jimnoneill/paper-to-field-training huggingface dataset:
Marine clay as construction material

Field: Engineering (Physical Sciences)

The feasibility of using Marine Clay and Marine Clay – Copper Slag mixture as aggregates replacement in concrete were explored in this project. The feasibility of such replacement is dependent on the workability and strength properties of the concrete which will be determined through the slump and compression strength tests conducted on the different sets of specimens. The project is divided into two segments with the first segment investigating the feasibility of using of marine clay as a fine and coarse aggregate to replace sand and granite respectively in concrete production. The second segment is a joint experiment with another group, investigating the feasibility of using marine clay – copper slag mixture as a coarse aggregate to replace granite in concrete production. The report will only contain Methodology, Experimental Results, Results Discussion and Recommendations for Future Work regarding the second segment of the experiment.
Association between PIK3CA mutations and disease-free survival in patients with HR+, HER2- tumors treated with adjuvant hormonal therapy: A real-world study in Croatia.

Field: Medicine (Health Sciences)

e12512 Background: Disease recurrence of early hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast tumor subtype is particularly challenging to manage due to its complex and very heterogeneous biological nature. Namely, due to primary and secondary resistance, one-quarter of patients with early disease will present with the disease recurrence. This variability in the timing of recurrence highlights the need to better identify key biomarkers that could predict therapeutic outcomes and guide personalized treatment strategies for these patients. Mutations in the phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene have a high prevalence of 30% to 40% in HR+/HER2- advanced breast cancer. They lead to activation of the PI3K/AKT/mTOR pathway, promoting cell growth, and proliferation, and are associated with poor prognosis in advanced breast cancer. Our aim was to examine this association and impact of PIK3CA mutation status on disease free survival (DFS) in HR+/ HER2- early breast cancer patients. Methods: We conducted a multicentric, retrospective cohort study in five Croatian institutions from July 2020 to December 2021. Study included initially early HR+/HER2- breast cancer patients who have been diagnosed with disease recurrence during adjuvant hormonal treatment or within first six years of follow up. The Cobas PIK3CA Mutation Testing Kit was used for real-time PCR-based amplification and mutation detection on the Cobas z 480 analyzer. We have analyzed differences in DFS from initiation of adjuvant endocrine therapy, using Cox, proportional hazard regression. Results: There was total of 186 patients, out of which 40.9% tested positive for the PIK3CA mutation. Primary and adjuvant treatment and in particular adjuvant endocrine treatment was similar between the two groups. After adjustment for 14 relevant covariates, we found that patients with positive PIK3CA status and with H1047 PIK3CA mutation had significantly lower hazard for disease recurrence in comparison to patients with no PIK3CA mutation (HR 0.65; 95% CI 0.45; 0.95; p = 0.024; HR 6.52; 95% CI 1.15; 36.95; p = 0.034 respectively; false discovery rate, FDR < 10%) and higher odds for late recurrence (p = 0.001, FDR < 5%). Conclusions: This study highlights the potential impact of PIK3CA mutations on disease recurrence during/following adjuvant endocrine treatment and by that potentially opens the door for further investigation of possibly more personalized treatment strategies.
Using Fun English Learning for Trauma Healing of The Earthquakes: A Quasi-Experimental Study of the 10th grade students at SMAN 1 Gunungsari.

Field: Psychology (Social Sciences)

This research aimed to heal the 10 grade students‘ trauma of the
earthquakes by using Fun English Learning. This research was conducted by
using pseudo quasi experimental method. The subject of this research was X MIA
2 of SMAN 1 Gunungsari 2018/2019 academic year which consisted of 22
students. The objective of this research as to heal the 10th
grade students‘ trauma
of the earthquakes by using Fun English Learning at SMAN 1 Gunungsari. The
data of this research were gathered through quantitative and qualitative data.
The result of this research showed that there was decreasing of students‘
pre to post treatments questionnaire score. The mean of pre-treatment
questionnaire was 46,82 and the mean score of the post-treatment is 25,77. That
means the trauma score of the students‘ decrease. There are 95, 5% (21 students)
whose healed and 4,5% (1 student) whose unhealed or still have acute stress
disorder. In the other words, the Fun English Learning was not worked effectively
to heal the trauma of the students, but showed a good result, from 22 students only
1 student who still have ASD.
Buruli ulcer in West Africa: Aspects of patient management

Field: Medicine (Health Sciences)

Buruli ulcer is a tropical infection caused by Mycobacterium ulcerans. Typically, a large skin ulcer appears which is initially painless, but heals slowly. A common problem is that patients come to the hospital at an advanced stage, increasing the risk of serious scarring and contractures, leading to functional limitations. Previously, treatment for Buruli ulcer revolved around surgery followed by prolonged hospitalization, but during the last decade, an antibiotic regimen has become available, consisting of 8 weeks of daily rifampicin tablets and streptomycin injections – which is still long and painful. We have now shown that prolonged streptomycin administration also leads to irreversible hearing loss. We have also shown that for a subset of patients with small lesions, a reduction in treatment duration might be feasible. To ensure that patients come to the hospital with early, small lesions, we show that programs aimed at early detection are feasible. Trained community volunteers from endemic villages appear pivotal, resulting in significant impact on referral at an early stage, with excellent recovery resulting in high, unimpaired quality of life. We also studied wound care in endemic areas, and show that there is room for improvement, both through cheap and simple measures, and the introduction of modern wound dressings. Once a neglected condition leaving half of patients with considerable disability and prolonged severe suffering, Buruli ulcer – though still a Neglected Tropical Disease – has changed into a condition for which effective standardized therapy is available, provided that programs are in place to encourage patients to report early.
Classification analysis using hidden Markov model

Field: Mathematics (Physical Sciences)

A hidden Markov model (HMM) provides useful representations of dependent heterogeneous phenomena. So it becomes a popular method for modelling stochastic processes and time-dependent sequences, and is primarily applied in many different fields such as language, handwriting recognition, and molecular biology. Especially, in the sequence classification case, classification among known hidden Markov models is known to be accomplished with a classifier that minimizes the probability of error. In this paper, we first generate variables for the hidden state using the hidden markov model and then analyze the state using various classification methods. It differs from the existing analysis method by using the state variable and the mixture distribution based on the state rather than using the observed value directly in the analysis. In addition, it can be used to identify the relevance in the underlying process. As as illustration, we used the annual production of Matsutake mushroom data observed in five regions from 1997 to 2016.
A Multilevel Framework for Effective Interagency Collaboration in Mental Health

Field: Health Professions (Health Sciences)

The difficulty of coordinating service provision in interagency programs is a challenge for many working in public policy. We reflect on lessons learned through evaluating two inter‐agency supported housing programs for people with mental illness and propose a framework outlining components needed for well co‐ordinated service provision. We specify collaborative mechanisms at the policy, agency, service and client level. The key component is the role of an ‘integration coordinator': a person who is able to facilitate relationships and ensure effective information flows. Relationships need to be actively maintained to meet the inevitable challenges that will arise in complex interagency systems. The framework is relevant to policymakers across the public sector, including mental health, drug and alcohol, aged care, and policing .
Incorporation of 5‐lododeoxyuridine into the DNA of mouse embryos: Its relation to embryotoxicity

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Pregnant female ICR mice were administered, ip, either a trace (200 μCi/kg) or teratogenic (200 μCi + 300 mg/kg) dose of [6‐ 3 H] 5‐iododeoxyuridine (IdU) on day 10 of gestation. Maternal liver, spleen, intestine, and kidneys, and placentas and embryos were removed at various time intervals after injection, weighed, and homogenized in cold 0.5 M perchloric acid. The half lives of IdU‐derived nucleotides in the acid‐soluble fraction ranged from 31–46 min (trace) to 57–131 min (teratogenic) for the tissues analyzed. [ 3 H] IdU was incorporated into the DNA of all mitotically active tissues after both dosages. The presence of the label in iodouracil was demonstrated by thin‐layer chrornatography of DNA bases extracted from maternal spleen and embryo. Growth of embryos following injection on day 10 resulted in decreased 3 H‐specific activity in the DNA fraction and concomitant retention of total activity. It is suggested that the previously demonstrated embryotoxicity of IdU is related to its retention at its presumed intracellular site of action.
Modified Successive Approximations Method for Solving Fuzzy Second Kind Fredholm Integral Equations with Separable Kernel

Field: Mathematics (Physical Sciences)

This paper presents an analysis, development, and application of a modified method of successive approximations to solve fuzzy second kind Fredholm integral equations with a separable kernel. The fuzziness in the equations is represented utilizing convex normalized triangular fuzzy numbers, which are based on a single and double parametric form of fuzzy numbers. In the single parametric form of the fuzzy number, a fuzzy equation converts to two crisp equations for the solution which increases the computational cost. Therefore, to reduce the computational cost and increase the solution's accuracy, the double parametric form of the fuzzy number will be used in this study. The feasibility of the proposed methods is illustrated through a numerical example. The results obtained using the presented approach demonstrate adequate agreement with relevant theoretical aspects.
Viral Diseases of the Fetus and Newborn

Field: Medicine (Health Sciences)

The response of fetus or neonate to various insults—both infectious and chemical—is limited, and persons responsible for medical management during the development and early nurture of these delicate creatures must have ready information to guide care. Unfortunately, these problems bridge the artificial interface in the usual medical care scheme between obstetrics and pediatrics. The attention and expertise of both clinical specialities must be coordinated for recognition and management of these insults and only joint efforts will provide any long-term solutions.Viral Diseases of the Fetus and Newbornprovides a comprehensive description of the major perinatal virus infections. The authors are qualified by long experience and investigations in this field, and the volume is well illustrated and well referenced. The chapter on rubella chronicles the history of recognition of the teratogenetic effect of intrauterine infection as well as the methods for isolation of the virus, description of the varied clinical manifestations,
Solution of an Insight Problem at Different Age Levels

Field: Psychology (Social Sciences)

The purpose was to study performance on an insight problem by 3-to 25-yr.-olds. A task involving restructuring and requiring two wooden blocks be fitted together to form a tetrahedron was presented to five groups of 20 subjects each from kindergarten, primary school, secondary school, high school, and a university. The frequencies of solvers within each group increased from the first age group to the third but then remained constant. Solution times and frequencies of solutions attempted were not significantly different among the five groups. Perhaps insight does not follow the same developmental trend as other thinking processes.
Intangible cultural heritage research in China from the perspective of intellectual property rights based on bibliometrics and knowledge mapping

Field: Social Sciences (Social Sciences)

Abstract This research scrutinizes the trends and dynamics of Intellectual Property Protection (IPP) of Intangible Cultural Heritage (ICH) in China, utilizing a dataset of 91 papers from the CNKI database spanning 2011 to 2020. The study uses CiteSpace software to visualise and analyse the literature across multiple dimensions, including article count, authorship, institutional affiliations, and keyword co-occurrence. Findings indicate a lack of robust collaboration among authors and institutions in IPP and ICH, with a scarcity of active cooperative groups. Critical research hotspots identified encompass intangible cultural heritage, intellectual property protection, inheritors, legal protection, copyright, intellectual property law, and geographical indications, with the legal safeguarding of ICH’s intellectual property, digital conservation, traditional cultural expressions, and original authentication emerging as the leading research frontiers. This investigation provides a holistic view of China’s IPP and ICH landscape, offering essential scientific insights for ongoing scholarly discourse. This study mainly benefits policymakers and stakeholders in the cultural heritage sector, underscoring the necessity of enhanced authorial and institutional collaboration and the prioritization of legal and digital protection mechanisms to safeguard China’s intangible cultural legacy for posterity. The analysis is critical, informing policy formulation and strategic planning to bolster ICH’s protection and sustainable management in China.
Appreciation of electronics through engineering suites

Field: Computer Science (Physical Sciences)

Modern technology has been created variety of electronic product to enhance our daily lives. Nowadays even children and teenagers tend to use electronic product like a fish to water. And it’s time to think how to guide and let them have the interest to learn electronics instead of just using it. Let children to learn programming which help on children’s capacity of independent thinking. As more and more people notices on the value of the programming, some Western European countries even prepared to programming classes as primary and secondary schools compulsory. But only writing program will make beginners feel bored, if combines with some hardware devices work together to make some cool feedback, and then be able to attract more young people. Arduino is a great start kit for youth creativity and innovation platform which is an open-source electronics prototyping and wrap the messy details of microcontroller programming into an easy to use package.In this final Year Project, Arduino is introduced and shows how to set up the hardware, software and upload the sketch. There are several mini projects are create using Arduino which could be use at “Arduino Workshop” to bring Arduino and Electronics to youth. Student be having on-hands training for those developed mini project. And get familiar with the Arduino platform and gain the basic knowledge of programming after the workshop.
Expanding the Case for School Choice

Field: Social Sciences (Social Sciences)

Abstract This chapter situates the book's empirical findings within broader education-policy debates about school-choice programs, such as vouchers or tax credits, that enable students to spend public funds to attend private schools. Debates about school choice usually focus on the educational consequences of these programs, especially their effects on student outcomes and on public schools. The findings presented in this book offer an additional, and novel, justification for supporting school choice: In addition to providing urban residents with access to Catholic schools with a proven track record of educating disadvantaged students, however, school choice might also stem the tide of Catholic school closures, thereby preserving critical urban neighborhood institutions. Since charter schools do not appear to have the same positive effects as Catholic schools, this evidence also provides a partial answer to the common perception that charter school programs provide sufficient educational options and thus more-expansive school choice is unnecessary.
Selenium induces a multi-targeted cell death process in addition to ROS formation

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Selenium compounds inhibit neoplastic growth. Redox active selenium compounds are evolving as promising chemotherapeutic agents through tumour selectivity and multi-target response, which are of great benefit in preventing development of drug resistance. Generation of reactive oxygen species is implicated in selenium-mediated cytotoxic effects on cancer cells. Recent findings indicate that activation of diverse intracel-lular signalling leading to cell death depends on the chemical form of selenium applied and/or cell line investigated. In the present study, we aimed at deciphering different modes of cell death in a single cell line (HeLa) upon treatment with three redox active selenium compounds (sele-nite, selenodiglutathione and seleno-DL-cystine). Both selenite and selenodiglutathione exhibited equipotent toxicity (IC50 5 lM) in these cells with striking differences in toxicity mechanisms. Morphological and molecular alterations provided evidence of necroptosis-like cell death in sel-enite treatment, whereas selenodiglutathione induced apoptosis-like cell death. We demonstrate that selenodiglutathione efficiently glutathiony-lated free protein thiols, which might explain the early differences in cytotoxic effects induced by selenite and selenodiglutathione. In contrast, seleno-DL-cystine treatment at an IC50 concentration of 100 lM induced morphologically two distinct different types of cell death, one with apoptosis-like phenotype, while the other was reminiscent of paraptosis-like cell death, characterized by induction of unfolded protein response, ER-stress and occurrence of large cytoplasmic vacuoles. Collectively, the current results underline the diverse cytotoxic effects and variable potential of redox active selenium compounds on the survival of HeLa cells and thereby substantiate the potential of chemical species-specific
10. The scrolls and early Christianity

Field: Arts and Humanities (Social Sciences)

Abstract ‘The scrolls and early Christianity’ looks at what the Dead Sea Scrolls can tell us about Christianity. Any link between the Dead Sea Scrolls and the Catholic Church generates a great deal of sensationalism. Some say that the scrolls are New Testament documents that depict Jesus. For instance, one fragment apparently tells of a ‘slain prince [or messiah]’. In fact, the prince was actually slaying someone else — oddities in vowel and suffix use in ancient Hebrew give rise to the misinterpretation. Another theory suggests that there was a common sectarian matrix in use at the birth of Christianity, meaning that one sect could use words very differently to another.
Imagery,Conception and Illustrating Pictures of Chinese Traditional Poetry Translation

Field: Arts and Humanities (Social Sciences)

Chinese traditional poetry should be the highlight of Chinese culture with its unique beauty of imagery and conception.However,affected by the distinctions of linguistic signs and the inter-cultural cognition gap between the East and the West,Chinese traditional poetry always lose some of their poetic beauty after being decoded.From the semiotic perspective,auxiliary functions of illustrating pictures of Chinese traditional poetry translation would help better deliver the poetic beauty of imagery and conception to target language readers.
USING EMOTIONAL INTELLIGENCE COACHING TO HELP COLLEGE STUDENTS SUCCEED

Field: Arts and Humanities (Social Sciences)

Appears in: ICERI2019 Proceedings Publication year: 2019Page: 646ISBN: 978-84-09-14755-7ISSN: 2340-1095doi: 10.21125/iceri.2019.0208Conference name: 12th annual International Conference of Education, Research and InnovationDates: 11-13 November, 2019Location: Seville, Spain
Effect of Age on the Lysine and Sulfur Amino Acid Requirement of Growing Chickens

Field: Agricultural and Biological Sciences (Life Sciences)

Several 14-day growth assays were conducted to determine the dietary lysine and sulfur amino acid (SAA) requirement of the chick during the periods 14 to 28 days and 41 to 56 days posthatching. A sesame meal-gelatin diet supplemented with essential amino acids but limiting in both lysine and SAA and containing 3200 kcal. M.E./kg. was fed at 23% and 20% protein during the 14- to 28-day and 42- to 56-day periods, respectively. The lysine requirement for maximal growth rate was found to be a constant (4.62) percent of the protein with increasing age. The SAA requirement expressed as a percent of the protein, however, decreased from 3.05 ± 0.07% during the third and fourth week to 2.56 ± 0.15% during the seventh and eighth week of the chick’s life.
Nature of Cosmic-Ray Particles

Field: Physics and Astronomy (Physical Sciences)

The first section of this report contains a brief summary of those experiments which have made substantial contributions to our knowledge of the nature and mode of absorption of cosmic-ray particles. Included is a discussion of the difficulties which inhere in the attempts to interpret the observed cosmic-ray phenomena in terms of the assumption that the cosmic-ray particles are practically all protons and positive and negative electrons. These difficulties are resolved by demonstrating that in the same momentum range there exist two types of particles, one of which is highly absorbed in a heavy material, mostly through radiation, while the other is relatively penetrating. Behavior of the first kind is typical of shower particles in general, and of all single negatron secondaries, which are presumably produced in elastic collisions with atomic electrons. This group is therefore to be identified with electrons. As it can be shown that particles of the penetrating group cannot be of protonic mass, it follows that they must be neither electrons nor protons. The simplest assumption is that their distinguishing property is a mass intermediate between the electron and proton. Confirmation of this view is found in the observation by other writers and by ourselves of particles whose range, ionization and curvature relations are such that they demand a mass in this region. The best range and ionization data seem to give mass determinations in the neighborhood of 200 electron masses. A discussion is given of certain difficulties which exist in the interpretation of cosmic-ray particles as electrons and mesotrons of a unique mass.