jimnoneill/paper-to-field-training huggingface dataset:
Abstract 1202: Targeting PIK3C3 to overcome drug resistance resulted from prosurvival autophagy in cancer cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Autophagy is an important cellular recycling mechanism in which portions of cytosol or organelles are sequestered into a double-membrane structure and delivered to lysosome for degradation. PIK3C3 is the only class III PI3K, which specifically generates phosphatidylinositol 3-phosphate (PtdIns3P). It in turn recruits proteins containing FYVE or PX domains, thereby initiating various complexes at the membranes of endosomes, phagosomes and autophagosomes. Recently, several studies have shown that autophagy is upregulated in cancer cells when exposing to chemotherapy and radiotherapy. Therefore, the rationale of targeting autophagy addiction in cancer was proposed by combining autophagy inhibition with agents that induce autophagy as a pro-survival response to increase their therapeutic efficacy. We stably knocked down PIK3C3 in cancer cell lines and combined with clinical therapeutic agents reportedly induce pro-survival autophagy. Cell viability was examined by MTT assay and combination index was determined by Compusyn software. The autophagy flux was evaluated by detecting protein levels of LC-3II and p62 through western blot analysis. The results showed PIK3C3 knockdown synergistically sensitize the killing effects of gefitinib and gemcitabine in A549 cells and Panc1 cells, respectively. Both of gefitinib and gemcitabine increased autophagy flux, as evidence by the increase of LC3-II and decrease of autophagy substrate, p62. However, the combination of PIK3C3 knockdown and therapeutic agents increased both of the protein levels of LC3-II and p62. These data suggest incomplete autophagy when the function of PIK3C3 was inhibited. The phenomenon was confirmed by bombing autophagy inducer and PIK3C3 inhibitors. Moreover, no appreciable apoptotic cell death was observed. Taken together, our study revealed a potential strategy by targeting PIK3C3 to overcome drug resistance associated with the pro-survival autophagy in cancer. Citation Format: CHUN-HAN CHEN. Targeting PIK3C3 to overcome drug resistance resulted from prosurvival autophagy in cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1202. doi:10.1158/1538-7445.AM2017-1202
The Influence of Hypnotizability and Dissociation on Ganzfeld Experiences and Mind-Wandering

Field: Psychology (Social Sciences)

Many studies have shown that people report unusual experiences when their senses are exposed to unstructured, monotonous stimuli. However, individual differences in responsiveness are poorly understood. The present study used a sensory homogenization procedure (i.e., ganzfeld) to address this issue. High (n = 15) and low hypnotizable individuals (n = 14), also measured on dissociation, completed a mind-wandering task during ganzfeld stimulation and a control condition (in total; 8 males and 21 females, Mage = 22.55, SDage = 4.22). They also retrospectively reported their experiences in reference to each condition. Condition, hypnotizability, and dissociation were expected to interact in terms of mind-wandering and alterations in experiences. Significant interactions were found for the behavioral mind-wandering task, but not for the subjective reports. High hypnotizables engaged more in mind-wandering during ganzfeld stimulation relative to control, whereas lows showed the reverse pattern. These two populations are argued to be a valuable source for the study of different types of mind-wandering.
Metode PjBL: Strategi Pengembangan Modul Ajar Berdiferensiasi untuk Meningkatkan Keaktifan dan Kreativitas Siswa Pada Mata Pelajaran Sejarah

Field: Arts and Humanities (Social Sciences)

This research aims to develop differentiated teaching modules combined with the project-based learning model to increase students' activeness and creativity in participating in history learning at SMA Negeri 1 Gondang Bojonegoro in the chapter on the Hindu-Buddhist maritime kingdoms in Indonesia. The teaching modules developed will be validated by several experts. The results of this research were that the validation value from material experts obtained a percentage of 82.53% with very appropriate criteria, the validation value from media experts was 78.37% so this teaching module was declared valid. Plus, results the attractiveness test from educators obtained a percentage of 86.80% and from students 88.25% so this teaching module was declared attractive. Based on these results, the differentiated teaching module can be declared suitable for use.
Information System Security Analysis of XYZ Company Using COBIT 5 Framework and ISO 27001:2013

Field: Computer Science (Physical Sciences)

Abstract Information system security is now very important to prevent from an attack. Besides that, low level security can harm the productivity of an organization. The purpose of this research is to ascertain and know the level of information system security in XYZ Company, because it has never conducted an audit information system security. In this research, it used the COBIT 5 framework to audit information security management system in a company based on the ISO 27001 standard. This audit was conducted to identify information system security that was not good. In addition to improving the information security management system that will be adjusted to the ISO 27001 standard. This research was composed by applying a qualitative methodology, observation of the activity in the company and reviews related information security management system literature document existing. For the auditing using COBIT 5 framework, audit focuses on four kinds process that consists of APO12, DSS05, MEA02 dan EDM03. The audit COBIT 5 two results in consisting of “Managed Process” Level on APO12, MEA02 and EDM03 and “Performed Process” level on DSS05. The resulting of this research will be used a reference to the improvement of existing information system security in the company.
Speaking to the Spirit of the Games

Field: Social Sciences (Social Sciences)

Chapter Five focuses on the calculated and concerted steps taken by Atlanta’s white business elite and black city government to bid for the Centennial Olympic Games. A diverse cohort of private interests generated the necessary funds to give Atlanta a competitive bid for the Games was formed. This cohort included officers of Atlanta’s fortune 500 companies comprising of the Coca-Cola Company and Delta Airlines, Atlanta businessman Billy Payne, and politicians Mayors Maynard Jackson and Andrew Young. Once awarded the Centennial Games, two movements of paramount importance commenced, representing what the author calls the “olympification” of Atlanta. “Olympification” connotes the policies where urban renewal and gentrification were implemented to get Atlanta ready for the Games. The first of these movements, a joint effort between the United States Olympic Committee (USOC) and the Atlanta Organizing Committee (AOC) worked to prepare the city for the Games is of extreme importance. The second movement, the Atlanta Project, gave way to social change in Atlanta waging war against poverty within the city. Started by the former U.S. president, humanitarian and Georgia native Jimmy Carter, this project had good intentions. But in the end, it did very little for Atlanta’s poor, thus further excluding them from the popular image of Atlanta as black Mecca.
Customers, Boardrooms and Gossip: Theme Repetition and Metapatterns in the Texture of Organizing

Field: Business, Management and Accounting (Social Sciences)

This article draws together theoretical strands from cognitive science, psychoanalysis, and small-group psychology in order to discuss theme repetition in organizations. It suggests that attending to the possibility of theme repetition, even in apparently inconsequential interactions and small talk, can bring to light previously unnoticed connotations of policy or strategy. This discussion leads on to a re-examination and expansion of the notion of metapatterns. These are tacit, emergent patterns of theme repetition in the meanings of organizational contexts. Metapatterns may contribute to enculturation, culture formation and the establishment of organizational stories, histories and artefacts. They may also form a critical obstruction to organizational learning and change. Consequences for researchers and consultants are investigated and it is proposed that, if metapatterns are to alter, recognition of a change agent’s own involvement in metapattern themes is required.
Morphological pattern of the pes tendons in Bennett's Wallaby (Macropus rufogriseus)

Field: Veterinary (Health Sciences)

Abstract Wallabies are small‐ to medium‐sized hopping marsupials and have large and flexible tendons in their hind limbs that act like springs. This study aimed to show the morphological pattern of the pes tendons in Bennett's wallaby. Two Bennett's Wallabies ( Macropus rufogriseus ) that died of natural causes have been used for this study. The pes was dissected using standard dissection techniques to expose the tendons around metatarsals and digits. The crural musculature of the hind limb was also dissected to identify the origin of the tendons. Tendons of m. extensor digitorum longus, m. extensor digitorum lateralis, m. extensor digiti II et III longus, m. flexor digitorum superficialis, m. flexor digitorum profundus and mm. interossei were the main identified tendons. Tendons of m. extensor digitorum longus attached to the distal phalanx of the fourth digit. The tendon of m. extensor digitorum lateralis had two insertion points, on the fourth and the fifth digits. The tendon of m. flexor digitorum superficialis bifurcates at the level proximal one‐third of the metatarsus. The relatively thinner branch inserted into the phalanx of the fifth digit, while the thicker splits and inserted to the medial and lateral surface of the distal end of the proximal phalanx of the fourth digit. Tendon of m. flexor digitorum profundus was the thickest tendon on the plantar surface, and it had four insertion points, which were the distal phalanges of the second, third, fourth and fifth digits. This study provides detailed information for future studies on the biomechanical and functional morphology of tendons in marsupials.
Developmental Biology and Host Plant Range of Rice Earcutting Caterpillar Mythimna separata (Walker)

Field: Agricultural and Biological Sciences (Life Sciences)

This article 'Developmental Biology and Host Plant Range of Rice Earcutting Caterpillar Mythimna separata (Walker)' appeared in the International Rice Research Notes series, created by the International Rice Research Institute (IRRI) to expedite communication among scientists concerned with the development of improved technology for rice and rice-based systems. The series is a mechanism to help scientists keep each other informed of current rice research findings. The concise scientific notes are meant to encourage rice scientists to communicate with one another to obtain details on the research reported.
Money Growth Variability and Stock Returns: An Innovations Accounting Analysis

Field: Economics, Econometrics and Finance (Social Sciences)

This paper employs a seven variable vector autoregression system to analyze the effects of money growth variability on British stock returns using the London share price index. Other variables included in the model are M1 money, budget deficits and surpluses, industrial production, consumer price index, and a long term interest error variance decompositions following Sims (1980). The results of the analysis suggest that money growth variability accounts for 22.82% and 19.53% of the variance of interests rates and stock returns respectively, and hence is considered to be an important influence concerning the and uncertainty associated with returns on investment in stocks and other financial assets.[E44]
Spontaneous and Induced Tumors in Haired and Hairless Strain HR Mice

Field: Medicine (Health Sciences)

Spontaneous and Induced Tumors in Haired and Hairless Strain HR Mice Get access Margaret K. Deringer Margaret K. Deringer National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 2, October 1951, Pages 437–445, https://doi.org/10.1093/jnci/12.2.437 Published: 01 October 1951 Article history Received: 16 July 1951 Published: 01 October 1951
Tamaulipan thornscrub after fire: an analysis of the composition of species

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Forest fires are a natural element in many terrestrial ecosystems, in Mexico one of the main causes of loss of vegetation coverage is related to them. Nevertheless, no research has been carried out in the Tamaulipan thornscrub communities regarding post-fire regenerative strategies of plant species, therefore, is important to generate knowledge about the ecological role of fire in them. The aim of this study is to characterize the arboreal and shrub vegetation of a Tamaulipan thornscrub community in the Northeast of Mexico after a fire. To determine the composition, diversity and structure of the floral community consisting of trees and shrubs, 6 square-shaped sampling sites of 1,600 m2 were established 3 years after the fire. Margalef (DMg), Shannon-Weiner (H’) and Pretzsch (A) indices were calculated to determine the richness, diversity and vertical stratification of species, respectively.23 species, 21 genera and 14 families of vascular plants were registered. The most species were Fabaceae (6) and Rhamnaceae (3) and Cordia boissieri was the specie with greater ecological weight (IVI = 20.3%). The indexes of richness and true diversity (DMg = 3.16; D = 16.44) showed high values, which suggests that the post-fire area has a good regeneration and a high species diversity. With these results we can conclude that the fire is an important agent of change in successional stages of Tamaulipan thornscrub with high values of regeneration after a surface fire.
On the Structure Sensitivity of CO2 Hydrogenation over Cu/ZrO2: Insights into the Role of the Support and the Active Sites

Field: Chemical Engineering (Physical Sciences)

The well-known structure sensitivity of CO2 hydrogenation to methanol has shown to be an impactful topic for the performance of the catalyst and yet remains unaddressed for Cu nanoparticles supported on ZrO2, a material that has shown to be involved in the active site and the reaction mechanism of methanol formation. Herein, Cu/ZrO2 catalysts were studied to unravel the underlying structure¿activity relationships by combining surface and bulk characterization techniques, kinetic measurements, operando-DRIFTS and DFT calculations. Contrary to Cu over inert supports, the results showed different trends and two distinct kinetic regimes. For Cu nanoparticles larger than 2 nm, they are in accordance with previously reported results, this is, a change in the number of active sites, without affecting the nature of them. Conversely, it is demonstrated that the active sites are markedly different over the regime of nanoparticles smaller than 2 nm, accessed for ultralow Cu contents of 0.1 wt %, as evidenced from the systematic change of kinetic parameters and from operando-DRIFTS. The distinct active sites were identified as isolated Cu species (i.e., single atoms and Cu incorporated into the lattice of ZrO2) and highly stable Cu clusters, both of which would allocate the formation of products for low metal contents. The results are certainly related to the interaction between Cu and ZrO2 and unequivocally disclose the relationship between activity regimes and the nature of active sites as a function of the Cu particle size. Furthermore, they demonstrate that distinct active sites can be accessed just by varying the metal content on active reducible supports. As such, the findings are of particular relevance for the fundamental understanding of the interaction between Cu and ZrO2 and its interdependence with the size of the Cu nanoparticles, as well as for the rational design of catalysts for CO2 hydrogenation to methanol.
[Clinical use of the spray-freezing method in ophthalmology].

Field: Medicine (Health Sciences)

The authors describe a therapeutic method using spray freezing in the treatment of malignant tumours of the eyelids and conjunctivae, trichiasis and distichiasis and forms of conjunctivitis vernalis which cannot be checked by drugs. The authors discuss the results assembled in a large group of patients during 1971-1987 (4,084 patients). The results provide convincing evidence that the method is successful in these indications and that it has preference before contact freezing. Treatment of all patients was implemented using the Dresden cryotherapeutic apparatus IKG 3.
Approximation by truncated max‐product operators of Kantorovich‐type based on generalized (ϕ,ψ)‐kernels

Field: Mathematics (Physical Sciences)

Suggested by the max‐product sampling operators based on sinc‐Fejér kernels, in this paper, we introduce truncated max‐product Kantorovich operators based on generalized type kernels depending on two functions ϕ and ψ satisfying a set of suitable conditions. Pointwise convergence, quantitative uniform convergence in terms of the moduli of continuity, and quantitative L p ‐approximation results in terms of a K ‐functional are obtained. Previous results in sampling and neural network approximation are recaptured, and new results for many concrete examples are obtained.
Studies on Marsupial Reproduction. 1. General features and techniques.

Field: Agricultural and Biological Sciences (Life Sciences)

Previous work on the reproduction of marsupials is mentioned briefly and the taxonomy of Setonix brachyurus Quoy and Gaimard, the animal chosen for this investigation, is discussed. The feeding in captivity, surgery, methods of taking vaginal smears, and histological methods are described. Anatomically the reproductive system of Setonix is similar to that of other marsupials. There are two ovaries, two uteri, and two lateral vaginae. The vaginal culs-de-sac are connected to the urogenital sinus, forming a pseudo-vaginal canal which remains open after the birth of the first young. The reproductive system differs from that of the true kangaroos and resembles that of the rat kangaroos in possessing an anterior vaginal expansion. Some preliminary observations on breeding are recorded, with some details of growth rates, feeding, etc. of pouch young.
Use of negative pressure wound therapy during aeromedical evacuation of patients with combat-related blast injuries.

Field: Health Professions (Health Sciences)

The purpose of the study was to evaluate safety and feasibility of negative pressure wound therapy (NPWT) during aeromedical evacuation from a combat zone to a regional treatment center. A retrospective review of patients who received NPWT during aeromedical evacuation from Iraq or Afghanistan to Landstuhl Regional Medical Center (LRMC) was performed. Data were collected describing mechanism of injury; anatomic site of NPWT application; number of sites per patient; date and time of NPWT application; date, time, and wound condition on arrival and inspection at LRMC; and complications encountered during aeromedical evacuation. Broad definitions of complications were employed. Any reported malfunction of NPWT devices or need to reinforce NPWT dressings was abstracted. Presence of tissue under the dressing requiring debridement was defined as a minor complication. Major complications were defined as wound sepsis with systemic manifestations. A total of 218 patients who had received NPWT for 298 wounds (1.37 per patient) during aeromedical evacuation were identified. Most wounds were due to high-energy blast or ballistic mechanisms. Average time from NPWT application to removal was 53 hours (range, 18-133 +/- 22 hours). Complications occurred at 14% of NPWT sites and in 19% of patients receiving NPWT. Most recorded complications were minor (95%). Two patients who arrived at LRMC with fever and evidence of wound sepsis improved rapidly after additional operative debridement. In no case was failure of the NPWT device in flight specifically implicated in the genesis of a recorded complication. In-flight device problems were identified in seven cases. Four of these could not be repaired in flight and were clamped. Complications were not increased in this cohort. Use of NPWT during aeromedical evacuation appears safe and feasible in a large cohort of patients with high-energy injuries. Complications were consistent with severity of injury and not related to failure of NPWT.
The Role of Women in Revolutionary Movements: A Comparative Analysis of the French, American, and Mexican Revolutions

Field: Arts and Humanities (Social Sciences)

In the past, historical accounts have often excluded the contributions of women to revolutionary movements, focusing primarily on male figures and perspectives. However, recent scholarship has begun to uncover the significant and multifaceted roles that women played in shaping revolutionary events. This research has prompted a reevaluation of traditional narratives and highlighted the need for a more inclusive approach to understanding revolutions. This study seeks to address this gap by conducting a comparative analysis of women's participation across three pivotal revolutions: the French, American, and Mexican Revolutions. By examining primary sources, historical documents, and academic literature, the research aims to explain the diverse ways in which women engaged with and influenced revolutionary processes. Through qualitative methodologies, such as narrative analysis and thematic coding, the study will explore the motivations, challenges, and strategies employed by women in their revolutionary endeavors. Furthermore, the comparative approach will discuss the differences in women's experiences across different revolutionary contexts. By uncovering patterns of participation and leadership, the research aims to provide insights into the broader dynamics of gender and power within revolutionary movements. Ultimately, this research is sought to contribute to a more nuanced understanding of revolutions by focus the agency and contributions of women. By showcasing their voices and stories, the study seeks to explore historical narratives and promote greater recognition of women's roles in shaping revolutionary trajectories.