jimnoneill/paper-to-field-training huggingface dataset:
Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Cancer is the principal cause of death and its incidence is increasing continuously worldwide. Various treatment approaches are in practice to treat cancer, but these treatment strategies may be associated with severe side effects and also produce drug resistance. However, natural compounds have established their role in cancer management with minimal side effects. In this vista, kaempferol, a natural polyphenol, mainly found in vegetables and fruits, has been revealed to have many health-promoting effects. Besides its health-promoting potential, its anti-cancer potential has also been described in in vivo as well as in in vitro studies. The anti-cancer potential of kaempferol has been proven through modulation of cell signaling pathways in addition to the induction of apoptosis and cell cycle arrest in cancer cells. It leads to the activation of tumor suppressor genes, inhibition of angiogenesis, PI3K/AKT pathways, STAT3, transcription factor AP-1, Nrf2 and other cell signaling molecules. Poor bioavailability of this compound is one of the major limitations for its proper and effective disease management actions. Recently, some novel nanoparticle-based formulations have been used to overcome these limitations. The aim of this review is to provide a clear picture regarding the mechanism of action of kaempferol in different cancers through the modulation of cell signaling molecules. Besides this, strategies to improve the efficacy and synergistic effects of this compound have also been described. However, more studies are needed based on clinical trials to fully explore the therapeutic role of this compound, especially in cancer treatment.
IMPACTS OF BINDER AND DISINTEGRANT ON DETAM II SOYBEAN (GLYCINE MAX (L.) MERR) TABLET MADE BY DRY GRANULATION

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Keywords: Detam II black soybean (Glycine max (L.) Merr), Tablet, Binder, Disintegrant, Disintegration time \nBlack soybean (Glycine max L. Merr) Detam II Variety has a scavenging activity and total phenolic compound higher than yellow soybean. As a natural compound, the flow properties of black soybean (Glycine max (L.) Merr) Detam II powder is poor due to its high content of moisture, so it must be made by dry granulation method. Dry binder and disintegrant have opposite functions on tablets formula where one serves to increase consolidation between particles while other accelerate the disintegration time as the rate limiting step of dissolution. The effects of disintegrant and dry binder variation on the physical characteristics of black soybean tablets have been observed. The variations of polyvinylpyrrolidone (PVP)-K30 combined with Plasdone S-630 were used as binders, while sodium starch glycolate (SSG) was used as a disintegrant. Approximately 4% of PVP-K30 as a single binder in the formula component provides better hardness and friability value of tablets, but the disintegration time was longer than other formulas. The amount of SSG used was increased to 4 and 8%, respectively in the formula component. 4% was the ideal amount of SSG as a disintegrant to get the best physical tablet characteristics and also disintegration time, about 4.45 minutes. Increasing the amount of SSG has no significant effect on the disintegration time even tends to slow down.
Enantioselective Synthesis of α-Amino Acids and Monosubstituted 1,2-Diamines by Conjugate Addition of 4-Phenyl-2-oxazolidinone to Nitroalkenes

Field: Chemistry (Physical Sciences)

The addition of the potassium salt of (R)- or (S)-4-phenyl-2-oxazolidinone to monosubstituted nitroalkenes proceeded with very good diastereoselectivity. Several of the addition products were converted into α-amino acids and monosubstituted 1,2-diamines of high enantiomeric purity.
Scaling and Evaluation of Whole- body Vibration by the Category Judgment Method

Field: Engineering (Physical Sciences)

Quantitative evaluation of of is an important aspect to consider when evaluating the nature of products or the establishment of design‑objective values during vehicle development. In this research the category judgment method which is one of the scaling methods was used to create an assessment scale for evaluation of whole‑body vibration to solve this problem. To scrutinize the effect of the difference in the frequency component of the vibration on evaluation three kinds of random signals with different spectrum were used in our experiment. Consequently while the quantitative relation between a vibration stimulus and degree of comfort became clear it turned out that when a vibration contained more low frequency components the degree of comfort declines even though the acceleration level is the same.
Self-Accelerating Decomposition Temperature (SADT) von Azobisisobutyronitril (AIBN)

Field: Chemical Engineering (Physical Sciences)

Im Vortrag wird uber Untersuchungen zur thermischen Stabilitat (Bestimmung der SADT = Self-Accelerating Decomposition Temperature) von 2,2‘-Azobisisobutyronitril (AIBN) in realen Packstucken unterschiedlicher Grose sowie in Dewar-Gefasen berichtet. Die Packstucke mit 5 kg, 20 kg bzw. 50 kg AIBN wurden nach der UN-Methode H.4 untersucht, die Versuche mit den Dewar-Gefasen nach UN-Methode H.4. Zusatzlich wurden experimentelle Daten mittels DSC (Differential Scanning Calorimetry) unter Verwendung druckfester Gefase bestimmt. Die experimentellen Daten wurden fur weitergehende Untersuchungen/Simulationen unter Verwendung realer kinetischer Modelle bereitgestellt. Letztendlich konnte nachgewiesen werden, dass mittels Simulation die SADT von AIBN in Abhangigkeit von der Packstuckgrose sehr genau, d. h. in guter Ubereinstimmung mit den Packstuckversuchen, bestimmt werden kann.
Compact bandstop filters using coupled lines and open/short stubs with multiple transmission poles

Field: Engineering (Physical Sciences)

A compact bandstop filter (BSF) using parallel‐coupled lines and open stubs with four transmission poles (TPs) is proposed. Through theoretical equation deduction, the positions of these four TPs can be obtained. Good roll‐off skirts and stopband suppression characteristics of the BSF can be realised with the help of multiple TPs. To improve transition band roll‐off rates, another BSF with five TPs is designed, where a short‐circuited T‐stub is loaded on the middle of the above BSF circuit structure. For demonstration, two filter examples with centre frequencies at 2 and 1.8 GHz are implemented with generation of four and five TPs, respectively, for theoretically calculated certification. Good agreement between simulated and measured results validates the design method.
Differences in Leaf Functional Traits betweenSimple and Compound Leavesof Canavalia maritime

Field: Agricultural and Biological Sciences (Life Sciences)

The response of leaf functional traits to the shift in environmental variables can raise plant adaptiveness in a wide variety of habitats and subsequently broaden their ecological niche.This study aims to determine the differences in leaf functional traits between simple and compound leaves of Canavalia maritime to illuminate the mechanisms underlying the ecological strategy of plant species with different leaf forms.Single-leaf wet weight of compound leaves of C. maritime was significantly lower than that of simple leaves of C. maritime.Thus, compound leaves of C. maritime possess higher resource capture ability as well as higher relative growth rate than simple leaves of C. maritime.The petiole length of compound leaves of C. maritime was significantly higher than that of simple leaves of C. maritime.Thus, the biomass allocation to petiole for compound leaves of C. maritime was significantly higher than that of simple leaves of C. maritime.Meanwhile, the higher range of phenotypic plasticity of SLA of compound leaves of C. maritima may enhance the advantage in resource (especially sunlight) capture and use efficiency by shifting the material investment per unit area and per lamina.
A Short History of Florida Entomologist in Recognition of 100 Years of Publication

Field: Agricultural and Biological Sciences (Life Sciences)

Capinera, John L. (2017): A short history of Florida Entomologist in recognition of 100 years of publication. Florida Entomologist 100 (1): 1-4, DOI: 10.1653/024.100.0101, URL: http://www.bioone.org/doi/10.1653/024.100.0101
The effects of pneumoperitoneum and patient position on the perfusion index and pleth variability index during laparoscopic bariatric surgery

Field: Medicine (Health Sciences)

Objective: Limited data are available on the use of the perfusion index (PI) and the pleth variability index (PVI) during laparoscopicbariatric surgery. We investigated the effects of pneumoperitoneum and the reverse Trendelenburg position on these indices.Materials and Methods: PI, PVI, heart rate (HR), blood pressure, SpO2 and ventilation parameters were recorded before anaesthesiainduction (T0), 5 min after endotracheal intubation (T1), immediately before surgery, after the patient had been in the reverseTrendelenburg position for 5 min (T2), after inflating the abdomen with CO2 in reverse Trendelenburg (T3), after the abdomen hadbeen deflated (T4) and 5 min after extubation (T5).Results: General anaesthesia induced an increase in the PI (P&lt;.001), and a decrease in the PVI (P=.002). The PI and PVI values werenot affected during T2 or T3. Pneumoperitoneum caused an increase in mean arterial pressure (MAP) and a decrease in HR. PVI andMAP decreased during T4, but the PI and HR remained unchanged. PVI, HR and MAP increased during T5.Conclusion: Our data suggest that the reverse Trendelenburg position and pneumoperitoneum did not affect the PI or PVI values,whereas deflation decreased the PVI in morbidly obese patients under general anaesthesia.
Estimating Counterparty Exposure in Interest Rate Derivatives Using the Heath-Jarrow-Morton Framework for Interest Rate Simulation

Field: Decision Sciences (Social Sciences)

I denne oppgaven har risikomålene Expected Shortfall (ES), Potential Future Exposure (PFE) og Expected Positive Exposure (EPE) blitt studert for å undersøke motpartseksponering for en rentebytteavtale hvor flytende rente betales og en fast rente mottas. Heath-Jarrow-Morton-rammeverket for rentemodellering har blitt brukt for å generere fremtidige scenarioer for markedsutvikling ved bruk av Monte Carlo-simulering. Videre har de simulerte fremtidige rentene blitt brukt til å verdsette rentebytteavtaler ved hvert simulerte tidssteg innenfor rentebytteavtalens levetid. Til slutt er samlingen av de simulerte prisene på rentebytteavtalene brukt til å generere verdier for motpartseksponeringen, representert ved riskikomålene ES, PFE og EPE. \n\nRisikomålene har blitt vurdert ut i fra hvilken grad de har evnet å forutse motpartseksponeringen som ville ha oppstått ved reelle rentebytteavtaler i forskjellige perioder mellom 2005 og 2019. Resultatene viser at ES presterer bedre enn PFE, men ingen av dem klarer i tilstrekkelig grad å forutse den virkelige eksponeringen i perioder hvor finansmarkedene er presset, slik som under finanskrisen i 2008. \n\nEt skifte mot ES som det primære risikomålet for rentebytteavtaler har blitt diskutert fra et regulatorisk ståsted, slik at det dermed også følger trenden for andre aktivaklasser i etterkant av finanskrisen.
Mortality Reduction Associated With β-Adrenoceptor Inhibition in Chronic Heart Failure Is Greater in Patients With Diabetes

Field: Medicine (Health Sciences)

OBJECTIVE Diabetes increases mortality in patients with chronic heart failure (CHF) and reduced left ventricular ejection fraction. Studies have questioned the safety of β-adrenoceptor blockers (β-blockers) in some patients with diabetes and reduced left ventricular ejection fraction. We examined whether β-blockers and ACE inhibitors (ACEIs) are associated with differential effects on mortality in CHF patients with and without diabetes. RESEARCH DESIGN AND METHODS We conducted a prospective cohort study of 1,797 patients with CHF recruited between 2006 and 2014, with mean follow-up of 4 years. β-Blocker dose was expressed as the equivalent dose of bisoprolol (mg/day) and ACEI dose as the equivalent dose of ramipril (mg/day). Cox regression analysis was used to examine the interaction between diabetes and drug dose on all-cause mortality. RESULTS Patients with diabetes were prescribed larger doses of β-blockers and ACEIs than were patients without diabetes. Increasing β-blocker dose was associated with lower mortality in patients with diabetes (8.9% per mg/day; 95% CI 5–12.6) and without diabetes (3.5% per mg/day; 95% CI 0.7–6.3), although the effect was larger in people with diabetes (interaction P = 0.027). Increasing ACEI dose was associated with lower mortality in patients with diabetes (5.9% per mg/day; 95% CI 2.5–9.2) and without diabetes (5.1% per mg/day; 95% CI 2.6–7.6), with similar effect size in these groups (interaction P = 0.76). CONCLUSIONS Increasing β-blocker dose is associated with a greater prognostic advantage in CHF patients with diabetes than in CHF patients without diabetes.
Recursive Utility and Stochastic Differential Utility: From Discrete to Continuous Time

Field: Mathematics (Physical Sciences)

In this thesis, mathematical research questions related to recursive utility and stochastic differential utility (SDU) are explored.

First, a class of backward equations under nonlinear expectations is investigated: Existence and uniqueness of solutions are established, and the issues of stability and discrete-time approximation are addressed. It is then shown that backward equations of this class naturally appear as a continuous-time limit in the context of recursive utility with nonlinear expectations.

Then, the Epstein-Zin parametrization of SDU is studied. The focus is on specifications with both relative risk aversion and elasitcity of intertemporal substitution greater that one. A concave utility functional is constructed and a utility gradient inequality is established.

Finally, consumption-portfolio problems with recursive preferences and unspanned risk are investigated. The investor's optimal strategies are characterized by a specific semilinear partial differential equation. The solution of this equation is constructed by a fixed point argument, and a corresponding efficient and accurate method to calculate optimal strategies numerically is given.
Numerical Solution of Singularly Perturbed Delay Differential Equations with Layer Behavior

Field: Mathematics (Physical Sciences)

We present a numerical method to solve boundary value problems (BVPs) for singularly perturbed differential-difference equations with negative shift. In recent papers, the term negative shift has been used for delay. The Bezier curves method can solve boundary value problems for singularly perturbed differential-difference equations. The approximation process is done in two steps. First we divide the time interval, intoksubintervals; second we approximate the trajectory and control functions in each subinterval by Bezier curves. We have chosen the Bezier curves as piecewise polynomials of degreenand determined Bezier curves on any subinterval byn+1control points. The proposed method is simple and computationally advantageous. Several numerical examples are solved using the presented method; we compared the computed result with exact solution and plotted the graphs of the solution of the problems.
David Lewis on indicative and counterfactual conditionals

Field: Arts and Humanities (Social Sciences)

Journal Article David Lewis on indicative and counterfactual conditionals Get access Robert J. Fogelin Robert J. Fogelin Dartmouth CollegeHanover, NH 03755-3592, USARobert.J.Fogelin@Dartmouth.edu Search for other works by this author on: Oxford Academic Google Scholar Analysis, Volume 58, Issue 4, October 1998, Pages 286–289, https://doi.org/10.1093/analys/58.4.286 Published: 01 October 1998
Omnes compleant: A conductor's resource guide to the Office of Compline.

Field: Arts and Humanities (Social Sciences)

Compline is the last of the liturgical celebrations within the daily cycle of the Roman Catholic Divine Office. Intended for observance at the completion of the day, or prior to sleep, Compline is the office immediately following Vespers and, as with each of the hours of the Divine Office, contains a corpus of plainchant in the form of psalms, a hymn, antiphons, and smaller chants such as versicles, responsories, canticles, and others. This dissertation is primarily intended to serve as a resource for conductors and other musicians who are interested in exploring Compline in performance, whether in a liturgical or a concert setting. The document begins with an introductory chapter to establish the purpose and need for the study, as well as to define its parameters and to discuss related literature and potential future research. Chapter II provides an historical overview of the evolution of Compline from its origins in early Christianity to the Second Vatican Council in the twentieth century. Conductors who wish to integrate Compline plainchant with performances of related polyphonic settings will find in subsequent chapters original transcriptions in modern notation of all Compline plainchant from the Roman Breviary; original English translations of all Latin texts; an extensive catalog of polyphonic settings spanning all periods of music history; and a model concert program for a Compline-centered performance, complete with original performance editions of 12 Medieval and Renaissance polyphonic motets for various combinations of voices.
The Hexapodopter: A holonomic flying hexapod

Field: Engineering (Physical Sciences)

This document introduces an air-land robotic platform called Hexapodopter, capable of ground locomotion and vertical take-off and landing (VTOL). For walking, each of the limbs feature three degrees of freedom (DoF); for flying, the thrust is provided by a set of motors and propellers mounted on every limb. Due to its mechanical design, the Hexapodopter can reconfigure the thrust vectors of propellers into a true holonomic configuration during flight; in other words, the vehicle is capable of controlling individually its 6 degrees of freedom on the air, without reorienting any of the thrust motors nor the body. In this document, we present a formal analysis of the holonomic properties of the vehicle, not found in related works, as well as a control architecture for the Hexapodopter, exploiting these properties, shown through numerical test results.
Increased expression of acidic and basic fibroblast growth factors in chronic pancreatitis.

Field: Medicine (Health Sciences)

Acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) belong to a family of mitogenic polypeptides that are involved in cellular proliferation and differentiation. In this study we investigated the potential role of aFGF and bFGF in chronic pancreatitis (CP), a fibrotic condition associated with acinar cell dedifferentiation and atrophy, and fibroblastic proliferation. By immunohistochemistry, aFGF and bFGF were abundant in pancreatic ductal and acinar cells in pancreatic tissues from CP patients. Immunoblotting with the same highly specific monoclonal antibodies demonstrated a marked increase in aFGF and bFGF in pancreatic homogenates from CP patients by comparison with the normal pancreas. Northern blot analysis indicated that, by comparison with normal controls, 16 of 21 CP tissues exhibited a 14-fold increase in aFGF mRNA levels, and 19 of 21 CP tissues exhibited a 15-fold increase in bFGF mRNA levels. In situ hybridization confirmed that this overexpression occurred in ductal and acinar cells, and indicated that both mRNA moieties colocalized with their respective proteins. These findings suggest that aFGF and bFGF may either be involved in the pathobiological mechanisms that occur in CP, or that their overexpression may be the consequence of other perturbations that occur in this disorder.
From Lightweight, Proactive Information Delivery to Business Process-Oriented Knowledge Management

Field: Computer Science (Physical Sciences)

Abstract: Knowledge work processes consist of interleaved agile, weakly-structured processes and strictly-structured processes. Knowledge management approaches for weakly-structured, ad-hoc knowledge work processes need to be lightweight, i.e., they cannot rely on high upfront modeling effort. However, approaches for business processoriented knowledge management require intensive modeling activities. In this paper, we introduce a bottom-up strategy for proactive information delivery to cover the complete spectrum of knowledge work processes in different phases, and present a series of prototypes realizing selected phases of this strategy. Among these is a novel prototype for supporting weakly-structured processes by integrating a standard to-do list application with a state-of-the-art document classification system. The resulting system allows for a task-oriented view on an office worker’s personal knowledge space in order to realize a proactive and context-sensitive information support during her daily, knowledge-intensive tasks. Key Words: Weakly-structured workflows, agile workflows, proactive information delivery, personal knowledge space
Machine condition monitoring using artificial intelligence: The incremental learning and multi-agent system approach

Field: Computer Science (Physical Sciences)

Machine condition monitoring is gaining importance in industry due to the \nneed to increase machine reliability and decrease the possible loss of production \ndue to machine breakdown. Often the data available to build a condition \nmonitoring system does not fully represent the system. It is also often common \nthat the data becomes available in small batches over a period of time. Hence, \nit is important to build a system that is able to accommodate new data as \nit becomes available without compromising the performance of the previously \nlearned data. In real-world applications, more than one condition monitoring \ntechnology is used to monitor the condition of a machine. This leads to large \namounts of data, which require a highly skilled diagnostic specialist to analyze. \nIn this thesis, artificial intelligence (AI) techniques are used to build a \ncondition monitoring system that has incremental learning capabilities. Two \nincremental learning algorithms are implemented, the first method uses Fuzzy \nARTMAP (FAM) algorithm and the second uses Learn++ algorithm. In addition, \nintelligent agents and multi-agent systems are used to build a condition \nmonitoring system that is able to accommodate various analysis techniques. \nExperimentation was performed on two sets of condition monitoring data; the \ndissolved gas analysis (DGA) data obtained from high voltage bushings and the \nvibration data obtained from motor bearing. Results show that both Learn++ \nand FAM are able to accommodate new data without compromising the performance \nof classifiers on previously learned information. Results also show \nthat intelligent agent and multi-agent system are able to achieve modularity \nand flexibility.
Trailer on "Community" and "Women Power" exhibitions

Field: Arts and Humanities (Social Sciences)

A trailer accompanying the exhibitions at the National Museum in Szczecin: "Community" and "Woman Paower" (22 November 2021 – 16 January 2022) carried out as part of the DUOS Festival, which took place in Kilifi, Kenya (August/September, 2021). Organized by the Academy of Art in Szczecin and the National Museum in Szczecin as a part of the Transcultural Perspectives in Art and Art Education (TPAAE) project.