jimnoneill/paper-to-field-training huggingface dataset:
Application of artificial neural networks and genetic algorithms for crude fractional distillation process modeling

Field: Chemical Engineering (Physical Sciences)

This work presents the application of the artificial neural networks, trained and structurally optimized by genetic algorithms, for modeling of crude distillation process at PKN ORLEN S.A. refinery. Models for the main fractionator distillation column products were developed using historical data. Quality of the fractions were predicted based on several chosen process variables. The performance of the model was validated using test data. Neural networks used in companion with genetic algorithms proved that they can accurately predict fractions quality shifts, reproducing the results of the standard laboratory analysis. Simple knowledge extraction method from neural network model built was also performed. Genetic algorithms can be successfully utilized in efficient training of large neural networks and finding their optimal structures.
Espaço Público e Desenvolvimento:\na Encruzilhada da Cidadania

Field: Social Sciences (Social Sciences)

The paper intends to confront the developmentists approachs with the new challenges of \nan engaged citizenship, having as a ethical-politic reference the concern with the fragilization \nof the human condition, diminished in its dignity for the social implications and you set \nderived of a wild globalizated accumulation of the capital, in detriment of inclusive processes \nof development. Without pretense of finals conclusions, the paper look for to shimmer some \nalternatives for the construction of necessary public spaces for a deigns human existence, \ndrastically affected by the process, today hegemonic, of neoliberal globalization.
Chemical Reporter for Visualizing Metabolic Cross-Talk between Carbohydrate Metabolism and Protein Modification

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Metabolic chemical reporters have been largely used to study posttranslational modifications. Generally, it was assumed that these reporters entered one biosynthetic pathway, resulting in labeling of one type of modification. However, because they are metabolized by cells before their addition onto proteins, metabolic chemical reporters potentially provide a unique opportunity to read-out on both modifications of interest and cellular metabolism. We report here the development of a metabolic chemical reporter 1-deoxy-N-pentynyl glucosamine (1-deoxy-GlcNAlk). This small-molecule cannot be incorporated into glycans; however, treatment of mammalian cells results in labeling of a variety proteins and enables their visualization and identification. Competition of this labeling with sodium acetate and an acetyltransferase inhibitor suggests that 1-deoxy-GlcNAlk can enter the protein acetylation pathway. These results demonstrate that metabolic chemical reporters have the potential to isolate and potentially discover cross-talk between metabolic pathways in living cells.
[MUC16: The Novel Target for Tumor Therapy].

Field: Medicine (Health Sciences)

Mucin16 (MUC16), also known as carbohydrate antigen 125 (CA125), is a glycoprotein antigen that can be recognized by the monoclonal antibody OC125 detected from epithelial ovarian carcinoma antigen by Bast et al in 1981. CA125 is not present in normal ovarian tissue but is usually elevated in the serum of epithelial ovarian carcinoma patients. CA125 is the most commonly used serologic biomarker for the diagnosis and recurrence monitoring of epithelial ovarian carcinoma. MUC16 is highly expressed in varieties of tumors. MUC16 can interact with galectin-1/3, mesothelin, sialic acid-binding immunoglobulin-type lectins-9 (Siglec-9), and other ligands. MUC16 plays an important role in tumor genesis, proliferation, migration, invasion, and tumor immunity through various signaling pathways. Besides, therapies targeting MUC16 have some significant achievements. Related preclinical studies and clinical trials are in progress. MUC16 may be a potential novel target for tumor therapy. This article will review the mechanism of MUC16 in tumor genesis and progression, and focus on the research actuality of MUC16 in tumor therapy. This article also provides references for subsequent tumor therapy studies targeting MUC16. .
The Impact of Partners' Economic Incentives on Audit Quality in Big 4 Partnerships

Field: Business, Management and Accounting (Social Sciences)

ABSTRACT Economic incentives are fundamental for understanding auditor behavior. In this paper, we investigate the association between the extent of partners' fee-based compensation, partners' observable net wealth, and audit quality. Using a sample of Belgian Big 4 audit firms and their predominantly private clients, our results suggest a negative association between audit quality and partner fee-based compensation, and a positive association between audit quality and partner observable net wealth. Moreover, our results show that the latter association is most significant when a partner is carrying a lot of debt, which indicates that a partner's financial situation may affect audit quality. The extent of fee-based incentives also varies among partners of the same audit firm. Furthermore, partner and client characteristics differ based on the extent of fee-based compensation. Our findings should be of interest to regulators and audit firms, as they suggest that audit partners' economic incentives significantly affect audit quality. Data Availability: All data are publicly available from the sources identified in the text. JEL Classifications: M41; M42; D81.
Development of clinical genetics in Asia

Field: Medicine (Health Sciences)

Abstract This Special Issue on Clinical Genetics in Asia highlights a collection of articles showing the growth, development, and current status of clinical genetics in Asia. In this Introduction, the Guest Editors share on the themes of this issue to provide useful insights into the rapid growth of genomics and clinical genetics in this region. The contents of this Issue cover a range of topics from the history and development of clinical genetics in Asia to studies on disorders with clinical significance or phenotype differences in the Asian populations to the status of precision medicine. The goal is to provide a glimpse of how significantly the field of genetics in Asia has developed in recent years with the aspiration that this can serve as a catalyst to increase international collaboration and cooperation in combating genetic diseases. We hope that this issue shows Asia's readiness and willingness to be a part of more international conversations about genetics in future.
Sustained release of prednisone and mesalamine from diatom exoskeletons : bioinspiration for the development of safe oral drug delivery devices to tackle gastrointestinal diseases

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Mesoporous silicon and silica-based particles have recently been synthesized and proposed for \nthe controlled delivery of several drugs [1,2]. On the other hand, nature and in particular marine \norganisms have been the source and inspiration for the development of different biomedical \napplications, including drug delivery devices [3]. On the border of both rests diatoms \nexoskeletons, nature-made porous silica-based microparticles with amazing morphological \nfeatures, promising a high potential in drug delivery. Nevertheless, its safety and drug \npermeability on oral formulations have not yet been studied. In this study, we have demonstrated \nthat diatoms silica microparticles (DSM) have almost no toxicity in colon cancer cells Caco-2, HT- \n29, HCT-116 and Caco-2/HT-29, even at concentrations as high as 1000 μg/mL. Moreover, the \ndelivery profile of two common drugs to address gastrointestinal diseases, mesalamine (antiinflammatory) \nand prednisone (glucocorticosteroid). DSMs are able to release prednisone in a \ncontrolled manner and change its absorption pattern, which may improve the safety of its \nadministration. In addition, DSMs can enhance the permeation of mesalamine. These results \nconfirm the potential of DSMs for the development of oral formulations for the therapy of \ngastrointestinal diseases.
Synthesis of Ring-Fluorinated Thiophene Derivatives\nBased on Single C–F Bond Activation of CF<sub>3</sub>-Cyclopropanes: Sulfanylation and 5-<i>endo</i>-<i>trig</i> Cyclization

Field: Chemistry (Physical Sciences)

The treatment of\nCF<sub>3</sub>-bearing cyclopropanes with Et<sub>2</sub>AlCl generated\nstabilized difluorocarbocations, which underwent a nucleophilic addition\nof thiocarboxylic acids or thiols. The sulfur functionality was introduced\nat the position δ to the fluorine substituents in a regioselective\nmanner (single activation of CF<sub>3</sub>-cyclopropanes). The formed\n1,1-difluoro-1-alkenes underwent successive deesterification/5-<i>endo</i>-<i>trig</i> cyclization. Intramolecular vinylic\nsubstitution proceeded in an aprotic solvent, whereas intramolecular\naddition proceeded in a protic solvent to afford pharmaceutically\nand agrochemically promising 2-fluoro-4,5-dihydrothiophene and 2,2-difluorotetrahydrothiophene\nscaffolds, respectively.
A Lost Horizon: Perils and Possibilities of the Obvious

Field: Arts and Humanities (Social Sciences)

Research Article| July 01 2010 A Lost Horizon: Perils and Possibilities of the Obvious JOHN J. McDERMOTT JOHN J. McDERMOTT Texas A&M University Search for other works by this author on: This Site Google The Pluralist (2010) 5 (2): 1–17. https://doi.org/10.5406/pluralist.5.2.0001 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation JOHN J. McDERMOTT; A Lost Horizon: Perils and Possibilities of the Obvious. The Pluralist 1 January 2010; 5 (2): 1–17. doi: https://doi.org/10.5406/pluralist.5.2.0001 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveUniversity of Illinois PressThe Pluralist Search Advanced Search The text of this article is only available as a PDF. Copyright 2010 Board of Trustees of the University of Illinois2010 Article PDF first page preview Close Modal You do not currently have access to this content.
Implementing Data to Care—What Are the Costs for the Health Department?

Field: Health Professions (Health Sciences)

Background: The Cooperative Re-Engagement Controlled Trial (CoRECT) is a randomized controlled trial that uses a combined health department-provider data to care (D2C) model to identify out-of-care HIV-infected persons. We present cost data for programmatic aspects of the trial during the start-up period (first 30 days of the study). Methods: We used microcosting methods to estimate health department start-up costs. We collected start-up cost data between September 2016 and December 2016; 3 health departments completed a form to capture expenses for the initial 30 days of study implementation; the start date varied by health department. All costs are expressed in 2016 US dollars. Results: Among the 3 health departments, the total start-up costs ranged from $14,145 to $26,058. Total start-up labor hours ranged from 224 to 640 hours. Conclusions: As D2C expands nationally with cooperative agreement, PS 18-1802 health departments may be able to use a similar analysis to consider the labor, time, and resources needed to implement D2C within their jurisdiction.
Moderating Role of Financial Characteristics in Sectoral Performance During the Period of Economic Disruption: Evidence from the Covid-19 Pandemic

Field: Economics, Econometrics and Finance (Social Sciences)

The exogenous shock of the COVID-19 pandemic disrupted the equity market worldwide; however, the extent of its impact on the sectoral returns varied. Sectors like aviation, hospitality, and retail were badly affected as a result of the imposed lockdowns. Contrarily, the technology, e-commerce, pharmaceutical, and biotech sectors thrived for the same reasons. The present study evaluates the impact of the disruption of COVID-19 on firms from diverse sectors and examines the moderating effect of firms’ financial characteristics on sectoral performance. The study establishes a causal relationship between the firm’s cumulative abnormal returns generated during the various phases of the pandemic and their sectoral and financial characteristics using data for 317 firms listed on the National Stock Exchange of India. The results indicate that financial characteristics such as cash holdings, dividends, asset tangibility, and analyst coverage moderate the impact of the COVID-19 pandemic on sectoral performance. Findings provide evidence in support of the role of information asymmetry during economic disruptions.
EDUCATIONAL AND PSYCHOLOGICAL ASPECTS OF DEVELOPING OF ECOLOGICAL IDENTITY

Field: Psychology (Social Sciences)

In the modern world one of the most present problems is the state of living environment and its protection and preservation. In this context, forming of ecological identity is highly important in the aim of creating the basis for pro-ecological behaviors which could allow to present and future generations quality survival on the Earth. Ecological identity is related to the relation of human beeing to the nature, his/her connection with the nature as to cognitive, affective and behavioral elements by which we are acquiring knoledge about nature, developing emotional relation to it which is manifested in behavioral segment. Development of stronger or weaker ecological identity determines our motivation for pro-ecological behaviors. We can find the basis of ecological identity in two basic orientation to the nature, anthropocentric and eco-centric orientations where both of them include high evaluation of the importance of the nature for human kind but where anthropocentric orientation puts emphasis on human being and the need for preservation of nature for human wellbeing and improving of the quality of human life while eco-centric orientation puts emphasis on intrinsic value of the nature that should be preserved for its own. Development of ecological identity begins in the early childhood and educational process and the process of socialization take part in it and that is the way in which pro-ecological norms and values, later attitudes are instilling in the child. As facts of a high importance, in literature it is stressed staying and activities in nature where children make direct connection with the bounties of nature gradually realizing its values and developing habits which will contribute to its preservation. Such influences begin in the family but, it is very important that preschool institutions and early grades of primary school have developed programs of ecological education and adequate methods for its implementation. Development of ecological identity is continuing further through later scooloing and through organizational ecological identity which should be the part of organizational culture. The aim of this work is elucidation of meaning of ecological identity, about which there has not been many discussions in our country, analysis of the factors which are participating in its development and of the role of educational process in forming and further development of ecological identity as the foundation of the pro-ecological behavior.
Motivations for Social Interaction: The Case of Pokémon Go After the Fad Ended

Field: Psychology (Social Sciences)

Objective We survey Pokémon Go players regarding motivations/patterns of gameplay and sociability over time to understand human interaction in augmented game settings. We disentangle effects of solo versus social and past versus current gameplay through replication of the Pokémon Go Motive Scale. Methods We use OLS regression to determine how motivation affects hours of gameplay, to measure changes in hours spent playing Pokémon Go, and to capture perceptions of engagement with the game over time. Results We find seven motivations: exercise, fun, escapism, nostalgia, friendship maintenance, relationship initiation, and achievement. Initiating new relationships leads to increased social playing time and increased perceptions of Pokémon Go as both interesting and challenging. Conclusion Intrinsic rewards hold the most staying power as a distinct motivation for gameplay. Implications go beyond Pokemon Go gaming to shed light on the differential impact of human motivation for social interaction in games that utilize augmented reality.
Association of High Glomerular Filtration Rate with Arterial Stiffness in Adults: A Propensity Score Analysis. Mark Study

Field: Medicine (Health Sciences)

There is evidence that the reduction in estimated glomerular filtration rate (eGFR) increases the risk of arterial stiffness and cardiovascular disease (CVD) [1,2], and that CVD is the major cause of morbidity and mortality in subjects with decreased eGFR [3,4].
From Cheesecake to Chief: Newspaper Editors' Slow Acceptance of Women

Field: Social Sciences (Social Sciences)

Abstract The struggle of women journalists to achieve equality in the newsroom begs the question of whether editors were reflecting social mores or practicing a more virulent form of male supremacy. The latter explanation is supported by a study of 680 editions of the newsletter of the American Society of Newspaper Editors, the Bulletin, from its inception in 1925 through the 1988 tenure of ASNE's first female president. Until the second wave of the women s rights movement took hold, editors saw women as sexual objects and housewives whose fragile and emotional natures left them congenitally unsuited for newsroom roles beyond the women's section. The unfiltered words of the editors betray a systemic gender bias that explains why newsroom discrimination was more entrenched than in society as a whole.
The co-ordination of small molecules by manganese(II) phosphine complexes. Part 11. The co-ordination of dioxygen by manganese(II) complexes containing long-chain phosphine ligands

Field: Chemistry (Physical Sciences)

Manganese(II) complexes of long-chain phosphines, [MnX2(phosphine)][X = Cl, Br, or I; phosphine = P(C12H25)3, P(C14H29)3, P(C16H33)3, PPh(C12H25)2, PPh(C14H29)2, or PPh(C16H33)2], have been prepared. They form highly coloured 1 : 1 adducts with dioxygen, [MnX2(phosphine)(O2)], in both toluene and tetrahydrofuran (thf) solution. Infrared and e.s.r. spectra strongly suggest that these [MnX2(phosphine)] complexes are pseudotetrahedral dimers in the solid state and in toluene, contrasting vividly with the previously reported structure of [Mnl2(PPhMe2)]. Some molecular weight data indicate the product of dioxygenation in toluene to be the monomeric [MnX2(phosphine)(O2)] species. Dioxygen-binding curves for toluene and thf solutions have been obtained and equilibrium constants, KO1, for the dioxygenation reaction have been deduced. The general observation that KO2 increases and P50, the partial pressure when 50% of sites are deoxygenated, decreases for changes in halide ligand from Cl to Br to I in both solvents mirrors earlier observations with complexes of short-chain phosphines. The affinity of the complexes for O2 in thf is in the order phenyldialkylphosphines < trialkylphosphines. Hill coefficients, n, are approximately 1 for thf solutions of the chloride and bromide complexes, but for the iodides in thf and all of the complexes in toluene n lies in the range 1.10–1.64 indicating co-operativity for O2 binding, which may be related to the dimeric structure proposed for the complexes in toluene.
Peri-Urbanization of the Property Market and Craft Villages

Field: Social Sciences (Social Sciences)

Since the 1990s, Hanoi has embarked upon a process of '˜urban catch-up' enabling the city to attain the status of an attractive international metropolis and also to control a territory in keeping with its urban ambitions. Its extension is accelerating over densely populated spaces, and in particular over an area where more than 500 villages have specialized in craft activities. Against a background of soaring land prices, we will consider the ability of inhabitants of these densely populated craft villages to gain access to land and develop their activities, which are necessary conditions for inducing them to stay put, avoiding an exodus towards the city centre.
Transcriptome Profiling Analysis of Muscle Tissue Reveals Potential Candidate Genes Affecting Water Holding Capacity in Chinese Simmental Beef Cattle

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Water holding capacity (WHC) is an important sensory attribute that greatly influences meat quality. However, the molecular mechanism that regulates the beef WHC remains to be elucidated. In this study, the longissimus dorsi (LD) muscles of 49 Chinese Simmental beef cattle were subjected to RNA sequencing (RNA-seq), among which eight individuals with the highest WHC (H-WHC) and the lowest WHC (L-WHC) were selected for transcriptome analysis. A total of 1256 genes were identified as differentially expressed genes (DEGs) between two groups, of which 948 genes were up-regulated and 308 genes were down-regulated. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment revealed that DEGs were significantly enriched in 24 GO terms and 78 pathways. Additionally, based on protein-protein interaction (PPI) network, animal QTL database (QTLdb), and relevant literature, the study not only confirmed seven genes ( HSPA12A, HSPA13, PPARg, MYH10, MYL2, MYPN , and TPI1 ) influenced WHC in accordance with previous studies, but also identified six genes ( ITGAV, FGF2, THBS1, DCN, COL4A1 , and TGFBR1 ) as the most promising novel candidate genes affecting the WHC. These findings could offer important insight for exploring the molecular mechanism underlying the WHC trait and facilitate the improvement of beef quality.
Horses, gender, and (queer) masculine desire, or how experimental found footage film recycles three Hollywood films

Field: Arts and Humanities (Social Sciences)

Abstract Although the experimental found footage film recycles Hollywood films so that the outcome may radically differ from the original story, there are no accounts on how it adapts images from mainstream cinema to represent human–animal relations, linking to gender and masculinity. To fill this gap, I discuss how experimental film Horsey recycles footage from three Hollywood productions—Reflections in a Golden Eye, The Swimmer, and The Black Stallion—to construct a new narrative, which displays a very close conformity to the prior text, shifting the focus to human–horse interactions. Raising questions about the traditional understanding, scope, and limits of adaptation in avant-garde film studies, Horsey fits in with the broader tradition of cinematic recycling of mainstream cinema as it exemplifies intertextuality as a direct form of quotation, taking quotation as appropriation through cuts, detournement, compilation and free association. Particularly, following Guy Barefoot’s understanding of adaptation as an intertextual form of recycling, Horsey is distinctive in its sole use of found footage from the three Hollywood films as it fully acknowledges the recycled material, strongly alluding to the original stories, and simultaneously re-processes them through a collage of pre-used footage, slow motion, washed-out colours, and an altered soundtrack. Despite appearing to merely extract images and sounds from Reflections, The Swimmer, and The Black Stallion, Horsey emerges as a productive site for recycling Hollywood cinema, placing it into new contexts and audio-visual configurations and offering more complex, engaging ways of looking at how humans connect to horses.