jimnoneill/paper-to-field-training huggingface dataset:
XMT-1660: A phase 1b trial of a B7-H4 targeted antibody drug conjugate (ADC) in breast, endometrial, and ovarian cancers.

Field: Medicine (Health Sciences)

TPS3154 Background: Breast cancer (BC) is the most commonly diagnosed cancer and one of the leading causes of cancer death in women. Despite significant therapeutic advances, the majority of patients with unresectable or recurrent/metastatic disease eventually develop resistance to available standard of care (SOC) therapies. High B7-H4 expression has been observed in several cancers including breast, endometrial, and ovarian, with limited expression in normal tissue. As a member of the CD28/B7 family of cell surface proteins, it promotes tumorigenesis by suppressing anti-tumor immunity. XMT-1660 is a B7-H4-directed Dolasynthen antibody drug conjugate designed with a precise, optimized drug-to-antibody ratio and a DolaLock microtubule inhibitor payload with controlled bystander effect. In the preclinical setting, XMT-1660 has demonstrated anti-tumor activity in TNBC and ER+/HER2- patient-derived xenograft mouse models, which included tumors from heavily pre-treated patients (Collins et al, AACR 2022). Increased anti-tumor activity tended to be more frequent in preclinical models with higher B7-H4 expression, providing rationale for a Ph1 clinical trial. Methods: The Ph1 trial includes a first-in-human open-label dose escalation (DES) portion followed by dose expansion (EXP) evaluating XMT-1660 in patients with BC, EC, and OC following progression on SOC as applicable (i.e., CDK4/6i + ET; platinum-based chemotherapy). In the DES, Bayesian Optimal Interval (BOIN) design will be used to determine the MTD. Patients will receive XMT-1660 IV Q3 weeks. Primary endpoints in DES are to assess safety and determine a recommended phase 2 dose (RP2D) and assessment of preliminary efficacy as a secondary endpoint. In parallel with DES, optional backfill cohorts will enroll patients into tumor-type specific cohorts (TNBC, HR+/HER2- BC, EC, or OC) at a selected dose level from DES and can be initiated at multiple dose levels simultaneously. In the EXP portion, cohorts enrolling TNBC, ER+/HER2- BC, EC/OC are planned and additional patients may be enrolled based on emerging data. The primary endpoint of EXP is to assess safety and tolerability, overall response rate, disease control rate, and duration of response. Secondary endpoints include pharmacokinetic analysis and assessment of antidrug antibodies. Patients are not selected by B7-H4 status, but baseline tumors samples are collected for retrospective tumor tissue evaluation. The trial is currently enrolling patients. NCT05377996. Clinical trial information: NCT05377996 .
HARMONICS – TO – NOISE RATIO IN IKA IGBO AND ENGLISH UTTERANCES: IMPLICATIONS AND INFERENCES

Field: Arts and Humanities (Social Sciences)

Sixteen utterances comprising eight Ika Igbo utterances and eight English utterances were produced and fed into the computer. The cross – correlation method of analysis was used to obtain their harmonics – to – noise ratios. Literature on Ika Igbo does not provide about harmonics – to – noise ratio. This study gives this information and compares the harmonics – to – noise ratio (degree of acoustic periodicity) of Ika Igbo and English. The comparison is necessitated by the existence of similar intonation patterns in both languages. The analysis revealed that generally, English utterances have higher harmonicity values than those of Ika Igbo, with the difference being more marked in some intonation patterns than others. Furthermore, the only Ika Igbo utterance with higher harmonicity value had more nasal sounds than its English counterpart. It is evidently clear from this research that English generally has higher degree of periodicity than Ika Igbo and that nasality increases periodicity. In addition, it is confirmed that periodicity is determined by type of intonation pattern and that lexical tone (which exists in Ika Igbo) reduces the degree of periodicity.
John Armstrong, MD, and the brain fever following intoxication

Field: Medicine (Health Sciences)

John Armstrong, MD, and the brain fever following intoxication Get access KEITH J. B. RIX, BMedBiol, MB, ChB, AIBiol, AIHE KEITH J. B. RIX, BMedBiol, MB, ChB, AIBiol, AIHE Aberdeen Royal InfirmaryForesterhill, Aberdeen, Scotland Search for other works by this author on: Oxford Academic PubMed Google Scholar Alcohol and Alcoholism, Volume 13, Issue 3, 1978, Pages 111–115, https://doi.org/10.1093/oxfordjournals.alcalc.a044115 Published: 01 August 1978
Elements of an effective portal

Field: Computer Science (Physical Sciences)

This thesis proposes an approach for rule-based personalization system. Through analyzing the based characters of rule-based personalization systems, this project decomposes the rules and provides a kind of atomic components named rule item. Users can use rule items to make up of rules for their own personalized profile. On the other hand, the system also traces the "mouse trails" to silently follow the visitors of the web site and finds the relationships between the actions of visitors. Based on these relationships, the system will automatically generate the rules for each visitor using the rule items according to his habit.
Article 108 [Change in circumstances]

Field: Arts and Humanities (Social Sciences)

Der Kommentar behandelt eingehend das maßgebliche Verfahrensrecht der drei Gerichte des Gerichtshofs der Europäischen Union: die Satzung des Gerichtshofs, die Verfahrensordnung des Gerichtshofs sowie die Verfahrensordnung des Gerichts einschließlich der hiervon abweichenden Regelungen betreffend das Gericht für den öffentlichen Dienst.
The Application of the ThroLy Risk Assessment Model to Predict Venous Thromboembolism in Patients with Diffuse Large B-Cell Lymphoma

Field: Medicine (Health Sciences)

Background Patients with aggressive lymphomas are at higher risk for venous thromboembolism (VTE). ThroLy is a risk assessment model (RAM) derived to predict the occurrence of VTE in various types of lymphomas. In this study, we assess the clinical application of ThroLy RAM in a unified group of patients with diffuse large B-cell lymphoma (DLBCL). Methods Hospital databases were searched for patients with DLBCL and radiologically-confirmed VTE. Items in the ThroLy RAM, including prior VTE, reduced mobility, obesity, extranodal disease, mediastinal involvement, neutropenia and hemoglobin < 10.0 g/dL, were retrospectively reviewed. Results A total of 524 patients, median age 49 (range: 18-90) years were included. Patients had high disease burden; 57.3% with stage III/IV and 34.0% with bulky disease. All were treated on unified guidelines; 63 (12.0%) had primary refractory disease. Venous thromboembolic events were reported in 71 (13.5%) patients. Among 121 patients with high (> 3) ThroLy score, 22.3% developed VTE compared to 8.4% and 12.4% in those with low and intermediate risk scores, respectively ( P = .014). Simplifying the ThroLy model into two risk groups; high-risk (score ≥ 3) and low risk (score < 3) can still segregate patients; VTE developed in 44 (17.2%) high-risk patients ( n = 256) compared to 27 (10.1%) in the low-risk group ( n = 268), P = .038. Neutropenia, a component of the ThroLy, was encountered in only 14 (2.7%) patients. Conclusions ThroLy RAM can identify patients with DLBCL at high risk for VTE. Model can be modified by dividing patients into two, rather than three risk groups, and further simplified by omitting neutropenia.
In vitro and in vivo biofilm adhesion to esthetic coated arch wires and its correlation with surface roughness

Field: Dentistry (Health Sciences)

ABSTRACT Objective: To evaluate the in vitro ability of esthetic coated rectangular arch wires to retain oral biofilms and in vivo biofilm formation on these wires after 4 and 8 weeks of clinical use and to correlate the findings with the surface roughness of these wires. Materials and Methods: Three brands of esthetic coated nickel-titanium (NiTi) arch wires were selected. Arch wires retrieved after 4 and 8 weeks of intraoral use were obtained from 30 orthodontic patients. Surface roughness (SR) was assessed with an atomic force microscope. In vitro adhesion assays were performed using Streptococcus mutans (MS), Staphylococcus aureus, and Candida albicans. The amount of bacterial adhesion was quantified using the colony-count method. Paired t-test, analysis of variance, post hoc Tukey's test, and Pearson's correlation coefficient test were used for statistical analysis at the .05 level of significance. Results: In vitro bacterial adhesion showed significant differences between wires in terms of MS adhesion (P = .01). All wires showed significant increases in SR (P = .001 after 4 weeks and .007 after 8 weeks) and biofilm adhesion (P = .0001 after 4 weeks and .045 after 8 weeks) after intraoral exposure. A significant positive correlation (P = .001 after 4 weeks and .05 after 8 weeks) was observed between these two variables in vivo, but the correlation was not significant for in vitro bacterial adhesion. Conclusions: SR and biofilm adhesion increased after intraoral use at all time intervals. There was a positive correlation between SR and biofilm adhesion in vivo only.
Spatial characterization of raincell horizontal profiles from C-band radar measurements at mid-latitude

Field: Earth and Planetary Sciences (Physical Sciences)

Abstract. A spatial characterization of mid-latitude mesoscale rain fields from C-band radar measurements is performed by means of a systematic analysis and modelling of convective raincell shapes. To this aim a large rainfall dataset, derived from an operational C-band dual-polarized radar, has been continuously collected from 1996 to 1999. The radar-derived rain fields consist of 1558 grids of 256×256 km2 with a spatial resolution of 1 km. A new accurate and adaptive algorithm for raincell identification is introduced and thoroughly discussed. From this analysis, a quality-controlled set of 2601 raincells, together with the radial rain intensities (or raincell horizontal profiles), is extracted. Three one-dimensional analytical models of rainfall horizontal profile are reviewed and tested by best fitting their parameters against estimated raincell data. The statistical results of this intercomparison are quantitatively analyzed and discussed in terms of mean rainfall horizontal profiles and root mean square errors.
Amplitude demodulation-based EM analysis of different RSA implementations

Field: Computer Science (Physical Sciences)

This paper presents a fully numeric amplitude-demodulation based technique to enhance simple electromagnetic analyses. The technique, thanks to the removal of the clock harmonics and some noise sources, allows efficiently disclosing the leaking information. It has been applied to three different modular exponentiation algorithms, mapped onto the same multiplexed architecture. The latter is able to perform the exponentiation with successive modular multiplications using the Montgomery method. Experimental results demonstrate the efficiency of the applied demodulation based technique and also point out the remaining weaknesses of the considered architecture to retrieve secret keys.
The Forward Puzzle: The Roles of Exchange Rate Regime and Base Currency Strength

Field: Economics, Econometrics and Finance (Social Sciences)

ABSTRACT The forward puzzle is traditionally explained as the presence of a covariance‐risk premium, market friction or limits to arbitrage. Recently, Liu and Sercu, working on intra‐ERM rates for the DEM, presented evidence consistent with career risk considerations: portfolio managers shun assets with danger signals. In this paper, we test the external validity of this finding: we compare floating rates to band regimes, and strong base currencies to weak ones. We find that both the exchange rate regime and base currency strength influence the evidence on various theories: floating and strong intra‐ERM rates weakly support market friction or limit‐to‐arbitrage theories, while the HKD and weak intra‐ERM strongly support the career risk effect. We also decompose forward premium into a short‐term filtered component and a long memory trend. The filtered component is good at recognising danger signals or ‘extreme’ observation effects for band regime rates and weak floaters, while the trend works best for strong floaters. Lastly, the filtered premium provides the best fit, consistent with the idea that it has a closer link to expectations than the trend component.
Diffuse axonal injury by simple fall.

Field: Medicine (Health Sciences)

Diffuse axonal injury (DAI) is the second most common lethal head trauma after subdural hematoma and probably the most frequent cause of traumatic coma in the absence of an expanding intracranial mass lesion. Though it occurs most often in traffic accidents, it may occasionally result from falls from a height. Previously, it has not been associated with a simple fall or a fall of a distance not more than the victim's own height. We report herein a case of DAI from a simple fall.
Comparison of extracorporeal cellular therapy (ELAD®) vs standard of care in a randomized controlled clinical trial in treating Chinese subjects with acute-on-chronic liver failure

Field: Medicine (Health Sciences)

Zhongping Duan,1,* Shaojie Xin,2,* Jing Zhang,1 Shaoli You,2 Yu Chen,1 Hongling Liu,2 Sujun Zheng,1 Zheng Li,3 Robert Ashley,3 Michael Millis4 1Artificial Liver Center, Beijing You’an Hospital of Capital Medical University, Beijing, China; 2Department of Infectious Disease, Division III, 302 Military Hospital of China, Beijing, China; 3Research and Development, Vital Therapies, Inc, San Diego, CA, USA; 4Department of Surgery, University of Chicago, Chicago, IL, USA *These authors contributed equally to this work Background: Preliminary evidence of safety and efficacy of an extracorporeal cellular therapy (ELAD®) has been demonstrated in subjects with acute forms of liver failure. This study compared ELAD with standard of care in Chinese subjects with acute-on-chronic liver failure (ACLF), predominantly secondary to chronic viral hepatitis.Subjects and methods: Subjects meeting eligibility criteria were randomized to either the ELAD group or the control group. All subjects received plasma exchange and venovenous hemofiltration and either ELAD treatment for 3–5 days, unless terminated early, along with standard of care or standard of care alone (control) and were then followed up for 12 weeks.Results: Forty-nine subjects (ELAD subjects, 32; controls, 17) were randomized under this protocol. Kaplan–Meier analysis of transplant-free survival (TFS) revealed a significant difference in favor of ELAD vs control (P=0.049, Wilcoxon signed-rank test). There was a significant difference in TFS on day 28 in ELAD vs control (P=0.022). In a multiple regression model, the relationship between group assignment and outcome was significant (P=0.031) when changes in food intake and Model for End-Stage Liver Disease (MELD) scores at screening were included as additional independent variables. The duration of ELAD treatment alone was a significant predictor of TFS (P=0.043). Median time to a 5-point increase in MELD, transplant, or death was longer than 72 days with ELAD vs 26 days for control (P=0.036). Total bilirubin level decreased by 25% during ELAD treatment vs 37% increase in the control group (P<0.001) over an equivalent period. Adverse events attributed to the ELAD system were expected and could be managed conservatively. Intergroup differences in certain vital signs and laboratory parameters were noted during treatment and generally resolved posttreatment.Conclusion: ELAD treatment was well tolerated by Chinese subjects with ACLF, predominately secondary to chronic viral hepatitis. Results demonstrate a significant improvement in TFS in ELAD vs control groups in association with significant improvements in serum bilirubin levels presumably related to improvement in hepatic function. Keywords: acute-on-chronic liver failure, ELAD, bioartificial liver support, ACLF, C3A cells, cellular therapy
Enhanced d‐p Orbital Hybridization for Lithium Polysulfide Capturing and Lithium Deposition Inducing of AgVO3 Skeleton Enabling High‐Performance Li‐Sulfur Batteries

Field: Materials Science (Physical Sciences)

Abstract The dendrite growth and volume expansion of the Li metal anode, as well as the LiPSs “shuttle effect” and slow conversion kinetics of the S cathode, have severely hampered the large‐scale development of LSBs. Herein, a simple hydrothermal method is employed to synthesize rod‐like AgVO 3 , which is then used as the Li metal anode current collector and the separator modification, respectively. As the Li metal anode current collector, AgVO 3 has a strong Li affinity, which can lower Li nucleation overpotential and guide uniform deposition of Li metal. The AgVO 3 ‐modified separator can accelerate the redox kinetics of LiPSs and achieve the anchoring of LiPSs. The results of DFT calculation and experiments reveal that the AgVO 3 enable the Ag horizontal d orbitals (d xy /d x 2 ‐y 2 ) to hybridize with the S p orbital to form additional σ/σ* and π/π*. The activation of horizontal d orbitals can increase LiPSs anchoring ability, reduce the reaction barrier, and accelerate LiPSs transformation. Hence, the LSBs assembled with the Li@AgVO 3 anode and AgVO 3 modified separator show excellent cycle performance. This work gives a novel idea for the application of high catalytic performance materials represented by AgVO 3 , and its unique catalytic performance can successfully achieve LSBs with high performance.
Post-partum pelvic floor dysfunction assessed on 3D rotational ultrasound: a prospective study on women with first- and second-degree perineal tears and episiotomy

Field: Medicine (Health Sciences)

Purpose: To evaluate the morphology and biometry of pelvic floor structures 3 months after birth in women experiencing first- or second-degree perineal tears or undergoing episiotomy during labor. Material and methods: Prospective observational study including nulliparous women delivering at term with a clinical diagnosis of first- or second-degree perineal tears after birth or undergoing episiotomy. The role of Kristeller maneuver during labor in affecting pelvic structure and function is also explored. All women underwent 2D trans-perineal and 3D endovaginal or endoanal ultrasound 3 months after birth. Results: 115 women assessed 3 months after delivery were enrolled in the study. Compared with controls, women who experienced first-degree perineal tears had higher bladder neck-symphysis (versus 20.9 ± 4.9 versus 16.1 ± 4.9 mm, p = .017), bladder wall-pubic symphysis (22.4 ± 7.4 versus 14.2 ± 9.5 mm, p = .02) and anorectal angle-symphysis distance (12.5 ± 4.7 versus 9.3 ± 4.3 mm, p = .018). Furthermore, they have thicker internal and external anal sphincter. The incidence of partial right and left pubo-rectalis muscle avulsion was higher in women experiencing first-degree vaginal tear during labor (16.2 versus 0%, p = .004 for both). In women affected by second-degree tears, the occurrence of partial avulsion of the right and left pubo-rectalis muscle was 16.2%, while Oasis was detected in 10.8% of the cases. Women receiving Kristeller maneuver during labor had a higher incidence of either right or left puborectalis muscle avulsion. Conclusion: Women who had either first- and second-degree perineal tears or episiotomy show signs of abnormal pelvic morphometry on 3D rotational ultrasound 3 months after birth.
Room Temperature Operation of Strain-Compensated 5.5μm Quantum Cascade Lasers

Field: Physics and Astronomy (Physical Sciences)

Room temperature operation is an important criterion for high performance of quantum cascade lasers. A strain-compensated quantum cascade laser（λ≈5.5μm） with optimized waveguide structure lasing at room temperature is reported. Accurate control of layer thickness and strain-compensated material composition is demonstrated using X-ray diffraction. An output power of at least 45mW per facet is realized for a 20μm-wide and 2mm-long laser at room temperature.
Translating Clinical Pharmacology Data in Pregnancy to Evidence‐Based Guideline Recommendations: Perspectives From the HIV Field

Field: Medicine (Health Sciences)

Abstract Pharmacokinetic (PK) studies in pregnant, postpartum, and breastfeeding people are critical to informing appropriate medication use and dosing. A key component of translating PK results in these complex populations into clinical practice involves the systematic review and interpretation of data by guideline panels, composed of clinicians, scientists, and community members, to leverage available data for informed decision making by clinicians and patients and offer clinical best practices. Interpretation of PK data in pregnancy involves evaluation of multiple factors such as the study design, target population, and type of sampling performed. Assessments of fetal and infant drug exposure while in utero or during breastfeeding, respectively, are also critical for informing whether medications are safe to use during pregnancy and throughout postpartum in lactating people. This review will provide an overview of this translational process, discussion of the various factors considered by guideline panels, and practical aspects of implementing certain recommendations, using the HIV field as an example.
Recent Advance in Fungal Polygalaturonase

Field: Agricultural and Biological Sciences (Life Sciences)

Polygalacturonase,which digests the pectin in plant cell wall,is one of the pathogenesis of plant pathogenic fungi.The present review featured the sequence character of the fungal polygalacturonases and their genes.Regulation of the gene expression,and the relationship of polygalacturonase and the pathogenesis of plant pathogenic fungi were also reviewed.
Intent-Based Networking Architecture: A Deep Dive into Its Components and Workflow

Field: Computer Science (Physical Sciences)

Intent-Based Networking (IBN) represents a revolutionary transformation in network management, leveraging artificial intelligence, machine learning, and software-defined networking principles to automate and optimize network operations. This architectural framework enables organizations to define network behavior through business objectives rather than technical configurations, fundamentally changing how networks are managed and secured. The integration of automated policy enforcement, dynamic security controls, and intelligent orchestration capabilities allows organizations to maintain optimal network performance while ensuring compliance with security requirements. IBN's implementation spans various sectors, including financial services, healthcare, and government applications, with significant adoption in North America and growing deployment across the Asia Pacific region. Through its sophisticated components and workflows, IBN provides organizations with automation, security, and operational efficiency benefits while adapting to evolving technological landscapes and business needs.