jimnoneill/paper-to-field-training huggingface dataset:
A Tyrosine Kinase Expression Signature Predicts the Post-Operative Clinical Outcome in Triple Negative Breast Cancers

Field: Medicine (Health Sciences)

Triple negative breast cancer (TNBC) represent 15% of breast cancers. Histoclinical features and marketed prognostic gene expression signatures (GES) failed to identify good- and poor-prognosis patients. Tyrosine kinases (TK) represent potential prognostic and/or therapeutic targets for TNBC. We sought to define a prognostic TK GES in a large series of TNBC. mRNA expression and histoclinical data of 6379 early BCs were collected from 16 datasets. We searched for a TK-based GES associated with disease-free survival (DFS) and tested its robustness in an independent validation set. A total of 1226 samples were TNBC. In the learning set of samples (N = 825), we identified a 13-TK GES associated with DFS. This GES was associated with cell proliferation and immune response. In multivariate analysis, it outperformed the previously published GESs and classical prognostic factors in the validation set (N = 401), in which the patients classified as “low-risk” had a 73% 5-year DFS versus 53% for “high-risk” patients (p = 1.85 × 10−3). The generation of 100,000 random 13-gene signatures by a resampling scheme showed the non-random nature of our classifier, which was also prognostic for overall survival in multivariate analysis. We identified a robust and non-random 13-TK GES that separated TNBC into subgroups of different prognosis. Clinical and functional validations are warranted.
The Effects of Tillage, Glyphosate, and Genetic Modification on Bacterial Root Endophyte Composition in Zea Mays

Field: Agricultural and Biological Sciences (Life Sciences)

The community structure of the endophytic bacteria in Zea mays roots was examined for the potential effects of glyphosate application, tillage strategies, and whether or not the corn plant in question was of an organic or glyphosate-resistant variety. Roots were harvested from plots designated to receive their specific treatments at the USDA-ARS Crop Production Systems Research Unit Farm. Vortexing, sonication, and tissue grinding, extraction, and next generation sequencing of 16S rRNA genes from these roots were used to describe their bacterial community composition. Results indicated significant differences in the bacterial communities correlated to tillage practice or corn type, whereas glyphosate treatments did not seem to affect the bacterial community. There also appeared to be certain holistic differences resulting from the combinations of certain treatments. Prior research has focused primarily on fungal endophytes, but as 16S rRNA sequencing has immeasurably broadened the scope of microbiological studies, new research such as this seeks to identify new microbes and their potential functions in the macroscopic world.
Factor-specific modulation of CREB-binding protein acetyltransferase activity (p300/CBP interacting proteinyp300/CBP associated factoryE1A)

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

CREB-binding proteins (CBP) and p300 are essential transcriptional coactivators for a large number of regulated DNA-binding transcription factors, including CREB, nuclear receptors, and STATs. CBP and p300 function in part by mediating the assembly of multiprotein complexes that contain additional cofactors such as p300yCBP interact- ing protein (pyCIP), a member of the p160ySRC family of coactivators, and the p300yCBP associated factor pyCAF. In addition to serving as molecular scaffolds, CBP and p300 each possess intrinsic acetyltransferase activities that are required for their function as coactivators. Here we report that the adenovirus E1A protein inhibits the acetyltransferase activity of CBP on binding to the CyH3 domain, whereas binding of CREB, or a CREByE1A fusion protein to the KIX domain, fails to inhibit CBP acetyltransferase activity. Surprisingly, pyCIP can either inhibit or stimulate CBP acetyltransferase activity depending on the specific substrate evaluated and the functional domains present in the pyCIP protein. While the CBP interaction domain of pyCIP inhibits acetylation of histones H3, H4, or high mobility group by CBP, it enhances acetylation of other substrates, such as Pit-1. These observa- tions suggest that the acetyltransferase activities of CBPyp300 and pyCAF can be differentially modulated by factors binding to distinct regions of CBPyp300. Because these interactions are likely to result in differential effects on the coactivator functions of CBPyp300 for different classes of transcription factors, regulation of CBPyp300 acetyltransferase activity may represent a mechanism for integration of diverse signal- ing pathways.
“YOUR VILE SUBURBS CAN OFFER NOTHING BUT THE DEADNESS OF THE GRAVE”: THE STEREOTYPING OF EARLY VICTORIAN SUBURBIA

Field: Arts and Humanities (Social Sciences)

While literary critics have become increasingly engaged by the impact of suburbanization on the literary landscape, most scholarship has focused on texts from the late-nineteenth and early-twentieth centuries. The belief that suburbia appeared only occasionally in literature before this period is commonplace: as Gail Cunningham observes: “Although the term ‘suburb’ was used from Shakespeare and Milton onwards . . . it was not until the final decades of the nineteenth century that writers turned to suburban life as a subject of imaginative investigation” (Cunningham, “Riddle” 51). Cunningham's important work on suburban narrative positions authors of the late nineteenth century as architects of “the new imaginative category suburban,” one that was substantially shaped by the experience of observing and living amongst “newly massed middle classes” (Cunningham, “Riddle” 52). “[F]or many writers . . . the prime response to the new suburbia was one of anxiety and disorientation,” she argues. “How were they to conceptualize the sudden appearance of the new spatial environment?” (Cunningham, “Houses” 423). Yet Cunningham's emphasis on the newness of both the category and the lived experience underestimates the impact of suburbanization on the totality of the period. Suburbanization was a phenomenon that Victorian society had been experiencing, and responding to, for at least eight decades by the time of Victoria's death. Literary narratives engaging suburbia from these eight decades undoubtedly exist: they have received scant critical attention, yet they constitute a crucial tradition without which the most famous late-nineteenth-century texts of suburbia cannot be adequately understood.
A Comparison of Mean Time to Request for First Analgesia Post-Operatively in Functional Endoscopic Sinus Surgeries (Fess) by Using Pre-Emptive Paracetamol Versus Intraoperative Paracetamol

Field: Medicine (Health Sciences)

Objective: To compare mean time required to request for first analgesia post-operatively in functional endoscopic sinus surgeries (FESS) by using pre-emptive paracetamol versus intra-operative paracetamol. Study Design: Comparative Observational Study. Sampling Technique: Non probable, consecutive sampling Place & Duartion: This Study was conducted in the Department of Anesthesiology, Sindh employee’s social security hospital landhi Karachi, From June, 2018 to January, 2019. Materials and Methods: In this study 64 patients of both genders included. 36 patients were male and 28 were females. They were aged between 18 and 70 years. This study was conducted from June, 2018 to January, 2019. Patients were distributed into two different groups, Group-1 (pre-emptive paracetamol) and Group-2 (intra-operative paracetamol). 32 patients were included in each group. In Group-1 (pre-emptive paracetamol), patients received 1 Gm. I/V paracetamol, 15 minutes prior to induction of general anesthesia and in Group-2 (intra-operative paracetamol), patients received 1gm. I/V paracetamol just before removal of endotracheal tube. Post-operatively patients were observed in Post-Anesthesia Care Unit (PACU) with standard monitoring. Time for first request for analgesia in minutes was noted. Result: SPSS 16 version used for statistical analysis. Chi squire test applied. Mean age of in pre-emptive paracetamol group (group-1) was 51.53 + 18.90 years and mean age of patients in intra-operative paracetamol group, was 50.43 + 19.10 years (p-value 0.819). Mean weight of patients in pre-emptive paracetamol was 66.65 + 10.74 kg and mean weight of the patients in intra-operative paracetamol was 67.71 + 10.78 kg. (P-value was 0.694). ASA status 1 was found in 36 (56.30%) patients and ASA status II was found in 28 (43.80%) patients. Mean time required for first analgesia in pre-emptive paracetamol group was 192.90 + 8.70 minutes and mean time required for first analgesia in intra-operative paracetamol group was 163.93 + 13.57 minutes and p-value found < 0.001 (significant). Conclusion: Significant variance was observed in the mean time required to request for first analgesia post-operatively in functional endoscopic sinus surgeries (FESS) by using pre-emptive paracetamol versus intra-operative paracetamol. Keywords: pre-emptive versus intraoperative paracetamol, functional endoscopic sinus surgeries, time required to request for first analgesia post-operatively.
Robust Timing Synchronization Algorithm for 5G New Radio

Field: Computer Science (Physical Sciences)

In this paper, we first introduce the 5G new radio (NR) frame structure and synchronization signals. In the literature, there are some conventional synchronization algorithms including the autocorrelation algorithm and the cross-correlation algorithm. Although the cross-correlation algorithm outperforms the autocorrelation algorithm, the performance of the cross-correlation algorithm is significantly affected by the carrier frequency offset (CFO). In this paper, we propose a novel algorithm that is robust to the CFO and has better performance than the autocorrelation algorithm. The simulation results demonstrate that the proposed algorithm performs well when CFO is introduced.
Mediastinorrhaphy after murine pneumonectomy increases post-operative work of breathing

Field: Medicine (Health Sciences)

Gibney, Barry DO; Houdek, Jan; Lee, Grace MD; Chamoto, Kenji PhD; Ackermann, Maximilian MD; Lin, Miao MD; Collings-Simpson, Dinee MD; Konerding, Mortiz MD; Tsuda, Akira PhD; Mentzer, Steven MD Author Information
Relationship between dietary diversity and oral frailty in elderly gynecologic tumor patients

Field: Health Professions (Health Sciences)

This study explores the relationship between dietary diversity and oral frailty in elderly gynecologic tumor patients. A total of 180 gynecologic tumor patients treated in our hospital from January 2021 to December 2024 were selected. Patients were divided into an oral frailty group (n = 71) and a non-oral frailty group (n = 109) based on the occurrence of oral frailty ( ≥ 4). Influencing factors were analyzed using univariate and binary logistic regression analysis. The correlation between variables was assessed with Pearson correlation analysis. The predictive value of Dietary Diversity Score (DDS) for the occurrence of oral frailty in elderly gynecologic tumor patients was evaluated using the receiver operating characteristic curve, and the dietary intake of patients with different oral frailty statuses was observed. The average DDS score among the 180 patients was 3.96 ± 1.39. There was no statistically significant difference in DDS among patients with different general characteristics ( P > .05). Similarly, there was no statistically significant difference in general characteristics between the oral frailty group and the non-oral frailty group ( P > .05). However, a statistically significant difference was observed between DDS and smoking status ( P < .05). Binary logistic regression analysis indicated that DDS was a significant factor influencing the occurrence of oral frailty in elderly gynecologic tumor patients ( P < .05). Receiver operating characteristic analysis showed that the area under the DDS predictive curve was 0.883, with a standard error of 0.025 (95% confidence interval: 0.834–0.932, P < .001); the Youden index was 0.60, with a sensitivity of 70.42% and specificity of 89.91%. The optimal cutoff value was 4.5. There was no statistically significant difference in the intake of eggs, fish, milk, and dairy products ( P > .05), while there were statistically significant differences in the intake of meat, legumes, yogurt, vegetables, and fruits ( P < .05). Pearson linear correlation analysis showed that Oral Frailty Index-8 was negatively correlated with vegetable intake, fruit intake, and DDS ( r = −0.300, −0.233, −0.338, respectively; P < .05). Increased severity of oral frailty in elderly gynecologic tumor patients is associated with reduced dietary diversity.
Elementary Mainstream Classroom Teachers’ Perceptions and Teaching Practice towards English Language Learners

Field: Social Sciences (Social Sciences)

Teaching in the Toronto District School Boards (TDSB), the largest school board in Canada with the most diverse student population, many mainstream classroom teachers feel that they are not equipped with adequate knowledge to teach and support English language learners (ELLs) in their classrooms. This qualitative research used a literature review and two face-to-face interviews to investigate this issue, focused around teachers’ preparation and knowledge, effective teaching strategies, and personal learning experience. The findings of the study indicated the importance for mainstream classroom teachers to encompass appropriate pedagogical, theoretical, and cultural knowledge through professional development in order to provide ELLs with sufficient support to be successful.
Model of Sharing Information in Supply Chain Network based on Metcalfe's Law

Field: Decision Sciences (Social Sciences)

Aimed at the problem in measuring the utility value of supply chain network in information sharing, this paper proposed a utility value model of supply chain network based on different information sharing strategies.Through the analysis of the research status of sharing information in supply chain at present stage, this paper discusses the feasibility of applying Metcalfe's law to measure the utility value of network which was generated by information sharing in the supply chain network.In a supply chain network composed of retailers and multiple vendors as the research object, it also explained respectively the method for measuring the utility value of supply chain network when the sharing arise between "supplier-retailer" and "supplier-supplier-retailer" and calculated the utility value of network under the different information sharing strategies of the supply chain network with the number of suppliers within 30.This model further validated that the utility value of supply chain network is directly proportional to the number of enterprises nodes in a network and the full information sharing of supply chain network is the most desirable strategy to improve the efficiency of supply chain network.
Analytical software design : introduction and industrial experience report

Field: Computer Science (Physical Sciences)

Analytical Software Design (ASD) is a design approach that combines formal and empirical methods for developing mathematically verified software systems. Unlike conventional design methods, the design phase is extended with more formal techniques, so that flaws are detected earlier, thereby reducing the time needed for coding, testing, and integration. In this paper, we demonstrate formal details and concepts behind the ASD approach, report about our experience with applying ASD in industrial control applications within Philips Healthcare, and discuss results and findings gathered during this work as well as some commonly faced issues and their practical solutions.
The Quṭb al-Dīn al-Shīrāzī (d. 710/1311) Codex (Ms. Mar'ashī 12868)

Field: Arts and Humanities (Social Sciences)

Les fonds des manuscrits dans le monde conservent de nombreux textes transcrits de la main de Qutb al-Dīn al-Shīrāzī (634/1236-710/1311), l'un des savants les plus renommes du monde islamique oriental au cours de la fin du VII e /XIll e et le debut du VIII e /XlV e siecles. Cet auteur est egalement connu pour avoir ecrit en 685/1286, a Konya, un recueil (majmu'a). Pendant longtemps, notre connaissance de ce volume se reduisait aux donnees fournies par un exemplaire incomplet copie en 1060/1650 et conserve aujourd'hui dans les fonds de la Bibliotheque du Parlement a Teheran (Ms. Majlis 593). Mais, le volume transcrit de la main meme de Qutb al-Dīn al-Shīrāzī a recemment refait surface; il est actuellement dans la possession de la Grande Bibliotheque de l'Āyat Allāh al-'uzma Mar'ashi Najafi a Qum (Ms. Mar'ashi 12868). Les similitudes textuelles entre le Codex Shīrāzī et un autre volume faisant partie de la Collection Fâtih, aujourd'hui a la Bibliotheque Suleymaniye a Istanbul (Ms. Fâtih 3141), suggerent que ce dernier volume, copie par Taj al-Din al-Kirmani, disciple de Qutb al-Din al-Shirazi. a egalement ete transcrit du Codex Shirazi, meme si le copiste n'indique pas sa source. Le present article contient la description detaillee du Codex Shīrāzī.
Occupational Asthma Induced by Chrysonilia sitophila in a Worker Exposed to Coffee Grounds

Field: Medicine (Health Sciences)

ABSTRACT A new case of occupational asthma caused by Chrysonilia sitophila (asexual state of Neurospora sitophila ) was diagnosed by molecular identification of the mold and confirmed by skin prick test, peak expiratory flow rate measurements, and experimental immunoglobulin E analysis.
Circadian rhythm effect on physical tennis performance in trained male players

Field: Medicine (Health Sciences)

To determine the effect of circadian rhythm on neuromuscular responses and kinematics related to physical tennis performance, after a standardised warm-up, 13 highly competitive male tennis players were tested twice for serve velocity/accuracy (SVA), countermovement vertical jump (CMJ), isometric handgrip strength (IS), agility T-test (AGIL) and a 10-m sprint (10-m RUN). In a randomised, counter-balance order, tennis players underwent the test battery twice, either in the morning (i.e., AM; 9:00 h) and in the afternoon (i.e., PM; 16:30 h). Paired t-tests were used to analyse differences due to time-of-day in performance variables. Comparison of morning versus afternoon testing revealed that SVA (168.5 ± 6.5 vs. 175.2 ± 6.1 km · h-1; P = 0.003; effect size [ES] = 1.07), CMJ (32.2 ± 0.9 vs. 33.7 ± 1.1 cm; P = 0.018; ES = 1.46), AGIL (10.14 ± 0.1 vs. 9.91 ± 0.2 s; P = 0.007; ES = 1.23) and 10-m RUN time (1.74 ± 0.1 vs. 1.69 ± 0.1 s; P = 0.021; ES = 0.67) were significantly blunted during the morning testing. However, IS was not affected by time-of-day (P = 0.891). Thus, tennis performance may be reduced when competing in the morning in comparison to early evening. Therefore, coaches and tennis players should focus on schedule the SVA, power, speed and agility training sessions in the afternoon.
Adapting children’s literature for animated TV series: The case of Heidi

Field: Arts and Humanities (Social Sciences)

Abstract Children’s literature includes some classics that are pervasive, thanks to media adaptations that have made them known worldwide such as, among many, Alice’s Adventures in Wonderland (Carrol 1865), Peter Pan in Kensington Gardens (Barrie 1906), and Charlie and the Chocolate Factory (Dahl 1964). It is not by chance that with each new generation, fresh adaptations of children’s classics appear. The following article will focus on the specifics of writing for animated TV series aimed at a children’s audience, comparing two adaptations of Johanna Spyri’s 1880 Swiss novel Heidi: Arupusu no Shôjo Haiji, Heidi (Heidi, Girl of the Alps) (Fuji TV, 1974) and its 3D reboot Heidi (TF1, 2015). Heidi, Girl of the Alps first appeared in Japan in 1974, marking the beginning of the so-called ‘anime-boom’ that lasted till the mid-1980s. The series, comprised of 52 episodes, was produced by Zuiyo Enterprises. Directed by Isao Takahata, it boasts the drawings of Oscar winner Hayao Miyazaki and can be considered the initiator of the ‘Meisaku’ genre, also known as the World Masterpiece Theatre that showcased animated versions of the most beloved western children’s novels. Heidi 3D, instead, is a CGI animation remake of the 1974 anime adaptation, and was produced by Studio 100 in 39 episodes. In this version, Heidi appears as a modernized, more colourful 3D incarnation of herself. The comparison between the two adaptations will show not only how the original material has changed in the transition from one series to the other, but also how animation affects the way in which a story for television is told and plays a role in keeping classic stories ever-new.
Comparative immunological study of of lamellar and penetrating keratoplasty in murine model

Field: Immunology and Microbiology (Life Sciences)

Abstract Purpose Lamellar keratoplasty (LK) has been considered an acceptable alternative surgery for penetrating keratoplasty (PKP), because LK has the advantage of lower risk of graft rejection and intraocular complications, according to recent clinical outcomes. But the relative immunological mechanism of graft rejections for the two procedures is uncertain. We have developed a murine model of lamellar keratoplasty to try to understand the immunological mechanisms of those two procedures. Methods We have developed a murine model of lamellar keratoplasty to try to understand the immunological mechanisms of those two procedures through real‐time PCR, immunohistochenistry, and flow cytometric analysis. Results LK mice showed less graft rejection than PK mice and LK led to less DTH response and IFN‐γsecretion in vitro recall assay of T cells from drainage lymph nodes, as compared to PK (acceptance; acc). Corneal expression of IL‐1β and IFN‐γ in PKacc were significantly increased later. In addition, LK showed less angiogenesis and lymphangiogenesis in grafted cornea than PK, and LK led to decreased number of MHCIIhighCD11c+ antigen presenting cells(APCs) in the draining LNs. Conclusion In conclusion, these results show that LK presents less graft rejection than PK through lower angiogenesis and lymphangiogenesis, which could make pathologic T cells and APC less migration into drainage LNs and grafted corneas, respectively.
Optimizing nitrogen estimates in common bean canopies throughout key growth stages via fusion of spectral and textural data from unmanned aerial vehicle (UAV) multispectral imagery

Field: Agricultural and Biological Sciences (Life Sciences)

This study investigates the potential of utilizing multispectral imagery acquired from unmanned aerial vehicles (UAVs) to enhance the accuracy of leaf nitrogen content (LNC) estimation, a crucial parameter for assessing crop nitrogen status and guiding nitrogen management practices. We integrated selected vegetation indices (VIs) and texture data (gray level co-occurrence matrix - GLCM) derived from UAV-based multispectral images to estimate LNC in common bean (Phaseolus vulgaris L.). Therefore, the objectives of this study were (i) to determine the optimal VIs and texture metrics from UAV multispectral imagery for estimating LNC, and (ii) to explore the capability of integrating spectral and textural information in the improvement of N status monitoring.