jimnoneill/paper-to-field-training huggingface dataset:
Prevention & Management of Herpes Zoster- an Update

Field: Medicine (Health Sciences)

Herpes zoster (commonly referred to as "shingles") results .from reactivation of the varicella-zoster virus infection, or chickenpox. Were as varicella is generally a disease of childhood, herpes zoster becomes more common with increasing age Factors that decrease immune function, such as human immunodeficiency virus infection, chemotherapv, malignancies and chronic corticosteroid use, may also increase the risk of developing herpes zoster. Reactivation of latent varicella-zoster virus from dorsal root ganglia is responsible.for lhe classic dermatomal rash and pain that occur with herpes zoster. Burning pain typically precedes the rash by several days and can persist for several months after the rash resolves. With post herpetic neuralgia, a complication of herpes zoster, pain may persist well after resolution of the rash and can be highly debilitating. Although the diagnosis of the conditions is generally straightforward, treatment can be frustrating for the patient and physician. Approaches to management include treatment of the herpes zoster infection and associated pain, prevention of post herpetic neuralgia, and control of the neuropathic pain until the condition resolves. Herpes zoster is contagious to those who have not had varicella or have not received the varicella vaccine. The role of the varicella vaccine in preventing herpes zoster is uncertain, but is being studied. The management of herpes zoster is challenging because many patients develop troublesome complication. So, appropriate management o/'herpes zoster is very important to avoid complication. On the other hand prevention is better than cure. Immunization with varicella zoster virus vaccine may boost humoral and cell mediated and decrease the incidence of zoster in population. So effectiveness of a vaccination program need to be evaluated. immunity DOI: http://dx.doi.org/10.3329/bmj.v41i3.18961 Bangladesh Medical Journal 2012 Vol.41(3): 53-56
Geodesic Distance Descriptors

Field: Mathematics (Physical Sciences)

The Gromov-Hausdorff (GH) distance is traditionally used for measuring distances between metric spaces. It is defined as the minimal distortion of embedding one surface into the other, while the optimal correspondence can be described as the map that minimizes this distortion. Solving such a minimization is a hard combinatorial problem that requires pre-computation and storing of all pairwise geodesic distances for the matched surfaces. A popular way for compact representation of functions on surfaces is by projecting them into the leading eigenfunctions of the Laplace-Beltrami Operator (LBO). When truncated, The basis of the LBO is known to be the optimal for representing functions with bounded gradient in a min-max sense. Methods such as Spectral-GMDS exploit this idea to simplify and efficiently approximate a minimization related to the GH distance by operating in the truncated spectral domain, and obtain state of the art results for matching of nearly isometric shapes. However, when considering only a specific set of functions on the surface, such as geodesic distances, an optimized basis could be considered as an even better alternative. Here, we define the geodesic distance basis, which is optimal for compact approximation of geodesic distances, in terms of Frobenius norm. We use the suggested basis to extract the Geodesic Distance Descriptor (GDD), which encodes the geodesic distances information as a linear combination of the basis functions. We then show how these ideas can be used to efficiently and accurately approximate the metric spaces matching problem with almost no loss of information. These observations are used to construct a very simple and efficient procedure for shape correspondence. Experimental results show that the GDD improves both accuracy and efficiency of state of the art shape matching procedures.
Abstract P377: Oral Estrogen Hormone Therapy Use after Incident Venous Thrombosis and the Risk of Recurrence

Field: Medicine (Health Sciences)

Background: Oral estrogen hormone therapy (HT) is associated with a 2-fold increased risk of incident venous thrombosis (VT). Patterns of HT use following an incident VT and the association between HT use and recurrence are poorly characterized. Objectives: We aimed: (1) to characterize the use of oral estrogen HT in the 5 months following a first VT event; and (2) to evaluate whether the use of HT following an incident VT is associated with VT recurrence. Methods: In Group Health Cooperative (GHC), an integrated health care system, we identified an inception cohort of women aged 40-89 who experienced an incident VT from 2002 to 2010 (n=1,121). Using medical record review, we followed participants for VT recurrence, defined by physician diagnosis >2 weeks after the incident VT with clinical and/or imaging evidence of a new or expanded clot. HT use at 80% compliance was defined using GHC computerized pharmacy data. Characterization of HT use was restricted to women who survived for ≥5 months. Cox proportional hazards models were used to evaluate the association between time-varying current HT use and risk of recurrent VT, adjusting for race, baseline age, BMI, idiopathic incident VT, diabetes status, and the following time-varying covariates: cancer, CVD, and current anticoagulation use. In primary analyses, time was defined as days since incident event and censoring occurred at last follow-up or death. To evaluate the influence of possible HT misclassification soon after the incident event, we conducted 2 sensitivity analyses in which women entered the risk set after 30 and 60 days post-incident VT. Additional secondary Cox analyses were restricted to current HT users at the time of incident VT. Results: Of women who survived ≥5 months post-incident VT (n=993), 12% used oral estrogen HT at time of the incident event (n=123); among these, 90 (73%) discontinued use whereas 33 (27%) continued to fill ≥1 HT prescription within the next 5 months. Compared with users who stopped HT, persistent users were on average older (70 vs. 65 years), had a lower BMI (29 vs. 32 kg/m 2 ), and were less likely to have experienced an incident PE as part of their first VT event (27% vs. 61%). Over an average follow-up of 3.4 years, we identified 164 recurrent VTs among 1,121 women. We found no evidence of an association between HT use after incident VT and VT recurrence risk, adjusted for confounders (HR=0.73; 95% CI: 0.26-1.99; p=0.53); no evidence of an association was found in sensitivity or secondary analyses. Conclusions: In this population of GHC enrollees, over one-quarter of oral estrogen HT users at VT incidence continued use and filled subsequent HT prescriptions in the 5 months following the incident event. We found no evidence of an association between post-event HT use and the risk of VT recurrence, however, the number of HT users in our population was small.
Tris(pyridine-κN)[salicylaldehyde (2-hydroxybenzoyl)hydrazonato-κ2N,O]nickel(II) pyridine sesquisolvate

Field: Chemistry (Physical Sciences)

In the title compound, [Ni(C14H10N2O3)(C5H5N)3]·1.5C5H5N, the NiII ion is coordinated by one N and two O atoms from a Schiff base ligand and by the N atoms of three pyridine mol­ecules to form a distorted octa­hedral geometry.
Outports under Threat: Systemic Roots of Social Crisis in Rural Newfoundland

Field: Social Sciences (Social Sciences)

This chapter examines the roots of the crisis in the disruption of an economic system that combined mutually-sustaining formal and informal sectors. It explains the response of local people to their contemporary circumstances as they attempt to construct an adequate way of life: some are planning to leave, others to stay. For an indefinite time, the economic mainstay of much of rural Newfoundland has disappeared, and people have had to reconstruct their lives on some other basis. Cod, redfish and various flatfish species comprise the groundfish on which fishing off Newfoundland concentrated in the current century until overtaken by shrimp and crab. The amount and value of production in the various communities reveal the complexity of the Newfoundland traditional household economy, its regional differentiations and the adjustments made to it over time. The household was the local unit of production in both formal and informal sectors.
Excitation energy sharing in binary peripheral heavy ion reactions at Fermi energies

Field: Physics and Astronomy (Physical Sciences)

Evidence for the dependence of excitation energy sharing between two heavy remnants on the difference in the lost mass in two-body peripheral heavy ion reactions at Fermi energy is presented, based on experimental results for the reactions 93Nb + 116Sn,116 Sn + 93Nb, and 93Nb + 93Nb at 38A MeV. An observable based on the experimental velocities of the heavy residues is used to select reactions with equal preevaporative masses of projectile-like fragments and target-like fragments. The excitation energy, evaluated by means of a complete average calorimetry, is found to be larger for the nucleus that finally retains a larger part of the hot interaction region.
MEFLOQUINE TREATMENT FOR UNCOMPLICATED FALCIPARUM MALARIA IN YOUNG CHILDREN 6–24 MONTHS OF AGE IN NORTHERN GHANA

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Mefloquine (MQ) single dose 20 mg/kg treatment of falciparum malaria was evaluated in 186 children of 6–24 months of age in northern Ghana. There were 15 RII/RIII-type parasitologic failures, all with Day 2 MQ blood levels significantly lower than children whose parasitemias cleared before Day 7 and remained clear through 28 days. Predictors of RII/RIII parasitologic response were vomiting after MQ dosing, Day 2 MQ levels < 500 ng/mL, and undetectable Day 2 levels of the carboxymefloquine metabolite. There were 50 cases of delayed RI parasitologic failure, but 71% of these cases had undetectable Day 28 blood levels of MQ and drug levels in the remaining 29% ranged below the 620 ng/mL level that suppresses MQ sensitive strains of P. falciparum. Drug levels among infants that tolerated MQ well were not associated with age, weight, hemoglobin, parasitemia, and pre-existing symptoms of vomiting or diarrhea. An observed recurrent parasitemia of 34,400 trophozoites/μL against a MQ blood concentration of 550 ng/mL was taken as indication of tolerance to suppressive levels of the drug at this location.
Technological Approaches to Screening and Case Finding for Depression

Field: Health Professions (Health Sciences)

What are the strengths and weaknesses of computer-based and other automated methods of detecting depression? Two promising technologies make use of the Internet and speech recognition. Whatever technology is used, each method needs to be assessed rigorously using the same high standards that have been applied to pencil-and-paper tests. We are in the midst of a technological revolution that inevitably will transform psychiatric clinical practice. A consensus for routine depression screening is building, and at the same time methods by which it could be accomplished are emerging. The hope is that the right technology can provide an easy, inexpensive, valid, and reliable public health approach to depression screening. Computerized assessment is well accepted in diverse fields, and the use of Internet-based survey technology has grown exponentially. Issues regarding the strengths and limitations of computerized assessments are addressed regularly in the literature. For example, such assessments have been shown to improve data quality while at the same time reducing cost as well as the time to score, analyze, and report results. Increasingly, as depressive disorders have been recognized as highly prevalent with significant morbidity, multiple screeners using an array of technological advances have been developed (Table 8.1 lists selected studies). This chapter will review the technologies that are currently available for automated depression screening and will discuss them in terms of criteria that should dictate their adoption. The growing list of technologies can be classified on several dimensions. Perhaps themostimportant of these isadaptivevs.non-adaptive. Inanadaptive technology pioneered by the Educational Testing Service, a computer, using a preprogrammed algorithm, decides which question to ask next given the responses so far. Paper-and-pencil is the classical non-adaptive technology— everyone gets the same paper with the same questions in the same order. Technological modality is a second dimension. Currently available technologies include the phone, the Internet, and hand-held electronic devices. The phone can be split into several groups, including agent: computer-assisted telephone interview (CATI), speech recognition, and touch-tone. Phone can also be classified as inbound (the patient initiates the call to a toll-free number) or outbound (the system initiates the call).
ChemInform Abstract: Palladium(0)‐Catalyzed Tandem Alkylation and SN′ Cyclization of 1,4‐ Dichlorobut‐2‐ene by the N‐(Diphenylmethyleneamino)acetonitrile. A Stereoselective Synthesis of 1‐Aminocyclopropanecarboxylic Acids.

Field: Chemistry (Physical Sciences)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthesis of a Series of Hydroxycarboxylic Acids as Standards for Oxidation of Nonanoic Acid

Field: Chemistry (Physical Sciences)

The synthesis of a series of nonanoic acids hydroxylated in terminal,ω-1,ω-2,ω-3 positions is described. These compounds will be employed as useful standards for the study of enzymatic and microbiological oxidation of nonanoic acid. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]
Depression of heme formation and production of free porphyrin in duck erythrocytes

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The effects of a number of substances that depress protoheme formation and affect free protoporphyrin production in duck erythrocytes in vitro were measured. The findings indicate that inhibition of some phase of porphyrin synthesis accounts for depression of heme formation by divalent lead and that inhibition of some phase of the conversion of porphyrin into heme accounts for depression of heme formation by pyridoxine and certain derivatives, adenosine, adenine, chloromycetin, benzimidazole and certain derivatives, and physostigmine. The compounds also inhibit porphyrin synthesis, but under certain conditions pyridoxamine phosphate and physostigmine stimulate porphyrin synthesis.
Studies on the effect of orchard floor management practices on quality parameters and leaf nutrient status in apricot (Prunus armeniacaL.) cv. New Castle

Field: Agricultural and Biological Sciences (Life Sciences)

An experiment was conducted at the experimental farm of Department of Pomology,Dr. Y. S. Parmar Univetsity of Horticulture and Foresty Nauni, Solan (H.P.) to study the effect of different orchard floor management practices on apricot fruit quality and leaf nutrient status. The application of grass mulch improved physico-chemical parameters of apricot fruits (fruit weight, fruit size, TSS, total sugars, reducing sugars, ascorbic acid, soluble proteins, total phenols and carotenoids) of apricot fruits as compared to all other treatments. Among the different orchard floor management practices the treatment of grass mulch increased the leaf macro (N,P,K and Mg) and micro (Fe,Cu,Zn and B) nutrient contents but the effect on Ca and Mn was found to be non-significant.
RESULTS OF CROSSBREEDING OF AYRSHIRE CATTLE

Field: Agricultural and Biological Sciences (Life Sciences)

The dynamics of growth and development of crossbred heifers obtained from bulls of Montbeliarde and Norwegian Red breeds, in comparison with purebred Ayrshire, have been studied. The highest influence of the father's breed on the bodyweight of daughters was found at 18 months of age (29.7%). Heifers were born as a result of crossing the Ayrshire breed with the Montbeliarde breed and had a higher body weight compared to the daughters of the Ayrshire bulls. The daughters of Montbeliarde bulls at 3 months weighed 2.9 kg more, at 6 months - by 4.0, at 9 months - by 6.3, at 12 months - by 20.1, in 15 months - by 41.3 and at 18 months by 49.8 kg (p <0.001). Heifers obtained as a result of crossing Ayrshires with a Norwegian Red breed were distinguished by even greater body weight than purebred Ayrshire. The advantage in body weight was: at 3 months of age 7.6 kg, at 6 months - 19.5, at 9 months - 38.9, at 12 months - 56.3, at 15 months - 70.1 and at 18 months - 70.9 kg. By the age of 9 months, the average daily gains of heifers obtained from Montbeliarde bulls were almost the same. During the period from 9 to 18 months, the daughters of Montbeliarde bulls prevailed over their peers in this indicator by 85-217 g (P <0.001), and daughters bulls of the Norwegian Red breed in the period from birth to 15 months of age - by 82-216 g (p <0.00). The average daily gain from birth to fruitful fertilization in purebred animals was 711 ± 5.4 g, in daughters of Montbeliarde bulls 799 ± 28.9 g, and in descendants of Norwegian Red bulls - 874 ± 12.1 (p <0.001). The age of first fertilization in purebred Ayrshire animals was 18.9 months, in the daughters of the Montbeliarde bulls - 17.0 months, and in the descendants of Norwegian Red bulls - 14.7 months. The age of first calving, respectively: 27.8 months, 25.8 months, and 23.7 months. The daughters of the Montbeliarde breed bulls at different ages had a greater survival rate by 7.3-10.1%, and the descendants of the Norwegian Red bulls by 3.7-9.2% compared to purebred Ayrshire (p>0.1). The dairy strength was better expressed in the first-calf heifers of the Ayrshire breed in comparison with the crossbred animals, and the corpus and udder - in the daughters of the Norwegian Red bulls.
Parasympathetic control of blood circulation and secretion in the nasal mucosa.

Field: Neuroscience (Life Sciences)

The effects of selective parasympathetic nerve activation on the secretory response and the vascular exchange and capacitance sections in the cat nasal mucosa were studied. The vascular events were investigated by measuring the local disappearnce of 125I- and changes in gross pulse rate from 131I- labelled serum albumin as monitored over the nose. A frequency-dependent increase in nasal secretion and local blood content occurred in the range 0.5-12 imp/sec: an increase in disappearance rate was observed at the same time. This indicates that the vascular and secretory responses are activated simultaneously. The secretory responses, but not the vascular events, were shown to be blocked by atropine. The results thus shown that the postganglionic parasympathetic mediator of nasal secretion is cholinergic, whereas the vasodilatation appears to be due to a different mechanism, which is not sensitieve to atropine. The beneficial effect of some antihistamines in vasomotor rhinitis may thus be due to their anticholinergic properties.
GROUNDING GEOGRAPHIES OF ECONOMIC GLOBALISATION: GLOBALISED SPACES IN CHILE'S NON‐TRADITIONAL EXPORT SECTOR, 1980–2005

Field: Social Sciences (Social Sciences)

ABSTRACT The debate around neoliberal globalisation and its impacts on economically peripheral countries has been waged by partisan forces to the right and left since the early 1990s. Much of this debate focuses at the scale of the nation‐state, or of the whole globe, and, while often sophisticated in an ideological sense, is scant in terms of consideration of the ‘grounded’ outcomes of the processes and discourses of globalisation. This paper argues that an appreciation of the contingent economic geography and political economy of any given local and regional transformation is essential for understanding the outcomes of economic globalisation. In order to illustrate this, the paper analyses two regional non‐traditional agricultural export (NTAX) complexes in the highly globalised Chilean economy. By focusing on ‘hotspots’ or ‘globalised spaces’ at the regional and local scales we are able to cut through the rhetoric associated with generalised arguments for and against economic globalisation and illustrate that both the roots and impacts of the insertion into global commodity complexes are highly geographically contingent. Our analysis concludes that NTAX development in Chile over the past 25 years has radically restructured local and regional economies, has concentrated wealth ‘extra‐regionally’, has exacerbated social differentiation, and threatens environmental sustainability. We argue that policy that seeks to address these trends requires more grounded consideration of the complex and uneven geography of economic globalisation that does not privilege analysis at any one scale and that seeks to elucidate the links between the ‘global’ and the ‘local’.
Epidemiology of Lower Urinary Tract Symptoms: Emphasis on the Status in Korea

Field: Medicine (Health Sciences)

A comprehensive and correct understanding of epidemiologic finding about lower urinary tract symptoms (LUTS) is important for several reasons. First, LUTS are highly prevalent in both genders all around the world and are expected to be a major concern to physicians in the near future because of the rapid rise in the elderly population. Second, it is crucial to observe trends in prevalence when national health care policy is established. By using a Medline search with various terms related to LUTS and prevalence, a review of epidemiologic studies was undertaken with an emphasis on the status in Korea. Despite the suggestions made by the International Continence Society, the lack of uniform definitions and the lack of a unified threshold of symptoms are the biggest obstacles in epidemiologic study with regard to LUTS. Most Korean epidemiologic studies on LUTS have been reported since 2000 and reveal that the prevalences of specific clinical conditions, such as LUTS, benign prostatic hyperplasia, overactive bladder, and detrusor underactivity, are in line with prevalences in Western counties. However, the prevalence of nocturia is somewhat different from that in Western countries. Many epidemiologic studies of LUTS have provided us with valuable information and a better understanding of the clinical conditions. Given that the impact of these clinical conditions on quality of life and health care cost will be emphasized more in the near future, more studies on optimal management approaches to LUTS are needed on the basis of this knowledge.
Youth representation in the European Parliament: The limited effect of political party characteristics

Field: Social Sciences (Social Sciences)

Which party characteristics contribute to the representation of young legislators? We examine this question quantitatively, focusing on the European Parliament (EP), and gauge the influence of the age of the party leader, the age of the party, the size of its support, party ideology and party nomination procedures on the age of politicians, based on data of all members who have served in the EP. We find that none of these characteristics matter substantively in explaining young representatives’ presence and discuss ways to further the field of research on youth representation. Online Appendix