jimnoneill/paper-to-field-training huggingface dataset:
SCE as a CASE: an extendible service creation architecture

Field: Computer Science (Physical Sciences)

A service creation process (or environment) can be seen as a specialized type of a computer-aided software engineering process (or environment), which is tightly coupled with the intelligent network. As such, the following characteristics are considered essential: automatic code generation capability; independence from service control platform; integrated environment; and extendability. This paper examines those characteristics in detail and describes the ways to achieve these characteristics. It also discusses some issues relating to the current standardization activities and results.
Reply to Letter to the Editor

Field: Medicine (Health Sciences)

No AccessJournal of Urology1 Feb 2013Reply to Letter to the Editor M.R. SafarinejadMD M.R. SafarinejadM.R. Safarinejad More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.01.085AboutPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookLinked InTwitterEmail Professor of Urology, P.O. Box 19395-1849, Tehran – Iran, Tel: 00982122454499, Fax: 00982122456845© 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information M.R. Safarinejad More articles by this author Expand All Advertisement PDF DownloadLoading ...
[Takayasu's arteritis and rheumatoid arthritis: a rare association - about an observation].

Field: Medicine (Health Sciences)

L'artérite de Takayasu ou maladie de Takayasu (MT) et la polyarthrite rhumatoïde (PR) et sont deux maladies inflammatoires chroniques et leur association a été rapportée dans la littérature à travers quelques observations de cas sporadiques. Nous rapportons une nouvelle observation d'une telle association. Une patiente âgée de 44 ans, diagnostiquée avec une polyarthrite rhumatoïde à facteur rhumatoïde positif, qui a développé des céphalées avec des vertiges de caractère permanent. L'examen révélait un pouls radial et huméral abolis à droite, un souffle carotidien bilatéral et une tension artérielle imprenable à droite. L'artériographie a confirmé la présence d'une atteinte de l'arc aortique type MT. Le diagnostic d'une maladie de Takayasu associée à une polyarthrite rhumatoïde était retenu. La patiente était traitée par une corticothérapie (prednisone à la dose de 0,5 mg/kg par jour) et un traitement de fond par Méthotrexate avec une bonne réponse initiale. A travers notre observation et une revue de la littérature, les caractéristiques épidémiologiques, étiopathogéniques, cliniques, thérapeutiques et évolutives de cette association seront discutées.
Successful transplantation of human benign breast tumors into the athymic nude mouse and demonstration of enhanced DNA synthesis by human placental lactogen.

Field: Medicine (Health Sciences)

Abstract Each of 10 biopsy specimens of benign human breast tumors, obtained from 10 patients, was cut into slices (30 slices/specimen) and transplanted s.c. into 3 female athymic nude mice (30 mice, 10 grafts/mouse). Of the 3 mice in each of the 10 triads, 2 mice were intact and 1 mouse was ovariectomized 30 days before transplantation. Ten days after transplantation the following s.c. injections were administered twice dally for 20 days: 0.9% NaCl solution to one intact and one ovariectomized mouse and 0.5 mg of human placental lactogen in 0.9% NaCl solution to one intact mouse of each triad. On the 20th day of injections each mouse received an i.p. injection of [ 3 H]thymidine and was sacrificed 1 hr later. Grafts were removed and processed for histological and autoradiographical analyses. Evaluation of DNA synthesis was obtained by counting the total number of [ 3 H]thymidine-labeled epithelial cells in 6 sections obtained from each graft. All ten of the biopsy specimens, regardless of host hormonal treatment, were accepted and maintained by these mice. The grafts retained their original morphology. The ductal epithelium of these grafts were shown to synthesize DNA, an activity that was significantly increased by human placental lactogen. Ovariectomy did not significantly influence the mean incorporation of [ 3 H]thymidine into DNA. These results provide evidence that human placental lactogen is a direct stimulant of DNA synthesis of the ductal epithelium found in benign human breast tumors. In addition, the athymic nude mouse appears to be a promising, valuable tool for the in vivo study of factors influencing the development and growth of the human breast.
A minimum ductility design method for non-rectangular high-strength concrete beams

Field: Engineering (Physical Sciences)

The flexural ductility of solid rectangular reinforced concrete beams has been studied quiternextensively. However, many reinforced concrete beams are neither solid nor rectangular; examples includern T-, -, - and box-shaped beams. There have been few studies on the flexural ductility of nonrectangularrnreinforced concrete beams and as a result little is known about the possible effect of sectionalrnshape on flexural ductility. Herein, the effect of sectional shape on the post-peak flexural behaviour ofrnreinforced normal and high-strength concrete beams has been studied using a newly developed analysisrnmethod that employs the actual stress-strain curves of the constitutive materials and takes into account thernstress-path dependence of the stress-strain curve of the steel reinforcement. It was revealed that thernsectional shape could have significant effect on the flexural ductility of a concrete beam and that thernflexural ductility of a T-, -, - or box-shaped beam is generally lower than that of a solid rectangularrnbeam with the same overall dimensions and the same amount of reinforcement provided. Based on thernnumerical results obtained, a simple method of ensuring the provision of a certain minimum level ofrnflexural ductility to non-rectangular concrete beams has been developed.
The p38α/β MAPK functions as a molecular switch to activate the quiescent satellite cell

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Somatic stem cells cycle slowly or remain quiescent until required for tissue repair and maintenance. Upon muscle injury, stem cells that lie between the muscle fiber and basal lamina (satellite cells) are activated, proliferate, and eventually differentiate to repair the damaged muscle. Satellite cells in healthy muscle are quiescent, do not express MyoD family transcription factors or cell cycle regulatory genes and are insulated from the surrounding environment. Here, we report that the p38α/β family of mitogen-activated protein kinases (MAPKs) reversibly regulates the quiescent state of the skeletal muscle satellite cell. Inhibition of p38α/β MAPKs (a) promotes exit from the cell cycle, (b) prevents differentiation, and (c) insulates the cell from most external stimuli allowing the satellite cell to maintain a quiescent state. Activation of satellite cells and p38α/β MAPKs occurs concomitantly, providing further support that these MAPKs function as a molecular switch for satellite cell activation.
Protective effect of trichostatin A on CD19+CD5+CD1dhigh regulatory B cells in heart transplantation

Field: Medicine (Health Sciences)

Heart transplantation is widely used for the treatment of several heart diseases. Regulatory B cells (Breg cells) serve a critical role in immune tolerance. However, the role of Breg cells in immune tolerance in the context of allogeneic heart transplantation remains poorly understood. The present study aimed to explore the effect of histone deacetylase (HDAC) inhibitor trichostatin A (TSA)‑regulated Breg on the regulation of immune tolerance in heart transplantation. By constructing anallogeneic heart transplantation mouse model, and performing flow cytometry, reverse transcription‑quantitative PCR, western blotting and carboxyfluorescein succinimidyl esterstaining assays, TSA‑regulated Breg cells and their effects on immune tolerance in heart transplantation were evaluated. The results demonstrated that TSA increased the frequency of CD19+CD5+CD1dhigh Breg cells both in vitro and in vivo. Moreover, TSA treatment increased the frequency of IL‑10 and TGF‑β‑producing CD19+CD5+CD1dhigh Breg cells, and IL‑10 and TGF‑β levels in vitro and in vivo. TSA administration significantly prolonged the survival rate in a heart transplant experiment model. In addition, the IL‑10 inhibitor ammonium trichloro(dioxoethylene‑o,o')tellurate partially reduced the survival rate and the percentages of CD19+CD5+CD1dhigh Breg cells in mice receiving heart allografts. In contrast, anti‑CD20 treatment significantly decreased the survival rate in these mice. Collectively, the present findings suggested that TSA may induce immune tolerance following heart transplantation by regulating CD19+CD5+CD1dhigh Breg cells. These results provide a theoretical basis for the prevention of immunological rejection in cardiac transplantation.
Therapies to Combat Co-Infection of HIV and Malaria during Pregnancy in Sub-Saharan Africa

Field: Medicine (Health Sciences)

In sub-Saharan Africa where Plasmodium falciparum malaria is endemic, 80% of the world's HIV-infected persons reside, making co-infection with these two major human pathogens a common occurrence.Pregnancy is a condition that produces an immunosuppressed state in the mother, which, in combination with an immune compromising disease such as HIV/AIDS, can lead to an increased risk of contracting infectious diseases such as malaria.Co-infection during pregnancy can lead to a number of poor outcomes for both mother and child.There has been little research into the implications of pregnancy and/or co-infection with regard to treatment of HIV/AIDS or malaria, and as a result the options for efficacious drug therapy during gestation are limited.In light of this, prophylactic measures are being investigated, including a vaccine for pregnant women or those planning a family that aims to reduce or prevent the adverse effects of malaria and/or HIV/AIDS.This review discusses the pressing need for treatment, outlines the incumbent difficulties in production of an effective chemotherapeutic or immunization regimen, and considers strategies for present and prospective vaccine development.
Serbia in the European culture routes

Field: Social Sciences (Social Sciences)

The article consists of two parts. The first section discusses the elements of contextualization of the European cultural routes - the process of European identity and interpretation of European values and heritage, especially the relation between culture and politics of memory, as well as the mediation of history through heritage. The article further analyzes the historical conditions for the formation of cultural patterns in the area of present-day Serbia, within the circle of civilization, marked with contradictions along the East - West lines. It also underlines the ambivalence of value orientation of Serbia and the valorization of imperial heritage of this territory as a point of definition towards the modern European trends, particularly in the Balkans discourse. The second section provides an overview of the 'European cultural routes' and maps of alternative thematic framework for the participation of Serbia in the Council of Europe program, which will take into account the principles of cultural diversity and encompass a broader understanding of cultural heritage, as a way to establish a better understanding of the past and shared future.
THE USE OF AN ELECTRONIC BEET TO EVALUATE SUGAR BEET DAMAGE AT VARIOUS FORWARD SPEEDS OF A MECHANICAL HARVESTER

Field: Agricultural and Biological Sciences (Life Sciences)

Mechanical harvesting strongly affects the quality of sugar beets, mainly in terms of root injuries, tare, andextracted sugar. In Mediterranean countries, the effects of sugar beet damage are more critical because of the warm andhumid climate at harvesting time. In order to investigate the dynamic interaction between mechanical tools and roots,electronic devices have been developed in some European countries for measuring impacts experienced by roots when passingthrough the harvesters. At the University of Bologna, an electronic beet with a 4905 m/s 2 triaxial accelerometer wasdeveloped in 1998. This device was used in a field trial for measuring and recording impacts in terms of peak acceleration,duration, and velocity change during impact. The device was placed into the soil in place of a real beet and then harvestedby a sixrow selfpropelled harvester, which was tested at four different forward speeds. Assessments of the level of damageon the harvested sugar beets were also carried out according to the IIRB international method. The aim of the study was toevaluate how different forward speeds tested on a single harvester can affect damage to the roots, to assess the damage causedat each step of the harvesting process, and to find a correlation between damage and impacts.
Mechanical parameters recorded by the electronic beet were referenced to three specific positions, defined as A, B, andC zones, within the harvester. The ANOVA results in A zone, composed of lifting shares and roller bed, and in B zone, composedof transfer web and turbines, showed a statistical significance. In C zone, composed of tank elevator and tank, the variableshad no statistical significance. The results of the trial showed that A zone had the highest values of the variables. A harvesterforward speed of 6 km/h caused the fewest taproot breaks and bruises. A linear model describing the relationship betweentaproot breaks and impact velocity change showed a statistical significance for A zone, while no significance was determinedfor B zone.
RESEARCH ON THE PROPERTIES OF PROTEASE FROM BACILLUS STRAIN BLYS-1

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

We extracted a protease from a Bacillus strain BLYS-1,and discussed the effects of different factors,such as pH value,temperature,organic solvents,metal ions,oxidant and EDTA,on the protease.The results showed that the protease from Bacillus strain BLYS-1 had resistance to acid,alkali and oxidant,and had higher activity in the pH range of 5 to 8;the best pH value was 7; the best reaction temperature was 50 ℃;and the protease was precipitated completely by ammonium sulfate with the 70% degree of saturation.The organic solvents,such as tween-20 and isopropyl alcohol,the denaturant SDS,and the metal ions,such as Sn2+,Ca2+,Ni+,had higher effect in inhibiting the protease,but Mg2+ and Zn2+ had the promotion effect.Based on the casein substrate,the paper determined the kinetic parameter Km of the protease was 2.53 g/L,and Vmax 6.67 μg/s.
Dairy cattle welfare in spring-calving, pasture-based systems

Field: Veterinary (Health Sciences)

Little research has been conducted on dairy cattle welfare within the Irish springcalving, pasture-based system. A welfare assessment was conducted on 82 Irish dairy farms to determine the herd-level prevalence of seven animal-based indicators of welfare and identify baseline performance benchmarks. Farms were visited during both the summer-grazing and winter-housing periods. At each visit, the 2019 milking herd was scored for body condition (BCS), locomotion, ocular and nasal discharge, tail injuries, integument damage, and avoidance response. For each indicator, the range in mean performance of the top (T) and bottom (B) 20% of farms was identified for grazing and housing. At grazing, farms displayed: 0-4% (T), 20-72% (B) of cows outside BCS targets; 1-5% (T), 15-32% (B) lameness; 0% (T), 79-96% (B) ocular discharge; 2-15% (T), 44-86% (B) nasal discharge; 0-3% (T), 2-52% (B) tail injuries; 0-2% (T), 12-29% (B) integument damage; 51-74% (T), 91-100% (B) avoidance response >1m. Similar levels of lameness, ocular discharge and tail injuries were observed between visits, however, significant differences were found for BCS, nasal discharge, integument damage and avoidance response. During housing, farms displayed: 4-12% (T), 33-71% (B) of cows outside BCS targets; 2-16% (T), 53-89% (B) nasal discharge; 4-14% (T), 29-49% (B) integument damage; 4-60% (T), 61-100% (B) avoidance response >1m. Performance of the top 20% of farms represents achievable targets that farms within the Irish dairy system should strive to meet or exceed. Continuation of this research focuses on determining risk factors for specific welfare problems to further improve dairy cattle well-being.
Hordeum vulgare L. subsp. vulgare AGG 103481 BARL

Field: Agricultural and Biological Sciences (Life Sciences)

Plant Genetic Resource.
Taxonomy: Hordeum vulgare L. subsp. vulgare
Common name(s): Barley
Other names: WABAR2175/VB0105*12 05-083D-394
Conserved by: Australian Grains Genebank, DEECA (AGG), Australia
Local sample unique identifier: AGG 103481 BARL
Method of creation: Acquisition
Date: 2017-06-01
Historical: No
Biological status: Genetic stock
MLS status: Not included
The production and distribution of digital content in China. An historical account of the role of internet companies and videogames

Field: Business, Management and Accounting (Social Sciences)

Purpose This paper aims to shed some light on the history of the Chinese videogames industry, to document the growth of the leading companies and reveal how they have been morphing into platforms delivering constellations of apps and digital content (audiovisual, films, music, literature, video streaming […]). The paper tracks the development of digital services through the prism of videogames thereby showing how this industry emerged out of the deployment of the internet. Design/methodology/approach The paper provides an overview and a synthesis of what is known about the Chinese game industry, particularly based on consultancy documents and publications from firms. The paper is based on desk research, a review of literature and trade press and the analysis of the annual reports of the leading players (NetEase, Tencent […]). Findings The rise of videogames and the creation of specific company’s “ecosystems” illustrate the capacity of the industry to innovate and its significance for the Chinese economy. It reveals that gaming has been a cornerstone of many Chinese technology companies. The (young) companies came up with the innovative business models (FTP, virtual items) that were required to further expand the market. They found new ways to interact with their customers through communities and various tools. Research limitations/implications The paper relies on consultancy documents and publications from firms on heterogeneous data from industry and consultants. This approach comes with some limitations from a methodological viewpoint. It allows documenting the historical trends and describing the industrial landscape but not to qualify the relationships among players. Besides, the use of these sources leads to a greater focus on business models and a more limited one on the policy dimension. The latter is often perceived only through the glasses of the companies. Practical implications The data provided are meant to be useful to become familiar with the Chinese games industry. Social implications The paper indicates that the online game industry is a complex web of activities with tensions and contradictions between stakeholders (industry, government and consumers). In the case of China, there is a conflict between the willingness to liberalize the economy and the will to maintain an ideological monopoly through cultural industries. Originality/value Little research has been devoted to the role of videogames in emerging economies, to its specific features and to the relationships with the media industry and the information and communications technology sector. The contribution of this “digital native” to the production and distribution of digital content remains less studied. The paper provides an up-to-date overview of the Chinese case.
Education level and outcomes after acute myocardial infarction in China

Field: Medicine (Health Sciences)

Objective To assess the association between educational attainment and acute myocardial infarction (AMI) outcomes in China to inform future healthcare interventions. Methods We used data from the China Patient-centred Evaluative Assessment of Cardiac Events-Prospective AMI study of 3369 consecutive patients hospitalised with AMI from 53 hospitals. Educational attainment was categorised as: high (senior high school, college or postgraduate degree), intermediate (junior high school) or low (primary school or illiterate). We used survival models to assess the relationship between education and 1-year major adverse cardiovascular events (MACE), all-cause mortality, both unadjusted and after adjustment for demographic characteristics and cardiovascular risk factors. Results The median participant age was 61 (52, 69) years, 23.2% were women, and 33.3% had high, 32.4% intermediate and 34.3% low educational attainment. In unadjusted analysis, compared with high educational attainment, low educational attainment was associated with a higher 1-year risk of MACE (HR 2.41, 95% CI 1.72 to 3.37) and death (HR for low vs high education 3.09, 95% CI 1.69 to 5.65). In risk-adjusted analyses, the association between education and death was attenuated and no longer statistically significant (adjusted HR 1.41, 95% CI 0.74 to 2.69, p=0.30). However, the risk of 1-year MACE (adjusted HR 1.68, 95% CI 1.18 to 2.41, p=0.004) remained significantly greaterin low educational attainment group. Conclusions In a national Chinese cohort of patients hospitalised with AMI, low educational attainment was associated with a higher risk of adverse events in the year following discharge. This association highlights the need to consider interventions to improve AMI outcomes in adults with low levels of education. Clinical trial registration NCT01624909 ; Results.