jimnoneill/paper-to-field-training huggingface dataset:
Sexually Induced Orgasm to Improve Postpartum Pelvic Floor Muscle Strength and Sexual Function in Primiparous Women After Vaginal Delivery: A Prospective Randomized Two-Arm Study

Field: Medicine (Health Sciences)

Abstract Background Postpartum pelvic floor dysfunction is known to affect the quality of life of women and the methods to treat it are more complex with majority requiring training under supervision. Aim To compare the efficacy of sexually induced orgasm along with Kegels exercises versus Kegels exercises alone as a treatment method to enhance postpartum pelvic floor muscle strength and sexual function in primiparous women undergoing uncomplicated vaginal deliveries. Methods The prospective randomized two-arm study was conducted on sexually active primiparous women who had undergone uncomplicated vaginal deliveries. Those with risk factors for female sexual dysfunction and pelvic floor muscle dysfunction were excluded. Participants in Group 1 were advised daily Kegel's exercises, whereas, those in Group 2 were advised to initiate self-initiated/partnered sexual activity-induced orgasms along with daily Kegel's exercises. Their pelvic floor muscle strength on voluntary contraction, ability to relax pelvic floor voluntarily, and sexual function (using FSFI-6) were assessed monthly for 6 months and the analysis was done using G* Power software (© 2021 Heinrich-Heine-Universität Düsseldorf, Germany). Main Outcome Measure Postpartum pelvic floor strength and sexual function in 2 groups of women under study. Results The study period was from January 2020 to December 2020. The Group 1 had 26 participants (mean age 29.69 ± 2.2 years) and Group 2 had 29 participants (mean age 30.07 ± 2.57 years). The sexual function as well as ability to relax pelvic floor were significantly better in Group 2 compared to Group 1 at each monthly intervals whereas strength of pelvic floor muscles during voluntary contraction was significantly higher in Group 2 compared to Group 1 at the end of 6 months and it was statistically significant at a P value of .05. Clinical Implications Novel method of using naturally occurring sexually induced orgasms for postpartum pelvic floor rehabilitation can revolutionize postpartum pelvic floor training in women, as it can be practiced at home with ease, along with easily performable Kegel's exercises. Strengths and Limitations Use of prospective randomization and minimization of confounding factors is the strength of the study. The small sample size is the limitation of the study. Conclusions Postpartum pelvic floor muscle strength and sexual function in primiparous women who have undergone uncomplicated vaginal deliveries can be significantly improved with the addition of sexually induced orgasm as a therapeutic tool along with physical exercises such as Kegels exercises in these women.
Specificity of the DST and the TRH test for major depression in alcoholics

Field: Medicine (Health Sciences)

The authors examined dexamethasone suppression test (DST) and thyrotropin-releasing hormone (TRH) test results in 32 chronic alcoholics without depression or hepatic disease to see if alcoholism alone might lead to positive test results. After 3 weeks of sobriety there were no DST abnormalities, but blunted TRH test results were observed in eight of the 32 alcoholics. More of the 15 patients also tested during alcohol withdrawal than of the 20 normal subjects or the 32 alcoholics without alcohol withdrawal had DST and TRH test abnormalities. When performed after 3 weeks of sobriety, the DST but not the TRH test has potential as a specific laboratory adjunct in the diagnosis of depression in alcoholics.
Multidisciplinary modeling and simulation of a fuel cell/gas turbine hybrid power system

Field: Energy (Physical Sciences)

The fuel cell/gas-turbine hybrid power systems can utilize exhaust fuel and waste heat from fuel cells to increase the system efficiency. This paper considers an internally reforming solid oxide fuel cell/gas turbine (SOFC/GT) hybrid system, where the anode exhaust, which contains the remainder of the fuel, is mixed with the cathode exhaust as well as an additional supply of fuel and compressed air and then burned in a catalytic oxidizer. The hot oxidizer exhaust is expanded through the turbine section, driving an electric generator. After leaving the gas turbine, the oxidizer exhaust passes through a heat recovery unit in which it preheats the compressed air that is to be supplied to the fuel cell and the oxidizer. This paper concentrates on multidisciplinary modeling and simulation of the fuel cell/gas turbine hybrid power system. Transient response of the hybrid energy system is studied through time-domain simulation.
Cardiovascular effects of calcitonin gene-related peptide in conscious dogs

Field: Medicine (Health Sciences)

To elucidate the cardiovascular effects of alpha-human calcitonin gene-related peptide (CGRP), we infused CGRP intravenously at increasing rates of 3, 10, and 30 pmol.kg-1.min-1 during successive 15-min intervals into intact dogs, cardiac-denervated (CD) dogs, and cardiac-denervated dogs pretreated with beta-blockers. In intact dogs, the initial infusion rate of CGRP at 3 pmol.kg-1.min-1 did not produce significant hemodynamic changes, but the two higher infusion rates produced dose-dependent decreases in total peripheral resistance, mean arterial pressure, and left and right atrial pressures and produced dose-dependent increases in heart rate (HR) and cardiac output (CO). In addition, stroke volume decreased and pulmonary vascular resistance increased at the highest infusion rate. In CD dogs, CGRP produced qualitatively similar responses, although the increase in HR was markedly attenuated. The increase in CO was also attenuated, but the difference did not reach statistical significance. In CD dogs pretreated with beta-blockers, CGRP did not increase HR and the increase in CO was further attenuated. In a separate experiment, the lowest dose of CGRP (3 pmol.kg-1.min-1) was infused intravenously for 60 min in intact dogs; significant cardiovascular responses, qualitatively similar to those produced by higher rates of infusion, occurred. We conclude that CGRP is an extremely potent vasodilator and that the increase in HR is mediated primarily by autonomic reflexes.
Board Gender Diversity and Environmental, Social, and Governance (ESG) Disclosure in Developed Countries

Field: Business, Management and Accounting (Social Sciences)

This paper examines the relationship between board gender diversity and Environmental, Social, and Governance (ESG) disclosure in developed economies. Using a sample of forty-five firms across developed countries between 2012 and 2023, the analysis employs Bloomberg’s ESG disclosure score as a proxy. In terms of methodology, both pooled ordinary least squares (OLS) and fixed effects regression models are employed. However, to mitigate potential endogeneity concerns, the study employs an instrumental variable approach and dynamic panel regression techniques to provide robust causal inference. The findings offer two significant insights. In accordance with critical mass theory, firms with a minimum of three female directors demonstrate a significant positive relationship between board gender diversity and ESG disclosure. This indicates that achieving a critical level of female representation is essential for fostering meaningful improvements in ESG disclosure scores. Second, firms with merely one or two female directors, often considered token representation, exhibit a negative significant impact on ESG disclosure. Additionally, within the UK context, board gender diversity is positively associated with ESG disclosure, suggesting that institutional frameworks and regulatory environment shape this relationship.
Bilateral Alternate Orbital and Ocular Manifestations in a VEXAS Syndrome Patient

Field: Medicine (Health Sciences)

This case emphasises the importance of considering VEXAS syndrome in the diagnosis of patients with recurrent orbital and ocular inflammation. It also reiterates the effectiveness of corticosteroids and tocilizumab association in managing this complex condition, contributing to the growing understanding of VEXAS syndrome and its ophthalmological features.
Superconductivity in ultrathin Pb films deposited on silicon

Field: Physics and Astronomy (Physical Sciences)

Saperconducting Pb films 11 to 200 \AA{} thick have been deposited in ultrahigh vacuum on the clean (111) surface of crystalline silicon. Low-energy-electron diffraction indicated that the Pb preferentially grows with the Pb (111) plane parallel to the substrate surface. Measurements of normal-state film resistivity and of the superconducting transition temperature ${T}_{c}$ were taken in situ. The dependence of ${T}_{c}$ on film thickness was essentially identical to that previously measured for Pb films grown epitaxially on crystalline PbTe. This result is discussed in view of the dissimilarities between the two substrate materials.
Administration of IV medications via soluset.

Field: Nursing (Health Sciences)

Complete intravenous (IV) drug administration to a pediatric patient is an important nursing intervention. Verification of the amount of flush solution that is necessary to deliver > 95% of an IV medication to the patient was the goal of a laboratory demonstration and a clinical study. In the laboratory, it was determined that three times the volume of the dead space of the IV tubing was the required volume needed to flush dye from IV administration sets. This principle was then applied to pediatric patients receiving tobramycin medication therapy. Nurses administered tobramycin through 27 IV solusets of patients using three measured volumes of IV flush solution. Samples were collected from the IV tubing and analyzed to measure the concentration of tobramycin in the tubing. All three resulted in administration of > 95% of the medication. A nursing procedure was written to standardize the administration of IV medications to pediatric patients using two times the volume of the dead space of the IV tubing as the flush volume.
Genotype-Phenotype correlation in Dravet Syndrome with SCN1A mutation increase efficiency of molecular diagnosis

Field: Medicine (Health Sciences)

OBJECTIVES: The purpose of this study was to advance the knowledge on the clinical use of SCN1A testing for severe epilepsies within the spectrum of generalized epilepsy with febrile seizures plus by performing genetic screening in patients with Dravet and Doose syndromes and establishing genotype-phenotype correlations. METHODS: Mutation screening in SCN1A was performed in 15 patients with Dravet syndrome and 13 with Doose syndrome. Eight prediction algorithms were used to analyze the impact of the mutations in putative protein function. Furthermore, all SCN1A mutations previously published were compiled and analyzed. In addition, Multiplex Ligation-Dependent Probe Amplification (MLPA) technique was used to detect possible copy number variations within SCN1A. RESULTS: Twelve mutations were identified in patients with Dravet syndrome, while patients with Doose syndrome showed no mutations. Our results show that the most common type of mutation found is missense, and that they are mostly located in the pore region and the N- and C-terminal of the protein. No copy number variants in SCN1A were identified in our cohort. CONCLUSIONS: SCN1A testing is clinically useful for patients with Dravet syndrome, but not for those with Doose syndrome, since both syndromes do not seem to share the same genetic basis. Our results indicate that indeed missense mutations can cause severe phenotypes depending on its location and the type of amino-acid substitution. Moreover, our strategy for predicting deleterious effect of mutations using multiple computation algorithms was efficient for most of the mutations identified.
Development of TaqMan quantitative real-time PCR assay for detection of porcine RIG-1,TLR-9,IRF-3 and IRF-7

Field: Veterinary (Health Sciences)

In this study,a real-time PCR assays based on TaqMan probes for detection of retinoic acid-inducible gene 1(RIG-1),toll-like receptor 9(TLR-9),interferon regulate factor 3(IRF-3),interferon regulate factor 7(IRF-7) and β-actin were established with specific primers and probes of each gene.The results indicated that the assays were specific and highly sensitive with a detection limit of 1.0×10 copies/mL,and the coefficient of variation were less than 3% for both inter-and intra-assay.The established assays were used to detect mRNA transcription levels of RIG-1,TLR-9,IRF-3 and IRF-7 controled with β-actin in ST cells infected with porcine parvovirus.The results showed the transcription levels of TLR-9mRNA was down-regulated,and others showed up-regulared.The assays with highly specific,sensitive and reproducibility could be used to detect and quantify the signal transduction factors in porcine cells.
Non-invasive management of interstitial cystitis

Field: Medicine (Health Sciences)

Hirsutism, menstrual disorders, acne, and chronic anovulation are symptoms typically associated with disorders affecting androgen secretion and metabolism in adolescent girls (Table 1). In prepubertal children, androgen excess is associated with premature pubarche, which is defined as the development of pubic hair, axillary hair, acne, and/or adult-type apocrine odor earlier than eight years in girls and nine years in boys. Hyperandrogenemia is generally due to excessive androgen secretion by the adrenal cortex, ovaries, or testes. Additional manifestations of hyperandrogenemia include menstrual disorders, clitoral enlargement, masculine body habitus, male-pattern baldness, voice changes, and breast atrophy. The magnitude of the clinical features of androgen excess does not always correlate with circulating androgen concentrations.
Noninvasive assessment of gut function using transcriptional recording sentinel cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Transcriptional recording by CRISPR spacer acquisition from RNA endows engineered Escherichia coli with synthetic memory, which through Record-seq reveals transcriptome-scale records. Microbial sentinels that traverse the gastrointestinal tract capture a wide range of genes and pathways that describe interactions with the host, including quantitative shifts in the molecular environment that result from alterations in the host diet, induced inflammation, and microbiome complexity. We demonstrate multiplexed recording using barcoded CRISPR arrays, enabling the reconstruction of transcriptional histories of isogenic bacterial strains in vivo. Record-seq therefore provides a scalable, noninvasive platform for interrogating intestinal and microbial physiology throughout the length of the intestine without manipulations to host physiology and can determine how single microbial genetic differences alter the way in which the microbe adapts to the host intestinal environment.
Allicin suppressed Escherichia coli-induced urinary tract infections by a novel MALT1/NF-κB pathway

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Our experiments revealed that the therapeutic effects of allicin against E . coli induced urinary inflammation were characterized by the restoration of the highly expressed MALT1, the activated AKT/NF-κB pathway, and excessive release of cytokines.
[The approaches to realization of the therapeutic action of gas-air carbonate baths and lysozyme inhalation during their combined application for the treatment of patients presenting with chronic obstructive pulmonary disease].

Field: Medicine (Health Sciences)

The results of this study indicate that the application of gas-air carbonate baths resulted in the reduction of alveolar hypoxia, moderate increase in the patency of central bronchi, marked improvement of pulmonary and systemic cardiohemodynamics, and functional state of cellular immunity. Courses of lysozyme inhalation promoted degradation of the inflammatory process, reduction of disturbances in the mucociliary function, and improved functioning of the humoral component of the immune system. The combined application of rehabilitative technologies had the well apparent anti-inflammatory and immunocorrective effect, decreased general bronchial obstruction and hypoxia, improved pulmonary and systemic hemodynamics and contractile activity of the myocardium, and suppressed lung hypertension. These findings suggest complementary and additive action of the methods employed in the present study.
Improving the High-Frequency Response of PEI-Based Earphone with Sodium Copper Chlorophyllin

Field: Materials Science (Physical Sciences)

The polyetherimide diaphragm, sodium copper chlorophyllin (SCC), and copper ion coating composite used on earphones were observed to improve the high-frequency (10k–14k Hz) performance. This reinforcement phenomenon was expected to make the sound experience brighter and more diverse. By SEM observation, the mixed coating of SCC/Cu2+ on the polyethylenimine (PEI) diaphragm exhibited a planar blocky structure and was tightly bonded to the surface of the PEI polymer without the aid of colloids. The endothermic process of SCC and metal ion complexation was analyzed by isothermal titration calorimetry. The association ratios of SCC/Cu2+ and SCC/Ni2+ were 4/1 and 6/1, respectively, and the SCC/Cu2+ association yielded a stronger binding constant and more free energy. It was expected that the SCC/Cu2+(4/1) mixed liquid would be immobilized on the PEI polymer by multivalent interaction, including hydrogen-bonding networks between carboxyl groups of SCC and amine groups of PEI, and cross-linking of bridging copper ions. We used dimethylethylenediamine (DME) monomer instead of PEI polymer to analyze this multivalent interaction and observed a two-stage exothermic association of SCC/Cu2+(4/1) and DME with a total Gibbs free energy of 15.15 kcal/mol. We observed that the binding energy could be used to explain that the SCC/Cu2+ mixed formulation could be fixed on the surface of the PEI polymer and could enhance the strength of the PEI film. Compared with graphene films, which can continuously improve the performance of high and ultrasonic frequencies, this study was devoted to and was initiated for the purpose of applying porphyrin compounds to improve music performance.
Jung and Aion: Time, Vision, and a Wayfaring Man

Field: Arts and Humanities (Social Sciences)

C. G. Jung stated in 1957 that the visionary experiences recorded in The Red Book: Liber Novus were the foundation of his life work: “My entire life consisted in elaborating what had burst forth from the unconscious and flooded me like an enigmatic stream … the numinous beginning, which contained everything, was then.” Liber Novus is now historically placed in a hermeneutic relationship with Jung's subsequent writings.
Remarks On The Standard Hylleraas-Undheim And MacDonald Computation Of Excited States

Field: Physics and Astronomy (Physical Sciences)

For the computation of excited states, the standard solutions of the Schroedinger equation, using higher roots of a secular equation in a finite N-dimensional function space, by the Hylleraas-Undheim and MacDonald theorem, have several restrictions, which render them of lower quality, relative to the lowest root, if the latter is good enough. These deficiencies are reported, that prevent from comparisons with accurate experiments.
Occurrence Download

Field: Agricultural and Biological Sciences (Life Sciences)

A dataset containing 91 species occurrences available in GBIF matching the query: { "and" : [ "TaxonKey is Arachis glabrata", "Country is United States of America", "HasCoordinate is true" ] } The dataset includes 91 records from 8 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0058907-250920141307145/datasets/export for details. Data from some individual datasets included in this download may be licensed under less restrictive terms.
CORRELATION BETWEEN DIGNITY, EMPATHY AND EMPLOYEE PRODUCTIVITY AMONG WORKERS IN PRIVATE HOSPITALS IN RIVERS STATE.

Field: Social Sciences (Social Sciences)

The dignity of an employee alongside empathy as measures of work humanization are significant correlates of employee productivity which can be exploited for organizational growth. It is recommended that organizations through institutionalized policies can successfully manage their workplace for optimal productivity via improved employee dignity and empathy as a means of increasing job satisfaction and reduce brain drain.
Warm and Dry Spells (WDS) in Austral Winter over Central South America

Field: Earth and Planetary Sciences (Physical Sciences)

Abstract. The horizontal and vertical structure of unusually warm and dry spells (WDS) over the central parts of South America during the winter and post-winter months (JJAS) are studied. During WDS the mean temperature and humidity anomalies over central Brazil are about +4.1°C and −13.2%, respectively. The mean duration of WDS is 11 days and their mean frequency is less than one per year during the months of JJAS. Apparently, WDS have no preference for the phase of ENSO. Widespread and persistent subsidence in the middle troposphere is observed in tropical Brazil during WDS, which renders the lower tropospheric air warm and dry. The negative anomalies of the specific humidity are observed to be associated with the subsidence regions. A strong, slow moving ridge in the eastern South Pacific and a low-pressure center in northern Argentina are important surface characteristics during the WDS. A more detailed investigation of two specific WDS events, a strong event (August–September 1999) and a moderate one (June 2002), shows a blocking-like situation in the 500-hPa geopotential and surface pressure fields in the Pacific. The South Atlantic subtropical high somewhat approaches the continent. Strong northerlies over the central and eastern parts of Brazil are also observed in the lower troposphere. During WDS the regional circulation acquires summertime characteristics, except for the absence of precipitation, and the circulation in the meridional plane is in the opposite sense from the Hadley circulation. A frontal system, supported by a 500-hPa trough, advances into central Brazil, causing the dissipation of the anomalous situation.
The TAIPPP pilot experiment

Field: Physics and Astronomy (Physical Sciences)

Time transfer techniques using GNSS carrier phase and code signals are increasingly used in time metrology. In order to study the introduction of these techniques for TAI computation, the BIPM initiated a pilot experiment, named TAIPPP, where time laboratories contribute GPS phase and code data and where the BIPM uses the precise point positioning technique to generate monthly solutions, in slightly deferred time after the regular TAI computation. This paper reports on results obtained from this experiment after one year.
DNA Biopolymer Photonics

Field: Chemistry (Physical Sciences)

Deoxyribonucleic acid (DNA), besides its wide usage in biology and nanotechnology, has recently emerged as a promising biomaterial for photonics and optoelectronic applications. Here we provide a short overview of general properties of DNA biopolymer derived from natural sources and present our recent efforts toward the development and characterization of DNA biopolymer devices.