jimnoneill/paper-to-field-training huggingface dataset:
Study on Anti-Inflammatory Mechanism of Angelica pubescens Based on Network Pharmacology and Molecular Docking

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

References and data show that AP has a certain effect on alleviating inflammation. Based on the methods of network pharmacology and molecular docking, this paper predicts the potential mechanism of anti-inflammatory effect of the effective components. Methods: Active components and target genes of AP were screened out by SymMap, an associated database of TCM syndromes. First, screen out the active components according to the setting conditions, and its molecular structure file was obtained from the PubChem database. The target genes of anti-inflammatory effect were obtained from GeneCards database with “anti-inflammation effect” as the keyword, and then the common gene targets between AP and anti-inflammatory effect were screened. The PPI network diagram was constructed with Cytoscape 3.80 software to screen the core genes. The GO function and KEGG pathway of the core genes were enriched and analyzed by David database; 3D view of proteins encoded by the core gene from the PDB database, conduct molecular docking between the active components and the core proteins in Auto Dock Vina software, and made a heat map with binding free energy. Results: The main anti-inflammatory components were O-Acetylcolumbianetin, isoindigo, Nodakenetin, Marmesin, Diphencyprone; The core targets are TNF, VEGFA, IL6, TP53, IL1B, ESR1, MMP9, PPARG, Jun, CASP3, PTGS2. AP participated in cytokine-mediated signaling pathway, response to drug, positive regulation of gene expression, and other processes by regulating the combination of extracellular space, cell surface with protein and enzyme, and then exert anti-inflammatory activity. The signal pathways mainly involved IL-17 signaling pathway, hepatitis B, TNF signaling pathway, inflammatory bowel disease, rheumatoid arthritis, etc.; Through molecular docking, it was found that the key targets were MMP9, TNF, PTGS2, ESR1, JUN, and PPARG, while the active components which ha,d a strong effect on these genes were O-Acetylcolumbianetin, isoindigo, Nodakenetin, Marmesin, Diphencyprone. Conclusion: This study used network pharmacology and molecular docking methods to predict the potential active components, target genes, and signal pathways of the anti-inflammatory effect of AP, so as to provide a theoretical reference for the follow-up experimental research and clinical treatment of AP.
Gains and Losses in a Trade Bloc: The Case of the East African Community

Field: Economics, Econometrics and Finance (Social Sciences)

From birth to death in the 1970s, to rebirth in the 2000s, the East African Community (EAC) had several lives. What were the economic consequences of this regional trade agreement? This paper shows that the former EAC was ine?cient in term of trade creation while on the contrary the current one has increased trade by 75%. These results are obtained with a structural gravity equation with importer-year, exporter-year e?ects and bilateral ?xed e?ects. To assess the global e?ect of the EAC, including trade diversion and general equilibrium e?ects, we then use a multi-sector and multi-country model. We ?nd that despite trade creation, the total welfare gains of the EAC is small for most countries. All members endured a depreciation of the terms of trade, trade diversion and a decrease in real wages at the exception of Kenya.
A Survey of the Canals and Water Raceways of New Jersey

Field: Earth and Planetary Sciences (Physical Sciences)

Canals and water raceways played an important role in the history and economic development of New Jer-sey. Much of the early settlement and industrial activity centered on areas with water transportation and water power. But many of these canals and raceways have been forgotten and lost. A small percentage still exist as abandoned waterways. A smaller percentage are still in use, for either their original purpose or for recreation. A new survey of the current and historic canals and water raceways of New Jersey found 171 of them. The locations are available in a GIS shapefile that indicates their current status (active or abandoned) and condition (wet or dry). The shapefile also shows the locations of locks and inclined planes on the Mor-ris Canal and the Delaware & Raritan Canal. The number of mapped historical water raceways in an area directly correlated to the interest and activity of local historians. Undoubtedly many more water raceways remain to be rediscovered. This report will be updated by the New Jersey Geological Survey as additional canals and water raceways are identified and reliably located.
Giant Bowen’s disease of anterior abdominal wall with invasive squamous cell carcinoma-A rare case report

Field: Medicine (Health Sciences)

A 65 years old male presented to the out-patient department of Dermatology with complaints of a large verruco-erosive lesion on left anterior abdominal wall for 15 years. A wedge incision biopsy was done which showed features of Bowen’s disease. The patient was referred to department of General Surgery where a complete excision was done. The final histopathology report confirmed the diagnosis of Bowen disease with a focus of invasive carcinoma component. This case report is unusual for its clinical presentation, duration and location of the lesion.
Contact Dermatitis from Imitation Jewelry: Clinical Insights from A Case Report

Field: Medicine (Health Sciences)

Irritant contact dermatitis (ICD) is a frequent inflammatory skin condition caused by exposure to allergens. Imitation jewelry, often made from inexpensive metals such as nickel, cobalt, or chromium, is a known source of sensitizing agents. We report the case of a 50-year-old female who developed symptoms over the neck region following the use of imitation necklace. Patch testing confirmed sensitivity to nickel. The dermatitis resolved with the avoidance of allergen exposure and appropriate therapy with corticosteroids and antihistamines. This case highlights the importance of recognizing everyday items such as costume jewelry as potential allergens, and emphasizes the role of patient education in the prevention of recurrent episodes.
Learning Cycle Length Through Finite Automata

Field: Computer Science (Physical Sciences)

We study the space-and-time automaton-complexity of two related problems concerning the cycle length of a periodic stream of input bits. One problem is to find the exact cycle length of a periodic stream of input bits provided that the cycle length is bounded by a known parameter n. The other problem is to find a large number k that divides the cycle length. By “large” we mean that there is an unbounded increasing function f(n), such that either k is greater than f(n) or k is the exact cycle length. Our main results include that finding a large divisor of the cycle length can be solved in deterministic linear TIME and sub-linear SPACE, whereas finding the exact cycle length cannot be solved in deterministic TIME × SPACE smaller than a constant times n squared. Results involving probabilistic automata and applications to rate-distortion theory and repeated games are also discussed.
Improvisation for the Theater: A Handbook of Teaching and Directing Techniques

Field: Arts and Humanities (Social Sciences)

This work has inspired the work of countless actors, directors, and writers in theatre, television and film. Spolin's improvisational techniques have changed the very nature and practice of modern theatre. This third edition updates the more than 200 now-classic exercises and adds 30 new ones. It adds 30 traditional theatre games that are frequently used as warm-ups. It includes Spolin's explanations of key concepts crucial to her programme, and collects The Sayings of Viola and adds a glossary of phrases for teachers and directors, with Spolin's definitions of their meaning and value. Most significantly, though, this edition makes available The Lone Actor. In this section, Spolin offers games for individuals to play when they are alone. It is an important piece that should expand Spolin's teachings and influence to an entirely new audience.
Arteriovenography of the Portal System

Field: Medicine (Health Sciences)

orf strains failed to grow on passage although cytopathic change was produced initially, and a third strain failed to produce any detectable changes in tissue culture.It should be noted that the minimum times given in Table II for a cultural diagnosis are only the earliest appearance of sufficient cytopathic change to be considered typical enough TABLE II.-Minimum Times Before a Provisional Diagnosis was Possible Tissue Culture Electron Earliest Characteristic C.P
Uncommon synchronous histopathological features of a radicular cyst: a case report

Field: Dentistry (Health Sciences)

Radicular cysts are the most common inflammatory odontogenic cystic lesions. It originates from epithelial residues in periodontal ligaments secondary to inflammation. The pathogenesis involves the activation of epithelial cell rests of Malaseez after physical, chemical or bacterial injury. Microscopically, the cyst is thin with smooth or corrugated inner surface. The most common epithelial lining is stratified squamous; with Rushton's hyaline bodies in 10% of the reported cases. Slow accumulation and deposition of cholesterol during the inflammatory process leads to the formation of "clefts" with acute and chronic inflammatory cells in the proliferating epithelium and connective tissue, respectively. The presence of hemosiderin usually indicates a previous micro-hemorrhage event. While the presence of lipid-laden macrophages or foam cells indicate the presence of cholesterol-removing mechanism from the lesion. We report a rare case of 38-year-old Mediterranean female presented with throbbing right maxillary pain. The diagnosis of radicular cyst was confirmed by the presence of atrophic non-keratinized stratified squamous epithelium. The radicular cyst was associated with hemosiderin, foam cells, subepithelial fibrosis and root canal dystrophic calcification. They represent uncommon synchronous histopathological features.
The Use of Breathing Rhythm to Enhance the Vividness of Mental Imagery

Field: Psychology (Social Sciences)

The study assessed Jencks' claim that responses to certain suggestions are enhanced by being paced with different phases of the breathing cycle. Following hypnotic induction, twenty-four subjects were given four treatments in counterbalanced order: 1) exhalation-enhanced suggestions paced to exhalation, 2) inhalation-enhanced suggestions paced to inhalation, 3) inhalation-enhanced suggestions counterpaced to exhalation, and 4) exhalation-enhanced suggestions counterpaced to inhalation. Subjects' reports of imagery vividness provided marginal support ( p < .06) for Jencks' hypothesis. Post-experimental inquiry indicated subjects were unaware of the breathing contingency. Results suggest that appropriate pacing may make a greater difference for the energy-confidence group of suggestions (inhalation-paced) than for the calm-relaxation group (exhalation-paced).
Future Applications of Deoxycholic Acid in Body Contouring.

Field: Medicine (Health Sciences)

Deoxycholic acid (KybellaTM, Allergan Pharmaceuticals, Irvine, CA) is a novel injectable treatment used for the cosmetic reduction of redundant submental fat. By inducing adipose cell lysis, the soft tissue alteration induces subsequent contour change and sharpening of the cervicomental angle.The safety and efficacy have been well established in several prospective clinical trials and subsequent FDA approval for this purpose. This has provided an effective and less invasive alternative to surgical liposuction with virtually no recovery time and less overall discomfort. Given its success for use in this context, a logical step would be to extrapolate to other regions of the body where cosmetic deformity is caused by excessive adipose tissue. In the current article, the authors propose potential options for further use in various targeted areas where subcutaneous fat may be amenable to reduction with deoxycholic acid injection, understanding that such uses would be off-label and require an understanding of the regional anatomy and possible complications. J Drugs Dermatol. 2017;16(1):43-46.
How Advertising Beauty Influences Children’s Self-Perception and Behavior

Field: Psychology (Social Sciences)

The authors investigate (1) whether the physical attractiveness stereotype applies to children, (2) whether children’s self-perception is influenced by the attractiveness of an advertising model, (3) whether children’s buying intentions are influenced by the attractiveness of an advertising model, and (4) whether age, gender, and materialism affect (1), (2), and (3). Results of an experimental research (N=185) confirm the presence of the “what is beautiful is good” stereotype in children. Attractive (versus less attractive) models were also perceived to be less likely to follow the rules. Contrary to expectations from research in adult samples, the presence of an attractive (versus less attractive) model has a positive influence on perceived physical appearance for both boys and girls and also a positive influence on general self-worth for girls. The authors also found that attractive (versus less attractive) models increase attitudes and buying intentions for boys, but not for girls. No effects of age and materialism were found.
A programmable tunable active grounded and floating immittance circuit using CCTA and their applications

Field: Engineering (Physical Sciences)

This article presents a novel grounded and floating immittance circuit. It can simulate any one of the floating and grounded positive and negative inductor circuit, positive and negative capacitor circuit, and positive and negative resistor circuit. The novelty of the proposed circuit is its capability to provide positive and negative immittances without any change of passive component and matching condition. In addition, active realisations of positive and negative fractional order immittance circuits are presented. Thus, this paper presents 16 types of immittances which cover entire two-dimensional phase plane. Grounded immittance circuit uses one active block Current Conveyor Transconductance Amplifier (CCTA), one grounded MOS resistor and one grounded passive component while floating immittance circuit employs two CCTAs and three components. The immittance of the proposed circuits can be tuned by changing the bias current of CCTA and bias voltage of MOS resistor. The frequency responses of the proposed circuits are verified using SPICE simulation based on the 0.18 µm TSMC CMOS technology parameter. The performance of the proposed positive immittance circuits is demonstrated by active filter design using SPICE in conjunction with MATLAB. The performance of the proposed negative immittance circuit is demonstrated through inductance cancellation.
Prevalence and Factors Associated With the Informal Market for Medicines in Benin: A Community‐Based Cross‐Sectional Study

Field: Health Professions (Health Sciences)

ABSTRACT Background and Aims Medicines are intended to improve the health of individuals with various medical conditions, but their poor‐quality poses significant risks, especially in low‐ and middle‐income countries like Benin, where informally sold medicines are widely consumed. This study assessed the prevalence and factors associated with their consumption in Benin. Methods Conducted in 2018 across 72 districts of Cotonou, it targeted 864 households. Data collected included the consumption of these medicines, along with sociodemographic and socioeconomic information, as well as medicine‐related practices such as purchasing habits, self‐medication, medical consultation, access to the informal market, awareness of risks, and reasons for consumption. Results The results revealed a pattern of multiple‐source medicine procurement, with 25.5% (95% CI: 22.5%–28.5%) of individuals reporting the use of informally sold medicines, despite 83.84% of households obtaining medicines from pharmacies and a health service utilization rate of 58.1%. Factors associated with informal medicine consumption included a lack of awareness of the risks (PR = 2.31; 95% CI: 1.57–3.40; p < 0.001), exposure to malaria or pains (PR = 2.02; 95% CI: 1.04–3.94; p = 0.04), self‐medication (PR = 95.02; 95% CI: 25.57–353.15; p < 0.001), frequent purchases (PR = 1.90; 95% CI: 1.16–3.10; p = 0.01), irregular medicine availability in pharmacies (PR = 3.42; 95% CI: 2.26–5.16; p < 0.001), and other sources purchases (PR = 15.21; 95% CI: 7.52–30.78; p < 0.001). Conclusion Informal medicine use remains prevalent in Benin and is significantly driven by lack of awareness, exposure to malaria or pains, self‐medication, frequent purchases, irregular medicine availability, and infrequent pharmacies use. Addressing this issue requires strategic interventions such as raising public awareness and improving availability and access to quality medicines through authorized facilities.
Biochemical Predictors of Early Onset Non-Alcoholic Fatty Liver Disease in Young Children with Obesity

Field: Medicine (Health Sciences)

Although MS and NAFLD were more prevalent in adolescents, young children also demonstrated MS and NAFLD as obesity-related complications. Elevated serum γGT and uric acid levels may serve as biochemical predictors in detecting NAFLD in young children with obesity before investigation with abdominal USG.
Pennsylvania Sentencing Data, 1977, 1980, 1983

Field: Social Sciences (Social Sciences)

This data collection contains information on sentencing decisions in Pennsylvania for three years: 1977, 1980, and 1983. The 1977 data are based on separate 12-percent random samples of sentences selected from each of Pennsylvania's 67 counties. The 1980 data were collected in 23 of Pennsylvania's 67 counties. The sampling strategy varied by county, and a description is included in the codebook. The 1983 data are based on sentencing guideline forms submitted to the Commission by sentencing judges. The data include sentences imposed for felony and misdemeanor offenses, excluding driving under the influence. All three files contain demographic information, including defendant's sex, race, age, prior record, offense charge, sentences imposed, weapon usage, victim information, and socioeconomic status.
Neuroadaptive Changes Associated with Smoking: Structural and Functional Neural Changes in Nicotine Dependence

Field: Neuroscience (Life Sciences)

Tobacco smoking is the most frequent form of substance abuse. We provide a review of the neuroadaptive changes evidenced in human smokers with regard to the current neurobiological models of addiction. Addiction is thought to result from an interplay between positive and negative reinforcement. Positive reinforcing effects of the drugs are mediated by striatal dopamine release, while negative reinforcement involves the relief of withdrawal symptoms and neurobiological stress systems. In addition, drug-related stimuli are attributed with excessive motivational value and are thought to exert a control on the behavior. This mechanism plays a central role in drug maintenance and relapse. Further neuroadaptive changes associated with chronic use of the drug consist of reduced responses to natural rewards and in the activation of an antireward system, related to neurobiological stress systems. Reduced inhibitory cognitive control is believed to support the development and the maintenance of addiction. The findings observed in human nicotine dependence are generally in line with these models. The current state of the research indicates specific neuroadaptive changes associated with nicotine addiction that need to be further elucidated with regard to their role in the treatment of nicotine dependence.
Targeting KRAS Mutant Protein Inhibitor for Potential Treatment in Cancer

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTTargeting KRAS Mutant Protein Inhibitor for Potential Treatment in CancerRobert B. Kargbo*Robert B. KargboUsona Institute, 277 Granada Drive, San Luis Obispo, California 93401-7337, United States*Email: [email protected]More by Robert B. Kargbohttps://orcid.org/0000-0002-5539-6343Cite this: ACS Med. Chem. Lett. 2021, 12, 11, 1633–1634Publication Date (Web):October 7, 2021Publication History Received12 September 2021Published online7 October 2021Published inissue 11 November 2021https://pubs.acs.org/doi/10.1021/acsmedchemlett.1c00496https://doi.org/10.1021/acsmedchemlett.1c00496editorialACS PublicationsCopyright © Published 2021 by American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2147Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (758 KB) Get e-AlertscloseSUBJECTS:Alkyls,Assays,Cancer,Genetics,Inhibitors Get e-Alerts
Design and Improvement of Flattop Windows with Semi-Infinite Optimization

Field: Computer Science (Physical Sciences)

Digital and analog window optimization problems are often characterized by a few number of variables with many constraints. In some cases the optimization problem becomes semi-infinite, i.e. a finite number of variables with an infinite set of constraints. This paper presents a method for flattop window design and enhancement using the Dual Nested Complex Approximation (DNCA) algorithm. Flattop windows can be used for accurate amplitude measurements in spectral analysis and can also be used to design FIR filters with very high stopband attenuation. This paper proposes using the DNCA scheme to solve the optimization problem, due to its low computational complexity and memory consumption. It can be run on any desktop computer. The framework of the DNCA scheme is presented together with two examples; one concerning the design of an enhanced version of the ISO 18431-2 flattop window and the other concerns the design of a flattop window which is comparable with the commercial P-401.