jimnoneill/paper-to-field-training huggingface dataset:
Stent-Graft Repair of a Mycotic Left Subclavian Artery Pseudoaneurysm

Field: Medicine (Health Sciences)

Purpose: To report successful stent-graft treatment of a mycotic pseudoaneurysm of the left subclavian artery in an immunosuppressed patient. Case Report: A 17-year-old immunosuppressed woman undergoing treatment for recurrent leukemia developed persistent fever and 2 episodes of hemoptysis. A contrast-enhanced computed tomographic (CT) scan demonstrated a saccular aneurysm of the left subclavian artery, which was considered to be a mycotic aneurysm caused by erosive fungal infection from the lung. The pseudoaneurysm was treated with a homemade stent-graft consisting of a nitinol stent and a polyester fabric. A type II endoleak present at the end of the procedure appeared to have sealed spontaneously on the CT scan at 3 days. No neurological deficit or ischemic symptoms of the left arm were noted during the follow-up, which lasted until the patient died 11 months later after rejecting a second bone marrow transplant. Conclusions: Endovascular repair may be an alternative to open surgery for the management of mycotic aneurysms of the subclavian artery.
Abstract 3471: Mutual regulation of MDM4 and TOP2A in cancer cell proliferation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract MDM4 and topoisomerase IIα (TOP2A) are important cancer-related factors. MDM4 acts as an oncoprotein promoting cancer progression by inhibiting tumor suppressor p53. As a DNA replication- and cell division-regulating enzyme, TOP2A is the main target of many anticancer therapy regimens, even though the exact role of TOP2A in cancer remains elusive. Herein we report that MDM4 and TOP2A bind to each other and are mutually upregulated at the post-translational level, leading to enhanced TOP2A catalytic activity, inhibition of p53, and increased tumor-cell proliferation. We demonstrate that the C-terminal region (CTR) of TOP2A binds to a unique sequence (residues 188-238) of MDM4, which contains an auto-inhibitory segment regulating MDM4-p53 interaction. TOP2A binding in turn activates MDM4 for p53 binding, resulting in enhanced inhibition of p53 and cancer cell proliferation. Conversely, binding of the MDM4 sequence to the CTR of TOP2A upregulates TOP2A protein expression. This in turn interferes with TOP2A DNA-decatenating activity. These results reveal novel functions of MDM4 and TOP2A as well as their interactions in oncogenesis, suggesting that inhibition of the MDM4-TOP2A interaction may represent a novel strategy in specifically and simultaneously targeting TOP2A and MDM4 for cancer treatment. Citation Format: Tao Liu, Hailong Zhang, Sha Yi, Lubing Gu, Muxiang Zhou. Mutual regulation of MDM4 and TOP2A in cancer cell proliferation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3471.
Changes in Household Structure and Consumption Patterns among Households with HIV-positive members in Uttar Dinajpur district, West Bengal

Field: Social Sciences (Social Sciences)

The HIV/AIDS epidemic threatens the social shape of the most affected international locations. Of all the units suffering from the HIV/AIDS epidemic, people, households, and families are the most affected. Evidence shows that the AIDS epidemic has severe consequences on households. In addition to the social and psychological outcomes, HIV contamination poses a serious hazard to the household economy. The HIV/AIDS epidemic can result in an exchange within the composition of families, with the gradual disappearance of parental technology and kids cared for with the aid of grandparents and other households some cases, older kids may additionally act as surrogate dads and moms for his or her younger siblings, main to an increase in single-era households headed by older kids. The composition of many families is complex and changes through the years. It is even greater complex when the head of the household, generally a person, will become inflamed with HIV, will become ill and in lots of cases dies. This also results in moving dynamics inside households. There are some ways in which HIV and AIDS can have an effect on the extent and sample of household consumption and in the end, have a negative impact on character sectors. The analysis suggests that families with HIV participants spend a big part of their monthly intake expenditure on medicines. Nearly 12.53 percent of the whole consumption expenditure of families with HIV is dedicated to scientific fees at the submit-symptomatic level which is a good deal better than the expenditure on education. This confirms the general idea within the literature that HIV and AIDS can affect kids’ schooling. As nutritious and balanced meals are vital to ensure longer and healthier lives for human beings living with HIV/AIDS (PLHA), it's far critical to decide whether those families spend less on food, or not, even in absolute phrases, inside the post-symptomatic stage. The policy reaction has to encompass the proper stability among targeted medical health insurance interventions and social security structures to protect households with HIV+ individuals from impoverishment because of HIV-associated illnesses.
Raw data for "Cadmium Enhances Salmonella Thphimurium-Induced Intestinal Barrier Dysfunction via ERK/AKT-Gli1-Snail Signaling"

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

This dataset contains the raw and supplementary data supporting the findings reported in the manuscript entitled "Cadmium Enhances Salmonella Typhimurium-Induced Intestinal Barrier Dysfunction via ERK/AKT-Gli1-Snail Signaling".Five Western blot images and a table containing Primers used for real-time RT-PCR analysis of the EMT-related genes are included in the set.These data allow independent validation of the reported results.
Variant Human T-cell Lymphotropic Virus Type 1c and Adult T-cell Leukemia, Australia

Field: Medicine (Health Sciences)

Human T-cell lymphotropic virus type 1 is endemic to central Australia among Indigenous Australians. However, virologic and clinical aspects of infection remain poorly understood. No attempt has been made to control transmission to indigenous children. We report 3 fatal cases of adult T-cell leukemia/lymphoma caused by human T-cell lymphotropic virus type 1 Australo-Melanesian subtype c.
H E R M E N E U T I K A Sebuah Teori Lama Mengenai Interpretasi Teks yang Tampak Baru

Field: Arts and Humanities (Social Sciences)

Hermeneutics as an object of study is a means of understanding the ”actual” as old ashuman beings age on this earth. Hermeneutics is very important in the process of humaninteraction, so the study was conducted to study the hermeneutics in his position as a scienceof interpretation that can be studied in ontological, epistemological, and axiological. As ascience, hermeneutics emerged as a dominant movement in European Protestant theologywhich states that hermeneutics is a focal point of the current theological issues.Associated with his position as a science, the study was conducted to determinehermeneutics in the concept of etymology and terminology, knowing on historically with thefigures who pioneered the science of it, his position as a theory of interpretationmultidisciplinary, as well as the position and function as a historiographical approach throughphilological approach.Keywords: hermeneutics, the theory of interpretation, and text.
Improving yield and reliability of FIB modifications using electrical testing

Field: Engineering (Physical Sciences)

Focused Ion Beam technology has two main areas of application for ICs: modification and preparation for technological analysis. The most solicited area is modification. This involves physically modifying a circuit by cutting lines and creating new ones in order to change the electrical function of the circuit. IC planar technologies have an increasing number of metal interconnections making FIB modifications more complex and decreasing their changes of success. The yield of FIB operations on ICs reflects a downward trend that imposes a greater number of circuits to be modified in order to successfully correct a small number of them. This requires extended duration, which is not compatible with production line turn around times. To respond to this problem, two solutions can be defined: either, reducing the duration of each FIB operation or increasing the success rate of FIB modifications. Since reducing the time depends mainly on FIB operator experience, insuring a higher success rate represents a more crucial aspect as both experienced and novice operators could benefit from this improvement. In order to insure successful modifications, it is necessary to control each step of a FIB operation. To do this, we have developed a new method using in situ electrical testing which has a direct impact on the yield of FIB modifications. We will present this innovative development through a real case study of a CMOS ASIC for high-speed communications. Monitoring the electrical behavior at each step in a FIB operation makes it possible to reduce the number of circuits to be modified and consequently reduces system costs thanks to better yield control. Knowing the internal electrical behavior also gives us indications about the impact on reliability of FIB modified circuits. Finally, this approach can be applied to failure analysis and FIB operations on flip chip circuits.
Proposal of electrically reversal magnetic pole type variable magnetic flux PM motor

Field: Engineering (Physical Sciences)

This paper describes a variable magnetic flux PM motor in which space harmonic power is utilized for the magnetic flux weakening, automatically. The stator has a toroidally-concentrated winding structure, and the torque generation surfaces are composed of three air-gaps which are single radial-gap and double axial-gaps. The radial-gap rotor is a consist-magnetized PM rotor and the axial-gap rotors are self-excited wound-field rotor. The axial-gap rotor can retrieve a space harmonic power, which is inevitably generated by a concentrated winding structure, for magnetomotive force. A mechanical design of the prototype is revealed, and the operation principle of the automated-magnetic flux weakening is clarified through the FE-analysis. In addition, actual prototype machine is introduced. Consequently, the effect of automated-armature line voltage decrease is investigated with respect to rotation speed increase.
Design Characteristic of Orthopedic Shoe Product for Ameliorating Disorder of Foot Disease

Field: Health Professions (Health Sciences)

산업화와 인구 고령화에 의한 후천적 장애 인구는 꾸준히 증가하고 있으며, 이는 누구나 장애로부터 안심 할 수 없음을 의미한다. 특히 고령일수록 그 가능성이 더욱 높아지고 있다는 점은 인구 고령화에 대한 사회적 문제가 대두되고 있는 현시점에서 더욱 관심 있게 다루어야 할 사항으로 여겨진다. 이에 장애인에 대한 사회 적 인식과 국가적 제도는 물론 디자인 분야에서도 장애인과 비장애인 모두를 포용하는 변화의 움직임이 시 도되고 있으나, 정형 신발의 경우 제작 과정의 특수성으로 인해 제약이 따르고 있다. 따라서 본 연구는 정형 신발 제품의 디자인 요소와 특성을 분석하고 최적화된 정형 신발 디자인을 구현함에 목적이 있다. 이러한 정형 신발의 구조와 이론적 연구를 위해 최근 25년간 출간된 130여 편의 지체장애인과 발, 신발, 인솔에 관한 논문을 고찰하였고, 관련 기관의 장애인 실태조사 및 통계자료를 근거로 국내 현황을 파악하였다. 또한 국내 외 60여 개 브랜드의 성인 남녀 정형 신발 제품 550개를 대상으로 디자인 요소를 파악하고 이를 토대로 특성 을 도출하였다. 연구결과는 다음과 같다. 첫째, 정형 신발은 특수한 발에 대한 보편적 측정의 어려움으로 인 해 타 분야와 달리, 유니버설 디자인의 개념 적용이 어렵다는 점을 이해할 수 있었다. 둘째, 디자인 요소 내 각 항목들은 장애인들의 물리적, 심리적 요인이 작용함에 따라 몹시 편중된 선호 양상을 보이고 있음을 알 수 있었다. 셋째, 인간공학적으로 설계된 디자인은 용이한 구조로 제작되어 손쉽게 사용 가능하며, 일반 신발 보다 각 부분별 기능이 더 크게 작용함으로써 장애인들이 자립적으로 행동할 수 있도록 기여함을 알 수 있었 다. 넷째, 심리적 요인으로 인해 장애인들의 미적 기준은 비장애인들과 다소 상이함을 알 수 있었다. 본 연구 결과를 토대로 족부질환 장애인들의 욕구가 충족될 정형 신발 제품이 구현되길 기대하며, 궁극적으로 장애인 들의 보행 기능 개선과 이동성 증대에 따른 원활한 사회참여, 그로 인한 삶의 개선에 기여하는 데 의의가 있다.
The Ambiguous Construction of Nondominant Masculinity: Configuring the “New” Man through Narratives of Choice, Involved Fatherhood, and Gender Equality

Field: Social Sciences (Social Sciences)

This article explores the development of gender equality-oriented (heterosexual) masculinity discussing the challenges of constructing nondominant masculine identities in the context of the Danish welfare state. Combining narrative methods with the theoretical framework of masculinity as cultural repertoire, the article offers a qualitative study examining how three Danish men construct (gender) identity in relation to being the partners of career-oriented and high-achieving women. Analyzing the men’s narrative negotiations of power, gender, and self, the article identifies three central narratives produced by the men to render themselves and their family arrangements intelligible and desirable. Considering how the narratives of (1) choice, (2) involved fatherhood, and (3) gender equality work as strategies to negotiate and reconstruct the meaning of compliance and autonomy, I delineate and discuss how traditional notions of what it means to be a man are simultaneously preserved and destabilized. Thus, the article demonstrates that, while nurturing practices and the loss of traditional male breadwinner authority can be positively reconstituted within the Nordic ideals of intensive parenting and gender equality, a fear of male subordination still seems to affect the construction of masculine selves even among gender equality–oriented “new” men.
Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The TET family of dioxygenases (TET1/2/3) can convert 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and has been shown to be involved in active and passive DNA demethylation. Here, we demonstrate that altering TET dioxygenase levels within physiological range can affect DNA methylation dynamics of HEK293 cells. Overexpression of TET1 increased global 5hmC levels and was accompanied by mild DNA demethylation of promoters, gene bodies and CpG islands. Conversely, the simultaneous knockdown of TET1, TET2, and TET3 led to decreased global 5hmC levels and mild DNA hypermethylation of above-mentioned regions. The methylation changes observed in the overexpression and knockdown studies were mostly non-reciprocal and occurred with different preference depending on endogenous methylation and gene expression levels. Single-nucleotide 5hmC profiling performed on a genome-wide scale revealed that TET1 overexpression induced 5mC oxidation without a distribution bias among genetic elements and structures. Detailed analysis showed that this oxidation was related to endogenous 5hmC levels. In addition, our results support the notion that the effects of TET1 overexpression on gene expression are generally unrelated to its catalytic activity.
Prospects for applications of electron beams in processing of gas and oil hydrocarbons

Field: Energy (Physical Sciences)

Waste-free processing of oil and oil gases can be based on electron-beam technologies. Their major advantage is an opportunity of controlled manufacturing of a wide range of products with a higher utility value at moderate temperatures and pressures. The work considers certain key aspects of electron beam technologies applied for the chain cracking of heavy crude oil, for the synthesis of premium gasoline from oil gases, and also for the hydrogenation, alkylation, and isomerization of unsaturated oil products. Electronbeam processing of oil can be embodied via compact mobile modules which are applicable for direct usage at distant oil and gas fields. More cost-effective and reliable electron accelerators should be developed to realize the potential of electron-beam technologies.
Misuse and interlaboratory test reproducibility of API 20E system.

Field: Immunology and Microbiology (Life Sciences)

One hundred strains were referred to us for identification because they apparently could not be identified satisfactorily with the API 20E system (appareils et procédés d'identification). The inability to identify 31 strains was due primarily to failure to follow the manufacturer's instructions. Twenty six further strains were found to have been correctly identified by the sender's own API 20E results, so that only the remaining 43 strains definitely fell into the category for which our identification service was intended. Eighteen of the 43 strains not identified by the sender were identified by us using the API 20E system, and several possible reasons are given to explain the differences in these results. The remaining 25 strains either could not be identified by us on the API 20E system or, in the case of 13, they could not be identified by our conventional system and therefore no comparison could be made. The average interlaboratory probability of errors for the API 20E tests was 6.1%.
Waves and fun acoustics

Field: Physics and Astronomy (Physical Sciences)

The presenter shares some experience with teachings and demonstration on waves, vibrations, and sound from classroom visits at kindergarten lovel, after school elementry school science enrichment, high school AP physics, to required graduate course in Acoustic and Electromagetic waves. Topics includestanding waves and lasagna, vibrating strings, coupled oscillators, parametric excitation, boundary conditions, effects of gravity, phonographs, and the Shive wave machine.
Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

This study provides data about anticancer properties of bee venom and its dominant compound, melittin on colorectal carcinoma cells (HCT-116 and SW-480) in regard to their proapoptotic activity and expression of genes involved in biotransformation process. Based on results, they are strong cytotoxins, where the melittin showed also selectivity against cancer cells compared to normal, HaCat. They induce proapoptotic activity by affecting apoptosis signaling molecules (Fas receptors, caspase 9, and members of Bcl-2 family of proteins) and mainly suppress expression of genes involved in their biotransformation, suggesting their ability to develop the resistance of colorectal cancer cells.
Electrocardiographically study of protective effect of Eruca Sativa M. versus doxorubicin induced cardiotoxicity in rabbits

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Cardiotoxicity is defined as drug-induced damage to the heart muscle, which can result in cardiac failure or cardiac arrest. Cardiotoxicity is a common side effect of traditional anticancer drugs such as doxorubicin, taxanes, 5-fluorouracil, and cyclophosphamide, as well as newer agents such as biological antibodies such as Nivo. Cardiotoxicity is also caused by the long-term use of neurologic/psychiatric medications. This study was designed to determine the effect of eruca sativa mill (Gergeer) leaves extract on cardiotoxicity induced by doxorubicin in rabbits. The thirty-five rabbits used in this study were obtained from a local rabbit breeder. Animals ranged between 1-1.3 years old, and their weight was approximately 1-2kg without specifying gender. experiment: Thirty-five adult rabbits (n=35) will be randomly divided into four groups (7 rabbits/each group) first group: seven rabbits will receive distal water (D.W) orally (-ve control), Second group: fourteen rabbits divided into two subgroup equally administrated with doxorubicin 4 mg/kg B.W (I.P) between day to day for 14 days to induce cardiotoxicity (the first subgroup leave two weeks then killed, while the second subgroup leaves to 28 days without treatment),
C-sequ Life cycle assessment guidelines for calculating carbon sequestration in cattle production systems

Field: Environmental Science (Physical Sciences)

The concept of carbon sequestration is acknowledged as a potential way for agriculture to not just emit carbon dioxide, but store it, removing it from the atmosphere. Up until now there has been no consensus on an appropriate LCA-based approach for application in cattle production systems to quantify carbon removals. The focus has always been on emissions only. As the cattle sector works towards net zero ambitions, an appropriate science-based approach is required to not only account for emissions but also quantity carbon removal as part of the GHG footprint reporting.
Testing the gravitational instability hypothesis?

Field: Physics and Astronomy (Physical Sciences)

We challenge a widely accepted assumption of observational cosmology: that successful reconstruction of observed galaxy density fields from measured galaxy velocity fields (or vice versa), using the methods of gravitational instability theory, implies that the observed large-scale structures and large-scale flows were produced by the action of gravity. This assumption is false, in that there exist non-gravitational theories that pass the reconstruction tests and gravitational theories with certain forms of biased galaxy formation that fail them. Gravitational instability theory predicts specific correlations between large-scale velocity and mass density fields, but the same correlations arise in any model where (a) structures in the galaxy distribution grow from homogeneous initial conditions in a way that satisfies the continuity equation, and (b) the present-day velocity field is irrotational and proportional to the time-averaged velocity field. We demonstrate these assertions using analytical arguments and N-body simulations of gravitational and non-gravitational models. We also show examples of gravitational and non-gravitational models that {\it fail} reconstruction tests because galaxy formation is modulated (``biased'') in a way that violates the continuity equation. We discuss the relation between the value of $\Omega$ inferred from velocity-density comparisons and the true cosmological value.
Status and drivers of households’ food security status in climate-sensitive coastal areas of Bangladesh: A comparison between the exposed and interior coasts

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Farming in coastal areas has unique challenges as climate change threatens coastal people's livelihoods and food security. Therefore, household food security remains a major concern, especially in Bangladesh's climate-sensitive coastal districts. This study compared the food security status and identified the factors influencing households' food security in the exposed and interior coasts of Bangladesh. A total of 750 households (exposed coast: 375 and interior coast: 375) were surveyed from six coastal areas. The Food Consumption Score (FCS), descriptive statistics, and a set of econometric models were used to achieve the objectives. Around 20% of households in the exposed coast were in the borderline category of FCS. The FCS of the interior coast households was significantly higher than the exposed coast households. The analysis results revealed that a 1 USD increase in the price of rice per kg would decrease the likelihood of being in the food secure category by more than 40%. Households who engaged in homestead gardening had a 4.30% and 9.15% higher likelihood of being in the food secure category in the interior and exposed coasts, respectively. Access to credit increased the likelihood of being in the food secure category by 7.15% in the exposed coast area. Economic status-related factors, such as higher farm and non-farm incomes, also increased the likelihood of being food secure in both coastal areas. To improve the household-level food security in coastal areas, location-specific sustainable farming practices, non-farm employment opportunities, rice price stabilization, agricultural training, and capital availability are warranted.
Role of bronchial and bronchoalveolar lavage in chronic obstructive lung disease.

Field: Medicine (Health Sciences)

The authors review the role of bronchoalveolar and bronchial lavage in chronic obstructive lung disease patients. Only a few papers were published in the last ten years on this matter. In addition, data are incomplete and often conflicting, mainly because of the limited number of patients sampled and of non-standardized techniques of analysis. However, both bronchoalveolar and bronchial lavage are likely to be useful research tools to understand the pathophysiologic mechanisms underlying chronic obstructive lung disease.