jimnoneill/paper-to-field-training huggingface dataset:
Activation of the erythropoietin promoter by a point mutation from GATA to TATA in the -30 region.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

We show here a role of the highly conserved GATA motif in the -30 region of the erythropoietin (Epo) promoter. Epo production is reduced in normoxia and activated in hypoxia to control the oxygen supply through erythropoiesis. Although the hypoxic inducibility has been analyzed, the molecular mechanism for the low basal activity in normoxia remained unclear. The GATA motif in the -30 region upstream of the transcription initiation site is highly conserved among the species. In many genes, the consensus motif in the -30 region is TATA. The GATA motif of the Epo promoter was mutated to TATA. The transcriptional activity of the mutant was enhanced even in normoxia. Binding assays showed that TATA-binding protein (TBP) could weakly bind to the wild-type GATA motif whereas TBP bound to the mutant TATA motif with high affinity. These results indicate that the highly conserved GATA motif in the -30 region of the Epo promoter can avoid binding and activation by TBP. This evidence is considered to be the molecular basis for the low physiological expression from the Epo promoter in normoxia.
Memsahib to missus: transcolonial constructions of the female domestic service relationships in India and Australia

Field: Social Sciences (Social Sciences)

In the late 1850s, a young woman, orphaned as a child in India under the Raj, ran away from unsympathetic guardians in Scotland to the British colony of New South Wales, where she successfully re-invented herself, in relation to Aboriginal people, as a classic 'little missus'. This paper takes her colonial trajectory as the starting point for an exploration into the construction of respectable white womanhood under British colonization. Drawing upon the approach taken by Ann Laura Stoler in her discussion of the emotional economy of colonial memories of the beloved and nurturing servant, it suggests that such a transcolonial construction was dependent upon the figure, particularly, of the native female nursemaid. Furthermore, it argues that the Indian ayah, as she was imagined in Anglo-colonial culture from the late nineteenth century, would provide a template for the ‘fashion' of engaging young Indigenous women as maids in both Australia and the United States in the first half of the twentieth century. As this practice was inextricably bound up with the destruction of Aboriginal Australian and Native American communities, the links between imperial practice in South-East Asia and settler colonial practice in the modernizing ex-colonial nations highlight the roots of contemporary female domestic service relationships in colonialism and dispossession.
Complications;

Field: Medicine (Health Sciences)

Rare pulmonary complications after transarterial chemoembolisation for hepatocellular carcinoma: two case reports We report two rare cases of acute pulmonary complication after transarterial chemoembolisation for inoperable hepatocellular carcinoma. Both cases involved a large tumour and hepatic vein invasion. The first patient, a 27-year-old man, died of pulmonary tumour embolism 4 days after transarterial chemoembolisation. Acute dyspnoea developed in the second patient, a 63-year-old man, following the procedure due to pulmonary oil embolisation and chemical pneumonitis. The chest condition of this patient improved, but he subsequently died of liver failure 3 weeks later. Our cases illustrate the point that if locoregional treatment is offered as a palliative treatment, patients with hepatic vein invasion should be warned of the possible complications of massive tumour embolism, pulmonary oil embolisation, and subsequent death. !&quot;#$%&amp;&apos;()&apos;*+,-./01234562789:;&lt;&amp;.=
Effect of Sulfation on the Conformational Dynamics of Dermatan Sulfate Glycosaminoglycan: A Gaussian Accelerated Molecular Dynamics Study

Field: Chemistry (Physical Sciences)

Glycosaminoglycans (GAGs) are anionic biopolymers present on cell surfaces as a part of proteoglycans. The biological activities of GAGs depend on the sulfation pattern. In our study, we have considered three octadecasaccharide dermatan sulfate (DS) chains with increasing order of sulfation (dp6s, dp7s, and dp12s) to illuminate the role of sulfation on the GAG units and its chain conformation through 10 μs-long Gaussian accelerated molecular dynamics simulations. DS is composed of repeating disaccharide units of iduronic acid (IdoA) and N-acetylgalactosamine (N-GalNAc). Here, N-GalNAc is linked to IdoA via β(1-4), while IdoA is linked to N-GalNAc through α(1-3). With the increase in sulfation, the DS structure becomes more rigid and linear, as is evident from the distribution of root-mean-square deviations (RMSDs) and end-to-end distances. The tetrasaccharide linker region of the main chain shows a rigid conformation in terms of the glycosidic linkage. We have observed that upon sulfation (i.e., dp12s), the ring flip between two chair forms vanished for IdoA. The dynamic cross-correlation analysis reveals that the anticorrelation motions in dp12s are reduced significantly compared to dp6s or dp7s. An increase in sulfation generates relatively more stable hydrogen-bond networks, including water bridging with the neighboring monosaccharides. Despite the favorable linear structures of the GAG chains, our study also predicts few significant bendings related to the different puckering states, which may play a notable role in the function of the DS. The relation between the global conformation with the micro-level parameters such as puckering and water-mediated hydrogen bonds shapes the overall conformational space of GAGs. Overall, atomistic details of the DS chain provided in this study will help understand their functional and mechanical roles, besides developing new biomaterials.
Idiopathic Central Serous Retinopathy in China: A Report of 600 Cases (624 Eyes) Treated by Acupuncture

Field: Medicine (Health Sciences)

ABSTRACT Six hundred Chinese patients (624 eyes) with clinically diagnosed central serous retinopathy were treated by consecutive courses of acupuncture. Eighty-six percent of patients had resolution of their subretinal fluid within 3 months of treatment, a result similar to the natural history of the disease as reported by others in non-Chinese patients. Central serous retinopathy was most common in the 30 to 50 year age group, occurred in males seven times more frequently than in females, and was bilateral in 4% of patients.
STRATEGIES EMPLOYED BY PRE-SERVICE TEACHERS TO COPE WITH THE STRESS INDUCED BY PUBLIC PERSONNEL SELECTION EXAM (KPSS)

Field: Psychology (Social Sciences)

This study was carried out using the scanning method in order to detect the methods of coping with stress that occurs due to the public personnel selection examination (KPSS) of pre-service teachers studying at state universities in Turkey. Data was gathered using a Scale of Effect of Stress on Performance. Analysis was based on frequency, percentages, arithmetic mean, chi-square and t-test. Pre-service teachers apply these methods of coping with stress at medium level: âtrying not to think about the situation causing stress, disregarding, dealing with the situation or event, thinking that it may be worse, meeting with the family members and friends, watching cultural and sportive activities, acting in the field they are talented, shopping, praying.â It was found that there is no meaningful relationship between the coping with stress and gender, education institutions, education statues, family incomes and university pleasure; there is a meaningful relationship between the coping with stress and age, monthly income of family, adequacy of equipment, field pleasure, internet usage and branch assignation of M.E.B. (Ministry of National Education).
Innocent Victims: Poetic Injustice in Shakespearean Tragedy.

Field: Arts and Humanities (Social Sciences)

Journal Article R. S. White. Innocent Victims: Poetic Injustice in Shakespearean Tragedy.R. S. White. Let Wonder Seem Familiar: Endings in Shakespeare’s Romance Vision. Get access Innocent Victims: Poetic Injustice in Shakespearean Tragedy. By R. S. White. London: The Athlone Press, 1986. Pp. ix + 149. $25.00 cloth.Let Wonder Seem Familiar: Endings in Shakespeare’s Romance Vision. By R. S. White. Atlantic Highlands, N.J.: Humanities Press; London: The Athlone Press, 1985. Pp. 203. $23.50 cloth. Larry S. Champion Larry S. Champion Search for other works by this author on: Oxford Academic Google Scholar Shakespeare Quarterly, Volume 38, Issue 3, Autumn 1987, Pages 379–381, https://doi.org/10.2307/2870516 Published: 01 October 1987
A Broadband ML-FMA for 3-D Periodic Green’s Function in 2-D Lattice Using Ewald Summation

Field: Computer Science (Physical Sciences)

A periodic fast multipole algorithm (P-FMA) is devised for evaluating 3-D periodic Green's function (PGF) for a 2-D lattice which can be used to solve scattering by a structure with 2-D periodicity. The introduction of periodicity in the Green's function formulation produces image sources at each lattice site. Like multilevel FMA (ML-FMA), P-FMA takes advantage of the distance between image sources and observation points to factorize the field using multipoles. By substituting known factorizations of the free-space Green's function into the expression for PGF, one can isolate the summation over the lattice into the translation phase of the FMA. For both plane wave and multipole factorizations, a common term known as lattice constant appears. The lattice constant is an infinite sum over the lattice which does not converge absolutely when expressed as a spatial sum. Using the Ewald summation technique, the lattice constants can be evaluated with exponential convergence and high accuracy. The resulting P-FMA is between O(N) and O(N log N) in memory use and computational complexity, depending on the object size relative to the wavelength.
Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo

Field: Neuroscience (Life Sciences)

Several studies suggest that axonal projections from the hippocampal formation (HF) to the basolateral amygdala (BLA) play a role in Pavlovian fear conditioning to contextual conditional stimuli. We have used electrophysiological techniques to characterize neuronal transmission in these projections in urethane-anesthetized rats. Single- pulse electrical stimulation of the ventral angular bundle (VAB), which carries projections from the HF to the BLA, reliably evoked a biphasic extracellular field potential in the BLA that consisted of an early, negative and a late, positive component. The negative component of the field potential occurred at a short latency (3–8 msec), was both temporally and spatially correlated with VAB-evoked multiple-unit discharges in the BLA, and exhibited properties typical of a monosynaptic response. Infusion of lidocaine or glutamate receptor antagonists into the BLA attenuated VAB-evoked field potentials, indicating that they are generated by local synaptic glutamatergic transmission. Both paired-pulse stimulation and brief trains of high- frequency stimulation (HFS) induced a short-lasting facilitation of BLA field potentials, whereas longer and more numerous trains of HFS produced an enduring, NMDA receptor-dependent long-term potentiation (LTP) of the potentials. The induction of LTP was accompanied by a decrease in paired-pulse facilitation (PPF), suggesting a presynpatic modification underlying its expression. Electrolytic lesions placed in regions of the HF that project to the BLA or excitotoxic lesions placed in the BLA eliminated Pavlovian fear conditioning to a contextual conditional stimulus. The critical role of both structures in context conditioning implicates plasticity at HF-BLA synapses in this form of learning.
Effects of DISCOVER on the Career Maturity of Middle School Students

Field: Psychology (Social Sciences)

This study evaluated the effects of DISCOVER (American College Testing [ACT], 1991), a computer‐assisted career guidance system, on the career maturity of 38 students (22 girls and 16 boys) enrolled in a rural middle school. Students randomly assigned to the treatment group worked with DISCOVER for approximately 1 hour a day over a 2‐week period, whereas students in the control group did not have access to the DISCOVER program. Results indicated significant gains in career maturity among students in the treatment group ( p <.05).
Investigation on residual hearing and audio-speech recovery in 229 deaf-mute children

Field: Medicine (Health Sciences)

An investigation and analysis of 229 deaf-mute children revealed that 54.2% of acquired deafness were caused by ototoxic aminoglycoside drugs. There is an upward trend of the occurrence of the disease in the recent years and more attention should be paid to it. The result of pure tone audiometry shows that more than 904% of deaf-mute children had residual hearing. Twenty-six deaf-mute children whose average hearing thresholds of speech frequency were better than 90 dB (HL) had serviceable speech for daily use. After 3 to 18 months' speech training, 4 of them were transferred to public primary school. The authors are of the opinion that the deaf-mute children should use hearing-aids as early as possible so as to promote their speech.
Supplementary Video 7 from Analysis of Mitosis and Antimitotic Drug Responses in Tumors by <i>In Vivo</i> Microscopy and Single-Cell Pharmacodynamics

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Supplementary Video 7 from Analysis of Mitosis and Antimitotic Drug Responses in Tumors by <i>In Vivo</i> Microscopy and Single-Cell Pharmacodynamics
Consumer Preference in Selecting Broiler Meat in the Traditional Market Subdistrict Kampar, Kampar District, Riau Province

Field: Arts and Humanities (Social Sciences)

Among consumers have different decision in choosing meat broiler.This study aims to know segments potential meat broiler consumers, preference of consumers in choosing meat broiler and find the factors that affecting the amount of meat broiler consumpsion in traditional markets in subdistrict Kampar Province of Riau.The primary data was obtained by interviewing 90 respondents using questionaire.Descriptive analysis and regression analysis were used to analyse data.Variable observed is respondents profile, attribute chicken and the factors that affecting the amount of consumption.This research result indicates segments potential meat broiler consumers in traditional markets in Subdistrict Kampar is a female, who has range age 30-40 years, having 3-5 family numbers with the level of high school education, senior high school or equivalent background and have a job as a farmer.Attribute chicken broiler trade which became preference of consumers in traditional markets Subdistrict Kampar, the price of affordable they can bargain, nutrition content high, cleanliness meat, smell, color fresh and texture chicken broiler spongy.While the factors that affecting the amount of their consumption of meat broiler chicken in traditional markets Subdistrict Kampar are the price of meat broiler, the number of family members and price other meat.Factor income is not significant influence consumption where factors the number of family members and price other meat have had a positive impact on the number of consumption.While factors the price of meat broiler itself has negative effects on the number of their consumption of meat broiler chicken.
General one-sided Clifford Fourier transform, convolution products in the spatial and frequency domains, and auto-correlation theorems

Field: Mathematics (Physical Sciences)

In this paper we use the general steerable one-sided Clifford Fourier transform (CFT), and relate the classical convolution of Clifford algebra-valued signals over R^{p;q} with the (equally steerable) Mustard convolution. A Mustard convolution can be expressed in the spectral domain as the point wise product of the CFTs of the factor functions. In full generality do we express the classical convolution of Clifford algebra signals in terms of a linear combination of Mustard convolutions, and vice versa the Mustard convolution of Clifford algebra signals in terms of a linear combination of classical convolutions. Finally, we derive auto-correlation theorems for the cross-correlation and for the auto-correlation of Clifford signals.
Good Without God? Connecting Religiosity, Affiliation And Pro-sociality Using World Values Survey Data And Agent-based Simulation

Field: Social Sciences (Social Sciences)

We investigate the relationships among individuals' religiosity (or secularity), affiliation with like-minded religious others, volunteerism, and trust and tolerance. Using data analysis of the World Values Survey, we pose and answer research questions about the types of individuals who are the most trusting, the most tolerant, and who volunteer the most. We show how distinguishing between different types of volunteer activities and using longitudinal data can provide more insight into these questions. We also use an established agent-based model to generate measures similar to those operationalized in the World Values Survey. We then reproduce the findings of the World Values Survey data analysis and extract the internal dynamics of simulation experiments (under a reasonable parameterization of the model) to provide an explanation for those findings.
Combined Psoas Compartment-Sciatic Block in a Pediatric Patient with High-Risk Cardiopulmonary

Field: Health Professions (Health Sciences)

There is high potential for complications in cardiopulmonary high-risk patients with valvular heart disease at perioperative period. The operation was planned due to pathological fracture of the femoral shaft of a nine year old male patient weighing 26 kilograms. He had 3o tricuspid insufficiency, 3o mitral insufficiency and pulmonary hypertension in preoperative evaluation. Sciatic nerve block and psoas compartment block was performed to patient for anesthesia and analgesia. In conclusion we think that combined psoas compartment-sciatic nerve block may be a good alternative to other methods of anesthesia in high-risk pediatric patients with cardiopulmonary perspective in lower-extremity surgery.
[Thyroid carcinoma and the recurrent nerve. Recurrence fall-out, incidence and causal circumstances in a large case-load of patients with thyroid carcinoma].

Field: Medicine (Health Sciences)

Impairment of vocal cord function is a threat to patients with thyroid carcinoma; either due to the tumor having infiltrated the larynx or the recurrent nerve, or to accidental damage to the laryngeal nerves during thyroid surgery. We have reviewed 1,245 patients' records which were filed under the diagnosis of thyroid carcinoma at Det Norske Radiumhospital from 1956 to 1978. Pareses of vocal cords were noted in 465 patients (37.3%) during the course of their illness. In 135 patients (10.8%) the pareses were due to infiltration by the tumor, most commonly seen in anaplastic carcinoma. In 267 patients (21.4%) the pareses followed surgery; planned resections of the recurrent nerves were performed in 48 patients (3.9%). Transient pareses with normal vocal cord movements within months were experienced in 137 cases (11%). Permanent paralysis caused accidentally during surgery was seen in 82 patients, representing 6.6% of all patients and 4.7% of the surgically exposed nerves. We stress the need for pre- and postoperative evaluation of vocal cord movement as an aid to future diagnosis and optimal surgical planning.
Benefits of security-informed safety-oriented process line engineering

Field: Engineering (Physical Sciences)

Nowadays, given the growing aircraft connectivity, security-informed safety is crucial. To certify aircrafts, safety as well as security standards need to be taken into consideration. In this context, a process engineer has to succeed in mastering the growing complexity of the standards interplay. To support process engineers, we propose to: first, consider a common terminological framework, aimed at reconciling security and safety within dependability; then identify and systematize commonalities and variabilities between the processes. To enable this systematization we introduce Security-informed Safety-oriented Process Line Engineering (SiSoPLE), which extends SoPLE to address security concerns. To show the effectiveness and benefits of SiSoPLE, we apply this new process line engineering to two aerospace standards, SAE ARP 4761 (Safety) and RTCA DO-326A (Security). We then provide our lessons learned and concluding remarks. Finally, we sketch some perspectives for future investigation.
ERIC ED213517: Bilingual Multicultural Education: Issues, Research, Rationale.

Field: Social Sciences (Social Sciences)

Issues related to the future of bilingual education are discussed in this brief paper. Points of controversy concerning bilingual education are pointed out and three philosophical approaches to, or models for, bilingual education are briefly described. The view of critics who see bilingual education as educationally unsound are mentioned and data about the educational experience of culturally diverse populations in the United States are introduced as part of an argument that a return to past practices requiring cultural assimilation is not a justifiable policy. It is further argued that such traditional educational practices violate basic American principles of freedom and human rights. Research findings countering the view that bilingualism is an outward sign of poor intellectual functioning are cited. Additional studies, indicating the positive outcomes of bilingual abilities and programs, are cited and briefly described, and it is concluded that the growth of the Hispanic population necessitates the attainment of some semblance of equal educational opportunity. (Author/RH)
Broad-Based Nutritional Supplementation in 3xTg Mice Corrects Mitochondrial Function and Indicates Sex-Specificity in Response to Alzheimer's Disease Intervention

Field: Neuroscience (Life Sciences)

Nutrition has been highlighted as a potential factor in Alzheimer's disease (AD) risk and decline and has been investigated as a therapeutic target. Broad-based combination diet therapies have the potential to simultaneously effect numerous protective and corrective processes, both directly (e.g., neuroprotection) and indirectly (e.g., improved vascular health). Here we administered either normal mouse chow with a broad-based nutritional supplement or mouse chow alone to aged male and female 3xTg mice and wildtype (WT) controls. After approximately 4 months of feeding, mice were given a battery of cognitive tasks and then injected with a radiolabeled glucose analog. Brains were assessed for differences in regional glucose uptake and mitochondrial cytochrome oxidase activity, AD pathology, and inflammatory markers. Supplementation induced behavioral changes in the 3xTg, but not WT, mice, and the mode of these changes was influenced by sex. Subsequent analyses indicated that differential response to supplementation by male and female 3xTg mice highlighted brain regional strategies for the preservation of function. Several regions involved have been shown to mediate responses to steroid hormones, indicating a mechanism for sex-based vulnerability. Thus, these findings may have broad implications for the human response to future therapeutics.
Ultra-thin g-C3N4/MFM-300(Fe) heterojunctions for photocatalytic aerobic oxidation of benzylic carbon centers

Field: Chemistry (Physical Sciences)

In situ growth of the MFM-300(Fe) on an ultra-thin sheet of graphitic carbon nitride, formed by exfoliation using supercritical CO2, is reported. The resultant composite CNNS/MFM-300(Fe) shows excellent performance in photocatalytic aerobic oxidation of benzylic C–H groups.