jimnoneill/paper-to-field-training huggingface dataset:
Screening of Bulgarian Raspberry Cultivars and Elites for Osmotic Tolerance in Vitro

Field: Agricultural and Biological Sciences (Life Sciences)

Abiotic stresses such as drought, high or low temperatures limit in great extend plant distribution and productivity. This is particularly true for perennial crops, including small fruits. Classical breeding for drought, heat and freezing tolerance is a very complex and time-consuming process. Biotechnology approaches could significantly contribute in speeding up the procedures and to make them less dependent on the environment conditions.Using PEG as selective agent under in vitro conditions we were able to distinguish Bulgarski rubin and Elite 1 as osmotic tolerant. Shopska alena, Samodiva, Lyulin and Elite 3 were with reduced growth and membrane integrity of the tissues. Further studies are in progress to compare the reaction to osmotic stress in vitro with the response to drought under field conditions. This will help us to improve and speed up the raspberry breeding program.
Unusual sites and presentations of pilonidal sinus disease

Field: Medicine (Health Sciences)

Pilonidal sinus usually develops in the sacrococcygeal area or other hair-bearing areas. However, it can present at some other sites with varied presentations and can mimic like other infective pathologies which are more common in that area. It has also been described as an occupational hazard in barbers, especially when presented interdigitally. Occupational pilonidal sinuses tend to occur even in non-hair-bearing areas where there is no presence of individual?s own hair. Pilonidal sinus occurs in many areas of the body such as web of fingers, penis shaft, axilla, intermammary area, groin, nose, neck following trauma during shaving, clitoris, sternum, suprapubic area, occiput, prepuce, chin, periungual region, breast, face or navel. Sporadic incidences of implantation of pilonidal sinus have been reported. The disease is mostly observed in hairdressers, but it has also been reported sporadically in other professions, as male sheep shearer, dog groomer, slaughter men or milker of cows. Short customers? hairs that penetrate the supple interdigital skin of the hands produce barber?s disease. Though there are only a few reports about these peculiar sinuses in the available literature, they should be suspected in any chronically discharging, non-healing sinus or wound. A clinical suspicion of malignant transformation or affection with tuberculosis in the endemic area should also be kept in mind to avoid any delay in the treatment and the outcome of the disease.
[Is There a Right to Die?]

Field: Arts and Humanities (Social Sciences)

The right to death is defined from the oblivion of death, characteristic of contemporary society. The defense of euthanasia, far from being a contradiction with that forgetfulness, constitutes its verification. Affirmed as an altruistic and benevolent act conceals the need to forget suffering and death, and the inability to observe the death of others. As a right, the right to death is presented as the prohibition of the law and the community to interfere in the act of love for oneself or for another. But as an effect, a right of a social nature and ethical indication that constitutes a risk for dependent life is established.
Extracellular S100A4 induces human thyroid cancer cell migration

Field: Medicine (Health Sciences)

Human thyroid cancer is the most commonly occurring cancer of the endocrine gland having good survival rate, but some patients show recurrence with an invasive phenotype and treatment failures. The mechanisms behind this invasive phenotype are not well understood in TC. Previously our group has identified a pro-migratory role of relaxin-like peptides in thyroid cancer that is mediated by S100A4. We have observed in human TC cells that extracellular S100A4 induces migration and activates ERK1/2, JNK/SAPK and NFkB signaling pathways. Employing immunohistochemistry and immunofluorescence we have identified the expression of RAGE in human TC primary cells, cell lines, and in tumor tissues but not in normal thyroid tissues. We showed that S100A4 binds to RAGE in TC cells and that RAGE and its cytoplasmic partner Dia-1 mediate the S100A4-induced migration of TC cells. This study identified a crucial role of RAGE in TC cell migration induced by S100A4.
Utilization of standard procedures and workflow according to the school vision and mission

Field: Social Sciences (Social Sciences)

Many school documents are not utilized as work guidelines for program management. How do schools develop the management capacities by utilizing standard procedures and workflow according to the school's vision and mission? This study aims to utilize standard procedures and workflow in line with the school's vision and mission to develop the capacity of program management. The research used a qualitative approach, with a case study method. Case studies were conducted at two sites, focusing on the design of standardized procedures and workflows. Data collection methods used were interviews, field observations, document studies and artifacts. The data validity test was carried out with credibility, transferability, dependability, and confirmability. The results and discussion show that the standard procedures and workflows are understood, visualized and used by teachers and staff, making management performance more organized and focused.
INVOLVEMENT OF TUBERCULOUS MENINGITIS PATIENT WITH HOSPITAL ACQUIRED PNEUMONIAE Case Report

Field: Medicine (Health Sciences)

Meningitis is a global public health problem. The causes can be viruses, bacteria, fungi and parasites. Meningitis is an infectious disease that cannot be overcome and is still a problem in developing countries. As a developing country Indonesia, Tuberculosis has a high number of cases throughout the year. Tuberculous meningitis (TB) is an infection byMycobacterium tuberculosisabout meningor brain parenchyma resulting variety morbidity and mortality. A 39 years old woman came to the emergency room at Drs. H. Amri Tambunan complained of seizures 1 day ago with a duration of more than 1 hour. Seizures are found throughout the body. Also a fever was found 1 day today. Shortness of breath and cough were found for the past 3 days. Decreased appetite has been observed for the past 1 week. There was no history of nausea and vomiting. Os post VP shunt installation on May 29th, 2023. Female patient, 39 years old, with a diagnosis of Tuberculous Meningitis with Hospital Acquired Pneumoniae has been hospitalized from 9 to 20 September of 2023. And also outpatient treatment at the Pulmonology Departement is recommended.
Immediate Results of Small Bowel Crohn’s Disease Surgery

Field: Medicine (Health Sciences)

Introduction: Despite the progress made in the medical management of Crohn's disease (CD), a vast number of patients are operated on at least once in their lifetime. Although this is a mild disease that occurs mainly in young patients with little comorbidity, CD surgery is accompanied by significant postoperative morbidity (PO). This study aims to analyse the PO complications of the small intestine's CD and look for the risk factors for its occurrence. Patients and methods: this is a single-centre prospective study that collected 83 files of patients operated on for CD of the small intestine for 28 months (May 2017 - September 2019). All patients had histologic confirmation of CD. Isolated anoperineal and colorectal forms were excluded from this work. PO morbidity is defined by all complications occurring during the first 30 days of PO. A statistical analysis of PO morbidity was performed as a function of 12 parameters: age; sex; comorbidity; history of abdominal surgery; history of surgery for CD; haemoglobin level (Hb <or> at 10 mg/dl); albumin level (<or> at 34g / l); BMI (<or> at 19); ASA score; mode of surgery (cold vs emergency); intra-abdominal abscess; operative procedure (resection-anastomosis vs resection-stoma). Statistical analysis was performed first univariate and then multivariate (SPSS 16 software). Results: These were 56 women and 27 men, with a sex ratio of 2. The mean age of the patients was 35 years (13-65). The overall PO morbidity rate was 26%; this morbidity was surgical in 86%, septic in 89.5% and intra-abdominal septic in 50% of cases. Complications were major (CMPO) in 39.5% of cases. The mode of emergency surgery was an independent risk factor for the occurrence of complications (p = 0.005). Conclusion: Small intestine CD surgery is associated with very high PO morbidity. The mode of emergency surgery is an independent risk factor for the onset of PO complications. Patients who require surgery should be operated on as elective or scheduled surgery. The indications for emergency surgery for CD are sporadic.
The International Council of Museums and the Controversy about a New Museum Definition – A Conversation with Lauran Bonilla-Merchav, Bruno Brulon Soares, Lonnie G. Bunch III, Bernice Murphy, and Michèle Rivet

Field: Arts and Humanities (Social Sciences)

Abstract In 2019, an Extraordinary General Assembly International Council of Museums (ICOM) met in Kyoto, Japan to vote on a new museum definition. Among other things, the controversial proposal described museums as “democratising, inclusive and polyphonic spaces for critical dialogue about the pasts and the futures” that should also aim “to contribute to human dignity and social justice, global equality and planetary wellbeing.” The motion to postpone the vote, which was supported by a large majority in Kyoto, caused a crisis in the most important international organization for museums and museum professionals. In the years since, ICOM Define led an elaborate consultation process resulting in a newly revised museum definition to be voted on at ICOM’s Extraordinary General Assembly in Prague in August 2022. In this conversation, several prominent members of ICOM who have been deeply involved in the debates about a new museum definition take a critical look at the consultation process before Kyoto, the reasons for postponing the vote, the work of ICOM Define, and also share their expectations for Prague.
A CASE OF A SCHWANNOMA OF THE ASCENDING COLON CAUSING INTUSSUSCEPTION

Field: Medicine (Health Sciences)

消化管に発生する神経鞘腫は比較的稀な疾患であるが，その中でも大腸に発生する神経鞘腫は非常に稀である．今回われわれは上行結腸に発生した神経鞘腫により腸重積をおこした症例を経験したので報告する．症例は42歳女性，検診で便潜血を指摘され当院受診，注腸検査で上行結腸に約3cmの隆起性病変を認め入院となった．大腸内視鏡，超音波内視鏡検査で頂部に陥凹を伴う粘膜下腫瘍を認めた．入院10日目に腹痛出現，右上腹部に腫瘤を触知し，腸重積を疑い注腸検査を行った．上行結腸腫瘍を先進部とした腸重積と診断し，整復を行った．翌日再び腸重積を発症し再度整復を行った．入院14日目に右半結腸切除術を施行した．病理所見では，腫瘍は紡錘形細胞からなり，免疫染色でCD34，c-kit，α-SMA陰性，S-100蛋白陽性でKi-67陽性細胞は2％未満であった．以上より良性の神経鞘腫と診断した．術後1年再発転移は認めていない．
EffeCt of Climate and Cultivation on Organic Carbon and Nitrogen ContenLof Soil

Field: Agricultural and Biological Sciences (Life Sciences)

Studies on the effect of climate and cultivation on organic matter and nitrogen content of virgin and cultivated soils of Orissa were made. Organic matter of a virgin soil increased with increase in rainfall and decrease in temperature. With cultivation, both organic carbon and nitrogen content decreased. Due to cultivation, a loss of about 200-20,000 kg organic carbon and 40–1100 kg nitrogen per hectare were observed in different soil groups, the highest loss being in case of Vertisols. The relationship between the CEC and the organic carbon was significantly positive, whereas the CEC and the soil water retention capacity taken together showed a stronger correlation. Humus was strongly correlated with organic carbon content and this relation followed in the decreasing order with total N, C/N ratio and available N.
Establishment of a Split-Combine Cell-SELEX method for Identification of Nucleobase-Modified Aptamers with Specific Binding to Androgen-independent Prostate Cancer Cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Prostate cancer is the most commonly diagnosed malignancy and the second leading cause of cancer-related mortality in men in the United States. Current therapies, such as chemotherapy, radiotherapy, and photothermal therapy, lack specificity and can cause serious side effects. To address this issue, targeted therapy has gained attention, with antibody-mediated therapy being a mainstay due to its highly specific properties. However, the high cost of production and immunogenicity limit its clinical application. Aptamer-based targeted therapeutics offer several advantages over antibody therapies and have been explored as a potential solution. Aptamers are low molecular ligands, consisting of single-stranded DNA or RNA that can fold into a three-dimensional structure, allowing them to bind with high affinity to specific targets. Aptamers show significant potential in therapeutics and diagnostics, but their ability to interact with a target is limited by the chemical diversity of natural nucleobases. To overcome this challenge, functional groups can be added to the nucleobases to increase chemical diversity. Split-combine SELEX is a technique that enables screening of multiple modifications to the target of interest in a single selection, resulting in the enrichment of nucleobase-modified aptamers with different modifications or the most suitable modification for the selected target. This study introduces a novel approach called split-combine cell SELEX, which utilizes this technology and implemented in the cell-SELEX method to select nucleobase-modified aptamers against prostate cancer cells. Through this method, a new class of clickmers was discovered, which showed the ability to recognize prostate cancer cells with different modifications. It was observed that each modification had a unique impact on the clickmers' binding properties towards prostate cancer cells. Additionally, the S1 aptamer was found to be able to recognize breast cancer cells (MCF-7) when modified with a cyclic-RGD (cRGD), while other modifications (Imidazole) did not produce the same results. Overall, these findings provide insight into the potential of nucleobase-modified aptamers and their diverse binding properties towards cancer cells.
Pelatihan Perangkat Pembelajaran Matematika Berbasis Kurikulum Merdeka bagi Guru PC LP Ma’arif NU Jepara

Field: Social Sciences (Social Sciences)

In welcoming the 21st century, many changes have occurred in various aspects of life, including changes that have occurred in the field of education. One of these changes is the change in the curriculum used as a learning guide in schools. Changes to the Merdeka Belajar curriculum require teachers to follow these changes. However, some teachers are not ready to make and use it. With the PKM training activity on Making Independent Curriculum-Based Learning Tools for Mathematics Teachers, teachers are expected to be able to create independent curriculum-based learning tools and develop learning tools to meet the needs of students in the 21st century. The method for implementing PKM is by collaborating between three parties, namely Universitas PGRI Semarang as the initiator and implementer, as well as LPPM as the party that funds the implementation of PKM, and teachers at PC LP Maarif NU Jepara as PKM targets who will take part in a series of PKM activities. Technically there are 3 stages in implementing PKM activities, namely discussion and coordination to determine problems and plans for implementing activities, implementing PKM activities. From PKM activities, teachers understand more about making independent curriculum-based learning tools, the learning approaches and models used in independent curriculum-based learning tools, and authentic assessments contained in independent curriculum-based learning tools. PKM activities run well and smoothly. The teachers were very enthusiastic in participating in the training activities.
Multicultural Literature and the Politics of Reaction

Field: Arts and Humanities (Social Sciences)

The social climate of the United States of today is dramatically different from that which gave birth to multicultural children's literature. Conservatism's rise to political ascendancy has sharpened the contentious “culture wars” that surround virtually all aspects of American culture. One important dimension of today's conservative movement is a backlash against the multicultural movement. Conservative defenders of the traditional literary canon, for example, see multicultural literature as a threat to the very fabric of Western civilization. Within children's literature circles, charges abound that advocates of multicultural literature are ignoring traditional literary values and are focusing instead on ill-defined notions of “political correctness.” This article explores this complex issue and the challenges it poses to those concerned with the creation, production, distribution, and consumption of children's literature. The discussion addresses questions that speak to the very nature and function of children's literature: its status as art, as entertainment, as a source of role models and ideology for children's “impressionable” minds. Also discussed is the relation between the politically charged question of whether books about African Americans are to be written only by African Americans, books about Native Americans by Native Americans, and so forth, and the freedom of writers to write without restriction.
Orexins?? Brain Cellular Connectivity and Therapeutic Potential in Addiction

Field: Neuroscience (Life Sciences)

Addiction is a disorder of brain reward system, motivation and memory manifested by certain biological, psychological, and social problems. The Lack of most effective and long-term pharmacotherapies that can improve quality of life, necessitate the need to understand the biology of addiction for possible identification of drug targets in the brain circuit and conduct large-scale clinical studies with the hope of finding efficacious and safe medicines. Because of the wide projections of orexinergic neurons and their complicated linkage with other neurons along with the diffused distribution of orexin receptors, the orexin system is involved in the regulation of multiple central nervous system functions including addiction. Rigorous studies on the molecular and cellular bases are highly important emphasizing on how the orexinergic system is interacting with addictive substances and can modify the brain reward circuit. Therefore, the aim of this review is to discuss the existing knowledge and evidence on orexin’s cellular connectivity with addiction-related brain structure and the emerging role of orexinergic system in the treatment of addiction.
The Correlation of Susceptibility to CdCl2 with the Level of ROS in the Photosynthetic Euglena gracilis Strain Z and Nonphotosynthetic SMZ

Field: Agricultural and Biological Sciences (Life Sciences)

We have shown that the photosynthetic strain Z of Euglena gracilis is more susceptible to cadmium chloride (Cd) than the non photosynthetic strain SMZ. We here investigated the correlation of the intracellular ROS level with the Cd-induced cellular damages. Flow cytometry using a probe for ROS showed that strain Z had higher levels of ROS than strain SMZ, and that this difference between the two strains is enhanced following the Cd exposure. The level of ROS increased at the cytotoxic concentrations of Cd; over 10 muM for Z and 50 muM for SMZ. These suggest an association of Cd cytotoxicity with ROS generation. Considering the absence of photosynthetic electron flows in SMZ, higher levels of ROS in strain Z might be due to blockade of electron flows by Cd in photosynthesis.
Learning: Javanese Students, Non-Javanese Students

Field: Social Sciences (Social Sciences)

Learning is an important activity that must be done by students. If you want to know a course material or information, of course, students must look for it. One of the ways to look for something is by learning. Students at Kanjuruhan University come from various regions in Indonesia. The researcher divided the students into two large groups, namely students from Java and Non-Java. Both have unique and different ways to absorb information. Their learning methods are affected by the background of their respective regions. Each lecturer should know the background of each student, especially about the origin of the region. The results of this study indicate that lecturers are better of using a descriptive approach when explaining material to Javanese students. Meanwhile, when lecturers explain the material to students non-Java it is better to use a prescriptive approach. In this way the lecturer will find it easier to explain the lecture material that will be delivered. In addition, students will also have no difficulty in absorbing lecture material delivered. Keywords: Prescriptive, Descriptive, Javanese Students, Non-Javanese students
Bisphosphonates and Nephrocalcinosis in a Rabbit Leg Lengthening Model: A Histological and Therapeutic Comparison

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract: We performed a comparison of the effects of two bisphosphonates, pamidronate and zoledronic acid, on regenerate bone mineral content in distraction osteogenesis in an immature rabbit model. Single dose zoledronic acid was found to be 18 times more potent at producing an increase in bone mineral content than pamidronate per mg/kg of drug infused at surgery. Histological examination of all rabbit kidneys was performed at trial completion. Nephrocalcinosis was identified in 14 of 20 kidneys of rabbits infused with pamidronate, but was not detected in the 20 kidneys of those rabbits infused with zoledronic acid. A further 20 kidneys from rabbits given a second dose of zoledronic acid were also found to be free of signs of nephrocalcinosis. Three of 40 control kidneys exhibited signs of nephrocalcinosis. The increased potency of zoledronic acid allowed us to give one‐tenth the dose of pamidronate, with increased therapeutic efficacy and no evidence of nephrocalcinosis.
Relationship between mental health diagnoses and sexually transmitted infections

Field: Medicine (Health Sciences)

Multiple studies have demonstrated a relationship between risk factors for sexually transmitted infections (STIs) and mental health needs. This “syndemic” phenomenon suggests that while many patients with mental health conditions are at higher risk for STI acquisition, the relationship also works in the opposite direction: Patients diagnosed with STIs are more likely to have mental health issues. The purposes of this review article are to examine the overlap between mental health and STIs, to provide mental health providers the tools to identify individuals with behavioral health concerns who may be at increased risk for STI acquisition, to discuss how STI diagnosis can affect mental health, and to review interventions to mitigate these risks, such as cognitive-behavioral therapy and motivational interviewing-based behavioral interventions. Integrating primary health care and mental health care for sexual health needs may also help improve delivery of both of these services.
SPACE-STRUCTURED MODEL WITHIN THE COMIC EFFECT ANALYSIS: COGNITIVE AND DISCURSIVE ASPECT

Field: Arts and Humanities (Social Sciences)

The study shows how space-structured model can be applied in the analysis of comic elements verbalisators in a sense construction. The stages of creative comic sense derivation are specified: physicalization, direct hypostasis and re-objectivative hypostasis. The concept of lexical expectation serves the basis for transformed sense modelling that realizes comic effects. Creative aspects of individual concept-valency system are constantly revised as regards their compliance with general linguoculture system in order to provide adequate interpretation of comic elements by counter communicants.