jimnoneill/paper-to-field-training huggingface dataset:
Biological activity of some thyrotrophin-releasing hormone analogues substituted at the 2 position

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Conference Article| June 01 1990 Biological activity of some thyrotrophin-releasing hormone analogues substituted at the 2 position RORY MITCHELL; RORY MITCHELL 1M.R.C. Brain Metabolism Unit, University Department of Pharmacology, 1 George Square, Edinburgh EH8 9JZ, U.K. Search for other works by this author on: This Site PubMed Google Scholar DAVID MacEWAN; DAVID MacEWAN 1M.R.C. Brain Metabolism Unit, University Department of Pharmacology, 1 George Square, Edinburgh EH8 9JZ, U.K. Search for other works by this author on: This Site PubMed Google Scholar MELANIE JOHNSON; MELANIE JOHNSON 1M.R.C. Brain Metabolism Unit, University Department of Pharmacology, 1 George Square, Edinburgh EH8 9JZ, U.K. Search for other works by this author on: This Site PubMed Google Scholar LYNNE DOUGAN; LYNNE DOUGAN 1M.R.C. Brain Metabolism Unit, University Department of Pharmacology, 1 George Square, Edinburgh EH8 9JZ, U.K. Search for other works by this author on: This Site PubMed Google Scholar CHRISTINE BLADON CHRISTINE BLADON 1M.R.C. Brain Metabolism Unit, University Department of Pharmacology, 1 George Square, Edinburgh EH8 9JZ, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: November 23 1989 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1990 Biochemical Society1990 Biochem Soc Trans (1990) 18 (3): 433–434. https://doi.org/10.1042/bst0180433 Article history Received: November 23 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation RORY MITCHELL, DAVID MacEWAN, MELANIE JOHNSON, LYNNE DOUGAN, CHRISTINE BLADON; Biological activity of some thyrotrophin-releasing hormone analogues substituted at the 2 position. Biochem Soc Trans 1 June 1990; 18 (3): 433–434. doi: https://doi.org/10.1042/bst0180433 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: TRH. thyrotrophin-releasing hormone, pGla. pyroglutamyl, 3-McHis, 3-methylhistidyl, Nval. norvalyl This content is only available as a PDF. © 1990 Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Quantization of Pinus forest biophysical parameters using WorldView-2

Field: Environmental Science (Physical Sciences)

Numerous studies have used various types of remotely sensed data to estimate forest biomass-related parameters such as basal area, volume, biomass, stocking etc. Some sensors have high spectral resolution such as ASTER or MODIS, but low spatial resolution whereas others have high spatial resolution, but low spectral information, such as IKONOS and QuickBird. Digital Globe’s WorldView-2 provides a combination of high spatial resolution with 8 spectral bands, some of which are new and require investigation for estimation of forest structure parameters. In this study, we have applied various textural and spectral indices extracted from WorldView-2 data to estimate plot-level basal area, volume, mean height and mean diameter at breast height (DBH) over a Pinus radiata plantation in New South Wales, Australia. The results showed that estimates of mean height and DBH with acceptable accuracy whereas the results for volume and basal area were less promising. Moreover, it was shown that the red edge, yellow and NIR2 bands can perform efficiently in combination or individually for estimation of biophysical parameters. 1.
CAPITAL PUNISHMENT FOR DRUGS TRAFFICKING IN SOUTHEAST ASIA: A VIOLATION OF HUMAN RIGHTS LAW?

Field: Social Sciences (Social Sciences)

International law does not specifically prohibit states imposition of capital punishment, but its restriction is arranged by Article 6(2) of the International Covenant on Civil and Political Rights. The article specifically states that “[…] death sentence may be imposed only for the most serious crimes by the law in force.” According to a report produced by Harm Reduction International under a grant from the European Commission, from 2000 onwards more states have revoked capital punishment for all crimes, and others have eradicated the sentence as a possible punishment for drugs. This is partly because there is a rising argument that capital punishment for drugs is a violation of international human rights law. Whereas abolitionist norms have become a global trend, the death penalty, especially on drugs trafficking case, is still practiced in Southeast Asia nations: Indonesia, Singapore, Malaysia, Vietnam and Philippine. The paper challenges constructivist beliefs that international norms wield over state’s policy by taking a closer look at the validity of death penalty for drugs traffickers.Keywords: death penalty, drugs, trafficking, international law, Southeast Asia
The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The cbl oncogene was first identified as part of a transforming retrovirus which arose in a mouse pre-B cell lymphoma. Its protein product, p120cbl, is cytoplasmic and has several distinctive domains including a highly basic region, a RING finger motif and a large proline-rich domain. A mutation to cbl in the 70Z/3 pre-B cell lymphoma produces an oncogenic protein which exhibits a marked enhancement of tyrosine phosphorylation. Parallel studies have demonstrated that p120cbl is a substrate of protein tyrosine kinases activated by engagement of the T cell antigen receptor and that cbl is phosphorylated by oncogenic forms of the Abl tyrosine kinase. A genetic analysis of the Caenorhabditis elegans cbl homologue, sli-1, demonstrates that sli-1 negatively regulates the LET-23 tyrosine kinase receptor. Here we show that p120cbl is rapidly phosphorylated on tyrosine residues following EGF stimulation and that it forms an inducible complex with the receptor. Our results also show that the oncogenic 70Z/3 form of cbl has enhanced binding to the EGF receptor and that peptides spanning the proline-rich region bind a range SH3 domains. These findings are consistent with a conserved role for cbl/sli-1 proteins in mammals and nematodes.
Effect of losartan combined with amlodipine or with a thiazide on uric acid levels in hypertensive patients

Field: Medicine (Health Sciences)

Hyperuricemia leads to endothelial dysfunction and insulin resistance, and has been associated with diseases such as hypertension. Antihypertensive drugs modify serum uric acid levels, however, few data are available about their combinations on uricemia. In this study we evaluate the effect of two combinations of losartan, with amlodipine or with hydrochlorothiazide, on serum uric acid levels in hypertensive patients. Methods: A total of 60 hypertensive patients were randomized in two groups; group LA received losartan/amlodipine (100/5 mg) once a day, whereas LH group received losartan hydrochlorothiazide (100/12.5 mg) once a day for 3 months. In both groups serum uric acid levels were measured at the beginning and end of the study. Patients were evaluated monthly for blood pressure (BP) and adverse events. Statistical analysis was performed with a two-way analysis of variance (ANOVA) for repeated measures. Results: All patients experienced a significant reduction of BP to the same extent (LA 155/94 to 123/79, LH 157/92 to 124/78 mmHg, p > 0.05). In the LA group, serum uric acid decreased from 6.5 ± 1.6 to 4.6 ± 1.3 mg/ml ( p = 0.0001), whereas in the LH group there was a nonsignificant increase from 5.82 ± 1.4 to 5.85 ± 1.5 mg/ml, ( p = 0.936). When both groups were compared, we found a significant reduction ( p < 0.00013) on serum uric acid levels in the LA group. Conclusions: Both combinations decrease BP values to the same extent, however, LA combination showed a reduction on serum uric acid levels, which may contribute to a reduction in the metabolic risk in hypertensive patients.
Extending a Short-range Wireless Instrumentation Bus to a Geographic Network

Field: Engineering (Physical Sciences)

In this paper, important enhancements to a wireless instrumentation bus based, on Bluetooth (BT) standard, are presented. They concern with the realization of a slave Bluetooth module for USB devices and the possibility to control the wireless instrumentation bus via remote Ethernet controllers. In the paper, wide descriptions of the realized improvements are presented. Finally results of the whole interface system characterization in terms of communication reliability and throughput are reported with reference to some basic operation modes
EFFICACY OF THREE MERIDIAN FORMULATIONS AGAINST JAPANESE BEETLE, 2001

Field: Agricultural and Biological Sciences (Life Sciences)

This trial was conducted on a lawn at Campbell's Scottish Highlands Golf Course, Salem, NH.Test plots were 49 ft 2 , replicated five times, in an RCB design.All treatments were applied 18 Jul.The dry granular treatment was applied using large saltshakers.Liquid treatments were applied using a 7-ft boom on a twowheel bicycle-type sprayer, equipped with four 8005 nozzles, fitted with 50-mesh screens.The volume of water and insecticide mix was 2 gal/1,000ft 2 , delivered with CO 2 at 40psi.All treatments were hand watered to approximately 1/4 inch; the lawn was mowed every 3 days at 7/8 inch.There was no precipitation 24 h before or after application.Weather conditions at time of application were as follows: sky, cloudy; wind, less than 5 mph; air temperature, 64.4°F.Soil composition and conditions were as follows: texture, sandy loam; sand, 62%; silt, 31%; clay, 7%; pH, 6.6; organic matter, 7.6%; thatch depth, 0.38 inch; soil moisture, 18.4%; soil surface temperature, 71.6°F; at 1-inch depth, 70.5°F; at 2-inch depth, 69.3°F.The trial was rated for live grubs, 1-ft 2 section per plot, on 19 Sep.A Ryan sod cutter was used to cut the sod 12 inches wide and 2 inches deep.All grubs were identified to species; only JB grubs (the predominant species) were analyzed.
Iron status in diabetes mellitus

Field: Medicine (Health Sciences)

Diabetes mellitus can be defined as chronic metabolic disease which results from either relative or complete absence of insulin by the pancreatic beta islet cells. This in-turn may lead to hyperglycemia due to disturbances in the metabolism of glucose. In the human body, iron is con- sidered to be an effective pro-oxidant and participates in the generation of reactive oxygen species (ROS) such as hydroxyl radical. Because of the poor antioxidant defense mechanism of beta cells (low production of antioxidant enzymes such as catalase, glutathione peroxidase and dismutase), so they are highly prone to iron-induced oxidative stress and iron deposition in it and this will lead to apoptosis, and subsequently insulin deficiency. This iron deposition in beta cells will also lead to insulin resistance by reducing insulin extracting ability of the liver and inhibiting glucose uptake in muscle tissues and fats, this in turn will result in high production of hepatic glucose. Ferritin which is an acute phase reactant protein, that responds to acute stress like trauma, infections, tissue necrosis and surgery, it can produce diabetes mellitus either through inflammation or by increasing iron stores.
Range migrating target detection in correlated compound-Gaussian clutter

Field: Computer Science (Physical Sciences)

The problem of range-migrating target detection in a compound-Gaussian clutter is studied here. We assume a target to have a range-walk of a few range cells during the coherent processing interval, when observed by wideband radar with high range resolution. Two CFAR detectors are proposed assuming different correlation properties of clutter over range. The detectors' performance is studied via numerical simulations and a significant improvement over existing techniques is demonstrated.
Nordic-SADCC Cooperation

Field: Social Sciences (Social Sciences)

The Nordic-SADCC cooperation initiative is potentially an innovative attempt to generate new forms of economic interaction between a well defined group of developed and developing countries. The partners concerned are internationally almost extreme cases as regards their level of socio-economic development. The extended cooperation framework between the two groups of countries is, however, well justified. Both groups are geographically concentrated and have a tradition of mutual development cooperation. Their policies as a whole have a similar emphasis on poverty alleviation and development as well as the consistent condemnation of the South African apartheid regime. Issues related to international politics rather than vested economic interests have offered the driving force in the emergence of this cooperation attempt. Never theless, the initiative is at this stage based on already existing measures and institutions and has not yet introduced qualitatively new patterns of mutual interaction.
Study of the edge-field effect on the properties of plasmon modes in a graphene microribbon

Field: Physics and Astronomy (Physical Sciences)

The work devoted to theoretical studies of the excitation of plasmon modes in a graphene microribbon by an incident terahertz electromagnetic wave. The problem is solved in a three-dimensional formulation taking into account edge-field effects at the ends of graphene microribbon by using the integral equation method being developed by the authors. The influence of microribbon length (for constant width of the microribbon) on the properties of the fundamental plasmon mode is studied. Criteria for choosing either simplified two-dimensional or three-dimensional electromagnetic approaches for studying the properties of plasmon modes in graphene microribbons are formulated.
Polypharmacy, Medication Possession, and Deprescribing of Potentially Non-Beneficial Drugs in Hospice Patients

Field: Health Professions (Health Sciences)

Patients frequently have comorbidities that when combined with their primary diagnosis qualifies the patient for hospice. Consequently, patients are at risk for polypharmacy due to the number of medications prescribed to treat both the underlying conditions and the related symptoms. Polypharmacy is associated with negative consequences, including increased risk for adverse drug events, drug–drug and drug–disease interactions, reduced functional status and falls, multiple geriatric syndromes, medication nonadherence, and increased mortality. Polypharmacy also increases the complexity of medication management for caregivers and contributes to the cost of prescription drugs for hospices and patients. Deprescribing or removing nonbeneficial or ineffective medications can reduce polypharmacy in hospice. We study medication possession ratios and rates of deprescribing of commonly prescribed but potentially nonbeneficial classes of medication using a large hospice pharmacy database. Prevalence of some classes of potentially inappropriate medications is high. We report possession ratios for 10 frequently prescribed classes, and, because death and prescription termination are competing events, we calculate prescription termination rates using Cumulative Incidence Functions. Median duration of antifungal and antiviral medications is brief (5 and 7 days, respectively), while statins and diabetes medications have slow discontinuance rates (median termination durations of 93 and 197 days). Almost all patients with a proton pump inhibitor prescription have the drug for their entire hospice stay. Data from this study identify those drug classes that are commonly deprescribed slowly, suggesting drug classes and diagnoses that hospices may wish to focus on more closely, as they act to limit polypharmacy and reduce prescription costs.
Governing Fire Protection: The Origins of Municipal Fire Brigades, c.1800–38

Field: Social Sciences (Social Sciences)

During the first four decades of the nineteenth century, municipal governments began to manage the transition into an urban industrial society. They did so by organizing and administering a variety of services, ranging from street cleaning and scavenging to lighting and watching, which were increasingly recognized as public because their effective delivery affected everyone and they were seen as integral to the improvement of the urban environment. Improvement necessitated establishing order and guaranteeing prosperity within rapidly growing towns that lacked the basic infrastructural amenities or administrative structures necessary to be deemed well-governed. From adequate street lighting to regularly swept and paved streets to public fire-engines and paid firemen, nascent municipal governments, the majority of which were concentrated in the North-west of England and in the Scottish Central Lowlands, attempted to keep pace with the intensity of urbanization by strengthening their administrative structures and powers.1
All Business Students Need to know the Same Things!

Field: Business, Management and Accounting (Social Sciences)

This article challenges the conventional approach to cross-cultural communication teaching that instructs students to adapt their communication styles to different cultures by providing them with details about the particular practices of these cultures. It argues for an approach that focuses on common principles of effective communication by pointing out some limitations of the current culture-specific approach and presenting a pilot study that indicates the commonality of communication needs. It suggests some ways to find a different approach for studying international communication and shows that some current research is, in fact, moving in that direction.
Hispanic Nurses’ Experiences of Bias in the Workplace

Field: Health Professions (Health Sciences)

Purpose: The continuing issue of health inequity for Hispanics highlights the importance of retaining Hispanic nurses in the workplace. This article describes the use of short answers such as “Describe the bias you experienced” and “If a patient refused care, what was the reason given?” to increase understandings about bias through the descriptions of Hispanic nurses. In this study, bias was defined as those implicit negative stereotypes and attitudes that negatively affect judgments about, evaluations of, and actions toward others. Design/Method: For this qualitative component of a descriptive study employing both qualitative and quantitative methods, 111 Hispanic nurses responded to open-ended questions about experiences of bias that were included with a survey tool and demographic questionnaire. Findings: Three themes emerged: being overlooked and undervalued, having to prove competency, and living with “only-ness.” Respect was an overarching concept. Discussion/Conclusions: The written descriptions of bias provided depth and understanding to the quantitative findings. Nurse leaders are well positioned to develop and implement strategies to more effectively support Hispanic nurses and to promote nonbiased interactions in the workplace. Implications: Retaining Hispanic nurses is a vital component to address issues of health inequity for Hispanic patients.
Characterization of two cDNA clones for pyruvate dehydrogenase E1 beta subunit and its regulation in tricarboxylic acid cycle-deficient fibroblast.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Two distinct types of cDNA clones encoding for the pyruvate dehydrogenase (PDH) E1 beta subunit were isolated from a human liver lambda gt11 cDNA library and characterized. These cDNA clones have identical nucleotide sequences for PDH E1 beta protein coding region but differ in their lengths and in the sequences of their 3'-untranslated regions. The smaller cDNA had an unusual polyadenylation signal within its protein coding region. The cDNA-deduced protein of PDH E1 beta subunit revealed a precursor protein of 359 amino acid residues (Mr 39,223) and a mature protein of 329 residues (Mr 35,894), respectively. Both cDNAs shared high amino acid sequence similarity with that isolated from human foreskin (Koike, K.K., Ohta, S., Urata, Y., Kagawa, Y., and Koike, M. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 41-45) except for three regions of frameshift mutation. These changes led to dramatic alterations in the local net charges and predicted protein conformation. One of the different sequences in the protein coding region of liver cDNA (nucleotide position 452-752) reported here was confirmed by sequencing the region after amplification of cDNA prepared from human skin fibroblasts by the polymerase chain reaction. Southern blot analysis verified simple patterns of hybridization with E1 beta cDNA, indicating that the PDH E1 beta subunit gene is not a member of a multigene family. The mechanisms of differential expression of the PDH E1 alpha and E1 beta subunits were also studied in established fibroblast cell lines obtained from patients with Leigh's syndrome and other forms of congenital lactic acidosis. In Northern blot analyses for PDH E1 alpha and E1 beta subunits, no apparent differences were observed between two Leigh's syndrome and the control fibroblasts studied: one species of PDH E1 alpha mRNA and three species of E1 beta mRNA were observed in all the cell lines examined. However, in one tricarboxylic acid cycle deficient fibroblast cell line, which has one-tenth of the normal enzyme activity, the levels of immunoreactive PDH E1 alpha and E1 beta subunits were markedly decreased as assessed by immunoblot analyses. These data indicated a regulatory mutation caused by either inefficient translation of E1 alpha and E1 beta mRNAs into protein or rapid degradation of both subunits upon translation. In contrast, the PDH E1 alpha and E1 beta subunits in two fibroblast cell lines from Leigh's syndrome patients appeared to be normal as judged by 1) enzyme activity, 2) mRNA Northern blot, 3) genomic DNA Southern blot, and 4) immunoblot analyses indicating that the lactic acidosis seen in these patients did not result from a single defect in either of these E1 alpha and E1 beta subunits of the PDH complex.
Linked collectors and determiners for: An enigmatic new genus and species of Anthophagini from Georgia (Coleoptera: Staphylinidae: Omaliinae).

Field: Agricultural and Biological Sciences (Life Sciences)

Natural history specimen data linked to collectors and determiners held within, "An enigmatic new genus and species of Anthophagini from Georgia (Coleoptera: Staphylinidae: Omaliinae)". Claims or attributions were made on Bionomia by volunteer Scribes, https://bionomia.net/dataset/5dd36ea3-7c58-4644-a362-7dcac8e05a15 using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, https://gbif.org/dataset/5dd36ea3-7c58-4644-a362-7dcac8e05a15. Formatted as a Frictionless Data package.