jimnoneill/paper-to-field-training huggingface dataset:
Molecules from Staphylococcus aureus that bind CD14 and stimulate innate immune responses

Field: Immunology and Microbiology (Life Sciences)

Mammals mount a rapid inflammatory response to gram-negative bacteria by recognizing lipopolysaccharide (LPS, endotoxin). LPS binds to CD14, and the resulting LPS-CD14 complex induces synthesis of cytokines and up-regulation of adhesion molecules in a variety of cell types. Gram- positive bacteria provoke a very similar inflammatory response, but the molecules that provoke innate responses to these bacteria have not been defined. Here we show that protein-free, phenol extracts of Staphylococcus aureus contain a minor component that stimulates adhesion of neutrophils and cytokine production in monocytes and in the astrocytoma cell line, U373. Responses to this component do not absolutely require CD14, but addition of soluble CD14 enhances sensitivity of U373 cells by up to 100-fold, and blocking CD14 on monocytes decreases sensitivity nearly 1,000-fold. Deletion of residues 57-64 of CD14, which are required for responses to LPS, also eliminates CD14-dependent responses to S. aureus molecules. The stimulatory component of S. aureus binds CD14 and blocks binding of radioactive LPS. Unlike LPS, the activity of S. aureus molecules was neither enhanced by LPS binding protein nor inhibited by bactericidal/permeability increasing protein. The active factor in extracts of S. aureus is also structurally and functionally distinct from the abundant species known as lipoteichoic acid (LTA). Cell- stimulating activity fractionates differently from LTA on a reverse- phase column, pure LTA fails to stimulate cells, and LTA antagonizes the action of LPS in assays of IL-6 production. These studies suggest that mammals may use CD14 in innate responses to both gram-negative and gram-positive bacteria, and that gram-positive bacteria may contain an apparently unique, CD14-binding species that initiates cellular responses.
Working backwards: Broome's World War II flying boat wreck sites reconstructed from archaeological non-disturbance surveys

Field: Arts and Humanities (Social Sciences)

The students, sitting in a classroom cluttered with a variety of twisted and broken airplane parts, study the image. A few hands hesitantly go up...'It looks like he overran the runway,' one student says...'No,' Wall retorts, clearly ready for just that sort of response. 'Describe factually what you are seeing, and leave your opinions at home'...The rest of the hands go down. Wall helps them out: 'The right side of the forward fuselage has compression buckling. The props are not feathered. There is substantial deformation with crushing. And see these people walking around? Have they touched anything? You now have a contaminated investigative area.' For this group of 33 aspiring air crash investigators, school has begun (Adams, 2001: 1).
Study on Relationship between the Amount of Metabolites of No051 Endophytic Fungi and Incubation Time

Field: Agricultural and Biological Sciences (Life Sciences)

[Objective] The paper was to study the relationship between the amount of metabolites of No051 endophytic fungi and incubation time.[Method]The No051 endophytic fungi isolated from root-zone soil in northwest area of Liaoning province was used as materials,and it was cultured in liquid.The dry matter weight of secondary metabolites was measured after 5,9,13,17,21 and 25 days,respectively,and high performance liquid chromatography(HPLC) analysis was carried out.[Result]The production of secondary metabolites reached the peak in 9 days-cultivation.The HPLC analysis showed that higher content of active substances in the secondary metabolites in 9 days as well.[Conclusion]The study provided a theoretical basis for the further study of secondary metabolites of No051endophytic fungi.
MON-193 Ovarian-Specific Cyp17A1 Overexpression in Female Mice: A Novel Model of Endogenous Testosterone Excess

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Disclosure: S. Wu: None. Excessive androgen levels can severely affect female health. However, most existing models of androgen excess rely on exogenous androgen administration, which does not fully capture the impact of elevated local ovarian testosterone on reproductive and metabolic functions. Here, we report the development of a novel hyperandrogenic mouse model, Cyp17TM-625, generated by combining CRISPR-Cas9 and a Tet-On doxycycline system to induce Cyp17A1 overexpression in ovarian theca-interstitial cells. As a result, Cyp17TM-625 mice exhibited significantly elevated Cyp17A1 mRNA and protein levels, accompanied by increased testosterone concentrations without alterations in basal levels of estradiol, progesterone, LH, or FSH. These mice demonstrated subfertility, evident by smaller and fewer litters, prolonged estrous cycles, and an increased number of secondary and unhealthy follicles with abnormally shaped oocytes. Despite these marked reproductive changes, body weight and glucose homeostasis remained comparable to Con-625 mice. Notably, withdrawal of doxycycline reversed Cyp17A1 overexpression and partially restored fertility. In summary, this model recapitulates reproductive dysfunction but not the metabolic disturbances, commonly observed in exogenous androgen models. The Cyp17TM-625 mouse line is a unique model for investigating the effects of local excess androgens on ovarian function. It also serves as a valuable tool for studying fertility restoration following the withdrawal of testosterone. Presentation: Monday, July 14, 2025
Ameliorative effect of visnagin against colitis derived hepatoxicity by dextran sodium sulphate in C57BL/6 mice

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The present study was conducted to investigate hepatic damage associated with Dextran sodium sulphate (DSS) induced ulcerative colitis (UC) and to evaluate the ameliorative effect of Visnagin (VIS) against this hepatic damage. Six groups of C57BL/6 male mice, each containing six animals viz. Group 1 (Normal), Group 2 (DSS @ 2% with 3 cycles of 5 day intervals diluted in distilled water administered orally), Group 3 (VIS @ 60 mg/kg b.wt., orally), Group 4 (VIS @ 30 mg/kg b.wt. and DSS), Group 5 (VIS @ 60 mg/kg b.wt. and DSS) and Group 6 (Dexamethasone sodium @ 1 mg/kg b.wt. IP and DSS). After the 31-day experimental period, organ weights, serum analysis, oxidative stress parameters, inflammatory cytokines, gross and histopathology and immunohistochemical analysis were evaluated on day 32. Group 2 mice (DSS only) showed significant increase in ALT, AST, MDA and nitrite levels, along with elevated pro-inflammatory cytokines levels. Conversely, significant decreases in total protein, albumin levels, antioxidant enzymes levels (SOD, CAT and GSH) and IL-10 concentrations were observed. Histopathological examination revealed severe degenerative changes in the livers of Group 2, with increased NF-κB immunoexpression and reduced Nrf2 protein expression. Groups 4 and 5 treated with VIS, showed dose-dependent improvements with moderate to mild changes attributed to VIS’s anti-inflammatory and antioxidant properties likely through modulation of the Nrf2 signaling pathway. Group 6 treated with Dexamethasone, also showed improvement in all these parameters. In conclusion, VIS demonstrated notable anti-inflammatory and anti-oxidant properties against DSS-induced hepatotoxicity.
New aspects in enzymatic peptide synthesis

Field: Chemistry (Physical Sciences)

The use of proteases for peptide bond formation is now a well established procedure which is complementary considered along with the chemical methods for two main reasons: The first one is related to the mildness of the process as compared to the chemical carboxylic activation, avoiding thus any racemization problem which is often a drawback during the chemical coupling of peptide fragments. The second advantage presented by this biocatalysis can be related to the high regiospecificity of enzymes which allows the use of unprotected side chain components. This review describes recent trends in protease catalysed peptide synthesis in either high or low water content media: briefly, in the former case, the utilization of new specific or site-modified proteases has been reported whereas in the second one, native or modified enzymes have been applied as biocatalysts in organic solvent. Prospects about the newly field of abzymatic peptide synthesis are drawn at the end of this article.
Carbamodithioate‐based fluorescent chemosensor for Hg(II): a staged response approach and investigation into the sensing mechanism

Field: Chemistry (Physical Sciences)

Abstract Carbamodithioate‐based compound C1 was designed and synthesized as a new fluorescent probe for Hg 2 + ions. Upon the addition of Hg 2 + ions, it displayed a rare staged response: the emission spectra of C1 first showed an apparent red‐shift, followed by a dramatic decrease. To investigate the sensing mechanism, control compounds C2 with the same phenanthroimidazole unit and C3 with the same carbamodithioate functionality were synthesized. On comparison, the first step sensing process was ascribed to decreasing photoinduced electron transfer on the coordination of Hg 2 + with the lone pair electrons of the nitrogen atom on the phenanthroimidazole ring. The affinity of Hg 2 + and the carbamodithioate unit with four sulfur atoms then induced changes in intramolecular charge transfer efficiency and the second step fluorescent response.
Uncertainty Quantification Using Surrogate Models

Field: Engineering (Physical Sciences)

Uncertainty quantification (UQ) in aerodynamic simulations is retarded by the high computational cost of CFD models. With gradient information obtained at a reduced cost by using an adjoint solver, gradient-employing surrogate methods are promising in speeding up the UQ process. \n To investigate efficiency of UQ methods we apply gradient-enhanced radial basis functions, gradient-enhanced point-collocation polynomial chaos, gradient-enhanced Kriging and quasi-Monte Carlo quadrature to a test case where the geometry of a RAE2822 airfoil is perturbed by a Gaussian random field parameterized by 10 independent variables. The four methods are compared in their efficiency in estimating some statistics and probability distribution of the uncertain lift and drag coefficients. The results show that with the same computational effort the gradient-employing surrogate methods achieve better accuracy in the UQ than the QMC does.
A Study on the Influence of Job Characteristics on Job Satisfaction of Freight Forwarder

Field: Business, Management and Accounting (Social Sciences)

본 연구에서는 직무특성을 직무의 중요성, 직무의 자율성, 직무의 환류성, 직무의 기술다양성으로 구분하고 이러한 직무특성들이 프레이트 포워딩 직무 종사자들의 직무만족에 미치는 영향에 대하여 분석하고, 프레이트 포워더 직무 종사자들의 개별특성에 따라 직무특성이 직무만족도에 미치는 영향에 대해 차이가 있는지에 대해 분석하였으며, 다음과 같은 연구결과가 나타났다. 첫째, 직무특성이 직무만족에 미치는 영향에 대해 분석한 결과 직무특성 중 직무의 중요성과 직무의 환류성이 직무만족에 긍정적인(+) 영향을 미치는 것으로 분석되었다. 둘째, 프레이트 포워딩 직무종사자들의 개별특성에 따라 직무특성이 직무만족도에 미치는 영향에 대해 차이가 있는지에 대해 확인하기 위해 Chow Test를 통해 조절효과를 검증하고자 하였다. 분석결과 두 가지 개별특성 모두 조절변수로써 효과가 있는 것으로 나타났다. 셋째, 관련학과 전공의 유무가 조절변수로써 효과가 있음에 따라, 관련학과 전공/비 관련학과 전공으로 구분하여 다중 회귀분석을 실시하였다. 분석결과 관련학과 전공자들은 직무의 중요성만이 직무만족에 영향을 미치는 것으로 나타났으며, 비 관련학과 전공자들은 직무의 중요성, 직무의 환류성이 직무만족에 영향을 미치는 것으로 나타났다. 넷째, 기업의 분류가 조절변수로써 효과가 있음에 따라, 국내 프레이트 포워더와 외국계 프레이트 포워더로 구분하여 다중 회귀분석을 실시하였다. 분석결과 국내 프레이트 포워더는 직무의 중요성만이 직무만족에 영향을 미치는 것으로 나타났으며, 외국계 프레이트 포워더는 직무의 중요성, 직무의 환류성이 직무만족에 영향을 미치는 것으로 나타났다.
Effect of the DGAT1 K232A polymorphism on milk-fat composition of dairy cows

Field: Agricultural and Biological Sciences (Life Sciences)

A Lys/Ala polymorphism in diacylglycerol acyltransferase 1 (DGAT1) is known to have a large effect on milk-fat percentage in dairy cows; it explains half of the genetic variation in milk-fat percentage. However, its effect on milk-fat composition has not been tested. We measured the fat composition of milk samples in 1,933 Dutch Holstein Friesian cows in their first lactation and genotyped the cows for the DGAT1 polymorphism. Statistical analysis confirmed the large effect of the DGAT1 polymorphism on milk-fat percentage: cows with the KK genotype have a milk-fat percentage of 5.0%, whereas cows with the AA genotype have a milk-fat percentage of 4.0%. The results revealed that this polymorphism has a clear influence on milk-fat composition as well. The A allele of DGAT1 is associated with less saturated fat; 7% smaller fraction of C16:0; and 7%, 10% and 13% larger fractions of C14:0, unsaturated C18, and CLAcis9, trans11. The polymorphism explains substantial proportions of the genetic variance: 53% for unsaturated C18, 40% for C16:0, 23% for C14:0 and 16% for CLAcis9, trans11. The results show that the DGAT1 polymorphism can be used as a marker in selective breeding to improve dairy quality
Estimated dry biomass for summer crops in the subtropical zone in Southern Brazil

Field: Agricultural and Biological Sciences (Life Sciences)

The objective of this study was to calibrate and validate models to estimate dry biomass of maize and soybean crops in the Campos Gerais region, located in the subtropical zone in southern Brazil, with incident solar radiation (Rs), growing degree days (GDD), days after planting (DAP) and precipitation (P) as variables. The experiments were carried out in the 2006/2007 and 2007/2008 harvests in Castro and Ponta Grossa cities, in four phenological stages, to obtain dry biomass. The climate data came from the ABC Foundation agrometeorological stations, installed close to the experimental areas. The parameters adjustment was performed by the Least Squares Method and using a spreadsheet Solver. The soybean harvests with the highest DAP, Rs, and P until physiological maturation were not the ones that obtained the highest final dry biomass productivity, except for the GDD variable. As sowing was performed later, the soybean crop cycle decreased. With the exception of the models' performance for the precipitation variable (between "Terrible" and "Excellent") for soybean and maize crops, the other variables presented promising performances between "Bad" and "Excellent", with a predominance of "Excellent".
A 45nm High Performance Bulk Logic Platform Technology (CMOS6) using Ultra High NA(1.07) Immersion Lithography with Hybrid Dual-Damascene Structure and Porous Low-k BEOL

Field: Engineering (Physical Sciences)

We present the state-of-the-art 45nm high performance bulk logic platform technology which utilizes, for the first time in the industry, ultra high NA (1.07) immersion lithography to realize highly down-scaled chip size. Fully renovated MOSFET integration scheme which features reversed extension and SD diffusion formation is established to meet Vt roll-off requirement with excellent transistor performance of Ion=1100muA/mum for nFET and Ion=700muA/mum for pFET at Ioff=100nA/mum. Also, we achieved excellent BEOL reliability and manufacturability by implementing hybrid dual-damascene (DD) structure with porous low-k film (keff=2.7)
Learning Anthropometry from Rendered Humans

Field: Computer Science (Physical Sciences)

Accurate estimation of anthropometric body measurements from RGB images has many potential applications in industrial design, online clothing, medical diagnosis and ergonomics. Research on this topic is limited by the fact that there exist only generated datasets which are based on fitting a 3D body mesh to 3D body scans in the commercial CAESAR dataset. For 2D only silhouettes are generated. To circumvent the data bottleneck, we introduce a new 3D scan dataset of 2,675 female and 1,474 male scans. We also introduce a small dataset of 200 RGB images and tape measured ground truth. With the help of the two new datasets we propose a part-based shape model and a deep neural network for estimating anthropometric measurements from 2D images. All data will be made publicly available.
Selection of the components of a synthetic variety of Andropogon gayanus

Field: Agricultural and Biological Sciences (Life Sciences)

Andropogon gayanus Kunth var. bisquamulatus Hack, is a polymorphic bunch grass, widely distributed throughout most of the tropical and subtropical savannahs of Africa, south of the Sahara in areas with a long dry season. This grass was introduced into the Colombian Llanos from the Shika Agricultural Research Station, northern Nigeria, in 1974. Subsequent to its introduction, a series of agronomic trials were initiated by Centro Internacional de Agricultura Tropical (CIAT) at the Carimagua Research Centre and various national research institutions in Latin America to evaluate the potential of A. gayanus , primarily in the vast Ultisol and Oxisol savannah regions of the continent. As a result of further evaluation at a number of locations, accession A. gayanus var. bisquamulatus CIAT 621 was released in 1980 in Brazil as cv. Flanaltina and in Colombia as cv. Carimagua 1. During 1982–3 Peru, Venezuela and Panama subsequently released the same accession under the cultivar names of San Martin, Sabanero and Veranero, respectively. It is estimated that 168000 ha have been sown with A. gayanus in Brazil since 1982 (J. E. Ferguson, C. Sere and R. de Andrade, personal communication). Smaller areas have been established in other countries.
Adsorption of Pb(II) in Aqueous Solution by the Modified Biochar Derived from Corn Straw with Magnesium Chloride

Field: Environmental Science (Physical Sciences)

Lead wastewater not only causes deterioration of water quality but also further enters the human body through the food chain and is harmful to human health. Therefore, there is an urgent need to find an economical, simple and efficient water treatment technology to treat lead-contaminated wastewater in waterbodies. In this paper, the modified biochar derived from corn straw by magnesium chloride is prepared. Adsorption experiments of Pb(II) in solution by the modified biochar are carried out. Experiment results show that the modified biochar mainly contains C and O elements, and a large number of functional groups. The adsorption amount of Pb(II) by modified biochar reaches 5.15 mg/g under 0.2 g of modified biochar, 25 mg/L initial concentration of Pb(II) ion, reaction time of 480 min, temperature 25°C and at a speed of 200 rpm. The adsorption process of Pb(II) ions in solution by the modified biochar fits on the Freundlich isotherm model. Pseudo-second order kinetic model can better describe the adsorption process of Pb(II) ion in solution by the modified biochar. The process of adsorbing Pb(II) ions in solution by modified biochar is dominated by multi-layer adsorption process and chemical adsorption process.
EFFECTS OF 8-WEEK ELECTRICAL MUSCLE STIMULATION ON THE MUSCLE CONTRACTILE PROPERTIES IN ADOLESCENT GIRLS

Field: Medicine (Health Sciences)

The study aimed to determine the effect of 8-week unilateral electrical muscle stimulation (EMS) training of leg muscles: vastus lateralis, vastus medialis and biceps femoris with the same number of muscle contractions in comparison to controls. Contractile properties were monitored by measuring the maximal voluntary isometric contraction (MVC) and the rate of force development in first 50 ms (RFD50) of knee extensors and flexors and tensiomyography of stimulated muscles. In addition, we also investigated the retained effect after 8 weeks without EMS training. Nineteen healthy young female athletes aged 15 to 18 years (average 16.4 ± .9 years) were randomly divided in a control group (CG; N=8) and experimental group (EG; N=11). CG performed maximal unilateral voluntary contractions while the EG performed also EMS training of the same leg by stimulating both vasti muscles and biceps femoris. There were no changes in CG after 8-weeks of maximal unilateral voluntary training; however, EG improved MVC in knee extensors (12.6%; P =.085) and RFD50 (142.1%; P =.049) where RFD50 retained increased also 8 weeks after EMS training (73%; P =.090). Tensiomyography revealed decreased amplitude (13.2%; P=.011) only in EG, representing higher muscle tone after 8-weeks of EMS in comparison to CG. Our findings indicate that EMS training has a positive effect on muscle contractile properties in young female athletes even after comparing to matched controls by the number of contractions.
Complex oscillation of non-homogeneous differential equations in the unit disc

Field: Mathematics (Physical Sciences)

In this paper, we investigate the relationship between solutions and their derivatives of non homogeneous linear differential equation for k ≥ 2 and small functions, where are finite order meromorphic functions in the unit disc . We obtain some oscillation theorems for , where f (z) is a solution and ϕ(z) is a small function.
Pencak silat in the modern culture: the role of media in preserving the local heritage

Field: Arts and Humanities (Social Sciences)

ABSTRACTMedia technology is the most important instrument in human life in the global era as it is today. Both social media and mass media in essence occupy a separate role and inseparable from the aspects of modern human life. In an effort to recall the community with martial arts of Pencak Silat which is the indigenous culture of the Indonesian nation that has long been abandoned, many films of martial arts Pencak Silat were produced, many agreed that media is the right choice as a medium for delivering the message of locality embedded in Pencak Silat culture. To understand the martial arts traditions and social figures and imaginary of pendekar as was narrated in media scientifically, then this study applies a socio-historical approach. This approach is expected to produce an explanation that can reveal symptoms of an event which is closely related to the time and place, environment and culture, where the incident took place, and then be able to explain the origin and in terms of social dynamics and the social structure of the society concerned. The study found that movie is an expression and attitude statement, it is even a medium to gain a lot of supports and people?s attentions. Currently, the popularity of martial arts of Pencak Silat as a part of Indonesian local culture is quite successful and very proud, especially because the role of mass and social media is embodied into action movies such as The Raid, Yasmine, and Star Wars 7, as well as through social media and internet Such as Youtube. Film/movie as a medium that has the ability to be used as a counter culture or as a tool to fend off culture or knowledge.Keywords: media; action movies; indigenous culture; pencak silat
ChemInform Abstract: Synthesis of 2,2′‐Bipyrrole‐5‐carboxaldehydes and Their Application in the Synthesis of B‐Ring Functionalized Prodiginines and Tambjamines.

Field: Chemistry (Physical Sciences)

Abstract Several synthetic routes for the synthesis of 3‐ and 4‐substituted 2,2′‐bipyrrole‐5‐carboxaldehydes are developed and the products are utilized to synthesize B‐ring functionalized prodiginines [cf.
Remembering That Which Is Yet to Pass

Field: Arts and Humanities (Social Sciences)

As we all wait for the moment when we can memorialize the ravages of COVID-19 from a point of safety—and even as Wuhan already claims to have arrived at such a moment, as documented in the film 76 Days (Hao Wu, Weixi Chen, Anonymous; 2020)—this article revisits the debates from the turn of the present century on the commemorative drive and the 'culture of amnesia' that it was paradoxically seen as creating at the time. It refracts these debates through two films from the past decade set in the context of pandemics. One of these is a first-person documentary on living with AIDS past the waves of commemoration that attended it in the 1990s and 2000s: What Now? Remind Me! (Joaquim Pinto, Portugal, 2013). The second film is a fiction set amidst a pandemic of amnesia: Embers (Claire Carré, USA, 2015). The dialogue of the theoretical discussions and the films suggests that the rush to archive and commemorate a pandemic, while offering a notable divergence from the forgetfulness that has generally attended pandemics over the past century, may also be a way of postponing its memory.