jimnoneill/paper-to-field-training huggingface dataset:
In silico bioprospecting of antiviral compounds from marine fungi and mushroom for rapid development of nutraceuticals against SARS-CoV-2

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) affects human respiratory function that causes COVID-19 disease. COVID-19 has spread rapidly all over the world and became a pandemic within no time. Therefore, it is the need of hour to screen potential lead candidates from natural resources like edible mushrooms and marine fungi. These natural resources are very less explored till now and known to be the source for many medicinal compounds with several health benefits. These medicinal compounds can be easily exploited for the faster development of nutraceuticals for controlling SARS-CoV-2 infections. Our Insilico research suggests, bioactive compounds originating from mushroom and marine fungi shows strong potential to interact with ACE2 receptor or main protease of SARS-CoV-2, showing the inhibition activity towards the enzymatic protease. We performed a series of Insilico studies for the validation of our results, which includes Molecular docking, drug likeness property investigation by Swiss ADME tools, MD simulation, and thermodynamically stable free binding energy calculation. Overall, these results suggest that Ganodermadiol and Heliantriol F bioactive compounds originating from edible mushroom has strong potential to be developed as low-cost nutraceutical against SARS-CoV-2 viral infection. The drug candidate isolated from marine fungi and edible mushroom are highly unexplored for the development of potential alternative drug against SARS-CoV-2 virus with minimum side effects. Though our in silico studies of these compounds are showing a promising results against SARS-CoV-2 main protease and ACE2 receptor binding domain, the effectiveness of these bioactive compounds should be further validated by proper clinical trials. Communicated by Ramaswamy H. Sarma
Comparison of oral human papilloma virus detection methods among Hispanic adults

Field: Medicine (Health Sciences)

Abstract Objectives Oral human papilloma virus (HPV) infection is associated with nearly three‐quarters of all oropharyngeal cancers in the United States. Research also suggests its association with periodontal disease. There are limited studies evaluating differences in HPV detection methods; however, oral rinse is considered the most sensitive detection method. We compared HPV detection by self‐collected oral rinse versus self‐collected cytobrush and assessed whether the strength of association between periodontitis and HPV is modified by the collection method. Materials and Methods Data from a cross‐sectional study of Hispanic adults in Puerto Rico ( n = 346) who provided oral rinse and cytobrush samples for oral HPV detection and were clinically evaluated for periodontitis. The agreement between the oral mouthwash and cytobrush methods was assessed using the Kappa ( κ ) statistic. Logistic regression models were used to determine if the association between HPV infection and other risk factors varied by oral sample collection method. Results HPV prevalence was slightly higher using cytobrush than oral rinse (5.8% vs. 4.3%). The sensitivity of cytobrush to detect oral HPV was 64.7%, and the specificity was 97.4%. We observed a κ of 0.61 (95% confidence interval [CI]: 0.45–0.78), indicative of fair to good agreement between the two collection methods. The association between oral HPV infection and periodontitis severity was stronger when using the oral rinse collection method (odds ratio [OR] = 3.23, 95% CI: 1.06–9.84); the association was not statistically significant for cytobrush (OR = 1.96, 95% CI: 0.68–5.65). Conclusions These findings support the significance of choosing the most suitable collection method in oral HPV‐related studies. Selecting the most appropriate collection method is an essential criterion in oral HPV‐related studies.
Effect of Support Geometry on Catalytic Activity of Pt/CeO2Nanorods in Water Gas Shift Reaction

Field: Chemical Engineering (Physical Sciences)

Nanorod and particle shape $CeO_2$ were synthesized via hydrothermal process and precipitation method, respectively, and used as supports of Pt catalyst for water gas shift (WGS) reaction. Three different durations (12, 48, and 96h) for hydrothermal process were applied for the preparation of nanorod type $CeO_2$. 1.0 wt% of Pt was loaded on the prepared supports with incipient wetness method prior to the catalytic activity tests that were carried out at a GHSV of $95,541h^{-1}$, and a temperature range of 200 to $360^{\circ}C$. Varying duration of hydrothermal process led to the difference in physical characteristics of $CeO_2$ nanorods, such as aspect ratio, BET surface area, pore diameter, and pore volume. Consequently, the catalytic activities of Pt/$CeO_2$ nanorods were affected by the physical characteristics of the supports and appeared to be in the order of Pt/$CeO_2$(12) > Pt/$CeO_2$(48) > Pt/$CeO_2$(96). The comparison of the catalytic activities and results of the analysis (XPS, XRD, SEM, BET and TPR) for the supports revealed that the activity of the catalysts depends on chemical states of the Pt and the support materials in the temperature range that is lower than $280^{\circ}C$. However, the activity is rather dependent on the physical characteristic of the supports because the increased gas velocity limits the mass transfer of reactants in micropores of the supports.
Hypothesis Discrimination with Abstractions based on Observation and Action Costs

Field: Computer Science (Physical Sciences)

Several explanation and interpretation tasks, such as diagnosis, plan recognition and image interpretation, can be formalized as abductive and consistency reasoning. Some proposals address the problem based on a task-independent representation of a domain which includes an ontology or taxonomy of hypotheses. In this paper we rely on the same type of representation, and we address cost tradeoffs in abduction intended as an iterative process where, like in model-based diagnosis, further observations are proposed to discriminate among candidates. Discrimination is performed up to an appropriate level which depends on the cost of actions (e.g. repair actions or therapy) to be taken based on the results of abduction, and on the cost of additional observations, which should be balanced with the benefits, in terms of more suitable actions, of better discrimination. Abstractions have a significant impact on this trade-off, given that the cost of observing the same phenomenon at different levels of abstraction may be quite different.
Integrating NLP with Reasoning about Actions for Autonomous Agents Communicating with Humans.

Field: Computer Science (Physical Sciences)

Abstract—We present a first effort to integrate NLP with ASP for autonomous agents, especially service robots, communicating with humans. We implemented a prototype system and tested it in a simple home environment, which demonstrated the feasibility of our approach under current settings and the possibility that our approach will benefit from future advancement of research on NLP, ASP, and related areas. Keywords-Human-agent communication, NLP, Planning, ASP.
Optimal multiplexing of sampled signals on noisy channels

Field: Computer Science (Physical Sciences)

This paper deals with the joint optimization of transmitting and receiving filters in multiplex transmission of pulse-amplitude-modulated (PAM) signals. A mean-square-error criterion is used. The signal processes are assumed to be mutually uncorrelated and with equal power spectral densities. Transfer matrix functions for the transmitting and for the receiving filters are used as an expedient tool. It is shown that optimal multiplexing systems can be achieved with a bandwidth of M/T . The transfer matrix functions of optimal transmitters (and corresponding optimal receivers) are defined up to premultiplication by an arbitrary unitary matrix function. This provides for freedom of choice between various multiplexing techniques like frequency-domain multiplexing, time-domain multiplexing, or combinations thereof.
Distributed cognition in teams is influenced by type of task and nature of member interactions

Field: Psychology (Social Sciences)

In contemporary organizations, many—if not most—teams work on cognitive or information processing tasks (Hinsz, Tindale, &amp; Vollrath, 1997). The past 50 years of research have taught us much about how information is accessed, created, attended to, and processed as teams attempt to complete various tasks. However, many of the information processing effects that have been observed are task specific, yet little research has focused specifically on tasks and how their information processing requirements differ. In this chapter, we discuss how task differences can impact how teams use and process information and how different information distribution patterns across members might impact performance. In addition, we address how constraints on the amount and type of interactions among the team members influences performance in different task domains. We hope our discussion demonstrates the importance of task differences for understanding team information processing and highlights where greater research focus will be fruitful.
Gestão da manutenção em equipamentos hospitalares: um estudo de caso

Field: Health Professions (Health Sciences)

Maintenance management in companies, whatever their branch of activity, has been a key factor in achieving the quality and reliability of the processes, this has made it invest more and more in tools that help in the continuous improvement of maintenance indicators. Therefore, the objective of this article is investigate the main causes of the high frequency of breakdown of hospital equipment and to demonstrate possible ways to treat them. For the analysis and study, quality tools and the observatory method were used in order to quantify the problems encountered with the high frequency of equipment breakdown and the costs generated with the repairs, and to elaborate proposals that could reduce them. With this, it was possible to perceive the points with greater failures and the elaboration of a plan of action with the purpose of to provide a significant improvement in the process of management of the hospital maintenance.
Analysts' Forecasts: Low‐Balling, Market Efficiency, and Insider Trading

Field: Economics, Econometrics and Finance (Social Sciences)

Abstract The phenomenon of low‐balling reported in the financial press involves downward biased projections of earnings by managers or analysts, thereby artificially lowering market expectations and creating a positive earnings surprise when actual earnings are announced. This study reports that the stock market does respond to such surprises relative to analysts' reported forecasts. Further, the proportion of insider buy‐transactions in the period prior to the earnings forecast is significantly higher for the sample with high positive earnings surprise than for the control sample with zero forecast errors. The study cannot distinguish whether managers or analysts are the source of the low‐balling and therefore makes no statement on the legality of such insider trades.
Learning the Art of Wholeness: Sri Aurobindo’s Philosophy of Education

Field: Arts and Humanities (Social Sciences)

A major part of the problem lies in our education lacking a soul dimension and striving for realization of wholeness as pedagogical methods lack a relation of love, mutuality, care and creativity among the partners and fellow travellers and educational objectives lack the goal of integral development of individuals and societies. In integral education, art, songs, painting, music and drama play a pivotal role in the education of the vital. But education as learning the art of wholeness calls for transformation of our prevalent vision and practice of human development, especially child development. Education as learning the art of wholeness does not dismiss science and technology, rather it strives for a new integration in which art, science and technology become part of ever-widening interpenetrative circles of realization. But education as learning the art of wholeness is not just confined to a select few as is the case with all initiatives in alternative education.
CAD/CAM-produced surgical guides: Optimizing the treatment workflow.

Field: Dentistry (Health Sciences)

The increased availability of devices for 3D radiological diagnosis allows the more frequent use of CAD/CAM-produced surgical guides for implant placement. The conventional workflow requires a complex logistic chain which is time-consuming and costly. In a pilot study, the workflow of directly milled surgical guides was evaluated. These surgical guides were designed based on the fusion of an optical impression and the radiological data. The clinical use showed that the surgical guides could be accurately placed on the residual dentition without tipping movements. The conventional surgical guides were used as a control for the manual check of the deviation of the implant axis. The direct transfer of the digital planning data allows the fabrication of surgical guides in an external center without the need of physical transport, which reduces the logistic effort and expense of the central fabrication of surgical guides.
Behavior Management in a Factory Setting

Field: Psychology (Social Sciences)

A multiple-baseline design in which two intervention components of feedback and feedback-plus-praise was applied across 7 departments of a medium-sized furniture manufacturing plant. Daily average worker efficiency was collected for at least 8 weeks in each target department prior to introduction of the first component. This was introuduced in a temporally-staggered fashion across departments, entailed verbal repoll of daily efficiencies to each operative worker, and the visual individual display of this information on chart that were conspicuously posted in the work area. This condition, designated feedback-only, lasted from 8-35 wk. The second component continued with feedback and, in addition, supervisors were coached to contact and praise employees whose efficiencies exceeded predetermined levels or that improved in that direction. This feedback-plus-praise condition was introduced in a temporally-staggered sequence in four departments and lasted from 27 to over 100 weeks. Manipulation checks for graphing and praise were included and a benefits-analysis was conducted. Results were that of 7 relatively independent tests of feedback-only, fully 5 of these resulted in marked and reliable work increases and, of the other 2, one approached significance. Two of 4 tests of the praise component proved reliable and the other two reflected increases in the same direction. Manipulation checks yielded support that feedback was "registered" by all, that praise was given, but not whether the latter was dispensed differentially across project phases. Benefits analyses showed a program-related increase in productivity equivalent to 800-1050 man hours.
B-type natriuretic peptide: use and misuse in the older patient

Field: Medicine (Health Sciences)

Summary B-type natriuretic peptide (BNP) and the inactive N-terminal fragment of the precursor (NT-proBNP) are hormones predominantly produced by the cardiac myocyte. It has been shown that very high levels of circulating natriuretic peptides correlate with a diagnosis of heart failure. In view of this, the current NICE, SIGN and European Society of Cardiology guidelines on heart failure recommend the measurement of natriuretic peptides as part of the diagnostic pathway for patients with suspected heart failure in primary care. Patients should be stratified according to results, with high-risk patients referred and reviewed by specialist services within 2 weeks. There has also been interest regarding the potential use of natriuretic peptides in disease surveillance, therapeutic monitoring and in-patient discharge planning. Consequently, it is a test that we will encounter with increasing frequency in clinical practice. Heart failure is common in older people, hence geriatricians need to have an understanding of the implications of natriuretic peptide levels. The test can be affected by both physiological and pharmacological factors and this should be taken into consideration when interpreting results.
A patient with acute pancreatitis and unusual vermiform stools

Field: Medicine (Health Sciences)

A 66-year-old woman was admitted with severe pancreatitis of unknown aetiology. Medical history disclosed insulin-dependent diabetes. She was treated conservatively with fluid and electrolyte correction. The patient was haemodynamically stable throughout the disease course. On day 4 she developed a paralytic ileus. Parenteral nutrition was initiated. Gradually, the ileus resolved. Enteral feeding was resumed on day 13 via a nasojejunal feeding tube. Over the following days, the patient developed watery diarrhoea. PCR and cultures failed to demonstrate a microbial cause. Suddenly, at day 21, the patient excreted per …
Food Emulsifiers, Effect of Nonionic Emulsifiers on Experimental Dietary Injury of the Liver in Rats

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFood Emulsifiers, Effect of Nonionic Emulsifiers on Experimental Dietary Injury of the Liver in RatsPaul György, Martin Forbes, and Harry GoldblattCite this: J. Agric. Food Chem. 1958, 6, 2, 139–142Publication Date (Print):February 1, 1958Publication History Published online1 May 2002Published inissue 1 February 1958https://pubs.acs.org/doi/10.1021/jf60084a012https://doi.org/10.1021/jf60084a012research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Data from Hypoxic Activation of the PERK/eIF2α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>Supplementary Data - PDF file 113K, This file contains supplementary materials and methods, and the legends of the 14 supplementary figures. Suppl. Table 1 shows the patients characteristic from the clinical study described in main Fig 1. Suppl. Table 2 shows the relationship between LAMP3 protein expression and continuous clinical parameters, incl. HP5. Suppl. Table 3 shows the relationship between LAMP3 protein expression and categorical clinical parameters, incl. FIGO stage. Suppl. Fig 1 shows the association between LAMP3 gene copy number and LAMP3 gene expression in human cervix tumors described in main Fig 1, as well as the LAMP3 gene copy numbers in normal human cervix tissues. Suppl. Fig 2 provides in vitro evidence for the inducibility of the ME180 cancer cell line. Suppl. Fig 3 provides in vivo evidence for the metastatic capacity of the isogenic ME180 cell line, as well as its inducibility. Suppl. Fig 4 shows in vitro validation of the ME180-GADD34-C cells. Suppl. Fig 5 contains the raw data that belongs to main Fig 3C, which shows that Inhibition of UPR signaling suppresses hypoxia-induced lymph node metastasis. Suppl. Fig 6 shows the in vitro validation of ME180 LAMP3-knockdown cells. Suppl. Fig 7 shows representative images of LAMP3 expression in LAMP3 knockdown and empty vector control tumors described in main Fig 4B. Suppl. Fig 8 contains the raw data that belongs to main Fig 4C, which shows that knockdown of LAMP3 inhibits hypoxia-induced lymph node metastasis. Suppl. Fig 9 shows the human VEGF mRNA expression in ME180-GADD34-C orthotopic xenografts described in main Fig 3B. Suppl. Fig 10 shows the quantification of the microvessel density and hVEGF expression in shLAMP3 orthotopic xenografts described in main Fig 4B. Suppl. Fig 11 shows the hypoxic fraction shLAMP3 orthotopic xenografts described in main Fig 4B. Suppl. Fig 12 contains data from the soft agar colony formation assay that shows that knockdown of LAMP3 in HeLa cells inhibits colony formation. Suppl. Fig 13 is supplementary to main Fig 6B and shows that knockdown of LAMP3 in HeLa cells, just like in ME180 cells, inhibits transwell migration. Suppl. Fig 14 is supplementary to main Fig 6D and shows that knockdown of LAMP3 in Caski cells, just like in ME180 cells, inhibits wound closure in the scratch wound healing assay. This figure also shows that overexpression of LAMP3 accelerates wound closure</p>
Neural invasion: a scenic trail for the nervous tumor and hidden therapeutic opportunity.

Field: Medicine (Health Sciences)

Neural invasion (NI) is the invasion of cancer cells into nerves, influencing the pathological characteristics of malignant tumors. NI promotes metastasis and is associated with reduced survival of affected patients. Although known for decades, its prognostic and therapeutic implications have not been not much appreciated due to the scattered information available on its clinical complications. The use of multiple nomenclatures to describe NI also generated confusions among researchers to understand this pathological process. Here, we discuss the multiple classifications of NI and review its clinical complications. Recent findings of the regulatory roles of nerves on tumor growth have fuelled research in this field, and there has been several attempts to molecularly define the NI interface and the cancer cells involved. Therefore, in this review, we discuss the large datasets available to characterize the cancer cells in NI and also discuss the roles of Schwann cells and macrophages participating in NI.
Adaptive Pixel Encoding: An Effective Algorithm for Frame Buffer Compression

Field: Computer Science (Physical Sciences)

Display controller processes a great amount of data within a bounded time and thus requires high memory bandwidth. The memory bandwidth will dominate system performance, especially in embedded systems. In this paper, we propose a hybrid algorithm called APE (Adaptive Pixel Encoding) for loss less frame buffer compression considering high compression performance and real time operation. The algorithm combines dictionary coding and run length coding to achieve a low compression ratio. We integrate APE frame buffer compression architecture into a display controller. Experimental results show that the proposed algorithm gains 19.7% of compression ratio and 66.2% of memory bandwidth reduction ratio during sweep operation. It is much more effective than all previous works.