jimnoneill/paper-to-field-training huggingface dataset:
Combination immunotherapy with IDO vaccine and PD-1 inhibitors in advanced NSCLC.

Field: Medicine (Health Sciences)

TPS2610 Background: Multible checkpoints regulate host immune response, and development has focused on three of these: IDO, CTLA-4 and PD-1. Presently, several checkpoint inhibitors have been approved for advanced NSCLC including nivolumab, pembrolizumab, and atezolizumab all targeting PD-1 and PD-L1. Depending on level of PD-L1 tumor expression, response rates vary, and a substantial proportion of patients do not respond to treatment with immune checkpoint inhibitors. The combination of checkpoint inhibitors have been shown in malignant melanoma and other tumor types to clearly increase the effect. IO102 is a synthetic peptide under development as an immune-modulatory agent targeting cells expressing indoleamine 2,3-dioxygenase (IDO). IDO potently inhibits T-cell immunity in patients with cancer. Treatment with IO102 in NSCLC patients after first line palliative chemotherapy lead to long PFS in a number of patients in a small single arm study. Methods: IO102-001 is a randomized, double-blinded Phase 2 trial to evaluate the safety and efficacy of IO102 in combination with anti-PD-1 mAb in locally advanced and/or metastatic NSCLC stage III-IV patients eligible for anti-PD-1 mAb 2nd line treatment after first line of chemotherapy. Patients are randomized (2:1) to either a PD-1 inhibitor + IO201 vaccine or a PD-1 inhibitor (SOC). The PD-1 inhibitor will be administered according to label while IO102 will be given as s.c. injection every 2 weeks for the first 12 weeks, and subsequently every 4 weeks for 12 months or until progression, death or withdrawal from trial, whichever comes first. Treatment is continued to progression, unacceptable toxicity or withdrawal of consent. Main inclusion criteria is patients diagnosed with locally advanced and/or metastatic NSCLC Stage III-IV, measurable disease according to RECIST (1.1), patients eligible for anti PD-1 mAb treatment after 1st line of chemotherapy , ECOG performance status 0 or 1 and available tumor tissue for further analysis. A total of 90 patients will be included in the trial, and the trial will be active in countries in Europe and the US from Q2 2017.
ChemInform Abstract: Synthesis and Characterization of a Carbene‐Generating Biotinylated Lactosylceramide Analogue as a Novel Chromogenic Photoprobe for GM3 Synthase.

Field: Chemistry (Physical Sciences)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
MicroRNA profiling reveals opposing expression patterns for miR-511 in alternatively and classically activated macrophages

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Background: Macrophages are heterogeneous cells, which possess pleotropic effector and immunoregulatory functions. The phenotypic diversity of macrophages is best exemplified by the ability of IL-4 or IL-13, two key cytokines in asthma to promote macrophages into a suppressive/anti-inflammatory phenotype (e.g. alternatively activated or M2) whereas exposure to IFN-γ followed by microbial trigger renders macrophages pro-inflammatory (e.g. classically activated or M1). Intriguingly, only limited data exists regarding the expression of miRNA in M2 macrophages. Objective: To define the miRNA profile of M2 and M1 macrophages. Methods: Bone marrow-derived macrophages were activated to classically and alternatively activated states using IL-4, IL-13 or IFN-γ followed by Escherichia coli stimulation. Thereafter, an unbiased miRNA “mining” approach was utilized and the expression of several miRNAs was validated following in-vitro and in-vivo macrophage activation (qPCR). miR-511 over-expression was performed followed by global transcriptional and bioinformatic analyses. Results: We report unique miRNA expression profiles in M2 and M1 macrophages involving multiple miRNAs. Among these miRNAs, we established that miR-511 is increased in macrophages following IL-4- and IL-13-stimulation and decreased in M1 macrophages both in-vitro and in-vivo. Increased miR-511 expression was sufficient to induce marked transcriptional changes in macrophages. Interestingly, bioinformatics analyses revealed that miR-511 altered the expression of gene products that are associated with hallmark alternatively activated macrophage functions, such as cellular proliferation, wound healing responses and inflammation. Conclusions: Our data establish miR-511 as a bona fide M2-associated miRNA. These data may have significant implications in asthma where the expression of IL-4 and IL-13 are highly increased.
Nanoparticulate Drug Carrier Technology

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

This chapter provides an overview of the techniques to produce nanoparticles and nanocapsules, and to classify them based on the polymer properties and their ability to encapsulate different types of drugs. A major effect in the pharmaceutical field has been caused by the use of colloidal dispersions of biodegradable polymers as nanoparticulate drug carriers. While taking into account the high potential of polymeric colloidal suspensions as drug carriers, the purpose of the present chapter will be to review those made of polymers that are considered biodegradable and biocompatible. Water-soluble drugs may be associated with poly(alkylcyanoacrylates) nanospheres either by dissolving the drug in the aqueous polymerization medium or by incubating blank nanospheres in an aqueous solution of the drug. Solvent extraction-evaporation techniques have been applied to mainly the encapsulation of lipophilic drugs, which can be dissolved in the polymer solution. The technologies of producing colloidal dispersions from nonbiodegradable polymers have a relative short history in the pharmaceutical field.
Structure and evolution analysis of the Blue Lees typhoon with radar and satellite data

Field: Earth and Planetary Sciences (Physical Sciences)

The structure and evolution of blue Lees typhoon are studied with the Doppler radar and satellite data. Remote sensing data reveal more information about the eye of typhoon, the cloud phase state, the high cloud and low cloud. Especially, the ozone data could give the useful message to distinguish the high and low cloud. We also obtain the atmosphere temperature profile using MODIS products derived from NASA, and compare with the sounding data, the results show that they are quite consistent.
GBDT_KgluSite: An improved computational prediction model for lysine glutarylation sites based on Feature Fusion and GBDT classifier

Field: Computer Science (Physical Sciences)

Abstract Background Lysine glutarylation(Kglu) is one of the most important Post-translational modifications(PTMs), which plays significant roles in various cellular functions, including metabolism, mitochondrial processes, and translation. Therefore, accurate identification of Kglu site is important for elucidating protein molecular function. Due to the time-consuming and expensive limitations of traditional biological experiment, computational-based Kglu site prediction research are gaining more and more attention. Results In this study, we proposed a new model named GBDT_KgluSite to identify Kglu and non-Kglu sequences based on the gradient-boosting decision tree (GBDT). Here, sequence-based features, physicochemical property-based features, structural-based features, and evolutionary-derived features were used to characterize proteins. The imbalance between positive and negative samples was addressed using the NearMiss-3 approach, and extraneous data was eliminated using the Elastic Net. The experimental results show that GBDT_KgluSite has good robustness and generalization ability, with accuracy and AUC values of 93.73%, and 98.14% on five-fold cross-validation as well as 90.11%, and 96.75% on the independent test dataset, respectively. Conclusion GBDT_KgluSite is an effectively computational method for identifying Kglu sites in protein sequences. It has good stability and generalization ability and could be useful for the identification of new Kglu sites in Mus musculus protein. The code and dataset of GBDT_KgluSite is available at https://github.com/flyinsky6/GBDT_KgluSite.
Emotional Presence in a Relationship of Inquiry: The Case of One-to-One Online Math Coaching

Field: Psychology (Social Sciences)

Emotions have been confirmed to be a critical component of the process of learning. In the online Community of Inquiry theoretical framework, and the recently suggested online Relationship of Inquiry framework, emotions are considered a subsection of social presence. In this study, the concept of emotional presence is examined. This examination occurs within the Relationship of Inquiry framework, developed to analyze one-to-one online coaching. A survey of online coaches and a transcript coding procedure from the online coaching service Math Coach provide the data for the study. The results indicate that a Relationship of Inquiry framework consisting of cognitive, social, teaching, and emotional presence enhances the exploration of one-to-one online coaching settings. The interpretation of these results identifies emotional presence as an essential and distinct part of one-to-one online math coaching.
Estimating total manoeuvring time of drivers using Gamma distribution function of instantaneous speeds

Field: Engineering (Physical Sciences)

The Total Manoeuvring Time (TMT) of commuting drivers was analyzed by gamma density functions of vehic-le instantaneous speeds and transforming the functions to log normal distributions to determine the cumulative response times. The instantaneous speeds of 50 passenger vehicles were read from the speedometers at non-peak traffic periods on 4 segments of an urban arterial in Ilorin (Nigeria) in 2006. The ages of drivers, service period of vehicles, and pavement conditions were also obtained by interviewing the drivers. A model of cumul-ative response times of driver-vehicle-road interaction developed indicated that TMT was contributed by the interactions of driver perception-reaction time, steering time and vehicle response time in the proportion of 67 %, 22 % and 10 % respectively.
Расчет скоростей на гребнях водосливов-прорезей и дамб затапливаемых польдеров

Field: Engineering (Physical Sciences)

Examined: Rate calculation on crests of weir-openings of drowned polders at arrangement of weir-openings at upper, lower transverse and middle part of longitudinal embankment. Stated: Dependences for approximate calculation of dynamics of levels in drowned polder and rates at weir-opening crest during flood. Proposals are given regarding the procedure of structural design of drowned polder, resistant to washout during flood.
The influence of nasal and oropharyngeal mucosal dysbiosis on the condition of the middle ear in children with congenital cleft palate

Field: Medicine (Health Sciences)

Disturbance of the microbiocenosis of the nasal cavity and oropharynx in children with congenital cleft palate presents serious therapeutic difficulties. Pathobionts colonizing the upper respiratory tract and chronic adenoiditis pose a threat of acute purulent otitis media and chronic otitis media with effusion. The authors studied nasal and oropharyngeal mucosal dysbiosis in patients before elective uranoplasty and the effect of dysbiotic manifestations on the condition of the middle ear in the postoperative period. The results of microbiological examination of 80 swabs from the nasal cavity and oropharynx in patients with congenital cleft palate were analyzed. Among the culture-positive results in patients in clinical and laboratory remission of ENT-infections dysbiosis of 2–3 degrees prevails, the presence of bacterial-bacterial and bacterial-fungal associations is often noted, the predominance of gram-negative microflora is noted. There was an increase in the frequency of perforations of the tympanic membrane in the presence of bacterial and fungal associations, the appearance of retraction pockets in the presence of gram-negative microflora, the relationship between grade 3 dysbiosis and the appearance of purulent otitis media after uranoplasty were revealed. Conclusion . Disturbance of microbiocenosis in patients with congenital cleft palate before uranoplasty requires the inclusion of a microbiological study in the preoperative preparation schedule and a personalized approach to perioperative antibiotic prophylaxis.
Outcomes of solitary dilated breast ducts in symptomatic and asymptomatic patients

Field: Medicine (Health Sciences)

Objective: The purpose of this study is to assess the outcomes of symptomatic and asymptomatic solitary dilated ducts detected on mammography, ultrasound, and MRI. Methods: All cases of isolated solitary dilated ducts between January 1, 2009 and December 31, 2016 in non-lactating females were reviewed. Clinical data, including patient’s age, breast cancer history, and pathology results were collected. Imaging was reviewed, and indication for the exam, breast density, maximum diameter of the dilated duct on ultrasound, presence of an intraductal mass, presence of intraductal vascularity, presence of intraductal echogenicity, and subareolar or peripheral location of the dilated duct were recorded. Results: 87 cases of solitary dilated ducts were assessed in this study, of which 3 were malignant, resulting in a positive predictive value of 3.5% (3/87). No malignancy was identified in asymptomatic screening patients. The three malignant cases were seen in patients presenting with a palpable lump (n = 1) or bloody nipple discharge (n = 2). There was a statistically significant association observed between the dilated duct diameter (p = 0.049) and presence of intraductal vascularity (p = 0.0005) with presence of malignancy. Conclusion: Rate of malignancy is low in solitary dilated ducts, especially among asymptomatic patients. Patient’s presenting with clinical symptoms, larger dilated duct diameters, and/or intraductal vascularity may require additional evaluation including biopsy to exclude malignancy. Advances in knowledge: Clinical and imaging factors can assist in better identifying patients with solitary dilated ducts who should undergo biopsy.
Figure S7 from Auranofin Synergizes with Cisplatin in Reducing Tumor Burden of NOTCH-Dependent Ovarian Cancer

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

<p>Supplementary Figure S7 presents viability assays for platinum-sensitive patient-derived cancer organoids (PDO18, PDXO3, PDO20, replicate PDO20) treated with auranofin ± cisplatin, with data as mean ± SD (n > 5) and one-way ANOVA + Holm–Sidak for synergy (****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05).</p>
Understanding the role of dendritic cells during HIV transmission and latency expansion

Field: Immunology and Microbiology (Life Sciences)

HIV dissemination from the genital mucosal tract to the lymphoid organs is the first critical step towards systemic infection. We and others have previously shown that upon sexual HIV exposure, a local pool of infected cells is found in the genital mucosae, followed by rapid HIV spread into the draining lymphoid tissues before detection in the blood. We extended these observations by addressing the role of DCs in the transfer of HIV particles to susceptible CD4+ T cells through trans-infection. Our laboratory previously showed that CD4+ T cells engaged in prolonged contacts with HIV-bearing DCs that was dependent on gp120:CD4 and LFA-1: ICAM-1 adhesive contacts. Abrogating stable DC: T cell contacts significantly reduced HIV transmission. However, a knowledge gap is a molecular mechanism that facilitates the efficient transfer of HIV through HIV+ DC: T cell contacts. Here, using a custom human kinomics array platform, I identified distinct signaling pathways that are activated in CD4+ T cells during in vitro co-culture with DCs bearing wildtype HIV, but not in HIVEnv. Utilizing functional network analysis programs, such as IPA and InnateDB, I demonstrated that mTOR, ERK, and Ca2+ pathways are upregulated during DC: T cell contacts in the presence of wildtype, but not Env-deficient HIV. These data suggest that T cells accumulate signals downstream of the CD4 molecule that impacts their motility and function as they contact HIV-bearing DCs, some of which are prerequisite for efficient viral infection and ultimately systemic spread.
Frontispiz: Surface Gelation on Disulfide Electrocatalysts in Lithium–Sulfur Batteries

Field: Chemistry (Physical Sciences)

Li-S-Batterien In ihrem Forschungsartikel (e202114671) identifizieren Bo-Quan Li, Qiang Zhang et al. erstmals die Oberflächengelbildung auf Elektrokatalysatoren in Li-S-Batterien.
Determinants of utilisation of risk transfer measures among poultry farmers in Ogun state, Nigeria

Field: Agricultural and Biological Sciences (Life Sciences)

The poultry industry contributes significantly to the development of Nigeria’s economy. Unfortunately, poultry farmers like other farmers are faced with income fluctuations arising from risks associated with the enterprise. In this study, socio-economic characteristics of poultry farmers, different types of risk faced by the poultry farmers, management strategies employed by the poultry farmers for risk reduction; and the determinant of utilization of risk transfer measures were examined. A total of 186 respondents were selected as the sample size using multistage sampling method. The findings revealed that the average age of the poultry farmers was 45 years, Majority of the poultry farmers were male (87.1%), and married (91.4%). The major types of risk faced by the poultry farmers were fluctuation of input price (1.36), mortality of birds (1.35) and incidence of pest and disease (1.31). Furthermore, the study revealed that the management strategies employed by the poultry farmers for risk reduction were access to credit (1.80), timely administration of drugs and vaccines (1.67) and use of modern production techniques (1.54). From the results, it can be concluded that timely administration of drugs and vaccines, use of modern production techniques, income diversification are the common risk management practices among the poultry farmers. The study therefore recommended that poultry farmers should be encouraged to diversify into other viable income generating activities to increase output and reduce shock of failure. Also, adequate institutional poultry farming, utilization, risk.support should be provided to improve productivity
Trends in the Production of Cereals in MP

Field: Agricultural and Biological Sciences (Life Sciences)

Among the food grains, cereals contribute 77.5 per cent and pulses contribute 22.5 per cent in the state. The main cereals are rice, wheat, maize, bajra, barley, jowar and small millets. Madhya Pradesh has about 5 per cent share in the country in the production of cereals, with its production of 83.7 lakh tones. The production of the cereals is increasing continuously in the state since 1951. It has recorded nearly four times increase between 1950-51 and 2002-03, from 21.3 lakh tons to 83.7 lakh tones during the period Wheat ranks first in terms of production (49.23 lakh tones, 59 %) which is also the main crop of Madhya Pradesh. Maize comes second (14.9 lakh tons, 17.8 % and rice third (10.32 lakh tons, 12.32 %) in terms of production. Other important cereals are jowar, barley and small millets, their production was about 9.24 lakh tones, and their share in the cereals was about 11 per cent, in the year 2002-03.
Jaundice in Severe Infections

Field: Medicine (Health Sciences)

can the patient be given a sense of continuity. in the process of treatment.By such means it is also possible to avoid the sudden last-minute urgent admission of a dying patient to a totally strange hospital for the final few hours of a prolonged illness; this is not terminal care but terminal mis- management.If patients are to be trans- ferred for terminal care in geriatric units it is desirable that the prognosis should be assessed in weeks or months rather than days.On the other hand, it must also be acknow- ledged that unexpected remissions can occur when it may be desirable for the patient to return home for a time.There are, among 114 women in this hospital to-day, two cases of carcinoma of breast admitted for " terminal care" 21 months and 32 months ago.If, as Dr. Morton states, the teaching hos- pitals fail to set a good example to their students in managing terminal cases of cancer, this particularly thoughtless form of man's mutual inhumanity will bee perpetuated.-I am, etc.
A Problem-Value-Constraint Framework for Minimizing Under Design and Over Design in Web Service Based System Development

Field: Computer Science (Physical Sciences)

With the increasing of the popularity of Service oriented Software Development, we have identified there is a need to systemically reduce the complexity and increase the robustness of developed Service systems through a guided development process. We choose under design (UD) and over design (OD) as core value assets to uniformly represent the target of managing the human errors and deficiencies during a development process. In the study of a Web Service architectural selection case, based on the ideology of Value Driven Design, we proposed the Problem-Value-Constraint (PVC) approach as the framework of minimizing under design and over design covering both IT concerns including functionalities and qualities and Business concerns including value, cost, price and usage. Our PVC solution connects the characteristics including knowledge management, information transformation and business value. Partially through service design patterns, our study showed that PVC is able to outline both business and technical characteristics at the same time keep the simplicity of model structures.
Distance, Surface, Elsewhere: A Feminist Critique of the Space of Phallocentric Self/Knowledge

Field: Arts and Humanities (Social Sciences)

In this paper I focus on a particular subjectivity and a particular spatiality. The subjectivity is that of dominant Western masculinities. The spatiality is the specific organisation of space through which that subjectivity is constituted and through which it sees the world, a problematic described here as a space of self/knowledge. The importance of a particular organisation of space to this particular subjectivity is introduced through the work of Irigaray, and elaborated with reference to Mulvey's account of the Lacanian mirror stage. Both Mulvey and Irigaray emphasise the importance of a distancing, visualised space to dominant masculinities. However, Mulvey and Irigaray have both been criticised for conceptualising this dominant subjectivity and his visual space in ways which leave little possibility for feminist disruption. These criticisms have been made from a diverse range of theoretical-political positions. In this paper, however, I engage specifically with the visual space of phallocentric space/knowledge, and therefore only explore the critical possibilities offered by other, more recent feminist appropriations of Lacan because these have centred precisely on questions of visuality, spatiality, and subjectivity. In particular, interpretations of Lacan's distinction between a certain organisation of space and what Lacan calls ‘the gaze’ arc drawn upon here in order to theorise both the fragilities of dominant masculinities and the existence of other visualised spaces of self/knowledge. It is thus argued that certain psychoanalytic feminisms can offer a critical account of phallocentric self/knowledge, which is also a critical account of the production of visual spatialities.