jimnoneill/paper-to-field-training huggingface dataset:
Novel alkaline ring cleavage of 2-phenyl-3-hydroxythieno[2,3-b]quinoline 1,1-dioxide, a potent inhibitor of cyclic adenosine 5'-monophosphate phosphodiesterase

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel alkaline ring cleavage of 2-phenyl-3-hydroxythieno[2,3-b]quinoline 1,1-dioxide, a potent inhibitor of cyclic adenosine 5'-monophosphate phosphodiesteraseErnest A. Harrison Jr. and Kenner C. RiceCite this: J. Org. Chem. 1979, 44, 17, 2977–2979Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/jo01331a005https://doi.org/10.1021/jo01331a005research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bacterial Fractionation of Oxygen Isotopes

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBacterial Fractionation of Oxygen IsotopesMalcolm Dole, R. C. Hawkings, and H. A. BarkerCite this: J. Am. Chem. Soc. 1947, 69, 2, 226–228Publication Date (Print):February 1, 1947Publication History Published online1 May 2002Published inissue 1 February 1947https://pubs.acs.org/doi/10.1021/ja01194a012https://doi.org/10.1021/ja01194a012research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterization of PhospholipaseA(2) Activation by Plasmin inCultured Bovine Endothelial Cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Treatment of cultured bovine carotid artery endothelial cells with 0.1 μM human plasmin has been reported to induce a receptor-mediated short burst of arachidonate release, which is a pertussis toxin-sensitive and extracellular calcium- dependent reaction. Plasmin-induced calcium influx in cells was significantly inhibited by pretreatment with pertussis toxin, indicating that the former was coupled with a pertussis toxin-sensitive guanosine 5'-triphosphate (GTP)-binding protein. Plasmin significantly induced the formation of lysophosphatidylcholine but not lysophosphatidylethanolaminc. A ccllular phospholipase A(2) with an arachidonyl specificity at the sn-2 position of phosphatidylcholine, which required submicromolar calcium, was identified as a cytosolic phospholipase A(2) by immunoblot analysis. By a cell-free enzyme activity assay and immunoblot analysis, plasmin was found to induce a translocation of the cytosolic phospholipase A(2) from the cytosol to the membrane. Taken together, the results suggest that plasmin bound to its putative reccptor and activated a GTP-binding protein coupled to calcium influx channel, followed by translocation and activation of cytosolic phospholipase A(2) in endothelial cells.
Experimental and statistical investigation of the weakest link integral and the volume effect

Field: Engineering (Physical Sciences)

A new specimen for investigation of the volume effect and scatter in fatigue data associated with different volumes is presented. This specimen contains two notches with associated volumes of different size. The WL-integral is used to estimate the probability of fatigue, and is compared to the experimental outcome. When the WL-integral is fitted to just one of the notches, the experimental outcome was well described. When fitted to both notches the fit was poor except at a failure probability of 50%. The results are almost the same whether the WL-integral is evaluated as an area-integral at the specimen surface or as a volume-integral in the specimen volume.
O-195 Mothers’ Knowledge And Practice On Management Of Childhood Acute Respiratory Infections In Albania

Field: Health Professions (Health Sciences)

<sec><st>Background and aims</st> Acute respiratory infections (ARI) are the leading cause of death among children under five in Albania. This study aims to determine the parent’s knowledge and care seeking practice related to ARI in children less than 2 years old in Albania. </sec> <sec><st>Methods</st> A cross-sectional household survey was conducted on June – July 2012 in the northeastern region of Albania. 600 mothers of children 0–23 months selected using a multi-stage sampling technique were interviewed by trained health workers using a structured pre-tested questionnaire. </sec> <sec><st>Results</st> <it>Knowledge</it>: Only 8% of mothers recognised fast/difficult breathing as a danger sign of childhood illness requiring medical attention. 78% of interviewers were convinced that every child with fever had infection and 65% of them thought they need antibiotics. <it>Care seeking practice</it>: Of the 116 children (19.3%) who reported to have respiratory illnesses two weeks preceding the interview, 57.7% had an ARI. 70.2% of children with ARI were taken to a health facility and only 53.2% of them within the first 2 days. 63.8% of ARI cases sought medical care directly at the hospital bypassing the referral system. About 36.6% of cases seen by hospital providers were prescribed antibiotics compared to 11.7% of those seen by family doctors. 20% of mothers self-administered antibiotics to their children, suggested by community pharmacists. </sec> <sec><st>Conclusions</st> Mothers’ knowledge and care seeking practices related to ARI were poor. Community health education and strengthening of Integrated Management of Childhood Illnesses programme are required to improve timely and appropriate health care of childhood illnesses. </sec>
Facilitating Consumers' Adoption of E-Government in South Africa

Field: Social Sciences (Social Sciences)

This chapter examines the diffusion and adoption of electronic governance systems (e-government) in South Africa. The purpose of the chapter is to determine how the supply side in South Africa has facilitated consumers' adoption of e-government. To achieve this objective, an extensive review of the literature encapsulating e-government, South African public services, information communication technologies (ICTs), and commerce was conducted. Findings revealed interesting results. First among many was that e-government is viewed by the government as a panacea to a plethora of socio-economic problems facing the country. It was further revealed that e-government initiatives at the municipality level are quite instrumental in driving the e-government agenda in South Africa. Of note, municipalities have rolled out various e-government programs. As a result, the country's overall e-government rankings were observed to have significantly improved in the recent past. The chapter concludes by highlighting several opportunities through which e-government could be further strengthened.
Polyphenols in Regulation of Redox Signaling and Inflammation During Cardiovascular Diseases

Field: Medicine (Health Sciences)

Cardiovascular diseases remainone of themajor health problemsworldwide.Theworldwideresearchagainst cardiovascular diseases as well as genome wide association studies were successful in indentifying the loci associated with this prominent life-threatening disease but still a sub- stantial amount of casualty remains unexplained. Over the last decade, the thorough understanding of molecular and biochemical mechanisms of cardiac disorders lead to the knowledge of various mechanisms of action of polyphenols to target inflammation during cardiac disorders. The present review article summarizes major mechanisms of polyphe- nols against cardiovascular diseases.
Metadata management tools for enterprise data management: Market Study

Field: Business, Management and Accounting (Social Sciences)

Data management turns into a key success factor for enterprises to gain competitive advantage by leveraging sustainable value from data. Documenting data management by maintaining up-to-date metadata builds the foundation for data quality, data governance, compliance, business insights and the continuous improvement of data management in all its design areas. Considering over 30 software vendors, this study report provides a comprehensive market overview of solutions that assist the management of metadata relevant for data management. A detailed analysis and comparison of the tools' capabilities for a structured description of data management speeds up the pre-selection of solutions based on your requirements. Scenarios for the introduction of a metadata management tool outline the implications of the maturity of data management and the existing tool landscape. Because leveraging business value from (meta) data requires convenient and easy access to relevant information for stakeholders without technical background, special attention is drawn to the tools' support for publishing and sharing metadata. Continuous improvement significantly depends on the collaboration of stakeholders, who discover and discuss new requirements or provide feedback about the available documentation. This is why "collaboration" is a second aspect emphasized by this market report.
Effect of Weight Bearing and Neurobic Exercises on Bone Health and Physical Function in Elderly Individuals

Field: Health Professions (Health Sciences)

Aim: To study the effect of weight-bearing and neurobic exercises on bone health and physical function in elderly individuals. Objectives: The Objectives of the study are as follows: [1] To find out the effect of weight bearing on bone health and physical function in elderly individuals. [2] To find out the effect of weight bearing and neurobic exercises in combination on bone health and physical function in elderly individuals. Method: Ethical clearance was obtained from Institutional Ethical Committee. 80 elderly individuals were assessed and 62 were included in the study based on inclusion criteria, the individuals were allocated into two groups: Group A (n=31) received Weight-bearing exercises and Group B (n=31) received Weightbearing and Neurobic exercises in combination. Pre and post-test were done for fasting serum calcium, alkaline phosphatase and SF 36 Health related quality of life questionnaire physical function component and the outcome measures were analysed after 6 weeks. Result: Intergroup statistical analysis for serum calcium (p<0.0001), Alkaline phosphatase (p<0.0001) and SF 36 physical function component (p<0.0001) revealed extremely significant difference post intervention. Analysis of serum calcium, alkaline phosphatase and SF 36 score for group A (p<0.0001) and for group B (p<0.0001) was extremely significant respectively. Conclusion: The study results concluded that Weight bearing and Neurobic exercises was significantly effective in improved bone health and physical function both individually and in combination.
Simulations of Bosonic Dark Matter

Field: Physics and Astronomy (Physical Sciences)

Dark matter is a hypothetical form of matter, which is thought to make up nearly $27\\%$ of the contents in our Universe. An increasingly popular idea is that the dark matter could be composed of light (pseudo-)scalar particles with large occupation number so that they can be described by a classical scalar field $\\phi$, with the mass $\\approx 10^{-22}$eV. As the finite energy ground state solutions for such a field, boson stars are a good subject in the study of dark matter. In this dissertation, the primary focus is on boson stars and their surrounding miniclusters. Firstly, using my new algorithms employing the Pseudo-Spectral method, I simulate the collision of two boson stars, and find the interference pattern when two boson stars overlap. The relationship between boson stars and the surrounding miniclusters are also introduced. Secondly, I study the formation and growth of boson stars in their surrounding miniclusters by gravitational condensation using the numerical method developed. Fully dynamical attractive and repulsive self-interactions are considered for the first time. In the case of pure gravity, I numerically prove that the growth of boson stars inside halos slows down and saturates as has been previously conjectured, and detail its conditions. Self-interactions are included using the Gross-Pitaevskii-Poisson equations. We find that in the case of strong attractive self-interactions the boson stars can become unstable and collapse, in agreement with previous stationary computations. At even stronger coupling, the condensate fragments. Repulsive self-interactions, as expected, promote boson star formation, and lead to solutions with larger radii. Lastly, I simulate the formation of vortices during the merger of boson stars with gravity and find that weak attractive self-interaction can be ignored in this process.
Analysis on Electricigen Genomes and Metabolic Networks

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Bioinformatics research on electricigens is the key process in microbial fuel cell(MFC) research.A variety of bioinformatics analysis methods have been applied in this field.In this review,the mainstream bioinformatics applications are summarized in the studies on electricigen genome,functional genome and metabolic network,such as gene and gene expression analysis,genome and comparative genome analysis,metabolic network reconstruction and in silico simulation.Metabolic network reconstruction is the key part between upstream genome analysis and downstream gene engineering,which is also the challenge of current related researches.Bioinformatics analysis will promote the integration between the dry experiment and wet experiment.It is used to explore the molecular mechanism of electron transfer and find key genes,optimize metabolic network,then genetic engineering methods are applied to achieve the ultimate purpose of improving the efficiency of electricity production.
Nanotribological characterization of stacked CoCrPt : SiO2 perpendicular magnetic recording media

Field: Materials Science (Physical Sciences)

In the field of magnetic recording technology, the demand for ever-increasing data storage capacity has driven the recent introduction of perpendicular magnetic recording (PMR) as an alternative to the current longitudinal magnetic recording (LMR). The PMR media have been successfully used in the hard disk drives owing to their small grain sizes, low noise, and improved thermal stability and high anisotropy, and also they have overtaken the LMR in terms of better recording performance.
Passengers’ Reflections on Railway Amenities

Field: Social Sciences (Social Sciences)

Indian Railways is the largest railway network in Asia. With a modest beginning in India on April 16, 1853, when the first wheels rolled on rails from Bombay to Thane, the Indian Railways has emerged today as the main vehicle for socio-economic development of the country. Some of the services provided by Indian Railways are freight services, parcel carrier and catering, tourism services and other related services owned by the Government of India. Indian Railways is the largest railway network in Asia. With 1.3 million employees, it is the largest employer in the organized sector in India. The main objective of this study is to analyse the passenger satisfaction and problems regarding the service provided by the Indian railways. Primary data were collected by interviewing 75 passengers of Rail transport in Tirunelveli with a specially prepared interview schedule. The researcher has applied Simple Percentage analysis, Weighted Average and one sample t- test with the help of SPSS. It is observed from the study that the sample group mainly consists of female respondents from the age group of 20-40. Most of the respondents are unmarried and graduates and are living in urban area. Most of the respondents are students and they prefer train travel because of comforts. Passengers are highly satisfied of A/C class fare. If the fare is fixed on the basis of distance, the passengers will be more satisfied.
ARABIC-THE PROPHETIC MANNERS REGARDING SLEEP AND WAKEFULNESS AND THEIR HEALTH IMPACTS (ANALYTICAL STUDY)

Field: Arts and Humanities (Social Sciences)

The life of Holy prophet has been role model throughout the history; its utmost importance cannot be denied. As a Muslim, we have to follow the Sunnah of holy prophet; it brings multiple benefits. All actions of the prophet have been reserved by Muhadditheen from his actions of worship to social activities and from economic to political actions. Eating, sleeping and walking manners are also described by Holy prophet Muhammad ﷺ. In this research, firstly, the meaning of Aadab (manners) has been defined. Secondly, the importance of sleeping for human beings has been highlighted. Moreover, sleeping etiquettes of the Prophet such as covering pots, putting out fires and closing doors before going to sleep; performing ablution before sleeping, shaking the bed before lying on it, and sleeping on the right side; not sleeping in certain times, in certain positions and private places have been presented. Additionally, advantages of those manners in terms of health have been analyzed.
ISOLATION AND IDENTIFICATION OF ENTEROHEMOLYTIC ESCHERICHIA COLI FROM SLAUGHTERED COW'S LIVER AND LUNG

Field: Veterinary (Health Sciences)

Liver and lung samples (25 for each) were collected from slaughtered cows and examend bacteriologicaly for the presence of Escherichia coli Eosin-Methylene Blue ( EMB ) and MacConkey agar positive culture (15 from liver and 12 from lung) were produced by cultivation of liver and lung samples Escherichia coli presence was confirmed biochemically in 53.3% of liver isolates and in 33.3% of lung isolates. Enterohemolytic activity was detected in 75%of both liver and lung isolates
Relationship between estimated glomerular filtration rate and diabetic macular edema in type 2 diabetic patients

Field: Medicine (Health Sciences)

AIM: To investigate the relationship between estimated glomerular filtration rate(eGFR)and diabetic macular edema(DME)in patients with type 2 diabetes mellitus(T2DM). METHODS: A total of 912 T2DM patients were enrolled in this study and underwent fundus colorized photography, fasting blood-glucose, glycated hemoglobin and renal function examinations. Estimated glomerular filtration rate assessed using modified abbreviated MDRD equation by Chinese eGFR investigation collaboration. RESULTS:Among them, 29, 21 and 47 patients had mild, moderate and severe DME, 815 patients not had DME, respectively. GFR was gradually decreased in patients with no DME, mild DME,moderate DME and severe DME(F=8.87, P<0.001). Logistic regression analysis demonstrated that lower levels of GFR was significantly associated with presence of DME. And for every 20.3 \〖mL·min-1·(1.73m2)-1\〗 decrease in eGFR, the risk of DME increased by 1.84 times. Impaired renal function and kidney disease were associated with the presence of DME when compared to normal renal function in multivariable models(1.60 and 2.46 times). CONCLUSION: In T2DM patients, lower eGFR is an independent risk factors for DME, and physicians were reminded to pay attention to changes in renal function when monitoring DME.
Rut Initiation Mechanisms in Asphalt Mixtures as Generated under Accelerated Pavement Testing

Field: Engineering (Physical Sciences)

The Florida Department of Transportation (FDOT) conducted an experiment to address the effects of polymer modifiers on the performance of Superpave® mixes by using a heavy vehicle simulator. Two fine-graded Superpave mixes were considered. One mix included a virgin binder meeting the requirements of PG 67-22, and the other contained a styrene– butadiene–styrene polymer (SBS)-modified binder meeting those of PG 76-22. Both respective mixes contained the same effective binder content, aggregate components, and gradation. The mixes were designed for 10 million to 30 million equivalent single-axle loads with the use of the standard Superpave mix design methodology. During placement of these mixes, all standard FDOT density requirements and acceptance criteria were applicable. The subsequent investigation showed that the sections with SBS-modified mixture significantly outperformed those with the unmodified mixture. It was also determined that rutting in the unmodified mixture was primarily a function of shear flow, whereas rutting in the SBS-modified mixture was caused mainly by densification. This paper presents a description of the testing program, the data collection effort, and the subsequent analyses and findings, focusing primarily on the initiation mechanisms of rutting in asphalt mixtures as generated and observed under accelerated pavement testing.
Tick Biting Experiments in Bovine and Cervine Piroplasmosis

Field: Veterinary (Health Sciences)

Summary 1. It is certain that mature Margaropus annulatus australis and Amblyoma cayenense can both be found attached to cattle and deer in Panama. No experiments have been made, with the last named type, by us. 2. Hunting experience in and near the Canal Zone has afforded one of us an excellent opportunity to examine a relatively large number of white tailed deer (Odocoileus chiriquensis Allen) and these animals usually showed the presence of a scant number of piroplasma in some of the blood cells of the cortical capillaries of the brain (crushed brain cortex film) and in some instances the peripheral blood film showed the parasites. One deer suffering from a verminous broncho-pneumonia and liver fluke disease had an associated acute attack of piroplasmosis. 3. In one instance, the progeny of ticks removed from this sick deer were capable of producing a mild attack of piroplasmosis in a half-breed, non-immune calf. The ticks in question were Margaropus annulatus australis. 4. In another instance, a mild attack of piroplasmosis was produced in a brocket deer (Mazama sartorii reperticia Goldman) by biting the animal in a massive manner with the progeny of Margaropus annulatus australis taken from prime beef cattle at the time these animals were slaughtered in Panama City. 5. Probably cervine and bovine piroplasma are identical. If not, then the tick Margaropus annulatus australis is capable of being a carrier agent for two types of piroplasma and the tick uses the deer as well as cattle for a host. 6. The practical value of these experiments is the indication that the deer makes an important reservoir for cattle piroplasmosis.