jimnoneill/paper-to-field-training huggingface dataset:
Human immune globulin 10% with recombinant human Hyaluronidase- A Review

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Primary immunodeficiency disorder (PID) refers to a heterogeneous cluster of over 350 syndromes that upshot from defects in the immune system development or function. PIDs are broadly classified as disorders of adaptive immunity or innate immunity. The enhanced efficacy of human immune serum globulin 10% with recombinant human Hyaluronidase with comparison to blood vessel human gamma globulin is a very prospective open-label study for PID. Treatment of primary immunological disorder diseases (PIDD) with Subcutaneous(SC) infusions of immune gamma globulin headed by an injection of hyazyme to extend SC tissue porousness was evaluated in two consecutive, prospective, non-controlled, multi-center studies. HYQVIA could be a subcutaneously mediated medication to treat the primary immunological disorder in adults. ENHANZE® drug delivery technology relies on the proprietary rHuPH20 macromolecule that facilitates the SC delivery of co administered medical specialty. Recombinant Human Hyaluronidase works by degrading the glycosaminoglycan hyaluronan, which plays a role in resistance to excessive flow of fluid within the Subcutaneous matrix, limiting massive volume SC drug delivery, dispersion, and absorption. Co-administration of recombinant Hyazyme with partner therapies can overcome administration time and volume barriers associated with existing SC therapeutic formulations.
[Effects of Jiangu granule containing serum on the cyclins in rat's osteoblast at G1 phase].

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

JGG-serum can adjust the G1 phase cyclins in osteoblast cultured in vitro, increase the mRNA and protein expressions of Cyclin D1 and CDK4, and inhibit P21 expression, so as to accelerate the proliferation of osteoblast.
Administering learning environments in the twenty‐first century

Field: Social Sciences (Social Sciences)

Educational administration is the challenging field of study which deals with educational organizations, educational activities, and the individuals who lead and/or maintain them. This field/discipline includes the development of skills necessary to improve the administrative performance of those who choose to prepare for or who are engaged in the administration of learning environments (defined as a single school district or unit governed by a single group of trustees). The field is searching and struggling as it nears the twenty-first century. There is a growing concern about the ability of graduate programs to prepare educational leaders for the' next century. In the last quarter century, great strides have been made in both academic study and the training functions of educational administration. Few, if any, higher education programs in educational administration in the United States and in other countries have been unaffected by the changes brought about by scholars and professional associations. Concerned leaders armed with vision and Kellogg Foundation support laid the cornerstone for theory building and produced the major portion of the content taught in graduate programs and seminars. Within a few productive years, leading professors' lectures were transformed from war stories of how
An instrument for measuring the critical factors of TQM in Turkish higher education

Field: Business, Management and Accounting (Social Sciences)

Driven by increasing competition and intensifying market forces, higher education institutes (HEIs) find total quality management (TQM) as one of the indispensable tools to adapt to the evolving new educational environment and to fulfil the expectations of their stakeholders. Based on a thorough review and synthesis of the quality management literature, this paper identifies 11 critical areas of TQM in an HEI. Operational measures of the critical factors are developed that can be used individually or in concert to produce a profile of institution-wide quality management. These measures are tested for reliability and validity using perceptual data collected from a sample of 144 academics from 22 HEIs in Istanbul, Turkey. Decision makers will be able to use this instrument to identify the extent of TQM implementation in their institutions, while researchers will be able to use it for furthering TQM research in HEIs.
Cell Types Involved in Collagen and Fibronectin Production in Normal and Fibrotic Human Liver

Field: Medicine (Health Sciences)

Three collagen types (I, III and IV) and fibronectin were localized in normal and alcoholic human liver by light and electron microscopy using the indirect immunoperoxidase technique. In normal liver, most of the bundles of collagen fibers stained for type pro–III collagen while only a few reacted for type I. Basement membranes stainedfor type IV collagen which formed discontinuous discrete deposits in sinusoids. Only fibronectin appeared as an almost continuous layer in the space of Disse. At the intracellular level, hepatocytes were found to contain little type I collagen and large amountsof fibronectin. Fat–storing cells strongly stained for type IV collagen and expressed low amounts of types I and III collagen and fibronectin. Endothelial cells contained low amounts of all the components. Alcoholic livers were studied at three stages: steatosis, fibrosis and cirrhosis. Qualitative and quantitative differences were observed in extracellular and intracellulardistributions of matrix proteins. Increased amounts of all components were usually found in fibrotic and cirrhotic livers compared to normal liver. In two fibrotic livers which contained numerous bundles of collagen in the sinusoids, fat–storing cells stained more intensely for type III collagen. In a cryptogenic fibrotic liver, abundant type IV collagen was observed in hepatocytes. These results suggest that hepatocytes, fat–storing cells and endothelial cells are engaged in production of extracellular matrix components in normal human liver. In fibrosis, hepatocytes which normally did not synthesize types III and IV collagen mayproduce these collagens.
Sequential reduced‐intensity chemotherapy for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia with rare cytogenetic abnormalities transformed from Fanconi anemia

Field: Medicine (Health Sciences)

Table S1. Studies of FA patients with advanced myeloid malignancy who did or did not receive chemotherapy prior to HSCT Table S2. Cases of pediatric acute myeloid leukemia with RUNX1-CBFA2T3 Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Heat Conductive Analysis of One Million DOFs Problem with Hierarchical Domain Decomposition Method

Field: Mathematics (Physical Sciences)

This paper describes the parallel finite element analysis of large scale problems for a heat conductive problem using parallel computers. In order to solve the issue of memory shortage and computational time, the developed system employs a dynamic load balancing and hierarchical distributed data management technique. The present system is successfully applied to large FEM analyses of over two million d.o.f. (degrees of freedom) on a PC cluster parallel computer consisting of 16 processing units.
Thirty Years of Charter Schools: What Does Lottery-Based Research Tell Us?

Field: Social Sciences (Social Sciences)

Charter schools can serve as "laboratories of innovation," generating evidence about effective educational practices via their random admissions lotteries. This paper synthesizes findings from charter school lottery-based studies and identifies future research priorities. Evidence shows charter schools can boost academic achievement and long-term outcomes, especially for lower-performing, nonwhite, low-income students and those with disabilities. However, these findings are limited to oversubscribed schools in urban areas. Future research should expand geographic coverage, update K-12 academic outcomes, and explore non-test-score outcomes, college, and earnings. Addressing these areas would strengthen evidence and inform education policymaking in the charter sector and beyond.
Plating Condition for Tungsten-Cobalt Alloys and Their Corrosion Resistance in Acid Solution

Field: Chemical Engineering (Physical Sciences)

The plating condition of W-Co alloys in citrate solution and the corrosion resistance of its alloys in acid solution were investigated.The result was as follows:1. Optimum composition of bath was Na2WO4⋅2H2O 60gl/, CoSO4⋅7H2O 20g/l, and sodium citrate 60g/l, from which the bright deposits containing about 50% tungsten were obtained at pH 8.0, current density 5A/dm2, and temperature 70°C.2. Alloy deposits and their tungsten contents were mainly affected by concentration of cobalt in the bath, but the effect of concentration of tungsten or sodium citrate was not so remarkable. When the plating was continued more than one hour, the deposits became grayish, and then occurred peeling.3. The corrosion resistance of W-Co alloy deposits was found to be fairly good in HCl and HNO3 solutions, like that of W-Fe alloy deposits. W-Ni alloy deposits, however, were inferior to bath W-Co and W-Fe alloy deposits.
Embracing Complexity in the Characterisation and Tracking of Neurodevelopment (ECCaToN): A Transdiagnostic Protocol

Field: Neuroscience (Life Sciences)

Abstract

Background. Neurodiverse diagnoses (NDs) are currently assessed through a variety of educational and/or medical pathways, all of which typically derive categorical diagnoses based on traditional diagnostic classification systems. However, converging research evidence has shown that this conventional approach inadequately captures the individual variation and overlaps that are commonly observed across NDs in their underlying dimensions. The purpose of this study is to build upon the emerging quantitative research framework, through adopting a transdiagnostic dimensional approach to characterising the complexity of the cognitive and affective dimensions that underpin broadly sampled NDs. Methods. A cohort of approximately 200 individuals (aged 16–50), who had been referred for assessment and/or sought help from support services for suspected or previously diagnosed developmental differences, is being recruited using convenience sampling. The cognitive domains of executive function, language, attention, processing speed and memory are being assessed using the National Institute of Health (NIH) Cognition Toolbox©. A mental health battery consisting of the Extended Strengths and Weaknesses Assessment of Normal Behaviour (E-SWAN), Strengths and Difficulties Questionnaire (SDQ) and Emotion Regulation Skills Questionnaire (ERSQ) is being administered to provide additional information on the internalising, externalising and emotion regulation dimensions of the affective difficulties that commonly co-occur with NDs. Data reduction techniques, clustering and dynamic network modelling, will be used to identify and explore the interactions between data-driven transdiagnostic clusters of individual cognitive and mental health profiles. Discussion . This study protocol allows for the exploration of developmental difficulties that cut across diagnostic boundaries, offering the potential to more precisely characterise the mechanisms underlying the complexity of NDs (in terms of co-occurring conditions, between-diagnosis overlaps and individual variation), beyond that offered by traditional case-control study designs. Ultimately, transdiagnostic research may provide the opportunity to identify individual areas of need that may serve as targets for future interventions, and potentially aid in enhancing diagnostic sensitivity to a variety of NDs.
The effects of small and medium-sized tourism enterprises on destinations

Field: Social Sciences (Social Sciences)

Because of their contribution to the economy, small and medium-sized enterprises (SMEs) have received increased attention from governments during recent years. They have been the driving force for economies, especially those of developing countries. Small businesses are also acknowledged as both the foundation and components of large enterprises. Tourism SMEs also play a significant role in the tourism industry, not only for the sustainability of the destinations they operate, but also because they provide opportunities for local subsectors in the industry. They have considerable effects on the socio-cultural life, sustainability and economies of the countries as well. Destination is an amalgam of products and services that come together to meet the needs and desires of tourists. Small and medium-sized tourism enterprises (SMTEs) are able to offer these products and services in an authentic and sustainable way. As local enterprises (local ownership and local procurement), these businesses make an important contribution to sustainable development of the destination. Besides, it is known that their negative environmental impacts are smaller than those of large enterprises. SMTEs can also lead to positive economic effects by ensuring that local people are employed within the tourism industry. As well as minimizing leakages, local entrepreneurship enhances the multiplier effect. In addition, SMTEs ensure that tourism expenditures are integrated quickly into the local economy. Besides their economic outcomes, social development can be experienced in destinations where SMTEs are more active (establishment of institutions such as schools and hospitals, the realization of infrastructure investments) as well as social prosperity. Increasing woman participation due to these businesses is also critical in terms of changing social life. In addition to the positive effects on the destination, there are some negative effects as well. Among these are the excessive increase in the number of enterprises, administrative insufficiency, falling prices and decrease in quality level due to the competition, socio-cultural corruption and an increase in the informal economy. In this chapter, SMTEs are explained within this conceptual framework, and the importance and effects of SMTEs, in terms of destinations, are emphasized.
PENERAPAN MANAGEMEN STRATEGI KEPALA MADRASAH DALAM MENINGKATKAN KOMPETENSI PEDAGOGIC GURU DI MI MARAQITT’LIMAT SANTONG LOMBOK UTARA

Field: Social Sciences (Social Sciences)

Strategic management of education is the implementation of education related to all educational material needs which are at the same time related to all aspects that exist in the effort to provide education, which is directly related to the learning process, facilities, or facilities and infrastructure Strategic Management aims to direct all company resources to be aligned and effective in achieving company goals. In the world of education, management is indispensable, through strategic management can expand future opportunities and minimize realized risks. Therefore an organization, company or educational institution must have a leader (leader) to determine the direction, and goals of an organization by providing direction in creating a supportive work climate for the implementation of the overall management process Pedagogic competence is the ability of teachers in managing student learning In the field of education needed by a teacher, namely pedagogic competence in seeing the characteristics of students from various aspects of life, be it moral, emotional, or intellectual. And with the presence of pedagogic competence of teachers will increase the competence of teacher professionalism in teaching. This study uses a research approach with methods applied to collect data, namely observation, interviews, and documentation. While the data analysis techniques used are data collection, data reduction, analysis, data presentation, and drawing conclusions. While the technical validity of data is used data trianggulation, method trianggulation, and theory trianggulation. The data obtained in this study is the application of the strategy management of the head of the madrasah in improving the pedagogic competence of teachers is good, and as for what is obtained by teachers through efforts to implement the management of the strategy of the head of the madrasah in improving the pedagogic competence of teachers is categorized as good.
Equilibrium strategies of sharing CSR in a supply chain with manufacturer encroachment

Field: Business, Management and Accounting (Social Sciences)

Purpose Motivated by the real-world practice of the thriving e-commerce, manufacturers are transcending traditional boundaries of merely producing and selling directly by implementing encroachment. Concurrently, supply chain (SC) members who overlook the corporate social responsibility (CSR) sharing will be left behind, which is closely linked to their profits. This paper aims to investigate a better way to share CSR under the scenarios of manufacturer encroachment and no-encroachment. Design/methodology/approach This paper constructs game-theoretic models in a SC consisting of a manufacturer (M) and a retailer (R), where the manufacturer can sell products by retailing, and may sell directly by implicating encroachment. The manufacturer and retailer jointly consider whether to share CSR and the proportion of it by taking consumer surplus into account. Furthermore, equilibriums for each model are derived using backward induction. Then, the authors analyse the impact of CSR sharing proportion and compare the equilibrium outcomes under different scenarios. Finally, the numerical analyses are presented to verify the results. Findings Several interesting results are found in this paper. First, the retailer shares more CSR can benefit SC members and social welfare when the manufacturer does not implement encroachment. However, the results may change which is decided by the unit cost of encroachment when the manufacturer does so. Second, the proportion of CSR shared by manufacturer and the unit cost of encroachment has an interactive impact on equilibrium outcomes. Finally, both manufacturer encroachment and SC members share CSR may be the best for the perspective of SC members and consumers. Practical implications Based on the analytical results, this paper provides novel managerial implications to assist manufacturer and retailer in determining the optimal strategies for CSR sharing and encroachment. Furthermore, the appropriate proportion of CSR shared by manufacturer and the unit cost of encroachment may let manufacturer, retailer and consumer surplus achieve a win-win-win situation. Originality/value To the best of the authors’ knowledge, this paper is the first attempt to explore the strategy of CSR sharing under the scenarios of manufacturer encroachment and no-encroachment.
Addressing the Irrational Drivers of the Climate Crisis

Field: Social Sciences (Social Sciences)

Abstract An increasing number of scientists have illustrated how economic growth is an underlying driver of the climate crisis. This article examines how associated levels of excess work, production, and consumption repress human flourishing and drive global warming. Drawing from the work of Herbert Marcuse and André Gorz, we discuss the irrationality of a system of excess work, production, and consumption in terms of unnecessary human repression and environmental destruction. In the context of the climate crisis, this system becomes even more irrational as it threatens the habitability of Earth for humans. We examine work-time reduction and related sufficiency measures as a rational response to the climate crisis.
Figure S5 from Chemokine analysis in patients with metastatic uveal melanoma suggests a role for CCL21 signaling in combined epigenetic therapy and checkpoint immunotherapy

Field: Medicine (Health Sciences)

<p>Figure S5. Immunohistochemistry magenta of a) Immunohistochemistry magenta showing CCL21 and corresponding CCR7 expression within tumor biopsies for patient 1-013 and 3-009. b) Patient 1-013, a lymph node biopsy showing CD20, CD3 and CCL21 staining with serial sections. c) Patient 2-027, a liver met biopsy showing SOX10, CCR7, TK1 and PDL1 (DAB) within the same areas as shown in Fig 6.</p>
Unusual presentation of crusted scabies with osteolysis in immunocompetent

Field: Medicine (Health Sciences)

Abstract Background Crusted scabies results from a failure of the host immune response to control the proliferation of the scabies mite in the skin, with resulting hyperinfestation and a concomitant inflammatory and hyper‐keratotic reaction. However, it has also been recognised in people with no evident immunological deficit. Case history We present a case report of apparently immunocompetent 16‐year‐old female presenting with multiple hyperkeratotic vegetating plaques over limbs, excoriated papules over trunk with minimal itching since 2 years without any positive family history. The microscopic examination of the skin scales with potassium hydroxide demonstrated numerous scabies mites and eggs. Histopathology showed hyperkeratosis with multiple mites in stratum corneum. Numerous mites were seen on biopsy of lesion. X‐ray showed osteolysis of distal phalanges secondary to chronic pressure. Repeated topical treatments with permethrin and oral ivermectin led to the considerable resolution of her lesions. Conclusion We present a rare case of crusted scabies with osteolysis in an immunocompetent female.
The shape of European jazz: On mute, mutable and pedagogical musical representations

Field: Arts and Humanities (Social Sciences)

Readers of comics can easily call to mind images of musical notation they have seen on the page. It is a cliché of the medium that a speech balloon bearing a pair of quarter notes usually hovers near a singing bird, and it is no less common that floods of eighth, quarter, half and whole notes emanate from a turntable speaker or the bell of a saxophone drawn inside the panel borders. Yet the ways in which musical notation and musical expression take shape on the comics page are highly contextualized. For those comics that move beyond stereotypical depictions of musical sounds, how musical notes and emanations are depicted on the page are closely connected with the theme, critical aspirations and sociocultural context of a given work. Focusing on the representation of Black American jazz music in particular, and its transatlantic resonance in Europe (Germany, France and Spain) during the twentieth century, this article investigates three divergent manifestations of this phenomenon. By analysing innovative examples of musical representation from Berlin (Jason Lutes), Total Jazz (Blutch) and Montoliu Plays Tete (Gani Jakupi and Miquel Jurado), a basic typology is offered of mute, mutable and pedagogical representations of music in which comics form, audience reception and social context are interconnected.