jimnoneill/paper-to-field-training huggingface dataset:
Validation of EHR medication fill data obtained through electronic linkage with pharmacies

Field: Health Professions (Health Sciences)

BACKGROUND: Recent linkages between electronic health records (EHRs) and pharmacy data hold opportunity for up-to-date assessment of medication adherence at the point of care. OBJECTIVE: To validate linked EHR-pharmacy data, which can be used for point-of-care interventions for concordance with insurance claims data for patients in a large health care delivery system. METHODS: We performed a retrospective cohort study of adult patients with an active antihypertensive medication order and seen as outpatients between August 25, 2019, and August 31, 2019. Pharmacy fill information was obtained from the EHR via linkages with Surescripts pharmacy and pharmacy benefit manager data, as well as from insurance claims available at our institution. We matched antihypertensive medication fills observed in the linked EHR-pharmacy database with available fills in the insurance claims database and calculated the percentage of medication fills that were available in each database. We estimated medication adherence using proportion of days covered in the linked EHR-pharmacy database and in the insurance claims database. RESULTS: Of 26,679 patients with hypertension, 23,348 (87.5%) had at least 1 antihypertensive medication fill recorded in the linked EHR-pharmacy database. Of 1,501 patients matched with the insurance database and with a documented medication fill, a fill was present for 1,484 (98.9%) and 1,259 (83.9%) patients in the linked EHR-pharmacy and insurance databases, respectively. Of 12,109 medication fills recorded in the insurance data, we found an overlap of 11,060 (91.3%) fills with the linked EHR-pharmacy database. The linked EHR-pharmacy database also contained 18,232 of 19,281 (94.6%) medication fills present in either database. Measured medication adherence was higher for patients when based on linked EHR-pharmacy data compared with insurance claims data (42% vs 30%, P < 0.001). CONCLUSIONS: Linked EHR-pharmacy data captured medication fills for the vast majority of patients and resulted in higher estimates of adherence than insurance claims. Our results suggest that pharmacy fill data available in the EHR have sufficient reliability to be used for point-of-care assessment of medication adherence. DISCLOSURES: This study was supported by grant R01HL155149 from the National Heart, Lung, and Blood Institute. Allen Thorpe provided funding for the NYU Langone Health Learning Health System Program, which helped fund this project. The authors have nothing to disclose.
“Choi! Touchshoot!” : exploring superstitious behavior of Singaporeans to develop commercially viable product.

Field: Arts and Humanities (Social Sciences)

Superstitious myths and taboos in Chinese culture are preached from generation to another, and often passed off as part of the human fabric. These beliefs infiltrated many Chinese Singaporean’s lifestyle, influencing their behavior and their perspective towards life. The thesis hence aims to explore and express such superstitious behavior of Chinese Singaporeans, with reference to a new and experimental research technique called On‐Site Situational Experiment (OSSE). The paper also discusses the importance of the role of Graphic Designers in a market‐driven society; For instance, the roles of Graphic designers to translate information elicited from the research, and produce a commercially viable product. Last but not least, the essay touches on the concept of ‘thematisation’ in Chinatown, and how the final product aims to bring about a unique and genuine light of Chinatown to Tourists, through the interesting superstitious behaviour of Chinese Singaporeans.
ANOMALIA EM GÔNADAS DE PARATI Mugil curema VALENCIENNES, 1836. (PISCES - MIGILIDAE)

Field: Agricultural and Biological Sciences (Life Sciences)

Aberrant gonadal development was observed in two females of Mugil curema Valenciennes, 1836 (Mugilidae) collected in Paranaguá Bay (Paraná - Brasil). Collections were taken from november of 1983 to february of 1985, comprising a total of 1020 individuals. This work describes and illustrates the observed malformation.
Primary Extranodal T-Cell Non-Hodgkin’s Lymphoma of the Gingiva in a HIV Patient

Field: Medicine (Health Sciences)

Since the appearance of AIDS, there has been a significant increase in the number of cases of oral Non-Hodgkin’s Lymphoma (NHL). These lesions may occur in the oral cavity, but rarely appear on the gingiva. Oral HIV-related lymphomas exhibit an aggressive course and can mimic other oral tumors and infections, this can make early recognition difficult but the diagnosis is important. It is now considered that oral NHL’s serves as the first indicator of HIV infection.
Free Electron Density Gradients Enhanced Biosensor for Ultrasensitive and Accurate Affinity Assessment of the Immunotherapy Drugs

Field: Chemical Engineering (Physical Sciences)

Abstract Accurate affinity assessments play an important role in drug discovery, screening, and efficacy evaluation. Label‐free affinity biosensors are recognized as a dependable and standard technology for addressing this challenge. This study constructs a free electron density gradient‐enhanced meta‐surface plasmon resonance (FED‐MSPR) biosensor through a finite‐difference time‐domain simulation model, the biosensor demonstrates superior detection performance in accurately determining affinity and kinetic rate constants. By controlling the dielectric properties of the metal on the surface of the nanocup arrays, the plasmon resonance effects are easily tuned without changing the nanostructure design. Compared with the single‐layer gold chip, the triple‐layer FED‐MSPR chip demonstrated a four‐fold improvement in resolution at the optimal resonance peak. Additionally, the sensitivity and figure of merit (FOM) of the multi‐layer chip increased by 3.5 and 7.99 times, respectively. Following modification with high‐ and low‐staggered carboxylation, the noise‐signal ratio and baseline stability of the real‐time kinetic curves based on these chips are significantly enhanced. The developed carboxylation FED‐MSPR platform is successfully used to perform affinity assays for Adalimumab and TNF‐α protein, resulting in favorable dynamic curves. These findings validate the proposed FED‐MSPR biosensor platform as cost‐effective, rapid, sensitive, and label‐free, facilitating real‐time quality control in drug development.
Energy Absorption Mechanism of a Particulate Dispersion Composite Material under Dynamic Loads of P and SV-Waves.

Field: Materials Science (Physical Sciences)

The energy absorption of a polymer particle to dynamic loads is discussed based on the linear theory of elastodynamics. Assuming incident waves, P and SV-waves, as the dynamic loads, the strain energy stored in the particle is obtained in graphical forms. It is shown that the ability of the energy absorption in the practical range is governed by the mode of circumferential deformation of the particle, when the frequency of the incident wave is lower. For the load of the incident P-wave, the zeroth mode of all round tension and compression of the particle deformation is the best deformation for absorbing the energy, however, for that of SV-wave, the second mode of elliptical deformation is the best.
Antidepressants for generalized anxiety disorder.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

As a group, antidepressants are an effective short-term treatment for GAD. Compared with placebo, about five to six patients must be treated to get one additional patient who responds to therapy. Side effects occur more frequently with antidepressants than with placebo, but they are not severe enough to require discontinuation of treatment.
HYBRID CHARGED SYSTEM SEARCH - PARTICLE SWARM OPTIMIZATION FOR DESIGN OF SINGLE-LAYER BARREL VAULT STRUCTURES

Field: Engineering (Physical Sciences)

The barrel vaults are composed of member elements arranged on a cylindrical surface. This kind of structure is utilized to cover the long spans. In this paper, the hybrid charge system search and particle swarm optimization algorithm is improved and utilized to optimal design of single-layer barrel vault frames. Some modifications on parameter values are performed to enhance the performance of the hybrid algorithm. Comparison of the results with other meta-heuristic algorithms illustrates the efficiency of the hybrid CSS and PSO algorithm. Also some discussion on the loading conditions and group selecting are presented.
Variable forgetting factor identification algorithm for fault diagnosis of wind turbines

Field: Engineering (Physical Sciences)

To diagnose the fault in the pitch actuator of wind turbines, a fault diagnosis method is proposed in this paper, which is based on the variable forgetting factor recursive least-squares(VFF-RLS) algorithm. According to the characteristic that the system parameters are changed by faults, the VFF-RLS system identification algorithm is adopted to estimate the changing parameters. The fault diagnosis problem is transformed into a parameter estimation issue. Then the time-varying natural frequency and damping ratio of pitch actuators are estimated based on the discrete model. The convergence rate and identification accuracy of the identification algorithm can be guaranteed by adjusting the forgetting factor automatically. The simulation results validate the effectiveness of the proposed method.
Principles, Paradigms, and Protections

Field: Arts and Humanities (Social Sciences)

Abstract The breadth of themes addressed in this issue of the Journal of Medicine and Philosophy is striking. These articles brim with some of the most foundational questions one can ask in bioethics and the philosophy of medicine: Under what circumstances might we risk some harm in pursuit of a greater good? In the setting of experimental therapies, how should we weigh the potential risk and benefit for an individual patient against the broader potential benefit realized for society as a whole? How might we consistently differentiate health from pathology? Under what circumstances might we say that a human being has died? Does acknowledging particular things (such as play) as good generate duties? Duties for whom and enforced by whom? These articles share a preoccupation with foundational questions that must be addressed in any sound bioethics curriculum, and they make clear that our answers to these questions are not simply theoretical but manifest in policy and in practice.
Impact of Telikom Training Centre on economic development of Papua New Guinea

Field: Social Sciences (Social Sciences)

The UNESCO UNEVOC Regional Conference was held at the Royal Melbourne Institute of Technology from 11-14 November 1996. The theme of the conference was 'Policy development and implementation of technical and vocational education for economic development in Asia and the Pacific'. Delegates from almost all UNEVOC countries attended the conference. This paper outlines the two phases of the project and shows how the objectives of the project have been largely achieved.
Business process reengineering of the supply chain process for cable material in an oil rig construction facility

Field: Decision Sciences (Social Sciences)

The management of an oil rig construction company wanted to improve information management in the cables supply chain process. The aim was to restructure the process during migration to a new information system to realize reductions in cycle time, operational costs and quality of information processed. Business Process Reengineering (BPR) methodology was used to gain understanding of the process flow, propose redesigns and quantify the benefits using simulation modeling. BPR guidelines for process redesign provided recommendations to improve efficiency by redesigning process flows. Changes to the process would result in elimination of unnecessary non-value-added steps and reduce cycle time. Simulation was used to determine optimal workflow design for the Engineering Coordinator to reduce delays. The proposed configuration of the workflow would result in an 89.23% reduction in average delay experienced to 10.17 hours with a utilization of 71.91% for the Engineering Coordinator.
Molecular Biology of Viruses of the HTLV Family

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Human T-cell leukemia/lymphoma virus (HTLV) consists of three major subgroups: HTLV-I, the etiological agent of adult T-cell leukemia, and HTLV-II, initially obtained also from a patient with a malignant disease, are both capable of transforming T-lymphocytes in vitro; HTLV-III, a cytopathic virus that apparently lacks transforming activity, is the etiological agent of the acquired immunodeficiency syndrome (AIDS). Members of the HTLV family contain genomes with a unique organization. In addition to the replicative genes (gag, pol and env), an additional gene and its product, a 42 kd protein, have been identified for HTLV-I and HTLV-II. This protein is likely to be important in initiation of transformation. Evidence suggests that it functions in transcriptional activation of viral and cellular genes in a manner analogous to some DNA tumor virus proteins. Analysis of the HTLV-III genome is less extensive, but suggests that this virus also has an extra coding sequence at the 3' end. Different isolates of HTLV-III exhibit considerable polymorphism, probably indicative of the highly replicative nature of this virus. In addition, a large amount of viral DNA persists in the unintegrated form both in continuously producing cell lines and in fresh biopsied tissues of AIDS patients. This finding may be relevant to the cytopathic effect of this virus.
Digital Financial Assets: Problems of Recognition, Valuation and Legal Regulation in Accounting

Field: Business, Management and Accounting (Social Sciences)

The article reveals the author’s vision of the recognition, valuation and legal regulation of accounting of digital assets at company level. The economic nature of cryptocurrency is discussed through interpreting the functions of money: a measure of value, a means of circulation, a means payment and accumulation, and the global money. It is concluded that cryptocurrency does not comply with the classical definition of “money”, because it does not feature its main functions. But it can be said that cryptocurrency constitutes the first opened, digital alternative currency able to take the form of traditional money. The procedure for cryptocurrency valuation in the business stocks and intangible assets is analyzed. In cases when a business entity is intended to buy cryptocurrency as a commodity, the transactions related to cryptocurrency flows should be recorded on the account 28 “Commodities”, whereas the transactions related to cryptocurrency production should be recorded on the account 26 “Finished products”. The proposed improvements in cryptocurrency accounting in the company stocks will be realizable when the transactions on cryptocurrency purchase or production (mining) are performed on permanent basis. The recognition of cryptocurrency in the intangible assets of a company will be feasible on the following conditions: cryptocurrency does not have a physical form; it can be identified; it is a non-monetary asset. The distinctive features of Bitcoin in relation to financial instruments are outlined, ways of cryptocurrency production using ІСО, mining, forging etc. are discussed. Regarding the legal regulation of cryptocurrency circulation in Ukraine, it is revealed that no normative and legal document exists to specify the legal status of the notions “virtual assets”, “digital financial assets” or “cryptocurrency”. By now, the draft law has been approved, intended to regulate purchase, sale and taxation of virtual assets. The official recognition of digital financial assets and blockchain technology is expected to promote the transition of Ukraine to the digital economy. This transition is going to give rise to the emergence of a new object of accounting, e. g. digital financial assets. The authors’ vision of the normative and legal regulation of cryptocurrency accounting at micro- and macrolevel allowed to propose a new national standard of accounting “Digital financial assets”, to develop a methodological framework for reporting the data on digital financial assets and their disclosure in the financial statements of companies.
Conservation assessment of five new records for the Orchidaceae of Colombia

Field: Agricultural and Biological Sciences (Life Sciences)

Following the IUCN criteria, we assess the risk of extinction for &#64257;ve orchid species recorded for the &#64257;rst time from Colombia: Acianthera viridis (Luer & Hirtz) Luer, Dichaea lankesteri Ames, Epidendrum lavendulum H&aacute;gsater, Masdevallia ariasii Luer, and Stenia stenioides (Garay) Dodson & R.Escobar. We propose a preliminary global Red List categories of Endangered, Least Concern, Endangered, Vulnerable, and Least Concern, respectively, for these species. The main threats of these orchids are habitat degradation, small and degraded AOO and EOO, and a small number of known populations. The Cara&ntilde;o river basin, where these species occur in Colombia, is an important site for orchid conservation. Consequently, strategies are needed to ensure its preservation.
Normal two-dimensional gel electrophoresis of alpha-2-macroglobulin in cystic fibrosis.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Some studies have suggested that a mutant form of alpha-2-macroglobulin (alpha-2-M) could be the primary defect in cystic fibrosis (CF). To test for the presence of charge change amino acid substitutions, alpha-2-M was examined by two-dimensional gel electrophoresis following complete denaturation of the proteins. The pattern of nine charge isomers observed was the same in homozygous, heterozygous, and normal individuals.
The Emotional Timeline of Unemployment: Anticipation, Reaction, and Adaptation

Field: Psychology (Social Sciences)

Abstract Unemployment continues to be one of the major challenges in industrialized societies. Aside from its economic and societal repercussions, questions concerning the subjective experience of unemployment have recently attracted increasing attention. Although existing studies have documented the detrimental effects of unemployment for cognitive (life satisfaction) and affective well-being, studies directly comparing these two dimensions of subjective well-being and their temporal dynamics in anticipation of and response to unemployment are absent from the literature. Using longitudinal data of the German Socio-Economic Panel (SOEP) and applying fixed effects regressions, we investigate changes in cognitive and affective well-being prior to and after job loss. Extending previous studies, we use discrete emotion measures instead of affect balance indicators to assess affective well-being. Our results support existing findings that unemployment leads to decreases in life satisfaction and that the unemployed do not adapt towards previous levels of life satisfaction. We also find that individuals more often experience sadness and anxiety, and less often happiness when transitioning into unemployment. Importantly, changes in affective well-being are less enduring compared to the changes in life satisfaction.
A methodology for analysing large-scale concurrent engineering systems

Field: Decision Sciences (Social Sciences)

SUMMARY A key problem in large-scale concurrent engineering systems is the control and management of the large amount of information required. Constraint networks that are used to represent this information can become so large that structural and operational problems are difficult to identify and rectify. This paper proposes a new approach, called Meta-nets, to modelling large-scale concurrent engineering problems. Meta-nets provide an abstraction of an underlying constraint network. The overall result is a compact and powerful representation of the information flow. The abstraction and analysis of Meta-nets gives several important benefits. First, by dealing with network structure based on information flow, Meta-nets can assist in network navigation. Second, Meta-nets give the dependence relationships between variables in the concurrent engineering system. Third, Meta-nets effectively represent parallelism (i.e. the carrying out of activities separately but with some measure of cohesion), which is an essential characteristic of concurrent engineering. This can form the basis for parallel processing. Fourth and finally, Meta-nets provide a methodology for breaking large concurrent engineering networks into more manageable sub-networks. These advantages become especially important for large-scale concurrent engineering problems. Notes ∗To whom correspondence should be addressed.
Electrochemical characterization of β,β′-butanoporphyrins containing sterically hinderedmeso-2,6-dihalogenophenyl substituents and first-row transition metal ions in nonaqueous media

Field: Chemistry (Physical Sciences)

Six [Formula: see text],[Formula: see text]-butano substituted metalloporphyrins containing sterically hindered meso-dihalogenophenyl substituents and first-row transition metal ions were synthesized and their electrochemical and spectroelectrochemical properties were characterized in nonaqueous media. The investigated compounds have the general formula butano(Y 2 Ph) 4 PorM, where Por is a dianion of the porphyrin, M = Mn[Formula: see text]Cl, Fe[Formula: see text]Cl, Co[Formula: see text], Ni[Formula: see text], Cu[Formula: see text] or Zn[Formula: see text]and Y 2 Ph is a sterically hindered 2,6-F 2 Ph or 2,6-Cl 2 Ph group on each of the four meso-positions of the macrocycle. The electrochemistry of each porphyrin was examined in CH 2 Cl 2 or pyridine containing 0.1 M tetra-[Formula: see text]-butylammonium perchlorate. The first one-electron reduction is metal-centered for the manganese(III), iron(III) and cobalt(II) porphyrins to generate the Mn(II), Fe(II) and Co(I) porphyrins, but it is porphyrin ring-centered for the other examined M(II) porphyrins to give porphyrin [Formula: see text]-anion radicals under the given solution conditions. The effect of the [Formula: see text],[Formula: see text]-butano and sterically hindered meso-Y 2 Ph substituents on redox potentials and electron transfer mechanisms are discussed and compared to what was previously reported for butano-substituted tetraarylporphyrins without hindered meso-substituents.
Entrepreneurship in State-Owned Enterprises. An International Comparative Analysis of iri , Temasek and öiag

Field: Business, Management and Accounting (Social Sciences)

In the last two decades, the global economy has witnessed the success of Chinese state-owned enterprises and a resurgence of soe s as integral parts of national industrial strategies. However, mainstream theory often fails to grasp the array of different soe typologies and the essence of state entrepreneurship. The purpose of this work is to identify a spectrum of soe s and entrepreneurial ways of running soe s through an international comparative analysis. Anevaluating framework based on the capacity of soe s to be visionary, to return rewards to the state, to achieve social goals, and to be independent is used to evaluate the performance of three soe s: iri , Temasek and öiag . All three companies are State Holding Companies since this type of soe provides the flexibility necessary to follow an entrepreneurial management style. This international comparative analysis highlights that, in order for soe s to be entrepreneurial, they must go beyond fixing market failures and that social goals are not necessarily in opposition to rewards, and to profitability in particular. The state should not just fix market failures, it must create new markets and new paths of development for national economies shc s can be effective tools in achieving these results.