jimnoneill/paper-to-field-training huggingface dataset:
Taste masking of Metoclopramide Hydrochloride by Novel Melt Granulation.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The purpose of this research was to mask the intensely bitter taste of metoclopramide HCl by complexation with glycerol monostearate. Drug- glycerol monostearate complex was prepared by melt granulation technique in the ratio of 1:1, 1:2, 1:3,1:4. The optimum drug: glycerol monostearate ratio required for complexation was determined. The drug: glycerol monostearate complex were evaluated for the drug content, in-vivo, in-vitro taste evaluation study. The complex was characterized by FTIR, differential scanning calorimetry. The taste evaluation depicted the successful taste masking of metoclopramide HCl with drug: glycerol monostearate 1:4 ratio.
Overcoming Automatic Behavioral Tendencies in Approach‐Avoidance Conflict Decisions

Field: Psychology (Social Sciences)

ABSTRACT Adequate control over automatic responses to affective stimuli is crucial for adaptive goal‐oriented behavior. However, it remains unclear how individuals overcome automatic approach‐avoidance tendencies to appetitive and aversive stimuli. Here we examined free versus forced approach‐avoidance decisions to four conditioned stimuli (CSs), which were previously paired with either a single aversive (avCS+) or appetitive outcome (appCS+), both (i.e., conflicting) outcomes (confCS+), or no outcome (neuCS−). These CSs were presented in an anticipation phase before participants could use a joystick to either approach and obtain CS‐specific outcomes or avoid without getting anything. Response times, subjective ratings, heart rate, and eye‐tracking data were recorded in N = 75 participants. Results revealed that for single outcomes, concordant responses (e.g., avoidance to the avCS+) were faster than forced discordant responses (e.g., approach to the avCS+). During anticipation, gaze fixations shifted towards the spatial location associated with the concordant response for single‐outcome stimuli (e.g., upward for avoidance of avCS+). Conflicting stimuli elicited intermediate behavioral and gaze patterns at the group level, while exploratory analyses revealed substantial individual differences: High avoiders (i.e., participants showing an overall high proportion of avoidance) exhibited slower approach responses and greater threat‐focused visual attention compared to low avoiders. Decreased heart rate in response to all CSs suggests a general preparation of behavioral responses, while increased pupil dilation during the anticipation of aversive stimuli indicates threat‐related processing. These findings suggest that competing outcomes can amplify individual differences in motivational salience and therefore might inspire clinical interventions focused on inhibiting disorder‐specific behavioral tendencies.
REPRODUCTIVE CROPS IN THE CONDITIONS OF TYPICAL GRAYS THROUGH IRRIGARTSIA EROSION HAVE BEEN DEPENDING ON ORGANO-COMPOSTS APPLIED TO SHADOWS AND POTATOES

Field: Agricultural and Biological Sciences (Life Sciences)

In this article given information about the sat particles (accumulated) depending on the organic-mineral composts applied to soybeans and potatoes from repeated crops on the development of their growth and the impact on the agrochemical properties of the soil in the case of typical gray soils affected by irrigation erosion, after autumn wheat soils are moderately moistened.
Measurement of the standing-up motion from a chair using a luminous marker system

Field: Health Professions (Health Sciences)

In the field of rehabilitation, a reflective marker is commonly used to measure the physical movement of a subject, while it allows the motion measurement only from the direction in light. A new method was proposed for measuring the physical movement by using a luminous marker that emits infrared rays. This method enables one to simultaneously measure the movement from all directions due to the hemispheroidal radiation of infrared rays, which leads to the three-dimensional measurement of physical movements. A prototype system was developed, and the three-dimensional movement and physical parameters for the standing-up motion from a chair were demonstrated.
Radiological Diagnosis of a Neonate with Mucolipidosis II (I-Cell Disease)

Field: Medicine (Health Sciences)

Mucolipidosis II (ML II) or inclusion cell disease (I-cell disease) (OMIM 252500) is an autosomal recessive lysosomal enzyme targeting disorder. ML II is usually presents between 6 and 12 months of age with a clinical phenotype resembling Hurler syndrome and a radiological picture of dysostosis multiplex.
Studies of viral DNA packaging motors with optical tweezers: a comparison of motor function in bacteriophages φ29, λ, and T4

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

A key step in the assembly of many viruses is the packaging of double-stranded DNA into a viral procapsid (an empty protein shell) by the action of an ATP-powered portal motor complex. We have developed methods to measure the packaging of single DNA molecules into single viral proheads in real time using optical tweezers. We can measure DNA binding and initiation of translocation, the DNA translocation dynamics, and the filling of the capsid against resisting forces. In addition to studying bacteriophage φ29, we have recently extended these methods to study the E. coli bacteriophages λ and T4, two important model systems in molecular biology. The three systems have different capsid sizes/shapes, genome lengths, and biochemical and structural differences in their packaging motors. Here, we compare and contrast these three systems. We find that all three motors translocate DNA processively and generate very large forces, each exceeding 50 piconewtons, ~20x higher force than generated by the skeletal muscle myosin 2 motor. This high force generation is required to overcome the forces resisting the confinement of the stiff, highly charged DNA at high density within the viral capsids. However, there are also striking differences between the three motors: they exhibit different DNA translocation rates, degrees of static and dynamic disorder, responses to load, and pausing and slipping dynamics.
TIME OVERRUN AND ITS IMPACT ON COST OF CONSTRUCTION OF SMALL HYDROPOWER PROJECTS IN NEPAL

Field: Energy (Physical Sciences)

Hydropower is one of the main sources of energy that can be produced as green energy highlights the timely complementation of construction projects. The study is focused to assess the causes of time overrun and its impact on the cost of construction of small hydropower projects in Nepal. The study is based on pragmatic philosophy using case study and survey along with document analysis using correlation and financial decision tools. The result of the study found that all sample projects were facing time overrun. Only 30 % of the cost was due to time increment. Along with time overrun direct cost was negatively related and the indirect cost was positively related, the direct cost was more significant than the indirect cost of the hydropower project resulting in the total cost being negatively related to time increment. Profitability was decreased due to time factors though it was positive till other factors were not impacting. The research concluded that social issues and land problems were the main cause of time overrun which was not properly addressed at the time of planning. Time overrun had become the norm rather than the exception on projects. Time was a partial factor of cost overrun causing it to reduce in its profitability. Besides time, another factor which was causing the cost overrun is to be identified and control for cost overrun. The developer should focus on reducing the direct cost using advance purchase agreement as of schedule and specific care should be taken for social demand. Methods of time allocation of contract should be estimated based on activities using theory of constraints for assuring timely completion and profitability of hydropower projects.
[Examination of soluble cell adhesion molecules in pregnancy induced hypertension].

Field: Medicine (Health Sciences)

This study was performed to determine whether or not the soluble-intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1) and endothelial leukocyte adhesion molecule-1 (sELAM-1) are sensitive markers of pregnancy induced hypertension (PIH). sICAM-1 concentrations were significantly higher (p < 0.05) in the mild PIH compared to non-pregnant women and normal pregnant groups. sVCAM-1 concentrations in the mild PIH group and the severe PIH group were significantly higher than the non-pregnant women group (p < 0.0001, p < 0.01, respectively) and the normal pregnant group (p < 0.0001, p < 0.0005, respectively). The concentrations of sELAM-1 in the mild PIH group were also significantly higher compared to normal pregnant group (p < 0.01). Our results suggest that soluble cell adhesion molecules may be useful markers detecting endothelial damage and dysfunction in patients with PIH.
Comparative application of head space-solid micro-extraction and simultaneous distillation extraction for GC-MS analysis of volatile components in IRA rabbit meat

Field: Agricultural and Biological Sciences (Life Sciences)

Head space-solid micro- extraction method( HS- SPME) and simultaneous distillation extraction method( SDE) were compared for their sampling effectiveness in GC-MS analysis of volatile components in IRA rabbit meat.Totally 47 compared were identified,including 17 hydrocarbons,14 aldehydes,6 alcohols,5 esters,2 ethers,1 acid,1 ketone and 1heterocycle. 23 volatile components were identified by HS- SPME method and 26 by SDE method.Component to HS-SPME method,SDE method had more kinds of identified components,suited for high boiling point and low volatility volatile.HS-SPME method is quick and easy,closer to the real volatile flavor,suitable for easy detection of volatile compounds.
Recombinant human granulocyte colony-stimulating factor accelerates hematopoietic recovery after DLA-identical littermate marrow transplants in dogs

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract We studied whether treatment of dogs with recombinant human granulocyte colony-stimulating factor (rhG-CSF), after 920 cGy total body irradiation (TBI) and transplantation of 3.3 +/- 1.0 x 10(8) bone marrow cells per kilogram from a DLA-identical littermate, accelerated hematopoietic recovery and influenced the incidence of subsequent marrow graft failure or graft-versus-host disease (GVHD). Ten animals were treated with 100 micrograms rhG-CSF/kg/d from days 1 through 10 after TBI. Results were compared with those of historical control of 14 dogs not administered rhG-CSF. Neither group of dogs received GVHD prophylaxis. The median time to recovery of 1,000 neutrophils/mm3 was 8 days for dogs administered rhG-CSF compared with 14 days in controls (logrank test: P less than .03). The median time to reach 100 monocytes/mm3 was 17 days in G-CSF-treated dogs compared with 49 days in controls (P less than .002). The median time to attain 500 lymphocytes/mm3 was 15 days versus 31 days, respectively (P less than .01). The median time to reach 20,000 platelets/mm3 was 26 versus 20 days (P = .68). Graft failure occurred in 1 of 10 G-CSF-treated dogs versus 2 of 14 controls (two-tailed Fisher's exact test: P = 1.00). GVHD was seen in 4 of 9 rhG-CSF-treated dogs compared with 1 of 12 controls (P = .12). Two G-CSF-treated dogs died of GVHD versus none of the controls (P = .17). No unusual toxicities were seen in dogs receiving rhG-CSF. In summary, rhG-CSF significantly accelerated recovery of neutrophils, monocytes, and lymphocytes after DLA-identical littermate marrow transplantation without altering platelet recovery. Graft failure was not seen more often than in controls, but there was a trend toward an increased incidence of GVHD.
Universal Education of the Working Youth

Field: Social Sciences (Social Sciences)

The CPSU Program has posed the task of providing, by 1970, an eight-year education for that portion of the youth which is employed in the national economy and does not have an incomplete secondary education. In recent years a great deal has been done to accomplish this task. Thus, in the RSFSR the number of students of the 5th-8th grades of the evening and correspondence schools grew in five years from 369,000 to 1,201,000, and the number of students graduated with an incomplete secondary education from the evening and correspondence schools increased from 108,000 in 1959 to 341,000 in 1964. During these years, more than 1,200,000 persons in the RSFSR received an incomplete secondary education without discontinuing work. These are great successes. But there are also facts which cause alarm. First of all, there has been some reduction in the number of students in the 5th-8th grades of the evening and correspondence schools during the last three years, especially in the rural districts.
Unsteady supersonic flow around delta wings with symmetric and asymmetric flaps oscillation

Field: Engineering (Physical Sciences)

A parametric study is presented to investigate the effect of reduced frequency of the leading-edge flaps on the locally-conical, unsteady, supersonic flow around a delta wing. This study covers symmetric and antisymmetric forced oscillation of the leading-edge flaps. The effects of the freestream Mach number and angle of attack are also presented. The problem is solved using time-accurate integration of the unsteady, compressible, thin-layer Navier-Stokes equations and the unsteady, linearized, Navier-displacement equations. The delta wing is of aspect ratio of 1.5 and its leading-edge flaps are hinged at 65 percent of the local-half span length. The reduced frequency is varied between 2 pi and pi/2. Two supersonic flow conditions have been investigated; the first is for a freestream Mach number of 2.4 and an angle of attack of 19 deg and the second is for a freestream Mach number of 1.5 and an angle attack of 15 deg.
Stream Bank Erosion Contributions to Sediment Loads in Jordan Creek, Alaska: DWSM-BE Based Assessment

Field: Environmental Science (Physical Sciences)

Jordan Creek is located in the city and borough of Juneau, Alaska with a drainage area of approximately 3 square miles. It was determined to be impaired as it did not meet Alaska State Water Quality standards for sediment and dissolved oxygen. In May of 2009, A TMDL was approved to address the impairment and improve water quality. Stream bank stabilization was noted as an opportunity for future implementation. Hence, the objective of this research is to apply the Dynamic Watershed Simulation Model with Bank Erosion (DWSM-BE) to Jordan Creek in order to simulate and quantify the streambank erosion percentage of the overall sediment deposited downstream of the Jordan Creek watershed. The objective will be accomplished by combining the DWSM (to simulate hydrology, upland and streambed erosion, and sediment transport) with a detailed stream sediment transport model STREAM (with capabilities of graded sediment transport, formation of bed armoring, and stream bank erosion). The combined model DWSM-BE will be applied to the Jordan Creek watershed. The results of this research will aid in identifying regions of the stream that need critical attention for stability. A brief description of the Jordan Creek watershed and its ongoing investigations and monitoring program are presented along with a brief description of the DWSM and STREAM and the ongoing steps in combining them and applying them to the Jordan Creek watershed. Results and findings will be presented at the conference.
Street Fighter III: 3rd Strike: (CA) Roofio vs(US) Lans Light - 2021-04-23 02:08:06

Field: Arts and Humanities (Social Sciences)

(CA) Roofio vs (US) Lans Light - 2021-04-23 02:08:06 Fightcade replay id: 1619143686701-6368 Roofio: Ryu, Lans Light: Ken - 0:00:13 Ryu vs Ken Roofio: Chun-Li, Lans Light: Ken - 0:06:03 Chun-Li vs Ken Roofio: Chun-Li, Lans Light: Ryu - 0:09:28 Chun-Li vs Ryu Roofio: Ryu, Lans Light: Ryu - 0:15:22 Ryu vs Ryu For more videos check out: https://fightcadevids.com
Enriching the evidence base of co-creation research in public health with methodological principles of critical realism

Field: Health Professions (Health Sciences)

Abstract With the popularity of co-creation research in public health and other fields, there is a need to strengthen its evidence-base by developing a framework based on meta-theoretical principles. The lack of applying meta-theoretical principles in co-creation research impedes the theory- and evidence building. Critical realism seems a promising candidate for providing meta-theoretical principles to enrich the evidence base of co-creation research in public health. To this purpose we searched for relevant papers on critical realism methodological principles, clarified and subsequently applied such principles to a co-creation public health case study. We provide explanatory steps to apply five principles; 1) focusing on understanding an event, like childhood overweight, 2) exploring the broader structure and context surrounding the event, 3) constructing hypotheses about the underlying mechanism(s) of an event, 4) empirical testing to corroborate those hypotheses, and 5) using multiple methods and triangulation. Further, this study shows that critical realism can enrich co-creation research in public health by iteratively building theory and evidence following the five proposed principles.
Competition law and the digital economy: the framework of remedies in the digital era in the EU

Field: Social Sciences (Social Sciences)

In the present paper, we consider the question of the effectiveness of the remedies imposed by the EC. Our fundamental analysis stems from the reciprocal influence between Competition Law and the Digital Economy. Nowadays, Competition Law has a profound role, affecting not only direct undertakings worldwide but also indirectly by having an impact on our daily life and protecting customers. In recent years, however, the idea of creating a culture of innovation among companies has prevailed. For more than 20 years, the Digital Economy is also part of our life characterizing markets by rapid innovation and technological sophistication. The digital era has introduced the global network of economic activities and commercial transactions enabled by information and communication technologies. Through innovative products/ideas, not only the companies themselves benefit by increasing their productivity and consequently constantly creating new jobs (Alibaba, Amazon), but also consumers having the opportunity to choose a plethora of products at the best possible price.
Reducing Quantity Hallucinations in Abstractive Summarization

Field: Computer Science (Physical Sciences)

It is well-known that abstractive summaries are subject to hallucination---including material that is not supported by the original text. While summaries can be made hallucination-free by limiting them to general phrases, such summaries would fail to be very informative. Alternatively, one can try to avoid hallucinations by verifying that any specific entities in the summary appear in the original text in a similar context. This is the approach taken by our system, Herman. The system learns to recognize and verify quantity entities (dates, numbers, sums of money, etc.) in a beam-worth of abstractive summaries produced by state-of-the-art models, in order to up-rank those summaries whose quantity terms are supported by the original text. Experimental results demonstrate that the ROUGE scores of such up-ranked summaries have a higher Precision than summaries that have not been up-ranked, without a comparable loss in Recall, resulting in higher F$_1$. Preliminary human evaluation of up-ranked vs. original summaries shows people's preference for the former.
Gender incongruence in the latest International Classification of Diseases ICD-11

Field: Medicine (Health Sciences)

Aim The aim of this article is to discuss the ICD-11 with respect to the changes introduced in the classification of diagnoses related to gender identity. Method The text analyses and discusses briefly the changes concerning gender identity in the new classification of diseases with respect to the content and the language as well as to their practical implications and social dimension. Results The decision by the World Health Organisation to remove transsexualism and create a new category under the name of gender incongruence in the section other than mental illnesses and disorders had been long awaited most of all by those specialising in mental and sexual health but also by patients experiencing their gender in a way different than that assigned to them at birth.
Extent of fibrosis by high-resolution computed tomography does not improve prediction of mortality in idiopathic pulmonary fibrosis when added to a simple clinical prediction model

Field: Medicine (Health Sciences)

Background We previously reported a simple clinical prediction model for mortality (the GAP model) in idiopathic pulmonary fibrosis (IPF): Gender, Age, and Physiology (forced vital capacity and diffusion capacity for carbon monoxide). Previous studies suggest extent of fibrosis on high-resolution computed tomography (HRCT fibrosis score) is an independent predictor of survival in IPF. We evaluated the additive predictive value of fibrosis score to the GAP model for IPF. Methods We included two of three cohorts used to develop the GAP model (n=354). All patients had HRCTs available within 1 year of baseline. Two radiologists independently calculated fibrosis scores. Interclass correlation (ICC) was used to assess reliability. Models were based on competing-risks regression for mortality, treating transplant as a competing risk. Predictive performance of the GAP model and GAP + fibrosis score (GAP-FS) model was compared by the C-index, net reclassification improvement (NRI), and clinical NRI (cNRI). Results ICC for fibrosis score was 74% indicating moderate inter-rater reliability. A higher fibrosis score was associated with shorter survival on unadjusted analysis (p Conclusion When added to a simple clinical prediction model, extent of fibrosis by HRCT does not improve prediction of mortality in IPF.
HYDROBORATION AS A CONVENIENT SYNTHETIC ROUTE TO THE ALIPHATIC BORONIC AND BORINIC ACIDS AND ESTERS

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHYDROBORATION AS A CONVENIENT SYNTHETIC ROUTE TO THE ALIPHATIC BORONIC AND BORINIC ACIDS AND ESTERSHerbert C. Brown and Akira TsukamotoCite this: J. Am. Chem. Soc. 1960, 82, 3, 746Publication Date (Print):February 1, 1960Publication History Published online1 May 2002Published inissue 1 February 1960https://doi.org/10.1021/ja01488a061RIGHTS & PERMISSIONSArticle Views99Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (150 KB) Get e-Alerts Get e-Alerts