jimnoneill/paper-to-field-training huggingface dataset:
Natural Products in the Fight Against Multi-Drug-Resistant Bacteria

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

It is well recognised that the antimicrobial resistance crisis has approached critical levels, and current treatment options are very limited, especially in the treatment of infections caused by resistant bacteria. Thus, ongoing research is focused on the development of new molecules which have broader antimicrobial activity. However, the advancements in drug development studies using synthetic compounds has led to a lack of success. Also, economic and regulatory issues have formed a challenge as well. Therefore, research has focused again on natural products. A large number of natural products and natural product-derived compounds are still in various stages of clinical development. Here, current research on the potential uses of natural products or their templates as viable sources of new drug candidates have been discussed to construct an understanding towards the goal of development of new antimicrobials to overcome resistant pathogens.
Development and external validation of a dynamic nomogram for delayed cerebral ischaemia after aneurysmal subarachnoid hemorrhage: a study protocol for a multicentre retrospective cohort study

Field: Medicine (Health Sciences)

Introduction Delayed cerebral ischaemia (DCI) caused by aneurysmal subarachnoid haemorrhage (aSAH) is the most frequent complication and typically contributes to poor neurological outcome or deterioration of patients’ condition. Therefore, early accurate and effective prediction of DCI is urgently needed. This study aims to construct a dynamic nomogram for precisely calculating the risk of DCI in patients with aSAH. Internal validation of this tool is conducted using the training cohort, and independent external validation is completed by using other medical centre datasets. Methods and analysis This study is a multicentre, retrospective, observational cohort study using data from patients with aSAH. The participants include all adult patients who received surgical treatment in neurosurgery of multiple medical centres from 1 September 2019 to 1 April 2021, including Renmin Hospital of Wuhan University, Huzhou Central Hospital, First Affiliated Hospital of Harbin Medical University, General Hospital of Northern Theatre Command and Affiliated Hospital of Panzhihua University. Clinical information is collected via the electronic medical record system, including demographic data, clinical state on admission and serum laboratory tests. Modified Fisher grade at admission, admission subarachnoid clot and cerebral oedema density, and residual postoperative subarachnoid clot density are determined using the electronic imagine record software. The primary outcome is DCI. Ethics and dissemination This study protocol was reviewed and approved by the Medical Ethics Committee of Renmin Hospital of Wuhan University, which is the principal affiliation of this study (approval number: WDRM2021-K022). The other Ethics Committees, including Huzhou Central Hospital (approval number: 202108005–01), First Affiliated Hospital of Harbin Medical University (approval number: H202156), General Hospital of Northern Theater Command (approval number: Y2021060) and Affiliated Hospital of Panzhihua University (approval number: 202105002), also approved the protocol. The results of this research will be published in a peer-reviewed medical journal. Trial registration number ChiCTR2100044448.
https://dumpsboss.com/microsoft-exam/mb-300/

Field: Business, Management and Accounting (Social Sciences)

Now in advance than you buy our MB-3 hundred real questions dumps, we want to installation a dating of receive as genuine with with you. We need to offer Microsoft Dynamics 365 MB-3 hundred test dumps unfastened direction demo that consists of all the test questions of MB-3 hundred Microsoft Dynamics 365 Unified Operations Core exam. You can go through the Microsoft MB-3 hundred dumps pdf files for better information the volume MB-300 Dumps and status of our MB-3 hundred exercising dumps. Once you are satisfied with that, you could buy our Microsoft MB-3 hundred questions dumps in your MB-3 hundred Microsoft Dynamics 365 Unified Operations Core exam education with the right questions and answers. Moreover, collectively at the side of your Microsoft Dynamics 365 MB-3 hundred pdf dumps purchase, you may get a three month unfastened updates on Microsoft MB-3 hundred exercising questions.\n\nhttps://dumpsboss.com/microsoft-exam/mb-300/\n\nhttps://sites.google.com/view/bestexamsdumpsite/mb-300-dumps
Toward Integrally Informed Theories of Transformative Learning

Field: Arts and Humanities (Social Sciences)

This article investigates possibilities for advancing beyond the shortcomings of deconstructive postmodern perspectives shaping transformative learning (TL) theory. The author introduces Ken Wilber's integral metatheory and explores four recommendations to inspire future “integrally informed” theories of TL. Intending to supplement existing integrative, holistic, and integral perspectives within the literature, this article also raises a number of questions to invite other scholar-practitioners to contemplate how we might proceed with building frameworks of TL theory that are more comprehensive, balanced, and inclusive.
Fig. 22 in Taxonomic revision of the genus Loboscelidia Westwood, 1874 (Hymenoptera: Chrysididae: Loboscelidiinae) from Vietnam

Field: Agricultural and Biological Sciences (Life Sciences)

Fig. 22. Loboscelidia squamosa sp. nov., holotype, ♀ (VNMN). A. Lateral habitus. B. Head, dorsal view. C. Head, frontal view. D. Head, lateral view. E. Forewing. F. Pronotum, dorsal view. G. Mesosoma, dorsal view. Scale bars = 0.5 mm.
ОСОБЛИВОСТІ ФОРМУВАННЯ ПРОЕКТІВ: ФУНКЦІЇ, ЕТАПИ, СКЛАДОВІ

Field: Business, Management and Accounting (Social Sciences)

The article addresses the topic of project formation, under modern conditions of project management. The authors, using the study of popular thoughts on this topic, tried to construct an integration model of the project components. The article provides the systematization and analysis of functions, stages and components of project formation in modern conditions of project management. The functions of project formation that were considered include functions such as initiation and planning, which from the author’s point of view should be attributed to the statutory documented component of the project, and functions of implementation, analysis, management, completion and corresponding to them stages and components. Innovative and marketing components were identified to make the project adapt to modern market conditions. As well as subcomponents of the organizational component, such as change management and change control, risk management, resource and schedule management and documentation management. Highlighted the importance of project objectives to correspond with the principles of SMART: to be specific, measurable, attainable, relevant and time bound. The paper notes that the process, financial and organizational components must be placed at the same level to remain relevant in today’s market. Definitions of project stages are given. Were pointed out the difference between the mission and the goal of the project and the importance of distinguishing the components of the project so that they interact organically with each other. According to the results of the study, it was concluded that for the success of a modern project it is necessary to have an integration model of the project components, so its components must integrate with each other. It is also stated that it is necessary to spend more time on structuring the risks of the project, on the importance of sufficient detailing of the project components, not to split up them too much and enlarge the components for the successful formation and implementation of the project.
Annual juvenile recruitment of spiny lobsters, Panulirus argus (Decapoda, Palinuridae), in a shallow seagrass bed and a deeper hard bottom off western Puerto Rico

Field: Agricultural and Biological Sciences (Life Sciences)

We found 158 juvenile Caribbean spiny lobsters ( Panulirus argus ) recruiting over a year into 10 artificial shelters in shallow (2-3 m) seagrass beds, but none recruiting into 10 shelters on deeper (approximately 10 m) hard bottom. Spiny lobster juveniles were observed at 10 m or greater depth in submerged fish cages. They may have been strained out by currents rather than naturally recruiting. A large number of these cages inshore could impede natural lobster recruitment. One of the shallow shelters recruited most (85/158) of the juveniles and two shelters recruited most of all (118/158). With no discernable natural habitat difference, we assume that early recruitment into those shelters and the “guide effect” may have been responsible for these preferences. Previous Caribbean studies found the maximum settling periods of juveniles in August to December. Our results were similar with the exception of having more recruits one month later (August to January). Shelters with covers had more juveniles than those without covers; however, this result was largely due to the preponderance of juveniles in one shelter.
Netrins in glioma biology: regulators of tumor cell proliferation, motility and stemness

Field: Medicine (Health Sciences)

Glioblastoma is the most malignant brain cancer. Currently no cure has been established. The lethality of glioblastoma is a consequence of its extremely invasive nature: it rarely metastasizes outside the nervous system but effectively spreads throughout the brain parenchyma. This property, in addition to its challenging location makes it impossible to remove surgically. Furthermore, the tumors are heterogeneous and contain cells that are resistant to radiation therapy as well as to the only currently approved chemotherapy, temozolomide. \n\nNetrins are secreted extracellular matrix proteins. They were initially identified as proteins essential for the correct axonal wiring of both vertebrates and invertebrates. Later, they were observed to regulate the branching morphogenesis of various organs including mammary gland, lungs and pancreas. During recent years increasing number of studies have linked netrins to various forms of cancer. For example, netrin-1 induces the invasion of pancreatic, colorectal and hepatocytic cancers and medulloblastoma and promotes the survival of breast and lung cancer and neuroblastoma. Netrin-4 can modulate tumor growth, angiogenesis and metastasis. \n\nIn the current work, we analyzed how netrins contribute to glioblastoma growth. We discovered that both netrin-1 and -4 regulate the malignancy of glioblastoma via independent pathways. Netrin-1 expression was upregulated in glioblastoma whereas netrin-4 was downregulated. However, both were associated with poor patient prognosis. The signaling pathways mediating the effects of these proteins were systematically explored. \n\nFirst, our results revealed a new mechanism where netrin-4 controls glioma cell proliferation via UNC5B and ITGB4 receptors. During normal cell culture conditions netrin-4 is abundantly expressed, and it binds to both UNC5B and ITGB4 receptors that counteract each other and keep glioma cell proliferation in balance. However, during glioma progression netrin-4 expression is decreased and the signaling is shifted towards ITGB4. This led to increased cell proliferation and tumor growth. \n\nSecond, we discovered a mechanism through which netrin-1 promotes cell invasion. Netrin-1 expression associated with astrocytomas which are invasive glioma subtype. In glioblastoma cells it interacted with Notch2 and Jagged1 and facilitated the activation of the signaling. Subsequently, this led to an increase in cell invasion in vitro and in vivo. Furthermore, a unique invasion pattern was characterized where netrin-1 expressing cells were promoting the motility and stemness of the invasion leading stem-like cells. \n\nThird, we designed and engineered a recombinant peptide that had the capacity to inhibit netrin-1 signaling. This peptide was able to overcome the effects of the full-length netrin-1 and specifically inhibited the invasiveness of the stem-like glioblastoma cells in vitro and in vivo. This peptide may prove out to be of therapeutic value in GBM treatment.
Did Dad Lick the Kids Today? Transmission of Microbes Through Parental Care in a Teleost Fish (Archocentrus nigrofaciatus)

Field: Agricultural and Biological Sciences (Life Sciences)

Males and females may make distinctly different contributions to parental care. In cichlid fishes, females typically care for embryos while males guard territories. Parent-offspring contact may enhance transmission of beneficial microbes. Microbial sharing between group members is a potential mechanism for the evolution of social behavior (Lombardo 2007). Parental care is unusual among teleost (bony) fishes, but is ubiquitous among the cichlid fishes, and convict cichlids (Archocentrus nigrofaciatus) exhibit biparental care. We (1) quantified the parental behavior of males and females to determine whether they differed in amount or type of physical contact with their offspring; (2) collected samples of parental slime coats, embryos, and fry to compare the microbes associated with each, comparing samples from subsets of broods receiving parental care to others where parental contact was prevented. Females touched embryos significantly more often than males, but physical contact with fry is much less common and initiated by fry rather than parents. To date, molecular data support our prediction that fry receiving parental care bear microbes more similar to female vs. male parents, and to parents vs. siblings that did not receive care. Assuming this trend continues in subsequent samples, we conclude that parents are an important source of microbial inocula and that female contact during immobile developmental stages is especially important for microbial transmission.
Aliphatic polyamine ruthenium(II) complexes: crystal structure, DNA-binding, photocleavage, cytotoxicity, and antioxidation

Field: Chemistry (Physical Sciences)

The DNA-binding behaviors of two aliphatic polyamine Ru(II) complexes, [Ru(dppt)(dien)](ClO4)2 (1) and [Ru(pta)(dien)](ClO4)2 (2) (dppt, pta, and dien standing for 3-(1,10-phenanthrolin-2-yl)-5,6-diphenyl-as-triazine, 3-(1,10-phenanthrolin-2-yl)-5,6-diphenyl-as-triazino[5,6-f]-acenaphthylene, and diethylenetriamine, respectively), were studied through absorption titration, thermal denaturation, and viscosity measurements. The results indicate that the DNA-binding affinity of 2 is much greater than that of 1; 2 binds to CT-DNA in an intercalative mode but 1 binds to CT-DNA through partial intercalation. In addition, the complexes react with DNA in an energy-driven process with a decrease in entropy. The photocleavage of plasmid pBR322 can be triggered by 1 and 2 and strengthened with an increased concentration of both complexes. The scavenging activity of 1 against hydroxyl radical (˙OH) is slightly better than that of 2 according to the antioxidation experiment. The standard cytotoxicity experiments were carried out with MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide); the results indicate that the proliferation of Hela, A549, and 7402 cells is inhibited by these two compounds in a dose-dependent manner. The X-ray crystal structure of 1 and some results of DFT (the density functional theory) calculations were analyzed to further understand the differences in DNA-binding strength of the complexes.
Dissensus and ‘shimmering’

Field: Arts and Humanities (Social Sciences)

This chapter examines several phenomena in contemporary Russian art that seem to intentionally undermine or betray the very discourses that they claim to voice. It argues that these betrayals are a strategic effort towards a redistribution of the sensible, motivated by a deep scepticism about the prospects of overturning oppressive social institutions without replacing them with something equally odious. The chapter traces this effort to the counter-ideological strategy known as 'shimmering' (mertsatelnost or mertsanie) in the discourse of the Moscow Conceptualists, among whom the poet and artist Dmitrii Prigov, who coined the term 'shimmering' in the late 1970s, was a key figure. Politics manifests 'dissensus', the break within the whole, challenging the unity of the social totality that the 'police' seek to embody. The opposition between Russian Nonconformist art of the 1960s and Socialist Realism aptly represents Ranciere's terms in action. The chapter examines the afterlife of Moscow Conceptualism through several indirect examples from post-Soviet and contemporary Russian art.
Effects of Methylene Blue on Intestinal Perfusion and Oxygenation in Dogs With Septic Shock

Field: Veterinary (Health Sciences)

Objective To study the effects of methylene blue(MB), a soluble guanylate cyclase inhibitor , on intestinal perfusion and oxygenation in dogs with septic shock.Methods A septic shock model was established by lipopolysaccharide infusion.After resuscitation with normal saline infusion,2mg/kg MB was infused within 15min in seven dogs.Blood flow of the superior mesenteric artery (SMA) was measured respectively at baseline,post shock for 1h, after resuscitation and 30min after MB injection.Blood gas analysis was done , and oxygenation was calculated.Results Blood flow of the SMA was significantly decreased by 61 8%(P0 01) in dogs with septic shock ,oxygen delivery(DO 2) was decreased by 62 1%(P0 01) and oxygen extraction (O 2extr) was increased by 20 9%. When pulmonary artery wedge pressure reached a level of (12 1±1 4)mmHg with fluid resusciation , blood flow of the SMA was significantly increased by 54 6%(P0 01), DO 2 increased by 12 8%(P0 01) , and O 2extr increased by 23 5%.After MB infusion ,blood flow of the SMA was increased by 19 4%(P0 01).DO 2 kept unchanged(P 0 0 5 ) ,butO2 extrincreasedby 14 8% .Conclusions Septicshockindogsresultsinadecreaseinintestinalperfusionandanincreasein oxygenextraction ,whichcanbeimprovedbyMBinjection .Theintestinalperfusionispartlyincreasedbyvolumetherapy .
A study on marine cargo exposure due to natural hazards

Field: Business, Management and Accounting (Social Sciences)

This paper aims to understand and explain the following strange phenomenon that exists in the marine cargo insurance industry today: Marine cargo insurers are not adopting the usage of catastrophe modeling in their underwriting process, despite the substantial risks that natural catastrophes can pose to the sustainability of their insurance portfolio.This paper will then discuss the benefits of the implementation of catastrophe modeling into the risk assessment stage of underwriting. There are two main applications and benefits that this paper will analyze: 1. The usage of catastrophe modeling in rate-making and 2. The usage of catastrophe modeling in insurance portfolio management. Challenges pertaining to the implementation of catastrophe modeling within the realm of the marine cargo insurance industry will also be analyzed within this paper, along with a write-up of possible solutions with respect to these issues.
Challenges of Clinical Chemistry Analyzers Utilization in Public Hospital Laboratories of Selected Zones of Oromia Region, Ethiopia: A Mixed Methods Study

Field: Health Professions (Health Sciences)

Rebuma Belete1*, Waqtola Cheneke2, Aklilu Getachew2 and Ahmedmenewer Abdu1 Author Affiliations 1Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia 2School of Medical Laboratory Sciences, Faculty of Health Sciences, Institute of Health, Jimma University, Jimma, Ethiopia Received:March 16, 2021 | Published: March 22, 2021 Corresponding author: Rebuma Belete, Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia DOI: 10.26717/BJSTR.2021.34.005584
What are important consequences in children with non-specific spinal pain? A qualitative study of Danish children aged 9–12 years

Field: Medicine (Health Sciences)

Objectives It is currently unknown whether children, adolescents and adults experiencing non-specific spinal pain are affected by their pain in a similar manner. It is also unclear whether questionnaires developed for adults can simply be transferred to paediatric populations. The objective of this study was to explore the physical, psychological and social consequences of a life with non-specific spinal pain among Danish children and to compare these consequences with the content of common adult questionnaires. Design and setting A qualitative study based on individual interviews and focus group discussions with participants recruited from two public schools in Denmark. Participants Thirty-six children aged 9–12 years with spinal pain were invited to an interview using a purposive sampling strategy with age, pain intensity and frequency, and general well-being status as inclusion criteria. Nineteen (9 girls, 10 boys) accepted to participate. Methods Data were transcribed verbatim and coded by following a thematic approach to elicit key concepts relevant to spinal pain. Subsequently, focus group interviews were conducted, and all codes were assigned categories corresponding to the International Classification of Function, Disability and Health (ICF) for comparison to adult questionnaires. Results Nineteen interviews were included, and 21 individual codes identified. Across the codes, five themes emerged in relation to children’s experiences of living with spinal pain: ‘Sports and play’, ‘Axial loading’, ‘Coping strategies’, ‘Mood changes’ and ‘Pain anxiety’. Codes and themes were elaborated on by the focus groups. Only approximately 40% of the identified ICF categories were covered by adult spinal questionnaires. Conclusions The negative impact of non-specific spinal pain on children aged 9–12 years pivots around codes which are considerably different to adults. Psychological and social factors were more prominent and pain anxiety was dominant in the lived lives of children. New questionnaires should be age specific and include the identified codes within each theme.
ChemInform Abstract: Ruthenium Dioxide in a Fluoro Acid Medium. Part 3. Application to the Synthesis of Aporphinic, Homoaporphinic and Dibenzazocinic Alkaloids. Studies Towards the Preparation of Azafluoranthenic Skeleton.

Field: Chemistry (Physical Sciences)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.