jimnoneill/paper-to-field-training huggingface dataset:
Calcium depletion blocks proteolytic cleavages of plasma protein precursors which occur at the Golgi and/or trans-Golgi network. Possible involvement of Ca(2+)-dependent Golgi endoproteases.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The effects of calcium depletion on the proteolytic cleavage and secretion of plasma protein precursors were investigated in primary cultured rat hepatocytes and HepG2 cells. When the cells were incubated with A23187, the calcium-specific ionophore, in a medium lacking CaCl2, precursors of serum albumin and the third and fourth components of complement, C3 and C4, respectively, were found to be released into the medium. The addition of ionomycin or EGTA to the medium inhibited the processing of pro-C3 as well. Blocking the secretory pathway either at the mixed endoplasmic reticulum/Golgi in the presence of brefeldin A or at the endoplasmic reticulum/tubular-vesicular structure at a reduced temperature caused accumulation of pro-C3 within hepatocytes or HepG2 cells, indicating that the cleavage of the precursor occurs at a later stage of the secretory pathway. Once the blockade was released by incubating the cells either in the brefeldin A-free medium or at 37 degrees C, the secretion of plasma proteins resumed, irrespective of the presence of A23187. However, the processing of pro-C3 was almost completely inhibited in the presence of A23187, with only the precursor being released into the medium, implying that a decline in Ca2+ levels within the cell modulates the activity of a Golgi endoprotease responsible for the cleavage of pro-C3. When incubated with isolated Golgi membranes, pro-C3 secreted from Ca(2+)-depleted cells was cleaved in vitro into their subunits in the presence of Ca2+ but not in its absence, pointing to the involvement of a Ca(2+)-dependent Golgi endoprotease in the processing of pro-C3. These results collectively suggest that calcium depletion blocks the proteolytic cleavages of plasma protein precursors presumably by exhausting a Ca2+ pool available to the Ca(2+)-dependent processing enzyme(s) located at the Golgi and/or trans-Golgi network.
Central Neck Ultrasound: A Single-Center Experience of Its Diagnostic Accuracy After Thyroidectomy in Patients with Thyroid Cancer

Field: Medicine (Health Sciences)

Background: Ultrasonography (US) plays a crucial role in managing recurrent and persistent tumors in thyroid cancer, the most common endocrine malignancy, affecting approximately half a million people worldwide annually. Objectives: This study investigates the use of local US criteria to differentiate between post-operative changes (such as seroma, granulation tissue, and surgical material), residual normal thyroid tissue, tumor remnants, metastatic adenopathy, and nonspecific lesions after thyroidectomy in patients with thyroid cancer. Methods: A total of 177 thyroid cancer patients (76.3% female) were referred to the US and followed up for a final histopathological diagnosis. US results were compared with needle biopsy findings. Results: Histopathology confirmed 95.8% (113/118) of the US-identified lesions as malignant and 78.6% (44/56) as benign. In total, 125 lesions were malignant, while 49 were benign. The US had a sensitivity of 90.4%, specificity of 89.8%, diagnostic accuracy of 90.23%, positive predictive value (PPV) of 95.76%, and negative predictive value (NPV) of 78.57%. The positive and negative likelihood ratios were 8.9 and 0.11, respectively. Vascular patterns had the highest sensitivity, specificity, and accuracy among the parameters studied, but shape and echogenicity were unsatisfactory. Conclusions: Our results demonstrated that the US has around 90% sensitivity and specificity in identifying malignancy in postoperative thyroid cancer patients. These findings suggest that neck US is an effective technique for diagnosing thyroid bed lesions.
Specification for Seamless and Welded Austenitic Stainless Steel Feedwater Heater Tubes

Field: Engineering (Physical Sciences)

This specification covers standard requirements for welded austenitic stainless steel feedforward heater tubes including those bent, if specified, into the form of U-tubes for application in tubular feed-water heaters. All finished straight tubing or straight tubing ready for U-bending shall be furnished in the solution-annealed condition. The steel shall conform to the required chemical composition for carbon, phosphorus, chromium, molybdenum, nitrogen, and copper. The material shall also conform to tensile properties such as tensile strength, yield strength, and elongation. The steel shall undergo mechanical tests such as tension test, hardness test, reverse bend test, flattening test, flange test, pressure test, hydrostatic test, and air underwater test. Nondestructive test (electric test) shall be performed and corrosion resisting properties shall be determined for each sample tube.
[Adenovirus pneumonia with a fatal outcome in adults].

Field: Medicine (Health Sciences)

Adenovirus pneumonia causes diagnostic and therapeutic problems for clinicians. The clinical introduction of PCR methods for the diagnosis of viral infections allow the clinicians to elaborate and timely use effective management tactics in patients with adenoviral pneumonia and to prevent their death. It is necessary to design etiotropic therapy agents and to introduce the specific prevention of adenovirus infection in risk groups.
Intellectual Property Management System: An Organizational Perspective

Field: Business, Management and Accounting (Social Sciences)

In today’s knowledge driven economy intellectual property (IP), intellectual capital, and organizational capabilities are crucial for enhancing business performance and economic growth. Intellectual property rights as a key intellectual asset of the organization empowers innovators to collect full value of their invention. It has now become a prerequisite for organizations to develop expertise and capability not only to create intellectual property through R&D, but also to manage it and give it due weightage in strategic decision making. The paper evaluates the role of Intellectual Property Management System (IPMS) in building organizational capabilities to achieve sustainable competitive advantage. The paper also discusses case of an Indian academic institute, where IPMS helped in building organizational capabilities.
Microbiological Profile of Orthopaedic Implant Associated Infections: A Prospective Study

Field: Medicine (Health Sciences)

Introduction: The incidence of orthopaedic implantation and implantation associated infections were correspondingly increasing among the elderly and trauma patients. The resistance among the pathogens pose a unique challenge to the clinicians in the management of the infection. Extended-Spectrum Beta-Lactamase (ESBL), AmpC beta-lactamases (AmpC), Metallo Beta-Lactamases (MBL) and Methicillin-Resistant Staphylococcus aureus (MRSA) producing bacterial pathogens are responsible for a high rate of relapsing infections and outbreaks of nosocomial infections. Aim: To focus on accounting the incidence of ESBL, AmpC, MBL and MRSA and its antibiogram for effective management of implant associated infection. Materials and Methods: The present study was a prospective observational study which was conducted using various samples like pus, wound swab, serous discharge. These samples were collected under aseptic precautions in sterile containers for the period of one year (February 2015-February 2016). A total of 200 samples were inoculated on Blood agar and McConkey agar and identified. The isolates were tested for detection of ESBL, AmpC, MBL and MRSA as per standard protocol. The statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) software version 20.0 Chicago, USA. Results: Most commonly used implants were intramedullary interlocking nail 138 (65.7%) followed by dynamic compression plates 23 (11.0%) and anatomical plates 18 (8.6%). Of the total of 200 samples, 190 (95%) samples yielded monomicrobial isolates and 10 (5%) samples yielded polymicrobial isolate. gram negative isolates 108 (51.4%) were marginally higher than gram positive isolates 102 (48.6%). The predominant isolate was S. aureus 81 (38.5%) followed by Klebsiella spp. 28 (13.3%) and Pseudomonas aeruginosa 21 (10.0%). In gram negative isolates, 76 (70.4%) were ESBL and/or AmpC producers. Of which, 48 (44.4%) were ESBL and AmpC co-producers. There were no MBL producing isolates. In gram positive isolates, majority were S. aureus 81 (79.4%) followed by Coagulase-negative Staphylococcus 21 (20.6%). Out of 81 S. aureus isolates, 46 (56.8%) were MRSA. Out of 21 CoNS, majority 17 (81%) isolates were methicillin-resistant. Implant failures were observed in 28 (14%) cases. Out of 28, majority 12 (42.8%) of the implant failures were MRSA. Conclusion: High rates of ESBL, AmpC and MRSA infections associated with implant surgeries indicate the necessity to formulate antibiotic policies and control measures. ESBL and AmpC producing strains were found to show higher rates of resistance to the various class of antibiotics when compared to non-ESBL and non-AmpC producers. MRSA isolates were found to show higher rates of resistance to various classes of antibiotics when compared to MSSA.
A Light Model for Super-Resolution of Remote Sensing Images

Field: Computer Science (Physical Sciences)

Abstract Remote sensing image super-resolution is an important research topic, which helps to improve the quality of remote sensing images. However, because remote sensing images are usually quite large while the satellite equipment often have low computing capacity and small memory, it is appealing to develop lightweight and fast models to perform the super-resolution task for the remote sensing images. In this paper, we empirically study the effectiveness of conventional super-resolution approaches for remote sensing images, and propose an effective way to reduce the model parameters and computational cost. Specifically, motivated by Res2Net, we design a new multi-scale hierarchy residual block to replace the ResBlock in EDSR to provide a more diverse receptive field for each residual block. The proposed modified method has fewer parameters and faster speed compared with the original EDSR. Moreover, we also build two benchmark super-resolution datasets (i.e., DOTA-SR and LEVIR-SR) from DOTA and LEVIR-CD, respectively, for experimental evaluation. We perform experiments on the two datasets, and results show that our method is light and have comparable performance over the existing super-resolution baselines.
Early detection of isolated pleural metastasis from carcinoma pyriform fossa: Can it be steered away from doom?

Field: Medicine (Health Sciences)

Isolated pleural metastasis from carcinoma of the pyriform fossa is a rare phenomenon. Literature search revealed pleural metastasis from head-and-neck cancer is in itself rare and carries a grave prognosis. Isolated pleural metastasis with local control in the primary and regional site with no other documented distant metastatic disease is again rarely encountered. We report this case as detection of pleural-based metastasis early in the course of disease and intervention can result in better outcome.
NO-Bound Myoglobin:  Structural Diversity and Dynamics of the NO Ligand

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

We used femtosecond infrared polarization spectroscopy and density functional theory in a study on the key signaling molecule nitric oxide (NO) bound to myoglobin. Our results show that after photolysis, a substantial fraction of NO recombines within the first few picoseconds. We discovered that the diatomic ligand is severely tilted in the protein and present evidence that the Fe-NO moiety can sample a wide range of off-axis tilting and bending conformations.
Women’s Orgasm Gap as a Function of Precarious Manhood

Field: Psychology (Social Sciences)

The disparity in frequency of orgasms between men and heterosexual women has been linked qualitatively to women purposefully not communicating their sexual needs in order to preserve their partner’s masculinity. In two studies I experimentally evaluated this relationship, sampling heterosexual undergraduate women. In study 1 (N = 246) I demonstrated that women who imagined not having an orgasm rated an imaginary partner as more insecure in his manhood, relative to women who imagined having an orgasm or going on a dinner date. These perceptions of insecurity mediated the relationship between not having an orgasm and reporting anxiety about hurting their partner’s ego. Additionally, this relationship was moderated by the degree to which women believe manhood must be earned and can be lost through sex. In study 2 (N = 282) I predicted women who imagine a partner who is insecure in his masculinity, relative to imagining a secure partner or a control condition, will be less willing to provide open and honest sexual communication, and this relationship would be mediated by anxiety about their partner’s ego, a relationship moderated by endorsement of precarious manhood beliefs. My analyses did not reveal support for these hypotheses. Implications, limitations and future directions are discussed.
Navigation Techniques and Algorithms for Mobile Robots and Automated Guided Vehicles

Field: Computer Science (Physical Sciences)

Mobile robots are self-contained devices that can navigate and move around their surroundings. They observe their environment and create maps using different sensors such as lidar, Global Positioning System (GPS), and cameras. Automated Guided Vehicles (AGVs) are vehicles that can move independently utilizing different approaches such as underground cables, laser scanners, or GPS systems. This research investigates several navigation methodologies and algorithms used in AGVs and mobile robots. It focusses on the advantages of integrating lidar technology with other sensors as well as how it is used in local navigation techniques. We look at two motion planning techniques for obstacle avoidance: the Artificial Potential Field (APF) approach and the Vector Field Histogram (VFH) algorithm. Two effective techniques for finding the best routes are discussed: the A* algorithm and Dijkstra's algorithm. The various AGV types and their navigation systems (such as wired, guide, laser, vision-based, and gyro-based) are also examined in the study. Neural networks and fuzzy logic are investigated as AGV control techniques, with line following and obstacle avoidance as examples of their use. The study emphasizes how crucial precise and dependable navigation systems are to the effective and secure operation of mobile robots and AGVs.
Topology-Based Character Recognition Method For Coin Date Detection

Field: Computer Science (Physical Sciences)

For recognizing coins, the graved release date is important information to identify precisely its monetary type. However, reading characters in coins meets much more obstacles than traditional character recognition tasks in the other fields, such as reading scanned documents or license plates. To address this challenging issue in a numismatic context, we propose a training-free approach dedicated to detection and recognition of the release date of the coin. In the first step, the date zone is detected by comparing histogram features; in the second step, a topology-based algorithm is introduced to recognize coin numbers with various font types represented by binary gradient map. Our method obtained a recognition rate of 92% on synthetic data and of 44% on real noised data.
The Impact of Terminal Illness on the Spouse

Field: Nursing (Health Sciences)

This descriptive study explores the responses, concerns and problems of the hospitalized, terminally ill, cancer patient's spouse. The findings of the study suggest that spouses experience a deterioration in their health, disturbed thought processes, and a variety of emotional responses when confronted with the impending death of a husband / wife from cancer. Spouses are concerned about the physical symptoms, such as pain, experienced by the patient and their inability to communicate with him or her. The spouses’ problems centre on changes or anticipated changes in their lifestyle. An important finding of the study was the identification of a group of spouses who appear to be at risk. These spouses reported a high incidence of physical symptoms in relation to their own health, a high incidence of emotional responses, and numerous concerns.
Phase noise in self-injection-locked oscillators - Theory and experiment

Field: Engineering (Physical Sciences)

Phase-noise analysis of the self-injection-locked oscillator is presented in this paper. The analysis is developed for different oscillator models and arbitrary self-injection feedback loops. The results are illustrated with specific cases of simple time-delay cable and a high-Q factor resonator. It is shown that the behavior of the phase noise is similar to an oscillator locked to an external low phase-noise source. The output phase noise can be reduced at the noise offset frequency near the carrier frequency, and returning to the free-running oscillator noise far from the carrier frequency for certain stable feedback delay ranges. The phase-noise reduction is affected by the self-injection signal strength and feedback transfer function for different oscillator equivalent-circuit models. The theory is verified by using a self-injection-locked GaAs MESFET oscillator operating at the X-band with delay cable loops. The self-injection-locked technique may be used to improve the phase noise of the existing oscillators.
Controlling Pythium in Ginger: Phase 2

Field: Mathematics (Physical Sciences)

We explore the possibility of controlling the wake and drag of a spherical object independently of each other, using radial distributions of permeability in the Brinkman-Stokes formalism. By discretizing a graded-permeability shell into discrete, macroscopically homogeneous layers, we are able to sample the entire functional space of spherically-symmetric permeabilities and observe quick convergence to a certain manifold in the wake-drag coordinates. Monte Carlo samplings with 10^{4}-10^{5} points have become possible thanks to our new algorithm, which is based on exact analytical solutions for the Stokes flow through an arbitrary multilayer porous sphere. The algorithm is not restricted to the Brinkman-Stokes equation and can be modified to account for other types of scattering problems for spherically-symmetric systems with arbitrary radial complexity. Our main practical finding for Stokes flow is that it is possible to reduce a certain measure of wake of a spherical object without any energy penalty and without active (power-consuming) force generation.
Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa

Field: Immunology and Microbiology (Life Sciences)

Opportunistic infections are often polymicrobial. Two of the most important bacterial opportunistic pathogens of humans, Pseudomonas aeruginosa and Staphylococcus aureus , frequently are coisolated from infections of catheters, endotracheal tubes, skin, eyes, and the respiratory tract, including the airways of people with cystic fibrosis (CF). Here, we show that suppression of S. aureus respiration by a P. aeruginosa exoproduct, 4-hydroxy-2-heptylquinoline- N -oxide (HQNO), protects S. aureus during coculture from killing by commonly used aminoglycoside antibiotics such as tobramycin. Furthermore, prolonged growth of S. aureus with either P. aeruginosa or with physiological concentrations of pure HQNO selects for typical S. aureus small-colony variants (SCVs), well known for stable aminoglycoside resistance and persistence in chronic infections, including those found in CF. We detected HQNO in the sputum of CF patients infected with P. aeruginosa , but not in uninfected patients, suggesting that this HQNO-mediated interspecies interaction occurs in CF airways. Thus, in all coinfections with P. aeruginosa , S. aureus may be underappreciated as a pathogen because of the formation of antibiotic-resistant and difficult to detect small-colony variants. Interspecies microbial interactions, analogous to those mediated by HQNO, commonly may alter not only the course of disease and the response to therapy, but also the population structure of bacterial communities that promote the health of host animals, plants, and ecosystems.
Differential cross sections for coherent and incoherent neutral-pion photoproduction from calcium

Field: Physics and Astronomy (Physical Sciences)

Differential and absolute cross sections for the coherent reaction $^{40}\mathrm{Ca}$(\ensuremath{\gamma},${\ensuremath{\pi}}^{0}$${)}^{40}$Ca g.s., as well as for the incoherent reaction $^{40}\mathrm{Ca}$(\ensuremath{\gamma},${\mathrm{\ensuremath{\pi}}}^{0}$${)}^{40}$Ca(g.s.), have been measured with monochromatic photons in the threshold region (${E}_{\ensuremath{\gamma}}$=157--169 MeV). The differential cross section for the coherent process exhibits a diffraction minimum due to the nuclear mass form factor while the incoherent cross section is rather structureless. The cross sections are in good agreement with recent distorted-wave impulse-approximation calculations.
Identification of a novel causative gene for dilated cardiomyopathy requiring heart transplantation and elucidation of the mechanism of protein homeostasis in cardiomyocytes

Field: Medicine (Health Sciences)

Heart failure is an increasingly serious public health issue, affecting more than 37.7 million individuals worldwide. The prognosis of patients with heart failure is still poor, with 5-year survival rates of 45.5%, regardless of advanced medical therapy. Dilated cardiomyopathy (DCM) is a major cause of end-stage heart failure requiring heart transplantation. Identifying a novel causative gene for DCM and elucidating its molecular mechanisms could lead to new insight into the pathogenesis of heart failure. Using the combination approach of whole-exome sequencing and transcriptome analysis of failing hearts, we identified the BAG cochaperone 5 (BAG5) as a novel causative gene for juvenile-onset DCM requiring heart transplantation (Hakui et al. Science Translational Medicine. 2022). All the BAG5 homozygous truncating mutations disrupted the C-terminal functional BAG domain and disabled the protein folding activity of a molecular chaperone heat shock cognate 71 kDa protein. Immunocytochemical analysis revealed that BAG5 localized to the junctional membrane complex (JMC), a critical microdomain for calcium-handling in the heart. Moreover, cardiomyocytes isolated from BAG5 mutant knock-in mice showed specifically decreased JMC protein levels under cardiac stress, disrupted JMC structure, and calcium-handling abnormalities. Our findings highlight the involvement of JMC protein homeostasis in the pathogenesis of heart failure.
Pengaruh Pemberian Insentif Dan Motivasi Terhadap Kinerja Karyawan Pada Bengkel Sintong Teknik Perkasa Palembang

Field: Business, Management and Accounting (Social Sciences)

This study aimed to examine the effect of incentives and motivation to \nemployees performance at Sintong Perkasa Engineering Workshop Palembang. \nThe sample used in this study is 42 employees. Hypothesis testing using Multiple \nLinear Regression Analysis using SPSS 16.0. The results of this study stated that \n1) Incentives positive and significant effect on employee performance .2) \nMotivation give negative and not significant effect on employee performance, 3) \nIncentives and Motivation jointly affect the performance of employees. Based on \nthe adjusted R-square of 0.198 means that 19.8% variable employee performance \ncan be explained by the variable incentives and motivation, while the remaining \n80.2% is influenced by other variables that are not investigated in this study.