jimnoneill/paper-to-field-training huggingface dataset:
A phase 2 study of alrizomadlin (APG-115) in combination with pembrolizumab in patients with unresectable or metastatic cutaneous melanoma that has failed immuno-oncologic (IO) drugs.

Field: Medicine (Health Sciences)

9559 Background: Alrizomadlin is a novel, orally active small-molecule MDM2 inhibitor that activates p53-mediated apoptosis in tumor cells, also functions as a host immunomodulator, and may restore antitumor activity in patients with cancer that has progressed on PD-1/PD-L1 inhibitors. Alrizomadlin is currently being investigated for treatment of patients with unresectable or metastatic cutaneous melanoma that progressed on prior immunotherapy. Methods: This multicenter clinical trial was conducted in the United States and Australia in patients with unresectable or metastatic cutaneous melanoma that had progressed on PD-1/PD-L1 immunotherapy. Eligible patients had an ECOG performance status of 0-2. Alrizomadlin 150 mg was administered orally every other day for 2 consecutive weeks, with 1 week off, and pembrolizumab 200 mg intravenously for 30 minutes on Day 1 of a 21-day cycle. Results: As of December 12, 2022, preliminary and interim results are reported for 31 patients with cutaneous melanoma, of whom 21 were male and 10 female, with a median (range) age of 65 (27-84) years. Treatment-related adverse events (TRAE) of any grade ( > 10%) for either alrizomadlin or pembrolizumab were reported in 30/31 (96.8%) patients. These AEs included nausea (71%), vomiting (38.7%), fatigue (35.5%), thrombocytopenia (32.3%), diarrhea (25.8%), neutropenia (19.4%), decreased appetite (16.1%), and decreased leukocyte count (12.9%). A total of 4/31 (12.9%) patients reported treatment-related serious AEs, including anemia, thrombocytopenia, deep vein thrombosis, joint effusion, pulmonary embolism, and vomiting. In 26 efficacy-evaluable patients, the confirmed overall response rate (ORR; partial response [PR] + complete response [CR]) was 23.1%, including 2 patients reporting CRs and 4 reporting PRs based on RECIST v.1.1. The initial analysis indicated that the ORR observed in patients whose disease had failed IO treatment was primarily due to alrizomadlin combined with pembrolizumab, not the delayed effect of prior immunotherapy. Conclusions: Alrizomadlin combined with pembrolizumab is well tolerated and demonstrates clinical efficacy in these patients with highly refractory unresectable or metastatic cutaneous melanoma that had progressed on PD-1/PD-L1 immunotherapy. Internal study identifier: APG-115-US002. Clinical trial information: NCT03611868 .
From Likes to Earnings: The Lived Experiences of Real Estate Professionals Using Social Media Marketing

Field: Business, Management and Accounting (Social Sciences)

This study explores the lived experiences of licensed real estate professionals and agents who use social media in marketing properties that lead from “likes to earnings” in Cebu City, Philippines. Creating a prospective client and boosting sales listings for their promotional advertisements on social media is essential. The research provides the theory on the role of social media marketing and sales in the real estate market. It is based on the Social Media Engagement Theory (SMET) described by Kaplan and Heinlein, which emphasizes the role of user interaction or engagement on social media platforms. Moreover, the paper investigates social media user engagement and examines the interplay between social relations and digital tools. Although SMET has limitations, it is crucial as it guides social media marketing strategies and helps understand user behavior. The research is a qualitative method and uses interpretive hermeneutic research design principles to interpret the data. Furthermore, the study’s findings show the implications of social media marketing, including the utilization of digital tools strategically, ethical conduct, and lifelong learning to maintain leads and targeted clients’ buying behavior. Further, the SOSIS Marketing Model for real estate practitioners as an output of this study would greatly help improve the overall performance of both real estate practitioners and agents. In essence, this study helps recognize social media’s engagement in the real estate industry with feasible implications for professionals in the sector to develop efficient marketing strategies.
The association of smoking and prevalent adenomatous polyp characteristics

Field: Medicine (Health Sciences)

We assessed the relationship of cigarette smoking to the location, size, and histology of prevalent adenomatous colorectal polyps detected among 1429 participants, all adenoma patients, in a randomized trial testing the effects of a high (13.5 g/day) versus low (2 g/day) wheat bran fiber intervention on adenoma recurrence. Participants had a complete qualifying colonoscopy with at least one histologically confirmed adenomatous polyp 3 mm or larger. Location, size and histology of the baseline adenoma(s) were recorded. Cigarette smoking was evaluated at baseline through a self-administered questionnaire. Among the study participants, 66% had a history of ever smoking and 14% were current smokers. Compared to never smokers, those in the upper tertile of pack-years of smoking had a lower, non-significant risk of having one or more of their adenomas in the proximal colon (OR = 0.79; 95% CI = 0.53-1.16) and a lower risk of having one or more of their adenomas of villous histology (OR = 0.63; 95% CI = 0.43-0.94). Individuals in the upper tertile of pack-years of smoking were more likely to have a large (>1 cm) adenoma (OR = 1.27; 95% CI = 0.91-1.76) but no dose-response was observed. These results suggest that among adenoma patients, those who are exposed to cigarette smoking are more likely to have distal adenomas versus adenomas found only in the proximal colon. Exposure to cigarette smoke is a predictor of non-villous as opposed to villous adenomas and is not associated with adenoma size. These data describe correlations of adenoma characteristics among adenoma patients; they do not refer to the probability of adenoma presence.
Conceptual approach to the phenomenon of tourism to-day

Field: Social Sciences (Social Sciences)

This paper revises the fundamental concepts referring to the phenomenon of tourism and its social implications in the contemporary times. It has been structured into six sections, after the pertinent introduction. The second part gives a summery of the origin of tourism. The third part concerns a range of concepts and typologies that are been elaborated in order to clearly understand the phenomenon, the elements that compose its structure. The fourth part analyses the consequences of its dynamic, before to speak about the ideology and its commercial development. Finally, it places the tourism between ecology and development. PALABRAS CLAVE | KEYWORDS antropologia del turismo | actividad turistica | publicidad | anthropology of tourism | tourist activity | advertising
Assessment of line differentiation in the Thoroughbred horse breed using DNA microsatellite loci

Field: Agricultural and Biological Sciences (Life Sciences)

The Thoroughbred (TB) horse is the best racehorse breed used in the racing industry. This breed has had a closed studbook for about 300 years. In Russia TB horses have been bred since the second half of the XVIII century. The modern Russian Stud Book register of TB horses is partially presented by stallions and broodmares imported from different countries. The genealogical structure of the breed is represented by 17 lines, among which the Northern Dancer line dominates (30.9 %). The study of features of different lines of TB was carried out on 17 loci of DNA microsatellites ( VHL20 , HTG4 , AHT4 , HMS7 , HTG6 , AHT5 , HMS6 , ASB23 , ASB2 , HTG10 , HTG7 , HMS3 , HMS2 , ASB17 , LEX3 , HMS1 and CA425 ) to assess genetic differentiation of the genealogical structure. The results of the DNA typing of 8091 Thoroughbred horses across microsatellite loci show that the gene pool of the domestic population is represented by 100 alleles typical of the breed. A comparative analysis of the genotypes of horses representing different lines indicates that they differ in the number of alleles (85–99), allele frequencies, the level of polymorphism Ae (2.93–3.48) and the degree of the observed heterozygosity Ho (0.653–0.739). The genetic distances between the lines varied in a wide range from 0.014 (Nasrullah – Northern Dancer) to 0.125 (Massine – Teddy). The correspondence to HWE was maintained in most lines, which is confirmed by the negative values of Fis . Cluster analysis demonstrated the correspondence of the obtained dendrogram of Nei’s genetic distances to its genealogical scheme of lines. Genetic differentiation of lines by index Fst varied in a range 0.005–0.073 at the mean value Fst = 0.024. The data indicate genetic differentiation of lines of TB at the STR markers and confirm the effectiveness of the system of linear breeding for the maintenance of interbreed biodiversity.
Phenol-mediated suppression of soil-borne root-infecting fungi in mungbean

Field: Agricultural and Biological Sciences (Life Sciences)

Under field conditions, there is a variety of phenolic acids as well as other toxic and non-toxic organic
compounds that interact with plant seeds and roots; but in laboratory bioassays, with few exceptions, only single
phenolic acids are usually tested. In this study, the effect of various concentrations of two phenolics (caffeic acid
and p-hydroxybenzoic acid) on the wilt-inducing fungus Fusarium solani and the damping-off fungus Rhizoctonia
solani was tested in pot experiments. The effect of these phenolics on the biocontrol efficacy of Pseudomonas
aeruginosa, a plant growth-promoting rhizobacterium, was also evaluated. Caffeic acid and p-hydroxybenzoic acid
significantly suppressed F. solani and R. solani infection in mungbean. However, high concentrations of the phenolic
acids interfered with plant growth. P. aeruginosa in the rhizosphere declined in the presence of caffeic acid
and p-hydroxybenzoic acid.
The Quantitative Assessment of Antimicrobial Agents: The Case of Sub-Inhibitory Concentrations of Eucalyptus globulus Essential Oil Against Staphylococcus aureus

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et a ̀ la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Pengembangan Modul Bergambar untuk Meningkatkan Pemahaman Materi Jenazah di Kelas VI

Field: Arts and Humanities (Social Sciences)

Learning is a complex process that occurs in everyone throughout his life. The learning process occurs because of the interaction between a person and his environment. One alternative that can be done by teachers so that students can play an active and independent role in developing their knowledge is to use picture modules. Picture modules help teachers and students in implementing the teaching and learning process in schools because the picture media students will be more interested in learning. The purpose of this study was to determine the students' understanding of SDN Pulogedang Jombang in understanding corpse material using a picture module. This type of research is development research (R&D). The product developed is in the form of a picture module of corpse material. The instruments used in this study were an assessment questionnaire by two validators, a student questionnaire assessment sheet and pre-test and post-test questions on learning outcomes. Based on the results of the validation sheet, the illustrated module is classified as suitable for use in learning Islamic Religious Education on corpse material. This can be seen from the results of the validation of the first and second material experts of 3.2. Students' understanding of the use of the illustrated module can be seen from the results of the pre-test and post-test with an average score of 68.45 increasing to 87.06.
SPDEs with non-Lipschitz coefficients and nonhomogeous boundary conditions

Field: Mathematics (Physical Sciences)

In this paper we establish the strong existence, pathwise uniqueness and a comparison theorem to a stochastic partial differential equation driven by Gaussian colored noise with non-Lipschitz drift, Hölder continuous diffusion coefficients and the spatial domain in finite interval, $[0,1]$, and with Dirichlet, Neumann or mixed nonhomogeneous random conditions imposed on the endpoints. The Hölder continuity of the solution both in time and in space variables is also studied.
Genome-Wide Analysis of bHLH Gene Family in Loropetalum chinense var. Rubrum: Identification, Classification, Evolution, and Expression Pattern Diversity on Cultivations

Field: Agricultural and Biological Sciences (Life Sciences)

The basic helix-loop-helix (bHLH) transcription factor family is the second-largest transcription factor in plants. Members of this family are involved in the process of growth and development, secondary metabolic biosynthesis, signal transduction, and plant resistance. Loropetalum chinense var. rubrum is a critical woody plant with higher ornamental and economic values, which used as ornamental architecture and traditional Chinese herbal medicine plant. However, the bHLH transcription factor in the L. chinense var. rubrum (Loropetalum chinense var. Rubrum) have yet to be systematically demonstrated, and their role in anthocyanin biosynthesis remains secret. Here, we identified 165 potential LcbHLHs genes by two methods, and they were unequally distributed on chromosomes 1 to 12 of the L. chinense genome. Based on a phylogenetic comparison with proteins from Arabidopsis, these bHLH proteins were categorized into 21 subfamilies. Most LcbHLHs in a given subfamily had similar gene structures and conserved motifs. The gene ontology annotation and cis-elements predicted that the LcbHLHs had many molecular functions and were involved in plant growth processes, including flavonoid and anthocyanin biosynthetic processes, etc. Transcriptomic analysis revealed different expression patterns among different tissues and cultivars in L. chinense. Many LcbHLHs were expressed in leaves, and only a few genes were highly expressed in flowers. Six LcbHLH genes differentially expressed between species and periods in color variation, which may play a key role in anthocyanin synthesis. These further functional predictions of LcbHLHs were established by quantitative real-time PCR analysis and protein-protein interaction network. This study identified the six potential bHLH genes related to anthocyanin in L. chinense and created a solid framework for future research on the function and evolution of bHLHs.
Zur Zikadenfauna des Großen Arber im Bayerischen Wald: (Hemiptera: Auchenorrhyncha)

Field: Agricultural and Biological Sciences (Life Sciences)

Contribution to the Auchenorrhyncha fauna of the Großer Arber, Bavarian Forest (Hemiptera: Auchenorrhyncha). – The fauna of plant- and leafhoppers of the Bavarian Forest is not well studied. On 30.06.2007 an excursion to the Großer Arber, which is the highest mountain of the range, was organized. In total, 27 species were collected. Together with results from an ongoing project on the altitudinal distribution of plant- and leafhoppers of the Bavarian Forest 50 species are now known to occur at higher elevations (above 1000 m) at the Großer Arber. Additionally, on 01.07.2007 a wet grassland site in the Zellertal near Arnbruck (520 m) was visited and 55 species have been recorded there.
DIAMOND SYNTHESIS BY DC PLASMA JET CVD

Field: Materials Science (Physical Sciences)

Abstract This paper reviews our research on diamond synthesis by etc plasma jet CVD. The unique feature of this method is supplying high radical density plasma to a substrate by quenching a thermal plasma. The maximum growth rate is 200 μm/h. The crystallinity measures well in terms of x-ray diffraction and Raman spectroscopy. The morphology of diamond film is affected strongly by methane concentration and the spacing between the torch nozzle and substrate. Plasma analysis by optical emission spectroscopy indicates that the plasma jet is not in equilibrium and contains many activated radicals. This paper also describes our application of a thick diamond film to the heat sink of a laser diode.
Characterizing the Dietary Landscape of Children, 12 to 35 Months Old

Field: Health Professions (Health Sciences)

Dietary intakes in childhood are one of several factors that influence food and beverage choices later in life. Nationally representative dietary data of US children aged 1 and 2 years (toddlers) (n = 469) participating in the “What We Eat in America” component of the 2011-2012 National Health and Nutrition Examination Survey were analyzed to assess food, beverage, and nutrient intakes. Dietary intakes were collected using 24-hour dietary recall interview conducted by proxy that was usually the mother. Mean and distribution of usual nutrient intakes, percentage meeting dietary reference intakes, meal and snack patterns, and intakes of foods and beverages were estimated. The energy intake of toddlers was 1335 kcal/d. Usual nutrient intakes of vitamins D and E were less than the recommended intake levels by 86% and 62% of toddlers, respectively. Almost all toddlers (96%) had usual intakes less than the recommendations for dietary fiber and potassium, and 71% exceeded the upper level for sodium. Mean daily intake of added sugars was 10% of daily energy intake, with approximately 40% of toddlers exceeding that level. Mean daily snack occasion of toddlers was 3.1, which contributed one-third of their daily energy intake. Beverages contributed one-fourth of their daily energy intake. On the basis of 1 day of dietary recall, milk, water, and 100% fruit juice were the top beverages consumed by toddlers. Soft drinks were consumed by 14% of toddlers. Grain products, protein foods, and mixed dishes were each consumed by at least three-fourths of the toddlers. A greater proportion of toddlers consumed fruit (71%) compared with vegetables (57%). Nearly 1 in 3 toddlers consumed candy, and 2 in 5 consumed cakes/cookies/pastries. More than one-third consumed savory snacks, including chips, popcorn, and pretzels, and an equal proportion consumed crackers. Although the dietary intakes of toddlers met the recommendations for many nutrients, the consumption of food and beverage choices that were not nutrient dense may merit concern. Less healthy choices, introduced at early ages, may shape dietary habits across the life-span.
Fan beam image reconstruction using generalized natural pixel bases [SPECT]

Field: Computer Science (Physical Sciences)

The purpose of this study is to represent the natural pixel basis for fan beam geometry. The image equation for generalized natural pixel basis can be described as Mq=p, where p is the projection measurement, q is the unknown estimation, and matrix M is the backprojection-projection operation. Without considering photon scatter, geometric response, and attenuation, the natural pixel representation of the projection operator for fan beam geometry is a unit strip of which central line is along the line from the center of the detector bin to the focal point. Since the backprojection operator can be different from the adjoint projection operator, one fan beam, two parallel beam backprojection operators were used to define the behavior of the backprojection functional. The singular value decomposition (SVD) reconstruction method is used to solve q in this inverse problem, and the final image is obtained by backprojecting this q into a discrete array of points. We observed that different backprojection geometries can reconstruct almost an identical image. Moreover, the use of the natural pixel basis for fan beam geometry has higher resolution than the filtered backprojection algorithm.
Can sunspot activity and ultraviolet–B radiation explain cyclic outbreaks of forest moth pest species?

Field: Environmental Science (Physical Sciences)

Cyclic outbreaks of forest moth pest species have long remained a puzzle for foresters and ecologists. This paper presents time-series exhibiting a strong negative relationship between sunspot numbers and population indices of autumnal and winter moths, both in a mountain birch forest in central Norway and in a mixed lowland forest in southern Norway. In the latter area, also the population level of a moth species feeding entirely on lichens was negatively related to sunspot numbers. Low sunspot activity leads to a thinner ozone layer and thus higher surface ultraviolet (UV)-B radiation. As winter moth larvae prefer leaves subjected to enhanced UV-B radiation, we suggest that the causal relationship between sunspots and moths is that the metabolic costs of producing UV-B-protective pigments during periods of low sunspot activity reduce trees' and lichens' resistance to herbivores, and thus increase the survival of moth larvae. Higher peak densities of moth cycles in mountain forests could be explained by the general higher UV-B radiation at higher altitudes.
Epigram on St. Luke

Field: Arts and Humanities (Social Sciences)

Epigram on St. Luke Get access J. A. Owles J. A. Owles Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s11-V, Issue 107, 13 January 1912, Page 28, https://doi.org/10.1093/nq/s11-V.107.28a Published: 13 January 1912
Proximity, Resemblance, Sidebars and Clusters: Ibn al-Nadīm’s Organizational Principles in Fihrist 3.3

Field: Arts and Humanities (Social Sciences)

The Kit?b al-Fihrist of Ibn al-Nad?m (d. 380/990), one of the most important bio-bibliographical works in Arabic, is an invaluable source for the study of the first four centuries of Arabic writerly culture and of medieval Islamicate history. Ibn al-Nad?m divides his work into 10 parts (and 30 chapters), organised according to different fields of knowledge and scholarship. He also subdivides the notices, entries and titles very deliberately, typically chronologically. Here, I describe another organisational phenomenon discernible in the third chapter of the third part of the Fihrist, namely organization based on notions I term ?proximity? and ?resemblance?, which yield ?sidebars? and ?clusters.? This organisation yields valuable information about the writerly culture of the 3rd/8th, 4th/9th and 5th/10th centuries.