jimnoneill/paper-to-field-training huggingface dataset:
Decline in Glucokinase Activity in the Arcuate Nucleus of Streptozotocin-Induced Diabetic Rats

Field: Neuroscience (Life Sciences)

Glucokinase (GK) is known to be the critical glucose sensor of pancreatic B-cells. However, the localization and functional role of GK in the brain remains to be elucidated. In this study, we measured both the activity and mRNA level of GK in the hypothalamic nuclei and the cortex of rats injected intraperitoneally with streptozotocin or vehicle. GK activity was measured by a fluorometric assay; and the GK mRNA level, by use of the real-time reverse transcription polymerase chain reaction. GK activity in vehicle-treated rats was high in the arcuate nucleus, moderate or low in the ventromedial nucleus, lateral hypothalamic area, and paraventricular nucleus, and very low in the cortex. The order of GK mRNA level was almost the same as that of GK activity. GK activity and GK mRNA level only in the arcuate nucleus of streptozotocin-treated rats at 7 d, but not at 2 d, after treatment were lower than those of vehicle-treated rats. The results suggest that prolonged hyperglycemia induced by diabetes decreased the activity of GK in the arcuate nucleus.
Changes associated with the COVID‐19 pandemic on postpartum screening results in Ontario, Canada: The healthy babies healthy children screening tool

Field: Health Professions (Health Sciences)

Abstract Background Research on the impact of the COVID‐19 pandemic on mothers/childbearing parents has mainly been cross‐sectional and focused on psychological symptoms. This study examined the impact on function using ongoing, systematic screening of a representative Ontario sample. Methods An interrupted time series analysis of repeated cross‐sectional data from a province‐wide screening program using the Healthy Babies Healthy Children (HBHC) tool assessed changes associated with the pandemic at the time of postpartum discharge from hospital. Postal codes were used to link to neighborhood‐level data. The ability to parent or care for the baby/child and other psychosocial and behavioral outcomes were assessed. Results The co‐primary outcomes of inability to parent or care for the baby/child were infrequently observed in the pre‐pandemic (March 9, 2019–March 15, 2020) and initial pandemic periods (March 16, 2020–March 23, 2021) (parent 209/63,006 (0.33%)–177/56,117 (0.32%), care 537/62,955 (0.85%)–324/56,086 (0.58%)). Changes after pandemic onset were not observed for either outcome although a significant ( p = 0.02) increase in slope was observed for inability to parent (with questionable clinical significance). For secondary outcomes, worsening was only seen for reported complications during labor/delivery. Significant improvements were observed in the likelihood of being unable to identify a support person to assist with care, need of newcomer support, and concerns about money over time. Conclusions There were no substantive changes in concerns about ability to parent or care for children. Adverse impacts of the pandemic may have been mitigated by accommodations for remote work and social safety net policies.
[Enhancing effect of matrine on the tumor-inhibition by TIM2 gene-modified hepatocarcinoma H22 cells in mice].

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The tumorigenesity of H22 cells has been markedly impaired after modification by TIM2 gene. Matrine can enhance its inhibitory effect on tumors of H22-TIM2 cells in vivo. These data indicate importance to further study on the biological role of TIM2 gene in tumor immunity and explore the molecular mechanism of matrine in suppressing of tumor growth.
Cross-border wild polio virus transmission in CORE Group Polio Project areas in Ethiopia.

Field: Medicine (Health Sciences)

Cross-border transmission of polio can occur from several frontiers. Suggestions to control cross-border polio transmission included establishing and/or strengthening cross-border collaboration with responsible counterparts in neighboring countries by using existing cross-border forums and structures to create community awareness, share information and resources, design and implement strategies for identification of children who are eligible for vaccination or suspected AFP cases. In addition districts should coordinate supplemental immunization activities to coincide with when adjacent districts in neighboring countries are carrying out similar actions.
Erratum: PolarizedJ/ψproduction in deep inelastic scattering at DESY HERA [Phys. Rev. D 63, 034017 (2001)]

Field: Physics and Astronomy (Physical Sciences)

We perform a calculation on the polarization of J/ψ production in deep inelastic scattering in the HERA energy range.For the inclusive production distributions, we find that the color-singlet contributions are consistent with the experimental data in the major region of z (z > 0.4).Only in low z regions, there are some hints of the need of the color-octet contributions to describe the experimental data.For the polarization of J/ψ in DIS processes, we find the parameter α changes with Q 2 .Especially, at higher Q 2 , difference on α between color-singlet and color-octet contributions become more distinctive.In the two regions of lower and larger z, the polarization parameter α have different features.These properties can provide important information on the polarization mechanism for J/ψ production.
Perceived quality, customer satisfaction, and customer loyalty: the case of lexus in Taiwan

Field: Business, Management and Accounting (Social Sciences)

The purpose of this study is to examine overall customer satisfaction associated with Toyota's Lexus automobiles in Taiwan by applying Fornell et al.'s (1996) customer satisfaction index (CSI) model. By analysing a set of 320 Taiwanese Lexus owners of more than 7 months, the study uses the structural equation model with LISREL software to show that the perceived quality has a direct effect on overall customer satisfaction, and has an indirect effect on customer complaint-levels and customer loyalty. That is, customer expectations have a direct impact on customer perceived quality; therefore, such expectations have an indirect effect on overall levels of customer satisfaction. Not surprisingly, overall customer satisfaction negatively influences customer complaints and positively influences customer loyalty. Importantly, the study also finds that customer complaints do not have negative impact on customer loyalty. Additionally, the study demonstrates that the CSI model should be modified in the case of Lexus' Taiwanese customers: because the notion of 'perceived value' is not present in the existing model, further exploration is required. Finally, the study finds that firms should do their utmost to improve perceived quality, as doing so seems to represent the most effective way of increasing levels of customer satisfaction.
Lab-on-Chip assay of tumour markers and Human Papilloma Virus for cervical cancer detection at point-of-care

Field: Medicine (Health Sciences)

Abstract Cervical cancer affects over half a million people worldwide each year, the majority of whom are in resource-limited settingswhere cytology screening is not available. As persistent human papilloma virus (HPV) infections are a key causative factor,detection of HPV strains now complements cytology where screening services exist. This work demonstrates the efficacy of ahandheld Lab-on-Chip (LoC) device in detecting cervical cancer from biopsy samples. The device is based on Ion-SensitiveField-Effect Transistor (ISFET) sensors used in combination with loop-mediated isothermal amplification (LAMP) assays, toamplify HPV DNA and human telomerase reverse transcriptase (hTERT) mRNA. These markers were selected because of theirhigh levels of expression in cervical cancer cells, but low to nil expression in normal cervical tissue. The achieved analyticalsensitivity for the molecular targets resolved down to a single copy per reaction for the mRNA markers, achieving a limit ofdetection of 102for hTERT. In the tissue samples, HPV-16 DNA was present in 4/5 malignant and 2/5 benign tissues, withHPV-18 DNA being present in 1/5 malignant and 1/5 benign tissues. hTERT mRNA was detected in all malignant and nobenign tissues, with the demonstrated pilot data to indicate the potential for using the LoC in cervical cancer screening inresource-limited settings on a large scale
The effects of soil characteristics and physiographic factors on the establishment and distribution of plant species in mountain forests (Case study: Asalouyeh, South of Iran)

Field: Agricultural and Biological Sciences (Life Sciences)

The objective of this study was to assess the effects of soil characteristics and physiographic factors (slope, aspect and elevation) on vegetation distribution. We ultimately ascertained the most important characteristics on the establishment, regeneration and distribution of species in Asalouyeh mountain forests south of Iran. Vegetation sampling was performed using a randomized-systematic method and plot was determined by the minimal area method. Data relevant to the presence and abundance of plant species was also analyzed. Plant ecological groups were formed from vegetation data (TWINSPAN) and ordination analysis (DCA). Geographic information system (GIS) was employed for mapping plant ecological groups and for our digital elevation model (DEM). Ordination analysis was performed using DCA to determine the floristic composition of plant ecological groups and samples. To investigate the relationship between vegetation and soil characteristics, soil samples were selected from both organic horizons (0 to 7 cm) and mineral layers (7 to 25 cm). Soil characteristics such as texture, lime, and moisture, as well as pH, EC, N, P, C and KOH were included for analysis by the PCA method. The results showed that the vegetation distribution pattern was primarily related to soil characteristics and elevation. Additionally, the results revealed that the regeneration, establishment, growth, and sustainability of each plant species are dependent on the unique environmental conditions of soil characteristics and physiological factors.

Key words: Forest, soil, establishment, ordination, plant group.
Transurethral Sphincterotomy Provides Significant Relief in Autonomic Dysreflexia in Spinal Cord Injured Male Patients: Long-Term Followup Results

Field: Medicine (Health Sciences)

Blood pressure monitoring during cystometrogram provides an objective assessment of the presence of autonomic dysreflexia due to neurogenic bladder dysfunction, enabling better therapeutic management to control autonomic dysreflexia. Persistence of significant autonomic dysreflexia needs urodynamic evaluation if other factors for autonomic dysreflexia have been excluded.
Methadone Anonymous and Mutual Support for Medication-Assisted Recovery

Field: Health Professions (Health Sciences)

Patients in medication-assisted treatment for opioid addiction have been historically excluded or marginalized within mainstream recovery mutual-aid societies. The resulting isolation has sparked the rise of indigenous support structures organized by and for people in medication-assisted recovery. This article reviews the obstacles methadone maintenance patients experience in seeking to participate in mainstream 12-step groups and describes how Methadone Anonymous and other alternatives are providing recovery support for current and former methadone maintenance patients.
The implications of revised WHO classification (2008) of chronic myeloid neoplasms.

Field: Medicine (Health Sciences)

Myeloid disorders constitute a subgroup of hematological malignancies of myeloid lineage. In the revised 2008 WHO classification system, the nomenclature for myeloproliferative entities has been changed from "chronic myeloproliferative diseases" to "myeloproliferative neoplasms", the definition criteria has changed, and and the MDS/MPN has emerged as a well defined entity the subgroup formerly known as "myelodysplastic/myeloproliferative diseases" has changed to "myelodysplastic/myeloproliferative neoplasms". The World Health Organization classification of myeloid neoplasms relies on the association of clinical, morphologic, immunophenotypic and genetic diagnostic features. The current review highlights these changes and also provides diagnostic algorithms that are tailored to routine clinical practice.
SELL AND BUY TRANSFER OF MOTORCYCLE WITH ADVANTAGES OF A MUAMALAH FIQH PERSPECTIVE (Case Study In Ingin Jaya Districts Aceh Besar District)

Field: Arts and Humanities (Social Sciences)

Buying and selling over motorcycle financing with profits in the District of Ingin Jaya, namely by transacting motorbikes that are still in financing by obtaining profits and this has become a habit for the people of the Ingin Jaya community. for this reason, the sellers and buyers need to know how the practice of buying and selling over motorcycle financing with profits that are in accordance with the perspective of the sale al-ba’i and hiwalah. In this study the authors used a descriptive analysis research method based on data obtained from interviews with Yamaha Sales Executive, Second Motorbike business owner Umar Matang and buyers from the general public which included transaction procedures and understanding in the agreement to set prices until the transfer was made. The results show the agreement between the seller and the buyer is based on a sense of willingness and an element of help on the condition that the leasing company that provides financing know and approves the transfer is made. And the buyer of the transferred motorbike of the Financing negotiates the transfer price with the first owner and later the buyer of the second motorbike will continue the remaining deposit. From the perspective of the Hiwalah and al-ba'i and Al-Milk At-Tamm contracts, the transfer and sale and purchase transactions that occur are very much in accordance with the concept of Hiwalah, al-ba'i, and complete ownership requirements (Al-Milk At-Tamm) in fiqh muamalah, and also the profits obtained are considered legitimate in buying and selling because the profits are obtained from goods that have clear ownership and are known between the two so that neither party is injured. The transaction has also become a good habit for the people of the District of Ingin Jaya.
A precision architecture for high-speed amplifier applications

Field: Engineering (Physical Sciences)

A circuit configuration is suggested for the design of fixed-gain amplifiers that are intended for integrated circuit fabrication and that require both accuracy and high-speed. The approach, which does not employ negative feedback, is demonstrated in both BJT and HBT processes. Fixed-gain amplifiers are designed and tested to a specification of 0.1% gain accuracy and bandwidths in excess of 2 GHz.
Evidence for graft colonization with periodontal pathogens in lung transplant recipients

Field: Medicine (Health Sciences)

Summary Bronchiolitis obliterans syndrome (BOS) is a major cause of late graft dysfunction in lung transplant recipients. There is increasing evidence that beside alloimmunologic injury also non-alloimmunologic inflammatory conditions may raise the risk of acute and chronic rejection. The oral cavity represents a possible reservoir for pathogenic bacteria due to its close anatomical proximity. In this pilot study, the presence of pathogenic periodontal bacteria in the oral cavity as well as in the lungs of lung transplant recipients was investigated for the first time. Eight lung transplant recipients underwent broncho-alveolar lavage, transbronchial biopsies, and endobronchial biopsies. In addition to routinely performed examinations, pulmonary as well as plaque samples were assessed for Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythia (Tf), Porphyromonas gingivalis (Pg), and Treponema denticola (Td) with the aid of a hybridization technique. No or only one periodontal pathogen (solitarily Pg) was found in the gingival plaques of five of the eight patients (group A). In three patients, two or more periodontal pathogens were detetectable in the gingival samples (group B). Whereas group A also had not more than one periodontal pathogen in the lungs, group B had more than one species in the lungs. In group B, all patients suffered from BOS, whereas in group A only one patient was affected. This is the first evidence for the presence of periodontal pathogens in the lungs of lung transplant recipients. Further studies with larger cohorts are required to elucidate potential links between periodontal infection, pulmonary colonization, and rejection.
Correlates of Fetal Growth and Survival

Field: Medicine (Health Sciences)

ABSTRACT. Data on 36611 singleton deliveries in Indonesia were used to contrast patient characteristics, obstetric history and pregnancy outcome for two birth weightgroups among women experiencing the best and poorest stillbirth rates, namely 3000‐3499 g and <2500 g, respectively. The low birthweight groiup was characterized by younger age at first marriage, rural residence, lower educational attainment, less antenatal care and poorer pregnancy outcome and infant survival. Both groups showed progressive anemia prevalence with increasing parity with lower hemoglobin levels for the low birth weight group. Stillbirth rates were particularly high (60.6 per 1000 pregnancies) for the under 20 year olds in the lower birthweight group. The results suggest poorer maternal nutrition among women with lower educational achievement, higher energy expenditures among rural women, nutritional reserves depletion with increasing parity and competition between the teenager's nutritional needs for her own physical growth and fetal growth as factors in low birthweight and perinatal mortality.
The Effectiveness of Porpe (Predict, Organize, Rehearse, Practice, and Evaluate) Method to Teach Reading Viewed from Students’ Self-Esteem

Field: Arts and Humanities (Social Sciences)

This article reports a study on the implementation of PORPE method to teach reading at the tenth grade students in the academic year of 2012/2013. The objectives of the research are to find out whether: (1) PORPE method is more effective than Direct Instruction Method to teach reading for the tenth grade students; (2) Students who have high self-esteem have better reading skill than those who have low self-esteem; and (3) there is aninteraction between methods of teaching and students’ self-esteem to teach reading. This study was categorized as an experimental research. The population of the research was the tenth grade students in the academic year of 2012/2013. The sample of this research was taken by using cluster random sampling. The sample of this research was 60 students covering 30 students of experimental class taught using PORPE method and 30 students of control class taught using Direct Instruction Method. The data collection was done by giving self-esteem questionnaire and reading test (post-test) after eight meetings of treatment. The data analysis was done by applying descriptive and inferential statistics (ANOVA and Tukey HSD test) to test the research hypothesis. The findings of this research are: (1) PORPE Method is more effective than Direct Instruction Method to teach reading at the tenth grade students; (2) The students having high self-esteem have better reading skill than those having low self-esteem; and (3) there is an interaction between teaching methods and self-esteem in teaching reading. The effect of teaching methods on students’ reading skill depends on the students’ self-esteem level.
An unholy alliance: Swiss citizenship between local legal tradition, federal laissez-faire, and ethno-national rejection of foreigners 1848–1933

Field: Social Sciences (Social Sciences)

This article traces the development of the federal structure of Swiss citizenship between the founding of the federal state in 1848 and the entrenchment of a restrictive naturalisation and establishment policy in the interwar period. Considering the difficult integration of foreign residents through naturalisation in the past and present in Switzerland, the author examines the causes for the granting and refusal of Swiss citizenship. She shows that the development of and arrangements for access to Swiss citizenship cannot be reduced only to notions about the Swiss nation or national interests. They are the result of a permanent process of political negotiation and coordination between the federation, cantons and local authorities; owing to its importance in social assistance matters, local citizenship constituted an impediment to naturalisation until well into the twentieth century. In contrast, the federation and certain cantons like Zurich, Basle and Geneva had sought since the 1880s to reduce the strongly increasing number of foreign residents by liberalising naturalisation. The outbreak of the Second World War put an end to these endeavours. With the rise of a ‘new right’ since 1900, the setting up of the Central Office of the Foreign Police in 1917, and the institutionalisation of the authorities' ‘fight against foreign infiltration’, Swiss nationality law became ethnicised. Cultural ‘assimilation’ into the ‘particularity of Swiss society’ was now regarded as a precondition for becoming a Swiss citizen. The new federal rejection of foreigners thus joined with the traditionally restrictive policy of local authorities in an unholy alliance that began to breach only in the 1980s.
Study of bulk and elementary screw dislocation assisted reverse breakdown in low-voltage (&gt;250 V) 4H-SiC p/sup +/-n junction diodes. I. DC properties

Field: Materials Science (Physical Sciences)

Given the high-density (/spl sim/10/sup 4/ cm/sup -2/) of elementary screw dislocations (Burgers vector=1c with no hollow core) in commercial SiC wafers and epilayers, all large current (>1 A) SiC power devices will likely contain elementary screw dislocations for the foreseeable future. It is therefore important to ascertain the electrical impact of these defects, particularly in high-field vertical power device topologies where SiC is expected to enable large performance improvements in solid-state high-power systems. This paper compares the dc-measured reverse-breakdown characteristics of low-voltage (<250 V) small-area (<5/spl times/10/sup -4/ cm/sup 2/) 4H-SiC p/sup +/-n diodes with and without elementary screw dislocations. Diodes containing elementary screw dislocations exhibited higher pre-breakdown reverse leakage currents, softer reverse breakdown current-voltage (I-V) knees, and highly localized microplasmic breakdown current filaments compared to screw dislocation-free devices. The observed localized 4H-SiC breakdown parallels microplasmic breakdown observed in silicon and other semiconductors, in which space-charge effects limit current conduction through the local microplasma as reverse bias is increased.
Agamben’s Joyful Kafka : Finding Freedom Beyond Subordination

Field: Arts and Humanities (Social Sciences)

Both Giorgio Agamben and Franz Kafka are best known for their gloomy political worldview. A cautious study of Agamben's references on Kafka, however, reveals another dimension right at the intersection of their works: a complex and unorthodox theory of freedom. The inspiration emerges from Agamben's claims that 'it is a very poor reading of Kafka's works that sees in them only a summation of the anguish of a guilty man before the inscrutable power'. Virtually all of Kafka's stories leave us puzzled about what really happened. Was Josef K., who is butchered like a dog, defeated? And what about the meaningless but in his own way complete creature Odradek? Agamben's work sheds new light on these questions and arrives, through Kafka, at different strategies for freedom at the point where this freedom is most blatantly violated.