jimnoneill/paper-to-field-training huggingface dataset:
Comparison of the antimicrobial activities of roselle calyx extracts and chemical sanitizers directly onto contaminated cucumbers

Field: Agricultural and Biological Sciences (Life Sciences)

Cucumbers are associated with foodborne disease caused by Salmonella. Fruits and vegetables in restaurants and homes in Mexico are disinfected using sodium hypochlorite and colloidal silver solution. However, a number of studies show that chemical agents used to eliminate pathogenic bacteria have a limited antimicrobial effect. Previous studies show that roselle calyx extracts have antimicrobial effects. Therefore, the present study examined the attachment of 14 foodborne bacteria to whole cucumber in the presence of Hibiscus sabdariffa calyx extracts, sodium hypochlorite, acetic acid, and colloidal silver. Cucumbers were inoculated with 14 bacteria: Listeria monocytogenes, Shigella flexneri, Staphylococcus aureus, Salmonella Typhimurium, Salmonella Typhi, Salmonella Montevideo, Salmonella Choleraesuis, Escherichia coli O157:H7, non-O157:H7-Shiga toxin-producing E. coli, enteropathogenic E. coli, enterotoxigenic E. coli, enteroinvasive E. coli, enteroaggregative E. coli, and Vibrio cholerae O1. The antibacterial effect of four roselle calyx extracts (in water, methanol, acetone, and ethyl acetate) and some chemical sanitisers including sodium hypochlorite, colloidal silver, and acetic acid were then examined. All foodborne bacteria successfully attached to cucumber. The acetonic and methanolic roselle extracts caused a greater reduction (up to 4 log cfu in some cases) in the concentration of all foodborne bacteria than sodium hypochlorite, colloidal silver, and acetic acid. Thus, roselle calyx extracts may be a potentially useful disinfectant for cucumbers in the field, in processing plants, and in restaurants and homes.
Hooke's memorandum on the development of orbital dynamics

Field: Physics and Astronomy (Physical Sciences)

I discuss a memorandum entitled " A True state of the Case and Controversy between Sir Isaak Newton and Dr. Robert Hooke as the Priority of that Noble Hypothesis of motion of ye Planets about ye Sun as their Centers", where Hooke summarizes his life long contributions to the development of the physics of orbital motion and the universal theory of gravitation
Solving Systems of Equations in Supernilpotent Algebras

Field: Mathematics (Physical Sciences)

Recently, M. Kompatscher proved that for each finite supernilpotent algebra A in a congruence modular variety, there is a polynomial time algorithm to solve polynomial equations over this algebra. Let mu be the maximal arity of the fundamental operations of A, and let d := |A|^{log_2 mu + log_2 |A| + 1}. Applying a method that G. Károlyi and C. Szabó had used to solve equations over finite nilpotent rings, we show that for A, there is c in N such that a solution of every system of s equations in n variables can be found by testing at most c n^{sd} (instead of all |A|^n possible) assignments to the variables. This also yields new information on some circuit satisfiability problems.
Evaluating the Effects of Geographic Contexts on Individual Accessibility: A Multilevel Approach1

Field: Social Sciences (Social Sciences)

Centrality within a city and neighborhood characteristics have often been used as indicators of access to employment and services in statements about urban form and accessibility, but there are reasons to question the appropriateness of doing so. This paper evaluates the importance of geographic context within the urban environment (both location within cities as well as neighborhoods characteristics) for individuals in Portland, Oregon. Because conventional accessibility measures cannot incorporate individual characteristics, space-time individual accessibility measures were used with multilevel modeling to isolate the effects of individual level variations from that of geographical context. The results show that the influence of context on individual accessibility is weak, as accessibility tends to reflect individual and household characteristics rather than the local urban environment. Accessibility cannot be determined from location within cities, or from land uses around an individual's home, implying that the use of urban design to influence accessibility is inappropriate.
27th Annual CSP Workshops on "Recent Developments in Computer Simulation Studies in Condensed Matter Physics", CSP 2014 Open boundary conditions in stochastic transport processes with pair-factorized steady states

Field: Physics and Astronomy (Physical Sciences)

Using numerical methods we discuss the effects of open boundary conditions on condensation phenomena in the zero-range process (ZRP) and transport processes with pair-factorized steady states (PFSS), an extended model of the ZRP with nearest-neighbor interaction. For the zero-range process we compare to analytical results in the literature with respect to criticality and condensation. For the extended model we find a similar phase structure, but observe supercritical phases with droplet formation for strong boundary drives. c
Partial purification of ribose 1-phosphate dependent “ADP forming” activity in rat liver

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Conference Article| May 01 1993 Partial purification of ribose 1-phosphate dependent “ADP forming” activity in rat liver R. LEONCINI; R. LEONCINI 1Institute of Biochemistry and Enzymology - University - Pian dei Mantellini 44 - Siena (Italy) Search for other works by this author on: This Site PubMed Google Scholar D. VANNONI; D. VANNONI 1Institute of Biochemistry and Enzymology - University - Pian dei Mantellini 44 - Siena (Italy) Search for other works by this author on: This Site PubMed Google Scholar R. GUERRANTI; R. GUERRANTI 1Institute of Biochemistry and Enzymology - University - Pian dei Mantellini 44 - Siena (Italy) Search for other works by this author on: This Site PubMed Google Scholar S. RIGHI; S. RIGHI 1Institute of Biochemistry and Enzymology - University - Pian dei Mantellini 44 - Siena (Italy) Search for other works by this author on: This Site PubMed Google Scholar R. PAGANI; R. PAGANI 1Institute of Biochemistry and Enzymology - University - Pian dei Mantellini 44 - Siena (Italy) Search for other works by this author on: This Site PubMed Google Scholar E. MARINELLO E. MARINELLO 1Institute of Biochemistry and Enzymology - University - Pian dei Mantellini 44 - Siena (Italy) Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1993) 21 (2): 188S. https://doi.org/10.1042/bst021188s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation R. LEONCINI, D. VANNONI, R. GUERRANTI, S. RIGHI, R. PAGANI, E. MARINELLO; Partial purification of ribose 1-phosphate dependent “ADP forming” activity in rat liver. Biochem Soc Trans 1 May 1993; 21 (2): 188S. doi: https://doi.org/10.1042/bst021188s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1993 Biochemical Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
An analysis of crossover's effect in genetic algorithms

Field: Computer Science (Physical Sciences)

The crossover operation is characteristic of genetic algorithms (GAs). This paper analyzes the crossover effect in GAs. We start with two bits, that is the minimum chromosome length to crossover. We compare one operator GAs, using only selection, and two operators GAs by selection and crossover with respect to the expected quality and speed of the convergence. First, we analyse the case of two individuals, that is the minimum population size, by a Markov chain. We show the boundary in the fitness assignment cube where crossover improves the absorption probability to the optimum. We also show that crossover always speeds up convergence. Second, we analyse the larger population case by numerically solving the difference equations. We show a boundary where the crossover speeds up convergence. Normal medium sized GAs can be positioned between these two extremes.< >
Maximizing off-grid solar photovoltaic system efficiency through cutting-edge performance optimization technique for incremental conductance algorithm

Field: Energy (Physical Sciences)

The maximum power point tracking (MPPT) algorithms are required to deliver the optimal energy from solar photovoltaic cells/array (PV) under numerous weather conditions. Therefore, MPPT circuits driven by defined rules called algorithms are designed. These algorithms range from simple to complex in design and implementation and are selected based on the scenarios of the surroundings. However, the incremental conductance (InC) MPPT algorithm is one of the market's most simple, easy to implement, and demanding algorithms. The drawback associated with the InC algorithm is its tracking speed. To overcome this weakness various researchers have made multiple improvements. Although the performance became better but was not satisfied. Further, the improvements introduce steady-state oscillations of the operating point around the MPP. So, the user needs to pick and choose based on demand. Keeping the target in focus, we have introduced a couple of modifications in the structure of INC. that remain fruitful. The proposed structure named the augmented InC algorithm has shown marvelous improvement in tracking speed and steady-state oscillations. The results have been compared with the conventional InC algorithm, where the proposed augmented InC algorithm has outperformed the conventional InC algorithm in tracking speed and steady-state oscillations. We have used the MATLAB script to code the conventional InC algorithm and proposed augmented InC algorithms based on their designed flowchart. Both algorithms have been applied to the standalone solar photovoltaic system composed of a solar photovoltaic array, DC/DC boost converter, illumination and temperature inputs, MPPT algorithm, and a DC load. The model is designed in Simulink/MATLAB.
Power in the Firm and Managerial Career Concerns

Field: Business, Management and Accounting (Social Sciences)

More powerful managers make more important decisions. Therefore, firm performance is more informative about the abilities of such managers, who, realizing that they are more visible, are more eager to improve performance. If this reputation effect exists, how should firms allocate power? I analyze the optimal allocation of power and derive implications for several issues that often arise in management practice: the choice of departmentation criteria, the importance given to seniority, and the width of job definitions. Finally, I show that the model is consistent with the empirical evidence on managerial succession. Copyright (c) 2003 Massachusetts Institute of Technology.
Isolation of Aaptic Acid from the Marine Sponge Aaptos lobata and Inhibitory Effect of Aaptamines on RANKL-Induced Formation of Multinuclear Osteoclasts

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

A new aaptamine congener, aaptic acid (1), was isolated from the marine sponge Aaptos lobata collected in Indonesia, together with aaptamine (2), demethyl(oxy)aaptamine (3), and isoaaptamine (4).The chemical structure of 1 was assigned on the basis of NMR data.The isolated compounds were tested for inhibitory activities against osteoclastogenesis in RAW264 cells.At 5 μM concentration, 2-4 inhibited RANKL-induced multinuclear osteoclast formation by 25%, 54%, and 17%, respectively.In contrast, 1 did not inhibit osteoclastogenesis even at 50 μM.Aaptamine (2) is a marine alkaloid bearing a benzo[de][1,6]-naphthyridine scaffold and was isolated from the sponge Aaptos aaptos collected at Manza beach in Okinawa in 1982. 1 Since its isolation, more than thirty congeners have been isolated from sponges of the genera Aaptos, 2 Xestospongia, 3 Suberites, 4Hymeniacidon, 5 and Luffariella. 6,7Interestingly, the congeners have been reported to show broad spectra of biological activities, such as cytotoxic, 2,3,8 antimicrobial, 2,3 antiviral, 9 antifouling, 10 antioxidant, 11 and enzymatic inhibitory activities. 12The cytotoxic effect of 2 was well investigated and found to activate the cyclin dependent kinase inhibitor p21, which leads to inhibition of cell cycle progression and induction of apoptosis. 13Further, proteome analysis indicated that 2 exhibited cytotoxic activity by targeting myc and p53 and promoted hypusination of eukaryotic initiation factor 5A-1 (eIF5A). 14In our continuing search
The executive on the battlefield: government amendments and cartel theory in the Chilean Congress

Field: Social Sciences (Social Sciences)

This article argues that cartelised coordination inside Chilean congressional committees is important for understanding the success rates of presidential initiatives. By way of an analysis of the amendment process undertaken both in the Chamber and Senate committees in the Chilean Congress during 2006–10, the authors review the approval patterns of legislative amendments. The analysis suggests two chief findings: coordination between government parties and the executive is crucial for the success of amendment; and the opposition's success in generating legal transformations depends on the construction of inter-coalition alliances. It is hoped that the perspective offered here will contribute to the current literature on cartel party theory in Latin America.
Food safety plans: three problems to address when analysing microbiological hazards

Field: Agricultural and Biological Sciences (Life Sciences)

Food safety programs set out how safe food is produced. The primary objective of designing food safety plans is to ensure food is safe and suitable for human consumption. However if the design of the food safety plan is affected by lack of knowledge of the biological, chemical and physical (BCP) hazards of the food production process, then food safety may not be assured. This paper focuses on three problems when analysing the microbiological hazards that can affect the quality of the food safety plan and which may result in unsafe food and a false sense of security for the food manufacturer.
Diversity and Morphology of Members of the Phylum “ Synergistetes ” in Periodontal Health and Disease

Field: Medicine (Health Sciences)

ABSTRACT Members of the phylum “ Synergistetes ” have frequently been detected in the human oral cavity at sites of dental disease, but they have rarely been detected in studies of oral health. Only two oral “ Synergistetes ” taxa are cultivable. The aims of this study were to investigate the diversity of “ Synergistetes ” in the oral cavity, to establish whether “ Synergistetes ” taxa are more strongly associated with periodontitis than with oral health, and to visualize unculturable “ Synergistetes ” in situ. Sixty samples (saliva, dental plaque, and mucosal swabs) were collected from five subjects with periodontitis and five periodontally healthy controls. Using phylum-specific 16S rRNA gene primers, “ Synergistetes ” were identified by PCR, cloning, and sequencing of 48 clones per PCR-positive sample. Subgingival plaque samples were labeled with probes targeting rRNA of unculturable oral “ Synergistetes ” using fluorescent in situ hybridization (FISH). Analysis of 1,664 clones revealed 12 “ Synergistetes ” operational taxonomic units (OTUs) at the 99% sequence identity level, 5 of which were novel. “ Synergistetes ” OTU 4.2 was found in significantly more subjects with periodontitis than controls ( P = 0.048) and was more abundant in subgingival plaque at diseased sites than at healthy sites in subjects with periodontitis ( P = 0.019) or controls ( P = 0.019). FISH analysis revealed that unculturable oral “ Synergistetes ” cells were large curved bacilli. The human oral cavity harbors a diverse population of “ Synergistetes. ” “ Synergistetes ” OTU 4.2 is associated with periodontitis and may have a pathogenic role.
Influence of Ecotourism Experience on Tourists' Environmentally Responsible Behavior: A Case Study of Luya Mountain Scenic Area

Field: Social Sciences (Social Sciences)

This paper explores the pathway toward harmonious coexistence between humanity and nature through the lens of ecotourism, delving into its impact on tourists' cognition of the natural environment, cultivation of emotional connections, and its pivotal role in shaping environmentally responsible behavior. At the Luya Mountain Scenic Area, a case study was conducted in July 2021, collecting 632 valid tourist questionnaires to investigate the nexus among “ecotourism experience”, “emotional experience”, and “environmental responsibility behavior” using structural equation modeling. Moreover, the relationship between tourism and daily environmental behavior was scrutinized with canonical correlation analysis. The findings unveil several substantial revelations: (1) Engagement experience significantly and positively influences tourists' inclination toward responsible behavior. (2) Emotional experience mediates the relationship between educational, engagement, and escapism experiences and the inclination to act responsibly. (3) The utilization of digital information technologies positively moderates the conversion of emotional experience into a willingness to behave responsibly. (4) Ecotourism responsibility is linked to daily behavior, and cognitive and emotional experiences foster long-term environmental protection. This study provides a pioneering approach to enhancing tourism offerings within the scenic area and nurturing a sustainable human-environment relationship.
Binding Specificity of a Human Leucocyte Carbohydrate-Binding Protein

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The binding site specificity of a carbohydrate-binding protein (CBP) synthesized in vitro by normal human peripheral leucocytes was analyzed by affinity chromatography on asialofetuin-Sepharose. Radiolabelled cell extracts were applied to affinity columns. After washing with buffer, the columns were eluted with varying concentrations of different saccharides. The results show that lactose and thiodigalactoside were two of the best inhibitors of CBP binding to asialofetuin. The weakest inhibitors were methyl-beta-D-galactoside and raffinose. Binding of galactose to the CBP was enhanced by the presence of p-NO2-phenyl aglycones. Saccharides unrelated to the D-galactosyl residue failed to inhibit the CBP. Heat-inactivated plasma appeared to have little, if any, binding inhibitors. Binding of CBP to asialofetuin appeared to be inhibited by amine-containing compounds.
Design and Evaluation of a Spanish Language Therapy Support System

Field: Health Professions (Health Sciences)

Specific Language Impairment (SLI) is a language disorder that delays progress in mastering speech-language skills, and typically occurs in childhood. Most speech-language pathologists commonly use paper-based instruments to diagnose and treat this problem. This article describes the design, implementation, and evaluation of SATEL, an ontology-based system used both in diagnosing this condition and as part of speech therapy for children with SLI. With the help of a Kinect sensor, SATEL is able to recognize and classify pronounced words. The proposed system was designed and evaluated by a team of four speech-language pathologists and 26 children diagnosed with SLI. Results showed an accuracy rate of 94.42% and 97.75% in recognizing syllables and words correctly and incorrectly pronounced in the diagnostic and treatment modules, respectively.
Pembrolizumab (MK-3475) for recurrent or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma: Multicohort phase II KEYNOTE-059 study.

Field: Medicine (Health Sciences)

TPS184 Background: Pembrolizumab (pembro) is a humanized monoclonal antibody that targets the PD-1 receptor and prevents it from interacting with its ligands, PD-L1 and PD-L2. In the phase I KEYNOTE-012 trial, pembro showed an acceptable safety profile and promising antitumor activity in patients (pts) with PD-L1 + metastatic gastric cancer. The multicohort, phase II KEYNOTE-059 (NCT02335411) trial was designed to further evaluate pembro as monotherapy or in combination with 5-fluorouracil (5-FU) and cisplatin in pts with advanced gastric cancer. Methods: Patients ≥ 18 y who have relapsed or metastatic gastric or GEJ adenocarcinoma, ECOG PS 0-1, no active autoimmune disease or brain metastases, and no prior chemotherapy within 2 wk of the first dose of pembro are eligible. PD-L1 expression status will be determined by IHC using the 22C3 antibody (Merck). In cohort 1 (C1), up to 180 pts with any PD-L1 status whose disease progressed on ≥ 2 prior chemotherapy regimens, including a fluoropyrimidine and platinum doublet and, if HER2 + , trastuzumab, will receive pembro 200 mg Q3W. In cohort 2 (C2), ~12 Asian and ~6 non-Asian, treatment-naive, HER2 – pts of any PD-L1 status will receive pembro 200 mg Q3W + infusional 5-FU or capecitabine and 6 cycles of cisplatin. In cohort 3 (C3), ~25 treatment-naive pts with HER2 – /PD-L1 + tumors will receive pembro 200 mg Q3W. Treatment may continue for up to 24 mo or until progression, intolerable toxicity, or investigator decision. Response will be assessed at wk 9 and every 6 wk thereafter per RECIST v1.1 and RECIST v1.1 adapted for immunotherapy response patterns. Treatment may be discontinued for eligible pts who have a CR. Eligible pts may continue treatment beyond initial RECIST-defined progression. AEs will be collected throughout the study and for 30 d thereafter (90 d for serious AEs) and graded per NCI CTCAE v4.0. The primary efficacy end point for C1 and C3 is ORR per RECIST v1.1 by central review; the primary end point for C2 is safety and tolerability of the combination. Secondary end points include PFS, OS, DCR, and duration of response. Enrollment in KEYNOTE-059 is ongoing and will continue until up to 223 pts are enrolled across all cohorts. Clinical trial information: NCT02335411.
Physical Activity and Exercise for Men with Late Onset Hypogonadism

Field: Medicine (Health Sciences)

=A bstract = Late onset hypogonadism (LOH, also referred to as age-associated testosterone deficiency syndrome, TDS) is a clinical and biochemical syndrome associated with advancing age and characterized by symptoms and a deficiency in serum testosterone levels. It may result in a significantly reduced quality of life and adversely affect the function of multiple organ systems. Although the treatment of LOH is primarily based on hormone replacement, other treatment modalities (medical or non-medical treatment) can also be considered for various accompanying symptoms. The efficacy of exercise in the treatment of LOH has already been evaluated in several studies, and many of them show beneficial effects for some specific symptoms and diseases. This study was designed to evaluate the relationship between exercise and plasma testosterone levels, and the potential beneficial effects of exercise for each specific symptom of LOH, and finally to consider the appropriate exercise treatment for LOH.
Neurology of John Hunter's Last Illness

Field: Neuroscience (Life Sciences)

John Hunter's angina has often been described, but less attention has been paid to the neurological symptoms of his last illness.These were unusual enough to be intrinsically interesting, and they derive an added interest from the fact that the account of them given by Home (1794), John Hunter's brother-in-law, was clearly de- rived from Hunter himself and includes his own attempt to interpret them.