jimnoneill/paper-to-field-training huggingface dataset:
CD303 (BDCA-2) – a potential novel target for therapy in hematologic malignancies

Field: Medicine (Health Sciences)

Plasmacytoid dendritic cells (pDCs) serve as immunoregulatory antigen-presenting cells that play a role in various inflammatory, viral, and malignant conditions. Malignant proliferation of pDCs is implicated in the pathogenesis of certain hematologic cancers, specifically blastic plasmacytoid dendritic cell neoplasm (BPDCN) and acute myelogenous leukemia with clonal expansion of pDC (pDC-AML). In recent years, BPDCN and pDC-AML have been successfully treated with targeted therapy of pDC-specific surface marker, CD123. However, relapsed and refractory BPDCN remains an elusive cancer, with limited therapeutic options. CD303 is another specific surface marker of human pDCs, centrally involved in antigen presentation and immune tolerance. Monoclonal antibodies directed against CD303 have been studied in preclinical models and have achieved disease control in patients with cutaneous lupus erythematosus. We performed a comprehensive review of benign and malignant disorders in which CD303 have been studied, as there may be a potential future CD303-directed therapy for many of these conditions.
Measured and Computed Resistance Values for Vertical Ground Rods

Field: Engineering (Physical Sciences)

This paper aims to identify the causes behind the discrepancy between measured and computed steady-state ground resistance (RDC) in grounding systems comprised of vertically oriented copper rod electrodes, installed at two different sites. The RDC is measured through the Fall-of-Potential (FOP) method and is computed through simulation using CDEGS software. From the results, it revealed that the factors that contribute to the difference between the measured and computed values may be due to the gap between the grounding electrodes due to a rod coupler and the changes in surrounding soil during the driving of multiple rod electrodes. Consideration of these factors is crucial in reducing the discrepancy between the measured and computed RDC values.
Learn HTML: A refreshingly fun way to learn the foundations of HTML

Field: Computer Science (Physical Sciences)

Learn HTML is an interactive website with the purpose of teaching foundations of HTML. The website was designed to appeal to a teenage audience, ages 15 - 19 years old.\nThe nature of the website diverges away from the typical text based approach utilized in similar applications by abandoning a dependency on the heavy use of text to communicate information. Learn HTML, instead, features a strong use of graphic elements, visual metaphors, and a heavy focus on interactivity, all of which offer the user a visual representation of information.\nThrough interaction with the provided graphic elements and visual metaphors, the user is offered an enjoyable and engaging learning experience through which they are able to seamlessly gain knowledge through means of experiential learning.
The potential of emerging new therapeutics for the treatment of perivascular epithelioid cell tumors (PEComa)

Field: Medicine (Health Sciences)

Introduction: Perivascular epithelioid cell tumor (PEComa) constitutes a family of rare mesenchymal soft-tissue tumors. These tumors pose a significant diagnostic challenge, given their cytomorphology and characteristic co-expression of both melanocytic and myogenic markers. While most PEComas show benign behavior, a subset of PEComas can act malignantly. Historically, cytotoxic chemotherapy used in other soft-tissue sarcomas has shown little benefit. However, a growing understanding of the role of aberrant mTOR pathway activation in these tumors has yielded multiple reports of durable tumor responses and clinical benefit with mTOR inhibitors such as sirolimus, temsirolimus, and everolimus.Areas covered: We describe the histopathology, molecular features and differential diagnosis of the PEComa family and review available data on treatment strategies for localized and advanced PEComa. A literature search was performed using PubMed, American Society of Clinical Oncology, and ClinicalTrials.gov websites.Expert opinion: mTOR inhibitors are emerging as the standard approach to the management of advanced PEComa. Results of the clinical trial for advanced PEComa with ABI-009, a nanoparticle albumin-bound mTOR inhibitor, will provide the first prospective data of mTOR inhibition in PEComa, and may establish a relationship between genotype and outcome.
It's not only the game, it's also the player: The role of player personality in violent video game preference

Field: Psychology (Social Sciences)

In contrast to the effects of game content, violent video games have less been researched with regard to players' preferences for these games, and whether these preferences are related to certain personality characteristics. Using a novel brief and uni-dimensional self-report measure, the present research examined the role of personality factors and preferences for violent video games. A scale of five items was administrated in two studies that involved 292 and 180 respondents, respectively. The same scale with two additional items was presented to 190 respondents in the third study, which included measures revealed by prior research to be relevant for understanding violent video game motivation and preference. More specifically, we measured participants' trait aggression, the Dark Triad traits of psychopathy, Machiavellianism, and narcissism. To test for the scale's discriminant validity, trait empathy was also included. In line with other findings in the literature (e.g., Greitemeyer, 2015), results obtained with the self-report measure indicated that players with a propensity for games featuring violent themes show callous, impulsive and exploitative attributes, whereas narcissism was not a significant predictor. However, and as already suggested by some authors (Hartmann, Möller, & Krause, 2014), a lack of empathy was found to predict violent game preferences. The present findings are important with regard to future research on video games that should focus more on the players and their gaming motivation than on the effects of playing alone.
Analysis of digital profile of the financial market: a methodological approach of Russian Central Bank

Field: Economics, Econometrics and Finance (Social Sciences)

Currently the processes of digitalization have a strong impact on all spheres of society. Fundamental changes are observed in the economy due to digital expansion, implementing and usage of various modern technologies. The financial market as an essential part of the economy was the first thing that had to be digitalized. The Central Bank of the Russian Federation is actively engaged in the development of financial technologies in the financial market. Financial technologies can affect the availability of financial products and services, which in the future will contribute to sustainable development and increase the competitiveness of the entire financial sector. The Central Bank of the Russian Federation as a megaregulator monitors the financial market and currently a comprehensive system of relevant indicators is being formed. It is to assess the specifics of different profiles of the financial market, reflecting its most important characteristics, including the level of digitalization. It has been recognized to take a closer look at the description of such a concept as the digital profile of the financial market. To describe the entire financial market, we need comprehensive methodological approach that would reflect its characteristics. The research was conducted on the basis of studying the existing experience of analyzing the market of financial and technological services, its features, as well as methods and indicators for assessing the level of digitalization of the financial sector. The article proposed the concept of a digital profile of the financial market and developed a methodological approach for its analysis in order to implement the functions of the Central Bank of Russian Federation.
Application of a Model Based on a Variational Autoencoder for Music Generation

Field: Computer Science (Physical Sciences)

This study introduces a novel approach to music generation using a Variational Autoencoder (VAE) model, which incorporates style embeddings for enhanced control over the generated music. The model divides the latent space into content and style components, allowing users to specify desired musical styles. Experimentation demonstrates superior performance compared to traditional methods, with the model effectively capturing stylistic nuances and producing diverse musical compositions. Methodologically, the VAE employs a reparameterization trick and μ-forcing technique to ensure effective training and preservation of latent variables. The study concludes that the proposed approach surpasses baseline methods, offering users greater control and flexibility in generating music tailored to specific styles, thereby advancing the field of AI-driven music composition. The aim of the work is to develop a model for genre-specific music generation based on VAE neural networks.
Prevention of violence against children and adolescents: development and validation of an educational game

Field: Health Professions (Health Sciences)

ABSTRACT Objective: To develop and validate an educational game aimed at preventing violence against children and adolescents. Method: This is an applied methodological research conducted between April and August 2023. To develop the game, two workshops were initially held with 19 children and adolescents aged 10 to 14, participants in a social project within a community in a medium-sized city in the Midwest region of São Paulo state, Brazil. The workshops began with a screening of the short film LOU (Disney Pixar®), followed by expressive activities such as drawing and writing, as well as group discussions on the topic addressed. The game was developed by a research team comprising undergraduate and post-graduation students, based on data collected during the workshops with the target audience and a review of the relevant literature. This process highlighted different types of violence, reflections, and experiences shared by the participants, which directly contributed to defining the rules, characters, narrative, dynamics, and content of the game. Validation involved the participation of 12 expert judges, and a content validation index was used to measure agreement among evaluators. Results: A card game titled "Peacing: for a World without Violence" was developed and validated, achieving a Content Validation Index of 0.99 in the second validation round, indicating significant agreement among the judges. Conclusion: The educational game was considered validated by expert judges and proved to be an interactive and engaging tool with the potential to prevent violence among children and adolescents.
New records and updated distribution of the ant-like jumping spider genus Zuniga Peckham & Peckham, 1892 (Salticidae: Salticinae: Sarindini) in the Neotropics

Field: Agricultural and Biological Sciences (Life Sciences)

Galvis, William (2016): New records and updated distribution of the ant-like jumping spider genus Zuniga Peckham & Peckham, 1892 (Salticidae: Salticinae: Sarindini) in the Neotropics. Peckhamia 139 (1): 1-11, DOI: 10.5281/zenodo.3742275
Inner Core Belief Formation, Spiritual Practices, and the Willing-Doing Gap

Field: Arts and Humanities (Social Sciences)

Jesus taught we always live out what is in our heart. Our life is primarily directed by the deeply submerged core beliefs, which may often be very different from what we say we value or believe. One key component of inner formation is changing our core beliefs, with God's grace, and thus reducing the willing-doing gap. In the article, after identifying the problem, and highlighting Jesus’ focus on inner or heart formation, a basic overview of the concept of a belief is presented. Then ten principles or features about core beliefs and formation are proposed and clarified, followed by some implications for practice.
Memorable Messages in Campus Sexual Assault Prevention

Field: Social Sciences (Social Sciences)

This study examines the memorable messages retained by first-year Ball State University students who went through Think About It, an online sexual assault prevention training. A cross-section of first-year students were interviewed and iterative thematic analysis was used to develop themes in response to the research questions. The results suggest that memorable messages can impact individuals’ sense of identity during their socialization to a new university setting. The results also demonstrate the elements of online training design that can help motivate students to complete it. The findings of this study provide practical implications for improving campus sexual assault prevention training not only to comply with federal mandates, but also to better address student needs.
THE RELATIONSHIP BETWEEN ORGANIZATIONAL CLIMATE FOR INNOVATION AND INNOVATIVE WORK BEHAVIOR: MEDIATING ROLE OF EMPLOYEE ENGAGEMENT IN PAKISTAN

Field: Business, Management and Accounting (Social Sciences)

The purpose of this study is to empirically investigate the mediating result of employee engagement between organisational climate for innovation and innovative work behaviour. This study will have positive contribution towards theory. The tool used for data collection was closed-ended questionnaire. Results indicated that organisational climate for innovation and innovative work behaviour has a direct and indirect impact on innovative work behaviours. In this study, employee engagement has partial mediation impact between the organisational climate for innovation and innovative work behaviour. Approximately, 210 respondents participated in this study. The unit of analysis used in this study was employees. For practical implication, it will be useful for HR specialists who are concerned in increasing successful intercession that encourage employees to engage in innovative work behaviour. This paper offers contribution to the understanding of the relationship between the innovative work behaviour and organisational climate and mediating role of employee engagement.
Controversies in the contemporary understanding of comorbidity in psychiatry

Field: Medicine (Health Sciences)

The pre-therapeutic classification of comorbidity in chronic disease has been excessively broadened and distorted since A. R. Feinstein’s initial definition of the concept in 1970. Examinations more often than not establish the ‘comorbidity’ of depression and anxiety, instead of looking for a common pathological core of the two conditions. The ‘concurrence’ of symptoms of depression and anxiety, which is indeed very frequent in clinical practice, would be a more acceptable concept. It is even stranger to talk about the comorbidity of obsessive-compulsive disorder and schizophrenia: the question is what constitutes the primary disorder in such a combination. Schizophrenia or affective disorders are also very often categorized as being comorbid with personality disorders, without taking into account the manifestation of some behavioural personality disorders as pre-conditions or a prodrome of more serious disorders. For the purposes of treatment, taking into consideration the comorbidity of mental disorders and somatic illnesses is of paramount importance. Here we can mention, for example, the comorbidity of schizophrenia and AIDS or tuberculosis, recurrent depression and cardiovascular disease or diabetes, generalized anxiety disorder and asthma. The cases of comorbidity of affective disorders and abuse of alcohol or other psychoactive substances seem to be more disputable, since affective disturbances very often provoke alcohol excesses or temporary drug abuse not necessarily leading to dependency.
From “screen time” to screen times: Measuring the temporality of media use in the messy reality of family life

Field: Social Sciences (Social Sciences)

Abstract The discrepancy between children’s actual amount of viewing time and parents’ accounts of their concerns, rules, and parental mediation choices has been documented in empirical research, and typically interpreted through the lens of the Uses and Gratifications theory – showing how parents change their attitudes towards screen media in order to satisfy their own needs. Based on a qualitative longitudinal research project, including app-based media diaries, with 20 families with at least one child aged eight or younger, we aim to make two contributions to the literature. With regard to theory, we aim to highlight the heterogeneous and contingent ways of balancing the place of digital media in children’s lives that arise from parents navigating screen time discourses, social pressures, and daily schedules. With regard to methods, we argue for the combination of qualitative data and app-based media diaries to contextualise and interpret potential discrepancies between reported screen time and parental anxieties or hopes about digital media.
Pornographie, nouveaux médias et intimité normative dans les discours sur l’hypersexualisation des jeunes

Field: Social Sciences (Social Sciences)

In recent years, the hypersexualization of youth has generated many discourses, anxieties, and control measures in Québec as well as in most Western societies. This article bases itself on a critical analysis of the discourses produced in francophone Québec by media institutions and their specific actors to highlight the ways in which the discursive production of hypersexualization as a social problem mobilizes pornography and new media; it also highlights the issues raised by this mobilization. One of these issues is a normative intimacy—one that seeks to preserve hierarchized social and sexual relations—that would be threatened by an online pornography that blurs the lines between public and private as well as between an adult sexuality and the world of youth.
Sexual reproductive biology of the endangered Japanese red maple ( Acer pycnanthum )

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Japanese red maple, Acer pycnanthum , is an endangered wetland species having dioecious sex expression. Prior studies conclude that land development has caused severe loss of habitat, and seedling regeneration is rare. However, information is lacking on sexual reproduction, which is the first critical stage of regeneration. My research objective was to describe flowering and fruiting characteristics of Japanese red maple, focusing on tree sizes at the onset of flowering, factors affecting flowering regularity and fruit abundance, periodicity of fruit production, and sex ratio. In a study of a young population, Japanese red maple initiated flowering at a small size under 100% light intensity. Initiation of flowering occurred at relatively lower height in males than females, and males flowered more regularly than females. A survey of 1,106 clones from 46 natural populations revealed that male clones were significantly more abundant than female clones. In a 4‐year study of mature populations, nearly all clones flowered regularly, and fruit abundance of dominant females was typically high. Fruit abundance at the population level also remained high, although fruit abundance of individual female clones varied year by year. Therefore, sexual reproductive ability is highly vigorous. Sex ratio exhibited a major deviation from a 1:1 ratio in populations with a small number of clones. In conservation planning, we should prioritize avoidance of an unbalanced sex ratio by increasing population sizes. In addition, populations having many clones >40 cm dbh with large, well‐lighted crowns have a high potential of regular and abundant seed production.
Evaluating an electronic plagiarism detection service

Field: Social Sciences (Social Sciences)

Plagiarism by students is seen as an increasing problem. The fear is that students will use the internet to obtain analysis, interpretation or even complete assignments and then submit these as their own work. Electronic plagiarism detection services may help to prevent such unfair practice but, in doing so, they create a new problem: certifying the absence of plagiarism. This article reports the results of an evaluation of one such service within an interdisciplinary school of social sciences. The article describes how the system works and the experiences of staff and students in using the service, together with an evaluation of the data generated. The key findings are that the service did identify examples of poor scholarship and unfair practice that had been missed under the usual marking system but that rigorously checking every script for plagiarism was impractical. Trust and student honesty thus remain central to a successful academic system.
Data from Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma

Field: Medicine (Health Sciences)

<div>Abstract<p>Tumor suppressor mutations in head and neck squamous cell carcinoma (HNSCC) dominate the genomic landscape, hindering the development of effective targeted therapies. Truncating and missense mutations in <i>NOTCH1</i> are frequent in HNSCC, and inhibition of PI3K can selectively target <i>NOTCH1</i> mutant (<i>NOTCH1<sup>MUT</sup></i>) HNSCC cells. In this study, we identify several proteins that are differentially regulated in HNSCC cells after PI3K inhibition based on <i>NOTCH1<sup>MUT</sup></i> status. Expression of Aurora kinase B (Aurora B), AKT, and PDK1 following PI3K inhibition was significantly lower in <i>NOTCH1<sup>MUT</sup></i> cell lines than in wild-type <i>NOTCH1</i> (<i>NOTCH1<sup>WT</sup></i>) cells or <i>NOTCH1<sup>MUT</sup></i> cells with acquired resistance to PI3K inhibition. Combined inhibition of PI3K and Aurora B was synergistic, enhancing apoptosis <i>in vitro</i> and leading to durable tumor regression <i>in vivo</i>. Overexpression of Aurora B in <i>NOTCH1<sup>MUT</sup></i> HNSCC cells led to resistance to PI3K inhibition, while Aurora B knockdown increased sensitivity of <i>NOTCH1<sup>WT</sup></i> cells. In addition, overexpression of Aurora B in <i>NOTCH1<sup>MUT</sup></i> HNSCC cells increased total protein levels of AKT and PDK1. AKT depletion in <i>NOTCH1<sup>WT</sup></i> cells and overexpression in <i>NOTCH1<sup>MUT</sup></i> cells similarly altered sensitivity to PI3K inhibition, and manipulation of AKT levels affected PDK1 but not Aurora B levels. These data define a novel pathway in which Aurora B upregulates AKT that subsequently increases PDK1 selectively in <i>NOTCH1<sup>MUT</sup></i> cells to mediate HNSCC survival in response to PI3K inhibition. These findings may lead to an effective therapeutic approach for HNSCC with <i>NOTCH1<sup>MUT</sup></i> while sparing normal cells.</p>Significance:<p>Aurora B signaling facilitates resistance to PI3K inhibition in head and neck squamous cell carcinoma, suggesting that combined inhibition of PI3K and Aurora kinase is a rational therapeutic strategy to overcome resistance.</p></div>