jimnoneill/paper-to-field-training huggingface dataset:
Efficacy and safety of prolonged‐release tacrolimus in stable pediatric allograft recipients converted from immediate‐release tacrolimus – a Phase 2, open‐label, single‐arm, one‐way crossover study

Field: Medicine (Health Sciences)

There are limited clinical data regarding prolonged-release tacrolimus (PR-T) use in pediatric transplant recipients. This Phase 2 study assessed the efficacy and safety of PR-T in stable pediatric kidney, liver, and heart transplant recipients (aged ≥5 to ≤16 years) over 1 year following conversion from immediate-release tacrolimus (IR-T), on a 1:1 mg total-daily-dose basis. Endpoints included the incidence of acute rejection (AR), a composite endpoint of efficacy failure (death, graft loss, biopsy-confirmed AR, and unknown outcome), and safety. Tacrolimus dose and whole-blood trough levels (target 3.5-15 ng/ml) were also evaluated. Overall, 79 patients (kidney, n = 48; liver, n = 29; heart, n = 2) were assessed. Following conversion, tacrolimus dose and trough levels remained stable; however, 7.6-17.7% of patients across follow-up visits had trough levels below the target range. Two (2.5%) patients had AR, and 3 (3.8%) had efficacy failure. No graft loss or deaths were reported. No new safety signals were identified. Drug-related treatment-emergent adverse events occurred in 28 patients (35.4%); most were mild, and all resolved. This study suggests that IR-T to PR-T conversion is effective and well tolerated over 1 year in pediatric transplant recipients and highlights the importance of therapeutic drug monitoring to maintain target tacrolimus trough levels.
Formal Justice and Rule-Change: A Reply to Holborow

Field: Arts and Humanities (Social Sciences)

Formal Justice and Rule-Change: A Reply to Holborow Get access T. D. Campbell T. D. Campbell University of Stirling Search for other works by this author on: Oxford Academic Google Scholar Analysis, Volume 35, Issue 1, October 1974, Pages 19–21, https://doi.org/10.1093/analys/35.1.19 Published: 01 October 1974
FACTORS AND CAUSES THAT INFLUENCE THE SPRINGBACK INTENSITY IN THE CASE OF CYLINDRICAL AND CONICAL DRAW PARTS MADE FROM STEEL SHEETS

Field: Engineering (Physical Sciences)

The cold plastic forming of metal sheets generates a undesired phenomenon known as springback. Springback occurs after the tools were removed and the forming forces become equal to zero – and leads to a shape of the final part different from the theoretical ones. The study and analysis of the factors that influence this phenomenon is useful for the accurate design of the forming processes and forming tools. The present paper performs an analysis of the factors that influence the springback phenomenon in the case of the cylindrical and conical drawn parts made from steel sheets.
CONTROL SOFTWARE FOR A PROGRAMMABLE SOUNDFIELD CONTROLLER

Field: Computer Science (Physical Sciences)

This paper describes software which was designed to control various lorrns oi Ambisonic sound image manipulation in real time, using a mouse pointer control interface.The sottware runs on an Atari ST computer and drives external hardware to control the actual audio signals.Non Ambisonic sources can be processed into Ambisonic B40rmat ones and 3-1th signals can be iurther modi ed.
Combination of GNSS and VLBI data for consistent estimation of Earth Rotation Parameters

Field: Earth and Planetary Sciences (Physical Sciences)

&lt;p&gt;We present the current activities of the Federal Agency for Cartography and Geodesy (BKG) towards a combined processing of VLBI and GNSS data.&amp;#160; The main goal of the combined analyses of the two different space-geodetic techniques is the improvement of the consistency between the techniques through common parameters, i.e., mainly Earth Rotation Parameters (ERPs), but also station coordinates and tropospheric parameters through local ties and atmospheric ties, respectively.&lt;/p&gt;&lt;p&gt;Based on our previous combination studies using GNSS data and VLBI Intensive sessions on a daily and multi-day level, we generate a consistent, low-latency ERP time series with a regular daily resolution for polar motion and dUT1. We achieved in this way a significant accuracy improvement of the dUT1 time series and a slight improvement of the pole coordinates time series, comparing ERPs from the combined processing with the individual technique-specific ERPs.&lt;/p&gt;&lt;p&gt;In our recent studies, we extend the combination of GNSS and VLBI Intensive sessions by adding VLBI 24-hour sessions in order to exploit the benefit of the combination to its maximum extend. We analyse the impact of the combination on the global parameters of interest, i.e., mainly dUT1, polar motion and LOD, but also on station coordinates.&lt;/p&gt;&lt;p&gt;BKG&amp;#8217;s primary interest is the combination of GNSS and VLBI data on the observation level. However, the current combination efforts are based on the normal equation level using technique-specific SINEX files as a starting point.&lt;/p&gt;
Hybrid – Can That Be My Nickname?: Intersectionality, Afro-Nihilism, And The Otherly Existence Of Queer Black Women

Field: Social Sciences (Social Sciences)

For Black women, recognizing, accessing, and exercising their ability to disrupt hegemonic categories of normativity is an important project. A combination of misogyny/sexism and racism relegates all Black women in America to an intersecting space of multiple marginalizations, and Black masculine lesbians ultimately occupy a space in the intersection of no less than four different oppressions: race, gender, sexuality, and gender nonconformity. This project examines, through narrative inquiry – primarily the poetic of storytelling – the ways that Black masculine lesbians, due to their particular positionality, experience an alternative, Otherly ontological existence. It also investigates the ways in which Black masculine women navigate, and ultimately transgress and subvert white heteropatriarchal standards of masculinity while concurrently creating an alternative space of performance within which they navigate/resist violence and access personal power.
Methods for Characterizing the Co-development of Biofilm and Habitat Heterogeneity

Field: Immunology and Microbiology (Life Sciences)

Biofilms are surface-attached microbial communities that have complex structures and produce significant spatial heterogeneities. Biofilm development is strongly regulated by the surrounding flow and nutritional environment. Biofilm growth also increases the heterogeneity of the local microenvironment by generating complex flow fields and solute transport patterns. To investigate the development of heterogeneity in biofilms and interactions between biofilms and their local micro-habitat, we grew mono-species biofilms of Pseudomonas aeruginosa and dual-species biofilms of P. aeruginosa and Escherichia coli under nutritional gradients in a microfluidic flow cell. We provide detailed protocols for creating nutrient gradients within the flow cell and for growing and visualizing biofilm development under these conditions. We also present protocols for a series of optical methods to quantify spatial patterns in biofilm structure, flow distributions over biofilms, and mass transport around and within biofilm colonies. These methods support comprehensive investigations of the co-development of biofilm and habitat heterogeneity.
Significados de familia para familias contemporáneas

Field: Social Sciences (Social Sciences)

(analytical)Given the existence of different types of families, and with the aim of understanding the meaning that human beings give to the diverse expressions of family that currently exist, a qualitative narrative study using semi-structured interviews was carried out. Members of 3 different types of families participated: homoparental, families with children who are the result of artificial insemination and families that adopted their children. Five categories emerged from the interviews: the meaning of family, acceptance, parenting, social life and attitudes to the family environment. The study finds that human give meaning to their families based on their experiences without differentiating gender, functions or roles. They demand equal rights for the conformation of the different family types and models, demonstrating the need to broaden perspectives on meanings attributed to family. Keywords: Family; diverse families; life experiences; parenting.
A Rapid Approach to Profiling Diverse Fungal Communities using the Minion™ Nanopore Sequencer

Field: Agricultural and Biological Sciences (Life Sciences)

The Oxford Nanopore Technologies MinION™ sequencer holds the capability to generate long amplicon reads; however, only a small amount of information is available regarding methodological approaches and the ability to identify a broad diversity of fungal taxa. To assess capabilities, three fungal mock communities were sequenced, each of which had varying ratios of 16 taxa. The data were processed through our selected pipeline. The MinION recovered all mock community members, when mixed at equal ratios. When a taxon was represented at a lower ratio, it was not recovered or decreased in relative abundance. Despite high error rates, highly accurate consensus sequences can be derived. This methodological approach identified all mock community taxa, demonstrating the MinION can be used as a practical alternative to profile fungal communities.
Editorial Incorporating

Field: Medicine (Health Sciences)

neutralizing antibody assays into routine clinical practice: a long and arduous road In this issue ofMultiple Sclerosis Journal, Farrell and co-workers1 describe a new luciferase-based, reporter-gene method for measuring neutralizing antibodies (NAbs) directed against interferon-beta (IFNb). In essence, this assay measures the IFN-induced luciferase activity in a fibrosarcoma cell line (HL-116), which has been stably transfected with a plasmid-containing a luciferase cDNA controlled by a DNA fragment containing the immedi-ate early IFN-stimulated gene (ISG) 6-16 promotor.2 Underscoring the complexity of the IFN system, the ISG 6-16 gene is part of an ISG family, members of which can either inhibit or enhance apoptosis by stabi-
A Systematic Review of Asynchronous Online Learning Opportunities for Paraeducators

Field: Social Sciences (Social Sciences)

Due to a variety of factors, many paraeducators receive little to no opportunities to advance their professional skills. Asynchronous online learning opportunities offer a flexible way for districts to provide paraeducators opportunities to advance their knowledge, although little is known about what online resources are available, their features, or their overall quality. A review was conducted of 19 freely available online learning opportunities to evaluate features, alignment with federal legislation and professional standards, active engagement features, and usability. Results indicated that features and quality indicators varied across resources and half of the resources required active user engagement. Limitations, suggestions for future development, and future research directions are discussed with an emphasis on factors related to online delivery.
Mental Diseases Peculiar to Certain Cultures: A Survey of Comparative Psychiatry

Field: Medicine (Health Sciences)

Modern psychiatry has developed in Western Europe, largely under French and German aegis, and latterly in the United States. It is pertinent to ask, since it deals with human behaviour in all its variety, if the concepts, working principles and empirically derived conclusions of psychiatry possess universal validity, wherever it might be practised. As one instance of the influence of cultural environment on psychiatric symptomatology (and also psychiatric practice), we may point to the “hysterogenic points “so often found in French hysterics by the Salpêtrière school of neurologists, who could provoke an hysterical attack or sometimes abort one by pressing on these points. Just across the Channel in England, among English hysterics, these phenomena could not be reproduced; they were, of course, special features of the disease, exhibited only in the atmosphere created by Charcot and his colleagues at that period. The psychiatrist in cultures farther removed from the civilization of Western Europe may well have reason to pause and ask if the principles and practice of orthodox psychiatry possess the same degree of truth or usefulness elsewhere than in Western Europe or America.
Heat shock proteins on beef quality

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract: The objective of this work was to quantify heat shock proteins (HSP) 27 and 70 in the Longissimus dorsi muscle of cattle during aging and to check their potential as biomarkers for meat quality. A total of 191 steers ½ South African Simmental x ½ Nellore (16-18 months, 391.7±99.7 kg), castrated, and feedlot finished were used. Meat quality was measured by pH, color, cooking loss, and shear force (SF) at 1 and 14 days of aging time. HSP27 and HSP70 were quantified according to the SF values in the more and less tender meat groups, with 20 samples each, for each aging time. HSP27 concentrations in more and less tender meat decrease from 1 to 14 days of aging, and do not differ when evaluated at the same period. HSP70 concentrations in more tender meat increase during aging, and, in less tender meat, there is no difference between periods or at the same period. The correlations between the HSP27 and HSP70 concentrations and meat quality characteristics are low for South African Simmental x Nellore, which indicate the low potential of HSP as biomarkers for these traits, especially for meat tenderness.
Real Marriages, Fake Marriages, and Marriages for Fun

Field: Arts and Humanities (Social Sciences)

Abstract This essay addresses the topic of “true marriage” by referring especially to a historiographical tradition that in Italy has examined the impact of the norms of the Council of Trent on the sacrament, measuring the effectiveness of their application in the early modern age. After a survey of the studies that, over the course of the 20th century, have observed the nuptial institution from the perspective of social, legal, and cultural history, a series of cases preserved in the Archives of the Dicastery for the Doctrine of the Faith are analyzed. These include a register dedicated to “matrimonia ficta” (fake marriages) involving a diverse set of situations, documented between the late sixteenth and the late eighteenth centuries, in which a wedding-like ritual was enacted, sometimes with both parties being aware of the fictitious nature of the ceremony but more often with one being kept in the dark, to achieve a union that appeared to be a marriage, at once bypassing and moving within the rules. Two cases from the fonds of the Inquisition of Siena complete the body of documents analyzed, paying particular attention to the meaning assigned “from below” to gestures (such as ring exchange or kissing) and to gender relations in the ritual performance.
Simulation of electrical characteristics and structural optimization for small-scaled dual-gate GeOI MOSFET with high-kgate dielectric

Field: Engineering (Physical Sciences)

The influences of the main structure and physical parameters of the dual-gate GeOI MOSFET on the device performance are investigated by using a TCAD 2D device simulator. A reasonable value range of germanium (Ge) channel thickness, doping concentration, gate oxide thickness and permittivity is determined by analyzing the on-state current, off-state current, short channel effect (SCE) and drain-induced barrier lowering (DIBL) effect of the GeOI MOSFET. When the channel thickness and its doping concentration are 10–18 nm and (5–9) × 1017 cm−3, and the equivalent oxide thickness and permittivity of the gate dielectric are 0.8–1 nm and 15–30, respectively, excellent device performances of the small-scaled GeOI MOSFET can be achieved: on-state current of larger than 1475 μA/μm, off-state current of smaller than 0.1 μA/μm, SCE-induced threshold-voltage drift of lower than 60 mV and DIBL-induced threshold-voltage drift of lower than 140 mV.
The Pavilion Book of Pavilions

Field: Arts and Humanities (Social Sciences)

Cricket pavilions can be large, medium or small, but their size is no real gauge of the pleasures that lurk within. They can be brick and concrete, lath and plaster, or in some cases even cardboard and corrugated iron. They are light and friendly, dingy and threatening, fully-equipped with a bar and historic photographs or barely sanitary with a splintery floor. They stand proudly at the edge of some of the most beautiful landscape in Britain, or hide guiltily beneath the glowering factory chimney of some Victorian industrialist's ambitions. A selection of 50 such pavilions is examined in this book. It is a personal selection which aims to reflect the national and local passion for the game of cricket.
Alcoholics Anonymous: Personal Stories, Relatedness, Attendance and Affiliation.

Field: Nursing (Health Sciences)

Alcohol misuse is a global health risk. Alcoholics Anonymous (AA) maintains a worldwide presence, with more than 2 million members and 110,000 groups in over 180 countries. Researchers and clinicians have become increasingly interested in mechanisms of action that contribute to positive outcomes in this “spiritual program of action,” but few have applied a theoretical framework to these efforts. In this three-paper dissertation, the nursing Theory of Human Relatedness (THR) was used to inform or direct qualitative, theoretical, and quantitative inquiries. \t\n\tFirst, a set of personal stories from the fourth edition of Alcoholics Anonymous was examined. Using methods derived from narrative analysis, a normative model was proposed. The overall storyline followed classical literary conventions for tragedy and comedy, incorporating regressive, progressive, and stable narratives. Prototypical stages (first or early drinking, alcoholic regression, hitting bottom, progress in the AA program, and stable sobriety) were embedded in a subjective, evaluative function over time. \n\tIn a second paper, THR was applied to alcoholism and recovery in AA. The organizing construct was relatedness, an individual’s level of involvement with persons, objects, environments, or spiritual entities, and the concurrent level of comfort associated with that involvement. Detailed analysis of an exemplar, and a survey of other personal stories, suggested that THR has the potential to serve as a unifying theory in the study of alcoholism and recovery in AA.\n\tFinally, a prospective, longitudinal study was conducted in Warsaw, Poland. Patients were assessed at baseline, one month, and 6-12 months for AA meeting attendance, affiliation, and alcohol consumption. Outcomes were obtained from 118 of 154 participants, 77% of the baseline sample. AA attendance alone did not predict improved drinking outcomes. In contrast, self-report of a spiritual awakening (one of the affiliation items) was significantly associated with abstinence, and the absence of any heavy drinking. Spiritual awakening was further associated with a number of other AA-related behaviors, collectively referred to as affiliation. Greater AA affiliation increased the likelihood of having had a spiritual awakening which, in turn, predicted improved drinking outcomes. Affiliation items were aligned with the core construct and concepts from the Theory of Human Relatedness.
Linker flexibility of IVS3-S4 loops modulates voltage-dependent activation of L-type Ca2+ channels

Field: Neuroscience (Life Sciences)

Extracellular S3-S4 linkers of domain IV (IVS3-S4) of L-type Ca2+ channels (CaV1) are subject to alternative splicing, resulting into distinct gating profiles serving for diverse physiological roles. However, it has remained elusive what would be the determining factor of IVS3-S4 effects on CaV1 channels. In this study, we systematically compared IVS3-S4 variants from CaV1.1-1.4, and discover that the flexibility of the linker plays a prominent role in gating characteristics. Chimeric analysis and mutagenesis demonstrated that changes in half activation voltage (V1/2) or activation time constant (τ) are positively correlated with the numbers of flexible glycine residues within the linker. Moreover, antibodies that reduce IVS3-S4 flexibility negatively shifted V1/2, emerging as a new category of CaV1 enhancers. In summary, our results suggest that the flexibility or rigidity of IVS3-S4 linker underlies its modulations on CaV1 activation (V1/2 and τ), paving the way to dissect the core mechanisms and to develop innovative perturbations pertaining to voltage-sensing S4 and its vicinities.
Simulating service reliability of a high frequency bus route using automatically collected data

Field: Decision Sciences (Social Sciences)

High frequency bus routes are subject to a variety of influences that can affect the quality of service provided to passengers. Since they have short headways and high passenger demand interaction between buses can easily develop, causing degradation in service reliability. This, in turn, can prompt service interventions to correct service reliability. Transit agencies are implementing new technology that provide rich data sets for analysis and are also experimenting with a variety of operating policies to improve service reliability. This research develops a simulation model of high frequency bus service in order to study the causes of service unreliability and strategies to alleviate it. The model is designed to be used in conjunction with data recorded by the Automatic Voice Annunciation System (AVAS), Automatic Passenger Counting (APC), and Automatic Fare Collection (AFC) systems and is calibrated to represent route 63, a key bus route in the Chicago Transit Authority (CTA) network The simulation model is first used to conduct a sensitivity analysis of the factors
Critical Beginnings: Selective Tuning of Solubility and Structural Accuracy of Newly Synthesized Proteins by the Hsp70 Chaperone System

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Proteins are particularly prone to aggregation immediately after release from the ribosome, and it is therefore important to elucidate the role of chaperones during these key steps of protein life. The Hsp70 and trigger factor (TF) chaperone systems interact with nascent proteins during biogenesis and immediately post-translationally. It is unclear, however, whether these chaperones can prevent formation of soluble and insoluble aggregates. Here, we address this question by monitoring the solubility and structural accuracy of globin proteins biosynthesized in an Escherichia coli cell-free system containing different concentrations of the bacterial Hsp70 and TF chaperones. We find that Hsp70 concentrations required to grant solubility to newly synthesized proteins are extremely sensitive to client-protein sequence. Importantly, Hsp70 concentrations yielding soluble client proteins are insufficient to prevent formation of soluble aggregates. In fact, for some aggregation-prone protein variants, avoidance of soluble-aggregate formation demands Hsp70 concentrations that exceed cellular levels in E. coli. In all, our data highlight the prominent role of soluble aggregates upon nascent-protein release from the ribosome and show the limitations of the Hsp70 chaperone system in the case of highly aggregation-prone proteins. These results demonstrate the need to devise better strategies to prevent soluble-aggregate formation upon release from the ribosome.