jimnoneill/paper-to-field-training huggingface dataset:
Galectin-12 in Cellular Differentiation, Apoptosis and Polarization

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains joined by a linker region. Galectin-12 is predominantly expressed in adipose tissue, but is also detected in macrophages and other leukocytes. Downregulation of galectin-12 in mouse 3T3-L1 cells impairs their differentiation into adipocytes. Conversely, overexpression of galectin-12 in vitro induces cell cycle arrest in G1 and apoptosis. Upregulation of galectin-12 and initiation of G1 cell cycle arrest are associated with driving pre-adipocytes toward terminal differentiation. Galectin-12 deficiency increases insulin sensitivity and glucose tolerance in obese animals. Galectin-12 inhibits macrophage polarization to the M2 population, enhancing inflammation and decreasing insulin sensitivity in adipocytes. Galectin-12 also affects myeloid differentiation, which is associated with chemotherapy resistance. In addition to highlighting the above-mentioned aspects, this review also discusses the potential clinical applications of modulating the function of galectin-12.
Chemistry under light-matter strong coupling

Field: Chemistry (Physical Sciences)

Cette thèse s’inscrit dans le cadre de la chimie polaritonique et explore les effets du couplage fort lumière-matière sur les propriétés moléculaires. Dans ce contexte, deux aspects principaux sont discutés – le rôle joué par la symétrie moléculaire dans le couplage fort vibrationnel et le changement de polarité du solvant induit lorsque les modes de vibration moléculaires sont couplés au champ résonant d’une cavité optique de Fabry-Perot. De plus, cette thèse a permis, grâce au développement de nouveaux dispositifs microfluidiques de type Fabry-Perot, d’étudier pour la première fois des systèmes sous couplage fort vibrationnel par spectroscopie RMN, ouvrant ainsi de nouvelles perspectives pour étudier l’influence du couplage fort sur les propriétés moléculaires et plus particulièrement sur la réactivité chimique.
Harvester Ants (Hymenoptera: Formicidae) Discriminate Among Artificial Seeds with Different Protein Contents

Field: Agricultural and Biological Sciences (Life Sciences)

Workers of colonies of the western harvester ant, Pogonomyrmex occidentalis, were recruited to patches of artificial seed of the same caloric value but different protein content. Rates of forager returns with artificial seeds containing five percent protein were nearly twice those of zero percent protein. Differences in foraging rates on artificial seeds often and twenty percent protein compared to foraging rates on zero percent protein seeds were not different from the comparison of foraging rates on five percent and zero percent protein seeds. There were no differences in foraging rates on zero percent protein seeds, 0.5 percent and one percent protein seeds. P. occidentalis presented with patches containing equal amounts of zero, five, ten, and twenty percent protein seeds returned equal amounts of each protein content seed type to the colonies. When presented with high quality seed patches in the same location for four successive days, the rates of forager returns increased over time. When seed patch locations were switched, P. occidentalis' rate of return of zero protein content seeds was the same as for the five percent protein seeds at that location the previous day. Seeds with protein content between one and two percent represent a threshold for seed quality that affects the foraging rate of P. occidentalis workers.
Transforming the Orthodox landscape of Ottoman Istanbul during the early modern period

Field: Arts and Humanities (Social Sciences)

The Ottoman conquest of Constantinople in 1453 permanently altered the sacred landscape of this important Greek Orthodox city. The gradual transformation of the Orthodox landscape in Ottoman Istanbul provides an interesting example of a landscape in transition. This chapter focuses on the formation of Greek Orthodox neighbourhoods after the Ottoman conquest in order to explore the reciprocal relationship between the location of religious buildings – especially the Patriarchate, the chief church of the Greek Orthodox patriarch – and surrounding Orthodox communities. It pays particular attention to the previously neglected social features of the developments. The chapter examines the relationship between the evolution of the sacred Orthodox landscape of Ottoman Istanbul and wider shifts in the city's population. It analyses the immediate consequences of the Ottomans' arrival in the city. The presence of royal members of the semi-autonomous principalities of Moldavia and Wallachia added a special character to the Orthodox landscape of Fener.
Analysis of switch-level faults by symbolic simulation

Field: Computer Science (Physical Sciences)

Article Free Access Share on Analysis of switch-level faults by symbolic simulation Authors: Lluís Ribas-Xirgo Centre Nacional de Microelectrònica, CNM (CSIC), Universitat Autònoma de Barcelona, UAB, Campus UAB, 08193 Bellaterra, Barcelona, Spain Centre Nacional de Microelectrònica, CNM (CSIC), Universitat Autònoma de Barcelona, UAB, Campus UAB, 08193 Bellaterra, Barcelona, SpainView Profile , Jordi Carrabina-Bordoll Centre Nacional de Microelectrònica, CNM (CSIC), Universitat Autònoma de Barcelona, UAB, Campus UAB, 08193 Bellaterra, Barcelona, Spain Centre Nacional de Microelectrònica, CNM (CSIC), Universitat Autònoma de Barcelona, UAB, Campus UAB, 08193 Bellaterra, Barcelona, SpainView Profile Authors Info & Claims DAC '95: Proceedings of the 32nd annual ACM/IEEE Design Automation ConferenceJanuary 1995Pages 352–357https://doi.org/10.1145/217474.217554Published:01 January 1995Publication History 5citation181DownloadsMetricsTotal Citations5Total Downloads181Last 12 Months4Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Supplementary Material for: Laparoscopic versus open approach for Siewert-type II/III adenocarcinoma of the esophagogastric junction: A systematic review and meta-analysis

Field: Medicine (Health Sciences)

Introduction Due to the specific location, the potential advantages of laparoscopic gastrectomy (LG) compared with open gastrectomy (OG) for Siewert II/III adenocarcinoma of the esophagogastric junction (AEG) remain uncertain. The current study aimed to compare the short- and long-term outcomes of LG versus OG in treating Siewert type II/III adenocarcinoma. Methods We searched PubMed, Embase, Web of Science, Medline (hosted by Ovid), and the Cochrane Library for publications, till July 2022 and then used the Revman5.3 software for statistical analysis. Results Ten publications from 10 medical centres were included, with 1516 cases from the LG group and 1219 from the OG group. Meta-analysis results showed that the LG group was superior to the OG group in intraoperative blood loss, hospital stay, lymph nodes retrieved, time to ambulation, time to first flatus, time to diet, 5-year overall survival, and 5-year disease-free survival. There was no significant difference between the two groups in operative time, overall complications, proximal margin, distal margin, pulmonary infection, anastomotic leakage, mortality, ileus, or absolute infection. Conclusions Compared with OG, LG is associated with better surgical and long-term outcomes in Siewert type II/III AEG. LG is a safe and feasible option for treating Siewert type II/III AEG. However, studies with large sample sizes, long follow-up periods, and rigorous designs are needed for verification.
The nuclear factor SPOC1 enhances HIV-1 integration but suppresses viral gene expression

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

In this study, the role of the nuclear protein SPOC1 for HIV-1 replication was investigated. SPOC1 was shown to increase proviral integration and hence the total number of infected cells. Nonetheless, SPOC1 was degraded by the viral accessory protein Vpr post integration. This degradation evolved most likely due to repressive effects of SPOC1 on viral gene expression. Hence, SPOC1 is not a bona-fide antiviral restriction factor but is important for efficient HIV-1 integration. At later steps, Vpr degrades SPOC1 to counteract its antiviral functions.
Predictors of Gambling-Related Problems in Adult Internet Gamblers

Field: Psychology (Social Sciences)

The use of the Internet to gamble has become increasingly prevalent in recent years.\nAlthough researchers have suggested that adult Internet gamblers are at high risk for\ndeveloping a gambling disorder, few studies, overall, have been conducted on the effects\nof Internet gambling. Furthermore, conflicting research exists regarding what moderates\ngambling-related problems. The purpose of this quantitative study was to determine if\nage, gender, and emotions prior to the gambling experience are related predictors of\nInternet problem gambling severity. A retrospective design was used. The pathways\nmodel was used to support the belief that emotions felt before an Internet gambling\nsession are associated with the severity of the gambling problem. Data were obtained\nfrom adult Internet gamblers who had Internet gambled in the preceding week. One\nhundred and fifty participants completed an online survey about the emotions they felt\nbefore an Internet-gambling session and self-reported the negative consequences of their\ngambling. The survey contained demographic questions, questions from the Positive and\nNegative Affect Schedule (to assess emotions felt before participants' last Internet\ngambling session), and questions from the Problem Gambling Severity Index. The results\nof the multiple linear regression analysis were significant, indicating that, as a group,\nparticipants' age, gender, and emotions felt prior to the gambling experience predicted\ntheir problem gambling severity. This study can assist with prevention, early intervention,\nand treatment of adult Internet gamblers.
Entropy and Heat Capacity of the transverse momentum distribution for pp collisions at RHIC and LHC energies

Field: Physics and Astronomy (Physical Sciences)

We investigate the transverse momentum distribution (TMD) statistics from three different theoretical approaches. In particular, we explore the framework used for string models, wherein the particle production is given by the Schwinger mechanism. The thermal distribution arises from the Gaussian fluctuations of the string tension. The hard part of the TMD can be reproduced by considering heavy tailed string tension fluctuations, for instance, the Tsallis $q$-Gaussian function, giving rise to a confluent hypergeometric function that fits the entire experimental TMD data. We also discuss the QCD-based Hagerdon function, another family of fitting functions frequently used to describe the spectrum. We analyze the experimental data of minimum bias pp collisions reported by the BNL Relativistic Heavy Ion Collider (RHIC) and the CERN Large Hadron Collider (LHC) experiments (from $\sqrt{s}=0.2$ TeV to $\sqrt{s}=13$ TeV). We extracted the corresponding temperature by studying the behavior of the spectra at low transverse momentum values. For the three approaches, we compute all moments, highlighting the average, variance, and kurtosis. Finally, we compute the Shannon entropy and the heat capacity through the entropy derivative with respect to the temperature. We found that the $q$-Gaussian string tension fluctuations lead to a monotonically increasing heat capacity as a function of the center of mass energy, which is also observed for the Hagedorn fitting function. This behavior is consistent with the experimental observation that the temperature slowly rises with increments of the collision energy.
An expanded phase I/II trial of cyclophosphamide, etoposide, and carboplatin plus total body irradiation with autologous marrow or stem cell support for patients with hematologic malignancies

Field: Medicine (Health Sciences)

AbstractThe major cause for failure of autologous stem cell transplantation for hematologic malignancies is the risk of recurrent disease. As a result, new treatment regimens that include novel agents or combinations of agents and approaches are needed. The current report describes a large Phase I/II, single-center trial that includes 60 patients with a variety of hematologic malignancies. These patients received a fixed dose of carboplatin (1 g/m2/d × 72 hours by CI) etoposide (600 mg/m2/d × 3 days) and cyclophosphamide (2 g/m2/d × 3 days), plus escalating doses of total body irradiation (TBI) (at 1000, 1200, and 1295 cGy) over 3 days. Eleven patients received infusion of autologous marrow, 32 received peripheral blood stem cells, and 17 patients received both. The maximum tolerated dose of this regimen was a radiation dose of 1200 cGy given in 200-cGy fractions BID × 3 days. The dose-limiting toxicity was mucositis, with 97% of patients requiring narcotic analgesia for mouth pain. Overall treatment-related mortality was 6.7%, with 2 of the 4 deaths occurring in a group of 9 patients aged 60 and older. Responses were seen in all patient groups, but the most encouraging outcomes were seen in 12 patients with high-risk or advanced acute myelocytic lymphoma (AML), 7 of whom remain alive and free of disease beyond 5 years. This regimen is intensive and causes considerable mucositis but is otherwise well tolerated and has demonstrated activity in a number of hematologic malignancies, especially AML.
Surgery during holiday periods and prognosis in oesophageal cancer: a population-based nationwide Swedish cohort study

Field: Medicine (Health Sciences)

Objective Previous studies indicate an increased short-term and long-term mortality from major cancer surgery performed towards the end of the working week or during the weekend. We hypothesised that the prognosis after major cancer surgery is also negatively influenced by surgery conducted during holiday periods. Setting Population-based nationwide Swedish cohort study. Participants Patients undergoing oesophagectomy for oesophageal cancer between 1987 and 2010. Among 1820 included patients, 206 (11.3%) and 373 (20.5%) patients were operated on during narrow and wide holiday periods, respectively. Interventions Narrow (7 weeks) and wide (14 weeks) Swedish holiday periods. Primary and secondary outcome measures 90-day all-cause, 5-year all-cause and 5-year disease-specific mortality. Results Narrow holiday period did not increase all-cause 90-day (HR=0.84, 95% CI 0.53 to 1.33), all-cause 5-year (HR=1.01, 95% CI 0.85 to 1.21) or disease-specific 5-year mortality (HR=1.04, 95% CI 0.87 to 1.26). Similarly, wide holiday period did not increase the risk of 90-day (HR=0.79, 95% CI 0.55 to 1.13), all-cause 5-year (HR=0.96, 95% CI 0.84 to 1.1) or disease-specific 5-year mortality (HR=1.03, 95% CI 0.89 to 1.19). Conclusions No measurable effects of holiday periods on short-term or longer term mortality following surgery for oesophageal cancer were observed in this population-based study, indicating that an adequate surgical experience was maintained during holiday periods.
Paediatric supraventricular tachycardia patients potentially more at risk of developing psychological difficulties compared to healthy peers

Field: Medicine (Health Sciences)

Abstract Aim Assess executive and socio‐emotional/behavioural functioning in paediatric supraventricular tachycardia (SVT) patients. Methods SVT patients aged 7‐17 who had not undergone catheter ablation were included. Parents completed the Child Behaviour Checklist (CBCL/6‐18) and the Behavior Rating Inventory of Executive Functioning (BRIEF). Participants age 11‐17 years completed the Youth Self‐Report (YSR/11‐18) and the BRIEF Self‐Report (BRIEF‐SR). One‐sample z test was used to compare questionnaire results to the average t‐score range (M = 50, SD = 10). Results Thirty (18 female) children/adolescents participated (M = 12.6 years old, SD = 3.2 years) with a mean SVT onset age of 7 years (SD = 4.3 years). BRIEF and BRIEF‐SR results suggested no difference in executive functioning from average. Mean t‐scores of CBCL/6‐18 and YSR/11‐18 subscales Anxious/Depressed, Withdrawn/Depressed, Somatic Complaints, Thought Problems, Diagnostic and Statistical Manual of Mental Disorders (DSM) Affective Problems, DSM Anxiety Problems and DSM Somatic Problems were significantly elevated compared to average. YSR/11‐18 subscales Social Problems, Attention Problems, Internalizing Problems, DSM ADHD Problems and DSM Oppositional Defiant Problems had elevated mean t‐scores compared to average. Effect sizes were small to medium (0.2 ≤ d ≤ 0.8). Conclusion Paediatric patients with SVT potentially have a greater risk of developing behaviour, especially internalizing, problems compared to similarly aged children/adolescents without SVT.
Hemorrhagic stroke following scorpion sting. A case report

Field: Medicine (Health Sciences)

Scorpions inhabit many countries mainly undeveloped countries but it's present in developed nations where the weather is hot and wet. There are few cases describe in literature that refer to scorpion sting and stroke which the most common event is the ischemic stroke. In this, it's case related a hemorrhagic stroke after scorpion sting occurred in Sertaozinho, Brazil and a brief literature review.
Perceived Experience, Perceived Value and Customer Satisfaction as Antecedents to Loyalty among Hotel Guests

Field: Business, Management and Accounting (Social Sciences)

Despite the hospitality industry reeling under the impact of COVID-19, few studies provide practitioner-oriented perspectives capturing dimensions of guest loyalty within emerging markets. The researchers examine the influence of perception of value and experience on guest loyalty within the context of the Indian hotel industry. A random questionnaire survey of 170 occupants across three renowned hotels during the first week of COVID-19 induced lockdown in India and subsequent analysis using structural equation modeling conﬁrm that both guest loyalty and satisfaction continue to be positively inﬂuenced by perception of value and the service experience. Both guest satisfaction and loyalty are strongest among guests who perceive high service value. Guest loyalty is also indirectly influenced by value perception and service experience through the mediation of customer satisfaction. The relationship between perceived experience and guest satisfaction is found to be stronger when perceived service value is higher. The hospitality industry, a vector of pandemic occurrence, can use this opportunity to reset business models. While micro-segmentation is called for in positioning offerings to target groups, efforts to reduce customer sacrifice by simplification of pricing and transaction procedures should be implemented across the spectrum in adjusting to the new normal.
Developmental anatomy of Coprinus

Field: Agricultural and Biological Sciences (Life Sciences)

The aim of this study has been to compare the ontogenetic structures of as many species of Coprinus as possible in order to obtain a better insight into their mutual relationships. The sequence of development of the parts in the first phases of primordium development has been traced with greater precision here; several degrees of rupthymenial hymenophore development have been distinguished; the veil and pileipellis structures and the corresponding terminology have been critically discussed. Finally, an attempt has been made to establish phylogenetic relationships between about 27 species, but to acheive a higher degree of accuracy in this field, ontogenetic information concerning still more species is required.
Not only encoding and retrieval: The enactment effect as a function of task preparation

Field: Psychology (Social Sciences)

Three experiments examined the implications of adding a fourth preparation stage to the encoding‐retention‐retrieval stage analysis of memory. Action memory was selected as the research domain. The results demonstrated that systematic variation of the preparation stage yields new insights about enactment effects in memory. Together with effects of enactment in the preparatory stage, enactment was also shown to give differential effects in encoding and retrieval, with interactions between these three factors. The experimental results were discussed in relation to a strategy processing interpretation of action memory.
Establishment of an International Registry of Patients with Inherited FXIII Deficiency.

Field: Medicine (Health Sciences)

Abstract Inherited factor XIII (FXIII) deficiency is a rare autosomal recessive disorder affecting approximately one out of one to three million people. FXIII deficiency is characterized by a lifelong bleeding tendency, impaired wound healing and spontaneous abortions in females. In 1993, the European Thrombosis Research Organization (ETRO) Working Party on FXIII initiated a Europe-wide questionnaire on inherited FXIII deficiency. Since 2005, the registry has been endorsed by the Factor XIII Subcommittee of the Scientific and Standardization committee (SSC) of the ISTH. The analysis of 104 European patients demonstrated that the most common bleeding symptoms were subcutaneous bleeding (57%) followed by delayed umbilical cord bleeding (56%), muscle hematoma (49%), hemorrhage after surgery (40%), hemarthrosis (36%), and intracerebral bleeding (34%). Prophylactic treatment was initiated in about 70% of all patients. FXIII-B subunit-deficient patients had a milder phenotype than patients with FXIII-A subunit deficiency.The most frequent mutation affecting the F13A gene was a splice site mutation in intron 5 (IVS5-1G&gt;A).This mutation was found in eight (17%) of 46 analyzed families.The haplotype analysis of patients carrying the IVS5-1A allele was consistent with a founder effect. Recently, we created a new FXIII database website (http://www.f13-database.de) with information about FXIII proteins, genes, mutations and polymorphisms. This website also includes a new questionnaire. Information provided by this questionnaire will allow better understanding of the differences of diagnostic and treatment possibilities in various parts of the world, and it will help to understand the impact of reduced FXIII activity in heterozygous relatives and finally, it will generally increase our knowledge on this rare disease. We hope that our initiative to establish a new international FXIII registry will be actively supported by the community involved in caring for FXIII deficient patients.