jimnoneill/paper-to-field-training huggingface dataset:
Reduced-Intensity Conditioning Followed by Allogeneic Stem Cell Transplantation (allo-SCT) Is an Effective Salvage Treatment for Peripheral T-Cell Non-Hodgkin’s Lymphoma (PTCL).

Field: Medicine (Health Sciences)

Abstract Patients with relapsed PTCL have a poor prognosis. We had previously shown the existence of a graft-versus-lymphoma effect against PTCL (J Clin Oncol, 2004). In the present report, we extended our previous observations to 26 patients (pts) receving allo-SCT. All patients received several courses of debulkying chemotherapy (usually 3 DHAP and/or high-dose chemotherapy) followed by the same RIC regimen containing thiotepa (10 mg/kg), fludarabine (60 mg/ms) and cyclophosphamide (60 mg/kg). GVHD prophylaxis consisted of cyclosporine A and short-course methotrexate. Patients’ median age was 45 years (range, 15–64). Histologic PTCL subtypes included: PTCL not otherwise specified (n=12), ALCL (n=7), angioimmunoblastic (n=3), others subtypes (n=4). Twenty-two pts (84%) received transplant from HLA-identical sibling, 3 from haploidentical sibling and one from unrelated donor. The median time from diagnosis to transplantation was 17 months. Thirteen patients (50%) had failed a previous auto and the majority received at least 2 lines of chemotherapy before allo-SCT. Seven (27%) and 13 pts (50%) were in CR and PR at the time of allo-SCT, respectively. At median follow-up of 27 months (range, 8–73), 17 (65%) were alive (n=14 in CR) and 9 died (n=6 disease, n=3 toxicity). The estimated 3-year TRM was 13%. The estimated 5 year OS and PFS projections were 61% (95% CI, 41–81%) and 51% (95% CI, 30–72%), respectively. Relapses occurred in the first 6 months after allo-SCT and we did not observe differences in PFS between specified and unspecified variants. De-novo acute GVHD (II/IV) and chronic GVHD incidence were 28% and 24%, respectively. Eight patients received DLI, 6 for relapse, 1 pre-emptive, 1 for infection: 3 responded (n=1 CR, n=2 PR). Following DLIs, 4 patients developed GVHD with associated a clinical response. In conclusion, our data indicate: 1) long-term disease control was achieved in patients with an aggressive subtype of NHL; 2) although optimal therapeutic strategies for relapsed PTCL are yet to be defined, further prospective evaluation of allo-SCT is required.
On the Correlation of Primary Root Length, Meristem Size and Protoxylem Tracheary Element Position in Pea Seedlings

Field: Agricultural and Biological Sciences (Life Sciences)

Pea seedlings (Pisum sativum L. cv. Alaska) were darkgrown in vermiculite. Roots of various lengths were cleared, stained and measured to determine the relative meristem height (MH), width and volume and the distance to the most proximal protoxylem tracheary element (PTE). A correlation was found between root length, MH and PTE position as follows: in roots from 4–40 mm as the root elongated the MH lengthened and PTE position increased its distance from the body/cap juncture; in roots 40–80 mm MH and PTE position remained approximately constant; in longer roots (80–120 mm) MH became shorter, and PTE position closer to the tip as the root elongated. The relationship, using our measurement procedure was that for every 0.19 mm change in MH, the PTE position changed by 1 mm. This response was partially growth rate dependent since short roots (4–80 mm) grew at a constant rate and longer roots (80–140 mm) grew slower. Root manipulations and trifluralin treatment, to inhibit cell division, caused tip swelling and modulated the position of the PTE toward the root tip. The control of the spatial relationship between meristem size and maturation position is discussed.
The formulation of state equations for linear electric circuits with perfect magnetic couplings: the case of nondegenerate circuits

Field: Engineering (Physical Sciences)

In this paper, we have described a systematic method for the formulation of the state equations of linear circuits without topological degenerations, which contain perfect magnetic couplings, which are couplings with zero determinant of the inductance matrix. In these circuits, 'hidden' relationships appear between the capacitor voltages and inductor currents. According to the proposed procedure, all capacitors and inductors of the circuit are replaced by independent and dependent sources, creating in this way a resistive circuit. Afterwards, the state equations are written by solving the circuit using one of the known methods of the electrical circuits.
Signal processing based damage detection in structures subjected to random excitations

Field: Engineering (Physical Sciences)

Damage detection methodologies based on the direct examination of the nonlinear-nonstationary characteristics of the structure dynamic response may play an important role in online structural health monitoring applications. Different signal processing based damage detection methodologies have been proposed based on the uncovering of spikes in the high frequency component of the structural response obtained via Discrete Wavelet transforms, Hilbert-Huang transforms or high pass filtering. The performance of these approaches in systems subjected to different types of excitation is evaluated in this paper. It is found that in the case of random excitations, like earthquake accelerations, the effectiveness of such methodologies is limited. An alternative damage detection approach using the Continuous Wavelet Transform (CWT) is also evaluated to overcome this limitation. Using the CWT has the advantage that the central frequencies at which it operates can be defined by the user while the frequency bands of the detail functions obtained via DWT are predetermined by the sampling period of the signal.
PHYSICAL FITNESS ATTRIBUTES, VITAMIN D, DEPRESSION, AND BMD IN OMANI’S CHILDREN

Field: Medicine (Health Sciences)

Physical fitness attributes, vitamin D, depression, and BMD in Omani’s Children 9-12 years old were investigated in 54 girls and 42 boys (average age of 12.9 ± 1.6) to assess health related fitness, body composition. Eighty two percent of the females and forty two percent of the males were deficient in vitamin D ( 0.05) in females between those with normal and those with low vitamin D levels. These results were also replicated in males except for grip and cardio-respiratory components. Initial analysis also indicates that the prevalence of symptoms of depression among Omani children was 32% ranging from mild to severe depression with negative correlation with vitamin D deficiency is significant at the 0.01 level (-0.353 2-tailed). The females are deficient in vitamin D, might be susceptible to the early diagnosis of osteoporosis and depression due to their deficiency. Children should be involved in physical activity program and meet the required sunlight exposure during all season to gain a healthy lifestyle.
Transparency materialised: how registers can regulate access to documents?

Field: Social Sciences (Social Sciences)

Abstract Proactive transparency in the form of electronic provision of documents is required by law in the EU. It has long been acknowledged in law and technology studies that digital technology can have legal consequences when implemented to perform a legal function. Consequently, the technological design of document registers has the ability to limit as well as enhance access to documents. When technology can have such regulatory powers, incorporating it into a legal function requires closer attention as to how or why it is so. This article will provide a close analysis of the European Commission’s main Register of Documents (RegDoc) to study the implications of technological design for access to documents. Transparency is approached through a procedural view, highlighting its mechanisms. The article uses a HCI based walkthrough method for the case-study artefact critique of the RegDoc. The main findings suggest that there are two specific affordances of the RegDoc that limit access, especially for users who do not have pre-existing knowledge of the documents they are searching for. These affordances are, first, the scope of the dataset and, second, searchability. Overall, designing technology for legally relevant functions should take into account the wider legal framework that the technology aims to cater for. Attention should be paid to the affordances that can make a legal difference in a technology created to perform a legally relevant task.
Clusters Initiatives in Port Hinterlands

Field: Business, Management and Accounting (Social Sciences)

For the effective use of port hinterlands, the concept of supply chain logistics should be applied. Port hinterlands have a geographical advantage and an important infrastructure nearby. However, these merits of port hinterlands are not very significant from the point of view of supply chain logistics. In this respect, clustering can emerge as an alternative to develop port hinterlands. Small and medium enterprises (SMEs) that are related with specialized industries in relevant regions can be clustered into a port hinterland to improve the competitiveness of supply chain logistics. In addition to the synergy effect it creates, clustering is expected to meet the construction objectives of port hinterlands thanks to its export-oriented nature. Types of businesses that would create synergy effects through clustering should be selected among regionally specialized industries adjacent to a port hinterland. The characteristics of selected businesses among candidates should also accord with the successful factors of clustering, technology accumulation, the likelihood to secure skilled labor, innovation and R&D capacities. As an illustration, locating a packaging cluster near a port can lead to a better connection between manufacturing to logistics. The “total logistics service with packaging” is not a new concept, but this could be a more cost efficient business model in port hinterlands.
310. The Impact of Microscan versus Vitek-2 for Automated Susceptibility Testing on the Utilization of Vancomycin Alternatives for the Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia

Field: Medicine (Health Sciences)

Abstract Background Automated susceptibility testing (AST) provides minimum inhibitory concentrations (MIC) to guide effective antibiotic therapy. AST is critical for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, as susceptible MIC values ≥ 1.5 µg/mL are associated with vancomycin (VAN) failure. The Microscan (MS) instrument may report elevated MIC values compared to Vitek-2 (VTK), thus impacting treatment. This study aimed to evaluate the impact of MS versus VTK on VAN alternative use in the treatment of MRSA bacteremia in a Texas health system. Methods This was a retrospective cohort study of patients admitted to the Ascension Seton health system in Austin, TX. Patient eligibility included: age ≥18 years, ≥1 positive MRSA blood culture, ≥72 hours of MRSA therapy, and VAN use within 48 hours of positive culture. Patients were stratified into the MS group (May 2013-Dec 2016) and VTK group (Jun 2017-Mar 2020). The primary outcome was therapy switch from VAN to VAN alternatives. Secondary endpoints include S. aureus MIC, 30-day all-cause mortality, 30 and 90-day readmission, and length of hospital stay (LOS). Outcomes were compared between groups using appropriate bivariable comparisons, as well as multivariable logistic regression and propensity score-adjusted logistic regression. Results A total of 199 patients were included: 91 in the MS group and 108 in the VTK group. Switch to VAN alternative was 56% vs. 19% (p&lt; 0.0001) for MS and VTK, respectively. The median (interquartile range) MIC value reported was 2 μg/mL (2 – 2) and 1 μg/mL (0.5 – 1) for MS and VTK, respectively (p&lt; 0.0001). Thirty-day readmission (19% vs. 20%, p=0.7647) and 30-day mortality (10% vs. 9%, p=0.5262) were comparable between MS and VTK groups, respectively. Hospital LOS significantly decreased in the VTK period (16 days vs. 12 days, p=0.0153). The MS group was the only independent positive predictor of VAN alternative therapy: logistic regression, OR 5.64 (95% CI 1.67–18.99) and propensity score adjusted, OR 4.21 (95% CI 1.32–13.48). Conclusion Since implementation of VTK from MS, Ascension Seton hospitals experienced a decreased median VAN MIC for MRSA bacteremia as well as therapy switches from VAN to VAN alternatives without affecting other patient health outcomes. Disclosures All Authors: No reported disclosures
Republic of Madagascar: Financial System Stability Assessment, including Reports on the Observance of Standards and Codes on the following topics: Banking Supervision, and Anti-Money Laundering

Field: Economics, Econometrics and Finance (Social Sciences)

The insurance sector is underdeveloped and has been inadequately supervised to date, as the regulator lacks the requisite independence, skills, and resources. The three public pension systems, which cover less than 10 percent of the active population, appear to be fiscally unsustainable. The banking regulatory and supervisory framework is broadly adequate, although implementation and enforcement need further strengthening. The weak financial position of the Central Bank of Madagascar (BCM) could undermine macroeconomic and financial policies and contribute to economic and financial instability.
The Circular Economy of the Islamic Group Lending Model: Lending Money for Garbage in Return

Field: Business, Management and Accounting (Social Sciences)

The Model of Group Lending has been flourishing in the Microfinance Industry. This model has been used widely in the world to serve the needy and un-bankable group of people by lending money plus interest addition. In Islamic finance also embrace this model by omitting the interest and applying the Qardul Hassan to finance the members so that they can fulfill their daily need. The problem of this divine scheme is the sustainability of the microfinance since they have a burden to bare the operational cost due to the non – interest feature of the financing. This paper tries to solve this problem by utilizing the household garbage as the media to repay the Qardul Hassan financing to the Islamic Microfinance Institution (IMFI) so that it can be processed by the IMFI to create more added value product, selling it to get more income and achieving the organization sustainability.
Siratur gold deposit in the black shales of the ophiolite association (the Southern Urals)

Field: Earth and Planetary Sciences (Physical Sciences)

The Siratur gold deposit is located in the northern part of the South Ural segment of the Main Ural Fault. Its ore zone is confined to the area of the tectonic junction of the serpentinite of the Nurali massif and the submeridional strip of carbonaceous schists of the Ordovician Polyakovka Formation. Its composition is widely represented basalts with chemical characteristics of the main effusive rocks of the mid-ocean ridges. In the black shale deposits of the Siratur deposit, gold ore mineralization is mainly represented by the gold-sulfide vein-disseminated type, and in the listwanite-beresite complex, gold-quartz-low-sulfide vein-streaked type. Microprobe studies of zolotins showed that gold in ores of the first type has a low-qality of 670–820, and in the second — 940–970. The deposit can be attributed to the polygenic and polychronous type.
Skin Segmentation Based on Double-Models

Field: Computer Science (Physical Sciences)

In the process of skin tracking of video, Skin color model often can't get expect affection in some environment. This paper brings out double-models based on analysis of color space and traditional skin color models. Using the interaction of two models, We can adjust their parameters which can adapt to the environment. The skin color modeling include two steps. First it is stat stylebooks' parameters. and Second is dynamic parameters' adjustment. This paper chooses ellipse clustering model and SGM as basic models and YCbCr color space to describe the pixels. We use the minimum outer rectangle to get ellipse clustering model's static parameters, and use the Fisher threshold rules to compute the SGM's chromaticity diagram. When adjust the dynamic parameters, we look on the result of these two models recognition based on static parameters as some stylebooks. From the result of experiment, double-models have the advantages of strong robust and can boost the segmentation efficiency.
TINJAUAN YURIDIS TERHADAP VISUM ET REPERTUM SEBAGAI ALAT BUKTI DALAM PEMERIKSAAN

Field: Social Sciences (Social Sciences)

Visum et repertum is an equipment of valid evidence in court session and confessed in code/law and has permanent legal force, based on rule of section 186 KUHAP. The purpose of this paper is to explain and to give more detail about the visum et repertum which can be made as a means of valid evidence to determine death causes. The method used is bibliography study. The result shows that not only the visum et repertum as a means of evidence, but also the verification in the court will be believed by the confidence of judge for knowing that crime already happened as an effort in looking for the fact.
Sulfur in nature and its impact on spiders

Field: Agricultural and Biological Sciences (Life Sciences)

This article provides information on the sulfur-containing LSD (decoction of sulfuric lime) and externally active substance (EAS) used against cotton spider mites. It has been established that when using these preparations, the Bukhara-6 variety received an additional yield of 4.2-4.4 c/ha with good commercial indicators.
Extreme value modelling of the South African Industrial Index (J520) returns using the generalised extreme value distribution

Field: Economics, Econometrics and Finance (Social Sciences)

The aim of this study is to analyse the behaviour of extreme returns of the South African Industrial Index (J520) (years 1995-2018) and estimate extreme risk measures using the Generalised Extreme Value Distribution (GEVD). The results reveal that for the 8, 20 and 40 quarterly return periods, the estimated extreme losses are 9.28%, 13.65% and 17.03%, respectively. The extreme possible gains for the same periods are 9.81%, 11.63% and 12.68%, respectively. Therefore, in the short term (8 quarters) the extreme losses are less than the extreme gains, but in the medium to long term (20 and 40 quarterly return periods), the extreme losses are greater than the extreme gains. This study uses the GEVD to build models that can be used to estimate extreme risk measures that can act as effective decision-making tools for minimising risk exposure and maximising on the potential gains in equity portfolio risk management. Highlights: (1) In the short term the gains in the South African Industrial Index are greater than the losses. (2) However, in the medium to long term, for an investor invested in the same Index, the losses are greater than the gains.
A temperature compensated overcurrent and short-circuit detection method for SiC MOSFET modules

Field: Engineering (Physical Sciences)

This paper presents an overcurrent and short-circuit (SC) detection method for high current SiC MOSFET modules. It adapts the existing desaturation detection (= U CE , de s at method) known from IGBTs. These adjustments include separate detection paths for hard switching faults (HSF) and fault under load (FUL) as well as overcurrent. The necessity of a junction temperature compensation for detecting each type of fault (HSF, FUL or overcurrent = OC) is discussed.
Integrating Distributed Services

Field: Computer Science (Physical Sciences)

Modular applications, components, and services are all ways of describing the product of an organization’s efforts to embody its capabilities in autonomous software modules. In fact, the integration of services using well-established workflow paradigms could amplify an organization’s capabilities with the cre ation of a full-blown, inter-organizational system of systems. This is the essence of Web-scale workflows. Considering the recent popularity and acceptance of service-oriented technologies, the application of such distributed systems is only limited by imagination, but it’s also important to understand existing research challenges and their implications to various Web-scale workflow domains.
Evaluating the cytotoxicity of tin dioxide nanofibers

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Tin dioxide nanofibers (SnDNFs) are small fibers that have many applications. Tin dioxide nanofibers can be used in cosmetics, solar cells, toxic gas release sensors, and air pollution control. To date there have been few studies on the cytotoxicity of SnDNFs. The goal of this research is to determine if electrospun SnDNFs are toxic in a lung cancer cell line (A549). Considering the nano-scale size of the fibers, they can easily be inhaled and enter the pulmonary system and cause toxic effects in the lung. Occupational exposure to SnDNFs has been linked to pulmonary disease, making the A549 cell line important in this study. Nanofiber toxicity can vary based upon the characteristics of the fibers. Smaller nanofibers have been shown to have more toxic effects than their larger counterparts. The synthesized SnDNFs were characterized using SEM, Raman spectroscopy, and powder X-ray diffractometer (PXRD). SEM images showed the fibers to be 200-300 nm in diameter. Raman spectroscopy and PXRD indicated that the fibers were in the rutile phase. After quantifying the SnDNFs, the fibers were introduced to A549 cells at concentrations ranging from 0.02-500 µg mL-1 and incubated at 37°C. These cells were quantified with the MTT assay to measure cell proliferation (IC50 = 0.02 mg mL-1), while lactate dehydrogenase (LDH) leakage was used to determine cytotoxicity, and apoptosis assays to assess the mechanism of cell death. Increasing concentration of SnDNF generated a consequential decrease in cell proliferation and viability. The percent cytotoxicity of SnDNF was not significantly changed at the various concentrations and time frames. In order to gain additional insight about the mechanism of cytotoxicity of SnDNFs, genes with links to inflammation and apoptosis were evaluated and found to be over-expressed in treated cells. At the concentrations of SnDNF examined, SnDNF was mildly toxic to the A549 cells.
Controlling the Sex of Flowers in Different Stages of Growth and Development of Melon (Cucumis melo var. reticualus L.) with Ethephon Application

Field: Agricultural and Biological Sciences (Life Sciences)

To investigate the effect of ethephon on control of male flowers in melon, a split plot experiment, with randomized complete blocks design and three replications, was conducted in Agricultural and Natural Resources Research Center of Varamin, Iran, during 2005-2006. The main factor included three levels of plant growth stage (3-leaf, 6-leaf and early reproductive stage) and sub-plots included four ethephon levels (0, 100, 200 and 300 mg/L). The appearance time of female flowers, number of male and female flowers (7 and 14 days after application of ethephon), total yield and female/male flowers ratio were evaluated. Results showed that plant response to increasing concentration of ethephon depends on plant growth stage. By using the ethephon concentrations of 100, 200 and 300 mg/L, the emergence of female flowers was delayed 6, 13 and 15 days, respectively, in comparison to control. The highest yield (26430 kg/ha) was obtained with spraying of 200 mg/L ethephon in trifoliate plants. In this case, the ratio of female to male flowers was highest (81.5%). A high dose of ethephon (over 200 mg/L) was associated with reduced yield and ratio of female to male flowers, at all stages of plant growth, especially in reproductive growth stage. The results this research showed that the beneficial effects of ethephon application is possible only if the right time is chosen with respect to plant growth.