jimnoneill/paper-to-field-training huggingface dataset:
Transforming an Autism Pediatric Research Network into a Learning Health System: Lessons Learned

Field: Health Professions (Health Sciences)

Introduction: The Autism Speaks Autism Treatment Network that serves as the Autism Intervention and Research Network on Physical Health (ATN/AIR-P) has a mission to improve the health and well-being of children with Autism Spectrum Disorder and determine the best practices that lead to improved outcomes and expedite the translation of findings to practice. To better achieve this mission, the ATN/AIR-P is engaging in a design process to transition to a Learning Network (LN), the Autism Learning Health Network. The purpose of this paper is to: (1) make the medical and patient communities aware of an Autism LN that is based on the Institute of Medicine’s definition of a Learning Health System; (2) describe how and why the ATN/AIR-P transformed to an LN; and (3) share lessons learned that might inform the transition of future existing networks surrounding other conditions. Methods: Design methods included: an in-person design session with various stakeholders, the development of a Key Driver Diagram and redesign of organizational processes, network governance, and data collection and analytics. Results: We realized many benefits in making the transition to an LN along with many lessons that can inform the design and implementation of the LN model when transforming existing networks to learning health systems. Conclusions: Transitioning a well-established research network requires a complex redesign of existing processes, data infrastructure, and cultural shifts compared with developing a new LN. We identified factors that may inform the transition of future established networks to expedite the process.
Acute and Sub-Acute Oral Toxicity Evaluation of Astragalus hamosus Seedpod Ethanolic Extract in Wistar Rats

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background: Oral consumption of Astragalus hamosus L. (AH) seedpod has been widely prescribed in traditional medicine system. However, its toxicity evaluation has never been investigated. Hence, the current study was performed to evaluate the toxicological profile of AH seedpod in acute and subacute assessments based on the OECD-guidelines 425 and 407 in male and female Wistar rats. Methods: In the acute study, ethanolic extract of AH at a single dose of 2000 mg/kg was orally administrated to six female rats. In the subacute assay, AH at the three different oral doses (75, 150 and 300 mg/kg) were administrated to both male and female rats for 28 consecutive days. Results: No death or behavioural changes were observed in the treated animals. In subacute test, in both sexes, no changes in organ weights observed. Biochemically, compared to the control, AH at the dose of 300 mg/kg slightly increased (p<0.05) uric acid and creatinine and declined total cholesterol levels in both male and female rats. However, there is no statistically difference in other parameters such as albumin, triglyceride, blood urea, aspartate aminotransferase and alanine aminotransferase between AH treated groups and untreated controls. Hematologic parameters showed that AH at the maximum dose decreased red blood cells count only in male rats. Histopathological evaluation of liver and kidney exhibited no noticeable alterations in AH treated animals. Conclusion: It could be concluded that high excessive and long term consumption of AH may lead to renal dysfunction and deficiency in hematopoietic system.
Supplementation of different selenium sources during early lactation of native goats and their effects on nutrient digestibility, nitrogen and energy status

Field: Agricultural and Biological Sciences (Life Sciences)

The aim of this study was to compare the effects of two Se sources on the early lactation of native goats, on nutrient digestibility, as well as nitrogen and energy status of Iranian native goats. Twenty-one native goats aged, approximately 41 ± 9 months and having body weights of 46 ± 8 kg were selected for the experiment. The goats were randomly divided into three groups with an equal number of goats. One group was supplemented with Selemax 2000® as the organic selenium (OS), the second group received diluted sodium selenite as the inorganic selenium, while the third group received no supplementation and served as the control group (C). The results of this research showed that the selenium supplement did not have a significant effect on nutrient digestibility (apart from crude fat) (P > .05) but, the dry matter, organic matter and crude protein intake significantly increased. However, faecal N, urinary N, total N production and energy status were affected by the treatments (P < .05). It can be concluded that OS seems to be a better choice, considering the nitrogen and energy available for metabolism and its partition between milk production and deposit/mobilization within the body.
Schwann Cells in the Tumor Microenvironment: Need More Attention

Field: Medicine (Health Sciences)

The tumor microenvironment (TME), which is composed of various cell components and signaling molecules, plays an important role in the occurrence and progression of tumors and has become the central issue of current cancer research. In recent years, as a part of the TME, the peripheral nervous system (PNS) has attracted increasing attention. Moreover, emerging evidence shows that Schwann cells (SCs), which are the most important glial cells in the PNS, are not simply spectators in the TME. In this review article, we focused on the up-to-date research progress on SCs in the TME and introduced our point of view. In detail, we described that under two main tumor-nerve interaction patterns, perineural invasion (PNI) and tumor innervation, SCs were reprogrammed and acted as important participants. We also investigated the newest mechanisms between the interactions of SCs and tumor cells. In addition, SCs can have profound impacts on other cellular components in the TME, such as immune cells and cancer-associated fibroblasts (CAFs), involving immune regulation, tumor-related pain, and nerve remodeling. Overall, these innovative statements can expand the scope of the TME, help fully understand the significant role of SCs in the tumor-nerve-immune axis, and propose enlightenments to innovate antitumor therapeutic methods and future research.
IMPLEMENTASI UPAH MINIMUM KABUPATEN BOYOLALI TERHADAP PEKERJA/BURUH PADA USAHA KONVEKSI BERDASARKAN UNDANG-UNDANG RI NOMOR 13 TAHUN 2003 TENTANG KETENAGAKERJAAN

Field: Social Sciences (Social Sciences)

<p>Abstract<br />Wages are the rights of laborers/workers received in return from the employer or employers for a job and/or services that have been or will be implemented. Minimum standards are used by employers to provide wages to laborers/workers are minimum wage. This article aim to know Implementation of Minimum Wages Boyolali Regency to laborers/workers on the Convection Based on the Law Republic of Indonesia Number 13 Year 2003 about Employement. This research is a socilogical/empirical legal that is eksplanatif (explain). Research locations are some convections in Teras and sorounding in Boyolali Regancy, and The office for cooperatives and labor Boyolali Regancy. Based on this research obtained the results of that Implementation of Minimum Wages Boyolali Regency to laborers/workers on the Convection Based on the Law Republic of Indonesia Number 13 Year 2003 about Employement not run optimally.<br />Key words: Minimum Wage; Laborers/Workers; Employement Inspection, Welfare</p><p>Abstrak<br />Upah merupakan hak pekerja/buruh yang diterima sebagai imbalan dari pengusaha atau pemberi kerja atas suatu pekerjaan dan/atau jasa yang telah atau akan dilaksanakan. Standar minimum <br />yang digunakan pengusaha untuk memberikan upah kepada pekerja/buruh adalah upah minimum. Artikel ini bertujuan untuk mengetahui implementasi Upah Minimum Kabupaten Boyolali terhadap pekerja/buruh pada usaha konveksi berdasarkan Undang-Undang RI No. 13 Tahun 2003 tentang Ketenagakerjaan. Penelitian ini adalah penelitian hukum sosiologis/penelitiam hukum empiris yang bersifat eksplanatif (menerangkan). Lokasi penelitian adalah beberapa usaha konveksi di Teras dan sekitarnya di Kabupaten Boyolali, dan Dinas Koperasi dan Tenaga Kerja Kabupaten Boyolali. Berdasarkan penelitian ini diperoleh hasil bahwa Implementasi Upah Minimum Kabupaten Boyolali Terhadap Pekerja/Buruh Pada Usaha Konveksi Berdasarkan Undang-Undang RI Nomor 13 Tahun 2003 Tentang Ketenagakerjaan belum berjalan secara optimal.<br />Kata kunci: Upah Minimum; Pekerja/Buruh; Pengawasan Ketenagakerjaan, Kesejahteraan</p>
Proton Power Upgrade: Conceptual Design Report

Field: Physics and Astronomy (Physical Sciences)

Oak Ridge National Laboratory (ORNL) operates and develops world-leading neutron scattering user facilities as centers of scientific excellence, attracting the best researchers from universities, industry, and national laboratories to advance scientific discovery and solve challenging technology problems that are best addressed using neutrons. As the first megawatt-class pulsed neutron source, the ORNL Spallation Neutron Source (SNS) generates the world’s most intense, highest-peak-brightness neutron beams, providing US researchers with capabilities that are unique in the world.
Emergency Preparedness in Hospitals: Managing Chemical, Biological, and Radiological Hazards in Raipur, Chhattisgarh

Field: Health Professions (Health Sciences)

Abstract This paper investigates the preparedness of hospitals in Raipur, Chhattisgarh, for managing chemical, biological, and radiological (CBR) emergencies. These hazards pose significant risks to public health, and the ability of hospitals to handle such emergencies is vital. The research evaluates emergency response systems in AIIMS Raipur, MMI Narayana, and Balaji Hospital using a mixed-method approach—surveys, interviews, and observational analysis. Findings show significant gaps in training, infrastructure, coordination, and SOP implementation. The study recommends strategies to strengthen hospital resilience and establish city-wide preparedness networks.
PECUNIARY SUPPORT AND HEALTHINESS OF OLDER PERSONS OF RAWALPINDI

Field: Social Sciences (Social Sciences)

Paper aimed at analyzing the impact and relationship of pecuniary support on the health of the older population following one’s gender. A sample of 384 respondents were selected and interviewed from Rawalpindi city. An interview schedule was developed as a tool, and pre- testing was employed to enhance tool quality. Data were analyzed using SPSS and the findings revealed that there exists a relationship between financial support and the health status of old people. Data shows, 69.53% of respondents were financially supported by their children while 40.89% of them were seeking financial support from either governmental or private institutions. The calculated p-value was 0.001. Relationship prevails between both variables that affect the older population of males and females. Meanwhile, the research study indicated the vulnerable situation of older people in society and suggested some measures to improve their health that includes: means of providing financial support or employment opportunities for the older population.
The work of John Hughlings Jackson: Part 1 by JM López Piñero

Field: Neuroscience (Life Sciences)

After returning to Spain from a research period in London on a Wellcome Trust scholarship, José Maria López Piñero 1 published in 1973 a short book entitled John Hughlings Jackson (1835—1911), Evolucionismo y Neurología (Madrid, Editorial Moneda). Written from the perspective of the classical German medical historiography that the author had imbibed from Werner Leibbrand and Annemarie Wettley, this work truly added to Jacksonian scholarship. Neither hagiographic nor nitpicking, it offered a sober assessment of the contribution of the great Yorkshireman and it was soon to become a minor classic among connoisseurs. Although important additions to Jacksonian scholarship have appeared since 1973, 2 López Piñero’s book has retained its relevance. It will be published in History of Psychiatry in two parts. 3
Additional file 2 of Network hub-node prioritization of gene regulation with intra-network association

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Additional file 2: Figure S1. Boxplots of local weights (left column) and topology weights (right column). Here the thresholds are set at conservative values: 0.05 for αL, 1 for αS, and no limit for D so that all nodes are included. Figure S2: Analyses of the mTor pathway for the breast cancer study. Figure S3: Analyses of the estrogen pathway for the breast cancer study. Figure S4: Analyses of the JAK-STAT pathway for the breast cancer study. Figure S5: The hub ranking rate of NetworkHub corresponding to different threshold values before and after the pathway association test, under four scenarios. A: Before. B: After.
Test–Retest Reliability, Agreement and Criterion Validity of Three Questionnaires for the Assessment of Physical Activity and Sedentary Time in Patients with Myocardial Infarction

Field: Health Professions (Health Sciences)

Regular physical activity (PA) and limited sedentary time (SED) are highly recommended in international guidelines for patients after a myocardial infarction (MI). Data on PA and SED are often self-reported in clinical practice and, hence, reliable and valid questionnaires are crucial. This study aimed to assess the test–retest reliability, criterion validity and agreement of two PA and one SED questionnaire commonly used in clinical practice, developed by the Swedish National Board of Health and Welfare (BHW) and the Swedish national quality register SWEDEHEART. Data from 57 patients (mean age 66 ± 9.2 years, 42 males) was included in this multi-centre study. The patients answered three questionnaires on PA and SED at seven-day intervals and wore an accelerometer for seven days. Test–retest reliability, criterion validity and agreement were assessed using Spearman’s rho and linearly weighted kappa. Test–retest reliability was moderate for three of the six-sub questions (k = 0.43–0.54) within the PA questionnaires. For criterion validity, the correlation was fair within three of the six sub-questions (r = 0.41–0.50) within the PA questionnaires. The SED questionnaire had low agreement (k = 0.12) and criterion validity (r = 0.30). The studied questionnaires for PA could be used in clinical practice as a screening tool and/or to evaluate the level of PA in patients with an MI. Future research is recommended to develop and/or evaluate SED questionnaires in patients with an MI.
The Identification and Distribution of some Cyperaceae and Gramineae, Chiefly from Australia.

Field: Agricultural and Biological Sciences (Life Sciences)

The identification, nomenclature and distribution of some Cyperaceae and Gramineae are discussed.Six species are new records for Australia, one for both Queensland and South Australia, and two for Queensland, while six new species are described.Many sedges and grasses found in Australia are also found over a wide area beyond Australia.The identification of these " wides " is often a serious difficulty which can only be solved by the study of types of all the names of allied species, many of which are not readily available.The loan of several such types from the herbaria at Lund (ld), Paris (p) and Copenhagen (c) has been made to me through the kindness of Dr. A. Hassler, Prof. H. Humbert and Dr. O. Hagerup respectively, and I wish to express my gratitude to them for their assistance.Miss M. B. Tindale
Response Prediction for Linear and Nonlinear Structures Based on Data-Driven Deep Learning

Field: Engineering (Physical Sciences)

Dynamic analysis of structures is very important for structural design and health monitoring. Conventional numerical or experimental methods often suffer from the great challenges of analyzing the responses of linear and nonlinear structures, such as high cost, poor accuracy, and low efficiency. In this study, the recurrent neural network (RNN) and long short-term memory (LSTM) models were used to predict the responses of structures with or without nonlinear components. The time series k-means (TSkmeans) algorithm was used to divide label data into different clusters to enhance the generalization of the models. The models were trained with different cluster acceleration records and the corresponding structural responses obtained by numerical methods, and then predicted the responses of nonlinear and linear structures under different seismic waves. The results showed that the two deep learning models had a good ability to predict the time history response of a linear system. The RNN and LSTM models could roughly predict the response trend of nonlinear structures, but the RNN model could not reproduce the response details of nonlinear structures (high-frequency characteristics and peak values).
Odd-parity quadrupole order and induced nonreciprocal transport in the kagome metal CsTi$_3$Bi$_5$ driven by quantum interference

Field: Physics and Astronomy (Physical Sciences)

Kagome metals present a fascinating platform of quantum phases thanks to the interplay between the geometric frustration and strong electron correlation. Here, we propose the emergence of the electric odd-parity bond order (BO) that originates from the intra-unit-cell odd-parity configuration in recently discovered kagome metal CsTi$_3$Bi$_5$. The predicted E1u BO is induced by the beyond-mean-field mechanism, that is, the quantum interference among different sublattice spin fluctuations. Importantly, the accompanied nematic deformation of the Fermi surface is just ~1% while the intensity of the quasiparticle interference signal exhibits drastic nematic anisotropy, consistent with the scanning tunneling microscope measurements in CsTi$_3$Bi$_5$. The present odd-parity BO triggers interesting phenomena, such as the non-linear Hall effect and emergent electromagnetism.
Characterization of tHermotropic State Changes in Myosin Subfragment-1 and Heavy Meromyosin by UV Difference Spectroscopy

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Thermotropic structural transitions in rabbit skeletal muscle heavy meromyosin and subfragment-1 (S-1) have been quantitatively investigated by using nucleotide-induced UV difference spectroscopy. The magnitude of the adenylyl 5'-imidophosphate (AMP-PNP)-induced difference spectrum is temperature-dependent for both S-1 and heavy meromyosin (HMM). The transition observed here appears to be the same transition observed by 31P NMR of bound AMP-PNP (Shriver, J., and Sykes, B. D. (1981) Biochemistry 20, 2004-2012). The ADP-induced spectrum is temperature-independent, which differs from the 31P NMR data, indicating that the chromophore contributing to the difference spectrum resides in a domain distinct from the active site, at least when ADP is bound. Although the magnitudes of the AMP-PNP-induced spectra are equal in magnitude for S-1 and HMM on a globular head basis, the temperature dependence of the AMP-PNP induced difference spectrum for S-1 differs significantly from that of HMM. The van't Hoff enthalpy for the apparent two-state transition in S-1 is half that observed with HMM: 19 (+/- 7.5) kcal/mol for S-1 and 35 (+/- 5) kcal/mol for HMM. This indicates an additional cooperative interaction in HMM which is not present in S-1. Modification of SH1 results in the loss of the temperature dependence of the AMP-PNP-induced difference spectrum, and the resulting difference spectra appear identical to those induced by ADP.
Does A Major Earthquake Change Attitudes and Well-Being Judgments? A Natural Experiment

Field: Psychology (Social Sciences)

Does a major natural disaster change life satisfaction? This study is a rare natural experiment, in which roughly half of the respondents completed the survey before and the other half completed it after the Great East Japan Earthquake of March 11, 2011. A series of regression discontinuity design analyses showed that those who completed the survey after the earthquake reported being less satisfied with their lives than those who happened to complete the survey before the earthquake. There were no discontinuity on demographic variables and other consumer attitudes. The main findings remained virtually unchanged when we controlled for Big Five personality traits and demographic variables. Together, the current findings suggest that the experience of a major natural disaster changes their life satisfaction at least in the short run.
Buy4Me: A Delivery System via Mobility Prediction Based on Mobile Crowd Sensing

Field: Computer Science (Physical Sciences)

With the prevalent development of rich sensor-equipped smart phones, mobile crowd sensing becomes a new sensing paradigm beyond traditional sensor networks. In this paper we propose and develop Buy4Me, a delivery system based on mobile crowd sensing. It can be used in different scales, such as a university campus or a city, to make shopping and delivering more convenient. When you need something not near, Buy4Me can recommend a friend to bring it for you without extra work. Users' mobility histories are analyzed to predict where a user will visit, and whether she will encounter with the others. Then Buy4Me ranks friends by the probability of whether they completing the delivering task, and returns top-k friends. We evaluate the method with the dataset contributed by Microsoft Research Asia, and find that it can achieve acceptable recommendation accuracy.
WORKING WITH THOSE WHO THINK OTHERWISE

Field: Arts and Humanities (Social Sciences)

This essay is one of three published in response to Casper Bruun Jensen's article “Experiments in Good Faith and Hopefulness: Toward a Postcritical Social Science” (Common Knowledge 20, no. 2 [Spring 2014]: 337 – 62), which concerns the “postcritical” work of Helen Verran, Richard Rottenburg, and Hirokazu Miyazaki. Verran's response clarifies the stance that she takes in her work, and especially in her book Science and an African Logic (2001), toward critique. Here she argues that critique involves grasping the difference between entities in the here-and-now, while conventional analysis in the social sciences explains away difference in the here-and-now by relocating it to an ideal realm. She explains that the method she has developed is a form of infra critique — a way of “doing difference” that keeps it present, particular, and localized. Her essay concludes that the shift to infra critique requires that the “good faith analyst” make her own ontological commitments explicit and accept responsibility for making judgments.