jimnoneill/paper-to-field-training huggingface dataset:
The Ets2 Transcription Factor Inhibits Apoptosis Induced by Colony-Stimulating Factor 1 Deprivation of Macrophages through a Bcl-xL-Dependent Mechanism

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Bcl-xL, a member of the Bcl-2 family, inhibits apoptosis, and its expression is regulated at the transcriptional level, yet nothing is known about the transcription factors specifically activating this promoter. The bcl-x promoter contains potential Ets binding sites, and we show that the transcription factor, Ets2, first identified by its sequence identity to v-ets of the E26 retrovirus, can transactivate the bcl-x promoter. Transient expression of Ets2 results in the upregulation of Bcl-xL but not of Bcl-xS, an alternatively spliced gene product which induces apoptosis. Ets2 is ubiquitously expressed at low levels in a variety of cell types and tissues but is specifically induced to abundant levels during macrophage differentiation. Since Bcl-xL is also upregulated during macrophage differentiation, we asked whether the bcl-x could be a direct downstream target gene of Ets2 in macrophages. BAC1.2F5 macrophages, which are dependent on macrophage colony-stimulating factor 1 (CSF-1) for their growth and survival, were used in these studies. We show that CSF-1 stimulation of BAC1.2F5 macrophages results in the upregulation of expression of ets2 and bcl-xL with similar kinetics of induction. In the absence of CSF-1, these macrophages undergo cell death by apoptosis, whereas constitutive expression of Ets2 rescues these cells from cell death, and bcl-xL is upregulated. These results strongly suggest a novel role of Ets2 in affecting apoptosis through its regulation of Bcl-xL transcription.
Residual levels of total sulphur dioxide in dried fruit samples from Belgrade market

Field: Environmental Science (Physical Sciences)

Sulphiting agents have been used in food production for centuries. Sulphites are added to food as antimicrobial, antibrowning agents or antioxidants. Their use became an issue of concern when certain sensitive individuals exhibited adverse reactions to sulphite residues in foods. Sulphites also exert a number of different anti-nutritive effects. Like other ingredients, sulfites must be declared in the ingredient statement. Among all sulphite-containing foods, the highest contributors to the dietary intake are dried fruits and wine. The aim of this work was to determine residual levels of total sulphur dioxide in dried fruit samples in order to examine the risk of exceeding the Acceptable Daily Intake (ADI) for sulphites by consuming this type of food. The other scope of the study was to investigate compliance with food labeling in order to insure consumer protection. The determination was performed on all samples by colorimetric para-rosaniline method, according to the official method of analysis of AOAC 963.20 (AOAC 2002).Twelve different samples of dried fruit were analyzed. Results showed that dried fruit is very rich source of sulphites. The range of residual sulphur-dioxide was very large, from nondetectable levels (in three samples) to 1847.3 mgSO2/kg. In ten of twelve samples SO2 levels were under national Maximum Permitted Level (MPL). SO2 content was above MPL in dried bananas sample and dried sweet coconut. Just eight of twelve fruit samples had label declarations of sulfite content but the determined levels of sulfites were significantly above the declared levels.
Ibu Heni 0822-1455-5757 Distributor Herbalife di Ngoro Jombang

Field: Health Professions (Health Sciences)

Hubungi Ibu Heni 0822-1455-5757 Alamat, Distributor Herbalife di Majalengka Jawa Barat\n\nAlamat Agen Distributor Herbalife di Majalengka Jawa Barat, Distributor Herbalife di Tanggul Jember, Distributor Herbalife di Tempurejo Jember, Distributor Herbalife di Umbulsari Jember, Distributor Herbalife di Wuluhan Jember, Distributor Herbalife di Bandar Kedung Mulyo Jombang, Distributor Herbalife di Bareng Jombang, Distributor Herbalife di Diwek Jombang\n\nKelas Diet Online Program Slim Marathon 10 Hari Herbalife.\n\nCOACH NIA TLP WA 0822-1455-5757\nKami adalah distributor Resmi Herbalife produsen makanan kesehatan\nKelas Diet Online\nAgen Herbalife\nHerbalife Terdekat\nNo Telepon Kelas Diet Online\n\n\n#DistributorHerbalifediMajalengkaJawaBarat, #DistributorHerbalifediTanggulJember, #DistributorHerbalifediTempurejoJember, #DistributorHerbalifediUmbulsariJember, #DistributorHerbalifediWuluhanJember, #DistributorHerbalifediBandarKedungMulyoJombang, #DistributorHerbalifediBarengJombang, #DistributorHerbalifediDiwekJombang\n\n
A Brain-Controlled Vehicle System Based on Steady State Visual Evoked Potentials

Field: Computer Science (Physical Sciences)

Abstract In this paper, we propose a human-vehicle cooperative driving system. The objectives of this research are twofold: (1) providing a feasible brain-controlled vehicle (BCV) mode; (2) providing a human-vehicle cooperative control mode. For the first aim, through a brain-computer interface (BCI), we can analyse the EEG signal and get the driving intentions of the driver. For the second aim, the human-vehicle cooperative control is manifested in the BCV combined with the obstacle detection assistance. Considering the potential dangers of driving a real motor vehicle in the outdoor, an obstacle detection module is essential in the human-vehicle cooperative driving system. Obstacle detection and emergency braking can ensure the safety of the driver and the vehicle during driving. EEG system based on steady-state visual evoked potential (SSVEP) is used in the BCI. Simulation and real vehicle driving experiment platform are designed to verify the feasibility of the proposed human-vehicle cooperative driving system. Five subjects participated in the simulation experiment and real the vehicle driving experiment. The outdoor experimental results show that the average accuracy of intention recognition is 90.68 ± 2.96% on the real vehicle platform. In this paper, we verified the feasibility of the SSVEP-based BCV mode and realised the human-vehicle cooperative driving system.
Multi-wave temperature radiometer by high-speed camera

Field: Physics and Astronomy (Physical Sciences)

Two-color radiometry by a high-speed camera is effective to obtain the temperature distribution map of high temperature phenomenon, which changes its figure rapidly. We have developed the two-color method by a color high-speed camera and put it into practical use. However, in the case of phenomenon that has chemical luminescence besides the thermal emission, it is difficult to get accurate data from the method that measures visible wavelength images. In case that chemiluminescence is in visible wavelengths but not in near-infrared region, we can obtain high-speed NIR images and high-speed temperature distribution map by two frame-synchronized high-speed cameras which are equipped with NIR band-pass filters. We would report on the result of an experiment using an optical bench and software which we have developed.
Influence of Field Position on Rugby League Players Requiring Shoulder Reconstruction

Field: Medicine (Health Sciences)

A consecutive series of patients sustaining their index anterior instability while playing Rugby League and requiring shoulder reconstruction was retrospectively reviewed and evaluated. The details of their on-field position and hand dominance at time of injury, the side of injury, and mechanism of injury were collated and statistically analyzed. A total of 173 Bankart repairs were performed on 132 patients, and 102 players had one injury while 30 had 2 or more injuries. Players are more likely to injure their non-dominant side (P=0.009) in the first-time injury. Whereas second and subsequent injuries were not associated with a particular side (P=0.81). Applying a Bonferroni correction to the chi-squared goodness-of-fit test of position at time of injury revealed players on the wing had a significantly lower frequency of injury (P<0.001), whereas the full back had a significantly higher frequency of injury (P<0.001). 30 players sustained 69 re-dislocations with the lock and fullback positions incurring significantly more re-injuries and the wing position fewer re-injuries than expected (P<0.006). Understanding which player positions on the rugby league field are more likely to sustain an anterior instability will assist medical and support staff to optimize the pre-season conditioning and post surgical rehabilitation of players.
Identification of QTL for drought responses in maize and their use in testing causal relationships between traits

Field: Agricultural and Biological Sciences (Life Sciences)

A difficulty in identifying traits that help crop plants maintain their yield under droughted conditions is distinguishing between those traits that contribute to yield stability under drought and traits that do not affect yield. With the development of molecular markers for many crops it is now possible to identify major quantitative trait loci (QTL) regulating specific drought responses. By comparing the coincidence of such QTL for specific traits it is possible to test much more precisely than before whether a particular constitutive or adaptive response to drought stress is likely to be of significance in improving drought resistance. We have used this approach to identify QTL for ABA content and other traits likely to be important in determining drought response in maize. Eighty-four RFLP markers were mapped in an F2 population of 81 plants from a cross between parents, Polj17 (drought resistant) and F-2 (drought sensitive), that differ markedly in many constitutive and adaptive responses to drought stress. In a soil glasshouse experiment, from which water was withheld for 3 weeks after anthesis, flowering time, stomatal conductance, tissue ABA contents, leaf water relations parameters and fluorescence characteristics, root pulling force, and nodal root number were measured. The minimum number and location of genes having major effects on the traits were determined and possible causal relationships amongst them tested. Comparing the coincidence of QTL for ABA content and stomatal conductance showed that xylem ABA content was more likely to have had a regulatory effect on the stomatal conductance of those plants than the whole leaf ABA content. However, both xylem and leaf ABA contents were significantly associated with root characteristics, suggesting that the rooting behaviour (either constitutive or adaptive) was important in regulating stress responses, particularly in determining xylem ABA contents. We also found that Fm (a measure of the activity of photosynthetic reaction centres) was positively associated with chlorophyll concentration per unit area. Different methods for comparing QTL are presented and discussed.
Academics draft protocol for handling research misconduct

Field: Social Sciences (Social Sciences)

The UK body responsible for advising academic institutions and NHS trusts on how to deal with research misconduct has launched a protocol to try to standardise the procedure for investigating allegations and ensure that cases are handled fairly.

The protocol is a step by step guide to investigating and acting on allegations of research misconduct brought by other colleagues or external bodies, from the types of documentary evidence required, to who should be involved and over what time frame.

It is targeted at all employers of people engaged in research who rely on funds from government …
A clinical improvement of a idiopathic cervical dystonia in a patient treated with transdermal Rotigotine: a case-report.

Field: Medicine (Health Sciences)

Dystonia is the third most common movement disorder. Cervical dystonia is the most common form of dystonia, a subtype of Primary Focal Dystonia due to the phasic and/or tonic involuntary contractions of different combinations of neck muscles, generally treated with good clinical results with botulin toxin type A or B injection. The etiology of cervical dystonia is still unknown. It was recently proposed that the cervical dystonia is due to malfunctioning of the head neural integrator, that result of impairment in cerebellar, basal ganglia, or proprioceptive feedback. The hypothesis of the existence of an electrical circuit that connects the basal ganglia with the cerebellum and the proprioception feedback, participating in the neural integrator of the head, explains that the damage at any point of the network can lead to motor deficits. Although dystonia is often associated with abnormal dopamine neurotransmission, dopaminergic drugs are not currently used to treat dystonia because there is a general view that they are ineffective. The results from the clinical trials and tests in mice suggest that the coactivation of D1 and D2 dopamine receptors may be an effective therapeutic strategy in some patients. These results support the assumption that dopamine receptors could be considered as targets for treating dystonia. Furthermore, a dopamine agonist-response dystonia in patients with an autosomal recessive L-amino acid decarboxylase deficiency, has been described in the scientific literature. We report a case of focal cervical dystonia successful treated with a dopamine agonist (D3>D2>D1) Rotigotine, a transdermal drug that induces a continuous dopaminergic stimulation.
Building the Creative Economy: Managing Creative Capital in Museum's Development Departments

Field: Arts and Humanities (Social Sciences)

viii, 34 p. A MASTER’S CAPSTONE \nPRESENTED TO THE ARTS AND ADMINISTRATION PROGRAM \nOF THE UNIVERSITY OF OREGON \nIN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE \nDEGREE OF MASTER OF SCIENCE IN ARTS AND ADMINISTRATION.
Presentation : Spatial Analysis and GEOmatics

Field: Social Sciences (Social Sciences)

SAGEO is the annual International Conference on Spatial Analysis and GEOmatics. It aims to: present recent and high quality research in the field of Geomatics and Spatial Analysis, bring together researchers from various disciplines, provide an exchange platform on research and development in Geomatics, on a national and international level, for public or private bodies. SAGEO is a good opportunity for two complementary research networks to meet and to discuss their points of view on spatial...
Catalysis of Amide Proton Exchange by the Molecular Chaperones GroEL and SecB

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Hydrogen-deuterium exchange of 39 amide protons of Bacillus amyloliquefaciens ribonuclease (barnase) was analyzed by two-dimensional nuclear magnetic resonance in the presence of micromolar concentrations of the molecular chaperones GroEL and SecB. Both chaperones bound to native barnase under physiological conditions and catalyzed exchange of deeply buried amide protons with solvent. Such exchange required complete unfolding of barnase, which occurred in the complex with the chaperones. Subsequent collapse of unfolded barnase to the exchange-protected folding intermediate was markedly slowed in the presence of GroEL or SecB. Thus, both chaperones have the potential to correct misfolding in proteins by annealing.
The situated nature of historical understanding

Field: Social Sciences (Social Sciences)

This paper reports on a year-long qualitative study of two elementary classrooms in a suburban community near Cincinnati (Ohio). The classes were very homogeneous racially with no students of Hispanic, Afr.can-American, Asian, or Pacific Island descent in either class. Incerviews, classroom observations and participation, and analysis of student&apos;s written assignments were conducted to examine the historical understanding students brought to school, the social context in which their thinking had developed, and the way their ideas affected their encounter with the content of the school curriculum. Students developed their understanding of the past primarily through interactions with relatives, and they used that understanding to construct a narrative of historical development which explained their own lives in the present. This study suggests that research and instruction should begin not with the content of the school curriculum or the nature of the historical disciplinc. but with th-a cultural context in which students &apos; historical understanding develops. Contains 84 referencds. (EH).A.***-A-***-::::*****.*-:-**::*-::*******f:****-::***::::*;:*********.A.******.;:************ Reproductions supplied by EDRS are the best that can be made from the original document.
Idiopathic male infertility – what are we missing?

Field: Medicine (Health Sciences)

Couple's infertility is a rising issue worldwide affecting approximately 15% of couples. In 50% of the couples, a male factor infertility can be identified. Moreover, 30% of the men exhibit reduced sperm quality without any identifiable reason, thereby delineating the condition of idiopathic male infertility (IMI). Despite numerous improvements in the diagnosis and treatment of male infertility over the last decades, idiopathic forms are still the most challenging clinical dilemmas. The aim of this article is to describe the comprehensive diagnostic work-up that each idiopathic infertile man should follow. Moreover, potential new pathophysiological mechanisms and suggested treatment options are discussed. A detailed medical history and an extensive physical examination are mandatory to investigate potential treatable causes of MFI. Similarly, standard semen analysis has been proven to be limited in capturing the fecundability of the spermatozoa itself, therefore more advanced examinations, such as sperm DNA fragmentation (SDF) and oxidative stress measurement, are becoming important in clinical practice for IMI. In terms of diagnostic tools, imaging and genetic investigations are useful to classify idiopathic infertile men, however, epigenetic changes have demonstrated to have a role in sperm production and a prognostic value in fertility outcomes. Antioxidant treatment for IMI has been found to be a valid option to counteract ROS action, while gonadotropins are used to improve sperm quality and SDF. Artificial intelligence is promising to better manage idiopathic infertile men in terms of diagnosis and treatment options.
The Herfindahl-Hirschman Index as an official statistic of business concentration : challenges and solutions

Field: Economics, Econometrics and Finance (Social Sciences)

ENGLISH ABSTRACT: This dissertation examines the measurement of business concentration by the Herfindahl-
Hirschman Index (HHI). In the course of the examination, a modification to this method of
measurement of business concentration is proposed, in terms of which the accuracy of the
conventional depiction of the HHI can be enhanced by a formulation involving the Gini index.
Computational advantages in the use of this new method are identified, which reveal the Ginibased
HHI to be an effective substitute for its regular counterpart. It is found that theoretically and
in practice, the proposed new method has strengths that favour its usage. The practical
advantages of employing this method are considered with a view to encouraging the measurement
of business concentration using the Gini-based index of the HHI.%%%%AFRIKAANSE OPSOMMING: Hierdie verhandeling ondersoek die meting van sakekonsentrasie deur middel van die Herfindahl-
Hirschman-indeks (HHI). ‘n Wysiging aan hierdie metode word voorgestel, deur middel waarvan
die akkuraatheid van die konvensionele voorstelling van die HHI verhoog word, deur ‘n
formulering wat die Gini-indeks betrek. Die berekeningsvoordele van hierdie nuwe metode word
geidentifiseer en dit word aangetoon dat die Gini-gebaseerde HHI ’n doeltreffende plaasvervanger
vir sy meer bekende teenvoeter is. Daar word bevind dat die voorgestelde nuwe metode
teoretiese en praktiese sterkpunte het wat die gebruik daarvan ondersteun. Die praktiese voordele
van die voorgestelde metode word oorweeg met die oog op die aanmoediging van die gebruik van
die Gini-gebaseerde HHI-indeks as maatstaf van sakekonsentrasie.
DataSheet_1_Association of metformin use with fracture risk in type 2 diabetes: A systematic review and meta-analysis of observational studies.docx

Field: Medicine (Health Sciences)

Aims<p>Increasing evidence suggests that metformin can affect bone metabolism beyond its hypoglycemic effects in diabetic patients. However, the effects of metformin on fracture risk in type 2 diabetes mellitus (T2DM) patients remain unclear. A systematic review and meta-analysis were performed in this study to evaluate the association between metformin application and fracture risk in T2DM patients based on previous studies published until June 2021.</p>Methods<p>A systematic search was performed to collect publications on metformin application in T2DM patients based on PubMed, Embase, Cochran, and Web of Science databases. Meta-analysis was performed by using a random-effects model to estimate the summary relative risks (RRs) with 95% confidence intervals (CIs). Subgroup analyses based on cohort/case-control and ethnicity and sensitivity analyses were also performed.</p>Results<p>Eleven studies were included in the meta-analysis. Results demonstrated metformin use was not significantly associated with a decreased risk of fracture (RR, 0.91; 95% CI, 0.81–1.02; I<sup>2 =</sup> 96.8%). Moreover, metformin use also demonstrated similar results in subgroup analyses of seven cohort studies and four case-control studies, respectively (RR, 0.90; 95% CI, 0.76–1.07; I<sup>2 =</sup> 98.0%; RR, 0.96; 96% CI, 0.89–1.03; I<sup>2 =</sup> 53.7%). Sensitivity analysis revealed that there was no publication bias.</p>Conclusion<p>There was no significant correlation between fracture risk and metformin application in T2DM patients. Due to a limited number of existing studies, further research is needed to make a definite conclusion for clinical consensus.</p>
Detection of a warm molecular wind in DG Tauri

Field: Physics and Astronomy (Physical Sciences)

We detect near-infrared H2 emission in DG Tau using the Infrared Camera and Spectrograph (IRCS) on the 8.2-m SUBARU telescope. The spectra obtained along the jet axis show that the centroidal position of the 1-0 S(1) emission is offset by 0.2" from the star towards the jet, while those obtained perpendicular to the jet axis show a marginal extension, indicating that the emission line region has a typical width of ~0.6". Their line profiles show a peak velocity of ~15 km s^-1 blueshifted from the systemic velocity. These results indicate that the emission originates from a warm molecular wind with a flow length and width of ~40 and ~80 AU, respectively. The line flux ratios I_{1-0 S(0)}/I_{1-0 S(1)} and an upper limit for I_{2-1 S(1)}/I_{1-0 S(1)}) suggest that the flow is thermalized at a temperature of ~2000 K, and is likely heated by shocks or ambipolar diffusion. The observed velocity and spatial extension suggest that the H2 and forbidden line emission originate from different components of the same flow, i.e., a fast and partially ionised component near the axis and a slow molecular component surrounding it. Such a flow geometry agrees with model predictions of magneto-centrifugal driven winds.
Surgical management of intrathoracic aortic aneurysm.

Field: Medicine (Health Sciences)

The pathology, clinical features, indications for surgery and the results of intrathoracic aneurysm are analysed in thirty-nine consecutive patients who underwent surgery at Singapore General Hospital from January 1986 through December 1990. There were twenty cases of non-dissecting aneurysm and nineteen cases of dissecting aneurysm or aortic dissection. The 30 day survival for the twenty patients with non-dissecting aneurysm was sixteen patients (80%). The best results were obtained in patients with aortic root aneurysms. The overall 30-day survival for the nineteen patients with aortic dissection was twelve patients (64%). The mortality was especially high in patients with acute aortic dissection (46%). Recent advances in the management of these aneurysms make early recognition and diagnosis mandatory to achieve the best results.