jimnoneill/paper-to-field-training huggingface dataset:
Ferroptosis in Spinal Cord Injury: Research Progress and Novel Insights

Field: Neuroscience (Life Sciences)

ABSTRACT Spinal cord injury (SCI) is a severe condition affecting the central nervous system that often leads to varying degrees of motor and sensory impairment. Acute primary SCI is often managed with early surgical intervention; however, secondary SCI generally has a poor prognosis owing to the lack of effective drug therapy, complex pathophysiological processes, and inherent challenges of neural repair. Ferroptosis, a novel form of programmed cell death, is characterised by oxidative damage resulting from iron‐mediated accumulation of reactive oxygen species (ROS) and lipid peroxidation (LPO) within cells. This type of cell death is prevalent in various pathological processes. Although research on ferroptosis in SCI is still emerging, some inhibitors (such as target proteins and natural compounds) have shown promising results in preclinical studies. Targeting ferroptosis may be a potential strategy for treating SCI. This paper reviews the current state of research on ferroptosis in SCI by analysing recent literature and proposes future research directions, aiming to provide new insights into SCI treatment.
Observations on the wall flora of Kyustendil (Bulgaria)

Field: Agricultural and Biological Sciences (Life Sciences)

The wall fora of two buildings, the Historical Museum and the Dervish Bath (16t h century), in the central part of the town of Kyustendil was investigated. Previous data for the same area of study has shown that the wall flora includes more than 120 species of vascular plants. This study presents data from five years of observations (2005-2010). During the last three years the town administration has conducted an urban maintenance program, including old town walls. These activities changed the condition of the walls to specific vertical habitats. Restored and cleaned walls present a unique opportunity for spontaneous colonization by the diversified surrounding landscape flora. The present study shows the dynamics of species diversity and analyzes the conformities and trends about the origin of this process. Most of them are associated with wall characteristics such as ferns (Asplenium trichomanes and Asplenium rutamuraria) and typically xerophytes (Arenaria serpyllifolia). New species such as Acer negundo and Catalpa speciosa, were located on the roof of the buildings. Trees negatively affect a walls' structure and present a basic problem for the preservation of walls. Some are accepted as an additional ornamental element and contribute to the complete perception of architectural and historical sites especially mosses, ferns and flowering plants (e.g. Cymbalaria muralis, Sedum hispanicum, Chelidonium majus, Oxalis spp., Trifolium spp.). The total representation of alien species on the studied walls is 17% and the most common families among the alien species are Asteraceae, Brassicaceae, Poaceae, Fabaceae, and Oxalidaceae, a few of them are also highly invasive (e.g. Ailanthus altissima, Acer negundo, Oxalis spp.). On the basis of the previous and present study the present state of the wall was estimated and recommendations were made about maintaining the old walls and their neighboring area.
Johnson County - 387, 1972-1974

Field: Social Sciences (Social Sciences)

The Regions and Locals series (1968-1982) contains limited amounts of correspondence, financial records, tax forms, and organizational materials from local units of PATCO. In addition to region-specific correspondence, this series contains materials devoted to the regional seminars organized by PATCO to educate its membership (1974-1976) and a regional public relations manual to help local union leaders deal effectively with the press in their areas. Several sections of this series deal indirectly with the 1981 Strike, including several folders of region correspondence (1981-1982). See Series XI: Regions and Locals finding aid for complete description.
Supplementary Materials and Methods from A Novel Regulatory Mechanism of Pim-3 Kinase Stability and Its Involvement in Pancreatic Cancer Progression

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>PDF - 30KB, Supplementary Materials an Methods including antibody, patient and tissue samples, and scoring of TCTP, and a Pim-3 in human pancreatic cancer tissues section.</p>
From Dürer’s Angel to Harlow’s Monkey

Field: Arts and Humanities (Social Sciences)

Melancholy is a product of the composition and recomposition of bodies, with the smooth spectrum of bodily affect territorialized into a striated repertoire of characteristic zones that are classified into emotions. It is impossible to imagine a body experiencing an emotional state without knowing what an emotion looks like in the first place. This chapter explores melancholy representation to determine what sort of consistency bodily posture might provide for a melancholy assemblage. Drawing on Albrecht Dürer’s engraving Melencolia I (1514), Isaac Oliver’s oil painting Edward Herbert, First Baron Herbert of Cherbury (1614), and Bas Jan Ader’s silent short film I’m Too Sad to Tell You (1970), the chapter examines the extent to which the pictorial convention of melancholy posture produces the viewer’s experience of affective recognition in each image. It also considers what sort of self-relation is transmitted by the posture of propping and how the visual register is complicated by the haptic circuit of self-support and self-touch implicit in propping.
A novel gene expression system using transcription amplification to examine cdk2‐associated cell cycle regulator role in cancer cell apoptosis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

In order to improve understanding of the contribution of p27kip1, a cyclin‐dependent kinase 2 (cdk2) regulator to growth inhibition in prostate cancer cells, we have modulated p27 expression using a new two‐step transcription amplification system. p27 expression usually is associated with G1/S arrest through cdk2 inhibition, and downregulated during prostate cancer progression by its increased targeting for ubiquitin proteasome degradation. We selected a degradation‐resistant mutant (T187M/P188I;p27mt), hypothesized to be more effective in inhibiting tumor growth. We adapted an adenoviral‐based transcriptional amplification system containing a prostate‐specific promoter (PSE‐BC) driving a GAL4‐VP16 activator, which in turn activates expression of a bidirectional Luc/p27 (or p27mt) cassette. p27mt showed higher growth inhibition, with ~80% tumor growth reduction in vivo, and the main mechanism of growth inhibition was through apoptosis induction. Using a qPCR array, we observed several proapoptotic gene expression changes, including death receptors/ligands, caspases, and TP73 upregulation. Prosurvival changes also were observed, for example, Birc8 upregulation. Further optimization of this system is in progress and includes combination vectors for enhanced antitumor effectiveness, including cell cycle regulators (p12/cdk2ap1) and antisurvival strategies (shHer2).
Sustainability reporting challenges in developing countries: towards management perceptions research evidence-based practices

Field: Business, Management and Accounting (Social Sciences)

Purpose The purpose of this paper is threefold. First, it aims to identify managerial perceptions-based research determinants of sustainability reporting. Second, it sets out to evaluate the impact of the Global Reporting Initiative (GRI) efforts in increasing SR in developing countries. Third, the researcher argues for the adoption of management perceptions research evidence-based practices (EBP) to address SR challenges in developing countries. Design/methodology/approach The study was undertaken using a desk-based review of management perceptions-based research literature on the determinants of SR. The impact of GRI efforts in increasing adoption of SR was undertaken through both desk-based research and descriptive analysis of data obtained from the GRI database from 2014 to 2019 relating to 107 developing countries. The call for the adoption of management perceptions research EBP is based on a critical analysis of both the management perceptions of the determinants of SR research and evaluation the impact of GRI efforts to increase SR in developing countries. Findings Training, legislation, issuing of guidance, stakeholder pressure, awareness campaigns, market and public pressure were identified as some of the determinants of SR. The evaluation of the impact of GRI efforts shows they had limited impact on increasing SR in developing countries. Research needed to adopt management perceptions research EBP is identified. Research limitations/implications This study is conceptual. Management perceptions-based research is needed in more developing countries to better understand the determinants of SR and identify the most effective policies or practices to address related challenges. Originality/value The findings contribute to the calls to make academic research more relevant to policy formulation. In particular, the proposal for research needed to inform EBP adoption to address SR challenges in developing countries is new.
Resilience and student wellbeing in Higher Education: A theoretical basis for establishing law school responsibilities for helping our students to thrive

Field: Social Sciences (Social Sciences)

There is widespread concern for the mental wellbeing of our students. We argue that, while resisting the neoliberal tendencies that contribute to this, we have a responsibility for helping our students to thrive. Rooted in a theory of positive psychology: self determination theory, we present methods which may help us in this endeavour. These include our approaches to marketing and recruitment, curriculum design, assessment and feedback, experiential learning and developing a safe learning environment. We suggest how addressing these areas of our practice may assist students to develop their competence, and to experience autonomy and relatedness during their programmes of learning. In so doing we provide sources which underpin our arguments and which, we hope, will encourage a debate across European law faculties on this important topic.
Tac2Motion: Contact-Aware Reinforcement Learning with Tactile Feedback for Robotic Hand Manipulation

Field: Computer Science (Physical Sciences)

This paper proposes Tac2Motion, a contact-aware reinforcement learning framework to facilitate the learning of contact-rich in-hand manipulation tasks, such as removing a lid. To this end, we propose tactile sensing-based reward shaping and incorporate the sensing into the observation space through embedding. The designed rewards encourage an agent to ensure firm grasping and smooth finger gaiting at the same time, leading to higher data efficiency and robust performance compared to the baseline. We verify the proposed framework on the opening a lid scenario, showing generalization of the trained policy into a couple of object types and various dynamics such as torsional friction. Lastly, the learned policy is demonstrated on the multi-fingered robot, Shadow Robot, showing that the control policy can be transferred to the real world. The video is available: https://youtu.be/poeJBPR7urQ.
Third-order &#x03A3;&#x0394; modulator with 61-dB SNR and 6-MHz bandwidth consuming 6 mW

Field: Engineering (Physical Sciences)

This low-power sigma-delta modulator targets the DVB-H requirements and achieves about 10 bit with 6-MHz signal band and a FoM of 0.59 pJ/conversion. The used scheme is a multi-bit third order modulator that, with suitable topological modification, enables using two op-amps and enjoying a swing reduction at the quantizer input. The area of the circuit, fabricated with a 0.18-μm analog CMOS technology, is 0.32 μm 2 . The nominal supply voltage is 1.8 V and the clock frequency is 96 MHz (OSR = 8). Experimental measurements confirm the behavioral study made accounting for the op-amps limitations.
The effects of teacher talk on students' oral productions

Field: Social Sciences (Social Sciences)

The present study is a brief personal enquiry into the teaching and learning of EFL in the classroom with an orientation to action and personal professional development. It focuses on teacher talk, making special emphasis on questions, as well as on students' resulting oral productions. The research contains samples of empirical data, which include their interpretations in the light of relevant research literature, and a more personal overall reflection of the teaching practice. Both the analysis and the reflections derive to a large extent from the self-observation paper 1 (SO1) and the Practicum portfolio (PP) developed within the TED Masters Degree practicum stages
A novel deep learning based intrusion detection system for the IoT-Cloud platform with blockchain and data encryption mechanisms

Field: Computer Science (Physical Sciences)

The Internet of Things (IoT) integrated Cloud (IoT-Cloud) has gotten much attention in the past decade. This technology’s rapid growth makes it even more critical. As a result, it has become critical to protect data from attackers to maintain its integrity, confidentiality, protection, privacy, and the procedures required to handle it. Existing methods for detecting network anomalies are typically based on traditional machine learning (ML) models such as linear regression (LR), support vector machine (SVM), and so on. Although these methods can produce some outstanding results, they have low accuracy and rely heavily on manual traffic feature design, which has become obsolete in the age of big data. To overcome such drawbacks in intrusion detection (ID), this paper proposes a new deep learning (DL) model namely Morlet Wavelet Kernel Function included Long Short-Term Memory (MWKF-LSTM), to recognize the intrusions in the IoT-Cloud environment. Initially, to maintain a user’s privacy in the network, the SHA-512 hashing mechanism incorporated a blockchain authentication (SHABA) model is developed that checks the authenticity of every device/user in the network for data uploading in the cloud. After successful authentication, the data is transmitted to the cloud through various gateways. Then the intrusion detection system (IDS) using MWKF-LSTM is implemented to identify the type of intrusions present in the received IoT data. The MWKF-LSTM classifier comes up with the Differential Evaluation based Dragonfly Algorithm (DEDFA) optimal feature selection (FS) model for increasing the performance of the classification. After ID, the non-attacked data is encrypted and stored in the cloud securely utilizing Enhanced Elliptical Curve Cryptography (E2CC) mechanism. Finally, in the data retrieval phase, the user’s authentication is again checked to ensure user privacy and prevent the encrypted data in the cloud from intruders. Simulations and statistical analysis are performed, and the outcomes prove the superior performance of the presented approach over existing models.
Characterization of the multiple forms of monoamine oxidase from chronic schizophrenic sera.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Either half or one hour incubation time was enough to get a constant production of benzylaldehyde and were proportional to the amount of enzyme added. The optimal temperature of MAO, I, II, III, IV are 60 degrees, 37 degrees, 60 degrees, 45 degrees, and 37 degrees C respectively, and they follow Arrhenius equation until these optimal temperatures. Each form have optimal pH depends on substrate concentration used and the buffer used. These forms were shown to be inhibited by high substrate concentration with formation of inactive enzyme-amine complex, whereas butyl- and octylamine was found to be competitive inhibitors. Isoniazid inhibit MAO II, III, IV and V forms in a non competitive fashion, whereas MAO I inhibited competitively with respect to the substrate. Semicarbazid inhibit MAO I. III, IV and V forms in a non competitive fashion, whereas MAO II inhibited competitively with respect to the substrate.
Ions in the Thermosphere of Exoplanets: Observable Constraints Revealed by Innovative Laboratory Experiments

Field: Physics and Astronomy (Physical Sciences)

Abstract With the upcoming launch of space telescopes dedicated to the study of exoplanets, the Atmospheric Remote-Sensing Infrared Exoplanet Large-survey (ARIEL) and the James Webb Space Telescope (JWST), a new era is opening in exoplanetary atmospheric explorations. However, especially in relatively cold planets around later-type stars, photochemical hazes and clouds may mask the composition of the lower part of the atmosphere, making it difficult to detect any chemical species in the troposphere or understand whether there is a surface or not. This issue is particularly exacerbated if the goal is to study the habitability of said exoplanets and search for biosignatures. This work combines innovative laboratory experiments, chemical modeling, and simulated observations at ARIEL and JWST resolutions. We focus on the signatures of molecular ions that can be found in upper atmospheres above cloud decks. Our results suggest that along with H 3 O + could be detected in the observational spectra of sub-Neptunes based on a realistic mixing ratio assumption. This new parametric set may help to distinguish super-Earths with a thin atmosphere from H 2 -dominated sub-Neptunes to address the critical question of whether a low-gravity planet around a low-mass active star is able to retain its volatile components. These ions may also constitute potential tracers to certain molecules of interest, such as H 2 O or O 2 , to probe the habitability of exoplanets. Their detection will be an enthralling challenge for the future JWST and ARIEL telescopes.
Surfaces and thin films studied by picosecond ultrasonics. Progress report, December 1, 1989--November 30, 1992

Field: Physics and Astronomy (Physical Sciences)

This research is the study of thin films and interfaces via the use of the picosecond ultrasonic technique. In these experiments ultrasonic waves are excited in a structure by means of a picosecond light pulse (``pump pulse``). The propagation of these waves is detected through the use of a probe light pulse that is time-delayed relative to the pump. This probe pulse measures the change {Delta}R(t) in the optical reflectivity of the structure that occurs because the ultrasonic wave changes the optical properties of the structure. This technique make possible the study of the attenuation and velocity of ultrasonic waves up to much higher frequencies than was previously possible (up to least 500 GHz). In addition, the excellent time-resolution of the method makes it possible to study nanostructures of linear dimensions down to 100 {Angstrom} or less by ultrasonic pulse-echo techniques. 25 refs.
Platelet antiaggregation after an acute coronary syndrome: what about the elderly?

Field: Medicine (Health Sciences)

Journal Article Platelet antiaggregation after an acute coronary syndrome: what about the elderly? Get access Kurt Huber Kurt Huber 3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminenhospital, and Sigmund Freud University, Medical Faculty, Vienna, Austria Corresponding author. Tel: +43 1 49150 2301,Fax: +43 1 49150 2309, Email: kurt.huber@meduniwien.ac.at https://orcid.org/0000-0003-1695-3378 Search for other works by this author on: Oxford Academic PubMed Google Scholar European Heart Journal, Volume 43, Issue 48, 21 December 2022, Pages 5045–5046, https://doi.org/10.1093/eurheartj/ehac405 Published: 11 November 2022
720 Characterization of fatigue damage development in stitched CF/NY6 orthotropic laminates

Field: Engineering (Physical Sciences)

This paper describes the investigation of thermoelastic effect and damage process in carbon fiber reinforced thermoplastic composite laminates through thermoelastic stress analysis. Symmetrically orthotropic model laminate specimens having 4-layers of carbon fibers using spread tows and Nylon-6 were conducted to tension-tension fatigue tests. In order to estimate the thermal conduction effects due to thermoelastic effects generated in the sub-layer in a specimen under fatigue test, the measurement employed all of delayed phase emission via FFT processing the data recorded by Lock-in therrnograpy. Evidently, the processed thennoelastic images (TSA images) brought the information from the second or third layers. Thermoelastic damage analysis (TDA) between two TSA images, proposed by one of the authors, detected splitting and/or transverse matrix cracks in the notched root of a specimen and TDA information also showed a possible quantitative estimation of damage development.
Education effectiveness Comparison between Face to Face lectures and Online lectures

Field: Social Sciences (Social Sciences)

The paper proposed a most effective lecture style based on accumulated educational data in the last 3 years. The education data includes all student scores of short tests, reports, final tests, access logs to online e-learning system, and student answers to questionnaires. As a result, in subjects that fit the drill learning style such as "IT Introduction", the educational effectiveness of online lectures becomes high, but needed student mental consultations. In the subjects that take conceptual knowledge and skills, the educational effectiveness of online lectures becomes low. We confirmed that the online materials should be on-demand learning materials including short movies and short tests, not live streaming materials.
Lifestyle Medicine: The Health Promoting Power of Daily Habits and Practices

Field: Health Professions (Health Sciences)

There is no longer any serious doubt that daily habits and actions profoundly affect both short-term and long-term health and quality of life. This concept is supported by literally thousands of research articles and incorporated in multiple evidence-based guidelines for the prevention and/or treatment of chronic metabolic diseases. The study of how habits and actions affect both prevention and treatment of diseases has coalesced around the concept of “lifestyle medicine.” The purpose of this review is to provide an up-to-date summary of many of the modalities fundamental to lifestyle medicine, including physical activity, proper nutrition, weight management, and cigarette smoking cessation. This review will also focus specifically on how these modalities are employed both in the prevention and treatment of chronic diseases including coronary heart disease, diabetes, obesity, and cancer. The review concludes with a Call to Action challenging the medical community to embrace the modalities of lifestyle medicine in the daily practice of medicine.