jimnoneill/paper-to-field-training huggingface dataset:
Diagnosis of tuberculous meningitis by immunofluorescence and enzyme immunoassay.

Field: Medicine (Health Sciences)

Cerebrospinal fluid was collected from 29 patients with tuberculous meningitis, 21 and 7 patients with bacterial and viral meningitis and 5 normal subjects. Pressure, aspect, glucose, protein and cellular content of CSF were studied. Detection of acid fast bacilli in direct film stained by Zeil Neilsen (Z.N.) and fluorochrom (Fl.Ch.) and Culture on Lowenstein Jensen media were done. Then specific immunoglobulin G & M to Mycobacteria were assayed by Immunofluorescence (IF using BCG) and by Enzyme Linked Immunosorbant assay (ELISA) using protein-A of M. Tuberculosis. It was found that diagnosis of M. Tuberculosis by CSF culture was more sensitive than by direct CSF film stained with Z.N. or Fl.Ch. stain (positive in 44.8%, 10.3% and 17.2% of cases respectively). It was noticed that the detection of CSF IgG antibodies was more sensitive than IgM antibodies either by IF or ELISA. By comparing ELISA and IF tests for detection of specific anti-mycobacterial immunoglobulin in CSF, it was clear that the sensitivity and specificity of ELISA was more than IF test. A positive result for antimycobacteria IgG antibodies was obtained in 79.3% and 58.6% of cases respectively (p less than 0.05). None of the CSF of normal controls, bacterial and viral meningitis cases gave positive antimycobacteria IgG by ELISA while 9.5% of the CSF of bacterial and 14.3% of aseptic meningitis cases gave positive results with IF. The sensitivity, specificity and predictive value of the described ELISA test, make it useful for early diagnosis of tuberculous meningitis.
VOCABULARY OF THE LEXICAL MINIMUM WHEN LEARNINGUKRAINIAN AS A FOREIGN LANGUAGE (LEVEL A1)(A review of the textbook by Ksenia Borodin and Oksana Turkevych “1000 and 1 Words. Lexical minimum in Ukrainian (A1)” – Slavic Language Education 3 (LANGUAGE-LAB), 2023. – 58 p.)

Field: Arts and Humanities (Social Sciences)

The review characterizes the first edition of the lexical minimum for Ukrainian as a foreign language at the A1 level in accordance with the “Standardized Requirements: Levels of Proficiency in Ukrainian as a Foreign Language A1-C2” (Kyiv, 2020). The structure, grammatical description, and examples of the use of language units contained in the textbook are analyzed. The author explains the criteria used to form the content of the A1 lexical minimum. The lexical material is organized and described with grammatical comments on the alternation of vowels or consonants, the formation of plural forms from other bases, the use of dative and accusative forms of personal pronouns, personal or imperative verb forms, etc. The authors also see this as an element of self-testing for knowledge of the relevant word forms, as well as in the case of forming a context for each vocabulary unit, which demonstrates to users – both students and teachers and scholars in the field of linguistics – the practical application of the lexical minimum. Also noteworthy are the didactic tips on how to work with this educational material (translation tasks, making word cards by topic group, creating tests to check the acquired knowledge at A1 level, etc.) The textbook is an extremely important and relevant work that has been prepared in accordance with modern requirements, didactic achievements and scientific research in the study and teaching of Ukrainian as a foreign language. Undoubtedly, this work will help beginner students, teachers, and all those interested in mastering the Ukrainian language to develop the lexical skills necessary for the realization of communicative activities as soon as possible and in a structured way. Key words: Ukrainian as a foreign language, lexical minimum, beginner level A1, Standardized requirements for levels of proficiency in Ukrainian as a foreign language.
Evaluation on the functional dimensions of the contextual integration at 'Kuala Lumpur Waterfront'

Field: Social Sciences (Social Sciences)

‘Kuala Lumpur Waterfront’ is a term that maybe unfamiliar to many. Kuala Lumpur is a city that originates at the confluence of two rivers, Klang and Gombak River. The waterfront used to be very busy with activities when it was once a trading post for the export of tin at the turn of last century . This was when the river was the lifeline of the city – its main mode of transportation. The activity at the waterfront has changed over the years with the change of social, economical and physical development of the city. Many waterfront cities throughout the world have gone through similar changes when the mode of transportation changed from water to motor system in their country. A number of cities have made efforts to integrate the cities’ activities with their water body. This research attempts to investigate the activities at the Kuala Lumpur waterfront within the city centre in terms of its level of contextual integration with the urban rivers in the current context. The technique adopted for this research is field observation which include building use survey and time interval observation to investigate the activities in ten demarcated zone along Kuala Lumpur waterfront within the city centre. The research concluded with the findings that all the zones exhibited medium level of contextual integration between the waterfront and the urban river in terms of its building use which depends much on the continuity of activities, their positioning location, accessibility and the provision of space and facilities.
Kelayakan Kulit Salak Dalam Pembuatan Nail Art Sebagai Penunjang Tampilan Rias Fantasi

Field: Arts and Humanities (Social Sciences)

One type of fruit that is liked by people in Southeast Asia, namely Salak. The development of nail art has become one of the supporting appearances for women. So that it becomes a source of ideas in new innovations in the world of nail art. The purpose of this study was to find out how to make nail art by utilizing zalacca peels. In this study using the method, observation, documentation, literature and experimental methods Utilization of zalacca skin in making nail art through three stages, namely preparation of material tools and manufacturing steps. The results of the feasibility test from the five validators, namely the color assessment indicator score 23 is said to be very feasible, the form score 23 is said to be very feasible, the neatness score is 21 is said to be very feasible, and the design gets a score of 23 which is said to be very feasible so that it can be concluded that the product is said to be very feasible. .5% nail art color involved suitable for women's skin, 98.8% beauty nail art color gradations, 96.3% beauty nail art accessories, 98.8% accessories for fantasy makeup, 61.3% nail art accessories in fashion, 86.3% zalacca nail art accessories not excessive, 96.3% accessories on nail art to match, 96.3% nail art able to compete and 98.8% nail art being one of the innovations based on the results of the test 87% of respondents said they liked snake fruit nail art products
Simulation of a Lifting Surface with a Flexible Piezoelectric Actuator in a Rotating Environment

Field: Engineering (Physical Sciences)

In the past years, the consumption of energy produced by wind turbines had an exponential growth. This requirement gave momentum to the development of larger turbines with the goal of producing more energy at the same site, reducing the initial investment, and the operation and maintenance costs. In order to achieve this objective, longer, lighter, maintenance-free blades are required so that smaller loads are transferred to the other, more expensive, wind turbine components.
The resulting larger flexibility, imposes new challenges to the blade and controller designs; henceforth, new concepts are being developed to add more intelligence into these systems. During the last few years, the electronics industry had invested resources into the research and development of practical applications for piezoelectric ceramic materials. The result of this effort was the development of high precision piezoelectric actuators and sensors, which achieve forces and deformations that are compatible with the ones needed for the control of aerodynamic surfaces.
In a former study made by the authors, the aeroservoelastic behavior of a lifting surface with a fixed end and a flexible piezoelectric actuator was analyzed. In that work it was shown that the flexible piezoelectric actuator is an effective tool for vibration control. In the present paper, the analysis of the aeroservoelastic behavior of a lifting surface with a flexible piezoelectric actuator is extended to a non-inertial coordinate system that spins around an inertial one. The actuator is composed of a flexible trailing edge with embedded piezoelectric layers that enables the active control of the local aerodynamic forces. Structurally, both the flexible surface and flap are modeled as continuous beams with fixed-free end conditions. The displacements are described by a series expansion of assumed modes. The system aerodynamics are modeled with an unsteady version of the vortex lattice method (UVLM). High Reynolds number flow is assumed, therefore viscous effects are confined at the boundary layers and the wake shed by the surface. Both surface and wake are idealized as vortex sheets which in turn are discretized with vortex rings. In order to capture the physical aspects from the fluid-structure-control interaction, the aerodynamic and structural numerical models are combined by means of a strong coupling technique. The system equations of motion are integrated iteratively in the time domain. Numerical experiments are performed on a 100m test blade. The results show the feasibility of utilizing this type of actuators in the control of large horizontal axis wind turbines.
Aesthetics, emotions, culture and media

Field: Arts and Humanities (Social Sciences)

The text re-examines, in principle, the status of emotions in the contemporary aesthetic environment. When it comes to our aesthetic environment - we will talk about it from two mutually pervasive points of view: the first position is, at first glance, somewhat broader and concerns the sphere of culture in the aesthetic key, while the second builds on the previous and refers to the so-called. media culture. If today it is possible to separate these two plans of thinking about aesthetic experience (originating either from the field of culture or from the media), and in the context of thinking about emotions that participate in the aesthetic experience related to culture (art), ie media, it seems that with the standardized products of today?s world of culture and media, superficial emotionality, often equal to kitsch dominates our common aesthetic space. And if it is not about the aesthetic phenomena of kitsch, in general, a rational (managerial) approach to culture and media is at work, which almost completely replaces the emotional way of creating an aesthetic experience in our age.
Design and Application of Single Chip Microcomputer in SCR Light Regulation Circuit

Field: Engineering (Physical Sciences)

The aim of this article is to achieve the application of single chip microcomputer in SCR light regulation circuit. Its control part is simplified by analyzing the principle of SCR light regulation circuit. According to control function, the design scheme that let the single chip microcomputer bring about a good control function in SCR light regulation circuit is proposed. The experiment results demonstrate this design is practicable. The light regulation function could be realized by the single chip microcomputer.
Depth Dependence on the Various Scale Lengths in a Quasi-Vitense Model of the Solar Convection Zone

Field: Physics and Astronomy (Physical Sciences)

As has been previously stated (van der Borght) the lengths l 1 , l 2 , l 3 and l 4 are functions of and so a discussion of these lengths is in fact a discussion of the f ’s. For a first approach to a determination of these f ’s, a standard Vitense 2 model of the convection zone—with mixing length l , is used. We assume that l = H . The variables we need are k z , which are the vertical wave number associated with the characteristic eddy, the average vertical velocity, and the average (non-dimensional) temperature fluctuation. These quantities are approximated, using the following relations
Alcoholic Extract of Wrightia tinctoria leaves and Isolates there of afford DNA Protection in Post Irradiated Sprague Dawley Rats

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

: Objective: The current study investigates the potential of alcoholic extract of Wrightia tinctoria leaves and its isolates in repairing the DNA damage induced by gamma radiation. Methodology: The ethanolic extract of Wrightia tinctoria (EEWT) the leaves was subjected to in vitro anti oxidant assay by DPPH radical scavenging and hydrogen peroxide scavenging methods. He EEWT was investigated to the Micronucleus assay, spleen colony assay and comet assay in Sprague Dawley rats wherein DNA damage had already been induced by irradiation. Results: The ethanolic extract of Wrightia tinctoria leaves having good antioxidant activity. In the micronucleus assay, a 2 Gy quantum of whole-body gamma radiation significantly enhanced the levels of micronucleated reticulocytes and this induction was substantially reversed in the extract treatment group. Results of the spleen colony assay pointed to the extract's ability to enhance the recovery of the hematopoietic system, in a dose-dependent manner, following 6 Gy gamma irradiation. The decrease in cellular repair index due to enhanced DNA repair was evident from the comet assay parameters. Moreover, the isolates from ethanolic extract of Wrightia tinctoria, when imperiled to DNA protection by in vitro gamma radiation method in plasmid pBR322 DNA, abetted DNA repair at higher dose. Conclusion: The DNA protection afforded is likely attributable to free radical scavenging properties along with a potential for regenerating the immune system through repair of post irradiated DNA.Key words: Comet assay, DNA damage, Micronucleus assay, Radioprotective, Spleen colony assay, Wrightia tinctoria.
Modulation of Glutathione and Glutathione Dependent Antioxidant Enzymes in Mouse Heart Following Doxorubicin Therapy

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

AbstractThe toxicity of the antineoplastic agent doxorubicin (DOX) has been shown to be moderated by the antioxidant enzyme glutathione peroxidase. It has been reported that acute doses of DOX can cause an inhibition of glutathione peroxidase in cardiac tissue, that may render this tissue especially susceptible to further prooxidant damage. In this study, multiple DOX treatments at a therapeutic dose were assessed for their effect on the antioxidant enzyme status of cardiac and kidney tissue. DOX was administered i.p. (5 mg/kg) once a week for two weeks to male balb/c mice. The activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPOX) and glutathione reductase (GR) were measured 1, 2 and 7 days following the second DOX treatment in both heart and kidney. Levels of reduced glutathione (GSH) were also measured in cardiac tissue at these same times. Cardiac levels of GPOX and GR showed a time-dependent decrease in activity, with 10% and 12% inhibition for GPOX and GR, respectively, at 7 days post second treatment. Cardiac levels of GSH also showed a significant decrease, approximately 15%, at 7 days post second treatment. Cardiac levels of SOD and CAT as well as kidney levels of all four antioxidant enzymes were not affected by DOX treatment. These data suggest that DOX given in a therapeutic regimen, at a therapeutic dose, can cause decreases in cardiac levels of GPOX, GR and GSH that could render the heart especially susceptible to further oxidative challenge.Key Words: Doxorubicinantioxidant enzymesglutathione
Geographies of Brexit and its aftermath

Field: Social Sciences (Social Sciences)

Much has been written since the 2016 Brexit referendum regarding the divides within British society that the vote illustrated – including geographical divides – and their influence on the outcome of the 2017 general election. Focusing on England, this paper explores the extent and significance of those geographical divides at the 2016 referendum, at a variety of spatial scales – concluding that apart from a major difference between parts of inner London and the rest of England these were largely insignificant. Turning to the 2017 general election, analyses show that this return to a predominantly two-party system within England largely involved a replication of the geography of the 2015 general election outcome. A new electoral map of England did not emerge from the divisions that Brexit stimulated: the country is divided along class lines, with London standing out as different from all other regions.
Inleiding: Klimaatbestendigheid als ruimtelijke en maatschappelijke opgave

Field: Social Sciences (Social Sciences)

Climate robustness as a spatial and societal challenge. Building blocks for legitimate adaptation strategies The problem of climate change is high on the various political-administrative agendas, both national and international. At the same time the problem is full of uncertainties and controversies. Adaptation to climate change asks for adjustments in our spatial planning, but can also necessitate changes in the distribution of public and private responsibilities. A crucial question is how the legitimacy of adaptation measures can be organized in a context surrounded with uncertainties, controversies and conflicting interests. In this paper we introduce the central theme of this special issue and the various contributions.
Effect of the Treadmill Gait Training Program Combined with the Thoracic Mobility Exercise on Gait and Balance in Stroke Patients: A Preliminary Randomized, Controlled Study

Field: Health Professions (Health Sciences)

PURPOSE: This study sought to investigate the effects of treadmill gait training combined with a thoracic mobility exercise on gait and balance in patients with stroke. METHODS:In this single-blinded, randomized, controlled, comparative study, a total of 20 patients at a rehabilitation hospital who had suffered a hemiplegic stroke were randomly †Corresponding
Effects of Nd3+ on Calcium-Dependent Processes in Isolated Rat Heart Mitochondria and Frog Heart Muscle

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The inotropic and chronotropic effects of neodymium ions (Nd3+) on the heart muscle of a frog Rana ridibunda and the influence of Nd3+ on respiration, swelling, and potential (∆Ψmito) of Ca2+-loaded rat heart mitochondria (RHM) were studied. It was found that Nd3+ reduced the amplitude and frequency of spontaneous heart contraction (Fmax); Nd3+ also prevented a short-term increase in Ca2+-induced basal respiration of mitochondria and their swelling in salt media, as well as a decrease of ∆Ψmito on the inner mitochondrial membrane (IMM). At the same time, Nd3+ slightly affected mitochondrial respiration in state 3 or in 2,4-dinitrophenol (DNP)-uncoupled state. These effects of Nd3+ may indicate that Nd3+ inhibits the mitochondrial permeability transition pore (MPTP) opening, which is formed in calcium loaded mitochondria. The data obtained are important for a better understanding of the mechanisms of action of rare earth elements on Ca2+-dependent processes in the myocardium of vertebrates.
Velocity of lymph flow in the head and neck lymphatics during food stimulation. Preliminary communication.

Field: Medicine (Health Sciences)

In 12 healthy volunteers the velocity of food stimulated lymph flow in the head and neck lymphatics was studied. The velocity of lymph flow between subsequent lymph nodes had a mean of 0,6 mm/sec with a range of 0,4--1.4 mm/sec thus reaching the range of the velocity of blood in the capillaries.
Photoinduced Charge Separation and Recombination in a Novel Methanofullerene−Triarylamine Dyad Molecule

Field: Chemistry (Physical Sciences)

Intramolecular charge separation (CS) and charge recombination (CR) processes of the dyad molecule linking C60 and N,N-di(6-tert-butylbiphenyl)benzenamine (BBA) were investigated by pico- and nanosecond laser flash photolysis methods. Furthermore, intermolecular electron transfer to a methanofullerene (C61H2) was also investigated; the electron-transfer rate between triplet excited C61H2 and BBA was somewhat slower than that of C60 due to less negative reduction potential of C61H2. As for the BBA−C60 dyad molecule, CS was successfully observed in polar solvents by excitation of C60 moiety with picosecond laser pulse, while only the intersystem crossing was observed in nonpolar solvent. The CS process in the Marcus "normal region" was confirmed. In moderately polar solvent, radical ion pairs recombined within a few nanoseconds to generate the ground state and the triplet excited state of the C60-moiety. On the other hand, in polar solvents, the radical ion pairs decayed by two-steps: Most part decayed within 1 ns, while the radical ions were also observed in the submicrosecond region for a ca. 10% yield of generated BBA•+-C60•-. An equilibrium between CS and triplet states was proposed for the mechanism of long-lived CS state.
Novel computational and drug design strategies for inhibition of monkeypox virus and Babesia microti: molecular docking, molecular dynamic simulation and drug design approach by natural compounds

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background The alarming increase in tick-borne pathogens such as human Babesia microti is an existential threat to global public health. It is a protozoan parasitic infection transmitted by numerous species of the genus Babesia. Second, monkeypox has recently emerged as a public health crisis, and the virus has spread around the world in the post-COVID-19 period with a very rapid transmission rate. These two novel pathogens are a new concern for human health globally and have become a significant obstacle to the development of modern medicine and the economy of the whole world. Currently, there are no approved drugs for the treatment of this disease. So, this research gap encourages us to find a potential inhibitor from a natural source. Methods and materials In this study, a series of natural plant-based biomolecules were subjected to in-depth computational investigation to find the most potent inhibitors targeting major pathogenic proteins responsible for the diseases caused by these two pathogens. Results Among them, most of the selected natural compounds are predicted to bind tightly to the targeted proteins that are crucial for the replication of these novel pathogens. Moreover, all the molecules have outstanding ADMET properties such as high aqueous solubility, a higher human gastrointestinal absorption rate, and a lack of any carcinogenic or hepatotoxic effects; most of them followed Lipinski's rule. Finally, the stability of the compounds was determined by molecular dynamics simulations (MDs) for 100 ns. During MDs, we observed that the mentioned compounds have exceptional stability against selected pathogens. Conclusion These advanced computational strategies reported that 11 lead compounds, including dieckol and amentoflavone, exhibited high potency, excellent drug-like properties, and no toxicity. These compounds demonstrated strong binding affinities to the target enzymes, especially dieckol, which displayed superior stability during molecular dynamics simulations. The MM/PBSA method confirmed the favorable binding energies of amentoflavone and dieckol. However, further in vitro and in vivo studies are necessary to validate their efficacy. Our research highlights the role of Dieckol and Amentoflavone as promising candidates for inhibiting both monkeypox and Babesia microti , demonstrating their multifaceted roles in the control of these pathogens.