jimnoneill/paper-to-field-training huggingface dataset:
Data from In Search of a Real “Targeted” Therapy for Thyroid Cancer

Field: Medicine (Health Sciences)

<div>Abstract<p>Over the past 5 years, patients with progressive radioactive iodine–refractory thyroid cancer have responded to “targeted” multikinase inhibitors, which inhibit angiogenesis and not the tumor cell. Here, selumetinib targets the mitogen-activated protein kinase pathway in papillary thyroid carcinoma and shows limited single-agent activity in the patients with tumors that harbor the <i><sup>V600E</sup>BRAF</i> mutation. <i>Clin Cancer Res; 18(7); 1827–9. ©2012 AACR</i>.</p></div>
Growth, Blood Chemistry and Carcass Yield of Broilers Fed Cassava Leaf Meal (Manihot esculenta Crantz)

Field: Agricultural and Biological Sciences (Life Sciences)

A 25-day feeding trial involving 120, 5-week old Anak broilers was carried out in a completely randomized design to evaluate, growth, blood chemistry and carcass yield of broilers fed cassava leaf meal at dietary levels of 0, 5, 10 and 15% respectively. Feed intake, body weight gain, feed conversion ratio and the control (0%) leaf meal were superior (p 0.05) between the treatment group. The cut parts of the carcass showed superior values (p<0.05) in the control treatment and they differed significantly (p<0.05) from broilers on 5, 10 and 15% leaf meal in carcass yield. It is suggested that 5% inclusion of cassava leaf meal could be used in broiler finisher without any deleterious effect on growth, blood chemistry and carcass yield of broilers.
Natural History and Spread of Brazilian Peppertree (Schinus terebinthifolia; Anacardiaceae) in Florida and Its Role in Range Expansion by Tetyra antillarum Kirkaldy (Hemiptera: Scutelleridae)

Field: Agricultural and Biological Sciences (Life Sciences)

Brazilian peppertree (Schinus terebinthifolia Raddi), a native South American tree, has invaded disturbed sites and natural areas in peninsular Florida. We report Brazilian peppertree as a new host for a little-known heteropteran, the Neotropical scutellerid, Tetyra antillarum (Kirkaldy), whose U.S. distribution is restricted to Florida. In 2016 to 2019 and 2021, we collected a total of 10 nymphs (all instars except IV) and 56 adults by beating fruit-laden branches in mid-February, early March, and early April. Multiple introductions of Brazilian peppertree in south Florida and eventual intraspecific hybridization of two haplotypes (Miami area and Gulf Coast) created genotypes more suited to Florida's climate, which fueled aggressive northward expansion in the peninsula. We review the history of Brazilian peppertree's planting in Florida and its northward expansion in the interior of the peninsula. As a corollary, we propose that Brazilian peppertree's northern spread in the peninsula triggered subsequent range expansion by T. antillarum. Our supposition is based on fruit of the novel host being available in fall and winter when fruits of most other woody plants are lacking, coupled with absence of the bug's other known host, gumbo limbo (Bursera simaruba [L.] Sarg.); this tropical tree is not hardy in the Lake Wales Ridge where T. antillarum was most numerous. First collected at Key West in 1887, the scutellerid now is known from the peninsula's northeasternmost county, Nassau, which borders on Georgia. We present new records of T. antillarum from Florida and countries in Central America and the West Indies, and new state records for Mexico. Certain U.S records of T. antillarum posted on the internet are referred to T. bipunctata (Herrich-Schaeffer).
Experimental observations on the etiology of lymphadenoma

Field: Medicine (Health Sciences)

The results recorded in the first part of this paper \nindicate, in The first place, that the encephalitogenic action \nof extracts of leucocyted and other tissues on the brain of the \nrabbit is not due to proteolytic action per se, as the injection \nof extracts of pancreas, as well as of commercial trypsin and pepsi \nentirely failed to reproduce the characteristic syndrome in \nthe rabbit. The result with pancreatic extracts also proves that \na lipolytic ferment plays no part in the production of the \nsyndrome.
Induced CD4+Foxp3+Regulatory T Cells in Immune Tolerance

Field: Immunology and Microbiology (Life Sciences)

Regulatory T lymphocytes are essential to maintain homeostasis of the immune system, limiting the magnitude of effector responses and allowing the establishment of immunological tolerance. Two main types of regulatory T cells have been identified—natural and induced (or adaptive)—and both play significant roles in tuning down effector immune responses. Adaptive CD4 + Foxp3 + regulatory T (iTreg) cells develop outside the thymus under a variety of conditions. These include not only antigen presentation under subimmunogenic or noninflammatory conditions, but also chronic inflammation and infections. We speculate that the different origin of iTreg cells (noninflammatory versus inflammatory) results in distinct properties, including their stability. iTreg cells are also generated during homeostasis of the gut and in cancer, although some cancers also favor expansion of natural regulatory T (nTreg) cells. Here we review how iTreg cells develop and how they participate in immunological tolerance, contrasting, when possible, iTreg cells with nTreg cells.
Time trends of baseline demographics and clinical characteristics of HIV infected children enrolled in care and treatment service in Dar es

Field: Medicine (Health Sciences)

Background: Few studies have described time-based trends of clinical and demographic characteristics of children enrolling in HIV and AIDS care and treatment services. We present findings of a study that explored time-based trends of baseline characteristics among children enrolling into 26 public HIV care facilities in Dar es Salaam, Tanzania. Methods: Children enrolled between October 2004 and September 2011 was included in these analyses. The year of enrollment was used as the primary predictor of interest, and log linear and linear regressions model were used to analyze dichotomous and continuous variables respectively. P-values under 0.05 were considered significant. Results: Among the 6,579 children enrolled, the proportion with advanced disease at enrollment increased from 35% to 58%, mean age increasing from 5.0 to 6.2 years (p < 0.0001), proportion of children less than 2 years decreased from 35% to 29%. While the median hemoglobin concentration rose from 9.1 g/dl to 10.3 g/dl (P <0.0001), proportion with a history of past TB dropped from 25% to 12.8% (P< 0.0001). Over time, health centers and dispensaries enrolled more children as compared to hospitals (P < 0.0001). Temeke district, which has the lowest socioeconomic status among the three districts in Dar es Salaam, had a significant increase in enrollment from 22% to 25% (P = 0.02). Conclusion: We found that as time progressed, children were enrolled in care and treatment services at an older age sicker status as evidenced by increase in mean age and more advanced disease stage at first contact with providers. We recommend more efforts be focused on scaling up early HIV infant diagnosis and enrollment to HIV care and treatment.
Fatty acid compositions of triacylglycerols in flax (Linum usitatissimum L.) seeds with varied seeding dates and nitrogen fertilization in a temperate region of Japan

Field: Agricultural and Biological Sciences (Life Sciences)

(2021). Fatty acid compositions of triacylglycerols in flax (Linum usitatissimum L.) seeds with varied seeding dates and nitrogen fertilization in a temperate region of Japan. Soil Science and Plant Nutrition: Vol. 67, No. 3, pp. 269-276.
Progress, traditions and future directions in research on disasters involving slow-onset hazards

Field: Social Sciences (Social Sciences)

Purpose The importance of onset speed has been stressed by disaster researchers and inter-governmental bodies for some time, but its meaning and knowledge frontier has not been explored in depth. The purpose of this paper is to contextualise disasters involving slow-onset hazards within the broader literature on disasters, assess the current state of knowledge and identify themes in the literature. Design/methodology/approach This paper employs a semi-structured review design with the purpose of identifying both scholarship engaging directly with the term and less obvious but related literatures. Findings The majority of publications that mention slow-onset hazards and their adverse impacts do so only by means of delimitation. The paper finds that there is a great need for empirical and theoretical work on onset and manifestation speed and to test the degree to which existing theories and frameworks of disaster management are also relevant for the study of slow-onset hazard impacts. Research limitations/implications The review identifies several gaps in existing research disasters involving slow-onset hazards and proposes research on community, political, policy and practical challenges, including answering the question of how to secure proactive response to emerging slow-onset hazard impacts. Practical implications In theory, hazards with a gradual and creeping onset are easier to manage and proactively respond to than that of sudden and unexpected ones. Not only do slow-onset hazards provide more lead time, but also a larger potential for proactive response, which in turn provides ample time to take early action to cushion their impacts. Yet, warnings often go unheard and response is put on hold until impacts become unnecessarily costly to reverse. More research on onset speed and gradual manifestation patterns should therefore be carried out. Originality/value Gradually occurring hazards have remained largely absent from the core literature on disasters, including most definitions of the term. This paper represents an initial effort to assess the state-of-the-art on the concept and the phenomenon of disasters involving slow-onset hazards.
Use of Special Ritz Vectors in Dynamic Substructure Analysis

Field: Engineering (Physical Sciences)

A numerical method is presented for the dynamic response analysis of large structural systems that are modeled as substructures. The method is similar to the component mode synthesis technique; however, the generation of the substructure modes is very efficient since the eigenvectors of the substructures are not evaluated. In addition, the characteristics of the loading are used in the algorithm, which can result in improved accuracy with the use of fewer vectors. The purpose of the method is to efficiently evaluate the dynamic displacements and forces within complex structures subjected to a particular type of loading. The technique does produce approximate modeshapes and frequencies; however, this is not the basic purpose of the method. The efficiency and accuracy of the method has previously been demonstrated for the direct dynamic analysis of complete structures. In this paper the method is extended to systems of substructures in which local substructure Ritz vectors are used to reduce the number of dynamic degrees of freedom. The basic algorithm is summarized for substructure application and simple examples are studied by the use of different models.
Timber tales: tracing the origin and species identity of African timbers using plastid genomes

Field: Agricultural and Biological Sciences (Life Sciences)

samples of two timber species (addressing barrier a).Using these samples, we developed whole plastomes that can be used in its entirety or in specific parts for SNP detection and determining the plastid haplotypes (addressing barrier b).Next, we evaluated the spatial distribution of haplotypes and the spatial genetic structure, applied DNA barcoding to blind samples to verify timber claims for the two species, and compared assignment tests with the plastome-wide SNP sets (addressing barrier c).Finally, we explored the integration of genetic tracing with multi-element and isotopic analysis (addressing barrier d).In this way, the thesis addresses critical challenges in the field of tropical timber tracing and contributes to the fight against illegal logging.
PhasiRNAnalyzer: an integrated analyser for plant phased siRNAs

Field: Computer Science (Physical Sciences)

Phased siRNAs (phasiRNAs) are a class of small interfering RNAs (siRNAs) which play essential roles in plant development and defence. However, only a few phasiRNAs have been extensively studied due to the difficulties in identifying and characterizing plant phasiRNAs by plant biologists. Herein, we describe a comprehensive and multi-functional web server termed PhasiRNAnalyzer, which is able to identify all crucial components in plant phasiRNA’s regulatory pathway (phase-initiator→PHAS gene→phasiRNA cluster→target gene). Currently, PhasiRNAnalyzer exhibits the following advantages: I) It is the most comprehensive platform which hosts 170 plant species with 256 genome data, 438 cDNA data and 271 degradome data. II) It can identify all crucial components in phasiRNA’s regulatory pathway, and verify the interactions between phasiRNAs and their target genes based on degradome data. III) It can perform differential expression analysis of phasiRNAs on each PHAS gene locus between different samples conveniently. IV) It provides the user-friendly interfaces and introduces several improvements, primarily by making more accurate and efficient analysis when dealing with deep sequencing data. In summary, PhasiRNAnalyzer is a comprehensive and systemic phasiRNA analysis server with high sensitivity and efficiency. It can be freely accessed at https://cbi.njau.edu.cn/PPSA/.
The Effects of Emotion and Communication on Job Involvement

Field: Business, Management and Accounting (Social Sciences)

Although certain topics such as scientific management, human-centered research, communication, and job involvement have been actively studied for the purpose of enhancing organizational performance, there have been relatively few academic studies of emotion, despite its importance to this subject. Accordingly, the purpose of the present study was to verify the effects of emotions on job involvement. Results of the study showed that communication and consideration influence job involvement, while emotions play a partially mediating role on communication and job involvement. Researchers argue that communication should be improved in order to achieve better organizational performance, and that performance is related to verbal communication. All people have emotions, and they may express them through words. In addition, emotions and words can significantly influence individuals, and, as a result, they may influence individual and organizational success. Thus, the communication of positive emotions is an important element of successful organizational development, and organizations should create environments that foster such communications.Keywords: Communication, Consideration, Emotion, Job Involvement, Organization Development
In vitro μελέτη της απελευθέρωσης νεώτερων αντιμικροβιακών ουσιών από κυλίνδρους οστικού τσιμέντου φωσφορικού ασβεστίου και από κυλίνδρους οστικού τσιμέντου ακρυλικού ασβεστίου

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

SUMMARY Therapeutic approach of chronic osteomyelitis remains a problem in every day clinical practice mainly due to adverse side effects (in IV or pos therapy). Local antibiotic delivery systems have evolved in an attempt to reduce the extended use of IV or pos therapy. AIM : The evaluation of in vitro release of teicoplanin and moxifloxacin (in 3% concentration) impregnated in acrylic and phosphate bone cement respectively. METHODS: 10 specimens (5 for each antibiotic bone cement) are prepared in sterile vials. Mueller Hinton broth which is added in every vial covering the free surface of the cement , is replaced every 24 hours. The daily obtained samples have been kept in -80C until antibiotics concentrations are determined. ( bioassay and HPLC). RESULTS : Moxifloxacin was eluted at very high concentrations within the first two weeks. Concentrations remained above the MICs of the most common pathogens related to bone infection . It is concluded that both cements may allow the adequate in vitro elution of moxifloxacin . The latter results support their application in experimental models of osteomyelitis. _ Teicoplanin concentrations was 10 times higher within the first week from acrylic bone cement compared to concentrations eluted from NORIAN-teicoplanin .The elution of teicoplanin from acrylic bone cement lasted for 24 days. Concentrations remained above the MICs of the most common pathogens related to bone infection, although lasted less than the moxifloxacin bone cement system . 138 CONCLUSIONS The release of moxifloxacin from both acrylic and phosphate bone cement is promising and should be tested in in vivo models.
Effects of excitatory transcranial magnetic stimulation on deceptive behaviour

Field: Neuroscience (Life Sciences)

The present study investigated the effects of excitation of the dorsolateral prefrontal cortex (DLPFC) with repetitive transcranial magnetic stimulation (rTMS) on deceptive behaviour. The event-related potential (ERP) component P300 is well known as a neural marker of deception. P300 amplitude was examined in response to critical, familiar, and neutral stimuli in a task similar to the concealed information test. The electroencephalography (EEG) of 13 volunteers was recorded combined with rTMS. We did not find a difference in response to rTMS between right and left DLPFC as initially expected. However, TMS elicited a higher mean P300 amplitude to the critical stimulus compared to sham condition. Therefore, noninvasive prefrontal cortex excitation by rTMS can be used to increase the sensitivity of P300 to critical items in an analogue of the concealed information test.
Requirements for a Regional Information Infrastructure for Sustainable Communities-The Case for Community Informatics

Field: Computer Science (Physical Sciences)

Although many community informatics (CI) efforts to date have been successful (see e.g., Beamish, 1995), few appear to have been part of a strategic response to the “big” problems of the environment and society; typically they address specific needs of particular communities, and have limited influence outside their scope. Nevertheless, they have created a wealth of experience which may be used in new endeavors, since they have exercised numerous technologies and economic models. However, if the concept of “community” is going to play a more important role in establishing sustainable economic, ecological and cultural systems for the future, community informatics will need to develop not just better solutions, but a strategy to support the community ideal. This chapter argues that the object of such a strategy should be a regional information infrastructure (RII), whose purpose is to provide a knowledge-processing context for physical communities. The definition of requirements for an RII is effectively an expression of a community ideal, or vision, in terms of a technological strategy. Technical architectures stemming from the requirements represent a repository of solution patterns which can be reused and evolved. Of course, any such strategy is predicated not only on a certain kind of community vision, but the idea that “community” is indeed an effective response to global and local problems; thus the themes of community and knowledge are firstly explored as a background to the discussion of the RII.
En bloc kidney transplantation of an infant to an adolescent girl - one-year follow-up

Field: Medicine (Health Sciences)

Introduction. En bloc kidney transplantation (EBKT) overcomes the problems of insufficient nephron mass of the solitary kidney of the youngest donors and the creation of a vascular anastomosis with small blood vessels. Although there are positive experiences with EBKT in adult patients, there is little data in pediatric recipients. Case outline. The kidney donor was a six-month-old male infant (7 kg), and the recipient was a 16-year-old adolescent girl (58.7 kg). The estimated glomerular filtration rate increased during the one-year follow-up after EBKT and reached 88.8 ml/min/1.73 m2, which was accompanied by an increase in the dimensions of the medial and lateral kidneys. Normalization of proteinuria and tubular functions occurred six and 12 months after transplantation, respectively. Conclusion. EBKT in an adolescent girl was performed without vascular complications, with satisfactory kidney function and physiological values of proteinuria after a one-year follow-up. EBKT of infants could increase the number of cadaveric donors but also enable better function and survival of the graft, given that the growth and functional maturation of the infant?s kidneys continue postnatally in the body of the graft recipient.
Predictors and clinical impact of pre‐existing and acquired thrombocytopenia following transcatheter aortic valve replacement

Field: Medicine (Health Sciences)

Background Data are limited regarding transcatheter aortic valve replacement (TAVR)‐related thrombocytopenia (TP). We sought to thoroughly characterize the presence, clinical impact, and severity of TP associated with TAVR. Methods and Results Data were collected from 90 patients who underwent TAVR using the Edwards SAPIEN valve (59 TF, 29 TA, 2 Tao). Platelet counts were evaluated peri‐procedurally and for 8 days following TAVR. Platelet levels were compared and patients were divided into a no TP (No‐TP) group 1, acquired (new) TP (NTP) group 2, pre‐existing (pre‐TAVR) TP (PTP) group 3, and further stratified based on the severity of TP: mild (M) TP (100–149 × 10 3 cell/µL) and moderate–severe (MS) TP (<100 × 10 3 cell/µL). Pre‐TAVR point prevalence and post‐TAVR incidence of TP were 40% and 79%, respectively ( P < 0.001); nadir platelet count in all groups occurred day 4 post‐TAVR. Baseline predictors for developing MS TP in groups 2–3 included baseline TP, leaner body mass, smaller pre‐procedural aortic valve area, higher peak aortic jet velocity, and worsening baseline renal function. Development of “major” TP (nadir platelet count <100 × 103 cell/µL, ≥50% decrease) predicted a higher risk of major vascular complications (OR 2.78 [95% CI, 1.58–3.82]) and major bleeding (OR 3.18 [95% CI, 1.33–5.42]) in group 3. Conclusion TAVR‐related TP is predictable and classification by PTP and TP severity prior to TAVR allows for better risk stratification in predicting in‐hospital clinical outcomes. Major TP in the presence of worsening TP is predictable and is associated with worse clinical outcomes. © 2014 Wiley Periodicals, Inc.
Some Influencing Factors of Broiler Demand on Household Consumers in Pamulang Dis-trict,Tangerang Regency

Field: Economics, Econometrics and Finance (Social Sciences)

The research was carried out to study some influencing factors of broiler demand on household consum-ers
in Pamulang District, Tangerang Regency. The research was done on July to August 2007, by survey
method. Sampling method was done by multistage cluster sampling. The primary data were collected by
observation and interview with 64 respondents and the secondary data were obtained from the interrelated
institution. The data were analyzed by Cobb – Douglas regression model with SPSS Program 12 version.
The results showed that the average of broiler demand was 1.98 Kg/cap/month. The broiler demand was
highly significant (P<0.01), that was influenced by broiler price (x 1 ), layer egg price (x 2 ), family income (x 3 ),
family member (x 4 ) and preference (x 5 ) with R 2 =0.888. The partial test showed that the broiler price, family
member quantity and preference were highly significant (P<0.01) that was influenced by the broiler demand.
The price demand elasticity was elastic with the value of -2.436. The value of income elasticity was 0.108
that indicated inelastic, it means that the broiler was normal product. The price value of cross elasticity was
-0.078, it means that layer egg was not substitution product of broiler .
Keywords : Broiler, Demand, Elasticity