MP28-12 IMPACT OF LYMPHOVASCULAR INVASION ON LYMPH NODE METASTASIS FOR T3 PATIENTS UNDERGOING RADICAL PROSTATECTOMY IN CONSIDERATION OF RESECTION MARGIN STATUS

Field: Medicine (Health Sciences)

You have accessJournal of UrologyProstate Cancer: Markers I1 Apr 2017MP28-12 IMPACT OF LYMPHOVASCULAR INVASION ON LYMPH NODE METASTASIS FOR T3 PATIENTS UNDERGOING RADICAL PROSTATECTOMY IN CONSIDERATION OF RESECTION MARGIN STATUS Yong Jin Kang, Won Sik Jang, Myung Soo Kim, Won Sik Jung, Cheol Yong Yoon, In Rae Cho, and Young Deuk Choi Yong Jin KangYong Jin Kang More articles by this author , Won Sik JangWon Sik Jang More articles by this author , Myung Soo KimMyung Soo Kim More articles by this author , Won Sik JungWon Sik Jung More articles by this author , Cheol Yong YoonCheol Yong Yoon More articles by this author , In Rae ChoIn Rae Cho More articles by this author , and Young Deuk ChoiYoung Deuk Choi More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.825AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To assess an association between the increased risk of biochemical recurrence and lymphovascular invasion in T3 margin positive or negative patients and its association with lymph node metastasis. METHODS 1634 patients who underwent radical prostatectomy from 2005 to 2014 were selected. Patients with bone or distant organ metastasis at the time of operation were excluded. Survival analysis was performed to assess biochemical recurrence, bone metastasis and mortality risks by Kaplan-Meier analysis and multivariate Cox proportional hazard regression. Odds of lymph node metastasis were evaluated by Logistic regression. RESULTS LVI was detected in 118 (7.4%) patients. The median follow-up duration was 33.1 months. In the Kaplan-Meier analysis, lymphovascular invasion was associated with significantly shorter biochemical recurrence free survival (39.3 vs. 82.5 months, p<0.001), bone metastasis-free survival (134.4 vs. 156.7 months, p=0.001) and cancer specific survival (122.7 vs. 152.6 months, p=0.034). When stratified by T stage and resection margin status, lymphovascular invasion resulted in significantly shorter biochemical recurrence-free duration in T3 patients with and without positive surgical margin (p=0.008, 0.005, respectively). In the multivariate Cox regression model lymphovascular invasion resulted in 1.4-fold risk increase (95% CI 1.05-1.75, p=0.031).Lymphovascular invasion was revealed to be strongly associated with lymph node metastasis in the multivariate Logistic regression (OR 4.26, 95% CI 2.07-8.79, p<0.001). CONCLUSIONS Lymphovascular invasion increased the risk of early recurrence in T3 patients regardless of margin status, by accelerating the metastasis. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e342-e343 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Yong Jin Kang More articles by this author Won Sik Jang More articles by this author Myung Soo Kim More articles by this author Won Sik Jung More articles by this author Cheol Yong Yoon More articles by this author In Rae Cho More articles by this author Young Deuk Choi More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...