jimnoneill/paper-to-field-training huggingface dataset:
Drug interactions between antihypertensive drugs and non‐steroidal anti‐inflammatory agents: a descriptive study using the French Pharmacovigilance database

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Drug–drug interactions ( DDI s) between antihypertensive drugs and non‐steroidal anti‐inflammatory drugs ( NSAID s) can lead to adverse drug reactions ( ADR s). Guidelines are available to help prescribers deal with these drug associations, but their implementation is not well evaluated. The aims of this study were to assess the prevalence of NSAID s exposure in patients treated with antihypertensive drugs, using the French Pharmacovigilance database, and explore the ADR s related to DDI s between antihypertensive drugs and NSAID s. Over the 11, 442 notifications of ADR s recorded in this database in patients treated with oral antihypertensive drugs between 2008 and 2010, 517 (4.5 and 95% CI : 4.1–4.9) also included exposure to NSAID s. These subjects were more frequently women, took more drugs in general, and were younger and less frequently treated with antiplatelet drugs. In 24.2% of them (125 patients), a DDI between NSAID s and antihypertensive drugs was potentially the cause of the reported ADR . Acute renal failure caused by DDI s between NSAID s and angiotensin‐converting enzyme inhibitors ( ACEI s), angiotensin receptor blockers ( ARB s), or diuretics was the most frequently reported ADR (20.7%). Finally, in the French Pharmacovigilance database, around one‐fourth of associations NSAID s + antihypertensive drugs are associated with a ‘serious’ ADR (mainly acute renal failure), suggesting that this well‐known DDI is not enough taken into account by prescribers.
Factors related to natural variation in the gaze-by-expression interaction when processing threat cues

Field: Psychology (Social Sciences)

The face conveys a wide range of cues. Facial expression can signal how an individual is feeling, and gaze can signal where their attention is focused. Integrating information about others’ expressions and gaze influences how we direct our own attention, form impressions of others, and assess threats. This study was designed to explore how people with certain personality traits such as alexithymia and sensory processing sensitivity (SPS), as well as those with mental health problems characterized by anxiety integrate expression and gaze cues when viewing faces signaling two different kinds of “threat” cues: anger and fear. Participants N = 74 (49 female; Mage = 20.45 years, SD = 4.64) with varying degrees of alexithymia and SPS were administered self-report questionnaires on their mood, and levels of anxiety, social anxiety, and anxiety sensitivity. They then completed two tasks requiring speeded judgments in which they decided if an expressive stimulus face was looking at them or not (gaze task) and if the stimulus face was angry or fearful (expression task). A series of ANOVAs and exploratory correlation analyses were used to test the relationship between variables with task performance. Results revealed that: (1) the order in which gaze and expression judgment tasks are completed is an important determinant of task performance; (2) the cone of gaze is more symmetrical when viewing angry (vs. fearful) faces; and (3) anxiety-related problems, SPS, and difficulties with emotional appraisal are negatively associated with problems in fear processing when gaze is strongly averted and viewers are focused on performing mental state attributions and self-directed threat assessment. This research furthers our understanding of individual difference factors that may influence the form of gaze-by-expression interactions that help shape one’s social perception. Additionally, the findings emphasize the importance of investigating the differences between left and right averted gaze.
The structure and properties of phthalocyanine films grown by the molecular beam epitaxy technique. I. Preparation and characterization

Field: Materials Science (Physical Sciences)

Ultrathin films of the cofacially stacked F-bridged Al-phthalocyanine polymer, (AlPcF)n , have been grown using the highly controlled technique of molecular beam epitaxy. A parallel orientation of the polymer backbone to the substrate surface occurs in films on silicon and quartz, but epitaxy is not apparent. On single-crystal alkali halide substrates, the backbone is perpendicular to the substrate surface, and an epitaxial relationship exists that is influenced by the interaction between the substrate and phthalocyanine molecule. The transmission electron microscopy studies indicate that the most highly ordered films are produced on KBr(100) and have good continuity and unidirectional crystallite orientation.
N4: On assessing and anticipating consequences of innovation

Field: Environmental Science (Physical Sciences)

This project is about showing whether RMSs are effective. It will seek to quantify the consequences of improved RMS for community livelihoods, resource productivity, land quality, and downstream water quality and siltation. It will specifically measure the downstream, cross-scale consequences of successful innovation in the Ethiopian highlands. \nThis project will develop methods to anticipate ex ante the likely consequences of introducing improved RMS as well as monitoring and measuring these consequences ex post. Finally, it will introduce methods for adaptive management. \nAssessing and anticipating the consequences of improved RMS will cover a range of variables, among them water allocation, land and water use practices, community infrastructure, water productivity, farm income, livelihoods resilience and ecosystem services.
Effect of PKD1 Gene Missense Mutations on Polycystin-1 Membrane Topogenesis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Polycystin-1 (PC1), the product of the polycystic kidney disease-1 (PKD1) gene, has a number of reported missense mutations whose pathogenicity is indeterminate. Previously, we utilized N-linked glycosylation reporter tags along with membrane insertion and topology assays to define the 11 membrane-spanning domains (I-XI) of PC1. In this report, we utilize glycosylation assays to determine whether two reported human polymorphisms/missense mutations within transmembrane (TM) domains VI and X affect the membrane topology of PC1. M3677T within TM VI had no effect on the topology of this TM domain as shown by the ability of two native N-linked glycosylation sites within the extracellular loop following TM VI to be glycosylated. In contrast, G4031D, within TM X, decreased the glycosylation of TM X reporter constructs, demonstrating that the substitution affected the C-terminal translocating activity of TM X. Furthermore, G4031D reduced the membrane association of TM X and XI together. These results suggest that G4031D affects the membrane insertion and topology of the C-terminal portion of polycystin-1 and represents a bona fide pathogenic mutation.
Analysis of CFRP Confined Concrete Cylinders by using ABAQUS Software

Field: Engineering (Physical Sciences)

The fiber-reinforced polymer (FRP) wrapping is widely used in concrete column strengthening, as it can enhance concrete strength and ductility. This study aims to develop finite element numerical model that can capture the behavior of the short cylinder column confined with CFRP. After validating the proposed finite element models with previous experimental works, a series of parametric studies have been conducted, including, CFRP number of layers, concrete grade, confinement configuration, and size of samples are investigated in terms of stress-strain curves, ductility, and volumetric strain. The results indicate a significant improvement in concrete strength after fully CFRP wrapping. However, the partial confinement records less improvement in concrete strength but considerable ductility. By increasing the specimen’s size and maintaining the same confinement ratio, the strength enhancement was decreased. Based on this observation; it can be concluded that; by increasing the samples sizes, it should be escorted with more confining ratio than that of the small size. Moreover, it was concluded that as the number of layers increases the ductility increases whether it was full or partial confinement configuration. The CFRP confinement can control the specimen’s dilation during the axial compression test thus presenting less volumetric strain. The proposed formula by (Lam & Teng, 2003) that can predict the stress-strain response of FRP full confined concrete cylinder was compared with the corresponding values. The results indicated that; a good matching was noticed only for the samples located in the same area that was studied by (Lam & Teng, 2003).
Fluid Shear Stress Increases the Intra-cellular Storage Pool of Tissue-type Plasminogen Activator in Intact Human Conduit Vessels

Field: Medicine (Health Sciences)

Summary We investigated the effect of shear stress on the expression of tissuetype plasminogen activator (t-PA) in intact human conduit vessels. Human umbilical veins were exposed to high or low shear stress (25 vs < 4 dyn/cm2) at identical intraluminal pressure (20 mmHg) for 1.5, 3, and 6 h in a new computerized biomechanical perfusion system. High shear perfusion induced a marked, time-dependent increase in t-PA immunostaining in both the endothelium and the media. t-PA relative to GAPDH gene expression increased by 54 ± 14% in highcompared to low-sheared vessels (p = 0.002). By contrast, t-PA release into the perfusion medium was similar in vessels perfused under high or low shear stress conditions. The results show that shear stress independently of pressure is a potent fluid mechanical stimulus for upregulation of the intracellular storage pool of t-PA in the vascular wall of fresh human conduit vessels. The shear effect is associated with an increased t-PA gene expression.
Materials Experiment and Analysis Database: Material library with Co,Cu,Mn,Na deposited by INKJET on 2015-01-21 from Plate 00023533 annealed at 400.0C to add O on 2015-01-23

Field: Materials Science (Physical Sciences)

This record is a component of the Materials Experiment and Analysis Database (MEAD). It contains raw data and metadata from millions of materials synthesis and characterization experiments, as well as the analysis and distillation of that data into property and performance metrics. The unprecedented quantity and diversity of experimental data are searchable by experiment and analysis attributes generated by both researchers and data processing software.
Classification of Desirable and Atherosclerotic Risk Level of Serum Triglyceride and High Density Lipoprotein Cholesterol

Field: Medicine (Health Sciences)

Aim To discuss the desirable and risk level of triglyceride (TG) and high density lipoprotein cholesterol (HDLC) in cardiovascular diseases. Methods Serum lipids of 2915 middle aged subjects of Beijing professional population were studied during annual physical surveys in year 2001. The effects of different levels of TG on HDLC and TG/HDLC ratio were analyzed statistically. Results HDLC level was relatively low as compared with that of the American whites, less then 5% in this studied group had HDLC below 0.9 mmol/L. According to our long term prospective study of the elderly, HDLC level above 1.03 mmol/L may be considered as desirable. Gradient increase in TG level was accompanied by progressive decrease in HDLC. While TG at 1.14 mmol/L, HDLC levels of both sexes were at desirable level, but with slight decrease in females when the TG level up to 1.7 mmol/L, marked decrease in both sexes when TG increased to2.27 mmol/L. The acceptable TG/HDLC ratio was about 2 3 (by mg/mg). Conclusion According to this study and our previous experience, we propose that it may be appropriate to adopt the TG and HDLC level classification of ATPШ guidelines of the National Cholesterol Education Program of United States.
Bootstrapped Pivots for Sample and Population Means and Distribution Functions

Field: Mathematics (Physical Sciences)

In this paper we introduce the concept of bootstrapped pivots for the sample and the population means. This is in contrast to the classical method of constructing bootstrapped confidence intervals for the population mean via estimating the cutoff points via drawing a number of bootstrap sub-samples. We show that this new method leads to constructing asymptotic confidence intervals with significantly smaller error in comparison to both of the traditional t-intervals and the classical bootstrapped confidence intervals. The approach taken in this paper relates naturally to super-population modeling, as well as to estimating empirical and theoretical distributions.
DynProfiler: a Python package for comprehensive analysis and interpretation of signaling dynamics leveraged by deep learning techniques

Field: Computer Science (Physical Sciences)

Abstract Summary Signaling dynamics encode important features and regulatory mechanisms of biological systems, and recent studies have reported the use of simulated signaling dynamics with mechanistic modeling as biomarkers for human diseases. Given the success of deep learning techniques, it is expected that they can extract informative patterns from simulation results more effectively than traditional approaches involving manual feature selection, which can be used for subsequent analyses, such as patient stratification and survival prediction. Here, we propose DynProfiler, which utilizes the entire signaling dynamics, including intermediate variables, as input and leverages deep learning techniques to extract informative features without requiring any labels. Furthermore, DynProfiler incorporates a modern explainable AI solution to provide quantitative time-dependent importance scores for each dynamics. Using simulated dynamics of patients with breast cancer as an example, we demonstrate DynProfiler’s ability to extract high-quality features that can predict mortality risk and identify important dynamics, highlighting upregulated phosphorylated GSK3β as a biomarker for poor prognosis. Overall, this tool can be useful for clinical application, as well as for elucidating biological system dynamics. Availability and implementation The DynProfiler Python library is available in GitHub at https://github.com/okadalabipr/DynProfiler.
Control of Lung Metastasis Progression in Mice: Role of Growth Kinetics of 3LL Lewis Lung Carcinoma and Host Immune Reactivity<xref ref-type="fn" rid="fn2">2</xref>, <xref ref-type="fn" rid="fn3">3</xref>

Field: Medicine (Health Sciences)

Studies were made of the growth of metastases of the 3LL Lewis lung carcinoma in tumor-bearing and tumor-excised C57BL/6 mice after intrafootpad inoculation of different cell doses to the intact or immunosuppressed host. The total metastatic volume was higher in tumor-bearing mice given transplants of low doses of 3LL cells (3 X 10(4)- 1 X 10(5)) than in mice receiving high doses of cells (1 X 10(6)-5 X 10(6)). The growth of postoperative lung metastases depends on the size of the removal of local tumors and the rate of their development. Surgical removal of small, medium, or large local tumors, respectively, resulted in the development of smaller, similar, or larger volumes of pulmonary metastases compared to the metastases in tumor-bearing mice not having surgery. Accelerated growth of postoperative metastases in mice inoculated with low doses of 3LL cells was observed following removal of the local tumors of more than 310 mm3. The same effect was observed on mice given transplants of high doses of 3LL cells only when the removed local tumors had reached a volume of more than 550 mm3. In immunologically suppressed tumor-bearing mice, acceleration of the metastatic growth in the lungs was observed independently of the inoculum size. Even in the immunosuppressed mice, the growth of metastases was not optimal, and an additional stimulus for their growth was achieved following the removal of local tumors. This finding suggested that immunologic and nonimmunologic mechanisms were involved in the control of the metastatic growth of 3LL tumors in mice.
Linking Housing Growth to Water Supply: New Planning Frontiers in the American West

Field: Environmental Science (Physical Sciences)

Abstract Abstract Faced with rapid population growth and the increasing difficulty of obtaining new sources of water, many western states now condition the approval of residential development on the adequacy of long-term water supplies. Although planners have generally supported these laws as means of linking water and land use decisions, their implementation is proving challenging. Drawing on the experiences in five western states, we evaluate whether water adequacy laws effectively meet the dual objectives of protecting the resource base and encouraging the development of supplies to support growth.
Mostly sports and congratulations : Twitter, Facebook, and Alberta higher education

Field: Social Sciences (Social Sciences)

One of the defining features of social media is the capability for interaction, specifically for the audience to respond to previously posted content. Higher education research to date has focused on the content published by institutions, with minimal examination of the content sent back to institutions. Previous research has often operated as though higher education’s social media is homogenous, without acknowledging the variation in institutional mission. Furthermore, previous research has tended to treat institutions’ social media accounts as the same, without examination of differences between social media platforms. This research examines both gaps. Twitter posts mentioning primary and secondary accounts of 25 Albertan post-secondary institutions were gathered during a two-month interval alongside messages posted to the same institutions’ primary Facebook pages, to determine which topics led the audience to communicate back to institutions and to examine whether any difference existed between account types and platforms. Analysis of the data, using sentiment analysis and topic modeling, found that audiences tended to discuss institutions’ sports teams, as well as events or features unique to institutions. No difference in sentiment or emotion was found between account types, with most messages being moderately positive. Facebook messages tended to include more descriptive language while the higher volume of tweets suggested that Twitter audiences appear to be more prone to interaction than Facebook audiences. Institutions may be best served by pursuing different social media strategies for Twitter and Facebook.
Fig. 81 in The genus Aphaniosoma Becker, 1903 (Diptera: Chyromyidae) in the Eastern Mediterranean and Middle East, with descriptions of new species

Field: Agricultural and Biological Sciences (Life Sciences)

Fig. 81. Aphaniosoma sp. aff. sodalis Collin, 1949, ♂, paralectotype (NHMUK, B.M. 1935–354, bar code 013435848). A. Habitus, lateral view. B. Hypopygium in situ, lateral view.
Seasonal variations in trophic dynamics of nanoflagellates and picoplankton in coastal waters of the western subtropical Pacific Ocean

Field: Environmental Science (Physical Sciences)

AME Aquatic Microbial Ecology Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsSpecials AME 51:263-274 (2008) - DOI: https://doi.org/10.3354/ame01196 Seasonal variations in trophic dynamics of nanoflagellates and picoplankton in coastal waters of the western subtropical Pacific Ocean An-Yi Tsai1, Kuo-Ping Chiang1,3,4,*, Jeng Chang2,3, Gwo-Ching Gong3 1Institute of Environmental Biology and Fishery Science, 2Institute of Marine Biology, 3Institute of Marine Environmental Chemistry and Ecology, and 4Center for Marine Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 202-24, Taiwan, ROC *Corresponding author. Email: kpchiang@mail.ntou.edu.tw ABSTRACT: This investigation was undertaken between August 2002 and July 2003 at a coastal station on the southern edge of the East China Sea. We found a 2-phase (warm season, >25°C [June to October] and cold season, <25°C [November to May]) seasonal cycle with a 10-fold variation in the growth of bacteria (heterotrophic bacteria only) and picophytoplankton, primarily coccoid cyanobacteria (Synechococcus spp.), and nanoflagellate grazing rates upon them. Growth rate in bacteria and Synechococcus spp. appeared to be affected by changes in temperature, and the nanoflagellate grazing rate was controlled by concentrations of bacteria and Synechococcus spp. The seasonal cycles of abundance in bacteria and Synechococcus spp. were a reflection of their changing net growth rates (i.e. picoplankton growth rates – nanoflagellate grazing rates), which were highest at the beginning of the warm season. During the warm season, nanoflagellates consumed an equal amount of bacteria and Synechococcus spp.; therefore, growth in both groups was affected equally by grazing in the warm season. However, during the cold season, bacteria contributed more to nanoflagellate carbon consumed than did Synechococcus spp. because the growth rate of Synechococcus spp. was low. We conclude that during the warm season a significant part of bacteria and Synechococcus spp. carbon is channeled through the microbial loop, possibly making it an important link between primary production and higher trophic levels. KEY WORDS: Synechococcus spp. · Picoplankton · Nanoflagellate · Microbial loop Full text in pdf format PreviousNextCite this article as: An-Yi T, Chiang KP, Chang J, Gong GC (2008) Seasonal variations in trophic dynamics of nanoflagellates and picoplankton in coastal waters of the western subtropical Pacific Ocean. Aquat Microb Ecol 51:263-274. https://doi.org/10.3354/ame01196 Export citation RSS - Facebook - Tweet - linkedIn Cited by Published in AME Vol. 51, No. 3. Online publication date: June 16, 2008 Print ISSN: 0948-3055; Online ISSN: 1616-1564 Copyright © 2008 Inter-Research.
The Geometric Technique

Field: Mathematics (Physical Sciences)

In this chapter we develop the basic technique for calculating syzygies. It applies to the subvarieties Y in an affine space X with a desingularization Z which is a total space of a vector bundle over some projective variety V, which is a subbundle of the trivial bundle X × V over V. In such situation the Koszul complex of sheaves on X × V resolving the structure sheaf of Z has terms that are pullbacks of vector bundles over V. Taking the direct image of this Koszul complex by the projection p : X × V → V, one gets the formula expressing terms on the free resolution of the coordinate ring of Y in terms of cohomology of bundles on V. One also gets interesting complexes by taking direct images of the Koszul complex twisted by a pullback of a vector bundle on V. In this chapter we discuss the general construction and properties of direct images of Koszul complexes. The examples will be given in following chapters.