jimnoneill/paper-to-field-training huggingface dataset:
Adjuvant Chemoradiotherapy With Epirubicin, Cisplatin, and Fluorouracil Compared With Adjuvant Chemoradiotherapy With Fluorouracil and Leucovorin After Curative Resection of Gastric Cancer: Results From CALGB 80101 (Alliance)

Field: Medicine (Health Sciences)

Purpose After curative resection of gastric or gastroesophageal junction adenocarcinoma, Intergroup Trial 0116 (Phase III trial of postoperative adjuvant radiochemotherapy for high risk gastric and gastroesophageal junction adenocarcinoma: Demonstrated superior survival for patients who received postoperative chemoradiotherapy with bolus fluorouracil (FU) and leucovorin (LV) compared with surgery alone. CALGB 80101 (Alliance; Phase III Intergroup Trial of Adjuvant Chemoradiation After Resection of Gastric or Gastroesophageal Adenocarcinoma) assessed whether a postoperative chemoradiotherapy regimen that replaced FU plus LV with a potentially more active systemic therapy could further improve overall survival. Patients and Methods Between April 2002 and May 2009, 546 patients who had undergone a curative resection of stage IB through IV (M0) gastric or gastroesophageal junction adenocarcinoma were randomly assigned to receive either postoperative FU plus LV before and after combined FU and radiotherapy (FU plus LV arm) or postoperative epirubicin, cisplatin, and infusional FU (ECF) before and after combined FU and radiotherapy (ECF arm). Results With a median follow-up duration of 6.5 years, 5-year overall survival rates were 44% in the FU plus LV arm and 44% in the ECF arm ( P logrank = .69; multivariable hazard ratio, 0.98; 95% CI, 0.78 to 1.24 comparing ECF with FU plus LV). Five-year disease-free survival rates were 39% in the FU plus LV arm and 37% in the ECF arm ( P logrank = .94; multivariable hazard ratio, 0.96; 95% CI, 0.77 to 1.20). In post hoc analyses, the effect of treatment seemed to be similar across all examined patient subgroups. Conclusion After a curative resection of gastric or gastroesophageal junction adenocarcinoma, postoperative chemoradiotherapy using a multiagent regimen of ECF before and after radiotherapy does not improve survival compared with standard FU and LV before and after radiotherapy.
Large-field lattice structured illumination microscopy

Field: Computer Science (Physical Sciences)

In this paper, we present large-field, five-step lattice structured illumination microscopy (Lattice SIM). This method utilizes a 2D grating for lattice projection and a spatial light modulator (SLM) for phase shifting. Five phase-shifted intensity images are recorded to reconstruct a super-resolution image, enhancing the imaging speed and reducing the photo-bleaching both by 17%, compared to conventional two-direction and three-shift SIM. Furthermore, lattice SIM has a three-fold spatial bandwidth product (SBP) enhancement compared to SLM/DMD-based SIM, of which the fringe number is limited by the SLM/DMD pixel number. We believe that the proposed technique will be further developed and widely applied in many fields.
Changing Sexual Attitudes in China, 2010 to 2021: An Age-Period-Cohort Analysis

Field: Social Sciences (Social Sciences)

Despite numerous studies on changing sexual attitudes in China, little is known about the distinct contributions of age, period, and cohort to these changes, and how sex disparities in attitudes evolved over periods and generations. This study used hierarchical age-period-cohort analysis on seven waves of Chinese General Social Survey data to address these gaps. Findings showed independent effects of age, period, and cohort. Attitudes toward premarital and same-sex activities grew more restrictive with age, while extramarital sex attitudes grew more restrictive in middle age, relaxing slightly in later years. From 2010 to 2021, attitudes toward premarital and same-sex activities became less restrictive, while extramarital sex attitudes remained stable. Significant attitudinal shifts occurred among those born before and after 1980. The post-1980 generation showed decreased restrictiveness toward premarital and same-sex sexual activities, but increased restrictiveness toward extramarital sex. The post-1990s generation exhibited increased restrictiveness regarding premarital sex. Sex disparities in attitudes toward premarital and same-sex activities differed across cohorts but remained steady over periods. Women were consistently more tolerant of same-sex sexual practices but more restrictive of premarital sex across most cohorts. Sex disparities in attitudes toward premarital and same-sex sexual behaviors widened among those born after 1975. This study provides explanations in the Chinese context and offers insights for future research and policies.
Printed in Great Britain THE EFFECTS OF DERIVATIVES OF ADENOSINE 3&apos;,5&apos;- MONOPHOSPHATE ON FLUID SECRETION BY THE SALIVARY GLANDS OF CALLIPHORA

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Fluid secretion by the salivary glands of the blowfly Calliphora is regulated by 5-hydroxytryptamine (5-HT) (Berridge, 1970, 1972; Berridge &amp; Prince, 1972). The action of 5-HT is apparently mediated by adenosine 3&apos;,5&apos;-monophosphate (cyclic AMP) which thus functions as an intracellular &apos;second messenger &apos; as has been
Quantum matching pursuit: A quantum algorithm for sparse representations

Field: Computer Science (Physical Sciences)

Representing signals with sparse vectors has a wide spectrum of applications that ranges from image and video coding to shape representation and health monitoring. In many applications with real-time requirements or that deal with high-dimensional signals, the computational complexity of the encoder that finds the sparse representation plays an important role. Quantum computing has recently shown promising speedups in many representation learning tasks. In this work, we propose a quantum version of the well-known matching-pursuit algorithm. Assuming the availability of a fault-tolerant quantum random access memory, our quantum matching pursuit lowers the complexity of its classical counterpart by a polynomial factor, at the cost of some error in the computation of the inner products, enabling the computation of sparse representations of high-dimensional signals. Besides proving the computational complexity of our algorithm, we provide numerical experiments that show that its error is negligible in practice. This work opens the path to further research on quantum algorithms for finding sparse representations, showing suitable quantum computing applications in signal processing.
Syntheses of Conjugated Pyrones for the Enzymatic Assay of Lovastatin Nonaketide Synthase, an Iterative Polyketide Synthase

Field: Chemistry (Physical Sciences)

[reaction: see text] Lovastatin nonaketide synthase (LovB, LNKS) is an iterative type I polyketide synthase (PKS) from Aspergillus terreus that produces dihydromonacolin L (2), the biosynthetic precursor of lovastatin (1), from acetyl CoA, malonyl CoA, and S-adenosylmethionine (SAM) if the accessory protein LovC is present. In the absence of LovC, LNKS forms the conjugated pyrones 3 and 4 as truncated PKS products. Short syntheses of these pyrones provide material for the assay of LNKS activity by HPLC and radioisotope dilution analysis.
One dose of preoperative, intravenous, prophylactic antibiotics significantly lowers postoperative infection rate in septoplasty—a study of 772 operations

Field: Medicine (Health Sciences)

Abstract Objectives Postoperative infection is the most common complication after septoplasty. Pre‐ or postoperative prophylactic antibiotics are commonly used, although no official guidelines exist. Design We retrospectively collected data on postoperative infections from 772 septoplasties performed in 2015, 2016 and 2018, and classified the infections according to surgical site infection (SSI) criteria by the Centers for Disease Control and Prevention (CDC). We evaluated the infections according to antibiotic use (preoperative or postoperative, both, or none) and accounted for patient and surgical confounding factors. We compared the results with three previous studies from our department to find out the trend in the occurrence of postoperative infections and in the use of antibiotics. Results Twenty‐nine cases (3.8%) fulfilled CDC infection criteria. Any kind of antibiotic prophylaxis reduced the risk of SSI ( p = .018). One dose of intravenous cefuroxime before incision was the most effective preventive measure ( p = .045). We found no significant effect of postoperative antibiotics. However, postoperative antibiotics lowered the infection rate to 1.8% compared to 6.1% among those not treated with any antibiotics. The only other factor reducing the risk of SSI was local anaesthesia compared with general anaesthesia. Conclusion Preoperative antibiotic prophylaxis effectively reduced postoperative infection rate after septoplasty.
Occult Nipple Involvement in Breast Cancer: Clinicopathologic Findings in 316 Consecutive Mastectomy Specimens

Field: Medicine (Health Sciences)

Purpose Although breast-conserving surgery is a standard approach for patients with breast cancer, mastectomy often becomes necessary. Surgical options now include nipple-sparing mastectomy but its oncological safety is still controversial. This study evaluates frequency and patterns of occult nipple involvement in a large contemporary cohort of patients with the retroareolar margin as possible indicator of nipple involvement. Patients and Methods Three hundred sixteen consecutive mastectomy specimens (232 therapeutic, 84 prophylactic) with grossly unremarkable nipples were evaluated by coronal sections through the entire nipple and subareolar tissue. Extent and location of nipple involvement by carcinoma was assessed with the tissue deep to the skin as potential retroareolar en-face resection margin. Results Seventy-one percent of nipples from therapeutic mastectomies showed no pathologic abnormality, 21% had ductal carcinoma in situ (DCIS), invasive carcinoma (IC), or lymphovascular invasion (LVI), and 8% lobular neoplasia (lobular carcinoma in situ). Human epidermal growth factor receptor 2 amplification, tumor size, and tumor-nipple distance were associated with nipple involvement by multivariate analysis (P = .0047, .0126, and .0176); histologic grade of both DCIS (P = .002) and IC (P = .03), LVI (P = .03), and lymph node involvement (P = .02) by univariate analysis. Nipple involvement by IC or DCIS was identified in the retroareolar margin with a sensitivity of 0.8 and a negative predictive value of 0.96. None of the 84 prophylactic mastectomies showed nipple involvement by IC or DCIS. Conclusion Nipple-sparing mastectomy may be suitable for selected cases of breast carcinoma with low probability of nipple involvement by carcinoma and prophylactic procedures. A retroareolar en-face margin may be used to test for occult involvement in patients undergoing nipple-sparing mastectomy.
PROYEK GEDUNG APARTAMEN THE PAKUBUWONO SPRING

Field: Engineering (Physical Sciences)

ABSTRAK
Kerja Praktik, Jurusan Teknologi SIPIL, Pentingnya tim surveyor pada pekerjaan pembangunan gedung apartemen The Pakubuwono Spring di PT Total Bangun Persada, Tbk. Pembimbing Acep Hidayat, ST, MT
Kerja Praktik merupakan salah satu matakuliah yang harus ditempuh mahasiswa untuk memenuhi persyaratan kelulusan.Selain itu kerja praktik juga diharapkan mampu memberikan ilmu yang bermanfaat bagi para mahasiswa, sehingga mahasiswa mampu memilikii lmu dalam bidang teori dan pengalaman serta menjadikan mahasiswa dapat lebih mandiri sebagai daya saing dalam hal karir nanti nya.
PT Total Bangun Persada,Tbk, merupakan perusahaan konstruksi dengan kemampuan untuk rancang bangun, merancang suatu gedung serta sekaligus membangun gedung tersebut, sehingga menjadikan TOTAL sebagai perusahaan konstruksi dengan kemampuan memberikan jasa konstruksi secara keseluruhan. Kerja praktek dilaksanakan di PT TOTAL pada proyek pembangunan gedung The Pakubuwono Spring yang direncanakan digunakan untuk area hunian Apertemen.
Dalam pekerjaan pembangunan gedung bertingkat biasanya banyak hal yang harus dipersiapkan baik itu alat, material mau pun tenaga kerja dan tenaga kerja ahli. Pada prakteknya metode ini berjalan dengan baik. Namun jika dilihat dari efesiensi waktu dan tenaga jelas membutuhkan waktu serta tingkat ketelitian dan keakuratan yang sangat tinggi dalam pembangunan gedung apartemen.
Penulisan dilakukan dengan metode observasi (pengamatan) dengan mengamati proses pekerjaan yang berlangsung di proyek pembangunan gedung The Pakubuwono Spring, Metode interview (wawancaralangsung) dengan melakukan Tanya jawab secara langsung kepada semua pihak yang terlibat dalam proses pembangunan, Metode pustaka (Literatur) mencari informasi dengan mengumpulkan data dalam proyek pembangunan gedung The Pakubuwono Spring dan Metode instrument dengan mendokumentasikan kegiatan yang berlangsung pada pembangunan gedungThe Pakubuwono Spring. Hasil yang dicapai dari penelitian berdasarkan apa yang dilakukan dalam pekerjaan pembangunan gedung apartemen The Pakubuwono Spring didapat efisiensi biaya waktu dan tenaga serta keakuratan baik itu posisi maupun dimensi sehingga berdampak semakin besar keuntungan yang di dapatdari PT Total Bangun Persada, Tbk.
Kata Kunci : Pentingnya tim surveyor pada pekerjaan pembangunan gedung apartemen The Pakubuwono Spring
Anthelmintic resistance in horse cyathostomins in Europe: current status and future perspectives.

Field: Veterinary (Health Sciences)

Adult and larval stages of cyathostomins (Nematoda, Cyathostominae), known also as small strongyles, cause different degrees of intestinal distresses and diseases in horses. In the past decades, drug resistance in cyathostomins has become widespread, especially for benzimidazoles and tetrahydropirimidines. The recent reports of reduced efficacy in macrocyclic lactones are also of great concern. Given the recent advances into diffusion and distribution of drug resistant populations in different European areas, the present article has the aim to review the current status of the knowledge of anthelmintic resistance in horse cyathostomins in Europe and to discuss perspectives for implementing current control measures.
Integration of PV Distributed Generators into Electrical Networks for Investment and Energy Purchase Costs Reduction by Using a Discrete–Continuous Parallel PSO

Field: Energy (Physical Sciences)

The problem of optimally integrating PV DGs into electrical networks to reduce annual costs (which include energy purchase and investment costs) was addressed in this research by presenting a new solution methodology. For such purpose, we used a Discrete–Continuous Parallel Particle Swarm Optimization method (DCPPSO), which considers both the discrete and continuous variables associated with the location and sizing of DGs in an electrical network and employs a parallel processing tool to reduce processing times. The optimization parameters of the proposed solution methodology were tuned using an external optimization algorithm. To validate the performance of DCPPSO, we employed the 33- and 69-bus test systems and compared it with five other solution methods: the BONMIN solver of the General Algebraic Modeling System (GAMS) and other four discrete–continuous methodologies that have been recently proposed. According to the findings, the DCPPSO produced the best results in terms of quality of the solution, processing time, and repeatability in electrical networks of any size, since it showed a better performance as the size of the electrical system increased.
Charged system search algorithm for robotic drill path optimization

Field: Computer Science (Physical Sciences)

This paper presents a Charged System Search (CSS) algorithm to solve for robotic drill path optimization involved in printed circuit board (PCB) manufacturing industries. Most of the operational time of a PCB Robotic Drill is spent on moving the drill bit between the holes. An optimized path translates to a minimal cost of operating the robot. The drill path consists of a number of potential locations where the holes are going to be drilled. As the number of holes required increases so thus does the complexity to find the optimized path. Recently developed CSS algorithm proposed to solve this complex problem with minimal computational time. The performance of CSS algorithm is tested and verified with four case studies from the literature. The computational experience conducted in this research indicates that the proposed algorithm is capable to efficiently find the optimal path for PCB holes drilling process with reasonable computational time.
[Induction treatment with bortezomib-cyclophosphamide-dexamethasone (CyBorD) for newly diagnosed transplant-eligible patients with multiple myeloma].

Field: Medicine (Health Sciences)

Twenty-nine transplant eligible newly diagnosed multiple myeloma (NDMM) patients have received Cyclophosphamide-Bortezomib-Dexamethasone (CyBorD) as induction treatment in our institute since November 2011. CyBorD is composed of CPA 300 mg/m2 p.o., Bor 1.3 mg/m2 i.v. or s.c., and Dex 40 mg/body p.o. on days 1, 8, 15, and 22. The median number of CyBorD cycles was 4 (range 2-6), except in one patient who progressed during the first cycle. Grade 4 neutropenia was observed in 2 patients, but none experienced grade 2 thrombocytopenia. Grade 3 non-hematologic adverse events were observed in two patients with varicella-zoster virus reactivation. Responses after CyBorD were ≥PR in 72%, ≥VGPR in 52%, ≥CR in 21%, and sCR in 21%. Autologous stem cells were harvested in 27 patients. Seventeen of these 27 patients received high-dose melphalan and autologous stem cell transplantation (ASCT) within 12 months after diagnosis. Patients with ≥CR increased to 59% after ASCT. Our data suggest the efficacy and the feasibility of administering CyBorD to transplant eligible NDMM patients.
‘I hated being ghosted’ – The relevance of social participation for living well with post‐stroke aphasia: Qualitative interviews with working aged adults

Field: Health Professions (Health Sciences)

Abstract Background In the context of increasing incidence of stroke in working aged adults, there is a specific need to explore the views of working aged adults with post‐stroke aphasia, whose communication difficulties may result in restricted social participation, loss of employment and changed relationship and parenting roles. This study aimed to explore the perspectives of working aged adults with post‐stroke aphasia in relation to social participation and living well with aphasia (LWA). Design and participants We conducted qualitative interviews with 14 people with post‐stroke aphasia (PWA). Data were analysed following principles of reflexive, thematic analysis. Patient or Public Contribution: A Public and Patient Involvement aphasia advisory group inputted into the study design and interpretation of data. Results Social participation spanned 5 themes: Relationships and roles; Social support; Peer network, Aphasia awareness; and Employment and training. Meaningful, interesting social participation for LWA is individually defined. Working aged PWA may require flexible support with parenting, accessing a diverse social network and finding opportunities for meaningful social connection, training and employment. Conclusions The findings extend knowledge of social participation in the context of LWA for working aged adults by elucidating the individually defined nature of meaningful participation and how PWA may need flexible support with parenting, accessing a diverse social network and training and employment. For aphasia research, policy and services to be relevant, it is crucial that working aged PWA are meaningfully involved in setting the aphasia agenda.
Evaluation of grain refining performance of aluminum cast using TP-1 test mold

Field: Materials Science (Physical Sciences)

AA-TP1 (Standard Test Procedure for Aluminum Alloy Grain Refiners; TP-1 test) is one of the evaluation tests of aluminum grain refiner. Although it is the most well-maintained test at present, it is not easy to perform the test by academic institutions because it requires a large amount of molten metal. In this study, we propose new evaluation method of grain refining performance of aluminum cast using TP-1 test mold. Effects of temperature of molten metal, holding time after addition of refiner (Al-5%Ti-1%B) and preheating temperature of the mold for microstructure of as-cast pure Al were examined. Obtained results were compared with the microstructure obtained by conventional TP-1 test.
Modeling Shared Situation Awareness

Field: Psychology (Social Sciences)

This study presents an initial computational model of shared situation awareness (SA) based upon data collected from a simulated training exercise, designed to mimic real life events in a military personnel recovery center. Situation awareness was measured during the exercise using the Situation Awareness Global Assessment Technique (SAGAT). Our initial model examined how well five factors (social network distance, physical distance, rank similarity, branch similarity, and experience similarity) predicted shared SA. Overall, regression analyses highlighted the significant influence of geographical distribution (physical distance) on the development of shared SA and frequency of communications amongst team members. The discussion centers on the need for developing useful technological tools and techniques for supporting communication and collaboration among distributed teams.
FACTORS AFFECTING KOREAN OLDER ADULTS’ WILLINGNESS TO RECEIVE LIFE-SUSTAINING TREATMENTS

Field: Health Professions (Health Sciences)

Being one of the fastest aging countries, Korea is faced with various end-of-life (EOL) issues. However, little is known about what affects older adults’ views toward EOL options, such as use of life-sustaining treatments (LSTs). To address the gap, this study aimed to examine the relationship between attitude toward LSTs and background characteristics among older adults in South Korea. Using a national survey data of 10,267 older adults, binomial logistic regression analysis was conducted to examine the likelihood of willingness to receive LSTs with background characteristics. The correlations (.02 ≤ r ≤ .04) and tolerance statistics (≥ .40) were checked during preliminary analysis. Though very few participants (4%) agreed to receive LSTs, some significant relationships were found: those who were female (OR=.24, p=.03) and older (OR = .02, p = .00) and had higher geriatric depression score (OR = .05, p =.02) and more close friends and neighbors to talk openly with (OR= .08, p = .00) were more likely to agree to receive LSTs. However, those having any religion (OR= -.19, p = .03) were less likely to do so. This result suggests that religion in Korean culture may play a role in older adults’ preference for LSTs and may provide a buffering effect against the pursuit of aggressive treatments. Our society should recognize the potential burden of LSTs among Korean older adults and should consider factors, such as gender, age, mental health, and social relationship, in EOL discussion about LSTs and alternative EOL care options.