jimnoneill/paper-to-field-training huggingface dataset:
The efficacy of chemo-mechanical removal of dentin carious lesion

Field: Dentistry (Health Sciences)

Mechanical removals in decayed teeth have been performed using drill and sharp hand instruments. These methods have some disadvantages such as pain, local anesthesia and overextended cavities Therefore chemo-mechanical excavation of dentin carious lesions has been introduced. The purpose of this study was to evaluate the efficacy of traditional mechanical methods using burs and chemo-mechanical methods (Carisolv) of caries dentin. Mechanical caries removal was carried with low speed round bur Chemo-mechanical caries excavation was performed with Carisolv (Medi-team), using the Carisolv hand instruments. The mean time to remove caries with two different methods was evaluated and the data analyzed with SPSS software (ver 11.5) by t-test (p 23 sharp explorers, Caries Detector (Kuraray Co. Japan), and standard apical radiography. 1. Chemo-mechanical method was taken more times than mechanical method (1.5 fold) (p 0.05). 4. The remaining carious dentin was detected after the ckemo-mechanical removal of the carious dentin, and no smear layer were seen after the mechanical and chemo-mechanical removal of the carious dentin.
THE ABCS OF VEGETATION CONTROL

Field: Engineering (Physical Sciences)

Railroads implement vegetation removal programs on their properties for the following reasons: to improve or maintain working conditions; remove health and safety hazards; conform with federal, state and local laws, maintain the integrity of the railroad infrastructure; reduce the source of weed seeds to adjacent fields; prevent overgrowth of weeds in urban and suburban areas; and improve the appearance of the railroad. This article provides some basic information railroaders need to know about vegetation control, such as programs, safety and equipment.
Earthcomm-based Electronic Module: The Learning Material of Natural Resource Management Wisdom

Field: Social Sciences (Social Sciences)

The study aims to identify: 1) The need of Earthcomm-based electronic module in the learning material of wisdom in natural resource management, 2) The stages of Earthcommbased electronic module development, and 3) The feasibility of Earthcomm-based electronic module in the learning material of wisdom in natural resource management. This study is a Research and Development (R&D) research with ADDIE (Analysis, Design, Development, Implementation, and Evaluation). Conclusions of the study are that: 1) the students need the Earthcomm-based electronic module, 2) the Earthcomm-based electronic module is adapted with curriculum 2013 and developed by using Flipbook maker application and is packaged in the form of compact disk (CD), 3) the feasibility of Earthcomm-based electronic module according to the experts' team consisting of media experts, material experts and linguists is 84% and according to the students' response is 84%, therefore, it can be said that it is worth to be used.
Tuning of multivariable PI/PID controllers for TITO processes using dominant pole placement approach

Field: Engineering (Physical Sciences)

In this paper, a multivariable PI/PID controller design method based on dominant pole placement approach for two-input-two-output (TITO) interactive processes is proposed. First the TITO process is decoupled into two higher order decoupled processes through a decoupler matrix. Next, a first order plus dead time (FOPDT) model is determined for each higher order decoupled processes. Then, diagonal PID controller is obtained for given performance specifications using the guaranteed pole placement method. The off-diagonal controller of multivariable controller is obtained by simply multiplying diagonal controller with decoupler elements. This higher order off-diagonal controller is reduced in PI form by using Maclaurin series. The performance of the proposed design method is verified on the original interactive system to show its effectiveness for the general class of the TITO systems. Two simulation examples for TITO processes are incorporated to validate the usefulness of the presented algorithm. It can be observed that the high closed-loop performance is obtained using proposed design method and it is comparable with the recent method available in the literature.
Abstract 5701: HDAC inhibition decreases YAP1 expression but parodoxically activates TEAD transcription by the AP-1 pathway in breast cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract The Hippo pathway is an evolutionally conserved pathway that is crucial in numerous aspects of cell biology, including contact inhibition, cell density, and others. Hippo pathway is well reported to be dysregulated in multiple cancer types and plays important oncogenic roles in human cancers. In mammalian cells, YAP is regulated by a phosphorylated cascade mediated by the kinases MST1/2 and LATS1/2, known as the canonical Hippo pathway. These upstream kinases phosphorylate YAP/TAZ and leads to its cytosolic degradation. Perturbation of the Hippo pathway leads to YAP intranuclear translocation and downstream activation of target genes, inducing proliferative signals and thus initiating oncogenesis. Novel mechanism linking the hippo pathway to various oncogenic mechanisms are rapidly discovered and reported, further establishing the significance of this pathway and its role in cancer biology. Breast cancer is the top leading cause of cancer in women and poses a significant morbidity and economic burden on society. Hormone positive (defined as positivity of the estrogen receptor ER and/or the progesterone receptor PR) breast cancer composes 70% of breast cancer. Endocrine therapy, chemotherapy, and more recently, CDK4/6 inhibitors and PI3K inhibitors are currently approved strategies towards breast cancer. Histone deacetylase (HDAC) inhibitors have been FDA approved for several hematological cancers, and recently have shown inconsistent results in clinical trials for breast cancer. In our study, we demonstrate and characterize a link between HDAC inhibition and the Hippo pathway. We discover that HDAC inhibitors suppress YAP expression both transcriptionally and translationally. Paradoxically, we demonstrate that although YAP is downregulated, TEAD mediated transcription of downstream Hippo targets is activated. Mechanistically, HDAC inhibition leads to upregulation of the AP-1 transcriptional machinery that cooperates with TEAD to facilitate transcription. By RNA-seq, chromatin studies and CRISPR knockout studies, we confirm that HDAC inhibition have the ability to activate downstream of Hippo pathway, suggesting a possible mechanism for breast cancer resistance towards HDAC inhibitor. Co-targeting HDAC inhibition and AP-1 results in enhanced efficacy of HDAC inhibitors and may be a promising approach for development towards breast cancer. Citation Format: Ting-Yi Lin, Yi-Ru Tseng, Naikuan Wang, Ta-Chung Chao, Chun-Yu Liu, Ling-Ming Tseng, Jiun-I Lai. HDAC inhibition decreases YAP1 expression but parodoxically activates TEAD transcription by the AP-1 pathway in breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5701.
The adjoint algebra for 2-categories

Field: Mathematics (Physical Sciences)

For any 0-cell B in a 2-category B, we introduce the notion of adjoint algebra AdB. This is an algebra in the center of B. We prove that if C is a finite tensor category, this notion applied to the 2-category CMod of C-module categories coincides with the one introduced by Shimizu. As a consequence of this general approach, we obtain new results on the adjoint algebra for tensor categories.
Modular Nucleic Acid Surrogates. Solid Phase Synthesis of α-Helical Peptide Nucleic Acids (αPNAs)

Field: Chemistry (Physical Sciences)

[formula: see text] The synthesis and characterization of prototype alpha-helical peptide nucleic acid (alpha PNA) modules 1-3 as well as disulfide dimers 4 and 5 are reported. These molecules combine an alpha-helical peptidyl scaffold with well-defined nucleobase molecular recognition patterns and could serve as a basis for novel antisense and/or antigene agents. Structure assignments for these alpha PNAs were supported by MALDI-TOF mass spectrometry, and the alpha-helical nature of 4 in water was confirmed by circular dichroism (CD) spectroscopy.
INDUCED- GROWTH AND YIELD RESPONSES TO THREE DIFFERENT CONCENTRATIONS OF COLCHICINE ON SELECTED TRAITS IN TWO VARIETIES OF EGG PLANT (Solanum melongena L.)

Field: Agricultural and Biological Sciences (Life Sciences)

The effect of Colchicine induced mutation on the growth and yield of two varieties of Egg plant was investigated with the aim of inducing variability that could be exploited in the improvement of some quality traits in Egg plants. Three different treatments of Colchicine were applied on to the two Egg plant varieties. The seeds of the two varieties of egg plant: White Egg plant and Green Apple varieties were treated with three different concentrations of Colchicine (0.1mM, 1.0 mM, 2.0 mM and 0.0 mM as control). The results showed significant improvement in almost all the selected traits with decrease in the mutagen concentration for the two varieties except in the fruit diameter where an increase in the mutagen concentration was observed. It was generally observed that, 0.1mM concentration of colchicines is significant in inducing variability that could be exploited in the improvement of highly economic crops like Egg plant.
Finding the optimum groin layout for the Konaweha river banks protection via 2D numerical modeling

Field: Engineering (Physical Sciences)

Abstract River bank erosion has become a critical issue, especially for river bends with an alluvial soil type. Mostly, river bank erosions have caused structural failures because many national roads in Indonesia are placed near the river bend areas. Groins can reduce flow velocity, thereby increasing riverbank stability. However, most groins were installed in the river without impacting the river flow due to the improper design. This paper analyzes the use of groins placed at the river bend of the Konaweha River to protect the river bank with a length of 250 m from erosion. The evaluation employs 2D numerical modeling using MIKE21 FM to observe the influence of the groin on the river velocity, flow distribution pattern, and water level. Sixteen model scenarios with four groin configurations were tested for 25-year discharge, 2-year discharge, normal discharge 600 m 3 /s, and low discharge 197 m 3 /s to achieve the most effective plan. Based on the simulation results, Scenarios with five groins are recommended to reduce the flow velocity along the outer river bank from 2 to 0.3 m/s, thus minimizing the erosion. In addition, the spacing of groins being twice the groin length is recommended.
Design of a distributed data acquisition and spatial decision making system for precision agriculture

Field: Agricultural and Biological Sciences (Life Sciences)

One of the key technologies for implementing precision agriculture is to collect and process timely spatial-temporal information from various sources that affect crop production in the field. That means the system must integrate the Client's data acquisition and Server's spatial analysis functions, and transfer data rapidly via Internet, by which different decision makers can realize dynamic communication mutually. Using ArcIMS technology framework and ArcXML language, a technology system was designed. The system has four functional modules, including data acquisition, data handling, information analysis, and intellectualized decision making modules. Based on its application in Laixi High-tech Agricultural Demonstration Zone, the system logical design, physical implementation, technical characteristics, and its main functions were described and analyzed. The results show that the system can provide an integrated set of technologies for efficient data acquisition, handling, transferring and decision making, which has good adaptability specifically for precision agriculture.
Building as Refined Object: The Architecture of Antonio Citterio

Field: Arts and Humanities (Social Sciences)

Abstract Sebastiano Brandolini describes the work of Antonio Citterio who, despite a low‐key personal presence on the Italian architectural scene and an architecture of quiet restraint, has gained an enviable international reputation for his elegant and ‘impeccably well‐made’ buildings. Copyright © 2007 John Wiley & Sons, Ltd.
Analysis of the Impact of Technological Innovations in Social Security on the Quality of Life of Older Persons

Field: Health Professions (Health Sciences)

As technological innovations continue to be promoted and the problem of population ageing intensifies, the role of the social security sector in enhancing the quality of life of older people is becoming increasingly evident. The aim of this paper is to explore how technological innovations in social security affect the daily lives of older people and their quality of life. A quantitative research methodology was adopted and combined with questionnaire surveys and data analysis techniques to analyse the sample data in depth. It is found that technological innovations play an important role in improving the effectiveness and convenience of social security services, especially in health monitoring, smart services and information access, which significantly enhance the life experience of older people. Further, these innovations have a positive impact on older people's social participation and mental health. Accordingly, this paper argues that strengthening technological innovations in social security is a key way to improve the quality of life of older persons and provides a strong basis for the formulation of relevant policies and development strategies.
Modulation of cellular calcium stores in the perfused rat heart by isoproterenol and ryanodine.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The inhibitory action of procaine on cellular calcium release was utilized to define a new cellular calcium pool which, under physiological conditions, is present only during catecholamine stimulation. Rat hearts labeled with 45Ca++ were perfused with medium containing procaine and EGTA at 23 degrees C to remove extracellular calcium, and then cellular calcium was released by removal of procaine and restoration of calcium. By this method we have identified a cellular calcium pool (pool C) whose release is inhibited by procaine, but which does not require extracellular calcium for its release. Release of pool C can also be triggered by caffeine. [We have previously identified a cellular calcium pool (pool A) whose release is triggered by caffeine, inhibited by procaine, and which does require extracellular calcium for its release.] When hearts were labeled for 3 minutes with perfusate containing 1 mM 45Ca++, 48 +/- 6 nmol Ca++/g wet weight was found in pool A, but only 3 +/- 1 nmol Ca++/g in pool C. Howeve...
Kaplan-Meier analyses for relapse-free survival according to miR-210 expression levels.

Field: Medicine (Health Sciences)

<p>(A) Systemically untreated population (N = 73 OXFU); (B) untreated ER-positive population (N = 40); (C) untreated ER-negative population (N = 25). HR: hazard ratio, CI: confidence intervals.</p>
Intrinsically stealth fluorescent organic nanoparticles made of articulated bis-dipolar dyes for single particle tracking

Field: Chemistry (Physical Sciences)

Luminescent nanoparticles are becoming fundamental tools to the field of bioimaging. The optimization of their size, brightness and stability is key for applications ranging from contrast agent assisted surgery to diagnosis and therapeutics. A plethora of formulations have been documented which can be split into inorganic, organic and hybrid categories. While each class has their own advantages and limitations, controlling the interactions occurring between nanoparticles and cellular membranes is of the utmost importance. In particular, a major challenge for various applications, especially molecular imaging of membrane receptors, is to prevent non-specific interactions. Towards this goal, popular strategies based on coating nanoparticles with PEG or zwitterionic moieties have been developed to yield stealth nanoparticles. In this study, we present a series of spontaneously water-soluble and stealth organic nanoparticles. These fluorescent nanoparticles, made from original articulated bis-dipolar dyes, show vanishing interactions with living cells as bare nanoparticles. Moreover, thanks to their brightness and stability, they can be tracked as isolated single emitters in aqueous environments. These stealth nanoparticles thus hold promise for molecular imaging of specific membrane receptors, such as neuronal receptors, after bioconjugation with dedicated targeting agents.
Modified Enzymatic Methods for the Determination of L-(+)-Lactic and Pyruvic Acids in Blood

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Modifications of the enzymatic methods of analyses for L-(+)-lactic and pyruvic acids in whole blood result in average recoveries of 99% for lactate and 100% for pyruvate. The modified lactate procedure facilitates the handling of a large number of analyses. The pyruvate blood recovery studies demonstrated that proper centrifugation following deproteinization is a prime determinant for achieving 100% recovery from whole blood. The importance of technic in performing recovery experiments is emphasized.
SH1291463.08FU

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

UNITE provides a unified way for delimiting, identifying, communicating, and working with DNA-based Species Hypotheses (SH). All fungal ITS sequences in the international nucleotide sequence databases are clustered to approximately the species level by applying a set of dynamic distance values (<0.5 - 3.0%). All species hypotheses are given a unique, stable name in the form of a DOI, and their taxonomic and ecological annotations are verified through distributed, web-based third-party annotation efforts. SHs are connected to a taxon name and its classification as far as possible (phylum, class, order, etc.) by taking into account identifications for all sequences in the SH. An automatically or manually designated sequence is chosen to represent each such SH. These sequences are released (https://unite.ut.ee/repository.php) for use by the scientific community in, for example, local sequence similarity searches and next-generation sequencing analysis pipelines. The system and the data are updated automatically as the number of public fungal ITS sequences grows.
HIV testing and antiretroviral therapy initiation at birth: Views from a primary care setting in Khayelitsha

Field: Health Professions (Health Sciences)

CITATION: Nelson, A. et al. 2015. HIV testing and antiretroviral therapy initiation at birth : views from a primary care setting in Khayelitsha. Southern African Journal of HIV Medicine, 16(1), Art.#376, doi:10.4102/hivmed.v16i1.376.
Gene-expression-based cancer classification through feature selection with KNN and SVM classifiers

Field: Computer Science (Physical Sciences)

This paper presents a study of feature selection methods effect, using a filter approach, on the accuracy and error of supervised classification of cancer. A comparative evaluation between different selection methods: Fisher, T-Statistics, SNR and ReliefF, is carried out, using the dataset of different cancers; leukemia cancer, prostate cancer and colon cancer. The classification results using k nearest neighbors (KNN) and support vector machine (SVM) classifiers show that the combination between SNR's method and the SVM classifier can present the highest accuracy.
Effect of Emotional Intelligence, Commitment, and Motivation Towards Lecturer Performance

Field: Social Sciences (Social Sciences)

Purpose: Make a document key performance indicator associated with emotional intelligence, commitment, and motivation on the performance lecturer at the Universitas Maarif Hasyim Latif Sidoarjo. Design/methodology/approach: The research uses quantitative methods to the associative and using regression analysis techniques and equational structure modeling for determining hypothesis. Findings: The research was based on the findings of non-optimal lecturers performance in carrying out the task, they allegedly a violation of labor discipline, still high levels of absenteeism and tardiness in teaching. Research limitations/implications: Predicting the magnitude of the variation, form relationships and determine the direction and magnitude of effect between the independent variables with the dependent variable. Practical implications: Can document the whole process of planning and strategic steps in efforts to implement the increase in faculty performance through increased emotional intelligence, commitment, and motivation on the performance of a lecturer at the Universitas Maarif Hasyim Latif Sidoarjo. Originality/value: An input for policy making in the improvement and development of the organization and management of universities, in particular, relating to the development Lecturer performance through the development of emotional intelligence, commitment, and motivation more. Paper type: Research paper.
Errors in Positioning of Borehole Measurements and How They Influence Seismic Inversion

Field: Earth and Planetary Sciences (Physical Sciences)

Earth and Space Science Open Archive This preprint has been submitted to and is under consideration at Other. ESSOAr is a venue for early communication or feedback before peer review. Data may be preliminary.Learn more about preprints preprintOpen AccessYou are viewing the latest version by default [v1]Errors in Positioning of Borehole Measurements and How They Influence Seismic InversionAuthorsIrisFernandesKlausMosegaardiDSee all authors Iris FernandesCorresponding Author• Submitting AuthorNiels Bohr InstituteUniversity of Copenhagenview email addressThe email was not providedcopy email addressKlaus MosegaardiDNiels Bohr Institute, University of CopenhageniDhttps://orcid.org/0000-0001-5292-5249view email addressThe email was not providedcopy email address