jimnoneill/paper-to-field-training huggingface dataset:
Boosting Students’ Speaking skill using Ted Talks YouTube Videos: Teacher Talk Theory

Field: Arts and Humanities (Social Sciences)

<p><em>Even though the importance of teaching English speaking using TED Talks to improve students’ speaking skill has been acknowledged, however, far too little attention has been paid to investigate students’ perceptions on the use of TED Talks dealing with teacher talk categories such as dealing with feelings, praising and encouraging, making joke, as well as giving direction and lecturing. This study aimed to investigate the concordance of the students’ speech ability development and the students’ interest and motivation towards the use of TED Talks to boost the students’ speaking skill. This present used both quantitative and qualitative design. The samples of the students were 27 students from grade 7E in MTsN Surabaya. For the quantitative data, the data was collected using pre-test and post-test. However, for the qualitative data, the data was gathered using interview protocol. The data was analyzed using descriptive analysis. The findings of this study found that the students improve their English speaking skill especially the pronunciation and the fluency of delivering English speech in front of their friends after the treatment using the TED Talks videos. Regarding the students’ perceptions of the use TED Talks to support teacher talks, most of the students agreed that TED Talks videos can support teacher talks related to the category of dealing with feelings, praising and encouraging, making jokes and giving direction as well as lecturing.</em></p>
Biologic anticancer activity of designed ankyrin repeat proteins (darpins) targeted against dnmt1 and conjugated to docetaxel leads to eradication of chemoresistant mutated squamous cell epsophageal cancer stem cells

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Introduction Current anticancer therapies succeed at eradicating bulky disease but miss a tumour reservoir consisting of stem/progenitor cells (SCs) that lead to disease recurrence and metastasis. Tumour stem cells are characterised by upregulation of hTERT which is the limiting factor for telomerase activity. DNA methylation leads to hTERT gene expression. Methods We obtain specimens of surgically resected oesophageal Ca from distant lymph node metastatic sites from patients chemoresistant to vinca alkaloids like vinorelbine-tartrate, and isolate the mutated tumour stem cells. We treat them with DARPins targeting DNMT1 conjugated to docetaxel. Results Post-treatment, we observed downregulation of DNMT1 blocking methylation of hTERT promoter inhibiting its transcription and subsequent telomerase activity. Stem cell markers p63, CD44, CD117, CD90, CD133, BCRP1, b-catenin and methylation marker SCNN1B were downregulated. After DNA demethylation, there was upregulation of thymosin b10, p16/Rb, RASSF2, p53 and PTEN lipid/protein phosphatase. Subsequently, there was inhibition of chemoresistant factors, such as choline-kinase, PI3K-AKT/PKB-mTOR, Ras/Raf/Erk/TGFa/EGFR, COX-2, PGE2, PDGF, VEGF, cyclin D1, HIF-1a, survivin and aurora – A/STK15/BTAK. There was enhancement in adheren junction formation. Docetaxel polymerised microtubules blocking cell cycle at G2/M while it phosphorylated antiapoptotic bcl-2 upregulating tumour suppressor gene beclin1 which induced autophagy. Activation of procaspase 10 and procaspase 8 formed DISC which induced type I, II and III PCD and aponecrosis of mutated tumour stem cells. Conclusion Combination of molecularly targeted therapies such as DARPins and conventional cytostatic agents such as docetaxel could provide a potent strategy to eradicate metastatic mutated ESCC stem cells resistant to conventional chemotherapy with vinca alkaloids such as vinorelbine.
The Dynamics of Pedagogic Judgment in Teaching.

Field: Arts and Humanities (Social Sciences)

In the school culture, teachers are often caught between sanctioned instructional behavior and their own judgment; governed by legislated edicts, yet not freed by them to nurture their students. The relationship between pedagogic actions and morally acceptable outcomes, between responsibility to the self and to the students, the school, and the community is frequently perceived by reflective teachers to be in flux, confounding their daily judgments and classroom instruction. Through pedagogic judgments, teachers interpret and guide the enactment of their teaching, transforming theoretical constructs into relational understandings and technical concerns into morally expressive actions. Typically, students trust in their teachers' willingness to act in appropriate and equitable ways. Teachers must have an advocative attitude, with empathy for students' capacity to view the subject matter being taught. Inasmuch as students accept the teacher's offer of relationship as authentic, they are able to accept the teacher's presentation of the world, whether of history, math algorithms, or the moral implications of modeled adult classroom behavior. The effects of pedagogic judgment that arise from egocentric, or even casual behavior, may be the most destructive lessons taught. Attending to students requires an expansion to an inclusive, advocative self in the world of outside cause and effects. Inquiry will establish a compelling recognition of the moral in the beliefs, perceptions, reasoning, and actions that are associated with teacher judgment. Pedagogic judgment happens when the moral dimensions of teaching are recognized and the relationship between teacher and student is enabled. (Contains 24 references.) (SM) ******************************************************************************** * Reproductions supplied by EDRS are the best that can be made * * from the original document. * ******************************************************************************** The Dynamics of Pedagogic Judgment in Teaching Dayvid Schultz AREA 1998 Annual Meeting
Music and Literature: Ethel Smyth, Virginia Woolf, and "The First Woman to Write an Opera"

Field: Arts and Humanities (Social Sciences)

I'm awfully proud—thats not the right phrase—that you've started again on the autobiography, partly owing to me. I was thinking the other night that there's never been a womans autobiography. Nothing to compare with Rousseau. Chastity and modesty I suppose have been the reason. Now why shouldnt you be not only the first woman to write an opera, but equally the first to tell the truths about herself? Isnt the great artist the only person to tell the truth? I should like an analysis of your sex life. As Rousseau did his. More introspection. More intimacy. I leave it to you; for as you see I cant make my pen take my ply this cold morning. Ethel Smyth's (1858–1944) later life was significantly enlivened by her frequent contact with Virginia Woolf (1882–1941), from which a fruitful, if sometimes strained, friendship blossomed that was curtailed by Woolf's suicide in March 1941. By the time of their first meeting in February 1930, Smyth, having overcome substantial opposition to her chosen career path and challenged traditional notions of the place of women within music composition internationally, had written six operas, a Mass, and many other chamber, orchestral, and vocal works, and was working on what was to be her last major composition, her oratorio The Prison.1 Her increasing deafness may have compelled her to develop a secondary career as writer of memoirs, biographical and other sketches, as well as polemical essays,2 but music remained her greatest passion, her first “string,” and her “real love.”3 Woolf had similarly attained the professional success that established her as a pioneering modernist by 1930, having published the first six of her nine novels, as well as many newspaper articles, book reviews, and other essays (some of which were collected in her anthology The Common Reader, the first volume of which had appeared in 1925), including her foundational feminist polemic, A Room of One's Own (1929).4 Investigation of the continuing intellectual dialogue that took place between these two pathbreaking artists enriches our understanding of wider differences between the disciplines of music and literature, their histories, canons, and art, as well as revealing much about the underrepresentation of women that both felt acutely, and against which they campaigned fervently in their writings.
The Taonga of the New Zealand Association of Psychotherapists

Field: Arts and Humanities (Social Sciences)

In this paper the importance of the taonga, treasures, of the New Zealand Association of Psychotherapists, representing the four directions and balance, is explained. Included is how they were used in the opening and closing ceremonies at the Conference in Nelson, 2017. The purpose of this paper is to keep their awareness alive in our Association. WhakarāpopotongaKo tā tēnei tuhinga, he whakatairanga i ngā taonga ā Te Roopū Whakaora Hinengaro o Aotearoa, te whakamārama hoki i ngā ahunga me te whakatairitenga mai i ngā hua e whā. Ka tāpirihia te whakatinanatanga o ēnei i te whakatuwheratanga me nga katinga o te Hui Wānanga i Whakatū i te tau 2017. Ko te kaupapa o tā tēnei pepa he whakamau ake i tō rātau aroā i roto i tō tātau Roopū.
Effect of Apoptosis Induction of Ailanthus altissima on Human Lung Carcinoma Cells

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

We investigated the inhibitory effects of solvent extracts from Ailanthus altissima in A549 human lung cancer cell. A. altissima has been recognized as a traditional healthy food due to its various biological activities against hypertension, strokes, fever, pain, neuralgia, inflammation, and cancer effects. Recently, it has been reported that the extracts of various wild vegetables show strong anti-cancer properties by induction of apoptosis. However, the mechanisms of their cytotoxicity in human lung cancer cells have been poorly understood. The present study was investigated the effects of solvent extracts from A. altissima on cell growth and apoptosis on A549 human lung cancer cells. A treatment of A. altissima inhibited the growth of A549 cells in a dose-dependent manner by inducing apoptosis. Especially, the chloroform fraction showed the highest anti-cancer effect among five kinds of fractions. And also, induction of apoptosis by chloroform fraction were associated with down-regulation of Bcl-2, and up-regulation of pro-apoptotic Bax expression. From these results, A. altissima may have a therapeutic potential in human lung cancer cells and as a functional food.
Hydrocephalus: Current State of Diagnostics and Treatment

Field: Medicine (Health Sciences)

Hydrocephalus, the accumulation of cerebrospinal fluid in the brain’s ventricles, has numerous difficulties regarding diagnosis, treatment, and patient care. This article provides a comprehensive analysis of the condition, including the areas of current therapeutic options, surgical intervention (implementation of shunts/ third ventriculostomies), and novel therapeutic approaches including inhibition of NKCC1 and modulation of PKC. This paper also discusses noninvasive treatments like gene therapy and “smart shunt” systems. From a global perspective, it is revealed that there are numerous disparities regarding hydrocephalus and its treatment modalities. This very aspect forms the basis for special healthcare programs to cater to these global inequalities. This study bedevils us with the fact of how intricate hydrocephalus management is, a complication that is mostly determined by a specific country’s healthcare infrastructure. The region's funding, health facilities, and cultural issues also are used to showcase hydrocephalus causes and effects. Furthermore, there is a large focus on patient care and also a meticulous presentation of subsequent care strategies and rehabilitation with the family's support to improve the results for those who are afflicted with the disease. This article concludes with a call to go beyond research in this area with the international cooperation that will lead to comprehending this challenge and the multidisciplinary problems and opportunities that come along with it. This research study provides an indispensable contribution to the fields of neurology and healthcare, and this adds value in terms of the care and treatment of hydrocephalus by facilitating its understanding on a scientific basis for students and healthcare professionals around the world.
Motivating freshmen engineering students

Field: Engineering (Physical Sciences)

In an effort to lower the rate of attrition of Engineering students, during the early years of their education, the University of Nebraska - Lincoln has instituted a series of two freshman engineering courses which are designed to motivate and retain these students. A description of each of these courses and the motivating factors of each are discussed. Creative plots and conceptual engineering design projects are used as a means of holding interest and teaching the basic engineering skills. Surveys taken over a number of years have shown an increase in the retention of engineering students since these courses were instituted. These surveys are discussed.
Data from <i>PIK3CA</i> Mutations in Patients with Advanced Cancers Treated with PI3K/AKT/mTOR Axis Inhibitors

Field: Medicine (Health Sciences)

<div>Abstract<p>Preclinical data suggest that <i>PIK3CA</i> mutations predict response to PI3K/AKT/mTOR inhibitors. Concomitant <i>KRAS</i> or <i>BRAF</i> mutations may mediate resistance. Therefore, tumors from patients referred to the phase I program for targeted therapy starting in October 2008 were analyzed for <i>PIK3CA</i> mutations using PCR-based DNA sequencing of exons 9 and 20. Consecutive patients with diverse tumor types and <i>PIK3CA</i> mutation were treated whenever possible with agents targeting the PI3K/AKT/mTOR pathway. Overall, <i>PIK3CA</i> mutations were detected in 25 of 217 patients (11.5%; exon 9, <i>n</i> = 11; exon 20, <i>n</i> = 14). In tumor types with more than 10 patients tested, <i>PIK3CA</i> mutations were most frequent in endometrial (3 of 14, 21%), ovarian (5 of 30, 17%), colorectal (9 of 54, 17%), breast (2 of 14, 14%), cervical (2 of 15, 13%), and squamous cell cancer of the head and neck (1 of 11, 9%). Of the 25 patients with <i>PIK3CA</i> mutations, 17 (68%) were treated on a protocol that included a PI3K/AKT/mTOR pathway inhibitor, and 6 (35%) achieved a partial response. In contrast, only 15 of 241 patients (6%) without documented <i>PIK3CA</i> mutations treated on the same protocols responded (<i>P</i> = 0.001). Of the 17 patients with <i>PIK3CA</i> mutations, 6 (35%) had simultaneous <i>KRAS</i> or <i>BRAF</i> mutations (colorectal, <i>n</i> = 4; ovarian, <i>n</i> = 2). Colorectal cancer patients with <i>PIK3CA</i> and <i>KRAS</i> mutations did not respond to therapy, whereas both ovarian cancer patients with <i>PIK3CA</i> and <i>KRAS</i> or <i>BRAF</i> mutations did. In conclusion, <i>PIK3CA</i> mutations were detected in 11.5% of patients with diverse solid tumors. The response rate was significantly higher for patients with <i>PIK3CA</i> mutations treated with PI3K/AKT/mTOR pathway inhibitors than for those without documented mutations. <i>Mol Cancer Ther; 10(3); 558–65. ©2011 AACR</i>.</p></div>
Progress In Coherent Optical Fibre Transmission Techniques In The United Kingdom

Field: Engineering (Physical Sciences)

The initial reason for investigating coherent optical fibre transmission techniques was to determine if the predicted improvements in receiver sensitivity of between 10 to 20 dB over direct detection (1,2) could be achieved in a laboratory experiment. There had been several areas of doubt about the practicability of coherent detection, in particular the spectral properties of semiconductor laser sources, the polarisation characteristics of the fibre transmission medium, the increased complexity of a coherent transmission system and the extensive engineering development that is necessary. Once the practical problems have been reconciled a future for coherent transmission could be forseen, not just for point-to-point long haul telecommunications, but also for wideband signal distribution in local networks. For this second application the extra sensitivity of coherent detection would largely overcome optical path splitting losses and the selectivity of coherent detection could allow many thousands of channels to be frequency multiplexed with a spacing not attainable by other techniques.
Proceedings of the 2nd International Workshop on Intelligent Exploration of Semantic Data

Field: Computer Science (Physical Sciences)

Welcome to the 2013 workshop on Intelligent Exploration of Semantic Data (IESD). IESD workshop series focuses on approaches for exploring semantic data. Semantic data is available widely and semantic data exploration is becoming a key activity in a range of application domains. Several novel interfaces and interaction means for exploration of semantic data are being proposed, for example semantic data browsers, ontology/content visualisation environments and semantic wikis. Although on the rise, the current solutions are still maturing and need to take into account human factors to make exploration intuitive or employ necessary computational models to aid the intuitiveness and improve the effectiveness of exploration tasks. Lessons also can be learned from the commonalities and differences in exploration requirements between different domains. Hence, greater benefits can be achieved by bringing together expertise from different communities, including HCI, Semantic Web, and personalisation with the potential application domain demands. IESD workshop series aims to bring together such disciplines related to semantic data exploration and form an international community to identify the major challenges and research directions.
Beam loss monitoring through emittance growth control and feedback with design

Field: Physics and Astronomy (Physical Sciences)

Beam intensities and powers being increasingly strong, installations increasingly large, the need to reduce losses and costs (i.e. dimensions) becomes essential. Improvements are possible by increasing the acceptance in the two transverse planes. For example for LEBT lines and radioactive beams, a large geometric acceptance allows efficient transport of reaction products that have large phase space dimensions downstream of the TIS. For low intensities, the flux is preserved to allow maximum intensity on target (reactions with low cross section). We investigate the solution to control the beam line acceptance by measuring the emittance growth and a feedback with the design, e.g. pole shape and high-order modes of the fields. This is possible with detection of very low intensities of the halo and beam loss monitoring.
Action in Development

Field: Psychology (Social Sciences)

Infant motor skill acquisition is so rapid and dramatic that a century of researchers – and eons of parents – have marveled at the scope of developmental change. At birth, infants are essentially prisoners of gravity, unable to lift their heads from their caregivers' chest. But by 2 years of age, infants can "pluck a pellet with fine pincer prehension" (Gesell, 1929, p. 132) and race on two feet across the living room floor. This remarkable transformation in action characterizes the development of basic motor skills – posture for supporting the body against gravitational and inertial forces, manual skills for interacting with objects and surfaces, and locomotion for moving the body through the environment (Adolph & Berger, 2015).
Physical and structural properties of Dy3+ and Nd3+-ions doped oxy-fluoride glasses

Field: Materials Science (Physical Sciences)

Glasses containing potassium-zinc-boro-oxy-fluoride glasses were doped with Dy3+ and Nd3+-ions. For more incite the prepared glasses physical properties and structural studies analyzed. Refractive index nearly 1.62 is obtained for all glasses resulting in optical behaviour representing nature of the glasses. The single doped and co-doped systems represent not many changes in structural modes.
K3 surfaces with 9 cusps in characteristic p

Field: Mathematics (Physical Sciences)

We study K3 surfaces with 9 cusps, i.e. 9 disjoint $A_2$ configurations of smooth rational curves, over algebraically closed fields of characteristic $p\neq 3$. Much like in the complex situation studied by Barth, we prove that each such surface admits a triple covering by an abelian surface. Conversely, we determine which abelian surfaces with order three automorphisms give rise to K3 surfaces. We also investigate how K3 surfaces with 9 cusps hit the supersingular locus.
Beyond Technocratic Debates: The Significance and Transience of Political Incentives in the Malawi Farm Input Subsidy Programme (FISP)

Field: Social Sciences (Social Sciences)

The Malawi FISP resurrected debates about the role of subsidies in African agricultural policy. Recent literature has highlighted the social and political interests that influence the distribution of input‐subsidy vouchers, often tending to reduce the efficiency with which such programmes contribute to poverty reduction. Taking the FISP as a case study, this article examines the political incentives that have driven programme implementation. Two streams of rents associated with the FISP were used to generate support for the first‐term government of President Mutharika (2005–9), with very different implications for programme efficiency. One then stopped abruptly in 2009. The Malawi case demonstrates both the importance of political incentives in determining subsidy outcomes and how they can change dramatically over time.
Cometary topography and phase darkening

Field: Physics and Astronomy (Physical Sciences)

\nAims. Cometary surfaces can change significantly and rapidly as a result of the sublimation of their volatile material. Many authors have investigated this evolution; topographic data from all comets visited by spacecrafts have been used previously to derive a quantitative model that relates large-scale roughness (i.e. topography) with the evolution state of the nucleus for Jupiter-family comets (JFCs). Ground-based observers have published measurements of the phase functions of many JFCs and reported a trend in the phase darkening, with primitive objects showing a stronger darkening than evolved objects.\nMethods. We used a numerical implementation of this previous topographic description to build virtual comets and measure the phase darkening induced by the different levels of macro-roughness. We then compared our model with other published values.\nResults. We find that pure geometric effects such as self-shadowing can represent up to 22% of the darkening that is observed for more primitive objects, and 15% for evolved surfaces. This shows that although physical and chemical properties remain the main contributor to the phase darkening, the additional effect of the topography cannot be neglected.\n
Secondary emission monitor for low-interception monitoring (SLIM): an innovative nondestructive beam monitor for the extraction lines of a hadrontherapy center

Field: Engineering (Physical Sciences)

Real-time monitoring of hadrontherapy beam intensities and profiles is a critical issue for the optimization of the dose delivery to the patient tumour tissue, the patient safety, and the operation of the accelerator complex. For this purpose, an innovative beam monitor, based on the secondary emission of electrons by a nonperturbative, submicrometer-thick Al target placed directly in the extracted beam path, is being proposed. The secondary electrons, accelerated by an electrostatic focusing system, are detected by a monolithic silicon position sensitive sensor, which provides the beam intensity and position with a precision of 1 mm at a 10-kHz frame rate. The conceptual design and the engineering study optimized for hadrontherapy are presented together with the results of the laboratory tests with thermoionic electrons and the first measurements in a hadron beam.