jimnoneill/paper-to-field-training huggingface dataset:
Endothelial Progenitor Cells in Breast Cancer

Field: Medicine (Health Sciences)

Recent evidences demonstrated the importance of bone marrow derived Endothelial Progenitor Cells (EPC), in the contribution to postnatal physiological and pathological neovascularization, and in tumor growth and angiogenesis. These cells are recruited undifferentiated, in response to systemic or chemoatractive signals, such as Vascular Endothelial Growth Factor (VEGF), they lodge in the growing or lesioned tissue and differentiate into endothelial cells in response to local stimuli and cell-cell interactions. The extent and the significance of the EPCs contribution for the growing of most tumors, including those of the breast, are still not fully defined. We analyzed the peripheral blood of breast cancer patients and found that they have circulating EPCs. We also found an association between expression of AC133+Kdr+ and VEGF plasma levels in these patients. Strategies to impair the mobilization and incorporation of EPCs into breast tumors may contribute to halt the growth of these tumors.
Tailoring anisotropic synthetic inflow turbulence generator for wind turbine wake simulations

Field: Engineering (Physical Sciences)

In computational fluid dynamics, defining precise boundary conditions, especially at inlets, is of great importance. Inlet flows typically exhibit natural turbulence, which is managed in various ways in scale-resolving simulations. Methods to establish turbulent inlet conditions are commonly created using natural transition, uncorrelated oscillations, periodic boundary conditions from auxiliary simulations, or synthetic turbulent fields. In this study, we explore a technique aimed at generating a divergence-free synthetic inflow turbulence with arbitrary anisotropy. The methodology is based on the conventional portrayal of turbulence as consisting of several coherent structures. While our approach adeptly emulates predefined statistical characteristics across different scales, its primary focus is on generating input parameters that impact the airflow within the wake of individual wind turbines and the atmospheric boundary layer within a wind farm. The results are compared with high-resolution velocity experimental measurements, large eddy simulations, and the digital filter-based inlet boundary condition already available in OpenFOAM. The findings demonstrate that the applied inflow generator outperforms the default OpenFOAM filter, particularly in the context of a single wind turbine.
Longitudinal associations between functional disability, depression, and suicide in middle-aged and older adults

Field: Medicine (Health Sciences)

Suicide is a significant public health problem among older adults in the United States and around the world. There has been little research to date on longitudinal change in functional disability and depressive symptoms, both of which have been posited to be associated with suicide risk among middle-aged and older adults, and their association with death by suicide. The aims of this study were to 1) characterize longitudinal change in functional disability and depressive symptoms separately; 2) characterize the directional associations between functional disability and depressive symptoms in bivariate models; and 3) determine how different patterns of change among these variables are associated with risk for death by suicide. The study used two larger population-based longitudinal datasets, the Health and Retirement Study (HRS) in the United States, and the Swedish Twin Registry (STR). Results from HRS indicated that change in functional disability and depressive symptoms is characterized by a complex system of effects, including both systematic, linear change effects and proportional change based on the level of each variable at each wave. Functional disability generally increased across time and depressive symptoms remained relatively stable, with some slight increases. A bivariate model where level of disability was associated with subsequent change in depressive symptoms was supported by the data, and latent class membership representing group differences in patterns of change within this model predicted risk for death by suicide. Cognitive impairment was significantly associated with lower risk for death by suicide, and appeared to have a suppressor effect on the association of class membership with death by suicide. In STR, functional disability did not predict risk for death by suicide. Further research is needed to characterize the complex longitudinal associations between disability and depression and their effects on suicide risk, taking into account cognitive status.
Gab1 adaptor protein acts as a gatekeeper to balance hepatocyte death and proliferation during acetaminophen‐induced liver injury in mice

Field: Medicine (Health Sciences)

Acetaminophen (APAP) overdose is the leading cause of drug‐induced acute liver failure. In APAP‐induced acute liver failure, hepatocyte death and subsequent liver regeneration determines the prognosis of patients, making it necessary to identify suitable therapeutic targets based on detailed molecular mechanisms. Grb2‐associated binder 1 (Gab1) adaptor protein plays a crucial role in transmitting signals from growth factor and cytokine receptors to downstream effectors. In this study, we hypothesized that Gab1 is involved in APAP‐induced acute liver failure. Hepatocyte‐specific Gab1 conditional knockout ( Gab1 CKO) and control mice were treated with 250 mg/kg of APAP. After APAP treatment, Gab1 CKO mice had significantly higher mortality and elevated serum alanine aminotransferase levels compared to control mice. Gab1 CKO mice had increased hepatocyte death and increased serum levels of high mobility group box 1, a marker of hepatocyte necrosis. In addition, Gab1 CKO mice had reduced hepatocyte proliferation. The enhanced hepatotoxicity in Gab1 CKO mice was associated with increased activation of stress‐related c‐Jun N‐terminal kinase (JNK) and reduced activation of extracellular signal‐regulated kinase and AKT. Furthermore, Gab1 CKO mice showed enhanced mitochondrial translocation of JNK accompanied by an increase in the release of mitochondrial enzymes into the cytosol, which is indicative of increased mitochondrial dysfunction and subsequent nuclear DNA fragmentation. Finally, in vitro experiments showed that Gab1‐deficient hepatocytes were more susceptible to APAP‐induced mitochondrial dysfunction and cell death, suggesting that hepatocyte Gab1 is a direct target of APAP‐induced hepatotoxicity. Conclusion: Our current data demonstrate that hepatocyte Gab1 plays a critical role in controlling the balance between hepatocyte death and compensatory hepatocyte proliferation during APAP‐induced liver injury. (H epatology 2016;63:1340–1355)
Biological Regulatory Network (BRN) Analysis and Molecular Docking Simulations to Probe the Modulation of IP3R Mediated Ca2+ Signaling in Cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Inositol trisphosphate receptor (IP3R) mediated Ca+2 signaling is essential in determining the cell fate by regulating numerous cellular processes, including cell division and cell death. Despite extensive studies about the characterization of IP3R in cancer, the underlying molecular mechanism initiating the cell proliferation and apoptosis remained enigmatic. Moreover, in cancer, the modulation of IP3R in downstream signaling pathways, which control oncogenesis and cancer progression, is not well characterized. Here, we constructed a biological regulatory network (BRN), and describe the remodeling of IP3R mediated Ca2+ signaling as a central key that controls the cellular processes in cancer. Moreover, we summarize how the inhibition of IP3R affects the deregulated cell proliferation and cell death in cancer cells and results in the initiation of pro-survival responses in resistance of cell death in normal cells. Further, we also investigated the role of stereo-specificity of IP3 molecule and its analogs in binding with the IP3 receptor. Molecular docking simulations showed that the hydroxyl group at R6 position along with the phosphate group at R5 position in ‘R’ conformation is more favorable for IP3 interactions. Additionally, Arg-266 and Arg-510 showed π–π and hydrogen bond interactions and Ser-278 forms hydrogen bond interactions with the IP3 binding site. Thus, they are identified as crucial for the binding of antagonists.
Can Artificial Intelligence (AI) Manage Behavioural Biases Among Financial Planners?

Field: Computer Science (Physical Sciences)

The main novelty of this paper is proposing artificial intelligence (AI) to manage behavioural biases in the financial decision-making process. An empirical study by Kahneman and Tversky identifies the evidence of behavioural biases in the investment decision-making process: a reversal of an established tenet in traditional finance. Financial planners are vulnerable to behavioural biases and are therefore unable to provide optimal investment solutions for their clients. Identifying the limitations of current practice, this research attempts to address how AI can help financial planners in subduing their behavioural biases and proposes the adoption of AI in financial planning services to circumvent behavioural biases. In recent years, AI has attained significant efficacy and has proven to be efficacious through supervised and unsupervised learning. Applying these AI techniques in mitigating behavioural biases, this study confirms that the backpropagation within the neural network and deep reinforcement learning can help overcome confirmation and hindsight biases.
Simultaneous Search

Field: Economics, Econometrics and Finance (Social Sciences)

We introduce and solve a new class of "downward-recursive" static portfolio choice problems. An individual simultaneously chooses among ranked stochastic options, and each choice is costly. In the motivational application, just one may be exercised from those that succeed. This often emerges in practice, such as when a student applies to many colleges or when a firm simultaneously tries several technologies. Copyright The Econometric Society 2006.
Design, Synthesis, and Antitumor Activity of Novel 5-Pyridyl-1,3,4-oxadiazole Derivatives against the Breast Cancer Cell Line MCF-7

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Various 1,3,4-oxadiazole-2-thiol derivatives have considerable potential in the field of antitumor activity. On the basis of the structure of the highly active reported oxadiazole analogues, 36 novel compounds were designed. Their molecular transport properties were predicted using a computer-aided program, and they were then synthesized and tested for anticancer activity against the breast cancer cell line MCF-7. Most of the tested compounds showed excellent to potent cytotoxic activity. Docking studies were carried out to examine the possibilities of the target compounds to become lead compounds in the future after more biological investigations. Compounds 18 and 22 were more active than the reference drug with IC₅₀ values of 0.010 µM and 0.012 µM, respectively, and binding energy scores of -10.32 and -10.25, respectively.
Research on intelligent recognition method of software vulnerability severity based on event extraction

Field: Computer Science (Physical Sciences)

Abstract The number of vulnerability reports is rapidly increasing, and relying on human resources for vulnerability analysis will become more difficult. In addition, the current vulnerability report research is mainly based on general vulnerability disclosure (CVE) or other foreign open source projects, and there are few researches on Chinese vulnerability reports. With the development of deep learning, the research on event extraction has also been greatly developed. In order to contribute to the vulnerability analysis of Chinese vulnerability report, this paper adopts the method of event extraction to automatically mine the vulnerability report of the National Information security Vulnerability Sharing platform (CNVD). A new vulnerability analysis method is proposed, that is, the severity level of vulnerability report is evaluated by the vulnerability description information and the event information. At the same time, a convolutional neural network method named EICNN is proposed to realize this new vulnerability analysis method by integrating event information. An application that obtains the vulnerability reporting event information and evaluates the vulnerability severity at the end.
New Diagnostic-Based Systematic Classification for Skier's Thumb Injuries: A Revision That is Needed

Field: Medicine (Health Sciences)

Abstract Background Acute injuries to the ulnar collateral ligament (UCL) of the first metacarpophalangeal joint (MCPj), commonly referred to as Skier’s thumb injuries, can be further categorized into different types based on bone lesions and joint instability. However, none of the existing classifications encompasses all types and combinations of injuries. A unified classification system that provides direct treatment recommendations for each type is required, particularly for cases with no clear indications. Aims To develop a new classification system for acute UCL injuries of the first MCPj that comprehensively defines all possible combinations and types of injuries and facilitates treatment decision-making for each specific type in daily clinical practice. Methods The retrospective study included patients with acute UCL lesions who underwent conservative or operative treatment at our clinic between 2018 and 2023. This classification addresses ligamentous or osseous lesions, fracture fragment size and dislocation, ligament configuration (e.g. Stener lesions), and joint stability. Correlated radiography, ultrasonography, MRI, and intraoperative findings were used to define all combinations and variants of skier`s thumb injuries. Pre-therapeutic joint stability was characterized according to the criteria established in the literature. Dislocation criteria for bone lesions were defined in a preliminary observer trial. The classification was applied by three hand surgeons with different training levels. Treatment applied and a 3-months follow-up was documented. Results In 213 patients with acute UCL tears, the new classification was consistently applied, and the treatment derived was largely aligned with the recommendations in the literature for both absolute and relative indications for splint or operative therapy. The vast majority of the patients were stable after 3 months. Conclusion This new classification is the first to combine the clinical and radiological aspects of skier`s thumb injuries into one classification and encompasses all variants. It is comprehensive, can be easily applied retrospectively, and provides clear treatment recommendations in most cases.
Phaseolus vulgaris L. INCBN_00401_20250319

Field: Agricultural and Biological Sciences (Life Sciences)

Plant Genetic Resource.
Taxonomy: Phaseolus vulgaris L.
Common name(s): Common bean
Conserved by: Raissa Falaschi, Italy
Local sample unique identifier: INCBN_00401_20250319
Method of creation: Acquisition
Date: 2025-03-19
Historical: No
Biological status: Breeding/research material
MLS status: SMTA transfer
The Effect of Recovery Duration on Technical Proficiency during Small Sided Games of Football

Field: Medicine (Health Sciences)

The aim of this study was to determine the effect of increasing the duration of the recovery periods separating serial bouts of small sided games (SSG) of football on technical skills (TS). Twelve semi-professional footballers (mean ± SD; age 21 ± 3 years; VO2peak 64 ± 7 mL∙min∙kg−1; playing experience 15 ± 3 years) completed two SSG sessions, consisting of 3 vs. 3 players and 6 bouts of 2 min, separated by either 30 s recovery (REC-30) or 120 s recovery (REC-120). Sixteen TS, including passing, possession, and defensive related variables, and exercise intensity (heart rate, rating of perceived exertion, time motion descriptors) during the bouts were measured. Repeated measures ANOVA were used to determine differences between-conditions, for TS. The number of successful tackles was significantly higher, and the average time each team maintained possession was significantly lower in REC-120 compared to REC-30. There were no significant differences for all other TS variables, or exercise intensity measures between REC-30 and REC-120. Overall, a four-fold increase in the duration of recovery separating SSG bouts did not alter the technical skill execution of players. The experience and skill level of the players, combined with an apparent regulation of effort through pacing, may have assisted in the maintenance of technical skill execution.
Genetic characterization of cultivated varieties of European chestnut (<em>Castanea sativa</em> Mill.) in southern Switzerland. (II) Genetic inventory based on enzyme gene markers

Field: Agricultural and Biological Sciences (Life Sciences)

A set of 175 chestnut trees was genotyped at 12 polymorphic isoenzyme gene loci. These trees belong to a total of 13 presumed varieties with partially unknown origin. Only those varieties were studied, which consist of a minimum of five different individuals. Among a total of 175 trees, 110 different 12-locus genotypes were observed.<br />The genetic inventory of this material suggests that varieties with wide spatial distribution and discontinous occurrence reveal largest diversities. Within certain varieties, genetic similarity is evident while others consist of individuals which are genetically very different. In several cases, genetic similarities seem to correspond to morphological classifications. Genotyping helps to overcome problems in the identification of individual trees or varieties and may allow the determination of their origin. Results are compared with corresponding data from Italian varieties.
Three new species of Tubificinae, Oligochaeta, from two plateau lakes in Southwest China

Field: Agricultural and Biological Sciences (Life Sciences)

Cui, Yongde, Wang, Hongzhu (2009): Three new species of Tubificinae, Oligochaeta, from two plateau lakes in Southwest China. Zootaxa 2143: 45-54, DOI: 10.5281/zenodo.188610
An Epidemiological, Diagnostic and Therapeutic Study of Giardialamblia in Anbar Province – Iraq

Field: Medicine (Health Sciences)

This study was carried out to investigate the epidemiology of Giardia lamblia parasites in patients who visited some of the hospitals in Anbar province, which included (Fallujah Teaching Hospital, Ramadi Teaching Hospital, Ramadi Teaching Hospital for Women and Children and Hit Hospital ) during by examining 864 stool samples in a direct examination method, The results revealed the infection rate was 41.7 % and the percentage of infection among males 47.8% is higher than that of females 35.4% with significant differences (p≤0.05). The age groups (1-9) years recorded the highest ratesm,55.4% and the lowest rate 13.6% in the age group (40-49) years. The highest rate of infection was 62.5% during the month of June, while the month of October was the lowest rate 5% and significant differences. The incidence rate in rural areas was 50.6% higher than in the urban areas 32.5%. The study also included the effect of Teucrium polium L. on the parasite in the culture media HSP-1, the concentrations of 0.5-3 mg / mL significantly affected Giardia, it was noted whenever the greater the concentration, the greater the effect during different treatment periods (1-4) days, as the highest concentration 3 mg/ml killed all Giardia parasites on the fourth day of treatment.
In vitro immunosuppressive activities of recently developed anthracycline cytostatics.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The effects of a series of seven anthracycline cytostatics on various human leukocyte functions, namely the production of Migration Inhibition Factor (MIF) by lymphocytes and the production of chemiluminescence by activated polymorphonuclear leukocytes (PMNs), as well as on classical and alternative pathways of activation of human complement were investigated. In addition, lipophilic and electrochemical properties of the compounds were determined, by measuring their High Performance Liquid Chromatography (HPLC) capacity ratio (k') and half-wave reduction potential (E1/2). The antitumor agents under investigation suppressed, in most cases, lymphocyte and PMN functions, whereas complement activity remained unaffected. The extent of suppressive effects showed a good correlation with the lipophilicity of the compounds, while no correlation with reduction potentials was found.
A Case of Cerebro-Spinal Meningitis

Field: Medicine (Health Sciences)

Considering the amount of attention which has lately been given to cerebro-spinal meningitis, and the obscurity which still hangs over the disease, I think the following case, which occurred in the Asylum at Carlisle, in April, 1867, worthy of record. It was a sporadic case, but its accessories and accompaniments invest it with some of the interest of those epidemics of the disease which have lately occurred:— T. C. had been a patient in the asylum for five years; he had laboured under melancholia with periodic exacerbations and suicidal tendencies. On the whole he enjoyed very fair bodily heath, except when he became somewhat weak at times from refusal of food. But he generally got over this in a few days. He had most obstinate and severe psoriasis over shoulders, arms, hands, and legs.
Economic and Statistical Analysis of Development of Non-state Retirement Insurance System in Ukraine

Field: Economics, Econometrics and Finance (Social Sciences)

The analysis of the development of nonstate retirement insurance system for the period 2005-2012 is done in the article.Performed computations indicate a significant decrease in the development pace of the NSPF after 2008, which manifests both in absolute and relative indices.It is found that one of the important causes of development pace retardation is reduction of rate of return of NSPF.Close correlation between the net value of pension assets unit (NVU -index that reflects NSPF returns) and their size using an analytical grouping was proved.Correlation and regression analysis of the impact of selected factors on NVU of non-state pension funds (NSPF) of Ukraine was conducted.The author made a comparative analysis of quantitative and qualitative indices of NSPFs included in Top 10 and other market participants, which showed the superiority of NSPFs over all analyzed parameters.The main variation indices of investment activity of NSPF of Ukraine during 2008-2012 are determined.The main problems of further development of non-state retirement insurance system in Ukraine are outlined.