jimnoneill/paper-to-field-training huggingface dataset:
Faecal mucinase activity assessed in inflammatory bowel disease using 14C threonine labelled mucin substrate.

Field: Medicine (Health Sciences)

Previous studies have shown the presence in faeces of sulphatases, sialidases, glycosidases, and proteases relevant to mucus degradation, but the relative role of these enzymes in the degradation of colonic mucus has been unclear. A total mucinase assay using 14C threonine biologically labelled human colonic mucin as substrate was therefore developed in this study. Faecal mucinase activity of a pooled normal faecal filtrate was capable of removing 80% of the 14C threonine label from mucin within eight hours incubation, but 20% remained intact despite prolonged incubation. The pH profile of mucinase activity is broad (pH 4.5-9.5) suggesting contribution from multiple enzymes. Mucinase activity was reduced by preincubation with 100 micrograms/ml chymostatin (82.8%), 0.5 mg/ml EDTA (91.6%), and 4 g/l bismuth subsalicylate (72.0%). All 55 faecal samples studied contained detectable mucinase activity, measured as dpm release/micrograms protein/hour, which was greater in samples from patients with ulcerative colitis (n = 17, median 52.7, interquartile range 32.9-66.9), than controls (n = 26, 34.4, 26.8-40.4, p < 0.02) or patients with Crohn's disease (n = 12, 35.5, 17.5-55.7, p < 0.05). There was, however, no significant difference in faecal mucinase activity between inactive and active ulcerative colitis. These results suggest that faecal mucinase activity is one factor contributing to the thin mucus layer in ulcerative colitis and represents a potential target for drug treatment.
La Disjonction de la Voix Narrative et la Manipulation de la Vraisemblance dans "Le Rocher de Tanios" d'Amin Maalouf

Field: Arts and Humanities (Social Sciences)

This investigation of the narrative voice in Maalouf’s Prix-Goncourt winning novel Le Rocher de Tanios observes the manner in which the multiplicity of enunciators, in the form of secondary narrators “cited” intertextually by the primary narrator, engenders a subtle play upon points of view, epochs, and cultural outlooks, an artifice which lends the novel a breadth in its generic status and veridictory grounding. It manages to be both an entirely possible, realistic narrative, and a fantastical legend, in which the “strange and the marvelous”, in the words of one of the secondary narrators, form a counterpoint against the rigorous historical research of the primary narrative. The result is a tale in which the appearance of a coherent and inevitable progression of providence melds with a capricious logic of chance events. The work raises the question of fiction and history and answers yes to each one; it is not only a fiction aspiring to verisimilitude, but conversely, it is also an actual history transformed into a novel – into the sort of novel that leads the reader to question his sense of truth and falsehood.
Investigation of serum Cu, Zn-SOD concentration by ELISA and histological localization in hepatocellular carcinoma(HCC) using anti-human Cu, Zn-SOD monoclonal antibody.

Field: Medicine (Health Sciences)

肝細胞癌患者における血清Cu, Zn-SOD濃度および組織学的局在についてCu, Zn-SODモノクローナル抗体をもちいて検討した.肝細胞癌患者の血清Cu, Zn-SOD値は,健常者,肝硬変患者に比べ有意に上昇していたが,血清GPT, GOT, AFP値との間に相関関係はなかった.これまで,腫瘍部におけるCu, Zn-SOD活性の低下を報告したものは,数多くあるが,われわれの組織学的検討では20%の標本で腫瘍部のCu, Zn-SODは強く染色された.このことは,腫瘍部でCu, Zn-SODが量的に増加していることを示唆しているものと思われる.これらの結果より,Cu, Zn-SODが肝細胞癌において新しい腫瘍マーカーになる可能性と,Adriamycinなどおもに活性酸素により癌細胞を破壊する制癌剤に抵抗する肝細胞癌が存在する根拠となる可能性が示唆された.
NXDOMAIN really means there is nothing underneath

Field: Computer Science (Physical Sciences)

This document states clearly that when a DNS resolver receives a
response with response code NXDOMAIN, it means that the name in the
question section AND ALL THE NAMES UNDER IT do not exist. REMOVE
BEFORE PUBLICATION: this document should be discussed in the IETF
DNSOP (DNS Operations) group, through its mailing list. The source of
the document, as well as a list of open issues, is currently kept at
Github [1].
Deadlock detection and resolution in automated material handling system

Field: Decision Sciences (Social Sciences)

Adoption of automated guided vehicles (AGVs) by container terminals has been rapid in recent years. This is especially true in Singapore, with PSA International Pte. Ltd seeking to develop AGVs prototype in bid to increase their efficiency and throughput. However, there is a possibility where the quay cranes, stacking cranes and AGVs request for each other directly or indirectly to start a loading or unloading operation. This leads to a halt among the affected resources and creates a condition call deadlock. In this project, a method to detect deadlocks when it occurs is presented. The method first introduced a way to represent resource allocation graph via a matrix. Matrix operations to reflect real time updates from the system is then proposed, and deadlock can be identified when the matrix detects a cyclic relationship among the resource.A simulation study is done to create the condition of deadlock and test the viability of the detection method proposed. To replicate a realistic scenario present in a real world container terminal, a scenario generator is written to provide input data to the simulation model.Two approaches are discussed to resolve the deadlocks that occur in automated container terminal. The appropriateness under which approaches should be called is discussed, where the approach with minimum impact on the terminal operation should always be called for if condition allows. These resolution procedures aim to modify the handling sequence of the resources involved in the deadlock so that the cyclic request relationship can be broken off.Finally, the performance of the system is analysed and a parameter sweep on the number of AGVs is done to study how performance of terminal is affected by its change.
STUDIES ON ANTIBODY PRODUCTION V. Tm ~ S~.com)A~Y P~sPoNs&apos;z. m VITRO*

Field: Immunology and Microbiology (Life Sciences)

Students of antibody formation have long forecast the advantages to be gained from the successful cultivation of ceils from lymphatic tissue. The opportunity to investigate antibody formation in cell lines derived from single ancestors, for example, or to follow the events begun by the first exposure to antigen, would be invaluable in unraveling this complex biological process. So far, such hopes have proved elusive. Occasional reports of the successful stimulation of tissue from normal spleen to form antibody (1-3) have appeared, but none has as yet been confirmed. A more successful approach has been the cultivation in vitro of cells or fragments from the lymphatic tissue of previously immunized animals repeatedly stimulated in vivo. This technique has permitted study of some aspects of the synthetic process already in progress (4-7). An extensive summary has recently been published by Stavitsky (8). The experiments reported in this paper were undertaken to determine whether it was possible to initiate a secondary response in surviving tissue from the lymph node of rabbits.previously injected once with antigen, but in which
The Queen Mother and the Cult in Ancient Israel

Field: Arts and Humanities (Social Sciences)

Research Article| October 01 1993 The Queen Mother and the Cult in Ancient Israel Susan Ackerman Susan Ackerman Search for other works by this author on: This Site Google Journal of Biblical Literature (1993) 112 (3): 385–401. https://doi.org/10.2307/3267740 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Permissions Cite Icon Cite Search Site Citation Susan Ackerman; The Queen Mother and the Cult in Ancient Israel. Journal of Biblical Literature 1 January 1993; 112 (3): 385–401. doi: https://doi.org/10.2307/3267740 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveSBL PressJournal of Biblical Literature Search Advanced Search The text of this article is only available as a PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
Abstract 5256: Toward biomarkers discovery: Profiling triple-negative breast cancer cells by cell-SELEX

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Triple-negative breast cancer (TNBC) is a high heterogeneous group of tumors with a distinctly aggressive nature and high rates of relapse. So far, the lack of any known targetable proteins has not allowed a specific anti-tumor treatment, thus the identification of novel agents for specific TNBC recognition and treatment is desperately needed. Nucleic acids aptamers are emerging as the most promising candidates for targeting tumor cells. They are also termed "chemical antibodies" because their form unique tertiary structures, which allow specific binding to their target molecules. Recently, by cell-SELEX integrated to advanced Next Generation Sequencing and bioinformatics, we isolated a panel of six nuclease-resistant RNA aptamers able to bind at high affinity to TNBC cells, discriminating them from both normal cells and non-TNBC breast cancer cells, and interfere with their growth as mammospheres. Also, they diversify TNBC histological specimens in a tissue microarray without recognizing samples from both ER+, PR+, HER2+ breast cancers and normal adjacent tissues. Here, short versions of the aptamers have been generated, by truncating their length from 84 nt up to nearly 30 nt, which preserve efficacious targeting and anti-tumor properties as the parental moieties. In order to identify the targets of the above aptamers, which might be important surface cancer biomarkers crucial for the malignant phenotype, different biochemical approaches are harnessed that include aptamer-mediated affinity purification coupled to Mass Spectrometry and/or antibody array for human soluble receptors. Binding analyses on recombinant proteins, cells or tissues are used to verify the putative targets. Results obtained so far indicate that the target of one of the six aptamers is a secreted protein tightly and specifically associated to TNBC cell surface and with a poor prognosis. This protein identification and the functional role of its targeting by the aptamer will be shown here in detail. The proposed cell-targeting aptamer strategy could provide an important new avenue for selective TNBC therapy. Citation Format: Simona Camorani, Francesco Leonetti, Francesca Collina, Monica Cantile, Gerardo Botti, Antonella Zannetti, Monica Fedele, Laura Cerchia. Toward biomarkers discovery: Profiling triple-negative breast cancer cells by cell-SELEX [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 5256.
Investigation of protein-ligand interactions using high-throughput all-atom molecular dynamics simulations

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Investigation of protein-ligand interactions has been a long-standing application for molecular dynamics (MD) simulations given its importance to drug design. However, relevant timescales for biomolecular motions are orders of magnitude longer than the commonly accessed simulation times. Adequate sampling of biomolecular phase-space has therefore been a major challenge in computational modeling that has limited its applicability. The primary objective for this thesis has been the brute-force simulation of costly protein-ligand binding modeling experiments on a large computing infrastructure. We have built and developed GPUGRID: a peta-scale distributed computing infrastructure for high-throughput MD simulations. We have used GPUGRID for the calculation of protein-ligand binding free energies as well as for the reconstruction of binding processes through unguided ligand binding simulations. The promising results presented herein, may have set the grounds for future applications of high-throughput MD simulations to drug discovery programs.
POTENSI JERAMI PADI SEBAGAI BAHAN BAKU PANEL AKUSTIK

Field: Engineering (Physical Sciences)

In the increase of environmental noise, building elements enriched with acoustical properties are significant to serve amenities and healtiness among inhabitants. However, this type of elements which usually consist of high quality materials is much too expensive for most people. The use of paddy straw as the main material to construct acoustical panels is considered in a very early stage of material research. Paddy straw has chareacteristics which is close to acoustical requirements of panels, besides abundance of availability. These benefits will significantly lowered cost production without significantly reduce the quality. Further research to seek the next step of application of paddy straw as acoustic panels is in conduct. Abstract in Bahasa Indonesia : Kebisingan di sekitar bangunan yang terus meningkat serta naiknya permintaan bahan bangunan yang bersifat akustik untuk keperluan studio pribadi telah menyebabkan kebutuhan bahan bangunan yang bersifat akustik juga meningkat. Namun, bahan semacam ini tidak secara merata terjangkau masyarakat. Penggunaan bahan limbah, salah satunya jerami padi sebagai bahan baku pembuatan panel akustik, diharapkan mampu memenuhi kebutuhan bahan bangunan bersifat akustik dengan kualitas tinggi namun tetap dalam harga bersaing. Jerami padi menjadi bahan yang realistis dipertimbangkan sebagai bahan utama karena ketersediaannya yang melimpah dan sifat-sifat fisik batangnya yang secara teoretis mampu menjadi bahan akustik yang baik. Penelitian lanjutan ke arah pemanfaatan limbah jerami padi sebagai bahan baku panel akustik sedang dilaksanakan. Kata kunci: panel akustik, jerami padi.
Effectiveness of Professional Development Programs in Indonesia: A Survey of Educators’ Perspectives on Training and Support

Field: Social Sciences (Social Sciences)

This study examines the effectiveness of professional development (PD) programs in Indonesia from educators’ perspectives, focusing on training quality, content relevance, implementation, and follow-up support. Using a descriptive quantitative research design, data were collected from 47 teachers across eight junior and senior high schools in Sorong City through a structured questionnaire. The results indicate that PD programs are highly beneficial in enhancing teachers’ knowledge, introducing innovative teaching strategies, and improving student learning outcomes. Key factors influencing effectiveness include engaging and interactive training formats, knowledgeable facilitators, and collaborative opportunities among educators. Teachers also reported increased confidence in their teaching abilities and observed positive changes in student engagement. However, challenges such as scheduling constraints by limiting time for deep learning, causing cognitive overload, and reducing opportunities for follow-up and reflection. Also, the need for sustained institutional support were noted. The study concludes that PD programs significantly contribute to teacher effectiveness and professional growth. To optimize their impact, continuous mentorship, flexible program structures, and alignment with real classroom challenges should be prioritized.
Influence of ageing on depolarization currents in polymer-insulated medium-voltage cables

Field: Engineering (Physical Sciences)

Depolarization currents in a larger number of virgin and aged polymer-insulated medium-voltage cables have been measured as a function of the magnitude of the applied electric field. In comparison with new cables some service-aged cables revealed unusual dielectric properties. As expected, unaged cables show a lineal relation between the depolarization current and the polarizing field at moderate electric field strengths. In contrast, for many service-aged cables a more than proportional increase of the depolarization current with the applied electric field was observed (indicating some nonlinearity). Visual inspection of the cables showed a very high density of bow-tie trees in the 'non-linear' cables. Furthermore, it was observed that the nonlinearity vanished when the cable was dried and reappeared again after wetting the cable. As a conclusion from these observations, it is believed that the non-linear dielectric behaviour is a consequence of the presence of bow-tie trees in the cables. In our opinion it may be worthwhile considering the measurement of depolarization currents as a diagnostic measurement technique to detect water trees in buried cables.
INDUCED INFRARED ABSORPTION OF $D_{2}$ IN $D_{2}$-He AND $D_{2}$-Ne MIXTURES AT DIFFERENT TEMPERATURES

Field: Physics and Astronomy (Physical Sciences)

$^{1}$ S. T. Pai. S.P. Reddy and C.W. Cho, Can. J. Phys. 44, 2893 (1965). $^{2}$ J. Van Kranendonk, Physica 23, 825 (1957); 24, 347 (1958).
‘Vilmos’ Peach: A New and Improved “Stay-ripe” Processing Clingstone Peach Ripening in the ‘Andross’ Maturity Season

Field: Agricultural and Biological Sciences (Life Sciences)

Additional index words.breeding, fruit, stay-ripe 'Vilmos' peach [Prunus persica (L.) Batsch] produces a clingstone fruit with nonmelting flesh and is suitable for processing or fresh market.Fruit can maintain quality and firmness for up to 4 weeks after the initial tree-ripe stage.This ''stay-ripe'' trait allows delayed harvest, including once-over and mechanical harvest when all fruit on the tree have achieved commercial tree-ripe quality.Evaluated as selection UCD-91,9-161, it was derived from a cross between 'Loadel' and breeding selection UCD-F10E,6-27.Ripening time is during the commercially important 'Andross' period, 4 d after 'Fay Elberta'.Long-term commercial evaluations have shown that fruit demonstrated very good harvest, postharvest, and processing quality with low susceptibility to fruit brown rot, pit fragmentation, and associated red anthocyanin staining.Fruit possess good size and color that are similar to the commercially important 'Andross' and 'Ross'.Trees have proven to be consistently productive during more than 14 years of commercial evaluation.Tree form is semi-upright, with vigor and branch architecture similar to those of 'Andross'.Flowers are pink and nonshowy.Leaves are medium to dark green with globose glands.
Cultivation of oyster mushroom to combat pandemics: medicinal and social aspects

Field: Agricultural and Biological Sciences (Life Sciences)

Mushrooms are the spore bearings fruiting bodies that have been used by human being since ancient times for good health. Mushroom is the choicest food of nutrition because it provides important nutrients like proteins, selenium, potassium, riboflavin, Niacin, Vitamin D and more. Oyster mushroom are known for their health benefits. Oyster mushroom protect the heart against cardiovascular diseases, helps in lowering the blood pressure, regulate the cholesterol level, improve immune health and have anti cancer, anti inflammatory and other properties. , Cultivation of oyster mushroom on waste straw not only solve the pollution problem but also improves the economic conditions of farmers.
Creating a hydrosocial territory: water and agriculture in the Liwa Oasis

Field: Environmental Science (Physical Sciences)

This article presents the Liwa Oasis as a hydrosocial territory. It is defined by its natural resource, social, economic, and political context and we show how these manifest in policy and practice. The article identifies these components through analysis of the political economy of water management and agricultural production systems. Two distinct hydrosocial periods are defined: from independence in 1971 to the formation of agencies with water sustainability remits in 2006, and then from 2010 to the present, when subsidy regimes incentivized changes to cropping in existing agricultural production systems. The changes between these periods reflect alterations in the hydrosocial cycle stemming from natural resource degradation and from how agricultural policy responded to it, while still meeting social stability and food security objectives. In Liwa, water management and agricultural production regimes reflect the distributive nature of the state, in that agricultural subsidies and payments are a significant source of supplementary income for UAE citizens. The current hydrosocial cycle leads to major groundwater resource degradation, which is beginning to pose a major challenge. This disruption is at the heart of the hydrosocial dialectic playing out now in Liwa: resource degradation and depletion will ultimately require new patterns of resource utilization. Arriving at new practices will require new laws, policies and modes of governance, which will alter the political, social, and economic context.
A consensus proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

Field: Neuroscience (Life Sciences)

Abstract Background Our understanding of the biological changes in the brain associated with Alzheimer’s disease (AD) pathology and cognitive impairment remains incomplete. Unbiased discovery proteomic analysis of AD brain can help to increase our understanding of these changes. Method We analyzed dorsolateral prefrontal cortex, precuneus, and temporal cortex of control, asymptomatic AD, and AD brains from multiple different centers by label‐free quantitative mass spectrometry and weighted protein co‐expression analysis to obtain a consensus protein co‐expression network of AD brain. We also analyzed cerebrospinal fluid to investigate potential biomarkers related to this network. Result The network consisted of 13 protein co‐expression modules. Six of these modules correlated with amyloid‐β plaque burden, tau neurofibrillary tangle burden, cognitive function, and clinical functional status, and were altered in asymptomatic AD, AD, or in both disease states. These six modules reflected synaptic, mitochondrial, sugar metabolism, extracellular matrix, cytoskeletal, and RNA binding/splicing biological functions. The identified protein network modules were preserved in a community‐based cohort analyzed by a different quantitative mass spectrometry approach. They were also preserved in temporal lobe and precuneus brain regions. Some of the modules were influenced by aging, and showed changes in other neurodegenerative diseases such as frontotemporal dementia and corticobasal degeneration. The module most strongly associated with AD pathology and cognitive impairment was the sugar metabolism module. This module was enriched in AD genetic risk factors, and was also highly enriched in microglia and astrocyte protein markers associated with an anti‐inflammatory state, suggesting that the biological functions it represents may serve a protective role in AD. Proteins from the sugar metabolism module were increased in cerebrospinal fluid from asymptomatic AD and AD cases, highlighting their potential as biomarkers of the altered brain network. Conclusion In this study of >2000 brains and nearly 400 cerebrospinal fluid samples by quantitative proteomics, we identify proteins and biological processes in AD brain that may serve as therapeutic targets and fluid biomarkers for the disease.