jimnoneill/paper-to-field-training huggingface dataset:
Biochemical parameters of blood of broiler chickens when using probiotic normosil

Field: Agricultural and Biological Sciences (Life Sciences)

Experimental data are presented that the total protein in the I Experimental group, which consumed Normosil in the amount of 107 CFU, was 10.5% higher than the values of the control group, while the difference in the indicators in the IV Experimental group, in which the bird consumed a probiotic in a dose of 106 CFU with a break of 4 days after 10 days of giving over the control was 42.3% higher. At the same time, at the age of 40 days, the chickens of I Experimental Group sank in terms of both albumins and globulins. The glucose level in the experimental groups was higher by 6.2; 8.2; 32.0; 52.6% (p≤0.05), respectively. In terms of the amount of calcium at 35 days of age, the superiority of all chickens that consumed probiotics was by 18.61; 3.47; 8.83; 23.66% (p≤0.05), respectively, compared with the control group.
Cation Triggered Self-Assembly of α-Lactalbumin Nanotubes

Field: Chemistry (Physical Sciences)

Metal ions play a dual role in biological systems. Although they actively participate in vital life processes, they may contribute to protein aggregation and misfolding and thus contribute to development of diseases and other pathologies. In nanofabrication, metal ions mediate the formation of nanostructures with diverse properties. Here, we investigated the self-assembly of α-lactalbumin into nanotubes induced by coordination with metal ions, screened among the series Mn2+, Co2+, Ni2+, Zn2+, Cd2+, and Au3+. Our results revealed that the affinity of metal ions toward hydrolyzed α-lactalbumin peptides not only impacts the kinetics of nanotube formation but also influences their length and rigidity. These findings expand our understanding of supramolecular assembly processes in protein-based materials and pave the way for designing novel materials such as metallogels in biochip and biosensor applications.
Packaging Effects on Transistor Radiation Response

Field: Engineering (Physical Sciences)

A procedure is established for determining the effective device radiation dose from the equivalent silicon ionizing dose as measured by a silicon calorimeter, provided the incident spectrum and device dimensions are known. Experimental data is obtained from a silicon transistor packaged in Kovar and Kovar/ gold TO-5 cans and subjected to low-and high-energy photon radiation environments. The experimental results are compared to depth-dose profiles calculated by the SANDYL radiation transport code. The procedure correlates device photocurrent data between radiation environments with different photon energies.
Newly Qualified Primary Teachers: a comparative analysis of perceptions held by B.Ed. and PGCE trained teachers of their training routes

Field: Social Sciences (Social Sciences)

Abstract Two cohorts of newly qualified primary teachers (NQTs) beginning their careers in one LEA in England responded to two questionnaires which were designed to elicit their views about their preparation to meet the demands of their first post, their concerns about doing so and, 20 weeks into post, the nature of the demands they had experienced. The structure of the research sample allowed detailed comparative analyses to be made of the perceptions held by B.Ed. and PGCE trained teachers of their training routes and early experiences. Aspects of the training are identified which fall within the competency demands of Circular 14/93 on which NQTs feel underprepared. These represent areas where career entry support is required. Overall, students following the B.Ed. programme felt that they were better prepared than their PGCE counterparts. They also reported experiencing lower levels of stress.
Novel Polymorphic Microsatellite Loci for the Korean Black Scraper (Thamnaconus modestus), and Their Application to the Genetic Characterization of Wild and Farmed Populations

Field: Agricultural and Biological Sciences (Life Sciences)

In this study, we developed 20 polymorphic microsatellite markers for the Korean black scraper, Thamnaconus modestus (Günther, 1877), Monacanthidae, and used them to compare allelic variation between wild and hatchery populations in Korea. All loci were readily amplified and demonstrated allelic variability, with the number of alleles ranging from 5–35 in the wild population and 5–22 in the farmed population. The average observed and expected heterozygosities were estimated, respectively, as 0.74 and 0.80 in the hatchery samples and 0.78 and 0.81 in the wild ones. These results indicate lower genetic variability in the hatchery population than in the wild population and minor, but significant, genetic differentiation between the two populations (FST = 0.005, P < 0.01). Additionally, cross-amplification was tested in another monacanthid species, Stephanolepis cirrhifer; many loci were found that yielded useful information. The high degree of polymorphism exhibited by the 20 microsatellites will be useful in future aquaculture and population genetic studies for developing conservation and management plans.
Hepatoprotective Efficacy of Selegiline: Molecular Insight

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Liver fibrosis is a form of wound healing that develops in response to persistent liver injury brought on by viruses, poisons, and medicines that are harmful to the liver. Inflammation is a hallmark of the condition, which is then followed by the formation of scar tissue via the deposition of extracellular matrix proteins. Hepatitis C virus (HCV) entrance has been linked to the host cofactor ephrin receptor A2 (EphA2). Selegiline hydrochloride is a levorotatory acetylenic derivative of phenethylamine. It is commonly referred to in the clinical and pharmacological literature as l-deprenyl. Selegiline (deprenyl) is a selective inhibitor of cerebral monoamine oxidase type B at the dosage (10 mg/day) used in patients with Parkinson's disease. Through this activity, the drug increases nigrostriatal dopamine levels, and may protect neurons against damage by free radicals and possibly exogenous neurotoxins.The exact mechanism of action for the hepatoprotective action of Selegiline was still not revealed. With intent to propose the most probable mechanism of action of Selegiline the docking based computational analysis has been performed against the hepatoprotective drug targets like PPARα enzyme.
[The effect of contrast baths on the hemostatic function of patients with ischemic heart disease].

Field: Medicine (Health Sciences)

Contrast baths effects on hemostasis were studied in 72 patients with postinfarction cardiosclerosis and stable angina pectoris. Hemostasis was assessed by recalcification time, blood plasma tolerance to heparin, fibrinolytic activity, functional activity of antithrombin, soluble fibrin-monomeric complex, platelet count and aggregation. The results were compared to those in patients exposed to laser irradiation. Hydrotherapy with contrast baths was hemostatically effective in 70.9% of patients. Blood coagulation and platelet aggregation improved, the risk of intravascular microthrombogenesis diminished. Contrast baths had more pronounced beneficial effects on coagulation in ischemic heart disease of NYHA functional class II.
What might a partially relaxed anti-doping regime in professional cycling look like?

Field: Social Sciences (Social Sciences)

Cycling has a long and agitated relationship with doping. Despite important efforts, doping in cycling is ongoing. Frequent calls for more surveillance and repression suggest a goal justifies the means runaway dynamic. Since anti-doping already today comes with important even though mostly unintended side-effects, discussing alternatives for the current harsh anti-doping policy based on a 'zero-tolerance' stance is warranted. I here discuss what a partial relaxation of the anti-doping rule within a framework of harm-minimisation might look like. By keeping only the health risk criterion to forbid or limit the use of doping technology, anti-doping would become better aligned with the crux of elite athletic endeavour, i.e. the quest for performance enhancement, and developments of human enhancement in wider society.
Predicting Hospital Survival in Patients Admitted to ICU with Pulmonary Embolism

Field: Medicine (Health Sciences)

Objective The Pulmonary Embolism Severity Index (PESI) and simplified PESI (sPESI) predict mortality for patients with PE. We compared PESI/sPESI to the Acute Physiology and Chronic Health Evaluation IV (APACHE-IV) in predicting mortality in patients with PE admitted to the intensive care unit (ICU). Additionally, we assessed the performance of a novel ICU-sPESI score created by adding three clinical variables associated with acuity of PE presentation (intubation, confusion [altered mental status], use of vasoactive infusions) to sPESI. Materials and Methods Using the eICU Collaborative Research Database from 2014 to 2015, we conducted a large retrospective cohort study of adult patients admitted to the ICU with a primary diagnosis of PE. We calculated APACHE-IV, PESI, sPESI, and ICU-sPESI scores and compared their performance for predicting in-hospital mortality using area under the receiver operating characteristic (AUROC) curve. Score thresholds for >99% negative predictive values (NPV) were calculated for each score. Survival was estimated using the Kaplan–Meier method. Results We included 1424 PE cases. In-hospital mortality was 6.3% [95% CI: 5.1%-7.6%]. AUROC for APACHE-IV, PESI, and sPESI were 0.870, 0.848, and 0.777, respectively. APACHE-IV and PESI outperformed sPESI (P < 0.01 for both comparisons), while APACHE-IV and PESI demonstrated similar performance (P = 0.322). The ICU-sPESI performance was similar to APACHE-IV and PESI (AUROC = 0.847; AUROC comparison: APACHE-IV vs ICU-sPESI: P = 0.396; PESI vs ICU-sPESI: P = 0.945). Hospital mortality for ICU-sPESI scores 0-2 was 1.1%, and for scores 3, 4, 5, 6, and ≥7 was 8.6%, 11.7%, 29.2%, 37.5%, and 76.9%, respectively. Score thresholds for >99% NPV were ≤48 for APACHE-IV, ≤115 for PESI, and 0 points for sPESI and ICU-sPESI. Conclusions By accounting for severity of PE presentation, our newly proposed ICU-sPESI score provided improved PE mortality prediction compared to the original sPESI score and offered excellent discrimination of mortality risk.
A Monte Carlo method to compute the exchange coefficient in the double porosity model

Field: Mathematics (Physical Sciences)

The double porosity model allows to compute the pressure at a macroscopic scale in a fractured porous media, but requires the computation of some exchange coefficient characterizing the passage of the fluid from and to the porous media (the matrix) and the fractures. We propose a new Monte Carlo method to estimate this coefficient. Here we give an overview of Campillo et al [l, 2].
Multi-Class Kidney Abnormalities Detecting Novel System Through Computed Tomography

Field: Medicine (Health Sciences)

Impaired renal function poses a risk across all age groups. Because of the global shortage of nephrologists, the growing public health concern over renal failure, and technological improvements, there is a demand for an AI-driven system capable of autonomously detecting kidney abnormalities. Chronic kidney disease, commonly known as chronic renal failure, is characterized by a progressive decline in kidney function. Renal failure can be caused by a variety of reasons, including cysts, stones, and tumors. Chronic kidney disease may not have apparent symptoms at first, resulting in instances staying untreated until they reach an advanced state. Tumors are dense clumps of tissue that can cause direct injury to glands, spinal cells, and other organs. The presence of a substantial number of solids in the digestive tract causes kidney stone disease, also known as urolithiasis. This study used a deep learning model to detect kidney illnesses to solve the global scarcity of urologists. The project entailed obtaining and annotating a large dataset of 12,446 CT whole abdomen and urogram images, with an emphasis on kidney stones, cysts, and tumors, which are the most common types of renal illness. The dataset was divided into four categories: cyst, tumor, stone, and normal. Data was collected from several hospitals in the Dhaka area. This work presents an innovative and customizable platform for the clinical diagnosis of kidney diseases such as tumors, stones, and cysts. Our YOLOv8 model’s enhanced accuracy opens up new possibilities for identifying kidney cysts, stones, and tumors. We used criteria like accuracy, precision, recall, F1 score, and specificity to evaluate its performance. The network attained an accuracy rate of 82.52%, 85.76% precision, 75.28% recall, 75.72% F1 score, and 93.12% specificity.
The glucose - fructose ratio of California grapes

Field: Agricultural and Biological Sciences (Life Sciences)

• Because of the high sweetness of fructose table grape varieties of high fructose content would be of interest for cold climates. For producing stable sweet table wines with ordinary yeasts high fructose varieties would be desirable. With the Sauternes strain of yeast high glucose varieties would be favored. • The LOTHROP-HOLMES method gave good recovery of added glucose, duplicable results, and minor interference of fructose. • The glucose/fructose ratio of California grapes at maturity varies over a wide range, from at least 0.80 to 1.12. There is, however, considerable variability in the ratio between different vines. • Further data should be obtained for a large number of varieties in order to discover as wide a range of ratios as possible. Plant breeders could then use this information in their experiments.
Managing regional centres' of expertise collaborations with stakeholders including higher education institutions

Field: Social Sciences (Social Sciences)

Purpose – The purpose of this paper is to assist the United Nations Regional Centres of Expertise (RCEs) in continuing their fundamental work within the region and to address some of the prominent challenges within the RCE community. Specific RCE case studies from the global network were employed, emphasizing experiences in collaboration with multiple stakeholders including higher education institutions. Design/methodology/approach – Conducting a literature review and employing a qualitative research methodology with the use of a guided questionnaire, the paper aims to gain a deeper understanding of the operations of RCEs in general and more specifically the case studies. Findings – The paper shows some of the strategies implemented by the cohort of case studies to overcome their common challenges. Key recommendations based on the findings are made in its quest for continual development and final conclusions assessing the contentious challenges are drawn. Research limitations/implications – This paper focuses on RCEs within Europe, with cases from the USA and Canada for comparison. Although the paper highlights common themes and challenges, it is highly probable that RCEs outside of the studied regions may contend with similar challenges; further research would have to be conducted to assess the wider scope of the situation. Originality/value – The paper gives an external perspective of the challenges faced and identifies some areas in which improvements could be made. It is also generated from information gathered from multi-case study RCEs.
Table_5_Analysis of lncRNAs and mRNA Expression in the ZBTB1 Knockout Monoclonal EL4 Cell Line and Combined Analysis With miRNAs and circRNAs.xls

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>In previous experiments, we identified the effect of deletion of the Zbtb1 gene on circRNAs and microRNAs. In this study, we examined the expression profiles of lncRNAs and mRNAs using the RNA-seq method for Zbtb1-deficient EL4 cells and performed a clustering analysis of differentially expressed lncRNAs and mRNAs. GO term histograms and KEGG scatter plots were drawn. For the experimental results, a joint analysis was performed, which predicted the regulatory relationships among lncRNAs, mRNAs, microRNAs and circRNAs. For the regulatory relationship between lncRNAs and target genes, the chromatin structure and the degree of openness were verified for the possible target gene locations regulated by lncRNA using experimental methods such as Hi-C and ATAC-seq. Ultimately, the possible differential regulation of the Brcal and Dennd5d genes by lncRNAs and the differential changes in transcription factor binding sites in the promoter region were identified. For neRNA-regulated target genes with significantly differentially expressed mRNAs, a combined screen was performed, and the final obtained candidate target genes were subjected to GO and KEGG term enrichment analyses. Our results illustrate that the Zbtb1 gene can not only function as a regulatory factor but also regulate EL4 cells from multiple perspectives based on ceRNA theory.</p>
[Nursing in primary care in Mexico].

Field: Nursing (Health Sciences)

In keeping with the global goal of health for all, the National Development Plan of Mexico describes health as a social right. To give effect to this right it is felt that the health sector must be restructured so as, among other purposes, to improve the coverage of services and strengthen the coordination of education institutions and social security agencies with health establishments, and to make the training of health personnel responsive to the country's real needs. No profession is better suited than nursing to the diversity of tasks in primary care. The authors describe the key role of this personnel in extending the coverage of health services to the entire population. They enumerate the range of basic--technical, administrative and educational--functions performed by nurses, and some factors that reinforce and others that restrict the contribution of nursing to primary health care in Mexico.
PERANCANGAN SISTEM PENELUSURAN ALUMNI (TRACER STUDY) BERBASIS WEB

Field: Computer Science (Physical Sciences)

Kualitas lulusan perguruan tinggi ditentukan oleh proses pendidikan yang diselenggarakan program studi dalam mencetak kader-kader intelektual. Karakter lulusan yang baik dibangun dengan proses yang baik oleh program studi bila semua stake holder terlibat dengan tujuan sama membentuk proses pembelajaran pendidikan program studi yang baik. Proses pembelajaran pendidikan dikatakan baik apabila lulusannya dibutuhkan oleh pengguna lulusan, sehingga untuk mencapai taraf tersebut program studi harus tahu keinginan pengguna lulusan dengan melibatkan peran alumni sebagai sumber infomasi. Kontribusi alumni yang baik terhadap sumbangan pemikiran dan finansial kepada program studi akan mempengaruhi perkembangan perguruan tinggi. Penelitian dilaksanakan untuk membangun sistem informasi alumni teknik industri agar membantu pelacakan alumni, melalui tahapan pertimbangan faktor-faktor dalam merancang sistem informasi alumni, mengumpulkan data kebutuhan dan keinginan stakeholders. Hasil penelitian menunjukkan bahwa strategi untuk rancangan sistem informasi alumni harus mempertimbangkan aspek-aspek database, jaringan internet, hosting, coding, dan desain sehingga tampilan sistem informasi dapat menarik stakeholders
Phenotyping of a winter barley diversity panel of above and below ground traits

Field: Agricultural and Biological Sciences (Life Sciences)

Der Anbau von Wintergerste (Hordeum vulgare L.) hat in Österreich in den letzten Jahren zugenommen, da so die Winterfeuchte genutzt und der mit dem Klimawandel zunehmenden Sommerhitze ausgewichen wird. Der Wurzelwinkel als Hauptmerkmal der Wurzelarchitektur gibt Aufschluss über die unterirdische Anpassung der Gerste, was angesichts der zunehmenden Trockenperioden von besonderem Interesse ist. Dabei sind auch die agromorphologischen Eigenschaften für die Züchter von großer Bedeutung. Ziel war es, 200 Wintergerstengenotypen aus dem europäischen und dem ICARDA-Genpool auf ihre Ertragseigenschaften, den Wurzelwinkel sowie deren Zusammenspiel zu untersuchen. Die Beziehungen wurden durch Korrelationsrechnungen untersucht und zeigten für den Wurzelwinkel nur schwache positive Korrelationen mit dem Stroh- und Biomasseertrag. Die Kornbreite hatte im Vergleich zu anderen Kornmerkmalen den größten Einfluss auf den Ertrag und das Tausendkorngewicht. Für die Bodenbedeckung konnte kein Zusammenhang mit der Saatstärke gefunden werden, stattdessen hatte die Geschwindigkeit der Pflanzenentwicklung einen deutlich größeren Einfluss. Die Unterschiede zwischen den Herkünften und Zuchtstatus wurden identifiziert und eine Hauptkomponentenanalyse (PCA) durchgeführt. Die Ergebnisse zeigten signifikante Unterschiede zwischen Zuchtstatus und Herkunft für alle Merkmale mit Ausnahme des Wurzelwinkels. Die europäischen Sorten wiesen den höchsten Kornertrag und das größte Tausendkorngewicht auf, während die europäischen Zuchtlinien ein signifikant höheres Hektolitergewicht aufwiesen. Die zweizeiligen europäischen Sorten und Zuchtlinien unterschieden sich am deutlichsten von den anderen in der PCA. Vergleicht man nur die Zeiligkeitstypen, wurden kaum Unterschiede in der Merkmalsausprägung festgestellt. Die erlangten Informationen werden in Zukunft bei der Auswahl geeigneter Genotypen für Zuchtprogramme hilfreich sein. Neue Erkenntnisse konnten auch über die Rolle des Wurzelwinkels gewonnen werden.
Comprehensive analysis of competitive endogenous RNAs network: Identification and validation of prediction model composed of mRNA signature and miRNA signature in gastric cancer

Field: Medicine (Health Sciences)

Gastric cancer (GC), one of the most lethal malignant tumors, is highly aggressive with a poor prognosis, while the molecular mechanisms underlying it remain largely unknown. Although advanced imaging techniques and comprehensive treatment facilitate the diagnosis and survival of some GC patients, the precise diagnosis and prognosis are still a challenge. The present study used publicly available gene expression profiles from The Cancer Genome Atlas and Gene Expression Omnibus datasets including mRNA, micro (mi)RNA and circular (circ)RNA of GC to establish a competing endogenous RNA network (ceRNA). Further, the present study performed least absolute shrinkage and selector operator regression analysis on the hub RNAs to establish a prediction model with mRNA and miRNA. The ceRNA network contained 109 edges and 56 nodes and the visible network contains 13 miRNAs, 9 circRNAs and 34 mRNAs. The five mRNA-based signature were CTF1, FKBP5, RNF128, GSTM2 and ADAMTS1. The area under curve (AUC) value of the diagnosis training cohort was 0.9975. The prognosis of the high-risk group (RiskScore >4.664) was worse compared with that of the low-risk group (RiskScore ≤4.664; P<0.05) in the training cohort. The five miRNA-based signature were miR-145-5p, miR-615-3p, miR-6507-5p, miR-937-3p and miR-99a-3p. The AUC value of the diagnosis training cohort was 0.9975. The prognosis of the high-risk group (RiskScore >1.621) was worse compared with that of the low-risk group (RiskScore ≤1.621; P<0.05) in the training cohort. The validation cohorts indicated that both five mRNA and five miRNA-based signatures had strong predictive power in diagnosis and prognosis for GC. In conclusion, a ceRNA network was established for GC and a five mRNA-based signature and a five miRNA-based signature was identified that enabled diagnosis and prognosis of GC by assigning patient to a high-risk group or low-risk group.