jimnoneill/paper-to-field-training huggingface dataset:
A pilot feasibility study of gastroparesisclinic. org: An online assessment and psychological treatment program for gastroparesis patients

Field: Health Professions (Health Sciences)

Objective: Gastroparesis is associated with significant psychological distress and impaired quality of life (QoL). This study explored the feasibility of an online psychological treatment program for individuals with gastroparesis. It was expected that individuals who completed the program would report reduced gastroparesis symptom severity, psychological distress, and maladaptive coping, in addition to improved illness perceptions, adaptive coping, and QoL at post-intervention assessment compared to baseline. Methods: Adults with gastroparesis were recruited for a six-week online treatment program targeting gastroparesis-related psychological distress. Participants completed a self-report questionnaire assessing gastroparesis symptom severity, illness perceptions, coping style psychological distress, and QoL at baseline and post-intervention. Participants also provided feedback on the program. Of 97 participants who completed the baseline assessment, six also completed the post-intervention assessment. Results: Participants who completed the program demonstrated trends of reduced symptom severity, negative illness perceptions and psychological distress, increased adaptive and maladaptive coping, and improved QoL. Feedback indicated a generally positive response to the program, which participants thought was an acceptable way \nof dealing with gastroparesis symptoms and would willingly recommend to a friend. Participants provided suggestions regarding module and program duration, and quantity of homework. Completers and non-completers did not differ significantly on symptom severity, illness perceptions, coping styles, psychological distress, QoL, or demographic variables except for a geographical influence. Conclusions: These preliminary results indicate that a structured online program is a feasible method of providing targeted psychological support for the gastroparesis cohort. The program was associated with a trend of improvement in symptom severity, illness perceptions, \npsychological distress, and QOL. Future research should address feedback from participants, which may also improve attrition, and conduct a randomized controlled trial as the next step in validation of the gastroparesisclinic.org program. Policy of full disclosure: None.
The Effects of Aromatherapy on the Depression and Stress in Patients with Stroke

Field: Health Professions (Health Sciences)

국문요약 ⅰ

차례 ⅲ

그림차례 ⅴ

표차례 ⅵ

Ⅰ. 서론 1

A. 연구의 필요성 1

B. 연구 목적 4

C. 연구 가설 4

D. 용어 정의 4

Ⅱ. 문헌고찰 6

A. 뇌졸중 입원 환자의 우울과 스트레스 6

B. 향기요법 9

Ⅲ. 연구방법 13

A. 연구 설계 13

B. 연구 대상 13

C. 연구 진행 절차 14

D. 연구 도구 16

E. 자료 분석 방법 17

F. 연구의 제한점 17

Ⅳ. 연구결과 18

A. 실험군과 대조군의 동질성 비교 18

1. 대상자의 일반적 특성 18

2. 대상자의 질병관련 특성 20

3. 대상자의 우울과 스트레스에 대한 동질성 비교 22

B. 가설검정 23

1. 향기요법이 뇌졸중 환자의 우울 정도에 미치는 영향 23

2. 향기요법이 뇌졸중 환자의 스트레스 정도에 미치는 영향 24

Ⅴ. 논의 25

Ⅵ. 결론 및 제언 29

A. 결론 29

B. 제언 30

참고문헌 31

부 록 39

ABSTRACT 47
Favorable clinical outcomes of simultaneous ACL reconstruction and UKA or HTO: A systematic surveillance

Field: Medicine (Health Sciences)

Purpose: Outcomes after combination of anterior cruciate ligament (ACL) reconstruction (ACLR) with unicompartmental knee arthroplasty (UKA) or high tibial osteotomy (HTO) have been widely reported, but previous systematic reviews have included articles published before 2000 and do not necessarily reflect recent trends. We conducted a thorough investigation to address (1): What are the recent surgical trends in simultaneous ACLR and UKA or HTO? and (2) What are the issues in these surgeries? based on a comprehensive systematic analysis. Methods: A systematic surveillance was performed in accordance with the PRISMA guideline. The inclusion criteria were as follows: simultaneous ACLR and UKA or HTO for medial osteoarthritis (OA) with ACL deficiency; clinical outcomes and complications recorded; publication date after 2000.A total of 1466 potentially relevant articles were identified; after exclusions, 31 articles that included 744 knees were analyzed. Fourteen articles included 330 knees underwent simultaneous ACLR and UKA (UKA group) and 17 articles included 414 knees underwent simultaneous ACLR and HTO (HTO group). Results: Overall, complications were found in 14 knees (4.2%) in the UKA group and 47 knees (11.3%) in the HTO group. Re-rupture of the ACL was observed in only the HTO group (6 knees: 1.4%). Revision to TKA occurred in 8 knees (2.4%) in the UKA group and 1 knee (0.2%) in the HTO group. No standardized outcome measures for clinical assessment were used for all studies. Conclusion: The systematic surveillance of studies published since 2000 on the outcomes and complications of simultaneous ACLR and UKA or HTO for medial OA with ACL deficiency indicates an increasing number of reports on simultaneous ACLR and HTO or UKA in recent years. Favorable clinical results were achieved in both treatment groups.
Unusual chromosome structure of fission yeast DNA in mouse cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ABSTRACT Chromosomes from the fission yeast Schizosaccharomyces pombe have been introduced into mouse cells by protoplast fusion. In most cell lines the yeast DNA integrates into a single site within a mouse chromosome and results in striking chromosome morphology at metaphase. Both light and electron microscopy show that the yeast chromosome region is narrower than the flanking mouse DNA. Regions of the yeast insert stain less intensely with propidium iodide than surrounding DNA and bear a morphological resemblance to fragile sites. We investigate the composition of the yeast transgenomes and the modification and chromatin structure of this yeast DNA in mouse cells. We suggest that the underlying basis for the structure we see lies above the level of DNA modification and nucleosome assembly, and may reflect the attachment of the yeast DNA to the rodent cell nucleoskeleton. The yeast integrant replicates late in S phase at a time when G bands of the mouse chromosomes are being replicated, and participates in sister chromatid exchanges at a high frequency. We discuss the implications of these studies to the understanding of how chromatin folding relates to metaphase chromosome morphology and how large stretches of foreign DNA behave when introduced into mammalian cells.
Quantitative Proteomics of the Tonoplast Reveals a Role for Glycolytic Enzymes in Salt Tolerance

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract To examine the role of the tonoplast in plant salt tolerance and identify proteins involved in the regulation of transporters for vacuolar Na+ sequestration, we exploited a targeted quantitative proteomics approach. Two-dimensional differential in-gel electrophoresis analysis of free flow zonal electrophoresis separated tonoplast fractions from control, and salt-treated Mesembryanthemum crystallinum plants revealed the membrane association of glycolytic enzymes aldolase and enolase, along with subunits of the vacuolar H+-ATPase V-ATPase. Protein blot analysis confirmed coordinated salt regulation of these proteins, and chaotrope treatment indicated a strong tonoplast association. Reciprocal coimmunoprecipitation studies revealed that the glycolytic enzymes interacted with the V-ATPase subunit B VHA-B, and aldolase was shown to stimulate V-ATPase activity in vitro by increasing the affinity for ATP. To investigate a physiological role for this association, the Arabidopsis thaliana cytoplasmic enolase mutant, los2, was characterized. These plants were salt sensitive, and there was a specific reduction in enolase abundance in the tonoplast from salt-treated plants. Moreover, tonoplast isolated from mutant plants showed an impaired ability for aldolase stimulation of V-ATPase hydrolytic activity. The association of glycolytic proteins with the tonoplast may not only channel ATP to the V-ATPase, but also directly upregulate H+-pump activity.
Aberrant expression of the gastric mucin MUC6 in human pulmonary adenocarcinoma xenografts

Field: Medicine (Health Sciences)

Certain pulmonary adenocarcinomas show gastrointestinal differentiation with the expression of various mucins. The CDX homeobox gene, an intestine-specific transcription factor, is related to gastric carcinogenesis with MUC2 and MUC6 expression. The intestinal mucin MUC2 is expressed in the normal lung, while the gastric mucin MUC6 is not. Previously, we have reported that the expressions of MUC2 and MUC6 were related to a poor prognosis in small adenocarcinomas of the lung. We estimated the expressions of the mucin (MUC2 and MUC6) and CDX (CDX1 and CDX2) to examine how CDX relates to the gastrointestinal mucin production in the pulmonary adenocarcinoma. Thirty-nine human non-small cell lung cancer (NSCLC) xenografts were examined (13 adenocarcinoma, 18 squamous cell carcinoma and 8 large cell carcinoma). Significant expression of the MUC6 gene was observed in 7 out of 39 (17.9%) NSCLC xenografts. The expressions of the MUC6 genes were noted in 6 out of 13 (46.2%) adenocarcinoma xenografts, but only in 1 of 18 (0.06%) squamous cell carcinoma xenografts. The adenocarcinoma xenografts significantly showed higher expression of the MUC6 gene than squamous cell carcinoma xenografts (t-test, p=0.0343). Four adenocarcinoma-xenografts co-expressed both the MUC2 and MUC6 genes, and the residual 2 adenocarcinoma-xenografts expressed only the MUC6 gene. One MUC6 overexpressing squamous cell carcinoma focally contained an adenocarcinoma component. The expression patterns of the gastrointestinal mucins were analogous to gastric cancer. The cellular morphology of these carcinoma xenografts was of the gastric cancer type. The proteins of the MUC2 and MUC6 were immunohistochemically confirmed in the xenografts. The expression of the MUC6 gene was significantly correlated with the expressions of the CDX1 and CDX2 genes in the xenografts (Fisher's test, p<0.0001 and p=0.0005, respectively), while there was no significant association between the expression of the MUC2 and CDX genes. These results suggest that the expression of CDX molecules in the pulmonary carcinogenesis pathway relates to gastric cancerous features of aberrant MUC6 expression.
Mauve is an Old Woman’s Colour: Women’s Visual Representations of Menopause

Field: Social Sciences (Social Sciences)

Asking women to draw menopause began as an interesting adjunct to a larger research study examining understandings of menopause. The author was specifically interested in exploring how the notion of menopause as hormone deficiency came to be established and how it continues to be so staunchly reinforced today. Menopause clinics function as specialist sites often within, or associated with, large tertiary hospitals. The majority of women were attending a menopause clinic to seek help for menopause-related problems. This may seem an obvious statement but it conceals the complexity and uncertainty of problems that many women experience at this stage of their lives. In asking women to draw menopause the author was interested in how they understood menopause, particularly in relation to their management practices. The drawings revealed the multiplicities of women's menopause. The choice of colour in the representations of menopause was important for the women participating.
Metal Oxo-Fluoride Molecules OnMF2 (M = Mn and Fe; n = 1–4) and O2MnF: Matrix Infrared Spectra and Quantum Chemistry

Field: Chemistry (Physical Sciences)

On reacting laser-ablated manganese or iron difluorides with O2 or O3 during codeposition in solid neon or argon, infrared absorptions of several new metal oxo-fluoride molecules, including OMF2, (η1-O2)MF2, (η2-O3)MF2, (η1-O2)2MF2 (M = Mn and Fe), and O2MnF, have been observed. Quantum chemical density functional and multiconfiguration wavefunction calculations have been applied to characterize these new products by their geometric and electronic structures, vibrations, charges, and bonding. The assignment of the main vibrational absorptions as dominant symmetric or antisymmetric M-F or M-O stretching modes is confirmed by oxygen isotopic shifts and quantum chemical calculations of frequencies and thermal stabilities. The tendency of Fe to form polyoxygen complexes in lower oxidation states than the preceding element Mn is affirmed experimentally and supported theoretically. The M-F stretching frequencies of the isolated metal oxo-fluorides may provide a scale for the local charge on the MF2 sites in active energy conversion systems. The study of these species provides insights for understanding the trend of oxidation state changes across the transition-metal series.
From Surveillance to Sentencing: Evaluating AI's Role in Indian Criminal Justice

Field: Social Sciences (Social Sciences)

Abstract Artificial Intelligence (AI) is rapidly transforming criminal investigations across the globe, emerging as a powerful tool in the fight against crime. In India, the adoption of AI technologies is accelerating, particularly in response to the growing prevalence of cybercrime and the exponential increase in digital evidence. Traditional investigative methods often struggle to cope with the volume and complexity of modern criminal activity, prompting Indian law enforcement agencies to explore AI-driven solutions. Technologies such as predictive policing, facial recognition, natural language processing, and data analytics offer the potential for faster response times, higher accuracy, and improved investigative outcomes. Predictive algorithms can identify crime-prone areas, while facial recognition systems can swiftly pinpoint suspects—tasks that once required significant time and manpower. Additionally, AI shows promise in addressing cybercrime, one of the most formidable challenges currently facing Indian authorities. However, the integration of AI into criminal investigations raises critical concerns regarding privacy, surveillance, data protection, and algorithmic bias. India's regulatory framework for AI use in law enforcement remains underdeveloped, posing significant risks to civil liberties and fundamental rights. This paper critically examines the potential benefits and inherent risks of deploying AI in criminal investigations within the Indian context and highlights key legal, ethical, and policy challenges that must be addressed to ensure its responsible and equitable implementation.
<title>Lanthanide mixed ligand chelates for DNA profiling and latent fingerprint detection</title>

Field: Chemistry (Physical Sciences)

It is our aim to develop a universally applicable latent fingerprint detection method using lanthanide (rare-earth) complexes as a source of luminescence. Use of these lanthanide complexes offers advantages on several fronts, including benefits from large Stokes shifts, long luminescence lifetimes, narrow emissions, ability of sequential assembly of complexes, and chemical variability of the ligands. Proper exploitation of these advantages would lead to a latent fingerprint detection method superior to any currently available. These same characteristics also lend themselves to many of the problems associated with DNA processing in the forensic science context.
Incorporating the transmission power flow into Singapore Market Clearing Model (MCM)

Field: Energy (Physical Sciences)

The Market Clearing Model (MCM) software is a tool to dispatch the bidding offers from Generation Companies in the Singapore real-time wholesale electricity market. Before this study, the MCM has been developed by researchers in DNV GL. The version of this model does not include the transmission power flow. It means there is a lack of accurate indication for the real market practice. In this report, the transmission power flow is considered in this model. The model will have an improvement by incorporating the calculation of transmission power flow into the previous computing framework. The new MCM will produce a different optimal dispatch schedule and the Market Clearing Price (MCP) of energy, reservation and regulation. Unlike the previous MCM, each node has its Locational Marginal Price (LMP) while in the previous version the whole system only has one LMP value. This model is implemented in the MatLab environment with linear programming. The simulation data is used to validate the effectiveness of the MCM. The sensitivity analysis has been conducted to assess the influence from varying certain factors, such as the various effects on the network benefit.
Peer Review #3 of "Metagenomic investigation of the equine faecal microbiome reveals extensive taxonomic diversity (v0.2)"

Field: Veterinary (Health Sciences)

Background.The horse plays crucial roles across the globe, including in horseracing, as a working and companion animal and as a food animal.The horse hindgut microbiome makes a key contribution in turning a high fibre diet into body mass and horsepower.However, despite its importance, the horse hindgut microbiome remains largely undefined.Here, we applied cultureindependent shotgun metagenomics to thoroughbred equine faecal samples to deliver novel insights into this complex microbial community.Results.We performed metagenomic sequencing on five equine faecal samples to construct 123 high-or medium-quality metagenome-assembled genomes from Bacteria and Archaea.In addition, we recovered nearly 200 bacteriophage genomes.We document surprising taxonomic diversity, encompassing dozens of novel or unnamed bacterial genera and species, to which we have assigned new Candidatus names.Many of these genera are conserved across a range of mammalian gut microbiomes.Conclusions.Our metagenomic analyses provide new insights into the bacterial, archaeal and bacteriophage components of the horse gut microbiome.The resulting datasets provide a key resource for future high-resolution taxonomic and functional studies on the equine gut microbiome.
Dual Function of CCAT2 in Regulating Luminal Subtype of Breast Cancer Depending on the Subcellular Distribution

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Breast cancer is the most common cancer in women around the world. Emerging evidence has indicated the important roles that non-coding RNAs play in regulating tumor development and progression in breast cancer. Herein, we found a dual function of long non-coding RNA (LncRNA) CCAT2 in the luminal subtype of breast cancer, depending on its subcellular distribution. CCAT2 showed an overall downregulation in the tumor tissues from luminal breast cancer patients. Transient overexpression of CCAT2 in the luminal subtype of breast cancer cell MCF-7 or T47D significantly suppressed cell proliferation in vitro and inhibited tumor growth in vivo. Gene expression analysis of cancer stem cell markers including OCT4, NANOG, h-TERT, SOX2 and KLF4; flow cytometry analysis of breast cancer stem cell population, and mammosphere formation assay demonstrated inhibition of cancer cell stemness with transient transfection of CCAT2 in which exogenous CCAT2 mainly distributed in the cytoplasm and regulated miR-221-p27 signaling via RNA sequence interaction. However, overexpression of CCAT2 in MCF-7 cells through pMX retroviral nuclear expression vector accumulated CCAT2 in the nucleus, leading to upregulation of OCT4-PG1, a pseudogene of stem gene OCT4, thereby promoting the cancer cell stemness. In conclusion, the current study, for the first time, revealed a dual function of lncRNA CCAT2 as a tumor suppressor or oncogene depending upon its subcellular distribution. It also demonstrated the regulatory mechanism of cytoplasmic CCAT2 in suppressing tumorigenesis in the luminal subtype of breast cancer.
Rupintrivir Reveal the Roles of Catalytically Important Residues

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

EV71 is the primary pathogenic cause of hand-foot-mouth disease (HFMD), but an effective antiviral drug currently is unavailable. Rupintrivir, an inhibitor against human rhinovirus (HRV), has potent antiviral activities against EV71. We determined the high-resolution crystal structures of the EV71 3Cpro/rupintrivir complex, showing that although rupintrivir interacts with EV71 3Cpro similarly to HRV 3Cpro, the C terminus of the inhibitor cannot accommodate the leaving-group pockets of EV71 3Cpro. Our structures reveal that EV71 3Cpro possesses a surface-recessive S2 pocket that is not present in HRV 3Cpro that contributes to the additional substrate binding affinity. Combined with mutagenic studies, we demonstrated that catalytic Glu71 is irreplaceable for maintaining the overall architecture of the active site and, most importantly, the productive conformation of catalytic His40. We discovered the role of a previously uncharacterized residue, Arg39 of EV71 3Cpro, that can neutralize the negative charge of Glu71, which may subsequently assist deprotonation of His40 during proteolysis. Hand-foot-mouth disease (HFMD) is a serious rapid-spread disease caused mainly by enterovirus 71 (EV71), coxsackie A16, as well as other enteroviruses (10). In China alone, around 1 million people (mostly children) were diagnosed with HFMD in the past year
Uhandumin children with autism spectrum disorders or language impairment

Field: Psychology (Social Sciences)

Atypical pragmatic language is often present in individuals with autism spectrum disorders (ASD), along with delays or deficits in structural language. This study investigated the use of the “fillers” uh and um by children ages 4–8 during the autism diagnostic observation schedule. Fillers reflect speakers' difficulties with planning and delivering speech, but they also serve communicative purposes, such as negotiating control of the floor or conveying uncertainty. We hypothesized that children with ASD would use different patterns of fillers compared to peers with typical development or with specific language impairment (SLI), reflecting differences in social ability and communicative intent. Regression analyses revealed that children in the ASD group were much less likely to use um than children in the other two groups. Filler use is an easy‐to‐quantify feature of behavior that, in concert with other observations, may help to distinguish ASD from SLI. Autism Res 2016, 9: 854–865 . © 2016 International Society for Autism Research, Wiley Periodicals, Inc.
A high-performance overlay architecture for pipelined execution of data flow graphs

Field: Computer Science (Physical Sciences)

A major issue facing the widespread use of FPGAs as accelerators is their programmability wall: the difficulty of hardware design and the long synthesis times. Overlays-pre-synthesized FPGA circuits that are themselves reconfigurable - promise to tackle these challenges. We design and evaluate an overlay architecture, structured as a mesh of functional units, for pipelined execution of data-flow graphs (DFGs), a common abstraction for expressing parallelism in applications. We use data-driven execution based on elastic pipelines to balance pipeline latencies and achieve a high f MAX , scalability and maximum throughput. We prototype two overlays on a Stratix IV FPGA: a 355 MHz 24×16 integer overlay and a 312 MHz 18×16 floating-point overlay. We also design a tool that maps DFGs to overlays. We map 15 DFGs and show that the two overlays deliver throughputs of up to 35 GOPS and 22 GFLOPS, respectively. We also show that DFG mapping is fast, taking no more than 6 seconds for the largest DFG. Thus, our overlay architecture raises the level of abstraction of FPGA programming closer to that of software and avoids lengthy synthesis time, easing the use of these devices to accelerate applications.