jimnoneill/paper-to-field-training huggingface dataset:
A well-differentiated liposarcoma of the prevertebral space: A case report

Field: Medicine (Health Sciences)

Abstract

Liposarcoma is common in adults; however, it very rarely occurs in the retropharyngeal space, and to date, no cases of liposarcoma in the prevertebral space have been reported. A 78-year-old man presented at the Otolaryngology Department with a 1-month history of dyspnea and dysphonia. Magnetic resonance imaging of the neck reveled a retropharyngeal mass extending from the superior margin of the axis to the level of the 7thcervical vertebra. A computed tomography scan of the patient’s neck uncovered the relationship between the mass and its’ surrounding structures. Based on the above examinations, a diagnosis of retropharyngeal liposarcoma was made initially. The patient underwent transoral surgical excision with the assistance of a nasal endoscope. During surgery, the tumor was located in the prevertebral space. Combined with pathology and immunohistochemistry examinations, the diagnosis was modified to well-differentiated liposarcoma of the prevertebral space. At the 1-year follow-up, the patient was well and there was no evidence of recurrence. The long-term outcomes are not yet known. Liposarcoma of the prevertebral space may sometimes be misdiagnosed as retropharyngeal liposarcoma; however, in our view, it is not necessary to focus on differentiating between enormous retropharyngeal and prevertebral tumors. In relation to the short-term outcome, complete excision using the transoral approach with the aid of nasal endoscope may present a better choice than the cervical approach in treating these tumors, especially in old people.
Pengaruh Kepribadian Pendeta Terhadap Minat Kebaktian Minggu Pada Jemaat Di Gereja Pantekosta Isa Al Masih Medan Helvetia

Field: Social Sciences (Social Sciences)

The purpose of this study was to see how the influence of the personality of the pastor on the interest in Sunday services in the congregation at the Pentecostal Church of Isa Al Masih Medan Helvetia. This type of research is qualitative research with the research population being some of the congregation and pastors at the Pentecostal Church of Isa Al Masih Medan Helvetia. Where in this study using qualitative descriptive. Data collection in this study used observation and interview methods. The interview technique was carried out in a structured manner using the interview method. The analysis of the research data was descriptive. After conducting the research, the results of this study indicate that the personality of the pastor greatly influences the interest of the congregation in the Sunday service at the Isa Al Masih Pentecostal Church in Medan Helvetia. The personality of the pastor in this church shows that his personality greatly influences the interest of the congregation in the Sunday service. The congregation who are experiencing struggles begin to be approached by the pastor and the church will conduct Bible study for the congregation and this is also used by the pastor to approach the congregation.
Clinical-effectiveness of self-management interventions in chronic obstructive pulmonary disease: An overview of reviews

Field: Health Professions (Health Sciences)

Self-management (SM) is defined as the provision of interventions to increase patients’ skills and confidence, empowering the individual to take an active part in their disease management. There is uncertainty regarding the optimal format and the short- and long-term benefits of chronic obstructive pulmonary disease (COPD) SM interventions in adults. Therefore, a high-quality overview of reviews was updated to examine their clinical effectiveness. Sixteen reviews were identified, interventions were broadly classified as education or action plans, complex interventions with an SM focus, pulmonary rehabilitation (PR), telehealth and outreach nursing. Systematic review and meta-analysis quality and the risk of bias of underlying primary studies were assessed. Strong evidence was found that PR is associated with significant improvements in health-related quality of life (HRQoL). Limited to moderate evidence for complex interventions (SM focus) with limited evidence for education, action plans, telehealth interventions and outreach nursing for HRQoL was found. There was strong evidence that education is associated with a significant reduction in COPD-related hospital admissions, moderate to strong evidence that telehealth interventions and moderate evidence that complex interventions (SM focus) are associated with reduced health care utilization. These findings from a large body of evidence suggesting that SM, through education or as a component of PR, confers significant health gains in people with COPD in terms of HRQoL. SM supported by telehealth confers significant reductions in healthcare utilization, including hospitalization and emergency department visits.
Open Government Data: Usage trends and metadata quality

Field: Computer Science (Physical Sciences)

Open Government Data (OGD) have the potential to support social and economic progress. However, this potential can be frustrated if these data remain unused. Although the literature suggests that OGD data sets’ metadata quality is one of the main factors affecting their use, to the best of our knowledge, no quantitative study provided evidence of this relationship. Considering about 400,000 data sets of 28 national, municipal and international OGD portals, we have programmatically analysed their usage, their metadata quality and the relationship between the two. Our analysis has highlighted three main findings. First, regardless of their size, the software platform adopted, and their administrative and territorial coverage, most OGD data sets are underutilised. Second, OGD portals pay varying attention to the quality of their data sets’ metadata. Third, we did not find clear evidence that data sets’ usage is positively correlated to better metadata publishing practices. Finally, we have considered other factors, such as data sets’ category, and some demographic characteristics of the OGD portals, and analysed their relationship with data sets’ usage, obtaining partially affirmative answers.
A Bioengineered Gene Therapy System with Potential to Heal War Wounds

Field: Medicine (Health Sciences)

Abstract : Wound healing is a controlled coordinated response to tissue injury leading to scar tissue formation. It involves complex interactions between cell types, matrix and soluble mediators. When one or more of these components is disrupted, wound healing is delayed or even halted. There has been some success with topical application of growth factors to improve healing in the face of sepsis and infection. However the effects have been modest. A major limitation of topical application of growth factors is that they are destroyed rapidly by tissue proteases. The gene therapy approach we propose will have the advantage of continually producing growth factors within the wound to constantly replenish tissue levels. Our approach also allows the production of multiple growth factors to maximize potential benefit.
Effect of albendazole in experimental toxocariasis of mice

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Fifty-five mice were each infected with 800 embryonated eggs of Toxocara cards. Beginning on the second day of the infection, one group received a single 9 mg dose of albendazole every 24 hours for an eight-day period while a second group received 3 mg of albendazole every eight hours for the same period. On the tenth day of infection, mice in each treatment group and their corresponding controls were sacrificed, and the presence and motility of T. canis larvae in the brain were determined.With both therapeutical procedures the administration of albendazole reduced the number of larvae which reach the brain. However, for the same total dose, the administration of the drug every eight hours yielded results which were significantly superior to those produced by administering a single dose every 24 hours, reducing both the number of larvae in the brain and their motility.
PROX1 Utilizes Distinct Mechanisms to Induce Two Key Lymphatic Growth Factor Receptors:Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) and Fibroblast Growth Factor Receptor-3 (FGFR-3)

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The lymphatic vasculature is a network of unidirectional capillaries and ducts, which serve to return extracellular fluid and macromolecules to the systemic blood circulation. In addition, the lymphatic vessels have important roles in immune surveillance and fat absorption. Dysfunction of lymphatic vessels has profound physiological consequences. Insufficient lymph uptake results in lymphedema, a chronic disabling condition that currently has no cure. Lymphedemcanoccureither due to developmental defects (primary lymphedema) or due to injuries of existing lymphatic vessels (secondary lymphedema). The significance of lymphangiogenesis in tumour metastasis is demonstrated by the finding that increased lymphangiogenesis is associated with a higher rate of metastasis and poorer prognosis in cancer patients. Prox1, a homeoboxgene, regulates the development of the lymphatic vasculature by upregulating the expression of lymphatic endothelial markers and simultaneously repressing the expression of blood endothelial markers. To explore the mechanisms by which Prox1 establishes lymphatic cell fate, we compared Prox1 mediated activation oftwo key lymphatic cell surface receptors: theVascular Endothelial Growth Factor Receptor-3 (VEGFR-3) and theFibroblast Growth Factor Receptor-3 (FGFR-3) genes. Using a combination of luciferase gene reporter assays and immunoblotting, we compared the ability of different Prox1 constructs to activate either VEGFR-3 or FGFR-3 at both the mRNA and protein levels, respectively. Furthermore, we tested whether recombinant PROX1 protein was able to bind to the proximal promoter regions of VEGFR-3 and FGFR-3usingelectrophoretic mobility shift assays (EMSA). DNA binding deficient Prox1 versions did not activate the FGFR-3 promoter. In contrast, these versions of Prox1still efficiently activated transcription of the VEGFR-3 promoter. In agreement with our luciferase reporter gene assays, immunoblotting of HUVECs demonstrated that only infection with wt Prox1adenovirus increased expression of the FGFR-3 protein. Infection of HUVECs with adenoviral vectors encoding eitherwt Prox1orHDPD∆ Prox1was sufficient to induce a significant increase in VEGFR-3 protein levels. Surprisingly, our EMSA results with recombinant PROX1 demonstrated that PROX1 can bind to the promoter region of both VEGFR-3 and FGFR-3 genes via its DNA binding domain. We showed that PROX1 potentially binds to the promoter region of the VEGFR-3 gene via a consensus Prospero binding site (CGCCTCGGC). Our data demonstrates that, in endothelial cells, PROX1 utilizes distinct mechanisms to activate these two key endothelial growth factor receptors.
Pulmonary hypertension associated with busulfan

Field: Medicine (Health Sciences)

Busulfan is widely used to treat malignant diseases, particularly for therapeutic intensification prior to an autologous stem cell graft. Numerous side effects consecutive to busulfan are described, but few descriptions of pulmonary hypertension exist, while bronchiolitis obliterans remains a rare complication. We report the clinical observations of four patients from the French Pulmonary Hypertension Registry who experienced subacute pulmonary hypertension after receiving busulfan as preparation regimen before an autologous stem cell graft for malignancies (Hodgkin’s disease, Ewing’s sarcoma and primary large B cell lymphoma of the brain). Patients experienced severe pulmonary arterial hypertension 2 to 4.5 months after busulfan administration. Pulmonary hypertension improved after treatment with approved drugs for pulmonary arterial hypertension and/or corticosteroids. During the follow‐up period, two patients developed chronic respiratory insufficiency due to interstitial lung disease, leading to double lung transplantation. The pathological assessment of explanted lungs revealed interstitial lung fibrosis with advanced bronchiolar lesions and severe pulmonary vascular damage. Three of the four patients were still alive after 36 to 80 months and the fourth died unexpectedly and suddenly after 5 months. In conclusion, PAH is a rare but severe complication associated with busulfan chemotherapy in adults. Histological examinations provide evidence for diffuse pulmonary vascular damage combined with interstitial lung injury in most cases.
Clinical Implications of Chemokines in Acute and Chronic Hepatitis C Virus Infection

Field: Medicine (Health Sciences)

Hepatitis C virus (HCV), a non-cytopathic positive-stranded RNA virus, is one of the most common causes of chronic liver diseases such as chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Upon HCV infection, the majority of patients fail to clear the virus and progress to chronic hepatitis C. Chemokines are small chemotactic cytokines that direct the recruitment of immune cells and coordinate immune responses upon viral infection. Chemokine production during acute HCV infection contributes to the recruitment of immune cells with antiviral effector functions and subsequent viral clearance. In chronic HCV infection, however, continuous production of chemokines due to persistent viral replication might result in incessant recruitment of inflammatory cells to the liver, giving rise to persistence of chronic inflammation and liver injury. In this review, we will summarize the roles of chemokines in acute and chronic settings of HCV infection and the clinical relevance of chemokines in the treatment of hepatitis C.
The mechanism of iron uptake in Bacillus subtilis

Field: Immunology and Microbiology (Life Sciences)

A variety of phenolic compounds and hydroxamic acids reduced or prevented phenolic acid and coproporphyrin accumulation by iron-deficient cultures of Bacillus subtilis, but only if they were added to cultures with levels of iron which alone did not prevent accumulation. The compounds also increased iron uptake by iron-deficient cultures and norma) cultures. When radioactive catechol or 2,3-dihydroxybenzoic acid was used to increase iron uptake by iron-deficient cells, only very low levels of radioactivity remained associated with the cells. It is suggested that B. subtilis produces phenolic acids to solubilize iron; that other phenolic compounds or hydroxamic acids may substitute for the phenolic acids produced by B. subtilis; that the iron: phenolic acid complex does not enter the cell; and that the iron is removed from the complex at the cell surface and taken into the cell by an energy-dependent active transport system.
Misconception Analysis of Minimum Competency Assessment (AKM) Numeration of High School Students from Field Dependent Cognitive Style

Field: Psychology (Social Sciences)

The purpose of this study was to describe the extent of misunderstandings experienced by high school students while tackling Minimum Numerical Ability (AKM) questions modeled on the basis of domain-dependent cognitive styles. The number of students used as subjects in the study was her XI-IPS students in class three (3). The study was conducted at Tawangsari, Tulungagung District, Kedungwal, MA Darul Hikma, Tulungagung District, Jl KH Abu Mansur I. The study was conducted in even-numbered terms of the academic year 2021-2022. A targeted sampling method with the GEFT test (Group Embedded Figure Test) is used to determine research topics and classify students as having subject-dependent cognitive styles or not (subject-dependent). The results showed that students were categorized based on their AKM numbering test response results of low, medium, and high misconceptions. The number of questions is 3 questions. The first item is used to make sure that the indicator cannot repeat the concept. The second item is used to determine that the indicator fails to formulate the concept correctly in various mathematical representations. The index cannot determine the formula that answers the question. Indicators cannot apply formulas or algorithms to solve problems. The third item is used to see indicators of inability to use formulas or problem-solving algorithms. The results obtained show that subject-specific style students with low misunderstandings score higher from responses to AKM numbering questions than students with moderate and high misunderstandings.
ACUTE APPENDICEAL ABSCESS SIMULATING CECAL NEOPLASM

Field: Medicine (Health Sciences)

COEXISTENT cecal neoplasm with appendicular abscess is rather rare. In 1946 McLaughlin1in a review of the literature found only 11 such cases and added 1 of his own. In 1951 Hellsten and Ramström2of Sweden described four more cases. Thus we should be ever mindful of the fact that the differential diagnosis between an abscess in the right lower quadrant and cecal neoplasm should be made, if possible, in order to institute appropriate surgical therapy. In fact, the surgeon should be prepared to carry out ileocolic resection before laparotomy. In addition, when an appendiceal abscess is drained, one must be sure to reoperate at a later date in order to exclude any malignant growth.

REPORT OF A CASE

A 42-year-old man, a worker in a rubber factory, was admitted to the Somerville Hospital on Jan. 8, 1951, with a history of sudden constipation of two days' duration.
Introduction to the special issue: Challenges and practices to advance sustainable and inclusive practitioner research

Field: Arts and Humanities (Social Sciences)

This introduction to Language Teaching Research’s Special Issue “Challenges and Practices to Advance Sustainable and Inclusive Practitioner Research” introduces readers to central themes and issues surrounding inclusive and sustainable Practitioner Research (PR). Three traditions that foreground practitioners as active agents (Action Research, Exploratory Practice, Reflective Practice) are discussed, providing initial context. The article considers the value that teachers, learners, and teacher educators bring to research as practitioners with agency. Empowering practitioners in agenda-setting and supporting the practice and dissemination of practitioners researching their own classrooms and instructional environments, the authors argue, are vital for the fields of Applied Linguistics, English for Academic Purposes, and Language Education. The discussion highlights two central and intertwined tenets of PR work that feature in the articles of the special issue: inclusivity of students in the learning, teaching, and research processes, and sustainability fostered through supportive communities and the use of familiar pedagogic activities to sustain teachers’ investigative efforts. The four authors bring their unique perspectives as editors, authors, and practitioners to the discussions, providing an overview of the novel conceptual and empirical work undertaken in different parts of the world. We conclude that although inclusivity in PR may be hard to achieve, it is a goal worth striving for, with rich contributions for the field.
Age-Dependent Search Behavior in the Colorado Checkered Whiptail (Aspidoscelis neotesselatus)

Field: Agricultural and Biological Sciences (Life Sciences)

We compared movement and space use patterns of foraging adult and juvenile Colorado checkered whiptails (Aspidoscelis neotesselatus) in pinyon pine–juniper woodland. Through focal observations, we characterized (1) movement paths as a series of step lengths and turn angles at 30-s intervals, and (2) habitat use reflected by the proportion of time spent in different vegetation types and in the open. Adults and juveniles differed in both movement and habitat use. Adults spent more time in the open and in association with mountain mahogany (Cercocarpus montanus), while juveniles were more frequently found in association with dead wood, grass, and juniper (Juniperus monosperma). Adults also moved greater distances than juveniles and made use of larger areas. Movement patterns differed between age classes, with adults having longer step lengths. Adults and juveniles also engaged in different step length–turn angle sequences. For both classes, movement characteristics differed with habitat type.
Bias-Corrected and Variance-Corrected MLE for the New Median Based Unit Weibull Distribution (MBUW)

Field: Mathematics (Physical Sciences)

Abstract

As the maximum likelihood method is the most commonly used method for parameter estimation being unbiased, consistent, efficient, and asymptotically normal, MLE is used to fit the new distribution (MBUW). But in small to moderate sample sizes, this MLE estimator is biased unlike the MLE estimators obtained from large sample sizes. In this paper, the Bias-corrected approach for this distribution is discussed and applied to real data analysis. The MLE estimators of MBUW obtained from some optimization techniques like the derivative free Nelder Mead algorithm suffer from a significant high correlation reflected in high covariance between the parameters. Also, this association between the parameters affects the variances which may be inflated enough to approach infinity hampering the construction of confidence intervals for each parameter. This problem may arise with any optimization technique which necessitates remedies trying to fix it. The author also elaborates a variance correction approach heavily relying on re-parameterizing the negative log-likelihood.
Antibiotic Use After Removal of Penicillin Allergy Label

Field: Medicine (Health Sciences)

D Vyles, A Chiu, J Routes. Pediatrics. 2018;141(5):e20173466

To evaluate the clinical and economic impact of negative penicillin testing results for children with a previous penicillin allergy label.

This study included caregivers and primary care providers (PCPs) of 100 children between the ages of 4 and 18 years with negative test results for penicillin allergy after percutaneous, intracutaneous testing and an oral challenge.

A follow-up case series investigation was performed on 100 children with “low-risk” allergy symptoms who had a negative penicillin allergy evaluation result. Low-risk symptoms included a nonurticarial rash, itching, diarrhea, and vomiting. The study authors hypothesized that no serious allergic reactions would occur with reexposure and that prescribing practices would change as a result of testing. A brief telephone survey was administered to parents and PCPs. Parents were questioned regarding antibiotic use since penicillin testing, any recent allergic reactions, parental comfort level with future penicillin use, …
Evaluation of the effectiveness of the use of humic biofertilizer in the cultivation of soybeans in conditions of unstable moisture

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract The results of field studies to assess the effectiveness of the use of humic biofertilizer “AgroVerm” in the technology of cultivation of soybeans of the zoned variety “Vilana” in the treatment of seeds and crops in the zone of unstable moisture are presented. It has been established that, on average, over the years of research (2017-2020), the use of biofertilizer in various variations of its application increases the stress resistance of soybean plants to adverse climatic factors, promotes the intensive formation of nodules on the roots of plants (on average, by 8 more options). an increase in the number of beans per plant (from 1 to 3 pcs.) and the weight of 1000 seeds (from 4.5 to 7.8 g), and also increases the yield of soybean seeds from 2.0 to 2.3 q/ha.