jimnoneill/paper-to-field-training huggingface dataset:
[Mechanisms of endogenous drug resistance acquisition by spontaneous chromosomal gene mutation].

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Endogenous resistance in bacteria is caused by a change or loss of function and generally genetically recessive. However, this type of resistance acquisition are now prevalent in clinical setting. Chromosomal genes that afford endogenous resistance are the genes correlated with the target of the drug, the drug inactivating enzymes, and permeability of the molecules including the antibacterial agents. Endogenous alteration of the drug target are mediated by the spontaneous mutation of their structural gene. This mutation provides much lower affinity of the drugs for the target. Gene expression of the inactivating enzymes, such as class C beta-lactamase, is generally regulated by regulatory genes. Spontaneous mutations in the regulatory genes cause constitutive enzyme production and provides the resistant to the agent which is usually stable for such enzymes. Spontaneous mutation in the structural gene gives the enzyme extra-spectrum substrate specificity, like ESBL (Extra-Spectrum-beta-Lactamase). Expression of structural genes encoding the permeability systems are also regulated by some regulatory genes. The spontaneous mutation of the regulatory genes reduce an amount of porin protein. This mutation causes much lower influx of the drug in the cell. Spontaneous mutation in promoter region of the structural gene of efflux protein was observed. This mutation raised the gene transcription and overproduced efflux protein. This protein progresses the drug efflux from the cell.
Correlation Standing Balance, Vertical jump, Sit and reach, Agility Status with Hop test Athletes with Knee Regional Sports Injuries

Field: Health Professions (Health Sciences)

Activity This inappropriate overload will increase the risk of injury occurring in sports activities to achieve performance. This is because the body is no longer able to accept the excessive load , either because the load is excessive or because the body is too heavy to accept the load, then an injury reaction will arise from our body. To assess an athlete's ability to return to sport or return to sport (RTS), tests are needed that can predict the athlete's ability after injury. Hop test is one form of test carried out. Research Method: This quantitative research cross-sectional approach. Statistical test e d by u sing spearman correlation test for bivariate test. This study involved 54patient samples at the HSF Studio clinic Results: The statistics c al test.Based on the results of the bivariate test using the sperm rho test, it shows that the results of all independent variables have no significant relationship with the dependent variable test. There is no significant relationship between standing balance, vertical jump, sit and reach test and agility standards with the hop test.
CUSTOMER ATTITUDE TOWARD MARKETING MIX ELEMENTS PERTAINING TO FOREIGN PRODUCTS IN AN EMERGING INTERNATIONAL MARKET

Field: Business, Management and Accounting (Social Sciences)

This study examines consumer attitude toward thirteen different marketing mix elements related to the products of the USA, Japan, Germany, Italy, the UK, and France in Qatar, an oil rich emerging international market. These six countries are the top six exporters to Qatar. A cross section of 98 Qatari consumers participated in the study. The common theme across the seven hypotheses that have been developed and tested is that Qatari consumers prefer most the marketing mix elements related to the products of Japan and the USA, followed by those of Germany and the least preferred ones are those of Italy, the UK, and France. The hypotheses have been partially supported. The marketing mix elements pertaining to Japanese products take the lead. The products of the USA, Germany, and the UK occupy the second position, while the products of Italy and France trail behind all others.
Exploration of stimulating children's naturalistic intelligence at Bahtera Multiple Intelligence Preschool Malaysia

Field: Social Sciences (Social Sciences)

Naturalist intelligence is a crucial aspect of early childhood development as it encourages children to recognize and directly interact with the natural environment. However, children's interaction with nature has declined due to the dominance of academic curricula and the increasing use of technology in learning, which limits environmental exploration and potentially hinders their cognitive and social development. Amid these challenges, it is essential to understand how learning strategies can be optimized to stimulate children's naturalist intelligence in a contextual manner that reflects the dynamics of field implementation, the challenges encountered, and the solutions adopted. This study employed a descriptive qualitative method using a case study approach. The research subjects were 12 students at Bahtera Multiple Intelligence Preschool, Malaysia. Data collection techniques included observation, interviews, and documentation of learning activities involving children aged 3–4 years. The results indicate that nature exploration, messy play, and nature walks are effective approaches in stimulating naturalist intelligence. These strategies are supported by the use of indoor exploration spaces and nature-based materials as solutions to external constraints such as weather conditions and high exposure to digital technology among children. These findings contribute to the development of adaptive learning strategies tailored to the characteristics of naturalist intelligence in early childhood.
The culinary intangible cultural heritage of UNESCO: a review of journal articles in EBSCO platform

Field: Arts and Humanities (Social Sciences)

The aim of this article is to identify and codify the scientific studies about intangible cultural heritage related to culinary, which integrates the List of Intangible Cultural Heritage of UNESCO, in tourism industry. For this purpose, a bibliometric research was conducted in EBSCOhost platform, it was found, between 2000 and 2017, 42 journal articles, but only 28 could be used. These were published in 18 journals, developed by 48 authors, linked to 31 institutions from 18 countries. However, only one article addressed the UNESCO’s intangible cultural heritage related to culinary. This article contributes to the identification of the nature of research being carried out in the area.
Could Bt transgenic crops have nutritionally favourable effects on resistant insects?

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract We present an idea that larvae of some Bacillus thuringiensis ( Bt ) resistant populations of the diamondback moth, Plutella xylostella (L.), may be able to use Cry1Ac toxin derived from Bt as a supplementary food protein. Bt transgenic crops could therefore have unanticipated nutritionally favourable effects, increasing the fitness of resistant populations. This idea is discussed in the context of the evolution of resistance to Bt transgenic crops.
Pengaruh Motivasi terhadap Kepuasan Kerja

Field: Business, Management and Accounting (Social Sciences)

This study aims to analyze the effect of motivation on job satisfaction as well as in improving one's performance, the hypothesis that proposed work motivation has a very significant effect on job satisfaction, leadership is very influential on employee performance in providing motivation to subordinates and for that the leader is responsible for improving the performance of that employee. Motivation is a process of giving encouragement or encouragement so that the person wants to do something to achieve a goal.
Software development team composition: Personality types of programmer and complex network

Field: Computer Science (Physical Sciences)

Several authors have identified the different personality types for software team composition. Effective personality types for software development roles is still a question.This study aims to measure the relationship between different personality types by using complex network approach for finding effective nodes of personality type for software programmer.In order to achieve the objective, the study was conducted on student population. Myer-Briggs Type Indicator (MBTI) personality assessment tool was used to obtain the personality types of participants. Furthermore, degree centrality, betweenness centrality, and closeness centrality measures were used on data. These measures were used to find the \nstrongly liked personality types among team members, personality types that can create effective communication, and personality types which can work close with other personality types. Basically, two types of results were obtained from applied measures: personality types which are weighted and frequent and personality types which are weak and less frequent.For example, ISTJ, INFJ, ISTP, and INFP personality types were found very less lucrative in working close with other personality types.On the other hand, ISTJ has been found very effective personality type for programmer role in software development literature. The results suggest that each personality type has its own complex behavior which should be extracted for better outcomes. Deciding one particular personality type for \nprogrammer role would be an injustice with it. Therefore, this paper recommends to use complex network phenomenon to extract the hidden \nfacts behind each personality types for software development roles.
Cryptococcus gattiiin an Immunocompetent Patient in the Southeastern United States

Field: Medicine (Health Sciences)

Cryptococcal infections are seen throughout the United States in both immunocompromised and immunocompetent patients. The most common form is C. neoformans . In the Northwestern United States, C. gattii has received considerable attention secondary to increased virulence resulting in significant morbidity and mortality. There are no cases in the extant literature describing a patient with C. gattii requiring neurosurgical intervention in Alabama. A middle-aged immunocompetent male with no recent travel or identifiable exposure presented with meningitis secondary to C. gattii . The patient underwent 12 lumbar punctures and a ventriculoperitoneal shunt and required 83 days of inpatient therapy with 5-flucytosine and amphotericin B. The patient was found to have multiple intracranial lesions and a large intramedullary spinal cryptococcoma within his conus. Following an almost 3-month hospitalization the patient required treatment with oral voriconazole for one year. In the United States meningitis caused by C. gattii infection is not isolated to the Northwestern region.
Usefulness of Magnetic Resonance Imaging for the Diagnosis of Hemochromatosis with Severe Hepatic Steatosis in Nonalcoholic Fatty Liver Disease

Field: Medicine (Health Sciences)

The ratio of the number of patients with non-alcoholic steatohepatitis (NASH) to the total number of patients with liver dysfunction has increased in many countries around the world. Liver dysfunction is also caused by multiple blood transfusions in patients with leukemia and other hematological diseases, with liver dysfunction often accompanied by secondary hemochromatosis. This study describes a 25-year-old man with secondary hemochromatosis combined with NASH. Magnetic resonance imaging was useful for visualizing the distributions of both iron and fat in the liver of this patient in order to make a differential diagnosis and to evaluate the effect of treatment.
Development of FDEM and applicability to river embankment survey

Field: Earth and Planetary Sciences (Physical Sciences)

河川堤防の安全性を検討する場合、対象区間においてボーリング調査をポイント的に行いボーリング間の地層については補完的に設定していることが一般的と思われる。しかし、ボーリング地点の間隔が長い場合、その区間内がボーリング結果から補完した地層区分どおりの状態であるとは限らず、脆弱層の見落とし等が懸念される。本研究において周波数領域電磁探査法（Frequency Domain Electromagnetic Method:以下、略してFDEM探査法と呼ぶ）は、従来のFDEM探査機を改良開発したもので、探査機を地表面に置くだけで非破壊的に直下の比抵抗分布を迅速に探査することが可能である。したがって、河川堤防のような長い区間の地層状態を比抵抗分布から推定する手法に適していると思われ、比抵抗は含水比や粘土や礫の含有量等に相関があることからボーリング結果とキャリブレーションしながら解析すればさらに精度の高い地層区分や脆弱層の位置を推定できるものと考えられる。本研究においては、新しく開発されたFDEM探査機と測定原理に関する理論的な考察を述べるとともに、数ヶ所の河川堤防で行った現位置における探査結果から、本手法の適用性について検討した。
PENYULUHAN HUKUM TENTANG PROSEDUR PENANGANAN PERKARA PIDANA DI DESA SANGIANG, MAJALENGKA

Field: Social Sciences (Social Sciences)

Every citizen has the right in law and justice, because of that the government made Law number 16 of 2011 concerning Legal Aid to protect its citizens in the event of a disaster that befalls the community. The purpose of community service is more focused on the people or villagers, while the other objectives of this counseling are the parents who can add information related to the process of handling criminal acts and how to follow up in the event of a crime. The method used is by way of lectures and discussions then ends with questions and answers. The results obtained from this community service are that the community is more sensitive and knows how criminal law and the process of resolving criminal acts, starting from the investigation and investigation, prosecution and court decision. defendant.�Keywords: Legal Aid, Prevention, Socialization.AbstrakSetiap warga negara mempunyai hak dalam hukum dan keadilan, oleh kerana itu pemerintah membuat Undang-Undang nomor 16 Tahun 2011 tentang Bantuan Hukum untuk melindungi warganya dalam hal terjadi musibah yang menimpa masyarakat. Tujuan pengabdian kepada masyarakat ini lebih menitik beratkan kepada orang-orang atau warga desa, adapun sasaran lain yang menjadi tujuan dari diadakannnya penyuluhan ini yaitu para orang tua yang mana dapat menambah informasi terkait dengan proses penanganan tindak pidana dan bagaimana menindaklanjuti apabila terjadi tindak pidana. Metode yang digunakan yaitu dengan cara ceramah dan diskusi kemudian diakhiri dengan tanya jawab. Hasil yang diperoleh dari pengabdian kepada masyarakat ini yaitu masyarakat lebih peka dan mengetahui bagaimana hokum pidana dan proses penyelesaian tindak pidana yaitu mulai dari penyelidaikan dan penyidikan, penuntutan dan putusan pengadilan.masyarakat mengetahui tentang tahapan-tahapan dalam proses penyelesian perkara pidana yang dilalui seorang tersangka atau terdakwa.�Kata Kunci: Bantuan Hukum, Pencegahan, Sosialisasi.
A Low-RCS and High-Gain Planar Circularly Polarized Cassegrain Meta-Antenna

Field: Engineering (Physical Sciences)

Achieving highly directive radiation with broadband operation, low scattering, and thin profile for a circularly polarized (CP) antenna is particularly challenging and yet rarely reported. Here, we propose a strategy of a CP Cassegrain meta-antenna by combining a planar helical antenna, a metasurface main reflector, and a metamaterial subreflector. The main reflector is designed to achieve focusing for CP waves at 13 GHz. The subreflector is chessboard-configured chiral metamaterial slab composed of two different types of chiral meta-atoms, aiming to achieve spin- and direction-selective CP transmissions and reflections. The distance between two reflectors is half of focal length, which enables our antenna to be dubbed as a folded reflectarray. The low radar cross section (RCS) is achieved based on scattering cancellation technique by realizing near 180° reflection phase difference between two neighboring chessboard submeta-atoms. Thanks to the architecture of the two reflectors, the proposed antenna exhibits high gain and low profile simultaneously according to image theory. For verification, a planar CP Cassegrain antenna, excited by a left-handed CP (LCP) planar helical antenna, is numerically studied, fabricated, and experimentally measured. Numerical results are in good agreement with the experimental ones, showing a peak right-handed CP (RCP) gain of 26.6 dBi at 12.6 GHz. Furthermore, the backward monostatic RCS of the antenna is dramatically reduced over −10 dB in a broad bandwidth from 8.4 to 15.7 GHz when it is illuminated by an LCP planar wave. Our proposed Cassegrain antenna features simultaneously broadband, high gain, low profile, and low RCS, providing a new avenue to low-profile CP reflectarrays with invisibility.
Congenital Langerhans cell histiocytosis involving only one of non-identical twins

Field: Medicine (Health Sciences)

ejd.2011.1402 Auteur(s) : Rosa Fernandez-Torres1 rosaftorres@gmail.com, Elena Granero2, Sabela Paradela1, Eduardo Fonseca1 1 Department of Dermatology, CHUA Coruna, Xubias de Arriba 84, 15006 A Coruna, Spain 2 Department of Pathology, Hospital La Paz, Paseo Castellana 261, 28046 Madrid, Spain Langerhans cell histiocytosis (LCH) encompasses a spectrum of diseases with heterogeneous clinical manifestations and prognosis. Congenital LCH with systemic involvement (Letterer-Siwe disease) is very uncommon, [...]
Gravothermal Oscillations

Field: Physics and Astronomy (Physical Sciences)

We present the first clear evidence that the gravothermal oscillation takes place in N -body systems. We performed direct N -body simulations of systems of point-mass particles with particle numbers from 2,048 to 32,768. In the simulation with 32,768 particles, the central density shows an oscillation with an amplitude of ∼ 10 3 , which is similar to what was observed in more approximate models such as a conducting gas sphere and one-dimensional Fokker-Planck calculations. The amplitude is smaller for a smaller number of particles. The number of particles in the core at the maximum contraction is ∼ 10 for all runs, while the number of particles at the maximum expansion is about 0.01 N. For 16,384- and 32,768-body runs, the temperature inversion during the expansion phase is clearly visible.
Depressor Septi Nasi Modifications in Rhinoplasty: A Review of Anatomy and Surgical Techniques

Field: Medicine (Health Sciences)

The anatomy of the nasal muscles contributes a social harmony in aesthetic rhinoplasty because these muscles coordinate the nose and the upper lip while smiling. Sometimes this coordination can be interrupted by the hyperactivity or variations of these muscles and may result as a deformity because of their dynamic functions and relations with the nose. In our daily practice, we usually perform the rhinoplasty without considering the dynamic functions. When the patients recover the muscle functions after operation and start to use their mimics, such as smiling, the undamaged dynamic forces may start to rotate the tip of the nose inferiorly in a long-term period, correlated with their preoperative function. To avoid this unexpected rotation it is essential to remember preoperative examination of the smile patterns. To manage this functional part of rhinoplasty, we aimed to clarify the smiling patterns or deformities mainly focused on depressor septi nasi muscle in this article. This muscle creates downward movement of the nasal tip and shortens the upper lip during smiling. The overactivity of this muscle can aggravate the smiling deformity in some patients by a sharper nasolabial angle correlated with levator labii superioris alaeque nasi and orbicularis oris muscle activities. The article not only stresses the correction of this deformity, but also aims to guide their treatment alternatives for correlation of postoperative results and applicability in rhinoplasty.
Conceptual Design of a Low-Cost Class-III Turbofan-Based UCAV Loyal Wingman

Field: Engineering (Physical Sciences)

The rapid evolution of military technology has led to an increased interest in Unmanned Combat Aerial Vehicles (UCAVs). This research focuses on the conceptual design of a low-cost, turbofan-powered UCAV, specifically a Class-III aircraft as defined by NATO classification (STANAG 4670), with a target take-off weight of approximately one tonne. The study adopts a “from scratch” design approach, recognizing the limitations of existing data and the potential for scaling errors. This approach involves a meticulous design process that includes the development of precise requirements, weight estimations, and iterative optimization of the aircraft layout to ensure aerodynamic efficiency and operational functionality. A key element of this conceptual design is its focus on a low-cost profile, achieved through the adoption of a simplified structural layout, and the integration of off-the-shelf components where possible. The design process involves an iterative approach, beginning with fundamental requirements and progressing through the detailed development of individual components and their integration into a cohesive aircraft. The study details the selection of an existing and operational engine due to its power output. The design and analysis of the wing, fuselage, and V-tail configuration are presented, incorporating considerations for aerodynamic efficiency, stability, weight estimation, and internal component layout. The study concludes by outlining recommendations for future work, including high-fidelity CFD simulations, structural analysis, and the integration of advanced electronic systems and AI capabilities essential for the Loyal Wingman concept.
Peculiarities of excitation of the Earth–ionosphere waveguide at frequencies above the frequency of the first transverse resonance

Field: Physics and Astronomy (Physical Sciences)

Experimental data on the registration of signals from tweek-atmospherics and an ionospheric source formed because of heating of the ionosphere at frequencies higher than the frequency of the first transverse resonance of the Earth–ionosphere waveguide (~1.8 kHz) are considered. It is shown that, far from the source, at frequencies near the resonance, almost complete circular left-hand polarization of the horizontal magnetic field is observed, and the angles of incidence are small and range from 10° to 35°. A joint analysis of observational data and simulation results showed that it is possible to calculate the effective reflection height from estimates of the incidence angle, which can be used to diagnose the lower ionosphere. But, in the case of an ionospheric source, it is important to take into account the inhomogeneity of its radiation pattern.
Human rights and public health: towards a balanced relationship

Field: Social Sciences (Social Sciences)

This contribution attempts to scope the multiple and complex relationships between measures to protect health and the protection of human rights. The article begins with a discussion of the meaning and current understandings of the notion of ‘public health’, after which it explores how ‘public health’ is framed in various branches of public international law, including international trade law, the law of armed conflict and international environmental law. Subsequently, in light of these developments, it discusses whether the ‘right to health’ can be used as a collective claim to advance the health of the public, possibly in support of the existing public health clauses under international law. In such cases the protection of public health, and potentially the ‘right to health’, may clash with the interests of international and domestic trade and commerce, intellectual property protection, and the conduct of warfare. Another tension exists where measures to protect the health of the public infringe on the civil and political rights of individuals, including their rights to privacy and freedom of movement, but also their individual right to healthcare. This may occur both within and beyond healthcare settings, for example when it comes to quarantine, (forced) testing, and border restrictions in the interests of public health, but also in the fields of biomedical research and the testing of medicines. The existing limitation clauses under civil and political human rights law provide some guidance as to how such measures should be taken, however there is a need for a better understanding on how to implement these tools.