jimnoneill/paper-to-field-training huggingface dataset:
Ultrasensitive Sandwich-Type Electrochemical Aptasensor for Dual Detection of Lung Cancer Biomarkers

Field: Chemical Engineering (Physical Sciences)

The fabrication and signal amplification play important roles in electrochemical biosensors to achieve high sensitivity and low cost. In this study, a sandwich-type electrochemical aptasensor for dual lung cancer biomarkers, neuron-specific enolase (NSE) and epidermal growth factor receptor (EGFR), was constructed based on black phosphorus–gold nanocomposites (BP–AuNCs) and aptamers. BP–AuNCs nanocomposites were synthesized by an in situ reduction process without any reducing agent and decorated on the surface of the detachable spherical working electrodes (WEs). The signal amplification was obtained by the good electrical conductivity of BP–AuNCs, as well as the large number of binding sites provided for the capture aptamers (Apt 1). Moreover, the addition of secondary aptamers (Apt 2) formed the sandwich-type aptasensor to obtain a dual signal amplification. The resulting signal by the differential pulse voltammetry (DPV) analysis in the solution containing ferroferricyanide redox probe (Fe(CN) $_{{6}}{)}^{\text {3-/4-}}$ is proportional to the concentration of the target biomarkers. The electrochemical aptasensor platform was simply fabricated on the cloth substrate by screen printing. Under the optimized conditions, the proposed aptasensor was used in the simultaneous detection of two lung cancer biomarkers, NSE and EGFR. Good linear detection was obtained in a range of 1–400 ng/mL (NSE) and 1–600 ng/mL (EGFR) with ultralow detection limits of 0.1 ng/mL (NSE) and 0.6 ng/mL (EGFR), respectively. Experimental results display good selectivity, stability, and accuracy, thus providing a promising low-cost platform in the preliminary estimates and diagnosis of lung cancer at early stages.
Philosophy, Dogma, and Exegesis in Medieval Ashkenazic Judaism: The Evidence of Sefer Hadrat Qodesh

Field: Arts and Humanities (Social Sciences)

During the Middle Ages, each Mediterranean land, from one end of the sea to the other, had its Jewish philosophers. There was one region and one Jewish culture, however, that made no contribution at all to the writing of medieval Jewish philosophy. That was Ashkenazic or Northern European Judaism, the culture of the Jews of England, Northern France, Germany, and Eastern Europe north of the Balkans.
ESTIMATION OF TOTAL PHENOL IN SOME MEDICINAL PLANTS OF MARATHWADA REGION IN MAHARASHTRA

Field: Agricultural and Biological Sciences (Life Sciences)

AnÂ attemptÂ hasÂ beenÂ madeÂ hereÂ toÂ investigateÂ occurrenceÂ ofÂ totalÂ phenol inÂ the leaves , barkÂ andÂ woodÂ Â ofÂ Butea monosperma Â­Lam, MadhucaÂ indica Gmel,Â Mimusops elengi Linn and Syzygium cumini Linn. are medicinally important plants of Marathwada region in Maharashtra. ComparativeÂ accountÂ ofÂ totalÂ phenolÂ contentÂ ofÂ leaves ,bark and wood ofÂ fourÂ speciesÂ revealedÂ that , MadhucaÂ indica wereÂ richÂ ( range 2.156Â to 4.410Â mg / g dry wt. )Â than Butea monosperma (range 1.987 to 4.138 mg / g dry wt.) Â­, Mimusops elengi (range 2.601 to 3.438 mg / g dry wt.)Â and Syzygium cumini (range 1.621 to 3.330Â mg / g dry wt. )Â in all seasons. Key words:Â Total Phenol, Medicinal Plants, Marathwada region.
Photoinduced Localized Phonons and Instantaneous Structure Contributing to Amplified Spontaneous Emission of Conjugated Polymers

Field: Chemistry (Physical Sciences)

Amplified spontaneous emission (ASE), as a microscopic dynamical process, significantly influences the quality of optically pumped conjugated polymeric lasers. Based on the continuous optical pumping that couples with the prominent self-trapping process of conjugated polymer, four localized phonon modes are distinguished in conjugated polymers, all of which greatly contribute to localization of the excited state as well as local distortion along alternating single and double bonds. Consequently, the ultrafast localized distortion of alternating bonds constructs "instantaneous" structures—an effective four-level electronic structure and population inversion—for ASE. It is shown that all the evolving localized vibrational modes possess even parity, which not only makes it highly possible to be probed through the infrared phonon spectrum, but also opens up an opportunity to improve the quantum efficiency of a polymer ASE/laser by modification of localized phonon modes.
Imidazopyridines

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The role of structural features of sulmazole, an imidazo(4,5-b)pyridine, in its inotropic action was examined by comparison with its reduced (4-methylthiophenyl) analog EMD 46512 and the corresponding imidazo(4,5-c)pyridine isomers isomazole and EMD 41000 on isolated guinea-pig papillary muscles and right atria and on Na,K-ATPase and phosphodiesterase III isolated from guinea-pig hearts. The pyridine nitrogen position in sulmazole was crucial for affinity to Na,K-ATPase (IC50 = 350 microM) because the imidazo(4,5-c)pyridines had little effect. Participation of Na,K-ATPase inhibition in sulmazole's inotropic effect (EC50 = 180 microM) was suggested by synergism with the Na channel activator germitrine. The methylsulfinyl oxygen at the phenyl ring decreased the affinity to Na,K-ATPase of sulmazole 40-fold: The reduced analog EMD 46512 was a potent inhibitor of Na,K-ATPase (IC50 = 8.5 microM) and a more potent inotropic agent (EC50 = 8.2 microM) that appeared to act predominantly through Na,K-ATPase inhibition. Micromolar through Na,K-ATPase inhibition. Micromolar IC50s for inhibition of phosphodiesterase III were 49 (sulmazole), 34 (EMD 46512), 18 (isomazole), and 13 (EMD 41000). Participation of this mechanism in the inotropic effect of sulmazole, isomazole, and EMD 41000, but not EMD 46512, was indicated by augmentation of slow action potentials, synergism with histamine, inhibition by carbachol, and (with the exception of EMD 41000) a positive chronotropic effect on the right atrium. Sulmazole appeared to combine the actions of its 4-methylthiophenyl analog EMD 46512 (an inhibitor of Na,K-ATPase) and of its imidazo(4,5-c)pyridine isomer isomazole (an inhibitor of phosphodiesterase III).
Structure and High Temperature Thermoelectric Properties of Delafossite-Type Oxide CuFe1-xNixO2 (0 ≤x ≤0.05)

Field: Materials Science (Physical Sciences)

We have investigated crystal structure of delafossite-type oxide CuFe1-xNixO2 (0 ≤x ≤0.05) and measured its thermoelectric properties at high temperatures ranging from 300 and 1100 K. The lattice parameter a of the Ni2+-doped samples is nearly equal to that of CuFeO2, while the lattice parameter c of the Ni2+-doped samples increases. Nearly constant a-axis is due to the decrease of (Fe/Ni)–O distance and simultaneous increase of O–(Fe/Ni)–O angle. Increase of the c-axis is due to the increase of Cu–O distance in the Ni2+-doped samples. The valence states of the Fe- and Cu-sites are calculated from bond valence summation. The valence state of the Fe-site in the Ni2+-doped samples is larger than that of CuFeO2, an indication of hole doping in the Fe-site. This increase of hole carriers enhances the electrical conductivity σ. The highest electrical conductivity is 18 S/cm. Although the Seebeck coefficient S decreased by Ni2+ doping, the S is still high value (S>250 µV/K). The thermal conductivity κ of CuFe1-xNixO2 is relatively high (κ>4 W/mK). The maximum dimensionless figure of merit ZT=σS2T/κ=0.14 is obtained with the sample of x=0.01 at 1100 K, being higher than that of the polycrystalline γ-Na0.7CoO2. There is no significant evaporation of the constituent elements after the heat cycles.
Investigating the usability of a screen reader and mental models of blind users in the Windows environment

Field: Health Professions (Health Sciences)

The study explored blind users' mental models and strategies in coping with the Windows environment and investigated the relationship between users' mental models and usability problems they face when using a screen reader. The study found that blind users possess a functional or structural mental model or a combination thereof. Blind users also have a rich and highly procedural strategy for coping with a new Windows environment and application. Users' established mental models developed from using a familiar screen reader were found to contribute to problems in using a new screen reader.
ON A SINGULARLY PERTURBED, COUPLED ELLIPTIC-ELLIPTIC PROBLEM

Field: Mathematics (Physical Sciences)

To Professor Silviu Sburlan, at his 60 ’ anniversary The behavior of the solution of the below problem (Eɛ), (BCɛ), (T Cɛ) is studied when the small parameter ɛ tends to 0. 1. Introduction. We consider the following coupled boundary value problem of elliptic-elliptic
Mathematical Model Used to Compute Packet Energy Consumption-Based Control Topology for WSN

Field: Computer Science (Physical Sciences)

Several recent scientific papers have been proposed on power consumption in Wireless Sensor Networks (WSN). Still, the work focused on control topologies of WSN in the field of increasing and prolonging the whole network is limited. This results from their function as routers that send data from edge nodes to the sink. The nodes around the sink node quickly die while delivering much data through intermediate nodes from one node to the sink node. The network lifetime was reduced because the sensor nodes adjacent to the sink consume twice as much power as the others. This problem is not recognized and addressed in more visual detail by the authors. The nodes closest to the sink node will die first. Therefore, this paper proposed a mathematical model to represent packet energy consumption with control topology for WSN. Due to the simulation, more than 90% of sensors are still operational and optimally arranged. The overall battery power remaining in the sensors was greater than 70%.
Theodore Watts-Dunton’s Aylwin and the reduplications of Romanticism

Field: Arts and Humanities (Social Sciences)

This chapter introduces and reconsiders the achievement of Theodore Watts-Dunton, poet, critic and novelist, before focusing on his best-selling but now neglected novel Aylwin. A meditation on the lost woman, the novel offers as part of its end-of-century rearticulation of Romantic values a particularly arresting treatment of woman-as-aesthetic image reduplicated through portraiture and mesmeric therapy, and reinstates the often missing 'pathological' element of the Romantic Image. The chapter traces the uncanny structures of corporeal doubling, repetition and transference which Watts-Dunton allies with Coleridge's 'Christabel' to consider the novel's strategic defence of the Romantic imagination, and shows how it reveals the lines of a Romantic genealogy that extends from Coleridge through Rossetti to writers such as Yeats.
Gendering Balkanisms: Gender, Culture, and Class in Nineteenth-Century Women's Travelogues in the Balkans

Field: Arts and Humanities (Social Sciences)

This article links nineteenth-century travelogues about the Balkans written by European women travelers—Dora d'Istria, Maria Karlova, Emily Strangford, and Paulina Irby and Georgina Mackenzie—both to a broader historical discourse called Balkanism and to the socio-historical contexts of the authors themselves. It examines the ways in which these texts adopted existing hegemonic dichotomies of Balkanism concerning culture, ethnicity/religion, and gender and whether they set new paths for Balkanist discourse. Written during the time of anti-Ottoman uprisings and nation-building movements, the travelogues expressed diverse humanitarian, Christian, feminist, anti-imperial/Turkish and other agendas and discussed the crucial role of (Balkan) women in it. Through a particular focus on domestic life and the lives of women, these women travelers also spoke of their own position in society, bringing to light their struggle for equality in traveling, writing, and participating in broader political and social life, and in that way disturbed the male-centered Balkanist discourse.
The Popular Legitimisation of the Mafia: The Beati Paoli and the Mafioso as an Avenger

Field: Social Sciences (Social Sciences)

Very soon after the short period in which the attention of the institutions and national public opinion had been captured by the trials of the Notarbartolo case, the mafia became part of the normality of the Sicilian situation once more, and any investigative activity was very low-key. The reasons for this 'normalisation' can be attributed principally to the deep roots that the Sicilian cosche had grown within the political structures of the island, and thanks also to the increased suffrage that the left-wing parties had erroneously considered the best antidote to the mafia (Pezzino 1995, p.161). Links between the mafia and members of the island's politics were not isolated, especially since the cosche even infiltrated those movements which fought for a fair distribution of public land, such as the Sicilian Fasci. An eloquent example is the case of Vito Cascio Ferro, an important mafioso of the day, who was director of the Fascio in Bisacquino, while other gabelloti, directly involved with the mafia, promoted the movement at Contessa Entellina (Block 1986, pp. 121–26). A clear attempt to anaesthetise the problem of the mafia and its dangers emerges from the island's police reports. In fact, the institutions, almost forgetful of the results obtained by previous investigations, reconfirmed the old refrain, that the mafia was not a criminal organisation.
Supplemental Material, jspr-17-012-File002 - Communal one day, exchange the next: Daily relationship orientation mediates the influence of perceived stress on constructive interactions in close relationships

Field: Psychology (Social Sciences)

Supplemental Material, jspr-17-012-File002 for Communal one day, exchange the next: Daily relationship orientation mediates the influence of perceived stress on constructive interactions in close relationships by Tianyuan Li and Helene H. Fung in Journal of Social and Personal Relationships
Social Media Use and its impact on mental health among adolescents: A cross sectional study of Kathmandu

Field: Medicine (Health Sciences)

Background: Numerous studies have highlighted the link between excessive social media use and negative mental health outcomes. Purpose: to identify the impact of use of social media among adolescents’ studying in secondary schools of Kathmandu. Methods: Cross sectional study design was used to identify the impact of use of social media among adolescents’ studying in three secondary schools of Kathmandu. Students of aged 13 to 17 studying in class 8, 9 and 10 who consented to participated and available during time of data collection were selected purposively with the sample size of 327. Self-administered questionnaire developed on extensive literature reviewed consisting of socio-demographic information and social media use information in part one, impact of social media usage on mental health outcome in part two and also part three consisted of standard tool of Generalized Anxiety Disorder-7 (GAD-7). Ethical clearance was obtained from Institutional Review Committee (IRC), YHSA (2079-080-281). Frequency, percentage, mean and standard deviation were calculated for descriptive statistics as well as the Chi-square test was used for inferential statistical analysis of data using SPSS version 26.0. Findings: Among 327 respondents participated, more than half were between 13-15 years with almost same percentage of male and female. Participants (43.4%) favour Facebook and 49.5% begin using social media at ages 9-12 years. More than half of the respondents (52.3%) use social media for 1-3 hours, while 34.6% use it for more than 4-6 hours. This study resulted half of the respondents (50.8%) had minimal anxiety, while 30.6% were experiencing mild anxiety. There has a significant relationship between the duration of social media use and sleep alteration, disruption of morning activities, change in behaviour, distraction in work or study, portrayer in certain image and anxiety among secondary level students in Kathmandu at p-value <0.05. Research Limitation/Practical Implication: These findings underscore the urgent need for targeted interventions aimed at mitigating the negative impacts of excessive social media usage on adolescent mental health. Originality/Value: This study explore the association between social media use and its impact in mental health aspects which includes alteration in sleeping patterns, disruption in regular morning activities, distraction in work or study, change in behavior, media portray of image, experience of cyber bullying and anxiety in Nepali secondary level students.
Effect of magnetic water on strength and workability of high performance concrete

Field: Engineering (Physical Sciences)

Nowadays, concrete is one of the most important and widely used human product. Improving concrete characteristics have always been one of the fundamental subjects for engineers. Improve the physical properties of water, as one of the main elements of concrete, is one way to improve the characteristics of the concrete. When water passes through the magnetic field, its physical quality has changed, it is called Magnetic water. This study examines the effect of the use of magnetized water (MW) with a solenoid current-carrying, on the compressive strength and workability of high performance concrete. The variables of this study were the intensity of magnetic field, the silica fume replacement level and water to cement ratio in different mixes. The results show that using MW increases the workability of concrete about 36% in average.MW in combination with superplasticizer is more effective than MW on workability and compressive strength of concrete. MW had more positive effects on the samples without silica fume. Increasing the intensity of magnetic field improved the workability, 28 and 90 days compressive strength concrete.
Influence of Polymorphism −308 G/A of the Tnf-α Gene on High Mobility Group Box-1 Protein in Rheumatoid and Spondylo-Arthritis Patients

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Single nucleotide polymorphism (SNP) in the human Tumor Necrosis Factor-α(TNF-α) gene promoter, the −308 G/A variant, has been associated with increased TNF-α levels that may amplify the severity of rheumatoid arthritis (RA) and a poor responsiveness to TNF-α blockade therapy. High mobility group box protein (HMGB-1) is a pro-inflammatory cytokine that plays a pivotal role in the pathogenesis of RA and may be an original target of therapy. The aim of this study is to investigate whether the −308 G/A variant of the TNF-α gene is associated with altered expression of HMBG-1. A total of 110 consecutive patients with rheumatoid arthritis and spondylo-arthritis (ankylosing spondylitis, psoriatic arthritis and spondylitis associated with inflammatory bowel disease) referring to the Rheumatology Unit of Messina University Hospital were enrolled. Patients were genotyped for the −308 TNF-α gene promoter polymorphism. Clinical status was also assessed. HMGB-1 and TNF-α mRNA(Real Time PCR) from total blood and plasmatic HMGB-1 (Western Blot analysis) and TNF-α (ELISA) protein were also evaluated. Irrespective of the underlying disease, patients carrying the G/A genotype showed enhanced HMGB-1 and TNF-α mRNA levels and increased circulating concentration of the inflammatory cytokines when compared to patients with G/G genotype. The data suggest that subjects carrying the TNF-α −308G/A genotype have enhanced expression of HMGB-1 protein that may explain, at least in part, the increased severity of the disease.
A Method of Preparing Spores for Fern Cultures

Field: Agricultural and Biological Sciences (Life Sciences)

In growing ferns from spores, it is desirable, and in experimental work essential, to be able to obtain pure cultures of one species. For example, much time might be wasted in carefully growing plants which later turn out to be contaminants. For controlled experiments, contaminating spores of other species may give uncertain results and threaten the validity of the work. Not only are mixtures of spores of other fern species an inconvenience, but spores of mosses, algae, and fungi are likewise troublesome. Often cultures become overgrown with the filamentous protonemata of mosses that shade out the desired fern prothallia. Algae, especially the green and blue-green types, may often take over, enveloping the fern material, killing both prothallia and young sporophytes. Mold fungi also are serious pests that handicap culture work. To allay such contamination, many who grow fern spores are careful to sterilize their culture medium, whether it be soil, nutrient agar, or liquid solution, as ethod of Preparing Spores for Fern Cultures 95
Matrix-isolation study of the pyrolysis of bromochloromethyl-substituted organomercury compounds. Infrared spectra of the bromochlorocarbene andree radicals CCl2Br and CClBr2

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMatrix-isolation study of the pyrolysis of bromochloromethyl-substituted organomercury compounds. Infrared spectra of the bromochlorocarbene andree radicals CCl2Br and CClBr2A. K. Maltsev, O. M. Nefedov, R. H. Hauge, J. L. Margrave, and D. SeyferthCite this: J. Phys. Chem. 1971, 75, 26, 3984–3988Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/j100695a013https://doi.org/10.1021/j100695a013research-articleACS PublicationsRequest reuse permissionsArticle Views28Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Moment categories and operads

Field: Mathematics (Physical Sciences)

A moment category is endowed with a distinguished set of split idempotents,\ncalled moments, which can be transported along morphisms. Equivalently, a\nmoment category is a category with an active/inert factorisation system\nfulfilling two simple axioms. These axioms imply that the moments of a fixed\nobject form a monoid, actually a left regular band.\n Each locally finite unital moment category defines a specific type of operad\nwhich records the combinatorics of partitioning moments into elementary ones.\nIn this way the notions of symmetric, non-symmetric and $n$-operad correspond\nto unital moment structures on $\\Gamma$, $\\Delta$ and $\\Theta_n$ respectively.\n There is an analog of the plus construction of Baez-Dolan taking a unital\nmoment category $\\mathbb{C}$ to a unital hypermoment category $\\mathbb{C}^+$.\nUnder this construction, $\\mathbb{C}$-operads get identified with\n$\\mathbb{C}^+$-monoids, i.e. presheaves on $\\mathbb{C}^+$ satisfying strict\nSegal conditions. We show that the plus construction of Segal's category\n$\\Gamma$ embeds into the dendroidal category $\\Omega$ of Moerdijk-Weiss.\n