jimnoneill/paper-to-field-training huggingface dataset:
A complex-number multiplier using radix-4 digits

Field: Computer Science (Physical Sciences)

This paper describes the design of a 16/spl times/16 complex-number multiplier developed as part of the arithmetic datapath of a complex-number digital signal processor. The complex-number multiplier internally uses binary signed digits for fast multiplication and compact layout. It employs the traditional three-multiplication scheme while minimizing the logic and delay associated with the three extra pre-multiplication binary additions which that scheme requires. The minimization comes from producing the redundant binary sum for each of the pre-multiplication binary additions with minimal hardware, and then recoding the redundant sums as radix-4 multiplier operands. The radix-4 operands halve the number of summands to be added in each of the three real multiplier units. Furthermore, an additional factor of two reduction in the number of summands is effectuated by our coding scheme for representing binary signed digits. The result is a fast and compact complex-number multiplier.< >
Clinical and experimental study on effect of Zhao's Weitiao III decoction on colorectal cancer.

Field: Medicine (Health Sciences)

Objective:To investigate the clinical and experimental effect of Zhao's Weitiao Ⅲ decoction on colorectal cancer.Methods:Clinical study:After oral administration of Zhao's Weitiao Ⅲ decoction,main symptoms,quality of life,clinical curative effect and survival rate of the patients were observed.Experimental study:Zhao's Weitiao Ⅲ decoction was observed by the antitumor effect on transplanted sarcoma,the influence on cytokine of experimental animal and the inhibition and apoptosis of HT-29 and LOVO cells.Results:Clinical study:Zhao's Weitiao Ⅲdecoction could improve patients’ main symptoms(the total effective rate was 89.52%),improve patients’ quality of life(P0.05),maintain the stability of tumor(the rate of partial response and stable disease was 86.67% ),prolong survival time(3-year survival rate was 49.52%).Experimental study:The rate of antitumor effect of Zhao's Weitiao Ⅲ decoction was 29.68%.It could raise obviously the level of cytokine of IL-2,IL-4,IFN-γ and induce the apoptosis of HT-29 and LOVO cells.Conclusions:Zhao's Weitiao Ⅲ decoction could improve patients’ main symptoms and quality of life,suppress tumor growth,induce the apoptosis of malignant cells,and prolong survival.
Brucella Outer Membrane Lipoproteins Share Antigenic Determinants with Bacteria of the Family Rhizobiaceae

Field: Immunology and Microbiology (Life Sciences)

ABSTRACT Brucellae have been reported to be phylogenetically related to bacteria of the family Rhizobiaceae . In the present study, we used a panel of monoclonal antibodies (MAbs) to Brucella outer membrane proteins (OMPs) to determine the presence of common OMP epitopes in some representative bacteria of this family, i.e., Ochrobactrum anthropi , Phyllobacterium rubiacearum , Rhizobium leguminosarum , and Agrobacterium tumefaciens , and also in bacteria reported to serologically cross-react with brucella, i.e., Yersinia enterocolitica O:9, Escherichia coli O:157, and Salmonella urbana . In particular, most MAbs to the Brucella outer membrane lipoproteins Omp10, Omp16, and Omp19 cross-reacted with O. anthropi and P. rubiacearum , which are actually the closest relatives of brucellae. Some of them also cross-reacted, but to a lower extent, with R. leguminosarum and A. tumefaciens . The putative Omp16 and Omp19 homologs in these bacteria showed the same apparent molecular masses as their Brucella counterparts. None of the antilipoprotein MAbs cross-reacted with Y. enterocolitica O:9, E. coli O:157, or S. urbana .
Molecular Mechanisms Behind the Dose-Dependent Differential Activation of MAPK Pathways Induced by Transforming Growth Factor-<I>β</I>1 in Hematopoietic Cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Transforming growth factor-β (TGF-β) controls a wide range of cellular responses, including cell proliferation, lineage determination, differentiation, and apoptosis, and figures prominently in animal development. It is considered as a pleiotropic factor because it can exert a positive or negative effect on various cellular processes depending on developmental stage of the target cell, its microenvironment, and also its biochemical make up. It has been shown to have a strong inhibitory effect on hematopoietic stem cell proliferation and differentiation. We have earlier shown that TGF-β1 exerts a bidirectional effect on hematopoietic cell proliferation as a function of its concentration. Although it acted as an inhibitor at high concentrations, at low concentrations it stimulated the stem/progenitor cells. We also provided evidence that the differential activation of mitogen-activated protein kinase pathways was responsible for the observed bidirectional effect. In the present study, we examined the molecular mechanism behind this phenomenon. We observed that the high inhibitory concentrations of TGF-β1 induced a strong phosphorylation of SMAD 3 and also activated stress kinase-related transcription factors, namely c-Jun and ATF-2. On the other hand, low stimulatory concentrations acted in a SMAD 3-independent pathway and activated STAT proteins. Our results clearly show that differential activation of signal transduction pathways by TGF-β1 as a function of its concentration underlies its bidirectional effect on hematopoietic cells.
Detection of neuroblastoma cells in blood by reverse transcriptase-polymerase chain reaction.

Field: Medicine (Health Sciences)

These systems allow the detection of circulating NB cells with higher sensitivity and specificity. When RT-PCR is clinically used for the detection of NB cells in blood, that both PGP 9.5 and TH should be selected is recommended. The assessment of bone marrow alone might not be used as a single index of tumor dissemination.
Aligning data architecture and data governance

Field: Computer Science (Physical Sciences)

Data Governance is a management structure that is layered on top of data to ensure that it is identified, registered, categorized, and handled in a consistent manner. Its role is to make decisions about data ownership and data maintenance over the course of the data life cycle, data quality, and data compliance. It also defines and regulates the rules for data usage, access, aggregation, and flow. Data architecture is becoming increasingly crucial for enterprises to design, improve, record, and maintain. This is partly due to a growing desire for access, data integration, and data exchange with other parties, as well as legally mandated insights into internal data flows. It brings standardization to names and, most importantly, definitions of entities across the organization. Data governance and data architecture may have a different emphasis and focus, but they are mutually reinforcing. Organizations with governance processes have a relationship with data architecture processes that come into alignment. The architecture is completely implicit but correlates to the prime functions of data In the end, an organisation needs both. We need data governance and data architecture, and we don't want to be in a situation where one stands in the way of the other. For both, there is a different model, but the aim is to construct another model that allows combining the two. The main objective of this thesis is to Develop a model that covers and complements both the data architecture and the data governance.
Cardiorespiratory Responses of Trained Boys to Treadmill and Arm Ergometry: Effect of Training Specificity

Field: Medicine (Health Sciences)

The purpose of this study was to examine the maximal cardiorespiratory responses of trained adolescent male swimmers (SWM, N = 18), soccer players (SOC, N = 18), and moderately active reference subjects (CON, N = 16) to treadmill running (TRD) and arm ergometry (ARM). Mean values (± SD )for skeletal age were similar among the three groups (12.5± 1.9, 12.7 ± 1.1, and 12.5 ± 1.6 years, for the SWM, SOC, and CON, respectively). Allometric scaling procedures, relating VO 2 max and body mass, were used and mass exponents of .80 and .74 were identified for TRD and ARM data, respectively. During TRD testing SOC attained significantly higher VO 2 max values when expressed in ml · kg −1 · min −1 , or ml · kg −0.80 · min −1 than the other two groups. However, during ARM testing, the SWM achieved significantly higher VO 2 peak values (ml · kg −0.74 · min −1 and scaled to arm-CSA) than SOC. The ratio of ARM-VAT to TRD-VAT was significantly higher in SWM (50.1± 9%) compared to SOC (41.2±5%), or CON (41.9 ± 6%).
Characteristics of sea-urchin mitotic apparatus isolated using a dimethyl sulphoxide/glycerol medium

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ABSTRACT A method for isolating sea-urchin zygote mitotic apparatus (MA) is described which is based on the Filner-Behnke method of isolating brain microtubules. MA were isolated in 50% (v/v) glycerol, 10% (v/v) dimethyl sulphoxide, 5 mM MgCl2, 0·1 mM EGTA, and 5 mM Sorensen’s phosphate buffer at a final pH of 6·8. MA stored at room temperature in isolation medium had stable birefringence, stable microtubules, and stable solubility properties (in 0·5 M KC1) over a period of 10 days to 2 weeks. These MA also seem to have more dry matter per volume than do MA isolated using hexylene glycol. The biggest disadvantages of the method are that zygotes often are difficult to lyse, and that cytoplasmic debris the same size as the MA sometimes contaminates the MA pellet.
Protein-Directed Modulation of High-LET Hyperthermic Radiosensitization

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

A pair of Chinese Hamster Ovary cell lines, the wild-type CHO-SC1, and its temperature-sensitive mutant (CHO-tsH1) was used to examine the importance of protein synthesis in the development of thermotolerance. The classical diphasic thermotolerant survival response to hyperthermia was observed in the SCI cells after continuous heating at 41.5°C to 42.5°C, while tsHl showed no thermotolerance. In separate experiments, each cell line was triggered and challenged at 45°C. The heat doses were separated with graded incubation periods at 35°C or 40°C for thermotolerance development. SCI cells expressed thermoresistance, with the synthesis of heat shock proteins, under both incubation conditions. tsH1 cells expressed thermotolerance similar to that seen in the SCI cells when incubated at 35°C, but the survival response with the non-permissive 40°C incubation was much reduced in the absence of protein synthesis. It is therefore postulated that the synthesis of new cytosol proteins is not required for the initial onset of thermotolerance but is necessary for the sustenance of tolerance. The combined effects of heavy-ion radiation and hyperthermia were examined using the same cell system. A mild heat dose of 41.5°C was used in conjunction with Neon particle radiation of various high LET values. The cell killing effects were highly dependent on the sequence of application of heat and Neon radiation. Heat applied immediately after Neon irradiation was more cytotoxic to SCI cells than when heat was applied prior to the irradiation. The ability of cells to synthesize new proteins plays a key role in this sequence-dependent thermal radiosensitization. In the absence of protein synthesis in the tsH1 cells, the high-LET thermal enhancement for cell-killing was unchanged regardless of the sequence. In the presence of protein synthetic activity in the SCI cells, the thermal enhancement of radiation-induced cell killing was LET-dependent. Furthermore, the RBE of heated-SCl cells varied with the LET value and reached a maximum of >3, while a reduced maximum RBE of 2.6 was obtained for the heated-tsH1 cells. These results suggest that high-LET radiation induced cellular damage can be potentiated with heat-induced new protein synthesis during post-irradiation heat treatment.
Some applications in forestry of biological digital image processing

Field: Agricultural and Biological Sciences (Life Sciences)

It is shown that chromatin (DNA) distribution patterns in the nuclei of insect cells provide predictors related to the future development of the insect population. The patterns are extracted from digital images of the nuclei. The systems described have been implemented at the Pacific Forestry Centre. In previous reports this has been demonstrated in laboratory populations; here it is demonstrated for field populations and therefore has great significance for forest managers. Systems for nematodes and electrophoresis gels are also described. There are many such opportunities in forestry to apply biological digital image processing for the extraction of information that is not evident to the human eye-brain combination.< >
Talk to Papers: Bringing Neural Question Answering to Academic Search

Field: Computer Science (Physical Sciences)

We introduce Talk to Papers, which exploits the recent open-domain question answering (QA) techniques to improve the current experience of academic search. It's designed to enable researchers to use natural language queries to find precise answers and extract insights from a massive amount of academic papers. We present a large improvement over classic search engine baseline on several standard QA datasets and provide the community a collaborative data collection tool to curate the first natural language processing research QA dataset via a community effort.
Back-arc extension in the Scotia Sea

Field: Earth and Planetary Sciences (Physical Sciences)

The nature of back-arc extension in the East Scotia Sea is re-examined with the use of an enlarged geophysical data set. Well developed oceanic magnetic lineations confirm that the present spreading episode started about 8 Ma ago, that spreading is asymmetric, and that the total rate increased from 50 to 70 m m /a about 1.5 Ma ago. Most of the currently active South Sandwich volcanic island arc lies upon ocean floor only 6-8 M a old and generated at the current spreading ridge. Subsequent extension has not modified the curvature of the arc. East-west magnetic lineations of Miocene age in the Central Scotia Sea and contemporaneous low-K arc tholeiites dredged from the eastern South Scotia Ridge (Discovery Bank) indicate a regime of coupled subduction and back-arc extension preceding that occurring now. A speculative model involving a series of collisions of parts of this earlier Discovery trench with ridge crest sections of the South American-Antarctic plate boundary explains the transformation of this earlier regime into the present, self-contained Sandwich plate regime. The considerable small-scale variability observed in the back-arc region may be seen as an inevitable consequence of the action of the ridge-trench collision mechanism. The entire Scotia Sea could have formed by a similar kind of back-arc extensional modification of the South American-Antarctic plate boundary.
The importin-β binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The nuclear localization signal (NLS) of spliceosomal U snRNPs is composed of the U snRNA's 2,2,7-trimethyl-guanosine (m3G)-cap and the Sm core domain. The m3G-cap is specifically bound by snurportin1, which contains an NH2-terminal importin-β binding (IBB) domain and a COOH-terminal m3G-cap–binding region that bears no structural similarity to known import adaptors like importin-α (impα). Here, we show that recombinant snurportin1 and importin-β (impβ) are not only necessary, but also sufficient for U1 snRNP transport to the nuclei of digitonin-permeabilized HeLa cells. In contrast to impα–dependent import, single rounds of U1 snRNP import, mediated by the nuclear import receptor complex snurportin1–impβ, did not require Ran and energy. The same Ran- and energy-independent import was even observed for U5 snRNP, which has a molecular weight of more than one million. Interestingly, in the presence of impβ and a snurportin1 mutant containing an impα IBB domain (IBBimpα), nuclear U1 snRNP import was Ran dependent. Furthermore, β-galactosidase (βGal) containing a snurportin1 IBB domain, but not IBBimpα-βGal, was imported into the nucleus in a Ran-independent manner. Our results suggest that the nature of the IBB domain modulates the strength and/or site of interaction of impβ with nucleoporins of the nuclear pore complex, and thus whether or not Ran is required to dissociate these interactions.
Gemfibrozil as a Lipid Lowering Compound in Hyperlipoproteinæmia. A Placebo-controlled Cross-over Trial

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The efficacy of gemfibrozil in lowering increased serum lipoprotein concentrations was tested in a placebo-controlled cross-over trial on 30 patients. Administered in a dose of 1200 mg daily, gemfibrozil reduced increased serum triglyceride levels by approximately 50% and reduced increased serum cholesterol concentrations by about 20%. Elevated VLDL triglyceride levels were reduced by 60%, and increased LDL cholesterol concentrations were reduced by approximately 20%. The mean HDL cholesterol concentration increased during gemfibrozil treatment. No adverse reactions attributable to gemfibrozil were recorded during the trial.
Unleashing the Potential of Artificial Intelligence in Education: Implications for Teaching and Learning Results

Field: Social Sciences (Social Sciences)

It’s interesting to see how the use of artificial intelligence (AI) in education is becoming increasingly prominent due to the rapid growth of AI technology. One of the main benefits of using AI techniques for teaching and learning is the potential to raise the standard of instruction. The present study explores the benefits and difficulties of incorporating AI in higher education institutions and the challenges students face in embracing the technology. The study also examines the challenges teachers face while using AI in their teaching, and how AI can help them teach more effectively and efficiently. The study is targeted towards students and teachers, a sample of 337 responses were collected and analyzed using SPSS and Microsoft Excel. According to the study, most teachers and students are aware of artificial intelligence (AI) tools, and they highly appreciate the effectiveness of AI in education. Participants emphasized that AI can be useful in promoting creative teaching strategies, developing study materials, and enhancing problem-solving skills. Furthermore, the study found that AI has a positive impact on academic performance. Therefore, the use of AI can positively influence the teaching and learning process.
Examining the Restriction of Human Rights in Government Regulation in Lieu of Law

Field: Social Sciences (Social Sciences)

Abstract:The implementation of human rights (HAM) in Indonesia can be restricted while its implementation is violated others’ rights, or contradicted to moral considerations, religious values, security, and public order. This limitation is referring to article 28 J of the 1945 Constitution of the Republic of Indonesia (UUD 1945) which has been regulated under the law. Besides, can human rights restrictions also be stipulated through legal products in the form of Government Regulation in Lieu of Law or Perppu? This question is build upon the understanding that Perppu is equated with the law in the hierarchy of statutory regulations. Nevertheless, Perppu that formed in a precarious and a hurry situation must consist of material content restrictions on crucial matters including human rights restriction. The limitation contents of the Perppu should become concern since it must be applied with the extra caution and consideration. As a result, the Perppu which was compiled under abnormal conditions should not be justified in regulating human rights restriction.Key Word: Human Right, Restriction of Human Right, Perppu
PREP: Predicting Job Runtime with Job Running Path on Supercomputers

Field: Computer Science (Physical Sciences)

Supercomputers serve a lot of parallel jobs by scheduling jobs and allocating computing resources. One popular scheduling strategy is First Come First Serve (FCFS). However, there are always some idle resources not being effectively utilized, since they are not enough and are reserved for the head job in the waiting queue. To improve resource utilization, a common solution is to use backfilling, which allocates the reserved computing resources to a small, short job selected from the queue, on the premise of not delaying the original head job. Unfortunately, the estimated job runtime provided by users is often overestimated. Previous studies extract features from historical job logs and predict runtime based on machine learning. However, traditional features (e.g. CPU, user, submitting time, etc.) are insufficient to describe the characteristics of jobs. In this paper, we propose a novel runtime prediction framework called PREP. It explores a new feature named job running path, which encodes important implications about the job's characteristics, such as the project it belongs to, data sets and parameters it uses, etc. As there is a strong correlation between job runtime and its running path. PREP groups jobs into separate clusters according to their running paths and trains a runtime prediction model for each job cluster. Final results demonstrate that adding the new feature can achieve high prediction accuracy of 88% and has a better prediction effect than other methods, such as Last-2 and IRPA.
Social Inclusion or Gender Equality? Political Discourses on Parental Leave in Finland and Sweden

Field: Social Sciences (Social Sciences)

During the 2010s, both Finland and Sweden made advancements in their parental leave systems by widening the right to paid parental leave to a greater diversity of family constellations and investing in gender-equal leave distribution through longer leave periods reserved for the father. However, in the latter respect, Sweden has remained more successful than Finland. This article analyses government and political party discourses in Finland and Sweden during the 2010s in pursuit of an explanation to this difference and for understanding how ideas on social inclusion and gender equality have been used to drive, or block, policy reforms in the field of parental leave. The results show that the parental leave discourses have become influenced by ideas on social inclusion and gender equality in both countries, but in somewhat different ways. While gender equality has retained a stronger position in the Swedish discourse and its policy, social inclusion, and notably the rights of same-sex parents, have become more visible in the Finnish. However, the results also show that both ideas have remained contested on a party level, especially by confessional and nationalist-populist parties.
Penggunaan E-Learning Sebagai Media Interaktif Dalam Pembelajaran Dalam Jaringan (Daring)

Field: Social Sciences (Social Sciences)

Technology was an important role in the world of education, especially in the teaching and learning process where during the spread of the Covid-19 virus, all activities were transferred to remote or online (online) including learning carried out remotely through various technological media, one of the technologies used This is E-Learning, where e-learning is considered efficient in collecting assignments and providing learning materials, but even though online learning is considered to have advantages and looks fun because it can be done from home, it is not easy to do. This study aims to find out how important the use of E-learning is in the teaching-learning process during the Covid-19 period.