jimnoneill/paper-to-field-training huggingface dataset:
Clinical efficacy and mechanism of alteplase combined with butylphthalide sodium chloride on patients with acute cerebral infarction

Field: Medicine (Health Sciences)

Objective To analysis the clinical efficacy of alteplase combined with butylphthalide sodium chloride injection on patients with acute cerebral infarction and its effect on the expression of serum stress factors.Methods A total of 142 patients with acute cerebral infarction were randomly divided into treatment group and control group,with 71 cases each. Patients in two groups were all treated with butylphthalide sodium chloride injection100 m L each time,twice a day,with over 6 h interval,injection time was 50- 70 min. Alteplase was added in treatment group on the basis of control group,5 mg alteplase was dissolved in 10 m L0. 9% Na Cl for intravenous injection within 10 seconds. The remaining45 mg was dissolved 0. 9% Na Cl in 100 m L for intravenous injection within 60 min,the injections were proceeded once a day. The course was2 weeks of the two groups. The clinical efficacy and the changes of neurological function and expression of stress factor of the 2 groups were compared. Results The total effective rate in treatment group was 95. 8%,and 83. 1% in control group( P 0. 05). Cerebral infarction volume and US National institutes of health stroke scale( NHISS)significantly reduced at 1 and 2 weeks after treatment in both groups,Barthel index( BI) significantly increased( P 0. 05). The improvement in the treatment group was more obvious( P 0. 05). Interleukin- 6( IL- 6),IL- 8,IL- 10,C- reaction protein significantly decreased( P 0. 05) after 1 and 2 weeks treatment in both groups,treatment group obviously decreased( P 0. 05). Conclusion Alteplase combined with butylphthalide sodium chloride injection could reduce the expression of serum stress factor in patients with acute cerebral infarction,and could control the volume of cerebral infarction and improve the neural function.
Exploiting whole genome sequence data to fine map and characterize candidate genes within a quantitative trait loci region affecting androstenone on porcine chromosome 5

Field: Agricultural and Biological Sciences (Life Sciences)

Summary Male piglets are routinely castrated to eliminate boar taint. However, this treatment is undesirable, and alternative approaches, including genetic strategies to reduce boar taint, are demanded. Androstenone is one of the causative agents of boar taint, and a QTL region affecting this pheromone has previously been reported on SSC 5: 22.6–24.8 Mb in Duroc. The QTL region is one of the few reported for androstenone that does not simultaneously affect levels of other sex steroids. The main objective of this study was to fine map this QTL . Whole genome sequence data from 23 Norwegian Duroc boars were analyzed to detect new polymorphisms within the QTL region. A subset of 161 SNP s was genotyped in 834 Duroc sires and analyzed for association with androstenone in adipose tissue and testosterone, estrone sulphate and 17 β ‐estradiol in blood plasma. Our results revealed 100 SNP s significantly associated with androstenone levels in fat ( P < 0.001) with 94 of the SNP s being in strong linkage disequilibrium in the region 23.03–24.27 Mb. This haplotype block contains at least four positional candidate genes ( HSD 17B6 , SDR 9C7 , RDH 16 and STAT 6 ) involved in androstenone biosynthesis. No significant associations were found between any of the SNP s and levels of testosterone and estrogens, confirming previous findings. The amount of phenotypic variance explained by single SNP s within the haplotype block was as high as 5.4%. As the SNP s in this region significantly affect levels of androstenone without affecting levels of other sex steroids, they are especially interesting as genetic markers for selection against boar taint.
FAIRY TALE PEDAGOGY IN PRIMARY SCHOOL: EUROPEAN PRACTICES

Field: Arts and Humanities (Social Sciences)

The article substantiates the theoretical and methodological essence of fairy tale pedagogy in primary school. The pedagogical essence of the primary school educational environment is analyzed. Its main characteristics are determined. It is established that fairy tale pedagogy is aimed at developing children's creative thinking, emotional intelligence, and social skills. Fairy tales become an integral part of the educational process thanks to interactivity, theatrical elements, and an emphasis on critical thinking. The role of fairy tale pedagogy in the formation of the personality of primary school students and the features of European practices of fairy tale pedagogy in primary school are considered. The technology of creating a corner of children's modern literature in primary school is described. The issue of the role of fairy tale pedagogy in the formation of the personality of primary school students and the peculiarities of European practices of fairy tale pedagogy in primary school are considered. The technology of creating a corner of children's modern literature in primary school is described. The main commonly used methods of European fairy tale pedagogy in primary education have been identified. They are the following: personified fairy tales, modern versions (mixed fairy tales), digitization of fairy tales, comic drawings, reader theater, thematic festivals, and excursions, fairy tale days, the fairy tale (library) corner, creating your own fairy tales, letters to favorite characters, retellings on behalf of a favorite character, elements of STEM (Science, Technology, Engineering, and Mathematics) and CLIL (Content and Language Integrated Learning).
Resistência do solo à penetração e ao cisalhamento em diversos usos do solo em áreas de preservação permanente

Field: Environmental Science (Physical Sciences)

A resistência do solo à penetração e ao cisalhamento pode ser utilizada como indicadores de compactação do solo e até indicar a suscetibilidade de um solo à erosão. O objetivo deste trabalho foi quantificar e comparar o impacto proporcionado por diferentes usos do solo em um Cambissolo Háplico em áreas de preservação permanente, a partir da resistência do solo à penetração e ao cisalhamento. A área experimental foi instalada em uma área de preservação permanente, na sub-bacia rio Ribeira de Iguape - SP, com diferentes usos do solo: cultivo de banana - CBAN, pastagem degradada - PDEG, sistema silvipastoril - MPIS e mata nativa - MNAT. O ensaio de resistência do solo à penetração foi realizado com um penetrômetro digital de esforço manual, até a profundidade de 40 cm. A resistência do solo ao cisalhamento foi determinada pelo ensaio de palheta (Vane Test) na profundidade entre 0 e 5 cm. A pastagem degradada foi semelhante à mata nativa, com menor resistência do solo à penetração. O cultivo de banana e o sistema silvipastoril foram os usos do solo que apresentaram maior resistência do solo à penetração. O solo sob mata nativa apresentou menor resistência ao cisalhamento. O cultivo de banana, a pastagem degradada e o sistema silvipastoril foram os usos do solo que apresentaram maior resistência do solo ao cisalhamento, indicando que o uso destes solos em áreas de preservação permanente está promovendo a compactação dos mesmos.
Anti-Arminians

Field: Arts and Humanities (Social Sciences)

This book is a study of the Anglican Reformed tradition (often inaccurately described as Calvinist) after the Restoration and it sets out to revise our picture of the theological world of the later Stuart period. Arguing that the importance of the Reformed theological tradition has frequently been underestimated, the study points to a network of conforming Reformed theologians which included many of the most prominent churchmen of the age. Focussing particularly on what these churchmen contributed in three hotly disputed areas of doctrine (justification, the Trinity and the divine attributes), the study argues that the most significant debates in speculative theology which erupted within the English Church after 1662 were the result of Anglican Reformed resistance to the growing influence of continental Arminianism. It demonstrates the strength and flexibility of the Reformed response to the developing Arminian school, and shows that the Reformed tradition remained a viable theological option for Anglicans well into the eighteenth century. The study therefore provides a significant bridge linking the Reformed writers of the Elizabethan and early Stuart period to the Reformed Evangelicals of the 18th Century. It also shows that, throughout its formative period, Anglicanism was not a monolithic tradition, but rather a contested ground between the competing claims of those adhering to the Church of England's Reformed doctrinal heritage and the insights of those who, to varying degrees, were prepared to explore new theological avenues.
Spouse's Personality and Marital Quality

Field: Psychology (Social Sciences)

Objective: To explore the relationship of spouse's personality and their marital quality.Methods:The marital quality and personality of 234 couples were measured with Chinese Marital Quality Inventory and Eysenck Personality Questionnaire revised in China.The relationship between marital quality and personality of each couple was analyzed.Results: The marital quality of couples with lower N score(T40), lower P score(T40), and higher L score(T=30-50) was better than that of couples with higher N score(T60), higher P score(T60), and lower L score(T30), there was uncertain relationship between E score and marital quality.Conclusion:Similarities and complementarities of spouse's personality are not certainly relation to marital quality, and marital quality is good in the couples with emotional stabilization, good communication, and proper leasing.
Evaluation of the predicted secondary structure of bacteriorhodopsin. Prediction of the bovine rhodopsin secondary structure and its sequence similarity with bacteriorhodopsin.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The secondary structure of bacteriorhodopsin (bacR) is predicted using the Chou and Fasman method in conjunction with the hydropathic index of Kyte and Doolittle. The predicted bacR structure was compared with the structure determined by Henderson et al. (1990) using electron diffraction and was found to correlate extremely well. The secondary structure of bovine rhodopsin (bovR) was then predicted using the same techniques. The proposed transmembrane regions of bovR were then examined and found to have sequence similarity with those transmembrane regions of bacR.
Modification and Methacrylation of Some New Aliphatic Hyperbranched Polyester Polyols Based on 1,3,5-Tris(2-hydroxyethyl) Cyanuric Acid (THECA) as a Core

Field: Chemistry (Physical Sciences)

Different generations of new aliphatic hyperbranched polyesters (G1–G3), based on the polycondensation of 2,2-bis(hydroxymethyl) propionic acid (bis-MPA) as a monomer and 1,3,5-tris(2-hydroxyethyl) cyanuric acid (THECA) as a core, were modified by reacting their hydroxyl end-groups with phthalic anhydride (PG1–PG3) and trimellitic anhydride (TG1–TG3), respectively. The modified samples were identified using IR and 1H-NMR spectroscopy. The percent modification of the different generations in both systems calculated via 1H-NMR was found to be above 80%. Thermal properties of the modified hyperbranched polyesters were investigated. A series of modified hyperbranched polyesters end-capped with various amounts of methacrylate groups was synthesized by reacting the different generations of the modified polyesters in both systems with glycidyl methacrylate. In order to elucidate the structural units in the prepared methacrylated polyesters, and to calculate the degree of functionality, all samples of both systems were identified using IR and 1H-NMR. T g and hardness values were also determined.
Uprooting the Pumpkin: Neo‐Colonial Therapeutic Interventions with Formerly Abducted Young People in northern Uganda

Field: Social Sciences (Social Sciences)

The impact of colonisation affects a number of formerly colonised societies. This paper addresses how therapeutic interventions in northern Uganda align with a colonial framework. It explores connections between the English invasion of northern Uganda in the mid‐1800s and therapeutic approaches to young people affected by armed conflict. Two case examples of treatment for young people at major reception centres are provided: (i) World Vision and (ii) Gulu Support the Children Organisation. Both draw on Western mental health interventions as the approach of choice rather than prioritising traditional Acholi values. This conceptual paper explores new directions for Western helping professional in the Global South.
Interannual Variability in Apricot Quality: Role of Calcium and Postharvest Treatments During Cold Storage and Shelf Life

Field: Agricultural and Biological Sciences (Life Sciences)

Extending the postharvest life of apricots (Prunus armeniaca L.) while maintaining their quality is a significant challenge due to their perishability, climacteric ripening, and susceptibility to mechanical injury. This study evaluated the effects of preharvest calcium (Ca) application and postharvest treatments, including modified-atmosphere packaging (MAP) and 1-methylcyclopropene (1-MCP), on apricot quality during storage, carried out in two production years (2016 and 2017) under contrasting climatic conditions. Apricot fruits, cv. ‘Buda’, were treated with Ca before harvest and subjected to MAP or 1-MCP postharvest treatment. Quality parameters, including firmness, color, total soluble solids (TSS), titratable acidity (TA), carotenoids, phenols, respiration rate, and sensory attributes, were analyzed over 15 days of cold storage followed by 3 days of shelf life (15 + 3). The growing season significantly influenced all measured parameters. Fruits harvested in 2017 had double the initial firmness compared to those from 2016 (50.03 N vs. 24.3 N), with higher sweetness and acidity scores. Ca treatment effectively reduced firmness loss by 30% in 2016, particularly beneficial under that year’s wetter conditions, but showed limited impact in the drier 2017 season. MAP successfully delayed ripening and maintained higher acidity levels across both years compared to controls. While 1-MCP treatment preserved fruit firmness effectively, it reduced sweetness perception by 37–59% and limited aroma development, with effects most pronounced in 2017. Sensory evaluation revealed no negative impacts of the applied treatments on overall taste acceptance, with Ca-treated fruits scoring significantly higher for sweetness than controls. The combination of preharvest Ca and postharvest treatments showed potential for extending apricots’ shelf life, but their efficacy was highly dependent on yearly climatic variability. These findings demonstrate that treatment effectiveness varies substantially between years, with Ca applications providing greater benefits in wet years, while 1-MCP and MAP showed more a consistent performance across varying climatic conditions. Therefore, customized and specifically tailored pre- and postharvest protocols are greatly needed to maintain the fruit quality and achieve targeted storage outcomes.
Cosmological models, observational data and tension in Hubble constant

Field: Physics and Astronomy (Physical Sciences)

We analyze how predictions of cosmological models depend on a choice of described observational data, restrictions on flatness, and how this choice can alleviate the $H_0$ tension. These effects are demonstrated in the $w$CDM model in comparison with the standard $Λ$CDM model. We describe the Pantheon sample observations of Type Ia supernovae, 31 Hubble parameter data points $H(z)$ from cosmic chronometers, the extended sample with 57 $H(z)$ data points and observational manifestations of cosmic microwave background radiation (CMB). For the $w$CDM and $Λ$CDM models in the flat case and with spatial curvature we calculate $χ^2$ functions for all observed data in different combinations, estimate optimal values of model parameters and their expected intervals. For both considered models the results essentially depend on a choice of data sets. In particular, for the $w$CDM model with $H(z)$ data, supernovae and CMB the $1σ$ estimations may vary from $H_0=67.52^{+0.96}_{-0.95}$ km\,/(s$\cdot$Mpc) (for all $N_H=57$ Hubble parameter data points) up to $H_0=70.87^{+1.63}_{-1.62}$ km\,/(s$\cdot$Mpc) for the flat case ($k=0$) and $N_H=31$. These results might be a hint how to alleviate the problem of $H_0$ tension: different estimates of the Hubble constant may be connected with filters and a choice of observational data.
COT-15 LITERATURE REVIEW ON THE DECISION MAKING OF THE BRAIN TUMOR PATIENT

Field: Medicine (Health Sciences)

Abstract BACKGROUND Patients with primary brain tumors find it difficult to make decisions during the advanced disease stage and experience decreased consciousness. It is important for patients to receive supported decision-making early. Medical staff should know what to do and when to do it,but there are no clear guidelines. Therefore,we reviewed the literature for supported decision-making for primary brain tumor patients,particularly to provide information for understanding trends reported in previous research. METHOD On January 1,2019,we conducted a search using keywords,such as “brain tumor”and “decision-making,” via PubMed and “Igakuchuo-zashi” in Japan. We extracted literature about treatment decision support and end-of-life care for patients with primary brain tumors. Furthermore,we studied and chose the documents for information provision. RESULT Upon observing 7 studies,we found: 1) about 50% of the patients want more prognostic information; 2) patients with brain tumor tend to be anxious,but they want more information to develop a good understanding of the disease and to lower their anxiety; 3) about half of the brain tumor patients in end-of-life care are unable to make decisions sooner owing to impaired consciousness,and hence are unable to share treatment preferences with their doctors; 4) when medical professionals provide information,such as adding video tools about end-of-life care to oral explanations,it facilitates supported decision-making; and 5) when the caregiver intends to notify patients,the family feels conflicted. DISCUSSION The results suggested that if the timing of the end-of-life conversation is late,it becomes difficult for the patient to make decisions and the burden of decision-making falls on the family. It is necessary to examine effective supported decision-making tools for patients by assessing and comprehending information needs and anxiety levels of primary brain tumor patients.
ChemInform Abstract: (4S)‐2,4‐Dimethyl‐2,4‐dihydro‐3,6‐dioxo‐(1H)‐pyrazino[2,1‐b]quinazolyl Tosylate as an Electrophilic Glycine Template.

Field: Chemistry (Physical Sciences)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Caldimonas manganoxidans gen. nov., sp. nov., a poly(3-hydroxybutyrate)-degrading, manganese-oxidizing thermophile.

Field: Immunology and Microbiology (Life Sciences)

A poly(3-hydroxybutyrate) (PHB)-degrading, gram-negative, aerobic bacterium, strain HS(T), was isolated from a hot spring and chemotaxonomically and phylogenetically characterized. The oxidase-positive, weakly catalase-positive, non-pigmented cells (0.6 x 2.6 microm) exhibited a single polar flagellum and accumulated PHB granules. Strain HS(T) was capable of manganese oxidation. Highest growth rate was attained at 50 degrees C. The optimum pH for growth was 7-8. The major respiratory quinone was ubiquinone-8 and major cellular fatty acids were C16:0, C16:1 and C18:1. The G+C content of the DNA was 66.2 mol%. Comparative 16S rDNA analysis indicated that strain HS(T) is related to the Rubrivivax subgroup and the family Comamonadaceae. The nearest phylogenetic relatives were Ideonella dechloratans (92.1% similarity), Leptothrix discophora (93.6%), Roseateles depolymerans (92.4%) and Rubrivivax gelatinosus (92.2%). On the basis of its phylogenetic and phenotypic properties, it is proposed that this isolate be designated Caldimonas manganoxidans gen. nov., sp. nov.; the type strain is HS(T) (= JCM 10698T = IFO 16448T = ATCC BAA-369T).
Fatigue Crack Growth of Low-Fluence Neutron-Irradiated Stainless Steel DIN 1.4948

Field: Materials Science (Physical Sciences)

Compact-tension (CT) specimens of stainless steel DIN 1.4948, which is similar to AISI Type 304, have been irradiated up to a fluence level of 2.1024 n.m.−2 (E &gt; 0.1 MeV) at temperatures ranging from 330 to 823 K. Post-irradiation constant-load-amplitude crack propagation (fcp) tests were performed in air at temperatures from 298 to 823 K with frequencies ranging from 10−3 to 10 Hz and R-ratios (min. load/max. load) of 0.05 and 0.30. Irradiation hardening after the low temperature irradiations (573 K and below) caused a reduction of the fatigue crack growth rate. Irradiation at the higher temperatures did not affect the fcp at the high frequency of 10 Hz. At 823 K the combination of high R-ratio and low frequency (10−2 Hz) resulted in an increase of the post-irradiation crack growth rate with a factor 10. This irradiation effect is attributed to the observed intergranular crack propagation.
Mapping Surveillance Capitalism in South American Higher Education

Field: Social Sciences (Social Sciences)

We are currently witnessing a global increase in the provision of software platforms and services, offered at ‘no cost’ by large corporations, to higher education. The business model behind these services is largely based on the collection and analysis of massive quantities of user data and metadata, collected through educational packages, which include e-mail, video-conferencing, groupware, file sharing, and other integrated services. The penetration of these services in higher education worldwide is largely unknown. In this study we discuss a methodology and a software script developed to collected new data for all 448 public higher education institutions in all 13 countries in South America. The data show that for every ten higher education institutions in the region, eight have services and platforms offered by such businesses. We contend that the adoption of these services is largely due to disinvestment in public education, and threaten the operational autonomy of institutions in regards to research and teaching, while leading to concerns in regards to data control, privacy, and transparency for teachers, administrators and students.