jimnoneill/paper-to-field-training huggingface dataset:
MinuteSupernumerary RingChromosome22Associated with CatEyeSyndrome: Further Delineation oftheCritical Region

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Summary Cateyesyndrome (CES) istypically associated witha supernumerary bisatellited marker chromosome (inv dup22pter-22qll.2) resulting infour copies ofthis region. Wedescribe anindividual showing theinheritance ofaminute supernumerary double ring chromosome 22,which resulted inexpression ofall cardinal features ofCES.Thesize ofthering wasdetermined byDNA dosage analysis andFISHanalysis forfive loci mapping to22q11.2. Theprobes totheloci D22S9, D22S43, and ATP6Ewerepresent infourcopies, whereas D22S57 andD22S181 werepresent intwocopies. Thisfinding further delineates thedistal boundary ofthecritical regionofCES,withATP6Ebeing themostdistal duplicated locus identified. Thephenotypically normal father andgrandfather ofthepatient each hadasmall supernumerary ring chromosome anddemonstrated three copies fortheloci D22S9, D22S43, andATP6E.Although three copies ofthis region havebeenreported inother cases withCESfeatures, itispossible that thepresence offour copies leads togreater susceptibility.
Attempts to Regulate the Legal Status of Private Military and Security Companies in the Russian Federation and Ukraine

Field: Social Sciences (Social Sciences)

Russian Federation and Ukraine are two ex-Soviet states that do not admit in the national legislation related to ensuring the security of the state any form of involvement of the private factor that could threaten or limit the exclusive and sovereign right of the state to use armed force. However, the experience of the Russian Federation turns out to be quite extensive in terms of using the specific services of private military and security companies officially registered outside the country. Also, after the events of 2014, in Ukraine there is an intensification of the legal regulation initiatives of the legal status of private military and security companies. In this article, it is proposed to analyze the essence of the initiatives for legal regulation of the status of private military and security companies in the Russian Federation and Ukraine, in order to highlight the necessity and importance of this process, as well as the specific approaches in the states under analysis.
The Skill of Self-Management for School Principals in Digital Education

Field: Social Sciences (Social Sciences)

School self-management has come to be seen as a participatory and collaborative process between all school teachers and the surrounding community and its institutions. This quantitative study examines reality using the self-management of school principals. The sample of the study involved 215 principals of schools in the green line region of Palestine. A questionnaire was emailed and posted on social media (Facebook and WhatsApp) to collect data. The Statistical Package for Social Sciences was used to analyze the data. The findings of the study were: (i) self-management faces great challenges in its application; (ii) principals do not involve teachers and society in decision-making. (iii) The inability of school principals to set the general objectives of the curriculum due to a lack of experience; (iv) Some principals were unable to create teachers who carried out their duties through self-management.
Munawar Iqbal: Zakah, Moderation and Aggregate Consumption in an Islamic Economy, Comment منور إقبال: الزكاة والاعتدال والاستهلاك الكلي في الاقتصاد الإسلامي - تعليق: محمد فهيم خان

Field: Economics, Econometrics and Finance (Social Sciences)

Consumption function in Islamic framework has attracted in this Journal more attention than any other micro or macro-aspect of Islamic economic system. Yet, all these half a dozen presentations have simply focused on a trivial issue i.e. implication of Islamization of an economy on the propensity to consume in a simple Keynesian macro-economic framework. Whether imposition of Zakah will increase or decrease the propensity to consume is not a substantial issue. All presentations made so far, whether proving an increased propensity or decreased propensity to consume, indicate only a marginal increase or decrease. For example, see Ausaf (1985) and Metwally (1981). --
Multiple Assessments of a First-Year Seminar Pilot

Field: Social Sciences (Social Sciences)

Research Article| January 01 2009 Multiple Assessments of a First-Year Seminar Pilot Andrew Barton; Andrew Barton Search for other works by this author on: This Site Google Christiane Donahue Christiane Donahue Search for other works by this author on: This Site Google The Journal of General Education (2009) 58 (4): 259–278. https://doi.org/10.2307/25702447 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Andrew Barton, Christiane Donahue; Multiple Assessments of a First-Year Seminar Pilot. The Journal of General Education 1 January 2009; 58 (4): 259–278. doi: https://doi.org/10.2307/25702447 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectivePenn State University PressThe Journal of General Education Search Advanced Search The text of this article is only available as a PDF. Copyright © 2010 The Pennsylvania State University2010The Pennsylvania State University Article PDF first page preview Close Modal You do not currently have access to this content.
CTIM-25. PHASE2B/3 STUDY OF NEOANTIGEN-SPECIFIC T CELL IMMUNOTHERAPY IN NEWLY DIAGNOSED O6 – METHYLGUANINE METHYLTRANSFERASE UNMETHYLATED (MGMT -) GLIOBLASTOMA

Field: Medicine (Health Sciences)

Abstract MGMT- glioblastoma (GBM) is the most common malignant primary brain tumor, yet outcomes have not improved in decades despite intensive investigations. TVI-AST-008 is a randomized clinical trial of a novel neoantigen-specific T cell immunotherapy regimen proven invariably curative in rodent models and clinically effective in trials of patients with relapsed/resistant GBM. TVAX neoantigen-specific T cell immunotherapy exploits the fact that cancer cells express neoantigens, and adoptive transfer can bypass the immunosuppressive milieu near the resection cavity. In this manner, TVAX effector T cells initiate apoptosis in any residual GBM. After pathologic confirmation, autologous GBM tumor tissue sent to the TVAX GMP manufacturing facility is irradiated and utilized for proprietary vaccine production. Patients are vaccinated with a series of two intradermal injections and the resulting cancer neoantigen-specific T cells are harvested by leukapheresis. These T cells are activated and proliferated ex vivo by TVAX manufacturing to generate effector T cells. These are re-infused following standard radio-chemotherapy, followed by low-dose interleukin-2 to further stimulate T cell proliferation. In the study, MGMT- GBM patients are randomly assigned to treatment or control arms. Patients in the treatment arm undergo vaccination, then standard concurrent IMRT-chemotherapy, followed by re-infusion of TVAX autologous effector T cells. Patients in the control arm undergo standard IMRT-chemotherapy followed by adjuvant chemotherapy with temozolomide. TVI-AST-008 is an ongoing, randomization-controlled study with Fast Track designation from the FDA. The primary end point is overall survival. Additional end points include progression free survival, safety and immune response. Patients are followed with physical exams and surveillance MRI for evidence of disease progression. The trial is targeted for 15 centers in the US.
The inter-rater reliability of the Smith hand function test: A South African perspective

Field: Health Professions (Health Sciences)

Introduction The Smith hand function test is a performance-based hand function assessment with limited evidence on its psychometric properties. This study was conducted to investigate the inter-rater reliability of the Smith hand function test and for consideration in a developing country context. Methods Twenty-two participants living in Cape Town, South Africa were selected by convenience sampling. The sample performed test–retest of the Smith hand function test items four times by four different raters. The inter-rater reliability was calculated using intraclass correlation coefficients, with 95% confidence interval, testing absolute agreement and consistency. Results The intraclass correlation coefficients were above 0.75 for all subtests apart from the button board test item. This item had intraclass correlation coefficients of 0.579 (agreement) and 0.577 (consistency) with a standard deviation of 3.64 s and a 0.39 s standard error of measurement. Conclusions The inter-rater reliability of the Smith hand function test following a test–retest design by multiple raters was good. This suggests that further psychometric studies on the Smith hand function test could be valuable for clinical hand practice.
Shared Batteries Business Models for Energy Communities

Field: Energy (Physical Sciences)

&lt;p&gt;The deployment of energy communities (EC) will foster new business models contributing to the decentralization and democratization of energy access and a reduction in the&nbsp;energy bill of final consumers. This decentralization is only possible if investments are made in production and storage&nbsp;technologies, that must be installed near the locals of consumption, according to&nbsp; common rules of the regulatory frameworks of EC. In this paper we propose a methodology for the optimal sizing of&nbsp; production and shared storage assets, and we assess the cost reduction of considering shared storage assets.&nbsp;We then formulate seven business models (BM) that dictate how to share this benefit among the EC members, and we propose two indicators to assess them. Results show the difficulty in choosing a BM as well as the limitations of the BM and of the indicators.&lt;/p&gt;
Use of Neural Nets For Dynamic Modeling and Control of Chemical Process Systems

Field: Chemical Engineering (Physical Sciences)

Neural nets are inherently parallel and they hold great promise because of their ability to "learn" nonlinear relationships. This paper discusses the use of backpropagation neural nets for dynamic modeling and control of chemical process systems. The backpropagation algorithm and its rationale are reviewed. The algorithm is applied succesfully to model the dynamic response of pH in a CSTR. The use of backpropagation models for control is briefly discussed.
COMMENTARY The Problem with Breastfeeding Discourse

Field: Health Professions (Health Sciences)

This paper reflects on how informational biases have subtly entered into the breastfeeding health discourse and recommends how focus might be redirected. Specifically, contemporary infant feeding health discourse reflects a biased representation of the scientific literature, and fails to provide an appropriate contextualization of risk and benefit. It is important to correct these biases in order to uphold the foundational ethics of expert-guided childcare, and to rightly reposition the discourse as a tool for influence via education, not informational manipulation. Correcting these biases would also ease the discursive pressure and associated emotional burdens mothers currently experience in relation to infant feeding, and would reinforce a needed commitment to the development of appropriate supports to help mothers viably exercise their right to breastfeed. MeSH terms: Breastfeeding; ethics; health promotion; health education; public health practice
Tailoring Mesoporous Silicon Surface to Form a Versatile Template for Nanoparticle Deposition

Field: Materials Science (Physical Sciences)

Porous silicon (PS) can be used as a loading template in sensing or as a matrix to develop nanoparticle arrays. We present a comprehensive study of PS morphology and optical properties before and after the pore opening process, including the determination of thickness, pore size, and pore density of PS layers, its surface wettability, and reflectivity. The PS samples were fabricated by electrochemical anodization of monocrystalline silicon wafer in 5–20 wt.% hydrofluoric acid (HF) solution at a current density in the range of 20–200 mA/cm2. Anodization was followed by the pore opening process, i.e., the removal of a parasitic superficial layer with a “bottleneck” structure by reactive ion etching (RIE). The results illustrate that “bottleneck”-free PS allows to achieve a high pore density using a low HF concentration and a reduced current density. We established that this structure demonstrates higher hydrophobicity in comparison to the samples before RIE. The applicability of the developed “bottleneck”-free PS was tested via filling the pores with silver nanoparticles, indicating its potential use as a template for the fabrication of nanoparticle arrays.
Volume tracking using higher dimensional isosurfacing

Field: Computer Science (Physical Sciences)

Tracking and visualizing local features from a time-varying volumetric data allows the user to focus on selected regions of interest, both in space and time, which can lead to a better understanding of the underlying dynamics. In this paper, we present an efficient algorithm to track time-varying isosurfaces and interval volumes using isosurfacing in higher dimensions. Instead of extracting the data features such as isosurfaces or interval volumes separately from multiple time steps and computing the spatial correspondence between those features, our algorithm extracts the correspondence directly from the higher dimensional geometry and thus can more efficiently follow the user selected local features in time. In addition, by analyzing the resulting higher dimensional geometry, it becomes easier to detect important topological events and the corresponding critical time steps for the selected features. With our algorithm, the user can interact with the underlying time-varying data more easily. The computation cost for performing time-varying volume tracking is also minimized.
Fine needle aspiration cytology of adenomatoid tumour--a case report with review of literature.

Field: Medicine (Health Sciences)

Adenomatoid tumours are neoplasms of male and female genital tract with the epididymis being the most common site. They also occur in uterus, fallopian tube, and ovary. These benign tumours are asymptomatic or cause mild symptoms and a palpable mass. Fine needle aspiration of these tumours is very useful to differentiate malignant from benign lesions and helps to avoid unnecessary aggressive surgical procedures. FNAC of these benign epididymal tumours is diagnostic, rapid, reliable, conclusive and cost effective. We are reporting a case of adenomatoid tumour of epididymis in a 41 year old male patient, diagnosed by FNAC and confirmed by histopathology.
Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Established REF52 cells (rat embryo fibroblasts) completely resist stable transformation by ras oncogenes, and simian virus 40 large tumor (T) antigen collaborates with ras to convert REF52 cells to tumorigenic state. A temperature-sensitive simian virus 40 large T antigen (encoded by tsA58) allowed the T24 Ha-ras oncogene to transform REF52 cells in a temperature-dependent manner. Two thirds of the clones transformed with tsA58 and ras became arrested in G2 or late S phase when shifted to a nonpermissive temperature for T antigen stability. Thus, ras induced growth arrest rather than stable transformation in the absence of a functional collaborating oncogene. These results indicate that collaborating oncogenes can regulate cellular responses to ras and have implications regarding therapeutic strategies to control tumor cells expressing activated ras oncogenes.
An intracellular study of rubrospinal and rubro‐bulbospinal control of lumbar γ‐motoneurones

Field: Neuroscience (Life Sciences)

The actions elicited by electrical stimulation of the rubrospinal path in NR (nucleus ruber), and by stimulation of the rubro‐bulbospinal path in MesADC (mesencephalic area for dynamic control), were studied with intra‐, juxta‐ or extracellular recordings in lumbar γ‐motoneurones of cats anaesthetized with chloralose. The results were obtained during a series of experiments in which reflex effects from muscle, skin and joint afferents were also investigated. 90 cells tested with stimulation both in NR and in MesADC were classified (cf. Appelberg 1981) as dynamic (influenced from MesADC) or static (not influenced). 84 of these γ‐cells responded to stimulation in the red nucleus. The same response pattern was found for dynamic and static γ‐cells. For flexor cells, excitation was by far predominant while equal numbers of extensor cells showed excitatory and inhibitory effects. The shortest route to both static and dynamic γ‐cells was disynaptic. With stimulation of the rubro‐bulbospinal path, excitatory effects were more than twice as frequent as inhibitory effects. No clearcut difference was seen between extensor and flexor cells. The segmental latency for rubro‐bulbospinally mediated excitatory effects could be measured for only one cell, and it is tentatively suggested that the pathway to this dynamic γ‐motoneurone involves one or two interneurones more than in the rubrospinal pathway. Spontaneous activity was significantly more common among the dynamic cells, but the axonal conduction velocities of dynamic and static cells did not differ. The similarities between rubrospinal effects on α‐motoneurones and both classes of γ‐motoneurones indicate that the rubrospinal tract has the ability to coactivate α‐ and γ‐motoneurones (Granit 1955, 1979). The comparison of the properties of the population of γ‐cells classified as dynamic or static showed marked differences strengthening the reliability of the previously introduced classification method.
The Origin of the Child Healthcare in the East Coast of Sumatra, 1900s-1940s

Field: Social Sciences (Social Sciences)

This article aims to explore the issue of children’s healthcare in the context of colonial expansion on the East Coast of Sumatra. At the early of the 20th century, the birth rate, children, and maternal healthcare have become important issues in discussing health conditions in plantations in East Sumatra. It was a significant shift concerning the realm of East Sumatra plantation health and medical research due to since in the pioneering time, plantation’s medical institutions merely focused on the health of adult male coolies. The phenomenon of high rate of infant mortality in the early 20th century has become a new health problem in the East Coast of Sumatra Plantation. The plantation companies convincing to take further care of the children’s health as it will give a direct effect on plantation hygiene and population growth of the region. In the East Coast of Sumatra, children’s healthcare discourse was a proxy of the colonial capitalism interest, hygiene problems, and needs of population growth.
LIFE HISTORY STUDIES OF GONOMETA PODOCARPI AURIVILLIUS (LEPIDOPTERA: LASIOCAMPIDAE)

Field: Agricultural and Biological Sciences (Life Sciences)

There are two distinct larval generations of Gonometa podocarpi in a year; the first one is between early May to mid-October, and the second one is between the second week in November and the end of April. The last two instars cause the heaviest defoliation. The egg may be parasitized and rendered infertile by a Eupelmid of the genus Anastus. Both the larval and pupal stages of G. podocarpi are killed by Hymenopteran and Dipteran parasites which attack during the former stage. Under experimental conditions, adult moths will not mate unless the males have large enough space in which to fly after emerging from the cocoons. Adult longevity averages eight days for the males and ten days for the females.
How Unthinkable and At What Age?: Adult Opinions about the ‘Social Clock’ for Contested Behaviour by Teenagers

Field: Social Sciences (Social Sciences)

ABSTRACT The adult world's concern about youthful drug use is not only about the fact of use, but also about the age at which experimentation or regular use begins. Sometimes the explicit aim of prevention campaigns is to postpone the age of drinking or other contested behaviours, such as sexual activity. This corresponds to the concept of a 'social clock', discussed in the sociological literature, that guides when behaviours are viewed as normative; before that age the behaviour is seen as deviant or disturbing. Given studies that have claimed an upturn in teenage drug use, as well as a decrease in the age of onset of use, some have hypothesized that liberal parenting styles of the 'baby boomers' play a significant role. The present study is the first part of a larger research endeavour, which compares adults' and teens' opinions, that seeks to understand whether liberal views are prevalent among adults today, and what factors are associated with these views. In a survey of 1025 adults (aged 25 and over), we asked: 'Regardless of what the law says, at what age does it become OK' for a person to engage in 15 contested behaviours. Half the sample was asked the questions concerning a male protagonist, and half concerning a female. Results showed that between approximately one-fifth and one-half of the sample volunteered that it was 'never OK' to engage in eight of the behaviours: having sex with a girl/boyfriend, moving in with a girl/boyfriend, going to a bar with friends and drinking enough to feel the effects, buying a pack of cigarettes, smoking a cigarette, getting drunk on beer at home, becoming a regular smoker, and trying some marijuana. More 'never' responses were offered a female protagonist, particularly for smoking-related behaviours. For those who gave an age, the acceptable mean ages and their ordering were much the same for female protagonists as for males, with all but one behaviour (dating) having acceptable mean ages of initiation clustered around 18 or 19. Strong predictors of tolerance for youthful engagement in the contested behaviours included respondents' socio-demographic characteristics (e.g. being male, young, less religious), perceiving less risk from substance use, and current alcohol and marijuana use.
The effect of β_2-adrenoceptor on stretch-induced arrhythmia of isolated hearts after myocardial infarction in rats

Field: Medicine (Health Sciences)

Objective To investigate the effect of β2-adrenoceptor on stretch-induced arrhythmia of isolated hearts after myocardial infarction(MI) in rats.To evaluate the effect of β2-adrenoceptor on mechanoelectric feedback.Methods MI models were induced by ligating coronary arteries.After 8 weeks,hearts were isolated and perfused by the Langendorff instrument.36 Wistar rats were randomly divided into 4 groups:sham operation group,sham operation +ICI118.551 group,MI group and MI+ ICI118.551 group.Balloon inflation in the left ventricle of the isolated heart increased the left ventricle preload and dilated the left ventricle.After ICI118.551(10-6mol/L) was administrated through Langendorff instrument,the dilation of the left ventricle was carried out.The monophasic action potential(MAP) of the anterior left ventricle wall of rat hearts was recorded.The effect of stretching was observed for 30s,including MAP duration(MAPD),50% and 90% MAP duration(MAPD50,MAPD90),premature ventricular beats(PVB) and ventricular tachycardia(VT).Results After the stretch,MAPD,MAPD50,and MAPD90 were shortened in both MI group and sham operation group,but it was significant in MI group.After administration of ICI118.551,MAPD,MAPD50,and MAPD90 were still shortened in sham operation group(P0.05),but there was no difference in MI group(P〈0.05).After the stretch,the incidence rate of SIA in MI group was higher than that in sham operation group(22.44% vs 10.34%,P0.05).After administration of ICI118.551,the incidence rate of SIA decreased in sham operation group,but there was no statistical difference(P〉0.05);yet it decreased obviously in MI group(P0.01).Conclusion β2-adrenoceptor might be involved in mechanoelectric feedback process.