jimnoneill/paper-to-field-training huggingface dataset:
Investigation of Slitrk1 in Rohon Beard Sensory Neurons in 1 and 5 Day Zebrafish

Field: Neuroscience (Life Sciences)

The growth of axons and the ability of an axon to find its synaptic partner is an important part of nervous system development. Transmembrane proteins on the surface of neurons are an integral part of forming these connections. A particular family of transmembrane proteins that is involved in nervous system wiring is the Slitrk family. Slitrks have been linked to disorders such as OCD, Tourette’s and other neurological disorders, yet little is known about their cellular function. Zebrafish are convenient vertebrate model organisms to study Slitrks because their nervous system is comparable to the human nervous system. Slitrk1 mRNA was found to be abundant in the developing spinal cord of zebrafish, however little is known about its function in spinal cord wiring. The Slitrk1 protein was studied in 24-hour fish and 5-day-old fish using immunostaining techniques to see if Slitrk1 is present in Rohon Beard sensory neurons. Slitrk1 was detected in Rohon beard cells in zebrafish at 2,3 and 5 days post fertilization and a small amount of Slitrk1 protein was detected in Rohon Beard cells in zebrafish 24 hours post fertilization. This early expression suggests that Slitrk1 plays a role in Rohon Beard axon growth or synapse formation. In the future we plan to look at branching patterns in Rohon Beard neurons to see if Slitrk1 is required for proper Rohon Beard sensory neuron wiring.
Identification of a Dysferlin Gene Mutation in a Korean Case with Miyoshi Myopathy

Field: Medicine (Health Sciences)

Recent genetic and immunohistochemical analyses have shown that Miyoshi myopathy (MM) is caused by a mutation in the DYSF gene, which induces dysfunction of dysferlin. The author described one patient showing characteristic MM phenotype with deficiency of dysferlin on immunohistochemistry. Direct DNA sequencing of whole exons of DYSF gene revealed one homozygous missense mutation (G1165C) on exon 12, which let to an amino acid substitution from the glutamic acid to glutamine at the 389 of the peptide sequence in this patient. This is the first reported case of MM confirmed by immunohistochemical and genetic analyses in Korea.
Utility-Driven End-to-End Network Slicing for Diverse IoT Users in MEC: A Multi-Agent Deep Reinforcement Learning Approach

Field: Computer Science (Physical Sciences)

Mobile Edge Computing (MEC) is crucial for reducing latency by bringing computational resources closer to the network edge, thereby enhancing the quality of services (QoS). However, the broad deployment of cloudlets poses challenges in efficient network slicing, particularly when traffic distribution is uneven. Therefore, these challenges include managing diverse resource requirements across widely distributed cloudlets, minimizing resource conflicts and delays, and maintaining service quality amid fluctuating request rates. Addressing this requires intelligent strategies to predict request types (common or urgent), assess resource needs, and allocate resources efficiently. Emerging technologies like edge computing and 5G with network slicing can handle delay-sensitive IoT requests rapidly, but a robust mechanism for real-time resource and utility optimization remains necessary. To address these challenges, we designed an end-to-end network slicing approach that predicts common and urgent user requests through T distribution. We formulated our problem as a multi-agent Markov decision process (MDP) and introduced a multi-agent soft actor–critic (MAgSAC) algorithm. This algorithm prevents the wastage of scarce resources by intelligently activating and deactivating virtual network function (VNF) instances, thereby balancing the allocation process. Our approach aims to optimize overall utility, balancing trade-offs between revenue, energy consumption costs, and latency. We evaluated our method, MAgSAC, through simulations, comparing it with the following six benchmark schemes: MAA3C, SACT, DDPG, S2Vec, Random, and Greedy. The results demonstrate that our approach, MAgSAC, optimizes utility by 30%, minimizes energy consumption costs by 12.4%, and reduces execution time by 21.7% compared to the closest related multi-agent approach named MAA3C.
[Role of autologous antebrachial arteriovenous fistula for vascular access in hemodialysis].

Field: Medicine (Health Sciences)

Numbers of arteriovenous (AV) fistula creation increase worldwide. Hemodialysis is more effective, patients live longer, they need more access operation. The optimal strategy for the order and sequence of the different type and localization of AV fistulas remains obscure. Based on internationally acclaimed guidelines, autogenous access should be performed whenever possible and the first operation of choice is the radio-cephalic fistula at the wrist, the second type is the elbow fistula. The area between the standard exposures means also good access area and its usage is not emphasized properly. At our department the performance of autogenous fistulas have always been favoured. Beside the wrist radio-cephalic and elbow fistulas a significant number of autologous forearm AV fistulas has been operated. Our aim was to study the short and long term results of the autogenous forearm fistulas at atypical anatomic positions. We also examined whether the patency rate is affected by different variables as diabetes mellitus, acute or chronic operative situation, the indication of surgery, the quality of thrill at the end of shunt creation, the diameter and quality of the vein. Between 1997 and 2005 we performed 1018 AV shunts in an academic tertiary care center. 97 autologous antebrachial AV shunts were performed. The average follow up time was 31.3 months. The primary patency rate was 97%, 92% and 63% at the end of the first, second and sixth years, respectively. The patency rate was not significantly affected by any of the examined variables mentioned above. The patency rate of the autologous antebrachial AV shunt is comparable to the wrist and elbow fistulas, so our results support the practice of performing fistula at this atypical localization. More proximal autologous fistulas and prosthetic graft implantation could be postponed, this way valuable time could be saved for the uremic patients.
Two iatrogenic dissections during single percutaneous coronary intervention

Field: Medicine (Health Sciences)

Cardiologia CROATICA 80-year old female patient, presenting with unstable angina, was transferred to our hospital from the regional hospital. Coronary angiography revealed separate ostia of the left anterior descending artery (LAD) and the circumflex artery (Cx). Borderline stenosis of the ostium of the LAD with tight stenosis of its middle segment as well as distal tortuosity was observed. Cx and right coronary artery (RCA) were without significant lesions. We decided to proceed with an ad hoc percutaneous coronary intervention in the middle segment of the LAD. During advancement of the guidewire (Terumo Runtrough NS Intermediate) dissection, in the region of the lesion, developed with a complete lumen closure. Patient became hypotensive with ST-segment elevation. Subsequent attempts to cross the dissection resulted in multiple disengagements of the guiding catheter (XB LAD, 6Fr) together with its prolapse to the proximal Cx. Eventually this resulted in the dissection with a partial lumen obstruction of the proximal part of the Cx. Because of it, the proximal part of Cx was directly stented and the guiding catheter was exchanged (JL 4,0, 6Fr). After that, we were able to cross the dissection of the LAD with a support of an OTW balloon (Terumo Ryujin Plus) and a hydrophilic guidewire with a tapered tip (Asahi Fielder XT). Appropriate positioning of the OTW balloon in the true lumen was confirmed by the injection of the contrast through its lumen. Through the OTW balloon, whose extraction was found rather difficult using the 6 Fr system, standard guidewire (Terumo Runtrough NS Floppy) was introduced. After multiple balloon dilatations stent was successfully deployed in the middle segment of the LAD. Postprocedurally a rise in cardiac enzymes was observed, without electrocardiographic changes or angina. At follow-up, patient is well without any chest pain during daily activities.
PENGEMBANGAN WEBSITE SISTEM INFORMASI ADMINISTRASI KEPENDUDUKAN PADA KELURAHAN TUMBANG RUNGAN KOTA PALANGKA RAYA MENGGUNAKAN METODE WATERFALL

Field: Computer Science (Physical Sciences)

Tumbang Rungan sub-district in Palangka Raya manages population data as part of Population Administration, among others; Death Certificate, Certificate of Marriage / Marriage, Birth Certificate, Transfer Certificate, Disability Certificate, Building Construction Permit (IMB), Land and Building Tax, and Land Certificate. Currently there are still many government agencies that manually process population data, including Tumbang Rungan Village, Palangka Raya City, which still uses paper-based forms. If the listed requirements are incomplete, then the person concerned must go home / return first to complete the missing requirements, until they are sufficient and complete. This is very troublesome and wasteful of energy and other sacrifices. Kelurahan Tumbang Rungan, Palangkaraya City, plans to build a system that aims to assist the community in submitting information and receiving complaints by utilizing web facilities as well as monitoring the correspondence process (which is being processed or completed), and to enable the public to fill in data online. To overcome these problems, a study was made, website based with the stages of research divided into two stages, namely: (1) literature study and (2) software development by applying modified waterfall method which includes four steps namely system analysis, design, implementation and testing. For implementation using PHP in making program code and Mysql as a database to store data. Furthermore, software testing uses Blackbox testing
Reproduction rate and microbial load of the rotifer Brachionus calyciflorus (Pallas, 1766) fed on Chlorella sp. cultured on organic media

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract

An experiment was conducted to evaluate the culture performance and total microbial load of the rotifer Brachionus calyciflorus reared on microalgae Chlorella sp. cultured with a replacement of 50% of the standard Bolds’ Basal Medium (BBM) with poultry manure filtrate (POMF), sheep manure filtrate (SHMF), water hyacinth root compost filtrate (WHRCF), water hyacinth leaf compost filtrate (WHLCF), water hyacinth root and leaf compost filtrate (WHR + LCF) and a control treatment with 100% BBM. The results indicated that the POMF substituted culture of Chlorella sp. gave significantly highest cell density (1.83x108 cells mL− 1) followed by the 100% BBM culture (1.74x108 cells mL− 1) supporting 272 ± 6.4 and 122.2 ± 5.53 rotifers mL− 1 B. calyciflorus population, respectively. The SHMF culture gave the third highest Chlorella sp. density (5.94x107 cells mL− 1) and supports 83.4 ± 13.78 rotifers mL− 1 B. calyciflorus population. The three treatments with the compost filtrate of the different parts of water hyacinth gave the least Chlorella sp. cell density and B.calyciflorus population as well. In terms of the total viable bacterial count of B.calyciflorus cultured on the substitution of the different organic media indicated that B.calyciflorus cultured on 100% BBM and 50% POMF- based culture gave significantly lowest total bacterial counts of 6.9x106 ± 9.9x105 and 8.05x106 ± 4.94x105 CFU mL− 1, respectively while SHMF, WHR + LCF, WHLCF, WHRCF group showed higher total bacterial counts of 1.62x107 ± 2.83x105, 1.09x107 ± 7.78x105, 1.25x107 ± 7.07x104, 1.03x107 ± 7.07x104 CFU mL− 1, respectively in non-rinsed samples. Therefore, it can be concluded that 50% substitution the standard BBM media for Chlorella sp. culture with organic manures such as POMF can be a sustainable alternative to culture the rotifer B. calyciflorus for larval fish culture.
[Again on postcoital contraception].

Field: Medicine (Health Sciences)

Because of the adverse effects of combined hormonal contraceptives and the need for suitable contraceptives for young women and those who engage in unplanned sexual activity without contraceptives there has been in increased interest in postcoital contraception. The following 2 methods of postcoital contraception were recommended by the IPPF Advisory Panel. Hormone tablets containing 50 mg of ethinylestradiol and .25 mg levonorgestrel. 2 tablets to be administered in later than 72 hours after coitus and 2 additional tablets 12 hours later. This method should be used only in emergency situations such as condom failure or rape. The pregnancy rate with this method is between 0% and .16%. Insertion of a copper-impregnated IUD within 5 days after coitus and before day 19 or 20 of the menstrual cycle. Risks associated with the postcoital IUD use include collapse and adnexitis and its use should be limited to nulliparous women. There has been in incident of pregnancy reported in this method. Because postcoital contraception is important in emergency situations is should be readily available and physicians should be informed of its use.
Gender and Homelessness

Field: Social Sciences (Social Sciences)

Gender and Homelessness Get access Jan L. Hagen Jan L. Hagen Jan L. Hagen, Ph.D., is Assistant Professor, School of Social Welfare, Nelson A. Rockefeller College of Public Affairs and Policy, State University of New York at Albany, 135 Western Avenue, Albany, NY 12222. This article was presented at the 1986 NASW National Conference on Women's Issues, Atlanta, Georgia, May 28–31, 1986. Search for other works by this author on: Oxford Academic PubMed Google Scholar Social Work, Volume 32, Issue 4, July-August 1987, Pages 312–316, https://doi.org/10.1093/sw/32.4.312 Published: 01 July 1987 Article history Accepted: 04 December 1986 Published: 01 July 1987
Targeting P21-activated kinase suppresses proliferation and enhances chemosensitivity in T-cell lymphoblastic lymphoma

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

T-cell lymphoblastic lymphoma (T-LBL) is a highly aggressive non-Hodgkin lymphoma with a poor prognosis. P21-activated kinase (PAK) is a component of the gene expression-based classifier that can predict the prognosis of T-LBL. However, the role of PAK in T-LBL progression and survival remains poorly understood. Herein, we found that the expression of PAK1 was significantly higher in T-LBL cell lines (Jurkat, SUP-T1, and CCRF-CEM) compared to the human T-lymphoid cell line. Moreover, PAK2 mRNA level of 32 relapsed T-LBL patients was significantly higher than that of 37 cases without relapse ( P = .012). T-LBL patients with high PAK1 and PAK2 expression had significantly shorter median RFS than those with low PAK1 and PAK2 expression (PAK1, P = .028; PAK2, P = .027; PAK1/2, P = .032). PAK inhibitors, PF3758309 (PF) and FRAX597, could suppress the proliferation of T-LBL cells by blocking the G1/S cell cycle phase transition. Besides, PF could enhance the chemosensitivity to doxorubicin in vitro and in vivo. Mechanistically, through western blotting and RNA sequencing, we identified that PF could inhibit the phosphorylation of PAK1/2 and downregulate the expression of cyclin D1, NF-κB and cell adhesion signaling pathways in T-LBL cell lines. These findings suggest that PAK might be associated with T-LBL recurrence and further found that PAK inhibitors could suppress proliferation and enhance chemosensitivity of T-LBL cells treated with doxorubicin. Collectively, our present study underscores the potential therapeutic effect of inhibiting PAK in T-LBL therapy.
Genotype, extrapyramidal features, and severity of variant ataxia-telangiectasia.

Field: Medicine (Health Sciences)

OBJECTIVE: Variant ataxia-telangiectasia is caused by mutations that allow some retained ataxia telangiectasia-mutated (ATM) kinase activity. Here, we describe the clinical features of the largest established cohort of individuals with variant ataxia-telangiectasia and explore genotype-phenotype correlations. METHODS: Cross-sectional data were collected retrospectively. Patients were classified as variant ataxia-telangiectasia based on retained ATM kinase activity. RESULTS: The study includes 57 individuals. Mean age at assessment was 37.5 years. Most had their first symptoms by age 10 (81%). There was a diagnostic delay of more than 10 years in 68% and more than 20 years in one third of probands. Disease severity was mild in one third of patients, and 43% were still ambulant 20 years after disease onset. Only one third had predominant ataxia, and 18% had a pure extrapyramidal presentation. Individuals with extrapyramidal presentations had milder neurological disease severity. There were no significant respiratory or immunological complications, but 25% of individuals had a history of malignancy. Missense mutations were associated with milder neurological disease severity, but with a higher risk of malignancy, compared to leaky splice site mutations. INTERPRETATION: Individuals with variant ataxia-telangiectasia require malignancy surveillance and tailored management. However, our data suggest the condition may sometimes be mis- or underdiagnosed because of atypical features, including exclusive extrapyramidal symptoms, normal eye movements, and normal alpha-fetoprotein levels in some individuals. Missense mutations are associated with milder neurological presentations, but a particularly high malignancy risk, and it is important for clinicians to be aware of these phenotypes. ANN NEUROL 2019;85:170-180.
Synergizing Industry 4.0 Technology With Additive Manufacturing to Enhance Quality Assurance and Enable Additive Manufacturing As a Service Industry

Field: Engineering (Physical Sciences)

Abstract The widespread adoption of additive manufacturing (AM), also known as 3D printing, highlights the importance of maintaining stringent quality standards in 3D-printed parts. This work introduces an innovative approach integrating Industry 4.0 with AM, focusing on harnessing the Internet of Things (IoT) for feedback control to swiftly detect defects. Operating within the framework of AM as a service (AMaaS), the system efficiently manages multiple 3D printers to meet client demands. Utilizing Raspberry Pi (RPi) and advanced Python socket modules, a user-friendly graphical interface (GUI) enriched with live video streams enhances user interaction. Clients can securely upload STL files over the Internet, accessing the system via robust authentication mechanisms. Live video feeds from RPi high-quality (HQ) cameras offer real-time insights into the printing process, while a deep learning (DL)-based convolutional neural network (CNN) model accurately detects warpage defects. Trained on images captured by RPi cameras, the CNN model’s performance metrics are systematically explored. This research integrates Industry 4.0 principles with 3D printing, advancing AMaaS with proactive quality control and live monitoring, showcasing innovative DL-based defect detection. The framework contributes to smart AM practices, promising widespread applicability across industries.
A COMPARATIVE STUDY ON THE PASSIVITY OF THE STUDENTS LEARNING ENGLISH AS A SECOND LANGUAGE AT ALEKSANDRAS STULGINSKIS UNIVERSITY

Field: Arts and Humanities (Social Sciences)

The article focuses on the comparative analysis of the causative factors influencing the students’ passivity in 2005 and 2017 as well as on classwork methods stimulating their activity. The analysis was based on the results obtained in 2005 and 2017. The results showed that the main reasons of the students’ passivity in 2005 during their English classes was their habit to be silent acquired in the high school as well as their unwillingness to show emotions (female approach) and laziness (male approach). In 2017 the students were still unwilling to show their emotions (both female and male approach) and laziness (male approach). In 2005 the active students pointed out discussion as the most acceptable method to acquire competence in the English as the second language, whereas the passive students preferred teamwork to any other classroom activity. Both target groups emphasized the importance of good psychological climate during the classes. In 2017 discussion was found to be the most acceptable method to acquire competence and better speaking skills for the both active students and passive students, while the latter indicated that the psychological climate during the classes as exceptionally important helping them to cope with the stress and language barrier. The obtained results also showed that the students in 2017 were more conscious of the importance of being active during the classes.
What roles does accounting play in the fight against corruption? Insights from a systematic literature review

Field: Business, Management and Accounting (Social Sciences)

The fight against corruption has become a priority for both international organizations and national governments worldwide. To fight corruption, several strategies have been suggested which enlist accounting because of its natural orientation towards information disclosure, integrity systems, and efficiency. This article presents a comprehensive literature review regarding accounting vis-à-vis corruption in the public sector. The review combines a bibliometric and a qualitative analysis. The findings reveal a highly fragmented field of research, with no consolidated networks of scholars. The conceptual structure of the field consists of five main themes, corresponding to different strategies through which accounting can contribute towards fighting corruption. Accounting assemblages, however, may not fulfil expectations and were found to play a wide spectrum of roles, ranging from an effective prevention of corruption to active complicity with it. These roles are affected by individual, organizational, and external variables. The article concludes by outlining several avenues for future research.
Long Run Profit Maximization in Turkish Manufacturing Sector

Field: Economics, Econometrics and Finance (Social Sciences)

The equilibrium concept is the most important subject for economic theory. The importance of this concept arises in determination of functional structures of the economic variables. Jenkinson (1986) has estimated the long term labour demand function and rationalisation mechanism by using co-integration technique. By focusing on different aspects of rationalisation mechanism in the long run and time series econometrics in formulating and testing this relationship, ACMS (Arrow, Chenery, Minhas, Solow), CES (Constant Elasticity of Substitution) Production Function and co-integration technique are to be employed in this research in particular. The purpose of this research is to investigate whether the long-run equilibrium implied by profit maximization is valid for the Turkish manufacturing industry for the period of 1950-2001 or not. During this period, Turkish economy has undergone important structural changes, for example the implementation of liberalization policies after 1980s. Thus, the possible effects of economic policy implementation over the profit maximization in the Turkish Manufacturing sector will also be studied by using new time series techniques such as Zivot and Andrews(1992) unit root test and Gregory-Hansen (1996) co-integration tests. Because most of the previous studies about this issue are concentrated in developed countries and there has been little research on Turkish manufacturing sector, this study’s contribution is important.