jimnoneill/paper-to-field-training huggingface dataset:
A Self-Guided Relaxation Module for Telepsychiatric Services: Development, Usefulness, and Feasibility

Field: Health Professions (Health Sciences)

Objective: A modified form of the standard autogenic relaxation exercise was developed as part of a telepsychiatry project, which aims to deliver mental healthcare to remote areas through the net, and through the agency of non-specialists. This study describes the development and evaluation of a brief and simpler form of a relaxation technique, the Self-Guided Relaxation (SGR). Method: SGR is a systematic technique to focus on muscle groups and feel the heaviness and relaxation through suggestions to induce relaxation in the body. The SGR was taught to 37 patients with different psychiatric disorders over two sessions a week apart. Measures of change used were scores on the Hamilton Anxiety Rating Scale (HAM-A) and a visual analog scale. Its usefulness and feasibility was examined over a follow-up period of one month. Additionally a group of non-specialists was trained in SGR supplemented by audiovisual aids and printed instructions. These therapists rated the ease in learning and administering SGR in patients. Results: There was a consistent reduction in the HAM-A scores over the follow-up period among patients. Improvements were also noted in positive experiences, adherence, depth of relaxation achieved, perceived benefit, and patient satisfaction. Majority of the patients, relatives, and therapists reported that they could administer or practice SGR after having learned the technique in a single session lasting about 30 minutes. The use of audio-video aids and manual was helpful in making the process of learning easy. Conclusions: Preliminary findings of usefulness, feasibility, and acceptance of the SGR were encouraging. These findings pave way for larger, randomized controlled study and for testing applicability of the SGR as a net-based psychological intervention.
LIVING WITH PROGRESSIVE CHILDHOOD ILLNESS

Field: Health Professions (Health Sciences)

This investigation is an exploratory study of parental management of progressive childhood neuromuscular disease. It focuses on parents for their significance as the primary managers of their children's diseases. The study, through its fieldwork component for the collection of data, utilizes participant observation. The researcher lived with each of six families for four days and nights to learn of the main concerns of parents with children who have Duchenne muscular dystrophy and Werdnig-Hoffmann disease, and the ways in which the parents manage these concerns. General patterns of positive parental management are defined and are followed by descriptions, in functional terms, of some of the strategies that parents employ to carry out these patterns.
S-07-4: VASCULAR SMOOTH MUSCLE CELL PROTEOME AND PHENOTYPIC SWITCHING IN HUMAN HYPERTENSION ARE NOX5-DEPENDENT

Field: Medicine (Health Sciences)

Objective: Reactive oxygen species (ROS) play a key role in the regulation of vascular smooth muscle cell (VSMC) phenotypic switching in hypertension. Nox5 is a major ROS-generating enzyme in vascular cells and is upregulated in hypertension. However, the effects of Nox5-derived ROS on VSMC proteome and phenotype in human hypertension are unknown. We aimed to characterize the global and oxidative proteomic profile and VSMC phenotype in human hypertension and the role of Nox5. Design and method: VSMC from resistance arteries from normotensive (NT) and hypertensive (HT) subjects were studied (n = 5). Proteins were labelled with isobaric tandem mass tags and identified by liquid chromatography tandem mass spectrometry. The oxidative proteome was assessed using stable isotope-labelled iodoacetamide to target cysteine thiols. Nox5 silencing was performed by siRNA. Protein expression was detected by western blotting. The inflammatory, pro-fibrotic and mitogenic phenotype of VSMCs was assessed by measuring pro-inflammatory cytokines (IL-6, IL-8), pro-collagen I in the culture media. Results: Proteomic analysis identified 207 proteins upregulated in HT subjects (fold change > 1.5, p < 0.05). Gene ontology enrichment analysis of upregulated proteins in HT showed most proteins belong to extracellular space and plasma membrane compartments and were involved in extracellular matrix organization (ECM), immune response and cell proliferation. ECM proteins COL1A1, COL9A1, COL10A1, FBN1, FBLN1 were increased in cells from HT, suggesting a switch to a fibroblast-like phenotype in hypertension. Expression of proteins related to interferon and IL-1β pathways (IFIT1, IFIT2, IFIT3, MX1, MX2, ABCA1, ABCA2, IL1RAP, CD36, ICAM1) were also increased in cells from HT subjects. The VSMC oxidative proteome analysis identified 130 significantly regulated cysteine-containing peptides, 88 showed increased oxidation in HT (fold change> 1.5, p < 0.05). Among the highly oxidized proteins in HT were ECM proteins, COL11A1, COL16A1, FBLN1 and FBLN2. VSMCs from HT subjects exhibit increased expression of the proliferation marker, PCNA (0.162 ± 0.3 vs NT:0.051 ± 0.04 relative fluorescence units, p < 0.05) and pro-collagen I (23.6 ± 2 vs NT:13.2 ± 0.3 ng/ml, p < 0.05). Production of pro-inflammatory cytokines IL-6 (501.8 ± 23.6 vs NT:121.7 ± 6.4 pg/mL) and IL-8 (373.6 ± 34.1 vs NT:262.5 ± 24.6 pg/mL, p < 0.05) were increased in HT. Nox5 silencing in VSMC from HT subjects reduced PCNA expression(43%), pro-collagen I release (8%), baseline and LPS-induced IL-6 (30% baseline, 43% LPS-induced) and IL-8 (21% baseline, 23% LPS-induced) release (p < 0.05). Conclusions: Our study provides new insights into the proteomic changes related to vascular phenotype in hypertension and demonstrated that Nox5 plays an important role in VSMC phenotypic switching associated with vascular injury and remodelling in hypertension.
DELAYED OVARIAN CYCLICITY DOES NOT REFLECT BLOOD METABOLITES IRREGULARITY IN POSTPARTUM HOLSTEIN COWS

Field: Veterinary (Health Sciences)

An experiment was conducted to investigate the effect of different types of ovarian cycles on reproductive indices and blood metabolites in 61 Holstein cows. Blood samples were taken from each cow between day 12 and day 50 postpartum (PP). Serum progesterone concentrations were measured to determine the onset of luteal function and different types of luteal dysfunctions in cows. Serum glucose, cholesterol and blood urea nitrogen concentrations were measured in the cows with normal and abnormal ovarian cyclicity. In this study, 29 (47.5%) cows showed normal ovarian cyclicity with first luteal activity detected before day 50 days PP, whereas 32 (52.5%) cows showed abnormal cyclicity. Of the 32 cows with abnormal patterns, 13 (21.3%) had prolonged luteal phase (PLP), 7 (11.5%) had short luteal phase (SLP) and 12 (19.7%) had delayed first ovulation (delayed ovulation).Progesterone concentration at different times was considerably varied from day to another day (P≤0.01), while the main effect of the group on the progesterone concentration was significant (P≤0.01). Cows that had normal cyclicity showed earlier luteal activity (P≤0.01) and shorter interval to first ovulation (P≤0.01) compared to cows with abnormal cyclicity. There were no significant differences in different blood metabolites between cows with normal or abnormal cyclicity. In conclusion, a high percentage (52.5%) of the postpartum cows had abnormal ovarian cycles. The abnormal ovarian cycles reduced the reproductive performance of dairy cows, including the onset of luteal activity and interval to first ovulation. Blood metabolites were not associated with postpartum abnormal cycles in cows.
Black Hole Formation and Fallback during the Supernova Explosion of a 40 M⊙ Star

Field: Physics and Astronomy (Physical Sciences)

Abstract Fallback in core-collapse supernovae is considered a major ingredient for explaining abundance anomalies in metal-poor stars and the natal kicks and spins of black holes (BHs). We present a first 3D simulation of BH formation and fallback in an “aborted” neutrino-driven explosion of a 40 solar mass zero-metallicity progenitor from collapse to shock breakout. We follow the phase up to BH formation using the relativistic CoCoNuT-FMT code. For the subsequent evolution to shock breakout we apply the moving-mesh code Arepo to core-collapse supernovae for the first time. Our simulation shows that despite early BH formation, neutrino-heated bubbles can survive for tens of seconds before being accreted, leaving them sufficient time to transfer part of their energy to sustain the shock wave as is propagates through the envelope. Although the initial net energy (∼2 Bethe) of the neutrino-heated ejecta barely equals the binding energy of the envelope, of hydrogen are still expelled with an energy of 0.23 Bethe. We find no significant mixing and only a modest BH kick and spin, but speculate that stronger effects could occur for slightly more energetic explosions or progenitors with less tightly bound envelopes.
In Situ Growth of Nitrogen-Doped Carbon-Coated γ‑Fe<sub>2</sub>O<sub>3</sub> Nanoparticles on Carbon Fabric for Electrochemical\nN<sub>2</sub> Fixation

Field: Chemical Engineering (Physical Sciences)

Although electrocatalytic N<sub>2</sub> fixation has been regarded\nas a promising alternative strategy to the current Haber–Bosch\ntechnique for ammonia synthesis, it still remains a great challenge\nto develop low-cost and high-efficiency electrocatalysts with high\ncatalytic activity and good selectivity. Here, we report the fabrication\nof a free-standing 3D hybrid electrode by in situ growth of N-doped\ncarbon-coated γ-Fe<sub>2</sub>O<sub>3</sub> nanoparticles supported\non carbon fabric (γ-Fe<sub>2</sub>O<sub>3</sub>-NC/CF), which\nmanifests a high Faradaic efficiency (FE) of 12.28% and a considerable\nammonia yield of 11.7 × 10<sup>–10</sup> mo1 s<sup>–1</sup> cm<sup>–2</sup>. Systematic characterization coupled with\ncomprehensive electrochemical studies imply that the cation vacancies\non the surface of γ-Fe<sub>2</sub>O<sub>3</sub>-NC/CF generated\nduring the electrochemical activation process majorly contribute to\nthe enhanced electrocatalytic activity for the nitrogen reduction\nreaction (NRR).
Quantitative Assessment of Right Ventricular Volumes and Ejection Fraction in Patients with Left Ventricular Systolic Dysfunction by Real Time Three‐Dimensional Echocardiography versus Cardiac Magnetic Resonance Imaging

Field: Medicine (Health Sciences)

Aims The aim of this study was to assess the accuracy and reproducibility of real time three‐dimensional echocardiographic ( RT 3 DE ) for the determination of right ventricular ( RV ) volumes and function in patients with left ventricular (LV) systolic dysfunction. Methods and Results Dedicated RT 3 DE was prospectively performed to assess RV volumes and EF in patients with LV systolic function identified on routine clinical cardiac magnetic resonance ( CMR ) imaging. RV end‐diastolic volume ( RV EDV ), RV end‐systolic volume ( RV ESV ), and RV EF were obtained using an offline analysis software (TomTec) by two observers blinded to CMR results. In this population of 27 patients with LV systolic dysfunction with a mean LV EF of 36 ± 12%, RV RT 3 DE dataset could be assessed in 27 of 30 patients (90%). High correlation was noted between RT 3 DE and CMR for RV EDV , ESV , and EF (r = 0.90, 0.89, and 0.77, respectively). RV EDV was lower by RT 3 DE as compared to CMR (129 ± 52 vs. 142 ± 53 mL, P = 0.005) while there was no significant difference in RV ESV and RV EF (71 ± 37 vs. 77 ± 45 mL, P = 0.146; 45 ± 11 vs. 48 ± 13%, P = 0.134, respectively). The intraclass correlation coefficient ranged from 0.94 to 0.94 between measurements and from 0.84 to 0.96 between observers. Conclusion Overall, RV volumes and EF assessed by RT 3 DE correlate well with CMR measurements in patients with LV dysfunction. RT 3 DE may be used as a more widely available and versatile alternative to CMR for the quantitative assessment of RV size and function in patients with LV dysfunction.
Aanzienlijke variatie in chirurgische behandeling van distale radiusfractuur

Field: Medicine (Health Sciences)

The optimum treatment of patients with distal radius fracture has not been entirely clarified resulting in possible major variations between hospitals in the number of patients undergoing surgical treatment. The objective of this study was to examine the variation in surgical treatment rates of patients with distal radius fractures across Dutch hospitals. Retrospective study. Aggregated data for all patients with a distal radius fracture were obtained for 2012 and 2013 on the basis of reimbursement codes. The surgical rate across hospitals was corrected for several variables using linear regression analysis. We analysed a total of 95,754 reimbursements. The operative rate ranged from 0% to 23%, with a mean of 9.6%. Hospital type, the percentage of females, the percentage of patients over 65, the mean age, average socioeconomic status, and the total number of patients treated explained only 2.6% of the observed differences in operative rate between hospitals in 2012 and 11.6% in 2013. Our results suggest that non-scientific factors, such as surgeon's age, background, and local culture, influence therapeutic decisions in patients with distal radius fractures
Optimal Design and Test of Main Magnet in Superconducting MRI

Field: Engineering (Physical Sciences)

The magnet system is an important part in magnetic resonance imaging (MRI) equipment, the performance of which directly affects the quality of the imaging. Improving the homogeneity of the magnetic field is an effective means to increase the signal-to-noise ratio (SNR). A high SNR ensures a good imaging. This paper mainly investigates the optimal design and homogenizing field analysis of main magnet for ferrite yoke flat-board type in superconducting MRI using the finite element method (FEM). In order to get a high homogeneous magnetic field, the pole piece is added on the magnetic pole. We use electric pure iron as the material of the pole piece which has low coercive force, high permeability, and high saturation flux density. In order to increase the calculation speed, three-dimensional analysis is replaced by two-dimensional analysis while keeping the precision adequate. Through the optimizing algorithm, we can obtain an ideal pole piece dimension of the magnet. The distribution of the magnetic field was simulated and tested experimentally. By comparing the numerical calculation results with the experimental results, we find that a superconducting magnet MRI having homogeneity in volume of interest less than 600 ppm can be designed by optimizing the dimension of the pole piece using the proposed method without shimming.
Geobotanical study of ruderal vegetation in the geoecological monitoring program of roadside ecosystems of the Cherkasy oblast

Field: Environmental Science (Physical Sciences)

The article is devoted to the dynamics of the spread of ruderal vegetation in phytocenoses of the roadside ecosystems of the Cherkasy oblast. Due to the high plowed area of the region, roadside field protection strips, in which, in fact, phytocenoses with the participation of ruderal plants are formed, are mostly very narrow (on average 10–15 m). Such ecotopic limitation creates extremely harsh ecological conditions in which only competitive (and sometimes aggressive) species survive. Unlike most works devoted to the formation of the phytodiversity in roadside phytocenoses, the authors follow the concept of infraecosystems presented in previous publications. The main distinguishing feature of this concept is the assumption of different states of formation of natural ecosystems on roadsides. In particular, by comparing the available phytodiversity in roadside phytocenoses with the «National Catalog of Biotopes», the degree of completeness of ecosystem formation at 19 study sites was assessed. Highways in the meridional (11 polygons) and latitudinal (8 polygons) directions were investigated within the Cherkasy oblast. Among the investigated phytocenoses at 19 polygons, only 4 phytocenoses, which spatially coincide with gas stations (Esco gas station, exit from the city of Uman, SOCAR gas station, near the village of Sharyn), or with relatively isolated settlements at the exits to the main route (Bilashki village, Rotmistrivka village). Invasive species (more than 10), which take an active part in the formation of the phytodiversity, were also found at all landfills. According to our estimates, the general trend of the formation of roadside ecosystems falls under the principle of Le Chatelier-Brown compensation, according to which the biosphere confirms its extraordinary ability to support life every time. After all, it can reduce, eliminate, and finally nullify any destructive (man-made) impact, filling existing and creating new ecological niches. Such an understanding of the geobotanical component in monitoring studies will help in the future to more correctly determine the role of man and the biosphere in the formation of anthropogenic landscapes, one of the more dynamic varieties of which are roadside landscapes. Keywords: ruderal plants, infraecosystem, phytocenosis, invasive species.
Identifying Colorectal Tumor For Single Cell RNA Sequence Using Rectified Linear Unit With Stochastic Gradient Descent

Field: Computer Science (Physical Sciences)

To detect cell clusters in whole human colorectal tumor cells, mechanisms based on single-cell RNA sequencing have been reported. To address such issues, a deep learning technique for single-cell analysis was recently developed, with promising results. Single- cell RNA sequence data contains detailed information about the transcriptome profile. Through gene expression, this information is presented in the form of patterns. The neural network is shown here to help understand these data representatives. Then we use the differential expression to identify distinct cell types and gene markers. Finally, the proposed identifying colorectal tumor for single-cell RNA sequencing that Rectified Linear Unit (ReLu) with Stochastic Gradient Descent(SGD) is compared to other recently developed models such as ReLu with Adam, ReLu with Limited-BFGS-B, TanH with Adam, TanH with SGD, TanH with Limited-BFGS-B, Sigmoid with Adam, Sigmoid with SGD, Sigmoid with Limited-BFGS-B, Linear with Adam, Linear with Limited-BFGS-B and Linear with SGD. At the moment, the results from identifying colorectal tumor for single-cell RNA sequencing that ReLu with SGD performs better than other recently developed models.
Energy-efficient packet transmission over a wireless link

Field: Computer Science (Physical Sciences)

The paper considers the problem of minimizing the energy used to transmit packets over a wireless link via lazy schedules that judiciously vary packet transmission times. The problem is motivated by the following observation. With many channel coding schemes, the energy required to transmit a packet can be significantly reduced by lowering transmission power and code rate and therefore transmitting the packet over a longer period of time. However, information is often time-critical or delay-sensitive and transmission times cannot be made arbitrarily long. We therefore consider packet transmission schedules that minimize energy subject to a deadline or a delay constraint. Specifically, we obtain an optimal offline schedule for a node operating under a deadline constraint. An inspection of the form of this schedule naturally leads us to an online schedule which is shown, through simulations, to perform closely to the optimal offline schedule. Taking the deadline to infinity, we provide an exact probabilistic analysis of our offline scheduling algorithm. The results of this analysis enable us to devise a lazy online algorithm that varies transmission times according to backlog. We show that this lazy schedule is significantly more energy-efficient compared to a deterministic (fixed transmission time) schedule that guarantees queue stability for the same range of arrival rates.
Photoelectric conversion and second-order optical nonlinearity of Langmuir–Blodgett films of a novel dipolar two-dimensional material

Field: Materials Science (Physical Sciences)

A dipolar two-dimensional multifunctional (D–π)3–A dye molecule, 2,4,6-tris(4-octadecyloxystyryl)pyrylium tetrafluoroborate (OP3) was synthesized. The dye molecule was successfully transferred onto an ITO electrode or quartz by LB techniques. The second-harmonic generation (SHG) and photoelectric conversion (PEC) properties of monolayers of this "umbrella-molecule" were studied under 10 mN m−1 and 30 mN m−1 surface pressure. The different tilt angles of the "umbrella-molecules" result in the difference in SHG and PEC properties. Both SHG and PEC properties of OP3 obtained under 30 mN m−1 are better than those obtained under 10 mN m−1.
KOMPOSISI UDANG HASIL TANGKAPAN JARING CIKER PADA NELAYAN TEGALKAMULYAN DI KABUPATEN CILACAP

Field: Agricultural and Biological Sciences (Life Sciences)

The purpose of this research was to investigate the catch composition and catch per unit effort of shrimp captured using ciker net of ﬁshermen in Tegalkamulyan Cilacap district. The sample was collected using ciker net between the ﬁrst week of February and April 2008. The samples were separated between shrimp and ﬁshes then measured total biomass weight. Individual shrimp was identiﬁ ed, measured their weight and total length. The daily shrimp catch data was grouped based on lunar circulation into new moon, ﬁrst quarter, full moon and third quarter. The t-test and anova was performed to the means catch between shrimp and ﬁsh, and shrimp and group of catch. The results showed that the catch during new moon was signiﬁcantly higher than full moon, but not signiﬁcantly different with the ﬁrst and third moon. The average catch per trip of ciker net composted of shrimp (9.27 kg) which was not signiﬁcantly different with ﬁsh weight (6.8 kg). The shrimp catch composed of ﬁ ve species, namely: Penaeus monodon, Penaeus merguiensis, Metapenaeus ensis, Penaeus longipes and Parapenaopsis sculptilis. The highest average catch of shrimp was P. merguiensis 5.76 kg (62.2%) then followed by M. ensis 2.03 kg (21.9%), while the rest was other shrimp. Based on individual length and weight, P. monodon, P. merguiensis and M. ensis were categorized into big size shrimps, while others were small size. The sex ratio of P. monodon and P. merguiensis was 1:1, while others were not equally to 1:1.
Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcumin.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Angiogenesis is a crucial step in the growth and metastasis of cancers. Curcumin inhibits tumor initiation and growth. We analyzed the effect of curcumin on endothelial cell migration, attachment, and tube formation on Matrigel. Curcumin had no effect on endothelial cell migration or attachment to either plastic or Matrigel. Curcumin treatment resulted in a dose-dependent inhibition of tube formation when the cells were treated before plating or at the time of plating on Matrigel. Curcumin treatment also caused the preformed tubes to break down. Curcumin inhibited angiogenesis in a s.c. Matrigel plug model in mice. The role of metalloproteinases has been shown to be important in angiogenesis; therefore, zymography was performed to determine whether curcumin affected protease activity. Zymographs of curcumin-treated culture supernatants showed a decrease in the gelatinolytic activities of secreted 53- and 72-kDa metalloproteinases. Western and Northern analysis showed a dose-dependent decrease in the protein expression and transcript of 72 kDa, indicating that curcumin may be exerting its inhibitory effect at both the transcriptional and posttranscriptional level. These findings suggest that curcumin acts as an angiogenesis inhibitor by modulating protease activity during endothelial morphogenesis. Curcumin could be developed as an antiangiogenic drug.