jimnoneill/paper-to-field-training huggingface dataset:
Efficiency and safety of thread implantology in the long term: data from a pathomorphological study

Field: Dentistry (Health Sciences)

The evolution of methods used in aesthetic medicine includes a transition to less invasive procedures with high safety and minimal recovery time. That is why numerous non-invasive methods for correcting involutive changes in facial skin (thread lifting, hardware techniques) have been studied for effectiveness and safety over the past decades. Such techniques can improve treatment results and avoid or delay surgical intervention. Material and methods . The work involved a pathomorphological study of material taken by biopsy at the sites of thread implantation and surrounding tissues (1 cm indentation) (Nano spring, Excellence Visage, Excellence Visage HA) within 12 months after thread lifting. Paraffin sections with a thickness of 5–7 microns were made from ready-made paraffin blocks and stained with: hematoxylin – eosin; according to the Weigert-Van Gieson method; Sirius Red paint. Using a microscope with a Sony digital photo attachment with a resolution of 12 megapixels, five photographs were taken from each histological specimen. Research results . As a result of a pathomorphological study of a flap of skin and subcutaneous fat with a synthetic thread in the adipose tissue, it was revealed that along the periphery of the studied material there was moderate chronic inflammation (giant cells of the type of foreign body cells, lymphocytes, fibroblasts) and weak fibrosis, as well as a predominance type I collagen in the skin, and type III collagen predominated in subcutaneous fat tissue.
Multi-omics reveals principles of gene regulation and pervasive non-productive transcription in the human cytomegalovirus genome

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

This upload contains the scripts as well as the source code of the programs written throughout the study, as well as the mapped reads-data to fully generate all the figures and tables for the accompanying publication. The bash-script titled 1_start.bash starts the whole analysis pipeline. However, each line is commented and could therefore be copy and pasted into the command line to execute just single steps of the pipeline. System requirements: Java 1.8, R
The Experiences and Perceptions of First Contact Practitioners in Primary Care—A Qualitative Systematic Review

Field: Health Professions (Health Sciences)

ABSTRACT Background First Contact Practitioners (FCP) have developed as a more advanced physiotherapy clinical role delivering specialist MSK services in GP practice settings. They aim to support GPs in effectively managing increasing patient workloads. As FCPs are now a more established NHS role, it is important to understand how these clinicians perceive their roles to guide and support future service development. Aims To review the current evidence regarding the experience of FCPs in the UK. To understand how FCPs perceive their role. To gain an insight into FCP practice which can inform future primary research studies. Method A systematic review of FCP primary qualitative research studies. Multiple database and grey literature search with screening following PRISMA guidelines. Qualitative critical appraisal and analysis used tools and frameworks from the Joanna Briggs Institute. Results The review reports on 11 included studies which informed the creation of six key concepts impacting upon FCP role experience and perceptions. These were complexity, competency and role development, role understanding, job satisfaction, wellbeing and burnout and service delivery. Conclusion FCP clinicians feel broadly positive about their roles, although they report a clear risk of burnout and associated negative impact on their wellbeing. Job satisfaction is linked to adequate training and developing the competencies required to manage patients in an environment of clinical uncertainty. Having access to regular clinical mentorship is a key requirement and FCPs must adapt to the specific demands of work in a GP practice environment.
Volume Dynamics and Multimarket Trading

Field: Economics, Econometrics and Finance (Social Sciences)

Abstract The trading of shares of the same firm in multiple markets has become common over the last 30 years, but there is little empirical evidence on the extent to which investors actively exploit multimarket environments. We introduce a volume-based measure of multimarket trading to address this question. Analyzing a large set of cross-listed firms, we find higher multimarket trading among markets with similar designs and strong enforcement of insider trading laws and for firms with higher institutional ownership. These findings are important for firms evaluating the benefits of cross listing and for markets competing for order flow.
Phosphorylated troglitazone activates PPAR and inhibits vascular smooth muscle cell proliferation and proteoglycan synthesis

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Phosphorylation of a-tocopherol produces an entity with enhanced antiatherogenic properties. Troglitazone, an a-tocopherol derivative of a 2,4-thiazolidinedione nucleus, is an antidiabetic agent that shows fatal idiosyncratic hepatotoxicity, a property not shared by later agents. We investigated the effects of phosphorylation of troglitazone (to yield &quot;phosphoglitazone&quot;) on the biochemical pharmacologic properties of troglitazone. We investigated its ability to act as a PPARy agonist and to inhibit 2 atherogenic properties of vascular smooth muscle cells (vSMC)-proliferation and proteoglycan synthesis. PPARy activity was assessed in a transfection assay. Proliferation was assessed by [H]-thymidine incorporation and cell counting and proteoglycan synthesis by [S]-sulfate incorporation using human vSMCs stimulated with platelet-derived growth factor (PDGF; 50 ng/mL) and transforming growth factor (TGF)-b (2 ng/mL). Phosphoglitazone was a full agonist for PPARy with a potency and efficacy similar to troglitazone. Phosphoglitazone also inhibited cell proliferation and proteoglycan synthesis with potency similar to troglitazone. We conclude that phosphorylation retains the pharmacologic activity of troglitazone while decreasing its lipophilicity and therefore potentially its toxicity. A phosphorylated derivative of a 2,4-thiazolidinedione warrants further investigation as a potential new therapeutic agent for the treatment of insulin resistance and Type 2 diabetes.
Occurrence of gastric ulcer after Nissen fundoplication.

Field: Medicine (Health Sciences)

Of 160 patients who underwent Nissen fundoplication for treatment of symptomatic peptic reflux esophagitis, five patients (3.1%) developed gastric ulcers. Four of these five patients experienced the "gas-bloat" syndrome. All ulcers were located on the lesser curvature of the stomach. Analyses of our experience with use of various types of hiatal hernia repair suggests that creation of the valvuloplastic mechanism unique to the Nissen procedure may be of etiologic significance in the development of gastric ulcers following this procedure.
MH UNet: A Multi-Scale Hierarchical Based Architecture for Medical Image Segmentation

Field: Computer Science (Physical Sciences)

UNet and its variations achieve state-of-the-art performances in medical image segmentation. In end-to-end learning, the training with high-resolution medical images achieves higher accuracy for medical image segmentation. However, the network depth, a massive number of parameters, and low receptive fields are issues in developing deep architecture. Moreover, the lack of multi-scale contextual information degrades the segmentation performance due to the different sizes and shapes of regions of interest. The extraction and aggregation of multi-scale features play an important role in improving medical image segmentation performance. This paper introduces the MH UNet, a multi-scale hierarchical-based architecture for medical image segmentation that addresses the challenges of heterogeneous organ segmentation. To reduce the training parameters and increase efficient gradient flow, we implement densely connected blocks. Residual-Inception blocks are used to obtain full contextual information. A hierarchical block is introduced between the encoder-decoder for acquiring and merging features to extract multi-scale information in the proposed architecture. We implement and validate our proposed architecture on four challenging MICCAI datasets. Our proposed approach achieves state-of-the-art performance on the BraTS 2018, 2019, and 2020 Magnetic Resonance Imaging (MRI) validation datasets. Our approach is 14.05 times lighter than the best method of BraTS 2018. In the meantime, our proposed approach has 2.2 times fewer training parameters than the top 3D approach on the ISLES 2018 Computed Tomographic Perfusion (CTP) testing dataset. MH UNet is available at https://github.com/parvezamu/MHUnet.
The Phase Change Heat of Water in the Pore Space of Rocks Based on DSC Studies

Field: Earth and Planetary Sciences (Physical Sciences)

This research investigates the phase change behavior of water within the pore space of Devonian carbonate rock samples using Differential Scanning Calorimetry (DSC) across a temperature range of −80 to 0 °C. This study focuses on dolomite and limestone samples, all with porosities below 3%, an area not extensively covered in previous literature. Significant endothermic effects were observed at temperatures below −2 °C, challenging conventional understanding. The study reveals that the latent heat of phase change in these systems can exceed 334.2 J/g, the known value for bulk water, indicating unique thermodynamic properties of water in confined spaces. For the dolomite rock sample, observed endothermic heat effects below −2 °C were 23.5% and 26.7% of total phase change energy. The cumulative pore volume calculated using the thermoporometry method was found to be higher than expected from water occupancy alone, independent of assumptions about the thickness of the adsorbed unfreezable water layer or pore shape (spherical or cylindrical). This research provides novel insights into unfrozen water content calculations, significantly enhancing frost durability assessments and the geoengineering industry.
Assessing and Mapping the Environmental Impacts of Best Management Practices in Nitrate-Vulnerable Areas

Field: Environmental Science (Physical Sciences)

This investigation explores the impact of various management practices on nitrate leaching and crop yield in two specific areas in Slovenia. The issue of nitrate leaching from agricultural land is a worldwide threat to drinking water, and despite years of research efforts, universal solutions are still unknown. The two chosen study sites are significant because of their importance for agricultural production and because groundwater aquifers beneath are main sources of drinking water, which makes imposing mitigation measures challenging. One of the areas was reported to be of “bad” status according to the Water Framework Directive criteria, while the other is at risk of reaching this status if nitrate concentrations in groundwater continue to rise. This research used the SWAT model to simulate nitrate leaching and crop yield changes under different agricultural scenarios on different soil types. It aimed to accomplish two objectives: first, to identify parts of the case study areas where the existing combination of soil conditions and agricultural practices enables a high potential for nitrate leaching; second, to identify agricultural practices that decrease nitrate leaching from various soil types while maintaining crop yields in each area. By identifying the most vulnerable locations and the most promising practices, we generated a chart of best management practices for specific soil types as a guide that extension services can use to advise farmers on potential management improvements. The main findings demonstrate that reducing fertilizer application, both organic and inorganic, in areas where the rates exceed crop requirements may not have a significant impact on crop production. However, these reductions often resulted in a noticeable decrease in nitrate exports. The results also showed that soil type is crucially important and should always be considered when evaluating the effects of agricultural management on crop yields and nitrate leaching.
Andrew Curran, Diderot and the art of thinking freely

Field: Arts and Humanities (Social Sciences)

Ce livre se situe dans la grande tradition des biographies intellectuelles et mêle avec bonheur des récits de vie et des analyses textuelles. Profitant des travaux antérieurs tout en proposant des perspectives ou des accents originaux, A. Curran propose un texte vivant et riche, digne de son objet ! Comme l’indique le titre, A. Curran a fait le choix de mettre en avant un enjeu transversal : l’art de penser librement. Dès le prologue, qui commence par la scène étonnante qui vit un groupe de v...
Leukogram patterns significance and prevalence for an accurate diagnosis in dogs

Field: Veterinary (Health Sciences)

Interpretation of changes in WBC (White Blood Cell) provides valuable information for guiding the veterinarian to establish the diagnosis for a wide range of diseases. Leukocyte changes, both quantitative and qualitative, are always secondary, so the control and therapeutic success is dependent on the identification of the primary condition. The purpose of this study was the association between the magnitude of quantitative changes in leukocytes and the primary conditions in which they occurred, to facilitate a faster orientation of the diagnosis. From dogs with internal affections and based on inclusion and exclusion criteria, the survey evaluated 447 complete blood counts (CBC). In 272 of CBC analyzed, the number of leukocytes was in the physiological range (i.e. 6,000-17,000 cells × µL-1 blood), but in 131 cases, the leukocytes exceeded the upper limit, and in 44 cases, leukocytes were below the lower limit. In terms of leukocytosis, affections of the digestive system had the highest prevalence, while leucopenia, was more present in the circulatory system pathologies. The cases of leukocytosis depending on the severity were: mild (73 cases), moderate (41), and severe leukocytosis (15) and respectively, two extreme leukocytosis cases, statistically emerging: p <0.01 for IBD (inflammatory bowel disease), acute pancreatitis, ehrlichiosis, chronic babesiosis and respectively p <0.001 for acute lymphoblastic leukemia. Results revealed that infections source (devoid of parvovirosis), inflammation of the digestive tract was frequently accompanied by moderate leukocytosis, while the parvoviral caused enteritis conducted, in the early stages, to leukopenia. In bronchopneumonia, the leukocytosis was moderate, while inflammation of the anterior airways caused mild leukocytosis. Moderate leukocytosis was found also in the splenic, hepatic, and pulmonary neoplasm, and the acute lymphoblastic leukemia developed with severe leukocytosis and chronic leukemia with extreme leukocytosis.
Inter-agency team, final report, 1992

Field: Social Sciences (Social Sciences)

Inter-Agency Team Final Report, Appendix: Local police departments, materials collected by the Inter-Agency Team regarding the policies, procedures, and operations of several local police departments aside from the Los Angeles Police Department, 1992. PART OF SERIES: In addition to analyzing the 1992 riots as a whole, the Webster Commission also divided into several smaller task forces and study groups, each of which addressed one specific aspect of the civil disturbance. The series consists of reports and appendices produced by five of these groups: the Chronology Team, the Public Officials and Community Team, the LAPD Team, the Comparisons Study Group, and the Inter-Agency Team. Also included are two copies of Webster Scope, a report that interprets the riots and their cumulative effects primarily through graphs, charts, statistics, and figures, and several research memoranda that discuss the legality of several riot-response tactics. PART OF SUBSERIES: Materials related to a final report issued by the Webster Commission's Inter-Agency Team. which evaluated the collaboration between the LAPD and other law enforcement agencies in the advent of the 1992 riots. Included is a copy of the final report and the report's appendices, which are comprised of interviews, memoranda, statistical analyses, handbooks, and other miscellaneous documents.
Multidimensional Perspective to Data Preprocessing for Model Cognition Verity

Field: Computer Science (Physical Sciences)

Reliable data analysis depends on effective data preparation, especially since AI-driven business intelligence depends on unbiased and error-free data for decision-making. However, developing a reliable dataset is a difficult task that requires expertise. Due to the costly damage a negligible error in data can cause to a system, a good understanding of the processes of quality data transformation is necessary. Data varies in properties, which determines how it is generated, the errors in it, and the transformations it needs to undergo before it is fed into a model. Also, most data used for analytics is sourced from public stores without means to verify its quality or what further steps need to be taken in preprocessing it for optimal performance. This chapter provides a detailed description of practical and scientific procedures to generate and develop quality data for different models and scenarios. Also, it highlights the tools and techniques to clean and prepare data for optimal performance and prevent unreliable data analytics outcomes.
The cross-management of events

Field: Business, Management and Accounting (Social Sciences)

A morphosynthetic rethink of events stresses their interstitial nature and thereby leads to a holistic inter-industry outlook that I label cross-management. This represents a broader paradigm enabling the intersectorality of event practices via the management of overlapping systems in which events are embedded. It takes us to a cross-cutting path looking for synergies among different events, and between events and other entities. Accordingly, I delineate in this chapter the presuppositions of cross-management along with its portfolio, ontological eventscape, polythematic, and heritage exigencies. Then, I introduce a framework for cross-management offering the most comprehensive analytic lens and operational practice due to its multidimensional, interrelational, and transdisciplinary premises. The framework seeks to foster the interconnectedness of event and non-event elements (community assets), and particularly their reciprocal integration orchestrating the core product and supplementary services. Research implications are drawn for cultivating synergies and enhancing relationships so as to build salubrious series of events.
Pre‐intercalation of Ammonium Ions in Layered δ‐MnO2 Nanosheets for High‐Performance Aqueous Zinc‐Ion Batteries

Field: Materials Science (Physical Sciences)

Abstract Layered manganese dioxide is a promising cathode candidate for aqueous Zn‐ion batteries. However, the narrow interlayer spacing, inferior intrinsic electronic conductivity and poor structural stability still limit its practical application. Herein, we report a two‐step strategy to incorporate ammonium ions into manganese dioxide (named as AMO) nanosheets as a cathode for boosted Zn ion storage. K + ‐intercalated δ ‐MnO 2 nanosheets (KMO) grown on carbon cloth are chosen as the self‐involved precursor. Of note, ammonium ions could replace K + ions via a facile hydrothermal reaction to enlarge the lattice space and form hydrogen‐bond networks. Compared with KMO, the structural stability and the ion transfer kinetics of the layered AMO are enhanced. As expected, the obtained AMO cathode exhibits remarkable electrochemical properties in terms of high reversible capacity, decent rate performance and superior cycling stability over 10000 cycles.
IDDF2018-ABS-0209 Venous thromboembolism in patients with inflammatory bowel disease in china: investigations into incidence and risk factors

Field: Medicine (Health Sciences)

Background

Studies from the western population proved inflammatory bowel disease (IBD) a risk factor for venous thromboembolism (VTE) and thromboprophylaxis has become standard care for hospitalised IBD patients with disease flares. In Asia, lack of studies on VTE among IBD patients makes practice of thromboprophylaxis far from standardised. Our aim is to explore the incidence and risk factors for VTE among Chinese IBD patients.

Methods

Retrospective analysis of IBD patients from 17 Chinese tertiary referral hospitals between 2011 and 2016 was performed. Patients with IBD diagnosis were identified and searched for VTE diagnosis. Incidence density of VTE was calculated; a case-control study that included IBD patients with and without VTE was performed to analyse VTE related risk factors among Chinese IBD patients.

Results

A total of 8459 IBD patients and 46 patients with VTE were identified, yielding an incidence of 37.18/10000 person-years. Risk of VTE increased with advanced age (RR=1.05, 95%CI=1.02–1.08) and history of bowel resection (RR=3.52, 95%CI=1.45–8.52). Severe disease flare (Crohn's disease activity index [CDAI]>450, mayo score >10), but not disease flares with less severity (CDAI >150, mayo >2), was an independent risk factor for VTE among inpatients (for Crohn's disease: OR=11.68,95%CI=2.33–58.47, ulcerative colitis: OR=4.68, 95%CI=1.11–19.58). In addition, history of glucocorticoids use was a risk factor for patients with Crohn's disease (OR=5.01, 95%CI=1.22–21.16), whereas history of 5-aminosalicylic acid use was a protective factor for patients with ulcerative colitis (OR=0.16, 95%CI=0.04–0.65).

Conclusions

The incidence of VTE among Chinese IBD patients is not lower than that from the western population. VTE related risk factors included age, severe disease flare, past history of surgery and glucocorticoids use, whereas past use of 5-aminosalicylic acid was protective against VTE for ulcerative colitis. Thromboprophylaxis should be considered for patients with these risk factors.
Paths to utopia : anarchist counter-cultures in late Victorian and Edwardian Britain 1880-1914

Field: Arts and Humanities (Social Sciences)

Most historiography on British Anarchism has concluded that the Anarchists \ncontributed very little to the political, social and cultural life of Britain. This thesis aims to \nprovide an alternative view. The failure of Anarchism as a coherent political movement has \nbeen adequately charted by others. The purpose of the present work is to investigate the \nimpact of Anarchist ideas and practices within the wider political culture. It will \ndemonstrate that Anarchism had significant things to say about many of the issues \ntroubling British society at the end of the nineteenth and beginning of the twentieth \ncenturies. The Anarchist contribution often demonstrated a high degree of originality and \ncoherence and therefore deserves to be taken seriously. \nThe first chapter outlines the evolution of British Anarchism from the 1880's \nonwards in order to construct a chronological and organisational context for the thematic \ndebates that follow. It provides an historical account of the various Anarchist groups in \nBritain and their relations with the rest of the Socialist movement. Chapter Two builds on \nthis by discussing the various social and cultural mileux characteristic of British \nAnarchism. The following chapters present evidence of the Anarchist contribution to a \nvariety of diverse developments in British society between the 1880's and 1914. In order, \nthese are educational practices, communal ways of living, trade unionism, Syndicalism and \nfinally the status of women in society. The conclusion maintains that, although Anarchist \ninfluence was weakened by sectarianism and organisational failures, the Anarchists \nnevertheless made an original contribution to the political culture, both as theorists and \npractical activists.