jimnoneill/paper-to-field-training huggingface dataset:
Molecular and Morphologic Correlates of the Alternative Lengthening of Telomeres Phenotype in High‐Grade Astrocytomas

Field: Medicine (Health Sciences)

Abstract Recent studies suggest that the telomere maintenance mechanism known as alternative lengthening of telomeres ( ALT ) is relatively more common in specific glioma subsets and strongly associated with ATRX mutations. We retrospectively examined 116 high‐grade astrocytomas (32 pediatric glioblastomas, 65 adult glioblastomas, 19 anaplastic astrocytomas) with known ALT status using tissue microarrays to identify associations with molecular and phenotypic features. Immunohistochemistry was performed using antibodies against ATRX , DAXX , p53 and IDH1 R132H mutant protein. EGFR amplification was evaluated by fluorescence in situ hybridization ( FISH ). Almost half of fibrillary and gemistocytic astrocytomas (44%) demonstrated ALT . Conversely all gliosarcomas (n = 4), epithelioid (n = 2), giant cell (n = 2) and adult small cell astrocytomas (n = 7) were ALT negative. The ALT phenotype was positively correlated with the presence of round cells ( P = 0.002), microcysts ( P < 0.0002), IDH1 mutant protein ( P < 0.0001), ATRX protein loss ( P < 0.0001), strong P53 immunostaining ( P < 0.0001) and absence of EGFR amplification ( P = 0.004). There was no significant correlation with DAXX expression. We conclude that ALT represents a specific phenotype in high‐grade astrocytomas with distinctive pathologic and molecular features. Future studies are required to clarify the clinical and biological significance of ALT in high‐grade astrocytomas.
Desferrioxamine and Acute Iron Poisoning

Field: Medicine (Health Sciences)

Background: Left ventricular non-compaction (LVNC) may manifest an undulating phenotype ranging from dilated to hypertrophic appearance. It is unknown whether tissue Doppler (TD) velocities can predict adverse clinical outcomes including death and need for transplantation in children with LVNC. Methods and results: 56 children (median age 4.5 years, median follow-up 26 months) with LVNC evaluated at one hospital from January 1999 to May 2004 were compared with 56 age/sex-matched controls. Children with LVNC had significantly decreased early diastolic TD velocities (Ea) at the lateral mitral (11.0 vs 17.0 cm/s) and septal (8.9 vs 11.0 cm/s) annuli compared with normal controls (p<0.001 for each comparison). Using receiver operator characteristic curves, the lateral mitral Ea velocity proved the most sensitive and specific predictor for meeting the primary end point (PEP) at 1 year after diagnosis (area under the curve = 0.888, SE = 0.048, 95% CI 0.775 to 0.956). A lateral mitral Ea cut-off velocity of 7.8 cm/s had a sensitivity of 87% and a specificity of 79% for the PEP. Freedom from death or transplantation was 85% at 1 year and 77% at 2 years. Conclusions: TD velocities are significantly reduced in patients with LVNC compared with normal controls. Reduced lateral mitral Ea velocity helps predict children with LVNC who are at risk of adverse clinical outcomes including death and need for cardiac transplantation.
PENGARUH PROGRAM PERSONAL SELLING TERHADAP KEPUTUSAN PEMBELIAN MEETING PACKAGE DI ASTON BRAGA HOTEL AND RESIDENCE

Field: Business, Management and Accounting (Social Sciences)

Aston Braga Hotel and Residence adalah salah satu hotel di kota Bandung yang memiliki fasilitas meeting room dan menjualnya melalui meeting package. Keputusan pembelian meeting package Aston Braga dapat dipengaruhi oleh beberapa hal salah satunya adalah melalui promosi personal selling. Personal selling merupakan salah satu strategi promosi yang dilakukan Aston Braga hotel and Residence untuk mempengaruhi keputusan pembelian dari tamu bisnis yang membeli meeting package. Berdasarkan hal tersebut maka dilakukan penelitian mengenai seberapa berpengaruhnya promosi personal selling meeting package dalam mempengaruhi keputusan pembelian tamu bisnis di Aston Braga Hotel and Residence. \nJenis penelitian dalam penelitian ini adalah deskriptif verifikatif dan metode penelitian yang digunakan adalah explanatory survey. Teknik analisis data yang digunakan adalah analisis regresi linier sederhana dengan menggunakan program SPSS ver. 20 untuk membantu perhitungan. \nDari hasil penelitian ini diketahui bahwa personal selling meeting package dan keputusan pembelian tamu bisnis di Aston Braga Hotel and Residence secara keseluruhan dinilai telah baik. Kemudian personal selling meeting package memiliki pengaruh yang positif dan pengaruh yang sedang terhadap keputusan pembelian tamu bisnis di Aston Braga Hotel and Residence yaitu sebesar 52,9% sedangkan sisanya sebesar 47,1% merupakan pengaruh dari variabel lainnya yang tidak diteliti. \nKata Kunci : Personal Selling, Keputusan Pembelian \nNowadays, the development of tourism sector in Bandung is increasing significantly, especially in MICE area. This has made many hotels in Bandung provide meeting room facility. One of those many hotels that provide such facility is Aston Braga Hotel and Residence. Aston Braga Hotel and Residence offers a certain meeting package which is different from its competitors as well as doing personal selling as their promotional strategy in order to influence the buyer’s decision to purchase their product. Therefore, this study tries to investigate how personal selling meeting package offered by Aston Braga Hotel and Residence influences the buyer’s purchase decision. \nThis study is descriptive verification in nature. Explanatory survey is used as the methodology in this research. The technique used in data analysis is simple linier regression analysis using SPSS ver. 20 program to ease the calculation of the data. \nThe result shows that personal selling meeting package and the buyer’s decision to purchase Aston Braga Hotel and Residence’ product overall has been good. In addition, the data shows that personal selling meeting package influences the buyer’s decision to purchase the product by 52,9% and it is considered as a positive and medium effect. Meanwhile, the remaining 47,1% is the influence of other variables that is not analyzed. \nKeywords: Personal Selling, Purchase Decision
Characterisation of coalmining area-specific house dust mite bio-allergens in the environment of Jharia coaldields

Field: Environmental Science (Physical Sciences)

Atmospheric bio-particulates - alone, and adsorbed on the fine coal dust particles, constitute the airspora of the coalfield region and after coming in contactwith human beings, produce various allergicmanifestations. Different kinds of bio-allergens e.g. pollen grains, fungi, algae, and house dust mites(HDMs), prevalent in coalfield environments, being atypically of different compositions and varying concentrations, are not yet properly identified and investigated upon. The coal mining area-specific house dust mites prevalent in the environments of Jharia coalfields have been characterized and reported in the present paper.While 10 coalfield-specific fieldand house dust mites have been definitively identified in the present study, 3 more unidentified mite species too were found , which are also concomitantly prevalent in Jharia coalfields. Of the 3 unidentified HDMs, one is suspected to beMagnenia sps. The identified HDMs include:. Acarus sps., Austroglycyphagus orientalis, Blomia sps., Cheyletus eruditus, Cheyletus sps., Caloglyphus oudemansi, Dermayssus gallinae, Dermatophagoides farinae, Dermatophagoides pterinyssinus, Goheria fusca, Magnenia sps. All these HDM bio-allergens, being octopod anthropodes of arachinda group and inhalant type, are potential allergens, responsible for causing allergic health hazards manifested by different skin, respiratory and other allergic disorders in humans living in and around coal-mining and coalbased industriesÂÂ areas. The concentration of the HDMs was found to be maximum during the rainy season. These inhalant mites are potent allergens, responsible for causing hazardous allergic ailments like bronchial asthma, allergic rhinitis, eczema, and other skin diseases.
The European Public Prosecutor’s Office and the Principle of Equality

Field: Social Sciences (Social Sciences)

The article examines how the principle of equality must be safeguarded in proceedings of the forthcoming European Public Prosecutor’s Office (EPPO). Falletti identifies two main challenges: ensuring equal rights for suspects and ensuring equal handling of cases. Since the EPPO applies both its Regulation and national criminal procedure, differences in procedural safeguards across Member States risk undermining equality, particularly in access to lawyers and defence costs in cross-border cases. On case allocation, fears of forum shopping are addressed by mandatory criteria and oversight by Permanent Chambers, with national courts retaining judicial review. While the system relies heavily on national law and courts, ongoing harmonisation through EU directives and ECJ control should mitigate inequalities. The EPPO’s effectiveness will ultimately depend on practice in balancing European coordination with equal treatment of suspects.
Supplementary Figure Legend from Diverse Targets of β-Catenin during the Epithelial–Mesenchymal Transition Define Cancer Stem Cells and Predict Disease Relapse

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Supplementary Figure Legend from Diverse Targets of β-Catenin during the Epithelial–Mesenchymal Transition Define Cancer Stem Cells and Predict Disease Relapse
Beyond the consultation and the medication: collective activities and resocialization in a CAPS I

Field: Health Professions (Health Sciences)

ABSTRACT Objective: to evaluate the collective and resocialization activities developed in a CAPS I, from the perspective of users, family members and service professionals. Method: evaluative research, anchored in the theoretical-methodological framework of the Fourth Generation Evaluation, conducted with 11 users, six family members and 10 professionals from a Psychosocial Care Center I. It took place from September 2021 to August 2022, using prior ethnography, interviews and negotiation, with data analysis using the Constant Comparative Method. Results: participants pointed out that therapeutic workshops, support groups and collective meetings are held, which take place mainly in the physical space of the service, with adequate operationalization and frequency, facilitated by the professionals’ attitude and the provision of transportation and food. It was assessed that these actions had an impact on the psychosocial care offered, resulting in treatment adherence, improved interpersonal relationships within the service and community, emergence of positive feelings, social inclusion and support for coping with difficulties. The challenges are the support group schedule and the participation of children and adolescents. Final considerations: collective and resocialization activities were evaluated as essential for the psychosocial care offered at CAPS, providing significant benefits to users, promoting interaction, social inclusion, interpersonal relationships and coping with adversities.
OsGGC2, Gγ Subunit of Heterotrimeric G Protein, Regulates Plant Height by Functionally Overlapping with DEP1 in Rice

Field: Agricultural and Biological Sciences (Life Sciences)

Plant heterotrimeric G proteins have been shown to regulate the size of various organs. There are three types of Gγ subunits in plants: type A, consisting of a canonical Gγ domain; type B, possessing a plant-specific domain at the N-terminus of the Gγ domain; and type C, possessing a plant-specific domain at the C-terminal of the Gγ domain. There is one type A, one type B, and three type C of the five γ-subunits in the rice genome. In type C Gγ subunits, GS3, which controls grain size; DEP1, which controls plant height and panicle branching; and their homolog OsGGC2, which affects grain size, have been reported; however, the function of each gene, their interactions, and molecular mechanisms for the control of plant height have not yet been clarified. In this study, we generated loss-of-function mutants of DEP1 and OsGGC2, which have high homology and similar expression, and investigated their phenotypes. Since both dep1 and osggc2 mutants were dwarfed and the double mutants showed a synergistic phenotype, we concluded that both DEP1 and OsGGC2 are positive regulators of plant height and that their functions are redundant.
Learning to weave; weaving to learn ... what?

Field: Social Sciences (Social Sciences)

This paper places the anthropology of learning in conversation with the anthropology of work by unpacking the interrelationship between the processes by which a skill is learned and knowledge about the skill, its possibilities and ramifications. The paper's ethnographic focus is the Labbai mat‐weavers of Pattamadai town in South India, who are ambivalent about being weavers. It contrasts this ambivalence with the excitement that weaving generated in a development practitioner who sought to promote the weaving industry and who also learned how to weave. The same skill is approached differently by different kinds of persons: they understand and learn different things. Learning and knowing cannot be easily separated. By focusing on the various purposes and modes of learning, on the social production of knowledge, and on instances of communication and miscommunication, the paper explores the embodied and historicized production of knowledge by different kinds of person: the mat‐weavers, the development professional, and, to a certain extent, an anthropologist. Résumé Le présent article confronte l’anthropologie de l’apprentissage à l’anthropologie du travail en révélant les relations entre les processus d’acquisition d’une compétence et la connaissance de cette compétence, de ses possibilités et de ses ramifications. Le sujet ethnographique de l’article concerne les tisserands de tapis Labbai de la ville de Pattamadai, dans le Sud de l’Inde, qui ont une attitude ambivalente vis‐à‐vis de leur statut de tisserands. L’auteur met en regard cette ambivalence et l’intérêt éveillé par le tissage chez un intervenant en développement qui cherchait à promouvoir l’artisanat du tissage et avait même appris à tisser. La même compétence est approchée différemment par différentes sortes de personnes : celles‐ci voient et comprennent des choses différentes. L’apprentissage et la connaissance ne peuvent pas être facilement dissociés. En se concentrant sur les différents buts et modes de l’apprentissage, sur la production sociale de connaissance et sur des cas de communication bien et mal menée, l’article explore la production incorporée et historicisée de connaissances par différentes sortes de personnes : les tisserands, le professionnel du développement et, dans une certaine mesure, l’anthropologue.
VEHICLE DESIGN OPTIMIZATION SYSTEM USER MANUAL

Field: Engineering (Physical Sciences)

The Vehicle Design Optimization System (VDOS) is a group of four computer programs developed to study the effects of vehicle exterior designs on pedestrian fatalities and injuries. The four programs are OPTREG (optimization and regression analysis), PROMETHEUS 2 (accident simulation), ENTRACT (an interface program between OPTREG and PROMETHEUS 2, which converts the parametric hood model utilized by OPTREG to the finite element hood required by PROMETHEUS 2), and PRMPLT (an interface program between PROMETHEUS 2 and OPTREG which combines the detailed accident simulation measurements into a single number called a pedestrian injury index, and also generates Stromberg Carlson 4020 plots of the accident data). This document describes the coordinated use of OPTREG, PROMETHEUS 2, ENTRACT and PRMPLT to study hood design. Usage instructions for ENTRACT and PRMPLT are given, including data preparation instructions and examples of CDC 6600 KRONOS Interactive Timesharing control card sequences for execution of the programs. The relationship between the programs is described and all files used by the system are described in detail.
SUB-DOPPLER OPTOTHERMAL SPECTROSCOPY AND INTRAMOLECULAR DYNAMICS OF THE $\nu_{1}$ AND 2$\nu_{1}$ BANDS IN $SF_{5}CCH$

Field: Chemistry (Physical Sciences)

Author Institution: Laboratorio Europeo di Spettoscopie Non-lineari (LENS); Department of Chemistry, Princeton University; Department of Chemistry, Portland State University
Design of a cavity backed 15:1 bandwidth two arm spiral helix antenna

Field: Engineering (Physical Sciences)

A design of a 15:1 bandwidth single-mode two-arm spiral helix antenna is presented. In order to achieve unidirectional and efficient radiation, the spiral is cavity backed and resistively loaded. A trapezoidal pyramid cavity is implemented for higher gain at the turn on frequency and smoother gain variation at higher frequencies. Numerical simulations are conducted to assess the gain and axial ratio of the spiral helix for different trapezoidal pyramid heights and diameters. By choosing proper cavity parameters, a wideband spiral with VSWR <; 2.5, axial ratio <; 4 dB at elevation angle of 30° and gain > 0 dBic at the turn-on frequency are realized.
Self-control and knowledge sharing on Chinese farmers’ credit default: Part-time salary as a moderator

Field: Economics, Econometrics and Finance (Social Sciences)

In China's rural financial market, farmers’ credit default has resulted in a high non-performing loan (NPL) rate and increased financial risk. This work uses structural equation model (SEM) to study the factors of farmers’ credit default. The results show knowledge sharing would be the key factor, while the self-control variable is not significant. Knowledge sharing has three levels of dimensions among farmers. Financial knowledge is ranked in order of importance, followed by market and agricultural technology knowledge. At the same time, part-time job salary has a significant moderate effect between knowledge sharing and credit default. This work innovatively constructs two levels of rationality and emotion to analyze the credit default, and expands the application of behavioral finance in the field of farmer credit. The findings have some inspirations for reducing farmers' credit default risk.
From Cancer to Immune Organoids: Innovative Preclinical Models to Dissect the Crosstalk between Cancer Cells and the Tumor Microenvironment

Field: Medicine (Health Sciences)

Genomic-oriented oncology has improved tumor classification, treatment options, and patient outcomes. However, genetic heterogeneity, tumor cell plasticity, and the ability of cancer cells to hijack the tumor microenvironment (TME) represent a major roadblock for cancer eradication. Recent biotechnological advances in organotypic cell cultures have revolutionized biomedical research, opening new avenues to explore the use of cancer organoids in functional precision oncology, especially when genomics alone is not a determinant. Here, we outline the potential and the limitations of tumor organoids in preclinical and translational studies with a particular focus on lung cancer pathogenesis, highlighting their relevance in predicting therapy response, evaluating treatment toxicity, and designing novel anticancer strategies. Furthermore, we describe innovative organotypic coculture systems to dissect the crosstalk with the TME and to test the efficacy of different immunotherapy approaches, including adoptive cell therapy. Finally, we discuss the potential clinical relevance of microfluidic mini-organ technology, capable of reproducing tumor vasculature and the dynamics of tumor initiation and progression, as well as immunomodulatory interactions among tumor organoids, cancer-associated fibroblasts (CAFs) and immune cells, paving the way for next-generation immune precision oncology.
Directional selection against different life histories in the Arctic lamprey (Lethenteron camtschaticum): identification by microsatellite analysis

Field: Agricultural and Biological Sciences (Life Sciences)

To understand the selective forces promoting life history evolution in lampreys, footprints of natural selection were identified using the hitchhiking mapping approach for microsatellite loci. To achieve the objective, the Arctic lamprey (Lethenteron camtschaticum), including anadromous and recently derived landlocked-fluvial populations, were targeted. Seven microsatellites were genotyped and subjected to population genetic analyses and outlier tests. The results indicated that a significant signature of directional selection could be detected in one microsatellite locus (Lspn013). Discrepancies in allelic frequencies of Lspn013 were remarkable between anadromous and landlocked-fluvial populations, leading to high population genetic divergence between them. Based on a homology search, Lspn013 was estimated to be located near the vasotocin precursor gene, which plays an important role in osmoregulation. Life history differences in lampreys have resulted from habitat difference in adult phase, which have probably led to recent natural selection on the gene responsible for osmoregulatory functions.
Hemoglobin Oxidation in Stored Blood Accelerates Hemolysis and Oxidative Injury to Red Blood Cells

Field: Medicine (Health Sciences)

Abstract Introduction Maintaining blood supply is a challenge in blood banks. Red blood cells (RBCs) stored at 4°C experience issues of biochemical changes due to metabolism of cells, leading to changes collectively referred to as “storage lesions.” Oxidation of the red cell membrane, leading to lysis, contributes to these storage lesions. Methods Blood bags with CPD-SAGM stored at 4°C for 28 days were withdrawn aseptically on days 1, 14, and 28. Hematology analyzer was used to investigate RBC indices. Hemoglobin oxidation was studied through spectrophotometric scan of spectral change. RBC lysis was studied with the help of Drabkin's assay, and morphological changes were observed by light and scan electron microscopy. Results RBCs show progressive changes in morphology echinocytes and spherocytes on day 28. There was 0.85% RBC lysis, an approximately 20% decrease in percentage oxyhemoglobin, and a 14% increase in methemoglobin formation, which shows hemoglobin oxidation on day 28. Conclusions Oxidative damage to RBC, with an increase in storage time was observed in the present study. The observed morphological changes to RBC during the course of increased time shows that there is progressive damage to RBC membrane and a decrease in hemoglobin concentration; percentage RBC lysis is probably due to free hemoglobin and iron.