jimnoneill/paper-to-field-training huggingface dataset:
Effect of Mesenchymal Stem Cells and Chicken Embryo Extract on Flap Viability and Mast Cells in Rat Skin Flaps

Field: Medicine (Health Sciences)

Study Objective: We investigated the effect of bone marrow mesenchymal stem cells (BMMSCs) and chicken embryo extract (CEE), alone and in combination, on tissue viability of skin flaps, and mast cells (MCs), in an experimental random skin flap (RSF) rat model. Materials and Methods: A 30 mm × 80 mm RSF was made on the dorsum of each of the forty rats, which were then divided into four groups. One group did not receive any treatment and served as the control, the second group received BMMSCs, the third group received CEE + BMMSCs, and the fourth group received CEE. For BMMSC treatment, 6 × 109 BMMSCs were injected into twelve separate injection sites of each flap. Seven days after RSF surgery, the remaining viable part of each flap was measured and examined to determine the number of blood vessels, MCs, and degranulated MCs. Results: The CEE, CEE + BMMSC, and BMMSC groups displayed significantly higher levels of flap viability (ANOVA test: p = 0.000; LSD test for all groups: p = 0.000), and a greater number of vessels (ANOVA test: p = 0.000; LSD test: p = 0.000, 0.002, and 0.012, respectively), compared with the control group. The flap viability was poorer in the BMMSC group than in the CEE and CEE + BMMSC groups. The BMMSC group also had a greater number of degranulated and total MCs, compared with the CEE and CEE + BMMSC groups. Conclusions: We observed biostimulatory effects of BMMSCs, CEE, and CEE + BMMSCs on flap viability and vessel numbers, compared to the control group. MCs produced in response to BMMSC treatment have an inhibitory effect on the RSFs survival in an ischemic tissue model.
Oral Techniques and Commitment in the Poetry of Okot P'bitek and Kofi Anyidoho: Their Contributions to Modern African Poetry

Field: Arts and Humanities (Social Sciences)

Modern African poetry has come to stay, and has made outstanding contributions to world literature through its use of traditional African oral poetic techniques. In this direction, one of the earliest innovators in modern African poetry has been the Ugandan, the late Okot p’Bitek, whose poetry has had a profound effect on the African poetic canon through the decades. Another poet who has also affected the African poetic scene with his craft in the 80’s has been the Ghanaian, Kofi Anyidoho. This paper attempts to study these two poets, their innovation in the use of language and oral poetic techniques, and their contributions to African poetry in terms of themes and techniques of presentation. On the whole, for both poets, the skillful adaptation and use of indigenous African Oral poetic techniques has helped to improve their craft, their effectiveness as masses-oriented poets, as well as their vision.
Biomechanics of Cervical Disk Replacement

Field: Engineering (Physical Sciences)

Cervical disk arthroplasty has been employed with increased frequency over the past 2 decades as a motion-preserving alternative to anterior cervical discectomy and fusion in select patients with myelopathy or radiculopathy secondary to degenerative disk disease. As indications continue to expand, an understanding of cervical kinematics and materials science is helpful for optimal implant selection. Cervical disk arthroplasty implants can be classified according to the mode of articulation and df , articulation material, and endplate construction. The incorporation of translational and rotational df allows the implant to emulate the dynamic and coupled centers of movement in the cervical spine. Durable and low-friction interfaces at the articulation sustain optimal performance and minimize particulate-induced tissue reactions. Endplate materials must facilitate osseous integration to ensure implant stability after primary fixation. These cardinal considerations underlie the design of the 9 implants currently approved by the FDA and serve as the foundation for further biomimetic research and development.
NEW POSSIBILITIES OF STATIN THERAPY IN ARTERIAL HYPERTENSION

Field: Medicine (Health Sciences)

Background. Effects of statins on cardiovascular end points are well-known. To study the impact of statins on structural and functional heart remodeling in patients with arterial hypertension (HT) seemsto be topical.Aim. To study the effect of statins on cardiac remodeling in patients with HT.Materials and methods. 120 patients with HT of 1 degree were included into the study: 56 men, 64 women, aged 52.4±10.23. Patients were randomized into 4 treatment groups: Group A1 (angiotensin converting enzyme (ACE) inhibitors + diet), group A2 (ACE inhibitor + fluvastatin), group B1 (angiotensin II receptor antagonist (ARA II) + diet), group B2 (ARAII + fluvastatin). Transthoracic echocardiography with calculation of standard left ventricle (LV) remodeling indices was performed.Results. The most important prognostic markers of LV remodeling were revealed. They were a basis for definition of 3 types of early LV remodeling: type 1 — compensated, type 2 — adaptive, 3 type — maladaptive. After 6 months of treatment a number of patients in group A1 with type 2 and type 3 of LV remodeling reduced less (2%, p=0.02 and 4%, p=0.04, respectively) than this in group A2 (14%, p=0.04) and 4%, p=0.04, respectively). A number of patients with type 1 (compensated) of LV remodeling increased by 18% (p<0.001) in group A2, and by 6%, (p=0.03) in group A1. After the treatment a number of patients with type 3 and type 2 of LV remodeling decreased (p<0.001 and p=0.04, respectively) in groups B1 and B2 while a number of patients with type 1 of LV remodeling increased (p<0,001). A number of patients with type 1 of LV remodeling increased and this with type 3 of LV remodeling decreased in group B2 more prominently in comparison with group A2 (p=0.03; p=0.01, respectively).Conclusion. Statins in patients with HT have cardioprotective effect that does not depend on basic antihypertensive therapy and total cholesterol level. In these patients combination of statins with ARA II has better cardioprotective effect than this with ACE inhibitors.
Philo of Alexandria on the Twelve Olympian Gods

Field: Arts and Humanities (Social Sciences)

© 2019 Johns Hopkins University Press. All rights reserved. The importance of pagan philosophy and literature for Philo’s thinking has long been acknowledged. What is less studied, however, is his attitude towards the individual gods of the Greek pantheon, and this is the topic of the present article. After a brief discussion of Philo’s critical stance towards Greek polytheism in general, a first survey of relevant material is provided that already allows for a few provisional conclusions. This is followed by a more detailed analysis of the argumentative strategies which Philo uses while dealing with the Olympian gods. This analysis shows that Philo adopted a quite sophisticated and strategic position towards the Olympians: while there can be little doubt about his negative view, he as a rule avoids straightforward criticism of particular gods and prefers to either ignore them or cleverly reorient them towards his own Scriptural perspective.
UPAYA PENINGKATAN PERAN SUPERVISI KEPALA SEKOLAH TERHADAP PELAKSANAAN TUGAS POKOK GURU DI SMAN 10 TEBO

Field: Social Sciences (Social Sciences)

This study aims to reveal the supervisory role of the principal in carrying out the main tasks of the teacher in planning, implementing and evaluating the learning process. This study uses an Action Research Approach. The results of this study indicate that the results of supervision carried out by the principal can improve the implementation of the teacher's main tasks. This also proves that the supervision of the principal and individual meetings with each teacher to reflect on the learning process have a very important role in improving the implementation of the teacher's main duties. The implication of this research is that if the supervisory role of the school principal is always carried out, then the learning process in the classroom will provide good feedback between teachers and students. ABSTRAKPenelitian ini bertujuan untuk mengungkapkan peranan supervisi kepala sekolah terhadap pelaksanaan tugas pokok guru dalam merencanakan, melaksanakan dan mengevaluasi proses pembelajaran. Penelitian ini menggunakan Pendekatan Action Research. Hasil penelitian ini menunjukan hasil supervisi yang dilaksanakan kepala sekolah dapat meningkatkan pelaksanaan tugas pokok guru. Hal ini juga membuktikan bahwa supervisi kepala sekolah dan pertemuan individual dengan masing-masing guru untuk merefleksi proses pembelajaran punya peranan yang sangat penting dalam meningkatkan pelaksanaan tugas pokok guru. Implikasi dari penelitian ini jika peran supervisi kepala sekolah selalu dilaksanakan, maka proses pembelajaran di kelas akan memberi feedback yang baik antara guru dan siswa.
The Lock of Berenice

Field: Arts and Humanities (Social Sciences)

Abstract The third chapter discusses a moment of profound crisis in Seleucid history: the dynastic strife between the two wives of Antiochus II resulting in the Third Syrian War. It argues that Callimachus’ Lock of Berenice can be read as a poetic commentary on a key moment of crisis for the Seleucid Empire, in that it subtly contrasts the failure of a Seleucid dynastic marriage with the success of the Ptolemaic royal couple, which is placed in an unbroken tradition that reaches back via Arsinoe II and Ptolemy II to Berenice I and Ptolemy I. In the second part of the chapter, it is argued that Callimachus exploits Ptolemaic royal propaganda to cast the Seleucids as the heirs of the Persians and other Eastern empires, rather than a Greek kingdom. The final part of the chapter draws out the broader poetic implications of anti-Seleucid polemic by looking at the Aetia and the Hymn to Apollo.
Information Processing vs Visual Attention during Incidental Learning

Field: Psychology (Social Sciences)

The relationship between attention and incidental learning during discrimination training was studied in 30 children, aged 10 to 11. A polymetric eye-movement recorder measured direct visual attention. Consistent with previous findings, recall of incidental stimuli was greatest during the initial and terminal stages of intentional learning. Contrary to previous explanations, however, visual attention to incidental stimuli was not related to training. While individual differences in attention to incidental stimuli were predictive of recall, attention to incidental stimuli was not related to level of training. Results suggested that changes in higher order information processing rather than direct visual attention were responsible for the curvilinear learning of incidental stimuli during intentional training.
Pharmacological Inhibition of Endotoxin Responses Is Achieved by Targeting the TLR4 Coreceptor, MD-2

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract The detection of Gram-negative LPS depends upon the proper function of the TLR4-MD-2 receptor complex in immune cells. TLR4 is the signal transduction component of the LPS receptor, whereas MD-2 is the endotoxin-binding unit. MD-2 appears to activate TLR4 when bound to TLR4 and ligated by LPS. Only the monomeric form of MD-2 was found to bind LPS and only monomeric MD-2 interacts with TLR4. Monomeric MD-2 binds TLR4 with an apparent Kd of 12 nM; this binding avidity was unaltered in the presence of endotoxin. E5564, an LPS antagonist, appears to inhibit cellular activation by competitively preventing the binding of LPS to MD-2. Depletion of endogenous soluble MD-2 from human serum, with an immobilized TLR4 fusion protein, abrogated TLR4-mediated LPS responses. By determining the concentration of added-back MD-2 that restored normal LPS responsiveness, the concentration of MD-2 was estimated to be ∼50 nM. Similarly, purified TLR4-Fc fusion protein, when added to the supernatants of TLR4-expressing cells in culture, inhibited the interaction of MD-2 with TLR4, thus preventing LPS stimulation. The ability to inhibit the effects of LPS as a result of the binding of TLR4-Fc or E5564 to MD-2 highlights MD-2 as the logical target for drug therapies designed to pharmacologically intervene against endotoxin-induced disease.
Reasoning about the function and timing of integrated circuits with interval temporal logic

Field: Computer Science (Physical Sciences)

Important aspects of behavior at the transistor level are discussed, including timing and capacitance. In the approach described here, the structures of circuits and their functional behavior are described with interval temporal logic (ITL). These specifications are expressed in Prolog, and the logical manipulations of the proof process are achieved with the Prolog system. To demonstrate the flexibility of this approach, the behavior of several CMOS circuits designed with different design styles is described. These examples include a dynamic latch and a 1-b adder, both of which use a two-phase clocking scheme and exploit charge storage. The 1-b adder is a sophisticated full adder implemented with a dynamic CMOS design style. Timing as well as functional aspects of behavior are derived, and constraints on the way a circuit interacts with its environment are reasoned about formally.< >
Dual-Conductive and Stiffness-Morphing Microneedle Patch Enables Continuous In Planta Monitoring of Electrophysiological Signal and Ion Fluctuation

Field: Engineering (Physical Sciences)

The use of conductive microneedles presents a promising solution for achieving high-fidelity electrophysiological recordings with minimal impact on the interfaced tissue. However, a conventional metal-based microneedle suffers from high electrochemical impedance and mechanical mismatch. In this paper, we report a dual-conductive (i.e., both ionic and electronic conductive) and stiffness-morphing microneedle patch (DSMNP) for high-fidelity electrophysiological recordings with reduced tissue damage. The polymeric network of the DSMNP facilitates electrolyte absorption and therefore allows the transition of stiffness from 6.82 to 0.5139 N m-1. Furthermore, the nanoporous conductive polymer increases the specific electrochemical surface area after tissue penetration, resulting in an ultralow specific impedance of 893.13 Ω mm2 at 100 Hz. DSMNPs detect variation potential and action potential in real time and cation fluctuations in plants in response to environmental stimuli. After swelling, DSMNPs mechanically "lock" into biological tissues and prevent motion artifact by providing a stable interface. These results demonstrate the potential of DSMNPs for various applications in the field of plant physiology research and smart agriculture.
Introducing new Link Prediction Measures and an Evaluation Metric

Field: Computer Science (Physical Sciences)

Abstract

Link prediction plays a critical role in network analysis as it tackles the task of predicting missing or future connections within a given network. A wide array of link prediction measures has been proposed to estimate the likelihood of link existence between nodes, aiming to uncover hidden relationships and anticipate the formation of new connections. This task holds particular significance in various domains, including social networks, biological networks, transportation networks, and recommender systems. Nonetheless, evaluating the effectiveness of these measures poses challenges, encompassing both the measures themselves and the employed evaluation metrics. This article offers a comprehensive overview of the existing link prediction measures, shedding light on their limitations and addressing the associated challenges in evaluating their efficacy. Moreover, we propose enhancements to overcome these challenges, entailing modifications to existing measures and the introduction of novel evaluation metrics. By tackling these issues head-on, our objective is to enhance the accuracy and reliability of link prediction in network analysis.
Abstract SY13-03: Novel targeted therapies in myelodysplastic syndrome

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Ubiquitin ligases target specific proteins for degradation, and pharmacologic modulation of ubiquitin ligase activity has the potential for therapeutic efficacy in cancer by altering the abundance of proteins that are required for tumor cell survival. Thalidomide and its derivatives, lenalidomide and pomalidomide, represent the first class of drugs that act by binding and changing the activity of a specific ubiquitin ligase. These compounds bind the CRL4-CRBN ubiquitin ligase, inducing the ubiquitination and consequent degradation of specific protreins. Lenalidomide is a highly effective drug for the treatment of myelodysplastic syndrome (MDS) with del(5q), multiple myeloma, and some additional B cell lymphomas. In multiple myeloma cells, lenalidomide increases the binding of two substrates, IKZF1 and IKZF3, to the CRBN substrate adapter; increases the ubiquitination of these substrates; and causes the targeted degradation of IKZF1 and IKZF3, transcription factors that are essential for the differentiation and survival of plasma cells including multiple myeloma cells. In del(5q) MDS, lenalidomide targets CSNK1A1 for destruction. Haploinsufficiency for CSNK1A1, a gene located within the common deleted region on chromosome 5q, results in selective targeting of the del(5q) clone. Recent studies indicate that lenalidomide, pomalidomide, and thalidomide modulate the CRl4-CRBN ubiquitin ligase in distinct ways, raising the possibility that new molecules may induce degradation of other proteins, creating new therapeutic opportunities. Citation Format: Benjamin Ebert. Novel targeted therapies in myelodysplastic syndrome. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr SY13-03. doi:10.1158/1538-7445.AM2015-SY13-03
The evaluation of the reporting quality of observational studies in Master of Public Health’s dissertations in China

Field: Health Professions (Health Sciences)

Abstract Backgrounds Master of public health (MPH) plays an important role in Chinese medical education, and the dissertations is an important part of MPH education. In MPH dissertations, most are observational studies. Compared with randomized controlled trial (RCT), observational studies are more prone to information bias. So, the reporting of the observational studies should be transparent and standard. But, no research on evaluating the reporting quality of the MPH dissertation has been found. Methods A systematic literature search was performed in the Wanfang database from January 1, 2014 to May 31, 2019. The Strengthening the Reporting of Observation Studies in Epidemiology (STROBE) statement was adopted to evaluate the reporting quality of the selected studies. Articles that met the following criteria were selected: (1) observational studies, including cross-sectional studies, case-control studies, and cohort studies; (2) original articles; (3) studies on humans, including both adults and children. Results The Median of compliance to individual STROBE items was 74.79%. The mean (standard deviation) of STROBE score was 14.29 (1.84). Five items/sub-items were 100% reported (“reported” and “partly reported” were combined): background, objectives, study design, report numbers of individuals at each stage, and key result. Fifteen items/sub-items were reported by 75% or more. Reporting of methods and results was often omitted: missing data (6.67%), sensitivity analyses (3.63%), flow diagram (15.15%), and absolute risk (0%). Logistic regression analysis indicated that cohort studies (OR=3.41, 95% CI=1.27-9.16), funding support (OR=4.37, 95% CI=1.27-9.16) and more published papers during postgraduate period (OR=3.46, 95% CI=1.40-8.60) were related to high reporting quality. Conclusion In short, the reporting quality of observational studies in MPH’s dissertations in China is suboptimal. However, it’s necessary to improve the reporting of method and results sections. We recommend that authors should be stricter to adhere STROBE statement when conducting observational studies.
Postoperative pain perception and associated risk factors in children after continuous rotation versus reciprocating kinematics: A randomised prospective clinical trial

Field: Dentistry (Health Sciences)

Abstract To compare the postoperative pain of continuous rotation and reciprocating movements after pulpectomy of non‐vital primary molars and determine associated risk factors. 146 children aged 4–8 years with one primary molar indicated for pulpectomy were randomly assigned to two equal groups: those instrumented with continuous rotation motion (Hyflex EDM Coltene/Whaledent) and reciprocating motion (Reciproc R25 (VDW)). A 4‐point pain scale was used to assess postoperative pain frequencies, which were compared at different intervals using the Chi‐square test. Postoperative pain risk factors were determined using logistic regression analysis. There was no statistically significant difference between the follow‐ups. Gender, pulp status, and radiographic radiolucency increased the risk of postoperative pain incidence. Postoperative pain likelihood in children with chronic apical periodontitis was 8.72 times that of children with necrotic pulps. Postoperative pain after instrumentation with both kinematics was comparable. Postoperative pain incidence is increased by preoperative pulp condition, radiographic radiolucency, and gender.
Accuracy of basic school teachers knowledge in the english terms materials of game better education

Field: Social Sciences (Social Sciences)

Students of the Elementary School have core competencies and basic competencies that must be achieved according to the 2013 curriculum contained in Minister of Education and Culture Regulation number 24 of 2016 concerning Core Competencies and Basic Competencies of Learning in the 2013 Curriculum on Basic Education and Secondary Education. In PERMENDIKBUD number 24 (2018) it is stated that curriculum objectives include four competencies, namely (1) spiritual attitude competency, (2) social attitude, (3) knowledge, and (4) skills. The competency is achieved through extracurricular, curricular and / or extracurricular learning processes. The importance of the correct use of terms in learning materials in schools is one of the important things where in the academic world the use of standard language is a must. In sports and health physical education material which on several occasions uses the term in English, remembering that sports culture originates from a global culture that uses the English term needs to be mastered appropriately by physical and physical education teachers. The questionnaire is used as a data collection tool that uses descriptive quantitative analysis and research data will be obtained from a questionnaire filled out by elementary school PJOK teacher participants in Bangkalan who attended the basic motion material socialization event carried out by the STKIP PGRI Bangkalan sports education study program. Data analysis techniques used by researchers in looking at the percentage of respondents from the questionnaire distributed. Based on the results of the research and discussion above it can be concluded that the understanding of the knowledge of the accuracy of the use of English terminology in the material of large ball games physical and sport education and the results of the analysis have shown that the accuracy of elementary school teachers in using the terminology in English to teach sports the body in elementary school the results are quite good.