jimnoneill/paper-to-field-training huggingface dataset:
MON-277 Patient Health Questionnaire 9 (PHQ-9) and Barrat Impulsivity Scale (BIS-11); Tools to Identify Side Effects of Dopamine Agonist Treatment in Patients with Pituitary Adenomas

Field: Medicine (Health Sciences)

Abstract Background There is augmented concern for dopamine agonists (DA) related risk to mood and impulse control disorders (ICD) in patients (pts) with pituitary adenomas (PA). In this study, we analyzed prevalence using two validated self-assessment screening surveys; PHQ-9 and BIS-11. Methods A retrospective review of pts from an IRB approved PA registry. Patients; DA treated group (DA-T) and DA nontreated controls (DA-C). Patietns with previous psychiatric diagnoses, and taking anti-depressive or anti-psychotis, were excluded. BIS-11 score ≥ 75%ile (&gt;61 points) was considered an increased ICD risk. DAs maximum standard dose low (MSDL) and high (MSDH), were calculated (2.0 and 3.5 mg/week for cabergoline (Cab) and 7.5 and 15 mg/day for bromocriptine; Bromo). Stats SPSS v.25. Results 103 pts (61 female, mean age 42.38±5.38 years) were included. 76 were DA-T (70 Cab, 6 Bromo) and 27 DA-C. Median MSDL was 0.5mg (IQR: 0.25-0.75), MSDH was 0.28mg (IQR: 0.14-0.42). Median prolactin was 12.7ng/ml (IQR: 4.35-51.6). Overall median PHQ-9 score was 4 (IQR=2-9) and median BIS-11 score was 52 (IQR: 47-61). Per PHQ-9, 11/103 pts had major depressive disorder (MDD); 10 (13.2%) DA-T, 1 (3.7%) DA-C, p=0.28. 12/103 pts had other depressive disorder (ODD); 7 (9.2%) DA-T, 5 (18.5%) DA-C, p=0.19. 8 pts had thoughts of self-injury; 6 (7.9%) DA-T, 2 (7.4%) DA-C, p=NS. Severe depression was found in 3, (3.9%) DA-T pts only, moderately severe in 7 (9.2%) DA-T and 2 (7.4%) DA-C, moderate in 8 (10.5%) DA-T and 1 (3.7%) DA-C, and mild in 18 (23.7%) DA-T, 12 (44.4%) DA-C, p=NS. For BIS-11 (97 pts) median score was 52.0 (23-104) for DA-T, 52.5 (38-77) for DA-C. 23 pts had a score ≥ 75%ile, 18 (26.1%) DA-T and 5 (20%) DA-C. Younger pts (36±14.8 vs 43.5±15.09 years; p=0.043) and lower DA cumulative doses had significantly higher ICD scores (median 18.27, IQR 11.5-313.98 vs 120.4, IQR 48.04-296.5; p=0.022). Differences in prolactin levels and sex were not significant. Per PHQ-9; 26.1% of pts with vs 5.3% without increased ICD risk had MDD (p= 0.013). Depresion severity and the total PHQ-9 score were higher in pts with increased ICD risk (p≤0.001). Pts with an increased ICD had higher odds of having thoughts of death or self-harm (OR=6.29 CI95% 1.37-28.86, p=0.01). Discussion The data shows a trend of higher impulsivity among DA treated pts. Pts with increased ICD risk had higher odds of MDD, self-harm ideation and thoughts about being dead. In contrast with previous studies, prolactin and male sex were non-significant for increased ICD, while a lower DA cumulative dose was significant. We suggest ICD is more likely to appear in DA naïve or pts recently taking DA. Conclusion Routine self-assessment questionnaires PHQ-9 and BIS-11 during office visits may be useful to identify patients at risk of depression and ICD in pts with DA treated PA.
Considerations in the revision of previous surgical procedures

Field: Dentistry (Health Sciences)

The microbial etiology of periradicular periodontitis requires that efforts must be made to eliminate infection from the root canal system and the periradicular tissues. Periradicular surgery is an option of endodontic re‐treatment when non‐surgical root canal treatment and re‐treatment fails. Unfortunately, surgery is not always successful for a number of reasons including, extraradicular infection, associated marginal periodontal disease, inability to seal the root canal system from the periradicular tissues, anatomical anomalies and poor surgical technique. This paper reviews the use of re‐surgery in the treatment of failed surgical cases, discussing some of the problems that may be encountered and how they may be managed.
Intravenous Idursulfase for the Treatment of Mucopolysaccharidosis Type II: A Systematic Literature Review

Field: Medicine (Health Sciences)

Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is a rare, X-linked disorder caused by deficient activity of the enzyme iduronate-2-sulfatase. Signs and symptoms typically emerge at 1.5–4 years of age and may include cognitive impairment, depending on whether patients have the neuronopathic or non-neuronopathic form of the disease. Treatment is available in the form of enzyme replacement therapy (ERT) with recombinant iduronate-2-sulfatase (idursulfase). A systematic literature review was conducted to assess the evidence regarding efficacy, effectiveness, and safety of ERT with intravenous idursulfase for MPS II. Electronic databases were searched in January 2023, and 33 eligible articles were found. These were analyzed to evaluate the effects of intravenous idursulfase and the overall benefits and disadvantages in patient subgroups. Studies showed that intravenous idursulfase treatment resulted in improved short- and long-term clinical and patient-centered outcomes, accompanied by a favorable safety profile. Patients with non-neuronopathic MPS II had more pronounced improvements in clinical outcomes than those with neuronopathic MPS II. In addition, the review identified that improvements in clinical outcomes are particularly apparent if intravenous idursulfase is started early in life, strengthening previous recommendations for early ERT initiation to maximally benefit patients. This review provides a comprehensive summary of our current knowledge on the efficacy of ERT in different populations of patients with MPS II and will help to inform the overall management of the disease in an evolving treatment landscape.
Public engagement, historians and higher education: A retrospective UK case study

Field: Arts and Humanities (Social Sciences)

Focussing on the practice of public engagement and the teaching of history in higher education, this article will argue that public engagement is a welcome platform for sustaining humanities education through the economic stagnation and educational changes that have impacted Europe in the early 21st century. However, effective public engagement is becoming an increasingly important practice that universities are implementing all over the globe. Based on a case study of a course module run at a UK university for final-year undergraduates, this article proposes a practical framework for humanities departments to embed public engagement into departmental teaching programmes. It will demonstrate from the real-life experiences of staff and students engaged on a pilot programme how humanities subjects can also be practical skills-based learning experiences. The first section will review the current field of public engagement practice and methodology and explore why the subject has received much more attention over recent years, particularly within a UK context. The second section examines the case study itself, which was conducted during the 2009–10 academic year. The concluding section provides reflection and considers the possibilities for adopting a public engagement initiative within humanities departments in the future.
Urine interleukin-18 as early indicator to predict contrast-induced nephropathyin patients undergoing PCI or CAG

Field: Medicine (Health Sciences)

Objective To explore the change of urinary Interleukin-18(IL-18) levels after coronary angiography(CAG)and percutaneous coronary intervention(PCI),and evaluate its predictive value in early diagnosis of Contrast-induced nephropathy(CIN). Methods The general clinical data of 180 patients were collected in patients who underwent coronary interventional procedure from the department of Cardiology,Affiliated Hospital of Xuzhou Medical College from March,2012 to September,2012. Before and 2 h,6 h,12 h,24 h,48 h urinary IL-18 samples were measured by using enzyme linked immune sorbent assay(ELISA) kits. 3d preoperative and postoperative within 24 h,48 h conducted venous blood3 ml were used to detect Scr. Results 1CIN was diagnosed in 16 of 180 patients,the incidence rate was 8. 9%. In CIN group,urinary IL-18 concentration increased after 2h of the procedure,but the difference was not significant preoperative differences(P 0. 05);after 6h,12 h,24h of the procedure,urine IL-18 levels rose significantly compared with the preoperative(P 0. 05);while the Scr level of 48 h after operation was a significant difference( P 0. 05). 2The area under the ROC curve of urinary IL-18 12 h after the operation was 0. 811,confidence interval of AUC 95% was(0. 735,0. 888). If the cutoff point of the diagnosis of CIN was 815. 61 pg /ml,the sensitivity was 87. 5% and the specificity was62. 2%. 3Analysis showed that preoperative,postoperative urinary IL-18 and serum creatinine was positively related to the single variable(P 0. 05). Conclusion Urinary IL-18 has good predictive value for the early diagnosis of CIN in patients with coronary interventional procedure.
Research on Popular Children’s Literature in the 1950s - Focusing on “The Double Rainbow Hill” and “Yalgaejeon”

Field: Arts and Humanities (Social Sciences)

본고는 기존 아동문학사 저술에서 배제되거나 평가절하된 ‘통속 아동문학’을 재조명함으로써 아동문학의 정전화(正典化) 논의를 활성화하고자 했다. 문학 작품을 평가하는 데에서 ‘통속적’이라는 말은 흔히 부정적 의미로 쓰인다. 이는 아동문학 작품을 평가하는 데에서도 마찬가지인데, 아동문학은 무엇보다도 독자를 의식하고 성립한 장르인 만큼 통속성을 조금 다른 각도로 바라볼 필요가 있다. 김내성의 『쌍무지개 뜨는 언덕』과 조흔파의 『얄개전』은 각각 ‘순정소설’과 ‘명랑소설’이라는 장르적 성격을 활용해서 대중적으로 성공한 대표적인 사례에 해당한다. 본고는 그 성공 요인 가운데 전후(戰後)의 시대상황과 독자의 요구에 부응하는 면을 주목했다. 『쌍무지개 뜨는 언덕』은 무너진 가족 공동체의 복원 욕망을 충족시켰고, 『얄개전』은 일탈과 유희의 자유를 숨 쉬게 해주었다. 전자는 ‘눈물’을 자아내는 데 최적화된 ‘구성의 묘미’로, 후자는 ‘웃음’을 자아내는데 최적화된 ‘캐릭터 창조’로 후대에까지 영향을 미쳤다. 장르의 경계가 점점 희미해지고 ‘장르문학’과의 접속이 활발해지는 추세를 감안하다면, 특정 부류를 단순히 ‘통속적 경향’이라는 말로 외면해 버릴 게 아니라 속속들이 장단점을 따지면서 가난한 문학적 자산을 확충하는 방향으로 나아갈 필요가 있다.
Viscosity bounds in liquids with different structure and bonding types

Field: Physics and Astronomy (Physical Sciences)

Recently, it was realized that liquid viscosity has a lower bound which is nearly constant for all liquids and is governed by fundamental physical constants. This was supported by experimental data in noble and molecular liquids. Here, we perform large-scale molecular dynamics simulations to ascertain this bound in two other important liquid types: the ionic molten salt system LiF and metallic Pb. We find that these ionic and metallic systems similarly have lower viscosity bounds corresponding to the minimum of kinematic viscosity of ∼10−7m2/s. We show that this agrees with experimental data in other systems with different structures and bonding types, including noble, molecular, metallic, and covalent liquids. This expands the universality of viscosity bounds into the main system types known. Published by the American Physical Society 2024
Length of the Y Chromosome and Chromosomal Variants in Inpatient Children with Psychiatric Disorders: Two Studies

Field: Neuroscience (Life Sciences)

In a study of 41 inpatient boys with psychiatric disorders, it was found that this group had significantly increased length of the long arm of the Y chromosome (Yq+) as compared to a normal control group. The length of the Y chromosome in the inpatient group correlated with psychiatric symptom severity, hyperactivity, parental psychopathology and paternal alcoholism. A further study of minor chromosomal variants in 56 inpatient boys and girls revealed no differences in individual or pooled variants in the patient group, as compared to the control group. However, those in the patient group with one or more variants showed more severe psychiatric and other psychosocial symptoms than those in the group without variants. Those who had both longer Y chromosomes and a minor chromosomal variant had more severe psychiatric symptom severity.
P0552 / #1481: PERFORMANCE OF PAEDIATRIC INDEX OF MORTALITY 3 (PIM3) AS MORTALITY PREDICTOR IN PEDIATRIC CRITICAL CARE UNITS IN COLOMBIA AT 2500 METERS OVER THE SEA.

Field: Medicine (Health Sciences)

Aims & Objectives: Aim: In pediatric critical care, is necessary to use tools for prediction of mortality and compare to own outcomes. Paediatric index of mortality 3 (PIM 3) is one of the scores used for this. It is necessary to assess its performance in predicting mortality, according to the population in study. Objective: To validate PIM 3 score in pediatric critical care units at 2500 meters over the sea level in Colombia, and assess how other variables such as lactate and partial oxygen saturation (SpO2)/FIO2 ratio work in this model. Methods: Prospective, observational, national multicenter study. There were included six pediatric critical care units located at 2500 meters over the sea in Colombia with all the patients admitted consecutively during eight months. All the necessary information to calculate PIM 3, lactate and SpO2/FIO2 ratio was included. Results: A total of 2069 patients were analyzed. The mortality was 4.5% and the standardized ratio of mortality for PIM 3 was 1,19 (CI 95% 1,00 – 1,37). The score showed an inadequate calibration (p=0,01) and a good discrimination (AUC 0,84 CI: 0,83-0,86). A new proposed model using SpO2/FIO2 had a good discrimination and calibration. Conclusions: Mortality in Colombian children living at 2500 meters over the sea is similar to other countries. PIM 3 has a good discrimination but an inadequate calibration, this finding has many causes.The SpO2/FIO2 works for a better predictive value but is necessary to validate it with other population.
The Relationship of Statistical and Psychological Risk Markers to Sexual Reconviction in Child Molesters

Field: Psychology (Social Sciences)

This study examines the integration of statistical and psychological risk factors using psychometric markers of psychopathology and psychosexual characteristics from the Static-99 in 119 sexual offenders. Psychological risk markers are combined to approximate four deviancy domains: sexual interests, distorted attitudes, socio-affective functioning, and self-management. The sexual interests domain predicts sexual reconviction independent of Static-99. The four deviancy domains are used to calculate the Psychological Deviance Index, which was also found to predict sexual reconviction independent of Static-99. Organizing the Static-99 risk items into three subscales (sexual deviance, general criminality, and immaturity) reveals a distinct pattern of correlations within the psychological markers and risk domains. The Static-99 sexual deviance and general criminality subscales make modest predictions. Results support the use of integrating statistical and psychological markers within a risk domains framework in predicting sexual reconviction.
MARINE STEAM POWER PLANT HEAT BALANCE PRACTICES

Field: Engineering (Physical Sciences)

The purpose of this bulletin is to set forth data and practices for marine steam power plant heat balance calculations and diagrams. This bulletin is specifically applicable to oil fired steam turbine marine power plants at maximum continuous power, but with suitable modifications it can be used for other service ratings, other types of fuels, prime movers and auxiliary equipment. This bulletin includes data, practices, diagrams, symbols, abbreviations and forms for checking calculations. Every effort has been made to keep this bulletin as reasonable and fair as possible and close to the general practice of the industry, without curtailing individual initiative. When in the development of a design, specific data for the particular application becomes available, these data should be used in preference to the data given herein. An example calculation is performed, including the completion of the heat balance and flow diagram and a standard check sheet. Also included are blank forms that are presented as transparencies and perforated for easy removal and duplication. Similar Bulletins are currently being prepared by Panel M-15 covering marine diesel and gas turbine power plants thus affording the ship designer or ship owner an impartial basis to evaluate various types of propulsion systems.
Engineering probiotic Escherichia coli Nissle 1917 to block transfer of multiple antibiotic resistance genes by exploiting a type I CRISPR-Cas system

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ABSTRACT Many multidrug-resistant (MDR) bacteria have evolved through the accumulation of antibiotic resistance genes (ARGs). Although the potential risk of probiotics as reservoirs of ARGs has been recognized, strategies for blocking the transfer of ARGs while using probiotics have rarely been explored. The probiotic Escherichia coli Nissle 1917 (EcN) has long been used for treating intestinal diseases. Here, we demonstrate frequent transfer of ARGs into EcN both in vitro and in vivo , raising concerns about its potential risk of accumulating antibiotic resistance. Given that no CRISPR-Cas system was found in natural EcN, we integrated the type I-E CRISPR-Cas3 system derived from E. coli BW25113 into EcN. The engineered EcN was able to efficiently cleave multiple ARGs [i.e., mcr-1 , bla NDM-1 , and tet (X)] encoding enzymes for degrading last-resort antibiotics. Through co-incubation of EcN expressing Cas3-Cascade and that expressing Cas9, we showed that the growth of the former strain outcompeted the latter strain, demonstrating a better clinical application prospect of EcN expressing the type I-E CRISPR-Cas3 system. In the intestine of a model animal (i.e., zebrafish), the engineered EcN exhibited immunity against the transfer of CRISPR-targeted ARGs. Our work equips EcN with immunity against the transfer of multiple ARGs by exploiting the exogenous type I-E CRISPR-Cas3 system, thereby reducing the risk of the spread of ARGs while using it as a probiotic chassis for generating living therapeutics. IMPORTANCE To reduce the development of antibiotic resistance, probiotics have been considered as a substitute for antibiotics. However, probiotics themselves are reservoirs of antibiotic resistance genes (ARGs). This study introduces a new strategy for limiting the spread of ARGs by engineering the typical probiotic strain Escherichia coli Nissle 1917 (EcN), which has been used for treating intestinal diseases and developed as living therapeutics. We also demonstrate that the type I CRISPR-Cas system imposes a lower growth burden than the type II CRISPR-Cas system, highlighting its promising clinical application potential. Our work not only provides a new strategy for restricting the transfer of ARGs while using probiotics but also enriches the genetic engineering toolbox of EcN, paving the way for the safe use and development of probiotics as living therapeutics.
Archival Sources for the Study of McCarthyism

Field: Arts and Humanities (Social Sciences)

Journal Article Archival Sources for the Study of McCarthyism Get access Ellen W. Schrecker Ellen W. Schrecker assistant professor of history Yeshiva University Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 75, Issue 1, June 1988, Pages 197–208, https://doi.org/10.2307/1889667 Published: 01 June 1988
Electrical resistivity tomography at the DOE Hanford site

Field: Environmental Science (Physical Sciences)

Recent work at the DOE Hanford site has established the potential of applying Electrical Resistivity Tomography (ERT) for early leak detection under hazardous waste storage facilities. Several studies have been concluded to test the capabilities and limitations of ERT for two different applications. First, field experiments have been conducted to determine the utility of ERT to detect and map leaks from underground storage tanks during waste removal processes. Second, the use of ERT for long term vadose zone monitoring has been tested under different field conditions of depth, installation design, acquisition mode/equipment and infiltration chemistry. This work involves transferring the technology from Lawrence Livermore National Laboratory (LLNL) to the Resource Conservation and Recovery Act (RCRA) program at the DOE Hanford Site. This paper covers field training studies relevant to the second application for long term vadose monitoring. Electrical resistivity tomography is a cross-borehole, imaging technique for mapping subsurface resistivity variations. Electrodes are placed at predetermined depths in an array of boreholes. Electrical current is introduced into one electrode pair located in one borehole while the resulting voltage change is detected between electrode pairs in other boreholes similar to a surface dipole-dipole array. These data are topographically inverted to image temporal resistivity contrasts associated with an infiltration event. Thus a dynamic plume is spatially mapped as a function of time. As a long-term vadose zone monitoring method, different field conditions and performance requirements exist than those for short term tank leak detection. To test ERT under these conditions, two vertical electrode arrays were constructed to a depth of 160 feet with a linear surface array between boreholes. The fielding was used to facilitate the technology transfer from LLNL to the Hanford RCRA program. Installation methods, commercial equipment and acquisition mode were evaluated to determine economic and technical feasibility to assist design of long-term monitoring networks. Preliminary results of the training test are presented. Until recently, vadose zone monitoring techniques could provide only local point or linear coverage for leak detection and thus, are used primarily under liquid collection systems at land disposal units. As developed by LLNL, ERT can provide areal coverage under waste treatment and storage facilities given the right conditions. Advantages of ERT to groundwater protection programs are explored along with suggestions for future uses where ERT can be employed today.
KNOWLEDGE AND THEIR SHELF LIFE IN THE BUSINESS CYCLE Abstract : In the attempt to draw a definition to the business topics of the current period, we report to a string of descriptive key words, which appeal to a growing amount of assets, other than the physical/tangible ones. Thus, the most used words/keywords are: knowledge, skills/abilities or talents and the successful leaders that can use/exploit them productively, to achieve competitive advantage, become the key individuals in the business organizations. This is partly due to the "promise" that "the world of intangibles" guarantee to the modern corporate success. Thus, knowledge has become valuable resources in the current competitive chaos. The issue of this paper focuses on how knowledge are used in business organizations, where they can be located within the organization domain and which is their shelf life/their term of validity comparing to the one of those tangible/physical.

Field: Business, Management and Accounting (Social Sciences)

business organizations, innovation, knowledge, shelf life, tacit knowledge
Creating a common discourse on practitioner inquiry as stance

Field: Social Sciences (Social Sciences)

Abstract Practitioner Inquiry (PI) is the systematic, intentional study of one's professional practice. It makes reflective teaching visible and actionable. In this article, we reflect on our experiences as practitioner researchers across elementary, secondary, and teacher education and engage in critical conversations with one another to present a common discourse around the complexities of PI. We elucidate the ways that PI positions literacy educators as self‐directed learners, agents of change, and storytellers to recenter literacy teaching and learning.