jimnoneill/paper-to-field-training huggingface dataset:
Pricing and Upgrade Strategies for Software Vendors in the Software-as-a-Service Market

Field: Economics, Econometrics and Finance (Social Sciences)

This study examines the competition between an independent software vendor (ISV) who offers a standard fixed-price software product and a cloud software vendor (CSV) who adopts a usage-based linear pricing scheme for its cloud-based software. Using a game theoretic approach, we set up a duopoly model to derive the optimal pricing and product feature choice decisions for both the ISV and the CSV in a market characterized with heterogeneous consumer preferences for software features, and different risk structures. Next, we plan to extend the duopoly model into a two-stage game and examine how the equilibrium outcomes change when we allow both vendors to exercise their software upgrade strategies. The results of our study will provide important implications to vendors and consumers in software markets where the Software-as-aService (SaaS) business model began to prevail and contribute to the growing literature on economics of cloud computing.
STRUCTURED EXERCISE IMPROVES FATIGUE AND HEALTH-RELATED QUALITY OF LIFE IN METASTATIC BREAST CANCER PATIENTS: THE MULTINATIONAL RANDOMIZED CONTROLLED PREFERABLE-EFFECT STUDY

Field: Medicine (Health Sciences)

INTRODUCTION & AIMS Exercise has been proven safe and effective for patients with breast cancer in the curative setting, however evidence in patients with metastatic breast cancer (mBC) is scarce. The aim of the PREFERABLE - EFFECT study (NCT04120298) was to evaluate the effects of a structured exercise program on fatigue, health-related quality of life (HRQoL), and other cancer- and treatment-related side effects in patients with mBC. METHODS The randomized controlled trial included patients with mBC from five European countries (Germany, Spain, Netherlands, Poland, Sweden) and Australia. Participants were randomly assigned to usual care (UC) or a 9-month supervised and individualized exercise program (EX) involving twice weekly aerobic, resistance, and balance exercises. The primary outcomes, physical fatigue (EORTC QLQ-FA12 subscale) and HRQoL (EORTC QLQ-C30 summary score) were assessed at baseline, 3, 6, and 9 months. Among other physical fitness outcomes, maximal short exercise capacity was assessed with the Steep Ramp Test. Changes from baseline to 3, 6 (primary endpoint) and 9 months were compared between groups using adjusted mixed models for repeated measures. RESULTS A total of 357 patients were randomized (EX=178, UC=179). On average, participants were 55.4 years of age (SD=11.1) and 73.9% had bone metastases. EX resulted in a significant reduction in physical fatigue (-5.3 [-10.0; -0.6], p=.027, ES=0.22) and improvement in HRQoL (+4.8 [2.2; 7.4], p=.0003, ES=0.33) compared to UC at 6 months (primary endpoint), as well as at 3 and 9 months. EX also improved physical fitness (+24.3 Watts, [15.5; 33.1], ES=0.42, at 6 months) and numerous relevant QLQ-C30 scales, including social functioning, pain, and dyspnoea. CONCLUSION This large multinational study demonstrates that supervised exercise improves fatigue, HRQoL, and other clinically relevant outcomes in patients with mBC. Based on these findings, supervised exercise should be recommended to patients with mBC.
ANTIDIARRHEAL ACTIVITY OF ETANOLIC EXTRACT OF BAY LEAVES (SYZYGIUM POLYANTHUM [WIGHT.] WALP.)

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Indonesia people have been used of Bay Leaves (S. polyanthum [Wight.]Walp.) to treat of antidiarrhea, cholesterol, hypertension, gastritis, and diabetes mellitus.Extrac of Bay Leaves can be inhibit growth of Escherichia coli, Vibrio Cholera, and Salmonella sp.It's the bacterium that produce an entherotoxin so as to cause diarrhoea.Bioassay of antidiarrheal activity by using transit intestinal method and mice (Mus musculus) as an animal model induced by castor oil.The mice were grouped into five groups.Group I is received Na-CMC as control, group II, III, and IV are received of Ethanolic Extract of Bay Leaves (EEBL) with concentration 10%, 20%, and 30%, respectively and group V as positive control by received Loperamide-HCl.The charcoal used to marker as indicators.The result of the test indicate that EEBL have antidiarrheal activity to animal model.Refers to analysis of variant p=0.05, showing that concentration 30% has an activity non significant with loperamide-HCl as positive control.
Correction to Modifying Self-Assembled Peptide Cages To Control Internalization into Mammalian Cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Modifying Self-Assembled Peptide Cages To Control Internalization into Mammalian CellsJoseph L. BeesleyJoseph L. BeesleyMore by Joseph L. Beesleyhttp://orcid.org/0000-0003-2203-0027, Holly E. BaumHolly E. BaumMore by Holly E. Baum, Lorna R. HodgsonLorna R. HodgsonMore by Lorna R. Hodgson, Paul VerkadePaul VerkadeMore by Paul Verkade, George S. Banting*George S. BantingMore by George S. Banting, and Derek N. Woolfson*Derek N. WoolfsonMore by Derek N. Woolfsonhttp://orcid.org/0000-0002-0394-3202Cite this: Nano Lett. 2019, 19, 5, 3386Publication Date (Web):April 11, 2019Publication History Published online11 April 2019Published inissue 8 May 2019https://pubs.acs.org/doi/10.1021/acs.nanolett.9b01133https://doi.org/10.1021/acs.nanolett.9b01133correctionACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1260Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (207 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Screening of the starter cultures of weak postacidification in yoghourt

Field: Agricultural and Biological Sciences (Life Sciences)

Postacidification always occurred in yogurt during the storage, transportation, sale and eating leads,which resulted in short storage time for yogurt. The short shelf life of yogurt interferes with its consume. There are many measures of controlling postacidification in yogurt, the best of which is that strains producing both strong acid at high temperature and little acid at low temperature selected as starter cultures. Based on the previous studies, several potential starter cultures were studied in this paper. It was found that the yogurt fermented by the YF-L812 starter culture from Hansen corporation produced a little postacidification, and its acidity rose only 14.5 °T after 30 days at 6 ℃.
Effect of Different Catheter Material Against Formation of Escherichia coli Biofilm

Field: Medicine (Health Sciences)

OBJECTIVE To investigate the effect of different catheter material against formation of Escherichia coli biofilm. METHODS E.coli biofilms were prepared with three kinds of catheters,which were made of latex,siliconized-latex and total silicone,incubated with E.coli for 7 days,the viable bacteria counts of biofilm were performed by serially diluted method and the biofilm morphology was observed by scanning electron microscope. RESULTS The viable bacterial counts of biofilm adhered to latex and siliconized latex were 6.74×10~5 CFU/cm~2 and 3.72×10~5CFU/cm~2,respectively,compared with 6.98×10~3 CFU/cm~2 of biofilm adhered to total silicone,statistical significant difference consisted in the counts of biofilm adhered to three kinds of materials(P0.01). On the three catheter material surface there were coated with matrix by scanning electron microscopy,a great deal of bacteria adhered the fibrin matrix and clusters of bacteria cells were seen,but there were only a great of bacteria adhered to the total silicone local surface. CONCLUSIONS In three catheter materials the bacterial biofilm is not easily formed on the total silicone,we should choose the total silicone catheter for the patient who needed the long term indwelling catheter.
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Numerous studies indicate that Sirtuin 1 (SIRT1), a mammalian nicotinamide adenine dinucleotide (NAD + )-dependent histone deacetylase (HDAC), plays a crucial role in p53-mediated stress responses by deacetylating p53. Nevertheless, the acetylation levels of p53 are dramatically increased upon DNA damage, and it is not well understood how the SIRT1–p53 interaction is regulated during the stress responses. Here, we identified Set7/9 as a unique regulator of SIRT1. SIRT1 interacts with Set7/9 both in vitro and in vivo. In response to DNA damage in human cells, the interaction between Set7/9 and SIRT1 is significantly enhanced and coincident with an increase in p53 acetylation levels. Importantly, the interaction of SIRT1 and p53 is strongly suppressed in the presence of Set7/9. Consequently, SIRT1-mediated deacetylation of p53 is abrogated by Set7/9, and p53-mediated transactivation is increased during the DNA damage response. Of note, whereas SIRT1 can be methylated at multiple sites within its N terminus by Set7/9, a methylation-defective mutant of SIRT1 still retains its ability to inhibit p53 activity. Taken together, our results reveal that Set7/9 is a critical regulator of the SIRT1-p53 interaction and suggest that Set7/9 can modulate p53 function indirectly in addition to acting through a methylation-dependent mechanism.
Mechanically Reconfigurable Pd Nanogroove Array: An Ultrasensitive Optical Hydrogen Detector

Field: Materials Science (Physical Sciences)

Low-cost hydrogen sensors, designed for ultrasensitive, reliable, and rapid identification of hydrogen gas (H2), are extremely desired in almost all hydrogen-related applications in the forthcoming hydrogen economy, including crude oil refinement, hydrogen-fueled vehicles, and molecular hydrogen therapy. Here, we first report on the experimental realization of an ultrasensitive optical hydrogen sensor based on a new type of flexible palladium (Pd) nanogroove array. Each groove can be driven synchronously by absorbed hydrogen, with the assistance of the underneath elastic substrate, to mechanically reconfigure itself and thus amplify the spectral shift of plasmon resonance for hydrogen sensing. Our experimental results show a plasmon resonance with a narrow line width of 74 nm, which has a wavelength shift of 18 nm after exposed to 4% H2 in nitrogen gas (N2). In addition, the extremely high relative reflectance change of 400% was achieved, giving rise to an ultralow H2 (in N2) detection limit of 0.1% and sensing resolution of 0.013% in the low H2 volume concentration regime. Meantime, exposure to H2 causes a rapid and reversible change in reflectance on a time scale of seconds. This pronounced performance suggests that our flexible Pd nanogroove array provides a promising optical hydrogen detection scheme for practical applications.
Global sensitivity analysis and optimization for coal–water slurry preheaters based on metamodel of optimal prognosis

Field: Chemical Engineering (Physical Sciences)

Enhancing energy efficiency by coal–water slurry preheaters in the gasification process, the geometry of ladder-type fold helical baffles and shell–inlet velocity have an important effect on thermo-hydraulic performance of preheaters. A variance-based global sensitivity analysis procedure was built by metamodel of prognosis, and optimization results were compared between genetic algorithm and particle swarm optimization. The simulation results illustrate that heat transfer coefficient per unit pressure drop (K/ΔP) increases when folding angle and folding ratio increase, and K/ΔP decreases with increasing relative height and shell–inlet velocity. As for K/ΔP, the coefficient of prognosis of full model is 99.03%, and total effects of shell–inlet velocity, folding angle, folding ratio and relative height is 70.34%, 25.01%, 8.74%, and 7.87%, respectively. Based on reduced spaces with most influential parameters, optimization cases show genetic algorithm is more efficient and provides better results, folding angle, folding ratio, relative height and shell–inlet velocity are 50°, 0.6, 0.5 and 1.4 m s–1 when maximizing K/ΔP. The research results provide theoretical guidance for selection, design and optimization of coal–water slurry preheaters.
Do Academic Environment and Access to Capital Among University Students Contribute to Entrepreneurial Interest Through Creativity?

Field: Business, Management and Accounting (Social Sciences)

University students, as prospective graduates, play a critical role in generating new employment opportunities through entrepreneurship. This study investigates whether the academic environment and access to capital contribute to entrepreneurial interest among university students, with creativity acting as a mediating variable. A quantitative research design was employed, involving a sample of 100 students selected using proportional random sampling. Data were collected via an online questionnaire and analyzed using SPSS version 27. The findings reveal that the academic environment has a positive and significant influence on both creativity and entrepreneurial interest. Access to capital positively affects creativity but has a negative and significant direct effect on entrepreneurial interest. Creativity, on the other hand, exerts a positive and significant effect on entrepreneurial interest. Moreover, the academic environment significantly contributes to entrepreneurial interest through creativity. Similarly, access to capital indirectly and positively influences entrepreneurial intention when mediated by creativity. These results suggest that fostering a supportive academic environment and enhancing student creativity can significantly boost entrepreneurial aspirations, even when direct financial access is limited or perceived negatively. The study highlights the strategic role of creativity in translating academic and financial inputs into entrepreneurial motivation within higher education contexts.
Relative contributions of emphysema and airway remodelling to airflow limitation in COPD: Consistent results from two cohorts

Field: Medicine (Health Sciences)

Abstract Background and objective The relative contributions of emphysema and airway remodelling to airflow limitation remain unclear in chronic obstructive pulmonary disease ( COPD ). We aimed to evaluate the relative contributions of emphysema and airway wall thickness measured by quantitative computed tomography ( CT ) to the prediction of airflow limitation in two separate COPD cohorts. Methods Pulmonary function tests and whole‐lung CT were performed in 250 male smokers with COPD , including 167 from U niversity M edical C enter at H o C hi M inh C ity, V ietnam, and 83 from S higa U niversity of M edical Science H ospital, J apan. The same CT analysis software was used to measure the percentage of low attenuation volume (% LAV ) at the threshold of −950 H ounsfield units and the square root of wall area of a hypothetical airway with an internal perimeter of 10 mm ( Pi 10). The standardized coefficients in multiple linear regressions were used to evaluate the relative contributions of % LAV and Pi 10 to predictions of FEV 1 / FVC and FEV 1 % predicted. Results Both % LAV and Pi 10 independently predicted either forced expiratory volume in 1 s/forced vital capacity ( FEV 1 / FVC ) or FEV 1 % predicted ( P ≤ 0.001 for all standardized coefficients). However, the absolute values of the standardized coefficients were 2−3 times higher for % LAV than for Pi 10 in all prediction models. The results were consistent in the two COPD cohorts. Conclusions % LAV predicts both FEV 1 / FVC and FEV 1 better than Pi 10 in patients with COPD . Thus, emphysema may make a greater contribution to airflow limitation than airway remodelling in COPD .
Analysis of experimental data sets for local scour depth around bridge abutments using artificial neural networks

Field: Engineering (Physical Sciences)

The performance of soft computing techniques to analyse and interpret the experimental data of local scour depth around bridge abutment, measured at different laboratory conditions and environment, is presented. The scour around bridge piers and abutments is, in the majority of cases, the main reason for bridge failures. Therefore, many experimental and theoretical studies have been conducted on this topic. This study sought to answer the following questions: Firstly, can data collected by different researchers at different times be combined in one data set? Secondly, can we determine any unquantified effects such as data differences, laboratory conditions and measurement devices? Artificial neural networks (ANN) are used and a basic ANN model is selected to observe the application problems, in order to avoid any misleading conclusion arising due to the model parameters selected and the compilation of different subsets of experimental data into one set. At the first stage, seven experimental data sets are compiled to address the first question and an ANN model is used to discovery any existing discrepancies between available data groups. The importance of selected model parameters for the model’s performance was demonstrated by increasing the number of parameters. Then, each data subset was inspected to expose the importance of the homogeneity of data groups in order to obtain a best-fit ANN model. Finally, a sensitivity analysis was carried out to obtain the dominant parameters of the problem. It was concluded that the use of ‘soft ’ computational techniques such as ANN can be beneficial, provided the user is aware of the heterogeneity of the data set and the physical context of the subject
Matrix Models and Geometry of Moduli Spaces

Field: Mathematics (Physical Sciences)

We give the description of discretized moduli spaces (d.m.s.) $\Mcdisc$ introduced in \cite{Ch1} in terms of discrete de Rham cohomologies for moduli spaces $\Mgn$. The generating function for intersection indices (cohomological classes) of d.m.s. is found. Classes of highest degree coincide with the ones for the continuum moduli space $\Mc$. To show it we use a matrix model technique. The Kontsevich matrix model is the generating function in the continuum case, and the matrix model with the potential $Nα\tr {\bigl(- \fr 14 ŁXŁX -\fr12\log (1-X)-\fr12X\bigr)}$ is the one for d.m.s. In the latest case the effects of Deligne--Mumford reductions become relevant, and we use the stratification procedure in order to express integrals over open spaces $\Mdisc$ in terms of intersection indices, which are to be calculated on compactified spaces $\Mcdisc$. We find and solve constraint equations on partition function $\cal Z$ of our matrix model expressed in times for d.m.s.: $t^\pm_m=\tr \fr{\d^m}{\dł^m}\fr1{\e^ł-1}$. It appears that $\cal Z$ depends only on even times and ${\cal Z}[t^\pm_\cdot]=C(åN) \e^{\cal A}\e^{F(\{t^{-}_{2n}\}) +F(\{-t^{+}_{2n}\})}$, where $F(\{t^\pm_{2n}\})$ is a logarithm of the partition function of the Kontsevich model, $\cal A$ being a quadratic differential operator in $\dd{t^\pm_{2n}}$.
A self-equalization band pass filter having arbitrary complex transmission zeros

Field: Engineering (Physical Sciences)

A self-equalization band pass filter having complex transmission zeros is realized in the form of a Foster type network. Complex transmission zeros enable self-equalization to flatten magnitude and group delay times simultaneously in the same bandwidth while maintaining high selectivity by associated attenuation poles. Only a Foster type network has adequate capability to embody such characteristics involving arbitrary transmission zeros. In addition, the Foster type network has another unique capability to allow a new "term by term" frequency transform. This frequency transform enables the suppression of an undesired slope in the group delay times. This slope is inevitably produced when the conventional frequency transform is applied. As a design example, a self-equalization band pass filter applied to a 9/sup th/ order Bessel filter is shown.
Reproducible noise discrimination with concurrent narrowband noises

Field: Neuroscience (Life Sciences)

Reproducible noise discrimination ability was measured with a cued 2IFC procedure. Stimuli were either one, two, or three concurrent noise bands with bandwidths of either 12.5, 50, or 200 Hz and center frequencies of either 500, 1250, or 3125 Hz. In the multiband conditions, the concurrent noise samples either shared a common bandwidth and a common pattern of envelope fluctuation, had a common bandwidth with asynchronous envelopes, or had different bandwidths. Performance in the single versus multiband conditions was used to estimate cross-spectral correlations in the integration of envelope information. Single-band d′’s were inversely related to both bandwidth and center frequency. Performance in the multiband conditions was generally better than with the component bands presented individually. For subjects whose single-band d′’s were widely separated, greatest integration was obtained in the synchronous multiband conditions. Correlation estimates were significantly higher in the synchronous versus the two asynchronous condition sets. In all conditions, estimated correlation was inversely related to bandwidth. Results are used to model internal noise levels in cross-spectral envelope processing. [Work supported by NIH.]
[Apoptosis and myopathies].

Field: Medicine (Health Sciences)

Recently a new type of cell death, apoptosis, was reported in the biological and many other fields. In an attempt to determine whether the Fas-Fas-ligand mediated apoptosis operates in the pathologic process of human myopathies, we examined the expression of Fas antigen, the synthesis of Fas-ligand mRNA, and the presence of chromosomal DNA fragmentation in the muscles from patients with various human muscle disorders. The Fas antigen of a whole molecule that can transduces the apoptotic signal into the cytoplasm was expressed on the muscle fibers of patients with various muscle wasting diseases. Its expression on muscle fibers was not disease specific, and the frequency of it becomes high according to the extent of the alteration of the muscle pathology. However, there was no evidence of operating the apoptotic process, that is no DNA fragmentation by TUNEL method. Furthermore, no Fas-ligand synthesis was detected in the diseased muscle tissue by RT-PCR method. Our data suggest that the expression of Fas antigen on muscle fibers in diseased muscles might be related to unknown biological functions other than "apoptosis" in the process of muscle fiber injury.