jimnoneill/paper-to-field-training huggingface dataset:
Divine Sophia : A Review of the Spiritual and Psychological Role of the Sacred Feminine in Corbin, Ibn'Arabi, Jung, and Alchemical Symbolism

Field: Arts and Humanities (Social Sciences)

This literature review examines core concepts of the psychospiritual function of \nthe Divine Sophia in humans' experience of the divine. It looks at the philosophy of Sufi \nMaster Ibn' Arabi, mostly through the translations and interpretations of French scholar \nHenry Corbin. I also review the work of Jung and Jungian scholars on the archetype of \nthe higher anima or Sophia as well as some alchemical symbolism. This review shows \nhow Corbin's analysis oflbn' Arabi's spiritual philosophy relates to the field of depth \npsychology. Jung, Corbin, and their followers postulate that spirituality is an intrinsic part \nofhuman's psyche and search for meaning. They thus find great value in masters like \nIbn' Arabi who reported the experience of gnosis, a direct encounter with the divine \nthrough Imagination. \nOne aspect of this path to spiritual awareness is to reconnect with the divine \nfeminine and the ancient wisdom of the world-Sophia-in order to rebalance the \nmasculine and feminine aspects oflife. The Feminine, Fatima-Sophia (Corbin, \n1990/l 998b) appears as the preeminent symbol of the Self, and to have knowledge of \noneself is to have knowledge of God. Sophia, as the Feminine-Creator or the soul of the \nworld, presents herself and the Divine in nature, animals, and the arts, enabling each of \nthese to serve as a bridge to the Divine. \nThe religion ofthefedeli d'amore, or faithful in love, is the religion in which the \nfedeli d'amore are reborn in, or give birth to, their true, angelic self (Corbin, \n1958/1998a). The literature review focuses on the central place that Sophia holds in the \npsychospiritual experience of the divine, and therefore in humans' ability to know their \ntrue selves, that is, their divine nature. \nSeveral core concepts are examined, beginning with the angelic function of a \nbeing as the true self, that is to say the pure divine essence of a being. The second core \nconcept is God's Names or divine attributes, which are the ways in which God describes \nHimself to humans through themselves. One can know God's attributes only by one's \nknowledge of oneself, and one can discover and experience the Names in one's own \nmode of being. Therefore, by giving substance to and manifesting a Name one becomes a \ntheophany, a visible manifestation of God. For this manifestation to be possible and \nrecognized as divine in essence, one must feel sympathy for the Divine. One must put \noneself in the service of mystical love and have an ardent desire to be at the service of the Divine. \nImagination is a core concept of the religion of the Jedele d'amore. Imagination, \nthe ability to attain a state of mind that allows for an encounter with the Divine, is \npossible only through a sympathetic relationship to the Divine. It involves seeing with the \nheart, where the heart is understood as a spiritual function, "an organ of subtle \nphysiology" (Corbin, 1958/1998a, p. 221).
Movement of the Gravity of Carbon Emissions Per Capita and Analysis of Causes

Field: Environmental Science (Physical Sciences)

In order to make the regional differences caused by carbon emissions per capita clear,the concept of gravity is introduced.The locations as well as the changes of gravity from 1995 to 2005 are calculated and the characteristics of the gravity's movements are concluded.Based on that,two methods are used to analyze the causes of the gravity's movements.First by the direct analysis in which perpendicular bisector of gravity line is employed.Then the decomposition model is utilized to analyze the contribution rates of each factor to each region.The results show that the contribution rates of influencing factors vary greatly in different regions.Generally speaking,the main factors that have effects on the amount of carbon emissions per capita are economic development and energy efficiency.Finally,some suggestions are proposed such as to popularize advanced technology to reduce regional differences in energy efficiency and propel the adjustment of energy structure to boost the inhibiting effect that energy structure has on carbon emissions per capita.
THE CHALCID SEED WASP, MEGASTIGMUS NIGROVARIEGATUS HYMENOPTERA: TORYMIDAE, ON ROSA RUGOSA THUNB. IN NOVA SCOTIA

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Two naturalized populations and two planted populations of Rosa rugosa Thunb. were studied with respect to chalcid seed wasp infestation. Megastigmus nigrovariegatus Ashmead was found in hips from planted R . rugosa in Halifax and Dartmouth, Nova Scotia, but not from bushes at naturalized sites. The percentage of infested hips at the Halifax and Dartmouth locations was 26 and 31%, respectively. The percentage of infested achenes within a single hip varied widely from 3 to 79% at the Halifax site and 7 to 60% at the Dartmouth site.Adult emergence was over 75% successful when achenes were over 2 mm in diameter but less than 15% for smaller achenes. The exit hole on the achene faced the outer wall of the hip. Adults emerged later in Nova Scotia than in the United States and between 59 and 72% were female. More than one adult wasp was observed ovipositing on a single hip.
Supplementary Table S4 from Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>Supplemenary Table S4 shows the differential expressed genes in 25nM Selinexorvs DMSO treatment at 24hr in OCI-AML3-NPM1c-degron2 cells.</p>
Acupuncture in the treatment of stable chronic obstructive pulmonary disease: A systematic review of randomised controlled trials

Field: Medicine (Health Sciences)

Objective: To systematically evaluate the clinical efficacy and safety of acupuncture in the treatment of chronic obstructive pulmonary disease (COPD). Methods: Randomised controlled trials (RCTs) of acupuncture and/or transcutaneous electrical nerve stimulation over acupoints (acu-TENS) in the treatment of the stable COPD were searched in PubMed, Embase, The Cochrane Library, WanFang Data, VIP, CNKI and CBM databases from the respective inception to January 2019. Literature screening and data extraction were independently performed by two researchers and methodological quality was assessed using the Cochrane Collaboration Risk of Bias Tool. Outcome measures included treatment efficiency, quality of life, lung function, activity tolerance and adverse events were evaluated. Results: Eleven RCTs involving 709 patients were included. The results showed that the treatments of COPD, acupuncture and/or acu-TENS could improve the treatment efficiency compared with the control group [RR = 1.11, 95%CI (1.02 to 1.21), P = 0.02], improve the quality of life [MD = −3.66, 95%CI (−5.56 to −1.76), P = 0.0002], increased percentage of forced expiratory volume in 1 s (FEV1%) [MD = 8.75, 95%CI (0.98 to 16.51), P = 0.03], increased predicted forced vital capacity (FVC%) value [MD = 7.93, 95%CI (1.83 to 14.03), P = 0.01], increased FVC(L) [MD = 0.16, 95%CI (0.01 to 0.30), P = 0.04] and decreased Borg score [MD = -3.00, 95%CI (-3.99 to −2.01), P = 0.00001]. Only 3 cases reported mild contusion and pain. Conclusions: Our systematic review shows that the combination of acupuncture with medications and/or rehabilitation exercise may increase efficacy in stable COPD treatment by alleviating the clinical symptoms and improving the quality of life.
Sizing ocean giants: patterns of intraspecific size variation in marine megafauna

Field: Agricultural and Biological Sciences (Life Sciences)

What are the greatest sizes that the largest marine megafauna obtain? This is a simple question with a difficult and complex answer. Many of the largest-sized species occur in the world’s oceans. For many of these, rarity, remoteness, and quite simply the logistics of measuring these giants has made obtaining accurate size measurements difficult. Inaccurate reports of maximum sizes run rampant through the scientific literature and popular media. Moreover, how intraspecific variation in the body sizes of these animals relates to sex, population structure, the environment, and interactions with humans remains underappreciated. Here, we review and analyze body size for 25 ocean giants ranging across the animal kingdom. For each taxon we document body size for the largest known marine species of several clades. We also analyze intraspecific variation and identify the largest known individuals for each species. Where data allows, we analyze spatial and temporal intraspecific size variation. We also provide allometric scaling equations between different size measurements as resources to other researchers. In some cases, the lack of data prevents us from fully examining these topics and instead we specifically highlight these deficiencies and the barriers that exist for data collection. Overall, we found considerable variability in intraspecific size distributions from strongly left- to strongly right-skewed. We provide several allometric equations that allow for estimation of total lengths and weights from more easily obtained measurements. In several cases, we also quantify considerable geographic variation and decreases in size likely attributed to humans.
Consumer Preference Analysis for Websites Using e-TailQ and AHP

Field: Business, Management and Accounting (Social Sciences)

In today’s scenario when the world is going online, websites are the first point of contact for the consumers. It has become a necessity to have a website nowadays to be effective and successful in this internet infiltrated world. A well-thought-out web design plan generates an extraordinary customer experience. In this paper we study the various scales and model given by researchers at different point of time related to website service quality. Here we have taken into consideration the e-Tail Quality (e-TailQ) scale for our study purpose. The model has five factors of online retailing customer experience: website layout, website information, reliability/customer service, fulfilment and security/privacy. These factors were then tested based on the Analytic Hierarchy Process (AHP) model which is based on an exponential scale to calculate each criterion’s relative weight. The research is an endeavor to move further in measuring customer preference towards the service qualities offered by the websites and developing a more focused approach.
Effect of Ulinastatin Combined with Somatostatin on Inflammatory Markers, Hemodynamics and Immune Cells in the Treatment of Severe Pancreatitis.

Field: Medicine (Health Sciences)

The findings of this study hold substantial clinical implications, potentially influencing treatment protocols and patient management strategies for severe pancreatitis. The integration of ulinastatin combined with somatostatin into standard care protocols could significantly improve treatment outcomes and patient prognosis.
Expression of Toll-like receptors in the intestinal mucosa of patients with inflammatory bowel disease

Field: Medicine (Health Sciences)

Inflammatory bowel disease (IBD) consists of Crohn's disease, which involves not only the large intestine but also the small intestine, and ulcerative colitis, which only involves the large intestine. The dysregulation of innate and adaptive intestinal immune responses to bacterial microbiota is believed to be highly involved in the pathogenesis of IBD. Toll-like receptors (TLRs) play a key role in microbial recognition in innate immunity and control the adaptive immune responses. Among the TLRs, TLR2 recognizes bacterial lipoprotein and peptidoglycan, whereas TLR4 and its coreceptor, CD14, recognize lipopolysaccharide. The expression levels of TLR2 or TLR4 have been shown to be limited in the intestine of healthy volunteers, suggesting a minimalization of the recognition of microbiota in the intestinal lumen. The paper under evaluation highlighted the expression levels of TLR2, TLR4 and CD14 in the terminal ileum, cecum and rectum of IBD patients (19 Crohn's disease and 20 ulcerative colitis patients) and of 20 healthy volunteers. The authors suggested that the dysregulation of TLR2, TLR4 and CD14 expression in different parts of the intestinal mucosa might, therefore, play a crucial role in the pathogenesis of IBD.
doi:10.1155/2010/467136 Research Article An Open-Label, Noncomparative, Multicenter Study to Evaluate Efficacy and Safety of NASHA/Dx Gel as a Bulking Agent for the Treatment of Fecal Incontinence

Field: Medicine (Health Sciences)

Copyright © 2010 Giuseppe Dodi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fecal incontinence (FI) is the involuntary loss of rectal contents through the anal canal. Reports of its prevalence vary from 1–21%. Studies, have demonstrated a positive effect on FI symptoms with injectable bulking agents. This study evaluated the safety and efficacy of NASHA/Dx gel in the treatment of FI. One hundred fifteen eligible patients suffering from FI received 4 injections of 1mLNASHA/Dxgel.Primaryefficacy was based on data from 86 patients that completed the study. This study demonstrated a ≥50 % reduction from baseline in the number of FI episodes in 57.1 % of patients at 6 months, and 64.0 % at 12 months. Significant improvements (P &lt;.001) were also noted in total number of both solid and loose FI episodes, FI free days, CCFIS, and FIQL scores in all 4 domains. The majority of the treatment related AEs (94.9%) were mild or moderate intensity, and (98.7%) of AEs
Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Cancer genome sequencing studies have identified driver genes for a variety of different cancers and helped to understand the genetic landscape of human cancer. It is still challenging, however, to identify cancer driver genes with confidence simply from genetic data alone. In vivo forward genetic screens using Sleeping Beauty ( SB ) transposon mutagenesis provides another powerful genetic tool for identifying candidate cancer driver genes in wild‐type and sensitized mouse tumors. By comparing cancer driver genes identified in human and mouse tumors, cancer driver genes can be identified with additional confidence based upon comparative oncogenomics. This review describes how SB mutagenesis works in mice and focuses on studies that have identified cancer driver genes in the mouse gastrointestinal tract.
Therapeutic Treatment for Benign Prostatic Hyperplasia

Field: Medicine (Health Sciences)

1. Medical Management - Watchful Waiting 2. The Placebo Effect in the Treatment of Benign Prostatic Hyperplasia 3. Dutasteride in the Treatment of the BPH Patient 4. Finasteride in the Treatment of Benign Prostatic Hyperplasia 5. Combination Therapy in the Treatment of BPH 6. The Differential Effects of Adrenoceptor Antagonists on Prostate Tissue Growth 7. Terazosin in the Treatment of the Lower Urinary Tract 8. Doxazosin in the Treatment of Benign Prostatic Hyperplasia 9. Alfuzosin 10. Tamsulosin 11. Phytotherapeutic Agents in the Treatment of LUTS and BPH 12. Uroselectivity Revisited
Acylal hydrolysis. The pH-independent breakdown of 7-oxo-6,8-dioxabicyclo[3.2.1]octane

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcylal hydrolysis. The pH-independent breakdown of 7-oxo-6,8-dioxabicyclo[3.2.1]octaneThomas H. Fife and Ramesh BembiCite this: J. Org. Chem. 1992, 57, 4, 1295–1298Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://doi.org/10.1021/jo00030a045RIGHTS & PERMISSIONSArticle Views129Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (502 KB) Get e-Alerts Get e-Alerts
Scoparone attenuates PD-L1 expression in human breast cancer cells by MKP-3 upregulation

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Breast cancer is a frequently occurring malignant tumor that is one of the leading causes of cancer-related deaths in women worldwide. Monoclonal antibodies that block programed cell death 1 (PD-1)/programed cell death ligand 1 (PD-L1) - a typical immune checkpoint - are currently the recommended standard therapies for many advanced and metastatic tumors such as triple-negative breast cancer. However, some patients develop drug resistance, leading to unfavorable treatment outcomes. Therefore, other approaches are required for anticancer treatments, such as downregulation of PD-L1 expression and promotion of degradation of PD-L1. Scoparone (SCO) is a bioactive compound isolated from Artemisia capillaris that exhibits antitumor activity. However, the effect of SCO on PD-L1 expression in cancer has not been confirmed yet. This study aimed to evaluate the role of SCO in PD-L1 expression in breast cancer cells in vitro. Our results show that SCO downregulated PD-L1 expression in a dose-dependent manner, via AKT inhibition. Interestingly, SCO treatment did not alter PTEN expression, but increased the expression of mitogen-activated protein kinase phosphatase-3 (MKP-3). In addition, the SCO-induced decrease in PD-L1 expression was reversed by siRNA-mediated MKP-3 knockdown. Collectively, these findings suggest that SCO inhibited the expression of PD-L1 in breast cancer cells by upregulating MKP-3 expression. Therefore, SCO may serve as an innovative combinatorial agent for cancer immunotherapy.
SH2865810.08FU

Field: Agricultural and Biological Sciences (Life Sciences)

UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
Immunotherapy-based neoadjuvant therapy followed by concurrent chemoradiotherapy in locally advanced and advanced cervical cancer: A real-world study.

Field: Medicine (Health Sciences)

e17509 Background: Locally advanced and advanced cervical cancer (CC), characterized by extensive local invasion and potential distant metastasis, present substantial clinical challenges. Although concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced CC, a considerable proportion (23%-34%) of treated pts experienced recurrence or subsequent metastasis. Recently, neoadjuvant therapy (NAT) has been proposed to increase the radiosensitivity and decreases the fraction of hypoxic cells. Particularly, immunotherapy (IO)-based NAT has shown high activity in treating CC. Moreover, IO plus CRT has shown promise in enhancing both local control and systemic response. Hence, we analyzed the efficacy and safety of IO-based NAT followed by CCRT for locally advanced and advanced CC in a real-world setting. Methods: This study retrospectively analyzed data from pts with locally advanced and advanced CC who underwent IO-based NAT followed by CCRT at Shengjing Hospital of China Medical University from January 2022 to January 2024. Outcome measures included complete response (CR), partial response (PR), objective response rate (ORR), progression free survival (PFS), and safety. Tumor responses after neoadjuvant or CCRT therapy were evaluated using RECIST v1.1 and PFS was analyzed with the Kaplan-Meir method. Safety was assessed by adverse events (AEs) referring to CTCAEs v 5.0. Results: A total of 20 pts (median age 57 years, range, 39-72) were included in this analysis, with 15% at stage IIIB, 60% at IIIC, 10% at IVA, and 15% at IVB. Eight (40%) pts received 1 cycle of neoadjuvant IO, 8 (40%) received 1-4 cycles of neoadjuvant IO + chemotherapy, and 4 (20%) received 2 cycles of neoadjuvant IO + bevacizumab (Bev) + chemotherapy. After NAT, all 20 pts received CCRT. In the overall population, ORR after NAT was 55% (11/20), with 5% CR and 50% PR. Regarding different IO-based NAT regimens, objective responses were achieved in 1 of 8 (12.5%) pts receiving neoadjuvant IO, 6 of 8 (75%) pts receiving neoadjuvant IO + chemotherapy, and 4 of 4 (100%) pts receiving neoadjuvant IO + Bev + chemotherapy. After CCRT, 6 (30%) pts had a CR and 7 (35%) pts had a PR, resulting in an ORR of 65.0%. At a median follow-up of 14.9 months, the median PFS was not reached, with a 12-month and 24-month PFS rates of 68% and 56%, respectively. The most common treatment-related AEs during NAT were white blood cell count decreased (50%) and neutrophil count decreased. Conclusions: IO-based NAT followed by CCRT were effective and well-tolerated for pts with locally advanced and advanced CC. This treatment modalities may provide a potential therapeutic strategy for locally advanced and advanced CC.