jimnoneill/paper-to-field-training huggingface dataset:
Supplementary_Table - Comparison Between Treacher Collins Syndrome and Pierre Robin Sequence: A Cephalometric Study

Field: Dentistry (Health Sciences)

Supplementary_Table for Comparison Between Treacher Collins Syndrome and Pierre Robin Sequence: A Cephalometric Study by Renata Mayumi Kato, Priscila Padilha Moura, Roseli Maria Zechi-Ceide, Cristiano Tonello, Adriano Porto Peixoto and Daniela Garib in The Cleft Palate-Craniofacial Journal
Roles of mitochondria in cancer targeting therapeutics.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Dysfunctions of mitochondria have been implicated as the important factor of a wide variety of diseases. Significantly, mitochondrion has emerged as the potential targets for cancer targeting therapeutics. In particular, recent findings show that reversible protein phosphorylation, which is a crucial but largely overlooked means of mitochondrial post translational modification, regulates the mitochondrial functions in the oncogenic signaling network. Comprehensive understanding of mitochondrial phosphoproteomics will thus help in breakthrough of cancer therapy. Nonetheless the substoichiometric level of protein phosphorylation largely hinders the global analysis of mitochondrial phosphoproteome. Here we report optimization of several phosphopeptide enrichment approaches including batchwise IMAC, TiO2, ERLIC, SCX and ERLIC chromatography for efficient identification of phosphopeptides and phosphoproteins. A novel combinatorial enrichment strategy that couples SDS-PAGE to batchwise ERLIC, IMAC and TiO2 sequentially has been developed to enrich for phosphopeptides of SNU1 and SNU5 cancer cells mitochondria. Finally we identified 403 and 356 phosphoproteins in SNU1 and SNU5 mitochondria respectively. A list of 44 important phosphoproteins is summarized. These results revealed diverse crucial phosphorylation activities involved in the regulation of mitochondrial functions in cancer cells.
Body mass and kicking velocity is significantly correlated to front kicking, but not roundhouse kicking performance in amateur male kick boxers

Field: Medicine (Health Sciences)

Despite the increasing popularity of kickboxing and associated combat sports, no studies to date have examined fieldbased performance tests that may influence roundhouse and front kicking performance. The aim of the present study was to investigate the relationships between field-based measures of mean kicking velocity, lower limb strength, lower limb power, and mean front and roundhouse kicking impact power. A cross-sectional study design assessed the following variables: anthropometrics, mean kicking velocity, single-leg isometric strength, single-leg jumping power, and both roundhouse and front kick impact power. Ten amateur male kickboxing athletes (30.7 ± 9.2 yrs., 178.6 ± 0.6 cm, 82.9 ± 8.3 kg) performed repeated trials of front and roundhouse kicking to determine velocity and impact power followed by single leg strength and single leg countermovement jump tests. Significant bivariate correlations were observed between preferred leg front kick impact power and body mass (r=0.75, p<0.05) and between preferred stance leg front kick impact power and kicking velocity (r=0.80, P<0.05). The results of this study suggest both single leg isometric strength and single leg countermovement jump power do not influence front or roundhouse kicking impact power. Therefore, strength and Conditioning coaches should prioritize the technical aspects of kickboxing training, when working to improve front and roundhouse kick performance.
Effects of codon optimization and glycosylation on the high-level production of hydroxynitrile lyase from Chamberlinius hualienensis in Pichia pastoris

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract A hydroxynitrile lyase (HNL) from the millipede Chamberlinius hualienensis has high potential for industrial use in the synthesis of cyanohydrins. However, obtaining sufficient amounts of millipedes is difficult, and the production of the Chamberlinius hualienensis HNL (ChuaHNL) in E. coli has not been very successful. Therefore, we investigated the conditions required for high-yield heterologous production of this enzyme using Pichia pastoris. When we employed P. pastoris to express His-ChuaHNL, the yield was very low (22.6 ± 3.8 U/L culture). Hence, we investigated the effects of ChuaHNL codon optimization and the co-production of two protein disulfide isomerases (PDIs) [from P. pastoris (PpPDI) and C. hualienensis (ChuaPDI1, ChuaPDI2)] on His-ChuaHNL production. The productivity of His-ChuaHNL was increased approximately 140 times per unit culture to 3170 ± 144.7 U/L by the co-expression of codon-optimized ChuaHNL and PpPDI. Moreover, we revealed that the N-glycosylation on ChuaHNL had a large effect on the stability, enzyme secretion, and catalytic properties of ChuaHNL in P. pastoris. This study demonstrates an economical and efficient approach for the production of HNL, and the data show that glycosylation has a large effect on the enzyme properties and the P. pastoris expression system.
Effect of gamma radiation on some biological aspects and ultrastructure of female ovaries of the house fly, Musca domestica L. (Diptera: Muscidae)

Field: Agricultural and Biological Sciences (Life Sciences)

The present study aimed at evaluating the effect of lethal doses of gamma radiation (LD25, LD50 and LD75) on reproductive potential of females resulted from irradiated pupae, and the latent effect on first generation (F1). In addition, ultrastructure alterations in resulted female ovaries were studied using transmission electron microscope. The numbers of eggs laid were 158.3 and 70.0 eggs/5♀♀♀ at LD25 and LD50, respectively, compared with 536.7 eggs/5♀♀ for control, and while no eggs were deposited by females resulted from pupae exposed to LD75 of gamma radiation. Also, the sterility index recorded 94.0 and 77.7 at LD25, and LD50, respectively in F1 females. Otherwise, the growth index of F1 larvae and pupae recorded 7.2 and 6.4 at LD25 and LD50, respectively, compared with 8.7 for control. Gamma radiation affected the ultrastructure of resulted female ovaries such as degeneration of ovarian sheath, distortion, and irregularities in the outlines of follicular epithelial cells and lysis of oocyte. Also, shrinkage nuclei with the unclear components were observed, as well as dispersion of vacuoles around cytoplasm with irregularity and shrinkage of nurse cells. So, these radiation doses can be used in the Sterile Insect Technique (SIT) programs against Musca domestica.
The Role of Technology Assessment in Congressional Consideration of Biotechnology

Field: Social Sciences (Social Sciences)

This chapter focuses on technology assessment information pertaining to four important issues associated with biotechnology: the pending adoption of bovine somatotropin in the dairy industry, the status of patent rights for genetically engineered animals, the commercialization of biotechnology, and the Human Genome Initiative, a series of federally funded programs designed to map the human gene. The current biotechnology regulatory scheme, involves a variety of regulatory agencies depending on the application of biotechnology under consideration. There are three primary sources of technology assessment within Congress: the Office of Technology Assessment (OTA), General Accounting Office (GAO), and the Congressional Research Service (CRS). Congressional staff reports are an important source of technology information for policy makers. The case of biotechnology and its various episodes of debate reveal the importance of these agencies in shaping the contours of policy consideration by the nature of the involvement—or lack of involvement.
O konstytucyjnym pojęciu godności osobowej

Field: Arts and Humanities (Social Sciences)

The content of this publication is a presentation of the meaning of the formula which refers to human dignity. The understanding of this idea should always remain in accordance with the legislative and judicial acquis of countries of western civilisation sphere. Based on judicature and source literature, respective attributes of human dignity, which Article 30 of the Constitution of the Republic of Poland refers to, have been explained. A change of the attitudes of constitutional lawyers’ community and the Constitutional Tribunal has been highlighted, with the possibility of referring to the content of this article as an independent model of constitutionality of law under an abstract and concrete control. Initially, human dignity was considered as a general rule and not legal rights.
Slow accumulation of cyclosporin metabolites as measured by specific and nonspecific cyclosporin RIA.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Blood cyclosporin concentrations were measured by radioimmunoassay (RIA) using nonspecific polyclonal and specific monoclonal antibodies in 32 kidney transplant patients. Kinetics of cyclosporin concentrations after transplantation (day 0-2) and after long-term dosage (day 7-month 6) were evaluated by nonlinear regression analysis. Elimination and accumulation kinetics were linear and in agreement with one- or two-compartment kinetics. Only in 3 cases were saturable Michaelis-Menten kinetics observed (Vm = 23 ng/ml h-1, Km = 636 ng/ml). Bioavailability was 0.72 as estimated from first-pass extraction. The median values (5-95% CI) for the elimination half-life of nonspecific RIA concentrations increased from 5 h (2.5-6.2) on day 2 after transplantation to 10 h (9.2-11) after long-term dosage. The specific monoclonal antibody data revealed an elimination half-life of 6.4 h (5.6-7.7) for parent cyclosporin, which was unchanged after multiple dosing. After month 6, the elimination half-life of specific monoclonal antibody data was significantly shorter (p = 0.03) than elimination half-life of nonspecific RIA concentrations (6.6 vs 9.1 h). In relation to blood concentrations measured by nonspecific polyclonal antibody RIA, the fraction of parent cyclosporin significantly decreased from 84 percent (49-90) to 30 percent (24-52) after long-term dosage as measured by specific monoclonal antibody (p = 0.01). It is concluded that metabolites of cyclosporin accumulate in a slow compartment and, after long-term cyclosporin administration, nonspecific RIA blood concentrations are mainly contributed by cyclosporin metabolites.
Fatigue Rate During Anaerobic and Aerobic Exercise in Insulin-Dependent Diabetics and Nondiabetics

Field: Medicine (Health Sciences)

This study was designed to determine whether insulin-dependent diabetics fatigue at a different rate than nondiabetics during anaerobic and aerobic exercise. The rate of fatigue during cycle ergometer exercise at 90 percent (anaerobic) and 60 percent (aerobic) of predicted maximum oxygen consumption in eight men who were insulin-dependent diabetics and eight nondiabetic men was determined. For the insulin-dependent diabetics, performance at 90 percent was a significantly better predictor (p less than .05) of performance at 60 percent than it was for the nondiabetics. The rate of fatigue during cycle ergometer exercise for insulin-dependent diabetics may be predictable, and this may be important in evaluating exercise tolerance for these patients.
Seed priming with different levels and sources of zinc on the seed germination and seedling growth of barnyard millet (Echinocola frumentacea)

Field: Agricultural and Biological Sciences (Life Sciences)

Seed priming with zinc increases the seed germination and seedling growth of many crops. The present study aimed to investigate the effect of seed priming with different levels and sources of zinc on seed germination and seedling growth of barnyard millet variety MDU1. A germination experiment was conducted with various Zn sources and concentrations viz., T1- Non-primed seeds (control); T2-water priming; T3-GA3 priming; T4-T6: seed priming with 0.10%, 0.25% & 0.50% ZnSO4 ; T7- T9: seed priming with 0.10%, 0.25% & 0.50% Zn EDTA; T10-T12: seed priming with 0.10%, 0.25% & 0.50% Zn citrate and the experimental design was a completely randomized design (CRD) which were replicated five times. The seeds of MDU1 variety were treated with different sources and levels of Zn for 12h and the seed germination study was carried out for 15 days. After 15 days, the germination percentage, speed of germination, germination energy, germination index and the seedling growth parameters such as, root length, shoot length, vigour index and seedling dry weight were recorded. Seed priming with 0.50% ZnSO4 performed better in increasing the germination percentage (99%), speed of germination (76.2%), germination energy (69.4%), germination index (3.91) and seedlings growth parameters like shoot length (14.7cm), root length (16.5cm), seedlings dry weight (0.44g), vigour index I (3099) and II (44.6), Zn content (21.9 mg kg-1) & its uptake (5.54 mg g-1). This was closely followed by seed priming of Zn EDTA at 0.25% and Zn citrate at 0.50%. From this study, it can be concluded that seed priming with 0.50% ZnSO4 could be used to improve the germination and seedling growth of barnyard millet which was also economical.
Research progress on the growth promoting effect of microbial fertilizer on plants

Field: Agricultural and Biological Sciences (Life Sciences)

Microbial fertilizer is a kind of live bacteria preparation that can make plants obtain specific fertilizer effect. With the extensive use of chemical fertilizers and pesticides caused by a series of problems, people began to pay more and more attention to the research and use of microbial fertilizer. This paper describes the application of microbial fertilizer in food crops, vegetables, fruit trees and so on. The mechanism of microbial fertilizer was explained from five aspects: improving soil fertility, promoting plant growth, biological control, improving plant product quality and improving environmental conditions.
Reading the criticism : Georgette Heyer's and the romance novel's (mis) fortune

Field: Arts and Humanities (Social Sciences)

‘Romance novels’ são populares desde o seu surgimento; Orgulho e Preconceito é um dos livros mais famosos do mundo – se não o mais famoso – e uma longa lista de obras canônicas podem ser inclusas nesta categoria. A Harlequin Book por si só publica mais de 110 títulos em 34 línguas a cada mês e o site da organização Romance Writers of America afirma que o gênero teve volume de vendas de 1,08 milhões de dólares somente em 2013¹. Seria de ser esperar que um gênero literário tão prolífico, popular e lucrativo teria um vasto estudo crítico – este não é o caso. As ‘romance novels’ vem sendo marginalizadas há bastante tempo, feministas e outros críticos não poupam esforços quando se trata de atacar e culpar o gênero pelo o que eles chamam de ‘servidão’ feminina no patriarcado e de diminuir o mesmo a um passatempo descerebrado e trivial para mulheres enquanto esperam a roupa lavar. A maior parte dos estudos críticos a respeito do gênero foram escritos na década de oitenta e no começo da década de noventa. A obra de Janice Radway - intitulada Reading the Romance: Women, Patriarchy, and Popular Literature – mostra um estudo conduzido com um grupo específico de leitoras de um subgênero específico de romance. Deste subgênero foram selecionadas vinte obras que são então usadas para apresentar conclusões sobre todo o gênero de ‘romance novels’. Se a crítica do gênero em si é escassa, a crítica de autoras em específico é ainda mais difícil. Georgette Heyer foi a precursora do subgênero ‘Regency romance novels’ e umas das escritoras britânicas mais populares. Ela escreveu mais de cinquenta romances e mais de quinze contos, além disso, costumava vender, pelo menos, dez mil cópias de cada obra lançada (KLOESTER; 2011). Apesar de tudo isso, estudos críticos da sua obra são raros. Em contraponto a este cenário, este trabalho propõe uma retrospectiva da crítica sobre o gênero com foco na produção da escritora Georgette Heyer. A teoria proposta aqui é que a falta de crítica em torno do gênero – costumeiramente atribuída à falta de qualidade do produto – pode, possivelmente, estar relacionada ao uso inadequado de ferramentas e teorias de estudo literário. Estudos e visões mais recentes sobre o gênero são apresentadas como contraponto e atualizações da primeira onda de estudos críticos sobre o gênero, bem como uma atualização da forma como a relação entre a leitora e o ‘romance novel’ é vista.
Evaluation of experimental plot design for a sloping and eroding site

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Sloping and eroding soils are often avoided by many agronomists when selecting a site for long term crop or soils research due to concerns about the impact of soil variability on experimental results. The extent of soil loss and erosion phase was determined by comparisons of soil properties at the cultivated site with a forest site having similar soil, slope and landscape characteristics. The cultivated site was dominated by the moderately eroded phase of the Grantsburg soil with approximately 7.5 cm of soil (38% of upper 20 cm of original soil) eroded during the previous 80 years. Prior to the establishment of the tillage treatments of no‐tillage (NT); chisel‐plow (CP); and moldboard plow (MP), a number of selected soil property parameters were examined to measure the inherent soil conditions that existed within the experimental area, and to test the precision of the experimental design. An experimental design was selected which fit within the field boundaries, landscape position, soil and slope constraints. The experimental design was a Youden Type III, and Incomplete Latin Square, that allowed for randomization of treatments to the plots by both row (block) and column (replication) to control random variability in the two directions. Overall, the experimental design selected to control random variability that existed within the experimental area was effective. This was evidenced by the lack of significant differences among most of the tillage treatment locations with respect to the background data collected. Notes Funded as part of Hatch Project No. 15–359 and in cooperation with Northcentral Regional Project No. NC‐174. Published with the approval of the Director, Illinois Agricultural Experiment Station, Urbana, IL. Corresponding Author. Egerton, Njora, Kenya.
ACUTE FULMINATING LARYNGOTRACHEOBRONCHITIS IN AN ADULT

Field: Medicine (Health Sciences)

Acute fulminating laryngotracheobronchitis in children has been described by various writers. There is, however, a great paucity of literature concerning this condition in adults. The disease is usually seen in children from several months to about 9 years of age, the most frequent incidence being between 2 and 4 years. It is an extremely serious condition, owing to the obstruction of the respiratory tract by the swelling of the mucous membrane lining the trachea and bronchi and, lying on this swollen mucous membrane, a sticky, gummy exudate or secretion, which in turn causes more obstruction. The typical case history is as follows: The child awakens at night with symptoms resembling those of spasmodic croup, with inspiratory dyspnea and hoarseness. Fever is usually present. Remedies such as those administered in cases of croup have practically no effect on the respiratory difficulty, and one thinks of diphtheria, or possibly a foreign body
A Computational Investigation on the Blade Profile of Vertical Axis Fluid Turbine with Movable Double Streamline Vane

Field: Engineering (Physical Sciences)

The computational investigation on the blade profile of the movable vanes at various angle of attack was used to obtain the shape of the vanes. The SIMPLE algorithm, the standard k-É› model, and the near-wall treatment were used to do computation. This method successfully obtained the flow fields of the blades, and the blade profile could be modified based on the flow fields.
Adsorption of Three Flavonoids from Aqueous Solutions onto Mesoporous Carbon

Field: Chemistry (Physical Sciences)

A mesoporous carbon adsorbent was synthesized for the adsorption of myricetrin, puerarin, and naringin from aqueous solutions. The mesoporous carbon can effectively adsorb the flavonoids, and the adsorption capacities at the feed temperature of 298 K and equilibrium concentration of 0.05 mg·mL–1 were from 63 to 206 mg·g–1. Adsorption thermodynamic parameters were calculated. Adsorption kinetics and adsorption dynamic breakthrough experiments further confirmed the efficient adsorption of these molecules on the carbon adsorbent. A complex mechanism involving physical adsorption and chemical adsorption was suggested for the adsorption of myricetrin, puerarin, and naringin on the mesoporous carbon.
Development of sweet pepper F1 hybrids based on MAS methods by fruit quality and resistance genes

Field: Agricultural and Biological Sciences (Life Sciences)

This work aims to assess the developed, using MAC methods, F 1 hybrids and parent forms of sweet pepper by fruit quality (Ccs, cl, norc) and pathogen resistant genes (Me1, pm) by a complex of biochemical (dry matter, carotene, vitamin C, soluble carbohydrates) and biometric (fruit mass, fruit wall thickness; early, commercial and gross yield) fruit characters and study the peculiarities of the characters' manifestation in F 1 hybrids.As an experimental material, 9 parental forms and 16 F 1 hybrids of sweet pepper were studied (crossing schemes 8×1 and 1×8).The features of the characters' manifestation in hybrids were evaluated during the period of three years (2016-2018) by the value of true heterosis and degree of dominance.As a standard, Troika pepper variety was used.Based on the three-year test results, valuable F 1 hybrids were identified (L45-11 × Shokoladnaya krasavitsa, L45-11 × Zhelty buket, L45-11 × L140/0, L140/0 × L45-11) characterized by the dry matter content at the level of 8.18-8.77%; carotene -19.95-32.73mg/kg; vitamin C -112.49-144.4mg/kg; soluble carbohydrates -4.36-4.77%.Three best hybrid combinations with a complex of biometric features were selected: L45-11 × Shokoladnaya krasavitsa, L140/0 × L45-11 and L45-11 × L160-10 characterized by the fruit mass at the level of 136.6-175.4g; fruit wall thickness -6.8-7.5 mm; early yield -0.68-0.77kg/m 2 ; commercial yield -4.16-4.97kg/m 2 ; and gross yield -4.27-5.01kg/m 2 .Analysis of the true heterosis manifestation in hybrids revealed its multidirectionality depending on the conditions of the vegetation period by the majority of the studied characters.The most frequent manifestation of the values of yield, mass, and carbohydrate content was the dominance and overdominance in the direction of the increased characters.The thickness of the fruit pericarpium manifested by theintermediate inheritance type -overdominance in the direction of decreased characters.