jimnoneill/paper-to-field-training huggingface dataset:
Establishment of the Optimal Conditions for Two–Dimensional Gel Electrophoresis of Papaya Seed Proteome

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Papaya seeds are considered as a recalcitrant material for protein preparation in two-dimensional gel electrophoresis (2-DE) because of abundance of interfering compounds. We examined two protein extraction methods, the classical trichloroacetic acid (TCA)
Digital testing application in knowing the effect of servant leadership and work motivation on teacher performance

Field: Psychology (Social Sciences)

The purpose of this study was to determine the effect of servant leadership and work motivation on teacher performance in West Denpasar by using a digital-based testing application. The design of this research is descriptive quantitative on 88 teachers. Data collection techniques with questionnaires were analyzed using Structural Equation Modeling with Partial Least Squares (PLS-SEM). Research result; (1) servant leadership has a direct effect on teacher performance as indicated by a coefficient of 0.214 and a t-statistic of 6.275 (2) work motivation has a direct effect on teacher performance as indicated by a coefficient of 0.701 and a t-statistic of 32,930 (3) servant leadership has an indirect effect on teacher performance through work motivation is shown by the coefficient of 0.383 and the t-statistic of 5.216. The conclusion is that work motivation has a very strong effect on teacher performance, besides that work motivation can mediate the influence of servant leadership on teacher performance. Recommendations to apply servant leadership and work motivation to improve teacher performance.
Gap collapse and flat band induced by uniaxial strain in $1T−TaS_2$

Field: Physics and Astronomy (Physical Sciences)

Interlayer coupling is strongly implicated in the complex electronic properties of 1⁢𝑇 −TaS2. Uniaxial strain engineering offers a route to modify this coupling in order to elucidate its interplay with the electronic structure and electronic correlations. Here, we employ angle-resolved photoemission spectroscopy (ARPES) to reveal the effect of uniaxial strain on the electronic structure in 1⁢𝑇 −TaS2. The gap of the normally insulating ground state is significantly reduced, with a correlated flat band appearing close to the Fermi level. Temperature-dependent ARPES measurements reveal that the flat band only develops below the commensurate charge density wave (CCDW) transition, where interlayer dimerization produces a band insulator in unstrained samples. Electronic structure calculations suggest that the correlated flat band is stabilized by a modified interlayer coupling of the Ta 𝑑𝑧2 electrons. Further hints of a strain-induced structural modification of the interlayer order are obtained from x-ray diffraction. Our combined approach provides critical input for understanding the complex phase diagram of this platform material for correlated physics.
A Molecular Dynamics Study for Dissociation of H<sub>2</sub> Molecule on Pt(111) Surface

Field: Chemistry (Physical Sciences)

The dissociation phenomena of H2 molecule on Pt(111) surface was simulated by Molecular Dynamics (MD) method and the effect of motion of the gas molecule or surface atoms on dissociation phenomena was analyzed in detail. The Embedded Atom Method (EAM) was used to model the interaction between an H2 molecule and Pt(111) surface. Using this potential, simulations of an H2 molecule impinging on a Pt(111) surface were performed and the characteristics of the collision were observed. Using MD data the dynamic dissociation probability were obtained and compared with the static dissociation probability to analyze the effect of atomic motion on dissociation phenomena.
Restoration of Muscle-Pump Function in Chronic Venous Insufficiency

Field: Medicine (Health Sciences)

The direct venous pressure profile was recorded before and after treatment in 15 patients suffering from chronic venous insufficiency. Patients were treated conservatively, first by tight elastic support and walking exercises, then by eliminating the points of blood shunting by sclerotherapy of the incompetent perforators. The average venous pressure drop during tiptoeing was increased from 31.6% to 50.9% (P less tan 0.01), and the time required for return to the resting venous pressure level increased from an average 6 seconds to 12.9 seconds (P = 0.01). These values indicate a significant improvement in the functioning of the muscle pump of the calf, and are paralleled by clinical and subjective improvement. Wr recommend this method of treatment in cases of chronic venous insufficiency. We also wish to point out the importance of repeated direct venous pressure profile recording as a means of assessing the effectiveness of treatment in cases of venous disorders.
Controlling Lyngbya wollei in three Alabama, USA reservoirs: summary of a long-term management program

Field: Environmental Science (Physical Sciences)

Abstract Large-scale Lyngbya wollei (Cyanobacteria, Oscillatoriales) infestations are increasing throughout the USA and globally and causing significant obstruction of water resource uses. Decision makers and stakeholders encountering this nuisance organism often seek management options. Many approaches to L. wollei management may be ineffective or not applicable to specific field sites. Chemical control with United States Environmental Protection Agency registered algaecides has shown to be effective, although the specific formulation, concentration, and application frequency can all govern efficacy. This study summarizes results from a long-term and adaptive management program on extensive L. wollei infestations in three central Alabama, USA reservoirs (Lay Lake, Jordan Lake and Lake Mitchell) managed by Alabama Power Company. Multiple treatment strategies including numerous algaecides, combinations and addition of surfactants were used in attempts to control the nuisance cyanobacterium and preserve multiple beneficial functions of the resource. Ultimately, operational shift toward one technology, a double-chelated copper algaecide with surfactants and emulsifiers (Captain ® XTR) resulted in more efficient and economical control. There were significant ( P < 0.05) decreases in historic L. wollei acres requiring treatment through time on each reservoir. Throughout this study period, a 51.4, 88.1 and 94.7% percent decrease in total nuisance acres treated was realized on Lay Lake, Jordan Lake and Lake Mitchell, respectively. The large-scale and long-term dataset presented herein, covering multiple candidate treatment programs, provides valuable information to guide management decisions on other water resources impacted by L. wollei infestations.
C-reactive protein in patients with bacteremia

Field: Medicine (Health Sciences)

Quantitative measurement of C-reactive protein (CRP) in serum has been proposed as a sensitive and, for some populations, a specific indicator of infection. To determine whether early measurement of CRP in serum could differentiate patients with bacteremia from a control group of patients whose blood cultures yielded contaminants, we measured CRP concentrations quantitatively by rate nephelometry in serum samples that had been obtained from patients on the same day as blood samples that yielded bacteria or fungi. Of the 36 episodes of bacteremia, 3 (8.5%) occurred in patients with normal concentrations of CRP in serum and 2 (5.5%) in patients with minimally elevated levels. Of the 21 episodes associated with contaminated blood cultures, only 2 (9.5%) occurred in patients with normal CRP levels. Of the patients with marked elevations of CRP (greater than 10 mg/dl), 18 (86%) had infection, although not all of these patients had bacteremia. We conclude that a normal concentration of CRP in serum does not eliminate the possibility of bacteremia. Moderate elevations (1 to 10 mg/dl) of CRP levels are common in both patients with contaminated blood cultures and in those with bacteremia. If the CRP concentration in serum is greater than 10 mg/dl and if other causes of marked elevations of CRP levels are eliminated, CRP concentration in serum may be a relatively specific indicator of infection. However, elevations of CRP concentrations are neither completely sensitive nor specific for detecting infection in patients with bacteremia.
Active Vibration Control for a Machine Tool With Parallel Kinematics and Adaptronic Actuator

Field: Engineering (Physical Sciences)

The use of adaptronic components opens up interesting new possibilities for modern machine tools such as parallel kinematics. In this paper, two active vibration control concepts are designed for an adaptronic component of a parallel kinematic machine tool. The machine tool is modeled as a flexible multibody system model including a nonlinear flatness-based position control. Both the combination of a frequency shaped linear quadratic regulator with an active damping concept in a high authority control/low authority control approach and the H2 optimal control with gain scheduling show a high potential in the simulation to significantly increase the disturbance rejection or the tracking performance of the machine tool.
Collaborative data sharing: The International Acute Myeloid Leukemia Consortium (INTERACT).

Field: Medicine (Health Sciences)

169 Background: Outcomes for children and adolescents/young adults (AYAs) with acute myeloid leukemia (AML) remain suboptimal and are decidedly poor for patients with subtypes defined by high-risk features, including canonical genetic alterations and relapsed/refractory presentation. Due to their rarity, these subtypes are difficult to study within the existing clinical trials paradigm. Data sharing efforts aim to increase our understanding of rare cancer subtypes by pooling data from multiple sources. The INTERnational Acute myeloid leukemia ConsorTium (INTERACT) was established to pool and share data on pediatric and AYA patients with AML. Methods: In 2019, a data dictionary was created through an iterative, consensus-driven process that analyzed pre-existing clinical trials case report forms as the initial basis. By developing this standardized representation for data on patients with AML, data could be harmonized and integrated. A memorandum of understanding was signed in 2021, formally establishing INTERACT. An executive committee was convened to establish scientific priorities, facilitate ongoing data dictionary work, usher agreements with data contributors and review data requests submitted by investigators. In January 2024, the initial set of AML data was released on the Pediatric Cancer Data Commons (PCDC) data portal. Results: As of April 2024, the data dictionary includes 157 standardized data elements that were used to harmonize clinical data on 3,413 patients who participated in seven clinical trials conducted by four pediatric oncology cooperative groups across the United States, Europe, and Asia. Elements in the data dictionary include demographics, initial disease characteristics, genetic alterations, and survival status. Aggregate data can be freely explored using the publicly-available PCDC data portal (portal.pedscommons.org) and investigators seeking line-level access to data may submit a project request to the INTERACT executive committee for consideration. Conclusions: International collaborative data-sharing efforts will advance our understanding of pediatric and AYA AML by reducing barriers that constrain our study of AML to smaller cohorts of data. We hope that an early outcome of data sharing will be to increase our understanding of optimal treatments for patients with relapsed/refractory disease. Future goals of INTERACT include identifying data from additional studies to include, establishing relationships with new data contributors, and establishing working groups to advance the consortium’s scientific and clinical trials goals.
Implementing the Fatigue Guidelines at One NCCN Member Institution: Process and Outcomes

Field: Health Professions (Health Sciences)

Fatigue, despite being the most common and distressing symptom in cancer, is often unrelieved because of numerous patient, provider, and system barriers. The overall purpose of this 5-year prospective clinical trial is to translate the NCCN Cancer-Related Fatigue Clinical Practice Guidelines in Oncology and NCCN Adult Cancer Pain Clinical Practice Guidelines in Oncology into practice and develop a translational interventional model that can be replicated across settings. This article focuses on one NCCN member institution's experience related to the first phase of the NCCN Cancer-Related Fatigue Guidelines implementation, describing usual care compared with evidence-based guidelines. Phase 1 of this 3-phased clinical trial compared the usual care of fatigue with that administered according to the NCCN guidelines. Eligibility criteria included age 18 years or older; English-speaking; diagnosed with breast, lung, colon, or prostate cancer; and fatigue and/or pain ratings of 4 or more on a 0 to 10 screening scale. Research nurses screened all available subjects in a cancer center medical oncology clinic to identify those meeting these criteria. Instruments included the Piper Fatigue Scale, a Fatigue Barriers Scale, a Fatigue Knowledge Scale, and a Fatigue Chart Audit Tool. Descriptive and inferential statistics were used in data analysis. At baseline, 45 patients had fatigue only (≥ 4) and 24 had both fatigue and pain (≥ 4). This combined sample (N = 69) was predominantly Caucasian (65%), female (63%), an average of 60 years old, diagnosed with stage 3 or 4 breast cancer, and undergoing treatment (82%). The most common barriers noted were patients' belief that physicians would introduce the subject of fatigue if it was important (patient barrier); lack of fatigue documentation (professional barrier); and lack of supportive care referrals (system barrier). Findings showed several patient, professional, and system barriers that distinguish usual care from that recommended by the NCCN Cancer-Related Fatigue Guidelines. Phase 2, the intervention model, is designed to decrease these barriers and improve patient outcomes over time, and is in progress.
Design of Self-Constructing Recurrent-Neural-Network-Based Adaptive Control

Field: Computer Science (Physical Sciences)

This paper develops a recurrent-neural-network-based adaptive control (RNNAC) system with structure adaptation algorithm, which is composed of a neural controller and a robust controller. In the neural controller design, a self-structuring recurrent neural network (SRNN) is utilized to mimic an ideal tracking controller. In the SRNN approximator, a dynamic generating and pruning mechanism of the neural stricture is developed to cope with the tradeoff between the approximation accuracy and computation load. The robust controller is designed to attenuate the effects of the approximation error on the tracking performance using L2 tracking technique. Finally, the developed RNNAC system is used to control a nonlinear chaotic dynamic system to demonstrate its effectiveness. Simulation results indicate that a small attenuation level can be achieved if the magnitude of weighting factor is chosen small.
Data from Elucidating the Genetic Landscape of Oral Leukoplakia to Predict Malignant Transformation

Field: Medicine (Health Sciences)

<div>AbstractPurpose:<p>Oral leukoplakia is the most common oral potentially malignant disorder with an annual malignant transformation rate of 1% to 5%. Consequently, oral leukoplakia patients have a 30% to 50% lifetime risk to develop oral squamous cell carcinoma. Although risk factors for malignant transformation of oral leukoplakia have been investigated, no definitive risk stratification model has been proposed. Next-generation sequencing can elucidate the genetic landscape of oral leukoplakia, which may be used to predict the risk for malignant transformation.</p>Experimental Design:<p>We investigated a retrospective cohort of 89 oral leukoplakia patients, and analyzed their oral leukoplakia lesions for the presence of genomic copy-number alterations and mutations in genes associated with oral squamous cell carcinoma.</p>Results:<p>In 25 of 89 (28%) patients, oral squamous cell carcinoma developed during follow-up. Seventy-nine of 89 (89%) oral leukoplakias harbored at least one genetic event. Copy-number alterations were present in 61 of 89 (69%) oral leukoplakias, most commonly gains of chromosome regions 8q24 (46%) and 20p11 (20%) and loss of 13q12 (19%). Mutations were present in 59 of 89 (66%) oral leukoplakias, most commonly in <i>TP53</i> (28%), <i>FAT1</i> (20%), and <i>NOTCH1</i> (13%). Genetic data were combined with the presence of dysplasia to generate a prediction model, identifying three groups with a distinct risk for malignant transformation.</p>Conclusions:<p>We provide an extensive description of genetic alterations in oral leukoplakia and its relation to malignant transformation. On the basis of our data we provide a model for the prediction of malignant transformation of oral leukoplakia using dysplasia and genetic markers.</p></div>
Children's Mental Models of Recursive Logo Programs

Field: Computer Science (Physical Sciences)

Children who had a year of Logo programming experience were asked to think-aloud about what brief Logo recursive programs will do, and then to predict with a hand-simulation of the programs what the Logo graphics turtle will draw when the program is executed. If discrepancies arose in this last phase, children were asked to explain them. A prevalent but misguided “looping” interpretation of Logo recursion was identified, and this robust mental model persisted even in the face of contradiction between what the program did when executed and the child's predictions for what it would do.
Properties preservation during transformation

Field: Computer Science (Physical Sciences)

Abstract. To prove the correctness of a program (written in a high level programming language) with respect to a specification (a set of proof obligations) does not assure the correctness of the machine code that the end-user will run after compilation and deployment phases. The code generated by the compiler should be verified again to guarantee that its correctness was preserved, and then that it can be executed in safety. In the context of a Ph.D. work in the area of software analysis and transformation, we are looking for a suitable approach to prove that the software properties (validated at source level) are kept during translation. In this position paper we introduce our architectural proposal, and dis-cuss the platform and we are building for Java+JML on the top of Eclipse.
Management of Hyperglycemia in Diabetic Kidney Disease

Field: Medicine (Health Sciences)

Diabetes has reached epidemic proportions in Korea and worldwide, and is associated with increased risk for chronic kidney disease (CKD) and end-stage kidney disease (ESKD). Given the increasing prevalence of diabetes and its high morbidity and mortality, diabetic kidney disease (DKD) represents a serious concern in individual patients and a considerable socioeconomic burden. The kidneys contribute to glucose homeostasis through processes of gluconeogenesis, glucose filtration, glucose reabsorption, and glucose consumption. Decreased nephron mass and kidney dysfunction due to DKD progression lead to the complicated state that causes both hypoglycemia and hyperglycemia. Appropriate management tailored for DKD patients is required to improve their morbidity and mortality. This review focuses on special issues related to the management of DKD, including clinical kidney outcomes in DKD progression, glycemic control indices and targets for diabetes mellitus (DM) CKD, glucose management of advanced DM CKD or ESKD and tailored medications for DKD based on clinical evidence. Keywords: Biomarkers; Diabetes mellitus; Diabetic nephropathies; Therapeutics
Correlates of Life Satisfaction among Aboriginal Adolescents

Field: Social Sciences (Social Sciences)

Background and Purpose: To investigate the correlates of life satisfaction among aboriginal adolescents in northern Taiwan. Methods: This study was a panel design follow-up survey. In total, 234 aboriginal adolescent participants from a preliminary survey (N=318) were recruited into this follow-up survey. Data were collected through face-to-face interviews, using structured questionnaires. Results: Findings indicated five leading causes of subjects' daily life distress: poor academic performance (50.9%), economic difficulties (40.6%), relationships and/or emotional problems (26.9%), health problems (15.8%), and poor family communication (15.4%). Overall, 79.5% of the subjects perceived their health status as being good, and 66.2% were satisfied with their lives. Roughly 53.4% showed poor academic performance, yet 76.9% felt stressed about this. According to the multiple logistic regression analyses, subjects without economic problems (OR=2.08, 95% CI=1.06-4.08) and those willing to publicly reveal themselves as being aboriginal (OR=2.73, 95% CI=1.37-5.43) were more likely to be satisfied with their current lives than their counterparts. Conclusion: Economic factors and a willingness to reveal oneself as an aborigine were two of the strongest predictors for subjects' life satisfaction.
Nutrient Accumulation in Cover Crops under Contrasting Water Regimes in the Brazilian Cerrado

Field: Agricultural and Biological Sciences (Life Sciences)

Brazilian Cerrado has a dry period, and the inclusion of new species for diversification in the production system needs to be drought-tolerant. This work aimed to evaluate biomass and nutrient accumulation in species with potential as cover crops and grain crops under different water levels. Irrigation treatments were obtained through an irrigation bar with sprinklers with increasing water flows to create a continuous gradient. The experimental design randomized complete blocks in split plots with four replications. The main plots were composed of four water regimes (167 mm, 268 mm, 381 mm and 432 mm), and the subplots were formed by the following cover crops: Amaranthus cruenthus, Chenopodium quinoa and Pennisetum glaucum, the latter already used for this purpose. Amaranthus cruenthus and P. glaucum recorded the highest dry biomass (10.16 and 9.75 Mg ha−1, respectively). Dry biomass production and the cellulose contents decreased with the reduction of water availability for all species. A. cruenthus was the species that most accumulated P (37.42 kg ha−1), K (416.92 kg ha−1), Mg (30.88 kg ha−1), S (43.53 kg ha−1), Fe (2.22 kg ha−1), B (0.124 kg ha−1) and Zn (0.240 kg ha−1). Amaranthus cruenthus produced the highest yield. Under high and low water availability conditions, A. cruenthus presents potential as a cover crop and grain cash crop, in addition to accumulating more nutrients; P. glaucum has potential as a cover crop and C. quinoa only for grain production.