jimnoneill/paper-to-field-training huggingface dataset:
Open right hepatectomy in a patient with hepatocarcinoma and pulmonary hypertension

Field: Medicine (Health Sciences)

Liver resection is the most effective treatment for primary and secondary malignancies.A major limitation of liver surgery is the high morbidity and mortality related to blood loss and liver function.The difficulty of the procedure and perioperative management may increase due to the association of comorbidities, such as the present case of a patient with hepatocarcinoma and pulmonary hypertension.
Caffeic Acid and Biopesticides Interactions for the Control of Storage Beetles

Field: Agricultural and Biological Sciences (Life Sciences)

Infestations of stored-product pests cause significant losses of agricultural produce every year. Despite various environmental and health risks, chemical insecticides are now a ready-to-use solution for pest control. Against this background and in the context of Integrated Pest Management research, the present study focuses on the potential insecticidal effect of caffeic acid at five different concentrations (250, 500, 750, 1500 and 3000 ppm), and their combination with Cydia pomonella Granulovirus (CpGV), Bacillus thuringiensis subsp. tenebrionis and Beauveria bassiana strain GHA on three major insect stored-product beetle species, Tribolium confusum (Coleoptera: Tenebrionidae), Cryptolestes ferrugineus (Coleoptera: Laemophloeidae) and Trogoderma granarium Everts (Coleoptera: Dermestidae). Treatment efficacy was expressed as mortality in relation to exposure time and adult species number. Compared to the control, the results showed a clear dose-dependent pesticidal activity, expressed as significant adult mortality at a high-dose application, although some of the combinations of caffeic acid concentrations with the other substances acted positively (synergistically and additively) and some negatively. Based on our results, bioinsecticides can be combined with plant compounds such as caffeic acid and be integrated with other modern IPM tools in storage facilities.
Performance persistence of emerging markets equity mutual funds

Field: Economics, Econometrics and Finance (Social Sciences)

Esta tese analisa o desempenho de fundos mútuos de ações de mercados emergentes durante o período de janeiro de 2005 a dezembro de 2017. O objetivo é preencher a lacuna metodológica da literatura de mercado desenvolvida presente em estudos recentes. Na primeira parte, a análise de performance demonstra que os alfas são positivos e estatisticamente significativos. Assim, encontro evidência de que os fundos mútuos geraram retornos anormais durante todo o período amostral, embora a análise por subperíodos produza resultados menos claros, havendo subperíodos em que os alfas são negativos ou positivos. Além disso, mostro que a relação de despesas, cargas front-end e back-end têm impactos negativos sobre os alfas, como esperado. Na segunda parte, a análise de persistência de performance mostra que os spreads entre os fundos com performance mais alta e mais baixa são positivos durante os diferentes períodos de investimento, em outras palavras, os fundos com melhor performance continuam superando seus pares inferiores nos períodos subsequentes. Portanto, encontro evidências de persistência de performance em períodos de investimento de até um ano. Os resultados também mostram que mesmo os fundos com performance mais baixa foram, em média, capazes de gerar alfas positivos ao longo de diferentes períodos de espera.
Clinical outcomes of non‐surgical root canal obturations using NeoMTA: A retrospective series of case reports

Field: Dentistry (Health Sciences)

Abstract NeoMTA is a commercially available tricalcium silicate‐based cement intended for contact with pulp and periradicular tissues. The purpose of this study was to retrospectively evaluate the outcomes of non‐surgical root canal treatments with NeoMTA obturations. Patients were treated in a private endodontic practice between 2015 and 2018. All cases, including initial treatments and retreatments, were either fully obturated with NeoMTA, or using gutta‐percha with NeoMTA as an endodontic sealer. Outcomes were assessed using follow‐up examination data with digital periapical radiographs with a minimum of a 1‐year recall. Teeth were classified based on the clinical examination as: healed/healing (success), or non‐healed (failure). 265 teeth were included with an average follow‐up time of 1.3 years. The overall success rate was 91.7%. Only the presence of a pre‐operative periapical radiolucency was found to significantly affect success. Comparison of obturation techniques demonstrated no effect on outcomes. NeoMTA is suitable for endodontic obturation.
Braille-to-Chinese Translation System Based on Optical Braille Recognition

Field: Computer Science (Physical Sciences)

Braille is an essential tool for visually impaired people to receiving and transmitting information. However, sighted people without special training cannot read Braille, which will cause inconvenience to scenarios such as special education that require sighted people to read Braille. This paper implements a Braille-to-Chinese translation system composed of optical Braille recognition, Braille-to-pinyin conversion, and pinyin-to-character module. Experiments prove that our system can effectively and accurately translate Braille images into Chinese. Our system has broad application prospects, which can help the sighted people read Braille and help visually impaired people in their study and life.
Protein binding of valproic acid in Japanese pediatric and adult patients with epilepsy

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The binding of valproic acid to serum proteins in pediatric and adult patients was studied. Serum samples were obtained from 48 Japanese pediatric patients with epilepsy (group A) and 48 Japanese adult patients with epilepsy (group B) receiving valproic acid monotherapy. The patients' age ranged from 1 to 15 years for the pediatric patients and from 18 to 44 years (group B--younger) and 45 to 63 years (group B--older) for the adult patients. The serum concentrations of total and unbound valproic acid were measured by fluorescence polarization immunoassay, and the unbound serum fraction of valproic acid was analyzed by ultrafiltration. The mean association constant, K, and total concentration of binding sites, n(P), were as follows: group A, K = 0.016 L/mumol, n(P) = 1077 microM; group B, K = 0.011 L/mumol, n(P) = 1365 microM; group B--younger, K = 0.013 L/mumol, n(P) = 1291 microM; and group B--older, K = 0.006 L/mumol, n(P) = 1827 microM. Significant differences between groups A and B were observed in the serum free fatty acid concentration and the serum concentration ratio of free fatty acids to albumin. However, no significant differences between the two groups were observed in the binding of valproic acid to serum proteins. Group A's serum concentration ratio of free fatty acids to albumin was significantly lower than in group B--older and was lower than in group B--younger. However, there were no significant differences in binding between group A and groups B--younger and B--older. The serum concentration of albumin was significantly higher in group B--younger than in group B--older. Consequently, there was a significant difference in binding between groups B--younger and B--older. The serum protein binding of valproic acid was similar in pediatric and adult patients with epilepsy, but binding characteristics differed between younger and older adults.
Pulmonary papillary adenocarcinoma with psammoma bodies metastasis to right frontal lobe

Field: Medicine (Health Sciences)

Objective To investigate the clinical manifestations and pathological characteristics of pulmonary papillary adenocarcinoma with psammoma bodies metastasis to right frontal lobe of brain. Methods The clinical manifestations, pathological features and differential diagnosis were studied in one case of pulmonary papillary adenocarcinoma with psammoma bodies metastasis to right frontal lobe. Related literatures were also reviewed. Results A 56-year-old male suffered from intermittent headache for 3 years in fronto-occipital region without significant incentives. Cranial MRI examination revealed a space-occupying lesion in right frontal lobe, which was considered as meningioma. In operation, the tumor located in the right frontal lobe was tough and red-grey in color, with clear boundary and abundant blood supply. Histopathological examination revealed the tumor was arranged in papillary pattern. The tumor cells were large, with eosinophilic cytoplasm, round or oval nuclei and small red nucleoli. Especially, a plenty of psammoma bodies were found in tumor tissue and mesenchymal tissue. Immunohistochemical staining found that the tumor cells were positively expressed for cytokeratin (CK), epithelial membrane antigen (EMA), CK19, thyroid transcription factor-1 (TTF-1) and Napsin A, and showed focal positive expression of P53. Ki-67 labeling index was 5%-10%. The tumor cells were negative for glial fibrillary acidic protein (GFAP), S-100 protein (S-100), thyroglobulin (TG), Galectin-3 protein, progestrone receptor (PR) and vimentin (Vim). Combined with the results of chest 18F-FDG-PET CT, the final diagnosis was pulmonary papillary adenocarcinoma with psammoma bodies metastasis to right frontal lobe. The patient underwent auxiliary radiotherapy and chemotherapy after operation. The patient was followed for 12 months and no recurrence was seen. Conclusions This case is very rare. Understanding the patient's history and differentiating from other primary intracalvarium tumors is one of the key steps to give the right pathological diagnosis and clinical therapy. In order to avoid disdiagnosis, the diagnosis needs to be differentiated from other primary intracalvarium tumors, including papillary meningioma, papillary tumor of choroid plexus, papillary ependymoma, papillary glioneuronal tumors as well as metastatic papillary thyroid carcinoma. DOI: 10.3969/j.issn.1672-6731.2015.06.009
Moroccan SMEs and the Casablanca Stock Exchange: Governance Issues and Prospects for Introduction

Field: Business, Management and Accounting (Social Sciences)

This research paper examines the relationship between corporate governance mechanisms and Moroccan SMEs' access to the Casablanca Stock Exchange. It highlights the importance of SMEs in the Moroccan economy, their key role in value creation and economic growth, and the challenges they face in accessing finance, particularly through the capital markets. The text also explores corporate governance systems, comparing open (Anglo-Saxon) and closed (continental European) models, and situates Morocco in a closed system with a high concentration of capital in large companies. Cross-tabulation and multiple correspondence analysis reveal significant correlations between IPO and various variables, such as the presence of an audit committee, a corporate governance body and knowledge of good governance codes. The econometric model, based on binary logistic regression, confirms that the presence of an audit committee is the main determinant of IPO, significantly increasing the probability of listing. On the other hand, other variables such as beliefs and values, the management system, capital concentration or the management market did not show any significant correlation, highlighting that the quality of internal governance plays an essential role in access to the financial market in Morocco.
Making the Classic Contemporary: Lawrence’s Pilgrimage Novels and American Romance

Field: Arts and Humanities (Social Sciences)

Lawrence's American literature studies stand high in current opinion, especially in America, where a flourishing school of mythic criticism is built on them.1 A related question, equally significant but seldom addressed, is how his reading of Melville, Hawthorne and others affected form and substance in his own novels. An exception to the general silence on this question, Richard Swigg, has shown how much Women in Love owes to precepts Lawrence gleaned from 'classic' American literature. 2 But after that novel, Swigg declares, Lawrence's Old World intelligence resisted his New World irrationality, and after a season of 'spurious victories' culminating in 'the disaster of The Plumed Serpent', he recovered his balance, always exempt from the 'touch of mental bitterness, of black disorder' that plagued the American authors.3 On the contrary, Lawrence's own 'mental bitterness' and 'black disorder' were the chief source of his affinity for these Americans. Nonetheless, judgements like Swigg's continue to be repeated, generally arriving at the conclusion that Lawrence's novels between Women in Love and Lady Chatterley's Lover are failures. 4
Ligand Binding and Catalysis in Selected Sirtuin Isozymes

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Due to their intimate roles in survival, longevity as well as pathogenesis via ?epigenetic? and ?metabolic? regulatory mechanisms, sirtuins have gained considerable interest toward undertaking detailed biochemical/biophysical studies. The present study was designed to ascertain the mechanistic details of ligand binding and catalysis in selected sirtuin isozymes (viz., SIRT1 and SIRT5) from the point of view of designing isozyme selective inhibitors as potential therapeutics. By screening of the in-house synthesized compounds, two barbiturate derivatives were identified as the SIRT5 selective inhibitors. These, along with some of known inhibitors of SIRT1 and SIRT5, namely, MH5-75, nicotinamide, suramin were investigated by a combination of spectroscopic, kinetic, and thermodynamic techniques. The influence of the sirtuin inhibitors in modulating the structural features of the enzymes were ascertained by CD spectroscopic, lifetime fluorescence, and thermal denaturation studies using wild-type and selected site-specific mutant enzymes. The experimental data revealed that the substrate selectivity and inhibitory features in SIRT5 were manifested via the mutual cooperation between Y102 and R105 residues of the enzyme, and the overall catalytic feature of the enzyme was modulated by changes in the protein structure. Whereas the stoichiometry of SIRT1 to suramin remained invariant as 1:1, that of SIRT5 to suramin increased from 1:1 to 2:1 upon increase in the molar ratio of the enzyme to the ligand. A comparative account of the experimental data presented herein sheds light on the structural-functional differences between SIRT1 and SIRT5, leading to the design of isozyme selective inhibitors as therapeutic tools for the treatment of sirtuin associated diseases.
Dataset related to article "Phase II trial of high dose stereotactic body radiation therapy for lymph node oligometastases"

Field: Medicine (Health Sciences)

This record contains raw data related to article "Phase II trial of high dose stereotactic body radiation therapy for lymph node oligometastases" Lymph nodes are common sites of oligometastases for several primaries. Stereotactic body radiation therapy (SBRT) represents an effective treatment but no consensus exists regarding dose and fractionation. Aim of this trial was to evaluate safety and efficacy of high-dose SBRT. We included patients with 1 to 3 lymph node metastases. Primary end-point was safety, while secondary end-points were in-field local control (LC), out-field lymph nodal progression free survival (LPFS), distant metastasis free survival (DMFS), progression free survival (PFS) and overall survival (OS). 64 lesions in 52 patients were treated from 2015 to 2019. Most common primary tumor was genitourinary cancer (75%), in particular prostate cancer (65.4%). With a median follow-up of 24.4 months (range 3-49), treatment was very well tolerated, with only 4 (7.7%) patients reporting acute side effects, all classified as grade 1, in the form of pain, fatigue, nocturia and dysuria. No toxicity ≥ grade 2 were reported. Rates of LC at 1, 2 and 3 years were 97.9%, 82.1% and 82.1%. Male sex (HR 0.12, p value 0.014) was associated with improved LC. LPFS at 1, 2 and 3 years were 69.6%, 49.6% and 46.1%, respectively, and DMFS was 81.74%, 67.5% and 58.5%, respectively. Presence of lesions in other organs was correlated with inferior DMFS (HR 3.82, p = 0.042). PFS at 1, 2 and 3 years were 67.4%, 42.4% and 31.86%, respectively. OS at 1, 2 and 3 years were 97.3%, 94.2%, 84%, respectively and significantly correlated with in-field recurrence (HR 8.72, p = 0.000). Our prospective trial confirms safety and efficacy of SBRT in the management of lymph node metastases. Registered Clinical trial NCT02570399.
Collapse fragility curve development using Monte Carlo simulation and artificial neural network

Field: Engineering (Physical Sciences)

Seismic fragility curves represent likelihood of structures meeting various damage stages. Epistemic as well as aleatory uncertainties associated with seismic loads and structural behaviors are usually taken into account in order to analytically develop such curves. Such structural analyses are time-consuming, demanding extensive computational efforts. In this study, in order to reduce this endeavor, artificial neural network method is applied to develop structural seismic fragility curves under collapse damage state, considering effects of record-to-record variability and modeling parameter uncertainties. Structural analyses are performed for a limited number of scenarios of structures under a limited number of recorded strong ground motion records. Probability distribution for each modeling parameter was used to simulate each structure scenario. Incremental dynamic analysis was used to assess spectral acceleration associated with collapse limit state for each structure scenario. The results of the analyses were used to train and validate a three-layered artificial neural network, and Monte Carlo simulation is implemented based on trained neural network for a sample moment-resisting steel frame in order to derive collapse fragility curve. Application of the proposed method enhances accuracy of identical computational run time compared with response surface–based method.
Induction of minisatellite DNA reanrangements by genotoxic carcinogens in mouse liver tumors

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

We investigated whether somatic rearrangements in minisatellite DNA are more frequent hi chemically induced mouse liver tumors than they are hi spontane-ous tumors, CD-I mouse liver tumors were induced by either a single dose or 15 consecutive daily doses of 7,12-dimethylbenz[a]anthracene, 4-amlnoazobenzene, N-hydroxy-2-acetyl-aminofluorene or diethylnitrosoamine (DEN). Using DNA fingerprinting analysis, we found that the single- and multiple-dose carcinogen treatments caused a 2- to 5-fold higher frequency of minisatellite DNA rearrangements compared with that found hi spontaneous tumors—with the exception of single-dose DEN tumors, which showed no increase hi rearrangements. O.ir results suggest that DNA fingerprinting may be a valuable assay for differentiating certain chemically induced tumors from spontaneous tumors.
Angola Biodiversity of Bathyal Sea Bottoms

Field: Environmental Science (Physical Sciences)

Abstract At the request of TOTAL E&P Angola (TEPA), before developing oil and gas activity, independent contractors carried out seven environmental baseline studies between 1998 and 2009 on bathyal blocks 17 and 32 located off the coast of Angola. With this aim, biological analysis were done on seabed samples at depths ranging between 682 and 2630 m, and 515 benthic macrofaunal taxa from eleven phyla were discovered. The relative dominance on richness taxonomic and abundance was observed on Polychaetes, but referring to species’ abundance it was found the sipunculid Onchnesoma steenstrupi (78 ± 72 ind./m2) with the major representation in samples (94%). The general composition of benthic macrofauna communities was very similar between sites despite the wide range of depths. This suggested relatively high ecosystem homogeneity in space and time. Average taxon richness per station (41 ± 11) was relatively high and the Shannon-Weiner diversity index very high (4.5 ± 0.5). Total density was relatively low (409 ± 179 ind./m2), as well as dry weight total biomass (0.57 ± 1.27 g/m2). Such levels of structural indices were consistent with common deep-sea soft sediment records. Increasing biodiversity from deep offshore Block 17 sites to ultra-deep offshore Block 32 area also was concordant with previous deep Angola Basin observations. When performing the taxonomic identification of species encountered in this work, it was estimated that about 80% of species found in both blocks were new to science. In respect of trophic structure of the groups, it was found that there was dominance of detritus deposits in relation to suspension feeders. Finally, it was also concluded that the state of the environment was stable, the ecosystem was in equilibrium and there was a high level of biodiversity.
The Spirituality of Tour Guides and their Impact on Visitors Experience at Sacred Sites

Field: Social Sciences (Social Sciences)

It has been widely acknowledged that tour-guides play a vital role in the visitor experience, and significantly impact on the sort of experiences visitors get at sites visited (Cohen et al.,2002; Pizam & Riechel, 1996), and have been dubbed as key elements in the complex interaction between the visitor and the sites visited (Cohen-Hattab and Shoval 2015). Although there has been a proliferation of studies conducted with regards to the role of tour guides in visitor’s experience at cultural heritage tourism attractions, there is still very little exploration of the role of tour guides in the visitor experience management at sacred sites, and especially how their spirituality impacts on the visitor’s experience at these ecclesiastical sites within the religious and pilgrimage tourism scholarship. Crucial given that these personal attributes may directly or indirectly play a vital role in influencing their narratives and interpretations of these holy places, and consequently impact on visitor satisfaction. The lack thereof of a scholarly investigation into this phenomenon, suggests the timeliness of an exploration into how the spirituality of these tour-guides/ leaders influences visitor experiences at these sites. Thus, in providing an understanding into this phenomenon, semi-structured interviews conducted with tour-guides at Irish sacred sites, revealed that the spirituality of tour-guides either based on religion or upon secular does influence tour narratives and site interpretation and consequently impacts on the visitor’s experience. The research has significant implication for sacred site visitor experience management, where there is a need to understand how the socio-psychological characteristics of these sacred site tour-guides/ leaders impact on the visitor’s experience and the effects on the image of these holy places. The findings, thus, advances scholarly discourse on the rather complex and sensitive sacred sites visitors experience management phenomenon.\nSelected readings:\nCohen-Hattab, K., and Shoval, N. (2015). Tourism Religion and Pilgrimage in Jerusalem (eds). New York: Routledge.\nCohen, E., Ifergan, M., Cohen, E. (2002). A New Paradigm in Guiding: the Madrich as a Role Model. Annals of Tourism Research. Vol.29. pp.919-932.\nPizam & Riechel, (1996). The Effect of Nationality on Tourist Behaviour: Israeli Tour Guides Perceptions. Journal of Hospitality and Leisure Marketing, Vol. 4 (1). pp.23-41.