jimnoneill/paper-to-field-training huggingface dataset:
ELIOT: A platform to navigate the E3 pocketome and aid the design of new PROTACs

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Proteolysis‐targeting chimeras (PROTACs) are novel therapeutics for the treatment of human disease. They exploit the enormous potential of the E3 ligases, a class of proteins that mark a target protein for degradation via the ubiquitin–proteasome system. Despite the existence of several E3 ligase‐related databases, the choice of the functioning ligase is limited to only 1.6% of those available, probably due to the fragmentary understanding of their structures and their known ligands; in fact, none of the existing databases report detailed studies covering their 3D structure or their pockets. Here, we report ELIOT (E3 LIgase pocketOme navigaTor), an accurate and complete platform containing the E3 ligase pocketome to enable navigation and selection of new E3 ligases and new ligands for the design of new PROTACs. All E3 ligase pockets were characterized with innovative 3D descriptors including their PROTAC‐ability score, and similarity analyses between E3 pockets are presented. Tissue specificity and their degree of involvement in patients with specific cancer types are also annotated for each E3 ligase, enabling appropriate selection for the design of a PROTAC with improved specificity. All data are available at https://eliot.moldiscovery.com .
Letters to Louis: Marital Dissolution Through the Social Construction of Lived Experience

Field: Social Sciences (Social Sciences)

This article examines the author's narrative within letters written to her husband over a span of several years. I examine how a marriage dissolves from the inside out, from the perspective of the lived experience of one member of the marriage. The primary research focus is how individuals living within troubled marriages construct their own marriage. Although we know much about what predicts divorce, little research considers the social construction of marriage from the perspective of the person living within that marriage. Drawing on symbolic interactionism, this autoethnographic analysis of my letters to Louis reveals an insider's view of how a marriage dissolves. Gottman's Oral History Interview coding is used as a tool of analysis throughout.
Applying Taiwan Data Cube Experiences in Thailand and Paraguay

Field: Earth and Planetary Sciences (Physical Sciences)

This paper demonstrates the development of Taiwan Data Cube, TWDC, and also showcases successful applications in crop monitoring and wildfire in Thailand and Paraguay respectively. TWDC is an enhancement version of Open Data Cube, ODC, which is being promoted by the Committee on Earth Observation Satellites, CEOS. TWDC Enhancement includes Imagery Data as well as High-Performance Computing Implementation, Private-Public Cubes Service Framework, and Integrated Cloud Analysis. TWDC contains imagery of Sentinel-l & 2, Landsat, and Formosat-2 & -5.
A Meta Analysis on Relationship between Alcohol Dehydrogenase2 Polymorphisms and Risk of Esophageal Cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Objective To study the relationship between ADH2 genetic polymorphisms and susceptibility to esophageal cancer by Meta-analysis.Methods Database from PubMed,CNKI,Wanfang and Vip searches were collected and relevant papers and the literatures were analyzed by Meta analysis.Odds ratio of ADH2 genotype distributions in patients with esophageal cancer and healthy controls was calculated.Heterogeneity test and pooled OR calculation were analyzed by RevMan 5 soft ware.Results Of the case-control studies selected for this Meta analysis,a total of 1 419 esophageal cancer cases and 2 776 controls were included.The pooled Odds Ratio of ADH2 genotype *1/*1 vs.*1/*2+*2/*2 was 2.83(95% CI=1.89～4.26);*2/*1 vs.*2/*2 was 1.57(95% CI=1.31～1.88);*1/*1 vs.*2/*2 was 3.31(95% CI=1.97～5.59).Conclusion It was demonstrated that there was the relationship between ADH2 genetic polymorphisms and susceptibility to esophageal cancer.In other words,the drinkers carring the ADH2 genotype *1 associated with the increased risk of esophageal cancer.
Specifying and verifying requirements of real-time systems

Field: Computer Science (Physical Sciences)

Article Specifying and verifying requirements of real-time systems Share on Authors: Kirsten M. Hansen Department of Computer Science, Technical University of Denmark, Bldg. 344, DK 2800 Lyngby, Denmark Department of Computer Science, Technical University of Denmark, Bldg. 344, DK 2800 Lyngby, DenmarkView Profile , Anders P. Ravn Department of Computer Science, Technical University of Denmark, Bldg. 344, DK 2800 Lyngby, Denmark Department of Computer Science, Technical University of Denmark, Bldg. 344, DK 2800 Lyngby, DenmarkView Profile , Hans Rischel Department of Computer Science, Technical University of Denmark, Bldg. 344, DK 2800 Lyngby, Denmark Department of Computer Science, Technical University of Denmark, Bldg. 344, DK 2800 Lyngby, DenmarkView Profile Authors Info & Claims SIGSOFT '91: Proceedings of the conference on Software for citical systemsSeptember 1991 Pages 44–54https://doi.org/10.1145/125083.123051Online:01 September 1991Publication History 23citation388DownloadsMetricsTotal Citations23Total Downloads388Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Interest rate, price level, and the inflation rate: Evidence from the UK during the gold standard regimes

Field: Economics, Econometrics and Finance (Social Sciences)

Abstract This paper empirically investigates the Gibson Paradox and the Fisher Effect for the UK during different metallic and non‐metallic regimes. The paper applies long‐span monthly data on the long‐term interest rate and the price index from 1790 to 1931. The ARDL cointegration is employed to study the long‐term relationship. Significant evidence is provided for the paradox during the uninterrupted gold standard era of the UK (1821–1914). We also find evidence of the paradox during the short‐term gold exchange standard era (1925–1931). Further results also confirm the Fisher Effect during the 1821–1914 period, providing some backing to its ability to explain the paradox. This is further asserted by the short‐run mutual influence between the rate of interest and the inflation rate.
Recurrent simultaneous two-vessel very late stent thrombosis

Field: Medicine (Health Sciences)

Kontext: Trombóza stentu má katastrofální důsledky. Nová generace lékových stentů (drug eluting stent, DES) přinesla významné zlepšení účinnosti a hlavně bezpečnosti. Velmi pozdní trombóza stentu je sice vzácnou komplikací, ale ještě vzácnější je velmi pozdní trombóza stentu současně ve dvou tepnách při použití DES druhé generace. Kazuistika: V roce 2018 byl do naší nemocnice přijat 43letý muž pro infarkt myokardu bez elevací úseků ST (non-ST elevation myocardial infarction, NSTEMI) pro významné změny na proximálních segmentech ramus interventricularis anterior (RIA) a ramus circumflexus (RCx) řešené implantací dvou DES. Po dvou letech bez problémů byl muž znovu přijat do nemocnice pro infarkt myokardu přední stěny s elevacemi úseku ST (ST-elevation myocardial infarction, STEMI). Koronarografie prokázala významné stenózy dvou dříve ošetřených tepen. Byla provedena primární perkutánní koronární intervence (percutaneous coronary intervention, PCI) s implantací stentů uvolňujících sirolimus do RIA a RCx. Pacient následně užíval kyselinu acetylsalicylovou v dávce 100 mg a clopidogrel v dávce 75 mg denně po dobu jednoho roku. V dubnu roku 2021 se pacient dostavil na oddělení urgentního příjmu pro nepolevující svíravou bolest na hrudi. Elektrokardiogram prokázal infarkt přední stěny myokardu s elevacemi úseku ST. Během dvou hodin od nástupu symptomů byl muž převezen na katetrizační sál. K našemu překvapení byla zodpovědná léze přítomna na stejných dvou tepnách. Do RIA jsme implantovali stent 4 × 25 mm uvolňující sirolimus a léze na RCx byla ošetřena non-compliantním balonkem 3 × 20 mm nafouknutým na 14 atm. V obou případech pacient užíval jako antiagregační léčbu kyselinu acetylsalicylovou po 12 měsících duální antiagregační léčby. Až na citové vypětí předcházející oběma příhodám nebyl zjištěn žádný spouštěcí faktor. Závěr: Velmi pozdní trombóza stentu v důsledku složitých mechanismů představuje příhodu s katastrofálními důsledky. Tato kazuistika popisuje vzácnou formu rekurentní, velmi pozdní trombózy stentu a je ve shodě s nedávno publikovanými doporučenými postupy (guidelines), v nichž se navrhuje vytvořit kategorii pacientů s vysokým rizikem ischemie, kteří vyžadují dlouhodobou duální antiagregační terapii. © 2022, ČKS.
Association of rs16917496 polymorphism at the miR-502 binding site in the SET8 3'UTR with the risk of Prostate Cancer and benign prostatic hyperplasia

Field: Medicine (Health Sciences)

Background: MicroRNAs (miRNAs) can bind to the 3'-untranslated regions (UTRs) of messenger RNAs, where they interfere with translation and thereby regulate cell differentiation, apoptosis, and tumorigenesis. Genetic polymorphisms in the 3'-UTRs targeted by miRNAs alter the strength of miRNA binding in a manner that affects the behavior of individual miRNAs. The histone methyltransferase SET8 has been reported to be a regulator of Tumor Protein 53 (TP53) methylation, a tumor suppressor gene, and regulate genomic stability. Furthermore, an association between the TP53 and Prostate Cancer has been reported in several studies. The present study aimed to evaluate whether (rs16917496) polymorphism at the miR-502 binding site in the 3' untranslated region of the histone methyltransferase SET8 is associated with the expression of this gene in Benign Prostatic Hyperplasia (BPH) and prostate cancer (PCa) patients.

Materials and Methods: We examined whether an rs16917496 polymorphism is associated with the risk of PCa and BPH in the Iranian population. This case-control study included 40 patients with pathologically confirmed PCa, 59 patients with BPH, and 45 controls. The rs16917496 polymorphism was determined using a restriction fragment length polymorphism (RFLP). Results: We found significant association of rs16917496 in benign prostatic hyperplasia (BPH). The most frequent genotype in the control, prostate cancer, and BPH groups were TT, TC, and CC, respectively. Conclusion: This study demonstrates that the heterozygote genotype of the SET8 polymorphism in the mir-502 gene could be considered a risk factor for the emergence of prostate cancer.
Generalized Friis Transmission Formula Using Active Antenna Available Power and Unnamed Power Gain

Field: Engineering (Physical Sciences)

We use the concept of active antenna available power to derive a generalization of the Friis transmission formula for multiport antenna systems. With beamformer weights chosen such that the array patterns are the same when transmitting and receiving, the active antenna available power at the receiving antenna divided by the input power at the transmitter is symmetric under link direction reversal in the near field as well as the far field. These results generalize the Friis transmission formula to beamformed multiport antenna systems in an arbitrary reciprocal propagation environment.
Laparotomy findings in lymphangiogram-staged I and II non-Hodgkin's lymphomas

Field: Medicine (Health Sciences)

Ninety patients with Stage I or II, including extranodal (E), presentations of non-Hodkin's lymphoma were investigated by laparotomy, either for the definitive staging of patients with peripheral presentations or for diagnosis of abdominal disease. Sixty-eight patients had staging laparotomies after extensive work-up, which included lymphangiography and bone marrow biopsy. The remaining 22 patients had laparotomies for diagnosis of abdominal symptoms or for management of unrelated surgical problems, with lyphoma being found incidentally. The incidence of positive abdominal findings in the 68 patients who had staging laparotomies depended on histologic subtype. In nodular lymphoma patients, abdominal disease was found in 17 of 28 (61%) and in diffuse lymphoma patients, in 9 of 40 (22.5%). For patients with nodular lymphomas upstaged by laparotomy, the positive findings tended to cluster around an axis consisting of the celiac, porta-hepatic, para-aortic, and root of the mesentery lymph nodes. In addition, 64% of these patients had splenic involvement. For the diffuse lymphomas upstaged by laparotomy, the distribution of positive findings was similar to that of the nodular lymphoma group; however, only 1 patient had splenic involvement. By contrast, in approximately half of the diffuse lymphoma patients who had laparotomies for diagnosis, the gastrointestinal tract was found to be involved in addition to the previously cited lymph nodes.
[Individual variations in the frequency of chromosome aberrations following exposure to chemical mutagens. III. Interindividual differences at different stages of the cell cycle].

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The object of this investigation was the sensitivity to chemical mutagens of chromosomes of human lymphocytes obtained from different individuals. The distribution of individuals with respect to their sensitivity to fotrin and cytosine-arabinoside was studied. Tests for two characteristics were used, viz. "the percent of aberrant metaphases" and "the number of chrimosome breaks per 100 cells". It is shown by the statistical analysis, that the distribution does not depend on the stage of the cell cycle. The distribution of the individuals tested with respect to their sensitivity to mutagens was shown to be normal. Certain recommendations concerning the planning of experiments and the exposure of the experimental data are given by the authors.
Phenolic compounds: antioxidant and larvicidal potential of Smilax brasiliensis Sprengel leaves

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Smilax brasiliensis is a medicinal species of the Brazilian Cerrado. The extract and fractions of this plant were analysed by LC-DAD-MS. Identified constituents included glycosylated and non-glycosylated flavonoids, especially quercetin, and phenylpropanoids, such as chlorogenic acids. The antioxidant activity was significantly more pronounced for the methanol extract and fractions than that of the commercial antioxidant 2,6-di-tert-butyl-4-methylphenol (BHT). Maximum larvicidal activity of 85.83% was recorded in the dichloromethane fraction (LC50 = 469.78 µg mL-1). The methanol extract and fractions presented low toxicity to larvae of the shrimp brine Artemia salina, indicating selectivity for C. quinquefasciatus. These results contribute to the phytochemical study of S. brasiliensis. These compounds were identified for the first time in this species and encourage additional work on the isolation of compounds present in the extract and fractions of S. brasiliensis to evaluate the possibility of using them as natural sources of antioxidants, since cytotoxic effects were not demonstrated.
Acute Effects of Whole-Body Vibration Exercises at 2 Different Frequencies Versus an Aerobic Exercise on Some Cardiovascular, Neuromotor and Musculoskeletal Parameters in Adult Patients With Obesity

Field: Medicine (Health Sciences)

Whole-body vibration exercise (WBVE), a nonimpact, viable and safe type of exercise, has been reported to be useful in the physical rehabilitation of obesity. Aim of the study was to compare the acute effects of WBVE with a session of walking and running (AER) on cardiovascular, neuromotor and musculoskeletal parameters in obese subjects. Sixteen adult obese subjects performed 3 tests (WBVE at 30 and 45 Hz, AER) randomly in different days. An increase in heart rate was recorded after AER and 45 Hz WBVE (p < 0.001), while only AER increased systolic ( p = 0.003) and diastolic blood pressure ( p = 0.004) and ratings of perceived exertion ( p < 0.001). All 3 exercises determined lactate increase [AER p < 0.001, 45 Hz ( p = 0.04), 30 Hz ( p = 0.03) WBVE] and sit-and-reach (AER p = 0.002, 45 and 30 Hz WBVE p < 0.001) and fingertip-to-floor improvements (AER p = 0.003, 30 and 45 Hz WBVE p < 0.001), while only 30 Hz WBVE determined improvement in stair climbing test ( p < 0.05). Considering the lack of effects of 30 Hz WBVE on the cardiovascular system and fatigue and its positive effect on flexibility and muscle power, this procedure can be considered an appropriate exercise protocol for the obese population.
A REVIEW ON NUTRITIONAL AND HEALTH BENEFITS OF SOYBEAN

Field: Agricultural and Biological Sciences (Life Sciences)

Asia is the origin of soybean, a crop that is significant both economically and nutritionally. Soybeans are rich in folic acid and iso-flavonoids; used in healthy diets all over the world. Because of their possible positive effects on human health, dietary soy products are attracting more and more scientific attention. Protease inhibitors, isoflavones, proteins or peptides, and saponins are the significant soy components that demonstrate biological activity. Soybean and its constituents have anti-inflammatory, anti-oxidant, anti-diabetic, and anti-proliferative qualities. The eating of these foods has been linked to a number of potential health benefits, including the prevention of immune system diseases, obesity, diabetes, cardiovascular diseases, and certain types of cancer. Numerous studies have demonstrated that high-protein soy products contribute to cholesterol lowering. The topic of this review article is soybeans, their products, and their possible use in the diagnosis, treatment, and prevention of a range of chronic illnesses. Research on new bioactive components of soybeans that are beneficial to health may eventually lead to their use in pharmaceutical development and functional foods, which may eventually replace synthetic medications with a variety of negative side effects.
Small bowel tumours: yield of enteroscopy.

Field: Medicine (Health Sciences)

A total of 258 patients with obscure gastrointestinal bleeding were referred for small bowel enteroscopy, a procedure which allows endoscopic evaluation of most of the small intestine. A small bowel tumour was found in 5% of patients. In 50% of patients no diagnosis could be made, but when the cause of obscure bleeding was discovered small bowel tumours were the single most common lesion in patients younger than 50 years. Small bowel tumours causing gastrointestinal bleeding may remain undetected despite extensive diagnostic evaluation. We conclude that small bowel tumours are the most common cause of obscure gastrointestinal bleeding in patients less than 50 years of age. Small bowel enteroscopy is diagnostic of small bowel tumours even when all previous diagnostic studies, including enteroclysis and angiography, are negative.
Dealing with sensor displacement in motion-based onbody activity recognition systems

Field: Computer Science (Physical Sciences)

We present a set of heuristics that significantly increase the robustness of motion sensor-based activity recognition with respect to sensor displacement. In this paper placement refers to the position within a single body part (e.g, lower arm). We show how, within certain limits and with modest quality degradation, motion sensorbased activity recognition can be implemented in a displacement tolerant way. We first describe the physical principles that lead to our heuristic. We then evaluate them first on a set of synthetic lower arm motions which are well suited to illustrate the strengths and limits of our approach, then on an extended modes of locomotion problem (sensors on the upper leg) and finally on a set of exercises performed on various gym machines (sensors placed on the lower arm). In this example our heuristic raises the displaced recognition rate from 24% for a displaced accelerometer, which had 96% recognition when not displaced, to 82%.
Strategies to reduce the cost of mutagenicity screening with the Salmonella assay

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract An extensive Salmonella assay database was analyzed in order to develop strategies to reduce costs of screening chemicals for mutagenicity. This database was obtained from testing 941 samples (representing 799 chemicals), 36% of which were judged mutagenic. Strains TA98, TA100, TA1535, and TA1537 without activation, with rat liver S‐9, and with hamster liver S‐9, make up the 12 strain/ activation combinations considered here. The testing strategies examined consist of two or three stages; a positive result at any stage is regarded as definitive and stops the testing. Sequential testing improves efficiency by eliminating the need for further experimentation once a chemical has been found to be mutagenic. Consequently, costs and effort are reduced. For screening chemicals in the Salmonella assay, it is our recommendation that a sequential testing scheme be adopted whose initial stage consists of TA 100.
A case of deficiency of the seventh component of complement in man. Biological properties of a C7-deficient serum and description of a C7-inactivating principle.

Field: Immunology and Microbiology (Life Sciences)

The serum of a 13-year-old healthy boy was found to be deficient in whole complement activity. The seventh component of complement could not be detected by functional assays whereas the titres of the other components were found within the normal range. An attempt to detect C7 by immunodiffusion against an antiserum to human C7 also failed. The functions of C1-C6 were normal with respect to opsonizing activity, immune adherence, and the ability to generate chemotactic activity. However, those functions that require the whole complement sequence such as bactericidal and haemolytic activity were found to be absent. Furthermore, the occurrence of a C7-inactivating principle was demonstrated in the C7-deficient serum. This principle inactivated C7 both in the fluid phase and in its cell-bound state. Some physicochemical parameters of the inactivator are described and its possible nature is discussed.
Extensive presentation of a community effort

Field: Environmental Science (Physical Sciences)

This paper shows the results of a community effort aiming at retrieving CO2 and CH4 columns from satellites, providing monthly maps of these quantities, and evaluating the quality of these products.The combination of the satellite products, through a median-based procedure, provides a "best-estimates".This paper is well presented and provide an up-to-date assessment of the XCO2 and XCH4 retrievals.As such, it is a needed contribution by and for the remote sensing community aiming at greenhouse gases retrievals from space.The paper is very clear, and presented in a balance way.It can be published as such C1