jimnoneill/paper-to-field-training huggingface dataset:
MyGene2 automated match report: UNC13D

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for UNC13D.
Omental Transplantation against NMO and MS: A Method to Decrease or Prevent Relapses

Field: Medicine (Health Sciences)

To date, we do not know the etiological agents of Neuromyelitis Optica (NMO) and Multiple Sclerosis (MS) that trigger the production of specific antibodies (autoimmune reaction) in the bloodstream, against aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) antigens located in the astrocytes and oligodendrocytes, respectively. Agents that also cause immunological abnormalities, which damage the intima of the arteries and the blood brain barrier (BBB). Thus, AQP4 and MOG antibodies, as well as cytokines and activated leukocytes cross the injured BBB to cause inflammation, demyelination and degeneration. The clinical course in both diseases is generally characterized by periods of relapses and remissions. For these reasons, based on previous neurosurgical experiences, I believe that an omental transplantation on the optic chiasma and anteromedial temporal lobes can decrease or prevent relapses. Because the omentum produces revascularization and provides stem cells to the hypothalamus and surrounding zones.
FOREARM LENGTHENING IN CHILDREN

Field: Medicine (Health Sciences)

Forearm lengthening in children is controversial. Paley (1990) and Peterson (1994) advocate aggressive treatment of the deformity for cosmetic and functional reasons. Scoenecker (1997) has shown that mature patients are comfortable with their appearance and functional deficit. We reviewed 8 forearm lengthenings performed in 8 children in the 14 year period from 1991 to 2004. Five patients had ulnar shortening (osteochondromata = 4, growth arrest due to trauma = 1). Of the three patients with radial shortening, one was due to a congenital short radius and two following growth arrest (post trauma and meningococcal septicemia). The shortening resulted in a cosmetically unacceptable ulnar or radial tilt with absent radial or ulnar deviation of the wrist and decreased supination and/or pronation. One patient with a proximal ulnar osteochondroma had a dislocation of the radial head with cubitus varus. Excision of the osteochondroma was done 6 months prior to lengthening. Lengthening was accomplished with two Ilizarov rings and a distal corticotomy for radial and proximal for ulnar shortening. Reduction of the dislocated radial head was achieved with an olive wire. Associated procedures were: hemiepiphyseal stapling of the distal radius for an increased radial articular angle in 3 patients with osteochondroma, and corrective osteotomy of the distal radius in 1 patient with growth arrest. The average lengthening obtained was 23 mm (range 13–40 mm) with an average lengthening index of 1.45 months per cm. At an average follow-up of six years (range 2–15 years; 7 to maturity) all patients were satisfied with the cosmetic improvement and had full radial and ulnar deviation. Except for two patients the supination/pronation was improved. We concluded the forearm lengthening is warranted for cosmetic and functional reasons.
Logistics and Supply Chain Engineering: Perspectives on Paperless System for Highway Automatic Tollgate (HAT) through Industry 4.0. in Indonesia

Field: Engineering (Physical Sciences)

This paper elaborates discourse on Highway Automatic Tollgate (HAT) within logistics and supply chain engineering perspectives. The aforementioned HAT and its implementation are complying with the Product Design Engineering’s perspectives within theoretical and industrial implementation through Industry 4.0 in Indonesia. The objective of this paper is to intertwine the theoretical perspectives with industrial implementation. The industrial implementation constitutes the effort to implement paperless system for HAT in order to reduce wasted papers that are necessarily needed by user of this HAT, as transaction proof. The result and discussion of this paper comprise several discussions to be considered. To begin with, the result of this paperless system helps the cleaning service officers to reduce their cleaning duty. Furthermore, the result of this paperless system integrates the concept of industry 4.0 within scope of internet of things (IoT) and internet of everything (IoE). Subsequently, the discussion on this paper refers to the discourse on logistics and supply chain engineering perspectives, to ease the transaction proof involving big data. As a result, it reduces significantly the vehicle traffic and time needed to proceed to transaction in the aforementioned HAT. This paper refers to the research methodology within quantitative approach. As future research, it is indispensable to intertwine both aforementioned theoretical and industrial implementation. Both implementation, as future research, need to be integrated within the Asia Region. Keywords: big data analytics; internet of things; making Indonesia 4.0; paperless mechanism; product design engineering
COMPUTER SIMULATIONS OF THE INTERACTION OF CIGUATOXIN 3C, BREVENAL AND ent-BREVENAL LADDER POLYETHERS WITH A HOMOLOGY MODEL OF THE VOLTAGE-GATED Kv1.5 POTASSIUM CHANNEL

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The interaction of ladder polyethers of marine origin, like ciguatoxin 3C and brevenal, as well as hypothetic ent-brevenal, with the human voltage-gated Kv1.5 potassium ion channel is investigated in this work using homology modeling, automated docking, and energy scoring from molecular dynamics (MD) simulations. A 3D homology model of the pore region of the Kv1.5 channel, previously developed from the 2.9 Å resolution crystal structure of the mammalian Kv1.2 channel — which has a very similar pore sequence — is used here. While ciguatoxin 3C did not enter the pore, both brevenal and ent-brevenal were found into the pore, the latter one with the best score. Binding is attended by notable strain in the ligands, and the corresponding energy increase was evaluated for ent-brevenal by self consistent field (SCF) and density functional theory (DFT) procedures. Egress of ent-brevenal from the pore, as a microscopical reversal of the ingress, was investigated by a smart form of biased MD simulations. While this study indicates ample room and attractive interactions for both brevenal and its enantiomer into the pore, whether these molecules will be found to inhibit voltage-gated potassium ion currents depends upon the barriers in the real system to access the pore, with their thermodynamic and kinetic requirements.
Functional Genomics of Serotonin Receptor 2A (HTR2A): Interaction of Polymorphism, Methylation, Expression

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Serotonergic neurotransmission plays a key role in the pathophysiology of neuropsychiatric illnesses. The functional significance of a promoter polymorphism, -1438G/A (rs6311), in one of the major genes of this system (serotonin receptor 2A, HTR2A) remains poorly understood in the context of epigenetic factors, transcription factors and endocrine influences. We used functional and structural equation modeling (SEM) approaches to assess the contri- butions of the polymorphism (rs6311), DNA methylation and clinical variables to HTR2A expression in chronic fati- gue syndrome (CFS) subjects from a population-based study. HTR2A was up-regulated in CFS through allele-specific expression modulated by transcription factors at critical sites in its promoter: an E47 binding site at position -1,438, (created by the A-allele of rs6311 polymorphism), a gluco- corticoid receptor (GR) binding site encompassing a CpG at position -1,420, and Sp1 binding at CpG methylation site -1,224. Methylation at -1,420 was strongly correlated with methylation at -1,439, a CpG site that is dependent upon the G-allele of rs6311 at position -1,438. SEM revealed a strong negative interaction between E47 and GR binding (in con- junction with cortisol level) on HTR2A expression. This study suggests that the promoter polymorphism (rs6311) can affect both transcription factor binding and promoter meth- ylation, and this along with an individual's stress response can impact the rate of HTR2A transcription in a genotype and methylation-dependent manner. This study can serve as an example for deciphering the molecular determinants of transcriptional regulation of major genes of medical impor- tance by integrating functional genomics and SEM approa- ches. Confirmation in an independent study population is required.
Benefit of Low-Fat Over Low-Carbohydrate Diet on Endothelial Health in Obesity

Field: Medicine (Health Sciences)

Obesity is associated with impaired endothelial-dependent flow-mediated dilation, a precursor to hypertension and atherosclerosis. Although dieting generally improves cardiovascular risk factors, the direct effect of different dietary strategies on vascular endothelial function is not known. The purpose of this study was to test the hypothesis that a low-fat (LF) diet improves endothelial function compared with an isocaloric low-carbohydrate (LC) diet. Obese (n=20; body mass index: 29 to 39; mean systolic blood pressure: 107 to 125 mm Hg) and otherwise healthy volunteers were randomly assigned to either the American Heart Association modeled LF (30% fat calories) diet or an isocaloric LC Atkins’ style diet (20 g of carbohydrates) for 6 weeks (4-week weight loss and 2-week maintenance phase). Brachial flow-mediated dilation and dilation to nitroglycerin were measured with ultrasound using automated edge detection technology (baseline, week 2, and week 6). Blood pressure, weight loss, and cholesterol profiles were measured throughout the study. Weight loss was similar in LF (100±4 to 96.1±4 kg; P <0.001) and LC (95.4±4 to 89.7±4 kg; P <0.001) diets. Blood pressure decreased similarly in both groups (LF: 8/5 mm Hg; LC: 12/6 mm Hg) at 6 weeks. After 6 weeks, the percentage of flow-mediated dilation improved (1.9±0.8; P <0.05) in the LF diet but was reduced in the LC diet (−1.4±0.6; P <0.05) versus baseline. Dilation to nitroglycerin and lipid panels was similar at 0, 2, and 6 weeks. Despite similar degrees of weight loss and changes blood pressure, LF diets improved brachial artery flow-mediated dilation over LC diets. LF diets may confer greater cardiovascular protection than LC diets.
Investigate the effect of drought stress and different amounts of nitrogen and phosphorus fertilizers on oil yield and seed yield of coriander (Coriandrum sativum L.).

Field: Agricultural and Biological Sciences (Life Sciences)

In order to investigate the effect of drought stress and different amount of nitrogen and phosphorus fertilizers on seed yield and oil yield of coriander, an experiment was conducted at research field at Khorramabad-Lorestan, Iran in 2010. Field experiment was carried out by split factorial design with 3 replications. The factors studied included two levels of irrigation, irrigation after 30mm evaporation from evaporation pan (without drought stress condition) and irrigation after 70mm evaporation from evaporation pan (drought stress condition), nitrogen levels were N0,N60,N90,N120 Kg/ha and phosphorus levels were P0,P80,P100,P120 Kg/ha. The results showed that irrigation, nitrogen and phosphorus fertilizers had significant effect on oil yield and seed yield. Mean comparisons showed that highest oil yield and seed yield was obtained from irrigation after 30mm evaporation from evaporation pan and application of 90 kg/ha nitrogen and 100 kg/ha phosphorus (I30N90P100).
Frontier Cultures: A Social History of Assamese Literature

Field: Arts and Humanities (Social Sciences)

Preface. Acknowledgements Part I. Situating the Problem. Introduction 1. The Valley, 'Border' and the Question of Order 2. Buranjis and Sankari Culture: Language and Narrative in Pre-colonial Textual Traditions 3. Language Shift and Narrative: Pre-colonial Continental Crossroad to Colonial Frontier. Conclusion Part II. Literature and Socio-spatial Relations. Introduction 4. Language and Narrative: Negotiating between Difference and Contradiction 5. Narrative and Social Base: The Irony of Breakdown 6. Reinventing Frontier Narrative. Conclusion. Appendix: (a) An Account of Text and Social Origin of Author (b) Translations of Essays and Letters in Bahni. Bibliography. About the Author. Index
Spurious Elevation of Urinary Catecholamines During Therapy with Alpha-Methyl-Dopa

Field: Medicine (Health Sciences)

REFINEMENTS in techniques for the diagnosis of various forms of secondary hypertension and the introduction of effective hypotensive drugs have brightened the outlook for the hypertensive patient, but have compounded the problems of the physician. He must become increasingly aware of and wary of the possibility that the drugs which he is administering may spuriously influence the results of clinical tests on which the decision for surgical intervention may depend. For example, therapy with thiazide diuretics is frequently accompanied by hypokalemia that may be profound enough to cause the physician to suspect primary aldosteronism. Low sodium diets, sometimes employed in the treatment of hypertension, can cause an increase in the urinary excretion of aldosterone and, in certain circumstances, this too might lead to the erroneous diagnosis of primary aldosteronism. It has been shown that treatment with most of the antihypertensive drugs presently available may cause falsely positive or falsely negative
Review of: "Hepatoprotective Effect of the Ursolic Acid-Oleanolic Acid Mixture Administered Intragastrically in Mice with Liver Damage Induced by Anti-TB Drugs"

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

In In vivo assay, you didn't mention the number of animals in each group, but from results, i figured out, they are 3!!!!!! Which is insignificant.In discussion which needs to be re-written, focus on your results not previous studies; what is the mechanism by which the mixture showed this activity?Why 10 mg/kg was more efficient?
Nanocellulose reinforced polyurethane obtained from hydroxylated soybean oil

Field: Materials Science (Physical Sciences)

In this research, cellulose nanocrystals were successfully obtained from macrocrystalline cellulose and dispersed in a polyurethane matrix Cellulose nanocrystals were characterized by dynamic light scattering. Polyurethane matrix was prepared from hydroxylated soybean oil, tertiary amine catalyst and polymeric diphenyl diisocyanate. Nanocellulose reinforced polyurethane composites were successfully prepared with different concentration and good dispersion of cellulose nanocrystals. Thermal properties and tensile strength of the resulting films were evaluated and dynamic mechanical analysis was carried out. The glass transition temperature of the nanocomposites increased slightly by increasing concentration of nanocellulose. The highest tensile strength was found for the nanocomposite with 1 wt% of cellulose nanocrystals.
Functional characterization of N6- threonylcarbamoyladenosine biosynthesis by the universally conserved Sua5/YrdC and Kae1/Qri7/YgjD protein families

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

N6-threonylcarbamoyladenosine (t6A) is a universally conserved tRNA modification found on nearly all tRNA molecules that recognize ANN codons on messenger RNAs. The presence of t6A in the anticodon stem loop of tRNAs ensures proper codon recognition and high fidelity during protein translation. Cells deficient in t6A-modified tRNAs exhibit defects in starting AUG codon recognition and also an increase rate of frameshift errors during translation elongation. Although the function of t6A is critical for protein translation and cellular physiology, it was only recent that the Sua5/YrdC and the Kae1/Qri7/YgjD protein families were discovered to catalyze the formation of t6A. Archaea and eukaryotic Kae1 operate as part of the KEOPS complex with Bud32, Cgi121, Pcc1 and Gon7 proteins. Eukaryotic mitochondrial Qri7 operates in isolation. Bacterial YgjD operates as part of the YgjD-YeaZ-YjeE ternary complex. How the Sua5/YrdC family, the Kae1/Qri7/YgjD family and the additional subunits in the KEOPS and YgjD-YeaZYjeE complexes contribute to t6A biosynthesis were open questions at the beginning of my thesis work. Towards understanding the mechanisms of t6A biosynthesis, I reconstituted and\ncharacterized a minimal in vitro t6A biosynthesis reaction using Sua5 and Qri7 proteins. I established that the Sua5/YrdC and Kae1/Qri7/YgjD protein families are the core catalytic enzymes required for t6A biosynthesis and that the additional protein factors in the KEOPS and YgjD-YeaZ-YjeE complexes must serve augmenting regulatory roles. Qri7, the most primitive member of the Kae1/Qri7/YgjD family, by virtue of its ability to function on its own, operates independent of additional regulating protein factors. I then characterized the functions of the KEOPS accessory subunit Pcc1 and demonstrated that Pcc1-mediated KEOPS dimerization is not important for t6A biosynthesis by archaea KEOPS in vitro but is important for yeast KEOPS function in vivo. Lastly, I discovered and proved that human C14ORF142 is the human ortholog of yeast Gon7. This analysis showed that C14ORF142 disrupts KEOPS dimerization and potentiates the t6A biosynthesis activity of KEOPS in vitro.
Ab initio calculations of the geometries and IR spectra of two derivatives of tetramethyleneethane

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAb initio calculations of the geometries and IR spectra of two derivatives of tetramethyleneethaneYeong. Choi, Kenneth D. Jordan, Yi Hyon. Paik, Wonghil. Chang, and Paul. DowdCite this: J. Am. Chem. Soc. 1988, 110, 22, 7575–7576Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/ja00230a068https://doi.org/10.1021/ja00230a068research-articleACS PublicationsRequest reuse permissionsArticle Views60Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fourier Interpolation and Neural Network Analysis for Accurate 3D Reconstruction of Images Produced by an Inductive Sensor

Field: Computer Science (Physical Sciences)

This paper describes a novel methodology to reduce the scanning time and to extract bar dimensional information from images generated by an inductive sensor. Using a sparsely populated data set obtained from a reduced number of scan lines, faster high resolution images are generated using image interpolation techniques. Having generated these images, image filtering, peak picking and neural networks methods are applied to extract bar dimensional information and accurate 3 D visualization.
Determining protein conformation using vibrational frequencies: an ensemble approach

Field: Computer Science (Physical Sciences)

The vibrational frequencies of amides are widely used for proteins secondary structure characterisation. Prediction of protein structure based on amino acid sequence using classification approach has shown improvement with respect to accuracy, but for predicting change in structure with variation in environmental conditions, FTIR frequencies can be aptly used. In this paper an Ensemble model is constructed using, basic seven amide frequencies AMIDE A, AMIDE I, AMIDE II, AMIDE III, AMIDE IV, AMIDE V and AMIDE VI to predict the secondary structure of proteins using conformation of amino acids which are categorised as alpha helices, parallel beta sheets, anti-parallel beta sheets or omega helices. X-validation method and different performance measures are used to determine the accuracy of the model. The proposed experiment hence proves that an Ensemble approach outperforms all the other classification techniques which are used to predict the model as the accuracy of single K-NN model measured was 55.33% but when used with Bagging or Adaboost techniques of Ensemble its accuracy reaches to 94.67%.
Second-Order Nonlinear Optical Polymers: From Fundamentals to Applications

Field: Materials Science (Physical Sciences)

Successful development of materials for photonic applications requires an understanding of the nonlinear optical process, chemistry and processing of materials, and technologies for device fabrications. We are able to successfully use different chemistries to develop several types of crosslinked and networked systems. Significant progress in improving material properties has been accomplished. Promising results have been observed in several materials developed. A prototype frequency doubling device has been prepared; second harmonic Cerenkov radiation emitting green and blue light have been observed. Relevant chemical modifications to fine-tune or enhance the desired properties will need to be iteratively performed to obtain optimized properties for practical applications. Polymeric materials, High speed EO modulation, Second-order nonlinearity, Optical losses.
Redefining biological sex : a place for the intersex

Field: Social Sciences (Social Sciences)

Biological sex is commonly understood and accepted as a strict dichotomy with clear categorical boundaries. However, the nature of biological sex is far more complicated than what culture has presented it to be. In this paper I seek to understand the social construction of biological sex under a dominant gender dimorphic framework through exploring the gap between science and ideology. I refer to Judith Butler’s notion of sex as gendered to navigate through the various ways in which society has attempted to fix inconsistencies with the binary view of sex, which has both theoretical and practical implications pointing towards the incompleteness of the current definition. I argue that the traditional notion of biological sex should be redefined in light of sex variations that render the commonsense view theoretically flawed, which has further led to a series of unethical social consequences bearing on those who possess such anatomical differences.