jimnoneill/paper-to-field-training huggingface dataset:
Structure of the Human Lactoferrin Gene and Its Chromosomal Localization

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The complete gene encoding the human lactoferrin (hLf) was isolated from a cosmid library and its structure was characterized. A detailed restriction map and the complete exon-intron structure of the gene are presented. The transcript is assembled from 17 exons like the bovine (bLf) and murine lactoferrin (mLf) genes, which are separated by introns ranging in size from about 300 bp to 3.3 kb. The total length of the gene is about 24.5 kb, estimated by adding up the sizes of the exons and introns. A comparison of the structure of the hLf gene with that of other species revealed that the hLf gene is more closely related to bLf than to mLf. The positions of the introns were well matched with those of the bLf gene except only for exons 14 and 15, wherein exon 14 of the hLf gene is one nt shorter while exon 15 is one nt longer than the bLf gene. All the exon-intron boundaries of the gene conformed to the GT/AG rule. In situ fluorescence hybridization indicated that the hLf gene was mapped in the region 3p21.3.
Population and spatial dynamics of desert bighorn sheep in Grand Canyon during an outbreak of respiratory pneumonia

Field: Agricultural and Biological Sciences (Life Sciences)

Introduction Terrestrial species in riverine ecosystems face unique constraints leading to diverging patterns of population structure, connectivity, and disease dynamics. Desert bighorn sheep ( Ovis canadensis nelsoni ) in Grand Canyon National Park, a large native population in the southwestern USA, offer a unique opportunity to evaluate population patterns and processes in a remote riverine system with ongoing anthropogenic impacts. We integrated non-invasive, invasive, and citizen-science methods to address questions on abundance, distribution, disease status, genetic structure, and habitat fragmentation. Methods We compiled bighorn sightings collected during river trips by park staff, commercial guides, and private citizens from 2000–2018 and captured bighorn in 2010–2016 to deploy GPS collars and test for disease. From 2011–2015, we non-invasively collected fecal samples and genotyped them at 9–16 microsatellite loci for individual identification and genetic structure. We used assignment tests to evaluate genetic structure and identify subpopulations, then estimated gene flow and recent migration to evaluate fragmentation. We used spatial capture-recapture to estimate annual population size, distribution, and trends after accounting for spatial variation in detection with a resource selection function model. Results and discussion From 2010–2018, 3,176 sightings of bighorn were reported, with sightings of 56–145 bighorn annually on formal surveys. From 2012–2016, bighorn exhibiting signs of respiratory disease were observed along the river throughout the park. Of 25 captured individuals, 56% were infected by Mycoplasma ovipneumoniae , a key respiratory pathogen, and 81% were recently exposed. Pellet sampling for population estimation from 2011–2015 yielded 1,250 genotypes and 453 individuals. We detected 6 genetic clusters that exhibited mild to moderate genetic structure ( F ST 0.022–0.126). The river, distance, and likely topography restricted recent gene flow, but we detected cross-river movements in one section via genetic recaptures, no subpopulation appeared completely isolated, and genetic diversity was among the highest reported. Recolonization of one large stretch of currently empty habitat appears limited by the constrained topology of this system. Annual population estimates ranged 536–552 (95% CrI range 451–647), lamb:ewe ratios varied, and no significant population decline was detected. We provide a multi-method sampling framework useful for sampling other wildlife in remote riverine systems.
Bibasic Sequences and Norming Basic Sequences

Field: Mathematics (Physical Sciences)

It is shown that every infinite dimensional Banach space X contains a basic sequence $({x_n})$ having biorthogonal functionals $({f_n}) \subset {X^\ast }$ such that $({f_n})$ is also basic. If $[{f_n}]$ norms $[{x_n}]$ then $({f_n})$ is necessarily basic. If $[{f_n}]$ norms $[{x_n}]$ then $[{x_n}]$ norms $[{f_n}]$. In order that $[{f_n}]$ norms $[{x_n}]$ it is necessary and sufficient that the operators ${S_n}x = \Sigma _1^n{f_i}(x){x_i}$ be uniformly bounded. If $[{f_n}]$ norms $[{x_n}]$ then ${X^\ast }$ has a complemented subspace isomorphic to ${[{x_n}]^\ast }$. Examples are given to show that $({f_n})$ need not be basic and, if $({f_n})$ is basic, still $[{f_n}]$ need not norm $[{x_n}]$.
Intrahepatic lymphocyte phenotypes in hepatitis C virus infection: a comparison between cirrhotic and non-cirrhotic livers.

Field: Medicine (Health Sciences)

In hepatitis C, lobular mononuclear cells are mostly macrophages and appear associated with bridging fibrosis. Cirrhotic livers display significantly lower numbers of lobular CD4 and CD8 lymphocytes. This finding could help explain a decrease in immune surveillance and the promotion of neoplastic growth in HCV-associated cirrhosis.
Managing knowledge through social media

Field: Business, Management and Accounting (Social Sciences)

Purpose The purpose of this paper is to conceptualise social media usage (SMU) as a contributory, knowledge management (KM) tool towards entrepreneurial behaviour amongst small- and medium-sized enterprises (SMEs). Although an underdeveloped concept in entrepreneurship, the conceptual analysis of KM presents evidence which links SMU as complementary to changing KM conventions. Design/methodology/approach The pertinent KM and SMU literatures of the SME context were reviewed to form an understanding of this context. Employing a mixed-methods approach, a pragmatic, thematic investigation of SMU-enhanced KM was facilitated. Findings Substantial benefits of innovative SMU, as a management tool towards SME entrepreneurialism, were witnessed. SMU enhances the administration of real-time knowledge, encouraging creativity. However, longer-term costs of employing requisite personnel, and anticipated organisational restructuring, present challenges. The paper identifies the potentials of social media technologies in overcoming KM issues. The authors propose a reasoned process model towards entrepreneurial exploitation by acknowledging systematic phases of research, concept, institutionalise, develop, target and assess, referred to as the RCIDTA model. Practical implications The authors argue that KM, through social media, facilitates interactions to execute innovative processes within SMEs ever-changing infrastructures. It also informs nascent entrepreneurs, in considering the benefits of systematic KM, and novel SMU, opportunities. The RCIDTA model for SMEs can be utilised in improving knowledge ecosystems of entrepreneurial SMEs, promoting innovation towards sustained organisation growth. Originality/value This paper embraces the growing approach of SMEs applying SMU. SMU and its cost efficiency support the start-up activity. This paper highlights central issues concerning the exploitation of sector-specific KM, including organisational strategy, structure, brand formation, fiscal and personnel resource allocation and market share.
Drug-drug Interaction Prediction with Common Structural Patterns

Field: Computer Science (Physical Sciences)

Substructures of drugs are important for drug-drug interaction (DDI) prediction because drugs with similar chemical structures are prone to share similar properties. There are common substructures (i.e., functional groups) that play significant roles in DDI prediction. However, the existing computational methods can't fully utilize common structural patterns between drugs for DDI prediction. In this paper, we develop a substructure-based framework named StructDDI which can fully utilize common structural patterns between drugs. A graph processing method based on the random walk is proposed to generate the representation of drugs. A novel feature extraction component that includes dual convolutional neural networks (CNNs) is proposed to automatically summarize structural and chemical representation. The proposed StructDDI was evaluated on two real-world datasets and performed better than state-of-the-art baselines.
A Design of an Interactive Multimedia Learning Environment for Supporting Reading Skills of Deaf Individuals

Field: Health Professions (Health Sciences)

Language learning is a process related to the skills in speaking, listening and learning to read and write. Reading is an activity in which humans acquire information and is therefore essential for deaf children. The purpose of this paper is to develop an interactive multimedia learning environment to promote reading skills for deaf children based on see and learn. The authors of this study focus on the idea that children should have the potential to develop learning to read based on the conceptual framework of see and learn which provides a framework for multi-media learning tools for deaf individuals. The main goal of this study is to incorporate first (sign language) and second spoken language skills as bilingual programs adapted from the hearing population model. Of particular interest is the nature of visual communication in relation to meaning, memory and identity. The study combines bilingual, visual and an interactive multi-media learning environment (tool) to improve individual performance for deaf children. One mode uses text graphics to read Thai language by signing and with pictures. A second mode is used to recognize meaning from sign language and pictures. This paper posits that deaf individuals can learn Thai written language and Thai sign language at the same time. The researchers found that deaf individuals can learn to read using the sign language picture story technique. The context of the story can be perceived through the text meaning and help children learn another language through picture and sign language. This current paper studies deaf children aged 10-13 years. The results confirm the expectation that deaf individuals can learn Thai-written
A NEW PARASITIC DISEASE OF THE JUNCACEAE—PRELIMINARY NOTICE

Field: Agricultural and Biological Sciences (Life Sciences)

Journal Article A NEW PARASITIC DISEASE OF THE JUNCACEAE—PRELIMINARY NOTICE Get access E. J. SCHWARTZ E. J. SCHWARTZ Search for other works by this author on: Oxford Academic PubMed Google Scholar Annals of Botany, Volume os-24, Issue 1, January 1910, Page 236, https://doi.org/10.1093/oxfordjournals.aob.a089261 Published: 01 January 1910
20(S)-Ginsenoside Rg<sub>3</sub> Inhibits Human Glioma Cell Growth through the Suppression of Voltage-Gated K<sup>+</sup> Channels

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Previous studies demonstrated that 20(S)-ginsenoside Rg3 (20S-Rg3) could effectively inhibit tumor cell proliferation as well as K + channel currents expressed in xenopus oocytes. However, the effect of 20S-Rg3 on the growth of human glioma cells and the ion channels expressed in tumor cells was rarely reported in the literature. In the present study, we investigated the effect and the underlying mechanism of 20S-Rg3 on cell proliferation and apoptosis of human glioma U87-MG cells. I n vitro results exhibited that 20S-Rg3 had potent cytotoxic effect and significantly inhibited the proliferation of U87-MG cells in a dose-and time-dependent manner. Typical arrest at G 2 /M phase was induced, and the apoptosis rate of U87-MG cells was significantly higher in the 20S-Rg3 treatment group than in the control group. Electrophysiological results showed that 80 μmol/L 20S-Rg3 substantially inhibited voltage-gated K + currents of U87-MG cells. Together, these results suggest that the suppression of voltage-gated K + currents might play an important role in the 20S-Rg3-induced cell death, and these new findings provide useful data for further study of the antitumor effect of 20S-Rg3.
Ethylene-Inducible AP2/ERF Transcription Factor Promotes Capsaicinoid Biosynthesis in Capsicum

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Ethylene is very important in the process of plant development and regulates the biosynthesis of a lot of secondary metabolites. In these regulatory mechanisms, transcription factors that mediate ethylene signals play a very important role. Capsaicinoids (CAPs) only synthesized and accumulated in Capsicum species, causing their fruit to have a special pungent taste, which can protect against attack from herbivores and pathogens. In this study, we identified the transcription factor CcERF2 , which is induced by ethylene, and demonstrated its regulatory effect on CAPs biosynthesis. Transcriptome sequencing analysis revealed the expression patterns of CcERF2 and multiple genes associated to CAPs biosynthesis were basically the same. The spatiotemporal expression results showed CcERF2 was preferentially expressed in the placenta of the spicy fruit. Ethylene can induce the expression of CcERF2 and CAPs biosynthesis genes (CBGs). CcERF2 gene silenced, 1-MCP and PZA treatments caused a decrease in expression of CBGs and a sharp decrease in content of CAPs. The results indicated CcERF2 was associated with the CAPs biosynthesis.
Relationship FoMO and Nomophobia with Social Anxiety Symptoms in the Use of Social Media at UMP

Field: Psychology (Social Sciences)

Background:Along with the increase in social media users, people are also starting to experience what is called social anxiety. This social anxiety is caused by feelilngs of worry or fear of the judgment of others. This causes individuals who experience social anxiety to try to avoid social situations so that they can avoid the negative judgments of other. Anxiety about the judgment of others in one of the main symptoms of social anxiety. In addition, people who frequently use social media tend to like to compare themselves with others. Method: This research is a quantitative study with a cross-sectional approach. The sample used in this study was undergraduate nursing students at Muhammadiyah University in Purwokerto with a total of 99 respondents. There were 3 instruments used in this study, namely the SAS-SMU questionnaire, the FoMO’s questionnaire, and the NMP-Q questionnaire. Results: The results of the analysis of the relationship using the chi-square statistical test found p=0.000(p<0.05),meaning that there is asignificant relationship between FoMO and symptoms of social anxiety in the use of socialmedia. The results of the relationship analysis using the chi-square statistical testfound p=0.001 (p<0.05), meaning that there is a significant relationship between Nomophobia and symptoms of social anxiety in the use of social media. Conclusion:There is a significant relationship between FoMO and symptoms ofsocial anxiety in using social media and there is also a significant relationship between Nomophobia and symptoms of social anxiety in using social media.
Rationale for an ecological risk approach for South African water resource management

Field: Environmental Science (Physical Sciences)

The principle of ecosystem protection in the South African Water Act requires that water resource management tools for a multiple stressor environment be tailored to the characteristics of the aquatic ecosystem. The requirements of the Act, the characteristics of aquatic ecosystems as well as co-occurrence of diverse stressors are considered. Although single substance criteria have a useful role, they are not sufficient for resource management within the context of the ecological reserve. It is proposed that an effect-likelihood approach has the potential to address the variability and uncertainty in management of a surface water body subject to multiple stressors. An in-stream receiving water risk objective approach might be considered. WaterSA Vol.27(3) 2001: 283-292
Occurrence Download

Field: Agricultural and Biological Sciences (Life Sciences)

A dataset containing 338 species occurrences available in GBIF matching the query: { "TaxonKey" : [ "is Knautia orientalis L." ] } The dataset includes 338 records from 54 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0035386-240321170329656/datasets/export for details. Data from some individual datasets included in this download may be licensed under less restrictive terms.
F60 Q-Motor foot tapping: novel setup to increase reliability

Field: Medicine (Health Sciences)

Background

Q-Motor provided reliable quantitative endpoints in TRACK-HD and several clinical trials. Finger tapping was the most sensitive assessment of disease progression and to detect treatment effects. Recently a foot tapping test was introduced to expand Q-Motor to the lower extremity. However, subjects had difficulties to properly lift the foot from the force sensor.

Aims

To assess the feasibility of using a novel foot tapping apparatus that requires subjects to lift their foot properly.

Methods

Two novel setups were constructed with the force sensor above the foot, one using a rigid (G1), one with a non-rigid bar (G2) to carry the sensor. Both setups were compared with the old setup carrying the sensor underneath the foot (G3). 6 healthy controls were asked to perform the foot tapping task on each setup on 4 consecutive days. They tapped with the foot on the force sensor as fast as possible for 10 seconds with 5 repetitions at each foot.

Results

The 'Tap-Speed-Inter-Onset-Interval-Mean-Foot' is the main endpoint of foot tapping. It is the average time between the start of each successive tap. A density plot showed normally distributed data only for G2 and G3, thus G1 was not analyzed further. The data showed that the new inverted test setup (G2) provided less variability and better reproducibility over time.

Conclusions

The novel foot tapping task is feasible and provided more reliable data. The new setup with the non-rigid bar merits further exploration in upcoming studies and should be tested in a larger cohort of subjects over longer periods.
X-ray photoelectron spectroscopy study of excimer laser treated alumina films

Field: Materials Science (Physical Sciences)

Amorphous alumina layers are deposited on a single crystal Si substrate by a e-gun evaporation technique. These films are then thermally annealed in oxygen to be crystallized and, further, irradiated with an excimer laser beam. At each stage of the film preparation, an x-ray photoelectron spectroscopy analysis is performed at the film surface and in depth, upon ion beam grinding. Results give evidence for the formation of an aluminosilicate upon thermal annealing of the film in oxygen. At the surface itself, this compound is observed to decompose upon excimer laser irradiation at energy densities exceeding 1.75 J/cm2, giving rise to free Si atoms and SiO2, however with complete disappearance of Al atoms. Model photochemical reactions are proposed to explain such transformations.
Engendered Perceptions About Surgeon Gender and Patient Outcomes After Cesarean Delivery

Field: Medicine (Health Sciences)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Energy Transfer on Demand: Photoswitch-Directed Behavior of Metal–Porphyrin Frameworks

Field: Chemistry (Physical Sciences)

In this paper, a photochromic diarylethene-based derivative that is coordinatively immobilized within an extended porphyrin framework is shown to maintain its photoswitchable behavior and to direct the photophysical properties of the host. In particular, emission of a framework composed of bis(5-pyridyl-2-methyl-3-thienyl)cyclopentene (BPMTC) and tetrakis(4-carboxyphenyl)porphyrin (H4TCPP) ligands anchored by Zn(2+) ions can be altered as a function of incident light. We attribute the observed cyclic fluorescence behavior of the synthesized porphyrin-BPMTC array to activation of energy transfer (ET) pathways through BPMTC photoisomerization. Time-resolved photoluminescence measurements show a decrease in average porphyrin emission lifetime upon BPMTC insertion, consistent with an ET-based mechanism. These studies portend the possible utilization of photochromic ligands to direct chromophore behavior in large light-harvesting ensembles.
Molecular Dynamics And Circular Dichroism Studies On Aurein 1.2 And Retro Analog

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Aurein 1.2 is a 13-residue amphipathic peptide with antibacterial and anticancer activity. Aurein1.2 and its retro analog were synthesized to study the activity of the peptides in relation to their structure. The antibacterial test result showed the retro-analog is inactive. The secondary structural analysis by CD spectra indicated that both of the peptides at TFE/Water adopt alpha-helical conformation. MD simulation was performed on aurein 1.2 and retro-analog in water and TFE in order to analyse the factors that are involved in the activity difference between retro and the native peptide. The simulation results are discussed and validated in the light of experimental data from the CD experiment. Both of the peptides showed a relatively similar pattern for their hydrophobicity, hydrophilicity, solvent accessible surfaces, and solvent accessible hydrophobic surfaces. However, they showed different in directions of dipole moment of peptides. Also, Our results further indicate that the reversion of the amino acid sequence affects flexibility .The data also showed that factors causing structural rigidity may decrease the activity. Consequently, our finding suggests that in the case of sequence-reversed peptide strategy, one has to pay attention to the role of amino acid sequence order in making flexibility and role of dipole moment direction in peptide activity. KeywordsAntimicrobial peptides, retro, molecular dynamic, circular dichroism.
LTE network planning based on game theory

Field: Computer Science (Physical Sciences)

LTE network planning mainly contains two contents: base stations' position and their power allocation. Traffic search method is used to determine base station position and initial power. For the base station power allocation, we induce the game theory. To avoid the non-cooperate game theory's shortcome, we consider the cooperation game theory, namely, base stations can exchange a few information. Simulations demonstrate that it is convergence and improve the performance due to the update of power and interference price per iterate.