jimnoneill/paper-to-field-training huggingface dataset:
Development and validation of stability indicating high‐performance thin‐layer chromatographic method for estimation of Rifapentine in pharmaceutical formulation

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract A simple, accurate, and precise method is described for stability indicating a high‐performance thin‐layer chromatographic (HPTLC) method for development and validation in the pharmaceutical dosage form. The method was based on HPTLC separation of the drug by measurement of the spot at 478 nm. Separation was carried out on silica gel 60GF254 by using mobile phase methanol:toluene:acetic acid (3:7:0.1, v/v/v). The linearity range was between 500–3000 ng/spot with a coefficient of determination 0.999, respectively. The retardation value found was 0.55 ± 0.02 and the % recovery was found to be 100.610 ± 0.035%–101.0178 ± 0.035%. The limit of detection value for Rifapentine was 92.901 ng/spot and the limit of quantitation for Rifapentine was found to be 281.52 ng/spot. Forced degradation studies were carried out under various conditions. In acidic conditions, the % degradation was found to be 20.07%. In alkaline and oxidative conditions, the % degradation was found to be 61.27% and 11.12%. Photolytic and thermal conditions the % degradation was found to be 49.75% and 8.35%. Maximum degradation was found in alkaline condition with 61.27%, an assay for the marketed formulation was carried out and the amount of drug was found to be 149 ± 0.05 mg with a % of 99.25% ± 0.005%.
Cytotoxic T Lymphocyte Antigen 4 Gene +49 A/G (rs231775) Polymorphism and Susceptibility to Systemic Lupus Erythematosus

Field: Medicine (Health Sciences)

Aim: To assess the probable role of +49AG polymorphism in susceptibility to SLE in an Egyptian population. Background: Systemic lupus erythematosus (SLE) is a compound inflammatory chronic disease distinguished through the release of autoantibodies. Cytotoxic T lymphocyte associated antigen-4 is a main down controller of T-cell response; its dysregulation could affect SLE pathogenesis by altered T cells activation to self-antigens. Objectives: To evaluate the CTLA-4 +49AG allelic and genotype frequency in a sample of the Egyptian population and correlate them with disease susceptibility and clinical severity. Materials and methods: Including 100 patients with SLE and 100 healthy controls (age and gender matched), CTLA-4 exon 1 49 A>G Genotyping was done using Real-Time PCR. Results: No difference was noticed in genotype or allele distributions of the studied polymorphism between both groups. Similar genotypes and allele frequencies were established for the 2 groups after their stratification by the age of disease onset, clinical course, or severity. Conclusion: CTLA-4 +49AG gene polymorphism is not linked with the liability to develop SLE in the studied Egyptian population. Yet it is significantly related to disease severity.
Bibliometric analysis and visualization of the Journal of Management & Organization

Field: Business, Management and Accounting (Social Sciences)

Journal of management & organization (JMO), which started its publication life in 1995, publishes scientific studies in the field of management and organization. This research aims to make a bibliometric analysis of 780 documents published since 2007 when JMO first started indexing in WoS. Research data were taken from the Web of Science database in plaintext format. The journal's conceptual, intellectual, and social structure was revealed by applying techniques such as co-citation, co-authoring, and co-creation through the Vosviewer software. When the research results are examined, it is seen that there is an increasing trend in the number of citations after 2007, when JMO started to be indexed in the WoS database. Research findings show that 1516 authors contributed to the JMO, with "Tui Mckeown" being the most prolific author with fifteen documents. A total of 651 universities contributed to the JMO during the period under review. The top contributing university is Griffth University, with 38 papers. The country that has contributed the most to the JMO since 2007 is Australia, with 241 documents. "Leadership" is the most used keyword in the journal. "Academy of Management Journal" is the most used journal in the documents sent to the journal. The fact that the journal does not comply with Lotka's law and the studies with multiple authors are more than single studies means that the cooperation between the authors is strong.
Angora: Efficient Fuzzing by Principled Search

Field: Computer Science (Physical Sciences)

Fuzzing is a popular technique for finding software bugs. However, the performance of the state-of-the-art fuzzers leaves a lot to be desired. Fuzzers based on symbolic execution produce quality inputs but run slow, while fuzzers based on random mutation run fast but have difficulty producing quality inputs. We propose Angora, a new mutation-based fuzzer that outperforms the state-of-the-art fuzzers by a wide margin. The main goal of Angora is to increase branch coverage by solving path constraints without symbolic execution. To solve path constraints efficiently, we introduce several key techniques: scalable byte-level taint tracking, context-sensitive branch count, search based on gradient descent, and input length exploration. On the LAVA-M data set, Angora found almost all the injected bugs, found more bugs than any other fuzzer that we compared with, and found eight times as many bugs as the second-best fuzzer in the program who. Angora also found 103 bugs that the LAVA authors injected but could not trigger. We also tested Angora on eight popular, mature open source programs. Angora found 6, 52, 29, 40 and 48 new bugs in file, jhead, nm, objdump and size, respectively. We measured the coverage of Angora and evaluated how its key techniques contribute to its impressive performance.
MOESM1 of Determinants of poorly controlled asthma among asthmatic patients in Jimma University Medical Center, Southwest Ethiopia: a case control study

Field: Medicine (Health Sciences)

Additional file 1. Individual anti-asthmatic and concurrent medication related factors among asthmatic patients who have follow up at Jimma University Medical Center. This data shows anti-asthmatic and concurrent medication pattern among asthmatic patients in Jimma University Medical Center.
Analytical Studies and Biological Activity of New Azo Dye and Its Complexation with Zinc

Field: Chemistry (Physical Sciences)

Azo dye (AD), (Z)-5-amino-2-(((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl) phenyl) sulfonyl) diazenyl) phenol) and its complex with zinc were prepared and characterized using FTIR, UV-visible, elemental analysis and mass spectrum. Analytical studies showed that this dye had high solubility in ethanol and gave three isopiestic points when studying the pH effect in a range of buffer solutions. The protonation constants pKb1 and pKb2 of nitrogen atom and the ionization constant pKa of OH-group were equal to 3.4, 7.26 and 10.5 respectively. These results indicated the suggested ionization scheme in acidic and basic media. Further, the synthetic AD was provided non-toxic effects using different concentrations, and did not show any heamolysis effects in the cells in contrast with another chemical compound. The new AD is considered as novel medicine or chemical sanitizer. Further, the biological activity of AD and its complex was tested against four different bacteria, (Staphylococcus Aureus, Escherichia Coli, Bacillus Cereus and Pseudomonas Aeruginosa) and two different fungi (Aspergillus Albicans and Candida Albicans). The results showed that the complexation of AD with zinc was decreased the biological activity of synthetic AD.
POS-772 SHEAR WAVE BASED ELASTOGRAPHY POINT QUALIFICATION IN THE EVALUATION OF RENAL PARENCHYMA STIFFNESS IN KIDNEY TRANSPLANT RECIPIENTS UNDERGOING GRAFT BIOPSY

Field: Medicine (Health Sciences)

Shear wave elastography (SWE) is an ultrasound technique that measures tissue stiffness non-invasively. In SWE, a real-time short-duration acoustic push pulse generates shear waves travelling perpendicular to the main US beam. Renal biopsy remains the gold standard in assessing rejection and chronicity in kidney transplantation. However, biopsy remains imperfect, with limitations and inherent risks, including sampling errors, allograft trauma with multiple needle pass attempts, and significant interobserver variation in interpreting biopsy samples among pathologists.
The generation of nanostructures on ZnO/Si surface

Field: Materials Science (Physical Sciences)

Nanoscale one-dimensional (1D) semiconductor structures such as rods, tubes and wires have attracted much attention recently. ZnO nanorods are important because of their unique 1D structure with a direct wide band gap of 3.37eV and a large exciton binding energy of 60 meV at room temperature. These unique properties make it a promising material for applications in electronics, solar cells and other nanoscale optoelectronic devices. The purpose of this Final Year Project is to generate nanostructures on the surface of pre-coated silicon substrate. Precursor solution was prepared by mixing of Zinc Nitrate Hexahydrate and Hexamethylenetetramine in deionized (DI) water. Many factors like precursor solution concentration, reaction time and reaction temperature which have impact on the generation process of the nanostructures were introduced. The effect of these factors was discussed in the report in order to study the microstructure and optical properties of ZnO nanostructures. By using low temperature hydrothermal method, ZnO nanorods have been successfully generated under different conditions. Scanning Electron Microscope (SEM), X-ray Diffraction (XRD) and Photoluminescence (PL) spectroscopy were used to characterize the microstructure features, crystal structures and chemical compositions of the ZnO nanostructures. The results show the diameter and length of the ZnO nanorods increase upon increasing the precursor concentration, reaction time and reaction temperature. It was found that the preferred orientation growth of the wurtzite structure of ZnO nanorods was along [0001] direction. The optical property of the ZnO nanorods was also studied by PL analysis. The measurement from the current-voltage (I-V) curve indicates the ideal diode characteristic performed by each ZnO/GaN nano-heterojunction. The success in the fabrication of a great number of fully ordered individual p-n nanojuctions are expected to provide the potential application for high density and efficient nano-devices, such as photovoltaic devices.
Predictive and Protective Role of Grit, Internal Locus of Control and Social Support in Mental Health of Cardiac Patients

Field: Psychology (Social Sciences)

Individuals diagnosed with cardiac diseases often experience poor mental health outcomes. However, grit, social support and internal locus of control can provide protective effects against poor mental health in patients diagnosed with cardiovascular diseases. The purpose of the present study was to assess the predictive and protective role of grit, internal locus of control and social support with regard to mental health of cardiac patients. A total of 250 cardiac patients had been sampled comprising 130 males and 120 females in the age range of 30 to 70 years selected through purposive sampling. Data collection was done using Rotter's Locus of Control Scale, Multidimensional Scale of Perceived Social Support, Duckworth Grit Scale and DASS-21. Data analysis was done using Pearson correlation and regression analyses using dummy coding. Results showed that among cardiac patients, being a male in the age range of 30 to 45 years of age, being married, having higher levels of education, higher scores on grit with an internal locus of control is associated with improved mental health. It is thus concluded that having an internal locus of control, higher levels of social support and being gritty is associated with improved mental health outcomes in cardiac patients.
Flight Plan

Field: Arts and Humanities (Social Sciences)

150 years after Sir George Cayley’s historic first manned flight in Yorkshire Jen Southern will be making a flight as the pilot of a Cessna 150. Using a GPS device to track her route she will make a drawing of a plane from a flight simulation. This work is one of many journeys made by the artist which play games with definitions of virtual and real. \n \nThis work is part of a research project funded by Arts Council of England, Yorkshire in which Jen is simultaneously learning to fly a light aircraft and a flight simulation game.The performance may be seen briefly from the ground under the flight path between 1 pm and 2.30pm , or on take off and landing at the airfield. The drawing will later be available in printable format on the web.
Steady-state acid-base response at exercise levels close to maximum lactate steady state

Field: Medicine (Health Sciences)

OBJECTIVE: To study acid-base status during a constant-load treadmill test at exercise levels close to the maximum lactate steady-state. DESIGN: Two tests were performed: one maximal and one steady-state at a load corresponding to the mean of the two ventilatory thresholds observed in the first test. SETTING: University Sports Science Laboratory. PARTICIPANTS: Twenty-three male Sports Science students, aged 26.7 (+/- 4.9 SD) years, 176.1 (+/- 6.3) cm in height, and weighing 72.8 (+/- 6.7) kg. MAIN OUTCOME MEASURES: Capillary blood gases, metabolites, electrolytes. RESULTS: Acid-base status variables declined significantly during the maximal test. Lactate concentrations were above the values observed at onset of blood lactate accumulation. All the blood variables did not vary significantly at the various experimental times, except pH values and PCO2 values. Bicarbonate concentration remained constant. Plasma potassium, chlorine and sodium concentration did not increase. CONCLUSION: During a steady-state test at a load corresponding to approximately 80% of VO2max, the acid-base status in capillary blood remained constant even though the lactate concentration was over 4 mmol/L. However, despite the maintenance of a constant acid-base status, other physiological variables did not behave in the same fashion.
Metaphor and World-Conceiving

Field: Arts and Humanities (Social Sciences)

This chapter begins with a discussion of the notions of worldviews and pattering. It then sets out the focus of the book, namely the creation of worldviews: that is, with the way we create them, the way we introduce them, maintain them, and transform them. The goal is to invite readers into the kind of intellectual adventure that translators set off upon when they enter into foreign worldviews; because translators must inhabit more than one ‘world’, if they are to be able to build bridges between worlds with their translations. An overview of the subsequent chapters is also presented.
Angular function for the Compton scattering in mildly and ultra relativistic astrophysical plasmas

Field: Physics and Astronomy (Physical Sciences)

Compton scattering of low-frequency radiation by an isotropic distribution of (i) mildly and (ii) ultra relativistic electrons is considered. It is shown that the ensemble-averaged differential cross-section in this case is noticeably different from the Rayleigh phase function. The scattering by an ensemble of ultra-relativistic electrons obeys the law p=1-cos(alpha), where alpha is the scattering angle; hence photons are preferentially scattered backwards. This contrasts the forward scattering behaviour in the Klein-Nishina regime. Analytical formulae describing first-order Klein-Nishina and finite-electron-energy corrections to the simple relation above are given for various energy distributions of electrons: monoenergetic, relativistic-Maxwellian, and power-law. A similar formula is also given for the mildly relativistic (with respect to the photon energy and electron temperature) corrections to the Rayleigh angular function. One of manifestations of the phenomenon under consideration is that hot plasma is more reflective with respect to external low-frequency radiation than cold one, which is important, in particular, for the photon exchange between cold accretion disks and hot atmospheres (coronae or ADAF flows) in the vicinity of relativistic compact objects; and for compact radiosources.
New palaeomagnetic constraints on the position of central Bohemia during Early Ordovician times

Field: Earth and Planetary Sciences (Physical Sciences)

Apparently conflicting data within the palaeomagnetic database suggest that Bohemia was at much shallower palaeolatitudes than the Armorican and Iberian massifs in Ordovician times. In order to resolve this controversy a palaeomagnetic study of Arenig and Llanvirn volcanic and sedimentary rocks from the Barrandian Basin, Central Bohemia has been carried out. This basin comprises a sequence of unmetamorphosed Lower Palaeozoic rocks, the main folding of which occurred in Late Devonian to Early Carboniferous times. The samples collected (17 sites, 153 samples) were subjected to stepwise thermal and alternating field treatment. Eleven sites yielded reliable magnetic directions, with analysis of the results using standard principal component and great circle analyses. Up to three directions of magnetization can be identified in these rocks. The first, termed A, is generally removed below 200°C, although in some cases it persists up to 450°C in the volcanic rocks. It is approximately parallel to the present-day Earth's magnetic field in the study area (Dec/Inc 360°/67°) and is thus thought to be of recent origin. The second direction identified, termed B, is isolated at intermediate blocking temperatures (150–350°C), and yields an overall <it>in situ</it> mean direction of 195°/8°, <it>k</it> = 22.3, α<inf>95</inf> = 13.1° (seven sites). These directions fail the fold test of McFadden (1990), and correspond to a palaeopole position of 34°S; 356°E. This coincides with the Late Carboniferous sector of the European apparent polar wander path, and thus the B direction is interpreted as being a secondary overprint of this age. The highest blocking temperature direction, termed C, is identified at temperatures between 350° and 450–600°C. It passes the fold test, resulting in an overall mean direction of 312°/83°, <it>k</it> = 21.9, α<inf>95</inf> = 14.6° (six sites) after bedding correction. This direction is interpreted as being representative of the Early Ordovician palaeomagnetic field direction in the Bohemian Massif and yields a palaeopole position of 58°N; 355°E. This translates into palaeolatitudes of 76°S for Bohemia, thus demonstrating that the Bohemian Massif was at similar peri-polar latitudes to the rest of Armorica during Early Mid-Ordovician times, and formed part of the northern margin of Gondwana.
THE COMPARISON OF APPLICATION OF STOCK RETURN EVALUATION IN RECORDED COMPANIES IN LQ 45 FOR THE 2012-2016 PERIOD

Field: Economics, Econometrics and Finance (Social Sciences)

The purpose of this study is not only to compare the Capital Asset Price Model, Arbitration Price Theory, Three Factor Price Model, Three Factor Price Model, and Five Factor Price Model to study the Capital Asset Price Model, Price Arbitration Price Theory, Three Factor Price Model, Four Factors Pricing Model and Five Factors Pricing Model for excess returns and for determining the best asset pricing model in terms of the ability to explain estimates of excess returns. This research includes explanatory research (explanatory research), namely looking at the relationship between research variables and testing hypotheses that have been formulated previously. This study examines the effect of variables in the asset pricing model and compares the asset pricing models in explaining excess returns. Based on the results of the research that has been carried out the best model that can be used in assessing the asset pricing model is the five Price Model Factors, this is evidenced by the value of R2 or R Square of 89.4%, the value is greater than the value of R2 or R Square Capital Asset Pricing Model, Arbitration Price Theory, Three Price Factor Models, and Four Price Factor Models, which were 34.7%, 55.2%, 77.2% and 79% respectively.
"I think I saw a ghost": The potential for fright tourism in the city of João Pessoa – PB

Field: Social Sciences (Social Sciences)

Historic centers are plural spaces with memories of great importance to the cultural identity of a people. Besides their cultural and heritage importance, these spaces are ideal for entertainment, specifically, for the development of fright tourism, due to their dark narratives. Fright tourism can be understood as a process in which elements of local tradition are mixed with transnational aesthetics, coming from cinema, pop culture, horror, and cultural industries, promoting feelings of fear for tourists. In this context, this study aims to analyze the potential for the promotion of fright tourism, based on stories of hauntings at historical attractions in the city of João Pessoa-PB. This study is characterized as descriptive and exploratory, based on the collection of bibliographic and documentary data and a field visit. The results show that the Sólon de Lucena Park, the Santa Roza Theater and the Boa Sentença Cemetery have stories such as the ghost woman of the Lagoa, the vigilante spirit, the woman in white, the bride who walks among the tombs and the Boa Sentença employee, which permeate the popular imagination and can be used to promote fright tourism.
St Bartholomew The Great

Field: Arts and Humanities (Social Sciences)

St Bartholomew The Great Priory Church is the oldest church in London dating from 1123. It includes many original Medieval features, located near Smithfield Market it is one of London's greatest secret treasures. It has been used in multiple movies including 'Four Weddings And A Funeral' and ' Avengers Age Of Ultron'. The church is open to visitors, usuall from 8:30am and costs £5. https://en.wikipedia.org/wiki/St_Bartholomew-the-Great 1. 4800 photos taken in March 2019 with a Sony a6000 and processed in Agisoft Metashape. 2. Reprocessed in April 2020 in Agisoft Metashape to improve mesh and texture quality. Processed on PC with 2 x GTX1080ti GPU, intel i9-9900X cpu, 128gb Ram. Alignment (medium quality): 4 hours. Depth Maps (medium quality): 4 hours. Mesh: 11 hours 30 mins. Texture (after poly reduction): 15 mins. Source: Objaverse 1.0 / Sketchfab
Iterative Discovery of Multiple Disjoint Paths in Switched Networks with Multicast Frames

Field: Computer Science (Physical Sciences)

Routing via multiple paths offers many advantages such as traffic separation, congestion reduction and quality of service policies in enterprise, campus and data center networks. Disjointness of the multiple paths may provide extra benefits like increased reliability and improved traffic separation. We propose DMDP, a layer two protocol that discovers multiple disjoint paths in a switched network by exploration of the network with multicast frames. DMDP provides fast discovery of node-disjoint or link-disjoint paths, selecting the fastest disjoint paths available without any route computation over the network graph. Paths obtained by DMDP are similar to the multiple paths computed with a k-shortest path algorithm, but much simpler to find. Multiple disjoint path search may be implemented as a proactive, reactive on-demand or hybrid service at edge switches.