jimnoneill/paper-to-field-training huggingface dataset:
Optimisation of Machining Parameters for CNC Milling of Fibre Reinforced Polymers

Field: Engineering (Physical Sciences)

The objective of the presented work is to improve the machining parameters of fibre reinforced polymer (FRP) using Taguchi's robust design technique. A large number of variables impact the quality of the completed component throughout the machining process. The quality of machined FRP components is greatly influenced by the surface roughness. Manufacturers can make sure that the finished product fulfils the necessary quality requirements and is cost-effective by optimizing machining settings to achieve the specified surface roughness. Optimizing machining parameters for achieving the desired surface roughness can help reduce production costs by minimizing waste, improving tool life, and reducing the need for post-processing operations. To optimize the process, Three levels of each parameter were chosen for investigation for each such adjustable process parameter. Machining was performed on a CNC milling machine using a carbide end mill. Experiments were conducted utilising Taguchi's technique to generate an experiment design (L9 orthogonal array). Analysis of variance was used to determine the impact of each parameter (ANOVA). The recommended control factor values for the best possible surface finish of FRP are 1.64 m, 400 rpm spindle/cutting velocity, 1.5 mm depth of cut and 0.3 millimetre/revolution feed rate. Surface roughness was shown to be most impacted by cutting speed, followed by feed rate and depth of cut. To determine the relationship between process parameters and quality attributes, regression analysis and response surface methodology was used.
Abstract 2861: Inhibition of mTOR and AKT as a potential strategy for the treatment of basal-like breast cancer

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Basal-like breast cancer is an aggressive disease, for which effective targeted therapies are lacking. The frequent loss of phosphatase and tensin homolog (PTEN) and aberrant activation of phosphatidylinositol 3-kinase (PI3K)-AKT-mTOR pathway in basal-like breast cancer make it an attractive therapeutic strategy to target AKT and mTOR. To evaluate the effect of PTEN loss on tumor cell sensitivity to mTOR inhibition, we performed PTEN knockdown experiment in vitro using a basal-like breast cancer cell line WU-BC3, which was derived from a patient with triple negative breast cancer. A more dramatic reduction in cell proliferation was observed in WU-BC3 siPTEN compared to that in WU-BC3 siControl following 7 days of treatment with the mTOR inhibitor MK-8669 (p&lt;0.001). We then tested MK-8669 and MK-2206 (an allosteric, selective pan-AKT inhibitor), either alone or in combination, in 2 Human Tumor in Mouse (HIM) models of basal-like breast cancer, WU-BC4 and WU-BC5, that are deficient in PTEN expression in vivo. In both models, MK-8669 alone significantly inhibited tumor growth (p&lt;0.001). However, the combination of MK-8669 and MK-2206 was more effective than either MK-8669 (p&lt;0.05) or MK-2206 (p&lt;0.01) alone. Biomarker studies indicated that the combination therapy resulted in a more dramatic inhibition of tumor cell proliferation (as assessed by Ki67) and angiogenesis (as assessed by CD31 staining) than single agents alone in both models. In addition, treatment with MK-2206 abolished the MK-8669-induced AKT activation in vivo, suggesting the inhibition of the feedback loop between mTOR and AKT being a potential underlying mechanism for the enhanced anti-tumor effect observed with the combination therapy. Our results provide a preclinical rationale for future clinical investigation of this combination in basal-like breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2861. doi:1538-7445.AM2012-2861
Manuscript Illumination in 19th-century Italy. Material Analysis of Two Partial Copies from the Squarcialupi Codex

Field: Arts and Humanities (Social Sciences)

Abstract The illuminations in two Italian manuscripts are still a mystery today. Both manuscripts were based fully or partly on the Florentine Squarcialupi Codex (Florence, Biblioteca Medicea Laurenziana, Med. Pal. 87) dating from around 1410/15. With the help of a multi-analytical, non-destructive approach employing mobile instrumentation (XRF spectroscopy, visible reflectance spectroscopy and infrared reflectography), we examined the manuscripts Toronto, Thomas Fisher Rare Book Library, MSS 09700 and Düsseldorf, Kunstpalast, Inv. K 1925-67 for the first time with regard to their production processes. The identification of modern pigments allows them to be contextualized in illumination practices of the 19 th century. Manuals of that time provide a wealth of information on specific illumination practices and the availability of writing and painting materials, which correlates with the actual artefacts.
Analysis and Evaluation of Nutritional Components in Muscle of Cultured Synechogobius ommaturus

Field: Agricultural and Biological Sciences (Life Sciences)

The nutritional components and quality in muscle of cultured Synechogobius ommaturus were analyzed and evaluated by biochemical analysis methods. The results show ed that the moisture,crude protein,crude fat,and crude ash contents of fresh muscle of S. ommaturus w ere( 82.10±0.21) %,( 15.34±0.20) %,( 0.87±0.13) %,and( 1.12±0.03) %,respectively. Glu( 12.71%),Asp( 8.42%),Lys( 8.16%),and Leu( 6.51%) were the highest contents in 18 kinds of found amino acids in dry muscle. Total amino acid( TAA),total essential amino acid( EAA),and total delicious amino acid( DAA) contents of dry muscles w ere83.36%,31.40%,and 31.79%,respectively. The EAA /TAA and EAA /NEAA w ere( 37.65 ±0.63) % and( 70.10±1.90) %,respectively; according to nutrition evaluation in amino acids score( AAS) and chemical score( CS),the first limited amino acid w as Trp,the second limited amino acid w as Val; the essential amino acid index( EAAI) and the ratio of branched chain amino acid to aromatic amino acid( F value) w ere 70.19%and 2.22,respectively. The saturated fatty acids( ∑SFA),poly-unsaturated fatty acids( ∑PUFA),∑ n3 PUFA,and EPA +DHA w ere( 30.23±0.48) %,( 49.52±0.91) %,( 39.54±1.12) %,and( 42.47±1.10) %,respectively. Therefore,S. ommaturus is nutritional,delicious,and healthy to human,and is a new potential candidate for aquaculture.
Properties of the Two-Dimensional Electron-Gas of a Hybrid MgZnO/InGaN/ZnO Heterostructure with an InGaN Channel Layer

Field: Materials Science (Physical Sciences)

The polarization effect on a two-dimensional electron gas (2DEG) in a the ZnO/InGaN/MgZnO high electron mobility transistor (HEMT) was theoretically investigated as a function of the In content and the InGaN layer thickness. The electron density in the ZnO/InGaN/MgZnO HEMT is shown to be enhanced with increasing In content. In particular, in the case of the HEMT structure with a relatively high In content of 0.2, we find that the confinement of the electron gas is signifi- cantly improved. Also, the electron density increases linearly with increasing layer thickness because the potential difference between the MgZnO/InGaN and the InGaN/ZnO interfaces increases with increasing layer thickness. As a result, the carrier confinement in the MgZnO/InGaN/ZnO HEMT structure is shown to be superior to that in the conventional MgZnO/ZnO HEMT structure.
Mammography Screening in Women Under Age 50 Years

Field: Medicine (Health Sciences)

To the Editor.— The article by Eddy et al 1 provides evidence that healthy asymptomatic women between the ages of 40 and 49 years do not show sufficient health or economic benefit from mammography to offset the costs and risks. They contend that the costs for screening this cohort are high and that relatively few lives would be saved. Their data indicate that mammography screening in that decade would carry a risk of radiation-induced cancer of the breast of about 1 in 25 000. They conclude that a more prudent approach is to initiate mammography at age 50 years. The matter of hereditary breast cancer (HBC) was totally ignored in these reports. This is surprising since HBC accounts for approximately 9% of the total breast cancer burden 2 and its average age of onset is approximately 44 years. 3,4 Indeed, we recently described a subset of HBC that is characterized
S1P-Induced TNF-α and IL-6 Release from PBMCs Exacerbates Lung Cancer-Associated Inflammation

Field: Medicine (Health Sciences)

Sphingosine-1-phosphate (S1P) is involved in inflammatory signaling/s associated with the development of respiratory disorders, including cancer. However, the underlying mechanism/s are still elusive. The aim of this study was to investigate the role of S1P on circulating blood cells obtained from healthy volunteers and non-small cell lung cancer (NSCLC) patients. To pursue our goal, peripheral blood mononuclear cells (PBMCs) were isolated and stimulated with S1P. We found that the administration of S1P did not induce healthy PBMCs to release pro-inflammatory cytokines. In sharp contrast, S1P significantly increased the levels of TNF-α and IL-6 from lung cancer-derived PBMCs. This effect was S1P receptor 3 (S1PR3)-dependent. The pharmacological blockade of ceramidase and sphingosine kinases (SPHKs), key enzymes for S1P synthesis, completely reduced the release of both TNF-α and IL-6 after S1P addition on lung cancer-derived PBMCs. Interestingly, S1P-induced IL-6, but not TNF-α, release from lung cancer-derived PBMCs was mTOR- and K-Ras-dependent, while NF-κB was not involved. These data identify S1P as a bioactive lipid mediator in a chronic inflammation-driven diseases such as NSCLC. In particular, the higher presence of S1P could orchestrate the cytokine milieu in NSCLC, highlighting S1P as a pro-tumor driver.
272 Efficacy of coronary artery bypass grafting combined with surgical ventricular restoration on the function of the ventricles in patients with is chaemic dilated cardiomyopathy

Field: Medicine (Health Sciences)

Results: E/Ea did nol change significantly during exercise (20±8 al resl vs 23±12 at exercise, p=0.07).E/Ea at rest as well as al peak lesl correlaled well wilh translricuspid pressure gradienl (r=0.41 and r=0.58, p<0.01).At peak exercise, E/Ea increased in 27 (8.4±8.9)palienls and decreased (-3.3±4.2) in lhe olhers.The increase in E/Ea during exercise was associalod with a decrease in slroke volume (-3.2±17 ml vs 15±15, p=0.0025), an increase in MR severily (changes in ERO 13±8 vs 5±9 mm 2 , p=0.0045), in Iranstricuspid pressure gradienl (25±12 vs 16±13 mmHg, p=0.012) and in E peak (43±26 vs 264-99 cm/s, p=0.0006).Patients who stopped lhe tesl lot dyspnea presenled a larger rise in Iranslricuspid pressure gradienl, in MR severity and in E/Ea al peak test.With mullivariale analysis, dynamic increase in MR severily at exercise remained the sole prediclor el exerlional dyspnea (p=0.01). Conclusion:In palienls wilh syslolic heart lailure, changes in E/Ea during e~ercise are highly variable from patient Io pstienl and appeared to be relaled Io bolh lhe dynamic componenl of MR and reduced LV compliance.
Morbidity and risk factors for multiple noncommunicable diseases in Northern China: a cross-sectional survey.

Field: Medicine (Health Sciences)

The prevalence of chronic glucolipid metabolic noncommunicable diseases in Pinggu was higher than at the national level. Men with multiple noncommunicable diseases were younger, while women after menopause were more likely to suffer from multiple noncommunicable diseases and the prevalence rate was higher than in men. Intervention programs that aim to target risk factors by sex and region-specific are urgently needed.
EducatingThe Simpsons: Teaching Queer Representations in Contemporary Visual Media

Field: Arts and Humanities (Social Sciences)

ABSTRACT This article analyzes queer representation in contemporary visual media and examines how the episode "Homer's Phobia" from Matt Groening's animation series The Simpsons can be used to deconstruct hetero- and homo-sexual codes of behavior, socialization, articulation, representation and visibility. The analysis is contextualized in the interaction between mainstream and independent cinemas, and particularly, the rise of the New Queer Cinema and Television in the 1990s and the representation/exploitation of queer subjectivities in TV sitcoms of that period.
Cardiac activation mapping in a transgenic mouse model of cardiac hypertrophy

Field: Neuroscience (Life Sciences)

Genetically altered mice have been developed to study many aspects of cardiac membrane electrophysiology. Observations made at the cellular level in these transgenic mice are often not correlated with the ECG from the intact animal. Transgenic (N=4) and control (N=4) mice were studied with hardware and software tools developed to observe epicardial activation. A custom probe mapped the anterior right ventricle using 16 unipolar electrodes arranged in a 4/spl times/4 matrix (1.0 mm/sup 2/). Labview software controlled the digitization, storage and real time display of the signals. With Matlab programs, local activation times were identified and isochronous maps and spatial velocity vectors were constructed. The direction of the activation wavefront shifted 90/spl deg/ in the transgenic mice when compared to the control group. Such changes in the conduction patterns may help demonstrate macroscopic conduction abnormalities resulting from cellular communication differences in the genetically altered mice as compared to control mice.
Photovoltaic Electrochemically Driven Degradation of Calcon Dye with Simultaneous Green Hydrogen Production

Field: Chemical Engineering (Physical Sciences)

In this study, for the first time, the production of green hydrogen gas (H2) in the cathodic compartment, in concomitance with the electrochemical oxidation (EO) of an aqueous solution containing Calcon dye at the anodic compartment, was studied in a PEM-type electrochemical cell driven by a photovoltaic (PV) energy source. EO of Calcon was carried out on a Nb/BDD anode at different current densities (7.5, 15 and 30 mA cm−2), while a stainless steel (SS) cathode was used for green H2 production. The results of the analysis by UV-vis spectroscopy and total organic carbon (TOC) clearly showed that the electrochemical oxidation (EO) of the Calcon dye after 180 min of electrolysis time by applying 30 mA cm−2 reached up to 90% of degradation and 57% of TOC removal. Meanwhile, under these experimental conditions, a green H2 production greater than 0.9 L was achieved, with a Faradaic efficiency of 98%. The hybrid electrolysis strategy is particularly attractive in the context of a circular economy, as these can be coupled with the use of more complex water matrices to transform organic depollution into an energy resource to produce H2 as a chemical energy carrier.
POSTHARVEST MANUAL ANSWERS MANY QUESTIONS

Field: Agricultural and Biological Sciences (Life Sciences)

Many authors have noted that consumer confidence in buying fresh flowers is strongly related to their perceived value in that quality and vase life must be high and consistent over time for consumers to repeat buy. Growers, wholesalers, exporters and retailers seek practical information about recommended handling and treatments at the harvest and postharvest stages, including that relating to flowers native to Australia and South Africa (wildflowers). This information is essential for products to be of high quality with an acceptable vase life for the end consumer, especially if exported. Published postharvest manuals generally focus on traditional flower crops and so rarely include many, or any, wildflowers. A manual entitled Postharvest Handling of Australian flowers from Native Plants and Related Species was published in 2002 and addressed this gap, but required updating. This situation presented an opportunity to provide in-depth information to compliment the Australian wildflower quality specifications (see accompanying paper in the same volume), and to assemble the latest knowledge on wildflower quality and postharvest issues. The resultant manual contains extensive information about harvesting, quality issues and recommended postharvest care focussed on wildflowers. Much of the information is documented for the first time, being based on the most up to date research and development (R&D) as well as practical experience of the floral supply chain, researchers and other technical experts. The manual provides practical and detailed information on postharvest treatment of fresh wildflowers for growers, florists, wholesalers and exporters to use on a daily basis. It discusses the many unique features of wildflowers that must be understood and managed in order to maximise their quality and vase life after marketing and export. The manual also includes postharvest advice for 16 flower- and foliage lines for which quality specifications were not produced. This advice is presented according to the same template as the specifications.
Pengaruh Pengalaman Kerja, Karakteristik Individu Dan Iklim Organisasi Terhadap Kinerja Pegawai Badan Pengelolaan Pajak Dan Retribusi Daerah Provinsi Sumatera Utara

Field: Business, Management and Accounting (Social Sciences)

The Influence of Work Experience, Individual Characteristics and Organizational Climate on Employee Performance at Badan Pengelolaan Pajak Dan Retribusi Daerah Provinsi Sumatera Utara, guided by Mr. Dr. Nur. M. Ridha Tarigan, S.E.,M.M, as chairman, Mr. Dr. Syofyan, SE, M.Si and Mrs. Dr. Sri Gustina Pane, SE.,M.Si, as member, Thesis – 2022. The formulation of the problem in this study are: How do work experience, individual characteristics and organizational climate influence employee performance? This study aims to determine the effect of work experience, individual characteristics and organizational climate on employee performance. By using the Slovin formula and the Probalility Sampling technique, the sample is 88 people. The results are; Work experience partially has a positive effect on employee performance; Individual characteristics partially have a positive effect on the morale of employee performance; Organizational climate partially has a positive effect on employee performance; Work experience, individual characteristics and organizational climate simultaneously have a positive effect on employee performance
ORIGIN OF FAR-FIELD N18 OF SSEPS IN RESPONSE TO MEDIAN NERVE STIMULATION

Field: Neuroscience (Life Sciences)

We examined N18 somatosensory evoked potentials (SSEPs) in response to left median nerve stimulation in ten normal adults using three methods : potential map, source derivation (SD) map, and dipole localizing method (DLM). SSEPs from ten subjects were averaged and analyzed for a period of 128 msec. In the potential map and the map calculated by using SD, N18 was distributed mainly in the centro-pariental region contralateral to that potential. DLM presented a pair of dipoles equivalent to N18, Which were parallel and Directed opposite to each other. From these observations, we speculate that N18 has at least two generators, one at the level between the midbrain and the thalamus and the other in the lower brainstem.
Supplementary Figure from Phase I Clinical Trial of DNA Methyltransferase Inhibitor Decitabine and PARP Inhibitor Talazoparib Combination Therapy in Relapsed/Refractory Acute Myeloid Leukemia

Field: Medicine (Health Sciences)

Supplementary Figure from Phase I Clinical Trial of DNA Methyltransferase Inhibitor Decitabine and PARP Inhibitor Talazoparib Combination Therapy in Relapsed/Refractory Acute Myeloid Leukemia
Abstract 16135: Higher Body Mass Index in Early Childhood is Associated With Adult Obesity in Patients With a Fontan Circulation

Field: Medicine (Health Sciences)

Introduction: Obesity is associated with comorbidities that may be detrimental to single-ventricle patients who have had a Fontan procedure. We assessed the prevalence of obesity in adults with a Fontan circulation and evaluated the hypothesis that higher body mass index (BMI) in early childhood is associated with obesity in adulthood. Methods: Retrospective cohort study of patients with a Fontan circulation aged 18-32 years, seen 2011-2019. Those with an atriopulmonary Fontan or chromosomal abnormality known to affect growth were excluded. Historical height and weight measurements, results of recent cardiac testing, and body mass index (BMI) over time were recorded. Obesity was defined as BMI ≥30 kg/m 2 . The associations between childhood anthropometrics, adult BMI, and most recent cardiac testing were assessed. Results: The cohort included 113 adults with a Fontan circulation (median age 22.7 [IQR 20.2-26.4] years; 44% female). There were no significant differences in age, age at Fontan, Fontan type, or ventricular morphology between obese (n=21, 19%; 52% female) and non-obese (n=92, 81%; 41% female) patients. Compared to non-obese adults, obese patients had higher BMI percentiles at age 2 years (80 th [33-95] vs 43 rd [13-82] percentile, p=0.02), at age 4 years (90 th [73-93] vs 57 th [22-81] percentile, p=0.002), and at the time of the Fontan procedure (85 th [51-98] vs 20 th [5-57] percentile, p=0.002). Being overweight at time of Fontan (BMI percentile >85%) strongly predicted later obesity (OR=18.3, 95% CI 3.7-90.3, p<0.001). Obese adults had lower peak VO 2 (19.1±5.2 vs 25.5±6.6 mL/kg/min, p<0.001,) a trend to a lower % predicted VO 2 (59±13 vs 65±14% predicted, p=0.06), higher systolic blood pressure (121±17 vs 112±12 mmHg, p=0.007) and higher ventricular end-diastolic pressure (11±4 vs 9±3 mmHg, p= 0.03). Adult BMI weakly correlated with ventricular end-diastolic pressure (r=0.24, p=0.048). Conclusions: Higher BMI in early childhood is associated with obesity in adults with a Fontan circulation. Adult obesity is associated with worse exercise capacity, higher blood pressure, and higher ventricular end-diastolic pressure. Weight interventions in children with a Fontan circulation may help prevent later obesity and its adverse consequences.