jimnoneill/paper-to-field-training huggingface dataset:
Maternal Deworming Research Study (MADRES) protocol: a double-blind, placebo-controlled randomised trial to determine the effectiveness of deworming in the immediate postpartum period

Field: Medicine (Health Sciences)

Introduction Soil-transmitted helminth infections are endemic in 114 countries worldwide, and cause the highest burden of disease among all neglected tropical diseases. The WHO includes women of reproductive age as a high-risk group for infection. The primary consequence of infection in this population is anaemia. During lactation, anaemia may contribute to reduced quality and quantity of milk, decreasing the duration of exclusive breastfeeding and lowering the age at weaning. To date, no study has investigated the effects of maternal postpartum deworming on infant or maternal health outcomes. Methods and analysis A single-centre, parallel, double-blind, randomised, placebo-controlled trial will be carried out in Iquitos, Peru, to assess the effectiveness of integrating single-dose 400 mg albendazole into routine maternal postpartum care. A total of 1010 mother-infant pairs will be randomised to either the intervention or control arm, following inhospital delivery and prior to discharge. Participants will be visited in their homes at 1, 6, 12 and 24 months following delivery for outcome ascertainment. The primary outcome is infant mean weight gain between birth and 6 months of age. Secondary outcomes include other infant growth indicators and morbidity, maternal soil-transmitted helminth infection and intensity, anaemia, fatigue, and breastfeeding practices. All statistical analyses will be performed on an intention-to-treat basis. Ethics and dissemination Research ethics board approval has been obtained from the McGill University Health Centre (Canada), the Asociación Civil Impacta Salud y Educación (Peru) and the Instituto Nacional de Salud (Peru). A data safety and monitoring committee is in place to oversee study progression and evaluate adverse events. The results of the analyses will be published in peer-reviewed journals, and presented at national and international conferences. Trial registration number Clinicaltrials.gov: NCT01748929 .
Radiographer’s expectations for role development: a survey in the perspective of Norwegian radiography students

Field: Health Professions (Health Sciences)

Poster: ECR 2016 / B-0150 / Radiographer’s expectations for role development: a survey in the perspective of Norwegian radiography students by: A. Tavares, A. F. Abrantes, L. P. V. Ribeiro, R. P. P. Almeida, J. P. Pinheiro, K. B. Azevedo, S. Rodrigues; Faro/PT
Forex exchange using big data analytics

Field: Computer Science (Physical Sciences)

Abstract Analysis and Prediction of forex has gained immense value in today’s economy. The stock price prediction is a difficult process owing to the irregularities in stock prices. Every trader wants to know if the pattern has been repeated in past to know what the possible output of the current situation will be. The primary objective is to propose a methodology that will use a historical dataset and provide a more accurate prediction on stock price. In this paper, we will be using machine learning pattern recognition algorithm on forex tick dataset. The learned model then will produce pattern from the given dataset and on the pattern of increasing or decreasing, the buyer will initiate a buy or sell the stock respectively. We will use python coding to execute the algorithm in jupyter notebook. Matplot library will help us to perform graphing in the process and Numpy will be helpful in doing statistical analysis of data.
Abstract B224: HPV-stratified analysis of prognostic role of miR-21 in oropharyngeal squamous cell carcinoma.

Field: Medicine (Health Sciences)

Abstract Background: Both smoking and human papillomavirus (HPV) infection play an significant role in the development and progression of oropharyngeal squamous cell carcinoma (OSCC). MicroRNAs are short noncoding RNAs that regulate multiple mRNAs and are frequently dysregulated in cancer. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally related to cellular proliferation and apoptosis. In this study, we investigated the association between the expression of miR-21 and the clinicopathologic features by stratified analysis based on HPV infection status. Patients and Methods: The expression of miR-21 in the OSCC tissues of 137 patients was evaluated by in situ hybridization method. In addition, PDCD4 and PTEN were also examined by immunohistochemistry using tissue microarray. The clinicopathological implications of these molecules were analyzed statistically. Results: The up-regulation of miR-21 expression was 22.7% for HPV negative group and 42.1% for HPV positive group (P = 0.081), and significantly correlated with advanced lymph node metastasis and extracapsular extension (P = 0.005 and P = 0.014, respectively). There was a significant association between miR-21 and cytoplasmic PDCD4 overexpression (P = 0.027). Kaplan-Meier analysis showed that up-regulation of miR-21 was significantly related with shorter overall survival (OS; 77.0 v 193.0 months; P =0.05) in HPV-negative OSCC, but not in HPV-positive OSCC (P =0.95). At HPV-stratified multivariate analysis, up-regulation of miR-21 was independent prognostic factor for both relapse-free survival (RFS; HR, 2.681; 95% CI, 1.090 to 6.591; P = 0.032) and OS (HR, 6.286; 95% CI, 2.047 to 19.302; P = 0.001). Conclusion: Up-regulation of miR-21 expression is closely associated with poor prognosis in HPV-negative OSCC, but not in HPV-positive OSCC, suggesting that miR-21 may have a different role according to the HPV infection status. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):B224. Citation Format: Yoon Ho Ko, Ho Jung An, Der Sheng Sun, Hye Sung Won, Jin Hyoung Kang, Chan-Kwon Jung. HPV-stratified analysis of prognostic role of miR-21 in oropharyngeal squamous cell carcinoma. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr B224.
Goonhilly: a new site for e-MERLIN and the EVN

Field: Physics and Astronomy (Physical Sciences)

The benefits for the e-MERLIN and EVN arrays of using antennae at the satellite communication station at Goonhilly in Cornwall are discussed. The location of this site - new to astronomy - will provide an almost equal distribution of long baselines in the east-west- and north-south directions, and opens up the possibility to get significantly improved observations of equatorial fields with e-MERLIN. These additional baselines will improve the sensitivity on a set of critical spatial scales and will increase the angular resolution of e-MERLIN by a factor of two. e-MERLIN observations, including many allocated under the e-MERLIN Legacy programme, will benefit from the enhanced angular resolution and imaging capability especially for sources close to or below the celestial equator (where ESO facilities such as ALMA will operate) of including the Goonhilly telescopes. Furthermore, the baselines formed between Goonhilly and the existing stations will close the gap between the baselines of e-MERLIN and those of the European VLBI Network (EVN) and therefore enhance the legacy value of e-MERLIN datasets.
The (Im)possibility of Global Citizenship Education in School Geography

Field: Social Sciences (Social Sciences)

Despite increasing concerns about the politics of curriculum for certain ideologies of global citizenship, there is scant literature focusing on critical understandings of school geography in relation to global citizenship (GC). This article examines the complicit relationship between dominant discourses of GC and South Korean curriculum policy and world geography textbooks. The language of global others is analyzed via postcolonial and post-structural thinking. Four themes of modernity, dichotomization, discrimination, and objectification emerge. This article articulates the ways in which these link closely to Western discourses of GC by legitimating certain types of geographical thinking while obscuring others.
Effect of different glucogenic to lipogenic nutrient ratios on rumen fermentation and bacterial community in vitro

Field: Agricultural and Biological Sciences (Life Sciences)

This study was to investigate the effect of different ratios of glucogenic to lipogenic nutrients on rumen fermentation and the corresponding ruminal bacterial communities. Four diets, including glucogenic diet (G), lipogenic diet (L), two mixed diets: GL1 (G: L = 2 : 1) and GL2 (G:L = 1 : 2), served as substrates and were incubated with rumen fluid in vitro. The results revealed that the gas production, dry matter digestibility and propionate proportion were significantly increased by the G diet than others. The G diet increased the bacterial genera of Succinivibrionaceae_UCG_002, Succinivibrio, Selenomonas_1 and Ruminobacter but decreased some cellulolytic bacteria including the Eubacterium and several genera in family Ruminococcaceae than others. When the glucogenic nutrient was above 1/3 of the dietary energy source among the four diets, the in vitro incubation had a higher feed digestibility and lower acetate to propionate ratio. Bacterial genera, including Selenomonas, Succinivibrio, Ruminobacter, certain genera in Ruminococcaceae, Christensenellaceae_R‐7_group and Eubacterium, were more sensitive to the glucogenic to lipogenic nutrients ratio. The present study provides a new perspective about the effect of dietary glucogenic to lipogenic ingredient ratios on rumen metabolism by comparing end‐products, gas production and bacterial composition via an in vitro technique.
Methodology and instrumentation for contaminant detection in wines, fruits and vegetables using bio et chemiluminescence (BCL)

Field: Agricultural and Biological Sciences (Life Sciences)

The aim of this work is to valid and improve rapid pesticide immunodetection in fruits, vegetables and beverages, using bio &#38; chemiLumininescence detection (BCL). Sensivity of BCL detection with a portable luminometer has been compared to colorimetry with a spectrophotometer. The application of BCL detection to the immunoassay of procymidone has given a better detection limit but a slightly worse repeatability than with colorimetry. The latter point might be explained by an heterogenous coating on the immunoassay tubes. When comparing a procymidone Elisa test coupled to BCL detection with gas chromatography, the analysis of samples contaminated in the field has yielded a 0.35 mg/kg Standard Error of Prediction (SEP) for grape and a 1.8mg/kg SEP for salad. Abstract of the paper 96F-050 : Pesticides detection in wines, fruits and vegetables by coupling immunoassays to Bio &#38; ChemiLuminescence (Issert V. ; Grenier P. ; Bellon Maurel V.). / L'objectif de cette recherche est de valider et d'améliorer la détection rapide par immunoessais dans les fruits, les légumes et les boissons, en utilisant la détection par bio &#38; chimiluminescence (BCL). La sensibilité de la détection BCL avec un luminomètre portable a été comparée à la colorimétrie par spectrophotomètre. L'application de la détection BCL à l'immunoessai de la procymidone a donné une meilleure limite de détection mais une répétabilité légèrement plus mauvaise qu'en colorimétrie. Ce dernier point pourrait être expliqué par un revêtement hétérogène des tubes d'immunoessais. En comparant un test procymidone Elisa associé à la détection BCL avec la chromatographie en phase gazeuse, l'analyse d'échantillons contaminés au champ est précisé avec une SEP de 0,35 mg/kg pour le raisin et 1,8 mg/kg pour la salade. Résumé de l'article 96F-050 : Pesticides detection in wines, fruits and vegetables by coupling immunoassays to Bio &#38; ChemiLuminescence ( Issert V. ; Grenier P. ; Bellon Maurel V.).
Priorities for mental health promotion during pregnancy and infancy in primary health care

Field: Health Professions (Health Sciences)

The perinatal period (shortly before and after birth) is a particularly significant stage, providing a sound base for healthy development. Primary health care should accompany the individual through the entire life cycle, and mental health problems constitute a public health threat that calls for the development of mental health promotion initiatives in primary health care. Responding, in 2004 our team initiated an action research project with the aim of reorganising primary health care during pregnancy and the first year of life. The aim is to enable health professionals to support families in the transition to parenthood, thereby promoting children's mental health. In order to plan this reorganisation, we developed a two-step decision-making process: 1. assessment of antenatal health care; 2. joint reflection concerning the priorities for change. The study goal was to assess the particular characteristics and needs of families during the perinatal period as well as the kind of care they were actually receiving. We designed a cross-sectional quantitative—qualitative study that collected data from users and health professionals using questionnaires and semi-structured interviews. The reflection step took place during a workshop that aimed to analyse the results and discuss priorities. The study confirmed the need to search for mental health problems during pregnancy, particularly to prevent a disturbed mother/child bonding process, and the importance of emphasising issues such as communication, information provision and the adequate availability of health professionals for antenatal care. The findings led to the following conclusions: 1. risk and needs assessment regarding mental health and options for family support should be included in the protocols of antenatal care; 2. primary health care professionals should be enabled to undertake diagnostic work and problem solving related to mental health; 3. collaboration between different levels of health care and between health sector and community resources should be increased. The highly participative decision-making process used led to a selection of priorities and strategies that was meaningful to users and health professionals and should contribute to the implementation and sustainability of changes for mental health promotion. (Global Health Promotion, 2009; 1 (1): pp. 29—38)
Success in Industrial Control System Cyber Security Training

Field: Computer Science (Physical Sciences)

posture of ICS in the national critical infrastructure. In support of the NSTB, INL hosts a dedicated SCADA testing facility which consists of multiple control systems supplied by leading national and international manufacturers. Within the test bed, INL researchers systematically examine control system components and work to identify vulnerabilities. In support of the CSSP, INL develops and conducts training courses which are designed to increase awareness and defensive capabilities for IT/Control System professionals. These trainings vary from web-based cyber security trainings for control systems engineers to more advanced hands-on training that culminates with a Red Team/ Blue Team exercise that is conducted within an actual control systems environment. INL also provides staffing and operational support to the DHS Industrial Control Systems Cyber Emergency Response Team (ICS-CERT) Security Operations Center which responds to and analyzes control systems cyber incidents across the 18 US critical infrastructure sectors.
Stock Watch

Field: Agricultural and Biological Sciences (Life Sciences)

The aim of this study was to investigate whether ultrasound (US) assistance during the osmotic pretreatment of sour cherries has any influence on quality and changes in the levels of bioactive compounds present in dried product during storage using an accelerated shelf-life test. Sour cherries of ‘Nefris’ variety were pitted in a frozen state and subjected to osmotic dehydration in a water bath fitted with ultrasound transducers (25 kHz, 0.4 W/cm2) and a shaking plate (30 rpm) in sucrose solution (60 °Bx, fruit to syrup ratio 1:4, 40 °C) and then convectively dried (60 °C, 9 h, 2.5 m/s). The osmotic dehydration lasted 120 min with (60US) and without US (0US) treatment. The application of US resulted in the enhancement of mass transfer after osmotic dehydration (higher dry matter content and lower water activity in dried 60US sample in comparison to 0US). Storage caused the deterioration of anthocyanin content and after 8 weeks of storage significant differences between samples became visible. Samples treated with US application had a lower antiradical capacity than those untreated. It can be anticipated that ultrasound application had a negative influence on anthocyanin content and may speed up the loss of antioxidant potential.
An attempt at oberving X-ray magnetic Bragg scattering.

Field: Physics and Astronomy (Physical Sciences)

Characteristics of X-ray magnetic Bragg scattering are discussed. Synchrotron X-ray radiation is proved to be a suitable source for examining X-ray magnetic scattering by means of polarization analysis or resonance scattering. Some eminance in X-ray magnetic Bragg scattering is pointed out.
Protein kinase activity required for an early step in interferon-alpha signaling.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Interferon-alpha (IFN alpha) induces an immediate transcriptional response of a restricted set of genes in target cells. Specific transcription is mediated by the cytoplasmic activation of a transcription factor complex termed ISGF3. ISGF3 is a multimeric protein complex composed of a regulatory component (ISGF3 alpha), which is activated following IFN alpha treatment, and a DNA-binding component (ISGF3 gamma), which recognizes the IFN alpha-stimulated response element (ISRE). Following activation, ISGF3 alpha translocates to the nucleus where ISGF3 assembles as a high affinity complex on the ISRE. The biochemical basis for receptor-mediated activation of ISGF3 is unknown. We report that two potent protein kinase inhibitors, staurosporine and K-252a, ablated the transcriptional response to IFN alpha treatment. These inhibitors prevented the activation of the ISGF3 alpha component without affecting the ISGF3 gamma component, resulting in no accumulation of mature ISGF3 in nuclei of treated cells. Although these agents are potent inhibitors of protein kinase C (PKC), PKC does not mediate ISGF3 alpha activation. Down-regulation of PKC by chronic exposure of cells to 12-O-tetradecanoylphorbol-13-acetate, which led to complete loss of PKC-immunoreactive material, failed to ablate the transcriptional response to IFN alpha or the activation of ISGF3 alpha. The PKC-specific inhibitor calphostin C did not perturb activation or nuclear accumulation of ISGF3. We conclude that a novel, staurosporine/K-252a-sensitive kinase is required for ISGF3 activity and may participate in receptor-mediated signal transduction.
Translational significance of a newly identified hepatocellular carcinoma tumor suppressor gene on chromosome 8p.

Field: Medicine (Health Sciences)

e15097 Background: After deletion of 17p that removes the tumor suppressor gene (TSG) TP53, deletion of 8p is the next most common chromosome abnormality in hepatocellular carcinoma (HCC). However, 8p TSG are insufficiently defined. Methods: Integrated genomic analysis of HCC and non-malignant liver obtained at therapeutic segmentectomy from the same patients. Results: A minimally deleted region on 8p was identified by SNP array. This incorporated GATA4. Therefore, GATA4 was Sanger sequenced in paired HCC/non-malignant liver: recurrent somatic non-synonymous missense mutations were identified in exon 4 (V267M n=5) or exon 6 (S357T n=6, R362N n=2, T366R n=2). Biallelic abnormalities were deletion and mutation (n=6) or mutation and uniparental disomy (n=4), with mutation or deletion of at least one GATA4 allele in 29/47 (62%) of HCC cases. The other GATA4 exons were mutation free. Although missense mutation is not intrinsically expected to decrease GATA4 expression, GATA4 mRNA was significantly decreased in cases with mutation as well as deletion (p<0.01) compared to non-malignant liver or wild-type GATA4 HCC. GATA4 drives liver differentiation, and the biological significance of GATA4 deficiency was demonstrated by significant enrichment (49%) for liver differentiation genes (p<1.2exp-124, Benjamini corrected) amongst genes with decreased expression in HCC compared to non-malignant liver. From an oncogenesis perspective, the most important of these hepatocyte genes (e.g., HNF4A, CEBPD) antagonize MYC to terminate proliferation: GATA4 introduction (expression vector) into HCC cells containing mutated or deleted GATA4 (HepG2 and PLC respectively) restored HNF4A and CEBPD expression, suppressed MYC protein, upregulated p27/CDKN1B that mediates cell cycle exit by maturation and significantly decreased HCC proliferation without apoptosis. In objectively quantified immunohistochemical analyses (ImageIQ), HCC cases with GATA4 mutation/deletion had significantly increased MYC protein (p<0.05). Conclusions: 8p deletion/GATA4 mutation in HCC suppresses cell cycle exit by maturation, thus complementing 17p deletion that suppresses cell cycle exit by apoptosis.
Live-Chat Support for People Bereaved by Suicide

Field: Psychology (Social Sciences)

Abstract. Background: People bereaved by suicide often face isolation, complicated grief, and increased suicide risk. Aims: We aimed to explore how live-chat can support survivors in their bereavement process. Method: A thematic analysis was carried out on 30 live-chat conversations through the software ATLAS.ti8. Transcripts were retrieved from a major Italian association providing online support. The users had different ages (18–60 years), degrees of kinship with the deceased (blood-related and not), and time distance from the loss (between 48 hr and 10 years). Results: Five themes were identified: meaning-making, reactions to the loss, resources, needs, and interactions with the operator. Survivors used the live-chat as a safe space in which to disclose nonsocially desirable details and to make sense of suicide through the reconstruction of events and the deceased's motivations. Given the limited social resources and the dissatisfaction with the available formal support, users resorted to justification, rationalization, or faith and found support and reassurance in the live chats. Limitations: Some conversations were fragmented and lacked detailed information on the users. Conclusion: Because of their anonymity and accessibility, live-chats represent a valid first-line form of support, from which survivors may obtain useful information and start a meaning-making process.