jimnoneill/paper-to-field-training huggingface dataset:
Eye Gaze Differences in School Scenes Between Preschool Children and Adolescents With High-Functioning Autism Spectrum Disorder and Those With Typical Development

Field: Psychology (Social Sciences)

Abstract Children with autism spectrum disorder (ASD) sometimes find it difficult to adapt to the daily life in a nursery or at school. For a better understanding on the difficulties that preschool children and adolescents with ASD face in their daily lives, this study aimed to identify the differences in eye gaze behavior in the classroom environment between children with ASD and those with typical development (TD). A total of 30 children with ASD and 49 children with TD were included. We presented images of a human face and a classroom setting and used eye tracking with an iView X system in evaluating and comparing how long the two groups gazed at specific regions of the visual stimuli. Compared to children with TD, children with ASD spent less time gazing at the eyes of the human face and the object pointed by the teacher in the school classroom scene. Preschool children with no classroom experience and adolescents with TD spent the same amount of time looking at the eyes and the object pointed by the teacher in the school classroom scene. Children with ASD did not look at the eyes in the facial image or the object pointed at in the classroom image, which might indicate their inability to analyze situations, understand instruction in a classroom, or act appropriately in a group. An educational program that focuses on joint attention in a classroom is desirable for the improvement of school life for children with ASD.
Antimicrobial Therapy

Field: Medicine (Health Sciences)

Due to the high number of complicated and difficult to treat infections in critical care units, in-depth knowledge of antimicrobial agents is required. In choosing empiric antimicrobial therapy, the clinician must consider the most likely site and organism responsible for the infection, in addition to hospital susceptibility data, potential adverse effects, cost effectiveness, and recent antibiotic exposure. Antimicrobial stewardship programs have become the modern approach to optimizing the administration of antimicrobials through appropriate selection, dosing, monitoring, reassessment, and de-escalation. This chapter presents guidelines regarding the empiric selection of antimicrobials for the most common infections based on the most likely organism responsible for the infection. Understanding the basic clinical pharmacology of antimicrobials will help guide therapy.
Clinical outcomes in patients with BRAFV600 mutant melanoma and undetectable circulating tumor DNA treated with dabrafenib and trametinib.

Field: Medicine (Health Sciences)

10059 Background: Circulating tumor DNA (ctDNA) analysis has been promoted as a less-invasive surrogate assay for tumor-tissue based tumor oncogene analysis. Here, we associate detection of BRAF mutant ctDNA with PFS and OS in patients with tissue-confirmed BRAF V600 mutant melanoma enrolled in S1320, a randomized phase 2 clinical trial of continuous versus intermittent dosing of dabrafenib and trametinib. Methods: Patients with BRAF V600 melanoma received continuous therapy with dabrafenib and trametinib for 8 weeks after which patients were randomized 1:1 to proceed with intermittent treatment on a 3-week-off, 5-week-on schedule or to continue with continuous therapy. Pre-treatment blood samples were interrogated using the Guardant 360 ctDNA assay for all exons of 30 known oncogenes including BRAF and for all exons with known oncogenic mutations in the COSMIC database in 40 additional oncogenes. Clinical responses were assessed at 8-week intervals by RECIST v1.1 and PFS and OS estimates were compared using log-rank test in patients with detectable versus undetectable BRAF V600 mutant ctDNA,. Results: Somatic BRAF V600E or BRAF V600K ctDNA was detected in 34 of 50 patients with baseline (before lead-in cycle 1) blood samples available for analysis including 16 of 23 (70%) patients randomized to continuous dosing, 15 of 21 (71%) randomized to intermittent dosing, and 3 of 6 (50%) who were not randomized due to disease progression at 8 weeks or other factors. Four additional patients had other detectable somatic mutations but no detectable BRAF V600 ctDNA at baseline, and 12 patients had no detectable somatic ctDNA mutations at baseline. Detection of BRAF V600 ctDNA was associated with baseline disease stage (p = 0.008). There was no difference in the overall response rate based on baseline ctDNA detection. Detection of ctDNA at baseline was associated with worse PFS (median BRAF V600 ctDNA positive = 5.8; 95% CI: 4.2-9.6 months, BRAF V600 ctDNA negative = 21.4 mos; 95% CI 10.4-NA; measured from registration to lead-in cycle 1, p = 0.001) and OS (BRAF V600 ctDNA positive = 17.8 mos; 95% CI 9.76-NA, BRAF V600 ctDNA negative = not reached; 95% CI NA-NA, p = 0.0021). Conclusions: The absence of detectable BRAF V600 ctDNA at baseline is associated with improved PFS and OS in patients receiving treatment with dabrafenib and trametinib. Clinical trial information: NCT02196181.
Early Palaeolithic in South and East Asia. Edited by Fumiko Ikawa-Smith (World Anthropology Series, general editor, Sol Tax). Mouton Publishers: the Hague, Paris, 1978. Pp. 389 + XII, line drawings (no price given).

Field: Arts and Humanities (Social Sciences)

Early Palaeolithic in South and East Asia. Edited by Fumiko Ikawa-Smith (World Anthropology Series, general editor, Sol Tax). Mouton Publishers: the Hague, Paris, 1978. Pp. 389 + XII, line drawings (no price given). - Volume 14 Issue 3
Product and process parameters determination for quality and cost

Field: Decision Sciences (Social Sciences)

The purpose of this study is to conduct a concurrent product and process parameters determination for further cost reduction and quality enhancement. The process design-related parameters, such as process mean, process tolerance and product design-related parameters, such as product tolerance, are considered simultaneously in the proposed approach. To reflect the response from these three key controllable characteristics: process mean, process tolerance and product tolerance, the key measurement score, which is the sum of the mean cost, tolerance cost, quality loss and failure cost, is used to evaluate the present model. Two examples are provided for demonstrating the application of single and multiple quality characteristics.
Speech emotion recognition with TGI+.2 classifier

Field: Computer Science (Physical Sciences)

We have adapted a classification approach coming from optical character recognition research to the task of speech emotion recognition. The classification approach enjoys the representational power of a syntactic method and efficiency of statistical classification. The syntactic part implements a tree grammar inference algorithm. We have extended this part of the algorithm with various edit costs to penalise more important features with higher edit costs for being outside the interval, which tree automata learned at the inference stage. The statistical part implements an entropy based decision tree (C4.5). We did the testing on the Berlin database of emotional speech. Our classifier outperforms the state of the art classifier (Multilayer Perceptron) by 4.68% and a baseline (C4.5) by 26.58%, which proves validity of the approach.
ROLE OF AYURVEDA IN MANASA VYADHI

Field: Medicine (Health Sciences)

Introduction: Ayurveda, a holistic science, deals with physical and mental well-being. As in Samhitas, it is mentioned that “Dosha dhatu malamulam hi Shariram” means these three are the root of the human body. When it is in an equilibrium state, it makes an individual healthy; when it gets disturbed, it causes diseases. This dis-ease may affect physical as well as mental state. Factors responsible for any disease are Mithya, Ati, and Ayoga of Kala, Buddhi, and Indriya. Satva represents Manas’s constitution; it governs psychic and psycho-somatic manifestations. The psychological and psychosomatic disorders mainly arise due to the improper functioning of Manas. Manasa Roga is also associated with lifestyle patterns and social behaviour. The balancing state of Satva helps to cure Manasa Roga, and this state can be achieved by following the rules of Ahara, Vihara, Pathya, and Apathya. The spiritual well-being or moral conduction helps to establish balances of Manas, thus restricting the pathogenesis of Manasa Roga. Ayurveda advised Daivavyapashraya Chikitsa, Yuktivyapashraya Chikitsa, and Satwavajaya Chikitsa to balance Satva guna and emotional factors responsible for mental illness. Methods: Various Samhitas, Textbooks, Internet, etc. Result: Nowadays, socialisation and a busy lifestyle lead to increasing Stress and anxiety, which causes Manasa Vyadhi. As Ayurveda says, your body and mind should be balanced to be healthy. Hence, in this paper, we tried to elaborate on the etiopathogenesis of Manasa Vyadhi and its treatment as per Ayurveda. Discussion: As Ayurveda is a science of ancient times and consists of overall well-being, i.e. Physical as well as mental, and in various Samhitas, detailed description of mana and their Mano Bhava are given. Various fac-tors affect Mano bhava and lead to disease. Various treatments are followed to cure this type of disease.
Comparison of Venous Return Characteristics with Right Ventricular Mechanics During Cephalic Fluid Shift

Field: Medicine (Health Sciences)

For my summer internship project, I organized a pilot study to analyze the effects of a cephalic fluid shift on venous return and right ventricular mechanics to increase right ventricular and venous knowledge. To accomplish this pilot study, I wrote a testing protocol, obtained Institutional Review Board (IRB) approval, completed subject payment forms, lead testing sessions, and analyzed the data. This experiment used -20deg head down tilt (20 HDT) as the ground based simulation for the fluid shift that occurs during spaceflight and compared it to data obtained from the seated and supine positions. Using echocardiography, data was collected for the right ventricle, hepatic vein, internal jugular vein, external jugular vein, and inferior vena cava. Additionally, non-invasive venous pressure measurements, similar to those soon to be done in-orbit, were collected. It was determined that the venous return from below the heard is increased during 20 HDT, which was supported by increased hepatic vein velocities, increased right ventricular inflow, and increased right ventricular strain at 20 HDT relative to seated values. Jugular veins in the neck undergo an increase in pressure and area, but no significant increase in flow, relative to seated values when a subject is tilted 20 HDT. Contrary to the initial expectations based on this jugular flow, there was no significant increase in central venous pressure, as evidenced by no change in Doppler indices for right arterial pressure or inferior vena cava diameter. It is suspected that these differences in pressure are due to the hydrostatic pressure indifference point shifting during tilt; there is a potential for a similar phenomenon with microgravity. This data will hopefully lead to a more in-depth understanding of the response of the body to microgravity and how those relate to the previously mentioned cardiovascular risk of fluid shift that is associated with spaceflight. These results were presented in greater detail to the Cardiovascular Laboratory and the Space Life Science Summer Institute, which helped me prepare for future graduate school research presentations. This internship allowed me to apply and expand the anatomy, physiology, and mechanics information I learned during my undergraduate degree in Biomedical Engineering to the cardiovascular system with the unique zero gravity perspective. Additionally, I was able to develop skills with data analysis techniques involving speckle tracking for ventricular strain and Doppler waveforms for blood velocities. Additionally, I was able to expand upon my previous work in the Cardiovascular Laboratory by writing a literature review on a data analysis project I completed last summer. Ultimately, this internship and venous relationship comparison project provided me with a significant learning experience and additional skill sets, which are applicable to my goals of attaining a Ph.D. in biomedical engineering with a focus on tissue engineering and the cardiovascular system.
Predicting nursing students' psychological well-being: network analysis based on a model of thriving through relationships

Field: Psychology (Social Sciences)

Psychological well-being plays a vital role in nursing students' mental health and affects their decisions to stay in the nursing profession, particularly during the COVID-19 outbreak. Close relationships are undeniably linked to psychological well-being, but it is unknown how the specific pathways through which close relationships are related to each other and which are most strongly linked to nursing students' psychological well-being.To explore the network structure, central and bridge factors among well-being characteristics, and predictors based on a model of thriving through relationships.A cross-sectional research design was used with a sample of undergraduate nursing students (531 participants from the Southwest part of China). We used a network model to analyze the network structure of perceived social support, mindfulness, self-integrity, self-compassion, professional self-concept, savoring, intentional self-regulation, non-relational self-expansion, relational self-expansion, attachment insecurity, and psychological well-being. A highly interconnected network of psychological well-being featured predictors and traits were formed. Node 8 (self-kindness), node 9 (self-judgment), and node 23 (non-relational self-expansion) were the predictors with the highest centrality in the network. Perceived social support and professional self-concept were most central in linking predictors to psychological well-being traits. Attachment insecurity was a non-supportive factor for predicting psychological well-being among female nursing students.Interventions based on these supportive/non-supportive predictors, which operate on different psychological levels, hold promise to achieve positive effects on psychological well-being among nursing students.
Pharmacopoeial Analysis of Inulin-Containing Medicinal Plant Raw Materials and Drugs

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background: Today, there are some unresolved issues and discussions concerning inulin quantitative determination in medicinal plant raw materials (MPRM). MPRM containing polyfructans or fructosans (inulin and others) are rather complex multicomponent matrixes with many interacting compounds. The article discusses the prospects for further standardization of inulin-containing pharmacopoeial MPRM that include, in addition to polysaccharides (inulin), other biologically active compounds with pharmacological activity. Materials and Methods: Different types of search tools such as Google scholar, Google, scientific literature, normative documentation of Russian Federation (State Pharmacopoeia of Russian Federation IV edition and others) electronic databases such as e-Library, Scopus, Web of Science, Pubmed had been searched and data obtained. Results: The pharmacopoeial spectrophotometric procedures of inulin determination in the Russian Federation are approved in a version that does not fully satisfy modern standardization criteria. Regulatory changes required in the near future. Conclusion: Undoubtedly, to determine inulin quantitatively, it is necessary to modify the existing spectrophotometric procedures and introduce an additional alternative, more specific HPLC-RID (or similar) ones.
Contextualization in the context of mainstream ‘rock’ music listeners

Field: Arts and Humanities (Social Sciences)

Journal of Adventist Mission Studieswere often an anticlimax.We need more walk-through case studies of recent contextualization.Contextualization is not an arcane and erudite skill.You just have to do your best to fit the context of your intended listeners.Last year, after returning from thirty years in Asia to take up local church ministry in rural Australia, one of the big events of my new parish rolled up and over me.My new parish, Toowoomba, hosts Australia's largest Christian music festival, the Australian Gospel Music Festival (AGMF).The AGMF offers a celebration of faith, friendship, and music for nearly 40,000 people, with music ranging from Scar to Psalms, Jazz to Metal.Last year's acts included international names such as Sonicflood, Delirious, Brooke Fraser, and Lads.It included Contemporary Christian Music (CCM) legends
IMPROVING PERFORMANCE CAPABLE KNOWLEDGE IN YOUTH BASKETBALL BY APPLYING WITH TARGETED SHOOTING PROGRAM

Field: Psychology (Social Sciences)

Today’s basketball player profile can be divided to four resources: physical, mental, spiritual and emotional (Woods, Jordan, 2010). Our research supervised the special basketball demands and the implementations to a training program that could help us to get a correct picture what, when, whom, how, where and why to teach (Winter, 1997). We researched the game performances as the ingredients of competitiveness based on a research of (Baker and Shea, 2013) and the theory of Four Factors by Dean Oliver (2004) as our starting points. Purpose of study. Evaluate of every scientific hypothesis. Observing a special shooting program that is used yearly and simultaneously for a men university basketball team. The main goal of our research is to analyses the common effects of these programs for the game performances of the players. Understanding the basketball player profiles of the participants regarding to their game performances. We’d like to find the details of the improvement of the game performances with a new method that will separate the team and individual parts of the training process. Our hope is that our findings will be useful for planning the basketball practices. We look for the answers which practice topics, drills, tests types and methods are the most effective to increase the special game performance in this model. Methods. We looked for answers on why and how questions with our descriptive research methods. We guaranteed the validity of our work to choose our model systemically. We followed a longitudinal and panel investigation to guarantee the proper tests data. The data were analyzed statistically with ANOVA regression, T probe. We have also used some expert explanation from the gathered data. Hudl video analyzer program. Results. 1. The game statistics of the players who took part on the individual shooting and conditional program do not affect the trend lines of the game performances. 2. The eFG% and FTF do not affect the trend lines of the game performances. No significant different because of the field goal and free throw attempts (434/193 - 88/49 and 99/78 - 39/26). 3. The players who were involved of the morning sessions had more attempts on the games and so higher point/game averages. (49.3 PPG - 14.1 PPG). They executed their shots with a colorful technical repertoire. Their game performance and statistics were more effective. Conclusions. The longitudinal investigation was reasonable because the goals and the programs must be changed within the yearly practice plan. The teaching methods depends on the changes of the offensive strategy of the team. The more information we have about the physical and mental resources, the more effective practice plan can be designed. A competitive shooting program can be properly designed that will consider the significant variants due to our findings. There is a significant connection between the performance of the practice program and the game performances.
The basic elliptic equations in an equilateral triangle

Field: Mathematics (Physical Sciences)

In his deep and prolific investigations of heat diffusion, Lamé was led to the investigation of the eigenvalues and eigenfunctions of the Laplace operator in an equilateral triangle. In particular, he derived explicit results for the Dirichlet and Neumann cases using an ingenious change of variables. The relevant eigenfunctions are a complicated infinite series in terms of his variables. Here we first show that boundary-value problems with simple boundary conditions, such as the Dirichlet and the Neumann problems, can be solved in an elementary manner. In particular, the unknown Neumann and Dirichlet boundary values can be expressed in terms of a Fourier series for the Dirichlet and the Neumann problems, respectively. Our analysis is based on the so-called global relation, which is an algebraic equation coupling the Dirichlet and the Neumann spectral values on the perimeter of the triangle. As Lamé correctly pointed out, infinite series are inadequate for expressing the solution of more complicated problems such as mixed boundary-value problems. In this paper we show, further utilizing the global relation, that such problems can be solved in terms of generalized Fourier integrals .
Duty in the time of epidemics: what China and Zimbabwe teach us

Field: Social Sciences (Social Sciences)

In November 2002, a man with 'atypical pneumonia' treated in Foshan hospital, Guangdong Province, in the People's Republic of China, was the first known case of Severe Acute Respiratory Syndrome (SARS). However, it was not until April 2003 that the Chinese government admitted to the full scale of 'atypical pneumonia' cases infected with SARS, two months after the disease had rapidly spread across the world with initial infections in Hong Kong and Vietnam sourced to Guangdong. In 2008, Zimbabwe experienced one of the biggest outbreaks of cholera ever recorded. By February 2009, the disease had spread across all of Zimbabwe's 10 provinces and to neighbouring countries-Botswana, South Africa, Zambia and Mozambique-causing thousands of infections amongst their populations. This article seeks to examine what duties the Chinese and Zimbabwe states had to protect their citizens and the international community from these outbreaks. The article refers to the findings of the International Law Commission's study into the role of states and international organisations in protecting persons in the event of a disaster to consider whether there is an international duty to protect persons from epidemics. The article concludes that both cases reveal a growing concept of protection that entails an international duty to assist individuals when an affected state proves unwilling or unable to assist its own population in the event of a disease outbreak.
RETRACTED: Chung et al. Long-Lasting Exendin-4-Loaded PLGA Nanoparticles Ameliorate Cerebral Ischemia/Reperfusion Damage in Diabetic Rats. J. Pers. Med. 2022, 12, 390

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The Journal retracts the article “Long-Lasting Exendin-4-Loaded PLGA Nanoparticles Ameliorate Cerebral Ischemia/Reperfusion Damage in Diabetic Rats” [...]
Natural Triterpenoid‐ and Oligo(Ethylene Glycol)‐Pendant‐Containing Block and Random Copolymers: Aggregation and pH‐Controlled Release

Field: Chemical Engineering (Physical Sciences)

Abstract In this research, a series of random and block amphiphilic copolymers of norbornene derivatives containing biocompatible natural triterpenoid and oligo(ethylene glycol) pendants were synthesized by ring‐opening metathesis polymerization. These copolymers were heat and pH responsive, and could self‐assemble into core–shell spherical micelles in aqueous solution. Their hydrodynamic diameters corresponded to pH values and monomer sequences. By evaluating the loading and release capacity of hydrophobic molecules, it was found that 1) the higher the content of the hydrophobic triterpenoid, the higher the loading capacity; 2) the release speed could be trigged by the pH because of the deprotonation of the carboxyl groups on the triterpenoid. Additionally, the copolymers exhibited low cytotoxicity toward L929 cells, which makes them potential nanocarrier candidates for controlled drug delivery.