jimnoneill/paper-to-field-training huggingface dataset:
Evaluating the effect of vitamin D3 supplementation on DKK-3 serum for third-stage chronic kidney patients

Field: Medicine (Health Sciences)

Vitamin D3 helps to reduce oxidative stress levels, as does Dickkopf-3 (DKK-3) glycoprotein, which is released in the kidney’s tubular membrane during stress and helps promote tubulointerstitial fibrosis. The aim is to investigate how vitamin D supplementation affects serum DKK-3 levels and biochemical indicators of renal function in CKD patients in stage III. The study had inclusion criteria for 180 participants of both sexes, aged between 20 and 35 years. They were divided into 3 groups: 60 healthy participants as control, 60 CKD patients in stage III (without vitamin D3 supplements), and 60 others (with three months of 5,000 IU of weekly vitamin D3 supplements). DKK-3 levels in serum, vitamin D3, and parathyroid hormone were examined, and kidney function was tested. Findings indicated a significant increase in levels of DKK-3 serum for patients in the 2 and 3 groups with CKD compared with control. Additionally, outcomes revealed significantly lower DKK-3 (41%) in the third group of patients who took vitamin D compared to the second group (120%) without vitamin D supplements. There was also an improvement in several kidney functions for the third group, and the relationships revealed a significant inverse association between the levels of vitamin D3 and serum DKK3. Also, there is a significant inverse association with urea and creatinine levels; additionally, there is a significant positive association with glomerular filtration rate and calcium. In conclusion, DKK-3 may be a potential biomarker for the development of CKD. Furthermore, vitamin D administration improved kidney function and DKK-3 levels in individuals with stage III CKD. As a result, vitamin D can assist in reducing the development of chronic kidney disease.
[Exercise radionuclide ventriculography in evaluating successful percutaneous transluminal coronary angioplasty (PTCA)].

Field: Medicine (Health Sciences)

To evaluate late success of PTCA in 29 patients with coronary artery disease, exercise radionuclide ventriculography was performed. Twenty-nine patients were classified into two groups according to the presence of restenosis (Group N: 19 patients without restenosis, Group R: 10 patients with restenosis). LVEF improved significantly in Group N, and the sensitivity, specificity and overall accuracy for detecting restenosis were 100%, 68% and 79%, respectively. Regional wall motion abnormality during exercise did not worsened in Group N, and the sensitivity, specificity and overall accuracy for detecting restenosis were 89%, 96%, and 94%, respectively. The left ventricular end-systolic volume during exercise increased in group R but decreased in Group N. The exercise response of the ratio of systolic blood pressure to end-systolic volume in Group N was significantly larger than that of Group R, and was considered to be useful parameter for detecting restenosis.
Problems of Sustainable Functioning of Urban Transport Systems

Field: Social Sciences (Social Sciences)

The main problems of transport systems in big cities have been analyzed, the problems of transport functioning, their division into groups have been systematized, the highway structure of the constituent entities of Russian Federation has been analyzed, the issues of the development and maintenance of the urban highways have been considered, the problems of existing urban areas, as well as the problems of transport systems designing have been considered, and the main directions of the current situation solution have been suggested.
Innovative Teaching Reform and Practice in Strategic Management of Enterprises Based on the Context of Enterprise Diversification

Field: Business, Management and Accounting (Social Sciences)

Strategic management of Enterprise is a comprehensive course, the teaching process integrated financial management, marketing human resources management and etc. Most of the enterprises will adopt diversified management as their strategic target to make profits by the impact of globalization. How to make students participate in learning process ,then use the management methods in real business management situation, try to identify four steps in strategic management by practicing in the enterprises, establish a strategic partnership platform for teachers-enterprises-students, make a effectively improvement though learning and teaching for all of the three in the end.
Pharmacognostic standardization of Homoeopathic drug: Juniperus virginiana L.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background: Juniperus virginiana L., commonly known as 'red cedar' in English is a well-known evergreen tree belonging to the family Cupressaceae. The leaves and young aerial shoots are used for preparation of medicine in Homoeopathy. Objective: Standardization is the quintessential aspect which ensures purity and quality of drugs. Hence, the pharmacognostic and physico-chemical studies are carried out to facilitate the use of authentic and correct species of raw drug plant material with established parametric standards for manufacturing the drug. Materials and Methods: Pharmacognostic studies on leaves and young aerial parts of authentic samples of J. virginiana L. have been carried out; physico-chemical parameters of raw drug viz., extractive values, ash values, formulation, besides weight per mL, total solids, alcohol content along with High Performance Thin Layer Chromatography (HPTLC) and ultraviolet visible studies have been worked out for mother tincture. Results: The leaves are needles, narrow and sharp at tips; stems are round with greyish white to brown bark possessing small lenticels and covered by imbricate leaves. Epidermal cells in the surface have polygonal linear sides with pitted walls containing crystals and starch. Stomata exclusively occur on the adaxial surface in linear rows. Hypodermis of leaf in T.S. is marked with 1-2 layered lignified sclerenchyma. 2-4 secretory canals are present with one conspicuously beneath midvein bundle. The young terminal axis is sheathed by two closely surrounding leaves while the mature stem possess four leaf bases attached. Vascular tissue of stem possesses predominant xylem surrounded by phloem containing sphaeraphides, prismatic crystals and starch grains. Uniseriate rays occur in the xylem. Mature stem possess shrivelled cork, followed by the cortex. Physicochemical properties and HPTLC values of the drug are standardized and presented. Conclusion: The powder microscopic features and organoleptic characters along with anatomical and physicochemical studies are diagnostic to establish the standards for the drug.
Development of a management protocol for internal carotid artery injury during endoscopic surgery: A modified Delphi method and single-center multidisciplinary working group

Field: Medicine (Health Sciences)

Background Intra-operative internal carotid artery (ICA) injury during transnasal endoscopic surgery is a potentially catastrophic event. Such an injury is life-threatening in the immediate setting, with a reported peri-operative mortality rate of 10%. Nasal packing, muscle patches, direct vessel closure, and endovascular techniques have been described as useful strategies for managing ICA bleeds. The objective of this study was to develop a formalized management protocol for intra-operative ICA injury through engagement with a multi-disciplinary panel. Methods A modified Delphi method including literature review, iterative rounds of stakeholder feedback, and expert panel discussions was used to develop a management protocol for ICA injury during transnasal endoscopic surgery. The 10-person multi-disciplinary panel included otolaryngologists, neurosurgeons, interventional neuroradiologists, anesthesiologists, and operating room nursing staff. Results After three rounds of stakeholder engagement with the expert panel, consensus was reached on important elements to include within the protocol. The protocol was divided in three categories: Alert, Control, and Transfer. ‘Alert’ focusses on early communication with anesthesia and nursing staff. ‘Control’ focusses on techniques to expose the injury and obtain hemostasis or adequate tamponade. Lastly, ‘Transfer’ describes the process of contacting neuro-interventional radiology and safely transferring the patient. A one-page handout of the protocol was developed for placement in operating theatres. Conclusion Due to the life-threatening nature of ICA injury, it is imperative that endoscopic sinus and skull base surgeons are prepared to manage this complication. Using a modified Delphi method with a multidisciplinary expert panel, a protocol for management of intra-operative ICA injury was developed. Graphical Abstract
Profiling techniques for communication in fine‐grained parallel languages

Field: Computer Science (Physical Sciences)

Fine tuning the performance of large parallel programs is a very difficult task. A profiling tool can provide detailed insight into the utilization and communication of the different processors, which helps identify performance bottlenecks. In this paper we present two profiling techniques for the fine-grained parallel programming language Split-C, which provides a simple global address space memory model. One profiler provides a detailed analysis of a program's execution. The other profiler collects cumulative information. As our experience shows, it is quite challenging to profile programs that make use of efficient, low-overhead communication. We incorporated techniques which minimize profiling effects on the running program, and quantified the profiling overhead. We present several Split-C applications showing that the profiler is useful in determining performance bottlenecks. Copyright © 1999 John Wiley & Sons, Ltd.
Developing a Prototype System for Integrating Pharmacogenomics Findings into Clinical Practice

Field: Health Professions (Health Sciences)

Findings from pharmacogenomics (PGx) studies have the potential to be applied to individualize drug therapy to improve efficacy and reduce adverse drug events. Researchers have identified factors influencing uptake of genomics in medicine, but little is known about the specific technical barriers to incorporating PGx into existing clinical frameworks. We present the design and development of a prototype PGx clinical decision support (CDS) system that builds on existing clinical infrastructure and incorporates semi-active and active CDS. Informing this work, we updated previous evaluations of PGx knowledge characteristics, and of how the CDS capabilities of three local clinical systems align with data and functional requirements for PGx CDS. We summarize characteristics of PGx knowledge and technical needs for implementing PGx CDS within existing clinical frameworks. PGx decision support rules derived from FDA drug labels primarily involve drug metabolizing genes, vary in maturity, and the majority support the post-analytic phase of genetic testing. Computerized provider order entry capabilities are key functional requirements for PGx CDS and were best supported by one of the three systems we evaluated. We identified two technical needs when building on this system, the need for (1) new or existing standards for data exchange to connect clinical data to PGx knowledge, and (2) a method for implementing semi-active CDS. Our analyses enhance our understanding of principles for designing and implementing CDS for drug therapy individualization and our current understanding of PGx characteristics in a clinical context. Characteristics of PGx knowledge and capabilities of current clinical systems can help govern decisions about CDS implementation, and can help guide decisions made by groups that develop and maintain knowledge resources such that delivery of content for clinical care is supported.
Fracture of the penis--report of seven cases.

Field: Medicine (Health Sciences)

Fracture of the penis is an uncommon emergency consisting of rupture of the tunica albuginea of the corpus cavernosum resulting from blunt trauma over an erect penis. Prompt diagnosis and early surgical repair are essential to ensure a successful outcome with minimal complications. Delay may result in devastating physical and psychological disabilities that are potentially avoidable. Here in this article, 7 cases of fracture penis are being reported, who had been managed successfully by surgery in 6 cases and one case treated conservatively as he refused surgery.
FEASIBILITY OF FALLS PREVENTION PROGRAMS IMPLEMENTATION BASED ON ACADEMIC-COMMUNITY PARTNERSHIPS

Field: Health Professions (Health Sciences)

Abstract The Northern Virginia (NoVa) region is diverse in age, race, ethnicity, economic status, health status, culture, and language. Based on state data, it is estimated that 28.7% of the 75,000 older adults in NoVa will experience at least one fall annually. Since 2014, the Administration for Community Living (ACL) has sponsored implementation of evidence-based fall prevention programs (EBFPPs). The aims of this study are to 1) describe the EBFPP participants and delivery sites and 2) report initial effectiveness. Marymount University (MU) received two cooperative agreement grants (2016, 2018) from the ACL to implement in NoVa three EBFPPs: 1) Stay Active and Independent for Life (SAIL), 2) A Matter of Balance (MOB), and 3) Otago Exercise Program (OEP). The Northern Virginia Falls Prevention Alliance was formed and a Regional Training Office was built. The data source is the ACL national falls database. From 2016–2022, over 5,000 older adults were reached, over 400 EBFPP leaders were trained, and programs were delivered at 60 sites. Data analysis indicates that falls decreased from 20% to 15%. Those participating in MOB showed the greatest decline in falls (from 34% to 14%). Fall injuries declined from 11% to 7% and ED visits decreased from 3% to 1%. Preliminary analysis indicates beneficial impact: this academic-community partnership has reached people at low risk of falling (SAIL), and had an impactful decline in falls for individuals at moderate to high risk (MOB). Future research will investigate program outcome differences based on other demographics and delivery models.
A Photovoltaic Power System for the Holman Guest House, Fort Huachuca, Arizona.

Field: Energy (Physical Sciences)

This report documents the specification, design, installation, and acceptance of a 5-kilowatt-peak, grid-connected, photovoltaic power system for the Holman Guest House at Fort Huachuca, AZ. This system, designed and installed at a cost of $112,000, was funded by the Department of Energy's Federal Photovoltaic Utilization Program. The system operates in parallel with the local utility grid without battery storage. The photovoltaic (PV) array, consisting of 196 roof-mounted panels, generates direct current at about 210 V. The array output is converted to alternating current by a three-phase, line-commutated inverter developed specifically for the application. The inverter output, estimated at about 11,000 kWh per year, meets a portion of the Guest House's electrical demands. Tests performed at the time of the system's acceptance have demonstrated its ability to deliver the rated power output. The U.S. Army Construction Engineering Research Laboratory is now conducting a 1-year evaluation to determine the systems's long-term performance and to learn more about the feasibility of applying grid-connected PV systems to fixed military facilities. (Author)
Mid-flight Forecasting for CPA Lines in Online Advertising

Field: Computer Science (Physical Sciences)

For Verizon MediaDemand Side Platform(DSP), forecasting of ad campaign performance not only feeds key information to the optimization server to allow the system to operate on a high-performance mode, but also produces actionable insights to the advertisers. In this paper, the forecasting problem for CPA lines in the middle of the flight is investigated by taking the bidding mechanism into account. The proposed methodology generates relationships between various key performance metrics and optimization signals. It can also be used to estimate the sensitivity of ad campaign performance metrics to the adjustments of optimization signal, which is important to the design of a campaign management system. The relationship between advertiser spends and effective Cost Per Action(eCPA) is also characterized, which serves as a guidance for mid-flight line adjustment to the advertisers. Several practical issues in implementation, such as downsampling of the dataset, are also discussed in the paper. At last, the forecasting results are validated against actual deliveries and demonstrates promising accuracy.
International Tourism, Digital Infrastructure, and CO2 Emissions: Fresh Evidence From Panel Quantile Regression Approach

Field: Environmental Science (Physical Sciences)

Abstract

The main motivation behind this study is the importance of the tourism sector and digitalization in the economic development of a country and their potential effects on the country's environmental quality. For empirical analysis, the study applies FMOLS, DOLS, and quantile regression techniques for Asian economies. The findings of the study confirmed that tourism and digitalization improve environmental quality in FMOLS and DOLS models. In the basic quantile regression model, the estimates attached to tourism arrival are positive 5th quantile to 40th quantile and then turn negative from 60th quantile and onwards. Likewise, the estimates attached to tourism receipts in the robust quantile regression model are positive from quantile 5th to quantile 20 and negative and increasing from quantile 30 and onwards. Conversely, the estimates of digital infrastructure are insignificant in the basic quantile model at all quantiles except 95th. However, the estimated coefficients of digital infrastructure in the robust model are negative and rising from 40th quantile to 70th quantile and negative and declining from 80th quantile to 95th quantile. In general, we can say that as the tourism and digital sectors grow, the CO2 emissions decline.
Label-free imaging of fatty acid content within yeast samples

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Fungi have been found to be an underlying cause of 70% of all plant and animal extinctions caused by infectious diseases. Fungal infections are a growing problem affecting global health, food production and ecosystems. Lipid metabolism is a promising target for antifungal drugs and since effective treatment of fungal infections requires a better understanding of the effects of antifungal agents at the cellular level, new techniques are needed to investigate this problem. Recent advances in nonlinear microscopy allow chemically-specific contrast to be obtained non-invasively from intrinsic chemical bonds within live samples using advanced spectroscopy techniques probing Raman-active resonances. We present preliminary data using Stimulated Raman Scattering (SRS) microscopy as a means to visualise lipid droplets within individual living fungi by probing Raman resonances of the CH stretching region between 2825cm-1 and 3030cm-1. © 2013 Copyright SPIE.
Study on Wheat Peptides on Immune Modulating and Antioxidant Effect

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The aim was to study immune modulating and antioxidant effects of immune active component,an Alcalase hydrolyzate from wheat isolated proteins.In vivo study showed that wheat bioactive peptides could increase the number of antibody-producing cells and serum hemolysin,significantly stimulate multiplication of mice spleen lymphocytes and promote the phagocytic function of macrophages;then wheat bioactive peptides could increase serum DPPH and hydroxyl radical scavenging ability,promote the T-AOC and the activities of SOD and CAT,decrease the contents of MDA.And immune modulating effect of the hydrolyzate was correlated with its effect on host antioxidant system.
Gene Expression Wordsearch

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

This puzzle contains 28 names, abbreviations, and acronyms that describe the regulation of gene expression in a 14-by-14-letter matrix. A descriptive narrative with underlined spaces to be filled gives clues to the terms students need to find. When all are found, the 29 letters remaining in the matrix complete a sentence describing regulation in E. coli. This wordsearch puzzle is suitable for any course that introduces the control of gene expression.
Drying kinetics of jatropha seeds

Field: Agricultural and Biological Sciences (Life Sciences)

Given the necessity of developing jatropha cultivation equipment, this work adjusted different mathematical models to experimental data obtained from the drying of jatropha seeds submitted to different drying conditions and selected the best model to describe the drying process. The experiment was carried out at the Federal Institute of Goiás - Rio Verde Campus. Seeds with initial moisture content of approximately 0.50 (kg water/kg dry matter) were dried in a forced air-ventilated oven, at temperatures of 45, 60, 75, 90 and 105°C to moisture content of 0.10 ± 0.005 (kg water/kg dry matter). The experimental data were adjusted to 11 mathematical models to represent the drying process of agricultural products. The models were compared using the coefficient of determination, chi-square test, relative mean error, estimated mean error and residual distribution. It was found that the increase in the air temperature caused a reduction in the drying time of seeds. The models Midilli and Two Terms were suitable to represent the drying process of Jatropha seeds and between them the use of the Midili model is recommended due to its greater simplicity.