jimnoneill/paper-to-field-training huggingface dataset:
Technophobes Teaching with Technology

Field: Social Sciences (Social Sciences)

Technology has been used in classroom situations for years now. Traditionally, technology has been used by faculty that were early adopters or who liked the technology. These faculty members would handle the implementation of technology and bring it into the classroom by themselves, with only a small amount of outside support. This evolved into faculty members who were comfortable with technology (but not early adopters) using more and more technology in the classroom with increasing outside support from IT staff and other faculty. What is happening now is that faculty members who are not comfortable with technology, or who are even technophobes, are using technology in increasing ways in the classroom.
Communicating With Realism and Hope: Incurable Cancer Patients' Views on the Disclosure of Prognosis

Field: Medicine (Health Sciences)

Purpose To identify preferences for the process of prognostic discussion among patients with incurable metastatic cancer and variables associated with those preferences. Patients and Methods One hundred twenty-six (58%) of 218 patients invited onto the study participated. Eligible patients were the consecutive metastatic cancer patients of 30 oncologists, who were diagnosed within 6 weeks to 6 months before recruitment, over 18 years of age, and without known mental illness. Patients completed a postal survey measuring patient preferences for the manner of delivery of prognostic information, including how doctors might instill hope. Results Ninety-eight percent of patients wanted their doctor to be realistic, provide an opportunity to ask questions, and acknowledge them as an individual when discussing prognosis. Doctor behaviors rated the most hope giving included offering the most up to date treatment (90%), appearing to know all there is to know about the patient's cancer (87%), and saying that pain will be controlled (87%). The majority of patients indicated that the doctor appearing to be nervous or uncomfortable (91%), giving the prognosis to the family first (87%), or using euphemisms (82%) would not facilitate hope. Factor analysis revealed six general styles and three hope factors; the most strongly endorsed styles were realism and individualized care and the expert/positive/collaborative approach. A range of demographic, psychological, and disease factors were associated with preferred general and hope-giving styles, including anxiety, information-seeking behavior, expected survival, and age. Conclusion The majority of patients preferred a realistic and individualized approach from the cancer specialist and detailed information when discussing prognosis.
A Tribute to Erika M. Plisetskaya: New Insights on the Function and Evolution of Gastroenteropancreatic Hormones. Introduction to the Symposium1

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Since the discovery of the first hormone, secretin, from the gastrointestinal tract by Bayliss and Starling in 1902, our knowledge of chemical mediators produced by the gastroenteropancreatic (GEP) system has grown considerably. The emergence of each new experimental approach ushered in a wave of new information. The latest developments in molecular biological approaches have and will continue to provide many important insights into hormone biology. Today, we know that the GEP cell feature of amine precursor uptake and decarboxylation (APUD) is shared by many other cell types (Norris, 1997); in fact, hormones secreted by the GEP also are secreted by cells of the nervous system, leading to the notion of a “brain-gut” distribution of hormones that makes the distinction between the endocrine system and nervous system no longer tenable (Thorndyke and Falkmer, 1985). We also now know that many GEP/neural hormones exist in a variety of molecular forms, sometimes co-localized with other factors, that modulate a vast array of functions in target cells that may be either distant or near to the site of secretion (see Holmgren, 1989). It is indeed interesting that the GEP system, the system that gave us the term “hormone” (Starling, 1905), now forces us to re-examine what a hormone is.

This symposium was designed to advance such a re-examination by bringing together GEP researchers whose recent work has provided new information on several critical issues that face hormone biology; among this information includes insights into the following topics: 1) origins of hormones, 2) hormone biosynthesis—from gene to bioactive peptide, 3) hormone structure-function relationships, and 4) ligand-receptor interactions. The comparative approaches employed by the participants uniquely posture this symposium to provide an integrated, up-to-date view about the evolution of the GEP system in animals.

This symposium was held in honor of Dr. Erika M. Plisetskaya. …
Digital Approach Provides Predictability in Increasing the VDO in Erosive Wear: Clinical Technique and 9‐Year Follow‐Up

Field: Dentistry (Health Sciences)

ABSTRACT Objective This clinical case describes a digital workflow using face scans and CAD/CAM technology for a full‐mouth rehabilitation with increased vertical dimension of occlusion (VDO) with adhesive lithium disilicate restorations after 9 years. Clinical Considerations A healthy, 46‐year‐old man displaying severe tooth wear, underwent an extensive full‐mouth rehabilitation involving an increase of the VDO through laminate veneers and adhesive partial coverage lithium disilicate restorations. Anatomical landmarks of the face and reference planes were captured using a digital face scanning system. The anatomical position of the maxilla was registered with a transfer device. Digital data sets of the intraoral situation combined with a facial scan enabled precise virtual planning, guiding minimally invasive preparations. Long‐term provisional restorations, milled from high‐performance polycarbonate, were used to test the novel VDO before the final lithium disilicate restorations were fabricated. This approach provided a time‐ and cost‐efficient treatment solution. No failures were observed at the 9‐year follow‐up. Conclusions Utilizing face scans and design software enable a virtual visualization and comprehensive quality control for patients with dental wear, resulting in significant time savings and increased predictability for the dental technician, dentist and patient. Clinical Significance The described digital workflow optimizes the planning and implementation of a comprehensive adhesive full‐arch rehabilitation with an increase of the VDO. The clinical long‐term follow up result of CAD/CAM assisted minimally invasive lithium disilicate restorations after 9 years demonstrates to clinicians a reliable treatment concept for patients with dental wear.
A Modified Cockcroft-Walton Quasi-Z Source Inverter with High Voltage Gain for Photovoltaic Systems

Field: Engineering (Physical Sciences)

This paper proposes a modified cockcroft-walton quasi-Z-source inverter (MCW-qZSI). The proposed inverter is conceived by embedding a boost cell reorganized and derived from the Cockcroft-Walton voltage multiplier into a traditional quasi-Z-source. Compared with the existing quasi-Z-source topology, it has a stronger voltage boost capability under the same total number of turns. The proposed circuit possesses all the advantages of a quasi-Z-source, such as continuous input current and common ground between input and output ends, while achieving high voltage gain at a small duty cycle, which results in a larger modulation index and higher output quality. In addition, the steady-state principle of the proposed inverter is analyzed. Also, its boost capacity, device voltage, current stresses, and superiority in magnetic devices are studied in detail. Then compare that with two typical (quasi-) $\mathrm{Z}$ sources. Finally, a prototype of the proposed MCW-qZSI has been produced with an output power of 720 W. Theoretical analysis and experimentation results are both given to verify the feasibility of the proposed MCW-qZSI.
Consistent Production of Mice with Conditional Knockout Alleles by CRISPR/Cas9-Mediated Genome Editing Using Two Guides/Two Oligos Approach

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Gene targeting is extensively used to generate designer mouse mutants and to study gene function in vivo. Knockout mice that harbor a null allele in their germline provide appropriate genetic models of inherited diseases and often exhibit embryonic or early postnatal lethality. To study gene function in adult mice and in selected cell types, a refined strategy for conditional gene inactivation has been developed that relies on the DNA recombinase Cre and its recognition (loxP) sites. This process has traditionally relied on the complex process involving genome editing in embryonic stem (ES) cells despite its limitations, including incorrect targeting or cassette structure, and difficulties with germline transmission of the allele from chimeric mice. CRISPR-Cas9 gene editing technology has considerably facilitated the generation of mouse knockout alleles, relieving many of the cumbersome and time-consuming steps of traditional mouse ES cell technology. However, the generation of conditional knockout alleles remains an important challenge. An earlier study reported up to 16% efficiency in generating conditional knockout alleles in mice using 2 single guide RNAs (sgRNA) and 2 single-stranded oligonucleotides (ssODN), which has been questioned by another report combining data from multiple transgenic cores. With the advent of CRISPR/Cas9 as a mouse genome modification tool, we assessed the efficiency of using this method in creating conditional targeted alleles in three genes, phosphatase and actin regulator 1 (Phactr1), apolipoprotein A-I (ApoA1), and actin-related protein T2 (Actrt2). Even though overall success rate was low—about 2.5%—we show that it’s possible to reliably generate conditional knockout alleles using CRISPR/Cas9 on a consistent basis.
Fluoroquinolone Prophylaxis in Autologous Hematopoietic Stem Cell Transplant Recipients

Field: Medicine (Health Sciences)

Although fluoroquinolone prophylaxis is frequently utilized in autologous hematopoietic stem cell transplant (AHSCT), there is a concern of increased risk of resistant organisms and C. difficile infection. This study investigates the effect of prophylactic norfloxacin 400mg BID on the incidence of bacteremia, C. difficile infection, intensive care unit (ICU) admissions, antibiotic use, engraftment and 100 day mortality.
Antigen‐presenting cell function of epidermal cells activated by hapten application

Field: Immunology and Microbiology (Life Sciences)

Exposure to haptens initiates a series of immune and inflammatory reactions that cause migration of epidermal Langerhans cells (LC) to draining lymph nodes, antigen processing, and presentation to T cells. In the present study, the antigen-presenting cell (APC) function of epidermal cells (EC) following hapten application was determined using a cell transfer system. This function of EC in inducing contact sensitivity (CS) in the recipient mice appeared as early as 6 h after hapten painting, and reached its maximum at 24 h. The amount of hapten on EC did not correlate with the function, i.e. the amount retained on the cells was greatest immediately after hapten painting and decreased over time. Several experiments were performed to identify the cell type responsible for the APC function. Through immunomagnetic bead separation, the APC function was detected in Ia- EC, as well as in unfractionated EC from hapten-painted mice. A purified population of Ia+ cells (LC) induced CS with much less efficiency than unseparated cells. Depletion of LC by anti-Ia monoclonal antibody (mAb) and complement-mediated lysis did not impair the APC function, whereas it was reduced by the depletion of Thy-1+ cells by anti-Thy-1 mAb and complement-mediated lysis. Moreover, adherent cells that were harvested from a 48-h culture of EC obtained from hapten-painted skin, and were free of contaminating LC and gamma omega T cells, had a strong capacity to induce CS. These findings indicate that keratinocytes (KC) acquire APC function as well as LC, with hapten application. Phenotypically increased expression of intercellular adhesion molecule-1 (ICAM-1) and Thy-1 on EC was observed following hapten application, whereas expression of Ia and B7/BB1 was unaltered. The APC function of EC from hapten-painted skin was dependent on ICAM-1 and Thy-1 expression, as the mAbs for these molecules reduced the capacity to induce CS. These results suggest that hapten application induces not only LC but also KC to mature functionally and become potent APCs, and that these KC exert the APC function complementarily at local sites following the migration of LC with potent APC function to the draining lymph node.
DIFFERENTIAL EXPRESSION OF GENES INVOLVED IN METABOLISM BETWEEN TUMORIGENITIC HUMAN LEUKEMIA CELL LINES K562 AND K562－n

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Objective: To study the molecular mechanism of different tumorigenicity in nude mice of human leukemia cell lines K562-n and K562. Methods: To analyze the genes differently expressed between K562 and K562-n cells by using cDNA microarray technique. Results: Among the 12800 genes detected, some genes involved in material metabolism and material transport were differently expressed between K562-n and K562 cells. These genes include homo sapiens placenta-specific ATP-binding cassette transporter gene, dihydrodiol dehydrogenase gene, hepatic dihydrodiol dehydrogenase gene, NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase, lysophosphatidic acid acyltransferase, alpha gene, argininosuccinate lyase gene, mitochondrial isocitrtate dehydrogenase, adhesion protein SQM1 gene, dimethylarginine dimethylamino-hydrolase gene, M1 subunit of ribonucleotide reductase and farnesyl pyrophosphate synthetase gene. Conclusion: The high tumorigenicity of K562-n cells is related to the different expression of some genes concerned with cell metabolism and material transpoert.
Industry views of the role of the Federal Government in industrial innovation

Field: Business, Management and Accounting (Social Sciences)

Industry views of the role of the Federal Government in industrial innovation Get access by Knight E K Kozmetsky G and Baca H R, The Graduate School of Business, The University of Texas at Austin, USA, 1976. Gordon Fryers Gordon Fryers director, Strategic Planning, Reckitt and Coleman, UK Search for other works by this author on: Oxford Academic Google Scholar Science and Public Policy, Volume 4, Issue 6, December 1977, Pages 572–573, https://doi.org/10.1093/spp/4.6.572 Published: 01 December 1977
Identification of SNPs Associated with Somatic Cell Score in Candidate Genes in Italian Holstein Friesian Bulls

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Mastitis is an infectious disease affecting the mammary gland, leading to inflammatory reactions and to heavy economic losses due to milk production decrease. One possible way to tackle the antimicrobial resistance issue stemming from antimicrobial therapy is to select animals with a genetic resistance to this disease. Therefore, aim of this study was to analyze the genetic variability of the SNPs found in candidate genes related to mastitis resistance in Holstein Friesian bulls. Target regions were amplified, sequenced by Next-Generation Sequencing technology on the Illumina® MiSeq, and then analyzed to find correlation with mastitis related phenotypes in 95 Italian Holstein bulls chosen with the aid of a selective genotyping approach. On a total of 557 detected mutations, 61 showed different genotype distribution in the tails of the deregressed EBVs for SCS and 15 were identified as significantly associated with the phenotype using two different approaches. The significant SNPs were identified in intergenic or intronic regions of six genes, known to be key components in the immune system (namely CXCR1, DCK, NOD2, MBL2, MBL1 and M-SAA3.2). These SNPs could be considered as candidates for a future genetic selection for mastitis resistance, although further studies are required to assess their presence in other dairy cattle breeds and their possible negative correlation with other traits.
K-0617 Thermoviscoelastic Analysis of Room-Temperature Shapes of CFRP Laminate

Field: Engineering (Physical Sciences)

In the present paper, room-temperature shapes of carbon fiber reinforced plastic (CFRP) laminates are analyzed theoretically by means of classical lamination theory, correspondence principle and anisotropic thermoviscoelastic constitutive equations. The analyzed model was CFRP laminate plate having a stacking sequence. [0°_n/90°_n]. And shapes were calculated under various condition of cooling time.
Development of a Data-driven Condition-Based Maintenance Methodology Framework for an Advanced Jet Trainer

Field: Engineering (Physical Sciences)

Since their introduction more than 20 years ago, PHM strate- gies for aerospace equipment have gone a long way, enabling operators and Original Equipment Manufacturers (OEM) to monitor their assets, track down abnormal behaviors and plan maintenance action in advance. On the other hand, the tran- sition from PHM strategies using simulated data to solutions utilizing real-life operational data is consistently prone to sig- nificant challenges and demands. This doctoral thesis aims to develop a PHM/CBM framework applied to a Electro-Hydraulic Actuators (EHAs) leveraging real in-service fleet data. In this paper, the first steps of the research project are presented.
A Flexible Six-in-One Microsensor Embedded in a Vanadium Redox Flow Battery for Long-Term Monitoring

Field: Energy (Physical Sciences)

The vanadium redox flow battery (VRFB) can be used as a supporting technology for energy storage corresponding to wind and solar power generation. An aqueous vanadium compound solution can be used repeatedly. As the monomer is large, the flow uniformity of electrolytes in the battery is better, the service life is long, and the safety is better. Hence, large-scale electrical energy storage can be achieved. The instability and discontinuity of renewable energy can then be solved. If the VRFB precipitates in the channel, there will be a strong impact on the flow of vanadium electrolyte, and the channel could even be blocked as a result. The factors which influence its performance and life include electrical conductivity, voltage, current, temperature, electrolyte flow, and channel pressure. This study used micro-electro-mechanical systems (MEMS) technology to develop a flexible six-in-one microsensor which can be embedded in the VRFB for microscopic monitoring. The microsensor can perform real-time and simultaneous long-term monitoring of the physical parameters of VRFB, such as electrical conductivity, temperature, voltage, current, flow, and pressure to keep the VRFB system in the best operating condition.
The neutrophil lymphocyte ratio may predict the discharge status in patients admitted to the emergency department

Field: Medicine (Health Sciences)

Objective: The neutrophil to lymphocyte ratio (NLR) has been investigated as an indicator of mortality and/or morbidity in many clinical pathologies. However, these studies have mostly been conducted for specific diseases. We investigated whether there is a relationship between the NLR and hospitalization or discharge decisions in the emergency department (ED). Methods: We retrospectively reviewed the medical records of patients admitted to the ED. The NLR values of the patients were calculated, and their demographic characteristics (age and gender) and clinical outcomes were recorded. Results: Of the 1970 patients, 1400 (71.1%) were discharged from the ED, and 570 (28.9%) were hospitalized. The patients who were discharged were younger and had lower NLR values, and this group had a lower female gender ratio (p<0.001, p<0.001, and p<0.001, respectively). The NLR threshold for discharge was 4.8, with a sensitivity of 70% and a specificity of 60%. Of the 570 hospitalized patients, 478 (83.9%) were discharged from the hospital and 92 (16.1%) died. Deceased patients were statistically significantly older with higher NLR values (p<0.001 and p=0.001, respectively). The threshold value of NLR for predicting mortality was calculated as 11.5, with a sensitivity of 45% and a specificity of 77%. Conclusions: Our study reveals that the NLR is an important predictor of hospitalization and mortality in patients admitted to the ED regardless of diagnosis. ED physicians may consider to discharge patients with NLR values below 4.8 instead of spending additional time with advanced tests. In addition, clinicians should review the risk of mortality in patients with NLR values greater than 11.5 more thoroughly concerning mortality and should consider early aggressive treatment options.
A user-interface for Knuth-Bendix completion

Field: Computer Science (Physical Sciences)

Introduction The Knuth-Bendix completion procedure, or more precisely the family of completion procedures, is at the heart of algebraic theorem proving and equational programming. In a theorem proving setting, it can be used for solving the word problem in a given algebra (is s equal to t modulo some given equations ?) by first trying to determine a convergent rewrite system equivalent to the equations and then rewriting using these rewrite rules. It also provides a semi-decision procedure for solving arbitrary equations (unfailing completion [2]). In a programming environment, it can be seen as a program transformation technique for constructing programs with desired properties (usually convergence, confluence or coherence [10, 16]). Equational programming, or its generalization rewriting logic, is a very high level specification language with a direct operational counterpart, ie. specifications are immediately executable as long as the
Student Views on Literacy in Music Education in Theatre DepartmentsBurcu

Field: Arts and Humanities (Social Sciences)

In this study, it was aimed to examine student views on music education in theater departments. Case study model, which is one of the qualitative research methods, was used in the research. The study group within the scope of the research consists of 10 undergraduate-II students of Trabzon University State Conservatory Performing Arts Department. In order to obtain the data, an interview form prepared by the researcher was created with “Google Form”. Content analysis method was used to analyze the data. According to the data obtained in the study, it was determined that music courses in theater departments in Turkey are mostly “Singing” courses. It was found that the number of music courses in theater departments during undergraduate education is low. According to the opinions of theater students, it was concluded that music education is very important and necessary in their departments. In line with these results, suggestions were made to increase the duration and number of music courses in theater departments.