jimnoneill/paper-to-field-training huggingface dataset:
How specific are venous symptoms for diagnosis of chronic venous disease?

Field: Medicine (Health Sciences)

Objective The objective of this study is to evaluate whether and which ‘venous’ symptoms are characteristic for patients affected with chronic venous disease compared to patients with other diseases of the lower limbs (e.g. arthrosis, peripheral arterial disease, spinal disc herniation). Methods A cross-sectional study was performed to compare the frequency of venous symptoms among 76 patients with chronic venous disease and reflux and 74 patients with other diseases of the legs without reflux. The VEINES-Sym of the VEINES-QOL/Sym questionnaire was used to evaluate the frequency of symptoms. Demographic, clinical classification and ultrasound findings were also noted. Results A total of 122 patients were included for analysis (response rate of 87%). Presence of venous symptoms was slightly more often reported in the chronic venous disease group than in the non-chronic venous disease group, but differences were small and statistically non-significant. Severity of chronic venous disease as classified by the CEAP classification was not associated with higher proportions of patients reporting symptoms than in non-chronic venous disease patients, except for swelling ( p = .016) and itching ( p = .007) in C3-C6 patients. The largest difference between the chronic venous disease and non-chronic venous disease group was observed for the time of the day at which symptoms were most intense; patients with chronic venous disease were more likely to experience symptoms at the end of the day ( p < .001). Conclusions The small differences in prevalence of reported ‘venous’ symptoms between chronic venous disease patients and patients with other diseases of the legs suggest that these symptoms may be less specific for patients with chronic venous disease and refluxing veins than is usually assumed.
Limits in the application of harmonic analysis to pulsating stars

Field: Physics and Astronomy (Physical Sciences)

\n Using ultra-precise data from space instrumentation, we found that the underlying functions of stellar light curves from some AF pulsating stars are non-analytic, and consequently their Fourier expansion is not guaranteed. This result demonstrates that periodograms do not provide a mathematically consistent estimator of the frequency content for this type of variable stars. More importantly, this constitutes the first counterexample against the current paradigm, which considers that any physical process is described by a continuous (band-limited) function that is infinitely differentiable.\n
Comparative Transcriptomics Identify Key Hypothalamic Circular RNAs that Participate in Sheep (Ovis aries) Reproduction

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Circular RNA (circRNA), as an emerging class of noncoding RNA, has been found to play key roles in many biological processes. However, its expression profile in the hypothalamus, a powerful organ initiating the reproductive process, has not yet been explored. Therefore, we used RNA sequencing to explore the expression of circRNAs in the hypothalamus of sheep with the FecB ++ genotype. We totally identified 41,863 circRNAs from sheep hypothalamus, in which 333 (162 were upregulated, while 171 were downregulated) were differentially expressed in polytocous sheep in the follicular phase versus monotocous sheep in the follicular phase (PF vs. MF), moreover, 340 circRNAs (163 were upregulated, while 177 were downregulated) were differentially expressed in polytocous sheep in the luteal phase versus monotocous sheep in the luteal sheep (PL vs. ML). We also identified several key circRNAs including oar_circ_0018794, oar_circ_0008291, oar_circ_0015119, oar_circ_0012801, oar_circ_0010234, and oar_circ_0013788 through functional enrichment analysis and oar_circ_0012110 through a competing endogenous RNA network, most of which may participate in reproduction by influencing gonadotropin-releasing hormone (GnRH) activities or affecting key gene expression, indirectly or directly. Our study explored the overall expression profile of circRNAs in sheep hypothalamus, which potentially provides an alternative insight into the mechanism of sheep prolificacy without the effects of FecB mutation.
The Role of Negative Affect and Self-Concept Clarity in Predicting Self-Injurious Urges in Borderline Personality Disorder Using Ecological Momentary Assessment

Field: Psychology (Social Sciences)

Deficits in identity as well as negative affect have been shown to predict self-injurious and suicidal behaviors in individuals with borderline personality disorder (BPD). However, less is known about the interactive effects of these two predictors. We examined the moderating effect of a particular component of identity, self-concept, on the relationship between negative affect and self-injurious urges utilizing ecological momentary assessments. Outpatients diagnosed with either BPD (n = 36) or any anxiety disorder but no BPD (n = 18) completed surveys throughout the day over a 21-day period. Higher levels of momentary negative affect predicted greater subsequent urges to self-injure, but only when self-concept clarity was low (z = -3.60, p < .01). This effect did not differ between diagnostic groups. The results suggest that self-concept clarity has a protective effect against self-injurious urges in light of high negative affect, and that this effect may be transdiagnostic.
Towards Micro-Plate Delivery using a re-sized Lab Automation Drone in High Throughput Systems

Field: Engineering (Physical Sciences)

In this paper, the author presents micro-plate grasping work using a re-sized lab automation drone in high throughput system. Here, a robotic arm is affixed to a rotorcraft. The arm's gripper allows the unmanned aerial vehicle to dexterously manipulate objects such as micro-arrays and test samples often used in high throughput systems (HTS). The result shows that drone could improve existing HTS operations. The 6 degree-of-freedom (DOF) arm and gripper design are deployed to pick and place microplae with different samples. Test-and-evaluation approach and results are also given.
SH0768658.10FU

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
Outbreak of monensin poisoning in cattle due to supplementation error

Field: Veterinary (Health Sciences)

ABSTRACT: Iatrogenic intoxications occur in domestic animals. Mortality was observed in a group of calves, reaching 20 deaths until the day of the technical visit, with or without sudden clinical signs, on a farm in the city of Pires do Rio, State of Goiás, Brazil. Deaths after the visit were not accounted systematically. Clinical signs included muscle weakness, ataxia, recumbency, bilateral jugular distention, and death. Suspected diagnosis of poisoning by ionophore antibiotics was made based on clinical and laboratory findings from nine animals, which included high plasma CK and LDH levels, as well as on anatomopathological findings of a recently dead calf, which showed myocardial and skeletal muscle degeneration and necrosis. Monensin overdose (25.5 µg/kg in skeletal muscle and 209.4 µg/kg in the liver) was detected by liquid-chromatography and mass-spectrophotometry analysis, contributing to the confirmation of ionophore poisoning diagnosis.
Safety and Efficacy of Bearxat®XL Tablet (alfuzosin 10 mg) in Patients with Benign Prostatic Hyperplasia: A Prospective Multicenter Study of Primary Care Clinics

Field: Medicine (Health Sciences)

Purpose: A prospective multi-center study was conducted to evaluate the safety and efficacy of alfuzosin (10 mg), for male lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) in primary care clinics. Materials and Methods: Three hundred twenty-four patients with complaints of LUTS associated with BPH were enrolled from 17 clinics. Patients received a 12-week course of 10 mg alfuzosin (Bearxat ⓡ XL Tablet) once daily, and underwent follow-up at 2∼4 and 12 weeks post-treatment. The maximum flow rate (Qmax) and residual urine volume (RUV) were measured at each visit. The International Prostate Symptom Score (IPSS), Quality of Life (QoL), and International Index of Erectile Function (IIEF-5) were evaluated at baseline and post-treatment. During the study period, the presence of orthostatic hypotension was evaluated by blood pressure measurement before and after a postural change. Any adverse effects of alfuzosin including retrograde ejaculation were assessed. Results: Of the 324 enrolled patients, 62 (19.1%) patients dropped out and a total of 262 patients were evaluated. Each value of Qmax, RUV, IPSS, QoL, and IIEF-5 was significantly improved from 14.19±8.85 ml/sec, 41.10±81.44 ml, 18.04±P7.36, 3.81±x0.86, and 11.75±?6.91, respectively, at baseline, to 15.68±6.25 ml/sec, 24.29±29.46 ml, 12.19±M5.59, 2.54±u0.91, and 12.33±?7.55, respectively, at end-point. Retrograde ejaculation was found in 2 patients (2/255, 0.78%) at 2∼4 weeks and 1 patient (1/152, 0.66%) at 12 weeks. The frequency of orthostatic hypotension was 13.27% (30/226) at baseline, 13.11% (27/206, p=0.8658) at 2∼4 weeks, and 14.29% (19/133, p=0.8348) at end-point. The number of patients with adverse events was 36 where the number of adverse events was 60. Among those 60 adverse events, 8 events were related to treatment, which consisted of headache (2), dizziness (2), palpitation (1), voiding difficulty (1), erectile dysfunction (1), and arthralgia (1). Conclusions: Treatment with alfuzosin (10 mg) once daily led to significant improvements in LUTS associated with BPH and QoL in primary care clinic patients. alfuzosin (10 mg) use resulted in few hypotensive events, no deleterious effect on sexual function, and no drug related SAEs during the study. The study findings suggest that alfuzosin (10 mg) can be safely prescribed in primary care clinics for male LUTS with efficacy.
Sensitivity Analysis of Beam Cross-Section Stiffness Using Adjoint Method

Field: Engineering (Physical Sciences)

The design optimization of rotorcraft through multidisciplinary aeroelastic models with hundreds of thousands of degrees of freedom requires a computationally efficient sensitivity analysis to obtain the objective function gradient. A fundamental part of rotorcraft analysis is the flexible multibody dynamics solver, which in the current work relies on an accurate three-dimensional representation of the beams. This paper presents the theoretical adjoint sensitivity analysis of the first structural analysis step, namely the computation of cross-sectional properties of the beams in the form of six-dimensional stiffness matrices. The adjoint equations are carefully derived, as are the derivatives of the objective function with respect to the design parameters. The method is then validated by comparing certain design sensitivities of a three-ply, composite cross-section with those obtained through real-step and complex-step numerical differentiation. The presented analysis allows the user to quantify the effect of basic structural parameters on fundamental sectional properties that can later be used in the full dynamic simulation.
Inferior alveolar nerve injury caused by thermoplastic gutta-percha overextension.

Field: Dentistry (Health Sciences)

Injuries to the inferior alveolar nerve following trauma resulting in a mandibular fracture are well documented and are a well-known risk when surgical procedures are planned for the mandible in the region of the inferior alveolar canal. Such injuries are relatively rare following endodontic therapy. This article reports a case of combined thermal and pressure injury to the inferior alveolar nerve, reviews the pathogenesis of such an injury and makes suggestions for its management.
Re-entrant spin glass and magnetoresistance in Co0.2Zn0.8Fe1.6Ti0.4O4 spinel oxide

Field: Physics and Astronomy (Physical Sciences)

We have investigated the static and dynamical response of magnetic clusters in Co0.2Zn0.8Fe1.6Ti0.4O4 spinel oxide, where a sequence of magnetic states, i.e., paramagnetic to ferromagnetic state at TC⩽270 K and ferromagnetic to canted spin glass (CSG) state at Tf⩽125 K are observed. The time dependence of remanent magnetization shows nonequilibrium spin dynamics in the CSG state, whereas a weak time dependent relaxation is observed in the ferromagnetic state. There is no relaxation effect in the paramagnetic state. The field dependence of the magnetization confirms the absence of long range ferromagnetic order in the system. We considered the magnetic clusters as ferromagnetic domains, in which the spins are not necessarily infinite ordered due to spin canting effects. The variation of the ferromagnetic and antiferromagnetic components and magnetic disorder inside the clusters shows some interesting magnetic and electrical properties in the system, viz. field induced transition in M vs H data, re-entrant magnetic transition in ac susceptibility vs T data, and re-entrant semiconducting behavior in resistivity vs T data.
Gray Scale Ultrasound in Pediatric Urology

Field: Medicine (Health Sciences)

No AccessJournal of Urology1 Apr 1977Gray Scale Ultrasound in Pediatric Urology W.F. Sample, M.T. Gyepes, and R.M. Ehrlich W.F. SampleW.F. Sample More articles by this author , M.T. GyepesM.T. Gyepes More articles by this author , and R.M. EhrlichR.M. Ehrlich More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)58519-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Despite the limitations of initial instrumentation 2-dimensional imaging with ultrasound has become an important diagnostic modality in pediatric urology. A significant experience in evaluating urological abnormalities in children with newer ultrasound equipment is reviewed. Important aspects of instrumentation, technique, anatomy and differential diagnosis are discussed. © 1977 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byBockrath J, Schaeffer A, Kies M and Neiman H (2018) Ultrasound Identification of Impalpable Testicle TumorJournal of Urology, VOL. 130, NO. 2, (355-356), Online publication date: 1-Aug-1983. Volume 117Issue 4April 1977Page: 518-526 Advertisement Copyright & Permissions© 1977 by The American Urological Association Education and Research, Inc.MetricsAuthor Information W.F. Sample More articles by this author M.T. Gyepes More articles by this author R.M. Ehrlich More articles by this author Expand All Advertisement PDF downloadLoading ...
Evaluation of worker safety and health training

Field: Health Professions (Health Sciences)

Background Few studies of worker training have addressed the impact on participant's health and safety behaviors and efforts to change health and safety conditions at the workplace. The present study is an evaluation of these impacts as reported by workers and managers. Methods The UAB/CLEAR program has trained over 1,000 participants since 1992. A survey was mailed to a sample of workers and all participating managers. Results The results revealed that both groups reported increasing personal safety and health behavior, both contributed to emergency preparedness, and both influenced the elimination of hazardous chemicals. Managers reported greater influence on health and safety which may be explained by their relatively more powerful position. However, an impressive percentage of workers reported influencing changes. Conclusions This pattern indicates that when the environment supports joint decision making by workers and management, initiating changes becomes easier. Am. J. Ind. Med. 38:155–163, 2000. © 2000 Wiley-Liss, Inc.
Dentale keramer - typer og egenskaper

Field: Dentistry (Health Sciences)

English summary Dental ceramics - Classification and properties 332-7 The development within dental ceramics has been formidable in recent years. We have a whole range of materials available. Some of these are highly advanced materials and requires knowledge and competence in order to use them correctly. This paper describes the different dental ceramics available today including a classification, mechanical properties and a description of processing techniques with emphasis on the new zirconia materials.
Down regulation effect of McAb HIM 82 on Ca 2+ , protein kinasec, protein tyrosine kinase signal pathway of neutrophils

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Objectives To study the control effects of HIM 82 and HIM 70 on reactive oxygen species (ROS) released from respiratory burst of neutrophils (Np), and the action of HIM 82 on relevant signal transduction pathway Methods The experimental group (combining with McAb) was compared with the control group with regard to the ROS level, activity of G protein, intracellular [Ca 2+ ] level, the activities of PKC and PTK in activated Np to interpret the mechanism by which the McAb down regulated the respiratory burst Results The positive rate of Np combined with HIM 82 was shown over 95% using indirect immunofluorescence assay (control group was 0) The generation of superoxide anion and hydrogen peroxide from PMA treated Np were decreased by 55%( P 0 01) and 32%( P 0 01)with 30 μg/ml HIM 82 The amount of H 2O 2 produced in FMLP or SP stimulated Np were decreased by 16%( P 0 01) and 37%( P 0 01) respectively A similar effect of HIM 70 on Np was observed Further more, the inhibition of H 2O 2 in FMLP activated Np affected by PT, a specific inhibitor for G protein, and in HIM 82 was 42% and 60% separately, and that with both PT and HIM 82 was 85% It was suggested that HIM 82 could enhance the inhibition effect of PT on G protein The intracellular [Ca 2+ ] level of Np stimulated with FMLP was decreased by 85%, and that of Np activated with PMA by 100% nearly in the present of HIM 82 The activities of PKC and PTK in PMA stimulated Np were decreased by 23%( P 0 05) and 35%( P 0 05) separately when treated with HIM 82 Conclusion The McAb HIM 82 could down regulate the ROS produced from activated Np. The mechanism of decreasing ROS may be involved in down regulating Ca 2+ PKC and PTK signal transduction pathway activities that are upstream control systems for NADPH oxidase activation
Outcomes of treatment with daclatasvir and asunaprevir for recurrent hepatitis C after liver transplantation

Field: Medicine (Health Sciences)

Aim The development of direct‐acting oral agents has dramatically changed the treatment strategy of hepatitis C virus (HCV) infection. Here we aimed to reveal the efficacy and safety of daclatasvir (DCV) and asunaprevir (ASV) for recurrent HCV genotype 1 infection after liver transplantation (LT). Methods A retrospective study was undertaken on nine patients who underwent a 24‐week DCV/ASV treatment regimen for recurrent HCV genotype 1 infection. Five of the patients were men; four had failed treatment with pegylated interferon (Peg‐IFN)/ribavirin, two had failed simeprevir/Peg‐IFN/ribavirin, one had the resistance‐associated variant Y93H in the NS5A region, and one underwent maintenance dialysis. Results Median time to treatment initiation following LT was 70 months. Of the nine patients treated with DCV/ASV, eight (88.9%) achieved a sustained viral response 12 weeks after completion of therapy (SVR12). The patient with virologic failure had failed simeprevir/Peg‐interferon/ribavirin therapy 4 months before undergoing the DCV/ASV treatment regimen. In addition, a resistance‐associated variant D168E in the NS3 region was detected in the patient after discontinuation of the DCV/ASV regimen. The trough level of tacrolimus tended to decrease, and renal function showed no significant changes during treatment. Adverse events occurred in two patients (22.2%), but no severe adverse events occurred during treatment. Conclusions The DCV/ASV regimen was well tolerated, resulting in high rates of sustained viral response 12 weeks after completion of therapy for LT patients with recurrent HCV genotype 1 infection.
ChemInform Abstract: MNDO Barrier Heights for Catalyzed Bicycle‐Pedal, Hula‐Twist, and Ordinary cis‐trans Isomerizations of Protonated Retinal Schiff Base.

Field: Chemistry (Physical Sciences)

Abstract Energy barriers to dark cis‐trans isomerization in a protonated retinal Schiff base model (I) in the presence and absence of electrostatic and nucleophilic catalysts are calculated.
Management of cervical dystonia with botulinum neurotoxins and EMG/ultrasound guidance

Field: Medicine (Health Sciences)

A structured clinical approach, based on functional neck anatomy, guides CD assessment and BoNT treatment. Muscles are selected according to clinical, EMG and US findings. US provides anatomical visualization, while EMG complements by detecting muscle activity. We review here the current practice for assisted treatment of CD through BoNT cycles. We also describe how to recognize and manage the main adverse events.
Critical Flow Method: A New Reliability Allocation Approach for a Thermonuclear System

Field: Engineering (Physical Sciences)

In the present work, starting from well-known methodologies, a new reliability allocation method [critical flow method (CFM)] has been proposed. We focused on the most important conventional methods and discussed their limitations in order to motivate the current research. The results show the main common problem of the most conventional reliability allocation methods: they are developed for complex systems with series configurations but not for series–parallel ones. The consequence is an increase of the required units' reliability (series configuration) in order to guarantee the reliability system target. Actually, the design and manufacturing of a subsystem with an extremely low failure rate would consume a considerable amount of economic resources. The proposed method can solve the shortcomings of the conventional methods with a new reliability approach useful to series–parallel configurations in order to obtain an important cost saving. The CFM has been applied to a liquid nitrogen cooling installation in a thermonuclear system, with many series–parallel configurations in order to guarantee the whole safety system. The proposed technique can be applied to working complex systems, and, in general, in the design phase of new installations. By comparing the CFM application results with real parameters, the new technique has been validated. The computational results clearly demonstrate the advantages of the proposed method. In particular, by applying the method to series–parallel configurations, it allocates failure rates higher than conventional methods, with a component cost reduction. Copyright © 2015 John Wiley & Sons, Ltd.