jimnoneill/paper-to-field-training huggingface dataset:
A Versatile Skin-Derived Extracellular Matrix Hydrogel-Based Platform to Investigate the Function of a Mechanically Isolated Adipose Tissue Stromal Vascular Fraction

Field: Medicine (Health Sciences)

Introduction: To accelerate cutaneous wound healing and prevent scarring, regenerative approaches such as injecting a mechanically derived tissue stromal vascular fraction (tSVF) are currently under clinical and laboratory investigations. The aim of our study was to investigate a platform to assess the interaction between skin-derived extracellular matrix (ECM) hydrogels and tSVF and their effects on their microenvironment in the first ten days of culture. Material and Methods: A tSVF mixed with ECM hydrogel was cultured for ten days. After 0, 3, 5, and 10 days of culture viability, histology, immunohistochemistry, gene expression, and collagen alignment and organization were assessed. Results: The viability analysis showed that tSVF remained viable during 10 days of culture and seemed to remain within their constitutive ECM. The fiber analysis demonstrated that collagen alignment and organization were not altered. No outgrowth of capillaries was observed in (immuno)histochemical staining. The gene expression analysis revealed that paracrine factors TGFB1 and VEGFA did not change and yet were constitutively expressed. Pro-inflammatory factors IL1B and IL6 were downregulated. Matrix remodeling gene MMP1 was upregulated from day three on, while MMP14 was upregulated at day three and ten. Interestingly, MMP14 was downregulated at day five compared to day three while MMP2 was downregulated after day zero. Conclusions: Skin-derived ECM hydrogels appear to be a versatile platform for investigating the function of a mechanically isolated adipose tissue stromal vascular fraction. In vitro tSVF remained viable for 10 days and sustained the expression of pro-regenerative factors, but is in need of additional triggers to induce vascularization or show signs of remodeling of the surrounding ECM. In the future, ECM-encapsulated tSVF may show promise for clinical administration to improve wound healing.
Feasibility and Effectiveness of the GLB-AIM (Group Lifestyle Balance Adapted for Individuals With Impaired Mobility) Intervention for People Living with Spinal Cord Injury

Field: Health Professions (Health Sciences)

Purpose: The prevalence of obesity in the population living with spinal cord injury (SCI) is greater than the general population. Obesity linked coronary heart disease is a leading cause of morbidity and mortality in the population living with SCI. Behavioral interventions to promote weight loss are limited for the SCI population. GLB-AIM looks to address the lack of behavioral interventions by providing a feasible and effective program to promote weight loss for people living with SCI. Methods: The GLB-AIM was delivered to participants over the course of 12 months. The sample was assessed for feasibility as measured by attendance over 12-month program and compliance with dietary self-monitoring for the first 13 weeks. Effectiveness was evaluated by measuring weight change over 12 months. The data were analyzed using a mixed models analysis controlling for time living with injury, group assignment, and starting weight. Results: The 12-month retention rate was 62.5% (20/32), Session attendance for the core sessions averaged 74.6% and dropped to 48.9% during the support sessions. Dietary self-monitoring for group 1 averaged 33% over the first 13 sessions and increased to 77% among group 2. Analysis of the combined SCI groups indicated significant weight loss (p = 0.017) that averaged 5.03 +8.58 kg over the 12-month program. Discussion: The GLB-AIM was a feasible and effective approach for promoting weight loss over 12 months for a sample with SCI. Additional adaptations may increase attendance during the subsequent support sessions and reduce program attrition by addressing barriers related to health events and transportation issues. The GLB-AIM program promoted weight loss in people living with SCI, which highlights the program’s effectiveness. Future adaptations of the GLBAIM should seek to enhance weight loss through increased weight feedback and the providing individualized calorie targets.
Visual Interventions

Field: Social Sciences (Social Sciences)

Visual anthropology has proved to offer fruitful methods of research and representation to applied projects of social intervention. Through a series of case studies based on applied visual anthropological work in a range of contexts (health and medicine, tourism and heritage, social development, conflict and disaster relief, community filmmaking and empowerment, and industry) this volume examines both the range contexts in which applied visual anthropology is engaged, and the methodological and theoretical issues it raises.
The Role of TOP2A Protein Expression and Aneuploidy in NSCLC

Field: Medicine (Health Sciences)

Abstract

Purpose DNA topoisomerase II alpha (TOP2A) is a cell-cycle dependent protein associated with cell proliferation and division. Abnormal regulation of TOP2A and aneuploidy induces tumorigenesis and poor prognosis. Data related to TOP2A protein in non-small cell lung cancer (NSCLC) is limited to few studies on gene status. The present study aimed to investigate the consistency between aneuploidy and expression of TOP2A gene and protein, respectively, and the role of aneuploidy in the prognosis of NSCLC patients. Methods Clinical data and lung cancer tissues were collected from 244 patients with NSCLC. TOP2A protein and gene expression were detected using immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), respectively. Nonparametric Spearman’s rank sum test was used to analyze clinicopathological data. Kaplan–Meier and multivariate Cox regression methods were used for survival analysis. Results Enhanced expression and amplification rate of TOP2A protein and gene were 29.9% (73/244) and 0.4% (1/244), respectively. The aneuploidy rate was 31.6% (77/244). In NSCLC, patients with enhanced expression of TOP2A protein and aneuploidy correlated with clinical stages (p < 0.001) Enhanced expression of TOP2A protein was consistent with aneuploidy as detected by Kappa test (K = 0.307) and this correlation was confirmed by chi-square test (p < 0.001). The overall survival of patients with aneuploidy was shorter than diploidy (p < 0.001). Clinically advanced patients with aneuploidy together with TOP2A overexpression had poor prognosis (p < 0.001). Conclusion Aneuploidy and overexpression of TOP2A is a predictor of poor prognosis in patients with advanced NSCLC.
Soil Temperatures, Weather Conditions, and Emergence of Ground Squirrels from Hibernation

Field: Agricultural and Biological Sciences (Life Sciences)

Journal Article Soil Temperatures, Weather Conditions, and Emergence of Ground Squirrels from Hibernation Get access Otis Wade Otis Wade Studies from the Department of Zoology, University of Nebraska, No. 244 Search for other works by this author on: Oxford Academic Google Scholar Journal of Mammalogy, Volume 31, Issue 2, May 1950, Pages 158–161, https://doi.org/10.2307/1375509 Published: 01 May 1950 Article history Received: 27 June 1949 Published: 01 May 1950
Hospital pharmacy management problems and countermeasures

Field: Health Professions (Health Sciences)

Pharmacy plays an important role in medicine management of hospital, but the present hospital pharmacy generally exist some problems, such as nonstandard system, unscientific management, low overall quality pharmaceutical service personnel, etc., which seriously affect the foreign image of the hospital, and have harmful effects on the medication safety of the hospital. Establishing relevant system, strengthening management are the main measures to improve the current situation of the pharmacy, and it has great significance in improving the drug management and hospital management level.
Principles and Applications of Dual-Layer Spectral CT in Gastrointestinal Imaging

Field: Medicine (Health Sciences)

The advance in technology allows for the development of different CT scanners in the field of dual-energy computed tomography (DECT). In particular, a recently developed detector-based technology can collect data from different energy levels, thanks to its layers. The use of this system is suited for material decomposition with perfect spatial and temporal registration. Thanks to post-processing techniques, these scanners can generate conventional, material decomposition (including virtual non-contrast (VNC), iodine maps, Z-effective imaging, and uric acid pair images) and virtual monoenergetic images (VMIs). In recent years, different studies have been published regarding the use of DECT in clinical practice. On these bases, considering that different papers have been published using the DECT technology, a review regarding its clinical application can be useful. We focused on the usefulness of DECT technology in gastrointestinal imaging, where DECT plays an important role.
Clofarabine administered weekly to adult patients with advanced solid tumors in a phase I dose-finding study

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

3115 Background: Clofarabine, a next-generation nucleoside analogue that inhibits DNA synthesis, has demonstrated activity in acute leukemia in Phase I and II trials. The agent has also shown potent cytotoxic activity in a wide range of solid tumor cell lines and therapeutic activity in murine tumor models. Methods: A Phase I dose-finding study is ongoing to determine the maximum tolerated dose (MTD) of clofarabine in patients with advanced solid tumors. To avoid the dose limiting toxicity of myelosuppression observed with the daily × 5 administration used for hematologic malignancies, clofarabine is administered IV on days 1, 8, and 15 of a 28-day cycle. Cohorts of patients are treated with escalating doses beginning with clofarabine 4 mg/m2 until MTD is determined. Results: Thirty patients have been treated in 8 cohorts; 3 each at 4, 6, 10, 14, 18, and 27.5 mg/m2, and 6 each at 22 and 34 mg/m2. MTD has not been reached and enrollment is continuing. Preliminary data are available for 21 patients who have completed at least 1 cycle of treatment in the first 6 cohorts (up to 22 mg/m2), 12 males and 9 females with a median age of 65 years (range 48 to 78). Tumor types include colorectal (5); non-small cell lung (3); squamous cell larynx, transitional cell bladder, and prostate (2 each); and adenosquamous gallbladder, bronchioalveolar, hepatocellular/cholangiocarcinoma, leiomysarcoma, melanoma, pancreas, and squamous cell esophagus (1 each). Six patients completed ≥3 cycles of treatment with 4 patients completing 4 cycles. Data on 20 of the 21 patients show that 7 had stable disease (SD) as their best response; 1 prostate cancer patient had a drop in PSA level from 7975 ng/mL at baseline to 934 ng/mL at end of study. Major toxicities include myelosuppression, nausea, vomiting, and fatigue. Conclusions: Clofarabine has been administered weekly for 3 weeks (days 1, 8, and 15) every 28 days to adult patients with solid tumors; no dose limiting toxicity has been observed, and the MTD has not been reached. Enrollment is ongoing in the 42.5 mg/m2 cohort. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration ILEX Oncology, Inc., ILEX Products, Inc. an affiliate of ILEX Oncology ILEX Oncology, Inc., ILEX Products, Inc. an affiliate of ILEX Oncology ILEX Oncology, Inc.
Tables and figures complementing the European Union One Health 2019 Zoonoses Report

Field: Health Professions (Health Sciences)

All summary tables and figures produced for the European Union One Health 2019 Zoonoses Report are provided as archives containing Excel files for tables, and as PDF or PNG files for figures. All country data connected to this Report are published SEPARATELY on Knowledge Junction - see related identifiers. This is because DATA OWNERSHIP for country data stays with the organisation(s) of the country submitting the data - for further reference see doi:10.2903/sp.efsa.2019.EN-1544.
TYA Festivals: 2/Keeping One Step Ahead

Field: Arts and Humanities (Social Sciences)

Recognition of the legitimate place of theatre for young people has been a long time coming in Canada. But now that it has at last gained some sense of respect, it is far more progressive than its big brothers in the U.S.A. and the U.S.S.R. Both superpowers have a long tradition of children’s theatre. Unfortunately, that tradition has shackled them to stereotypes, tradition and the need for spectacle. In Canada there has been a healthy development of dramatic literature and presentation for children and young people that explores social issues and group dynamics. The growth of drama in the education system, over the past 15 years in particular, has played a major role in this evolution. Canadian teachers have adopted the British drama-ineducation approach, rather than the American show-and-tell system, and have developed a uniquely Canadian educational drama. We have paid close attention to Canadian sources, both historical and literary, for our drama. And consequently our young audiences have become eager and ready to participate in the theatre experience in a very special fashion.
Complications in Chronic Pancreatitis

Field: Medicine (Health Sciences)

Recent advances in molecular and cellular biology have generated a better understanding of chronic pancreatitis. This disease is characterised histologically by a progressive inflammatory disease with irreversible pathological changes leading to insufficient secretion from both the exocrine and endocrine pancreas. The most common complications in chronic pancreatitis are intractable pain and the development of complicated pseudocysts. The present review will deal with these complications as well as bleeding, pancreatic ascites and pleural effusions, jaundice, and intestinal obstruction. Each complication will be described in detail with their pathogenesis and their medical, interventional and surgical treatment options.
Want to Stick to Your Goals? Think About “Dissimilar” Alternatives That You’Ve Forgone!

Field: Psychology (Social Sciences)

Past research demonstrates that thinking about forgone alternatives influences utility from a chosen option. Consumers obtain higher utility when choosing a virtue from a mixed set that contains both vices and virtues than choosing from a homogeneous set that only contains virtuous options (Dhar & Wertenbroch, 2012). Further, Sagi and Friedland (2007) suggest that when choosing from diverse alternatives, evaluations of a chosen option depend on the summed utility of all of the unchosen alternatives, not just the second-best alternative’s utility.
ANALYSIS OF THE FORM AND EVOLUTION OF THE SOLID PHASE DURING DIRECTIONAL CRYSTALLIZATION OF NON-FERROUS METALS WITH ELECTROMAGNETIC INFLUENCE BY ULTRASONIC AND TEMPERATURE METHODS

Field: Engineering (Physical Sciences)

The paper is devoted to the experimental study of new mechanisms of controlling the process of directional crystallization of non-ferrous metals. The focus of the study is on the development and testing of measuring techniques applicable both to laboratory modeling and to processes under real operating conditions. The mechanism of controlling the rate and homogeneity of crystallization of a metal melt by changing the phase angles between the supply currents of a traveling magnetic field induction stirrer is proposed. This makes it possible to generate vortex flows of various topologies in the liquid metal, in particular, to change the number of large-scale vortices or to suppress the large-scale flow. It is shown that the hydrodynamic flows have an impact on the crystallization front shape, which allows one to control the homogeneity of metal solidification by changing the characteristics of the power supply of the inductor. It is important to note that a change in the phase angles of the currents while maintaining the supply amplitude does not significantly affect the crystallization rate, which opens up wide possibilities for controlling processes by changing both the current strength and the phase angles. The temperature method for determining the position of the crystallization front was successfully applied and verified by ultrasonic velocimetry measurements. It has been found that, in the presence of developed flows in a liquid medium, thermocouple measurements provide good agreement (up to a few percent) of the measured position and geometric shape of the crystallization front with the ultrasonic measurement data. In the absence of liquid phase stirring, the difference between the thermocouple and ultrasonic measurements increases slightly. Nevertheless, even in this case, the thermocouple method can be used to correctly determine the position and velocity of the crystallization front.
Mindninja: Concept, Development and Evaluation of a Mind Action Game Based on EEGs

Field: Computer Science (Physical Sciences)

Nowadays, Brain Computer Interface (BCI) are becoming accessible and cheap solutions and can be acquired with nonintrusive top off-the-shelf products. This creates a new paradigm of interaction for games. This work presents a novel architecture and framework that can help the development of games with both BCI and traditional interfaces. As a proof of concept, this paper shows the experience in designing and developing a game prototype using the framework and EEG brainwaves as one of the players input. The game is an action slice game, similar to Fruit Ninja, called MindNinja. This game differ form most BCI game, since it is based on a action game, where the BCI is used as an auxiliary input. This game was tested and evaluated with a group of person, showing promising results in the fun level, as well as increasing the attention level of subjects.
THE POSSIBILITIES OF COUNTERACTING ALCOHOL INEBRIATION

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Various attempts to counteract acute etoh effects have not been rewarding so far. Various reports from animal experiments suggest that etoh sleep or etoh anaesthesia is effectively counteracted with various more or less non-specific stimulants, but these results refer to heavy etoh intoxication only. An altered turn-over of various brain neurotransmitters, well documented in animals, may not be an important contributor to inebriation but is rather associated with etoh inebriation in a non-specific way. One may conclude that there is no relevant animal behaviour model that matches the subtle central depression after low doses of etoh. Etoh acts as a solvent which impairs various membrane functions, and a really effective specific antagonist would be hard to find. (Author/TRRL)
Metricsofthegynecologiconcologyliteraturefocusedoncitedutilization and costs

Field: Medicine (Health Sciences)

article i nfo Objective. The newest findings on literature utilization relevant to gynecologic oncology were published by Thomson Reuters during June2013 asdeterminants of journal standing. Our objective was to assess thedifferent metrics reported for relative impact and cost for journals relevant to gynecologic oncology. Methods. 55 journals were evaluated for Impact Factor (IF), 5 Year IF, Immediacy Index, Cited Half Life, Eigenfactor (EF) Score, Article Influence (AI) scores and subscription costs obtained from publisher information. Results. CA-A Cancer Journal for Clinicianshad the highest IF (101.78) & AI (24.502). The top EF cancer-specific journals were theJournalofClinicalOncology,CancerResearch,ClinicalCancerResearchandOncogene.Rankingsfor Gynecologic Oncology (409articles,18,243citations)were IF = 3.929,43/55,EF = 0.038,28/55,andAI = 1.099, 44/55, all higher than the previous year. The IF improved from the 5 year IF in 31 journals, including Gynecologic Oncology, 29/31. Subscription costs for Gynecologic Oncology compared favorably to other journals. Conclusions. The high utilization of review information inCA-A Cancer Journal for Cliniciansand Nature Review Cancer illustrated by the IF coupled with a relatively low number of articles and short cited half life indicates that they serve as a leading source of quoted cancer statistics (CA-A Cancer Journal for Clinicians). Rankings for Gynecologic Oncology and the International Journal of Gynecologic Cancer have improved. Regardless of specialty size, the Impact Factor for Gynecologic Oncology is respectably strong. The decreased IF in 44% of the journals may reflect the international economy's effect on cancer research.
On the double-vacuum phenomenon of a supersonic air ejector.

Field: Engineering (Physical Sciences)

混合部にスロートを有する超音速空気エゼクタの作動特性線図に現われる履歴現象,すなわち二重真空現象を実験的に調べた.その結果,この現象は,二次流量の増減によるエゼクタスロートにおける流れのチョーキングおよびその解消と,それに伴うエゼクタ内の衝撃波の挙動で説明されることが明らかになった.また定常一次元流れの過程により,二重真空現象が起こる場合の衝撃波の挙動を解析し,実験結果と定性的に一致する結果を得た.
Breaking with Conservatism?

Field: Social Sciences (Social Sciences)

The Japanese Supreme Court has been described as “the most conservative constitutional court in the world”. And, though lower courts can sometimes be more active, the Japanese judiciary as a whole tends also to be referred to as conservative. However, recent developments challenge this view. In particular, Japanese courts have begun to issue rulings in favour of the rights of sexual and gender minorities on issues like same-sex marriage and gender recognition. Do these decisions suggest that the conservatism of the Japanese judiciary has been overstated – or are they signs of change?
Numerical study of ion energy and angular distributions in dual-frequency capacitively coupled CF4 plasmas

Field: Physics and Astronomy (Physical Sciences)

A one-dimensional hybrid model is presented in the paper to study the characteristics of ion energy and angular distributions on the rf-biased electrode in dual frequency capacitively coupled CF4 discharges. The hybrid model includes two parts: a fluid module and a Monte Carlo (MC) module. The fluid module determines the spatiotemporal evolutions of bulk plasma, and the MC module describes the ion-neutral collisions to predict the ion energy and angular distributions on rf-biased electrode. The discussion of this paper focuses on the influence of pressure, voltage, amplitude, and frequencies of the low frequency source on ion energy distributions (IEDs) and ion angular distributions (IADs) of CF3+ and F+ ions. For the CF3+ ions, the IEDs appear to have multiple-peak structures in the dual frequency capacitively coupled rf discharge, and the IADs have a significant peak at a small angle. With the increase of pressure, the maximum energy in IEDs decreases, and the IADs spread to a large angle region. With the decrease of the low frequency or increase of the LF voltage, more ions get a higher energy while they are going across the sheath region, the width and maximum ion energy of IEDs increase, and the peaks in IADs shift toward small angle regions. For the F+ ions, the IEDs are modulated strongly by the sheath field, and the peaks are more prominent than those of heavy ions. The width between different peaks is narrower than that of CF3+ ions, and the maximum energy is also higher.