jimnoneill/paper-to-field-training huggingface dataset:
Planning a Multi‐site, Complex Intervention for Homeless People with Mental Illness: The Relationships Between the National Team and Local Sites in Canada's At Home/Chez Soi Project

Field: Social Sciences (Social Sciences)

Abstract This research focused on the relationships between a national team and five project sites across Canada in planning a complex, community intervention for homeless people with mental illness called At Home/Chez Soi, which is based on the Housing First model. The research addressed two questions: (a) what are the challenges in planning? and (b) what factors that helped or hindered moving project planning forward? Using qualitative methods, 149 national, provincial, and local stakeholders participated in key informant or focus group interviews. We found that planning entails not only intervention and research tasks, but also relational processes that occur within an ecology of time, local context, and values. More specifically, the relationships between the national team and the project sites can be conceptualized as a collaborative process in which national and local partners bring different agendas to the planning process and must therefore listen to, negotiate, discuss, and compromise with one another. A collaborative process that involves power‐sharing and having project coordinators at each site helped to bridge the differences between these two stakeholder groups, to find common ground, and to accomplish planning tasks within a compressed time frame. While local context and culture pushed towards unique adaptations of Housing First, the principles of the Housing First model provided a foundation for a common approach across sites and interventions. The implications of the findings for future planning and research of multi‐site, complex, community interventions are noted.
ChemInform Abstract: Terminal Aminophosphinidene Complexes. A New Approach.

Field: Chemistry (Physical Sciences)

Abstract The thermal decomposition of the (amino)phosphirene‐W complex (I) at ca. 130 °C provides an access to the transient (amino)phosphinidene‐W compound (II) which is trapped by 2,3‐dimethylbutadiene (III), EtOH, or NHEt 2 (V) to give the expected adducts (IV) and (VI).
Area-selective atomic layer deposition enabled by competitive adsorption

Field: Materials Science (Physical Sciences)

In this work, we investigate the atomic layer deposition (ALD) of ZrO2 thin films on Cu and SiO2 substrates, using Zr[N(C2H5CH3)]4 as the thin-film precursor, and H2O or O2 as the coreactants. Here, we introduce 3-hexyne as a coadsorbate molecule during the thin-film precursor half-cycle and examine its effect on the selectivity of growth. We find that 3-hexyne strongly inhibits growth on Cu, while having essentially no effect on the growth on SiO2. Calculations using dispersion-inclusive density functional theory verify that 3-hexyne undergoes sp → sp2 rehybridization on Cu, which results in strong chemisorption on the metal surface, while only binding weakly to SiO2 via nonbonded van der Waals/dispersion interactions. After 10 cycles of ALD using 3-hexyne as the coadsorbate, we observed the deposition of ∼1.5 nm of ZrO2 on SiO2. On a Cu substrate, we only detected &lt;0.15 nm of ZrO2 after the same number of cycles of ALD. At this point in the process, we find evidence of the formation of cuprous oxide (Cu2O) from in situ x-ray photoelectron spectroscopy and a significant increase in the roughness of the Cu substrate. We conclude that both factors likely contribute to the loss of selectivity due to the formation of sites (e.g., Cu2O) that bind 3-hexyne less strongly and/or an increase in the density of highly reactive sites (e.g., steps, kinks) that promote dissociative chemisorption of the thin-film precursor.
AAV mediated repression of Neat1 lncRNA combined with F8 gene augmentation mitigates pathological mediators of joint disease in haemophilia

Field: Medicine (Health Sciences)

Abstract Haemophilic arthropathy (HA), a common comorbidity in haemophilic patients leads to joint pain, deformity and reduced quality of life. We have recently demonstrated that a long non‐coding RNA, Neat1 as a primary regulator of matrix metalloproteinase (MMP) 3 and MMP13 activity, and its induction in the target joint has a deteriorating effect on articular cartilage. In the present study, we administered an Adeno‐associated virus (AAV) 5 vector carrying an short hairpin (sh)RNA to Neat1 via intra‐articular injection alone or in conjunction with systemic administration of a capsid‐modified AAV8 (K31Q) vector carrying F8 gene (F8‐BDD‐V3) to study its impact on HA. AAV8K31Q‐F8 vector administration at low dose, led to an increase in FVIII activity (16%–28%) in treated mice. We further observed a significant knockdown of Neat1 (~40 fold vs. untreated injured joint, p = 0.005) in joint tissue of treated mice and a downregulation of chondrodegenerative enzymes, MMP3, MMP13 and the inflammatory mediator‐ cPLA2, in mice receiving combination therapy. These data demonstrate that AAV mediated Neat1 knockdown in combination with F8 gene augmentation can potentially impact mediators of haemophilic joint disease.
Bolus Effective Dose of Ketamine for Preventing Withdrawal Movement on Injection of Rocuronium in Paediatric Patients

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The bolus effective dose of ketamine required to prevent withdrawal movement on injection of rocuronium was determined in 27 paediatric patients undergoing elective surgery. A predetermined dose of ketamine was given intravenously on arrival in the operating room and anaesthesia (2.5% thiopental, 5 mg/kg) was administered 1 min later. After loss of consciousness, 1% rocuronium at 0.6 mg/kg was injected over 5 s and the presence or absence of withdrawal movement recorded. The effective dose of ketamine was determined using a modified Dixon up-and-down method with a step size of 0.1 mg/kg, successful prevention of withdrawal movement being defined as no response or movement at the wrist only. The bolus effective dose of ketamine for preventing withdrawal movement after injection of rocuronium following thiopental anaesthesia in 50% of paediatric patients (ED 50 ) was 0.21 mg/kg according to the modified Dixon up-and-down method. Probit analysis indicated an ED 50 of 0.18 mg/kg and an ED 95 of 0.33 mg/kg. The latter was the most satisfactory dose in the clinical setting.
Managing the twenty-first century reference department : challenges and prospects

Field: Health Professions (Health Sciences)

* Introduction * Managing an Academic Reference Department * From Core Competencies to Desired Traits: Hiring a Head of Reference for the New Millennium * Managing the 21st Century Reference Department: Competencies * Training the New Head of Reference: Focusing on the Supervising Relationship as Technique * Collaborative Leadership: A Model for Reference Services * It Takes a Village to Manage the 21st Century Reference Department * The 21st Century Reference Department: Working to Provide Quality Service to Users * Leadership or Management: Expectations for Head of Reference Services * Index * Reference Notes Included
Molecular characterization of antibiotic producing bacteria Pseudomonas sp. BP-1 from Nagavali river basin of Srikakulam, Andhra Pradesh, India

Field: Immunology and Microbiology (Life Sciences)

The Pseudomonas sp. BP-1 strain (NCBI gene accession number HM359121) was isolated from Nagavali river basin of Srikakulam, Andhra Pradesh India. The strain is capable of inhibiting the growth of a wide variety of Gram +ve and Gram -ve bacteria. Partial 16S rRNA gene sequence of the isolate was sequenced and compared with the sequences of representative Pseudomonas sp. The 16S rRNA data supported the phylogenetic position of the strain within the genus Pseudomonas and was closely related to Pseudomonas sp. 19–28; (GenBank entry: EU167964) and Pseudomonas pseudoal-caligenes; RW31; (EU419918) with a sequence similarity of 99%.
Inhibition of Rho Kinase by Fasudil Ameliorates Cognition Impairment in APP/PS1 Transgenic Mice via Modulation of Gut Microbiota and Metabolites

Field: Neuroscience (Life Sciences)

Abstract Background: Fasudil, a Rho kinase inhibitor, exerts therapeutic effects in the mouse model of Alzheimer’s disease (AD), a chronic neurodegenerative disease with progressive loss of memory. However, the mechanisms remain unclear. In addition, the gut microbiota and its metabolites have been implicated in AD. Methods: Here, we examined the effect of fasudil on learning and memory using the Morris water-maze (MWM) test in APPswe/PSEN1dE9 transgenic (APP/PS1) mice (8 months old) treated (i.p.) with fasudil (25 mg/kg/day; ADF) or saline (ADNS) and in age- and gender-matched wild-type (WT) mice. Fecal metagenomics and metabolites were analyzed to identify novel biomarkers of AD and to elucidate the mechanisms whereby fasudil produced beneficial effects in AD mice. Results: Morris water maze test showed significant improvement of spatial memory in APP/PS1 mice treated with fasudil as compared to ADNS. The metagenomic analysis revealed the abundance of the dominant phyla in all the three groups, including Bacteroidetes (23.7% - 44%) and Firmicutes (6.4% - 26.6%), and the increased relative abundance ratio of Firmicutes / Bacteroidetes in ADNS (59.1%) compared to WT (31.7%). In contrast, the Firmicutes / Bacteroidetes ratio was decreased to the WT level in ADF (32.8%). Lefse analysis results of metagenomics showed s_Prevotella_sp_CAG873 as an ADF potential biomarker, while s_Helicobacter_typhlonius and s_Helicobacter_sp_MIT_03-1616 as ADNS potential biomarkers. Metabolite analysis revealed the increment of various metabolites, including glutamate, hypoxanthine, thymine, hexanoyl-CoA, and leukotriene, were relative to ADNS or ADF microbiota potential biomarkers and mainly involved in the metabolism of nucleotide, lipids, sugars, and the inflammatory pathway. Conclusions: Memory deficit in APP/PS1 mice was correlated with the gut microbiome and metabolite status. Fasudil reversed the abnormal gut microbiota and subsequently regulated the related metabolisms to normal in the AD mice. It is believed that fasudil can be a novel strategy for the treatment of AD via remodeling of the gut microbiota and metabolites. The novel results also provide valuable references for the use of gut microbiota and metabolites as diagnostic biomarkers and/or therapeutic targets in clinical studies of AD.
Thousand litre scale microcarrier culture of Vero cells for killed polio virus vaccine. Promising results.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Through the progress of scientific knowledge the Vero cell line was considered to be a suitable alternative cell substrate for the industrial production of Polio Virus. Using microcarrier culture, more than 10(12) cells could be obtained weekly for virus inoculation. The virus yield is around 60 D units/ml for type I; 20 D units/ml for type II, and 50 D units/ml for type III.
Differential expression of microRNA-21 in heterogeneous lung cancer cells promotes lung cancer metastasis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Objective
To investigate the relationship between the expression of microRNAs in lung cancer cells from different origins and the metastasis of lung cancer and its molecular mechanism.

Methods
K-ras overexpression and p53 deletion induce canceration of Beas2B and CC-H007. In vivo cells transplantation validated the induced tumor cells are able to grow secondary tumor. Scratch assays and Transwell migration assays were performed to study the migration ability of induced tumor cells. The mRNA expression level of miR-21, E-cadherin, N-cadherin and Vimentin was tested through quantitive real-time quantitative polymerase chain reaction (Real-time PCR).

Results
The transplanted assay showed that both of the two types of induced cells induced tumor in nude mice, the tumor weight is (0.86±0.06) g and (0.67±0.08) g respectively (t=59.251, 78.590, P 0.05).

Conclusion
Beas2B-origin tumor highly expressed miR-21 promoting lung cancer metastasis through induction of epithelial-to-mesenchymal transition, while CC-H007-tumor didn’t facilitate tumor metastasis with low miR-21 expression.

Key words:
Heterogeneous lung cancer cell; MicroRNA-21; Epithelial-to-mesenchymal transition; Metastasis
Radiative corrections for electron-proton elastic scattering taking into account high orders and hard-photon emission

Field: Physics and Astronomy (Physical Sciences)

We investigate the effect of high order radiative corrections in unpolarized\nelectron proton elastic scattering and compare with the calculations at lowest\norder, which are usually applied to experimental data. Particular attention is\ndevoted to the $\\epsilon$ dependence of radiative corrections, which is\ndirectly related to the electric proton form factor. We consider in particular\nthe effects of the interference terms for soft and hard photon emission. Both\nquadratic amplitude describing the collinear emission along the scattered\nelectron as well as the interference with the amplitudes of emission from the\ninitial electron and the emission from protons are important in leading and\nnext to leading approximation and they may compensate in particular kinematical\nconditions.\n
THE SYNTHESIS OF α,α′-DIMERCAPTO-SUCCINIC ACID

Field: Chemistry (Physical Sciences)

α,α'-Dimercapto-succinic acid was prepared by a simple synthesis involving the addition of thioacetic acid to the disodium salt of acetylene dicarboxylic acid (tetrahydrate), in the presence of dilute sulphuric acid (36.2%) and with pyridine as catalyst, followed by hydrolysis of the resulting addition compound. The disodium salt of acetylene dicarboxylic acid (tetrahydrate) was obtained from dibromosuccinic acid by treating the latter with an excess of concentrated sodium hydroxide solution.
One-Sided and Incomplete Investigation of the Circumstances of the Case in Adversarial Criminal Proceedings

Field: Social Sciences (Social Sciences)

Art. 389.15 of the Criminal Procedural Code of the Russian Federation contains a closed list of grounds for reversing or altering court rulings. The one-sidedness and incompleteness of the investigation of the factual circumstances of the criminal case is not indicated as one of such grounds. A one-sided or incomplete investigation of the factual circumstances of the case taken place in the course of criminal proceedings can influence the justness of the sentence. This conclusion follows from the analysis of the court practice formed after the 2013 reform. One of the goals of this reform was to obtain a “definitive judgment” upon completion of the appeal. Despite this, during the implementation of the reform, Article 389.15 of the Criminal Procedural Code of the Russian Federation, which establishes the list of grounds for reversing or altering court rulings, was not brought into line with the objectives of the reform. The law does not provide for such a ground as an incorrect investigation by the court of the factual circumstances of the criminal case, despite the numerous facts of revealing this violation by the courts of controlling authority.
Structural changes in the pollinated and unpollinated avocado stigma and style

Field: Agricultural and Biological Sciences (Life Sciences)

ABSTRACT Structural changes in the pollinated and unpollinated avocado (Persea americana Mill) stigma and style up to 42 h after first opening of the flower were investigated using light and electron microscopy. The pollen tubes grew in the stigma secretion and intercellular substance and initial contact occurred between the plasma membrane of the male and the cuticle and stigma secretion of the female. The pollen tube wall started to develop 15 min after pollination and increased in thickness up to 24 h after pollination. By 18 h after first opening of the flower, starch had disappeared and cell wall thickenings were present in both the pollinated and unpollinated stigma and style. The wall thickenings developed more slowly in the upollinated than in the pollinated tissue. They contained lipid and were bounded by callose. Degeneration of the cytoplasm of some of the papilla and transmitting tissue cells occurred only following the passage of the pollen tubes and may be of importance in tube nutrition. There was no degeneration in the unpollinated stigma and style and the cytoplasm did not start to lose clarity until 42 h after first opening of the flower.
Management of patients with chronic hepatitis and cirrhosis during the periooperative period of ophthalmic surgery

Field: Medicine (Health Sciences)

Aim . To study the frequency and structure of hepatitis and cirrhosis among ophthalmic surgery patients. Material and methods . Among 1706 ophthalmic surgery patients, 43 patients with chronic hepatitis and cirrhosis were selected. A clinical assessment of the etiology and severity of their condition was carried out and the possibility of performing ophthalmic surgery was determined. Results . The average age of the patients included in the study comprised 64.1 ± 9.7 years, with 72.1% of the patients belonging to the elderly age group. 88.4%, 9.3%, and 2.3% (one patient) of the patients suffered from viral hepatitis (B, C, chronic HBV and HCV coinfection), toxic hepatitis, and autoimmune hepatitis, respectively. Among hepatitis patients, HCV monoinfection prevailed (55.4%). The majority (97.7%) of patients demonstrated minimal disease activity. Although violations of the hemostatic system were detected in nine patients, signs of significant hypocoagulability were observed in three patients (6.9%). Following a 3-day course of intramuscular vitamin K injections 2 to 3 times per day, these three patients underwent successful ophthalmic surgery. Out of 97.7% of patients admitted to surgery, 39 people were operated in a planned manner and 3 people required medical preparation. In one patient with suspected acute viral hepatitis B, planned surgical treatment was postponed. Conclusions . The share of patients with hepatitis and cirrhosis in the general structure of ophthalmic surgery patients comprised 2.5%. Among them, viral hepatitis B and C prevailed (88.4%) with dominated HCV monoinfection (55.4%). The vast majority of patients (97.7%) showed minimal hepatitis activity; 6.9% had signs of significant hypocoagulability, thus requiring preoperative medical preparation.
Recognition of tRNAIle with a UAU anticodon by isoleucyl‐tRNA synthetase in lactic acid bacteria

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

In almost all eubacteria, the AUA codon is translated by tRNA Ile2 bearing lysidine at the wobble position. Lysidine is introduced by tRNA Ile lysidine synthetase (TilS) via post‐transcriptional modification of the cytidine of tRNA Ile2 (CAU). Lactobacillus casei and Lactobacillus plantarum have tilS homologues and tRNA Ile2 (CAU) genes. In addition, L. casei also has another tRNA Ile2 gene with an UAU anticodon. L. plantarum has a tRNA Ile (UAU)‐like RNA. Here, we demonstrate that L. casei tRNA Ile2 (UAU) is charged with isoleucine by L. casei isoleucyl‐tRNA synthetase (IleRS) but not by L. plantarum IleRS, even though the amino acid identity of these two enzymes is over 60%. It has been reported that, in Mycoplasma mobile , which has its tRNA Ile2 (UAU) but no tilS homologue, an Arg residue at position 865 of the IleRS is required for recognition of the UAU anticodon. This position is occupied by an Arg also in the IleRSs from both of the Lactobacillus species. Thus, other residues in L. casei , IleRS should also contribute to the recognition of tRNA Ile2 (UAU). We found that a chimeric L. casei IleRS in which the N‐terminal domain was replaced by the corresponding region of L. plantatarum IleRS has very low aminoacylation activity towards both tRNA Ile2 (UAU) and tRNA Ile1 (GAU). The A18G mutant had barely detectable aminoacylation activity towards either of the tRNAs Ile . However, a double point mutant of A18G and G19N aminoacylated tRNA Ile1 (GAU), but not tRNA Ile2 (UAU). Our results suggest that, for L. casei IleRS, Ala18 and Gly19 also play a critical role in recognition of tRNA Ile2 (UAU).
Ultra wide Band Antenna Design using CPW- Feed

Field: Engineering (Physical Sciences)

In this paper, the patch antenna with partial ground plane is used. The first task of this project is to design wide band antenna and then enhancing its bandwidth further to achieve UWB characteristics. Band broadening techniques in patch antenna is used to explore and analyze to achieve the target using different experiments. Similarly the matching of antenna has been improved with the help of partial ground plane. I have also explored the different parametric analysis at main radiator of antenna and the ground plane. As the target is to design antenna at lower cost so I have selected FR-4 substrate to make it possible. Simulation analysis to show that antenna is meeting the required band has been done in High Frequency Structure Simulator (HFSS).
Structured Input vs. Structured Output Task’s Effects on the Acquisition of the English Causative Forms: Discourse-Level. Structured Input vs. Structured Output Task’s Effects on the Acquisition of the English Causative Forms: Discourse-Level.

Field: Arts and Humanities (Social Sciences)

This research paper presents a quasi-experimental empirical study investigating the effects of structured input and structured output tasks on the acquisition of English causative forms. This research is framed on VanPatten’s (1996) input processing theory. The grammatical form chosen for this investigation is affected by a processing strategy called the First Noun Principle. There are three variables included that make this study significant. These variables are having participants that are young learners who speak Arabic as an L1 and using discourse-level instrumentation. These variables make this study significant because the studies that investigated the effectiveness of structured input practice with these variables are in the minority. The study’s main questions are: (i) What are the short-term effects of structured input and structured output on the acquisition of English causative forms as measured with discourse-level interpretation tasks? (ii) What are the short-term effects of structured input and structured output on the learners’ ability to acquire the English causative forms as measured with discourse-level production tasks? Participants were school-age learners (aged 12-13) from an Arabic background with Arabic as an L1 who studied English as a second language in Kuwait. A pre and post-test procedure was adopted in this study. Two instructional groups were created, which are: (i) structured input; (ii) structured output. Discourse-level tasks were used in the study to assess the effectiveness of the two instructional treatments. Results were analyzed using descriptive statistics and ANOVA. The main findings support the view that discourse-level structured input tasks are a useful pedagogical intervention in helping young L2 learners from an Arabic background with Arabic as an L1 to process, interpret and produce accurate English causative forms. The main findings have theoretical and pedagogical implications for language learning and teaching.
Medieval Christianity in Practice. Edited by Miri Rubin. Princeton Readings in Religions. Princeton, N.J.: Princeton University Press, 2007. xvi + 346 pp. $80.00 cloth; $22.95 paper.

Field: Arts and Humanities (Social Sciences)

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