jimnoneill/paper-to-field-training huggingface dataset:
Therapy workshop: Experience of the senses

Field: Health Professions (Health Sciences)

Introduction The psychoactive substances consumption modifies the users’ sense-perception. Objectives Discuss the therapeutic workshop as a stimulation strategy of the sense organs. Methodology The activities were developed at a Center of Psycho-Social Attention for alcohol and other drugs – CPSAad, located in north-eastern Brazil. The therapeutic workshop was divided into six sessions; being worked a sense organ in each meeting. Initially, the sessions were explained and they entered the room in silence. At first, vision and lastly, taste. The taste dynamic session was initiated by the pool where users experienced different flavours and made distinctions between them, including a food without flavour, experiencing feelings of pleasure and displeasure. This dynamic was finalized in the institute's kitchen with different ice cream flavours. The participants freely served themselves, being led to reflections on their choices of pleasure. The sixth session was constituted by listening about all Therapy Workshop Experience of the Senses, on which participants reported emotions and feelings experienced during the sessions, such as: fear, anxiety, craving, denial, pleasure and displeasure. Results It was identified a universe of sensations that can be translated into a sense-perception reframing about themselves and their surroundings. Conclusion The participants presented a sensory dullness, relating the experienced stimuli to the consumption of psychoactive substances, demonstrating a strong equivalence between the proposed activity and substance dependence. This activity enabled an interdisciplinary approach, through knowledge and interventions exchange. Disclosure of interest The authors have not supplied their declaration of competing interest.
Clinical efficacy of Rigan and Arginine in the treatment of hepatic encephalopathy caused by cirrhosis of liver

Field: Medicine (Health Sciences)

Objective To observe the effect of L-ornithine-L-aspartate and Rigan in the treatment of liver cirrhosis complicated with hepatic encephalopathy.Methods Eighty-four cases patients of liver cirrhosis complicated with hepatic encephalopathy were divided into two groups,forty-eight cases in observation group were given Rigan and Arginine,and forty cases in control group were only given Arginine.Two groups of patients were given the same primary treating,based on these treatment,observation group plus Rigan and Arginine,control group plus Arginine for 7 days.The blood ammonia,TBIL and the state of mind were examined before and after treatment.Results L-ornithine-L-aspartate and Rigan reduced the blood ammonia,TBIL and improved the state of mind,it surpassed the arginine obviously(P0.05).Conclusions Rigan and Arginine has definite effect in the treatment of hepatic encephalopathy caused by cirrhosis of liver,its incidence of side effect is low,it has the value for clinical use.
USING ARTIFICIAL INTELLIGENCE MARKETING TO OPTIMIZE CUSTOMER SATISFACTION IN THE HOSPITALITY INDUSTRY

Field: Business, Management and Accounting (Social Sciences)

This research aims to create a conceptual framework that can enhance our comprehension of the role of AI marketing in the tourism industry. As one of the most crucial industries in the service sector, tourism is responsible for employing one out of every ten individuals across the globe, and contributes over ten percent to the worldwide economy. Recently, technology has profoundly transformed the tourism industry, especially in artificial intelligence (AI) and marketing fields, prompting scholars to investigate the strategic influence of these on tourism. Despite its importance, there appears to be a scarcity of research in this area. To address this gap, this research developed a conceptual framework based on personalization, customer service, content creation, campaign optimization, and predictive analytics to provide insights on how AI marketing technologies can be used to promote customer satisfaction in the tourism industry. This research highlights the current state of related academic and professional efforts and evaluates their strengths and weaknesses. Keywords: Artificial Intelligence, Marketing, Tourism, Personalization, Content, Satisfaction DOI： https://doi.org/10.35741/issn.0258-2724.58.2.3
Altering integrin engagement regulates membrane localization of Kir2.1 channels

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ABSTRACT How ion channels localize and distribute on the cell membrane remains incompletely understood. We show that interventions that vary cell adhesion proteins and cell size also affect the membrane current density of inward-rectifier K+ channels (Kir2.1; encoded by KCNJ2) and profoundly alter the action potential shape of excitable cells. By using micropatterning to manipulate the localization and size of focal adhesions (FAs) in single HEK293 cells engineered to stably express Kir2.1 channels or in neonatal rat cardiomyocytes, we establish a robust linear correlation between FA coverage and the amplitude of Kir2.1 current at both the local and whole-cell levels. Confocal microscopy showed that Kir2.1 channels accumulate in membrane proximal to FAs. Selective pharmacological inhibition of key mediators of protein trafficking and the spatially dependent alterations in the dynamics of Kir2.1 fluorescent recovery after photobleaching revealed that the Kir2.1 channels are transported to the cell membrane uniformly, but are preferentially internalized by endocytosis at sites that are distal from FAs. Based on these results, we propose adhesion-regulated membrane localization of ion channels as a fundamental mechanism of controlling cellular electrophysiology via mechanochemical signals, independent of the direct ion channel mechanogating.
PENGARUH MEDIA AUDIOVISUAL TERHADAP KEMAMPUAN BERARGUMENTASI MAHASISWA PROGRAM STUDI SASTRA CHINA DALAM MATA KULIAH “CHINA TODAY”

Field: Arts and Humanities (Social Sciences)

The achievement of the level of language skills in learning Mandarin at the tertiary level is largely determined by the level of depth of knowledge received by students. The subject "China Today" is a listening course at the advanced level, where students must respond to Mandarin language discussions in the audiovisual media. Based on the field observations, it was found that there were two ways that are consistently used among students in presenting their arguments. The first is the delivery of short reviews and arguments that just repeat a few sentences according to what are they heard in the audiovisual media. The second is the submission of a complete review (covering all aspects mentioned in the audiovisual media), then followed by personal arguments. In the final listening process, as described by Tarigan, students should use the second way to present their arguments, to prove that they had achieved to the advanced level. The aim of this research is to identify which vocabulary was taken from audiovisual media, to analyze the effect of audiovisual media on students' ability in presenting arguments in the Mandarin language. Keywords: argumentative, audiovisual, Mandarin language, media
MicroRNAs and future therapeutic applications in cancer.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Every cellular process is likely to be regulated by microRNAs (miRNAs), and an aberrant expression signature of these small non-coding RNAs is a hallmark of several diseases, including cancer. miRNA expression profiling by microarray techniques has provided a powerful tool to reveal the involvement of these tiny molecules in tumor development and progression, showing that they are differentially expressed in tumors as compared to normal tissues. Moreover, specific miRNA signatures have been associated with histopathological and clinical features, suggesting a potential role of these molecules as prognostic and predictive markers. Focusing then on their biological effects and role in cancer, it has been shown that miRNAs can function as potential oncogenes or oncosuppressor genes, depending on the cellular context and on the target genes they regulate. The possibility to modulate miRNA expression either in vitro and in vivo by developing synthetic pre-miRNA molecules or antisense oligonucleotides have at the same time provided a powerful tool to a deeper comprehension of the molecular mechanisms regulated by these molecules, and suggested the intriguing and promising perspective of their possible use in therapy. Herein we review our current knowledge about the involvement of miRNAs in cancer, and their potential as diagnostic, prognostic and therapeutic tools.
Human brucellosis: Experience from a tertiary care hospital in southern India

Field: Medicine (Health Sciences)

The aim of our study was to examine and compare the clinical presentations, complications, laboratory findings, treatment and outcome of patients with acute, subacute and chronic forms of brucellosis in a tertiary care setting. This hospital-based observational study was undertaken between April 2015 and March 2017. Patients diagnosed with brucellosis, either by blood culture and/or serology, were recruited. A total of 94 cases of brucellosis of acute, subacute and chronic forms were observed in 78.7%, 15.9% and 5.3%, respectively. Blood culture grew Brucella spp. in 70.2% cases. Serological tests showed positivity in 96.8% of the patients. Using multivariate logistic regression analysis, fever and upper back pain were significant predictors for both acute and chronic forms of the disease, respectively. There is a need to increase awareness and understand the local sero-epidemiological pattern of brucellosis as it is still little known.
Tumors and pseudotumors of the spine: a review of the main aspects in computed tomography and magnetic resonance imaging.

Field: Medicine (Health Sciences)

Poster: ECR 2012 / C-1851 / Tumors and pseudotumors of the spine: a review of the main aspects in computed tomography and magnetic resonance imaging. by: A. A. S. M. D. Santos , T. C. R. S. SANTOS, M. H. Santos, G. C. P. Campos, D. F. Melo, A. L. Cunha, M. F. A. Cavalcanti; Niteroi - Rio de Janeiro, RJ/BR
Pharmacological and antimicrobial evaluation of wood rotting fungus Lenzitus betulina (Gilled Polypore) extract

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Disease curing is a complex procedure, and requires effective management of disease is a foremost challenge.Plant based remedies including fungal species have now become essential for the management of health disorders and treatment infections, due to the cross effects of modern medicine and lower price for plant based herbal products.The present study was conducted to study pharmacological potential (analgesic, anti-inflammatory and antispasmodic activity) and antimicrobial activity of Lenzitus betulina.The ethanolic extract were used for pharmacological studies while aqueous extract was used for mycochemical analysis.The analgesic activity of Lenzitus betulina after the injection of ethanol extract at a dose of 300mg/kg the writhing was reduced to (21.00±1.73)/5 min and show 43.74% inhibition when compared with standard diclofenac sodium which reduced to (17.66±1.85)/5 min and showed 52.69% inhibition.In anti-inflammatory activity Lenzitus betulina extract was given at a dose of 300mg/kg, after 240min showed (1.13±0.8)as compared to aspirin (1.10±0.57).The extract of Lenzitus betulina given to mice at a dose of 300mg/kg, and showed results of (09.00±1.7cm)with 60.86% inhibition as compared to standard drug buscopan 07.33±0.99 with 67.65% inhibition antispasmodic activity.Antibacterial activity showed that all wood rotting fungi Lenzitus betulina extract were effective against selected bacterial strains such as (Staphylococcus aureus, Salmonella enterica and Klebisella pneumonia).It is concluded from the present study that not only angiosperms and gymnosperm plants are best for treating diseases and isolation of novel compounds to treat acute and chronic diseases.
The Production of a Cause for Activism in Argentina: Labor Organization in Call Centers

Field: Social Sciences (Social Sciences)

Abstract This paper focuses on activist labor organizing in call centers in Argentina. Following a strong tradition in anthropology that has debated the nature of resistance, it discusses previous explanations for labor organizing in call centers, critiquing the common assumption that labor conditions, work processes, and the relations that take place on the shop floor constitute the seed from which forms of resistance, protest, or activism progressively emerge. Instead, this paper describes the relations, practices, and tensions through which multiple actors came together to turn call center working conditions into a cause for political action in Argentina and the collaborations that made that process possible. Based on fieldwork with call center activists between 2012 and 2013, this paper reconstructs the forms of collective organization that established the problem of poor working conditions in call centers as a cause for political action.
Safety of Local Anaesthesia in Thyroid Surgery

Field: Medicine (Health Sciences)

In most centers, Thyroid Surgeries are done under General Anaesthesia with endotracheal intubation. We present a retrospective review of 117 thyroid surgeries done in our center from 1994 to 1998 (a 5 year period). Seventy-nine cases (67.5%) were done under local anaesthesia. The morality was zero and only one case (0.8%) was converted to general anaesthesia. Key Words: Thyroidectomy, Local Anaesthesia, Zero Mortality. Jnl of Medical Investigation and Practice Vol.2 2001: 16-18
Enhanced Kerr nonlinearity for self-action via atomic coherence in a four-level atomic system

Field: Physics and Astronomy (Physical Sciences)

Enhancement of optical Kerr nonlinearity for self-action by electro-magnetically induced transparency in a four-level atomic system including dephasing between the ground states is studied in detail by solving the density matrix equations for the atomic levels. We discern three major contributions, from energy shifts of the ground states induced by the probe light, to the third-order susceptibility in the four-level system. In this four-level system with the frequency-degenerate probes, quantum interference amongst the three contributions can, not only enhance the third-order susceptibility more effectively than in the three-level system with the same characteristic parameters, but also make the ratio between its real and imaginary part controllable. Due to dephasing between the two ground states and constructive quantum interference, the most effective enhancement generally occurs at an offset that is determined by the atomic transition frequency difference and the coupling Rabi frequency.
Metabolic effects of continuous subcutaneous insulin infusion: evidence that a rise and fall of portal vein insulin concentration with each major meal facilitates post-absorptive glycemic control.

Field: Medicine (Health Sciences)

Eighteen lean adult volunteers with insulin-requiring diabetes mellitus attempted to achieve normoglycemia using continuous subcutaneous insulin infusion (CSII) or conventional insulin therapy (CIT) in a randomized crossover trial of 68 +/- 2.5 weeks (mean +/- SEM) duration. As reported (Diabetes Care 8: 447-55, 1985) the group with absent to low beta-cell function (C-peptide negative, n = 11) attained mean post-absorptive normoglycemia only during CSII vs CIT (p less than 0.05). Only following CSII was this without change in post-absorptive serum triglyceride concentrations (-4 +/- 5.6 vs 12 +/- 4.7 mg/dl; -0.04 +/- 0.6 vs 0.14 +/- 0.05 mM, p less than 0.05) or body weight (0.01 +/- 0.02 vs 0.05 +/- 0.01 kg/week, p less than 0.05). In the group with glucagon stimulated serum C-peptide 100-400 pmol/L (C-peptide positive) responses to CSII or CIT were equal. As total daily insulin dosage (0.05 +/- 0.04 U/kg/day) was the same under all conditions, to explain the efficacy of CSII, glucoregulatory hormone responses were examined. Pre- and post-test breakfast serum free immunoreactive insulin and plasma glucagon concentrations were essentially unaffected by C-peptide or treatment status. Erythrocyte 125I-insulin binding was decreased in the C-peptide negative group only during CSII (8.6 +/- 0.5 vs 10.1 +/- 0.7%, p less than 0.005); C-peptide positive group receptor binding was consistently low (8.2 +/- 0.8, 8.4 +/- 0.9%). During CIT using intermediate-acting insulin post-lunch peripheral venous insulin failed to rise (p less than 0.05), but in the C-peptide positive group, on the basis of C-peptide responses to breakfast an undetected rise and fall of portal venous insulin was assumed to coincide with each meal. Thus, only during CIT in the C-peptide negative group, which received on average 6.4/wk/subject fewer pre-meal regular insulin boluses (p less than 0.01), was the frequency of meal-related change in portal insulinemia decreased. Consistent meal-related fluctuations in portal insulinemia inherent in CSII hepatocytes sensitized by a post-receptor mechanism to the suppressive effects of insulin on glucose output and thus were indirectly responsible for the observed improvement in glycemic control and lipid metabolism in the C-peptide negative group.
Factor Weighting of the Environmental Elements Designed for the Wandering Space of the Demented Elderly

Field: Health Professions (Health Sciences)

Potential risks of hazards associated with the wandering of demented elders include falls and fractures, to which should be taken into account by intervention and management measures. The physical environment should focus on how to provide effective intervention measure for demented elders with wandering behaviors and to make wandering become a meaningful activity for such elders. This research investigated a variety of environmental elements that may serve as therapeutic elements in the wandering space of the demented elders and studied the weight relationship among those environmental elements. Sixty-six (66) caregivers coming from six special care centers participated in this study to complete a questionnaire concerning required environmental elements for the creation of a therapeutic setting. The results showed that elements such as personal belongings and pictures were helpful to promote the demented elders' nostalgia. Other beneficial environmental elements helping to create functionally therapeutic scenarios included daylights from windows, artificial fruit, festival displays and religious statues. In addition, the appearance of animals and plants in wandering space, such as aquarium fish and flowering plants, are also important environmental elements, while other environmental elements of nostalgia images, information bulletins, drawings, pet lamb, climbing and water plants were less important in constructing a functionally therapeutic scenario.
Supplementary Material for: DAXX, ATRX, and MSI in PanNET and Their Metastases: Correlation with Histopathological Data and Prognosis

Field: Medicine (Health Sciences)

Introduction: Studies on pancreatic neuroendocrine tumors (PanNETs) regarding loss of ATRX, DAXX, or frequency of microsatellite instability (MSI) show inconclusive results. So far, data on corresponding metastaseshave not been published. Methods: We performed immunohistochemistry (IHC) of ATRX, DAXX, MSH2, MSH6, MLH1, and PMS2 on 74 PanNETs and 19 metastases. ATRX- and DAXX-negative PanNETs were further sequenced for mutations. We used polymerase chain reaction for MSI on cases with IHC loss of MSH2, MSH6, MLH1, and PMS2. Results: Immunohistochemical loss of DAXX and ATRX was observed in 8/74 (11%) and 6/74 (8%) PanNETs. Loss of DAXX immunoreactivity was statistically associated with higher tumor grade and showed a tendency toward a decreased overall survival. Sequencing of DAXX- (7/11 [64%]) and ATRX-negative (5/11 [45%]) PanNETs revealed a mutation in 6/7 (86%) and 2/5 (40%). The specificity of immunohistochemical loss of DAXX and ATRX for mutation was 80% and 67%, respectively. The expression status of DAXX compared to primary tumor differs in 2/12 (17%) lymph node metastases. We further identified 3/74 (4%) tumors as MSI, associated with a poor prognosis. Discussion/Conclusion: Our study supports the hypothesis that a loss of DAXX immunoreactivity can identify a more aggressive subtype of PanNET with high confidence, while ATRX loss is a weaker indicator. Our results also strengthen the role of DAXX immunolabeling as a prognostic marker. We could show that ATRX might be less suitable as a surrogate for sequencing. Our results indicate that IHC of DAXX and ATRX may identify PanNET subtypes as targets for more aggressive therapy.
The Dialectic of Myth: Making Meaning in the Anthropocene

Field: Arts and Humanities (Social Sciences)

This dissertation interrogates the ecological purposes behind representations of indigenous and traditional myths in contemporary Anglophone novels, specifically David Mitchell’s Cloud Atlas (2004), Margaret Atwood’s MaddAddam trilogy (2004-2014), Nnedi Okorafor’s Lagoon (2014), Alexis Wright’s Carpentaria (2010) and Susanna Clarke’s Jonathan Strange and Mr. Norrell (2006). These novels, I contend, use myths to argue that climate change is not an inevitable result of human nature but rather the product of one cultural story — what I call the Enlightenment myth — which asserts humanity’s need to dominate nature. Conversely, the Yorùbá, Waanyi Aboriginal, Celtic and new age science/spiritualist myths depicted in these novels understand humanity as incapable of mastering nature without dire consequences for both the world and ourselves. Challenging the longstanding—and frequently racist—dichotomy between civilized science and irrelevant or mystifying folk belief, my project illustrates how myths are increasingly employed as a rhetorical tool to foster ideas of human interdependence with nature. My work challenges the definition of myth as “false supposition” and instead asserts myths are always cultural stories whose merit should not be measured through claims of objectivity but rather by the cultural practices they manifest.