jimnoneill/paper-to-field-training huggingface dataset:
Novel metal-based photosensitizers for photodynamic therapy: exploratory study (Conference Presentation)

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Ruthenium and osmium-based photosensitizers (PS) are compounds of interest for use in photodynamic therapy (PDT). These PS's can be activated by light wavelengths in the range of 400-675 nm, which can be selected based on the tumor environment, treatment area, and available light sources. The objective of this study was to explore these PS's for the treatment of several relatively aggressive cancer cell lines. A human adenocarcinoma cell line (A549) was treated with ruthenium-based compounds at concentrations of 1, 5, or 10 uM, followed by light treatment of 93 J/cm2 at either 532 nm or 630 nm. Similarly, osmium-based compounds were used to treat A549, murine melanoma (B16F10) and squamous cell carcinoma (SCCVII) cell lines at concentrations of 0.05, 1, or 3 uM, followed by light treatment of 93 J/cm2 at 630 nm. Cells survival was assessed 24 hours after PDT treatment using either alamarBlue or MTT cell viability assays. In-vitro MTT viability assays revealed that ruthenium-based compounds activated with 630 nm light showed high SCCVII cell toxicity at 5uM. AlamarBlue assays have shown that ruthenium based compounds activated by 532 nm light show high A549 cell toxicity at 1uM in-vitro. Osmium-based compounds showed optimal PDT-mediated cytotoxicity in SCCVII, A549, and B16F10 cell lines at a concentration of 1uM activated by 630 nm light, while exhibiting minimal dark toxicity. The Ruthenium and Osmium-based compounds are potentially potent PSs against lung, melanoma and squamous cell carcinoma cells, in-vitro.
Rapid Identification of Single Nucleotide Substitutions Using SeqDoC

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Identification and characterization of nucleotide substitutions in DNA sequences for single nucleotide polymorphism or point mutation detection can be a time consuming and sometimes inaccurate process, particularly in relatively low-throughput situations where fully automated solutions may not be appropriate. SeqDoC provides a simple web-based application to simplify this identification process, by using direct subtractive comparison of the raw sequence traces to highlight differences characteristic of nucleotide substitutions. Sequencing artefacts, such as variable peak separation and signal strength, are compensated for with moving window normalisation functions, whereas the signal to noise ratio of the comparison trace is greatly enhanced by applying an algorithm to emphasise features associated with nucleotide substitutions. Analysis of the output is simple and intuitive, permitting rapid identification of points of difference between the reference and test sequence traces.
ONSETS: AN ELEMENT OF ECOLOGICAL SOUND INTERPRETATION

Field: Neuroscience (Life Sciences)

We justify the usage of onsets in sound processing by appealing to an ecological view of auditory processing. The biological basis for onset processing is briefly discussed, and we describe our biologically motivated approach for a spike-based system for onset detection. This is based on a auditory-nerve like representation (with multiple spike trains per filter-bank band) followed by a leaky integrateand-fire neuron with depressing synapses. Onsets are detected with essentially zero latency relative to the filter-bank. We show how this can be used to find the starts of certain phonemes in the TIMIT database, and how, by a small variation in the parameters, it can be used to detect amplitude modulation.
Effect of drag reducing riblet surface on coherent structure in turbulent boundary layer

Field: Engineering (Physical Sciences)

<p>The characteristics of turbulent boundary layer over streamwise aligned drag reducing riblet surface under zero-pressure gradient are investigated using particle image velocimetry. The formation and distribution of large-scale coherent structures and their effect on momentum partition are analyzed using two-point correlation and probability density function. Compared with smooth surface, the streamwise riblets reduce the friction velocity and Reynolds stress in the turbulent boundary layer, indicating the drag reduction effect. Strong correlation has been found between the occurrence of hairpin vortices and the momentum distribution. The number and streamwise length scale of hairpin vortices decrease over streamwise riblet surface. The correlation between number of uniform momentum zones and Reynolds number remains the same as smooth surface.</p>
Serratia odorifera a Midgut Inhabitant of Aedes aegypti Mosquito Enhances Its Susceptibility to Dengue-2 Virus

Field: Immunology and Microbiology (Life Sciences)

Mosquito midgut plays a crucial role in its vector susceptibility and pathogen interaction. Identification of the sustainable microflora of the midgut environment can therefore help in evaluating its contribution in mosquito-pathogen interaction and in turn vector competence. To understand the bacterial diversity in the midgut of Aedes aegypti mosquitoes, we conducted a screening study of the gut microbes of these mosquitoes which were either collected from fields or reared in the laboratory ‘‘culture-dependent’ ’ approach. This work demonstrated that the microbial flora of larvae and adult Ae. aegypti midgut is complex and is dominated by Gram negative proteobacteria. Serratia odorifera was found to be stably associated in the midguts of field collected and laboratory reared larvae and adult females. The potential influence of this sustainable gut microbe on DENV-2 susceptibility of this vector was evaluated by co-feeding S. odorifera with DENV-2 to adult Ae. aegypti females (free of gut flora). The observations revealed that the viral susceptibility of these Aedes females enhanced significantly as compared to solely dengue-2 fed and another gut inhabitant, Microbacterium oxydans co-fed females. Based on the results of this study we proposed that the enhancement in the DENV-2 susceptibility of Ae. aegypti females was due to blocking of prohibitin molecule present on the midgut surface of these females by the polypeptide of
The association of adiposity with kidney function decline among HIV‐infected adults: findings from the Fat Redistribution and Metabolic Changes in HIV Infection (FRAM) study

Field: Medicine (Health Sciences)

Objectives The aim of the study was to investigate the association of adiposity with longitudinal kidney function change in 544 HIV ‐infected persons in the S tudy of F at R edistribution and M etabolic C hange in HIV infection ( FRAM ) cohort over 5 years of follow‐up. Methods The regional distribution of muscle and adipose tissue was quantified by whole‐body magnetic resonance imaging ( MRI ), and total adiponectin and leptin levels were measured in serum. Kidney function was assessed using the estimated glomerular filtration rate from serum cystatin C (e GFRC ys), obtained at baseline and follow‐up. Rapid kidney function decline was defined as annual loss of e GFRC ys ≥ 3 mL/min/1.73 m 2 , and incident chronic kidney disease ( CKD ) was defined as e GFRC ys < 60 mL/min/1.73 m 2 . Multivariate regression analysis was adjusted for age, race, gender, glucose, antihypertensive use, serum albumin, baseline and change in HIV viral load. Results At baseline, mean age was 43 years, mean e GFRC ys was 86 mL/min/1.73 m 2 , and 21% of patients had albuminuria. The mean (± standard deviation) e GFRC ys decline was −0.11 ± 4.87 mL/min/1.73 m 2 per year; 23% of participants had rapid kidney function decline, and 10% developed incident CKD . The lowest tertile of visceral adipose tissue and the highest tertile of adiponectin were both marginally associated with annual kidney function decline of −0.5 mL/min/1.73 m 2 each, but these associations were not statistically significant after adjustment. We found no statistically significant associations of MRI ‐measured regional adiposity or serum adipokines with rapid kidney function decline or incident CKD (all P ‐values > 0.1 in adjusted models). Conclusions Contrary to findings in the general population, adiposity did not have a substantial association with longitudinal change in kidney function among HIV ‐infected persons.
Pediatric herpes simplex virus infections: an evidence-based approach to treatment.

Field: Medicine (Health Sciences)

Herpes simplex virus is a common virus that causes a variety of clinical presentations ranging from mild to life-threatening. Orolabial and genital herpes are common disorders that can often be managed in an outpatient setting; however, some patients do present to the emergency department with those conditions, and emergency clinicians should be aware of possible complications in the pediatric population. Neonatal herpes is a rare disorder, but prompt recognition and initiation of antiviral therapy is imperative, as the morbidity and mortality of the disease is high. Herpes encephalitis is an emergency that also requires a high index of suspicion to diagnose. Herpes simplex virus is also responsible for a variety of other clinical presentations, including herpes gladiatorum, herpetic whitlow, eczema herpeticum, and ocular herpes. This issue reviews the common clinical presentations of the herpes simplex virus, the life-threatening infections that require expedient identification and management, and recommended treatment regimens.
Measuring The Relationship Between Customer Satisfaction, Service Quality and Corporate Image: A Case Study of Airtel and BSNL

Field: Business, Management and Accounting (Social Sciences)

In the light of the changes taking place in the business world as a result of globalization, liberalization, and increasing competition nocompany can afford to ignore the importance of favourable (corporate) image since it reflects the character of a company. The morefavourable is the image, the more active people are in recommending a company’s products to their friends and relatives. The mainpurpose of the above study is to measure the relationship between service quality, customer satisfaction, and corporate image. A samplesize of 1000 customers has been taken in the study comprising of 500 Airtel and BSNL users each. The analysis indicates that both thevariables customer satisfaction and service quality have been found to be significant predictors of the corporate image of the telecomcompanies.
Are some cases of spina bifida combined with cerebral palsy? A study of 28 cases

Field: Medicine (Health Sciences)

AIM: This study is a description of a group of children with spina bifida who present with neurological impairments resembling cerebral palsy. Spina bifida is a complex congenital spinal anomaly causing paraparesis. Some children with spina bifida have neurological impairments, which fit into the definition of cerebral palsy. Extensive spasticity discordant with the level of the spina bifida lesion, upper extremity dysfunction and cognitive impairment are suggestive of concomitant cerebral palsy in these cases. The probable etiology for this problem may be neglected hydrocephalus, meningitis or other brain lesions common in spina bifida. METHODS: In this study we have reviewed our cohort of 365 patients and found 28 cases with the above-mentioned findings. Main evaluation parameters used were the Ashworth scale for spasticity, Green and Banks modified classification for hand function, cognitive function, mental status, ambulation and lesion level. RESULTS: Twenty-eight out of 365 children with spina bifida had neurological impairments resembling cerebral palsy. Their mean age was 59.9+/-41.3 (range, 16.8-31.2) months. Seventy percent of the patients were nonambulatory and therapeutic ambulation only was present in 30% of patients. Seventy percent of the children had spasticity of Ashworth grade 2 or higher. Upper extremity dysfunction, and cognitive impairment were also observed in 80% of the patients involved in this study. The spinal lesion was 60% thoracal and 20% upper lumbar, and none of the cases had signs of spinal tethering. CONCLUSIONS: We believe that this group of children with spina bifida may be regarded as having concomitant cerebral palsy. This fact implies that the management of this group of patients having mixed findings must be changed accordingly.
Pengaruh Latihan Combination Play terhadap Kolektivitas Tim Futsal Putra UNJ

Field: Social Sciences (Social Sciences)

In this problem, the State University futsal team The Jakarta State University futsal team has a problem of lack of success in attacking and controlling the ball through the application of ineffective combination play, which hinders the ability of the Jakarta State University team to create space to become opportunities and create goals. One of the problems that may arise is the lack of variety in the combination play of players when attacking and controlling the ball. The research method used in this research is the experimental method. The variables studied, including the independent variable and the dependent variable, have been determined explicitly by the researcher since the beginning of the study. The independent variable in this study is combination play training, while the dependent variable is collectivity. The results showed that there was an increase in collectivity ability after being given combination play training with a tcount value of 6.23 which is greater than ttable 2.16 with a significance level of 0.05. This is in accordance with the framework and theory as well as the research hypothesis which says that there is an effect of combination play training on futsal collectivity. Based on the problems found, which are supported by literature review, framework and research results, it can be concluded that there is an effect of combination play training on the collectivity of the UNJ futsal team.
Spatio-Temporal Variation of Drought Characteristics in Bearma Basin of Bundelkhand Region in Madhya Pradesh

Field: Environmental Science (Physical Sciences)

Long-term drought forecasts can provide valuable information to help in mitigation of the consequences of drought. The study has been carried out for Bearma basin of Bundelkhand region in Madhya Pradesh which is regularly suffered from frequent droughts due to large variation of rainfall. Rainfall data of 5 stations located in Bearma basin over the period of 1976–2005 were used. Efforts have been made to identify the drought characteristics through the modern technique using the Standardized Precipitation Index (SPI). The drought severities as well as the drought intensity have been evaluated for all the rain gauge stations in Bearma basin. The result showed that Damoh faced drought of 5 months in 1979 with the highest drought severity of -11.95 and intensity of -2.39 whereas a drought of severity -11.12 occurred during June to November 1979 at Jabera for a period of 6 months. It is also indicated that the maximum intensity of -5.50 was observed between onset and termination of drought of 1984 at Hatta. The drought of 4 months duration was recorded at Deori during June-September 1992 and at Rehli during August-November 1986. The spatial and temporal variations of drought and its progression into more areas in subsequent months and its withdrawal after the initiation of sufficient rainfall has been studied in detail for drought year 2002 as well as normal year 2004. The analysis indicated that each drought had unique phenomenon and area under its influence varied from one drought event to the other. In July 2002, 100% of the basin was reeling under extreme and severe drought whereas by October 2002, over 71% of the basin area was back to normal condition due to favourable rainfall scenario. During 2004, the drought situation varied rapidly between successive months. About 86% of the area was affected with moderate drought in June 2004 but in July and August, the situation was near normal in the entire basin.
Optimal Order Pick-and-Place of Objects in Cluttered Scene by a Mobile Manipulator

Field: Computer Science (Physical Sciences)

In this letter, we present a fast method for autonomously planing manipulation tasks for mobile manipulators. The planner defines an optimal order to perform pick-and-place operations for taking objects from a cluttered scene to specific deposit areas considering both, manipulator and mobile base motion. Our method first examines the grasping feasibility of the objects with an inverse reachability map. Then, it defines all the placing locations for the objects and analyses the corresponding preconditions to reach them. Finally, it defines a sequence for rearranging the objects that minimize the execution time. We take advantage of the environment's underlying combinatorial structure to define the shortest path. In this work, we consider both the monotone case, where each object may be moved at most once, and the non-monotone cases. An experimental evaluation on the Human Support Robot (HSR) shows the effectiveness of our solutions and the scalability of our method as the number of objects increases for both cases. Tests on monotone problem instances with 20 objects show the proposed method can save up to 17% base traveling time when comparing to baseline methods at the cost of less than 9 seconds planning time. In a test on a simple non-monotone instance, the proposed method further reduces the total execution time by 25% by minimizing the total number of actions in a few seconds of planning time. The characteristic speed in re-planning makes our method suitable for online usage.
Important Changes in the ACLS 2000 Guidelines for the Management of Cardiac Arrest

Field: Health Professions (Health Sciences)

This feature examines the impact of pharmacologic interventions on the treatment of the critically ill patient—an area of health care that has become increasingly complex. It will review recent advances (including evolving and controversial data) in drug therapy for adult ICU patients and assess these new modalities in terms of clinical, humanistic, and economic outcomes.
Midterm Elections’ Stock Market Surge: An Unintentional Gift from US Politicians

Field: Economics, Econometrics and Finance (Social Sciences)

Our article offers a scholarly scrutiny \nof the midterm election effect on the U.S. \nequity market. We first examine whether any \npattern is present in the U.S. stock returns \nafter the midterm elections and then carefully \ndocument the magnitude of it. Second, we \ncompare the post-election stock market \ncycles for the presidential and the midterm \nelections. Finally, we examine whether fiscal \nor monetary policies are solely causing the \ndistinctive return pattern.
Sports tourism consumer motivation

Field: Social Sciences (Social Sciences)

Summary “Sport has a special role in contemporary society that goes well beyond mere entertainment” [Kahle — p. 51] The connection between the person, be he or she a participant, a spectator or organizational worker are quite unique to sproting activities. Sports tourists travel for many reasons. In sports tourism, satisfaction of needs is found within five distinct activity categories — events, tours, resorts, attractions and cruises. Travel decisions are made not only for extrinsic motives suc as temporary escapism, feelings, desire for involvement but also for extrinsic reasons — rewards, recognition, prestige. The “weight” given to each or combined motive, either positive or negative, influences the basic motivational interplay to be found within the sports travel dynamics. Further, intrinsic influences affecting the decisions making process could be chanagable and marginal factors dealing with health condition, discretionary monies, age demographics and the like. There also is a distinction between “intangibility” of services that cannot be sensed, felt or touched and the non‐standardizaation of services that fluctuate with consumer demands, requirements and expectations. [Taylor — p. 92] The former intangible services are difficult to evaluate; the latter are quite tangible. Furthermore, travel distances to familiar or unfamiliar destinations are overriding and respectfully conducive to meaning, interest and drives. The preceding model illustrates the motivational interplay found in sports travellers decision making process. The “perponderance” and the complexity of motives, incentives and reasons viewed by the sports tourist hang in the balance of ACTION and INACTION.
Study of translation initiation factors eIF5B and eIF3

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Translation initiation plays a central role in every living organism. Studying the proteins helping the ribosome toward this task, Initiation Factors (Ifs), allows to get insights into the complex molecular mechanisms ensuring a high fidelity and efficiency of translation initiation. When comparing the existing initiation factors in the three kingdoms of life, three universally conserved initiation factors were identified. Among these, the eukaryotic/archaeal factor e/aIF5B, the counterpart of the bacterial factor IF2, stimulates the ribosomal subunits joining step as in Bacteria. However, the universality of this factor was limited by the lack of reported interaction between the factor e/aIF5B and the initiator tRNA whereas such an interaction was characterized in Bacteria. A first part of this thesis work aimed at extending the functional similarity between the factors by bringing to light a binding of methionylated initiator tRNA by the factor e/aIF5B. The characteristics of this binding are very similar to the binding of formylated methionylated initiator tRNA by the bacterial factor IF2. A second part of my thesis work dealt with the factor eIF3, the most complex factor of the eukaryotic translation initiation apparatus. This multimeric factor, composed of 13 subunits in human and 5 in budding yeast, has no counterpart in the other kingdoms of life despite a central and essential role in Eukaryotes. In addition, eIF3 is involved in numerous cancers. However, the understanding of its functions is severely limited by the lack of structural information on subunits interactions and on interactions with other partners of the translation apparatus. This work led to the development of a plasmid library allowing the coexpression of Saccharomyces cerevisiae eIF3's subunits or stabilized forms of them in the Bacteria Escherichia coli. The purifications of the individual subunits and different subcomplexes are leading us on the road of the factor structure determination by an approach combining crystallography and electron microscopy.
SARCOMA OF EYELID

Field: Medicine (Health Sciences)

In 1927, Stanowsky 1 collected sixty-five cases from the literature of sarcoma of the eyelid and reported two more cases. Additional cases were reported by Juler, 2 Stock, 3 Rifaat (three cases), 4 Fiore, 5 Nichelatti, 6 Gabrielides, 7 Jaensch (three cases), 8 DeLogu, 9 Ishibashi 10 and Vele (three cases). 11 The ages of the patients varied from a few months to 80 years. The distribution according to sex was approximately equal. In the preponderance of cases the upper eyelid was involved. Many of the tumors when first seen were mistaken for chalazions, and their true nature was recognized later. The type of cell varied, round, spindle and mixed types being reported. Some of the tumors contained melanotic pigment. Some were excised without recurrence, and a few disappeared after irradiation. Some showed local recurrence ; some showed metastases, and several showed extension to regional lymph nodes. Many extended beyond