jimnoneill/paper-to-field-training huggingface dataset:
A molecular switch from tumor suppressor to oncogene in ER+ve breast cancer: Role of androgen receptor, JAK-STAT, and lineage plasticity

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Cancers develop resistance to inhibitors of oncogenes mainly due to target-centric mechanisms such as mutations and splicing. While inhibitors or antagonists force targets to unnatural conformation contributing to protein instability and resistance, activating tumor suppressors may maintain the protein in an agonistic conformation to elicit sustainable growth inhibition. Due to the lack of tumor suppressor agonists, this hypothesis and the mechanisms underlying resistance are not understood. In estrogen receptor (ER)-positive breast cancer (BC), androgen receptor (AR) is a druggable tumor suppressor offering a promising avenue for this investigation. Spatial genomics suggests that the molecular portrait of AR-expressing BC cells in tumor microenvironment corresponds to better overall patient survival, clinically confirming AR’s role as a tumor suppressor. Ligand activation of AR in ER-positive BC xenografts reprograms cistromes, inhibits oncogenic pathways, and promotes cellular elasticity toward a more differentiated state. Sustained AR activation results in cistrome rearrangement toward transcription factor PROP paired-like homeobox 1, transformation of AR into oncogene, and activation of the Janus kinase/signal transducer (JAK/STAT) pathway, all culminating in lineage plasticity to an aggressive resistant subtype. While the molecular profile of AR agonist–sensitive tumors corresponds to better patient survival, the profile represented in the resistant phenotype corresponds to shorter survival. Inhibition of activated oncogenes in resistant tumors reduces growth and resensitizes them to AR agonists. These findings indicate that persistent activation of a context-dependent tumor suppressor may lead to resistance through lineage plasticity-driven tumor metamorphosis. Our work provides a framework to explore the above phenomenon across multiple cancer types and underscores the importance of factoring sensitization of tumor suppressor targets while developing agonist-like drugs.
Multicultural thinking and practice in music therapy training

Field: Health Professions (Health Sciences)

This paper explores the notion of multicultural music therapy as defined by Hadley (2013) and Mahoney (2015) and how the practice of this can impact on music therapy training. Through the lens of her own practice, the author critically and reflexively attempts to examine her own assumptions and how this may impact on her music therapy training practices, including recruitment of students for training places, and working with diversity during the training. Drawing on both clinical and research work she aims to illuminate areas for consideration and discussion which, although particularly relevant for music therapy practice, can extend beyond these parameters.
One-stage thoracoscopic surgery for bilateral spontaneous pneumothorax

Field: Medicine (Health Sciences)

両側気胸に対する胸腔鏡下一期的両側気胸手術例について検討した．2002年4月から2009年4月の7年間に横浜労災病院呼吸器外科で治療した全自然気胸718例のうち男性10例，女性2例の計12例（1.53％）を対象とした．対象の平均年齢22.8±5.9歳（17～37歳），初診時の診断は同時両側気胸7例，異時両側気胸5例，平均気胸回数は2.7±1.2回（2～5回）であった．手術適応は，同時性では全例を適応とし，異時性では初発側非手術例でかつ初発側から対側発症までの期間が短い症例を適応とした．術前管理は，同時性では虚脱度が高度な側のみに胸腔ドレナージを施行した症例が多く，異時性では虚脱度に応じた治療を行った．手術は同時性では虚脱軽度の側から施行し，異時性では患側から施行した．体位変換をしたのち対側を手術した．術後平均在院日数は，2.4日であった．今回の検討で，他の報告よりも術後在院日数が短かったが，ドレーン管理の工夫によるものと考えられた．
Switching the future of literature in the library of health sciences University of Federal Ceara

Field: Health Professions (Health Sciences)

This paper presents the current status of services for access to documents in the Library of the Health Sciences, Federal University of Ceará by service Switching Bibliography. Aims to demonstrate, numerically, the search for bibliographic exchange in that library in the period from 2000 to 2012, consider alternatives to meet the demands of university for full articles. Questioning the maintenance of networks and COMUT SCAD in the century of electronic access and open access to scientific publications. Descriptive study that points to a reduction in the use of service switching bibliographic year after year. It is considered that the units of information should direct their efforts to the training of its members towards promoting self-sufficiency of the same in relation to the search and acquisition of wishing.
Phase-change control of anomalous Hall effect in ferromagnetic MnBi thin films

Field: Materials Science (Physical Sciences)

We have experimentally demonstrated a phase change control of Hall effects in ferromagnetic MnBi thin films at room temperature. Two distinct ferromagnetic phases, i.e., a low-temperature phase and a quenched high-temperature phase, were obtained by slow-cooling or quenching the sputtered MnBi films. The measurement of Hall effects showed that the anomalous Hall resistivity has different coercivity and remanence between the two phases. By optimizing the Mn/Bi ratio, it is even possible to repeatedly switch the sign of Hall resistivity, which could be utilized as a concept of phase-change memory based on ferromagnetic transport.
(WA) 0822-4602-4567 Karangan Bunga HUT Hari Dharma Wanita Pramuka Mempawah Kalimantan Barat

Field: Social Sciences (Social Sciences)

0822-4602-4567 (KIRIM), Kirim Bunga Ucapan Hut Hari Dharma Wanita Pramuka Kodim Mempawah Kalimantan Barat\n\nLangsung Kirim Bunga Ucapan Hut Hari Dharma Wanita Pramuka Kodim PT Tbk Bhayangkara Bhayangkari Mempawah Kalimantan Barat, Kirim Bunga Ucapan Hut Hari Dharma Wanita Pramuka Kodim Karangsatria, Kirim Bunga Ucapan Hut Hari Dharma Wanita Pramuka Kodim Satriajaya, Kirim Bunga Ucapan Hut Hari Dharma Wanita Pramuka Kodim Satriamekar, Kirim Bunga Ucapan Hut Hari Dharma Wanita Pramuka Kodim Sriamur, Kirim Bunga Ucapan Hut Hari Dharma Wanita Pramuka Kodim Srijaya, Kirim Bunga Ucapan Hut Hari Dharma Wanita Pramuka Kodim Srimahi, Kirim Bunga Ucapan Hut Hari Dharma Wanita Pramuka Kodim Srimukti\n\nToko Karangan Bunga Papan 24 Jam 0822-4602-4567\n\n\n#KirimBungaUcapanHutMempawahKalimantanBarat, #KirimBungaUcapanHutKarangsatria, #KirimBungaUcapanHutSatriajaya, #KirimBungaUcapanHutSatriamekar, #KirimBungaUcapanHutSriamur, #KirimBungaUcapanHutSrijaya, #KirimBungaUcapanHutSrimahi, #KirimBungaUcapanHutSrimukti\n\n
Metabolic engineering for Escherichia coli BW25113 for the production of 5-Aminolevulinic Acid based on CRISPR/Cas9 mediated gene knockout and metabolic pathway modification

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract 5-Aminolevulinic acid (ALA) recently received much attention due to its potential application in many fields. In this study, an ALA production strain of Escherichia coli was constructed by rational metabolic engineering and stepwise improvement based on known regulatory and metabolic information and CRISPR/Cas9 mediated gene knockout. A metabolic strategy to produce ALA directly from glucose in this recombinant E. coli via the C5 pathway was applied herein. The rational metabolic engineering by gene knockouts significantly improved ALA production from 662.3 to 1601.7 mg/L. In addition, we tried to synergistically produce ALA via the C4 pathway in recombinant strain. The expression of a modified hemA gene, encoding an ALA synthase from Rhodobacter sphaeroides , improved ALA production from 1601.7 to 2099.7 mg/L. After 24 h cultivation, a yield of 0.210 g ALA per g glucose was achieved by constructed E. coli D5:FYABD. These results suggest that an industrially competitive strain can be efficiently developed by metabolic engineering based on combined rational modification and optimization of gene expression.
Value of changes of P wave dispersion in patients with coronary artery disease during treadmill test

Field: Medicine (Health Sciences)

Objective To evaluate the value of P wave dispersion measured in patients with coronary artery disease during treadmill test.Methods Patients with coronary artery disease receiving treadmill test were selected.P wave dispersion in 22 patients with positive result(positive group) and in 25 patients with negative result(negative group) were measured and P wave dispersion in two groups were analyzed before and during treadmill test.Results Before treadmill test,P wave dispersion had no significant difference in two groups,(24±9)ms and(26±8)ms respectively(P0.05);during treadmill test,P wave dispersion in positive group increased obviously(P0.05),and P wave dispersion in negative group did not change significantly compared to before treadmill test(P0.05).Conclusion The increase of P wave dispersion maybe a clinical reference for evaluating myocardial ischemia in patients with coronary artery disease during treadmill test.
Lung Cancer Among White South Africans

Field: Medicine (Health Sciences)

MEDICAL JOURNAFor children in hospital we are amongst the pioneers in co-operating with hospital authorities to introduce play into the wards.The " play lady " does much to alleviate the fears and sense of insecurity attending going to hospital.Paediatric staff are beginning to discover that sick children absorbed in play recover more quickly and suffer less from the emotional upset sometimes following the hospital experience.-Iam, etc.,
A Case of a Small-Breed Dog with Diet-Related Dilated Cardiomyopathy Showing Marked Improvements in Cardiac Morphology and Function after Dietary Modification

Field: Veterinary (Health Sciences)

An 11-year-old intact female Papillion weighing 2.1 kg was referred to our institution with the main complaint of shallow, rapid breathing. At the first visit (day 0), although clinical signs improved due to the use of medication from the primary hospital, transthoracic radiography and echocardiography revealed left heart enlargement and left ventricular dysfunction. A clinical diagnosis of dilated cardiomyopathy (DCM) was made and oral administration of pimobendan, temocapril, and taurine was initiated. However, on day 10, the respiratory status worsened and furosemide was prescribed. On day 54, no significant improvement in heart size was observed. Additionally, the diet that this patient received met the recommendation for diet-related DCM by the U.S. Food and Drug Administration, and the patient’s diet was changed from a grain-free diet to a grain-containing diet. On day 1191, the patient’s respiratory status was stable and no clinical signs were observed. Transthoracic radiography and echocardiography revealed an improvement in left heart size. Additionally, improvements in the left and right ventricular myocardial strains were observed after changing the diet. We suggest that it may be necessary to suspect a dietary association with dilated cardiomyopathy, and a good prognosis might be expected by dietary modification, even in small-breed dogs.
Thermovision as a non – destructive method of technical condition assessment: case study in a smart building

Field: Engineering (Physical Sciences)

Abstract Currently, more and more emphasis is placed on building energy-efficient buildings from the highest quality materials to keep heat and energy losses as low as possible. Relatively, such buildings are much more expensive than traditional buildings due to the technology that is used in them. This applies to HVAC systems, renewable energy sources and etc. This paper presents the correctness of the thermal insulation of the Energis intelligent building at the Kielce University of Technology with the use of a thermal imaging camera. Measurements and photos were taken outside and inside the building, in the winter, in the late afternoon. This research topic was undertaken because few works and articles offer thermal imaging studies of smart buildings. The analysis of the thermograms showed differences between the surface of the windows and the walls from the inside, and additionally a place in the room in which you can see how cold is trying to penetrate the interior. The study provided data on thermal insulation of the tested building, its assessment and correctness of execution.
Analysis of the Effect of Piezoelectric Patches on the Behavior of Adhesively Bonded Scarf Joints — An Analytical Study

Field: Engineering (Physical Sciences)

In order to reduce the maximum peel and shear stress concentrations in the adhesive layer, a smart adhesively bonded scarf joint system was developed by surface bonding of piezoelectric patches onto a typical scarf joint. The forces and bending moments at the edges of the developed smart joint system can be adaptively controlled by adjusting the applied electric field on the piezoelectric patches, thus reducing the peel and shear stresses concentration in the adhesive layer. In order to verify the effect of surface bonding of piezoelectric patches in smart scarf adhesive joints, an analytical model was developed to evaluate the shear stress distribution and to predict the peel stress. It was established that the piezoelectric patched joint could reduce the stress concentrations at the scarf joint edges. The influence of the electric field and the effects of the scarf angle and the adherend Young's modulus on the peel and shear stresses were investigated. It was found that the effect of scarf angle is more significant at higher angles to raise the stresses. The effect of the electric field on the shear stress is more significant than on the peel stress.
Locate! - When do Users Disclose Location?

Field: Psychology (Social Sciences)

Location information and traces (via tracking) can reveal vast amounts of information about a user: where she lives, works, and even which restaurants or friends she visits. Therefore, this information should be handled with sufficient concern and care. Willingness to disclose one’s location is influenced by various factors including who is asking the location and what the reason for the location request is, as well as individual characteristics such as one’s privacy concerns. This paper outlines a study aimed at determining the relationship between these factors and users’ willingness to share their location with others using a mobile device. To study this, we developed a mobile application that lets the users share their current location with others at various levels of accuracy. Using the application, we ran a field study simulating the communication between the participants and their various contacts. Our results show that mainly the personal, rather than external factors influence the tendency for location disclosure. Users with lower privacy concerns regarding the accuracy of personal information share their location with more accuracy. Also, people who generally feel close with others tend to disclose their location more accurately.
Low-Loss 140-175 GHz MMIC-to-Waveguide Transitions and MMIC-to-MMIC Interconnections

Field: Engineering (Physical Sciences)

This work presents two types of direct MMIC-to-waveguide (WG) transitions and two types of MMIC-to-MMIC interconnections between 140 to 175 GHz. A periodic electromagnetic bandgap (EBG) structure is used in the MMIC-to-WG transitions to suppress unwanted resonances and help the coupling between the microstrip mode and the waveguide mode. Measurement of the two types of MMIC-to-WG transitions shows 0.38 to 0.63 dB and 0.32 to 0.62 dB insertion loss respectively. Insertion loss of hot-via based MMIC-to-MMIC interconnection is found to be between 0.54 to 1.88 dB. Another MMIC-to-MMIC interconnection method using a piece of CPW quartz board achieves 0.31 to 1.08 dB insertion loss.
The control process of physical education of students of agrarian type

Field: Social Sciences (Social Sciences)

Forms and methods of process of physical education of students' young people control are considered. 1844 students were inspected. The level of physical development of students is certain. Base factors are set for providing of high professional level of future specialists. Optimum methods and forms of differentiation of process of physical education and independent training of students are grounded. Basic directions of perfection of process of physical education of students control are certain.
Physics background in luminosity measurement at 1 TEV at ILC

Field: Physics and Astronomy (Physical Sciences)

In this paper we present the results of the investigation\nof the influence of two-photon processes on luminosity\nmeasurement at future linear collider ILC at center-ofmass\nenergy of 1 TeV. The overall choice of selection\ncriteria for the luminosity measurement with the\nrespect to leading sources of systematic error is\ndiscussed. The potential of individual selection criteria\nto suppress physics background is discussed and\ncomparison with the 500 GeV case is presented.
Self‐Assembled Virus‐Like Particle Vaccines via Fluorophilic Interactions Enable Infection Mimicry and Immune Protection

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Influenza epidemics persistently threaten global health. Vaccines based on virus‐like particles (VLPs), which resemble the native conformation of viruses, have emerged as vaccine candidates. However, the production of VLPs via genetic engineering remains constrained by challenges such as low yields, high costs, and being time consuming. In this study, a novel VLP platform is developed that could mimic infection and confer influenza protection through fluorination‐driven self‐assembly. The VLPs closely mimick the key steps in viral infection including dendritic cell (DC) attachment and pH‐responsive endo‐lysosomal escape, which enhances DC maturation and antigen cross‐presentation. It is also observed that the VLPs migrate from the injection site to the draining lymph nodes efficiently. Immunization with VLPs triggers both Th1 and Th2 cellular responses, thereby inducing an improved CD8 + T cell response along with strong antigen‐specific antibody responses. In several infected mouse models, VLP vaccines ameliorate weight loss, lung virus titers, pulmonary pathologies, and confer full protection against H1N1, H6N2, H9N2, and mixed influenza viruses. Therefore, the results support the potential of VLPs as an effective influenza vaccine with improved immune potency against infection. A methodology to generate VLPs based on fluorophilic interactions, which can be a general approach for development of pathogenic VLPs, is reported.
In Situ Sequestration of a Hydraulic Fracturing Fluid\nin Longmaxi Shale Gas Formation in the Sichuan Basin

Field: Environmental Science (Physical Sciences)

Due\nto high salinity and complex components including varied inorganic\nsalts, organic agents, released heavy metals, radioactive elements\nand clastic particles, environmental and economical treatments of\na huge amount of flowback wastewater from shale gas wells have attracted\nboth public concerns and industrial interest. Unlike the existing\nmethods such as deep well reinjection and recycling, this paper explores\nthe feasibility of directly reserving an injected hydraulic fracturing\n(HF) fluid in a shale formation utilizing its strong capillary imbibition\nand permanent sequestration capacity. Fluid imbibition-flowback and\nnuclear magnetic resonance experiments are conducted to check the\nmicroscopic reliability: once being imbibed into shale, only less\nthan 20% of the total fluid is driven out even under a pressure gradient\nof 22.1–62.6 MPa/m. Macroscopic flowback data from Longmaxi\nshale gas wells in the Sichuan Basin further demonstrates that by\nadding 10–30 days to current shut-in operations the flowback\nrates of a HF fluid decrease approximately 5–15%, meaning a\nreduction of 2000–6000 m<sup>3</sup> wastewater per single\nwell without extra technical procedures or additives. Moreover, fractured\nsample displacement experiments, simulations, and field data statistics\nconfirm that extending shut-in time causes an overall improvement\nin well productivity and flowback fluid quality.
Review: Roles for astrocytes in epilepsy: insights from malformations of cortical development

Field: Neuroscience (Life Sciences)

Malformations of cortical development ( MCD s), such as cortical dysplasia and tuberous sclerosis complex, are common causes of intractable epilepsy, especially in paediatric patients. Recently, mounting evidence points to a common pathology of these disorders. Hyperactivation of mammalian target of rapamycin ( mTOR ) has been proposed as a central mechanism in most, if not all, MCD s. The transition from mTOR hyperactivation and cellular abnormalities to large‐scale functional changes and seizure is, however, not fully understood. In this article we set out to review currently available information regarding MCD pathology, focusing on glial cells – especially astrocytes – and their interactions with the brain vascular system. A large body of evidence points to these elements as potential targets in MCD . Here, we attempt to provide a review of this evidence and propose some hypotheses regarding the possible chain of events linking primary glial dysfunction and epilepsy. We focus on extracellular matrix remodelling, blood–brain barrier leakage and failure of astrocyte‐dependent removal of extracellular debris. We posit that the failure of these systems results in a chronically pro‐inflammatory environment, maintaining local astrocytes in a state of gliosis, with increased susceptibility to seizures as a consequence.
Breaking Hyperbolicity for Smooth Symplectic

Field: Mathematics (Physical Sciences)

We study a smooth symplectic 2-parameter unfolding of an almost hyperbolic diffeomorphism on two-dimensional torus. This diffeomorphism has a fixed point of the type of the degenerate saddle. In the parameter plane there is a bifurcation curve corresponding to the transition from the degenerate saddle into a saddle and parabolic fixed point, separatrices of these latter points form a channel on the torus. We prove that a saddle period-2 point exists for all parameter values close to the co-dimension two point whose separatrices intersect transversely the boundary curves of the channel that implies the existence of a quadratic homoclinic tangency for this period-2 point which occurs along a sequence of parameter values accumulating at the co-dimension 2 point. This leads to the break of stable/unstable foliations existing for almost hyperbolic diffeomorphism. Using the results of Franks (1) on π1- diffeomorphisms, we discuss the possibility to get an invariant Cantor set of a positive measure being non-uniformly hyperbolic.
Regio- and Stereoselective Synthesis of Multi-Alkylated Allylic Boronates through Three-Component Coupling Reactions between Allenes, Alkyl Halides, and a Diboron Reagent

Field: Chemistry (Physical Sciences)

Multisubstituted allylic boronates are attractive and valuable precursors for the rapid and stereoselective construction of densely substituted carbon skeletons. Herein, we report the first synthetic approach for differentially 2,3,3-trialkyl-substituted allylic boronates that contain a stereodefined tetrasubstituted alkene structure. Copper(I)-catalyzed regio- and stereoselective three-component coupling reactions between gem-dialkylallenes, alkyl halides, and a diboron reagent afforded sterically congested allylic boronates. The allylboration of aldehydes diastereoselectively furnished the corresponding homoallylic alcohols that bear a quaternary carbon. A computational study revealed that the selectivity-determining mechanism was correlated to the coordination of a boryl copper(I) species to the allene substrate as well as the borylcupration step.