jimnoneill/paper-to-field-training huggingface dataset:
[Prosthesis exchange with a cement-free ceramic prosthesis].

Field: Medicine (Health Sciences)

Representation of the causes of failure of cemented total hip prostheses concerning long-term-results due to wear problems and cement destruction. In order to avoid a further weakening of bony structures we recommend the use of the self-locking Autophor-prosthesis (Mittelmeier) in case of revision. At the same time additional bone-grafting for better ingrowth of the prosthesis often becomes necessary. By means of the casuistry of our clinic (1975-1983) with altogether 102 revision cases with self-locking Autophor-prostheses we represent the results. With the exception of 5 failure cases these results were very satisfactory.
A connected community response to COVID-19 in Toronto

Field: Health Professions (Health Sciences)

In this commentary, we describe initial learnings from a community-based research project that explored how the relational space between residents and formal institutions in six marginalised communities in Toronto, Ontario, Canada impacted grassroots responses to the health and psycho-social stresses that were created and amplified by the coronavirus disease 2019 (COVID-19) pandemic. Our research found that grassroots community leaders stepped up to fill the gaps left by Toronto’s formal public health and emergency management systems and were essential for mitigating the psycho-social and socioeconomic impacts of the pandemic that exacerbated pre-existing inequities and systemic failures. We suggest that building community resilience in marginalised communities in Toronto can embody health promotion in action where community members, organisational, institutional and government players create the social infrastructure necessary to build on local assets and work together to promote health by strengthening community action, advocating for healthy public policy and creating supportive environments.
Nuclear magnetic resonance spectra of some β-diketone complexes of group III and IV elements

Field: Chemistry (Physical Sciences)

The chemical shifts of the CH and CH3 protons in the nuclear magnetic resonance spectra of many neutral β-diketone complexes are shown to be sensitive to the electrical symmetry of the molecule. The effects are ascribed largely to intramolecular linear electric-field shifts and can be calculated from the dipole moment of the molecule. The signs of the shifts can be used in discussing the structure of the complexes; they confirm the cis configuration for titanium(IV), germanium(IV), and tin(IV) complexes of the type M(acac)2Cl2, and the existence of two C-bonded (acac) ligands in [Pt(acac)3]–. The large low-field shift of CH recently observed in [Si(acac)3]+ is also ascribed to both first- and second-order electric-field shifts rather than to any marked benzenoid resonance in the β-diketone ring.
Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Targeted cancer therapy has become one of the high potential cancer treatments. Human topoisomerase II (hTopoII), which catalyzes the cleavage and rejoining of double-stranded DNA, is an important molecular target for the development of novel cancer therapeutics. In order to diversify the pharmacological activity of chalcones and to extend the scaffold of topoisomerase inhibitors, a series of chalcones was screened against hTopoIIα by computational techniques, and subsequently tested for their in vitro cytotoxicity. From the experimental IC50 values, chalcone 3d showed a high cytotoxicity with IC50 values of 10.8, 3.2 and 21.1 µM against the HT-1376, HeLa and MCF-7 cancer-derived cell lines, respectively, and also exhibited an inhibitory activity against hTopoIIα-ATPase that was better than the known inhibitor, salvicine. The observed ligand–protein interactions from a molecular dynamics study affirmed that 3d strongly interacts with the ATP-binding pocket residues. Altogether, the newly synthesised chalcone 3d has a high potential to serve as a lead compound for topoisomerase inhibitors.
Molybdenum cofactor deficiency

Field: Medicine (Health Sciences)

Molybdenum cofactor (MoCo) deficiency presents classically in the neonatal period, with convulsions intractable to anticonvulsant therapy and coma. The clinical manifestations of MoCo deficiency relating to the nervous system are generally considered to be functions of the deficiency of sulfite oxidase. Deficiency of xanthine oxidase leads to elevations in levels of xanthine, as well as hypouricemia. Xanthine is highly insoluble, and this leads to urinary tract calculi, hematuria, renal colic, and infection. Urinary excretion of sulfite, thiosulfate, S-sulfocysteine, and taurine were increased. There was hypouricemia and decreased excretions of uric acid and sulfate. The primary defect was deficient synthesis of the MoCo. Six patients with MoCo deficiency have been treated with this intermediate, now known as cyclic pyranopterin monophosphate. All were type A and had mutations in MOCS1 which causes a loss of cyclic pyranopterin monophosphate, the first intermediate in the pathway of molybdopterin synthesis.
The Effects of Benomyl on the Growth and Development of Wheat1

Field: Agricultural and Biological Sciences (Life Sciences)

Wheat crops treated with benzimidazole‐containing fungicides have often shown small increases in yield in the absence of any detectable disease. This project was designed to test the possibility that direct physiological effects of the fungicide were responsible. The major effect of benomyl, at concentrations in the range 200–5000 ppm was to increase the development of tillers. Spraying at any one of several stages of development caused an increase in the number of tillers detected about 6 weeks later. This was found to be due to a more rapid initiation of tillers and not to more rapid growth following initiation. Associated with this earlier initiation was an increase in the incorporation of C14‐labelled assimilates into newly initiated tiller buds, but not into older ones. These responses resemble those reported for the effects of cytokinin applications to cereals. In field experiments, the increase in tiller production caused an increase in ear number only when plants were widely spaced. The decrease in tiller number as plant density increased was more rapid in treated plants than in controls, so that both treatments produced similar ear densities at around optimum plant density.
Application of Food Additives in Frozen Buckwheat Dumpling

Field: Agricultural and Biological Sciences (Life Sciences)

The quality of frozen Buckwheat dumpling may be affected by the raw materials, processing technology or other factors. Collapsed degree, frozen cracking rate and other sensory quality were the main problem during processing. The food additives were usually used to improve the quality of frozen dumpling. In this paper, the best formula of monoglycerides, xanthan gum, CMC, and the buckwheat flour were determined by the single factor experiments and orthogonal test. The results showed that the optimal formula was CMC 0.3%, xanthan gum 0.15%, monoglycerides 0.3% and buckwheat flour 30%. Under this best formula the collapsed degree, frozen cracking rate had been greatly reduced and the sensory quality improved.
Geometallurgical Responses on Lithological Domains Modelled by a Hybrid Domaining Framework

Field: Earth and Planetary Sciences (Physical Sciences)

Identifying mineralization zones is a critical component of quantifying the distribution of target minerals using well-established mineral resource estimation techniques. Domains are used to define these zones and can be modelled using techniques such as manual interpretation, implicit modelling, and advanced geostatistical methods. In practise, domaining is commonly a manual exercise that is labour-intensive and prone to subjective judgement errors, resulting in a largely deterministic output that ignores the significant uncertainty associated with manual domain interpretation and boundary definitions. Addressing these issues requires an objective framework that can automatically define mineral domains and quantify the associated uncertainty. This paper presents a comparative study of PluriGaussian Simulation (PGS) and a Hybrid Domaining Framework (HDF) based on simulated assay grades and XGBoost, a machine-learning classification technique trained on lithological properties. The two domaining approaches are assessed on the basis of the domain boundaries produced using data from an Iron Oxide Copper Gold deposit. The results show that the proposed HDF domaining framework can quantify the uncertainty of domain boundaries and accommodate complex multiclass problems with imbalanced features. Geometallurgical models of the Net Smelter Return and grinding time are used to demonstrate the effectiveness of HDF. In addition, a preprocessing step involving a noise filtering method is used to improve the performance of the ML classification, especially in cases where domain boundaries are difficult to predict due to the similarity in geological characteristics and the inherent noise in the data.
Newer pharmacologic approaches targeting receptors and genes

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Introduction The term "peripheral arterial disease" (PAD) covers a multitude of disorders involving arterial beds exclusive of the coronary arteries. There are numerous pathophysiologic processes that could contribute to the creation of stenoses or aneurysms of the noncoronary arterial circulation. Atherosclerosis represents the leading disease process affecting the aorta and its branch arteries. Patients undergoing percutaneous coronary intervention (PCI) who have PAD have been shown to have worse short-and long-term outcomes compared to patients without PAD (1-3). This chapter will cover pharmacotherapy and nonpharmacologic therapies for PAD involving lower extremities.
Influence of Some Plant Extracts on Antifungal Properties, Hardness, and Peel Bond Strength of Heat-Cured Denture Soft Liner

Field: Dentistry (Health Sciences)

Background: Soft liners in dentures play a crucial role in enhancing patient comfort and preventing tissue irritation especially for patients with resorbed ridges. However, microbial colonization presents a challenge to their long-term effectiveness, particularly Candida albicans, leading to conditions like denture-induced stomatitis. Objective: To evaluate the antimicrobial efficacy and mechanical properties of heat cured soft liners incorporating plant extracts from Olea europaea and Ficus carcia, individually and synergistically. Patients and Methods: Extracts were obtained through Soxhlet extraction, and their antimicrobial activity against Candida albicans was determined using the broth microdilution method. Soft liner specimens were prepared with varying concentrations of the extracts and subjected to disk diffusion tests, shore A hardness measurements, and peel bond strength tests. Statistical analysis involved the use of one-way ANOVA and Dunnett tests. Results: Results demonstrated significant antimicrobial activity, with the synergistic mixture exhibiting the highest inhibition zone against Candida albicans. Moreover, the addition of such extracts led to increased shore A hardness, with the highest levels recorded for synergistic groups. The extracts also displayed a significant decrease in peel bond strength, indicating potential challenges in adhesive properties. These findings suggest that while individual extracts show promise in antimicrobial efficacy and mechanical reinforcement of soft liners, their combination may lead to compromised adhesive properties. Conclusion: The study contributes valuable insights into the development of antimicrobial soft liners reinforced with Olea europaea and Ficus carcia extracts, advancing dental materials towards improved patient outcomes and enhanced oral health.
Tongue nodules in an atypical canine leishmaniasis in Brazil

Field: Veterinary (Health Sciences)

We aimed to report a case of canine leishmaniasis with the only visible clinical sign being the presence of nodules in the lateral region of the tongue. The bitch was treated for a mandibular fracture, when multiple small nodules were observed on the tongue. We identify nodular glossitis with the presence of structures compatible with amastigote forms of Leishmania. The bitch was positive by ELISA, RIFI and PCR assays. Clinical re-evaluation after one year of treatment for leishmaniasis showed clinical improvement, but there was maintenance of antibody titers and infectivity. Lingual nodules as the only clinical sign of the disease is rare, especially in endemic areas, but should be included as differential diagnosis for leishmaniasis in the country.
Enhancing Lysostaphin Thermostability and Utilizing Lysostaphin‐Producing Probiotics to Combat Staphylococcus aureus in Milk

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The emergence and spread of methicillin‐resistant Staphylococcus aureus (MRSA) is a major cause of bacterial infections in healthcare. Lysostaphin, a Zn 2+ ‐dependent endopeptidase, hydrolyzes the glycine (G)‐linked pentapeptide bridge in the pathogen Staphylococcus aureus . In this study, the stability of lysostaphin was improved by engineering the addition of disulfide bonds around the protein’s Zn 2+ binding site through molecular dynamics simulation. Further mutagenesis to add polyG at the C‐terminus yielded combination variant 319/252‐G 3 , which was 2.6‐fold more stable than lysostaphin after 30 min at 60°C. Optimization of the C‐terminal glycine number produced variant 319/252‐G 6 , which retained 67.3% of its antimicrobial activity after 30 min at 70°C, and could be resistant to milk pasteurization conditions. Based on this, a probiotic strain of Escherichia coli Nissle 1917 to constitutively express and secrete lysostaphin from a mutated lac operator was engineered, resulting in effective control and prevention of S. aureus contamination in milk. One possible biotechnological application to utilize lysostaphin and probiotic strains can be used in animal feed and food additives for the prevention and treatment of S. aureus infections.
Planning for a Corpus of Continuous Ratings of Spoken Dialog Quality

Field: Computer Science (Physical Sciences)

While many aspects of speech processing, including speech recognition and speech synthesis, have seen enormous advances over the past few years, advances in dialog have been more modest. This difference is largely attributable to the lack of resources that can support machine learning of dialog models and dialog phenomena. The research community accordingly needs a corpus of spoken dialogs with quality annotations every 100 milliseconds or so. We envisage a large and diverse collection: on the order of fifty hours of data, representing hundreds of speakers and many genres, with every instant labeled for interaction quality by one or more human judges. To make it maximally useful, its design will be a community effort.\nThis technical report is an edited version of a National Science Foundation proposal, submitted to the CISE Community Research Infrastructure Program in February 2019.
Judicial regulation of administrative policies that influence the exercise of statutory discretions

Field: Social Sciences (Social Sciences)

This paper argues that, in light of the prevalence of administrative policies, the normative force they carry and the reliance placed upon them by the public, there is a need for the courts to develop the law regulating the way that administrators use policy to structure and guide the exercise of their statutory discretions. It will be argued that such developments would give effect to both the 'controlling' and the 'facilitating' objectives that underpin administrative law, and, would strike an appropriate balance between the competing values at play so as to foster good governance. First, the nature2of administrative policies, their rise as a regulatory tool of government and the growing administrative preference for policy over delegated legislation are explored. It is argued that there is a necessity for the courts to develop the law regulating the administrative use of policy to foster the democratic principle of accountability. The current legal principles regulating the use of administrative policies in a discretionary context, under the broad banner of the 'fettering by rigidity principle' are explored and assessed. It is argued that the fettering by rigidity principle has been applied in a nuanced and variable way, and that it plays an important role in fostering good governance, particularly by promoting flexibility, responsiveness and participation, but does not go far enough in promoting the values of certainty, fairness and consistency. It is argued that a more appropriate balance between these values could be struck by developing a duty for administrators to apply policy consistently and only to depart for good reasons. Finally, it is argued that the principle of legitimate expectations should be developed to allow for substantive protection where an administrator unjustifiably frustrates the trust and reliance which individuals may have placed in an existing policy where that policy is subsequently replaced by a new one.
Epidermal growth factor receptor (EGFR)expression and role during human myoblast differentiation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Within skeletal muscles, myogenic stem cells - satellite cells - will proliferate and then, differentiate to build/re-build muscle fibers. In vitro, myoblasts derived from human satellite cells can be induced to differentiate after medium switch. Using this cellular model, we previously showed that one of the first steps of myoblast differentiation is a hyperpolarization of myoblasts' membrane. This change of membrane potential is followed by a calcium entry and the expression of myogenic transcription factors. More precisely, myoblast hyperpolarization relies on a potassium channel, Kir2.1 which is maintained inactive during proliferation. Here, EGF receptor, was identified as a stimulator of proliferation and an inhibitor of differentiation. EGFR expression is physiologically regulated in myoblasts and decreases during differentiation, in particular via the proteasome. Absence of EGFR results in a decrease of Kir2.1 phosphorylation, activation of this channel favoring calcium entry, expression of muscle-specific transcription factors and proteins.
PENGENALAN DASAR-DASAR AKUNTANSI BAGI SISWA RUMAH BELAJAR MAHKOTA KASIH INSANI

Field: Business, Management and Accounting (Social Sciences)

Education for the younger generation is very important in increasing knowledge, creating creativity, and developing self-potential. Therefore, the Mahkota Kasih Insani Learning House in addition to funding student's schools also collaborates with external parties to provide initial knowledge for students from the foster children of the MahkotaKasih Insani Learning House before facing learning activities at school. The collaboration is carried out by inviting lecturers and students of the Accounting Department, Faculty of Economics and Business, UniversitasTarumanagara, Jakarta to share knowledge in the field of accounting in community service activities. The purpose of this activity is to provide training on the introduction of the basics of accounting for students of the Mahkota Kasih Insani Learning House. The activity will be carried out on Saturday, July 3, 2021, offline with strict health protocols. This activity uses training methods regarding the introduction of accounting basics, accounting structures, basic accounting equations, and financial reports, as well as practice exercises about accounting basics. Based on the results of the activity evaluation, it can be concluded that community service activities run smoothly and give a good general impression for students because students can better recognize and understand the basics of accounting that are useful in dealing with learning activities in schools in the field of accounting.Pendidikan bagi generasi muda sangat penting dalam menambah pengetahuan, menciptakan kreativitas, dan mengembangkan potensi diri. Oleh karena itu, Rumah Belajar Mahkota Kasih Insani selain membiayai sekolah siswa juga bekerjasama dengan pihak eksternal memberikan pengetahuan awal bagi siswa dari anak asuh Rumah Belajar Mahkota Kasih Insani.sebelum menghadapi kegiatan belajar di sekolah. Kerjasama yang dilakukan dengan cara mengundang dosen dan mahasiswa Jurusan Akuntansi Fakultas Ekonomi dan Bisnis Universitas TarumanagaraJakarta untuk berbagi ilmu dibidang akuntansi dalam kegiatan pengabdian kepada masyarakat. Tujuan dari kegiatan tersebut adalah memberikan pelatihan pengenalan dasar-dasar akuntansi bagi siswa Rumah Belajar Mahkota Kasih Insani. Pelaksanaan kegiatan dilakukan pada hari Sabtu, 3 Juli 2021 secara luring dengan protokol kesahatan yang ketat. Kegiatan tersebut menggunakan metode pelatihan mengenai pengenalan dasar-dasar akuntansi, struktur akuntansi, persamaan dasar akuntansi, dan laporan keuangan, serta praktek latihan soal dasar-dasar akuntansi. Berdasarkan hasil evaluasi kegiatan, maka dapat disimpulkan kegiatan pengabdian kepada masyarakat berjalan dengan lancar dan memberikan kesan umum yang baik bagi siswa dikarenakan siswa dapat lebih mengenal dan memahami dasar-dasar akuntansi yang bermanfaat dalam menghadapi kegiatan belajar di sekolah dalam bidang akuntansi.
Plasmin and regulators of plasmin activity control the migratory capacity and adhesion of human T cells and dendritic cells by regulating cleavage of the chemokine CCL21

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The homeostatic chemokine CCL21 has a pivotal role in lymphocyte homing and compartment localisation within the lymph node, and also affects adhesion between immune cells. The effects of CCL21 are modulated by its mode of presentation, with different cellular responses seen for surface‐bound and soluble forms. Here we show that plasmin cleaves surface‐bound CCL21 to release the C‐terminal peptide responsible for CCL21 binding to glycosaminoglycans on the extracellular matrix and cell surfaces, thereby generating the soluble form. Loss of this anchoring peptide enabled the chemotactic activity of CCL21 and reduced cell tethering. Tissue plasminogen activator did not cleave CCL21 directly but enhanced CCL21 processing through generation of plasmin from plasminogen. The tissue plasminogen activator inhibitor neuroserpin prevented processing of CCL21 and blocked the effects of soluble CCL21 on cell migration. Similarly, the plasmin‐specific inhibitor α 2 ‐antiplasmin inhibited CCL21‐mediated migration of human T cells and dendritic cells and tethering of T cells to APCs. We conclude that the plasmin system proteins plasmin, tissue plasminogen activator and neuroserpin regulate CCL21 function in the immune system by controlling the balance of matrix‐ and cell‐bound CCL21.
High Pathogenicity Avian Influenza in the Americas

Field: Veterinary (Health Sciences)

This chapter contains sections titled: Introduction Fowl Plague in Northeastern and Upper Midwestern United States during 1924–1925 Fowl Plague in New Jersey, United States, During 1929 H5N9 High Pathogenicity Avian Influenza in Ontario, Canada, during 1966 H5N2 High Pathogenicity Avian Influenza in Northeastern United States during 1983 and 1984 H5N2 High Pathogenicity Avian Influenza in Mexico during 1994–1995 H7N3 High Pathogenicity Avian Influenza in Chile during 2002 H7N3 High Pathogenicity Avian Influenza in British Columbia,Canada, during 2004 H5N2 High Pathogenicity Avian Influenza in Texas during 2004 H7N3 High Pathogenicity Avian Influenza in Saskatchewan,Canada during 2007 Conclusions Acknowledgments References