jimnoneill/paper-to-field-training huggingface dataset:
Theranostic nanoparticles and their applications in Alzheimer’s disease

Field: Medicine (Health Sciences)

Nanotechnology is the field of science that investigates materials at the atomic scale and designs mate5 rials with unique qualities via changes in their molecular features. Nanomaterials, which can participate actively in several industrial sectors, provide numerous advantages across every field. Nanomedicine is a medical application of nanotechnology to improve health. It aims to provide an early diagnosis and targeted treatment of diseases with high efficacy. Theranostic nanoparticles are established by combining diagnostic and therapeutic agents within the same nanoparticle. The imaging agent (diagnostic) offers insights into the location and severity of the pathological cells, while the therapeutic agent (therapy) administers lethal medication dosages to the same affected cells. Theranostic nanoparticles, which can be prepared in many types (iron oxide nanoparticles, polymeric nanoparticles, quantum dots, carbon nanotubes, etc.), can be used in compatibility with imaging devices (Positron Emission Tomography (PET), magnetic resonance imaging (MRI) etc.). These nanoparticles constitute an important target for the treatment of many diseases, such as neurodegenerative disorders, where organ pathology is out of reach without invasive methods. Therefore, this innovative technology, which is capable of diagnosing and predicting illnesses at the molecular level, facilitates early diagnosis and treatment, prevents patients from undergoing unneeded interventions, and diminishes superfluous pharmaceutical expenditures within the healthcare system, thus yielding more effective clinical outcomes. The design of theranostic nanoparticles according to the context5dependent necessities is crucial and valuable for the effectiveness of targeted and personalised medicine. In this review, we discuss the types and properties of theranostic nanoparticles, imaging technologies, and their applications in Alzheimer's Disease treatment.
E-learning as a Tool for Human Resource Development. Case ABB

Field: Business, Management and Accounting (Social Sciences)

The rapid change of knowledge-intensive and technology-oriented working life requires continuous development. At the same time, new technology can be seen as an enabling factor in finding solutions to this challenge. One potential tool for human resource development is e-learning, credit-granting education or training courses delivered via audio, video, or computer technologies such as the Internet. Many organizations have taken e-learning methods in use, or are interested in using e-learning in their organizations. One of the most obvious benefits of e-learning is the tremendous cost-saving because there will be no travel costs or lost working hours. However, e-learning is sometimes interpreted in a narrow sense as referring to process of delivering digital information and study materials to users through electronic media. Oversimplifying the notions of knowledge and learning can easily lead to misunderstandings and disappointments. At their best, e-learning environments have the potential to support cognitive, social, motivational, and affective processes of learning. \n\nThis study aims to find out how to build an effective e-learning environment. It is done by reviewing the literature of pedagogical aspects of workplace learning in general and e-learning in particular. As e-learning in the workplace always is concerned with adult learning, adult learning theories should form the basis for the design of e-learning environment in the workplace. The creation of motivating, flexible and diverse multimedia technology represents important challenge in building effective e-learning environments. \n\nThe study draws a categorization for critical phases of designing and implementing e-learning effectively. The interviews are carried out to find evidence of importance of the four phases of designing and implementing e-learning. The total amount of respondents was 14, out of which ten via e-mail and four face-to-face. The results of the study indicate that all four phases are needed in designing and implementing e-learning effectively. The case company succeeded in two phases out of four, but many weaknesses (such as lack of interactivity) were reported in the interviews.
Unveiling the Masquerade: Pulmonary Mycosis Mimicking Pulmonary Malignancy- A Case Series

Field: Medicine (Health Sciences)

Fungal pneumonia or pulmonary mycosis is a fungal infection of the lungs [1]. It can be caused by an endemic pathogen in immunocompetent hosts or an opportunistic agent in immunocompromised patients or a combination of both. Among the myriads of pathogens implicated in pulmonary mycosis, Aspergillus spp, Candida spp, Coccidioides spp, and Pneumocystis jiroveci are more prevalent [2]. Pulmonary mycoses present a significant clinical challenge due to the wide-ranging etiology and potential for severe complications.
The Fictional Lives of the Schumanns

Field: Arts and Humanities (Social Sciences)

Using two recent biographical novels as examples, this chapter argues that the fictional narratives created by novelists can give literary meaning to the Schumanns' lives and can explicitly address universal themes that scholarly biographers can only hint at. In Clara Janice Galloway turns her heroine's life into a feminist Bildungsroman and examines the relationship between Clara Schumann's musical career and her emotional development. J. D. Landis bases Longing on an early 19th‐century fictional genre as well, in this case the early Romantic novel, as he explores the intersections between consciousness, reality, creativity, and madness. Biographical novels are often criticized for blurring fact and fiction as they freely reconstruct the personalities of their subjects, and it is clearly the case that the Schumanns in Longing are not the same characters as the Schumanns in Clara. But the historical narratives of scholarly biographers can also portray the same character in ways that are incompatible with one another, as illustrated by contrasting the accounts of an episode in Schumann's life by two of his biographers, John Daverio and John Worthen. The chapter uses the recent controversy about the diagnosis of Robert Schumann's final illness to compare the genres of the biographical novel and the scholarly biography. The two genres are complementary, and each can potentially contribute in different ways to our understanding of the Schumanns' lives.
Electrophysiologic assessment of (central) auditory processing disorder in children with non-syndromic cleft lip and/or palate

Field: Neuroscience (Life Sciences)

Cleft of the lip and/or palate is a common congenital craniofacial malformation worldwide, particularly non-syndromic cleft lip and/or palate (NSCL/P). Though middle ear deficits in this population have been universally noted in numerous studies, other auditory problems including inner ear deficits or cortical dysfunction are rarely reported. A higher prevalence of educational problems has been noted in children with NSCL/P compared to craniofacially normal children. These high level cognitive difficulties cannot be entirely attributed to peripheral hearing loss. Recently it has been suggested that children with NSCLP may be more prone to abnormalities in the auditory cortex. The aim of the present study was to investigate whether school age children with (NSCL/P) have a higher prevalence of indications of (central) auditory processing disorder [(C)APD] compared to normal age matched controls when assessed using auditory event-related potential (ERP) techniques. School children (6 to 15 years) with NSCL/P and normal controls with matched age and gender were recruited. Auditory ERP recordings included auditory brainstem response and late event-related potentials, including the P1-N1-P2 complex and P300 waveforms. Initial findings from the present study are presented and their implications for further research in this area — and clinical intervention — are outlined.
Improved motor function with Bowen therapy for rehabilitation in chronic stroke: a pilot study

Field: Health Professions (Health Sciences)

INTRODUCTION: Bowen therapy is an established complementary therapy with anecdotal reports of effectiveness. However, there is limited published research to substantiate safety or effectiveness. This is a pilot study to explore the potential impact of Bowen therapy in chronic stroke. METHODS: A case series of 14 people with chronic stroke were offered 13 sessions of Bowen therapy over a three-month period. RESULTS: Motor assessments of the 13 people who participated showed improvements—gross motor function trended to improvement; SF-36 role-physical, physical health summary scale and total SF-36 scores showed statistically significantly improvements. However, grip strength reduced. CONCLUSIONS: In this pilot study, Bowen therapy was associated with improvements in neuromuscular function in people with chronic stroke. At this stage of study, it is not possible to conclude that there is definite benefit; however the results suggest that exploration through further research is appropriate. KEYWORDS: Bowen Therapy; stroke; rehabilitation
Research Article Solid State Fermentation of a Raw Starch Digesting Alkaline Alpha-Amylase from Bacillus licheniformis RT7PE1 and Its Characteristics

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Copyright © 2014 Romana Tabassum et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The thermodynamic and kinetic properties of solids state raw starch digesting alpha amylase from newly isolated Bacillus licheniformis RT7PE1 strain were studied.The kinetic values
Laparoscopic technique of modified extraperitoneal (retrotransversalis) end colostomy for abdominoperineal excision

Field: Medicine (Health Sciences)

Abstract Aim To describe the technique of a modified extraperitoneal retrotransversalis end colostomy as part of a laparoscopic abdominoperineal excision ( APR ). Method The colostomy site is preoperatively chosen and used intra‐operatively for a trocar. After the rectum has been mobilized the descending colon is freed. The peritoneal margin is gently grasped and the parietal peritoneum and extraperitoneal together with the transversalis fascia are separated from the transverse abdominal muscle fibres upwards for 3–4 cm aiming at the trocar site to form the extraperitoneal retrotransversalis canal. The stoma site trocar is partially withdrawn and its head is turned laterally until its tip is positioned in the layer between the abdominal wall muscles and underlying transversalis and extraperitoneal fascia together with the parietal peritoneum. The CO 2 source can be attached so that the gas helps to separate the layers, after which the colostomy trephine is formed at the site of the trocar, the grasper is inserted to gently deliver the blunt end of the descending colon through the canal and the end colostomy is formed in a usual way. Results No procedure‐specific complications were noted in 39 patients who had laparoscopic APR with extraperitoneal retrotransversalis end colostomy from 2009 to 2016. In 23 patients who survived for 3.7 ± 1.7 years after surgery there were no clinical or CT signs of parastomal hernia or prolapse. Conclusion This single‐institution retrospective case series demonstrates that laparoscopic extraperitoneal retrotransversalis end colostomy is feasible, safe and effective in preventing parastomal hernias and stomal prolapse.
School of Nursing, Mkar Benue State 2022/2023 Admission Form/Registration Form is out, ☎ 07065086538 for more details on how to apply and register online

Field: Nursing (Health Sciences)

School of Nursing, Mkar Benue State 2022/2023 Admission Form/Registration Form is out, ☎️ 07065086538 for more details on how to apply and register online
Regularization techniques: A comparative analysis of Ridge, Lasso, and Elastic Net approaches in predicting mental health consequences using mental health survey dataset

Field: Psychology (Social Sciences)

This study investigated the demographic distribution, predictor relationships, and model performance concerning factors influencing work interference among employees. A Chi-square goodness-of-fit test revealed a significant gender imbalance in the sample, with 60% males and 40% females (χ² = 6.00, p = 0.014), indicating a deviation from an expected equal distribution. Despite this, gender differences had minimal effect on the main outcomes. Variance Inflation Factor (VIF) analysis confirmed the absence of multicollinearity among predictors, with the maximum VIF recorded at 2.10 and the mean VIF at 1.45. Cross-validation of Ridge, LASSO, and Elastic Net regression models produced low Root Mean Squared Error (RMSE) values, with Ridge Regression achieving the best fit (RMSE = 4.74). Pseudo R-squared values ranged between 0.42 and 0.44, highlighting the models' moderate explanatory power. Standardized coefficients identified Job Stress as the most influential predictor, followed by Workload, Support from Supervisor, Work-Life Balance, Organizational Commitment, and Job Autonomy. The findings underscore the critical role of reducing stress and workload to minimize work interference and improve organizational productivity. Recommendations include strategic interventions targeting stress management and balanced work demands, alongside improving supervisory support structures.
Predicting Accrual Achievement: Monitoring Accrual Milestones of NCI-CTEP–Sponsored Clinical Trials

Field: Medicine (Health Sciences)

Abstract Purpose: The need to increase the number oncology clinical trials with sufficient enrollments is a well-known issue, particularly for trials targeting therapeutic applications. It is critical to identify early predictors of eventual study accrual achievement. Experimental Design: All nonpediatric phase I, I/II, II, and III therapeutic studies supported by the National Cancer Institute Cancer Therapy Evaluation Program (NCI-CTEP) between 2000 and 2007 (n = 764) were analyzed for accrual performance. Accrual achievement is defined as those enrolling 100% or more of the stated minimum accrual goal at the time of trial closure. Two accrual milestones were analyzed per trial: time to first patient enrollment and expected time to accrual goal. Multivariate logistic regression analysis was used to calculate the OR with respect to the likelihood of clinical trial accrual achievement. Results: A total of 81.5% (n = 623) of the trials did not achieve the projected accrual goals within the anticipated accruing period. Furthermore, 37.2% (n = 284) of trials failed to achieve the minimum projected accrual at study closure regardless of time the trial was open. Trials that accrue the first enrollment beyond 2 months (n = 379, 49.6%) are significantly less likely to achieve the accrual performance than those trials that enroll patients under 2 months (OR: 0.637, 95% CI: 0.464–0.875, P = 0.005). Of the studies that are open beyond the anticipated enrollment period (n = 603), those do not achieve at least 60.0% of the projected minimum accrual (n = 391, 64.8%) have a significantly less likelihood of achieving final accruals by study closure (OR: 0.190, 95% CI: 0.055–0.652, P = 0.008). Conclusions: The time to first patient enrollment and expected time to accrual goal are shown to be valid measures to evaluate the likelihood of achieving the minimum projected accrual. Clin Cancer Res; 17(7); 1947–55. ©2011 AACR.
Bovine longissimus muscle tenderness as affected by postmortem aging time, animal age and sex

Field: Agricultural and Biological Sciences (Life Sciences)

ABSTRACT Strip loins were removed from 10 bulls and 10 steers ∼14 mo old and from 10 cows ≥ 44 mo. Samples were removed at 3, 7, 14, and 28 days postmortem. Shear‐force values were measured. Sensory evaluation was done by a 15‐member trained panel. Animal age and postmortem aging time had more influence on tenderness attributes than did sex of the animal. Increased postmortem aging time improved tenderness attributes regardless of sex or age.
REORIENTASI PEMBELAJARAN PENDIDIKAN AGAMA ISLAM DENGAN PENDEKATAN LIFE SKILLS

Field: Arts and Humanities (Social Sciences)

Life Skills education as one form of alternative approach that develops the capability of graduated quality. The implementation of Life Skills education is part of school reform. One of them through reorientation of learning is focused on the learning of Islamic religious education in principle to manage the curriculum applicable so that life skills can be grown programmed. In the learning process can be a task or project that is a tool to practice integrating competence and life skills in a form of problem-solving contextual in the material being studied.
The Application of HACCP Model for Mechanically Separated Poultry (Turkish with English Abstract)

Field: Agricultural and Biological Sciences (Life Sciences)

Hazard Analysis Critical Control Point (HACCP) system is applied in the critical control point to put under control of the foods safety at any point in afood&#039;s production--from its raw state to consumption. HACCP is a preventing system to determine and put under control problems before hazardous or critical situations could occur. So HACCP is designed to take the control at first point in food production system and may be prevented the occurrence of problems at any point for the consumer health. The products such as mechanically deboned poultry (MDP) sensitive of the lipid oxidation and also high microbial load are taken under control with applied of the HACCP at first production steps. In this paper, MDP flow diagram, product description, determination of risk on the production and packaging steps, control, critical control point and HACCP plan were reviewed.
Systematic review protocol: an assessment of the post-approval challenges of autologous CAR-T therapy delivery

Field: Health Professions (Health Sciences)

Introduction Following recent regulatory approvals of two chimeric antigen receptor T-cell (CAR-T) therapies, the field now faces a number of post-approval challenges. These challenges are in some respects defined and, in others, uncertain due to the nascence of the field. At present, information pertaining to such post-approval challenges are scattered in various previous reviews or raised in singular papers reporting experience in working with the therapy. This systematic review is designed to evaluate and summarise the post-approval challenges for robust delivery of CAR-T therapies to inform future work on the optimisation of CAR-T delivery to patients. Methods and analysis We will search Medline, EMBASE (OvidSP), BIOSIS & Web of Science, Cochrane Library, ICER database, NICE Evidence Search, CEA Registry, WHOLIS WHO Library and Scopus for studies published between 2014 and the present. In addition, a Google search for grey literature such as bioprocess blog posts, opinion pieces, press releases and listed companies involved in CAR-T development annual reports will be conducted. Two authors will independently screen the titles and abstracts identified from the search and accept or reject the studies according to the study inclusion criteria and any discrepancies will be discussed and resolved. The quality of the selected literature will be assessed using the Critical Appraisal Skills Programme (CASP) Systematic Review checklist and grey literature will be assessed using the Authority, Accuracy, Coverage, Objectivity, Date, Significance (AACODS) checklist. Data from eligible publications will be categorised using a flowchart and extracted using a data abstraction form. Qualitative and quantitative analysis of the post-approval challenges of CAR-T therapies will be conducted based on the results attained. Ethics and dissemination The executed study will be published in a peer-reviewed journal in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The findings from this review will be used to inform the development of an optimisation model for robust delivery of CAR-T therapies using a systems engineering approach. Trial registration number CRD42018109756.
BSML: Bidirectional Sampling Aggregation-based Metric Learning for Low-resource Uyghur Few-shot Speaker Verification

Field: Computer Science (Physical Sciences)

In recent years, text-independent speaker verification has remained a hot research topic, especially for the limited enrollment and/or test data. At the same time, due to the lack of sufficient training data, the study of low-resource few-shot speaker verification makes the models prone to overfitting and low accuracy of recognition. Therefore, a bidirectional sampling aggregation-based meta-metric learning method is proposed to solve the low-accuracy problem of speaker recognition in a low-resource environment with limited data, termed bidirectional sampling multi-scale Fisher feature fusion (BSML). First, the BSML method was used for effective feature enhancement in the feature extraction stage; second, a large number of similar and disjoint tasks were used to train the models to learn how to compare sample similarity; finally, new tasks were used to identify unknown samples by calculating the similarity of the samples. Extensive experiments are conducted on a short-duration text-independent speaker verification dataset generated from the THUYG-20 low-resource Uyghur with limited data, which comprised speech samples of diverse lengths. The experimental result has shown that the metric learning approach is effective in avoiding model overfitting and improving model generalization, with significant results in the identification of short-duration speaker verification in low-resource Uyghur with few-shot. It also demonstrates that BSML outperforms the state-of-the-art deep-embedding speaker recognition architectures and recent metric learning approach by at least 18%–67% in the few-shot test set. The ablation experiments further illustrate that our proposed approaches can achieve substantial improvement over prior methods and achieves better performance and generalization ability.
Hindu Traditions

Field: Arts and Humanities (Social Sciences)

Abstract This chapter begins with an overview of dharma in Hindu traditions and then the contemporary formulation of dharmic ecology as expressed in classical sources. As depicted in the Bhagavad Gītā, Hindu dharma presents an alternative theocentric articulation of the cosmic common good in a way that confirms and further intensifies a Catholic cosmic common good. Moreover, one of the foremost texts on dharma, The Laws of Manu, provides an excellent focal point for teasing out the relationship among dharma, the good of the ātman (self), and an ethic of ahiṃsā (nonviolence) and vegetarianism. Yet by including all living creatures in the scope of this ātman, dharmic ecology clearly points to the common good of Mother Earth, which suggests that an ātmanocentrism poses an even more intense rejection of anthropocentrism than even a Catholic cosmic common good attains.
Phenotypic and genotypic characteristics of Pseudomonas aeruginosa strains isolated from hospitals in the north-west region of Poland.

Field: Immunology and Microbiology (Life Sciences)

A total of 90 Pseudomonas aeruginosa strains isolated from 4 hospitals in the west-north region of Poland were studied by arbitrarily primed polymerase chain reaction (AP-PCR). AP-PCR results revealed the presence of 11 main groups of patterns (A-K) and 5 unique patterns among isolates. Generally, they were characterized by high resistance to antibiotics tested and significant differences in serogroups and types of growth on Cetrimide Agar medium. It was observed that clonally related strains were isolated from patients within the same ward, among different wards as well as in distant hospitals.