jimnoneill/paper-to-field-training huggingface dataset:
Abstract P6-08-50: Clinical predictors of long-term survival in Her2-positive (HER2+) metastatic breast cancer (MBC)

Field: Medicine (Health Sciences)

Abstract Introduction: Clinical observation suggests that a subset of patients with HER2+ MBC survive for prolonged periods when treated with Her2-targeting regimens. We hypothesized that we could identify clinical and pathological factors associated with prolonged survival. Methods: An IRB approved, retrospective, single institution review of patients diagnosed with HER2+ MBC was performed. Patients treated with pertuzumab or ado-trastuzumab emtansine were not included because recent FDA approval did not permit long-term follow-up. Clinical and pathologic characteristics were abstracted from the medical record. Kaplan Meier curves were constructed to evaluate time to progression after first metastasis, and overall survival from time of first metastasis. Cox proportional hazards analysis was used to assess for factors associated with long-term survival. A p value of &lt;0.05 is statistically significant. Results: Review identified 181 patients with HER2+ MBC. Median age was 47 (range 35-80). More than half (N=107) had hormone receptor positive disease; 21% had received adjuvant trastuzumab; and 25% had stage IV disease at diagnosis. Median overall survival from the time of MBC diagnosis was 4.2 yrs (range 0.1-15.5). Since the diagnosis of MBC, 70 (38%) survived for 5 or more yrs and 15 (8%) survived more than 10 yrs. One third (N=59) of patients had brain metastases. These patients had a median survival of 1.5 yrs (range 0-12.5 yrs) with 14% (N=8) living for more than 5 yrs following diagnosis of brain metastasis. Factors associated with decreased survival are listed in Table 1. Factors Associated with Decreased Survival in Her2+ MBCFactorHazard Ratio (95% C.I.)P ValueAge (continuous)1.03 (1.01-1.04)0.0004Time to recurrence (continuous)0.99 (0.94-1.04)0.74Hormone receptor positive0.70 (0.49-0.99)0.042Brain metastasis1.09 (0.77-1.56)0.63Adjuvant anti-Her2 therapy0.98 (0.61-1.58)0.94Multiple (vs single) sites of disease at initial diagnosis of MBC1.66 (1.17-2.35)0.005 Conclusions: In the treatment era of trastuzumab and lapatinib, 8% of patients within this cohort with HER2+ MBC lived more than 10 yrs. Analysis of current standard clinical and pathologic characteristics are not predictive of survival duration. Identifying factors associated with prolonged survival may provide insights for individualizing treatment selection. Citation Format: Pooja Murthy, Kelley M Kidwell, Dafydd G Thomas, Jennifer J Griggs, Sofia D Merajver, Anne F Schott, Jeffrey B Smerage, Catherine H Van Poznak, Max Wicha, Daniel F Hayes, N Lynn Henry. Clinical predictors of long-term survival in Her2-positive (HER2+) metastatic breast cancer (MBC) [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P6-08-50.
OQTOPUS Cloud

Field: Computer Science (Physical Sciences)

What's Changed CI/CD 🚀 ci:add labeler by @orangekame3 in https://github.com/oqtopus-team/oqtopus-cloud/pull/12 Documentation 📚 docs: update README.md by @eltociear in https://github.com/oqtopus-team/oqtopus-cloud/pull/7 chore: update badge status by @orangekame3 in https://github.com/oqtopus-team/oqtopus-cloud/pull/9 docs: add doi badge by @orangekame3 in https://github.com/oqtopus-team/oqtopus-cloud/pull/10 docs: Add release procedure by @orangekame3 in https://github.com/oqtopus-team/oqtopus-cloud/pull/11 docs:update openapi.md by @orangekame3 in https://github.com/oqtopus-team/oqtopus-cloud/pull/13 docs: update release note config by @orangekame3 in https://github.com/oqtopus-team/oqtopus-cloud/pull/15 New Contributors @eltociear made their first contribution in https://github.com/oqtopus-team/oqtopus-cloud/pull/7 @katsujukou made their first contribution in https://github.com/oqtopus-team/oqtopus-cloud/pull/14 Full Changelog: https://github.com/oqtopus-team/oqtopus-cloud/compare/v0.1.0...v0.1.1
Relationship between Photosynthesis, Transpiration and Water Use Efficiency of Rakkyo (Allium bakeri Regel) and Air Temperature, Relative Humidity and Light Intensity

Field: Agricultural and Biological Sciences (Life Sciences)

Photosynthesis (Pn) and transpiration (Tr) of rakkyo, a plant which can be cultivated without irrigation in sandy soil, is measured under several kinds of meteorological conditions, i. e., air temperature, relative humidity (RH) and light intensity. Several leaves of rakkyo were inserted into a small plastic assimilation box in a growth cabinet. The air temperature and relative humidity of the assimilation box and the growth cabinet were controlled. Experimental conditions were as follows: (1) Light intensity was constantly adjusted to 22klx by artificial lamps. Air temperatures were increased from 15°C to 35°C in 5°C steps. (2) Light intensity was charged from zero to 45klx. Four combinations of two air temperatures and two relative humidities were controlled in an assimilation box. These four combinations of environmental conditions were 15°C 50% RH, 15°C 70% RH, 30°C 25% RH and 30°C 70% RH.Photosynthesis and water use efficiency were high under conditions of low air temperature and high relative humidity, while transpiration showed the opposite tendency. In the case of 15°C 70% RH, 40klx, photosynthesis was 26mg CO2/dm2•h, transpiration was 0.6g H2O/dm2•h, and water use efficiency (Pn/Tr) was 38mg CO2/gH2O. At 30°C 25% RH, Pn was 19mg, Tr 2g and Pn/Tr 8mg/g, respectively.
Absence of large portal collateral vessels is associated with spontaneous improvement of cirrhotic portal vein thrombosis

Field: Medicine (Health Sciences)

Abstract Aim Portal vein thrombosis (PVT) is a major complication in patients with liver cirrhosis (LC). In some cases, PVT decreases spontaneously, but the factors that predict this are still not fully understood. Methods This was a retrospective, multicenter study that included 77 consecutive patients with cirrhotic PVT. Forty‐eight patients did not undergo anticoagulation and 29 patients did between the time of the first diagnosis of PVT and the follow‐up radiological imaging undertaken 1–6 months later. A complete disappearance and 25% shrinkage of PVT was defined as complete remission (CR) and partial remission (PR), respectively. Portosystemic collateral vessels larger than 9 mm in diameter were defined as large collateral vessels. Results Complete remission + PR was found in 37.5% of the anticoagulation‐naïve patients. On univariate analysis, the absence of large collateral vessels, absence of PVT in the main trunk of the portal vein, a high platelet count, and a low FIB‐4 index were significant factors associated with CR + PR. On multivariate analysis, the absence of large collateral vessels was the unique factor associated with CR + PR of PVT (odds ratio 5.9; 95% confidence interval, 1.73–20.1). The CR + PR rate for anticoagulated patients was 44.8%. However, no predictors for a good treatment effect of anticoagulation for PVT were identified. Conclusions Spontaneous improvement of PVT in patients with LC can be expected when large collateral vessels are absent. For these patients, the option of observing them without anticoagulation can be considered in expectation of spontaneous reduction of PVT.
Detection of Quinolone Resistance Qnr Genes and its Association with Extended Spectrum Β-Lactamase and Carbapenemase Genes in Qnr Positive Enterobacteriaceae in a Tertiary Hospital in Bangladesh

Field: Medicine (Health Sciences)

Background: Multidrug resistance in Enterobacteriaceae including resistance to quinolone is dramatically increasing day by day. Widespread use of quinolones against Enterobacteriaceae has contributed to the rise of drug resistance. Resistance to quinolone is generally due to chromosomal mutations in genes coding for the target molecules of these agents, namely the DNA gyrase and topoisomerase IV enzymes. Recently, a multiresistance plasmid is discovered that encodes transferable resistance to quinolones; its prevalence is increasing gradually throughout the world. Plasmids have a crucial role in the dissemination of drug resistance genes like plasmid mediated quinolone resistant (PMQR) genes, extended-spectrum β-lactamase (ESBL) genes and carbapenemase genes. Objective: To detect the prevalence of quinolone resistance Qnr genes and its association with extended-spectrum β-lactamase and carbapenemase genes in Qnr positive Enterobacteriaceae. Methods: A prospective cross sectional study was conducted from January 2015 to December 2015 at Dhaka Medical College hospital, Bangladesh. A total of 270 Enterobacteriaceae were isolated from 340 samples collecting from inpatient and outpatient departments of DMCH irrespective of age, sex and antibiotic intake. Qnr determinant screening among ciprofloxacin resistant strains were conducted using PCR amplification. Searching of Extended-spectrum β-lactamase and carbapenemase genes in Qnr positive Enterobacteriaceae were conducted also by using PCR. Results: The Qnr genes were detected in 141 (62.67%) of the 225 quinolone resistant isolates by using PCR. Highest proportion of QnrS (n =84, 59.57%) were detected followed by QnrB (n =70, 49.64%) and QnrA (n =33, 23.40%). In the present study, 48 ESBL producers were identified among 141 Qnr positive strains. Highest proportion of CTX-M-15 (n= 38, 69.09%) were detected followed by TEM (n= 20, 36.36%) and OXA-1 (n= 16, 29.09%). In the present study, 22 carbapenemase producers were .....
On Bandit Organizations and Their (IL)Legitimacy: Concept Development and Illustration

Field: Social Sciences (Social Sciences)

Outlaw organizations are neglected in organization studies. This is understandable given the presumption of illegitimacy they attract. Our article challenges the presumption by positing the concept of ‘bandit organizations’, demonstrating how some can build impressive levels of legitimacy among their audience. The case of Christopher ‘Dudas’ Coke, a philanthropic Jamaican drug cartel leader, and his ‘Shower Posse’ gang, is used to investigate how contemporary bandit organizations foster legitimacy. By placing ‘shadow economy’ organizations like this in the spotlight, we seek to extend scholarship on organizational legitimacy, while avoiding any undue romanticization of criminal organizations.
The Impact of Color Blindness on Player Engagement and Emotional Experience: A Multimodal Study in a Game-Based Environment

Field: Computer Science (Physical Sciences)

Purpose: Color blindness can create challenges in recognizing visual cues, potentially affecting players&#039; performance, emotional involvement, and overall gaming experience. This study examines the impact of color blindness on player engagement and emotional experience in digital games. The research aims to analyze how color-blind individuals engage with and emotionally respond to games, offering insights for more inclusive and accessible game design. Methodology/Approach: An experiment-based study was conducted using a between-group design with 8 color-blind and 8 non-color-blind participants (ages 18-30). The sample was carefully selected to ensure participants had similar levels of digital gaming experience and familiarity with digital games, reducing potential biases related to skill or prior exposure. A custom-designed game, &quot;Color Quest,&quot; was developed to assess engagement and emotional response. Emotional responses were measured through Emotion AI analysis, video recordings, and self-reported feedback forms. Participants were also asked to rate their engagement and emotional experience on a 1-to-5 scale, with additional qualitative feedback collected for deeper insights. Findings: The results indicate that color-blind players generally reported lower engagement levels compared to non-color-blind players. Although quantitative data did not reveal a direct correlation between color blindness and visual experience, self-reported feedback suggests that color-related design choices negatively impact emotional involvement and player immersion. Furthermore, in the survey responses directed to participants, color-blind individuals rated their experiences lower compared to individuals with normal vision. Participants emphasized that certain visual elements created difficulties in gameplay, and alternative sensory cues, such as audio feedback, helped mitigate these challenges. Originality/Value: This study provides a rigorous experimental evaluation of color blindness in gaming, emphasizing the role of sensory adaptation in improving player engagement and emotional experience. The findings contribute to game accessibility research by offering concrete design recommendations for developers to create more inclusive and engaging gaming experiences for color-blind individuals.
An Evaluation on Iran International Public Health Summer School in Relation to its Efficacy Based on Participants’ Experience and Opinions

Field: Health Professions (Health Sciences)

Background: A serious challenge to educate health staff for public health is to appear encouraging enough to persuade them for learning issues on this field and implementing new educational methods and innovative ways. Iran International Public Health Summer School (IPHS) made an effort to provide medical sciences students with a fortune to get familiar with and involved in public health. This study intended to evaluate the efficacy of this event. Materials and Methods: This cross-sectional study was performed in March–April 2015 by the help of an electronic self-administered questionnaire filled out by 49 Iranian participants 6 months after IPHS2014. The questionnaire assessed the main goals in seven main domains: Interest, activities, and general knowledge in the field of public health, general skills, educational methods, educational and executive schedules, and general satisfaction. Results: Average scores of all domains were >3 (the mean), and all were statistically significant. The highest average score belonged to educational methods (3.92) and the lowest was calculated for the item regarding participants’ activities on public health (3.5). No significant difference was found between positive answers of individuals who were interested or active in public health prior to the event and those who had no background. Conclusions: We believe IPHS was a unique instance in Public Health Education in Iran. Considering the level of success of this program to reach its goals for both students’ with or without any previous background on public health, it is recommended as a general model to be simulated in other developing countries.
Research on Optimization of Pasteurized Milk Cold Chain Logistics Distribution Network

Field: Decision Sciences (Social Sciences)

With the popularity of pasteurized milk.the requirements for quality and quantity from customers are increasing. This article takes cold chain distribution network of the Guangzhou dairy company as research object and bases on the special needs of pasteurized milk on time and temperature.establishing a vehicle routing optimization model of cold chain logistics with time window in dynamic network model through improving traditional vehicle routing problem. Also, a hybrid genetic algorithm is designed to solve the model which uses the excellent local search ability of hill climbing algorithm to optimize the genetic algorithm. Finally, it analyzes data from the company sets reasonable parameters and obtains the optimization results through which, the author gives corresponding recommendations in order to improve the quality of dairy products and the cold chain delivery efficiency of this company.
Sport participation should not be observed as protective against smoking and drinking in adolescence; cross-sectional cluster-based analysis in Croatian southern regions

Field: Social Sciences (Social Sciences)

Purpose: Sport participation in adolescence is frequently observed as being protective against consumption of psychoactive substances (e.g. cigarettes and alcohol), but limited number of studies directly examined this problem while simultaneously observing consump-tion of cigarettes and alcohol. The aim of this study was to evidence the possible associations which may exist between different factors explaining participation in sports, and consumption of cigarettes and alcohol in adolescents from Croatia. Methods: The sample comprised 436 adolescents from coastal regions in Croatia (202 fe-males) aged 15–17 years who were tested by previously validated closed structured ques-tionnaire on sport factors (experience in sports [four point scale from “never participated” to “ > 5 years”], sport competitive achievement [four point scale ranging from “never competed” to “national/international competitive achievement”], number of sport training sessions per week [four point scale ranging from “didn’t participate” to “sometimes even twice a day”]), cigarette smoking (four point scale ranging from “never smoked” to “more than 10 cigarettes per day”), and alcohol consumption (measured by Alcohol Use Disorders Identification Test – AUDIT). Cluster analysis calculated on the basis of cigarette smoking and AUDIT results was used to form homogenous groups (substance misuse clusters – SMC). The Kruskall Wallis analysis of variance (KWA) was calculated to identify the differences between SMC in studied sport factors. Results: Four SMC were formed indicating: (i) high alcohol + high cigarettes (SMC1: n=42), (ii) high alcohol + low cigarettes (SMC2: n=115), (iii) low alcohol + low cigarettes (SMC3: n=226), and (iv) low alcohol + high cigarettes consumption (SMC4: n=53). When calculat-ed for total sample of participants, the KWA revealed significant differences among SMC, with significant post-hoc differences between SMC1 and SMC3 in all sport-factors (H test: 9.5-to-17.5, p 80% of all SMC1 members). Gender-specific KWA did not reveal significant differences among SMC in studied sport factors. Conclusion: Study results do not support the theory of protective effects of sport participation against substance misuse in adolescence. Even more, there are some indices that sport par-ticipation may be observed risk factor for consumption of cigarettes and alcohol in this age group. Social acceptance of smoking and drinking in sport-society in the region is probable reason for relatively high rates of substance misuse in adolescents who are actively involved in sports.
QUANTUM LEARNING AND TEACHING Menuju Arah Pembelajaran Bermakna

Field: Arts and Humanities (Social Sciences)

Quantum Learning and Teaching is a trend of meaningful learning that allows the creation of fun atmosphere. Suggestion and motivation is one of the tricks or the key attraction of the students in the process of teaching and learning interactions. Happiness situation gives the positive impact on students peacefulness, which is absolutely recommended to every educator, is to be able to design or to combine various educational approaches in order to create a suggestion and the desire to gain the knowledge
Threshold conditions in SIR STD models

Field: Mathematics (Physical Sciences)

We propose and analyze a heterogeneous, multigroup, susceptibleinfective-recovery (SIR) sexually transmitted disease (STD) model where the desirability and acceptability in partnership formation are functions \nof the infected individuals. Then we investigate the dependent reproductive number (R0) at the βij (the probability of disease transmission per contact between an infected partner in group j and a susceptible individual in group i.), then we study the stability and unstability of the model in different states.
Battery Charging Method

Field: Engineering (Physical Sciences)

A charging and equalizing method for a battery having a control computer in a charging system in communication with a plurality of module processors. Charging and equalization pauses periodically for voltage measurement by the module processors. The control computer determines when to equalize battery cells in the modules based on their open circuit voltages transmitted by the module processors. A selected group of cells in each module can be equalized. Equalization is carried out in the modules until all of the module processors indicate that equalization has been completed. Charging can then resume until charging is complete or cells reach a maximum voltage given by the control computer. In an alternative embodiment, a selected group of cells may be partially bypassed while charging to reduce the charge rate of the cell.
Cost-effective indicator—a tool for resource prioritization

Field: Decision Sciences (Social Sciences)

For a long time now different importance measures are put to use in reliability literature for ranking events of a fault tree (FT). Commonly used importance measures accounts only the probability of occurrence of faults in the system and ignore the effect or severity of failures which is an important factor in engineering decision making. Here a new approach is proposed by evaluating an indicator, called cost-effective indicator (CEI) that accounts both the component's performance and economic aspects. The CEI is useful in production systems where operational reliability and cost of break down are paramount. Basic componente/events in an FT are ranked as per the decreasing value of this indicator to indicate the favourable area for improvement. It is observed in the analysis that CEI can be a handy and effective tool for inspection, maintenance and failure detection and these activities can be carried out as per the rank of the components. Upgradation of system's performance can also be done by improving components with relatively large CEI values.
VAV1 Gene Polymorphisms in Patients with Rheumatoid Arthritis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Introduction: Rheumatoid arthritis (RA) is an important public health problem because this disease often causes disability. RA is a chronic, destructive autoimmune disease that leads to joint destruction and the development of extraarticular manifestations. VAV1 is an intracellular signal transduction protein that plays a significant role in signal transduction in T cells and affects T cell development, proliferation and activation. The VAV1 gene contains 27 exons and is located on chromosome 19. In this study, we examined the association between VAV1 rs2546133 and rs2617822 polymorphisms and RA. Methods: We examined 422 patients with RA and 338 healthy subjects as the control group. Results: Among RA patients, there was a statistically significant increase in the frequency of VAV1 rs2546133 polymorphism in T allele carriers (TT + CT versus CC, odds ratio: 1.69, 95% confidence interval 1.05–2.73, p = 0.035). There was no statistically significant difference in the distribution of the rs2617822 genotypes and alleles between RA patients and the control group. Additionally, patients who carried the VAV1 rs2546133 T and rs2617822 G allele presented an increased frequency of extraarticular manifestations: vasculitis, amyloidosis and Sjogren syndrome. Conclusions: The results suggest an association between VAV1 gene rs2617822 polymorphism and RA.
Online-Capable Cleaning Of Highly Artefactual Eeg Data Recorded During Real Driving

Field: Computer Science (Physical Sciences)

With an increased interest to develop brain-computer interface (BCI) applications that can be used in real-world contexts, comes an increased need to deal with the myriad sources of artefacts that interfere with the signal of interest. We present real-world data recorded in a moving car, contaminated with muscle artifacts, mechanical artifacts, and noise produced by the car’s electrical systems. We use artifact subspace reconstruction and independent component analysis to rigorously clean and filter the data. We demonstrate that using state-of-the-art methods, it is possible to identify cortical processes even in heavily contaminated data.