jimnoneill/paper-to-field-training huggingface dataset:
Subcutaneous Panniculitis-like T Cell Lymphoma Diagnosed with a Slowly Progressive Course: A Case Report.

Field: Medicine (Health Sciences)

Panniculitis is an inflammation that occurs in subcutaneous adipose tissue. Panniculitis includes physical panniculitis (e.g., traumatic) and infectious panniculitis (e.g., bacterial, fungal, subcutaneous panniculitis-like T cell lymphoma [SPCTL], etc.). Accurate diagnosis is crucial due to similar clinical presentation of all types of panniculitis. Here, we report a case of SPCTL which was initially diagnosed with traumatic panniculitis. A 15-year-old male patient was admitted to a previous hospital due to a progressively enlarged right flank and inguinal mass after an abdominal bruise. He was initially diagnosed with traumatic panniculitis, but the mass expanded throughout the chest and abdomen accompanied by a fever of over 11 months. Computed tomography (CT) revealed a subcutaneous mass in the anterior chest and abdominal wall. Fludeoxyglucose F18 (FDG) uptake was observed at those lesions using FDG-positron emission tomography (PET). A biopsy of the mass lesion was performed, during which SPCTL was diagnosed based on pathological examination. He was initially treated with prednisolone and cyclosporine A for two weeks. His fever went down, but subcutaneous mass in the chest and abdominal wall persisted. Therefore, he received a cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen. After 6 courses of CHOP, CT revealed no disease evidence. He remained in complete remission at 30 months of therapy.
[Preparation and identification of monoclonal antibodies against different epitopes on human zeta globin chain].

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Three hybridoma cell lines secreting anti-zeta mAb were established, designated as 1A12, 3H9 and 4D11, respectively. Both of 3H9 and 4D11 mAbs belonged to IgG1 isotype and mAb 1A12 to IgG2a. All the mAbs could bind specifically to recombinant zeta and natural zeta globin from hemolysate of --(SEA) gene carrier. In addition, 1A12 and 3H9 mAbs could recognize different epitopes on zeta globin, suggesting the possibility of developing a detection system for screening alpha-thalassemia with these mAbs.
Preparation, Characterization, and Mechanism of Antifreeze Peptides from Defatted Antarctic Krill (Euphausia superba) on Lactobacillus rhamnosus

Field: Agricultural and Biological Sciences (Life Sciences)

Defatted Antarctic krill powder is the main by-product in the manufacturing of krill oil. Exploring a high value-added approach for utilizing this protein-rich material has received much attention in research and industry. Given this, the preparation and primary characterization of antifreeze peptides from defatted Antarctic krill (AKAPs) were carried out in this study. The cryoprotective effect of AKAPs on Lactobacillus rhamnosus ATCC7469 was also investigated. The results showed that Protamex was the optimum protease for AKAP preparation from defatted Antarctic krill. AKAPs were found to be rich in short peptides, with the MW ranging from 600 to 2000 Da (69.2%). An amino acid composition analysis showed that AKAPs were rich in glutamic acid (18.71%), aspartic acid (12.19%), leucine (7.87%), and lysine (7.61%). After freezing, the relative survival rate of Lactobacillus rhamnosus in the 1.0 mg/mL AKAP-treated group (96.83%) was significantly higher than in the saline group (24.12%) (p < 0.05). AKAPs also retarded the loss of acidifying activity of L. rhamnosus after freezing. AKAPs showed even better cryoprotective activity than three commercial cryoprotectants (sucrose, skim milk, and glycerol). In addition, AKAPs significantly alleviated the decrease in β-galactosidase and lactic dehydrogenase activities of L. rhamnosus (p < 0.05). Furthermore, AKAPs effectively protected the integrity of L. rhamnosus cell membranes from freezing damage and alleviated the leakage of intracellular substances. These findings demonstrate that AKAPs can be a potential cryoprotectant for preserving L. rhamnosus, providing a new way to use defatted Antarctic krill.
International consumer insights into the desires and barriers of diners in choosing healthy restaurant meals

Field: Social Sciences (Social Sciences)

Overweight and obesity are global public-health problems and unhealthy restaurant meals have been identified as one contributing factor. Given the increase in restaurant meals and the number of chefs and restaurants throughout the world, small changes in restaurant meals can have a large public health impact. However, to ensure that chefs and operators are able to provide changes that diners will accept and find appealing, an understanding of diners' desire for healthier menus items and the barriers faced in choosing healthier meals is required. As such we conducted an international consumer study to identify these barriers and needs. A cohort of restaurant diners was recruited from ten countries: United Kingdom, United States of America, Germany, Poland, Turkey, Russia, Brazil, South Africa, Indonesia and China (n = 5000, aged 18–65 years, 50% females). Participants completed a comprehensive web-based questionnaire on aspects related to healthy eating at restaurants. Globally only 18% of the sampled diners were strongly satisfied with current healthy options on restaurant menus. Among the diners there was a preference to have "slightly healthier" options. The top 3 small changes that these diners wanted to see included on restaurant menus to make them healthier included: steamed, baked or grilled instead of fried, fresh ingredients used, and served with plenty of vegetables. Taste, price and satiation were seen as key barriers to current healthy options. Diners had clear preferences for when they wanted to see healthy items on the menu in terms of time of day, time of the week and occasions. Country, age and gender had a large influence on preferences, while personal factors such as diet type, family status and food reactions had minimal influence. In the current study, diners were largely unsatisfied with current healthy options and clear barriers and triggers for healthier meals were identified. Nutritionists, dietitian, chefs and managers working for restaurants and other out of home food services can leverage these insights to provide healthier and appealing meals.
Feminist theology as dogmatic theology

Field: Arts and Humanities (Social Sciences)

The word 'dogmatic' may seem an odd choice for the title of this consideration of feminist theology. It could fairly be argued that feminists have themselves not been particularly favourable towards things dogmatic, sharing with the wider ethos of Western thought a modern suspicion of that which is handed down from some other place than here, and which does not bear thinking about but is only to be taken as read. Not only have feminists participated happily in the shredding of previously reputable dogmas with the use of critical reason, but many of their writings also reveal a hesitancy about being dogmatic in turn, an apology for what might appear to be so, even a self-effacement from making what might be taken as dogmatic claims. Nevertheless there is an important sense in which feminist theology undertaken by Christian women has been and continues to be dogmatic. It is to investigate the senses in which this is so that this chapter is written.
The Static Lattice Model of Hardy and Bullough Applied to the Noble Metals to Calculate Divacancy Interaction Energies and Relaxations

Field: Materials Science (Physical Sciences)

The discrete lattice method of Hardy and Bullough (1967) and Bullough and Hardy (1968) is applied to the noble metals to obtain estimates of the relaxations around a vacancy and of the near neighbour divacancy interaction energy. Accuracy is improved on earlier work by use of a point-formula integration technique. It is found that the soft phonon spectrum of gold leads to large relaxations and a divacancy interaction energy which is about half the single vacancy formation energy. It is therefore concluded that the model is too simplistic to describe the single and divacancy situations in gold, and may also not be accurate for copper and silver, though for the lighter elements the results are better.
Examining quality of care for individuals treated for mental health using the HEDIS mental health quality measures

Field: Health Professions (Health Sciences)

Objective: This descriptive study examined the quality of care received by individuals with serious mental illness observed in clinical care using established Healthcare Effectiveness Data and Information Set (HEDIS) measures for individuals with serious mental illness.Methods: Administrative claims (Medicaid, Medicare, and commercial) from a national health and well-being company were used to identify adults with schizophrenia or bipolar disorder. Performance rates for five HEDIS mental health quality measures were computed. Sub-group analyses examined each HEDIS measure by those who were medication adherent vs non-adherent, and by typical vs atypical antipsychotics.Results: Eighty-nine percent of the Medicaid population received a diabetes screening (vs 79% for national benchmark Medicaid rates), 81% (vs 69%) received monitoring for diabetes, 88% (vs 79%) received monitoring for cardiovascular disease, 63% (vs 60%) were adherent with antipsychotic medication, and 34% (vs 61%) had a follow-up visit with a mental health practitioner within 30 days of a discharge. The rates for individuals with Medicare coverage were similar or marginally higher than those reported for those with Medicaid coverage, while rates for the commercially insured population were lower than the other groups.Conclusions: Most (>65%) individuals with serious mental illness received the recommended screening and monitoring for diabetes and cardiovascular disease. Barriers to and reasons for lack of follow-up should be investigated to guide future interventions to improve follow-up after hospitalization for individuals with serious mental illness.
Privately retrieve data from large databases

Field: Computer Science (Physical Sciences)

We propose a general efficient transformation from Private Information Retrieval (PIR) to Symmetrically Private Information Retrieval (SPIR). Unlike existing schemes using inefficient zero-knowledge proofs, our transformation exploits an efficient construction of Oblivious Transfer (OT) to reduce the communication complexity which is a main goal of PIR and SPIR. The proposed SPIR enjoys almost the same communication complexity as the underlying PIR. As an independent interest, we propose a novel homomorphic public-key cryptosytem derived from Okamoto-Uchiyama cryptosystem and prove its security. The new homomorphic cryptosystem has an additional useful advantage to enable one to encrypt messages in changeable size with fixed extension bits. Based on the proposed cryptosystem, the implementation of PIR/SPIR makes PIR and SPIR applicable to large databases.
Prognostic implications of preoperative versus postoperative circulating tumor DNA in surgically resected lung cancer patients: a pilot study

Field: Medicine (Health Sciences)

Background: Recent studies of advanced lung cancer patients have shown that circulating tumor DNA (ctDNA) analysis is useful for molecular profiling, monitoring tumor burden, and predicting therapeutic efficacies and disease progression. However, the usefulness of ctDNA analysis in surgically resected lung cancers is unclear.
[Comparative efficiency of detection of the causative agent of urogenital chlamydiasis by immunofluorescence, polymerase chain reaction, and dot immunoassay].

Field: Medicine (Health Sciences)

The diagnostic efficiency of three diagnostic kits--two commercial (for direct immunofluorescent test (DIFT) and polymerase chain reaction (PCR) and one predeveloped experimental dot-ELISA--was compared. For this, specimens (cervical or urethral scrapes) from 225 patients with suspected or verified urogenital chlamydiasis were analyzed. Dot-ELISA was shown to have a higher sensitivity and a higher specificity than both commercial kits. The coincidence of positive and negative results of dot-ELISA with DIFT and PCR was 98.6 +/- 1.4 and 100%, respectively. In addition, dot-ELISA on the "Amersham" membrane could detect cases of the disease by 7 and 1.2 times, as compared with PCR and DIFT, respectively. The prospects of the dot-ELISA kit for the rapid, simple, and cheap diagnosis of urogenital chlamydiasis are discussed.
Molecular cloning and characterization of a cDNA encoding the prophenoloxidase gene in Bombyx mandarina

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Phenoloxidase plays an important role in defense mechanisms in insect immunity. The complemental deoxyribonucleic acid (cDNA) of Bombyx mandarina prophenoloxidase (PPO) gene was cloned by means of reverse transcription polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends (RACE). The cDNA was 2 134 bp in length and contained an open reading frame (ORF) of 2 082 bp which encoded 693 amino acid residues.The deduced amino acid sequence showed a high identity to the reported sequence of PPO2 from other Lepidopterous insects and shared the typical structural features of PPO from other insects. The results of RT-PCR showed that PPO mRNA was expressed in the integument, haemocyte, head, testis, ovary, fat body and midgut of 5th instar larvae and at different developmental stages of B. mandarina. These results provide molecular basis for further studying the function of ppo gene in B. mandarina.
Using functional genetics and epigenetics to dissect the molecular architecture of schizophrenia

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Schizophrenia is a severe neuropsychiatric disorder which is within the top ten causes of disability in the developed world. While we currently do not fully understand the aetiology of schizophrenia, a wealth of genetic, epigenetic, and epidemiological evidence suggests a neurodevelopmental origin, and that dysregulation of the immune system and infection can play a role in aetiology. This has been supported throughout the last decade and the “big data” revolution. Genetic and epigenetic data gathered through genome and epigenome wide association studies, have identified over 100 genetic risk loci for schizophrenia. Further to this there have been a number of epidemiological studies examining the effect of environmental risk factors to schizophrenia. However, many of these genetic, epigenetic, and environmental risk factors have no clear mechanism by which they cause disease. Many of these studies published present evidence for the “risk factor” involvement but fail to validate their findings in model systems, to establish how these risk factors cause disease. The main aim of this thesis was to develop functional assays and methods to validate genetic, epigenetic, and environmental risk factors in human cellular based models to elucidate how these risks can contribute to disease. From this work I have developed a protocol for knocking out risk genes, and have identified a role for the schizophrenia risk gene AS3MT in neuronal development. I have also developed several pipelines to validate epigenome wide association studies, and link how changes in DNA methylation can affect gene expression, at both the regional level and at individual genomic loci. And finally, I have examined what effect, if any, the active component of cannabis, which is an established environmental risk factor for schizophrenia, has on the DNA methylome, to understand how environmental risk can cause disease. In summary, the work presented in this thesis represents the movement from large scale (epi)genetic analysis and statistics to functional lab validation. This thesis contains several methods for the functional validation of identified (epi)genetic risk loci and risk factors for schizophrenia in a cellular model. From this we can now begin to explore how these changes in genetics, epigenetics, and environmental risk factors biologically link to the development and progression of schizophrenia and other neuropsychiatric disorders.
Construction of a Nomogram to Predict the Progression Free Survival in Patients With Lung Cancer

Field: Medicine (Health Sciences)

Abstract

PURPOSE For a personalized cancer prognosis, a nomogram is a practical and helpful tool. In addition to creating a clinical nomogram to forecast progression free survival (PFS) for patients with various histological types, clinical stages, and treatment regimens, our goals included assessing the prognostic variables of lung cancer (LC) patients. METHODS Clinical characteristics, peripheral blood parameters, and treatment records were collected from 1200 newly diagnosed LC patients in the Medical Oncology Department at Mohammed VI University Hospital in Marrakech between 2013 and 2021. Cox Proportional Hazards Regression Analysis was used to identify the independent prognostic factors. The nomogram we created and tested was used to predict the PFS of patients with LC. The Kaplan-Meier survival curves were drawn, stratified, and compared using the log rank test. RESULTS A total of 342 individuals met the inclusion criteria and were then included in the study. Prognostic factors for LC included gender, tabacco status, number of cures of the first-line chemotherapy, radiotherapy, and thrombocytopenia; these factors were combined to create the nomogram. The clinical prediction model performed satisfactorily in prognosis prediction, as evidenced by the calibration and receiver operating characteristics curves. In comparison to the clinical TNM staging method for a one-year prediction, the nomogram's area under the ROC curve (AUC) value for 6- and 12-month PFS rates was 0.8 and 0.83, respectively. CONCLUSION We developed and verified a unique nomogram that can offer personalised PFS predictions for Moroccan and African LC patients. The development of this tool is extremely important for clinical study design and decision-making.
Investigations of the metastable phase behavior of phosphatidylglycerol with divalent cations by calorimetry and manganese ion binding measurements

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigations of the metastable phase behavior of phosphatidylglycerol with divalent cations by calorimetry and manganese ion binding measurementsJoan M. Boggs and Godha RangarajCite this: Biochemistry 1983, 22, 23, 5425–5435Publication Date (Print):November 8, 1983Publication History Published online1 May 2002Published inissue 8 November 1983https://pubs.acs.org/doi/10.1021/bi00292a026https://doi.org/10.1021/bi00292a026research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tumor of undescended testicle in an infant

Field: Medicine (Health Sciences)

A TERATOMA in the undescended testis of an infant is of such rarity that a search of the American literature published during the past ten years fails to show a reported case. I have no knowledge of any other reports. The following case report is rendered for that reason and with the hope that it may be of interest to those dealing with patients of similar age and sex, for teratoma is another lesion to be considered in the differential diagnosis of an intra-abdominal mass in an infant. Teratomas are neoplasms arising from totipotential cells that produce many types of tissue. They are most frequently found in the gonads but occur at times in the neck and mediastinum. They may become malignant. One can postulate that the presence of a tumor in an undescended testis indicates that its size may have prevented descent of the embryonic organ. This migration takes
Prospective Study of Ultraviolet Radiation Exposure and Thyroid Cancer Risk in the United States

Field: Medicine (Health Sciences)

Abstract Background: Thyroid cancer incidence has tripled in the past three decades, yet relatively few risk factors have been identified. Some studies have suggested that ultraviolet radiation (UVR) may affect thyroid cancer risk. Methods: We conducted a prospective analysis of 44,039 participants in the United States Radiologic Technologists Study (153 thyroid cancer cases) from all 50 states. We examined the association between risk of thyroid cancer and exposure to UVR, estimated by ambient UVR, time outdoors, and a combined variable. Participants reported location of residence and time outdoors during five age periods starting in childhood. Ambient UVR was estimated by linking satellite-based UVR measurements to geocoded residences. We assessed the association of UVR by age and average lifetime UVR with thyroid cancer risk using Cox proportional hazards models, starting at the time of the baseline questionnaire (2003–2005) through 2012–2013. Results: Combined UVR from the latest age period (age 40+) was associated with a decreased risk of thyroid cancer (HR for 4th vs. 1st quartile = 0.56; 95% CI, 0.31–1.02, Ptrend = 0.04). This was limited to participants with benign thyroid disease and to those with darker complexions, although we found no evidence of effect modification. Thyroid cancer risk was unrelated to all metrics of UVR in earlier age periods and for average lifetime exposure. Conclusions: Recent UVR exposure was associated with a decreased risk of thyroid cancer. This association appeared to be modified by benign thyroid disease and skin complexion. Impact: UVR exposure may be associated with a decreased risk of thyroid cancer. Cancer Epidemiol Biomarkers Prev; 26(5); 684–91. ©2016 AACR.
Unit commitment in electrical power system-a literature review

Field: Energy (Physical Sciences)

This paper brings out the studies of generation scheduling problem in an electrical power system. This paper presents some general reviews of research and developments in the field of unit commitment based on published articles and web-sites. Here, it is set about to perform a comprehensive survey of research work made in the domain of Unit Commitment using various techniques. This may be a helpful tool for the researchers, scientists or investigators working in the area of unit commitment.