Retinoid metabolism and retinoic acid signaling in astrocytes and differentiating neural stem cells

Field: Neuroscience (Life Sciences)

Event Abstract Back to Event Retinoid metabolism and retinoic acid signaling in astrocytes and differentiating neural stem cells Barbara Orsolits1*, Gergo Vöfély1, Márta Jelitai1, Emília Madarász1 and Zsuzsanna Környei1 1 Hungarian Academy of Science, Institute of Experimental Medicine, Hungary Retinoic acid (RA) is widely used as a potent inducer of neuronal differentiation by various multipotent cell populations (embryonic carcinoma cells, embryonic and neural stem cells), in vitro. The in vitro studies suggest that RA may function as a regulator of neural stem cell fate in vivo. This implication is supported by earlier, as well as recent findings on retinoid signaling at sites of both embryonic and postnatal neurogenesis. In the present study, we explore the components of retinoid metabolism/signaling in differentiating neural stem cells as well as in astroglial cells isolated from hGFAP-GFP mice. Our recent data show, that the key enzymes of RA synthesis, the retinaldehyde dehydrogenases (RALDHs) are upregulated during neuronal differentiation. In line with this, RA production is elevated in the course of neuronal/glial differentiation. Based on earlier findings (Kornyei et al. 2007, FASEB J. 21(10):2496-509) we monitor vitamin A storing and retinoic acid producing capacity of both cultured and FACS-sorted astroglial cells. Conference: IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010. Presentation Type: Poster Presentation Topic: Development Citation: Orsolits B, Vöfély G, Jelitai M, Madarász E and Környei Z (2010). Retinoid metabolism and retinoic acid signaling in astrocytes and differentiating neural stem cells. Front. Neurosci. Conference Abstract: IBRO International Workshop 2010. doi: 10.3389/conf.fnins.2010.10.00013 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 16 Apr 2010; Published Online: 16 Apr 2010. * Correspondence: Barbara Orsolits, Hungarian Academy of Science, Institute of Experimental Medicine, Budapest, Hungary, orsolits@koki.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Barbara Orsolits Gergo Vöfély Márta Jelitai Emília Madarász Zsuzsanna Környei Google Barbara Orsolits Gergo Vöfély Márta Jelitai Emília Madarász Zsuzsanna Környei Google Scholar Barbara Orsolits Gergo Vöfély Márta Jelitai Emília Madarász Zsuzsanna Környei PubMed Barbara Orsolits Gergo Vöfély Márta Jelitai Emília Madarász Zsuzsanna Környei Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.