jimnoneill/paper-to-field-training huggingface dataset:
The Future of Indonesia for Sustainable Engineering and Innovation for Sustainability and Its Impact?

Field: Engineering (Physical Sciences)

On a list of the world's most populated nations, Indonesia comes in at number four.One of the nations with the largest populations is Indonesia.The population of Indonesia is 273 million.With so many human resources already in place, it goes without saying that there is a need for sustainable engineering development and innovation that have an influence on the economy of our nation.Due to its large population, Indonesia frequently experiences socioeconomic disparities such as hunger, poverty, and injustice.As a result, this essay makes future predictions for Indonesia.
The role of PPAR-γ antagonism on losartan ameliorating effect on lung injury and systemic inflammation induced by LPS in mice

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Anti-inflammatory effects have been shown for losartan and GW9662 (a PPARγ-selective antagonist). The effect of losartan and GW9662 alone or in combination on lipopolysaccharides (LPS)-induced lung injury and systemic inflammation were examined. Male BALB/c mice were intraperitoneally administered saline or LPS for seven days. Animals were treated with losartan or GW9662 or the combination of two drugs in both saline and LPS administered groups for three days before and during the saline or LPS injection (tn=7 in each group). In the LPS group, thiol, catalase (CAT) and superoxide dismutase (SOD) in the serum, and TGF-β1 and IFN-γ levels and INF-γ/IL-4 ratio in the BALF were decreased, but total and differential white blood cells (WBC) count in the blood and the BALF, and serum malondialdehyde (MDA) and BALF IL-4 levels as well as lung pathological changes were significantly increased compared to the control group (p<0.001 for all cases). Treatment of LPS group with losartan or combination of losartan+GW significantly improved most of those pathological changes compared to the LPS group (p<0.05-p<0.001), but treatment with GW alone did not change any variable. The results showed the preventive effect of losartan on LPS-induced lung injury and systemic inflammation which might be partially mediated through PPAR-γ-receptor
Application of a next-generation genetic analysis in the field of hemophilia

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

要約：血友病は血液凝固第VIII 因子遺伝子（F8），第IX 因子遺伝子（F9）中の多種多様な遺伝子変異によって引き起こされる．これまで患者の病因遺伝子変異の解析は，1）エクソンとその近傍のPCR 増幅とシークエンスによる点変異や小規模な欠失・挿入の検出，2）MLPA（Multiplex Ligation-dependent Probe Amplification）による大規模な欠失・挿入の検出，3）ロングPCR によるX染色体逆位の検出，が行われてきた．しかし近年，身近になった次世代シークエンス（NGS）がこれらの解析に取り入れられるようになってきた．折りしも血友病の医療は，個別化医療に向かいつつある．またゲノム編集による遺伝子治療も臨床応用に向けて着実な進歩をみせている．このような状況下，個々の患者の責任遺伝子を中心としたジェノタイプの把握にNGS 解析の活用が期待されている．
The Linear Combination of Logistic and Gumbel Random Variables

Field: Mathematics (Physical Sciences)

The exact distribution of the linear combination αX + βY is derived when X and Y are independent logistic and Gumbel random variables. A measure of entropy of the linear combination is investigated. Computer programs are provided for generating tabulations of the percentage points associated with the linear combination. The work is motivated by problems in automation, control, fuzzy sets, neurocomputing and other areas of computer science.
Low Adherence to Hepatocellular Carcinoma Surveillance Guidelines in Patients With Chronic Hepatitis B at a VA Medical Center

Field: Medicine (Health Sciences)

Introduction: Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer related deaths worldwide. Screening for HCC can detect early stage cancer and improve survival. Practice guidelines established by the American Association for the Study of Liver Diseases (AASLD) recommend HCC surveillance using abdominal ultrasound at six month intervals in high risk chronic hepatitis B patients and all patients with cirrhosis. We aimed to assess adherence to guidelines for HCC surveillance in patients with chronic hepatitis B at a VA Medical Center. Methods: In a single center retrospective analysis, adherence to HCC surveillance guidelines in high risk chronic hepatitis B patients from January 2009 till December 2014 was analyzed. Eligible hepatitis B patients included Asian males over age 40, Asian females over age 50, those with a family history of HCC, African/North American Blacks, and those with cirrhosis. The earliest positive test date recorded for hepatitis B viral testing was defined as the date of diagnosis. The dates of abdominal ultrasound and AFP tests were retrieved from chart review. Results: 89 eligible patients were identified. 84 (94.4%) were male and 5 (5.6%) were female. 82 (92.1%) were African Americans, 3 (3.4%) were Asians and 4 (4.5%) were Caucasians. The median follow-up time after July of 2010 (AASLD guideline update) for the 81 analyzable patients was 46.6 months (range 7.7 to 54.3). The median age was 51 (range 24-86). 24 (30%) patients had coexisting hepatitis C. The compliance rate, defined as the number of times abdominal ultrasound was performed divided by recommended ultrasound screening times, ranged from 0% to 75%. The rate of adherence to surveillance was 0% in 24 (29.6%) patients, 0-25% in 34 (42.0%) patients, 25-50% in 19 (23.5%) patients, and 50-75% in 4 (4.9%) patients. The overall compliance rate for the cohort was 21.2%. Although the use of AFP value alone is no longer recommended for HCC surveillance, AFP testing was performed 157 times in this cohort, compared with 105 times for abdominal ultrasound. Conclusion: The overall compliance rate to HCC surveillance in this study was 21%. The absence of clinical reminders for HCC surveillance in patients with chronic Hepatitis B at our institution could be a contributing factor. Increasing physician awareness and compliance rate to HCC surveillance is critical to early diagnosis and improved survival of HCC.
GOVERNMENT’S PERFORMANCE ON THE PUBLIC SERVICE REGARDING BUILDING PERMITS IN URBAN PLANNING OFFICE OF GORONTALO CITY

Field: Social Sciences (Social Sciences)

Abstract Government’s performance in the public service regarding building permit in Urban Planning Department of Gorontalo City. This research aims at investigating the public service performance at the Urban Planning Office of Gorontalo city. This qualitative descriptive research employed observation, interview, and documentation in collecting the data. The technique of data analysis comprised of data reduction, data display, and conclusion. The results reveal that the government’s performance is influenced by 1) human resources, 2) facilities and infrastructures, and 3) job mechanism. Furthermore, the efforts to improve the performance are 1) participation of the officers in technical training about building permits policy; 2) disseminating the insight regarding building permit on the district level through the media such as newspaper, television, and radio; 3) providing proper facilities and infrastructures. Efforts to improve the performance should include 1) upgrading human resources; 2) providing facilities and infrastructures; 3) coordinating with the local government unit; 4) promoting awareness of the society since some people do not have a properunderstanding of the legality of building permits. Keywords: Performance and Public Services
Is a Basis of Fact Discernible in the Miracle Story of the Healing of the Blind Man at Bethsaida (Mk viii. 22-26)?

Field: Arts and Humanities (Social Sciences)

Is a Basis of Fact Discernible in the Miracle Story of the Healing of the Blind Man at Bethsaida (Mk viii. 22-26)? was published in Studia Evangelica Vol. VII: Papers presented to the Fifth International Congress on Biblical Studies held at Oxford, 1973 on page 83.
Antibiotic Sensitivity of <i>Neisseria meningitidis</i> Isolated From Patients with Generalized Forms of Meningococcal Infection and From Healthy Carriers

Field: Immunology and Microbiology (Life Sciences)

The study included 50 isolates of Neisseria meningitidis isolated from patients with generalized forms of meningococcal infection and 48 isolates, which were isolated from carriers. The isolates were identified by MALDI-TOF mass spectrometry using a Microflex LT mass spectrometer (Bruker Daltonics, Germany). Minimum inhibitory concentrations (MICs) of benzylpenicillin, ampicillin, ceftriaxone, meropenem, ciprofloxacin, azithromycin, rifampicin, and chloramphenicol were assessed by the method of serial agar dilution with interpretation of the results according to EUCAST 2021 criteria. Clinical resistance to penicillin was detected in 7% of isolates. However, all isolates with MIC >0.064 µg/ml (n=26) had mutations in the penA gene. Decreased sensitivity to rifampicin was found in four isolates isolated from patients and four isolated from carriers. Seven out of eight isolates with reduced sensitivity to rifampicin had mutations in the rpoB gene. Resistance to ceftriaxone, meropenem, ciprofloxacin was not detected.
A kinetic study of solar wind electrons: Implications for a mission close to the sun

Field: Physics and Astronomy (Physical Sciences)

We have modelled the evolution of the electron velocity distribution function in high-speed solar wind streams, from the collision-dominated corona and into the collisionless interplanetary space. The model solves the kinetic transport equation, with the Fokker-Planck collision operator to describe Coulomb collisions between electrons. We use a test particle approach, where test electrons are injected into a background solar wind. The density, temperature and electric field associated with the background are obtained from a three-fluid solar wind model. The test electrons are in thermal equilibrium with the background at the base of the corona, and we study the evolution of the velocity distribution of the test electrons as a function of altitude. We find that the test particle distribution function is mainly determined by the electric field and the expanding geometry, and to a lesser extent by collisions. The distribution function consists of an almost isotropic, static core which is bound in the electrostatic potential, and a beam-like high-energy tail which escapes. Velocity filtration, due to the energy dependence of the Coulomb cross section, is not alone capable of producing significant beams in the distribution or a temperature moment that increases with altitude. The distribution function is in excellent agreement with the distribution functions observed by the Helios spacecraft in high-speed streams near the orbit of Mercury.
Severe Anaemia as A Predictor of Mortality in Heart Failure Patients

Field: Medicine (Health Sciences)

Introduction: Anaemia at the time of diagnosis of heart failure is said to be an independent factor for mortality during the following years. In this study, the effect of severe anaemia at the time of diagnosis, in the outcome of heart failure in the form of in hospital mortality is studied. Methods: One hundred eighty-four heart failure patients admitted in Manamohan Cardiothoraccic. Vascular and Transplant Centre between September 2011 to March 2012, age above 15 years were enrolled in the study. Baseline investigations and hemoglobin was done and the patients were followed up till discharge or in hospital mortality. Results: Among the 184 heart failure patients 115(62.5%) had anaemia. When evaluated in a bivariate model, the odds ratio of death for patients with mild anaemia compared with patients with no anaemia was 3.90.6-22.6, p value 0.124) for moderate anaemia 4.5 (0.9-23.07, p value 0.064) and for severe anaemia 46.06 (8.6-246.05, p value 1000), respectively. On multivariate analysis severe anaemia 919 (5.6-149762.9, p value 0.009) was still found to be a significant predictor of mortality Conclusion: Severe anaemia at the time of diagnosis of heart failure is an independent predictor of in hospital mortality
Anterior-to-posterior Protective Capabilities of the Spine Buddy® Jockey Vest Support Pad

Field: Health Professions (Health Sciences)

Background: The Spine Buddy® jockey vest support pad was developed to be added underneath an existing jockey vest, against the spine, to protect the torso of jockeys from being trampled by horses. Purpose: The purpose of this study was to determine the force absorptive properties of the additional pad added to a jockey vest through two experiments: a simulated model and a human model. Methods: The simulated model experiment involved dropping a 90-pound horse hoof simulator onto a force plate from a height of 12 inches under three different conditions at 10 repetitions per condition: 1) bare force plate, 2) anterior aspect of a standard jockey vest, and 3) posterior aspect of a jockey vest with the addition of the Spine Buddy® support pad. The human experiment involved dropping a significantly lighter and safer load, a 1.5-pound weight, onto the sternum of 14 male study participants laying supine on a force plate from a height of 24 inches. This occurred under the following conditions: 1) jockey vest with Spine Buddy® support pad, 2) jockey vest alone, and 3) no jockey vest. Outcome measures during all six conditions were peak force. Results: For the simulated experiment the additional support pad reduced peak force 28.1% more than with the jockey vest alone (p=0.010). In the human experiment the additional support pad reduced peak force 6.4% more than the jockey vest alone (p=0.380). Conclusion: Preliminarily, the results of this study demonstrate that the addition of an extra cushioned support pad to a jockey vest can add to the protective capabilities of the vest in an anterior-to-posterior direction.
Efficient CRISPR-mediated base editing in Agrobacterium spp.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Significance Agrobacteria are plant-pathogenic bacteria that can deliver DNA to plant cells as part of their infection strategy. This property has been used for decades to generate transgenic plants and, more recently, to deliver gene-editing reagents to plant cells. Notwithstanding their importance for research and industry, laboratory strains have not been improved much over the years and several aspects of Agrobacterium biology and pathogenesis remain poorly understood. Here, we developed a CRISPR-mediated base-editing approach to efficiently modify the genome of Agrobacterium . We show that single-nucleotide changes can be introduced at targeted positions in both the Agrobacterium tumefaciens and Agrobacterium rhizogenes genomes. Whole-genome analysis of edited strains revealed only a limited number of unintentional mutations.
Synthesis and study of Arginin-containing copper and chrome chelates

Field: Chemistry (Physical Sciences)

Synthesis conditions have been established and arginin (Arg)-containing copper and chrome chelate compounds with the following general formulas: CuArgn(CH3COO)2·mH2O and CrArgn(CH3COO)3·mH2O (where n =1÷3; m=2 or 4) have been synthesized. Synthesized chelates have been studied using a number of physical and chemical research methods. In particular, their composition has been established via trace element analysis, while the individuality has been identified through melting temperature measurement and diffractographic method. Through study of qualitative solubility in different solvents there has been established that chelates are highly soluble in water and poorly soluble in organic solvents. Using the conductometric research method there has been calculated a dissociation constant of chelate compounds-containing solutions. Based on the preliminary trial tests carried out in order to study the biological activity, there is expressed an opinion that entry of arginin-containing copper and chrome chelates into composition of combined feed premixes of egg-laying (oviparous) poultry has had a positive impact on egg-laying intensity and poultry survival rate. There is given an opinion on the expediency of basic test conduct in order to determine the optimum doses of arginin-containing copper and chrome chelate compounds for egg-laying birds.
Control of Cotton Pests with Low-Volume Insecticides Applied with a Low-Volume Mist Sprayer123

Field: Agricultural and Biological Sciences (Life Sciences)

Journal Article Control of Cotton Pests with Low-Volume Insecticides Applied with a Low-Volume Mist Sprayer Get access H. M. Taft, H. M. Taft Entomology Research Division, Agr. Res. Serv., USDA, Florence, South Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar A. R. Hopkins A. R. Hopkins Entomology Research Division, Agr. Res. Serv., USDA, Florence, South Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 60, Issue 2, 1 April 1967, Pages 608–610, https://doi.org/10.1093/jee/60.2.608 Published: 01 April 1967 Article history Accepted: 16 January 1967 Published: 01 April 1967
WS2 Nanotube-Embedded SiOC Fibermat Electrodes for Sodium-Ion Batteries

Field: Materials Science (Physical Sciences)

Layered transition metal dichalcogenides (TMDs) such as tungsten disulfide (WS2) are promising materials for a wide range of applications, including charge storage in batteries and supercapacitors. Nevertheless, TMD-based electrodes suffer from bottlenecks such as capacity fading at high current densities, voltage hysteresis during the conversion reaction, and polysulfide dissolution. To tame such adverse phenomena, we fabricate composites with WS2 nanotubes. Herein, we report on the superior electrochemical performance of ceramic composite fibers comprising WS2 nanotubes (WS2NTs) embedded in a chemically robust molecular polymer-derived ceramic matrix of silicon-oxycarbide (SiOC). Such a heterogeneous fiber structure was obtained via electrospinning of WS2NT/preceramic polymer solution followed by pyrolysis at elevated temperatures. The electrode capacity fading in WS2NTs was curbed by the synergistic effect between WS2NT and SiOC. As a result, the composite electrode exhibits high initial capacity of 454 mAh g-1 and the capacity retention approximately 2-3 times higher than that of the neat WS2NT electrode.
Novel Therapies in Melanoma

Field: Medicine (Health Sciences)

The incidence of cutaneous melanoma is on the rise worldwide despite increasing awareness and vigilance towards prevention by the lay public and health professionals. Melanoma is easily curable by surgical excision when detected early, but it is nearly incurable when discovered in its later stages owing to resistance to treatment. Unfortunately, treatment options traditionally used in melanoma have not shown a survival benefit. However, as the understanding of tumor biology and metastatic growth evolves, new therapeutic options for metastatic melanoma have shown impressive survival benefit. The blockade of cytotoxic T-lymphocyte antigen 4 (CTLA-4) by use of the monoclonal antibody, ipilimumab (Yervoy™, Bristol-Myers Squibb), produces favorable antitumor immune system responses and was recently approved by the US FDA for use in patients with advanced melanoma. In addition, targeting components of the MAPK pathway have also demonstrated survival advantage in patients with BRAF-mutated melanoma and vemurafenib (Zelboraf™, Plexxikon/Roche) was approved by the FDA in August 2011 for the first-line treatment of both metastatic and unresectable melanomas for patients whose tumors have V600E mutations in the BRAF gene.
Online Resource For Patients Certified To Use Medical Cannabis

Field: Health Professions (Health Sciences)

Background: In recent decades medical cannabis use has grown and continues to grow in Hawaii, nationally, and internationally; since 2017 it has been available from medical cannabis dispensaries for Hawaii patients (“329 Card” holders) certified by a qualified medical practitioner. The current practice is for a qualified primary care practitioner (APRN-Rx or MD) to facilitate access to medical cannabis for their patients, but these practitioners generally provide minimal or no education regarding mechanisms of action, methods of use, varieties, and how and where to obtain medical cannabis leaving these details to be researched by patients themselves or by the education provided by medical cannabis dispensary staff.Purpose: To implement and assess the benefit of an evidence-based quality improvement project, in the form of an educational website, for a target population of elderly (65-year-old and older) patients to help them understand and better utilize and access medical cannabis. Methods: Project outcomes were measured via a short patient satisfaction survey with 2 biographic and 3 satisfaction rating questions plus 1 open-ended question linked to a website containing a range of information on topics related to medical cannabis use in Hawaii. Results: A total of 4 (n = 4) patients responded to the survey, 2 men and 1 woman between ages 50 and 64, and 1 woman between ages 35 and 49. A mean grade of 4.7 out of 5 “stars” was the aggregate satisfaction rating from the 3 quantifiable survey questions. Conclusion: The results suggest that a medical cannabis educational website could be beneficial to patients new to medical cannabis. While the results from the survey warrant furthur investigation of this or similar educational interventions for new to medical cannabis patients, due to the small sample size and lack of survey respondents in the target age range this project’s results are not transferable or translatable to larger populations.
[Method of isolation of cancer-associated and cancer-specific antigens].

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Several biological and biochemical techniques are combined to get the isolation of tumor-specific and tumor-associated antigens (TSA and TAA). Specific antisera to plasma membrane TSA and TAA from the mouse Ehrlich ascites cancer (EAC) cells are induced by selective immunization of immunologic chimera rabbits to normal mouse antigens. The specific anti-cancer immunosera are absorbed with normal antigens to remove any possible residual normal antigens. The antibodies to TSA and TAA are purified by several cycles of discontinuous ascending chromatography in dextran gel particles, and used as a ligand for affinity chromatography in cyanide bromide-activated agarose gel. The material offered to the column consists of EAC cell plasma membrane fragments solubilized by ultrasonic waves, and isolated by discontinuous sucrose density gradient centrifugation. The marked cytotoxicity inhibition of antisera to EAC cells obtained by the TSA and TAA eluted from the affinity chromatography column, and the great immunogenicity of TSA and TAA in EAC-bearing animals show the existence of potent specific rejection antigens (TSRA and TARA) among the obtained TSA and TAA. The amount of TSA and TAA isolated from the EAC cell plasma membrane is 6 ng/10(6) cells, representing 1 part per 43,000 of the cell proteins.
Human-Centric Telework and Sustainable Well-Being: Evidence from Peru’s Public Sector

Field: Social Sciences (Social Sciences)

This study examines the relationships among telework, job satisfaction, and quality of work life among employees in the Peruvian public sector, specifically at the National University Pedro Ruiz Gallo in Lambayeque. Using a quantitative approach with an explanatory scope and a nonexperimental cross-sectional design, data were collected from 194 employees through a structured questionnaire. Structural equation modeling (SEM) was employed to analyze the relationships between variables. The results reveal a positive impact of telework on both job satisfaction (β = 0.389, p < 0.001) and quality of work life (β = 0.323, p < 0.001). Job satisfaction was found to mediate the relationship between telework and quality of work life (β = 0.425, p < 0.001). Additionally, years of work experience negatively moderated the relationship between telework and job satisfaction (β = −0.114, p = 0.017), whereas gender had a positive moderating effect (β = 0.275, p = 0.016). These findings contribute to the understanding of telework dynamics in the public sector and offer valuable insights for tailoring telework policies to maximize employee well-being and organizational effectiveness.