jimnoneill/paper-to-field-training huggingface dataset:
PHB2 affects the virulence of Vip3Aa to Sf9 cells through internalization and mitochondrial stability

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The vegetative insecticidal proteins (Vip3A) secreted by some Bacillus thuringiensis (Bt) strains during vegetative growth are regarded as a new generation of insecticidal toxins. Like insecticidal crystal proteins, they are also used in transgenic crops to control pests. However, their insecticidal mechanisms are far less defined than those of insecticidal crystal protein. Prohibitin 2 (PHB2) is a potential Vip3Aa binding receptor identified from the membrane of Sf9 cells in our previous work. In this paper, we demonstrated the interaction between Vip3Aa and PHB2 using pull-down, dot blotting, microscale thermophoresis, and co-immunoprecipitation assays. PHB2 is distributed on the cell membrane and in the cytoplasm, and the co-localization of PHB2 and Vip3Aa was observed in Sf9 cells using a confocal laser scanning microscope. Moreover, PHB2 could interact with scavenger receptor-C via its SPFH (stomatin, prohibitin, flotillin, and HflK/C) domain. Downregulation of phb2 expression reduced the degree of internalization of Vip3Aa, exacerbated Vip3Aa-mediated mitochondrial damage, and increased Vip3Aa toxicity to Sf9 cells. This suggested that PHB2 performs two different functions: Acting as an interacting partner to facilitate the internalization of Vip3Aa into Sf9 cells and maintaining the stability of mitochondria. The latter has a more important influence on the virulence of Vip3Aa.
Detection of RGNNV genotype betanodavirus in the Black Sea and monitoring studies

Field: Veterinary (Health Sciences)

Viral nervous necrosis (VNN), caused by betanodavirus, is a significant viral infection that threatens marine aquaculture. Freshwater and marine fish farms in Turkey are subjected to annual pathogen screenings. In 2016, during the Nervous Necrosis Virus screening program conducted in the Black Sea, betanodavirus was unexpectedly detected using real-time reverse transcription-polymerase chain reaction in apparently healthy sea bass. Phylogenetic analysis of both the RNA1 and RNA2 segments of the virus determined that the betanodavirus detected was red-spotted grouper nervous necrosis virus genotype (RGNNV). Following the initial discovery of betanodavirus in the Black Sea, monitoring studies performed over a 3 yr period have not indicated any additional presence of the virus. The absence of clinical symptoms related to VNN disease in the area’s marine fish farms and the surrounding detection zone, and the fact that the virus has not been detected anew in monitoring programmes conducted following the initial detection, indicate that there is no virus circulation in the detection zone.
Surface-wave Tomographic Inversion of the South AmericanLithosphere (The SISAL Project)

Field: Earth and Planetary Sciences (Physical Sciences)

We are studying the dispersion characteristics (measurements of group velocity) of broad band (15-2oosec) Rayleigh and Love waves propagating across the South American continent and adjacent oceans. The ultimate purpose is to invert for a high resolution, tectonic scale (lateral:5ookm) crustal and lithospheric model covering the South American, Cocos, Caribbean, Nazca and Scotia plates to depths of approximately 200 km. To date, data from more than 400 events have been analyzed yielding in excess of 4100 paths across the continent and neighboring regions. These measured group velocities are summarized in the form of tomographic maps for group velocities of Love and Rayleigh waves with periods ranging from 20 to 150 sec. We report the results of a resolution analysis (checker-board test) for a variety of periods for both Rayleigh and Love waves. The estimated group velocity maps are compared with those predicted from a recent model in which the crust is CRUST-5.1 (Mooney et. al., 1996) and the mantle is S16B30 of Masters et.al., (1996).
Study on the Accuracy and Applicability of the Pushover Analysis

Field: Engineering (Physical Sciences)

The nonlinear static pushover analysis procedure is now widely used as a simple method to estimate the inelastic seismic response for building structures.However,the accuracy of the method still needs to be validated because of the inherent limitations in its theory.Besides,there are some limitations on the application of this method.In this paper,the accuracy and the applicability of the pushover analysis procedure are verified based on the incremental dynamical analysis method with a 6-storey RC frame and an 18-storey RC frame-wall structure.The comparison between the results of the two methods shows that the pushover method can be used only for low-rise building structures that their responses are controlled by the first modal.It is also shown that for the high-rise building structures which are much influenced by the higher modal,pushover analysis always gives the much lower capacity results.
X-linked Malformation and Infantile Lethality Syndrome, Provisionally Named Ogden Syndrome

Field: Medicine (Health Sciences)

Abstract This is a lethal X-linked disorder of infancy comprising a distinct combination of distinctive craniofacial features producing an aged appearance, growth failure, hypotonia, global developmental delays, cryptorchidism, and acquired cardiac arrhythmias. The first family was identified in Ogden, Utah, with five affected boys in two generations of family members. A mutation was identified as a c.109T>C (p.Ser37Pro) variant in NAA10, a gene encoding the catalytic subunit of the major human N-terminal acetyltransferase (NatA). This same mutation was identified in a second unrelated family, with three affected boys in two generations. This X-linked Malformation and Infantile Lethality Syndrome has provisionally been named Ogden Syndrome, in honor of the hometown where the first family resides.
A Method for a Rational Choice of Technical Solution on the Basis of Distributed Features

Field: Decision Sciences (Social Sciences)

In this work, the foundations of the classification method are laid out and the possibilities of application of this method to problems of a choice of a rational technical solution referring to industrial installations are presented. The presented method is based on the notion of the shortest dendrite that corresponds to the best classification of features of a system or product. Measures of distance between objects are defined, and the way of selection of solutions based on distributed features and corresponding measures of process usefulness is proposed. As an example, the selection of an absorption system with a plate column under modernization is presented. This system is used for the elimination of orthodichlorobenzene from the stream of hydrogen chloride.
Impact of intravitreal triamcinolone injection following epiretinal membrane peeling on ectopic inner foveal layer classification

Field: Medicine (Health Sciences)

Purpose This study aimed to evaluate the impact of intravitreal triamcinolone acetonide (TA) administration after peeling of idiopathic epiretinal membranes (iERM) on both anatomical and visual outcomes, utilizing the ectopic inner foveal layer (EIFL) staging scheme. Methods In this retrospective case-control study, we analyzed 43 eyes from 43 patients diagnosed with iERM between June 2019 and December 2021. All participants were categorized into the TA or control groups based on administering intravitreal TA injection following ERM peeling. We thoroughly reviewed the clinical data, including the preoperative and postoperative best-corrected visual acuity (BCVA), central foveal thickness (CFT), and macular cube volume (VOL), with ERM stages classified according to the EIFL staging scheme. Results The study enrolled 22 eyes in the TA and 21 in the control groups. Following a mean follow-up period of 11.07 ± 2.02 months, noteworthy improvements in EIFL stages were observed in both cohorts ( p < 0.01), but without significant distinctions between groups. In the TA group, 63.64% of eyes demonstrated improvements in EIFL stages, while the control group exhibited 76.19% ( p = 0.37). At the final visit, both groups experienced a noteworthy reduction in the postoperative CFT and VOL ( p < 0.05), coupled with significant improvement in BCVA ( p < 0.01). No substantial differences appeared between the two groups concerning BCVA, CFT, and VOL (all p > 0.05). Conclusions Our study suggested that concurrent intravitreal TA injection following ERM removal did not provide additional benefits regarding anatomical and visual improvement in iERM cases classified as Stages 2 and 3.
Ruth Rice Puffer

Field: Health Professions (Health Sciences)

On September 2, 2002, at the age of 95, Ruth Rice Puffer died.

I met Dr Puffer in March 1962, when she came to the School of Public Health at the University of Sao Paulo to discuss the operational aspects of the Inter-American Investigation of Mortality in Adults. This was an international collaborative project including 10 large cities in Latin America (among them Sao Paulo), 1 city in England, and 1 city in the United States. The purpose was to get the most complete and comparable data on the deaths of adults between 15 and 74 years of age, and one of the major objectives was to find out whether the differences in mortality patterns in published statistics were real or a result of poor-quality data.

I had just completed my internship and started to work at the University Hospital at the University of Sao Paulo when I was invited to participate on the team in Sao Paulo responsible for the investigation. My job was to carefully read the interviews with the families and physicians, the hospital records, and the necropsy reports of every case included in the sample and to report the underlying cause of death, complications, and terminal cause. On the basis of this information I was to create a new death certificate. I had never participated in such an important investigation, and I knew very little about mortality statistics or even about epidemiology.
Reaction of Hexachlorobenzene and (Pentachlorophenyl)lithium with .alpha.-Arylacetonitriles

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of Hexachlorobenzene and (Pentachlorophenyl)lithium with .alpha.-ArylacetonitrilesHala Mohammed Refat, John Waggenspack, Mahesh Dutt, Hongming Zhang, A. A. Fadda, and Ed BiehlCite this: J. Org. Chem. 1995, 60, 7, 1985–1989Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/jo00112a019https://doi.org/10.1021/jo00112a019research-articleACS PublicationsRequest reuse permissionsArticle Views304Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Amplification of the p94 (n-calpain) gene of sheep and cattle

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

p94 is a muscle specific member of the calpain family that undergoes rapid autolysis in vivo, and has been linked to Limb-girdle muscular dystrophy type 2A (LMGD2A). To ascertain whether polymorphism within or near the p94 gene was responsible for different muscle phenotypes, an investigation of intron 6 was undertaken. A polymerase chain reaction (peR) involving Expand high fidelity (EHF) polymerase was developed for amplification of the region. The amplimer was investigated by polyacrylamide gel electrophoresis (PAGE) and PAGE analysis of EcoR1 digests. The results from the investigation suggest that there is no polymorphic variation between individuals within intron 6 of p94 but that there is a species difference between cattle and sheep.
Delayed cerebellar ataxia--a complication of Plasmodium falciparum malaria.

Field: Medicine (Health Sciences)

Cerebellar ataxia is an unusual post malarial complication. We encountered 10 patients of this disease (3 in 1992 and 7 in 1994) during the malaria epidemic period in Bikaner, Rajasthan. All patients were permanent residents to malaria endemic areas. The ataxic symptoms appeared after an afebrile period of 2-7 days. The neurological examination revealed no other abnormality except a cerebellar syndrome interfering with normal gait and speech. Lower limbs were affected more than the upper limbs and the mean delay between onset of fever and onset of cerebellar ataxia was 13 days. Peripheral blood film of all cases showed gametocytes of Plasmodium falciparum and in two cases schizonts of the same. All the patients improved within one month without any residual deficit. Further follow up for next 4 weeks revealed no abnormality.
Surviving the War in Syria: Survival Strategies in a Time of Conflict

Field: Social Sciences (Social Sciences)

It is estimated that of Syria's pre-war population, over half have been displaced from their homes, some having moved abroad and many remaining in the country despite the threats posed by civil war from Bashar Assad's government, ISIS, foreign intervention, and a proliferation of rebel groups and militias. Despite this, migration is just one option out of a broad set of potential self-protection strategies available to civilians, with other strategies including fighting, protesting, collaborating, or hiding. In this study, Justin Schon emphasises that civilian behaviour in conflict zones includes repertoires of survival strategies, instead of migration alone. Providing a microanalysis of civilian self-protection strategies during armed conflict in Syria, Schon draws on ten months of fieldwork in Turkey, Jordan, Kenya, and the United States, with over two hundred structured interviews with Syrian refugees. Exploring how civilians select specific survival strategies, their motives and opportunities, he reveals questions which have the potential to guide new research on civil wars, and affect how we think about other survival strategies, from political, violent, to environmental threats.
Searching by Heterogeneous Agents

Field: Computer Science (Physical Sciences)

In this work we introduce and study a pursuit-evasion game in which the search is performed by heterogeneous entities. We incorporate heterogeneity into the classical edge search problem by considering edge-labeled graphs: once a search strategy initially assigns labels to the searchers, each searcher can be only present on an edge of its own label. We prove that this problem is not monotone even for trees and we give instances in which the number of recontamination events is asymptotically quadratic in the tree size. Other negative results regard the NP-completeness of the monotone, and NP-hardness of an arbitrary (i.e., non-monotone) heterogeneous search in trees. These properties show that this problem behaves very differently from the classical edge search. On the other hand, if all edges of a particular label form a (connected) subtree of the input tree, then we show that optimal heterogeneous search strategy can be computed efficiently.
A Strategy with Novel Evolutionary Features for the Iterated Prisoner's Dilemma

Field: Computer Science (Physical Sciences)

In recent iterated prisoner's dilemma tournaments, the most successful strategies were those that had identification mechanisms. By playing a predetermined sequence of moves and learning from their opponents' responses, these strategies managed to identify their opponents. We believe that these identification mechanisms may be very useful in evolutionary games. In this paper one such strategy, which we call collective strategy, is analyzed. Collective strategies apply a simple but efficient identification mechanism (that just distinguishes themselves from other strategies), and this mechanism allows them to only cooperate with their group members and defect against any others. In this way, collective strategies are able to maintain a stable population in evolutionary iterated prisoner's dilemma. By means of an invasion barrier, this strategy is compared with other strategies in evolutionary dynamics in order to demonstrate its evolutionary features. We also find that this collective behavior assists the evolution of cooperation in specific evolutionary environments.
Amelogenesis imperfecta: functional and esthetic restoration of a severely compromised dentition.

Field: Dentistry (Health Sciences)

The treatment of patients with severe forms of amelogenesis imperfecta presents an interesting challenge to the dental team. A 16-year-old girl presented with a severely compromised occlusion and poor esthetics that had lowered her self-esteem. Preoperative investigations included the determination of completion of growth, an accurate diagnostic waxup, and an evaluation of clinical crown lengths. Periodontal full-flap surgery was planned to lengthen clinical crowns and create gingival harmony. This was to be followed by placement of 28 complete crowns to restore occlusal function and gain a pleasing esthetic result. All-porcelain crowns were placed from premolar to premolar in each arch (20 crowns), and porcelain-fused-to-metal crowns were placed on each molar tooth in each arch (8 crowns). The final treatment result provided this patient with a mutually protective occlusion and with esthetics that greatly enhanced her self-image.
Opensync: An Opensource Platform for Synchronizing Multiple Measures in Neuroscience Experiments

Field: Neuroscience (Life Sciences)

Background: The human mind is multimodal. Yet most behavioral studies rely on century-old measures such as task accuracy and latency. To create a better understanding of human behavior and brain functionality, we should introduce other measures and analyze behavior from various aspects. However, it is technically complex and costly to design and implement the experiments that record multiple measures. To address this issue, a platform that allows synchronizing multiple measures from human behavior is needed. Method: This paper introduces an opensource platform named OpenSync, which can be used to synchronize multiple measures in neuroscience experiments. This platform helps to automatically integrate, synchronize and record physiological measures (e.g., electroencephalogram (EEG), galvanic skin response (GSR), eye-tracking, body motion, etc.), user input response (e.g., from mouse, keyboard, joystick, etc.), and task-related information (stimulus markers). In this paper, we explain the structure and details of OpenSync, provide two case studies in PsychoPy and Unity. Comparison with existing tools: Unlike proprietary systems (e.g., iMotions), OpenSync is free and it can be used inside any opensource experiment design software (e.g., PsychoPy, OpenSesame, Unity, etc., https://pypi.org/project/OpenSync/ and https://github.com/moeinrazavi/OpenSync_Unity). Results: Our experimental results show that the OpenSync platform is able to synchronize multiple measures with microsecond resolution.
Dramaturgy in Motion: At Work on Dance and Movement Performance by Katherine Profeta . 2015. Madison: University of Wisconsin Press. 384 pp., 31 b/w images. $26.95 paperback. ISBN 978-0-299-30594-9

Field: Arts and Humanities (Social Sciences)

Dramaturgy in Motion: At Work on Dance and Movement Performance by Katherine Profeta . 2015. Madison: University of Wisconsin Press. 384 pp., 31 b/w images. $26.95 paperback. ISBN 978-0-299-30594-9 - Volume 49 Issue 1
A Design of Online Teacher Training Based on Learning Management System (LMS) to Improve Quality of Teaching on Higher Order Thinking Skill (HOTS)

Field: Social Sciences (Social Sciences)

This study aims to design online training for teachers based on a learning management system (LMS) so that teachers can provide higher-order thinking skills (HOTS) learning. In the era of the industrial revolution 4.0, the need for competent human resources is shown from the capabilities they have.
Mineral Crushing Methods for Noble Gas Analyses of Fluid Inclusions

Field: Earth and Planetary Sciences (Physical Sciences)

Noble gases are frequently probed for investigating fluid inclusions in minerals to unravel rock-forming processes through time. Over the last decades, heating and crushing have been the two main methods applied for noble gas extraction from fluid inclusions in ultrahigh vacuum (about 10-9 mBar). The heating of minerals or pieces of bulk rock causes the release of noble gases from both fluid inclusions and the mineral or rock matrix, the latter due to temperature-dependent mineral dehydration. Crushing of minerals only affects fluid inclusions and allows a release of noble gases at room temperature with minor contributions from the mineral matrix. This review describes different ultravacuum crushing techniques for noble gas analysis from fluid inclusions. It examines the technical details and operational conditions of each crushing system as well as methods to prepare samples prior to crushing. Crushing systems were found to have unique designs across the different laboratories reviewed; they include single or multiple sample loadings and manual, magnetic, or hydraulic operation of the crushing pistons. Due to the small amounts of noble gases released, the technology requires several mg to a few grams of rock material to achieve a measurement of all stable noble gas isotopes in a single fluid inclusion. While theoretically all stable noble gas isotopes are of interest, the elements and isotopes reported in different studies vary widely and reference materials as well as laboratory intercomparisons are lacking. The review includes applications on the origins of magmatic rocks and geochemical processes in the Earth’s mantle, the origin and chemical composition of deep crustal fluids and how these contribute to the formation of minerals of economic interest, and paleoclimate studies based on speleothems.
THE INDUSTRIAL RELATIONS EDIFICE NEARLY COMPLETED:Industrial Relations Act 1971: Code and regulation

Field: Social Sciences (Social Sciences)

THE INDUSTRIAL RELATIONS EDIFICE NEARLY COMPLETED: Industrial Relations Act 1971: Code and regulation Industrial Law Journal, Volume 1, Issue 1, 1972, Pages 95–96, https://doi.org/10.1093/ilj/1.1.95 Published: 01 June 1972