jimnoneill/paper-to-field-training huggingface dataset:
Clinical efficacy and safety study of Loratadine combined with glucocorticoid nasal spray in the treatment of pediatric bronchial asthma with seasonal allergic rhinitis

Field: Medicine (Health Sciences)

A total of 100 pediatric patients with moderate to severe bronchial asthma and seasonal allergic rhinitis admitted to our hospital between January 2020 and January 2023 were included in this study. All patients met the complete inclusion and exclusion criteria. Based on different treatment interventions, they were divided into the control group (n = 50) and the observation group (n = 50). Patients in the control group received treatment with glucocorticoid nasal spray, while patients in the observation group received combined intervention with Loratadine in addition to the treatment received by the control group. The clinical treatment outcomes, incidence of adverse reactions, as well as the scores of nasal symptoms, asthma control, and peak expiratory flow rates at different treatment time points (baseline, T1: 30 days after treatment, T2: 60 days after treatment, T3: 90 days after treatment) were compared between the two groups. The combined treatment of Loratadine with Glucocorticoid nasal spray demonstrates significant clinical efficacy in the treatment of pediatric bronchial asthma with seasonal allergic rhinitis. It further promotes the recovery of peak expiratory flow rates, improves symptoms of rhinitis and asthma in pediatric patients. Importantly, the application of this combined treatment does not increase the risk of adverse reactions in pediatric patients, indicating its high safety profile. This treatment approach is worthy of clinical application and further promotion.
A single nucleotide variant on chromosome 16 residing within PYCARD distinguishes patients with luminal A breast cancer.

Field: Medicine (Health Sciences)

Molecular subtypes including the most common subtype luminal A drive patient outcomes in human breast cancer but the biological basis for this is not completely understood (1-4). We mined published microarray data (5, 6) to discover in an unbiased fashion the most distinguishing genetic and transcriptional features of tumors of each breast cancer molecular subtype. We identified a single nucleotide polymorphism, rs8056505, residing within PYCARD, as among the most significant genetic differences in the tumors of patients with luminal A breast cancer. In a separate cohort of patients with luminal A subtype breast cancer, we observed differential expression of a PYCARD transcript. Analysis of patient survival data revealed that PYCARD primary tumor expression was correlated with overall survival in patients with basal-like breast cancer. Sequence variation in the PYCARD gene may be important in understanding differences in genetic background that favor development of luminal A subtype human breast cancer.
Holder of Gloucester

Field: Arts and Humanities (Social Sciences)

Journal Article Holder of Gloucester Get access C. B. A. C. B. A. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s12-VII, Issue 141, 25 December 1920, Page 510, https://doi.org/10.1093/nq/s12-VII.141.510i Published: 25 December 1920
Chondromesenchymal Hamartoma With Nasopharyngeal Involvement: Two Unusual Cases of an Extremely Rare Lesion

Field: Medicine (Health Sciences)

Chondromesenchymal hamartoma (CMH) is a rare, benign lesion of the nasal cavity, paranasal sinuses, and skull base, composed of islands of hyaline cartilage in a myxoid background. The vast majority of CMH cases are infants and young children. According to the world literature, nasopharyngeal involvement of CMH is extremely rare. In all cases, the lesions were masses protruding from the nasal cavity or paranasal sinuses to the nasopharynx. We hereby report 2 adult male patients with masses completely situated in the nasopharyngeal space. In the first patient, the tumor originated from the posterior edge of the nasal septum and in the second one, from the posterolateral wall of the nasopharynx, adjacent to the pharyngeal orifice of the Eustachian tube. In both patients, the lesion was excised endoscopically, and histopathological analyses were consistent with a diagnosis of CMH. To our knowledge, those are the only cases of CMH completely situated in the nasopharynx.
Change the Channel

Field: Computer Science (Physical Sciences)

This article presents a new channel model proposed by the International Telecommunication Union- the Radiocommunication Sector (ITU-R) for the evaluation of the International Mobile Telecommunications (IMT)-Advanced radio-access technologies. The model description is based on the perspective of the development of the wide-band multiple-input-multiple output (MIMO) channel models investigated within the European Union (EU)-funded wireless world initiative new radio (WINNER) projects. This article focuses on a soft ware implementation of an IMT-Advanced channel C++ based simulator developed within the CELTIC/EUREKA WINNER+ project at Poznari University of Technology.
Employees' perceptions of the Aid-for-AIDS disease-management programme, South Africa

Field: Health Professions (Health Sciences)

It is estimated that 18-20% of South Africa's more than 5 million HIV-positive individuals are formally employed. Disease management programmes for these employees vary in scope and sophistication, with services provided by the employer, or third-party specialist disease managers, or through medical aid schemes. This study surveyed 215 HIV-positive employees in two organisations contracted to the Aid for AIDS (AfA) disease management programme through their in-house medical aid schemes. The two organisations differed in their overall approach to HIV and AIDS: one mainly relies on on-site access to voluntary counselling and testing (VCT) and AfA's management of registered HIV-positive employees, while the other has invested in and actively developed a comprehensive programme that also extends to families and the community as well as links employees to the AfA programme. Responses received from 28 of the 215 employees surveyed indicate that fear of disclosure of one's HIV status and of stigmatisation are reasons for late registration with the AfA programme or non-utilisation of other available support programmes. Respondents mentioned that confidence in the employer's ability to maintain confidentiality was also an issue. Respondents' important suggestions for change included: a) on-site educational and awareness programmes for management personnel and staff in order to reduce HIV discrimination and stigmatisation; b) information directed at HIV-positive employees publicising the benefits and effectiveness of medical treatment; c) support groups for HIV-positive employees; and d) management personnel to engage with HIV-infected employees who are willing to take an active role in staff education and the development of workplace policies and programmes.
Depatriarchise design *!Labs!*

Field: Arts and Humanities (Social Sciences)

opinion Share on Depatriarchise design *!Labs!*: transforming design education Authors: Anja Neidhardt View Profile , Maya Ober View Profile Authors Info & Claims InteractionsVolume 27Issue 6November - December 2020 pp 18–21https://doi.org/10.1145/3430650Published:02 November 2020Publication History 0citation454DownloadsMetricsTotal Citations0Total Downloads454Last 12 Months99Last 6 weeks19 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Distribution of intestine-associated lymphoid tissue, aberrant crypt foci, and tumors in the large bowel of 1,2-dimethylhydrazine-treated mice

Field: Medicine (Health Sciences)

The full text of this article is not available in SOAR. WSU users can access the article via commercial databases licensed by University Libraries: http://libcat.wichita.edu/vwebv/holdingsInfo?bibId=1381109. The URL of this article is: http://cancerres.aacrjournals.org/content/54/16/4304.full.pdf+html?sid=caaab144-e927-4073-aa96-3c7e1d93f93e.
Obama asks Congress "to finish its work" on health reform

Field: Social Sciences (Social Sciences)

President Barack Obama has pushed forward on US health reform, calling on Congress to finish the work it had almost completed after more than a year of debate.

He expressed the hope of getting a final bill passed within weeks and indicated that he would use a complicated procedure called reconciliation to do it.

Americans are divided on health reform, with many fearing a government takeover of health care. The president’s prestige and the fate of the Democrats in the November 2010 elections may hang on health reform. All seats in the House of Representatives are up for election in November, as are a third of Senate seats.

“I believe the United States Congress owes the American people a final vote on healthcare reform . . . Reform has already passed the House with a majority. It has already passed the Senate with a super-majority of 60 votes,” said President Obama. Now was the time for Congress to vote yes or no.

Standing among white coated medical professionals at a White House meeting, he said, “Every idea …
Treatment of thyroid dysfunction in a medical specialist’s office – the role of levothyroxine

Field: Medicine (Health Sciences)

Synthetic levothyroxine is the first line treatment for hypothyroidism, one of the most common endocrine disorders, independently its cause, in all age groups. The Polish Endocrinological Society, together with European Thyroid Association, American Thyroid Association and American Association of Clinical Endocrinologists, do not recommend the use of dried thyroid preparations, triiodothyronine or combined preparations of thyroxine with triiodothyronine. The objective of treatment is to achieve biochemical and clinical euthyroidism monitored by TSH and/or FT4 levels. The daily dose of levothyroxine depends on many factors, including the etiology and severity of hypothyroidism, age, body weight, pregnancy and comorbidities. Routinely, levothyroxine is administered on an empty stomach at least 30 minutes before breakfast (ATA 2014 recommend up to 60 minutes interval between meal and taking the drug). Levothyroxine can also be used in combination therapy in Graves’ disease. Currently, the routine use of synthetic sodium levothyroxine in patients with multinodular goiter is not recommended because it increases the risk of osteoporosis in postmenopausal women and atrial fibrillation in patients after 60 year of life.
SU‐E‐I‐04: Improving CT Quality for Radiation Therapy of Patients with High Body Mass Index Using Iterative Reconstruction Algorithms

Field: Medicine (Health Sciences)

Purpose: Iterative reconstruction (IR) algorithms are developed to improve CT image quality (IQ) by reducing noise without diminishing spatial resolution or contrast. The CT IQ for patients with a high Body Mass Index (BMI) can suffer from increased noise due to photon starvation. The purpose of this study is to investigate and to quantify the IQ enhancement for high BMI patients through the application of IR algorithms. Methods: CT raw data collected for 6 radiotherapy (RT) patients with BMI, greater than or equal to 30 were retrospectively analyzed. All CT data were acquired using a CT scanner (Somaton Definition AS Open, Siemens) installed in a linac room (CT‐on‐rails) using standard imaging protocols. The CT data were reconstructed using the Sinogram Affirmed Iterative Reconstruction (SAFIRE) and Filtered Back Projection (FBP) methods. IQ metrics of the obtained CTs were compared and correlated with patient depth and BMI. The patient depth was defined as the largest distance from anterior to posterior along the bilateral symmetry axis. Results: IR techniques are demonstrated to preserve contrast and reduce noise in comparison to traditional FBP. Driven by the reduction in noise, the contrast to noise ratio is roughly doubled by adopting the highest SAFIRE strength. A significant correlation was observed between patient depth and IR noise reduction through Pearson's correlation test (R = 0.9429/P = 0.0167). The mean patient depth was 30.4 cm and the average relative noise reduction for the strongest iterative reconstruction was 55%. Conclusion: The IR techniques produce a measureable enhancement to CT IQ by reducing the noise. Dramatic noise reduction is evident for the high BMI patients. The improved CT IQ enables more accurate delineation of tumors and organs at risk and more accuarte dose calculations for RT planning and delivery guidance. Supported by Siemens
Death from Pressure Ulcer

Field: Health Professions (Health Sciences)

Why wasn't Mr. Daly referred to hospice care? Hospice provides an extra layer of care for terminally ill patients and eases a nursing home's heavy burden of patient care. Hospice nurses and physicians are experts in end-of-life care, including pain and symptom management as well as wound care consultation. A hospice nurse could have created a pain management routine that met this patient's needs and advocated on his behalf when medications weren't given on time or when the plan of care wasn't followed. Home health aides could have provided assistance with bathing and feeding, and their plans of care could have been tailored in ways that would have best assisted Mr. Daly, his family, and the staff. Social workers, chaplains, and volunteers could have visited with and provided additional emotional support for the patient and his family. Michelle Sabree, MSN, RN, CNAA, CHPN Newnan, GA
Comparative Analysis of Different AI Approaches to Stroke Patients’ Gait Analysis

Field: Computer Science (Physical Sciences)

Despite advances in diagnostics, the objective and repeatable assessment of patients with neurological deficits (e.g., stroke) remains a major challenge. Modern methods based on artificial intelligence (AI) are of interest to researchers and clinicians in this area. This study presents a comparative analysis of different AI approaches used to analyze gait of stroke patients using a retrospective dataset of 120 individuals. The main objective is to evaluate the effectiveness, accuracy, and clinical relevance of machine learning (ML) and deep learning (DL) models in identifying gait abnormalities and predicting rehabilitation outcomes. Multiple AI techniques—including support vector machines (SVM), random forests (RF), k-nearest neighbors (k-NN), and convolutional neural networks (CNN)—were trained and tested on time-series gait data with spatiotemporal parameters. Performance metrics such as accuracy, precision, recall, and area under the curve (AUC) were used to compare model results. Initial results indicate that DL models, particularly CNNs, outperform traditional ML methods in capturing complex gait patterns and providing reliable classification. However, simpler models showed advantages in interpretability and computational efficiency. This study highlights the potential and shortcomings of AI-based gait analysis tools in supporting clinical decision-making and planning personalized stroke rehabilitation.
Generation of global 1 km all-weather instantaneous and daily mean land surface temperatures from MODIS data

Field: Environmental Science (Physical Sciences)

Abstract. Land surface temperature (LST) serves as a crucial variable in characterizing climatological, agricultural, ecological, and hydrological processes. Thermal infrared (TIR) remote sensing provides high temporal and spatial resolutions for obtaining LST information. Nevertheless, TIR-based satellite LST products frequently exhibit missing values due to cloud interference. Prior research on estimating all-weather instantaneous LST has predominantly concentrated on regional or continental scales. This study involved generating a global all-weather instantaneous and daily mean LST product spanning from 2000 to 2020 using XGBoost. Multisource data, including Moderate-Resolution Imaging Spectroradiometer (MODIS) top-of-atmosphere (TOA) observations, surface radiation products, and reanalysis data, were employed. Validation using an independent dataset of 77 individual stations demonstrated the high accuracy of our products, yielding root mean squared errors (RMSEs) of 2.787 K (instantaneous) and 2.175 K (daily). The RMSE for clear-sky conditions was 2.614 K for the instantaneous product, which is slightly lower than the cloudy-sky RMSE of 2.931 K. Our instantaneous and daily mean LST products exhibit higher accuracy compared to the MODIS official LST product (instantaneous RMSE = 3.583 K; daily 3.105 K) and the land component of the fifth generation of the European ReAnalysis (ERA5-Land) LST product (instantaneous RMSE = 4.048 K; daily 2.988 K). Significant improvements are observed in our LST product, notably at high latitudes, compared to the official MODIS LST product. The LST dataset from 2000 to 2020 at the monthly scale, the daily mean LST on the first day of 2010 can be freely downloaded from https://doi.org/10.5281/zenodo.4292068 (Li et al., 2024), and the complete product will be available at https://glass-product.bnu.edu.cn/ (last access: 22 August 2024).
Amelioration by Ingestion of Phenylalanine of Toxic Effects of Chloramphenicol on Bone Marrow

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

THE major toxic effect of chloramphenicol is the production of bone-marrow arrest and aplastic anemia. Early in the development of chloramphenicol toxicity, vacuoles appear in the erythroid and myeloid precursors of the bone marrow.1 2 3 4 The relation of these early, reversible lesions to later, more serious bone-marrow depression is unknown. Similar cytoplasmic vacuoles in the erythrogones have been reported in erythremic myelosis (Di Guglielmo's syndrome) and acute alcoholism, and in normal infants as well as those with phenylketonuria receiving a phenylalanine-deficient diet.5 6 7 8 The lesions in the infants receiving such diets were reversed by the addition of phenylalanine. Therefore, an attempt was . . .
The GoalProject: A Group Assignment to Encourage Creative Thinking, Leadership Abilities and Communication Skills

Field: Business, Management and Accounting (Social Sciences)

The classroom assignment described in this paper, The Goal Project, gives students an opportunity to develop four of the skills and abilities required to be a successful accountant. In 1990, the Accounting Education Change Commission issued Position Statement Number One, Objectives of Education for Accountants. Appendix B of that statement contains eight categories of knowledge, skills, personal capacities and attitudes that are needed by accounting graduates. The Institute of Management Accountants has outlined the work of a management accountant to include working in small business teams and participating in strategic decision making. The project described in this paper replicates the work an accountant would perform when working in problem-solving teams. Data was collected and results are included from a questionnaire completed by 166 students who participated in The Goal Project. The results of perceived improvement in creative problem solving, leadership skills, and oral and written communication skills are presented.
miR‐143 targets MAPK7 in CHO cells and induces a hyperproductive phenotype to enhance production of difficult‐to‐express proteins

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

In recent years, the number of complex but clinically effective biologicals such as multi‐specific antibody formats and fusion proteins has increased dramatically. However, compared to classical monoclonal antibodies (mAbs), these rather artificially designed therapeutic proteins have never undergone millions of years of evolution and thus often turn out to be difficult‐to‐express using mammalian expression systems such as Chinese hamster ovary (CHO) cells. To provide access to these sophisticated but effective drugs, host cell engineering of CHO production cell lines represents a promising approach to overcome low production yields. MicroRNAs (miRNAs) have recently gained much attention as next‐generation cell engineering tools. However, only very little is known about the capability of miRNAs to specifically increase production of difficult‐to‐express proteins. In a previous study we identified miR‐143 amongst others to improve protein production in CHO cells. Thus, the aim of the present study was to examine if miR‐143 might be suitable to improve production of low yield protein candidates. Both transient and stable overexpression of miR‐143 significantly improved protein production without negatively affecting cell growth and viability of different recombinant CHO cells. In addition, mitogen‐activated protein kinase 7 (MAPK7) was identified as a putative target gene of miR‐143‐3p in CHO cells. Finally, siRNA‐mediated knock‐down of MAPK7 could be demonstrated to phenocopy pro‐productive effects of miR‐143. In summary, our data suggest that miR‐143 might represent a novel genetic element to enhance production of difficult‐to‐express proteins in CHO cells which may be partly mediated by down‐regulation of MAPK7. © 2017 American Institute of Chemical Engineers Biotechnol. Prog. , 33:1046–1058, 2017
PHARMACOLOGICAL THERAPEUTIC MONITORING OF MYCOPHENOLATE MOFETIL (MMF) IN AUTOIMMUNE DISEASES AT EHU OF ORAN-ALGERIA : CONTRIBUTION OF PHARMACEUTICAL INTERVENTIONS

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Introduction: Mycophenolate mofetil (MMF) is an immunosuppressant indicated for organ transplantation and other autoimmune diseases. The pharmacological therapeutic monitoring (PTM) of the MMF based on the measurement of the area under the curve (AUC) is justified. Objective: The objective of our study was to evaluate the contribution of pharmaceutical interventions emitted during MMF PTM of patients with autoimmune diseases in the pharmacovigilance service of the EHU of Oran-Algeria. Material and Methods: This is a retrospective descriptive study of 5 years, dealing with patients treated by MMF for all autoimmune diseases in pharmacovigilance service of the EHU of Oran-Algeria. In total, 60 patients were monitored. The average age of the study population was 29.81 years with a female predominance of 56.66% (sex ratio 0.7). Result and Discussion: In our study lupus nephropathy represents the most common pathology with a rate of 51.67%, followed by nephrotic syndrome with 41.67%. 106 AUC were measured, 37.74% were below 30 mg.h / l, 49.06% were between 30 and 60 mg.h / l and 13.20% of the AUC were above 60 mg / h. / l. The signs of intolerance observed were: 60.42% of the disturbances of the hemogram, 16.67% of the various infections, 12.5% of the cutaneous affections and 10.41% of the digestive disorders. Various pharmaceutical opinions have been issued to manage this drug iatrogenic. Conclusion: The results of our study show that PTM has a major interest in predicting of response to MMF in autoimmune diseases. The application of MMF PTM in routine clinical practice should be generalized to adjust the dosage of MMF to improve the efficacy and reduce the adverse effects of this drug.