jimnoneill/paper-to-field-training huggingface dataset:
STRESS AND ANXIETY IN GENERAL POPULATION IN ROMANIA DURING COVID-19 PANDEMIC

Field: Psychology (Social Sciences)

The mental health challenges associated with the COVID-19 pandemic overwhelmingly affect the general population. Stress and health anxiety, the risk of losing a job and working at home, online education for children, and isolation have a devastating cumulative effect. This study aims to achieve the following: i) to identify the epidemiological specifics of the perceived stress levels in the general population during the COVID-19 pandemic; ii) to evaluate the correlation between socioeconomic factors and the level of perceived stress and anxiety; iii) to analyze the correlation between the perceived stress scores and the anxiety scores in the general population. We applied Perceived Stress Score (PSS) validated questionnaire and Hamilton Anxiety Scale (HAM-A) online to a group of respondents (N=1.362), profiling the data based on demographics: age, sex, COVID-19 infection, behavior compliance to sanitary limitations, socioeconomic status, and pre-existing health issues. Results show differentiation of PSS values in female and male respondents; occupation significantly influences the perceived stress score among COVID-19 positive respondents. Educational level and income significantly influence the perceived stress score. Low educational level and low income increase the perceived stress score among negative COVID-19 respondents. Subsequent research is needed to clarify other correlations between the perceived stress levels and general population well-being. While certain life conditions enhance the perception of stress, others could provide protective value to demographic groups. Therefore, we suggest further studies and qualitative approaches to general population stress and anxiety during the COVID-19 pandemic.
Program of community integration: in the search for new strategies and new ways of life

Field: Health Professions (Health Sciences)

The Program of Community Integration of the Municipal Bureau of Health of the city of Ribeirão Preto aims at promoting health, directing its actions for the change of life styles. The purpose of this study is to look, in the light of the framework of Health Promotion and through declarations of users of the program, how it has been formed as an important strategy to increase the autonomy and emancipation of the population. The analysis reveals that the program has improved the autonomy and emancipation of the population, as an important instrument for life defence.
Evaluative criteria for sleepwear: A study of privately consumed product in the People’s Republic of China

Field: Business, Management and Accounting (Social Sciences)

<p>The purpose of this study is to explore and investigate Chinese male consumers’ perceptions and behaviours towards low involvement and privately consumed product – pyjamas. According to our literature review, little research has been devoted to this particular topic. In this study, multiple product cues were used to measure and uncover what constitute consumers’ evaluation and purchase decisions. The questionnaire survey for this study was conducted in a second-tier city by using the convenience sampling method. In total, 256 useable questionnaires were collected and analysed. This study shows evidence that a majority of the Chinese male respondents did not wear pyjamas for sleeping. The intrinsic cues of sleepwear were ranked relatively higher than extrinsic cues, and the comfort cue was the most important criterion for product evaluation. Further research on this topic focusing on different products, samples and cities are recommended. The findings of this study provide insight and implications for fashion practitioners to develop their product and business in China.</p>
Small Hardware Design for Ease of Maintenance and Inspection.

Field: Engineering (Physical Sciences)

The small hardware problems of eight helicopters were reviewed in this program to find common aircraft reliability problems specifically occurring as the result of maintenance actions. Deficiencies of the hardware and the installation were defined. Design principles and concepts to reduce further helicopter reliability and maintainability problems were developed. Airframe hardware and furnishing attachments made up the majority of components studied. Fittings, clamps and other small components in the hydraulic, electrical, pneumatic and fuel systems were also reviewed. Phase I consisted of the indentification of problems by a review of the maintenance data reporting systems and the interrogation of helicopter maintenance personnel and field service representatives. During Phase II, a state-of-the-art hardware survey was conducted to determine if new concept development was required. Candidate replacement hardware was selected for each problem area. In Phase III, present components and candidate replacement components were subjected to a variety of tests, among which were endurance, vibration, environment, maintenance abuse, and static strength tests.
Scientific Opinion on the safety and efficacy of L-valine (ValAMINO®) produced by Corynebacterium glutamicum (DSM 25202) for all animal species, based on a dossier submitted by Evonik Industries AG

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The product L-valine, feed grade (ValAMINO®), is a feed additive produced by fermentation with a genetically modified strain of Corynebacterium glutamicum (DSM 25202). Neither the production strain nor its recombinant DNA was detected in the final product. Therefore, the final product does not give rise to any safety concerns with regard to the genetic modification. The additive L-valine, feed grade, produced by C. glutamicum (DSM 25202) is safe for all target animals when supplemented in appropriate amounts to feed to compensate for valine deficiency in feedingstuffs. The composition of tissues and products of animal origin will not be changed by the use of L-valine, feed grade, in animal nutrition. Considering the high purity of the product under assessment, no risks to the consumer are expected from its use as a feed additive. In the absence of specific data on user safety for the product under application, it would be prudent to consider it as an irritant to the skin, eyes and mucous membranes and as a potential dermal sensitiser. In the absence of any data on inhalation toxicity, the product is also regarded as potentially harmful by inhalation. The amino acid L-valine is a natural component of proteins of living organisms. Therefore, the use of the highly purified product L-valine, feed grade, in animal nutrition does not pose a risk to the environment. The product L-valine, feed grade, is an efficacious source of supplemented amino acid for all species, but it has a low efficiency in ruminants unless it is used in a protected form.
PENERAPAN SANKSI ADAT DALAM PENYELESAIAN TINDAK PIDANA PERJUDIAN DI KABUPATEN PESISIR SELATAN (STUDI KASUS PADA SATRESKRIM POLRES PESISIR SELATAN)

Field: Social Sciences (Social Sciences)

The practice of gambling is growing day by day in various levels of society, from the lower classes to the upper classes. This was proven when the Pesisir Selatan Criminal Investigation Unit (Sat Reskrim) arrested 7 (seven) mothers who played playing card gambling in Kampung Samudera, Kenagarian Surantih, Sutera District, Pesisir Selatan on October 21, 2017. But before taking the route criminal law in general, this case has been resolved by customary law in Pesisir Selatan by receiving customary sanctions. This research is a descriptive analytical study. The approach used in this study is a normative juridical approach supported by an empirical juridical approach. From the results of the research it can be explained that: First, the application of customary sanctions in the settlement of gambling crimes in Pesisir Selatan Regency, is by considering local rules and discretion made by the Head of Criminal Investigation Unit of the Pesisir Selatan Police. Where deliberation leaders, traditional, religious and family leaders hold a meeting, the results of the deliberation are conveyed to the police so that the suspects will be given customary sanctions, in the form of requiring them to walk from the location of arrest to one of the mosques, and vowing not to repeat the act again. Second, the obstacles to the application of customary sanctions in solving gambling crimes in Pesisir Selatan Regency are internal obstacles to the police and external obstacles to the police. There are settlement steps that can be taken in overcoming the obstacles that occur in overcoming gambling with preventive and repressive measures.
Teacher’s Qualification and Dyslexia Identification in Primary Schools in Oyo State, Nigeria

Field: Social Sciences (Social Sciences)

The study examined the relationship between teachers' qualifications and dyslexia identification in primary schools in Oyo State, Nigeria. Data were collected through the use of a well-structured questionnaire – the Teacher Dyslexia Awareness Checklist – administered to 147 primary school teachers in the state. Data were analysed using descriptive statistics, Principal Component Analysis (PCA), ANOVA and correlation coefficient. Demographic characteristics of teachers reveal that more female than males are engaged in the teaching profession with majority holding a National Certificate of Education (NCE) with more than 20 years teaching experience. The PCA shows that the level of knowledge of dyslexia among the teachers is low, as only 31% were knowledgeable about dyslexia. Results further show that the relationship between teachers' qualifications and teaching experiences is weak implying that teachers' qualifications and teaching experience are independent of each other. Thus, teachers' knowledge about dyslexia is not in relation to their qualification or teaching experiences. It is recommended that teachers undergo periodic in-service training on the manifestation and management practices for learning disabilities at least once a term and formal testing to assist them in identifying different types of psychological issues affecting pupils, as early identification of learning disabilities (such as dyslexia) is the best way to curtail their lifelong effects.
The Use of Mersilene® Mesh in Repair of Abdominal Wall Hernias

Field: Medicine (Health Sciences)

Use of synthetic materials in herniplasty has been a controversial issue. In order to determine the influence of Mersilene mesh on the strength of healing abdominal wounds and its effectiveness in repair of hernia, experimental and clinical studies were undertaken. Experimental study included 175 male rats divided into three groups subjected to either: 1) an incision made only through the skin and closed with 3-0 silk sutures; 2) a 2.5 cm midline incision through the musculature and peritoneum closed with 2-0 Mersilene suture; or 3) the same procedure as group 2 with the addition of a Mersilene mesh onlay graft. Bursting strength of abdominal wounds as determined in all groups at intervals. Wounds of the group treated with the mesh exhibited significantly greater (P less than 0.01) bursting strength. Clinical trial consisted of 100 consecutive adult patients in which an onlay graft of Mersilene mesh was used in the hernioplasty. Mesh was used as an adjunct in patients with: 1) large ventral hernias; 2) direct hernias resulting from severely attenuated transversialis fascia; 3) indirect hernias associated with a large internal ring and a weak posterior inguinal wall; or 4) combined direct and indirect hernias. All were followed for a minimum of one year to determine the incidence of complication and rate of recurrence. This study suggests that: 1) Mersilene mesh increases the strength of healing abdominal wounds in rats; and 2) repair of large hernias with Mersilene mesh results in an acceptable morbidity and a lowered rate of recurrence.
Synthesis and Characterization of Poly(Lactic-Co-Glycolic Acid)–Paclitaxel (PLGA-PTX) Nanoparticles Evaluated in Ovarian Cancer Models

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

We developed a novel biodegradable poly(lactic-co-glycolic acid) (PLGA) polymer chemically modified with paclitaxel (PTX) to form a PLGA-PTX hybrid. Pre-modification of PTX enhanced its loading in PLGA-PTX nanoparticles (NPs). Background/Objectives: PTX is one of the most effective chemotherapy agents used in cancer therapy. The primary mode of PTX’s action is the hyperstabilization of microtubules leading to cell growth arrest. Although highly potent, the drug is water insoluble and requires the Cremophor EL excipient. The toxic effects of the free drug (e.g., neurotoxicity) as well as its solubilizing agent are well established. Thus, there is strong clinical rationale and need for exploring alternative PTX delivery approaches, retaining biological activity and minimizing systemic effects. Methods: The PTX modification method features reacting the C-2′ and C-7 residues with a linker (succinic anhydride) to produce easily accessible carboxyl groups on the PTX for enhanced coupling to the hydroxyl group of PLGA. The PLGA-PTX hybrid, formed via esterification reaction, was used to formulate lipid-coated PLGA-PTX NPs. As proof of concept, the PLGA-PTX NPs were tested in ovarian cancer (OvCA) models, including several patient-derived cell lines (PDCLs), one of which was generated from a platinum-resistant patient. Results: The PLGA-PTX NPs critically remained stable in water and serum while enabling slow drug release. Importantly, PLGA-PTX NPs demonstrated biological activity. Conclusions: We suggest that this approach offers both a new and effective PTX formulation and a possible path towards the development of a new generation of OvCA treatment.
Prevalence of unsuspected abnormal echocardiograms in adolescents with down syndrome

Field: Medicine (Health Sciences)

Abstract The purpose of this article is to describe the prevalence of cardiac disease previously undiagnosed in healthy asymptomatic children and adolescents with Down syndrome (DS). Subjects with DS ages 10–20 years were recruited from two sites, the Children's Hospital of Philadelphia (Philadelphia, PA) and Children's National Health System (Washington, DC) for a cross‐sectional study of body composition and cardiometabolic risk. Echocardiographic and clinical data were collected from patients enrolled in the parent study of cardiometabolic risk. Nine (6%) new cardiac diagnoses were identified out of 149 eligible patients. All new findings resulted in outpatient referrals to pediatric cardiology. Current guidelines recommend screening all newborns with DS for congenital heart disease. Older patients with DS may benefit from rescreening.
Local ocular surface findings in COVID-19 patients without ocular symptoms

Field: Medicine (Health Sciences)

ABSTRACT Purpose: To investigate subjective ocular symptoms and objectively measure tear secretion in patients with a confirmed diagnosis of coronavirus disease-2019 (COVID-19). Methods: In this prospective cross-sectional study, 24 patients who had survived COVID-19 infection and 27 healthy controls were enrolled. Conjunctival impression cytology, the Schirmer test, tear-film break-up time, corneal staining scores were applied to all the participants. Results: No significant difference was noted with regard to the gender and mean age between the two groups (p=0.484 and p=0.599, respectively). The conjunctival impression cytology analysis revealed that the density of the goblet cells was decreased, while the counts of lymphocytes and neutrophils were increased in the COVID-19 group patients when compared with ethe control group patients. When the Nelson classification was applied to the conjunctival impression cytology samples, 25% of the COVID-19 group patients and 14.8% of the control group patients exhibited changes consistent with ≥grade 2. The mean tear-film break-up time, Schirmer test, and corneal staining score results were determined to differ between the COVID-19 and control groups (p=0.02, p<0.001, and p=0.003, respectively). Conclusions: The present study revealed the pathological conjunctival alterations of patients with a confirmed diagnosis of COVID-19, indicating the possibility of the occurrence of pathological ocular surface alterations to even at the end of COVID-19 infection, without the occurrence of any significant clinical ocular manifestations.
An Atomically Layered InSe Avalanche Photodetector

Field: Materials Science (Physical Sciences)

Atomically thin photodetectors based on 2D materials have attracted great interest due to their potential as highly energy-efficient integrated devices. However, photoinduced carrier generation in these media is relatively poor due to low optical absorption, limiting device performance. Current methods for overcoming this problem, such as reducing contact resistances or back gating, tend to increase dark current and suffer slow response times. Here, we realize the avalanche effect in a 2D material-based photodetector and show that avalanche multiplication can greatly enhance the device response of an ultrathin InSe-based photodetector. This is achieved by exploiting the large Schottky barrier formed between InSe and Al electrodes, enabling the application of a large bias voltage. Plasmonic enhancement of the photosensitivity, achieved by patterning arrays of Al nanodisks onto the InSe layer, further improves device efficiency. With an external quantum efficiency approaching 866%, a dark current in the picoamp range, and a fast response time of 87 μs, this atomic layer device exhibits multiple significant advances in overall performance for this class of devices.
Elucidation of the intrinsic loss arising from switch output capacitance Coss in ultra-high-speed low-loss power converters

Field: Engineering (Physical Sciences)

Attempts to drive down the switching losses of hard-switched unipolar devices by increasing gate drive current levels are ultimately limited by the device output capacitance, which thus represents an intrinsic loss. The paper presents an in-depth analysis of the charging and discharging of the output capacitance and the associated loss producing mechanisms. It is shown that energy is stored in the depletion layer of the device during turn-off and then dissipated as heat during the turn-on process. The instantaneous power dissipated in the device is thus different to the instantaneous power loss measured at the device terminals, although the total energy loss over one complete turn-off and turn-on cycle is still faithfully reproduced. An analytical approach to determining the intrinsic switching loss due to the output capacitance is presented and verified by experimental results and by TCAD simulation. It is shown that around 20% of the total switching losses arise from the intrinsic output capacitance loss under fast-switched inductive load conditions. A comparison of Si and SiC FET devices demonstrates the potential for SiC power devices to provide an energy efficient option for very high frequency switching.
Aid Dependency and Political Settlements in Afghanistan

Field: Social Sciences (Social Sciences)

Afghanistan is highly aid dependent. Aid dependency is defined as when aid comprises around 10% of GDP and when in the absence of aid the state fails to perform many of its core functions (Bizhan, 2018b, p. 1016). The World Bank (2018) estimates that international aid currently comprises 40% of Afghanistan’s GDP. Afghanistan is dependent on international aid to maintain state functions (Strand et al., 2017, p. 46). Donors have warned the Afghan government that aid levels will decline in the future. Aid levels are expected to approximately halve by 2030 (reducing from 40% of GDP to 20%). There is consensus in the literature that Afghanistan is aid dependent and also that it is sensitive to changes in international aid. For example, analysts agree that the slowdown in economic growth in 2013-2015 was due to the combination of declining international aid, the drawdown of international forces and the 2014 Presidential election. The literature reviewed for this report agrees that continuing international aid is needed to protect the gains made in Afghanistan since 2002. This is due to the low resilience of the Afghan state, which makes its economy and political system highly sensitive to shocks. Afghanistan is a fragile state and a number of reforms would be needed to help the state move towards self-reliance. However, literature searches for this report were unable to identify any projections concerning the minimum level of international aid needed to sustain the state’s ability to function.
Analytical expression for the tunnel current through the redox-mediated tunneling contact in the case of the adiabatic electron transfer at one of the working electrodes and any possible type of the electron transfer at the other electrode

Field: Physics and Astronomy (Physical Sciences)

We study the tunnel current through a one-level redox molecule immersed into the electrolyte solution for the case when the coupling of the molecule to one of the working electrodes is strong while it is arbitrary to the other electrode. Using the Feynman-Vernon influence functional theory and the perturbation expansion of the effective action of the classical oscillator coupled both to the valence level of the redox molecule and to the thermal bath representing the classical fluctuations of the polarization of the solvent, we obtain, following the canonical way, the Langevin equation for the oscillator. It is found that for the aqueous electrolyte solution, the damping and the stochastic forces which arise due to the tunnel current are much smaller than those due to the thermal bath and therefore can be neglected. We estimate the higher-order corrections to the effective action and show that the Langevin dynamics takes place in this case for arbitrary parameters of the tunneling junction under the condition of the strong coupling of the redox molecule to one of the working electrodes. Then the steady-state coordinate distribution function of the oscillator resulting from the corresponding Fokker-Planck equation is the Boltzmann distribution function which is determined by the adiabatic free energy surface arising from the mean current-induced force. It enables us to obtain the expression for the tunnel current in the case when the coupling of the redox molecule to one of the working electrodes is strong while it is arbitrary to the other electrode.
Intraventricular CCK-8 reduces single meal size in the baboon by interaction with type-A CCK receptors

Field: Neuroscience (Life Sciences)

Intraventricular cholecystokinin COOH-terminal octapeptide (CCK-8) decreases meal size in the meal-trained baboon. In the present study, we tested whether this action is mediated by CCK-A receptors, CCK-B receptors, or both. Intraventricular administration of the selective CCK-A receptor agonist A71623 at 1 and 10 nmol/kg suppressed 30-min meal size 69 +/- 22% and 75 +/- 7%, respectively. Additionally, intraventricular A71623 was equipotent to CCK-8 at 1 nmol/kg (% suppression of meal by CCK = 59 +/- 17). However, intraventricular administration of the CCK-B receptor agonist A63387 at 10 nmol/kg had no effect on 30-min meal size (% suppression = 18 +/- 29). Intravenous administration of 10 nmol/kg A71623 did not result in an alteration of meal size, but prandial plasma insulin and glucose responses were delayed and blunted. Basal plasma insulin levels doubled after intravenous administration of A71623. Both behavioral and metabolic responses to A71623 in the baboon are virtually identical to those we have previously observed after CCK-8 treatment. Thus we conclude that the predominant receptor population with which intraventricular CCK-8 interacts are type-A CCK receptors that are accessible to the ventricular system of the baboon.