jimnoneill/paper-to-field-training huggingface dataset:
FIRST RESULTS OF REARING Solea senegalensis (KAUP, 1858) LARVAE USING A CO-FEEDING REGIME IN CANTABRIA (NORTHERN SPAIN)

Field: Agricultural and Biological Sciences (Life Sciences)

The present paper describes the first trials in Cantabria (northern Spain) on the larval growth and survival of Solea senegalensis (Kaup, 1858), involving co-feeding with live and inert feed, which could condition larvae to better accept a commercial diet. The larval growth rate, in terms of length and dry weight, was similar up to day 70. The average partial growth rates during different time intervals break down as 14.53 % from days 0-22; 7.4 % from days 22-43; and 4.76 % from days 43-70, with the first 22 days of growth clearly being the most important period. Some significant differences in length were found on days 26, 33, 39 and 43. The average survival rate was high (81 %) at day 70. Weaning trial began on day 80, when the larvae had reached a wet weight of approximately 100 mg. Previously, the larvae had been redistributed into two kinds of tanks: elongated S tanks (450 l, 3 m 2 ), and circular LE tanks (430 l, 1.54 m 2 ), stocked at a density of approximately 1 000-1 500 larvae/m 2 . At the end of weaning, significant differences were observed in length and wet weight between larvae weaned in the two kinds of tanks. In sum, these first results of breeding S. senegalensis in Cantabria, obtained at ambient temperature in a geographical setting different from the species’s native range, indicate that S. senegalensis has good prospects as an alternative species for the region’s aquaculture operations, since it is well accepted by consumers and enjoys a high market value.
Predicted and realized responses to selection for an index of bone length and body weight in Scottish Blackface sheep 1. Responses in the index and component traits

Field: Agricultural and Biological Sciences (Life Sciences)

ABSTRACT A selection experiment with Scottish Blackface sheep was used to compare predicted and realized responses to selection. Three closed lines, of approximate annual size of 270 ewes and 10 rams, were maintained between 1956 and 1974, in which selection was at random, or for high and low values of an index of cannon-bone length at 8 weeks of age adjusted for body weight at the same age. An unselected base flock (1954-55) and the randomly selected line were used to estimate base population parameters, while the selected lines were used to estimate realized responses to selection. Heritabilities and genetic correlations were obtained in the unselected lines from a variety of collateral and ancestral relationships. The important components of phenotypic variance were estimated and likely responses to selection predicted for the index and its two component traits. Realized responses to selection were estimated from the regression of response on selection differential. The expected variance-covariance matrix of observed responses was included in generalized least-squares estimates of these regressions. The realized heritability of the index under selection, estimated from the divergence of selected lines, was 0·52 (s.e. 0·02). After allowing for the expected reduction in heritability arising from linkage disequilibrium, this was very similar to the base population estimate of 0·56 (s.e. 0·04). The responses in the component traits of the index were also very close to those expected from base population parameters
Molecular basis of coiled-coil oligomerization-state specificity

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Coiled coils are extensively and successfully used nowadays to rationally design multistranded structures for applications, including basic research, biotechnology, nanotechnology, materials science, and medicine. The wide range of applications as well as the important functions these structures play in almost all biological processes highlight the need for a detailed understanding of the factors that control coiled-coil folding and oligomerization. Here, we address the important and unresolved question why the presence of particular oligomerization-state determinants within a coiled coil does frequently not correlate with its topology. We found an unexpected, general link between coiled-coil oligomerization-state specificity and trigger sequences, elements that are indispensable for coiled-coil formation. By using the archetype coiled-coil domain of the yeast transcriptional activator GCN4 as a model system, we show that well-established trimer-specific oligomerization-state determinants switch the peptide’s topology from a dimer to a trimer only when inserted into the trigger sequence. We successfully confirmed our results in two other, unrelated coiled-coil dimers, ATF1 and cortexillin-1. We furthermore show that multiple topology determinants can coexist in the same trigger sequence, revealing a delicate balance of the resulting oligomerization state by position-dependent forces. Our experimental results should significantly improve the prediction of the oligomerization state of coiled coils. They therefore should have major implications for the rational design of coiled coils and consequently many applications using these popular oligomerization domains.
Histopathologic Analysis of Sixteen Autopsy Cases of Chronic Hypersensitivity Pneumonitis and Comparison With Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia

Field: Medicine (Health Sciences)

Abstract Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by the inhalation of organic substances and certain inorganic chemicals. The histopathologic features of chronic HP (CHP) have not been studied extensively. We examined the pathologic characteristics of 16 autopsy cases of clinically confirmed CHP and compared them with 11 cases of idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP). To clarify the exact intralobular location of the fibrotic lesions, we conducted 3-dimensional reconstruction of fibrosis of CHP and IPF/UIP. Granuloma was not detected in any CHP case. Similar to IPF/UIP, honeycombing lesions were found dominantly in the lower lobes in most CHP cases; upper lobe dominance and asymmetrical distribution of honeycomb lesions were more frequent in CHP than in IPF/UIP. In all lungs affected by CHP, centrilobular fibrosis was outstanding, often connecting to the perilobular areas in the appearance of “bridging fibrosis,” which was clearly demonstrated by 3-dimensional imaging. Centrilobular and bridging fibrosis were significantly more conspicuous in CHP than IPF/UIP; however, considerable overlap was found. It is important to thoroughly explore the possibility of antigen exposure in cases of lungs with UIP with centrilobular fibrosis to discriminate CHP from IPF/UIP.
Cost-Efficient Hybrid Filter-Based Parameter Selection Scheme for Intrusion Detection System in IoT

Field: Computer Science (Physical Sciences)

The rapid growth of Internet of Things (IoT) devices has brought about significant advancements in automation, data collection, and connectivity across various domains. However, this increased interconnectedness also poses substantial security challenges, making IoT networks attractive targets for malicious actors. Intrusion detection systems (IDSs) play a vital role in protecting IoT environments from cyber threats, necessitating the development of sophisticated and effective NIDS solutions. This paper proposes an IDS that addresses the curse of dimensionality by eliminating redundant and highly correlated features, followed by a wrapper-based feature ranking to determine their importance. Additionally, the IDS incorporates cutting-edge image processing techniques to reconstruct data into images, which are further enhanced through a filtering process. Finally, a meta classifier, consisting of three base models, is employed for efficient and accurate intrusion detection. Simulation results using industry-standard datasets demonstrate that the hybrid parameter selection approach significantly reduces computational costs while maintaining reliability. Furthermore, the combination of image transformation and ensemble learning techniques achieves higher detection accuracy, further enhancing the effectiveness of the proposed IDS.
Aflatoxin Levels in Wheat Flour in Afar Region, Northeastern Ethiopia

Field: Agricultural and Biological Sciences (Life Sciences)

Aflatoxins are common contaminants in Agricultural commodities including wheat flour which pose a considerable risk to human health and have significant economic implications. The objective of this study was to determine the level of aflatoxin concentrations in wheat flour samplesat vendors and wholesalers from Logia-Samara, Dubti and Assaita town, Northeastern Ethiopia. A total of 60 flour samples were collected and analyzed for aflatoxin contamination using an ELISA test. Of the total 60 samples, aflatoxin was detected in 51, ranging from 1 ppb to 25 ppb. Aflatoxin concentrations were above 15 ppb in 65% of the positive samples collected from wholesalers in Assaita town. Moisture content and aflatoxin levels of flour samples were positively correlated (r = 0.917) and significant (p ≤ 0.05). This study identified heavy aflatoxin contamination in wheat flour beyond the maximum tolerable level by the CODEX (15 ppb). Therefore, the negative impacts of aflatoxin on health, and aflatoxin contamination should be considered in future programs. We suggest improvements be made to post-harvest management (proper drying, sorting, and storage) to reduce the level of aflatoxin contamination of wheat flour at vendors and wholesalers.
Influence of different pre-treatments and drying methods on the dry fractionation behavior of mealworm larvae (Tenebrio molitor)

Field: Agricultural and Biological Sciences (Life Sciences)

Ziel der Arbeit war es, den Einfluss von verschiedenen Trocknungsmethoden und Vorbehandlungen auf das trockene Fraktionierungsverhalten von Mehlwurmlarven zu untersuchen. Dazu wurden die Larven unter standardisierten Bedingungen getrocknet (Ofentrocknung, Gefriertrocknung und Wirbelschichttrockung), teilweise mit überkritischem CO2 entfettet und nach Vermahlung durch Siebung (0 – 1400 µm) fraktioniert. Diverse Analysen dieser Prozesse zeigen, dass eine erhöhte Trocknungstemperatur eine dunklere Farbe (Bräunungsreaktionen) und ein Schrumpfen der Larve (Gewebezerfall) zur Folge hatte. Hingegen wurde die Farbe der gefriergetrockneten und entfetteten Proben durch die Extraktion von Melanoidin aufgehellt. Eine Größenveränderung konnte nicht festgestellt werden. Je höher die Temperatur und Trocknungszeit, umso härter und kompakter wurde die Struktur der Larven bei der Heißlufttrocknung. Im Gegensatz dazu wiesen die gefriergetrockneten und entfetteten Proben eine porös-brüchige Textur auf. Dies hatte einen signifikanten Einfluss auf das Mahl- und Trennverhalten. 87 – 89 % (m/m) der heißluftgetrockneten und vermahlenen Larven hatten eine Partikelgröße über 500 µm; Gefriertrocknung 62 % (m/m), Entfettung 58 % (m/m). Dazu konnte eine Proteinanreicherung in kleineren Fraktionen (<500 µm) bei dem teilweise entfettetem Material (+5 % zur größten Fraktion) und der Wirbelschichttrocknung (+3 %) nachgewiesen werden. Chitin reicherte sich in größeren Fraktionen (>500 µm) an; besonders bei der Gefriertrocknung (+12,5 % zur kleinsten Fraktion), der Entfettung (+4,7 %) und der Wirbelschichttrocknung (+4,2 %). Entfettung und geringe Hitze führten zu einer gleichmäßigen Partikelgrößenverteilung und einer guten Trennbarkeit von Protein und Chitin. Die Heißlufttrocknung verursachte eine Partikelkonzentration im Bereich 500 – 1000 µm. Protein und Chitin konnten kaum getrennt werden, da dessen Bindung durch Hitzeeinwirkung zusätzlich verstärkt wurde.
Thermoelectric Properties of Sn2+-Substituted CuFeO2 Delafossite-Oxide

Field: Materials Science (Physical Sciences)

Abstract. This study aims to investigate the effect of the Sn2+-substituted into the CuFeO2 delafossite on thermoelectric properties in the Sn content of x = 0.03, 0.05. The CuFe1−xSnxO2 samples were synthesized by solid state reaction. The crystal structure was characterized by XRD, TGA, XPS and the thermoelectric properties were measured in the range of 300 to 960 K. The Seebeck coefficient display positive sign in all temperature range and the XPS show the stable Sn+2 state as confirming the Sn-doped CuFeO2 playing p-type conductor. The Sn 2+-substituted supports the mixed valency Fe3+/Fe4+ state in transition octahedral oxide of FeO6 layer enhancing Seebeck coefficient. The high Seebeck are appeared in content of x=0.03 which are 280 to 340 µV/K in the range of 300 to 800 K. The experimental Seebeck corresponds to the prediction formula at high temperature. Totally, the maximum Power Factor is 2.30×10−4 W/mK2 occurring in the CuFe0.95Sn0.05O2 at 860 K which is higher than that value of the undoped-CuFeO2 in 4 times. These support that the Sn-substituted CuFeO2 delafossite enhancing thermoelectric properties.
Macrolide total synthesis. The synthesis of seco-acid derivatives for the synthesis of methymycin and 10-deoxymethymycin

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMacrolide total synthesis. The synthesis of seco-acid derivatives for the synthesis of methymycin and 10-deoxymethymycinRobert E. Ireland, John P. Daub, Gretchen S. Mandel, and Neil S. MandelCite this: J. Org. Chem. 1983, 48, 8, 1312–1325Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://pubs.acs.org/doi/10.1021/jo00156a032https://doi.org/10.1021/jo00156a032research-articleACS PublicationsRequest reuse permissionsArticle Views450Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
An Improved Method of Transporting Donor Eyes

Field: Medicine (Health Sciences)

1965).This mixing of the two insulins in predetermined proportions is in our view most regrettable, since it deprives them of their only advantage, which is the appropriate adjust- ment of their individual dosage by the patient. SummaryTime-action studies of Actrapid and Crystal II insulins are reported.Actrapid insulin has a short action comparable to soluble insulin, and Crystal II insulin has an intermediate time-action.The method and results of their use over a period of one to two years are described in a group of 10 patients whose control was previously judged as unsatisfactory.We are indebted to Drs.
Joint Vessel Segmentation and Deformable Registration on Multi-Modal Retinal Images Based on Style Transfer

Field: Computer Science (Physical Sciences)

In multi-modal retinal image registration task, there are two major challenges, i.e., poor performance in finding correspondence due to inconsistent features, and lack of labeled data for training learning-based models. In this paper, we propose a joint vessel segmentation and deformable registration model based on CNN for this task, built under the framework of weakly supervised style transfer learning and perceptual loss. In vessel segmentation, a style loss guides the model to generate segmentation maps that look authentic, and helps transform images of different modalities into consistent representations. In deformable registration, a content loss helps find dense correspondence for multi-modal images based on their consistent representations, and improves the segmentation results simultaneously. Experiment results show that our model has better performance than other deformable registration methods in both quantitative and visual evaluations, and the segmentation results also help the rigid transformation 1 .
Friends in Our Lives: Perspectives of Young People Who Participated in a Professional Mentoring Program

Field: Social Sciences (Social Sciences)

Abstract Mentoring programs are popular interventions to support holistic development for young people. One specific model of mentoring that has emerged over the past few decades in the United States is professional mentoring. Research has illustrated that this model of mentoring may be particularly helpful for young people who could benefit from extra support in their lives that a volunteer mentoring program does not have the capacity to provide. Despite the emerging utilization of professional mentoring programs, little is known about the ideal characteristics of a professional mentor and young people’s experiences in these professional mentoring programs. This study interviewed 12 young people who participated in the same professional mentoring program in different regions of the United States. The participants discussed their ideal characteristics in a mentor, highlighted factors that made the professional mentoring program impactful to them, and shared their ideas on how to improve the overall program.
A Reliable Production System of Large Quantities of [13N]Ammonia for Multiple Human Injections

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

[13N]Ammonia is one of the most commonly used Positron Emission Tomography (PET) radiotracers in humans to assess myocardial perfusion and measure myocardial blood flow. Here, we report a reliable semi-automated process to manufacture large quantities of [13N]ammonia in high purity by proton-irradiation of a 10 mM aqueous ethanol solution using an in-target process under aseptic conditions. Our simplified production system is based on two syringe driver units and an in-line anion-exchange purification for up to three consecutive productions of ~30 GBq (~800 mCi) (radiochemical yield = 69 ± 3% n.d.c) per day. The total manufacturing time, including purification, sterile filtration, reformulation, and quality control (QC) analyses performed before batch release, is approximately 11 min from the End of Bombardment (EOB). The drug product complies with FDA/USP specifications and is supplied in a multidose vial allowing for two doses per patient, two patients per batch (4 doses/batch) on two separate PET scanners simultaneously. After four years of use, this production system has proved to be easy to operate and maintain at low costs. Over the last four years, more than 1000 patients have been imaged using this simplified procedure, demonstrating its reliability for the routine production of large quantities of current Good Manufacturing Practices (cGMP)-compliant [13N]ammonia for human use.
P & W 7704 60

Field: Arts and Humanities (Social Sciences)

NEW TEXAS PRIMARY READER. 59\nthing that is wrong, we should remember\nthat there is an eye above that sees all\nwe do.\nIf we feel inclined to leave our school,\nand waste our precious time in idleness or\nin mischief, we should repeat the four\nshort words—“ T h ou God s e e s t us,” and\nrefrain from sin.\nIf we are ever disposed to disobey our\ndear parents or teachers, and do those\nthings we know will displease them, may\nthe thought of the words, u T hou God\ns e e s t us,” keep us from doing the wrong\nwe are tempted to do.\nWhen we are excited to anger and the\nuse of wicked words, may we pause long\nenough to say, “ Thou God s e e s t us,”\nand we shall seldom indulge the angry\nlooks, or utter the wicked words. .\nWhen we are walking in the streets, or\nengaging in our sports, may the thought\nof the words, “ T h ou God s e e s t us,” keep\nus from every improper act and expres­sion.
[A new flavan-3-ol from Sargentodoxae Caulis].

Field: Chemistry (Physical Sciences)

Sargentodoxae Caulis was extracted with 80% ethanol and separated by macroporous resin, MCI, and ODS column chromatography and semi-preparative high performance liquid chromatography. The structures of the compounds were identified based on the NMR and MS data. A total of 19 compounds were identified as parabaroside D(1),(R)-2-(3,4-dihydroxyphenyl)-2-hydroxyethyl-O-β-D-glucopyranoside(2),(S)-2-(3,4-dihydroxyphenyl)-2-hydroxyethyl-O-β-D-glucopyranoside(3), protocatechin-3-O-β-D-glucoside(4), p-hydroxybenzoate-β-D-glucopyranoside(5), gentisic-5-O-β-D-glucopyranoside(6), vanillic acid 4-O-β-D-glucoside(7), syringic acid glucoside(8), uracil(9), uridine(10), neochlorogenic acid(11), chlorogenic acid(12), cryptochlorogenic acid(13), 3,4-dihydroxyphenylethanol glucoside(14), cuneataside A(15), cuneataside C(16), 4-hydroxy-3-methoxyacetophenone-4-O-β-D-apiose-(1→6)-β-D-glucopyranoside(17), proanthocyanidin B2(18), and baimantuoluoamide B(19). Compound 1 was a new flavan-3-ol, and compounds 2, 3, 5, 6, 9, and 19 were isolated from this plant for the first time. Compounds 2 and 3 were a pair of epimers. Compound 14 had the highest anti-inflammatory activity.
The development of traditional wooden house using local coco wood waste as strategy for facing earthquakes

Field: Engineering (Physical Sciences)

Abstract The consideration of ecological quality is an approach for environmentally friendly house construction by utilizing waste material. This paper discusses a current study into developing local coco wood waste as an alternative construction material to build an earthquake-resistant wooden house. The aims of this research are 1) to identify the engineering properties and strength classification of local coco wood; 2) to design and analyse the structural elements for a traditional wooden house through a seismic approach; and 3) to demonstrate the construction method of a coconut timber house prototype. Research methods include 1) laboratory testing of the physical and mechanical properties comprising density test, compression test parallel to the grain, and flexural test. All tests were performed according to the American Standard Testing Material (ASTM) D143-09; 2) identification of strength classification of coco wood based on SNI 03-3527-1994; 3) design of the structural components and analyse structural performance using ETABS simulation; and 4) construction of a prototype earthquake-resistant coconut-timber house. Results from this research are expected to support the beneficial usage of local coco wood waste as a construction material for timber houses in an effort to mitigate the risk of earthquake hazard.