jimnoneill/paper-to-field-training huggingface dataset:
[Analysis of changes in peripheral and central nervous system in irregularly treated adult patients with primary congenital hypothyroidism].

Field: Medicine (Health Sciences)

Changes in the nervous system were found in 72% of respondents. Patients who had implemented replacement therapy L-thyroxine after completing 12 months of age showed the most neurological disorders. There were variations in the cranial nerves III, IX, IV and VI. In 34% of respondents revealed paraneoplastic cerebellar symptoms, while the pyramid, and extrapyramidal symptoms in 10% and 3% of the people. EEG showed changes in brain bioelectrical activity in the entire study group. In the 83% found a significant asymmetry in regional cerebral blood flow (rCBF). Hypoperfusion outbreak occurred mainly in the stands and leading occipital. The relationship between time of initiation of treatment, and the presence of a systematic change in the nervous system was inversely proportional. In turn, analyzing the causes of most PCH deviations were found in the nervous system in patients with athyreosis. Brain SPECT study in these patients confirmed the organic changes in brain development. CONCLUSIONS. The presence and extent of changes in peripheral and central nervous system depends on the cause PCH, pending the implementation of L-thyroxine treatment and systematic. Studies of brain SPECT and EEG confirmed the existence of developmental changes of the brain in patients with PCH.
Prognostic Value of Serum Cardiac Troponin T and Nitric Oxide as Cardiac Biomarkers in Pregnancy Toxemic Goats

Field: Veterinary (Health Sciences)

4 Abstract: Pregnancy toxemia (PT) is a metabolic disorder occurring in goats during the late stage of gestation. The importance of cardiac troponin T (cTnT) and nitric oxide (NO) concentration as cardiac biomarkers in pregnancy toxemia has been emphasized in several diseases. However, its prognostic value in PT has not been examined. The aim of this study is to determine the prognostic value of cTnT and NO in PT goats. Twenty clinically affected goats (10 with early PT and 10 with advanced PT, along with 20 clinically healthy goats (10 pregnancies and 10 non pregnant) were used in this investigation. Goats with early toxemia had anorexia, depression, dullness, pronounce acetone odor from mouth and scanty feces. Additionally, recumbency, muscular tremors, grinding of teeth and deviated head and neck were noticed in advanced PT goats. All does with advanced PT not respond to any type of treatment. Liver function tests (ALT& AST), kidney function tests (blood urea nitrogen and creatinine), cardiac function parameters (cTnT and NO) beside the glucose and HB showed a significant increase as the disease progressed. Elevation of cTnT and NO considered a bad prognostic marker in goats with PT, especially when reached at level 19-20 folds and 3-4 folds, respectively. The results of this study suggest that the elevation of cTnT and NO indicating cardiac insufficiency, which considered a strong prognostic marker in PT goats and can be used for monitoring animal health.
A Simple Biorefinery Concept to Produce 2G-Lactic Acid from Sugar Beet Pulp (SBP): A High-Value Target Approach to Valorize a Waste Stream

Field: Chemical Engineering (Physical Sciences)

Lactic acid is a high-value molecule with a vast number of applications. Its production in the biorefineries model is a possibility for this sector to aggregate value to its production chain. Thus, this investigation presents a biorefinery model based on the traditional sugar beet industry proposing an approach to produce lactic acid from a waste stream. Sugar beet is used to produce sugar and ethanol, and the remaining pulp is sent to animal feed. Using Bacillus coagulans in a continuous fermentation, 2781.01 g of lactic acid was produced from 3916.91 g of sugars from hydrolyzed sugar beet pulp, with a maximum productivity of 18.06 g L−1h−1. Without interfering in the sugar production, ethanol, or lactic acid, it is also possible to produce pectin and phenolic compounds in the biorefinery. The lactic acid produced was purified by a bipolar membrane electrodialysis and the recovery reached 788.80 g/L with 98% w/w purity.
Optimization of Supply Chain Workflow in Food Industry

Field: Decision Sciences (Social Sciences)

Maintaining the freshness of perishable items like cheese is essential especially for restaurant business. This research is aimed at solving a problem of the restaurant and improving the workflow of the restaurant. Based on the historical sales data, the pizza sales for the next day is predicted, the Cheddar cheese used for making the pizza is calculated using forecasting methods Auto Regressive Integrated Moving Average (ARIMA) and TBATS. The performance of both the models are compared using different evaluation parameters where ARIMA outperformed TBATS and used to forecast the sales for the next day. An automated email system is created for sending the notification to the owner of the restaurant stating the quantity of cheese required for the next day. Based on the results obtained, this research can be deployed in the real world for solving the limited space constraints and providing timely information to the restaurant owner.
Clinical experience with cefoxitin sodium

Field: Medicine (Health Sciences)

Cefoxitin sodium was evaluated in 48 patients having respiratory tract (20 patients), urinary tract (8 patients), and soft-tissue (4 patients) infections and septicaemia (16 patients). Clinical cure was achieved in 38 patients: 18 of 20 respiratory tract; 4 of 8 urinary tract; 13 of 16 septicaemia, and 3 of 4 soft-tissue infections. Twenty infections were resistant to cephalothin; 14 of these were cured by cefoxitin, which is also active against strains resistant to cefamandole, cefuroxime, gentamicin and amikacin. Cefoxitin was found effective against Gram-negative bacteria, including Bacteroides fragilis , indole-positive Proteus and Serratia . Cefoxitin was well tolerated. Few side effects, none serious, were encountered.
Organizational and Human Factors in Green Medical Informatics – A Case Study in Dutch Hospitals

Field: Health Professions (Health Sciences)

Medical Informatics brings methods and solutions that could support reducing healthcare’s ecological footprint. Initial frameworks for Green Medical Informatics solutions are available, however these do not address organizational and human factors. Including these factors in evaluation or analysis of (technical) interventions aimed at making healthcare more sustainable, is essential for improving usability as well as effectiveness of these interventions. Interviews with healthcare professionals from Dutch hospitals led to preliminary insights into which organizational and human factors impact the implementation and adoption of sustainable solutions. Results indicate that forming multi-disciplinary teams is considered an important factor for realizing intended outcomes in terms of reducing carbon emissions and waste. Some other key factors mentioned are formalizing tasks, allocating budget and time, creating awareness and changing protocols to promote sustainable diagnosis and treatment procedures.
Application of a “Continuous‐Acquisition‐Method” to potassium isotope measurements by multi‐collector inductively coupled plasma mass spectrometry

Field: Chemistry (Physical Sciences)

Rationale The very small mass difference between 41 K and 40 ArH + makes the flat, hydride interference‐free peak shoulders very narrow (0.002–0.003 m/z unit), bringing a number of analytical challenges when measuring K isotopic compositions by multi‐collector inductively coupled plasma mass spectrometry (MC‐ICP‐MS). In traditional Sequence Run mode, the parameters are loaded every line of the sequence which can introduce tiny drifts of tune parameters and mass peaks. This may occasionally lead to the failure of K isotope measurements when mass drifts exceed 0.002 m/z unit. It is thus essential to keep the tune parameters, especially the magnet current, very stable to achieve high‐precision K isotopic compositions. Method We developed a “Continuous‐Acquisition‐Method” (CAM) MC‐ICP‐MS Run mode to improve the stability when determining K isotopes. Two sets of experiments were designed: (a) Stability test: measuring a single pure K solution (viz. NIST‐999c) for ~3 h and comparing the stability of the two run modes; and (b) GSB‐K test: measuring our inhouse pure K standard solution (GSB‐K) in both run modes and comparing the accuracy and precision. Results The traditional Sequence Run mode only kept the MC‐ICP‐MS system stable for the first ~1.5 h during the ~3‐h test, with an offset of the mass peaks of ~0.003 m/z unit. The CAM Run mode yielded higher stability during the whole test (~3 h), with a peak shift <0.0004 m/z unit. Measurement of the GSB‐K standard solution in Sequence Run and CAM Run modes gives identical δ 41 K values when the magnet was kept stable, with the CAM Run mode offering a better precision and keeping the instrument stable for longer time. Conclusions The MC‐ICP‐MS CAM Run mode shows higher stability and better precision. It is, therefore, good for high‐precision K isotope measurements.
[Leptospirosis].

Field: Medicine (Health Sciences)

Leptospirosis is a zoonosis caused by pathogenic Leptospira species. Leptospira infection can range from subclinical to life-threatening disease. Renal failure and severe respiratory symptoms may occur and are associated with a high mortality rate. It is important to realise that renal failure and other symptoms can occur in the absence of icterus. Leptospiraemia occurs mostly during the first week of acute illness, so blood cultures should be taken as soon as possible. Most cases of leptospirosis are diagnosed by serology. Antibodies are detectable in the blood approximately 5 to 7 days after onset of symptoms. Early recognition and treatment with either cephalosporins or penicillin may shorten the duration and severity of multi-organ failure and is therefore mandatory.
EXAMINATION OF MINUTE CANCER OF THE THYROID GLAND

Field: Medicine (Health Sciences)

Twenty-two cases of minute cancer of the thyroid gland experienced at our department for a recent 12 years were retrospectively studied. Minute cancers accounted for 23.7% of all operated thyroid cancers. Of the 22 cases 3 had multiple tumors, and the subjected tumors counted 25. These tumors were found by metastasis to the cervical lymph node in one case, and by medical examination in 21 cases. Calcification was seen in 45.5% of the cases by soft ray radiography. Ultrasonic examination performed on 23 tumors in 20 cases revealed irregular margine in 13 tumors, acoustic shadow lacking in internal echo in 19, and unidentified in one. Histologically there were 24 papillary carcinomas and one follicular carcinoma. Operative procedures included total thyroidectomy in 3, subtotal thyroidectomy in 19, and lymph node dissection in 22 cases which comprised modified neck dissection (MND) on the affected side in 16, lymph node dissection (I-IV) alone in 3, and bilateral MND in 3.Excepting multiple cancer cases undergone bilateral lymph node dissection, 16 MND cases were examined, and lymph node metastasis was seen in 60% of tumors in the isthmus which were all in group I-IV. While the metastasis was seen in 66.7% of tumors in the flocculus of which 50% were in group V-VII. In an avaraged observation period of 20.7±15.1 months, recurrence in the lymph nodes occurred in 4.5% of the cases.
Studies on Bermuda grass pollen allergens.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Two allergens, BGP-1 and BGP-2, were identified in crude Bermuda grass pollen extract. BGP-1 was a major allergen and elicited a skin reaction in all subjects sensitive to the crude extract, whereas BGP-2 was a minor allergen and elicited a reaction in only 75% of such subjects. Calibrated column chromatography was used to determine the molecular weights and Stokes radii of the allergens. For BGP-1 they were 30 000 daltons and 24,3 X 10(-8) cm respectively and for BGP-2 they were 14 000 daltons and 18,1 X 10(-8) respectively. The sedimentation coefficient (S20,w) of BGP-1 on sucrose density gradient ultracentrifugation was 3,1 and on iso-electric focusing its iso-electric point was found to be pH 5,4. The reason why only certain individuals sensitive to BGP-1 are sensitive to BGP-2 is discussed. It is possible that the former is a dimer of the latter.
Effects of post annealing on IZO thin-film transistor characteristics

Field: Materials Science (Physical Sciences)

We studied how post-annealing process affects the transparent thin-film transistor (TFT) characteristics. Polycrystalline indium zinc oxide layer deposited by rf magnetron sputtering on an unheated glass substrate was used for the active channel layer. The post annealing was conducted for 30 minutes by varying ambient gases and temperature. At annealing temperature of 450°C, the threshold voltage was shifted from -12 V to 0 V. Also, transconductance (g m ) was improved by one order of magnitude. Structural dependence was also examined for top-gate structures with or without gate electrode overlap with sauce electrode.
Challenges in microstructural metrology for advanced engineered materials

Field: Materials Science (Physical Sciences)

Measurement of microstructural parameters is essential for both controlling and modelling properties of and production processes for advanced materials. In the past decade new techniques such as electron backscatter diffraction have enabled a considerable increase in the amount of data and degree of detail in microstructural measurements of, for example, the extent of recrystallization in a metal deformed at high temperatures. However, the many parameters involved and automated nature of the methods can lead to artefacts and bias in calculated values, and increased resolution will lead to disagreement with more conventional methods. Examples are given of the range of microstructural measurements possible by new techniques and how different results can be obtained from the same underlying data. The need is stressed for interlaboratory comparisons to enable underpinning data to be derived on the validity, repeatability and reproducibility of measurements of key microstructural parameters.
Monkeypox in Bulgaria: Significance of Various Clinical Samples, Clinical Manifestation, and Molecular Detection

Field: Medicine (Health Sciences)

Background/Objectives: Monkeypox (mpox) is currently the most common orthopoxvirus (OPXV) zoonotic disease, and, since 2022, there has been atypical person-to-person transmission observed in non-endemic countries. The present study aimed to investigate the frequency of monkeypox virus (MPXV) and OPXV DNA detection in recommended and alternative clinical materials taken during the acute and convalescent phases of infection in Bulgarian patients. Methods: The study included laboratory investigation by real time PCR of 181 clinical samples from 42 Bulgarian patients with possible mpox infections. Results: MPXV DNA was detected in 23/181 (12.71%), and OPXV DNA in 20/181 (11.05%) clinical samples. There were six mpox-confirmed patients aged 23 to 44. At the highest frequency, MPXV and OPXV DNA were detected in samples of vesicular contents (6/6) and nasal/oropharyngeal secretions (5/6 and 4/6) during the first three days from the appearance of clinical symptoms. We demonstrated MPXV and OPXV DNA in alternative samples (urine, feces, ejaculate, and saliva), and in follow-up patient samples, taken two weeks after mpox confirmation in the convalescent phase (vesicular contentsand urine). Conclusions: Our findings suggested that MPXV may be detected in a larger set of clinical materials, including alternatives, where the virus can persist for more than two weeks.
Prevalence and clinical significance of the positive antinuclear antibody in children with idiopathic thrombocytopenic purpura

Field: Medicine (Health Sciences)

Purpose : An association between idiopathic thrombocytopenic purpura (ITP) and systemic lupus erythematosus (SLE) has been recognized for decades because thrombocytopenia is the first manifestation in some patients with SLE. However, the risk of later development of SLE in childhood ITP is currently unknown. We retrospectively evaluated the incidence and clinical significance of the positive antinuclear antibody (ANA) in children with acute ITP. Methods : This study was retrospectively performed to review the clinical and laboratory characteristics in 77 children diagnosed to have acute ITP and admitted to the Pusan National University Hospital between January 2003 and December 2006. Patients tested positive for ANA were regularly followed-up for at least 12 months for symptoms indicative of SLE. Results : Seventy-seven children were included in the study; 38 males (49.4%) and 39 females (50.5%), the mean age was 4.5 years. Sixteen (20.8%) ITP patients had a positive ANA, with a median titer of 1:320. The mean age of the patients with positive ANA was 9.3 years, which is much older than 3.3 years for patients with negative ANA (P
Sphingolipidoses and Related Disorders

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Sphingolipids are a large and complex class of lipids with an essential structural role as major components of the cell membrane and also have important cell signaling functions. This chapter discusses genetic defects leading to neurological manifestations. Biochemical and genetic diagnosis of sphingolipids are carried out in specialized laboratories. Two main strategies have been used to correct sphingolipid deficiencies. The first strategy is reduction of substrate levels either by removal of storage material or by reducing its production. The second strategy is complementation strategies including hematopoietic stem-cell allotransplantation, enzyme replacement therapy, pharmacological chaperone therapy, gene therapy and cell-based therapy. Both GM1 gangliosidoses and mucopolysaccharidoses (MPS) IVB are called allelic GLB1-related disorders, in which pathogenic variants in the GLB1 gene impair the activity of ß-galactosidase towards its substrate glycosphingolipid GM1 and/or keratan sulfate. GM2 gangliosidoses are autosomal recessive lysosomal storage disorders resulting in motor and mental deterioration due to massive accumulation, mainly in neurons.
Performance Measures in Supply Chains

Field: Decision Sciences (Social Sciences)

Interest in supply chain management (SCM) has increased as organisations seek opportunities to improve performance. Monitoring plays a key role in enhancing supply-chain performance by highlighting opportunities for improvements. However, evidence on the use of performance measures in SCM is scant. This paper explains the role of performance measures in SCM, and the difficulties in their design and implementation. The paper discusses frameworks for the development of supply chain performance measures, and presents case studies of performance measurement in Australian supply chains.
Early treatment of myocardial infarction in the community.

Field: Medicine (Health Sciences)

The prehospital management of acute myocardial infarction by general practitioners and emergency-treatment service physicians was analysed in 53 patients. The correct clinical diagnosis was made or suggested before admission in 47 patients. Only 25 patients received analgesics from the general practitioner, and 32 were still in pain and needed diamorphine on admission to hospital. Only one patient received antiarrythmic treatment. The findings suggest that, despite accurate clinical diagnosis of acute myocardial infarction, deficiencies exist in the prehospital phase of management and that education programmes are worth consideration.
Entrepreneurial orientation and SME international performance: The mediating role of networking capability and experiential learning

Field: Business, Management and Accounting (Social Sciences)

This article extends knowledge of entrepreneurial orientation (EO) by examining EO in the context of international performance of small- and medium-sized enterprises (SMEs). We enhance understanding of foreign market entry of SMEs by taking into account the mediating mechanisms (i.e. networking capability and experiential learning) through which firm EO leads to superior performance across borders. A sample of 164 internationalising SMEs in New Zealand supported the direct impact of EO on international performance as well as the mediating role of experiential learning and networking capability in this focal relationship. These findings reveal the importance of EO in internationalisation of SMEs.
Pharmacy technician’s vigilance spurs drug recall

Field: Health Professions (Health Sciences)

Journal Article Pharmacy technician’s vigilance spurs drug recall Get access Kate Traynor Kate Traynor Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 72, Issue 17, 1 September 2015, Pages 1428–1430, https://doi.org/10.2146/news150058 Published: 01 September 2015
Effects of ICI 182,780, an ERα and ERβ antagonist, and G-1, a GPER agonist, on autophagy in breast cancer cells

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

ABSTRACT Objective To investigate if ICI 182,780 (fulvestrant), a selective estrogen receptor alpha/beta (ERα/ERβ) antagonist, and G-1, a selective G-protein-coupled receptor (GPER) agonist, can potentially induce autophagy in breast cancer cell lines MCF-7 and SKBr3, and how G-1 affects cell viability. Methods Cell viability in MCF-7 and SKBr3 cells was assessed by the MTT assay. To investigate the autophagy flux, MCF-7 cells were transfected with GFP-LC3, a marker of autophagosomes, and analyzed by real-time fluorescence microscopy. MCF-7 and SKBr3 cells were incubated with acridine orange for staining of acidic vesicular organelles and analyzed by flow cytometry as an indicator of autophagy. Results Regarding cell viability in MCF-7 cells, ICI 182,780 and rapamycin, after 48 hours, led to decreased cell proliferation whereas G-1 did not change viability over the same period. The data showed that neither ICI 182,780 nor G-1 led to increased GFP-LC3 puncta in MCF-7 cells over the 4-hour observation period. The cytometry assay showed that ICI 182,780 led to a higher number of acidic vesicular organelles in MCF-7 cells. G-1, in turn, did not have this effect in any of the cell lines. In contrast, ICI 182,780 and G-1 did not decrease cell viability of SKBr3 cells or induce formation of acidic vesicular organelles, which corresponds to the final step of the autophagy process in this cell line. Conclusion The effect of ICI 182,780 on increasing acidic vesicular organelles in estrogen receptor-positive breast cancer cells appears to be associated with its inhibitory effect on estrogen receptors, and GPER does notseem to be involved. Understanding these mechanisms may guide further investigations of these receptors’ involvement in cellular processes of breast cancer resistance.