jimnoneill/paper-to-field-training huggingface dataset:
Real‐Time PCR of cytomegalovirus and Epstein–Barr virus in adult Egyptian patients with systemic lupus erythematosus

Field: Medicine (Health Sciences)

Abstract Objective Infections may act as environmental triggers for induction of systemic lupus erythematosus ( SLE ). We sought to explore the relative frequencies of Epstein–Barr virus ( EBV ) and human cytomegalovirus ( CMV ) in adult E gyptian patients with SLE and their correlation with disease activity and damage. Methods Thirty‐three consecutive adult patients satisfying the 1997 American College of Rheumatology ( ACR ) Classification Criteria for SLE and 30 healthy controls were included in this case–control study. All patients were subjected to complete clinical and laboratory evaluation to determine the Systemic Lupus Erythematosus Disease Activity Index ( SLEDAI ) and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index ( SLICC / ACR ). Sera from both groups were analyzed for immunoglobulin M (IgM) and IgG antibodies against CMV and EBV . Qualitative real time polymerase chain reaction ( PCR ) for both viruses was performed for all SLE patients. Results Almost all SLE patients 32/33 (96.9%) were positive for IgG anti‐ CMV antibodies versus 20/30 in the control group (66.6%) ( P = 0.002). All SLE patients were positive for IgG anti‐ EBV antibodies compared to 25 in the control group (100% vs . 83.3%, P = 0.02). CMV and EBV DNA were detected by PCR in 30.3% and 51.5% of SLE patients, respectively. A statistically significant lower SLEDAI was found in PCR positive patients for EBV compared to negative patients (9.6 ± 5.2 vs . 13.1 ± 3.1, respectively P = 0.041). Conclusions Adult E gyptian patients with SLE had higher frequencies of anti‐ CMV and EBV IgG compared to healthy controls. Furthermore, our single point assessment of SLEDAI suggested that exposure to EBV infection might be associated with a lower disease activity.
The Relationship between the Readability of Pupils' Compositions and their Measured Intelligence

Field: Psychology (Social Sciences)

Success in school subjects has been shown to be highly related to intelligence. The ability to solve arithmetical problems, to under stand written passages, to perceive relationships and common prin ciples, and to organize new material are all considered aspects of intellectual ability. The high correlation between vocabulary scores and mental age has even led to a suggestion that vocabulary tests be used as abbreviated measures of intelligence. Since the writing of compositions involves the ability to organize thoughts through the medium of vocabulary, it is to be expected that the quality of a per son's written expression would reflect his intellectual ability. Such expectations have been expressed by H. B. Reed who says, .... we should judge intelligence to be the most important single factor of ability in English composition. This is especially true in so far a s the quality of composition depends upon clearness and coherence. (5) Composition scales of a generation ago indicate that the relation ship between scores on compositions and intelligence is high. Studies using composition scales and teachers' grades have indicated that the level of written compositions increases with age and with school grade. In addition, it has been shown that within each school grade there is a large difference between the poorest and best pupil. Besides the more academic interest in knowing the relationship between writing ability and intelligence, there is a practical applica tion of such knowledge. It is sometimes desirable to estimate the ed ucational level or intelligence of an individual when the only available evidence is a sample of written composition. Wyant, in an analysis of letters written to senators, desired an estimate of the educational level of the respondents. For most of the respondents the only evi dence was the letter written to the senator. Max Kleinbaum rated 467
No Limits: Using Art to Inspire and Encourage Minorities to Pursue Careers in STEAM (STEM + Art)

Field: Arts and Humanities (Social Sciences)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTNo Limits: Using Art to Inspire and Encourage Minorities to Pursue Careers in STEAM (STEM + Art)Jayde Frederick*Jayde Frederick*Email: [email protected]More by Jayde Frederickhttps://orcid.org/0000-0001-9012-9462Cite this: ACS Bio Med Chem Au 2022, 2, 3, 171–172Publication Date (Web):June 15, 2022Publication History Published online15 June 2022Published inissue 15 June 2022https://doi.org/10.1021/acsbiomedchemau.2c00028Copyright © Published 2022 by American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceCC: Creative CommonsBY: Credit must be given to the creatorNC: Only noncommercial uses of the work are permittedND: No derivatives or adaptations of the work are permittedArticle Views139Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-AlertsSUBJECTS:Chemical engineering and industrial chemistry,Color,Elements,Neurophysiology,Water Get e-Alerts
Immunological manipulation of ovulation rate for twinning in cattle

Field: Veterinary (Health Sciences)

Unlike in sheep, in which immunization against androstenedione causes mild and reasonably controlled increased ovulation rate, in similar studies cattle showed highly variable responses ranging from increased ovulation rate and fertility through to anovulation/anoestrus or superovulation. As a consequence, interest in manipulation of ovulation rate through this approach has declined and is now focused on immunological manipulation of endogenous inhibin following successful studies in sheep. Studies have concentrated on developing a prototype inhibin-based vaccine to be used for twinning in the Australian beef industry. The prototype vaccine (with recombinant ovine inhibin-α.3 fusion protein and Montanide:Marcol adjuvant) has proved to be very potent and control of the degree of ovarian stimulation has not been possible. The proportion of cattle with increased ovulation rate after inhibin immunization is affected by timing of booster vaccination within the ovarian cycle, time after vaccination, vaccine formulation and possibly genotype. Physiological studies show that cattle responding to the inhibin vaccine have increased plasma inhibin binding of native bovine inhibin, high plasma FSH concentrations, greater numbers of large (≥ 8 mm) follicles and fewer small (< 5 mm) follicles during the preovulatory wave of follicular development compared with control or non-responding animals. Significant correlations among the response parameters (i.e. inhibin binding, plasma FSH concentrations, number of large follicles and ovulation rate) have been demonstrated. The results indicate that greater understanding of the various processes of folliculogenesis will be necessary to achieve a controlled increase in ovulation rate in cattle.
Impacts of a Prerequisite Online Laboratory Course

Field: Social Sciences (Social Sciences)

AbstractIn response to remote learning needs during the COVID-19 pandemic, introductory lecture and laboratory courses typically delivered fully in person were offered in a completely virtual format for the first time. Introductory laboratory courses are pivotal foundations for future discipline-specific learning and serve as prerequisites for a myriad of upper-level courses. To understand the impact of taking a prerequisite laboratory course online, we launched a study within our introductory chemistry curriculum. Two student groups in a fully in-person General Chemistry 2 laboratory course were studied in spring 2021—those who completed the prerequisite lab course online (N = 258) and those who fulfilled the prerequisite via an exam or dual-enrollment programs (N = 85). Using paired pre- and postsurveys, we examined student perceptions of their affective and cognitive learning and found the mode of prerequisite course did not affect student perceptions of cognitive learning but did influence affective expectations and perceived experiences. Herein, we discuss the divergences between the two student groups, the role the prerequisite online lab course played in student downstream learning, and recommendations for science lab instructors as institutions shift back to in-person environments. Additional informationNotes on contributorsElizabeth V. JonesElizabeth V. Jones (elizabeth_jones@hms.harvard.edu) is formerly a graduate student in the School of Chemistry and Biochemistry at the Georgia Institute of Technology in Atlanta, Georgia, and currently a postdoctoral research fellow in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School in Boston, Massachusetts.Michael EvansMichael Evans (michael.evans@ chemistry.gatech.edu) members of the teaching faculty in the School of Chemistry and Biochemistry at the Georgia Institute of Technology.Carrie SheplerCarrie Shepler (carrie.shepler@cos.gatech.edu) members of the teaching faculty in the School of Chemistry and Biochemistry at the Georgia Institute of Technology.
Maritime Geopolitical Strategy For Strengthening The Security of North Natuna Marine Waters Against

Field: Social Sciences (Social Sciences)

The North Natuna Sea is rich in marine resources, especially fish, and is part of Indonesia's Exclusive Economic Zone (EEZ). Illegal, unreported, and unregulated fishing (IUU fishing) in the North Natuna Sea region has become a crucial issue affecting Indonesia's maritime sovereignty and security. This article examines maritime geopolitical strategies that can be implemented to reduce fish theft in the region. The method used in this research is a qualitative method with a literature study to explore maritime geopolitical strategies to strengthen the security of the North Natuna Sea waters against IUU fishing. The proposed approach includes enhancing maritime defense capabilities, regional cooperation, and maritime diplomacy. In addition, monitoring and law enforcement are also the main focus.
High Ripple-Density Resolution for Discriminating Between Rippled and Nonrippled Signals: Effect of Temporal Processing or Combination Products?

Field: Neuroscience (Life Sciences)

The goal of the study was to investigate the role of combination products in the higher ripple-density resolution estimates obtained by discrimination between a spectrally rippled and a nonrippled noise signal than that obtained by discrimination between two rippled signals. To attain this goal, a noise band was used to mask the frequency band of expected low-frequency combination products. A three-alternative forced-choice procedure with adaptive ripple-density variation was used. The mean background (unmasked) ripple-density resolution was 9.8 ripples/oct for rippled reference signals and 21.8 ripples/oct for nonrippled reference signals. Low-frequency maskers reduced the ripple-density resolution. For masker levels from −10 to 10 dB re. signal, the ripple-density resolution for nonrippled reference signals was approximately twice as high as that for rippled reference signals. At a masker level as high as 20 dB re. signal, the ripple-density resolution decreased in both discrimination tasks. This result leads to the conclusion that low-frequency combination products are not responsible for the task-dependent difference in ripple-density resolution estimates.
Wyzwania oraz sposoby wsparcia chińskich studentów przygotowujących prace licencjackie

Field: Social Sciences (Social Sciences)

The article is concerned with the individualisation of teaching, using the example of tutorials accompanying the bachelor’s seminar in the undergraduate double degree programme: Polish studies: language, culture, society. It presents case studies which serve to illustrate the challenges and difficulties faced by Chinese students who worked on their bachelor’s theses. The article also describes the approach adopted by the teachers and the assistance they provided for the tutees, which allowed them to find satisfactory solutions together, respecting the cultural and educational background of the students as well as teaching standards and requirements for candidates for a bachelor’s degree at the Faculty of Polish Studies of the Jagiellonian University. The authors also comment on the preparation for the thesis defence and methods of remedying problems caused by pandemic restrictions.
Acute Osteomyelitis and Septic Arthritis

Field: Medicine (Health Sciences)

Although it is true that the outlook in acute osteo- myelitis and septic arthritis has been almost miraculously changed by the use of penicillin, successful treat- ment still requires early diagnosis, first-class medical and nursing care under continuous supervision, and adequate local and general supportive measures.In this article the discussion is limited to blood-borne pyo- genic infections, and in particular to the bone and joint disease of children usually due to infection by Staphylococcus aureus.
ICT education and access in public libraries: Library Development Program

Field: Social Sciences (Social Sciences)

During last years a rapid growth in access to information and communication technologies could be observed in Poland as well as in other European countries. At the same time many investigations show that access to the new technologies, knowledge about available services and IT skills are still not developed well enough. It&apos;s noticeable especially in poor and rural areas. Local public libraries in such areas are usually the only places providing ICT support for communities. The Information Society Development Foundation (ISDF) created by Polish-American Freedom Foundation (partnered with Bill and Melinda Gates Foundation) ordered a set of reports to better understand the level of ICT access and services provided to the people by local public libraries. Majority of libraries are equipped with computers and are connected to the Internet, although the quality of hardware and the Internet bandwidth are not always meeting current standards. The Library Development Program (LDP) is set for the period of 2009-2013 and aims to change the image of making them centers of cultural and social activities. However, to reshape a library into modern information center, attractive for local communities, librarians and libraries have to change. Library will meet user’s needs only when librarians will be fluent in the world of digital information, thanks both to their improved skills and access to better information
Trochanteric spurs and surface irregularities on plain radiography are not predictive of greater trochanteric pain syndrome

Field: Medicine (Health Sciences)

Purpose: Surface irregularities of the greater trochanter have been described as a potential radiographic sign of greater trochanteric pain syndrome (GTPS). We report a diagnostic accuracy study to evaluate the clinical usefulness of trochanteric surface irregularities on plain radiographs in the diagnosis of GTPS. Methods: We retrospectively identified the anteroposterior pelvic radiographs of a consecutive group of 38 patients (representing a 27.5% series prevalence) diagnosed with GTPS (mean age 69.5 years ± 16.1 [standard deviation], 27 females, 11 males) based on clinical symptoms and a positive response to a local anaesthetic and steroid injection. A control group consisted of 100 patients (mean age 73 years ± 17.1 [standard deviation], 67 females, 33 males) with either hip osteoarthritis listed for hip arthroplasty ( n = 50), or with an intracapsular neck of femur fracture ( n = 50) both presenting between January and July 2017. Radiographs were cropped to blind observers to the presence of hip osteoarthritis or intracapsular fracture but included the trochanteric region. The radiograph sequence was randomised and separately presented to 3 orthopaedic surgeons to evaluate the presence of trochanteric surface irregularities. Results: The inter-observer correlation coefficient agreement was acceptable at 0.75 (95% CI, 0.60–0.84). Trochanteric surface irregularities including frank spurs protruding ⩾2 mm were associated with a 24.7% positive predictive value, 64.0% sensitivity, 25.7% specificity, 74.3% false-positive rate, 36.0% false-negative rate, and a 65.3% negative predictive value for clinical GTPS. Conclusion: Surface irregularities of the greater trochanter are not reliable radiographic indicators for the diagnosis of greater trochanteric pain syndrome.
Abstract 3490: Identification and characterization of novel galectin-9 splice variants in endothelial cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Evidence is accumulating that endothelial galectins play an important role in tumor angiogenesis. Recently, we reported altered galectin-9 expression during endothelial cell activation. Here, we further assessed the expression and function of galectin-9 in endothelial cells. Using cDNA flanking PCR and subsequent cloning we identified 5 different galectin-9 splice variants in endothelial cells, 2 of which result in truncation of the C-terminal carbohydrate recognition domain and one of which has not been described previously i.e. galectin-9Δ5/6/10. By real-time PCR analysis we confirmed the expression of these 5 splice variants in endothelial cells and found that galectin-9Δ5 is the dominant splice variant in endothelial cells, as has been described for most other cell types. Endothelial cell activation resulted in a decreased expression of total galectin-9 levels which was mainly due to a decrease in galectin-9Δ5 expression. The expression of 2 other splice variants, galectin-9Δ5/6 and galectin-9Δ5/6/10 was retained after cell activation. To study the functional consequences of alternative splicing patterns on endothelial cell function, we cloned the 5 endothelial galectin-9 splice variants into expression constructs. We were able to demonstrate efficient transcription/translation of galectin-9 splice variants by real time PCR and Western blot respectively, following transfection of cell lines from non-endothelial (HEK293T) and endothelial (HMEC) origin. These data confirmed that exclusion of exon 10 causes a frameshift and premature stopcodon, resulting in the generation of protein that lacks the C-terminal CRD. Next, we assessed the function of gal-9 splice variants in endothelial cells by determining the effects on endothelial cell proliferation, migration and sprouting. Finally, we explored whether these splice variants have diverging roles in regulating the interaction between endothelial cells and immune cells. In conclusion, we report that endothelial cells express 5 splice variants of gal-9, one of which has not been described previously, and we show that these splice variants have diverging roles in endothelial cell biology. We hypothesize that interfering with the function of endothelial gal-9 splice variants might be an interesting approach for novel anti-cancer therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3490. doi:10.1158/1538-7445.AM2011-3490
The expressions of ZEB2 and E-cadand in cervical cancer cells and their relationship with the stage of disease

Field: Medicine (Health Sciences)

Objective: To investigate the relationship between the expressions of zinc finger E-box-binding protein 2(ZEB2) and E-cadherin(E-cad) in cervical cancer cells and the stages of disease. Methods: Sixty-two cases of squamous cervical cancer tissue diagnosed in the department of pathology of our hospital from June 2007 to November 2012 were selected. The expressions of ZEB2 and E-cad were detected by immunohistochemical method. Clinical data were retrospectively analyzed. The relationship between the expressions and the stages of disease was analyzed by single factor and multiple factors(logistic regression analysis). Ten cases of normal tissue adjacent to carcinoma were selected as a control. Results: The positive rate of ZEB2 expression in the tissues of squamous cervical carcinoma was higher than that in the cancer mucosa tissue adjacent to carcinoma while the positive rate of E-cad expression was lower(P0.05). The results of single factor analysis showed that ZEB2 and E-cad expressions were related to cervical cancer FIGO staging, differentiation degree and lymph node metastasis(P0.05). The results of logistic regression analysis showed that ZEB2 and E-cad expressions, FIGO staging and lymph node metastasis can be used as the factors for the stages of cervical cancer. Conclusion: ZEB2 and E-cad expressions are of benefit to the determination of the situation of the development, invasion and metastasis of cervical cancer and the development of prognosis program, which can be expected to become the index of staging cervical cancer.
Lipopeptides from the Tropical Marine Cyanobacterium Symploca sp.

Field: Chemistry (Physical Sciences)

A collection of the tropical marine cyanobacterium Symploca sp., collected near Kimbe Bay, Papua New Guinea, previously yielded several new metabolites including kimbeamides A-C, kimbelactone A, and tasihalide C. Investigations into a more polar cytotoxic fraction yielded three new lipopeptides, tasiamides C-E (1-3). The planar structures were deduced by 2D NMR spectroscopy and tandem mass spectrometry, and their absolute configurations were determined by a combination of Marfey's and chiral-phase GC-MS analysis. These new metabolites are similar to several previously isolated compounds, including tasiamide (4), grassystatins (5, 6), and symplocin A, all of which were isolated from similar filamentous marine cyanobacteria.
SPACE–TIMES WITH INTEGRABLE SINGULARITY: BLACK–WHITE HOLES AND ASTROGENIC UNIVERSES

Field: Physics and Astronomy (Physical Sciences)

We use the phenomenological approach to study properties of space–time in the vicinity of the Schwarzschild black-hole singularity. Requiring finiteness of the Schwarzschild-like metrics we come to the notion of integrable singularity that is, in a sense, weaker than the conventional singularity and allows the (effective) matter to pass to the white-hole region. This leads to a possibility of generating a new universe there. Thanks to the gravitational field of the singularity, this universe is already born highly inflated ("singularity-induced inflation") before the ordinary inflation starts.
The Effect of Sustainable Development Education-based Design Classes on Creative Problem-Solving Skills of 3rd Grade Middle School Students

Field: Arts and Humanities (Social Sciences)

지속가능발전은 미래 세대에게 더 나은 세상을 제공하는 범지구적 발전 양식으로, 교육을 통해 시작되는 사회변화에 중요한 역할을 한다. 본 연구는 교육부의 교육과정 개정을 반영하여, 지속가능발전 교육을 기반으로 한 디자인 수업이 중학교 3학년 학생들의 창의적 문제 해결 능력에 미치는 영향을 살펴보고자 하였다. 서울시 S 중학교 3학년 106명을 선정하여 단일집단으로 연구 대상을 설정하였으며, 문헌적 고찰을 바탕으로 지속가능발전교육의 6차시 연구수업을 제시하였다. 이어서 창의적 문제해결력(CPSPI) 사전·사후 검사를 수집 후 분석하였다. 또한, 수업의 효과성을 검증하기 위하여 수업 결과물, 수업 만족도, 학생인터뷰 내용에 대한 질적 분석을 진행하였다. 분석 결과, 지속가능발전교육을 기반으로 한 디자인 수업은 학생들의 창의적 문제 해결 능력 및 지속가능발전에 대한 인식 향상에 긍정적인 영향을 미쳤다. 이러한 분석 결과를 통해 학생들이 지속 가능한 발전에 대한 인식과 실천 능력, 그리고 문제 해결 능력에서 긍정적인 변화를 가져왔다는 것을 확인할 수 있었다. 본 연구의 통찰을 기반으로 앞으로의 미술교육 현장에서 지속가능발전교육을 토대로 한 프로그램이 더욱 많이 개발되어 학교 현장에 보급되기를 기대한다.