jimnoneill/paper-to-field-training huggingface dataset:
The compare changes of motilin and calcinin gene related-peptide in chemotherapy for digestive tumor

Field: Medicine (Health Sciences)

目的 检测消化道肿瘤患者化疗前后和胃良性疾病者的血浆胃动素(MTL)、降钙素基因相关肽(CGRP)含量,了解化疗前后MTL、CGRP含量变化及其临床意义.方法 采用放射免疫分析法测定消化道肿瘤40例(其中胃癌16例,原发性肝癌8例,结、直肠癌8例,其他癌肿8例)及胃良性疾病患者20例的MTL、CGRP含量,并进行比较.结果 胃癌和结直肠癌化疗后血浆MTL均显著低于治疗前(P＜0.05),原发性肝癌和其他癌症患者血浆MTL含量化疗前后比较差异无统计学意义(P＞0.05);原发性肝癌化疗后CGRP含量比化疗前显著降低(P＜0.01),结直肠癌患者血浆CGRP化疗后比化疗前明显降低(P＜0.05),原发性肝癌、结直肠癌患者血浆CGRP化疗前后比较差异有统计学意义,胃癌及其他癌症化疗前后比较差异无统计学意义(P＞0.05).结论 化学治疗前后血浆MTL和CGRP含量检测对判断消化道肿瘤的治疗效果可能有所帮助。
Test configuration method based on E-dominant NSGA2

Field: Computer Science (Physical Sciences)

Abstract In order to solve the problems of the same target importance and too large solution set in the existing solutions, an E-dominant NSGA2 algorithm is proposed to solve the problem. In this paper, the mathematical model of the problem is established with the optimization objectives of test cost, test quantity and false alarm rate. The testability model under unreliable test condition is established by using Bayesian network. Then the E-dominated NSGA2 algorithm is used to solve the problem. After verification, the algorithm has good performance and practical value.
2206-LB: Weight Conversations—Examining Clinicians' Approaches to Discussing Weight during Routine Diabetes Care

Field: Health Professions (Health Sciences)

Introduction and Objective: Weight management is an essential part of diabetes care, but discussing weight and weight loss in the office remains a challenge. To determine how clinicians approach this potentially stigmatizing topic during routine primary care, we analyzed videorecorded clinical encounters from a randomized trial comparing usual care with and without an agenda setting intervention (QBSAFE, NCT05553912). Methods: Using an ad hoc codebook, two researchers reviewed and independently coded recordings of primary care visits with eligible adults living with type 2 diabetes (HbA1c at least 8%, fluency in English or Spanish, and BMI at least 25 kg/m2). The codebook noted whether the patient or clinician initiated the weight-related conversation, words used to describe weight, and any interventions recommended. Chi-square tests assessed the statistical significance of relationships between variables. Results: Investigators coded 123 clinical encounters with 47 men and 76 women aged 34 to 80, with BMI between 25 and 52 kg/m2 and HbA1c between 8.2 and 18%. Weight was discussed in 48 encounters (39%), with clinicians initiating the conversation in 27 of these (56%). Clinicians frequently recommended dietary changes (n=21, 44%) and diabetes medications associated with weight loss (n=25, 52%). Bariatric surgery was not discussed. Of note, weight was significantly more likely to be discussed with patients on GLP-1 receptor agonists (p=0.04). Clinicians avoided the terms “overweight” and “obesity” altogether, favoring a discussion of “weight.” Conclusion: Weight conversations occurred in less than half of these routine encounters, focused mostly on medication use and lifestyle changes, and avoided potentially stigmatizing language. While the use of less stigmatizing language appears to be improving the quality of these encounters, additional studies are needed to define interventions that will increase the frequency of weight conversations in diabetes care. Disclosure J.A. Dower: None. C. Gonzalez Lopez: None. M.E. Branda: None. A.W. Camp: None. A.S. Chen: None. V.M. Montori: None. M. Ochoa-Prieto: None. K.J. Lipska: None. Funding NIH (1R01DK129616-01A1)
5 Qualities the Best People in the GOLDEN DIAMOND ESCORTS Industry Tend to Have

Field: Social Sciences (Social Sciences)

Here&rsquo;s my basic definition of an escort: it&rsquo;s anyone who runs their own business, offering hands-on sexy services in exchange for payment. A date with an escort often closely resembles a real-life date: you might go out to dinner together, talk for hours, and spend time getting to know each other. Or, like a good hook up, you might jump straight into bed together and discover some sizzling sexual chemistry.
Development of a Neopentyl 211At‐Labeled Activated Ester Providing In Vivo Stable 211At‐Labeled Antibodies for Targeted Alpha Therapy

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract In this study we developed a neopentyl 211 At‐labeled activated ester that incorporates a triazole spacer and applied it to the synthesis of an 211 At‐labeled cetuximab. The activated ester was synthesized via the nucleophilic 211 At‐astatination of a neopentyl sulfonate carrying two long alkyl chains that serve as a lipid tag, which was followed by the hydrolysis of an acetal. Additionally, we developed a novel Resin‐Assisted Purification and Deprotection (RAPD) protocol involving a solid‐phase extraction of the protected 211 At‐labeled compound from the mixture of the labeling reaction, hydrolysis of the acetal on the resin, and finally an elution of the 211 At‐labeled activator from the resin. This method allows the synthesis of an 211 At‐labeled activated ester with high purity through a simplified procedure that circumvents the need for HPLC purification. Using this 211 At‐labeled activated ester, we efficiently synthesized 211 At‐labeled cetuximab in 27±1 % radiochemical yield with 95 % radiochemical purity. This 211 At‐activated ester demonstrated high reactivity, and enabled the completion of the reaction with the antibody within 10 min. In comparative biodistribution studies between 211 At‐labeled cetuximab and the corresponding 125 I‐labeled cetuximab in normal mice, both the thyroid and stomach showed radioactivity levels that were less than 1.0 % of the injected dose.
Academic dishonesty, personality traits and academic adjustment

Field: Psychology (Social Sciences)

Many recent studies has been indicating that academic \ndishonesty is more frequent in higher education, under the form plagiarism, \ncheating on exams, and copying assignments from other students. The present research aims to explore the relationship of personality traits, academic dishonesty and academic adjustment. The results showed that conscientiousness, honesty and openness were significantly negatively related to reports of academic dishonesty. Academic neuroticism was the most powerful predictor of cheating behaviours, while an overall high level of maladjustment predicted the positive attitudes towards academic cheating. The significant associations between academic adjustment and academic dishonesty confirmed previous research in the field.
Case 2: Prolonged Hypoglycemia in an Adolescent without Diabetes

Field: Medicine (Health Sciences)

1. Akshay Sharma, MBBS*
2. Irene Hong-McAtee, MD†

1. *St Jude Children's Research Hospital, Memphis, TN.

2. †Division of Endocrinology and Diabetes, Vanderbilt University School of Medicine, Nashville, TN.

A 16-year-old girl who has no contributory past medical history suddenly starts experiencing generalized weakness and drowsiness. In the emergency department, her finger stick blood glucose (BG) is 22 mg/dL (1.2 mmol/L) (fasting reference range 70–99 mg/dL [3.9–5.5 mmol/L]). She is given 160 mL of 12.5% dextrose intravenously (IV) and is admitted to the pediatric intensive care unit (PICU) for monitoring and further management.

On arrival to the PICU, her vital signs show sinus tachycardia (heart rate of 118 beats per minute). Her weight is 38.9 kg and height is 144.7 cm (both below the 3rd percentile). Her physical examination findings are otherwise unremarkable.

Her basic metabolic profile and complete blood cell count do not reveal any abnormalities except a low BG. Blood is collected to measure serum insulin, C-peptide, proinsulin, β-hydroxybutyric acid, and ketones when her BG concentration decreases to less than 50 mg/dL (2.8 mmol/L) in the PICU.

She is given 12.5% dextrose multiple times as well as a glucagon injection once for BG less than 50 mg/dL (2.8 mmol/L) (Figure). Strikingly, she does not display any other symptoms until her BG decreases to less than 20 mg/dL (1.1 mmol/L). At one point her BG reaches 12 mg/dL (0.7 mmol/L) and she develops diaphoresis but she still remains conversational. Her urine drug screen is negative for any oral hypoglycemic agents. Corticotropin and glucagon stimulation tests as well as …
Leaf and stem chemical composition of divergent alfalfa cultivars

Field: Agricultural and Biological Sciences (Life Sciences)

Alfalfa is a perennial crop that provides a higher yield of proteins per unit area than any field crop, which makes it highly desirable for the production of hay and feed for domestic animals (especially ruminants). The objective of this study was to determine the dry matter chemical composition in the whole plant, leaves and stems of five divergent alfalfa cultivars. Variations were found in the contents of proteins, hemicellulose, NDF, ADF, ADL, cellulose, and minerals depending on genotype and plant part. Significant differences existed between the cultivars in quality parameters, indicating that breeding for high alfalfa quality is justifiable.
Accurate and traceable measurement of nano- and microstructures

Field: Engineering (Physical Sciences)

An approach to establishing rigorous nano- and microdimensional metrology using scanning probe microscopes (SPMs) and metrological profilometers is presented. An overview on calibrations of nanostructures—such as step height, one- and two-dimensional gratings, feature width, nanoroughness and geometry of a nanohardness indenter—and microstructures—such as microgroove, microroughness and geometry of a macrohardness indenter—is given in this paper.
A Multistate Transition Model for Analyzing Diseases in Elderly Population

Field: Medicine (Health Sciences)

Abstract: In this study, a competing risk model is proposed to analyze the transitions to diseases among elderly people employing the proportional hazards model. This study provides important findings regarding the disease pattern among the elderly people and the factors associated with such transitions. The Health and Retirement Study data are considered for the period of 1992-2000. The major diseases or complications considered in this study are stroke, lung diseases, diabetes mellitus, blood pressure and arthritis. The transitions to different diseases or complications are explained by selected covariates such as gender, race, marital status, smoking, drinking, physical exercise and BMI. The results indicate that gender, race, smoking and BMI are significantly associated with transitions to different diseases or complications. The results are displayed for transitions to each disease or complication separately for competing risk framework as well as for the combined transition to any of the selected diseases or complications. This paper reveals some important health issues related to the transitions to the selected diseases or complications among the elderly people and the factors associated with such transitions are identified.
Migrations, daily mobility, local identity, housing projects in Italy: A biographical approach

Field: Social Sciences (Social Sciences)

Abstract Starting from the description of sample surveys and research on spatial mobility (migration and daily mobility) and on other dimensions strictly connected with this topic (local identity and housing projects) organized and conducted by the University of Pisa over the last fifteen years, this article presents an extensive and in-depth overview of methods that can to be used for analysing this type of statistical information and the type of results that can be achieved, with particular focus on the biographical approach.
Análisis y mejora del proceso de formación de la carrera de ingeniería industrial de la Universidad Técnica de Manabí y su influencia en la acreditación

Field: Social Sciences (Social Sciences)

Abstract— The paper presents an analysis related to the results of self-evaluation of careers in higher education, highlighting the particularities in the career of industrial engineering at the Technical University of Manabí. an analysis related to the results of a profiled to identify weaknesses in the quality of training of students, which developed in the Industrial Engineering of higher learning and an improvement plan is presented research is available to achieve obtain the quality demanded by the CEAACES (Council of evaluation and quality Assurance in Higher Education to achieve accreditation. Index Terms— accreditation career, self-assessment, training processes, improvement plan
Pachybrachis huachuca Barney 2021

Field: Agricultural and Biological Sciences (Life Sciences)

5. Pachybrachis huachuca Barney, 2021 Pachybrachis huachuca Barney 2021b: 22. Remarks. Barney (2019b) described P. huachuca based on a pair of beetles from Sunnyside Canyon, Arizona. Refer to Barney (2019b) for a species description, figures, specimens examined, and distribution map. No additional specimens were examined.
Chemical Exposure and Effects in Freshwater Aquatic Species

Field: Environmental Science (Physical Sciences)

To protect aquatic ecosystems from stresses induced by toxic chemicals, risk models must be developed, calibrated and verified for feral populations. Although risk models require good estimates of chemical exposure (dose) and quantitative measures of effects (response), few models, if any, have been appropriately calibrated for linking dose and response in situ. It is this lack of knowledge that limits the development of strong cause-effect relationships for aquatic species.Exposure models, using quantitative biomonitoring techniques, have been developed independently from bioassay and/or biomarker systems that are used to quantify stress. The present research integrated these two approaches by comprehensively calibrating the brown bullhead (Ameiurus nebulosus) as an appropriate bioindicator of toxicological stress in aquatic ecosystems. This was achieved by integrating quantitative biomonitoring techniques with a novel, sensitive assay for genotoxicity of polynuclear aromatic hydrocarbons (PAHs).At four sites along the river, chemical exposures and the incidence of dermal papillomas and neoplastic lesions in liver tissue were quantified, along with the measurement of PAH metabolites in bile, quantification of DNA damage in erythrocytes using the alkaline single cell gel electrophoresis (Comet assay), and the quantification of changes in apoptotic processes in dermal and liver tissues of exposed fish. Field studies on metabolite formation and apoptosis were compared to laboratory investigations in order to quantify the link between PAH metabolites and genotoxicity. Bullheads were exposed to Detroit River bottom sediment and environmentally-relevant levels of a major genotoxic PAH, benzo[a]pyrene (B[a]P), and dose-response models of metabolite formation were developed in order to determine the mass of PAH chemicals that are converted to DNA active metabolites. Genotoxicity was assessed in these laboratory populations using the comet assay on erythrocytes and liver cells. We assessed the link between DNA damage and the down-regulation of apoptosis, which is characterized as one of the key initial steps of tumorogenesis.This title belongs to WERF Research Report SeriesISBN: 9781843397540 (Print)ISBN: 9781780403922 (eBook)
The Potential of Ornamental Fish Culture in Biofloc Technology with Different C/N Ratio and Multi-Criteria Decision Making Model: An Example of Goldfish (Carassius auratus)

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract

Biofloc technology (BFT) has become an agenda not only to meet the need for protein food but also for ornamental aquaculture with the increasing interest in sustainable aquaculture. In this context, the current study focused on BFT for ornamental goldfish (Carassius auratus), which has commercial value. In the study conducted with control and two different C/N ratios (15:1 and 20:1), nitrogen cycle occurred rapidly in BFT groups. On the other hand, increasing the C/N ratio had a positive effect on total suspended solids and total bacteria count in the culture water. In terms of growth performance, specific growth rate and weight gain were observed to be significantly higher at high C/N ratio. Feed conversion ratio showed lower results for the C/N 20 group. According to the liver histological results, the vacuolization symptom is more severe in BFT groups. Considering all the results, the suitability of C. auratuscultivation in the BFT system with a C/N ratio of 20 was proven according to nine different evaluation criteria. In conclusion, the cultivation of C. auratus in BFT systems is recommended both economically and ecologically.
Chronic appendicitis diagnosed incidentally by colonoscopy

Field: Medicine (Health Sciences)

A57-year-old woman attended the endoscopy unit for a colonoscopy for polyp surveillance. For the previous 2 weeks she reported experiencing intermittent pain in her lower right abdomen without any systemic upset. On examination she was apyrexial with a soft, nontender abdomen. Colonoscopy revealed diverticular disease affecting the entire colon and a 3 mm tubular adenoma in the transverse colon. The caecum appeared normal but the appendiceal orifice was found to be oedematous and inflamed (Figure 1). No pus could be seen emerging from the appendiceal orifice. Given that the patient was systemically well with no abdominal tenderness it was thought she may have a low-grade appendicitis and allowed home with a 7-day course of metronidazole.
Double-heavy tetraquark states with heavy diquark-antiquark symmetry *

Field: Physics and Astronomy (Physical Sciences)

Abstract We calculate the masses of the ( ; ) tetraquark states with the aid of heavy diquark-antiquark symmetry (HDAS) and the chromomagnetic interaction (CMI) model. The masses of the highest-spin ( ) tetraquarks that have only the color structure are related with those of conventional hadrons using HDAS. Thereafter, the masses of their partner states are determined with the mass splittings in the CMI model. Our numerical results reveal that (i) the lightest ( ) is an state around 3929 MeV (53 MeV above the threshold), and none of the double-charm tetraquarks are stable; (ii) the stable double-bottom tetraquarks are the lowest around 10488 MeV ( MeV below the threshold) and the lowest around 10671 MeV ( MeV below the threshold); and (iii) the two lowest tetraquarks, namely the lowest around 7167 MeV and the lowest around 7223 MeV, are in the near-threshold states. Moreover, we discuss the constraints on the masses of double-heavy hadrons. Specifically, for the lowest nonstrange tetraquarks, we obtain MeV, MeV, and MeV.
Effect of salinity on the nutrient uptake in sorghum at seedling stage

Field: Agricultural and Biological Sciences (Life Sciences)

Nine of the 20 varieties tested were tolerant of NaCl at 1000-5000 p.p.m. The two susceptible varieties had a lower sodium, potassium and magnesium content than the tolerant varieties. The calcium and magnesium content of the tolerant varieties increased up to 4000 p.p.m. NaCl, while the potassium content decreased. The tolerant varieties had a lower chloride content than the susceptible varieties
Prodromal Signs and Symptoms of Chronic Pancreatitis

Field: Medicine (Health Sciences)

Goal: We aimed to extract the percent of signs and symptoms at the time of diagnosis from published studies and to pool these using meta-analytic techniques. Background: Delayed or misdiagnosis of chronic pancreatitis may occur because the signs and symptoms are nonspecific and varied. Study: We performed a systematic review of studies reporting the signs and symptoms of chronic pancreatitis at diagnosis. The percentage of patients with each sign and symptom was extracted and random-effects meta-analyses used to calculate pooled percentages. Results: In total, 22 observational studies were included. Across 14 studies, 55% of chronic pancreatitis patients were classified as having alcoholic etiology. Abdominal pain was the most common symptom (76%), and weight loss was reported in 22% of patients. Jaundice occurred in 11% of patients and steatorrhoea in 3%. Half of the patients had a history of acute pancreatitis, and 28% had diabetes mellitus at diagnosis. Heterogeneity between the studies was high for all signs and symptoms. Conclusions: This research has identified some common features of patients with chronic pancreatitis, but the high heterogeneity makes it difficult to draw solid conclusions. Carefully designed studies to examine the signs and symptoms leading up to a diagnosis of chronic pancreatitis, and common combinations, are required. These would enable the development of a tool to aid in the early identification of chronic pancreatitis in the primary care setting, with potential for improved short-term and long-term outcomes for patients.
Oligonucleotide-Directed Assembly of Materials:  Defined Oligomers

Field: Chemistry (Physical Sciences)

A nano-architectural system that has high variability while maintaining component specificity is described. Tetraphenylcyclobutadiene(cyclopentadienyl)cobalt complexes and phenyleneethynylene trimers were synthesized and subsequently modified with oligonucleotides utilizing standard phosphoramidite chemistry. The resulting oligonucleotide modified organics (OMOs) were characterized by UV-vis spectroscopy, fluorescence spectroscopy, and phosphate analysis. Hybridization of these OMOs resulted in a series of self-assembled oligomeric hybrids of varying length and topology. These hybrids were characterized by melting temperature, polyacrylamide gel electrophoresis, and fluorescence spectroscopy. This model system demonstrates the power of DNA to self-assemble modules of interest-independent of the module itself.
Combination Preemptive Peripheral Nerve Block in Limb Surgery. A Prospective Study

Field: Medicine (Health Sciences)

Background and objectives: Patients often suffer from moderate to severe pain during the early recovery period in orthopedic surgery. We investigated the impact of a single-shot preoperative peripheral nerve block (PNB) on post-anesthesia recovery parameters and interleukin (IL)-6 level during limb surgery. Materials and Methods: A prospective randomized controlled study was conducted, and patients scheduled for limb surgery were recruited. Sixty patients were randomly assigned to either the PNB group or control group, who received morphine as a primary analgesic. The peak verbal numeric rating scale (NRS) score in the post-anesthesia care unit (PACU) was evaluated as a primary outcome. We also recorded rescue analgesics requirement and wake-up time from anesthesia in the PACU. In addition, the change of plasma IL-6 level after incision was measured. Results: Fifty-two patients completed the study, 27 and 25 cases in the PNB and control group, respectively. Preemptive PNB significantly reduced peak NRS score in the PACU compared to control group. Lower rescue analgesics requirement and rapid wake-up from anesthesia were also noted in PNB group. The IL-6 concentration increased less in the PNB group at 2 h after incision. Conclusions: Preemptive PNB attenuates IL-6 expression 2 h after incision and improves pain management in the PACU. PNB was considered as an essential part of pain management in limb surgery.