jimnoneill/paper-to-field-training huggingface dataset:
Emerging from the haze: A psycho-educational series to combat cognitive complaints after cancer treatment.

Field: Health Professions (Health Sciences)

230 Background: Cognitive dysfunction after cancer treatment can be distressing and may profoundly impact quality of life, feasibility of returning to work, and social reintegration. Meaningful, evidence-based options for cancer-related cognitive changes are limited and urgently needed. A standardized rehabilitation program targeting common cognitive problems faced by cancer survivors may represent a safe, low-cost, effective treatment that can be easily disseminated. Emerging from the Haze (Haze) is a 6 week multi-disciplinary clinical program that provides a psycho-educational series to patients who are experiencing changes in cognition or having difficult adjustment after cancer diagnosis or treatment. The Haze course covers topics including: mood and stress management, mindfulness meditation, countering negative automatic thoughts, compensatory strategies for attention, memory, and executive functioning/problem solving, pacing and balance in addition to wellness issues related to cognition such as sleep hygiene, nutrition, social isolation, and exercise. The purpose of this research was to assess changes in the Functional Assessment of Cancer Therapy Cognitive Scale (FACT-Cog) scores immediately after the intervention and at regular intervals until the 1 year mark. Methods: Patients were given questionnaires including the FACT-Cog on the first day of the Haze series. The FACT-Cog includes the following domains: Perceived Cognitive Impairment (PCI), Perceived Cognitive Abilities (PCA), and Impact on Quality of Life (QOL). The survey battery was repeated on the last day of the series, 3 months, 6 months and 1 year after the series. Results: Based on the first 110 patients with various cancer types that have completed Haze, highly statistically significant improvements have been found in PCI (p < 0.001; Mean Δ = 8.71), QOL (p < 0.001; Mean Δ = 2.09), and PCA ( p < 0.001; Mean Δ= 2.83) based on a before and after comparison of the FACT-Cog. Conclusions: It appears that a multi-disciplinary psycho-educational clinical program to address cognitive changes and adjustment difficulties after treatment can have a positive effect on patients’ perceived cognitive functioning as measured by FACT-Cog.
The cDNA cloning and sequence about tissue inhibitor of metalloproteinase-1 from human breast cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Objective: In order to expression the cDNA of tissue inhibitor metalloproteionase (TIMP-1) in eukaryotic cell. Method: Total RNA were isolated from human breast cancer cells and cDNA encoding tissue inhibitor metalloproteionase (TIMP-1) was amplified by the reverse transcription PCR(RT-PCR). The cDNA was inserted into vectors PET-19b and the cloning vector PET19bTIMP-1 was constructed. The cDNA was identified by restriction endonucleases and sequenced. Result: It was found to differ in nucleotide as compared to the cDNA sequence(Andeson,et al,1999).This changes cause amino acid substitution at position 361 where a Thr changed into a Ala. This cDNA encodes 207 amino acids whose length is 624bp. Conclusion: The recombinant cloning vector pET19bTIMP-1 was successfully constructed in our Labs. The single gene mutation did not influence the antigen-expression.
Kant: On willing maxims to become laws of nature

Field: Arts and Humanities (Social Sciences)

An Old and continuing tendency amongst critics of Kant's thought on ethics has been to maintain that since the categorical imperative merely provides a formal condition for the rightness of actions – that the principle of the action be universalizable without contradiction – it is inadequate as a test for the rightness of actions. Such critics as Hegel, Mill, and recently, R.P. Wolff, have suggested the same fundamental objection to Kant's doctrine: the requirement that a maxim be universalizable is formally compatible with any action whatsoever being right.
Lysionotus fengshanensis Yan Liu & D. X. Nong sp. nov. (Gesneriaceae) from Guangxi, China

Field: Agricultural and Biological Sciences (Life Sciences)

Lysionotus fengshanensis Yan Liu & D. X. Nong, a new species of Gesneriaceae from Guangxi, China, is described and illustrated. Lysionotus fengshanensis is very similar to L. longipedunculatus (W. T. Wang) W. T. Wang, but differs by the peduncle being 2–4 cm long and purple, corolla campanulate, 2.5–3.0 cm long, 1.5–1.7 cm in diameter at the mouth, filaments slightly geniculate near the middle, apex of filaments with gland and staminodes 3.
Evolution of differential renal function after acute pyelonephritis

Field: Medicine (Health Sciences)

99mTc dimercaptosuccinic acid (DMSA) renal scans can provide accurate diagnosis of acute pyelonephritis, its sequelae (renal scars) and differential renal function (DRF). The purposes of this retrospective study were (1) to assess the relationship between DRF obtained during acute pyelonephritis and at follow-up, and (2) to elucidate the value of initial DRF in predicting subsequent renal scars. A total of 47 children were enrolled. All had both unilateral acute pyelonephritis diagnosed by initial DMSA renal scans, and follow-up DMSA renal scans. We found the correlation between initial and follow-up DRF poor (adjusted R2 = 0.396). Whether or not renal scars developed determined the follow-up DRF. Vesicoureteral reflux was significantly more common in children who developed renal scars. In addition, the higher the grade of vesicoureteral reflux, the lower the follow-up DRF and the improvement in DRF. When using a DRF of 46 % as the cut-off value to predict subsequent renal scars, the sensitivity and specificity were 47.8 % and 83.3%, respectively. Owing to the low sensitivity, initial DRF is not suitable for predicting the occurrence of renal scars. ( # 2002 Lippincott Williams &amp; Wilkins)
Mechanism research of human T cells stimulated by ABPS that lead to protein expression of IFN-γ and IL-4

Field: Immunology and Microbiology (Life Sciences)

Objective:To study the immunity modulation mechanism of Achyranthes bidentata polysaccharides.Methods:The T cells freshly isolated in 24 well flat bottom plates cells were cultured with serially diluted ABPS for 48 h or with 400 μg/ml ABPS for various time at 37℃ in 5% CO 2.Supernatants were assay for IFN γ and IL 4 using ELISA kit.Results:①IFN γ protein levels were continued to increased together with the increasing concentration of ABPS. IFN γ protein levels were most when the concentration of ABPS is 400 μg/ml(P0.05). But IL 4 protein levels were always low compared with that of control group(P0.05). ②T cells were cultured with ABPS for 8,18,24 h and 48 h, IFN γ protein was continued to increase, IFN γ protein levels at 24～48 h elevated fast ,and at 48 h significantly compared with that of other time(P0.001).But IL 4 protein levels were also always low compared with that of control group(P0.05).Conclusion:①ABPS can induce secretion IFN γ protein, and the effect is time and dose dependent, and ABPS can anti induce the expression of IL 4 protein. ②ABPS may up regulate Th1 type cytokine expression and down regulate Th2 type cytokine expression at protein level. [
Taxonomic Entomology in the U. S. Department of Agriculture

Field: Agricultural and Biological Sciences (Life Sciences)

Taxonomic entomologists of the U. S. Department of Agriculture (USDA) and those of the Smithsonian Institution's U. S. National Museum (Museum) have worked together so closely and effectively for so many years that they are widely, albeit erroneously, considered to be one organization: Entomology at the National Museum. A recent issue of the BULLETIN OF THE ENTOMOLOGICAL SOCIETY OF AMERICA (December 1963) carried a review of the current personnel and the collections of the Museum's Department of Entomology (formerly Division of Insects). The present paper is in part a companion article, with a review of the taxonomic unit of USDA's Insect Identification and Parasite Introduction Research Branch. It has also seemed appropriate to review the long history and contributions of USDA in taxonomic entomology, with particular reference to the organization in Washington. Inevitably, much of the historical account must include some history of entomology in the National Museum, especially for the many years in which USDA and Museum entomology were so closely interwoven that they were actually joined in the person of an individual who was at once Chief Entomologist for USDA and Curator of Insects for the Museum. From that beginning, cooperation between USDA and Museum has been closely knit and has been directed toward the common objective of developing the national collection of insects for study and reference.
Safe and Fuel-Efficient Voyage Planning for the Northeast Passage by Combining Reliable Ship Performance, Weather and Ice Forecast Models

Field: Engineering (Physical Sciences)

Abstract The Northeast Passage in the Arctic between Europe and Asia offers a significantly shorter voyage compared to the Southern route through the Suez Canal. In 2017, the EU research project “Safe maritime operations under extreme conditions: the Arctic case (SEDNA)” was established to perform a comprehensive analysis of Arctic transit shipping and to promote technical solutions for this purpose. This paper is based on the deliverables of the SEDNA project. A voyage planning tool (VPT) for Arctic applications was developed to plan the optimal route regarding ship’s fuel consumption and safety. One of the most advanced metocean and ice forecast model is utilized to provide comprehensive environmental conditions that are synchronized and will be updated frequently during the voyage. The ship energy system model takes into account the various environmental variables as well as ship’s operational conditions to compute the ship performance in both open and ice infested waters. For Arctic operations, specific ice resistance models are implemented in the VPT, and a user has the options of either relying on icebreaker assistance or going for unassisted navigation in part of the entire Arctic passage. Case study voyages of different ship types, route options, staring time, home/destination ports are simulated to demonstrate how various optimal routes are planned and how the transit time and fuel consumption vary. This information is considered being crucial for ship owners for planning their voyages in advance. The continuously updated voyage information from the VPT is particularly helpful for the ship crew if there are specific ship operations and risk mitigation actions that need to be taken care of during the voyage. In addition, this study underlines that a safe and fuel-efficient Arctic passage requires viable voyage planning tools that combine reliable ship performance with weather and ice forecasts.
Out of the Fog - Applying biomolecular methods to explore the south Scandinavian Stone Age

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The present thesis is composed of three projects, which share the theme of using minimally \ndestructive state-of-the-art scientific methods to study objects from the Early Mesolithic and the \ntransition to the Neolithic in Southern Scandinavia. \nFirstly, Zooarchaeology by Mass Spectrometry (ZooMS), protein sequencing by liquid \nchromatography tandem mass spectrometry (LC-MS/MS) and direct accelerator mass \nspectrometry (AMS) radiocarbon dating were used to interrogate barbed bone points. The results \nreveal that these iconic artefacts can be used as proxies for species utilisation and availability. \nSignificantly, a radiocarbon hiatus at 10.2 ka was discovered which implies a depeopling event \noccurred. \nThe second project focuses on very rare osseous finger ring. Direct dating of 70 proximal finds \nfrom the site places the ring at the cusp of the Neolithic. ZooMS and LC-MS/MS revealed that \nthe ring is made from red deer (Cervus elaphus), and the generated proteome may give an \nindication of the skeletal element from which it was made. \nThe last study utilises a novel finds category (masticated birch pitch) as a new source of ancient \nhuman DNA. Shotgun sequencing generated an entire human genome (2.3x) of the person who \nchewed the pitch. Interesting, she showed genetic affinity to Western Hunter-Gatherers and not \nNeolithic farmers. Additionally, metagenomics allowed the investigation of her oral microbiome, \nlatent viral diseases and diet.
A phase II trial of AZD1775 plus carboplatin-paclitaxel in squamous cell lung cancer (SqCLC).

Field: Medicine (Health Sciences)

8545 Background: In pre-clinical studies, WEE1 inhibitors have displayed synergy with cisplatin in lung cancer cell lines. Adavosertib (AZD1775) is an orally available inhibitor of the WEE1 kinase with platinum-doublet combination RP2D of 225 mg twice daily (BID) on days 1-3 (5 doses) of a 21-day cycle with the most common adverse events being bone marrow toxicity, diarrhea, vomiting, and fatigue. This phase II, single-arm, single-institution trial of carboplatin, paclitaxel, and AZD1775 was conducted at Moffitt Cancer Center ( NCT02513563 ). Methods: Patients with advanced/metastatic SqCLC who had not previously received platinum or paclitaxel for metastatic disease were enrolled. Previous use of immune checkpoint inhibitors or vaccines was allowed. Patients were treated with carboplatin AUC5 and paclitaxel 175 mg/m2 plus AZD1775 PO 225 mg once daily for one day and BID for two days for a total of 5 doses over days 1-3 of a 21-day cycle for up to 6 cycles, followed by AZD1775 maintenance until disease progression, intolerance or withdrawal. The primary endpoint was PFS. Secondary endpoints included overall survival (OS), duration of response (DoR), duration of stable disease (DSD), and disease control rate (DCR). Outcomes were measure using 80% CI obtained from Kaplan-Meier estimator, with the lower bound corresponding to a one-sided 90% CI, to test whether the median PFS exceeds 4.0 months at α = 0.10. Results: Between 10/2015 and 09/2021, 42 patients were enrolled, and 41 received at least one of the planned treatments. Baseline characteristics included : median age 66 (range, 38-82), 66% male, 93% White, 90.2% Non-Hispanic, 90% ever smoker, 85% ECOG PS 1, and 44% with negative tumoral PD-L1 expression. Among the 41 patients, 32 were evaluable for response assessment. The median PFS was 4.8 months (80%CI, 4.1 to 5.7), and the median OS was 7.3 months (80%CI, 6.4 to 8.5). The DCR was 60.9 % (14 partial responses, 11 with stable disease), with a median DoR of 4.44 months (80%CI, 3.25 to 6.94), and a median DSD of 3.5 months (80%CI, 3.0 to 4.9). Adverse events (AEs) occurred in 36 of 41 patients (88%), including grade 3 AEs in 39% patients. The three most common AEs with the combination therapy were fatigue (61%), diarrhea (51%), and nausea (49%). Drug interruptions or delays occurred in 17 patients (41%). Conclusions: The study met its primary endpoint with a median PFS of 4.8 months with the combination of Adavosertib with carboplatin and paclitaxel. However, the study regimen achieved similar response rates and median PFS of platinum-doublet combination when comparing to historical data from phase II/III trials. Although the combination was safe, over a third of patients experienced grade 3 AEs, and 10% required dose reductions or delays due to AEs. Clinical trial information: NCT02513563 .
Correcting for large vessel contamination in dynamic susceptibility contrast perfusion MRI by extension to a physiological model of the vasculature

Field: Medicine (Health Sciences)

Purpose Dynamic susceptibility contrast (DSC) perfusion images are contaminated by contributions from macro vascular signal arising from contrast agent within the larger arteries that do not contribute directly to the local tissue perfusion. Methods A vascular model of the DSC perfusion signal was extended by the inclusion of a macro vascular component based on the arterial input function. This was implemented within a Bayesian nonlinear model‐fitting algorithm that included automatic model complexity reduction. Results were compared with existing methods that do not correct for the macro vascular contamination as well as an independent component analysis technique. Results Macro vascular signal was identified in regions corresponding to larger arteries resulting in reductions by 62% within a region of interest identified with high contamination. Whereas visually similar results could be achieved with independent component analysis, it resulted in reductions in global tissue perfusion and was not robustly applicable to patient data. Conclusion A model‐based strategy for correction of macro vascular contamination in DSC perfusion images is feasible, although the model may currently need extending to more accurately account for nonlinear effects of contrast agent in large arteries. Magn Reson Med 74:280–290, 2015. © 2014 Wiley Periodicals, Inc.
Ultra-Deepwater Blowout Well Control Analysis under Worst Case Blowout Scenario

Field: Engineering (Physical Sciences)

Abstract For offshore wells, the regulatory agency requires the submission of a worst discharge analysis and relief well planning report. The ability to control the blow out under worst case blowout scenario shall be documented and is a requirement for the operators to successfully apply for a permit to drill in the US offshore fields. As the water depths of offshore drilling operations are getting deeper and deeper, due to the increased frictional pressure losses in kill lines and formation fracture strength, bringing the blow out well under control with worst case discharge becomes more challenging. Operational parameters need to be carefully controlled to avoid exceeding the operational limitations such as breaking the formation or exceeding available pump capacity. In this study, dynamic simulations of multiphase flow are carried out to evaluate the operational parameters during the kill process. The simulations account for transient changes including frictional pressure losses, U-tube effect and fluid density variations. By optimizing the operational sequence with regards to, kill mud density, pump flow rate, pump down staging, relief well drillstring and trajectory, blowout can be controlled without exceeding the operational window. The paper shows the required volumes of the kill mud, required pump capacity, optimal flow rate arrangement, and minimum time required to get full kill mud return to the sea floor during the well kill operation. Through the aid of advanced transient software models, assessment of the required capacity to kill a blowout enables development of realistic contingency plans to ensure that well control can be re-established in case of an ultra-deep water worst blowout scenario.
Cellular changes in the gill of saul (Channa striatus) grow-out fed with various dietary fats

Field: Agricultural and Biological Sciences (Life Sciences)

Various fats were assessed for their impact on the gill of saul (Channa striatus). The grow-out (av. wt. 27.36±0.09 - 32.54±0.41g) were fed for 12-weeks with six diets and a control, F7 (NATFO). F1 (L3HUF) contains 0.5% n-3 fatty acid & 7.5% saturated oil; F2 (H3HUF) contains 1.0% n-3 fatty acid & 7.0% saturated oil; F3 (MUSOL) contains 8.0% mustard oil; F4 (LINOL) contains 8.0% linseed oil; F5 (MIXOL) contains 4.0% mustard oil and 4.0 % linseed oil; F6 (SATOL) contains 8.0% saturated oil. The F-1, fed fishes showing knob-like swelling in primary gill lamella (PGL); F-2, showing swelling cartilaginous cells (CC); F-3, showing knob like swelling and cartilaginous cells; F-4, showing fusion of PGL, Secondary Gill Lamella (SGL) and CC; F-5, showing prominent CC and F-6, showing fusion of epithelial cells of PGL and SGL and CC. Gills of C. striatus fed with natural food showing normal PGL and SGL. It was summarized that addition of different fats had some impact in the gill structure (not useful in human food), however, cheaper fat source could be used for better growth and also to reduce the feed cost for aquaculture of this fish.
Influence of Metal Ions on the Structural Complexity of Mixed-Ligand Divalent Coordination Polymers

Field: Chemistry (Physical Sciences)

The reactions of the angular ligand 4,4′-oxybis(N-(pyridin-3-yl)benzamide) (L1) and 1,4-naphthalenedicarboxylic acid (1,4-H2NDC) with divalent metal salts yielded three distinct coordination polymers (CPs): {[Zn2(L1)(1,4-NDC)2]·MeOH}n, 1, {[Cu(L1)(1,4-NDC)(H2O)]·3H2O}n, 2, and {[Cd(L1)(1,4-NDC)]·2H2O}n, 3. Complex 1 features a 2-fold interpenetrated 3D framework with the (412·63)-pcu topology, while complex 2 reveals a 1D triple-strained helical chain and complex 3 displays a 3-fold interpenetrated 3D framework with (66)-dia topology. Additionally, the reactions of the flexible ligand N,N′-bis(3-methylpyridyl) adipoamide (L2) afforded {[Co4(L2)0.5(1,4-NDC)3(H2O)3(µ3-OH)2]·EtOH·2H2O}n, 4, {[Zn2(L2)(1,4-NDC)2]·2CH3OH}n, 5, and [Cd(L2)(adipic)(H2O)]n (H2adipic = adipic acid), 6, exhibiting a self-catenated 3D framework with the (420·68)-8T32 topology, a 2D layer with the (413·62) − (4,4)IIb topology, and a 2D layer with the (44·62)-sql topology, respectively. The structural diversity observed in complexes 1–6 highlights the pivotal influence of the metal center on the degree of entanglement in CPs within mixed-ligand systems. The thermal stability and luminescent properties of complexes 1–3, 4, and 6 are also discussed.
Japan and Kabuki at the Zenith

Field: Arts and Humanities (Social Sciences)

Abstract This chapter discusses events surrounding the world of kabuki in 1942. Among these is Japan's noble, civilizing mission in China and the Pacific; its use of theater as cultural propaganda; arrival of some twenty new plays to kabuki stages, stimulated by public excitement over the nation's stunning military successes; and the Bureau of Information's focus on three major initiatives that affected kabuki: it began to support Theater for the Masses, it continued to urge kabuki troupes to stage Citizens' Dramas, and it expanded the League of Touring Theaters. Each of these initiatives is assessed in turn. The chapter then considers greater restrictions imposed on kabuki and other forms of theater and how kabuki's dramatic fictions had to compete with stories of real Japanese dying every day while fighting for the nation.