. Pollen from tobacco plants hemizygous for a single Lhca3.St.1-GUS locus exhibited 151 segregation ratios, whereas dihybrids segregated in the expected 351 ratio. A sequential combination of histochemical staining for GUS activity and Alexander's stain for pollen viability, offers a convenient system to eliminate artefacts in the histochemical staining, identify inviable pollen and accurately score pollen segregation. The dual staining approach also confirmed gametophytic segregation in tobacco plants hemizygous for the GUS gene under transcriptional control of a doubled CaMV 35S promoter. Gametophytic segregation establishes that the GUS activity is determined by the genetic status of the pollen rather than of the parent plant, and indicates de novo GUS gene expression and translation during pollen maturation. The unanticipated activity of the Lhca3.St.1 promoter in pollen has implications for the biosafety assessment of transgenic plants intended for agricultural use. Even when a promoter is not generally considered to be active in pollen, its expression in pollen should be evaluated if effects on pollinating insects or food safety concerns for products such as honey can be anticipated.
Geoarchaeology of Wwii Aircraft in New Mexico, USA

Field: Earth and Planetary Sciences (Physical Sciences)

Before 1941 there were only a handful of fatal aircraft crashes in New Mexico every year.During World War II (WWII) more than 7,100 fatal air crashes involving United States Army Air Force (USAAF) aircraft occurred on American soil.Collectively these crashes resulted in the loss of over 15,500 lives.The majority of these crashes involved training flights.In New Mexico there were three locations for the Second Air Force -Alamogordo, Clovis and Kirtland Field -and five for the Army Air Forces Training Command -Carlsbad, Deming, Fort Sumner, Hobbs and Roswell.As a result of ramped up training, air crashes in New Mexico rose from about 10 in 1941 to over 450 in 1944.A large number of largely non-fatal crashes occurred in the vicinity of airfields, such as 115 from 1942-1945 around Alamogordo Army Air Field.A number of crashes occurred in mountainous terrane throughout New Mexico.For example, on April 22 nd 1942 a B-24D Liberator (four engine bomber) hit Trail Peak near Cimarron within what is now the Philmont Scout Ranch.Later that year on October 15th a B-17E Flying Fortress, another four engine bomber, struck North Baldy Peak near Magdalena.Other impacts occurred in a wide range of environments.A USAAF Consolidated 0A-10 (Army designation for Navy PBY-5A Catalina flying boat) crashed in what is now El Malpais National Monument on August 1 st , 1945.The aircraft crashed after having feathered one propeller (indicating an engine failure).A smaller number of aircraft disintegrated at altitude including a B-17F east of Medio on January 1 st , 1943 and a B-17E on August 23 rd 1942 near Las Cruces.Mid-air collisions were not uncommon in training such as one between a Cessna AT-17 and an AT-17B on January 10 th 1943 near Roswell.Geologic factors influence not only the location of many crash sites but also their preservational potential.The large number of WWII crashes in New Mexico provide potential for a significant geoarcheological dataset in aviation archeology.
Tertiary structural analysis of Escherichia coli lysine tRNA.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

It has been suggested that Escherichia coli lysine tRNA (E. coli tRNA(Lys)) has an unusual anticodon loop structure, judging from the abnormal CD pattern derived from 5-methylaminomethyl-2-thiouridine (mnm5s2U) located at the first position of the anticodon of the tRNA. Here, the structure of E. coli tRNA(Lys) was analysed by chemical modification and nuclear magnetic resonance (NMR) of the imino protons. The chemical probing approach showed that the anticodon arm region forms the ordinary stem-and-loop structure as expected from the standard clover-leaf structure, because N7 of G30, N3 of C40, N7 of A41 and N7 of A42 were protected under a native condition. By using the heteronuclear 15N-1H single quantum coherence (HSQC) spectra of 15N-labeled E.coli tRNA(Lys) and the analyses of the nuclear Overhauser effects (NOE) between the imino protons of non labeled E.coli tRNA(Lys), the imino protons in the acceptor stem was assigned, which indicates that the acceptor stem exists in an usual form. The tertiary base-base interactions was also detected. Thus, E.coli tRNA(Lys) seems to maintain a similar structure to the ordinary L-shaped tertiary structure, as a whole. The fine structure of the anticodon loop is now being analyzed.
Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Gating of the CFTR Cl− channel is associated with ATP hydrolysis at the nucleotide-binding domains (NBD1, NBD2) and requires PKA (protein kinase A) phosphorylation of the R domain. The manner in which the NBD1, NBD2 and R domains of CFTR (cystic fibrosis transmembrane conductance regulator) interact to achieve a properly regulated ion channel is largely unknown. In this study we used bacterially expressed recombinant proteins to examine interactions between these soluble domains of CFTR in vitro. PKA phosphorylated a fusion protein containing NBD1 and R (NBD1–R–GST) on CFTR residues Ser-660, Ser-700, Ser-712, Ser-737, Ser-768, Ser-795 and Ser-813. Phosphorylation of these serine residues regulated ATP hydrolysis by NBD1–R–GST by increasing the apparent Km for ATP (from 70 to 250 µM) and the Hill coefficient (from 1 to 1.7) without changing the Vmax. When fusion proteins were photolabelled with 8-azido-[α-32P]ATP, PKA phosphorylation increased the apparent kd for nucleotide binding and it caused binding to become co-operative. PKA phosphorylation also resulted in dimerization of NBD1–R–GST but not of R–GST, a related fusion protein lacking the NBD1 domain. Finally, an MBP (maltose-binding protein) fusion protein containing the NBD2 domain (NBD2–MBP) associated with and regulated the ATPase activity of PKA-phosphorylated NBD1–R–GST. Thus when the R domain in NBD1–R–GST is phosphorylated by PKA, ATP binding and hydrolysis becomes co-operative and NBD dimerization occurs. These findings suggest that during the activation of native CFTR, phosphorylation of the R domain by PKA can control the ability of the NBD1 domain to hydrolyse ATP and to interact with other NBD domains.
Biomimetic Activation of N‐Nitrosamides with Red Light‐Triggered Nitric Oxide Release via Mediated Electron Transfer

Field: Chemistry (Physical Sciences)

Abstract Mediated electron transfer (MET) is fundamental to many biological functions, including cellular respiration, photosynthesis, and enzymatic catalysis. However, leveraging the MET process to enable the release of therapeutic gases has been largely unexplored. Herein, we report the bio‐inspired activation of a series of UV‐absorbing N ‐nitrosamide derivatives (NOA) under red light exposure, enabling the quantitative release of nitric oxide (NO) gasotransmitter via an MET process. The cornerstone of our design is the covalent linkage of a 2,4‐dinitroaniline moiety, which acts as an electron mediator to the N ‐nitrosamide groups. This facilitates efficient electron transfer from the excited palladium(II) meso ‐tetraphenyltetrabenzoporphyrin (PdTPTBP) photocatalyst and the selective activation of NOA. Our approach has been validated with distinct photocatalysts and various N ‐nitrosamides, including those derived from carbamates, amides, and ureas. Notably, the modulation of the linker length between the electron mediator and N ‐nitrosamide groups serves as a regulatory mechanism for controlling NO release kinetics. Moreover, this biomimetic NO release platform demonstrates effective operation under both normoxic and hypoxic conditions, and it enables localized delivery of NO under physiological conditions, exhibiting significant anticancer efficacy within the phototherapeutic window and enhanced selectivity towards tumor cells.
Stability of Primary School Value-Added Scores over Time: A Comparison Between Math and Language Achievement as Outcome Variables

Field: Social Sciences (Social Sciences)

Value-added (VA) models are widely used for accountability purposes in education. Tracking a teacher’s or a school’s VA score over time forms oftentimes the basis for high-stakes decision-making and can determine whether teachers can keep their jobs or schools may receive certain funding. Despite their high-stakes application, the stability of VA scores over time has not yet been investigated for primary schools. Moreover, it is unclear whether different outcome measures (e.g., language and mathematics) may differ in their stability over time. In the present study, we aimed to clarify the stability of VA scores over time and investigate the differences across outcome variables. Furthermore, we wanted to showcase the real-life implications of (in)stable VA scores for single schools, with a focus on an informative use of VA scores rather than an evaluative way. The exploration of school VA scores in primary schools is especially relevant for heterogeneous student populations, for instance, in Luxembourg. Thus, we drew on representative longitudinal data from the standardized achievement tests of the Luxembourg School Monitoring Programme and examined the stability of school VA scores over two years in 146 schools (N = 7016 students). The overall stability, as measured by correlation coefficients, was moderate with r = .37 for VA scores in language and r = .34 for VA scores in mathematics from grade one to grade three. Real-life implications for schools will be discussed.
Comprehensive Evaluation of Eco-environmental Vulnerability in Rocky Desertification Region

Field: Environmental Science (Physical Sciences)

Combined with GIS and remote sensing technology, according to the eco-environment characteristics of karst rocky desertification region, a complete ecological vulnerability evaluation index system was established. The ecological vulnerability of the research area was evaluated and analysed from three aspects, including natural environment background, population characteristics, human-land relationship, and the index weight was determined by entropy method and coefficient of variation method, and the comprehensive evaluation results were obtained by comprehensive index method. The results showed that more than 80% of the regions in the study area had reached the moderate vulnerability level, and nearly 1/6 of the regions were severely vulnerable areas, showing a significant increase in distribution from east to west. Ecological vulnerability shows a significant effect of human-land relationship. With the increase of vulnerability level, the proportion of desertification area increases significantly.
Anomalies-Rich Floquet superconductivities induced by joint modulation of dynamic driving and static parameters

Field: Physics and Astronomy (Physical Sciences)

Abstract Current theoretical and experimental endeavors to realize an anomalous Floquet chiral topological superconductor (TSC), which is characterized by chiral Majorana edge modes independent of the Chern number, remain insufficient. Herein, we propose a new scheme that involves jointly tuning dynamic driving and static parameters within a magnetic topological insulator-superconductor sandwich structure to achieve this goal. The Josephson phase modulation induced by an applied bias voltage across the structure is utilized as a Floquet periodic drive. It is found that the interplay between the two kinds of tunings can bring about a lot more exotic Floquet TSC phases than those caused by only tuning the dynamic driving parameter (frequency ω or period τ ). More importantly, just tuning static parameters (the chemical potential µ , Zeeman field g z , and proximity-induced superconducting energy gap Δ b ) also can induce a series of novel topological phase transitions. Particularly, the features in the context of the three tunings are different from each other, originating from the combination of intrinsic and different extrinsic mechanisms. In addition, jointly tuning τ and µ ( g z ) can have its own unique TSC phases. The proposed scheme should be readily accessible in experiments, and thus the family of anomalous Floquet TSC phases may be considerably enriched.
A Study on the Regional SAFETY Status in Gangwon-Do Injury Prevention

Field: Health Professions (Health Sciences)

Purpose: Recently Safety Promotion Policies and Programs at the local government level have been spreading around the world. However, In order for these policies to work, objective analysis of factors that threaten the safety of local residents, such as the scale of injuries caused by internal and external factors, should be preceded, and the resident participatory safety promotion program based on them should be expanded. Method: This study looked at the safety status of Gangwon-do through various safety indicators, including the regional safety index and death from injuries, and based on this, contemplated policy measures to secure safety and reduce the risk of injuries in Gangwon-do in the future. Results: Analysis of the regional safety index showed that Gangwon-do was vulnerable in the areas of safety in daily life, suicide, and infectious diseases. In addition, an analysis of the current status of deaths from injuries showed that intentional self-harm, transport accidents, and falls were the man risk factors. Conclusion: To enhance safety and reduce deaths from injuries in Gangwon-do. first, the damage monitoring system at the province level should be operated to produce injury indicators, and second, an integrated safety network and disaster response center involving all related agencies should be established. Third, participation of residents, and fourth, supports programs for the vulnerable in the community should be expanded.
Sequential Disaster Recovery Strategy for Resilient Distribution Network Based on Cyber–Physical Collaborative Optimization

Field: Engineering (Physical Sciences)

A novel two-stage sequential disaster recovery strategy for resilient cyber-physical distribution power systems (CPDPSs) is proposed with consideration of cyber-physical collaborative optimization. In the first stage, a mixed-integer linear programming (MILP) model is formulated based on the integration of a transportation network (TN), a cyber network (CN) and a physical network (PN) to achieve efficient load recovery. Additionally, a 'repair-event-triggered' mechanism is proposed to facilitate effective and collaborative optimization among physical maintenance crews (PMCs), cyber maintenance crews (CMCs), and a distribution network recovery model (DNRM). In the second stage, PMCs and CMCs are rescheduled to repair the remaining damaged components with the lowest time cost after all the power supplies are restored. The effectiveness and applicability of this proposed model are validated using the IEEE 33 bus system and the PG&E 69 bus system.
OBSERVATIONS ON NIGHT-SKY CERENKOV RADIATION IN EXTENSIVE AIR SHOWERRS.

Field: Physics and Astronomy (Physical Sciences)

The Cerenkov light associated with EAS of sizes between aprox. 2 times 10 to the 4th and 2 times 10 to the 6th power was observed. The size spectrum of the associated showers is much flatter than that of all events, and the maximum pulse heights recorded for showers of a given size are almost independent of the particle number. This can be interpreted as a consequence of the zenith angle distribution of the EAS. The maximum intensity of the Cerenkov light was found not at the centre but at some 20 m from it. This may be explained by the angular divergence of the shower particles. (Author)