jimnoneill/paper-to-field-training huggingface dataset:
Abstract 6647: Targeting DCLK1-mediated glutamine addiction in chemoresistant ovarian cancer

Field: Medicine (Health Sciences)

Ovarian cancer (OC) presents significant therapeutic challenges due to its frequent late-stage diagnosis accompanied by distant metastases and the development of chemoresistance. As existing FDA-approved targeted therapies for OC do not adequately address peritoneal metastases, there is an urgent need for innovative treatment strategies that specifically target the molecular and cellular pathways underlying metastasis and disease recurrence. Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase with a demonstrated role in cancer cell stemness, epithelial-mesenchymal transition (EMT), disease progression in gastrointestinal and pancreatic cancers and resistance in ovarian and lung cancer. The study objective is to evaluate the functional role of DCLK1 in the peritoneal metastasis of OC and investigate the associated benefits of antagonizing it as a novel strategy to mitigate OC metastasis. Our prior studies demonstrate DCLK1 inhibition reduces the number of visible metastases in an orthotopic OC model in mice. In this study, we used pharmacological inhibition (DCLK1-IN-1), and genetic manipulation (DCLK1 CRISPR-knockout (KO) and over-expression systems) to assess the role of DCLK1 in promoting OC metastasis. We observed that elevated DCLK1 expression enhanced OC cell adhesion to different extracellular matrices including collagen, fibronectin, and laminin. Furthermore, DCLK1 inhibition effectively reduced mesothelial cell clearance relative to control. Targeted gene expression profiling and pathway analysis revealed DCLK1 inhibition in cisplatin resistant (CPR) OC spheroids upregulated genes involved in glutamine metabolism. Using metabolic flux assays, we demonstrated increased oxygen consumption in DCLK1 KO CPR cells that was abrogated by BPTES (glutamine oxidation inhibitor). Furthermore, we show that combined treatment of OC CPR spheroids with DCLK1 inhibitor (DCLK1-IN-1) and glutamine antagonist (DRP-104) showed a synergistic cytotoxic effect. In addition, the novel combination strategy was significantly effective in reducing OC cell adhesion and mesothelial cell clearance relative to single agent alone. Collectively, our findings establish DCLK1 as a key regulator of metastasis and demonstrate that its inhibition induces glutamine dependency in chemoresistant tumor cells. Thus, the combined use of DCLK1 inhibitors (e.g., DCLK1-IN-1) with glutamine metabolism inhibitors (e.g., DRP-104) represents a rational therapeutic approach to mitigate peritoneal metastases in a chemoresistant setting. Citation Format: Samrita Dogra, Cole Hladik, Sugantha Priya Elayapillai, Bethany Hannafon. Targeting DCLK1-mediated glutamine addiction in chemoresistant ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 6647.
[Defense mechanisms].

Field: Psychology (Social Sciences)

Defence mechanisms are mental operations that are involuntary and unconscious and contribute to reduce internal and external stresses. The concept of defensive organisation or style, defined as a set of defence mechanisms relatively stable and characteristic of personality appears to be a major dimension of personality, from normal to pathology. Studies on defence mechanisms have gained the interest of clinicians, largely outside the psychoanalytical field. However, the lack of reliability and validity of the assessment instruments still limits the empirical studies of the relation between defence mechanisms and psychological health as well as of their therapeutic implications.
Supplementary material 6 from: Vasiliţa C, Popovici OA, Talamas E, Johnson N, Masner L, Tortorici F, Fusu L (2021) Molecular analysis reveals Latonius planus Kononova to be a derived species of Trissolcus Ashmead. In: Lahey Z, Talamas E (Eds) Advances in the Systematics of Platygastroidea III. Journal of Hymenoptera Research 87: 267-289. https://doi.org/10.3897/jhr.87.63533

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Nexus alignment of the dataset from Talamas et al. (2019) including Trissolcus planus
Conversation-driven Social Media Optimization : Tactic and Effects on User Engagement

Field: Business, Management and Accounting (Social Sciences)

Creating engaging social media content remains the biggest challenge in digital marketing. Lack of framework and user-centric approach may contribute to campaign’s ineffectiveness in fostering user engagement. This research introduces Conversation-driven Social Media Optimization (SMO), a two-steps tactic as the solution. Twitter was used as the media, and Indonesian tourism was used as the context. In Conversation Mining and Analysis step, optimized words from the most popular (“Temple” topic) and least popular conversation (“Surfing” topic) in Twitter were gauged. Later, were used to construct digital contents (listicle, photo gallery, videos) in the Conversation Steering step. Evaluative experiment revealed that using the tactic in content creation has significant effect on user engagement, most importantly word-of-mouth intention. Enthusiasm to travel moderated the effects. Yet, the effect does not depend on inherent engaging level of the content. Lastly, video with optimized words from most popular conversation was proven to the most effective content.
Nearfield Fourier transform imaging

Field: Computer Science (Physical Sciences)

The two-dimensional Fourier transform provides an efficient method of forming beams for a line array. The field as sampled by the evenly spaced array is the Fourier transform of the farfield source. Its resolution is limited by the receiving aperture and the signal-to-noise ratio at the array elements. When the field is stationary, the resolution can be increased by integrating the Fourier transforms magnitude squared. If the field is also homogeneous the resolution can be increased by extending the aperture without adding additional elements by the method described by Nuttall et al. This method constructs the two-dimensional spectrum of objects in the farfield without grating lobes from the cross spectra of elements of the array. The array spacings must all be multiples of a basic spacing in order to make the calculation efficient. The method has been extended to apply to objects in the nearfield as well, and allows estimation of noise measured in the nearfield with sparce arrays with an efficient computer program.
Comment on cp-2023-26

Field: Medicine (Health Sciences)

Abstract. The study examines the relationship between temperature values and precipitation rates as explanatory variables and the probability of death due to waterborne, airborne, and other diseases in historical urban space. So far, the literature has not been focused on epidemiology of 19th -century Polish urban areas in climatological context. We used individual data on mortality from Poznań parish death registers for 1850–1900. Each deceased individual was assigned the average monthly temperature values and precipitation rates in the month of death, LAG1 temperature and LAG1 rainfall, and a quarter of residence. We studied the relationship between weather conditions and mortality using formalized statistical models reflecting the discrete nature of the response data (via multinomial logistic regression). Lagged monthly average temperature values and lagged monthly average precipitation rates were better predictors of airborne and waterborne disease mortality than the concurrent (non-lagged) monthly averages. The lagged effects of temperature and precipitation on waterborne and airborne diseases were significant (except for the smooth lagged average monthly temperature effect for airborne diseases). There was also significant spatial heterogeneity (differences among city quarters) in the prevalence of deaths due to waterborne and airborne diseases.
Grass pasture and hay field herbicides

Field: Agricultural and Biological Sciences (Life Sciences)

GRASS PASTURE AND HAY FIELD HERBICIDES Tim R. Murphy, Extension Agronomist-Weed Science February 2011 For many years, 2,4-D (several trade names), dicamba (Vanquish, Banvel) and 2,4-D + dicamba (WeedMaster, other trade names) were the primary herbicides used for broadleaf weed control in pastures and hay fields. While these products are still valuable components of broadleaf weed management, several new herbicides have been registered in recent years for weed control in pastures and hayfields. The following is a discussion of the characteristics and uses of these herbicides.
Pharmacist-initiated management of antiretroviral therapy (PIMART)

Field: Health Professions (Health Sciences)

We the undersigned, a collective of pharmacy \nresearchers, practitioners and academics, call on the Minister to \nconsider the following points in response to the input made by the \nSouth African Medical Association (SAMA) in relation to pharmacist-initiated management of antiretroviral therapy (PIMART), dated 9 \nSeptember 2021. We wish to highlight the expertise of pharmacists \nin all matters relating to the design, production and use of quality, \nsafe and affordable medicines. Furthermore, we need to stress the \nincreasing importance of and role played by pharmacists in primary \ncare teams, which has been further reinforced during the COVID-19 \npandemic and subsequent vaccination efforts.
Remote Sensing and Modeling LENA2006.

Field: Environmental Science (Physical Sciences)

Quantifying sources and sinks of climatological relevant trace gases as well as understanding their exchange between atmosphere and land surfaces has become essential research topics in atmospheric sciences during the last years. High latitude ecosystems are most critically influenced by a changing climate. Modeling the terrestrial carbon cycle - net CO2 uptake by vegetation (Net Primary Productivity, NPP) as well as methane emissions from natural wetlands – is a powerful tool to study the impact of climate change. Uncertainties in the carbon budget of arctic ecosystems remain partly due to difficulties in assessing the spatially and temporally highly variable methane emissions of permafrost soils.
Lectin receptor proximity on HL‐60 leukemia cells determined by fluorescence energy transfer using flow cytometry

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Fluorescence energy transfer using flow cytometric measurements was utilized to determine the proximity of concanavalin A receptors on the surface of HL‐60 promyelocytic leukemia cells before and after induction of differentiation. The HL‐60 cells were induced to differentiate into granulocytes using dimethylsulfoxide and into macrophages using 12‐O‐tetradecanoylphorbol‐13‐acetate. Concanavalin A was labeled with either fluorescein (donor chromophore) or tetramethylrhodamine (acceptor chromophore), and these species were used to determine lectin proximity. With granulocytic differentiation, the amount of concanavalin A bound remained constant, but a decrease in receptor density was observed. During macrophage differentiation, however, both receptor density and receptor number increased. The increase in concanavalin A binding during differentiation appears to be a result of maturation rather than an initiating event.
Rapid Detection of Anti-SARS-CoV-2 Antibodies with a Screen-Printed Electrode Modified with a Spike Glycoprotein Epitope

Field: Medicine (Health Sciences)

Background: The coronavirus disease of 2019 (COVID-19) is caused by an infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was recognized in late 2019 and has since spread worldwide, leading to a pandemic with unprecedented health and financial consequences. There remains an enormous demand for new diagnostic methods that can deliver fast, low-cost, and easy-to-use confirmation of a SARS-CoV-2 infection. We have developed an affordable electrochemical biosensor for the rapid detection of serological immunoglobulin G (IgG) antibody in sera against the spike protein. Materials and Methods: A previously identified linear B-cell epitope (EP) specific to the SARS-CoV-2 spike glycoprotein and recognized by IgG in patient sera was selected for the target molecule. After synthesis, the EP was immobilized onto the surface of the working electrode of a commercially available screen-printed electrode (SPE). The capture of SARS-CoV-2-specific IgGs allowed the formation of an immunocomplex that was measured by square-wave voltammetry from its generation of hydroquinone (HQ). Results: An evaluation of the performance of the EP-based biosensor presented a selectivity and specificity for COVID-19 of 93% and 100%, respectively. No cross-reaction was observed to antibodies against other diseases that included Chagas disease, Chikungunya, Leishmaniosis, and Dengue. Differentiation of infected and non-infected individuals was possible even at a high dilution factor that decreased the required sample volumes to a few microliters. Conclusion: The final device proved suitable for diagnosing COVID-19 by assaying actual serum samples, and the results displayed good agreement with the molecular biology diagnoses. The flexibility to conjugate other EPs to SPEs suggests that this technology could be rapidly adapted to diagnose new variants of SARS-CoV-2 or other pathogens.
The impact of workplace bullying on individual and organisational well-being in a South African context and the role of coping as a moderator in the bullying-well-being relationship.

Field: Psychology (Social Sciences)

The aim of the present study was to determine the impact of workplace \nbullying on individual and organisational outcomes. Additionally the study \nattempted to determine the moderating effects of four coping strategies due \nto the effects of workplace bullying on the individual, namely, seeking help, \navoidance, assertiveness and doing nothing. The Negative Acts \nQuestionnaire-Revised was used to assess the perceptions of workplace \nbullying within a construction company. A coping scale measuring the four \ncoping strategies proposed, and which relates to the subject of workplace \nbullying, was modified and validated on a South African sample. The \nanalyses used for the study was that of moderated multiple regression. The \npurpose was to determine the main effects of workplace bullying on the \ndependent variables, namely, psychological well-being, self esteem, job \nsatisfaction and intention to leave. Secondly, it was used to assess the \nmoderating effects of the four coping strategies on the dependent variables \ndue to the impact of workplace bullying. The results reported main effects for \nworkplace bullying on the dependent variables, however inverse relationships \nwere reported for workplace bullying on job satisfaction and intention to \nleave. Secondly, an interaction effect for all four of the coping strategies on \npsychological well-being was reported, although inverse relationships were \nfound for the coping strategies of avoidance and doing nothing on \npsychological well-being. Furthermore, an interaction effect for the coping \nstrategy of avoidance was reported for self esteem. Direct effects were \nreported between the coping strategy of seeking help and psychological wellbeing, \nas well as between the coping strategy of avoidance and job \nsatisfaction, albeit the latter was inverse in nature. Confounding variables \nwere also assessed in order to account for any spuriousness within the data. \nThe covariate of race demonstrated a significant, yet inverse effect on \nintention to leave. No moderating effects for job satisfaction and intention to \nleave were reported. A discussion of these findings, the limitations of the \nresearch and theoretical implications of the present study are noted. In \naddition, advances made by the present research towards a greater \nunderstanding of workplace bullying and coping within South Africa are \nacknowledged. Furthermore, recommendations for future research on \nworkplace bullying and coping are elaborated on.
Trigger efficiencies of BATSE and PVO

Field: Physics and Astronomy (Physical Sciences)

Observed distributions of GRB fluxes or V/V{sub max}, at low equivalent intensities, affected by detection threshold effects. Therefore it is difficult to properly interpret the equivalent low-intensity ends of these distributions without careful evaluation of these effects. In this paper, we present results of calculations of the trigger efficiencies of BATSE and PVO as a function of burst peak flux. These efficiencies take into account all trigger conditions, typical burst characteristics and {gamma}-ray background conditions. We find a strong dependence of trigger efficiency on the GRB time profiles. We briefly discuss the implications that this has for the observed GRB peak flux distribution. Although our assessment of the trigger efficiency is not yet comprehensive, it clearly indicates the care one should consider in the interpretation of the GRB data set.
B-GAP: Behavior-Rich Simulation and Navigation for Autonomous Driving

Field: Computer Science (Physical Sciences)

We address the problem of ego-vehicle navigation in dense simulated traffic environments populated by road agents with varying driver behaviors. Navigation in such environments is challenging due to unpredictability in agents' actions caused by their heterogeneous behaviors. We present a new simulation technique consisting of enriching existing traffic simulators with behavior-rich trajectories corresponding to varying levels of aggressiveness. We generate these trajectories with the help of a driver behavior modeling algorithm. We then use the enriched simulator to train a deep reinforcement learning (DRL) policy that consists of a set of high-level vehicle control commands and use this policy at test time to perform local navigation in dense traffic. Our policy implicitly models the interactions between traffic agents and computes safe trajectories for the ego-vehicle accounting for aggressive driver maneuvers such as overtaking, over-speeding, weaving, and sudden lane changes. Our enhanced behavior-rich simulator can be used for generating datasets that consist of trajectories corresponding to diverse driver behaviors and traffic densities, and our behavior-based navigation scheme can be combined with state-of-the-art navigation algorithms.
Cholinergic Crisis Owing to Distigmine Bromide Complicated by Hyperosmolar Hyperglycemic State

Field: Medicine (Health Sciences)

Distigmine bromide is widely used to treat neurogenic bladder and causes cholinergic crisis, a serious side effect. We herein report about a patient with distigmine bromide-induced cholinergic crisis complicated by a hyperosmolar hyperglycemic state (HHS). On admission, the patient was diagnosed with HHS based on the medical history and laboratory test results. However, she also had bradycardia, miosis, and low plasma cholinesterase activity. We later found that she had received distigmine bromide, which led to a diagnosis of cholinergic crisis. We suggest that the exacerbation of pathology, including HHS, can cause cholinergic crisis in patients receiving distigmine bromide.
Multiple organ failure: whole body inflammation?

Field: Medicine (Health Sciences)

Inventarising the inflammatory capacities of the three types of inflammatory cells, PMN, macrophages and mast cells, each type seems able to induce a lethal whole body reaction. This whole body inflammation has hitherto largely escaped our attention, as in clinical studies inappropriate methods have been used such as counting peripheral leucocytes, and as monitoring key-mediators (IL-1, TNF, PGE-2, leukotrienes) and key-cells (activated PMN, macrophages and mast cells) hitherto was impossible. Presently a new set of methods is available, allowing a closer look at this whole body inflammation, such as elastase (monitoring PMN activity), neopterin (monitoring macrophage activity) and hopefully clinically practicable methods to monitor cytokines as well as endotoxin-levels. Only after such comprehensive studies have been performed, it might be concluded that--as in the experimental animal--sepsis and MOF may not necessarily be caused by bacteria or their endotoxins, but by an untoward autodestructive and self-sustaining activation of angry leucocytes and mad macrophages.
A Search Engine Concept to Improve Food Traceability and Transparency: Preliminary Results

Field: Agricultural and Biological Sciences (Life Sciences)

In recent years, the digital revolution has involved the agrifood sector. However, the use of the most recent technologies is still limited due to poor data management. The integration, organisation and optimised use of smart data provides the basis for intelligent systems, services, solutions and applications for food chain management. With the purpose of integrating data on food quality, safety, traceability, transparency and authenticity, an EOSC-compatible (European Open Science Cloud) traceability search engine concept for data standardisation, interoperability, knowledge extraction, and data reuse, was developed within the framework of the FNS-Cloud project (GA No. 863059). For the developed model, three specific food supply chains were examined (olive oil, milk, and fishery products) in order to collect, integrate, organise and make available data relating to each step of each chain. For every step of each chain, parameters of interest and parameters of influence—related to nutritional quality, food safety, transparency and authenticity—were identified together with their monitoring systems. The developed model can be very useful for all actors involved in the food supply chain, both to have a quick graphical visualisation of the entire supply chain and for searching, finding and re-using available food data and information.