jimnoneill/paper-to-field-training huggingface dataset:
Hands-Joined Learning as a Framework for Personalizing Project-Based Learning in a Middle Grades Classroom

Field: Social Sciences (Social Sciences)

This study investigates the hands-joined learning framework as an approach to personalize and provide instructional scaffolding within project-based learning. The authors include a case description of hands-joined learning in a middle school social studies classroom and critically examine middle school student feedback in relation to two aims: (a) personalizing learning, and (b) providing adequate scaffolding. Student feedback indicated that the hands-joined learning project was largely successful in these two areas. Learners appreciated having choice and control in what they learned and created in the project but also pointed to the need for greater opportunities to make decisions in how they learned. Some learners also wanted more peer interaction. These findings are used to propose practical implications as well as future research directions.
Factors associated with medication interruption among outpatients’ severe mental illness patients exposed to coronavirus disease 2019

Field: Medicine (Health Sciences)

Abstract Background. In clinical, many patients with severe mental illness (SMI) have a relapse and deterioration in their illness during COVID-19, with an experienced medication interruption. This study aimed to investigate factors affecting medicine interruption in patients with SMI during the COVID-19 pandemic. Methods. Between 3 September and 7 October 2020, 2,077 patients with SMI participated in an online survey regarding their medication interruption during the COVID-19 outbreak. The questionnaire comprised six parts: basic demographic information, COVID-19 exposure, state of disease, medication compliance pre-COVID-19, medication interruption during COVID-19, and the specific impact and needs. Results. 2,017 valid questionnaires were collected. Nearly 50% of patients with SMI have been affected to varying degrees in their lives and treatment. Among them, 74 patients stopped taking medicines for more than 14 days without a prescription. Binary logistic regression analysis showed that cohabitant exposure [OR = 26.629; 95% CI (3.293-215.323), p = 0.002], medication partial compliance and non-compliance pre-COVID-19 [OR = 11.109; 95% CI (6.093–20.251), p < 0.001; OR = 20.115; 95% CI (10.490-38.571), p < 0.001], and disease status [OR = 0.326; 95% CI (0.188–0.564), p < 0.001] were related to medication interruption. More than 50% of patients wanted help in taking medications, follow-up, and receiving more financial support and protective materials. Conclusions. Patients with a history of partial or non-medication compliance pre-COVID-19 and unstable disease state are more easily affect by epidemics and need extra attention should similar large-scale epidemics occur in future.
Morning versus evening induction of labour for improving outcomes

Field: Medicine (Health Sciences)

Taking into account women's preferences that favoured administration of prostaglandins in the morning, we conclude that caregivers should preferably consider administering prostaglandins in the morning.There is no strong evidence that induction of labour with intravenous oxytocin in the evening is more or less effective than induction in the morning. Consideration may be given to start induction of labour with oxytocin in the evening when indicated.
Predictable Broadcasting of Parallel Intents in Real-Time Android

Field: Computer Science (Physical Sciences)

Several approaches to extend the original Android implementation with real-time capabilities were presented in the last few years. Most of the research was limited to fundamental issues like real-time scheduling and non-blocking memory management. This paper demonstrates the weak predictability of Android's intra- and inter-process communication and presents a concept to improve its soft real-time capability. The proposed approach introduces a priority-based broadcast handling, instead of the original first in -- first out processing. Additionally, we reduce the size of responsible critical sections in order to improve the preemptibility and assure predictable delays for applications with real-time requirements. Our empirical evaluation highlights the improvements in comparison to the original Android implementation without loss of the performance for both global and local broadcast systems. Furthermore, the compatibility to already existing components and applications is preserved.
RESEARCH Open Access BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Background: Chronic Myeloid Leukaemia (CML) is caused by the BCR/ABL1 fusion gene. Both the presence and the levels of BCR/ABL1 expression seem to be critical for CML progression from chronic phase (CP) to blast crisis (BC). After the oncogenic translocation, the BCR/ABL1 gene is under the transcriptional control of BCR promoter but the molecular mechanisms involved in the regulation of oncogene expression are mostly unknown. Methods: A region of 1443bp of the functional BCR promoter was studied for transcription factor binding sites through in-silico analysis and Chromatin Immunoprecipitation experiments. BCR and BCR/ABL1 expression levels were analysed in CML cell lines after over-expression or silencing of MYC transcription factor. A luciferase reporter assay was used to confirm its activity on BCR promoter. Results: In the present study we demonstrate that MYC and its partner MAX bind to the BCR promoter, leading to up-regulation of BCR and BCR/ABL1 at both transcriptional and protein levels. Accordingly, silencing of MYC expression in various BCR/ABL1 positive cell lines causes significant downregulation of BCR and BCR/ABL1, which consequently leads to decreased proliferation and induction of cell death. Conclusions: Here we describe a regulatory pathway modulating BCR and BCR/ABL1 expression, showing that the BCR promoter is under the transcriptional control of the MYC/MAX heterodimer. Since MYC is frequently over-expressed in BC, this phenomenon could play a critical role in BCR/ABL1 up-regulation and blast aggressiveness acquired during CML evolution.
Results of the first two seasons of underwater surveys at Episkopi Bay and Akrotiri, Cyprus

Field: Arts and Humanities (Social Sciences)

During the summers of 2003 and 2004, a small team of graduate students\ninitiated an underwater archaeological survey off the coast of Cyprus as part of the\nUniversity of Cincinnati excavations at Episkopi-Bamboula. With the support of the\nInstitute of Nautical Archaeology (INA) at Texas A&M University and RPM Nautical\nFoundation, the project explored the seabed south and west of the Akrotiri Peninsula at\nEpiskopi Bay. The overall aim of this ongoing diachronic survey is to determine the\nextent and nature of maritime contacts at Episkopi-Bamboula and its Greco-Roman\nsuccessor, Kourion, from the Bronze Age through the Byzantine period.\nEfforts during these first two seasons concentrated on simple visual inspection of\nseveral promising areas near dangerous cliffs, offshore rocks and shallow reefs, as well\nas potential harbors and anchorages. The team recorded substantial pottery and anchor\nassemblages at Dreamer?s Bay, Cape Zevgari, and Avdimou Bay, including at least three\nshipwreck sites. Throughout the area, amphoras and anchors attest to varying levels of\nmaritime activity over the past three millennia.The underwater material record reveals a modest level of Classical trade,\nfollowed by a respectable increase during the Hellenistic era. While very little material\nthus far can be attributed to the earlier Imperial centuries, the greatest quantities in terms\nof both individual sherds and coherent assemblages speaks strongly to intense trade\nduring the Late Roman (Early Byzantine) period, from the fourth through the seventh\ncentury. Not surprisingly, this rapid floruit in maritime trade parallels the expansion of\nsettlement throughout the island, including its eventual collapse in the middle of the\nseventh century.
Videourodynamic analysis in men with lower urinary tract symptoms: Correlation between age and prostate size with lower urinary tract dysfunction

Field: Medicine (Health Sciences)

Objectives: Lower urinary tract symptoms (LUTS) are highly prevalent in aging men. In this study we examined the relationship between age, total prostate volume (TPV), and videourodynamic study findings. Methods: We retrospectively analyzed a total of 971 men ≥ 40 years of age referred to us for investigation of LUTS. We analyzed the distribution of the different videourodynamic study diagnoses in male LUTS by correlating their age and prostate size. Results: The most common diagnosis in the bladder outlet obstruction (BOO) group differed significantly by age and poor relaxation of the external sphincter (PRES) in those aged < 50 years; bladder neck dysfunction in those aged 50–69 years, and benign prostatic obstruction in those ≥ 60 years. Detrusor overactivity was the most common diagnosis in all ages in the bladder dysfunction group, and the cases of hyperactivity with impaired contractility (DHIC) increased with age. In patients < 50 years of age, PRES was the most common diagnosis in the BOO group in both those with small prostates (total prostate volume ≤ 40 mL) and large prostates (total prostate volume > 40 mL). In patients aged 50–69 years, the most common diagnosis in those with BOO and a small prostate was bladder neck dysfunction, and that in those with BOO and a large prostate was benign prostatic obstruction. Similar results were observed in patients aged ≥ 70 years. In all age groups, the majority of patients with detrusor overactivity, hypersensitive bladder, detrusor underactivity, and DHIC had a small prostate. Conclusion: In male LUTS, the diagnoses in the BOO group differed by age and prostate volume. In young patients with BOO, the leading diagnosis was PRES, and the contribution of prostate volume to BOO increased with age. As age increased, the bladder function became more complex with an increased percentage of patients with DHIC. Both bladder outlet and bladder functions were affected by age.
LHD Langmuir #909927.1

Field: Physics and Astronomy (Physical Sciences)

Langmuir probes on divertor plates to investigate divertor plasma parameters and fluctuation characteristics of ion flux near the divertor plates. Total 400 Langmuir probes embedded on 20 divertor plates on each of which 20 electrodes are aligned every 6 mm. Sweeping and sampling frequency is normally 250 kHz.
Kinetics of uranium leaching process using sulfuric acid for Wadi Nasib ore, South western Sinai, Egypt

Field: Chemical Engineering (Physical Sciences)

The leaching of uranium from Wadi Nasib ore using sulfuric acid solution has been studied. The effect of different parameters such as leaching time, sulfuric acid concentration, solid/liquid ratio, leaching temperature and mechanical stirring speed were investigated in order to optimize various process parameters for maximizing the recovery of uranium. Uranium dissolution efficiency of 98.5% was obtained for Wadi Nasib ore after 4 hours contact time leaching using 200 g L-1 H2SO4 and solid/liquid ratio 1/4 at leaching temperature 80°C and 400 rpm mechanical stirring speed without any oxidant addition. The kinetic data showed that the leaching process can be described by a shrinking-core model with apparent activation energy equals to 16.2 kJ/mol. The low activation energy supported the findings that the Wadi Nasib leaching rate is controlled by diffusion-controlled process.
Metal ion mediated hydrolysis of4-nitrophenylphosphate in microemulsion media: catalytic versus stoichiometric effects

Field: Chemistry (Physical Sciences)

The hydrolysis of 4-Nitrophenylphosphate (NPP) as model substrate in the presence of several cobalt (III) amine [N4Co(OH)(H2O)] and copper bipyridyl [Cu(bpy)(H2O)2] complexes in oil in water microemulsion media was investigated. The reaction was monitored by measuring the absorbance of the nitrophenolate ion produced in the reaction aliquots with time under the experimental conditions. The order of effectiveness of the microemulsion systems towards the hydrolysis of NPP in the presence of these metal ions were found to be cationic > anionic > aqueous at neutral pH. The results of the present investigation exhibits stoichiometric turnovers for the 1:1, 2:1 and 3:1 cobalt to NPP ratio and catalytic turnovers for the [Cu(bpy) to NPP ratio of 1:20. Catalysis in the microemulsion mediated reaction solutions was evident even in low concentrations of the metal ions in 1:2000 metal to NPP ratio. An explanation for the enhanced catalytic activity of the [Cu(bpy)(OH)(H2O)] complex for the hydrolysis of NPP is afforded and the application of the above model systems for possible environmental decontamination of toxic organophosphates is anticipated.
Supporting Periodic Authorizations and Temporal Reasoning in Database Access Control

Field: Computer Science (Physical Sciences)

Several formal models for database access control have been proposed. However, little attention has been paid to temporal issues like authorizations with limited validity or obtained by deductive reasoning with temporal constraints. We present an access control model in which authorizations contain periodic temporal intervals of validity. An authorization is automatically granted in the time intervals specified by a periodic expression and revoked when such intervals expire. Deductive temporal rules with periodicity and order constraints are provided to derive new authorizations based on the presence or absence of other authorizations in specific periods of time. We prove the uniqueness of the set of implicit authorizations derivable at a given instant from the explicit ones, and we propose an algorithm to compute the global set of valid authorizations. The resulting model provides a high degree of flexibility and allows to express several protection requirements that cannot be express...
Distinct populations of dendritic cells are present

Field: Immunology and Microbiology (Life Sciences)

Despite the fact that the Peyer&apos;s patch (PP) is the primary site for antigen uptake in the intestine, the cellular basis of antigen handling after transport into the PP is poorly understood. We performed immunohistology of routine PPs using the dendritic cell (DC)-reactive monoclonal antibodies N418, NLDC-145, M342, and 2A1, as well as antibodies to other T cell, B cell, and macrophage markers. N418 § 2A1 +, NLDC-145-, M342- cells form a dense layer of cells in the subepithelial dome (SED), just beneath the follicle epithelium, and are scattered throughout the follicle, sparing the germinal center. In contrast, N418 +, 2A1 +, NLDC-145 +, and M342 § DCs are present in the interfollicular T cell regions (IF[L). CD3 + and CD4 § but no CD8 + T cells were present in the SED and the follicle, including the germinal center, while CD3 +, CD4 +, and CDS- T ceils were present in the IF[L. B cells and macrophages were poorly represented in the SED as no B220 + cells, only few Mac-11 ~ cells, and no F4/80 + cells were present at this site. In contrast, Mac-1 h ~ cells were found in the IF[L and lamina propria of intestinal villi, while F4/80 § cells were found only in the latter. In further phenotypic studies, we analyzed surface molecules of PP and spleen DCs by flow cytometry and found that these ceils had similar fluorescence profiles when stained with N418, NLDC-145, and 33D1 DC-reactive
Fact extraction from bash in support of script migration

Field: Computer Science (Physical Sciences)

Owl Computing Technologies provides software and hardware that facilitates secure unidirectional data transfer across the Internet. Bash scripts are used to facilitate customer installation of Owl's client/server software, and to provide high level management, control, and monitoring of client/server interfaces. With the evolution of more robust scripting languages, Owl now wishes to convert their bash scripts to other scripting languages. As part of this conversion exercise the configuration and customization of their bash scripts will no longer involve direct end user modifications of the script logic. It will instead be achieved through appropriate modification of a supporting XML configuration file, which is read by each script. This avoids the risk that end users erroneously change scripts, and makes legitimate end user customization of their scripts simpler, more obvious, and easier to discern. An open source fact extractor was implemented that determines the dynamic usage made of every variable within an arbitrary bash script. This tool reports errors in a script and generates an XML configuration file that describes variable usage. Those variables whose value may not be assigned by an end user are manually removed from this XML configuration file. A second program reads this configuration file, generates the appropriate bash variable assignment statements, and these are then applied within bash by using the bash eval command. Collectively this provides a simple mechanism for altering arbitrary bash scripts so that they use an external XML configuration file, as a first step in the larger exercise of migrating bash scripts to other scripting languages.
Peer Attachment and Child’s Social Competence

Field: Psychology (Social Sciences)

Peer attachment has a big influence on children's social competence; thus, it needs to be improved, especially their attachment to the surrounding environment.To achieve social competencies as expected, it is important to develop social abilities in children.The role of peers is a supporting factor for children in terms of the development of social abilities.Stickiness greatly influences success in developing social competence.The purpose of this journal analysis is to review the effect of peer attachment on children's emotional competence.The study was conducted on children aged 7-18 years.The data analysis uses linear regression.The analysis shows that peer attachment can affect a child's social competence.The higher the secure attachment, the higher the child's social competence in the future.Conversely, the lower the attachment to safety, the lower the social competence of children in the future.
Ductal carcinoma in situ: Current diagnostic and therapeutic approaches

Field: Medicine (Health Sciences)

Advancements in breast cancer screening have significantly increased the incidence of ductal carcinoma in situ (DCIS) diagnoses. Despite its favorable prognosis, DCIS poses a clinical challenge due to its biological heterogeneity and potential progression to invasive ductal carcinoma (IDC). Mammography remains the primary diagnostic modality, with microcalcifications as the most common radiological finding. Management is primarily surgical, involving either breast-conserving surgery (BCS) or mastectomy, depending on the extent of the lesion. In patients undergoing BCS, adjuvant radiotherapy is recommended to reduce the risk of local recurrence, while hormonal therapy (tamoxifen or aromatase inhibitors) is indicated for hormone receptor-positive tumors. Axillary lymph node dissection is not routinely performed but may be considered in cases with suspected microinvasion. Recently, active surveillance has emerged as a potential alternative for selected low-risk patients. Ongoing research is focused on the identification of prognostic factors to enable more precise risk stratification. This review provides an overview of current multidisciplinary approaches to the diagnosis and treatment of DCIS, based on the latest scientific evidence.
Revisions to Title IX guidance translate to procedural changes

Field: Social Sciences (Social Sciences)

As of Sept. 22, 2017, the Office for Civil Rights officially withdrew the policy statements and guidance reflected in its April 4, 2011, “Dear Colleague Letter” on sexual violence and its April 29, 2014, Q&A on Title IX and sexual violence. In tandem with its announcement, OCR issued a new Q&A on campus sexual misconduct. The announcement came several weeks after the U.S. secretary of education revealed the Department of Education would undertake a formal rulemaking process on regulations to address campus sexual misconduct under Title IX.
The Murine Gammaherpesvirus 68 v-Cyclin Gene Is an Oncogene That Promotes Cell Cycle Progression in Primary Lymphocytes

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ABSTRACT Several gammaherpesviruses contain open reading frames encoding proteins homologous to mammalian D-type cyclins. In this study, we analyzed the expression and function of the murine gammaherpesvirus 68 (γHV68) viral cyclin (v-cyclin). The γHV68 v-cyclin gene was expressed in lytically infected fibroblasts as a leaky-late mRNA of approximately 0.9 kb encoding a protein of approximately 25 kDa. To evaluate the effect of the γHV68 v-cyclin on cell cycle progression in primary lymphocytes and to determine if the γHV68 v-cyclin gene is an oncogene, we generated transgenic mice by using the lck proximal promoter to express the γHV68 v-cyclin in early T cells. Expression of the γHV68 v-cyclin significantly increased the number of thymocytes in cell culture, as determined by measuring both DNA content and incorporation of 5-bromo-2-deoxyuridine following in vivo pulse-labeling. Expression of the γHV68 v-cyclin interfered with normal thymocyte maturation, as shown by increased numbers of CD4 + CD8 + double-positive thymocytes and decreased numbers of CD4 + or CD8 + single-positive and T-cell-receptor-bright thymocytes and splenocytes in transgenic mice. Despite increased numbers of cycling thymocytes, γHV68–v-cyclin–transgenic mice did not have proportionately increased thymocyte numbers, and staining by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling demonstrated increased apoptosis in the thymi of v-cyclin-transgenic mice. Fifteen of 38 γHV68–v-cyclin–transgenic mice developed high-grade lymphoblastic lymphoma between 3 and 12 months of age. We conclude that (i) the γHV68 v-cyclin is expressed as a leaky-late gene in lytically infected cells, (ii) expression of the γHV68 v-cyclin in thymocytes promotes cell cycle progression and inhibits normal T-cell differentiation, and (iii) the γHV68 v-cyclin gene is an oncogene.
Experimental Evaluation of a Forward-Looking Sonar-Based System for Acoustic Odometry

Field: Engineering (Physical Sciences)

Autonomous Underwater Vehicles (AUVs) need safe and reliable navigation systems in order to perform the required tasks. Unfortunately, it is well known that the Global Positioning System (GPS) cannot be exploited during underwater missions. As a consequence, the real-time position of the AUV is usually obtained by means of recursive navigation filters such as Kalman Filter (KF), Extended Kalman Filter (EKF), Unscented Kalman Filter (UKF) or dead reckoning techniques where direct speed measurements are usually provided by specialized underwater sensors such as the Doppler Velocity Log (DVL). The final aim of this work is to propose an underwater navigation solution where the AUV is able to safely navigate without the need of a DVL. In particular, linear speed estimations are obtained from a Forward-Looking SONAR (FLS) or, in its absence, exploiting a simple dynamic model. The proposed solution is validated making use of data obtained during test at sea performed in La Spezia (Italy).