jimnoneill/paper-to-field-training huggingface dataset:
RT-PCR based tyrosine kinase display profiling of canine melanoma: IGF-1 receptor as a potential therapeutic target

Field: Veterinary (Health Sciences)

1115 Introduction: Metastatic melanoma can be a devastating disease, and the optimal nonsurgical treatment remains unknown. Canine mucosal melanoma (CMM) resembles human melanoma in terms of metastatic behavior, refractoriness to standard therapy, and tumor antigen expression but it is not known how closely CMM resembles human melanoma with regard to molecular pathogenesis. There is a wealth of information available regarding tyrosine kinase (TK) expression in human cancer, however no attempt has been made to systematically define the repertoire of TKs expressed in CMM. This study employed a molecular technique called RT-PCR display to simultaneously evaluate the expression of up to 30 different TKs in a CMM cell line. Materials and Methods: mRNA was extracted and reverse-transcribed from the 17CM98 CMM cell line, then subjected to PCR using degenerate primers coding for highly conserved regions flanking the kinase domains of many receptor and nonreceptor TKs. The resulting 210-bp product was ligated into pCR-Topo2.1 and used to transform E. coli. Multiple bacterial colonies were isolated, the cDNA inserts sequenced and then compared with published sequence data using BLASTn. Results and Conclusions: Sequencing 46 clones yielded canine homologs of IGF-1R (50%), JAK1 (17%), PDGFR-a (11%), FGFR1 (9%), Axl (7%), c-Abl (4%), and PTK2 (2%). Interestingly, IGF-1R, JAK1 and Axl were detected using a similar technique in human melanoma, supporting the cross-species validity of this assay. Given the relative abundance of IGF-1R clones, we sought to determine the biologic effect of rhIGF-1 in 17CM98 cells. IGF-1 stimulated IGF-1R phosphorylation, cell proliferation and VEGF production in 17CM98, and protected the cells from serum starvation-induced apoptosis. Addition of the IGF-1R kinase inhibitor ADW742 (Novartis) abrogated all IGF-1 induced changes. Expression of IGF-1R mRNA was detected in 5 of 5 additional CMM cell lines evaluated, suggesting that IGF-1R expression may be common in CMM cells and providing a novel target for future therapy. In conclusion, this study demonstrates the applicability of the tyrosine kinase RT-PCR display technique to canine cells, suggests that a similar spectrum of TKs are expressed by human and canine melanoma, and demonstrates the efficacy of ADW742 in IGF-1R expressing canine tumor cells.
Conceptual Design of COD-E Humanoid Robots

Field: Computer Science (Physical Sciences)

The conceptualizing process plays an important role in assisting designers’ creativity in form and styling development. It contributes to representing the cultural elements before product transformation, which has a limited investigation. This research aims to identify the metaphorical form element that conveys the brain impaired as factors of selection and defining form development of the humanoid robot embodiment. Design Protocol Analysis obtains to into design linguistic interpretations and synthesizing design based on perceptual product experience. Findings have outlined the theory of metaphorical form element selection and identification that could represent brain impaired product in assisting humanoid robotic acceptance among autism. Keywords: Design-Inspire; Humanoid Robot; Children with Autism; Design Protocol Analysis. eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bsby e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v5iSI3.2534
PEMANFAATAN SANA KEBO DAN JARAK DALAM MATERI KARYA SENI TIGA DIMENSI DARI TANAH LIAT PADA SIMULASI PEMBELAJARAN INTERAKTIF SISWA KELAS INKLUSIF DI SLB NEGERI KOTA MAGELANG KELAS VI SDLB JURUSAN C

Field: Arts and Humanities (Social Sciences)

The purpose of using the sap of sana kebo and jarak is to improve the quality of three-dimensional artwork from clay materials of grade VI SDLB-C and SD students by understanding the following matters, namely: (1) introducing natural materials that are cheaper and safer for environment, (2) improving the quality of finishing three-dimensional artwork created by students, and (3) stimulating students' thinking patterns to better explore alternative materials that can be found in the natural surroundings. This best practice was carried out in class VI of Kedungsari 5 Elementary School, Magelang City and class VI SDLB-C, Magelang City. There are several variations of shapes that students can choose from, among others: (1) flora models, (2) fauna models, (3) geometric models, and (4) figurative models. The process of teaching and learningabout three-dimensional works of art with the sap of sana kebo and jarak gums as finishing material in class VI Kedungsari 5 Elementary School Magelang City and class VI SDLB-C Magelang City demonstrate the following facts: (1) the interaction between students with special needs students from regular classes are well established, this is characterized by smooth communication during the learning process and harmonious integration in several games, (2) there is no gap between students with special needs and students from regular classes in teaching and learning activities, (3) use the sap of sana kebo and jarak improve the quality of threedimensional artwork made from clay, (4) three-dimensional artwork that uses the sap of sana kebo and jarak have a more attractive appearance than without the sap of sana kebo and jarak, (5) the use of materials nature provided by the surrounding environment can be encouraged in the learning process, and (6) it is needed a more interesting learning package to increase students' imagination and creation. It can be concluded that the sap of sana kebo and jarak proved to be able to improve the quality of three-dimensional artworks of grade VI students of SD Negeri Kedungsari 5, Magelang City and grade VI SDLB-C.
Current situation of production of early and mid season apple cultivars in China and progress in breeding for early and mid season apple cultivars

Field: Agricultural and Biological Sciences (Life Sciences)

Apple is one of the most important fruits in China,but the proportion of cultivars grown and their ripening seasons are not suitable for the fruit market.The production of early and mid season cultivars is only occupied by around 15% of the total apple production,while the production of late cultivars amounts to 85% of the total production.This paper analyses the main early and mid season apple cultivars grown today and their each proportion in apple industry.Based on the achievements of apple breeding for early and mid season cultivars in the past twenty years in China the authors would suggest that more attention should be paid to early and mid season cultivar development in future,some newly-bred early cultivars are also introduced.
Herpes zoster recurrence within 1 month: A case report

Field: Medicine (Health Sciences)

Herpes zoster (HZ), caused by the varicella-zoster virus, is an infectious skin disease that rarely recurs after initial presentation. The mechanism underlying HZ recurrence is currently under investigation. In this article, we report a case of HZ relapse within 1 month. Analysis of patient’s clinical manifestations, histopathological features, and flow cytometry results indicated that the absolute and percentage values of B cells were below the lower limit. We hypothesized that the patient had abnormal humoral immune function, which may be one reason leading to the HZ relapse within 1 month. The findings of this case will serve as useful reference for HZ recurrence for clinicians. This case was impactful and added to the literature on HZ recurrence.
Overt and Covert Modes of Legitimation in East European Societies

Field: Social Sciences (Social Sciences)

The impressively growing literature on legitimation has produced not so much a further clarification of the concept as rather a number of new interpretations and an extension of the topics discussed under it. This extension has involved not only a more detailed analysis of the concrete mechanisms of the process of legitimation, but also a multiplication of the objects of legitimation: the notion of legitimacy is not applied to social systems as wholes as well as to political regimes, concrete governments and even to specific measures of governmental policy.KeywordsCivil SocietyPrivate ActivityPolitical RegimePolitical PluralismCommunist StateThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Human trafficking in the hospitality industry: Employee awareness, beliefs and training

Field: Social Sciences (Social Sciences)

Human trafficking is a growing concern in the hospitality industry. The intersect ofhuman trafficking and the lodging industry are twofold: 1) victims staying at hotels duringtransportation and 2) sexual exploitation or activity occurring at hotels. Therefore, it is importantthat hotel employees know how to recognize signs of human trafficking as signs vary from caseto case.The purpose of this study was to identify hotel employees' awareness, beliefs, andtraining regarding human trafficking. A survey was developed and pilot tested. A conveniencesample of hotel employees in the Midwest were surveyed and data were analyzed. Participantswere asked questions regarding their awareness, beliefs, and level of training related to humantrafficking in the lodging industry. Simple statistics were used to analyze the data from thecompleted surveys. Out of 118 respondents 52, (44.07%) answered that they were moderatelyaware on the topic of human trafficking. When asked how prevalent human trafficking is in thehospitality industry, 44 (37.61%) of 117 respondents answered that it was moderately prevalent;followed by 43 (36.75%) of the respondents answering it was extremely prevalent. Of 117respondents, 71 (60.68%) answered that in their current position, training on human traffickingwould be extremely beneficial.Hospitality is a global industry; thus, there is opportunity to spread awareness abouthuman trafficking to an expansive community throughout the world. It is important that hotelemployees are given ample information and training in order to help them handle situations thatinvolve human trafficking in their establishments.
Evaluation of Subjective Appetite Assessment under Free-Living vs. Controlled Conditions: A Randomized Crossover Trial Comparing Whole-Grain Rye and Refined Wheat Diets (VASA-Home)

Field: Medicine (Health Sciences)

Background: Accurate assessment of self-reported appetite under free-living conditions is warranted to conduct large-scale intervention studies measuring appetite at a feasible cost. However, the performance of visual analogue scales (VASs) for this purpose has not been widely examined. Method: This randomized crossover trial was conducted to evaluate VASs in free-living vs. clinic-based settings and to assess appetite response following hypocaloric whole-grain rye and refined wheat diets. Twenty-nine healthy adults with overweight or obesity continuously answered VAS questions about their perceived appetite from morning to evening. Results: No differences in whole-day VAS scores (primary outcome) between clinic-based and free-living settings were observed, whereas measures of total area under the curve (tAUC) showed increased fullness in clinic-based interventions of 7% (p < 0.008) for whole-day responses and 13% (p < 0.03) following a snack. Appetite responses for a whole day did not differ between diets whereas rye-based dinners induced 12% (p < 0.016) higher fullness and reduced hunger by 17% (p < 0.02) irrespective of setting. A reduction in hunger of 15% (p < 0.05) was also observed following rye-based vs. wheat-based lunches. Conclusion: The results suggest that the VAS is valid for evaluation of appetite responses between diets under free-living conditions. No difference in self-reported appetite over the whole day was found after whole-grain rye vs. refined wheat-based diets, but there were some suggested differences at certain postprandial periods, in individuals with overweight or obesity.
Elution fractionation of atactic and isotactic polypropylene

Field: Chemistry (Physical Sciences)

Abstract Procedures and an apparatus for the elution fractionation of polypropylenes are described. The isotactic polymer is precipitated onto a sand column from p ‐xylene solution by cooling slowly from 126°C. to room temperature. After removal of the solvent and the atactic fraction soluble at room temperature, the column is heated to 156°C. Fractions are eluted with mixtures of a high boiling hydrocarbon fraction as solvent and 10% ethylene glycol in 2‐butoxyethanol as nonsolvent. The dissolving power of the eluents is periodically increased to fractionate the polymer. Upward solvent flow is used. Recovery is usually quantitative, and good reproducibility is demonstrated. Polymer degradation during fractionation has been reduced to generally less than 5% by suitable techniques. Molecular weight distribution curves for three samples are shown. Good selectivity is established by the fact that the ratio of the molecular weight of the highest to that of the lowest fraction is usually in the range of 50 to 200. A description of the fractionation of atactic polypropylene is given also. The atactic material was used to show the effect of depositing the polymer selectively or randomly on the surface of the support as well as the effect of diffusion on fractionation efficiency.
[Psychological and neurologic long-term consequences of brain tumors in children. A pilot study].

Field: Neuroscience (Life Sciences)

Brain tumor is one of the most common forms of cancer in children. The therapy includes surgical interventions, radiation of the central nervous system and chemotherapy. Combining these methods of treatment has remarkably improved the survival of children with certain brain tumours (e.g. medulloblastoma). However, long-term studies have revealed serious psychological and somatic consequences of the disease and the treatment. This paper presents the results of a pilot study of nine children with brain tumor. The patients were examined using a battery of neuropsychological methods (Luria's Neuropsychological Investigation, WISC-R), a semi-structured interview (Child Assessment Schedule), a parent report form (Achenbach Child Behaviour Checklist) and a clinical neurological examination. The most striking finding from this investigation was in the psychosocial field. Except for one child, all the patients showed an introvert reaction pattern with a tendency towards anxiety, depression and social withdrawal. All the children showed some neurological and neuropsychological deficits. Except in the case of two mentally retarded children, cognitive functions were within the lower normal range. Specific learning, memory and fine-motor disabilities were found in more than half of the patients. The investigation suggested that both fine-motor and mental performance was detrimentally affected by increased speed. This seems to be an area of special interest for further studies.
Identification of canine osteoarthritis using an owner‐reported questionnaire and treatment monitoring using functional mobility tests

Field: Veterinary (Health Sciences)

Objectives To investigate the diagnostic value of an owner‐completed canine osteoarthritis screening checklist to help identify previously undiagnosed osteoarthritis cases, and assess their response to carprofen treatment by monitoring pain and functional mobility. Materials and Methods Dogs (n=500) whose owners reported ≥1 positive response to the osteoarthritis checklist were examined to identify dogs with previously undiagnosed osteoarthritis. Eligible dogs (n=133) were evaluated for pain and video mobility analysis by Helsinki Chronic Pain Index and visual analogue scale scores, respectively, following carprofen treatment, administered for 30 days (n=95) or up to 120 days (n=38). Dogs were filmed at clinics performing activities (walking, jogging, sitting/lying, walking up and down stairs), and scored at days 0, 30 and 120 using visual analogue scale by an independent blinded expert. Results A diagnosis of osteoarthritis was confirmed by a veterinarian in 38% (188 of 500) of dogs. Balance of sensitivity and specificity across the original group of nine screening questions was optimised to approximately 88 and 71%, respectively, after elimination of three questions. Pain measured by Helsinki Chronic Pain Index and functional mobility improved over time in response to treatment with carprofen. Mean ability scores for activities significantly improved between days 0 and 30 for walking, jogging, sitting/lying and walking down stairs, and days 0 and 120 for sitting/lying and walking up stairs. Clinical Significance More osteoarthritis cases were identified in study dogs than previous prevalence estimates, indicating the screening checklist's potential to help identify for further evaluation cases that could otherwise remain undiagnosed. Improvements in function were demonstrated after carprofen treatment.
Stock market predictability 2000-2014: the effect of the great recession

Field: Economics, Econometrics and Finance (Social Sciences)

The return predictability of 242 companies with continuous daily trading in the Standard and Poor's index during the 2000-2014 period is examined using rolling variance ratio tests. The results indicate that predictability is time-varying and stock-specific, a finding which is in accordance to the adaptive market hypothesis. During the great recession the number of stocks whose returns were found to be predictable increased substantially, especially during the period of Lehman Brothers bankruptcy. Importantly, predictability is found to be driven by changing market conditions, such as stock market volatility and economic fundamentals.
Equation of state experiments and theory relevant to planetary modelling

Field: Physics and Astronomy (Physical Sciences)

In recent years there have been a number of static and shockwave experiments on the properties of planetary materials. The highest pressure measurements, and the ones most relevant to planetary modelling, have been obtained by shock compression. Of particular interest to the Jovian group are results for H 2 , H 2 0 , CH 4 and NH 3 . Although the properties of metallic hydrogen have not been measured, they have been the subject of extensive calculations. In addition recent shock wave experiments on iron report to have detected melting under Earth core conditions. From this data theoretical models have been developed for computing the equations of state of materials used in planetary studies. A compelling feature that has followed from the use of improved material properties is a simplification in the planetary models.
Solanum sp. LOTID 251542

Field: Agricultural and Biological Sciences (Life Sciences)

Plant Genetic Resource.
Taxonomy: Solanum sp.
Common name(s): Potato
Other names: 2664-85
Conserved by: Centro Internacional de la Papa (CIP), Peru
Local sample unique identifier: LOTID 251542
Method of creation: In-house copy
Date: 2023
Other identifiers: n/a,CIP 005668
Historical: Yes
Biological status: Traditional cultivar/landrace
MLS status: Not included
Technology helps patients with emergency room prescriptions

Field: Health Professions (Health Sciences)

Journal Article Technology helps patients with emergency room prescriptions Get access Cheryl A. Thompson Cheryl A. Thompson Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 60, Issue 24, 15 December 2003, Page 2550, https://doi.org/10.1093/ajhp/60.24.2550 Published: 15 December 2003
Mutation analysis of the autosomal dominant Weill-Marchesani syndrome and genotype-phenotype review

Field: Medicine (Health Sciences)

Objective
To screen the disease-causing genes in an autosomal dominant(AD)Weill-Marchesani syndrome (WMS) family from Henan province in China, and to analyze the relationship between genotypes and phenotypes of the AD WMS.

Methods
A family with suspected WMS was collected and studied in Henan Eye Hospital from September 2016 to July 2017.Clinical data and genomic DNA of the families were analyzed and genetic variations were screened by whole-exome sequencing (WES) The candidate genes related to ectopia lentis (FBN1, ADAMTSL2, ADAMTSL4, TGFBR2, CBS, ADAMTS10, ADAMTS17) were analyzed, and multiplex ligation dependent probe amplification (MLPA) was applied.Novel variants were further evaluated by sequencing 96 normal individuals.The previous reports with similar genetic characteristics were reviewed and the mutation types and clinical features were summarized.Written informed consent was obtained from the participants or their guardians before the collection of their venous blood and clinical data.Ethical approval was obtained from the Institutional Review Board of Henan Eye Institute.

Results
The suspicious mutation of the c. 5260G>A was detected in exon 42 of the FBN1 by WES in this family, which was predicted to be pathogenic and cosegregated with the disease; the clinical futures of the patients in the family included proportionate short stature, brachydactyly, joint stiffness, and the ocular problems included microspherophakia, moderate myopia, secondary glaucoma.Four mutations of FBN1 that related to WMS were reported in previous literature, and three of them were located in 41-42 exons and the others were the deletion of exons 9-11.All patients had typical clinical features of microspherophakia, short stature, brachydactyly, joint stiffness.In addition, thick skin was common, heart defects were occasional, protuberant abdomen and umbilical hernia were rarely reported.

Conclusions
The affected members in this family are in according with the clinical and genetic diagnosis of WMS.A novel mutation (c.5260G>A) in FBN1 is discovered, which increases the spectrum of WMS mutation.The 41-42 exons of the FBN1 are hotspot of mutation in WMS.

Key words:
Weill-Marchesani syndrome; FBN1 gene; Whole-exome sequencing; Phenotype
Private Acts, Social Consequences: AIDS and the Politics of Public Health

Field: Social Sciences (Social Sciences)

Other| February 01 1991 Private Acts, Social Consequences: AIDS and the Politics of Public Health Ronald Bayer, Private Acts, Social Consequences: AIDS and the Politics of Public Health. New York: Free Press, 1989. 282 pp. $22.95 cloth. Mark Scherzer Mark Scherzer Search for other works by this author on: This Site Google J Health Polit Policy Law (1991) 16 (1): 184–187. https://doi.org/10.1215/03616878-16-1-184 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn Email Permissions Search Site Citation Mark Scherzer; Private Acts, Social Consequences: AIDS and the Politics of Public Health. J Health Polit Policy Law 1 February 1991; 16 (1): 184–187. doi: https://doi.org/10.1215/03616878-16-1-184 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsJournal of Health Politics, Policy and Law Search Advanced Search The text of this article is only available as a PDF. Copyright © 1991 by Duke University Press1991 Article PDF first page preview Close Modal You do not currently have access to this content.