jimnoneill/paper-to-field-training huggingface dataset:
Phylogenetic and pathogenic analysis of Indian isolates of Newcastle disease virus

Field: Veterinary (Health Sciences)

In the present study, Indian Newcastle disease virus (NDV) isolates UP/3 and UP/4 collected from suspected field samples were characterized to be velogenic by pathogenic and phylogenetic analysis. Phylogenetic analysis based on the nucleotide sequences of the F gene indicated that UP/3 and UP/4 isolates belong to genotype VII and genotype IV, respectively. These isolates possessed the amino acid sequence 112 R/K-R-QK/R-R-F 117 in the F0 cleavage site, which is typical of velogenic NDV pathotype. All the NDV strains analyzed have shown to have non-synonymous to synonymous base substitution rate in the F gene ranging between 0.074-0.197, demonstrating the presence of purifying selection. HN gene of the isolates was found to have an open reading frame encoding 571 amino acids. The deduced amino acid sequences of the HN glycoprotein revealed that the cysteine residues essential for intra-molecular disulphide bonds to stabilize the HN molecules, antigenic sites and key residues for receptor binding were all conserved in Indian isolates.
The higher algebra of weighted colimits

Field: Mathematics (Physical Sciences)

We develop a theory of weighted colimits in the framework of weakly bienriched $\infty$-categories, an extension of Lurie's notion of enriched $\infty$-categories. We prove an existence result for weighted colimits, study weighted colimits of diagrams of enriched functors, express weighted colimits via enriched coends, characterize the enriched $\infty$-category of enriched presheaves as the free cocompletion under weighted colimits, prove a Bousfield-Kan formula for weighted colimits and an enriched adjoint functor theorem and develop a theory of universally adjoining weighted colimits to an enriched $\infty$-category. Via the latter we construct for every presentably $\mathbb{E}_{k+1}$-monoidal $\infty$-category $\mathcal{V}$ for $1 \leq k \leq \infty$ and set $\mathcal{H}$ of weights a presentably $\mathbb{E}_k$-monoidal structure on the $\infty$-category of $\mathcal{V}$-enriched $\infty$-categories that admit $\mathcal{H}$-weighted colimits. Varying $\mathcal{H}$ this $\mathbb{E}_k$-monoidal structure interpolates between the tensor product for $\mathcal{V}$-enriched $\infty$-categories and the relative tensor product for $\infty$-categories presentably left tensored over $\mathcal{V}$. Studying functoriality in $\mathcal{H}$ we deduce that taking $\mathcal{V}$-enriched presheaves is $\mathbb{E}_k$-monoidal with respect to the tensor product on small $\mathcal{V}$-enriched $\infty$-categories and the relative tensor product on $\infty$-categories presentably left tensored over $\mathcal{V}.$ As key applications we construct for every $n \geq 1 $ and set $\mathcal{K}$ of $(\infty, n)$-categories a tensor product for $(\infty,n)$-categories that admit $\mathcal{K}$-indexed (op)lax colimits, a tensor product for Cauchy-complete $\mathcal{V}$-enriched $\infty$-categories and tensor products for (Cauchy complete) $n$-stable, $n$-additive and $n$-preadditive $(\infty,n)$-categories.
Measurement of Vapor–Liquid Equilibria for the Binary Mixture of Octafluoropropane and Hexafluoropropylene Oxide Containing Octafluorocyclobutane

Field: Chemistry (Physical Sciences)

Isothermal vapor–liquid equilibrium (VLE) data were measured for the binary systems of octafluoropropane + octafluorocyclobutane and hexafluoropropylene oxide + octafluorocyclobutane system at the temperature range from 263.15 K to 303.15 K. The experiments were carried out with a circulating-type equilibrium apparatus including online gas chromatography analysis. The VLE data were correlated well by the Peng–Robinson equation of state using the Wong–Sandler mixing rules involving the NRTL model. All the binary parameters of these systems and the average absolute deviations (AADs) in terms of saturated pressure and vapor phase composition between the experimental and calculated values are represented.
[Detection of beta-lactamase in samples obtained after tonsillectomy in children].

Field: Medicine (Health Sciences)

Production of beta-lactamase was detected using a microbiological assay (Guts test) in samples of tonsils, and by in Haemophilus growing from the same samples of both tonsils obtained from 30 children aged 2 to 13 years (18 aged < 6 years and 12 aged > or = 6 years). Two pieces from each tonsil, core and superficial, were studied. The procedure included direct microscopic examination of smears, and culture to identify Haemophilus, beta-haemolytic streptococci and Streptococcus pneumoniae. Guts test was positive in tonsillar tissue obtained from 26 children (14 aged < 6 years and 2 aged > or = 6 years) (p < 0.01). In 10 of them (9 aged < 6 years and 1 aged > or = 6 years) (p < 0.05) grew beta-lactamase producer Haemophilus influenzae. One to three varieties of Haemophilus could be found in 28 children (11 with H. influenzae = 5 beta-lactamase +, 8 with Haemophilus parainfluenzae = 3 beta-lactamase +); Group A, C, or G streptococci in 5 children, but no strain of Streptococcus pneumoniae. No difference could be demonstrated between core and superficial samples: beta-lactamase activity was positive in superficial samples from 26 children and core samples from 24. Almost all bacteria described grew from superficial as well as (slightly but no significantly less) from core samples.
Identification of Pollen Grains Morphology and Morphometry in Liliaceae

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Palynology, the study of pollen, had a big role in paleontology, archeology, and forensics. Pollens from different plants had different morphology, such as in Liliaceae. Scanning electron microscopy (SEM) was applied to observe the morphology of Liliaceae pollens. This study aimed to determine the pollen grains morphology and morphometry in Liliaceae. The descriptive qualitative research was used five different species from three genera as the sample, namely Hemerocallis fulva , Hemerocallis lilioasphodelus , Aloe vera , Lilium longiflorum , and Lilium candidum . Parameters measured in this study were the types of pollen sizes, pollen shape, aperture characteristic, and ornamentation type of exine. The results showed that in Liliaceae had various shapes of pollen grains, i.e., prolate (1.33-2 μm) and per-prolate (≥ 2 μm), as well as the pollen grains size, from minuta (10-25 μm in diameter) to medium (25-50 μm in diameter). Aperture characteristic of the pollen grains was monocolpate which has one colpus, and the ornamentation type of exine was reticulate patterns.
Eye tracking system

Field: Computer Science (Physical Sciences)

Robust, non-intrusive human eye tracking problem has been a fundamental and challenging problem for computer vision area. The aim of this project is to design and develop a real-time, robust, non-intrusive eye tracking system with human eye movement indication property using the movements of eye pupil. The eye-tracking algorithm, called EyeTracer, is implemented using the Continuously Adaptive Mean-Shift (CAMSHIFT) algorithm developed by Bradski, G. Human eye image captured by the webcam is detected using the CAMSHIFT algorithm which draws an ellipse around the circumference of the pupil and tracks its movement. EyeTracer is able to continuously track and determine the coordinates of the eye; texture and pictorial data can be recorded and saved for future analysis use. The results show that EyeTracer can deliver more than 85% of accuracy in tracking and determining eye’s movement and fixation.
Screening barnyard millet germplasm against grain smut (Ustilago panici-frumentacei Brefeld)

Field: Agricultural and Biological Sciences (Life Sciences)

Barnyard millet accessions (257) were inoculated with grain smut spores at anthesis stage during 2003. Seed produced on inoculated ear heads was sown in 2005 and resulting plants evaluated for ten morphological traits and grain smut incidence. The accessions were grouped into seven groups based on origin. The lowest mean grain smut incidence was recorded for advance breeding lines, while highest mean value was observed for Uttarakhand group. Genes determining grain yield and susceptibility to grain smut were at most loosely linked as evidenced by non-significant correlations between grain smut incidence and grain yield in six out of seven groups as well as whole collection. Smut resistance along with grain yield in barnyard millet can be enhanced by adopting proper breeding strategy; therefore, in segregating generations, selection should be carried out for both characters simultaneously.
Persisting Gaps in M-OUD Coverage at Post-Discharge Recovery Houses Necessitate our Continued Advocacy

Field: Health Professions (Health Sciences)

Effective treatment of opioid use disorder (OUD) must target both the medical and psychosocial aspects of a patient's condition. This, in turn, requires a collaboration between medical providers and social supports. We would like to illustrate a key difficulty in this collaboration for some patients in our country: many post-discharge recovery houses continue to refuse to allow patients to remain on medication treatment for OUD (M-OUD). This barrier to M-OUD access in recovery houses is a significant obstacle to effective OUD treatment.
Effects of a transitional home-based care program for stroke survivors in Harbin, China: a randomized controlled trial

Field: Health Professions (Health Sciences)

Abstract Background China has the biggest stroke burden in the world. Continued measures have been taken to enhance post-stroke rehabilitation management in the last two decades. The weak link is with home-based rehabilitation, with more attention and resources devoted to inpatient rehabilitation. Objective to address the service gap, this study tested a home-based transitional care model for stroke survivors. Methods a randomized controlled trial was conducted from February 2019 to May 2020 in Harbin, China, involving 116 patients with ischemic stroke. The intervention group participants (n = 58, 50%) received a 12-week home-based care program with components of transitional care measures and the national guidelines for facilitating patients to perform home-based exercises with continued monitoring and gradual progression. Control group participants received standard care including medication advice, rehabilitation exercise and one nurse-initiated follow-up call. Data were collected at baseline and after a 90-day (post-intervention) and a 180-day (post-intervention) follow-up. The primary outcome was quality of life (QOL), measured using the EuroQol-Five Dimension 5-Level scale (EQ-5D-5L). Results both intervention and control groups showed improvement in EQ-5D-5L from baseline to post-intervention (0.66 versus 0.83, P &lt; 0.001) and (0.66 versus 0.77, P &lt; 0.001), respectively, and there was significant group-by-time interaction in EuroQol-Visual Analogue Scale from baseline to post-intervention at 90 days and follow-up at 180 days with the intervention group experiencing better improvement. Similarly, significant interaction effects were also found in the Stroke Impact Symptom scale, self-efficacy and modified Barthel Index. Conclusions home-based transitional care was effective in improving QOL, symptoms, self-efficacy and activities of daily living.
Biostratigraphy of Lower Cretaceous Blake Nose and Blake-Bahama Basin Foraminifers, DSDP Leg 44, Western North Atlantic Ocean

Field: Earth and Planetary Sciences (Physical Sciences)

Deep Sea Drilling Project Sites 390 and 392, Blake Nose, penetrated about 30 meters of nannofossil ooze and limestone rich in excellently preserved Lower Cretaceous planktonic (over 12 taxa) and benthic (over 50 taxa) foraminifers.Range charts are presented and four standard planktonic zones and one benthic zone are recognized which allow a detailed regional correlation.Drilling at DSDP Site 391 (Blake-Bahama Basin) penetrated about 400 meters of dark and variegated claystone and light limestone and shale with sparse, poorly preserved foraminifers assigned to four assemblages or zones, comprising Valanginian, Barremian, Aptian-Albian, and Upper Cretaceous sediments.One assemblage zone (Dorothiapraehauteriviana) correlates Site 391 to Sites 101 and 105, DSDP Leg 11; another (Plectorecurvoides assemblage zone) may be diagnostic for the dark and variegated claystone facies both in the Atlantic and in the Pacific oceans.The taxonomy and stratigraphic ranges of over 50 taxa are discussed and figured.Attention is focused on the intraspecific variation within the plexus Gavelinella-Lingulogavelinella on the basis of three previously described forms.Phylogenetic trends in the group of Gaudryina dividens-Spiroplectinata are more complicated than previously established.
Adaptive Finite-Time Containment Control of Uncertain Multiple Manipulator Systems

Field: Engineering (Physical Sciences)

This article is concerned with the containment control of multiple manipulators with uncertain parameters. A novel distributed adaptive backstepping strategy is given in the finite-time control framework. The finite-time command filters (FTCFs) used in the strategy can avoid the explosion of complexity problem for conventional backstepping. To further improve the control performance, the filtering errors caused by the used FTCFs are removed by using the error compensation mechanism (ECM). The proposed virtual control signal, the control torque, and the adaptive updating law can guarantee the set tracking errors converge to an adjustable neighborhood of the origin in finite time in the presence of uncertain parameters. Because the virtual control signal and ECM only use the local information, the established method is completely distributed. Two simulation examples are given to show the effectiveness of the proposed scheme.
Brain-Penetrating Peptide Shuttles Across the Blood-Brain Barrier and Extracellular-like Space

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Here, we describe a combinatorial approach to identify peptide shuttles that successfully traverse the multiple barriers to systemic drug delivery to the brain--1. the blood-brain barrier (BBB) and the 2. extracellular space (ECS) of the brain. Leveraging the excellent molecular diversity of M13 phage libraries, we identified peptides that actively transport across the BBB and diffuse through the extracellular matrix of the ECS in cell culture and in mice. These peptides demonstrate higher accumulation in the brain than gold standard peptides used in clinical trials. Importantly, these findings suggest that different sized therapeutics that were previous poorly permeable into the brain can accumulate at higher concentrations, thereby improving the therapeutic index and ultimate efficacy of drugs into the brain.
Reseña del libro (Re)pensando el vínculo entre migración y crisis: un análisis crítico desde la interseccionalidad y la estigmatización de las movilizaciones humanas

Field: Social Sciences (Social Sciences)

Migration as a global phenomenon has undergone a series of transformations over time. These changes include the causes of migration, as well as the perceptions generated when addressing it as a contemporary challenge. Regarding the current conception of migration as a risk for today's societies, Lucila Nejamkis, Luisa Conti and Mustafa Aksakal propose to open the discussion on the links between human displacement and what is called crisis in their book "(Re)pensando el vínculo entre migración y crisis: un análisis crítico desde la interseccionalidad y la estigmatización de las movilizaciones humanas" published in 2021. The book comprises twelve case studies which are distributed in three categories: politics, environment and identities. Thus, the chapters are grouped in such a way as to cover the multiple dimensions of migration while at the same time making visible recurrent problems suffered by migrants and impacting different levels of society.
Effect of Fertilizer and Moisture on Seed Yield of Onion

Field: Agricultural and Biological Sciences (Life Sciences)

Inbred onions, Allium cepa L, were grown with different levels of fertilizer and soil. moisture to determine treatment influence on seed yield. Nitrogen (253 kg/ha) alone or in combination with P (162 kg/ha> reduced plant survival, umbels per plant, pollination index, and seed yield where soil moisture was low but the reduction was nil. or not as severe where soil moisture was high.
Data from The Predictive and Prognostic Value of Early Metabolic Response Assessed by Positron Emission Tomography in Advanced Gastric Cancer Treated with Chemotherapy

Field: Medicine (Health Sciences)

<div>Abstract<p><b>Purpose:</b> To evaluate the feasibility of early metabolic change assessed by PET in predicting clinical response to chemotherapy and investigate its prognostic value in patients with advanced gastric cancer.</p><p><b>Experimental Design:</b> A total of 64 patients with advanced gastric cancer were prospectively enrolled and examined by PET with <sup>18</sup>F-fluorodeoxyglucose (FDG) and <sup>18</sup>F-fluoro-3′-deoxy-3′-L-fluorothymidine (FLT) at baseline and 14 days after treatment initiation. PET findings were analyzed for the correlation with best clinical response of patients, disease control status, and survival after identifying the threshold of metabolic change percentage by ROC analysis.</p><p><b>Results:</b> For FDG-PET, the total uptake value reduction percentage (δ-SUV) of 40% was the cut-off point with the maximum of sensitivity (70%) and specificity (83%) to predict clinical responding and that of prediction for disease control status was 30%, with the highest sensitivity (58%) and specificity (100%). The δ-SUV of FLT-PET played no predictive role for clinical response (AUC = 0.62; <i>P</i> = 0.134) and disease control (AUC = 0.66; <i>P</i> = 0.157). The univariate Cox regression analysis revealed no significant prognostic impact. FDG uptake reduction in liver metastases could predict both clinical response (<i>P</i> = 0.010) and disease control status (<i>P</i> = 0.002) at thresholds of 35% and 15%, respectively. Those with greater FDG uptake reduction in liver lesions had a longer overall survival (<i>P</i> = 0.004).</p><p><b>Conclusions:</b> Early metabolic change in FDG-PET might be a predictive marker for response and disease control in advanced gastric cancer. Early FDG uptake change in liver metastases might be a useful prognostic factor and needs further exploration. <i>Clin Cancer Res; 22(7); 1603–10. ©2015 AACR</i>.</p></div>
Figure S7 from Inactivation of <i>NF1</i> Promotes Resistance to EGFR Inhibition in <i>KRAS/NRAS/BRAF<sup>V600</sup></i>-Wild-Type Colorectal Cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>Figure S7. Quantification of colony assays from Figure 5D.</p>
Aberrant Expression of GABA-Related Genes in the Hippocampus of 3xTg-AD Model Mice from the Early to End Stages of Alzheimer’s Disease

Field: Neuroscience (Life Sciences)

Background: We explored the gene expression levels in the brain of 3xTg-AD model mice to elucidate the molecular pathological changes from the early to end stages of Alzheimer’s disease (AD). Objective: We re-analyzed our previously published microarray data obtained from the hippocampus of 3xTg-AD model mice at 12 and 52 weeks of age. Methods: Functional annotation and network analyses of the up- and downregulated differentially expressed genes (DEGs) in mice aged 12 to 52 weeks were performed. Validation tests for gamma-aminobutyric acid (GABA)-related genes were also performed by quantitative polymerase chain reaction (qPCR). Results: In total, 644 DEGs were upregulated and 624 DEGs were downregulated in the hippocampus of both the 12- and 52-week-old 3xTg-AD mice. In the functional analysis of the upregulated DEGs, 330 gene ontology biological process terms, including immune response, were found, and they interacted with each other in the network analysis. In the functional analysis of the downregulated DEGs, 90 biological process terms, including several terms related to membrane potential and synapse function, were found, and they also interacted with each other in the network analysis. In the qPCR validation test, significant downregulation was seen for Gabrg3 at the ages of 12 ( p = 0.02) and 36 ( p = 0.005) weeks, Gabbr1 at the age of 52 weeks ( p = 0.001), and Gabrr2 at the age of 36 weeks ( p = 0.02). Conclusion: Changes in immune response and GABAergic neurotransmission may occur in the brain of 3xTg mice from the early to end stages of AD.
[Multicomponent antithrombotic effect of the neuroprotective prolyl dipeptide GVS-111 and its major metabolite cyclo-L-prolylglycine].

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The experiments in vivo showed that the new nootropic prolyl-containing GVS-111 produces an antithrombotic effect, influencing various stages of the blood coagulation process. GVS-111 exhibits anticoagulant and fibrinolytic properties and enhances fibrin destabilization by reducing the XIIIa factor activity. These effects are manifested upon both intraperitoneal (1 mg/kg) and peroral (10 mg/kg) administration of GVS-111 (in both cases, a single daily treatment over a period of 10 days). The same effects (anticoagulant, fibrinolytic, antifibrin-stabilizing) were observed in in vitro experiments with both GVS-111 (10(-3)-10(-6) M) and its main metabolite cyclo-L-prolylglycine (up to 10(-10) M). In addition, the latter metabolite exhibited an antiaggregant effect. The antithrombotic activity of GVS-111, together with previously established neuroprotector properties, low toxicity, and the absence of complications, makes this compound a promising antistroke drug.
The Suture of an Allusion: Lacan with Leon Bloy

Field: Arts and Humanities (Social Sciences)

Toward the end of the first volume of his seminars to be published, Les Quatre concepts fondamentaux de la psychanalyse, at the foundation, then, of his return to Jacques Lacan offers surprisingly egregiously inappropriate allusion to the book that Leon Bloy regarded as the most considerable of his works, Le Salut par les juifs. Lacan: donc, vous l'ai-je represent6 la derniere fois telle la figure d'Abraham, d'Isaac et de Jacob? Leon Bloy, dans Salut par les juifs, les incarne sous la forme de trois %galement vieillards qui sont 1a, selon une des formes de la vocation d'Israel, se livrant, autour de je ne sais quelle' bache, cette occupation fondamentale qui s'appelle la brocante. II (sic) trient. Il y une chose qu'ils mettent d'un c6to, et une autre, de l'autre. Freud, d'un c6te met les pulsions partielles, et de l'autre l'amour. II dit c'est pas pareil.I C'est pas pareil: one would expect, then, for the analogy to hold, that Bloy would evoke the discriminatory talent of the Jewish tinkerer or merchant, sorting out items even as Freud would distinguish between partial impulses or drives and genital love subordinfated to the needs and delusions of the ego. Indeed, given the simplicity or flatness of the comparison, one might even imagine Lacan less attracted by the image than by the title of the book Le Salut par les juifs insofar as it epitomized the program of psychoanalysis in its early phase. Freud, it will be recalled, observed, with misgiving, in letter to Abraham, that psychoanalysis was becoming a Jewish national affair ....2 Whence call for indulgence toward the Swiss ... Yet no sooner does one glance at the passage in Bloy to which Lacan alludes, than one realizes the enormity of the psychoanalyst's apparent error. For Bloy's purpose is to recount the degree of moral and physical abjection to which humanity has descended in the figure of the Jew: le Youtre moderne parait &tre confluent de toutes les hideurs du monde (p. 29). He evokes the Jewish market in Hamburg, the almost physical malaise which he felt at the obsequiousness of the merchants, the