jimnoneill/paper-to-field-training huggingface dataset:
Device‐estimated sleep metrics do not mediate the relation between race and blood pressure dipping in young black and white women

Field: Medicine (Health Sciences)

Abstract Short, disturbed, and irregular sleep may contribute to blunted nocturnal blood pressure (BP) dipping, a predictor of cardiovascular disease. Black women (BLW) demonstrate less BP dipping and poorer sleep health than White women (WHW). However, it remains unclear whether device‐estimated sleep health metrics mediate the relation between race and BP dipping in young women. We hypothesized that the relation between race and BP dipping would be partly mediated by sleep health metrics of sleep duration, sleep efficiency, and sleep regularity. Participants (20 BLW, 17 WHW) were 18–29 years old, normotensive, nonobese, and without evidence of sleep disorders. Systolic and diastolic BP dipping were derived from 24‐h ambulatory BP monitoring. Habitual sleep duration and sleep efficiency were estimated via 14 days of wrist actigraphy. Sleep duration regularity was calculated as the standard deviation (SD) of nightly sleep duration (SDSD). Sleep timing regularity metrics were calculated as the SD of sleep onset and sleep midpoint (SMSD). Mediation analysis tested the mediating effect of each sleep metric on the relation between race and BP dipping. BLW experienced less systolic ( P = .02) and diastolic ( P = .01) BP dipping. Sleep duration ( P = .14) was not different between groups. BLW had lower sleep efficiency ( P < .01) and higher SDSD ( P = .02), sleep onset SD ( P < .01) and SMSD ( P = .01). No sleep metrics mediated the relation between race and BP dipping (all indirect effects P > .38). In conclusion, mediation pathways of sleep health metrics do not explain racial differences in nocturnal BP dipping between young BLW and WHW.
Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Loss of function of any one of three UPF genes prevents the accelerated decay of nonsense mRNAs in Saccharomyces cerevisiae. We report the identification and DNA sequence of UPF3, which is present in one nonessential copy on chromosome VII. Upf3 contains three putative nuclear localization signal sequences, suggesting that it may be located in a different compartment than the cytoplasmic Upf1 protein. Epitope-tagged Upf3 (FLAG-Upf3) does not cofractionate with polyribosomes or 80S ribosomal particles. Double disruptions of UPF1 and UPF3 affect nonsense mRNA decay in a manner indistinguishable from single disruptions. These results suggest that the Upf proteins perform related functions in a common pathway.
Hepatic Lipase, Genetically Elevated High-Density Lipoprotein, and Risk of Ischemic Cardiovascular Disease

Field: Medicine (Health Sciences)

Abstract Context: Hepatic lipase influences metabolism of high-density lipoprotein (HDL), a risk factor for ischemic cardiovascular disease (ICD: ischemic heart disease and ischemic cerebrovascular disease). Objective: We tested the hypothesis that genetic variation in the hepatic lipase genetic variants V73M, N193S, S267F, L334F, T383M, and −480c&gt;t influence levels of lipids, lipoproteins, and apolipoproteins and risk of ICD. Design: For the cross-sectional study, we genotyped 9003 individuals from the Copenhagen City Heart Study; hereof were 8971 individuals included in the prospective study, 1747 of whom had incident ICD during 28 yr of follow-up. For the case-control studies, 2110 ischemic heart disease patients vs. 4899 controls and 769 ischemic cerebrovascular disease patients vs. 2836 controls, respectively, were genotyped. Follow-up was 100% complete. Results: HDL cholesterol was higher by 0.21 mmol/liter in S267F heterozygotes, by 0.06 mmol/liter in −480c&gt;t heterozygotes, and by 0.13 mmol/liter in −480c&gt;t homozygotes, as compared with noncarriers. These HDL increases theoretically predicted hazard ratios for ICD of 0.87 [95% confidence interval (CI) 0.84–0.90], 0.96 (95% CI 0.95–0.97), and 0.91 (95% CI 0.89–0.94), respectively; this calculation assumes that genetically elevated HDL levels confer decreased risk similar to common HDL elevations. In contrast, when all cases and controls were combined, the observed odds ratios for ICD for these three genetic variants vs. noncarriers were 1.19 (0.76–1.88), 1.04 (0.96–1.13), and 1.08 (0.89–1.30), respectively. Hazard/odds ratios for ICD in carriers vs. noncarriers of the four remaining hepatic lipase genetic variants did not differ consistently from 1.0. Conclusion: Hepatic lipase genetic variants with elevated levels of HDL cholesterol did not associate with risk of ICD.
[Advances in the application of claudins to tumor therapy].

Field: Medicine (Health Sciences)

Claudin proteins are the most crucial components of tight junctions, and play an essential role in maintaining cell polarity, regulating cell permeability and the intercellular ion. In recent years, many studies have shown that abnormality of claudins expression is implicated in the tumor progression. The expression correlates with tumor prognosis and can serve as a biomarker of prognosis and potential therapeutic targets. This review summarizes the current knowledge regarding claudin dysregulation in cancer and highlights the progress in claudin-based treatments.
Rectus Fascial Wrap: Early Results of a Modification of the Rectus Fascial Sling

Field: Medicine (Health Sciences)

We describe an operation that increases bladder neck resistance in patients with urinary incontinence. It is a modification of the rectus fascial sling that was designed as an adjunct to augmentation cystoplasty and is used in association with clean intermittent catheterization. The operation is performed by circumferentially wrapping a rectus fascial defatted free graft around the bladder neck and suturing it to appose the bladder neck. The procedure was done in 17 patients, including 10 with myelodysplasia, 3 with sacral lipoma, 3 with bladder exstrophy and 1 with nonneurogenic neurogenic bladder. Leak point pressure improved in patients in whom it was measured preoperatively and postoperatively. Complications developed in 5 patients, including difficulty with catheterization in 2, ventral hernia at the graft harvest site in 1, bladder calculus in 1 and detrusor hyperreflexia in 1. Early results with the bladder fascial wrap indicate that it has the ability to improve continence in patients with a dysfunctional bladder neck who have undergone augmentation.
Basic Principles of Antifungal Treatment

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

There are limited classes of antifungal agents available. Patients most at risk of fungal infections are the critically ill and immunocompromised individuals. An essential component of antifungal treatment is source control. Biomarkers are useful for supporting the diagnosis as well as to rule out a fungal infection. Azoles are inhibitors of CYP450 enzymes, and clinicians need to be aware of the risk of drug-drug interactions. Echinocandins have a low toxicity profile but are only available as an intravenous formulation and are generally less effective against moulds. Amphotericin B is a broad-spectrum antifungal agent and the treatment of choice against Mucorales. It can be nephrotoxic and infusion-related reactions occur.
Changes in the composition of rat liver chromatin fractions during diethylnitrosamine carcinogenesis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Research Article| November 01 1972 Changes in the composition of rat liver chromatin fractions during diethylnitrosamine carcinogenesis M Gronow M Gronow 1Department of Experimenital Pathology and Cancer Research, University of Leeds, Leeds LS2 3AR, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1972) 130 (1): 11P. https://doi.org/10.1042/bj1300011P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation M Gronow; Changes in the composition of rat liver chromatin fractions during diethylnitrosamine carcinogenesis. Biochem J 1 November 1972; 130 (1): 11P. doi: https://doi.org/10.1042/bj1300011P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1972 The Biochemical Society1972 Article PDF first page preview Close Modal You do not currently have access to this content.
MOESM2 of The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson’s disease mouse models

Field: Neuroscience (Life Sciences)

Additional file 2: Figure S1. Effect of PAP on the expression of iNOS, TNF-α, and IL-1β in LPS-stimulated rat primary microglia. Figure S2. Morphological changes of microglia in response to MPTP. Figure S3. High magnification images of GDNF-positive cells in the substantia nigra of MPTP-injected mice
Research and Design of Nand Flash Array From Host to Flash Translation Layer

Field: Computer Science (Physical Sciences)

Given the inherent limitations of flash memory, solid-state storage devices require a host controller and a flash translation layer (FTL) to address two major conflicts: the conflict between the limited erase endurance of flash memory and the expectation of longer usage time and the conflict between the insufficient per-die bandwidth of flash memory and the exponential growth in data throughput.This paper presents a hybrid architecture implemented with FPGA logic and embedded processors. FPGA hardware acceleration is utilized to meet the requirement of high bandwidth, while the Host-FTL flash translation layer architecture is used to address the varying workload demands. By separating the storage device from the flash translation layer, the host manages the flash channel using the command and message units provided by the system.The design of Host-FTL not only implements conventional software algorithms such as address mapping, wear leveling, and bad block management but also uses a “pipeline” strategy for regular writes and a “parallel page group” strategy for large file writes, after analyzing the bandwidth bottleneck of the system. The channel-level RAID array enhances data security, and the localized wear leveling increases the total amount of written data in the solid-state disk array.
Real world tablet-splitting prescription status of enteric-coated tablets of diclofenac sodium and aspirin

Field: Health Professions (Health Sciences)

This study aimed to investigate tablet-splitting prescription of enteric-coated tablets of diclofenac sodium and aspirin. We conducted a retrospective cross-sectional study using claims data collected by the Health Insurance Review and Assessment Service (HIRA) of Korea during 2016-2020. Of the 1,227,666 prescriptions of aspirin 100 mg enteric-coated tablet, 941 tablet-splitting prescriptions were identified, accounting for 0.1%. Of the 941 prescriptions, 41.7% (392) were prescribed for the elderly individuals aged 65 years. Of the 334 tablet-splitting cases with 15 or more consecutive days of prescription, 58.7% (196) were found in the elderly. Furthermore, 37.0% (37/100), 37.1% (13/35), and 40.4% (36/89) of cases with consecutive days of prescription of 31-60, 61-90 days, and more than 90 days, respectively, gastrointestinal disorders were found. Of the 53,868 prescriptions of diclofenac sodium 25 mg enteric-coated tablet, 2,248 tablet-splitting prescriptions were identified, accounting for 4.2%. Furthermore, of the 2,248 prescriptions, 53.0% (1,192) were prescribed for children under 5 years old, and 33.1% (744) were prescribed for children aged 5-9 years, respectively. We found that tablet-splitting prescription rate of diclofenac sodium 25 mg was high, especially in children. Gastrointestinal disorders were common in the tablet-splitting prescriptions of aspirin 100 mg, especially in the cases with 15 or more consecutive days of prescription.
Electrophoretic Mobility of α1at Anti-Trypsin in Infected and Non-Infected Sputum and Its Relationship to Leucocyte Elastase

Field: Medicine (Health Sciences)

Conference Abstract| September 01 1980 Electrophoretic Mobility of α1at Anti-Trypsin in Infected and Non-Infected Sputum and Its Relationship to Leucocyte Elastase R. A. Stockley; R. A. Stockley 1The General Hospital, Birmingham, U.K. Search for other works by this author on: This Site PubMed Google Scholar D. Burnett D. Burnett 2The General Hospital, Birmingham, U.K. Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1980) 59 (3): 12P. https://doi.org/10.1042/cs059012Pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation R. A. Stockley, D. Burnett; Electrophoretic Mobility of α1at Anti-Trypsin in Infected and Non-Infected Sputum and Its Relationship to Leucocyte Elastase. Clin Sci (Lond) 1 September 1980; 59 (3): 12P. doi: https://doi.org/10.1042/cs059012Pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1980 The Biochemical Society and the Medical Research Society1980 Article PDF first page preview Close Modal You do not currently have access to this content.
Effect of the structural modification of 2-benzylamino-4-(4-iodophenyl)amino-6-methylpyrimidine on the biological activity of its derivatives

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Modification of the aliphatic-aromatic moiety in the 2-benzylmino-4-(4-iodophenyl)amino-6-methylpyrimidine leads to a change in the site of biological action of the formed structural analogs.
Further delineation of 7p trisomy. Case report and review of literature.

Field: Medicine (Health Sciences)

The authors report on the 7th case of "de novo" 7p trisomy [46,XY,dup (7) (p15-pter)], followed during 6-and-a-half years. Through literature review, examination of pictures and dermatoglyphics, they try to contribute to the further definition of this multiple congenital anomaly syndrome. This entity, although several lengths of duplicated fragment or mosaicism, is characterized by high and large forehead flattened at the centre due to the abnormally large and persistent gaping anterior fontanel and sagittal (metopic sutures, consequent hypertelorism and broad nasal bridge, cutis laxa, often denounced by folded neck, joint and cardiovascular anomalies, psychomotor delay and a possible typical dermatoglyphic pattern. The phenotypic pattern seems to be similar in all the patients, although the association of anomalies appears to be correlated to the extension of the duplicated fragments.
The Role of Regional Airports in Connectivity and Regional Development

Field: Social Sciences (Social Sciences)

This article analyzes the contribution of regional airports in Colombia to the development of the domestic air transport network, and with it, to the connectivity of the regions and their social and economic development. The growth and evolution of Colombian regional airports are supported and driven by a set of public and investment policies, designed exclusively for the air sector and implemented, almost continuously, since the liberalization of the air transport industry in the country in the early 1990s and are still in development. Having said this, this work analyzes how the network of regional airports have been able to develop in two and a half decades through public policies, and later, how these airports have positively impacted connectivity and socioeconomic development in the territories. All this is done through the presentation and analysis of related indicators.
RESEARCH AND DEVELOPMENT ACTIVITIES FIXATION OF RADIOACTIVE RESIDUES, QUARTERLY PROGRESS REPORT, OCTOBER-DECEMBER 1961

Field: Environmental Science (Physical Sciences)

Resesrch and development activities in fixation of radioactive wastes are reported. Spray calcination, batch calcination, in-tank solidification, off- gas treatment, sorption snd extraction studies, low- and intermediate-level wastes, and high-level wastes are discussed. (M.C.G.)
Effect of Phosphate and Zinc application on dry matter yield and uptake of nutrients in Cowpea (Vigna unguiculata (L.) Walp.)

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract To find out the effect of P and Zn levels on dry matter yield, concentration and uptake of P and Zn in cowpea, a pot experiment was conducted in greenhouse. Phosphorus and zinc were added at the rate of 0, 20, 40, 80 and 160 ppm P and 0, 2.5, 5, and 10 ppm Zn, respectively. Response of P and Zn on dry matter yields of shoots and roots at 40 days and grain yield at maturity was observed upto 80 ppm P and 5 ppm Zn, respectively, and further increase in their levels decreased the yields. The addition of 10 ppm Zn decreased and 2.5 ppm Zn increased P concentration in different plant parts. The application of P decreased Zn concentration in different plant parts mainly at maturity stage. The available P and Zn at each harvesting stage were not affected by application of Zn and P, respectively, suggesting that P‐Zn interaction occurred somewhere in the plants not in the soil.
Theological themes in the work "Istina katolicsanska" of the fra Antun Bačić

Field: Arts and Humanities (Social Sciences)

Književnu djelatnost franjevaca na prostorima danasnje Hrvatske možemo pratiti sve od srednjeg vijeka. Pisana kultura franjevaca na narodnom, hrvatskom jeziku zapocela je u XVII. stoljecu pojavom fra Matije Divkovica. Tijekom toga stoljeca javljaju se i drugi franjevci koji pisu na narodnom jeziku, a cija su djela uglavnom duhovnog sadržaja i namijenjena su prije svega franjevcima Bosne Srebrene i katolickom puku koji oni pastoriziraju. Kroz XVIII. stoljece javlja se siri krug franjevackih pisaca, također pretežno s temama duhovnog sadržaja. U djelima franjevackih pisaca zapažaju se odjeci sirokog pokreta katolicke obnove koju je inicirao Tridentski koncil. Sabor je donio niz reformnih odluka koje su imale veliko znacenje za daljnju povijest Katolicke crkve. Zahvaljujuci teoloskoj i propovjednickoj literaturi zapadnih katolickih autora, književni rad franjevaca izrastao je iz neposrednog dodira s europskom pisanom kulturom. Književni rad franjevaca u XVIII. stoljecu bio je bitno određen njihovim pastoralnim potrebama u katolickom puku. Izlaganje temelja krscanskog nauka i njegova primjena u životu vjernika bila je primarna intencija te književnosti koja je odredila i njezin karakter. Na tom tragu treba promatrati život i djelovanje znamenitog franjevca fra Antuna Bacica, clana Franjevacke provincije Bosne Srebrene, rodom iz Vrbe kraj Broda na Savi. Zajedno sa fra Stjepanom Vilovom Bacic se smatra zacetnikom hrvatske kontroverzisticke teoloske literature s pravoslavnim krscanima na podrucju Slavonije i Podunavlja. Njegovo djelo Istina katolicsanska (1732.) prvo je takvo djelo među Hrvatima na tom tlu. Samo djelo je u svojoj biti propovjednicko, a sazdano je kao kontroverzijski katekizam. Cilj je ovoga rada izložiti glavne teoloske teme koje je Bacic iznio u ovome djelu, napose nacin na koji je raspravljao o pojedinim kontroverzama između katolika i pravoslavnih. Svakako sve to treba sagledati u okviru ondasnjih drustvenih i kulturnih prilika u kojima djeluju franjevci Bosne Srebrene, odnosno novoosnovane Kapistranske provincije.
The Mechanisms for the Oxidative Addition of Imidazolium Salts to a Group 9 Transition Metal Atom (Co0, Rh0, and Ir0) and a Group 10 Transition Metal Atom (Ni0, Pd0, and Pt0): A Theoretical Study

Field: Chemistry (Physical Sciences)

The potential energy surfaces of the oxidative addition reactions, L2M + imidazoliumcation → product and CpM′L + imidazolium cation → product (M = Ni, Pd, Pt; M′ = Co, Rh, Ir; Cp = η5-C5H5; L = 1,3-aryl-N-heterocyclic carbene (NHC), aryl = 2,4,6-trimethylphenyl), are studied at the M06-L/Def2-SVP level of theory. The theoretical findings show that the singlet-triplet splitting (∆Est = Etriplet − Esinglet) for the L2M and CpM′L species can be used to predict the reactivity for their oxidative additions. That is to say, current theoretical evidence suggests that both a 14-electron L2M complex and a 16-electron CpM′Lcomplex with a better electron-donating ligand L (such as NHC) result in a reduced ∆Est value and facilitate the oxidative addition to the saturated C─H bond. The theoretical results for this study are in good agreement with the obtainable experimental results and allow a number of predictions to be made.
Expression of Th17 Cells and Related Cytokines in Peripheral Blood of Patients with Psoriasis Vulgaris

Field: Immunology and Microbiology (Life Sciences)

Objective:To investigate the correlation between psoriasis vulgaris disease severity and disease course with levels of circulating Th17 cells,and related cytokines IL-17,IL-22 in the peripheral blood of patients with psoriasis vulgaris. Methods:Measurements of Th17 cells,IL-17 and IL-22 levels were obtained from blood samples of 60 patients with psoriasis vulgaris and 40 controls.Th17 cells and IL-17,IL-22 levels were determined by triple-color flow cytometry and ELISA respectively.Levels of Th17 cells,IL-17,and IL-22 were then correlated with PSAI scores and psoriasis disease course. Results:The percentage of Th17 cells in peripheral blood of psoriatics was higher than that of normal controls(4.71%±2.55% vs 0.55%±0.39%,P0.01),and the percentage of Th17 cells was positively correlated with PASI scores(r=0.47,P0.01).The percentage of Th17 cells did not correlate with disease course(r=0.09,P0.05).Serum level of IL-17 and IL-22 in psoriatics were higher than those of normal controls(IL-17: 24.02±12.31 vs 7.16±4.04,P0.01;IL-22: 18.32±8.14 vs 6.52±4.15,P0.01).There was a positive correlation between serum level of IL-17,IL-22 and PASI scores(r=0.46,P0.01;r=0.51,P0.01),while no correlation was found between serum level of IL-17,IL-22 and disease course(r=0.03,P0.05;r=0.19,P0.05). Conclusion:Th17 cells maybe play an important role in the pathogenesis of psoriasis vulgaris,and expression level of Th17 cells may be regarded as an immunological indicator for evaluation of disease severity and prognosis.Blocking expression of Th17 cells-related cytokines IL-17 and IL-22 may become a novel target for the treatment of psoriasis.
Capacitance wire-mesh sensor for fast measurement of phase fraction distributions

Field: Engineering (Physical Sciences)

We introduce a new wire-mesh sensor based on capacitance (permittivity) measurements. The sensor can be used to measure transient phase fraction distributions in a flow cross-section, such as in a pipe or other vessel, and is able to discriminate fluids having different relative permittivity (dielectric constant) values in a multiphase flow. We designed and manufactured a prototype sensor which comprises two planes of 16 wires each. The wires are evenly distributed across the measuring cross-section, and measurement is performed at the wire crossings. Time resolution of the prototype sensor is 625 frames per second. Sensor and measuring electronics were evaluated showing good stability and accuracy in the capacitance measurement. The wire-mesh sensor was tested in a silicone oil/water two-phase bubbly flow.