jimnoneill/paper-to-field-training huggingface dataset:
An efficient zinc acetate dihydrate-catalyzed green protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones

Field: Chemistry (Physical Sciences)

By condensation from substituted carbonyl compounds and anthranilamide under toluene reflux conditions, a wide range of 2,3-dihydroquinazolin-4(1H)-ones were produced in fair to good yields with the use of a Lewis acid catalyst Zn(OAc)2•2H2O (10 mol%), which is inexpensive, accessible, and environmentally friendly.All the synthesized compounds were properly described using melting point, IR, NMR, and mass spectral studies, and the findings were compared with information from the earlier literature.The new method has a number of advantages over the traditional methods for the synthesis of divergent 2,3-dihydroquinazolin-4(1H)-ones, including a higher product conversion, a wide substrate range, and the absence of undesirable side products.Aliphatic, heteroaromatic and aromatic carbonyl compounds were well tolerated under the optimized reaction conditions.
OVER-EXPRESSION OF FGFR2 IIIC ISOFORM ENHANCES THE GROWTH OF PANCREATIC CANCER

Field: Medicine (Health Sciences)

Background: Fibroblast growth factor receptors (FGFRs) possess IIIb and IIIc isoforms, due to the alternative splicing of the carboxy-half of third immunoglobulin (Ig)-like domain. IIIb isoforms of FGFRs are mainly localized in epithelial cells, whereas IIIc isoforms are expressed in mesenchymal cells. We previously reported that expression of FGFR2 IIIb isoform in pancreatic cancer correlates with venous invasion and VEGF-A expression. In the present study, we examined expression and the role of FGFR2 IIIc in pancreatic cancer. Methods: FGFR2 IIIc and IIIb mRNA expression levels were examined in six pancreatic cancer cell lines by real-time PCR. FGFR2 IIIc cDNA was subcloned into pIRES2-EGFP vector and FGFR2 IIIc stably transfected KLM-1 cells were prepared. Growth rates of the FGFR2 IIIc transfected KLM-1 cells were compared with mock cells. Immunohistochemical analysis using anti-FGFR2 IIIc antibody was performed on 47 pancreatic cancer cases. Results: FGFR2 IIIc and IIIb expression was detected in all pancreatic cancer cell lines. FGFR2 IIIc was low in KLM-1, Capan-1, PK-1 and PK-8, whereas IIIb was highly expressed in the cells. Growth rate of FGFR2 IIIc stably transfected KLM-1 cells was higher than those of mock cells. FGFR2 IIIc was not localized in exocrine and endocrine components of normal pancreas, but it was strongly localized in cancer cells of 32 of 47 cases (68%). Conclusion: FGFR2 IIIc was expressed in many of pancreatic cancer cases and its expression may correlate with the cancer cell growth.
A new procedure to determine equivalent strut of infill walls with openings for engineering applications

Field: Engineering (Physical Sciences)

In architecture, design of doors and windows for functional requirements, circulation, natural light and ventilation, aesthetics and view is inevitable. Parameters such as size, location and aspect ratio of the openings change the seismic behaviour of infilled frames. Ignoring these parameters in structural analysis may lead to substantial inaccuracy in predicting the lateral stiffness, strength and ductility of the frame. Despite numerous experimental and numerical studies on perforated infill walls in recent decades, the related provisions are rare in seismic codes and engineers tend not to use their results in analysis and design due to their complexity. The main purpose of this work was to propose a new procedure to determine the specifications of equivalent struts of perforated infill walls for engineering applications considering structural stiffness and load path based on valuable existing literature. All common types of windows used in architectural design (central openings, eccentric openings, corner openings and full-length openings) were investigated and the literature was reviewed for reduction factors of equivalent struts of infill walls with openings. Where there was a lack of studies, 27 micro models and 14 macro models were analysed to achieve the purpose of the research. A comprehensive and practical algorithm based on the size and location of openings is proposed.
Integration of Palliative Care Standards in the Icu at Kaiser Permanente Medical Center in Hawaiʻi

Field: Health Professions (Health Sciences)

Palliative care is medical care that enhances quality of life for patients living with serious advanced illness, by helping to align their treatment choices with their values. It has traditionally been used late in the care of patients, when all life-prolonging interventions have failed and death is imminent. Many chronically ill patients have not designated or discussed their care preferences with a surrogate decision maker. This omission can sometimes result in unwanted, aggressive treatments. There is evidence that demonstrates both the benefits of early identification of Goals-of-Care that are aligned with the patient’s wishes, and the importance of end-of-life care in the intensive care unit (ICU). A structured, palliative care, quality-improvement program was implemented and evaluated in the ICU at Kaiser Permanente Hawaii. The goal was to incorporate basic palliative care principles into the routine ICU care, and to increase the numbers of palliative care consultations as necessary, thereby enhancing the utilization of existing palliative care services and improving end-of-life care in the ICU. Pre- and post-interventional data showed an increase in the early identification of code status and Goals-of-Care, which, in turn, led to increased early ICU family meetings and also increased the numbers of palliative care consultations. Both the ICU length of stay and hospital length of stay decreased during the post-interventional period. The results from the family and nurse’s surveys were generally positive, and understanding of the process by the nursing staff showed improved trends throughout the interventional phase. It was concluded that integration of a structured palliative care program in the ICU was beneficial for patients, families and the ICU staff.
The Unstated Climax of Catullus 64

Field: Arts and Humanities (Social Sciences)

Definition of the class of poem which modern scholarship has agreed to describe by the convenient, if unauthorized, title of epyllion has never proved altogether successful. The claim has commonly been made that Catullus' sixty-fourth poem may be accepted as the type and that all or most of the features revealed in it may be assumed to exist more or less completely realized in earlier examples from the Alexandrian period: in particular, that the epyllion always possesses a secondary story enclosed within the primary one.
Unresolved Legacies

Field: Social Sciences (Social Sciences)

In Canada, aboriginal legacies in landscapes and their implications for land use planning for biodiversity conservation remain poorly acknowledged. Similarly, inter-cultural conversations on values about and priorities for biological resources and habitat protection remain under-developed. This essay begins with a rhetorical question. Will it be possible to forge successful ecosystem recovery strategies, to maintain all elements of local biological diversity through land use planning, without far deeper cognizance of the aboriginal legacies in Canadian landscapes? I do not think so. This discussion, from the drier enclaves on the south coast of British Columbia, centres on a federally funded ecosystem recovery team in the first four years of its operation from 1999 to 2003 and the near total lack of outreach to, and engagement with, aboriginal people and First Nations. These were the same years as the final phase of development of Canada’s relatively weak Species At Risk Act (SARA).2
Reverse transcription priming methods affect normalisation choices for gene expression levels in oocytes and early embryos

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Mammalian oocytes and embryos rely exclusively on maternal mRNAs to accomplish early developmental processes. Since oocytes and early embryos are transcriptionally silent after meiotic resumption, most of the synthesised maternal mRNA does not undergo immediate translation but is instead stored in the oocyte. Quantitative RT-PCR is commonly used to quantify mRNA levels, and correct quantification relies on reverse transcription and the choice of reference genes. Different methods for reverse transcription may affect gene expression determination in oocytes. In this study, we examined the suitability of either random or oligo(dT) primers for reverse transcription to be used for quantitative RT-PCR. We further looked for changes in poly(A) length of the maternal mRNAs during oocyte maturation. Our data indicate that depending on the method of reverse transcription, the optimal combination of reference genes for normalisation differed. Surprisingly, we observed a shortening of the poly(A) tail lengths of maternal mRNA as oocytes progressed from germinal vesicle to metaphase II. Overall, our findings suggest dynamic maternal regulation of mRNA structure and gene expression during oocyte maturation and early embryo development.
Voices in Molecular Pharmaceutics: Meet Dr. Nasim Shadmani Who Utilizes Cell Penetrating Peptides and Nanoparticles for Targeting Hard-to-Reach Areas of the Body Including the Brain

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTVoices in Molecular Pharmaceutics: Meet Dr. Nasim Shadmani Who Utilizes Cell Penetrating Peptides and Nanoparticles for Targeting Hard-to-Reach Areas of the Body Including the BrainNasim Shadmani*Nasim ShadmaniZanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, 45139-56184 Zanjan, IranDepartment of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, 45139-56184 Zanjan, Iran*Email: [email protected]More by Nasim ShadmaniView Biographyhttps://orcid.org/0000-0003-1951-8240Cite this: Mol. Pharmaceutics 2024, 21, 3, 996–998Publication Date (Web):February 1, 2024Publication History Received18 December 2023Published online1 February 2024Published inissue 4 March 2024https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.3c01212https://doi.org/10.1021/acs.molpharmaceut.3c01212editorialACS PublicationsCopyright © Published 2024 by American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views473Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSUBJECTS:Central nervous system,Drug delivery,Nanoparticles,Peptides and proteins,Pharmaceuticals Get e-Alerts
Peptide Histidine-Methionine Immunoreactivity in Plasma and Tissue from Patients with Vasoactive Intestinal Peptide-Secreting Tumors and Watery Diarrhea Syndrome

Field: Medicine (Health Sciences)

The presence of peptide histidine-methionine (PHM)-like peptides has been determined in plasma and tumor specimens from patients with vasoactive intestinal peptide (VIP)-secreting tumors and the watery diarrhea syndrome. All patients had strikingly elevated plasma concentrations of PHM immunoreactivity (median, 1800; range, 500-6800 pmol/liter; n = 12), which were higher than those of VIP (median, 235; range, 50-580 pmol/liter). In patients with other endocrine and nonendocrine pancreatic tumors, plasma PHM concentrations were not significantly different from normal (median, 20; range, 5-60 pmol/liter; n = 28). Plasma samples from patients with diarrhea due to other illnesses also had PHM concentrations that were not significantly different from normal (median, 40; range, 10-80 pmol/liter; n = 23). The gel chromatographic profiles of plasma and tumor extracts from patients with VIP-secreting tumors revealed the presence of at least two molecular forms that reacted with an antiserum directed to the N-terminus of PHM (SY1). The later peak (Kav, 0.50-0.53) corresponded in position to synthetic PHM and also reacted with the PHM-specific antiserum (SY2). The earlier peak (Kav, 0.30-0.37), not reactive with antiserum SY2, corresponded to a large molecular form of PHM-like immunoreactivity previously identified as the predominant form in normal human stomach and plasma, though not in the rest of the intestinal tract. The neuroendocrine nature of the tumors was confirmed by the demonstration of immunostaining with a battery of antisera to neuroendocrine markers. Immunocytochemistry revealed the presence of both VIP and PHM in tumor cells. The presence of high circulating concentrations of PHM-like immunoreactivity in patients with VIP-secreting tumors, as measured with a PHM N-terminus-directed antiserum, SY1, suggests that use of this type of antiserum may provide valuable information in the diagnosis of such tumors. The contribution of the PHM-like peptides to the features of this syndrome is not known.
Type IIB Flux Vacua and Tadpole Cancellation

Field: Physics and Astronomy (Physical Sciences)

Abstract We consider flux vacua for type IIB orientifold compactifications and study their interplay with the tadpole‐cancellation condition. As a concrete example we focus on , for which we find that solutions to the F‐term equations at weak coupling, large complex structure and large volume require large flux contributions. Such contributions are however strongly disfavored by the tadpole‐cancellation condition. We furthermore find that solutions which stabilize moduli in this perturbatively‐controlled regime are only a very small fraction of all solutions, and that the space of solutions is not homogenous but shows characteristic void structures and vacua concentrated on submanifolds.
The Pocky Body: Part II

Field: Arts and Humanities (Social Sciences)

It is a curious fact that when the London theatres reopened after the major bubonic plague epidemic of 1603, a cluster of plays emerged which, through their imagery, allusions and themes, directed their attention not to 'the' plague but to the venereal sister plague — the French Pox. Prostitutes, courtesans, panders, bawds, and lecherous males with their attendant 'infection' became commonplace types on the Jacobean stage for a number of interrelated reasons that it will be the purpose of this chapter to explore.
Comparative genomics and transcriptomics of Xanthomonas campestris : Session 3- Physiologie, génétique et génomique des bactéries

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The Xanthomonas campestris species causes different diseases on a wide range of Brassicas and is composed of at least four pathovars (campestris, incanae. raphani. unnamed). This species encompasses both vascular and non-vascular pathogens. A comparative genomic analysis of X campestris diversity was performed at the intraspecific and intrapathovar levels by sequencing more than 40 strains. Structural genome annotation was performed and benefited from deep sequencing of small and large RNAs. This approach allowed the exact determination of transcriptional start sites and the identification of small noncoding RNAs. We also used RNA sequencing to characterize the type III regulon in several strains and could identify novel type 111 effectomes. Core and variable genomes and type 111 effectomes were determined. These results evidenced an unsuspected genomic diversity in this species. The latest progress in this project will be presented. (Texte intégral)
The perfect states of Keratinomyces ajelloi Vanbreuseghem, Trichophyton terrestre Durie & Frey and Microsporum nanum Fuentes.

Field: Immunology and Microbiology (Life Sciences)

During investigations of soil samples from various districts in the West of Scotland using Vanbreuseghem's (1952) hair-bait method, Keratinomyces ajelloi, Trichophyton terrestre, Microsporum gypseum and Arthroderma curreyi were isolated. These fungi, and Microsporum nanum isolated from ringworm-infected pigs in Kenya, have been studied in culture on unsterilised soil. Descriptions are given of the perfect stages of K. ajelloi and M. nanum which were obtained in soil culture and that of T. terrestre which arose spontaneously in an agar slope culture. It is proposed that the perfect forms of K. ajelloi and T. terrestre be included in the genus Arthroderma Currey as A. uncinatum sp. nov. and A. quadrifidum sp. nov. respectively, and that the perfect form of M. nanum be put in the genus Nannizzia Stockdale as N. obtusa sp. nov.
Prepartum plane of dietary energy alters hepatic expression of inflammatory and fatty acid oxidation genes in dairy cows

Field: Veterinary (Health Sciences)

Recent data suggest prepartum plane of energy intake and inflammation may play a role in development of fatty liver and associated disease in dairy cows. Therefore, our objective was to determine transcriptional profiles of mRNA for inflammation‐associated genes in the liver. Eighteen multiparous cows were assigned to 1 of 3 prepartum dietary treatments. Diets supplied 80 (80E), 100 (100E) or 150% (150E) of NRC (2001) energy recommendations for non‐lactating, late‐gestation cows. After parturition, all cows were fed one lactation diet. Total RNA was isolated from liver tissue obtained via biopsy on d ‐65, ‐30, ‐14, 1, 14, and 28 relative to parturition. Quantitative real‐time PCR was used to determine expression of mRNA for each gene relative to a control. Genes measured were TNFA , IL1B , SAA3 , NFKB , ACOX1 , CPT1A , PGC1A , PPARA , SREBF1 , PC , NR1H3 , and HNF4A . Expression of IL1B was nearly 3 times greater (P < .001) for 150E cows than 80E or 100E cows on d 14. Relative expression of TNFA tended to be greater (P = 0.06) on d ‐14 for 150E than either 80E or 100E cows. NFKB expression was greater (P = 0.05) and SREBF1 lower (P < 0.001) in 80E cows compared to 150E cows on d ‐30. Relative expression of ACOX1 , CPT1A , PPARA , NR1H3 , and HNF4A was greater (P < 0.01) in 100E cows than in 150E cows on d 14. Over‐consumption of energy prepartum elicited an inflammatory response in liver and decreased expression of genes related to fatty acid oxidation.
High Brightness Beams and Applications

Field: Physics and Astronomy (Physical Sciences)

This paper describes the present research on attaining intense bright electron beams. Thermionic systems are briefly covered. Recent and past results from the photoinjector programs are given. The performance advantages and difficulties presently faced by researchers using photoinjeetors are discussed. The progress that has been made in photocathode materials, both in lifetime and quantum efficiency, is covered. Finally, a discussion of emittance measurements of photoinjector systems and how the measurement is complicated by the nonthermal nature of the electron beam is presented.
Internationalising business education curriculum in a 'flat world': the scope and constraints

Field: Business, Management and Accounting (Social Sciences)

This study empirically analyses the scope and constraints of internationalising business education curriculum in the USA. Using primary data, we evaluate the extent to which faculty members engage in internationalisation activities, the potential job risk attached to the process and the university support. Additionally we attempt to address the following three questions: What are the current approaches to business curriculum internationalisation? What are the constraints? What other effective and cost efficient approaches can faculty members use? Results point to compelling evidence that majority of the faculty members are currently internationalisation their curriculum. However, the preferred approach is by infusing cross–cultural elements in the course content rather than involve international travel. Nonetheless, they face cost constraints and lack of proper international experiences. Furthermore job risk plays a significant role in a faculty's decision to internationalise.
Determination of Neuro-Muscular, Circulatory, Pulmonary Function and Psychological Fitness among the Second Year Indian Students

Field: Health Professions (Health Sciences)

The Principal aimed to revaluate and detect the methods hand grip strength, pulse, arterial pressure, lung function and psychological fitness between male and female. The observation was based on some groups of Indian students of Perm State Medical University and finding the average values between these tests. Keywords: Maximum strength; Average Vital capacity; Arterial pressure
Antiphospholipid syndrome and factor V Leiden. Three cases with recurrent venous thrombosis.

Field: Medicine (Health Sciences)

Recurrent thrombosis is a common complication of various rheumatic disorders and is part of the definition of antiphospholipid syndrome. We report three cases of recurrent venous thrombosis due not only to antiphospholipid syndrome with a normal activated partial thromboplastin time but also to resistance to activated protein C caused by the factor V Leiden mutation. These three cases confirm that thrombotic disease is frequently multifactorial and suggest that resistance to activated protein C should be looked for routinely in patients with suggestive clinical manifestations, particularly when standard clotting tests are normal.
Feeding Behavior of Finishing Pigs under Diurnal Cyclic Variation in Ambient Temperature

Field: Agricultural and Biological Sciences (Life Sciences)

The impact of cyclic heat stress (CHS) and lighting events on pig feeding behavior (FB) was investigated. The FB of 90 gilts was recorded in real time under two ambient temperatures (AT): thermoneutrality (TN, 22 &deg;C) or CHS (22&deg;/35 &deg;C). The day was divided into four periods: PI (06-08 h); PII (08-18 h); PIII (18-20 h); and PIV (20-06 h). Automatic and Intelligent Precision Feeders recorded each feed event for each pig. An estimated meal criterion (49 minutes) was used to calculate the FB variables. Feed behavior in both ATs followed a circadian pattern. The CHS reduced the feed intake by 6.9%. Pigs prioritized feed intake during the coolest hours of the day; however, nocturnal cooling did not allow the pigs to compensate for the reduced meal size due to CHS. The highest meal size and most of the meals were observed during the lighting-on period. Pigs reduced their interval between meals during periods II and III. The lighting program increased the meal size when the lights were switched on and reduced the meal size when the lights were switched off. Thus, the dynamics of the FB were largely influenced by AT, while the meal size was affected by the lighting program.