jimnoneill/paper-to-field-training huggingface dataset:
[Examination of ERCC1 expression in lung cancer patients treated with platinum-based chemotherapy].

Field: Medicine (Health Sciences)

Platinum-based chemotherapies are widely used in the treatment of lung cancer. However, little is known about their effect in the expression of certain tissue biomarkers. We have studied the ERCC1 (excision repair cross-complementation group 1) expression in tissue samples of patients treated with neoadjuvant chemotherapy. Fifty lung cancer tissue blocks of 25 patients (15 males, 10 females) were studied. They included 25 bronchoscopic biopsies (14 squamous cell carcinomas and 11 adenocarcinomas) together with their corresponding surgical biopsies after neoadjuvant chemotherapy. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissues to study the expression of ERCC1. Staining scores (0-300) were calculated by multiplying the percentage of positive tumor cells (0-100) by the staining intensity (0-3). All but one bronchosopic squamous cell carcinoma tissues (13/14) expressed ERCC1. Four of these cases became negative after neoadjuvant therapy, and in 8 cases the level of expression decreased. In the adenocarcinoma group all but one bronchosopic tissues (10/11) expressed ERCC1. Six of these cases became negative after neoadjuvant therapy, and in 4 cases the level of expression decreased. Comparison of staining scores before and after chemotherapy revealed more pronounced decrease in adenocarcinomas and in female patients. There was no newly expressed ERCC1-positive case in the surgical biopsy group. The results of the present study suggest that platinum-based chemotherapy affects the expression of tissue biomarker (ERCC1) which may have predictive value, and probably induces a selection of tumor cells with more aggressive phenotype. This knowledge might be of importance when designing treatment protocols for non-small cell lung cancer patients.
CS-14 Prolonged antimalarial treatment is associated with increased risk for elevated myocardial biomarkers in systemic lupus erythematosus

Field: Medicine (Health Sciences)

Background

Antimalarial (AM)-induced cardiomyopathy (AMIC) has been rarely reported in systemic lupus erythematosus (SLE). However, given the large number of patients treated, it seems possible that AMIC is under-recognized and may run undiagnosed as an ill-defined heart failure syndrome. Specific cardiac biomarkers may identify patients at risk. We sought to investigate the prevalence and associated factors for such biomarkers in SLE.

Methods

One hundred sixty-eight consecutive patients (153 females) attending the a large lupus clinic, without past history of cardiac disease (heart failure, coronary artery disease, valvulopathy etc.) and/or pulmonary hypertension, were enrolled. None had chest pain or electrocardiographic (ECG) abnormalities suggestive of acute coronary syndrome. High-sensitivity cardiac troponin I (cTnI) and B-natriuretic peptide (BNP) were measured simultaneously in serum and plasma samples, respectively. Patients were categorized according to normal or abnormal BNP and/or cTnI. For the assessment of the impact of AM duration on abnormal cardiac biomarkers, patients were divided in two groups according to the median duration of use, which was calculated at 5.6 years in the current cohort. Statistical analysis was performed with SAS 9.0 software; p<0.05 was considered significant.

Results

Sixteen patients (9.5%) had elevated BNP and/or cTnI. Compared to subjects with normal biomarkers, they were older, had longer disease and AM use duration and more frequently persistent creatine phosphokinase (CPK) elevation (table 1). Multivariable regression analysis showed prolonged AM treatment (>5.6 years) and persistent CPK elevation to be important predictors for elevated cardiac biomarkers [HR=5.43, 95% CI=1.14 to 25.9, p=0.034 and HR=4.62, 95% CI=1.22 to 17.51, p=0.024, respectively]. Two patients were diagnosed with AMIC on endomyocardial biopsy; both had CPK and BNP/cTnI elevation.

Conclusions

Approximately 9% of SLE patients had elevated myocardial biomarkers, in the absence of prior cardiac disease or pulmonary arterial hypertension. Prolonged AM therapy and persistent CPK elevation conferred an increased risk for abnormal BNP and cTnI, which might predict AMIC.
4-1BB Ligand-Mediated Imbalance of Helper 17 T Cells and Regulatory T Cells in Patients with Allergic Asthma

Field: Immunology and Microbiology (Life Sciences)

OBJECTIVES: To investigate the presence of 4-1BB ligand (4-1BBL) in the peripheral blood of patients with allergic asthma and evaluate its role in controlling the balance between helper 17 T (T h 17) and regulatory T (T reg ) cells. METHODS: Soluble 4-1BBL (s4-1BBL) was quantified by enzyme-linked immunosorbent assay in plasma from patients with asthma ( n = 45) and from healthy control subjects ( n = 35). The proportion of monocytes positive for membrane-bound 4-1BBL (m4-1BBL) was determined by flow cytometry. Peripheral blood mononuclear cells from patients with asthma were incubated with anti-4-1BB monoclonal antibody in vitro. Concentrations of interleukin (IL)-17 and transforming growth factor (TGF)-β 1 in the culture supernatant were analysed. RESULTS: Plasma s4-1BBL concentrations and the proportion of m4-1BBL-positive monocytes were significantly lower in patients with asthma than in control subjects. The culture supernatant concentration of TGF-β 1 was increased and that of IL-17 was decreased by incubation with anti-4-1BB monoclonal antibody. CONCLUSIONS: Both soluble and membrane-bound 4-1BBL were reduced in patients with allergic asthma compared with control subjects. 4-1BBL/4-1BB signalling may play an important role in allergic asthma by regulating the T h 17/T reg balance.
Protecting Whiteness

Field: Social Sciences (Social Sciences)

Focusing on intergroup anti-non-White bias in the criminal justice system, little attention is given to how Whites may additionally be protected from negative police treatment. This study examines intragroup bias via perceived suspect phenotypic racial stereotypicality (e.g., how strongly members possess physical features typical of their racial group) on severity of police use of force. It is hypothesized that the Whiter one appears, the more the suspect will be protected from police force. Internal use of force case files from a large police department were coded for severity of police force, and suspects’ booking photographs were scored for phenotypic racial stereotypicality. Regression analyses confirmed that police used less force with highly stereotypical Whites, and this protective effect was stronger than the effect for non-Whites. Results suggest that intragroup bias is a protective factor for Whites, but not for non-Whites, providing an additional route through which racial disparities in policing operate.
Sinus node function in the denervated human heart. Effect of digitalis.

Field: Medicine (Health Sciences)

Evaluation of sinus node function was performed in 5 patients with an intact cardiac autonomic nervous system (group I), and in 8 patients with a transplantated, denervated heart (group 2). After baseline data were recorded, the electrophysiological studies were repeated in all group I patients and in 6 of the 8 group 2 patients, 45 to 60 minutes after the administration of digoxin 1.25 mg intravenously. Baseline cycle length, sinus node recovery time, and sinoatrial conduction time were significantly shorter in the transplanted heart than in those with intact autonomic innervation, but correction of the sinus node recovery time and sinoatrial conduction time for heart rate abolished these differences. Digoxin produced a small increase in cycle length, sinus node recovery time, and sinoatrial conduction time which did not reach statistical significance in this small study group of patients with innervated hearts. In the denervated, transplanted patients, no change in cycle length occurred after digoxin in any patient. The sinus node recovery time was unaffected by glycoside administration in 3 of 6 patients, while the sinoatrial conduction time was unchanged in 4 of 6. In one group 2 patient, digoxin produced first degree sinoatrial node exit block, and in a second patient, 2:1 sinoatrial nodal exit block developed. The mechanisms responsible for these effects in the denervated heart are not clear.
Long-Term Efficacy and Safety of Inotersen for Hereditary Transthyretin Amyloidosis: NEURO-TTR Open-Label Extension 2-Year Update (S27.008)

Field: Medicine (Health Sciences)

May 7, 2019April 9, 2019Free AccessLong-Term Efficacy and Safety of Inotersen for Hereditary Transthyretin Amyloidosis: NEURO-TTR Open-Label Extension 2-Year Update (S27.008)Thomas Brannagan, Marcia Waddington Cruz, Annabel K. Wang, Michael J. Polydefkis, Peter J. Dyck, Sami Khella, Violaine Plante-Bordeneuve, … Show All … , John L. Berk, Fabio Barroso, Giampaolo Merlini, Isabel Conceição, Steven G. Hughes, Jesse Kwoh, Shiangtung W. Jung, Spencer Guthrie, Michael Pollock, Merrill D. Benson, Morie Gertz, and Teresa Coelho Show FewerAuthors Info & AffiliationsApril 9, 2019 issue92 (15_supplement)https://doi.org/10.1212/WNL.92.15_supplement.S27.008 Letters to the Editor
Trend in the Containerization Development of Tianjin Port Based on Logistic Growth Model

Field: Decision Sciences (Social Sciences)

This paper offers a simulation of the development track of Tianjin Port from the perspective of the similarities between port development and population model.The simulation shows that, as the midpoint of the growth trajectory is passed, it is forecast that the development of Tianjin Port will gradually slow down.The competitiveness of Tianjin Port is understood in the comparison with other listed port group companies in China.The study shows that the overall competitiveness of Tianjin Port is strong, but it still has space for further development in management efficiency and hinterland transportation network construction.
Results of culture of Mycoplasma and drug resistance

Field: Medicine (Health Sciences)

Objective To review the results of culture of mycobacterium and drug resistance test. Methods Mycoplasma was cultured and drug sensitibity test was conducted. Results Totally 2 395 cases were detected and 1255 positives were detected with a positive rate of 52.40%,including 994 cases positive for Ureaplasma urealyficum(Uu)(79.20%),26 cases positive for Mycoplasma hominis(Mh)(2.07%);235 cases positive for two mixed mycoplasma infection(18.73%).Mycoplasma was sensitive to doxycycline(88.6%) and minocycline(83.7%). Conclusion Antibiotics be used based on the results of drug sensitivity test to enhance cruative effect.
On the linguistic properties of formulaic speech

Field: Arts and Humanities (Social Sciences)

In the study of oral-formulaic performance the formula has always been understood as playing a pivotal role (Lord 1960, Foley 1995). But although it is clearly a linguistic unit, the technical study of formulae by linguists has been slight. This paper intends to remedy this lack by proposing some linguistic theories as to the nature of the formula. They will take the form of formal and testable proposals. By formal I mean mathematically modelled.//
Palladium-Catalyzed Remote meta-C–H Bond Deuteration of Arenes Using a Pyridine Template

Field: Chemistry (Physical Sciences)

Palladium-catalyzed meta-selective C-H deuteration of a series of substrates, including phenylacetic acids, hydrocinnamic acid, benzylphosphonate, benzylsulfonate, and benzyl and phenyl ethyl alcohol ester, is developed by using a pyridine-based directing template. The template is installed into the substrate through a practical ester linkage. Under mild reaction conditions, a variety of phenylacetic acids containing alkyl, methoxyl, and halo substituents are compatible in the reaction, resulting in high levels of D-incorporation at the meta position.
IMPLEMENTASI MEDIA MOTARO BERBASIS TPACK PADA PEMBELAJARAN IPS UNTUK MENINGKATKAN MOTIVASI BELAJAR PESERTA DIDIK

Field: Social Sciences (Social Sciences)

The purpose of this research is to improve students learning motivation by using TPACK-based MOTARO media in social studies subjects. The type of research method is classroom research which is carried out for 2 cycles. Data analysis was carried out through interviews, observations, questionnaires and documentation to see the level of students learning motivation after using TPACK-based MOTARO media in social studies subjects. The results of observing student motivation obtained a score percentage of 71%, including the high motivation category, and at the second meeting using media, the average class obtained a score percentage of 82%, including the very high motivation category. Then it was obtained through a learning motivation questionnaire that students got the class average score at the first meeting with a percentage of 74% which was included in the high motivation category and at the second meeting there was an increase with the class average with a percentage of 88% which was included in the very high motivation category. So, from the results of the questionnaire and observations obtained, the implementation of TPACK-based MOTARO media in social studies subjects can increase students learning motivation.
Vertical and Fore-Aft Seat-to-Head Transmissibility Response to Vertical Whole Body Vibration: Gender and Anthropometric Effects

Field: Engineering (Physical Sciences)

In this study, the biodynamic responses to vertical vibration are investigated in terms of seat-to-head vibration transmissibility (STHT) to study the effects of gender and eleven different anthropometric parameters on the STHT responses in the vertical and fore-aft directions. The STHT response of 31 male and 27 female human subjects were measured under three levels of vertical vibration (0.25, 0.50 and 0.75 m/s 2 rms acceleration) in the 0.50 to 20 Hz range, while seated without a back support and against a vertical back support with hands on a steering wheel. The results showed that the vertical and fore-aft STHT responses of the two genders were distinctly different. The primary resonance frequency of the male subjects was higher than the female subjects, while the peak magnitudes were comparable. The male subjects showed relatively greater softening effect, i.e. decrease in the primary resonance frequency with increase in excitation magnitude, as compared to the female subjects, irrespective of the sitting condition. The body mass revealed strong effect on both the male and female STHT responses. The primary resonance frequency of heavier subjects was lower than that of the lighter subjects, while the peak magnitude was higher for the heavier subjects. The male subjects showed significantly higher primary resonance frequency than the female subjects, even when comparable body mass, BMI and lean body mass were considered. The vertical STHT response of the two genders with same body fat mass was very similar for the sitting and excitation conditions considered in the study, particularly up to 10 Hz.
Input and Output Fields in Systems Used for the Investigation and Analysis of Food Poisoning

Field: Health Professions (Health Sciences)

Major challenges in recent food poisoning investigations include determination of whether the source of the food poisoning toxins was food, water, or an infection of human origin, and the efficiency of detection in sporadic food poisoning. The importance of symptom definitions has also been noted, and their underlying investigation categories need immediate reappraisal. The provision of pertinent information to the mass media in order to obtain the understanding and cooperation of local residents is another important topic.A system capable of handling all these challenges simultaneously is a data processing and information retrieval system centered around a database, aggregation, and statistical analysis. Such systems are intended to promptly and accurately determine the causes of food poisoning and prepare reports and press release materials. This paper reveals the input and output fields for that schema and architecture.
Integration of energy storage systems for marine applications

Field: Energy (Physical Sciences)

This final year project report presents the different power converter topologies for grid integration of energy storage system. The motivation behind this research is to investigate the types of power converter topologies that are most well optimized for the marine applications. The report will be split into 5 different sections namely, introduction & background, literature review, understanding the operation, analyzing the criteria, comparison and evaluation between the various topologies, scoring system, and conclusion. The introduction will start off by providing the background information on the needs for ESS and the motivation behind it. It will also discuss the scope of work and task deliverable for the project. This section will also briefly touch upon the power generation on ships. Literature review section will discuss the fundamentals of different types of power converters that are available in the market which can be used for the integration of ESS for marine applications as well as the power system interface consideration for the project. The operation principle section will be explaining the operation principle of the converters, inverters and the transformer. With the understanding how these devices operate, this will aid in making comparisons and give a better understanding of what will be the better topology. The different criteria were analyzed and followed by the comparison and finally providing the ranking of the most suitable topologies among the proposed ones.
Barriers to participation of Aboriginal people in cancer care: communication in the hospital setting

Field: Health Professions (Health Sciences)

Key areas for the attention of health service providers in communicating and caring for Aboriginal people in the hospital setting include culturally sensitive and empathetic personal contact, acknowledgement and respect for Aboriginal family structures, culture and life circumstances, an understanding of the significant role of non-verbal communication, and the importance of history, land and community. Employing more Aboriginal health workers in hospitals, and allowing Aboriginal people to participate at a decision-making level in hospitals is likely to improve Aboriginal people's access to cancer treatment, and would be important symbols of progress in this area.
CDK1 controls CHMP7-dependent nuclear envelope reformation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Through membrane sealing and disassembly of spindle microtubules, the Endosomal Sorting Complex Required for Transport-III (ESCRT-III) machinery has emerged as a key player in the regeneration of a sealed nuclear envelope (NE) during mitotic exit, and in the repair of this organelle during interphase rupture. ESCRT-III assembly at the NE occurs transiently during mitotic (M) exit and is initiated when CHMP7, an ER-localised ESCRT-II/ESCRT-III hybrid protein, interacts with the Inner Nuclear Membrane (INM) protein LEM2. Whilst classical nucleocytoplasmic transport mechanisms have been proposed to separate LEM2 and CHMP7 during interphase, it is unclear how CHMP7 assembly is suppressed in mitosis when NE and ER identities are mixed. Here, we use live cell imaging and protein biochemistry to examine the biology of these proteins during M-exit. Firstly, we show that CHMP7 plays an important role in the dissolution of LEM2 clusters that form at the NE during M-exit. Secondly, we show that CDK1 phosphorylates CHMP7 upon M-entry at Ser3 and Ser441 and that this phosphorylation reduces CHMP7’s interaction with LEM2, limiting its assembly during M-phase. We show that spatiotemporal differences in the dephosphorylation of CHMP7 license its assembly at the NE during telophase, but restrict its assembly on the ER at this time. Without CDK1 phosphorylation, CHMP7 undergoes inappropriate assembly in the peripheral ER during M-exit, capturing LEM2 and downstream ESCRT-III components. Lastly, we establish that a microtubule network is dispensable for ESCRT-III assembly at the reforming nuclear envelope. These data identify a key cell-cycle control programme allowing ESCRT-III-dependent nuclear regeneration.
High frequency ventilation in acute respiratory distress syndrome: a case report

Field: Medicine (Health Sciences)

Acute Respiratory Distress Syndrome is a common entity thataffects patients with serious conditions and has a high mortalityrate. It was published ten years ago that pulmonary protectiveventilation, with low tidal volumes and high respiratory frequencies,would have a positive impact on the mortality rates of patientswith acute respiratory distress syndrome. Hence, the interest inhigh frequency ventilation has risen since it is as a safe and effectiveway to provide protective ventilation. This is a case report of apatient with congenital acute lymphoid leukemia, who progressedwith severe sepsis and acute respiratory distress syndrome andbenefited from high frequency ventilation.
Active vibration suppression of a flexible structure using smart material and a modular control patch

Field: Engineering (Physical Sciences)

This paper presents experimental results of vibration suppression of a flexible structure using smart materials and a miniaturized digital controller, called the modular control patch (MCP). The MCP employs a TI-C30 digital signal processor and was developed by TRW for the United States Air Force for future space vibration control. In this research, the MCP is used to implement different control algorithms for vibration suppression of a cantilevered aluminium beam. The beam is equipped with smart sensors and actuators, and both are made of piezoceramics. Positive position feedback (PPF) control, strain rate feedback (SRF) control and their combinations were implemented. Experiments found that PPF control is most effective for single-mode vibration suppression, and two PPF filters in parallel are most effective for multimode vibration suppression. Experiments also demonstrated the capacity of smart material being used as sensors and actuators for vibration suppression. The MCP was shown to be capable of implementing various real-time control laws.
The war for talent: selection skills for busy managers

Field: Business, Management and Accounting (Social Sciences)

Whatever the job opportunities immediately on offer, appointing the right people generally means appointing bright people. Those with positive attitudes will be more likely to exceed their immediate job brief, grow within the organisation concerned and make a long-term contribution to its bottom line. Researchers have thus generally agreed that top performing organisations pay particular attention to recruiting good people.1 One study explored the distinguishing traits of those organisations that make the transition from being merely good in their field to sustained greatness.2 Among their key attributes was a special emphasis on recruiting the right people, generally defined by their overall attitude. Indeed, the drive to recruit and retain the best has been dubbed 'The war for talent'.3 In the struggle to get the right people on board, the interview remains one of the most common tools of selection.KeywordsCommunication SkillInterpersonal SkillImpression ManagementPast PerformanceUnstructured InterviewThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
ChemInform Abstract: First Synthesis of Totally Orthogonal Protected α‐(Trifluoromethyl)‐ and α‐(Difluoromethyl)arginines.

Field: Chemistry (Physical Sciences)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.