jimnoneill/paper-to-field-training huggingface dataset:
Remembering Japanese Militarism Through the Fusosha Textbook: The Collective Memory of the Asian-Pacific War in Japan

Field: Social Sciences (Social Sciences)

The Japanese Ministry of Education's approval of a junior high school history textbook justifying Japan's aggressive acts during the Pacific War has been criticized by the governments of several Asian countries, and became an important topic in anti-Japan protests in China and South Korea in April 2005. The textbook screening decisions made by the Japanese Ministry of Education have not only led to international protests, but they have also resulted in significant conflict within Japan, illustrated by a history of protests and lawsuits. This article examines the controversial textbook published by the Fusosha Publishing House and attempts to provide an understanding of the war memories promoted by the book. Furthermore, the article discusses the relationship between this appropriation of war memories and the rise of militarism in contemporary Japan.
A portable breast cancer imaging system with cross-shaped dome antenna array

Field: Engineering (Physical Sciences)

Imaging of a breast cancer phantom was demonstrated by use of radar-based ultra-wide-band (UWB) complementary metal oxide semiconductor integrated circuits (CMOS) with 16 cross-shaped dome array antennas on a hemispherical breast phantom. The dome antenna array was rotated and the combinations of transmitter and receiver antennas were selected by two CMOS switching matrices. A breast cancer phantom target in a silicone-based breast phantom was successfully detected by confocal imaging.
Experimental investigation of electrode wear assessment in the EDM process using image processing technique

Field: Engineering (Physical Sciences)

Abstract One of the widespread non-traditional and non-contact machining processes is the electrical discharge machining (EDM) process, which depends on removing material from the surface by different repeat electrical discharges between a machined workpiece and a cutting tool called the electrode. The electrode wear in the EDM process is one of the parameters of significant technological interest. This article proposed a reliable image-based system that automatically detects and computes electrode wear in EDM of rectangular steel workpiece plate of AISI 314 using a copper electrode with a rectangular shape. MATLAB environment and image processing toolbox are used to identify and manipulate the captured rectangular electrode image for rectangular electrode data extraction needed for the electrode wear identification process. The results show that the proposed image-based approach, using a non-contact measuring system and relatively inexpensive equipment, is suitable with good accuracy and efficiency for measuring and testing electrode wear.
Stapled Hemorrhoidopexy: Outcome Assessment

Field: Medicine (Health Sciences)

Since its introduction as a new procedure for the surgical management of hemorrhoidal disease in 1993, stapled hemorrhoidopexy has become increasingly popular. This has been mostly the result of the reported reduction in postoperative pain. This study was designed to review retrospectively 152 patients combined from a 3-year period in a three-surgeon private colorectal practice and a 1-year period from an academic colon and rectal surgery training program. All patients had either grade II or III hemorrhoidal prolapse. There were 78 male (mean age, 52 years) and 74 female patients (mean age, 54 years). A total of 133 patients (87.5%) were treated on an ambulatory basis, with 131 patients (86%) given monitored sedation with local anesthesia. Postoperative complications were seen in 49 patients (32%); 33 were for bleeding, with four requiring operative control. Subsequent associated anorectal procedures were performed on 14 patients (9.2%). Of the original 152 patients, 78 participated in a postoperative survey. Of these patients, 67.9 per cent stated that their postoperative pain was less than expected. Seventy-one patients (91%) stated significant improvement or complete resolution of their symptoms, and 73.1 per cent returned to normal activity in less than 2 weeks. Eighty-nine per cent of patients surveyed stated they would recommend hemorrhoidopexy to others.
P03.11 Exploring tumor-intrinsic factors regulating the recruitment of myeloid-derived suppressor cells (MDSC) in pancreatic ductal adenocarcinoma

Field: Medicine (Health Sciences)

Background

Pancreatic Ductal Adenocarcinoma (PDAC) has very poor 5-year overall survival rate. Despite the encouraging effect of immunotherapy in other cancer types, clinical benefit in PDAC patients remains limited. One of the reasons for the lack of success is the immunosuppressive tumor microenvironment (TME), which is maintained by myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages. High MDSC infiltration is associated with a poor survival in PDAC patients. Our project aims at identifying tumor-driven chemokines that influence recruitment of MDSC and establishment of the immunosuppressive tumor microenvironment.

Materials and Methods

45 PDAC cell lines generated from spontaneous tumors of genetically-modified mice harboring the characteristic driver mutations KrasG12D or PIK3CAH1047R were analyzed for their expression levels of CXCL1, CCL2, G-CSF and GM-CSF by qRT-PCR. In order to study the relationship between the chemokine/cytokine profile and the immune cell infiltration, selected tumor cell lines were implanted orthotopically in C57BL6 mice. Three weeks after inoculation blood, spleen and tumor were isolated and organ specific immune cell infiltration was analyzed by flow cytometry. To further characterize tumor-secreted factors tumor conditioned medium was generated and the concentration of 33 chemokines was analyzed in a multiplex assay. The chemokine levels were correlated with migratory capacity of splenic MDSC measured in an ex vivo chemotaxis assay.

Results

CXCL1 significantly enhanced migration of polymorphonuclear MDSC (PMN-MDSC) in vitro, while migration of monocytic MDSC (M-MDSC) was predominantly skewed towards CCL2. Three weeks after tumor inoculation, MDSC populations in blood and spleen were expanded. Most intriguingly, PDAC cell lines with high CXCL1 or CCL2 levels in vitro showed significantly enriched intratumoral accumulation of PMN-MDSC and M-MDSC, respectively, suggesting that tumor-intrinsic chemokine secretion and not factors from the tumor stroma determined MDSC infiltration. The ex vivo chemotaxis assays revealed additional factors that modulate migration of MDSC into the TME.

Conclusions

The in vitro gene expression levels of individual chemokines (CXCL1 and CCL2) determines the MDSC infiltration in vivo into the TME. Targeting the chemokine-receptor axis of MDSC subpopulations could be a promising approach in the treatment of pancreatic cancer.

Funding

The project was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - Projektnummer 329628492 - SFB 1321 and the Förderprogramm für Forschung und Lehre (FöFoLe) funded by the Ludwig-Maximilians-Universität München.

Disclosure Information

C. Rambuscheck: None. P. Metzger: None. C. Hörth: None. R. Hennel: None. S. Bärthel: None. C. Falcomatà: None. K. Lauber: None. S. Endres: None. D. Saur: None. M. Schnurr: None. L.M. König: None.
TRPM7: Channeling the Future of Cellular Magnesium Homeostasis?

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

A recent paper by Schmitz and colleagues provides persuasive evidence that the ion channel transient receptor potential melastatin 7 (TRPM7) may be the long-sought regulator of magnesium (Mg) homeostasis in mammalian cells. This finding is not unexpected, because TRPM channels contain a kinase domain that allows them to participate in signal transduction pathways and regulatory networks. However, these studies introduce an exciting new twist into our understanding of Mg homeostasis; TRPM7 facilitates Mg entry into the cell, whereas other putative Mg transporters apparently operate in the opposite direction. By combining electrophysiological, biochemical, and genetic approaches, Schmitz and colleagues characterized most of the key features that demonstrate a well-defined and biologically plausible regulator of Mg homeostasis. TRPM7 genetics are well in hand, its regulation by intracellular free Mg 2+ unravels the mechanisms of regulatory feedback loops, and its kinase domain modulates its sensitivity to free Mg 2+ . These findings are discussed in light of the indirect and descriptive information we had about Mg regulation before this rigorous characterization of TRPM7 brought it to the center of the Mg stage. Although the molecular events downstream of TRPM7 phosphorylation and dephosphorylation await in-depth elucidation, these results open up exciting perspectives in Mg research and may provide a much-needed tool with which to reexamine the role of Mg in cell proliferation and other important pathophysiologic events. Likewise, these findings will offer guidelines for research on disease states that are characterized by Mg imbalance.
EFFECT OF FEEDING UREA TREATED WHEAT STRAW WITH OR WITHOUT SULPHUR ON NITROGEN UTILIZATION AND GROWTH RATE IN CROSSBRED HEIFERS

Field: Agricultural and Biological Sciences (Life Sciences)

This experiment was conducted on twenty five crossbred heifers randomly divided into five treatment groups of five animals each. The five treatments were: T1 (Wheat straw), T2 (1.5% urea treated wheat straw), T3 (1.5% urea plus 0.5% single super phosphate treated wheat straw), T4 (4% urea ammonia treated wheat straw) and T5 (4% urea ammonia plus 1.5% single super phosphate treated wheat straw). The average daily nitrogen intake for treatments T1, T2, T3, T4 and T5 was 82.82, 91.76, 102.89, 129.59 and 150.18 g/day/animal, respectively. The overall differences in nitrogen intake between treatments were highly significant (P<0.01). All the animals were in positive nitrogen balance and the difference was statistically significant (P<0.01). Weight gain and nitrogen retained as per cent of the total nitrogen intake was higher in treatment T5 and the difference was statistically significant (P<0.01) among the treatment groups. It may be concluded that sulphur supplementation to urea treated wheat straw based diets has beneficial effect on nitrogen utilization and growth rate in crossbred heifers.
Occurrence Download

Field: Agricultural and Biological Sciences (Life Sciences)

A dataset containing 264 species occurrences available in GBIF matching the query: { "TaxonKey" : [ "is Rhododendron glischrum" ] } The dataset includes 264 records from 21 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0018821-250920141307145/datasets/export for details. Data from some individual datasets included in this download may be licensed under less restrictive terms.
Oxygen vacancy effects on double perovskite Bi 2 FeMnO 6 : A first-principles study

Field: Physics and Astronomy (Physical Sciences)

Double perovskite Bi2FeMnO6 (BFMO) is a potential candidate for the highly sought single-phase multiferroic system. The large orbital radius of the Bi 6s2 lone pairs is responsible for BFMO to exhibit low symmetries and spontaneous polarization, whereas B-site ordering of Mn and Fe contributes to its magnetic properties. In this work, we study both electronic correlation and oxygen vacancy effects on magnetic, electronic and optical properties of BFMO by performing first-principles simulations using density functional theory within the local spin-density approximation (LSDA) and the LSDA+U method. We have numerically demonstrated that a strong on-site Hubbard interaction is critical for the gap opening in a pristine BFMO. We have performed calculations on a supercell constructed with eight chemical formula units of BFMO, from which oxygen atoms were removed incrementally. We showed that the average magnetization decreases with the increase of oxygen vacancy concentration. From the calculated band structure and optical conductivity, an insulator-metal transition or crossover was identified with oxygen in BFMO.
Medical Education Teaching Cultural Sensitivity through Literature and Reflective Writing

Field: Health Professions (Health Sciences)

Teaching cultural competence to medical students in a meaningful way is challenging. Trying to teach cultural communication as a measurable skill oversimplifies both the complexities of culture, race, and ethnicity and their effect on the medical interaction. We want to embrace cultural understanding but avoid cultural stereotyping. To ask medical students to learn all the characteristics of a culture potentially categorizes future patients, thus denying them individual identity within the broader racial, ethnic, or cultural label we apply to them. For some, this approach has been denigrated as “political correctness, ” while, from the standpoint of the patient who is pre-judged by his or her label, it can seem racist. “Cultural humility, ” a concept initially described by Drs. Tervalon and Murray-Garcia [1] is not only more respectful but also more pedagogically sound. Cultural humility asks physicians to understand their own culture(s) as well as that of the patient and view this understanding as a lifelong process of self-reflection and self-critique. If cultural humility is viewed thus, it may encourage the process of personal and professional growth.
Green Companies or Green Con‐panies: Are Companies Really Green, or Are They Pretending to Be?

Field: Business, Management and Accounting (Social Sciences)

© 2005 Center for Business Ethics at Bentley College. Published by Blackwell Publishing, 350 Main Street, Malden, MA 02148, USA, and 9600 Garsington Road, Oxford OX4 2DQ, UK. Blackwell Publishing, Ltd. Oxford, UK ASR usiness and Society Review 0045-3609 © 2005 Ce ter f r Busin ss Ethics at Bentley College ??? 2005 12 rigi al Article U INESS and SOCIETY REVIEW S HA and DARNTON Green Companies or Green Con-panies: Are Companies Really Green, or Are They Pretending to Be?
Forecasting Intraday stock price trends with text mining techniques

Field: Computer Science (Physical Sciences)

In this paper, we describe NewsCATS (news categorization and trading system), a system implemented to predict stock price trends for the time immediately after the publication of press releases. NewsCATS consists mainly of three components. The first component retrieves relevant information from press releases through the application of text preprocessing techniques. The second component sorts the press releases into predefined categories. Finally, appropriate trading strategies are derived by the third component by means of the earlier categorization. The findings indicate that a categorization of press releases is able to provide additional information that can be used to forecast stock price trends, but that an adequate trading strategy is essential for the results of the categorization to be fully exploited.
On the Range of Applicability of the ReissnerMindlin and KirchhoffLove Plate Bending Models

Field: Mathematics (Physical Sciences)

Abstract. We show that the Reissner–Mindlin plate bending model has a wider range of applicability than the Kirchhoff–Love model for the approximation of clamped linearly elastic plates. Under the assumption that the body force density is constant in the transverse direction, the Reissner–Mindlin model solution converges to the three-dimensional linear elasticity solution in the relative energy norm for the full range of surface loads. However, for loads with a significant transverse shear effect, the Kirchhoff–Love model fails. 1.
Histopathology of the thymus of patients with acute lymphoblastic leukemia and lymphoblastic lymphoma in complete clinical remission

Field: Medicine (Health Sciences)

The histologic features of thymuses from three patients who underwent thymectomy for acute lymphoblastic leukemia or lymphoblastic lymphoma in complete clinical remission are described. The thymuses from all three patients were fibrotic with a variability in the appearance of the lobules. Some of the lobules consisted predominantly of epithelial cells with small numbers of mature appearing lymphocytes, while other lobules were expanded and composed predominantly of cells having morphological features of immature lymphoid cells consistent with residual or recurrent disease.
Crystal structure of 2-(3,5-dimethoxyphenylamino)-3-chloronaphthalene-1,4-dione

Field: Chemistry (Physical Sciences)

2-(3,5-Dimethoxyphenylamino)-3-chloronaphthalene-1,4-dione compound was prepared from the nucleophilic substitution reaction of 2,3-dichloro-1,4-naphthoquinone with 3,5-dimethoxyphenylamine at reflux temperature according to literature reported previously. Single-crystal X-ray diffraction analysis was carried out to confirm the structure of the title compound. The title compound, C18H14ClNO4, crystallizes in the triclinic space group P-1, a = 7.0016(6) Å, b = 7.7937(6) Å, c = 15.6218(11) Å, β = 97.238(4)°, V = 782.44(11) Å3, Z = 2, R1 = 0.0525, wR2 = 0.1329. KEY WORDS: Naphthoquinones, Aminochloronaphthoquinone; X-Ray diffraction Bull. Chem. Soc. Ethiop. 2018, 32(3), 603-608.DOI: https://dx.doi.org/10.4314/bcse.v32i3.18
Vasodilator drugs in the treatment of hypertension

Field: Medicine (Health Sciences)

Treatment with vasodilating drugs specifically reverses the major hemodynamic abnormality of primary hypertension. Hypotensive effectiveness of vasodilators is limited by three responses of hypertensives to vasodilation-induced blood pressure reduction, including reflex increases in sympathetic activity that raise cardiac output, augmentation of plasma renin activity, and sodium retention with plasma volume expansion. Concomitant administration of propranolol suppresses the first and second responses, and diuretics prevent the third. In treating chronic hypertension, vasodilators should be coadministered with both drugs. Potentiated in this fashion, well-tolerated doses of hydralazine (200 mg/day) can normalize the hemodynamics of most hypertensives. Guancydine and, particularly, minoxidil are promising antihypertensive vasodilators but remain in the investigative stages. Nitroprusside and diazoxide are powerful intravenous vasodilators and are effective for hypertensive emergencies. They differ in time course of action and in effect on cardiac output.
Cardiogenic Shock Due to Coronary Artery Stent Thrombosis

Field: Medicine (Health Sciences)

Stent thrombosis is an uncommon but serious complication that causes sudden death or myocardial infarction (MI). A large MI, especially with ST elevation, can cause cardiogenic shock and pose a significant incidence of morbidity and mortality. Largeness of ischemic territory is the main reason that causes cardiogenic shock. The fundamental treatment strategies are immediate coronary revascularization and perfusion support to avoid end organ damage with medically or mechanical in intensive care units. The prevention, incidences, mechanisms, management, and clinical impacts of cardiogenic shock discussed under this topic.
Design and Modeling for Hybrid Driven Knee Orthosis with SMA actuator

Field: Engineering (Physical Sciences)

In this paper, a hybrid driven knee orthosis using Shape Memory Alloy (SMA) actuator is proposed. First, the mechanical design of the actuator system is presented. The device mainly consists of the DC motor module and the SMA spring actuator module, and the two independent operating actuators realize the hybrid drive through the electromagnetic clutch connection. Then, the constitutive model for SMA spring and mathematical model for DC motor system are established respectively to describe the output characteristics of the actuator. Finally, a series of numerical simulations are implemented on SMA springs and the DC motor to determine the changing parameters of the SMA actuator during the heating phase transition and the load characteristics of the motor.
Resource Allocation Technique for Hybrid TDMA-NOMA System with Opportunistic Time Assignment

Field: Computer Science (Physical Sciences)

In this paper, we develop a resource allocation technique for a hybrid time division multiple access (TDMA) - non-orthogonal multiple access (NOMA) system with opportunistic time assignment. In particular, the available transmission time is divided into several time-slots, through which multiple users are served by exploiting power-domain NOMA. To fully exploit underlying benefits of this hybrid TDMA-NOMA system, we utilize the available resources efficiently by jointly allocating transmit power and time-slots to several groups of users in the system. Furthermore, these resources are allocated to maximize minimum rate of the users in the system. However, this max-min resource allocation problem is non-convex due to coupled design parameters of time and power allocations. Hence, we exploit a novel second-order cone formulation to overcome this non-convexity issue and develop an iterative algorithm to realize a solution to the original max-min problem. Simulation results show that this joint resource allocation technique has a considerable performance enhancement in terms of both minimum achieved rate and overall system throughput compared to that of the conventional resource allocation technique where equal time-slots are assigned to the groups of users.
Rapid Quantification of Irinotecan In Rat Plasma By Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry-Application To Preclinical Pharmacokinetics

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

A simple rapid and robust method for quantification of irinotecan in rat plasma has been established using liquid chromatography-electrospray ionization tandem mass
spectrometry (LC-ESI/MS/MS). Imipramine was used as an internal standard. Irinotecan and internal standard in plasma sample was extracted using simple liquid-liquid
extraction. The samples were injected in to a C18 reversed-phase column and mobile phase used was acetonitrile – 0.1% formic acid in water (90:10, %v/v) at a flow rate of 0.5 ml/min. using MS/MS in the selected reaction-monitoring (SRM) mode, Irinotecan and Imipramine were detected without any interference from rat plasma matrix. Irinotecan roduced a precursor ion ([M+H]+) at m/z 587.20 and a corresponding product ion at m/z 167.01 The internal standard produced a precursor ion ([M+H]+) at m/z 281.20 and a corresponding product ion at m/z 86.19. Detection of Irinotecan in rat
plasma by the LC-ESI/MS/MS method was accurate and precise with a quantitation limit of 10ng/ml. The proposed method was validated with linear range of 10 - 4000 ng/ml.
Reproducibility, recovery and stability of the method were evaluated. The method has been successfully applied to preclinical pharmacokinetic study of Irinotecan liposome
Quantitative Polymerase Chain Reaction (PCR) for Detection of Aquatic Animal Pathogens in a Diagnostic Laboratory Setting

Field: Veterinary (Health Sciences)

Abstract Real-time, or quantitative, polymerase chain reaction (qPCR) is quickly supplanting other molecular methods for detecting the nucleic acids of human and other animal pathogens owing to the speed and robustness of the technology. As the aquatic animal health community moves toward implementing national diagnostic testing schemes, it will need to evaluate how qPCR technology should be employed. This review outlines the basic principles of qPCR technology, considerations for assay development, standards and controls, assay performance, diagnostic validation, implementation in the diagnostic laboratory, and quality assurance and control measures. These factors are fundamental for ensuring the validity of qPCR assay results obtained in the diagnostic laboratory setting. Received March 30, 2011; accepted May 6, 2011