jimnoneill/paper-to-field-training huggingface dataset:
Bioactive Evaluation of Ursane-Type Pentacyclic Triterpenoids: β-Boswellic Acid Interferes with the Glycosylation and Transport of Intercellular Adhesion Molecule-1 in Human Lung Adenocarcinoma A549 Cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Ursane-type pentacyclic triterpenoids exert various biological effects, including anticancer and anti-inflammatory activities. We previously reported that ursolic acid, corosolic acid, and asiatic acid interfered with the intracellular trafficking and glycosylation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with the pro-inflammatory cytokine interleukin-1α. However, the structure–activity relationship of ursane-type pentacyclic triterpenoids remains unclear. In the present study, the biological activities of seven ursane-type pentacyclic triterpenoids (β-boswellic acid, uvaol, madecassic acid, 3-O-acetyl-11-keto-β-boswellic acid, ursolic acid, corosolic acid, and asiatic acid) were investigated. We revealed that the inhibitory activities of ursane-type pentacyclic triterpenoids on the cell surface expression and glycosylation of ICAM-1 and α-glucosidase activity were influenced by the number of hydroxy groups and/or the presence and position of a carboxyl group. We also showed that β-boswellic acid interfered with ICAM-1 glycosylation in a different manner from other ursane-type pentacyclic triterpenoids.
The Paradox of Capital Theory is the Bohm-Bawerk-Type Economics Logically Inconsistent?

Field: Economics, Econometrics and Finance (Social Sciences)

The prototype of economics as revealed in general in the writings of Walras, Pareto, Wicksell, Hicks (prior to 'Capital and Growth'), Samuelson (of the 'Collected Scientific Papers'), and Joan Robinson (during the golden age of 'The Accumulation of Capital), conceives of the economic system as characterized by the existence of different consumption goods' mixes capable of yielding the same satisfaction flow and of different mixtures of techniques and production processes capable of producing the same bundles of goods. The linear approach postulates the simultaneous use of such diverse mixtures in an actual economic system.
Anti-thromboxane B2 antibodies protect against acetaminophen-induced liver injury in mice

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Prostanoids are lipid compounds that mediate a variety of physiological and pathological functions in almost all body tissues and organs. Thromboxane (TX) A2 is a powerful inducer of platelet aggregation and vasoconstriction and it has ulcerogenic activity in the gastrointestinal tract. Overdose or chronic use of a high dose of acetaminophen (N-acetyl-paminophenol, APAP) is a major cause of acute liver failure in the Western world. We investigated whether TXA2 plays a role in host response to toxic effect of APAP. CBA/H Zg mice of both sexes were intoxicated with a single lethal or high sublethal dose of APAP, which was administered to animals by oral gavage. The toxicity of APAP was determined by observing the survival of mice during 48 h, by measuring concentration of alanine-aminotransferase (ALT) in plasma 20-22 h after APAP administration and by liver histology. The results have shown that anti-thromboxane (TX) B2 antibodies (anti-TXB2) and a selective inhibitor of thromboxane (TX) synthase, benzylimidazole (BZI), were significantly hepatoprotective, while a selective thromboxane receptor (TPR) antagonist, daltroban, was slightly protective in this model of acute liver injury. A stabile metabolite of TXA2, TXB2, and a stabile agonist of TPR, U-46619, had no influence on APAP-induced liver damage. Our findings suggest that TXA2 has a pathogenic role in acute liver toxicity induced with APAP, which was highly abrogated by administration of anti-TXB2. According to our results, this protection is mediated, at least in part, through decreased production of TXB2 by liver fragments<em> ex vivo</em>.
Israel, the Mystic Bride

Field: Arts and Humanities (Social Sciences)

Abstract The impressive poetic structure of the Book of Numbers leads into the deepest level of meanings. The arrangement of the legal studies through the book and their systematic interweaving with major political issues shows that if it is a law book in any sense, it deals with constitutional law. The constitution is for the society of the descendants of Abraham. This suggests a bold interpretive move by which every mention of a law concerning women in Numbers might be taken to refer, not to ‘women’, but to ‘a woman’, Israel. The case of the woman suspected of adultery seems at first to be an incongruous item, wedged between the command to put lepers outside the camp and the laws for the Nazirite. This chapter probes further into why this case is here in the first of the law sections, and suspects that the faithless woman may be Israel.
QoE‐Aware Scheduling Algorithm for Adaptive HTTP Video Delivery in Wireless Networks

Field: Computer Science (Physical Sciences)

In the last years, the video content consumed by mobile users has increased exponentially. Since mobile network capacity cannot be increased as fast as required, it is crucial to develop intelligent schedulers that allocate radio resources very efficiently and are able to provide a high Quality of Experience (QoE) to most of the users. This paper proposes a new and effective scheduling solution—the Maximum Buffer Filling (MBF) algorithm—which aims to increase the number of satisfied users in video streaming services provided by wireless networks. The MBF algorithm uses the current buffer level at the client side and the radio channel conditions, which are reported to the network by the client, as well as the bitrate of the requested video segment. The proposed scheduling strategy can also fulfill different satisfaction criteria, since it can be tuned to maximize the numbers of users with high QoE levels or to minimize the number of users with low QoE levels. A simulation framework was developed, considering a Long Term Evolution (LTE) scenario, in order to assess the performance of the proposed scheduling scheme and to compare it with other well‐known scheduling solutions. The results show the superior performance achieved by the proposed technique, in terms of the number of satisfied and unsatisfied users.
Inductive edge sensors: an innovative solution for ELT segmented mirror alignment monitoring

Field: Engineering (Physical Sciences)

The largest telescopes (ELT) involve a highly segmented primary mirror. The monitoring of the mirror shape use thousands of sensors, located on segment edges, which measure the relative piston, tip and tilt of all segments. Today, telescopes with segmented primary mirrors use capacitance-based edge sensors. Although this technology offers excellent metrological performances, its practical use is limited by the intrinsic sensitivity to humidity, dust and condensation, whose effect exceeds the requirements for future ELTs. Being specialized in both capacitive and inductive metrology, Fogale nanotech has developed a novel concept of edge sensors using the inductive technology, which does not suffer from humidity, condensation, and dust effects. Cost effective sensor with specific layout, associated electronics, demonstrated metrological performance (sub-nanometer resolution and nanometer stability) that outperforms the capacitive concept.
The Impact of Gender Inequality in Education and Employment on Economic Growth: New Evidence for a Panel of Countries

Field: Economics, Econometrics and Finance (Social Sciences)

Using cross-country and panel regressions, we investigate to what extent gender gaps in education and employment (proxied using gender gaps in labor force participation) reduce economic growth. Using the most recent data and investigating an extended time period (1960-2000), we update the results of previous studies on education gaps on growth and extend the analysis to employment gaps using panel data. We find that gender gaps in education and employment considerably reduce economic growth. The combined “costs” of education and employment gaps in the Middle East and North Africa, and South Asia amount respectively to 0.9-1.7 and 0.1-1.6 percentage point differences in growth compared to East Asia. Gender gaps in employment appear to have an increasing effect on economic growth differences between regions, with the Middle East and North Africa, and South Asia suffering from slower growth in female employment.
Power allocation policy and performance analysis of secure and reliable communication in cognitive radio networks

Field: Computer Science (Physical Sciences)

This paper investigates the problem of secure and reliable communications for cognitive radio networks. More specifically, we consider a single input multiple output cognitive model where the secondary user (SU) faces an eavesdropping attack while being subject to the normal interference constraint imposed by the primary user (PU). Thus, the SU must have a suitable power allocation policy which does not only satisfy the constraints of the PU but also the security constraints such that it obtains a reasonable performance for the SU, without exposing information to the eavesdropper. We derive four power allocation policies for different scenarios corresponding to whether or not the channel state information of the PU and the eavesdropper are available at the SU. Further, we introduce the concept secure and reliable communication probability (SRCP) as a performance metric to evaluate the considered system, as well as the efficiency of the four power allocation policies. Finally, we present numerical examples to illustrate the power allocation polices, and the impact of these policies on the SRCP of the SU.
Diagnostic et gestion d'un cas particulier de constipation opiniâtre

Field: Medicine (Health Sciences)

Constipation is a very common pattern in childhood. There are multiple reasons for constipation including one very rare :chronic intestinal pseudo-obstruction syndrome. We report the case of a young patient monitored for multiple incidents of intestinal pseudo- obstruction with intractable constipation. The patient underwent several surgical interventions to relieve his symptoms because the non operative treatments, based on liquid diet and laxatives, didn't show great effectiveness. We will review the differential diagnosis of chronic constipation and we will discuss the particular diagnostic entity of this patient. We will also discuss the different treatments that allowed to provide tolerance to oral feeding.
Immunomodulatory effect of bovine lactoferrin during SARS-CoV-2 infection

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Lactoferrin (Lf) is an important immunomodulator in infectionsus caused by different agents. During SARS-CoV-2 infection, Lf can hinder or prevent virus access to the intracellular environment. Severe cases of COVID-19 are related to increased production of cytokines, accompanied by a weak type 1 interferon response. We investigated the influence of bovine lactoferrin (bLf) in the immune response during SARS-CoV-2 infection in vitro, and in vivo assays. Our results show a strong binding between bLf and TLR4/NF-kB in silico, as well as an increase in mRNA expression on of these genes in peripheral blood mononuclear cells (PBMC) treated with bLf. Furthermore, the treatment increased TLR4/TLR9 mRNA expression in infected K18-hACE2 mice blood, indicating an activation of innate response. Our results show that when bLf was added, a reduction in the NK cell population was found, presenting a similar effect on PD-1 in TCD4+ and TCD8+ cells. In the culture supernatant of PBMC from healthy participants, bLf decreased IL-6 levels and increased CCL5 in COVID-19 participants. In addition, k18-hACE2 mice infected and treated with bLf presented an increase of serum pro-inflammatory markers (GM-CSF/IL-1b/IL-2), and upregulated mRNA expression of IL1B and IL6 in the lung tissue. Furthermore, bLf treatment was able to restore FTH1 levels in brain tissue. The data indicates that bLf can be part of a therapeutic strategy to promote the immunomodulation effect, leading to homeostasis during COVID-19.
Reliability of B-mode ultrasonic measurements of subcutaneous adipose tissue and intra-abdominal depth: comparisons with skinfold thicknesses.

Field: Health Professions (Health Sciences)

Adipose tissue deposits, particularly intra-abdominal adipose tissue, are associated with health risks such as diabetes mellitus and cardiovascular disease. Anthropometric techniques currently in use can measure subcutaneous adipose tissue (SAT) with skinfold calipers, but are limited to certain sites and cannot measure intra-abdominal adipose tissue (IAAT). Radiography, computerized tomography (CT) and magnetic resonance imaging (MRI) have been used, but they are expensive and some involve exposure to radiation. This study, which investigated the utility of B-mode ultrasound for measuring adipose tissue, found that ultrasonic measurements of SAT were as reliable as skinfold caliper measurements. Intra-observer and inter-observer coefficients of reliability for five of six ultrasonic measurements of SAT ranged from 91-98%, in comparison with coefficients of reliability ranging from 93-98% for three skinfold measurements. Coefficients of reliability for ultrasonic measurements of SAT at the paraspinal site were below 90%. Ultrasonic measurements of intra-abdominal depth (IAD), an index of IAAT, yielded an inter-observer coefficient of reliability of 64%. Ultrasound is recommended for measurement of subcutaneous adipose tissue but not for measurement of IAD.
Electrical properties of microporous rock as a function of saturation and temperature

Field: Earth and Planetary Sciences (Physical Sciences)

We measured the electrical resistivity of densely welded tuff (Topopah Spring tuff) as a function of saturation by water between 23 and 145 °C. Measurements at 23–95 °C were performed at ambient pressure and measurements up to 145 °C were performed at pressures up to 5.5 MPa in an externally heated pressure vessel. Pore and confining pressures were controlled independently, allowing electrical measurements as the sample was subjected to boiling conditions. Resistivity changes associated with liquid water flashing to steam were observed. Incremental increases in resistivity with decreasing pore pressure are attributed to vapor pressure lowering caused by capillary tension in the nanometer-size pores. This result has important implications for models of reservoir engineering, geologic nuclear-waste disposal, and geophysical sensing techniques.
Tryptophan Repressor-Binding Proteins from Escherichia coli and Archaeoglobus fulgidus as New Catalysts for 1,4-Dihydronicotinamide Adenine Dinucleotide-Dependent Amperometric Biosensors and Biofuel Cells

Field: Chemistry (Physical Sciences)

The tryptophan (W) repressor-binding proteins (WrbA) from Escherichia coli (EcWrbA) and Archaeoglobus fulgidus (AfWrbA) were investigated for possible use in 1,4-dihydronicotinamide adenine dinucleotide (NADH) dependent amperometric biosensors and biofuel cells. EcWrbA and AfWrbA are oligomeric flavoproteins binding one flavin mononucleotide (FMN) per monomer and belonging to a new family of NAD(P)H:quinone oxidoreductases (NQOs). The enzymes were covalently linked to a low potential Os redox polymer onto graphite in the presence of single-walled carbon nanotube (SWCNT) preparations of varying average lengths. The performance of the enzyme modified electrodes for NADH oxidation was strongly depending on the average length of the applied SWCNTs. By blending the Os redox polymer with SWCNTs, the electrocatalytic current could be increased up to a factor of 5. Results obtained for AfWrbA modified electrodes were better than those for EcWrbA. For NADH detection, a linear range between 5 microM and 1 mM, a lower limit of detection of 3 microM, and a sensitivity of 56.5 nA microM(-1) cm(-2) could be reached. Additionally spectroelectrochemical measurements were carried out in order to determine the midpoint potentials of the enzymes (-115 mV vs NHE for EcWrbA and -100 mV vs NHE for AfWrbA pH 7.0). Furthermore, an AfWrbA modified electrode was used as an anode in combination with a Pt black cathode as a biofuel cell prototype.
Brief information related to potential therapeutic tendencies of citrus plants

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Citrus plants play an important role as a health-protector. They are containing various phytochemical that reduce or prevent risk for various diseases such as cancer, heart disease and aging effects. Citrus are good sources of naturally occurring antioxidants like vitamin C, vitamin E, carotenes, phenolic acids, phytate and phytoestrogens that have been recognized potentially to reduce various disease risks. Some compounds, have strong antioxidant activity, while others, such as the mono-phenols are weak antioxidants. Antioxidant compounds scavenge free radicals and thus inhibit the oxidative mechanisms that lead to degenerative diseases. The free radicals may oxidize nucleic acids, proteins, lipids or DNA and can initiate degenerative disease. There are a number of studies suggesting that the antioxidants are the main factors for reducing the incidence of chronic diseases including heart disease and some cancers. Keywords: Citrus, Antioxidants, Vitamins, Degenerative Diseases.
[Hormonal regulation of anabolic processes and of protein utilization efficiency in the early postnatal period].

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The levels of thyroid, pituitary and steroid hormones-thyroxine, triiodothyronine and 11-hydroxycorticosteroids in the blood serum, somatotropin in the pituitary, and processes of protein assimilation were studied in rats in the early postnatal period. The highest endogenous production of thyroxine, triiodothyronine and somatotropin was detected in 15-day-old rats. The highest level of protein utilization was detected in 7 to 15-day-old rats, followed by the lowering of the utilization on changing over to definitive nutrition. Endogenous production of the anabolic hormones thyroxine, triiodothyronine and somatotropin was found to correlate with a high level of protein utilization in rats within the first days of life after birth.
Energy Consumption Predication in China Based on the Modified Fractional Grey Prediction Model

Field: Energy (Physical Sciences)

China’s increasing energy consumption poses challenges to economy and environment. How to predict the energy consumption accurately and regulate the future energy consumption production is a problem worth studying. In this paper, the fractional order cumulative linear time-varying parameter discrete grey prediction model (FTDGM (1, 1) model) is introduced. Firstly, the data are preprocessed by buffer operators, and then, the FTDGM (1, 1) model is established. In this paper, the parameter estimation method and the specific process of model establishment are presented. Finally, the models of energy consumption in China are built. The advantages and prediction accuracy of the model established in this paper are analyzed, and the data in the following years are effectively predicted, so as to provide theoretical support for the government to formulate reasonable energy policies.
Sektoravgiftsordningen for kulturminneundersøkelser i regulerte vassdrag

Field: Social Sciences (Social Sciences)

\nThe arrangement with sector fee for heritage management in regulated watercourses. \n \n\nIn this report I account for the background, legislation, and procedures of the arrangement of sector fee within the hydroelectric sector in Norway. I discuss preliminary experiences with the arrangement, look at the practical and principal challenges with archaeological investigations in submerged areas, and possibilities for future projects. \n
A Practical Model for Ethical Decision Making in Issues Management and Public Relations

Field: Social Sciences (Social Sciences)

The deontological philosophy of Immanuel Kant (1724–1804) provides a powerful framework for the analysis of ethical dilemmas. Kant's philosophy is discussed and applied to what this research poses as the "practical model for ethical decision making" (see Figure 1). This Kantian model establishes an ethical consideration triangle and incorporates symmetrical communication. The issues management of 2 global organizations was used as an empirical test of the model and to refine it for practical implementation. I argue that rigorous analysis of ethical decisions and symmetrical communication result in ethical issues management.
Cardiovascular Complications Associated with COVID-19 Infection

Field: Medicine (Health Sciences)

COVID-19 has spread worldwide and caused pneumonia-like illness similar to that caused by SARS-CoV and MERS-CoV. Apart from lung injury, coronaviruses cause severe cardiovascular disorders. Studies have confirmed that COVID-19 uses angiotensin-converting enzyme 2 (ACE2) receptor to enter the host cell similar to SARS-CoV. ACE2 receptors are found in various body organs including lungs, heart in kidneys. The most common complication observed are acute respiratory distress syndrome, acute cardiac injury and cardiovascular disorders including myocarditis, cardiac arrythmias and myocardial infarction. It can also cause acute and chronic cardiovascular diseases. Almost 20% of patients progress to severe condition. Patients with underlying cardiovascular disorders have poor prognosis. It is believed that ACEI/ARBS can alleviate the cardiovascular problems in COVID-19 patients. Hence, the risk factors for cardiovascular disease and complications should be carefully considered.
The Formulation Preparation of Tebufenozide·Emamectin Benzoate 20% SC

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The formulation of tebufenozide·emamectin benzoate 20% sc was developed with the method of wet milling,according to the standard of suspension rate(≥90%),screen analysis,dispersity,heat storage stability[(54±2) °c,14 d].The formulation was optimized with main adjuvants such as wetting-dispersing agent,anti-freeze agent,thicking agent and etc.The receipt was composed of tebufenozide(19%),emamectin benzoate(1%),dispersing agent(1.9%),emulsifier(5%),thicking agent(0.1%),antifreeze agent(5%),defoamer(0.2%).It was founded that its physical and chemical properties were not changed significantly after the formulation was stored under cold and thawing conditions respectively and that the suspension rate was over 90%.
Historical evolution and mathematical models: A sociocultural algorithm

Field: Social Sciences (Social Sciences)

Though there are a lot of approaches to the problem of sociocultural evolution most of them are only one-sided, i.e., they deal only with either social or cultural processes. With few exceptions they are also only informal theories with no formal rigour. In this article we propose a theoretical model which considers both sides of the problem, that is the mutual interdependence of the evolution of social structures and of the culture of a society. A mathematical model, the sociocultural algorithm (SCA), based on these theoretical considerations maps several of the dynamic characteristics of sociocultural evolution, suggesting that universal principles underlie the dynamics of historical evolution.