jimnoneill/paper-to-field-training huggingface dataset:
IMMU-16. TWO DISTINCT SUBSETS OF NATURAL KILLER CELLS ARE ENRICHED IN THE TUMOR MICROENVIRONMENT AND CORRELATE WITH SURVIVAL OUTCOME IN HUMAN GLIOBLASTOMA.

Field: Medicine (Health Sciences)

Abstract Glioblastomas (GBM) account for up to 60% of all adult primary brain tumors. With few advances in therapeutics, median overall survival (mOS) remains at 15-months post diagnosis. Success of immunotherapy in peripheral solid tumors may offer an alternative therapeutic approach for patients with GBM tumors; however, no predictive immune features currently inform therapeutic stratification for GBM. Recently, we have identified radiographic tumor contact with the lateral ventricle (LV) as a prognostic indicator of OS, as patients with LV+ GBM survive 7 months less than patients with LV- gliomas. This disparity was independent of known prognostic factors (e.g. KPS, extent of resection). Further, we have identified a correlation between greater immune infiltration and the frequency of tumor subtypes with more favorable prognosis. We therefore hypothesized that differences in overall survival between patients with LV+ and LV- are due, in part, to a uniquely immunosuppressive microenvironment within the LV. Using 35-parameter single-cell mass cytometry (CyTOF) we profiled the immune infiltrate of human GBM tissue acquired in accordance with the Declaration of Helsinki and with the approval of the institutional review board (IRB #131870). Computational approaches (tSNE, Citrus, RAPID) correlated natural killer (NK) cell populations correlating with prognosis. NK cells made of 1–14% of the total immune infiltrate in GBM. Ninety percent of NK cells infiltrating LV- tumors were CD16+CD56dim cytotoxic NK cells (cNK). LV+ gliomas, however, were enriched in CD16+CD56bright immunoregulatory NK cells (irNK). The presence of cNK cells correlated with a 2.5-fold improvement of OS, whereas irNK cells correlated with a 2.2-fold reduction in OS. Further, 30–60% of NK cells infiltrating LV+ tumors expressed checkpoint receptors (TIGIT, TIM3, B7-H3) compared to only 10–20% in LV- tumors. These results suggest that NK cells contribute to immunosuppression in the LV and may serve as alternative targets to T cell-based therapies for GBM.
Control of pore size of porous silica by means of pyrolysis of an organic–inorganic polymer hybrid

Field: Chemistry (Physical Sciences)

Y. Chujo, H. Matsuki, S. Kure, T. Saegusa and T. Yazawa, J. Chem. Soc., Chem. Commun., 1994, 635 DOI: 10.1039/C39940000635
Fluvoxamine effectiveness in patients with various atrial fibrillations forms

Field: Medicine (Health Sciences)

Aim. To assess the effectiveness of depressive disorder (DD) treatment with fluvoxamine in patients with various forms of atrial fibrillation (AF), as well as to investigate fluvoxamine effects on AF clinical course. Material and methods. Group I included 51 patients with various forms of AF and DD, receiving fluvoxamine (50 mg once a day) for 6 months. Group II included 49 patients with AF and non-treated DD (comparison group). All participants received standard antiarrythmic therapy. At 6 months, the incidence of AF attacks and transition from tachycardic to normocardic AF, blood levels of fibrinogen, and depression severity (CES-D questionnaire) were assessed. Results. Three AF patients were withdrawn from fluvoxamine therapy at Week 1, due to adverse effects. In the other Group I patients (n=48), fluvoxamine reduced DD severity by 2,8 points on average (p<0,01). Fluvoxamine treatment was also associated with reduced AF attack incidence in 48,3±9,3 % of the patients with paroxysmal and persistent AF (p<0,01), and transition from tachycardic to normocardic AF in 47,4±11,5 % of the patients with permanent AF (p<0,05). The beneficial clinical effect (reduced DD severity, decreased AF attack incidence, reduced fibrinogen levels) was maximal in patients with paroxysmal and persistent AF, and minimal in patients with permanent AF, possibly due to more advanced heart failure and more severe clinical course of the disease. Conclusion. An antidepressant fluvoxamine reduces DD severity in AF patients and improves the clinical course of various AF forms.
Effects of Hydrogen Implantation on the Structural and Electrical Properties of Nickel Silicide

Field: Materials Science (Physical Sciences)

The effects of hydrogen implantation on the structural and electrical properties of nickel silicide have been investigated. Ni films (30 nm) are electron-beam-evaporated on Si substrates, after which plasma immersion ion implantation is used to introduce hydrogen ions into the Ni films at an energy of 350 eV to a dose of For nickel silicidation reactions, rapid thermal annealing is carried out in the range of 400-750°C for 30 s in a nitrogen atmosphere. It is shown that the implanted samples produce lower sheet resistances than the unimplanted samples across the whole annealing temperature range. X-ray diffraction results show that, regardless of the hydrogen implantation, NiSi is transformed into at temperatures in excess of 700°C. X-ray photoemission spectroscopy results show that the hydrogen implantation plays a role in reducing the nickel oxide layer. Compared to the unimplanted samples, the implanted samples exhibit better surfaces and uniform NiSi/Si interface morphologies. Transmission electron microscopy results show that the grain sizes of the implanted sample are smaller than those of the unimplanted sample. It is further shown that the implanted samples are thermally more stable than the unimplanted samples, which is attributed to the difference in the grain sizes of the nickel silicide films. © 2002 The Electrochemical Society. All rights reserved.
Contemporary British Children's Fiction and Cosmopolitanism

Field: Arts and Humanities (Social Sciences)

This book visits contemporary British children's and young adult (YA) fiction alongside cosmopolitanism, exploring the notion of the nation within the context of globalization, transnationalism and citizenship. By resisting globalization's dehumanizing conflation, cosmopolitanism offers an ethical, humanitarian, and political outlook of convivial planetary community. In its pedagogical responsibility towards readers who will become future citizens, contemporary children's and YA fiction seeks to interrogate and dismantle modes of difference and instead provide aspirational models of empathetic world citizenship. McCulloch discusses texts such as J.K. Rowling's Harry Potter series, Jackie Kay's Strawgirl, Theresa Breslin's Divided City, Gillian Cross's Where I Belong, Kerry Drewery's A Brighter Fear, Saci Lloyd's Momentum, and Julie Bertagna's Exodus trilogy. This book addresses ways in which children's and YA fiction imagines not only the nation but the world beyond, seeking to disrupt binary divisions through a cosmopolitical outlook. The writers discussed envision British society's position and role within a global arena of wide-ranging topical issues, including global conflicts, gender, racial politics, ecology, and climate change. Contemporary children's fiction has matured by depicting characters who face uncertainty just as the world itself experiences an uncertain future of global risks, such as environmental threats and terrorism. The volume will be of significant interest to the fields of children's literature, YA fiction, contemporary fiction, cosmopolitanism, ecofeminism, gender theory, and British and Scottish literature.
Regulation of DTH and IgE responses by IL-4 and IFN-gamma in immunized mice given pertussis toxin.

Field: Immunology and Microbiology (Life Sciences)

Interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) are cytokines with important functions in regulating immune responses. IFN-gamma may be produced by cells responsible for delayed-type hypersensitivity (DTH), whereas IL-4 is essential for IgE production. Pertussis toxin (PT) from Bordetella pertussis enhances both DTH and IgE responses, and causes enhancement of both IFN-gamma and IL-4 secretion in immunized mice. In the present study, the effects of neutralizing monoclonal antibodies against IFN-gamma or IL-4 on DTH, serum IgE and cytokine production were assessed. Treatment with a monoclonal anti-IL-4 antibody at the time of immunization caused a striking increase in DTH responses, and elicited enhanced IFN-gamma expression, while inhibition of the production of IL-4 and IgE was observed. By contrast, injection of a monoclonal anti-IFN-gamma antibody was followed by significant but not complete suppression of DTH reactions. IFN-gamma secretion was also inhibited, whereas IL-4 production and serum IgE were increased. Thus antibodies to IL-4 and IFN-gamma, given at the time of immunization, can profoundly influence the nature of short-term immune responses elicited by PT in immunized mice.
Angioid Streaks

Field: Medicine (Health Sciences)

Angioid streaks, which appear as jagged lines extending from the optic disc, were first described in 1889 by Doyne and then given their current name by Knapp in 1892 due to their vascular appearance (Clarkson and Altman 1982). They were proposed to occur at the level of Bruch's membrane in 1916 with histopathologic verification several decades later (Clarkson and Altman 1982). Angioid streaks can occur in isolation but they are also associated with a range of disease processes including most common pseudoxanthoma elasticum (PXE). Advances in retinal imaging have enabled a more detailed view of these defects and facilitated the management of choroidal neovascularization, which is the most commonly encountered complication.
Proffitt v. Florida

Field: Arts and Humanities (Social Sciences)

This chapter examines Xavier Cortada's depiction of Proffitt v. Florida, the 1976 decision that approved Florida's guided discretion statute after Furman v. Georgia had invalidated the death penalty in 1972. Cortada's depiction is a fantastical piece, capturing the horror of death by electrocution set against two columns of ominous looking Roman numerals. The Roman numerals represent the mechanical imposition of death—the formulaic approach to death penalty decision-making that tells sentencers to add the columns of aggravating and mitigating circumstances and see where the balance lies. Cortada resists this approach as obscuring the human element in death penalty decision-making, the awesome responsibility of sitting in judgment over another human being's life. This chapter explores Cortada's key insight, how we numb ourselves with numbers, then turns to the visual inspiration for Cortada's piece—a painting of a screaming pope by Francis Bacon. Bacon's pope was not a comment on the death penalty, but the themes he was exploring—pain, imprisonment, isolation, and obfuscation—are eerily apropos of the death penalty as well. Both works of art are a comment about distortion and both have something important to say about how the law and institutional design work to distort death.
Efficient cavity control with SNAP gates

Field: Computer Science (Physical Sciences)

Microwave cavities coupled to superconducting qubits have been demonstrated to be a promising platform for quantum information processing. A major challenge in this setup is to realize universal control over the cavity. A promising approach are selective number-dependent arbitrary phase (SNAP) gates combined with cavity displacements. It has been proven that this is a universal gate set, but a central question remained open so far: how can a given target operation be realized efficiently with a sequence of these operations. In this work, we present a practical scheme to address this problem. It involves a hierarchical strategy to insert new gates into a sequence, followed by a co-optimization of the control parameters, which generates short high-fidelity sequences. For a broad range of experimentally relevant applications, we find that they can be implemented with 3 to 4 SNAP gates, compared to up to 50 with previously known techniques.
Digitalizing of power system

Field: Energy (Physical Sciences)

This report is about the author’s final year report on the topic of digitalizing the power system. Specifically, the aim is to digitalize the microgrid system to increase automation, improve efficiency, reducing operation and maintenance, and system optimization. This report presents the literature review on various topic. Literature review include key technology for data gathering, data storage, data sharing, control infrastructure, Internet-of-things technology, and example of small scale microgrid. Author also review the communication infrastructure as it is fundamentally important to optimize communication between terminal and data centers. Notable technology is smart sensors as it is becoming more intelligent and also able to handle more functions. The author will also review the concept of smart grid and microgrid to get a basis understanding of the different type of power system. Lastly the author explore a simple design for a micro grid system.
Rhema University, Obeama-Asa – Rivers State Utme Form,20 22/20 23 Transfer Form,Jupeb\\Predegree Form Call ☎ 09078816209 DR MRS GRACE ☎ Post Utme Form.. Call Admin Guideline On (09078816209 or 09078816209)...

Field: Arts and Humanities (Social Sciences)

Rhema University, Obeama-Asa &ndash; Rivers State Utme Form,20 22/20 23 Transfer Form,Jupeb\\Predegree Form Call ☎️ 09078816209 DR MRS GRACE ☎️ Post Utme Form.. Call Admin Guideline On (09078816209 or 09078816209)...
Coronary angiographic abnormalities in patients of diabetes mellitus and metabolic syndrome

Field: Medicine (Health Sciences)

Background: Diabetes mellitus and Metabolic syndrome, both are established risk factors for CAD. In our study, we tried to compare the effects of these two diseases individually as well as their combined effect.Methods: we performed an Observational, cross-sectional, hospital-based, single center study on 240 patients presenting at our hospital with chest pain. we assessed the severity of CAD with Syntax score and divided the study population into three groups with SS of <=22, 23-32 and >=33.Results: statistically significant difference was found in each of the first three groups of combined MS plus DM, only MS without DM, only DM without MS when compared with the fourth group of nondiabetics nonmetabolic syndrome patients. Strongest difference was found between patients with combined diabetes and metabolic syndrome with those who had none of these (<0.001). Thus, complexity of CAD is much severe in patients who have diabetes and/or metabolic syndrome.Conclusions: Patients having diabetes mellitus and/or metabolic syndrome are found to have more severe form of coronary artery disease than those who don’t have either of these. However, presence of both diabetes and metabolic syndrome has not been found to impose any significant additional risk than their isolated presence.
Return on Investment of Harm Reduction Program in Malaysia

Field: Health Professions (Health Sciences)

Malaysia has recorded a cumulative total of over 98,000 persons infected with HIV by the end of 2012. The number of recorded cases of HIV infection in Malaysia is highest among people who inject drugs(PWID) which constitutes 67 per cent of the total cumulative cases. In the effort to mitigate the HIV transmission among PWID, the government of Malaysia initiated harm reduction programmecomprising the Needle Syringe Programme (NSP) and Methadone Maintenance Therapy (MMT) in 2006. Since its inception as a National Pilot Project in 2006, the funding for the programmes hasgradually been increased to increase the coverage of these programmes. During the phase of the harmreduction programme, the NSP was carried out by non-governmental organizations affiliated with theMalaysian AIDS Council whilst the MMT was provided by medical practitioners in the public andprivate health sectors. Since then the MMT programme has been expanded into the non-health sectorand is being implemented by the prisons and the National Anti-Drug Agencies (NADA). By the end of2011, the Malaysian government has invested a total of RM69.3 million for harm reduction programme.Despite the official recognition that the harm reduction programme may have been successful inreducing HIV transmission, concerns have been raised that public funding for these activities may not be sustainable in the long run and sources of alternative funding is desired. Thus, an assessment of the economic impact and cost-effectiveness of this programme is very much needed. This project aimed to assess whether the harm reduction programme in Malaysia, which consists of NSP and MMT programmes amongst PWID, have been cost-effective from the perspective of the government by estimating savings in direct health care cost to the government resulting from infections that were averted because of the NSP and MMT programmes. The cost-effectiveness and ROI of these programmes were evaluated over 3-time periods, from 2006 to current year 2013, a short 10-year future projection from 2013 to 2023, as well as projections from 2006 to 2050 to capture the long-term costs and benefits of the programmes. The main objectives of this study are to evaluate whether the harm reduction programme in Malaysia is cost-effective and whether they provide return on investments to the government. The cost-effective evaluation is aimed at examining whether the harm reduction programme represent value for money from the viewpoint of society, i.e. the benefits obtained justify the money spent by the government. On the other hand, the ROI analysis examines whether these programmes provide cost savings to the government, who is the main programme funder. As such, this economic evaluation has been conducted from the government perspective only. Cost of provision of MMT from private practitioners have not been included in the analysis.
Diagnosis and therapy of neuroblastoma and other neural crest tumors using Iodine-131-meta-iodobenzylguanidine

Field: Medicine (Health Sciences)

Like pheochromocytoma, neuroblastoma is capable of synthesis and storage of catecholamines. Therefore the authors evaluated the yield of I-131-MIBG total body scintigraphy in the detection of this tumor and applied I-131-MIBG therapeutically. Total body scintigraphy was performed 24, 48 and 96 hrs after administration of 18.5 or 37 MBq I-131-MIBG. 23 patients with neuroblastoma were examined (47 studies). I-131-MIBG-scintigraphy confirmed complete remission in 7 patients and correctly detected residual/recurrent abdominal tumormasses in 5 patients and metastases in 14 patients. In 1 adult patient the scintigram was false negative. 3 children with metastatic neuroblastoma received multiple therapy doses of I-131-MIBG (1.5-3.9 GBq). Reduction of tumor size and good palliation was achieved in 2 patients with progressive disease. Intense accumulation of I-131-MIBG was observed in 1 patient with inoperable medullary thyroid carcinoma and in another with metastatic pheochromocytoma. Both received I-131-MIBG-therapy (3.7-7.9 GBq), resulting in a reduction of the tumor mass. It is concluded that I-131-MIBG, is a useful agent for diagnosis, follow up and therapy of neuroblastoma. It may occasionally be of use in therapy of other neural crest tumors and should therefore be considered when other treatment modalities are ineffective.
Hubungan Pola Asuh Orang Tua dengan Akhlak Remaja di Kampung Jaura RT 001/ 001 Desa Pabuaran Kecamatan Sukamakmur Bogor

Field: Social Sciences (Social Sciences)

The background of this research is that there are many things that affect the morals of adolescents, one of which is parenting, because parents are the closest environment, the first and foremost educator in the family, as well as being a good figure for them. With this background, researchers are interested in examining whether there is a relationship between parenting patterns and adolescent morals. This research was conducted in Kampung Jaura RT 001/001 Pabuaran Sukamakmur Village Bogor. The study population was 155 families, while the sample used was only 50 people with stratified random sampling technique. This study applies the correlation method with the research instrument using a questionnaire. Data analysis using Product Moment correlation technique. The results of this study show r count = 0.610 > r table = 0.278. Thus, HO is rejected and Ha is accepted, which means that there is a relationship between Parenting Patterns and Adolescent Morals. Likewise, the significant test with the t test shows t count 5,339 > t table 2,010. This means that the relationship between parenting and adolescent morals is a significant relationship. Keywords: Relationships, Parenting Patterns, Adolescent Morals.
How Should Textbooks Summarize the Status of Parapsychology? A Reply to Roig, Icochea, and Cuzzucoli (1991)

Field: Arts and Humanities (Social Sciences)

In contrast to Roig, lcochea, and Cuzzucoli (1991), we argue that textbook authors should maintain their generally skeptical description of parapsychology. We also argue that textbook authors may mislead readers when they say that future research will resolve the controversy.
Facial Feature Recognition with Multi-task Learning and Attention-based Enhancements

Field: Computer Science (Physical Sciences)

Facial feature recognition (FFR) has witnessed a remarkable surge in recent years, driven by its extensive applications in identity recognition, security, and intelligent imaging. The UTKFace dataset plays a pivotal role in advancing FFR by providing a rich dataset of facial images with accurate age, gender, and race labels. This paper proposes a novel multi-task learning (MTL) model that leverages the powerful Efficient-Net architecture and incorporates attention-based learning with two key innovations. First, we introduce an age-specific loss function that minimizes the impact of errors in less critical cases while focusing the learning process on accurate age estimation within sensitive age ranges. This innovation is trained using the UTKFace dataset and is specifically optimized to improve accuracy in age estimation across different age groups. Second, we present an enhanced attention mechanism that guides the model to prioritize features that contribute to more robust FFR. This mechanism is trained on the diverse and challenging images of UTKFace and is capable of identifying subtle and discriminative features in faces for more accurate gender, race, and age recognition. Furthermore, our proposed method achieves a 30% reduction in model parameters compared to the baseline network while maintaining accuracy. Extensive comparisons with existing state-of-the-art methods demonstrate the efficiency and effectiveness of our proposed approach. Using the UTKFace dataset as the evaluation benchmark, our model achieves a 0.62% improvement in gender recognition accuracy, a 2.35% improvement in race recognition accuracy, and a noteworthy 3.23-year reduction in mean absolute error for age estimation.