jimnoneill/paper-to-field-training huggingface dataset:
Magnetic record of deglaciation using FORC-PCA, sortable-silt grain size, and magnetic excursion at 26 ka, from the Rockall Trough (NE Atlantic)

Field: Earth and Planetary Sciences (Physical Sciences)

Core MD04-2822 from the Rockall Trough has apparent sedimentation rates of ~1 m/kyr during the last deglaciation (Termination I). Component magnetization directions indicate a magnetic excursion at 16.3 m depth in the core, corresponding to an age of 26.5 ka, implying an excursion duration of ~350 years. Across Termination I, the mean grain size of sortable silt implies reduced bottom-current velocity in the Younger Dryas and Heinrich Stadial (HS)-21A, and increased velocities during the Bølling-Allerød warm period. \nStandard bulk magnetic parameters imply ﬁning of magnetic grain size from the mid-Younger Dryas (~12 ka) until ~8 ka. First-order reversal curves (FORCs) were analyzed using ridge extraction to differentiate single domain (SD) from background (detrital) components. Principal component analysis (FORC-PCA) was then used to discriminate three end members corresponding to SD, pseudo-single domain (PSD), and multidomain (MD) magnetite. The ﬁning of bulk magnetic grain size from 12 to 8 ka is due to reduction in concentration of detrital (PSD 1 MD) magnetite, superimposed on a relatively uniform concentration of SD magnetite pro- \nduced by magnetotactic bacteria. The decrease in PSD1MD magnetite concentration from 12 to 8 ka is synchronized with increase in benthic d13C, and with major (~70 m) regional sea-level rise, and may therefore be related to detrital sources on the shelf that had reduced inﬂuence as sea level rose, and to bottom-water reorganization as Northern Source Water (NSW) replaced Southern Source Water (SSW).
Transfection of recombinant adeno-associated virus serotype 9 to mouse heart in vivo and the impact on cardiac function

Field: Medicine (Health Sciences)

objective To evaluate the transfection efficiency of recombinant adeno associated virus semtype 9 carrying enhanced green fluorescent protein(rAAV9-eGFP)to mouse heart in vivo and the impact on cardiac function.Methods Sixteen Kunming(KM)mice were transfected rAAV9-eGFP by tail injection.eGFP expression in the heart,liver,lung,kidney and brain cryosections Was observed under inverted fluorescence microscope 7,14,21,28 days after the injection of rAAV9-eGFP and eGFP was quantitated by Western blot.Twenty KM mice were divided into control group and rAAV9-eGFP group randomly.and were received with saline or rAAV9-eGFP.The echocardiography and hemodynamics were performed 28 days after the injection of saline or rAAV9-eGFP.Results eGFP expression in the heart reached the maximum at day 21.at the point of which the transduction efficiency of rAAV9-eGFP in myocardium Was 32%.The other tissues had a little or no eGFP expression.The cardiac funetion did not reveal significant difference between rAAV9-eGFP group and the control group after transfection(P>0.05).Conclusion rAAV9-eGFP gene can be stably and efficiently expressed in mouse heart,and has no toxic efflect on cardiac function.

Key words:
Adeno-associated virus serotype 9; Green fluorescent protein; Transfection; Cardiac funotion
Early Detection of Gambling Among At-Risk Adolescents. Validation of EDGAR-A Scale

Field: Psychology (Social Sciences)

Despite the fact that minors have prohibited access to commercial gambling, and legislation trying to constrain gambling, an important proportion declares that they have bet either online, or by illegally entering gambling venues. This situation highlights the need to implement selective prevention programs that requires assessment tools to identify vulnerable groups. This paper aims to design and validate a scale of evaluation for the psycho-social characteristics that predict onset and maintenance of gambling behavior among adolescents. 2,716 students of Secondary Education, 15.12 years (± 1.03) answered a frequency, intensity and problematic gambling questionnaire and a scale to evaluate risk profiles. The resulting scale is compounded by 26 items classified in 4 sub-scales: Accessibility, Risk Perception, Normative Perception and Parental Attitudes. Internal consistency coefficients were: 0.668, 0.728, 0.746 and 0.818 respectively, and 0.811 for the total scale. Results offer a robust support on the structural validity and internal consistency of the Early Detection of Gambling among At-Risk Adolescents (EDGAR-A) Scale, a useful tool for the design and assessment of effective preventive interventions.
DESCRIBING KITAB PERUKUNAN BESAR MELAYU BY ABDUL RASYID BANJAR FROM THE LETTER OF ALPHABET CONCEPT TO SYNTHESIS CONSTRUCTION

Field: Arts and Humanities (Social Sciences)

As the spread of Islam in the archipelago, a manuscript found in 19th century AD entitled Perukunan Besar Melayu by Abdul Rasyid Banjar. It was about Fiqh which described using Bahasa and written in Arab-Melayu. So, it used as an object of research that categorized as a qualitative research with a philological descriptive approach. This study aims to describe 1) transliterated of the manuscript to obtain complete and clear editing, 2) compliances of spelled and punctuated, and 3) distribution of syntax. To achieve the research objectives, data analysis carried out using the philological work procedure techniques and comparative analysis. So, the result of this research is 1) transliterated of Arab-Melayu alphabet into Latin alphabet, 2) reconstruction of spelled and punctuated, and 3) syntactic reconstruction
Intrapleural Fibrinolytic Therapy for Complex Haemothorax in a Patient with Congenital Heart Disease and Eisenmenger Syndrome: A Case Report

Field: Medicine (Health Sciences)

Haemothorax, characterised by blood in the pleural cavity with a haematocrit greater than 50%, can arise from both traumatic and non traumatic causes. Prompt blood removal is crucial to prevent coagulation and complications like post-traumatic empyema. While tube thoracostomy is the initial management, Intrapleural Fibrinolytic Therapy (IPFT) offers a less invasive alternative when drainage is insufficient. The authors hereby, report the case of a 33-year-old male with congenital heart disease who presented with haemothorax. He exhibited worsening breathlessness, a cough with yellowish sputum and intermittent fever. Examination revealed clubbing, tachycardia, hypotension, tachypnoea and hypoxia. Imaging confirmed a right-sided pleural effusion with septations and severe Pulmonary Arterial Hypertension (PAH). Initial management with a pigtail catheter and antibiotics resulted in minimal drainage. The patient then underwent IPFT, leading to significant fluid drainage and radiological improvement. His clinical condition improved with reduced breathlessness and stabilised vital signs. The present case supports the efficacy of fibrinolytic agents like Streptokinase (STK) in managing clotted haemothorax, particularly in patients with complex medical backgrounds such as congenital heart disease. Early IPFT can enhance pleural drainage and reduce the need for invasive surgery, highlighting its value in similar clinical scenarios.
Effect of Cold Compress Therapy and Breastfeeding on Reducing Pain in Infants During Immunization (PCV) at Separi III Public Health Center

Field: Health Professions (Health Sciences)

In Indonesia, from from 2017 to 2021, there were 1,525,936 children Not yet get immunization base complete, at the Health Center Separi III coverage immunization base complete in 2023 is 83.4 % coverage low immunization is PCV with results baby who has do PCV 1 immunization 73.9%, PCV 2 62.6%. (Health Center Separi III, 2023) . Immunization is effort give immunity body to disease certain conditions, especially in vulnerable infants and children. to infection. Pain and anxiety moment immunization often become obstacle for parents for finish timetable immunization children they . Research This aiming For know influence combination therapy compress cold and breastfeeding decline pain in babies moment PCV immunization at the Community Health Center Separi III. Method: Study This use method quasi- experimental with posttest only non-equivalent control group design. Samples were taken in a way non probability sampling with total sampling technique, involving 34 babies who were divided into two groups. Group intervention accept therapy compress cold and breastfeeding, while group control only accept cotton Disinfection level high (DTT) according to procedure Health Center. Results: Research results show existence decline intensity pain in babies moment immunization from painful heavy become painful medium, light, even no painful the same once. Data analysis using Mann Whitney Test show p-value of 0.000 (p < 0.05), indicates that There is influence significant combination therapy compress cold and breastfeeding decline pain in babies moment PCV immunization. Conclusion and Suggestions: Combination therapy compress cold and effective breastfeeding in reduce intensity pain in babies moment PCV immunization, so that can become a recommended strategy in practice immunization For increase comfort and reduce anxiety in babies and parents.
Catching inflation by the tail - animal metaphoric imagery in the conceptualisation of INFLATION in English

Field: Arts and Humanities (Social Sciences)

ANIMAL metaphors are conventional in many languages and their metaphorical\nuse is not limited only to human beings, non-physical domains may also be\nunderstood in terms of the assumed properties of animals. Set within the wider\ntheoretical framework of Cognitive Theory of Metaphor, this paper deals with\nthe conceptualisation of INFLATION as an ANIMAL in English. We focus on\nthe INFLATION IS A FEROCIOUS ANIMAL metaphor, in which the most\nsalient properties of wild animals as a source domain are mapped onto the\nabstract and complex target domain, INFLATION, producing various\nconceptual mappings, which refer to the ways wild animals move, look, sound,\neat/are fed, attack and are controlled. We show how the INFLATION IS A\nFEROCIOUS ANIMAL metaphor functions within popular economic\ndiscourse, as well as how it structures our thinking about inflation, a dangerous\nphenomenon which poses a potential threat to every economy in the world.
Living on the Edge: Hawaii Hillside Development Regulation and an Exploitative Architectural Approach

Field: Engineering (Physical Sciences)

The hillsides and steep slopes of Hawaii present an array of complex design issues, hazards, and challenges to an architectural designer, the majority of which are obsolete or atypical in severity to those of a standard, non-sloping site. As such, governmental intervention has emerged, as well as the subsequent enforcement of site-specific regulations regarding the development of sloping terrain. Under these circumstances, a designer's approach must conform to the irregular terrain and its corresponding limitations, which will vary according to the degree of incline of the site. Prior to any inceptions of conceptual or schematic design, a clear and concise understanding of such regulations, their implications, and any other ensuing conditions and/or requirements is essential. Upon achievement of such qualifications, the challenge then posed, is the harmonious coalescence of program and place by exploitation of the site through the genius of architecture.
EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

EGF-R [EGF (epidermal growth factor) receptor] ligands can promote or inhibit cell growth. The biological outcome of receptor activation is dictated, at least in part, by ligand-specified patterns of endocytic trafficking. EGF-R trafficking downstream of the ligands EGF and TGF-α (transforming growth factor-α) has been investigated extensively. However, less is known about EGF-R fates induced by the ligands BTC (betacellulin) and AR (amphiregulin). We undertook comparative analyses to identify ligand-specific molecular events that regulate EGF-R trafficking and degradation. EGF (17 nM) and BTC (8.5 nM) induced significant EGF-R degradation, with or without ectopic expression of the ubiquitin ligase Cbl. Human recombinant AR (17 nM) failed to affect receptor degradation in either case. Notably, levels of ligand-induced EGF-R ubiquitination did not correlate strictly with receptor degradation. Dose–response experiments revealed that AR at a saturating concentration was a partial agonist at the EGF-R, with approx. 40% efficacy (relative to EGF) at inducing receptor tyrosine phosphorylation, ubiquitination and association with Cbl. EGF-R down-regulation and degradation also were compromised upon cell stimulation with AR (136 nM). These outcomes correlated with decreased degradation of the Cbl substrate and internalization inhibitor hSprouty2. Downstream of the hSprouty2 checkpoint in AR-stimulated cells, Cbl-free EGF-R was incorporated into endosomes from which Cbl–EGF-R complexes were excluded. Our results suggest that the AR-specific EGF-R fate results from decreased hSprouty2 degradation and reduced Cbl recruitment to underphosphorylated EGF-R, two effects that impair EGF-R trafficking to lysosomes.
Anti-inflammatory, antioxidant and renoprotective effects of SOCS1 mimetic peptide in the BTBR ob/ob mouse model of type 2 diabetes

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Introduction Diabetic nephropathy (DN) is the leading cause of chronic kidney disease worldwide. The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway participates in the development and progression of DN. Among the different mechanisms involved in JAK/STAT negative regulation, the family of suppressor of cytokine signaling (SOCS) proteins has been proposed as a new target for DN. Our aim was to evaluate the effect of SOCS1 mimetic peptide in a mouse model of obesity and type 2 diabetes (T2D) with progressive DN. Research design and methods Six-week-old BTBR (black and tan brachyuric) mice with the ob/ob (obese/obese) leptin-deficiency mutation were treated for 7 weeks with two different doses of active SOCS1 peptide (MiS1 2 and 4 µg/g body weight), using inactive mutant peptide (Mut 4 µg) and vehicle as control groups. At the end of the study, the animals were sacrificed to obtain blood, urine and kidney tissue for further analysis. Results Treatment of diabetic mice with active peptide significantly decreased urine albumin to creatinine ratio by up to 50%, reduced renal weight, glomerular and tubulointerstitial damage, and restored podocyte numbers. Kidneys from treated mice exhibited lower inflammatory infiltrate, proinflammatory gene expression and STAT activation. Concomitantly, active peptide administration modulated redox balance markers and reduced lipid peroxidation and cholesterol transporter gene expression in diabetic kidneys. Conclusion Targeting SOCS proteins by mimetic peptides to control JAK/STAT signaling pathway ameliorates albuminuria, morphological renal lesions, inflammation, oxidative stress and lipotoxicity, and could be a therapeutic approach to T2D kidney disease.
Supplementary Figures from The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>Supplementary Figure S1: Amino acid sequence of ANGPT2, ANGPT2443 and ANGTPT2DAP. Supplementary Figure S2: Competitive inhibition of ANGPT4-induced TIE2 phosphorylation by ANGPT2 isoforms. Supplementary Figure S3. TIE2 phosphorylation by ANGPT2 isoforms at the retracting cell edges. Supplementary Figure S4. Generation of Angpt2443 allele and the effects of Angpt2443 expression on the retina. Supplementary Figure S5. MMTV-PyMT mammary gland tumor model. Supplementary Figure S6. ANGPT2 at the Weibel-Palade bodies and the subendothelial space. Supplementary Figure S7. B16F10 melanoma lung colonization model. Supplementary Figure S8. E0771 breast cancer cell transplantation model.</p>
The link between central retinal thickness and retinal nerve fibre layer thickness in patients with retinitis pigmentosa

Field: Medicine (Health Sciences)

Abstract Purpose Linking central retinal thickness (CRT) with retinal nerve fibre layer thickness (RNFL) in retinitis pigmentosa (RP) patients. Methods 37 patients with typical RP and 19 age‐matched controls (p = 0.352), who underwent Spectral Domain Optical Coherent Tomography of the macula and optic disc, were included. The RP group was divided in two subgroups: with clinical appearance of macular oedema (ME‐RP; 30 eyes) and without it (no‐ME; 44 eyes). Macula OCT data were averaged in three zones [Z1 (0°–3°), Z2 (3°–8°) & Z3 (8°–15°)] and were evaluated in relation to the RNFL thickness. Results The subgroup ME‐RP differed significantly from the subgroup no‐ME‐RP by increased CRT (Z1) and increased averaged RNFL thickness, and when compared to controls (p ≤ 0.002). No‐ME‐RP group hat reduced CRT thickness (Z1‐3; p ≤ 0.018), compared to controls and ME‐RP, whereas the RNFL thickness in the no‐ME‐RP group was reduced only compared to ME‐RP group (p < 0.001). A significant positive interaction was found between the CRT (Z1 & Z2) and RNFL thickness within ME‐RP (p ≤ 0.010). Conclusion The presence of macular oedema correlated well with the increase in RNFL thickness in RP patients. Such association provide evidence for a common underlying mechanism of retinal degeneration. Simultaneous monitoring of CRT and RNFL thickness may help in the future to evaluate the progression of the disease and the efficacy of treatments for ME in RP.
The mobile mandibular ridge, a denture nightmare : review

Field: Dentistry (Health Sciences)

Successful denture wearers do not detect the gradual loss of retention and stability of dentures due to the slow rate of normal alveolar bone resorption and also to the ongoing habituation to unstable dentures that takes place. In addition to this are economical factors, especially in the aged that often lead to the wearing of dentures long beyond the desired clinical lifetime. The problem only becomes apparent when these patients present with peripheral pressure ulcers due to lack of denture contact on the basal tissues.
Techniques for Enumerating Veblen-Wedderburn Systems

Field: Mathematics (Physical Sciences)

article Free Access Share on Techniques for Enumerating Veblen-Wedderburn Systems Author: Erwin Kleinfeld Ohio State University, Columbus, Ohio Ohio State University, Columbus, OhioView Profile Authors Info & Claims Journal of the ACMVolume 7Issue 4Oct. 1960 pp 330–337https://doi.org/10.1145/321043.321047Published:01 October 1960Publication History 33citation347DownloadsMetricsTotal Citations33Total Downloads347Last 12 Months28Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
HUBUNGAN FAKTOR PREDISPOSING, ENABLING DAN REINFORCINGDENGAN PERILAKU SEKSUAL PRANIKAH PADA REMAJA SMA

Field: Social Sciences (Social Sciences)

Deviant sexual behavior among unmarried adolescents in terms of reproductive health tends to increase. Premarital sexual behavior in adolescents in high school. The phenomenon of sexual behavior among adolescents according to The Board of Coordinator for National Family Planning in the field as much as 52% had premarital sex.The objective of the research was to find out the correlation of predisposing factors, Enabling and Reinforcing the Pre-Marital Sexual Behavior in Adolescents XY high school in the city of Medan. The research used explanatory method and cross sectional study design. The data were gathered by conducting interviews and questionnaires and analyzed by using multiple logistic regression analysis at α = 0.05.The result of this study showed pre-marital sexual behavior 52.4% of high-risk category. Predisposing factors, 64.5% category is not good knowledge, the attitude of 57.3% in the negative category, socioeconomic 54.0% in the low category. Enabling factors; 54.8% of media access information on exposure category, 58.1% availability of the facilities available in the category. Reinforcing factors; 58.1% of parents have role category, 53.2% of peers have no role category. The result of statistic test showed that predisposing factors (knowledge, attitudes, social and economic) and enabling factors (media access to information and the availability of facilities) as well as reinforcing factors (the role of parents and the role of peers) were correlated (p < 0.05) with the pre sexual behavior marriage. The variable of knowledge had the most dominant correlation with the pre sexual behavior marriage.
Faktor-Faktor yang Mempengaruhi Prilaku Pemberian Asi Eksklusif di Kelurahan Tabona Kecamatan Kota Ternate Selatan

Field: Health Professions (Health Sciences)

Abstract : It is estimated that 80% of mothers who gave birth were able to produce milk in quantities sufficient for the purposes of the baby in full without any additional food and according to the World Health Organization recommends breastfeeding until the age of 4-6 months baby. Annually, more than 25,000 babies Indonesia and 1.3 million babies around the world can be saved by exclusive breastfeeding in 1999, while according to the 2000 report, the WHO approximately 1.5 million children die because they are not feeding properly, less than 15% infants worldwide are given for four months of exclusive breastfeeding and complementary feeding is often inappropriate and unsafe. This research is explanatory research because it explains the relationship between independent variables and dependent variable through hypothesis testing. The method used in this study is a survey method with cross sectional study design. The population in this study are all mothers who breastfeed in Puskesmas Kalumata 2012. Knowledge of the highest in the category of knowledge of both 81 (95.3%) and the behavior of the Exclusive breastfeeding is highest among respondents with a good knowledge of the 55 categories (67.9%). Respondents' attitudes toward breastfeeding Exclusive showed much respondeng that supports 54 (63.5%) and 31 (36.5%) that does not support exclusive breastfeeding her baby. Family Support tehadap respondents in the most exclusive breastfeeding: supporting respondents in exclusive breastfeeding her baby 64 (75.3%) and 21 (24.7%) who did not support the.