jimnoneill/paper-to-field-training huggingface dataset:
Abstract B006: Large scale microarray profiling reveals four stages of immune escape in Non Hodgkin lymphomas

Field: Medicine (Health Sciences)

Abstract Non-Hodgkin B-cell lymphoma (B-NHL) are aggressive lymphoid malignancies that develop in patients due to oncogenic activation, chemo-resistance and immune evasion. Tumor biopsies show that B-NHL frequently use several immune escape strategies, which has hindered the development of checkpoint blockade immunotherapies in these diseases. To gain a better understanding of B-NHL immune editing, we hypothesized that the transcriptional hallmarks of immune escape associated with these diseases could be identified from the meta-analysis of large series of microarrays from B-NHL biopsies. Thus, 1446 transcriptome microarrays from seven types of B-NHL were downloaded and assembled from 33 public Gene Expression Omnibus (GEO) datasets, and a method for scoring the transcriptional hallmarks in single samples was developed. This approach was validated by matching scores to phenotypic hallmarks of B-NHL such as proliferation, signaling, metabolic activity and leucocyte infiltration. Through this method, we observed a significant enrichment of 33 immune escape genes in most diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) samples, with fewer in mantle cell lymphoma (MCL) and marginal zone lymphoma (MZL) samples. Comparing these gene expression patterns with overall survival data evidenced four stages of cancer immune editing in B-NHL: non-immunogenic tumors (stage 1), immunogenic tumors without immune escape (stage 2), immunogenic tumors with immune escape (stage 3), and fully immuno-edited tumors (stage 4). This model complements the standard international prognostic indices for B-NHL and proposes that immune escape stages 3 and 4 (76% of the FL and DLBCL samples in this dataset) identify patients relevant for checkpoint blockade immunotherapies. Note: This abstract was not presented at the conference. Citation Format: Jean-Jacques Fournie. Large scale microarray profiling reveals four stages of immune escape in Non Hodgkin lymphomas [abstract]. In: Proceedings of the Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; 2016 Sept 25-28; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(11 Suppl):Abstract nr B006.
Stamps Don’t Lie: Sports, Military, and National Identity Postage Stamps As a Mirror of Aggressive Soviet and Russian Propaganda

Field: Social Sciences (Social Sciences)

Abstract During the 20 th century, authoritarian regimes willingly embraced sport as a vivid arena for demonstrating their superiority. Prior research on postage stamps issued by such regimes revealed certain patterns associated with periods of aggressive internal and external rhetoric, whereby postage stamps served as a channel for government propaganda. In the current study, we looked at sports, military, and national identity stamps. Applying the social-semiotic method, we first examined the messages sports stamps have conveyed in Soviet Union and Russia. Then, the quantitative paradigm was employed to evaluate the trends in the issuance of propagandistic stamps by post-WW2 USSR and Russia. Finally, we expanded the scope by looking at stamp issuance in Germany, Italy, and USSR in pre-WW2 and WW2 years. This heavily militaristic “landscape” was used mainly as a basis for comparison with the issuance policy of Putin’s Russia. The results shed light on some striking similarities across the different countries and periods. These findings are discussed in the context of the recent geopolitical situation.
DELAYED CHOICE RESPONDING BY PIGEONS WHEN THE CORRECT RESPONSE IS NOT PREDICTABLE FROM THE SAMPLE STIMULUS

Field: Neuroscience (Life Sciences)

Food‐deprived pigeons were presented with a row of four response keys situated above a grain hopper aperture. At the start of a trial, three of four keys were randomly selected and illuminated white for six seconds. After a variable blackout period, one of the three previously white keys and the previously dark key were illuminated green, and the remaining white keys were reilluminated as before. A response to the green key that was previously white was reinforced with three‐seconds access to grain; a response to any other key resulted in a three‐second blackout and the start of a new trial. Five of six subjects responded to the correct green key more often than chance at an interstimulus interval of 1.5 seconds, and they displayed maximal performance at different intertrial interval values ranging from 15 to 60 seconds. Choice accuracy decreased for all but one subject as the interstimulus interval was increased. For the range of interstimulus interval durations employed, decrements in choice accuracy were qualitatively similar to, but lower than those typically obtained from, delayed‐matching‐to‐sample or delayed‐pair comparison procedures.
Role Inversion: The Curator Takes the Stage

Field: Arts and Humanities (Social Sciences)

January 01 2014 Role Inversion: The Curator Takes the Stage Bertie Ferdman Bertie Ferdman Bertie Ferdman's research specialties are in contemporary performance, site-based art practices, and urban theatre. She is currently working on a project that documents international curatorial models that exemplify new trends in presenting live art practice. She is assistant professor in the department of speech, communications, and theatre arts at Borough Manhattan Community College, CUNY. Search for other works by this author on: This Site Google Scholar Author and Article Information Bertie Ferdman Bertie Ferdman's research specialties are in contemporary performance, site-based art practices, and urban theatre. She is currently working on a project that documents international curatorial models that exemplify new trends in presenting live art practice. She is assistant professor in the department of speech, communications, and theatre arts at Borough Manhattan Community College, CUNY. Online ISSN: 1537-9477 Print ISSN: 1520-281X © 2014 Bertie Ferdman2014 PAJ: A Journal of Performance and Art (2014) 36 (1 (106)): 53–58. https://doi.org/10.1162/PAJJ_a_00176 Cite Icon Cite Permissions Share Icon Share Facebook Twitter LinkedIn Email Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation Bertie Ferdman; Role Inversion: The Curator Takes the Stage. PAJ: A Journal of Performance and Art 2014; 36 (1 (106)): 53–58. doi: https://doi.org/10.1162/PAJJ_a_00176 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPAJ: A Journal of Performance and Art Search Advanced Search This content is only available as a PDF. © 2014 Bertie Ferdman2014 Article PDF first page preview Close Modal You do not currently have access to this content.
Effect of Vitamin D Supplements On Hemoglobin Concentration in Patients with Iron Deficiency Anemia and Concurrent Vitamin D Deficiency:A Randomized Single Blind Placebo Controlled Trial

Field: Medicine (Health Sciences)

Abstract Abstract 5173 Background: The effect of vitamin D replacement on hemoglobin concentration in subjects with concurrent iron deficiency anemia and vitamin D deficiency is not known. Methods: In a single blinded randomized placebo controlled study, thirty subjects with iron deficiency anemia (serum ferritin < 15 ug/dl) were randomized to intervention arm (vitamin D 6 lakh IU IM once) or placebo. In all subjects, iron deficiency was corrected with parental iron. All the causes other than iron deficiency were excluded with appropriate investigation. The primary end point was rise in hemoglobin concentration. Results: Baseline age, BMI, hemogram, levels of serum ferritin, 25(OH)D and PTH were similar in both the arms. Twelve weeks after vitamin D replacement, there was significant increase in 25 (OH) D levels and decrease in PTH levels in subjects with intervention arm compared to placebo arm (p<0. 01). The increment in serum ferritin in both the group was similar. There was no further increase in hemoglobin concentration in intervention arm compared to placebo arm. Conclusion: Vitamin D replacement in subjects with iron deficiency anemia after iron correction does not improve hemoglobin concentration further. Disclosures: No relevant conflicts of interest to declare.
The reorganization of model membranes by Gb3-binding lectins and the bacterium Pseudomonas aeruginosa

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

L'interaction des glycosphingolipides de la membrane plasmique avec les protéines de liaison aux glucides (lectines) est d'une importance vitale pour l'infection de la cellule hôte par divers virus et bactéries. Dans ce travail, nous avons exploré l’interaction des lectines LecA de la bactérie P. aeruginosa et de la sous-unité B de la toxine Shiga (StxB) de S. dysenteriae avec son récepteur à membrane plasmatique, le globotriaosylcéramide (Gb3). De plus, nous avons étudié l'interaction de la bactérie complète P. aeruginosa avec Gb3. Afin de déchiffrer l'interaction lectine-Gb3 en l'absence d'autres composants cellulaires, nous avons utilisé les systèmes de membrane artificielle - vésicules unilamellaires géantes (GUV) et bicouches lipidiques supportées (SLB). Nous avons observé la liaison de la lectine en utilisant différents modes de microscopie à fluorescence (confocal, TIRF, etc.). Nous examinons la liaison des deux lectines aux domaines membranaires de différents ordres et compositions. Nous avons constaté que StxB préfère des domaines membranaires plus ordonnés alors que LecA est moins préférentiel. De plus, les deux lectines induisent la réorganisation des domaines membranaires: StxB stabilise les domaines ordonnés, les réduit et induit la formation des nouveaux domaines ordonnés. D'autre part, LecA ainsi que la bactérie P. aeruginosa induisent la dissolution des domaines ordonnés. Nous pensons que ces processus de réorganisation membranaire sont cruciaux pour l’infection bactérienne.
Introduction

Field: Social Sciences (Social Sciences)

This chapter introduces issues and arguments addressed in this book. The issues can be flagged only by explaining political and economic background that the agrarian sector has witnessed in independent India. Issues of accessibility, affordability, and availability of basic raw materials and seeds and varieties of farmers became prominent after international intellectual property regime attributed rights over plant genetic resources to breeders. Withdrawal of the state coupled with commercialization of seeds and varieties at the hands of multinational companies has posed serious threat to Indian farmers. These are explained at the backdrop of discussions on the political economy of seeds and varieties during the period of transition from planned economic development to liberalization. International conventions and their impact on Indian policy regime has been explained to analyse the influence of international trade lobby in regulating Indian agrarian sector.
Synergism Between the Spleen and Serum Complement in Experimental Pneumococcemia

Field: Medicine (Health Sciences)

To examine the interplay between the spleen and complement activation in host defense against pneumococcemia, serial colony counts in blood and survival rates were studied after high-dose (10(5)) and low-dose (10(2)) intravenous challenge with growth-phase Streptococcus pneumoniae type 3 in rats with splenic remnants of varying size (partial, total, or no splenic resection) and with or without complement depletion (by pretreatment with cobra venom factor [CVF]). After high-dose challenge, the combination of total splenectomy and CVF produced greater pneumococcemia and higher mortality than either factor alone. After low-dose challenge, survival was uniform except when CVF was coupled with total splenectomy or splenic remnants less than one third of normal size, combinations which resulted in extremely high early mortality. This synergistic interaction between total splenectomy and CVF reveals a serious postsplenectomy immune defect and provides a highly sensitive assay of residual protective function in the spleen.
The Concept of Green Human Resource Management in Industry

Field: Business, Management and Accounting (Social Sciences)

The integration of environmental management into Human Resource Management (HRM) is called Green HRM. There is a growing need for the application of Green HRD in industry. The objective of this review is to explore green human resource management practices of organizations in the industry based on the existing literature. Based on this review, it is concluded that by understanding and increasing the scope and depth of green HRM practices, organizations can improve their environmental performance in a more sustainable manner than before. The green HRM practices are more powerful tools in making organizations and their operations in industry green. The green performance, green behaviors, green attitude, and green competencies of human resources can be shaped and reshaped through the adaptation of green HRM practices.
Multi-beam spatially multiplexed interference microscopy for phase objects examination

Field: Physics and Astronomy (Physical Sciences)

Multi-beam Spatially Multiplexed Interferometric Microscopy (MB-SMIM) is presented as the implementation of a robust, fast and accurate single-shot phase-estimation algorithm with a simple, low-cost and stable way to convert a bright-field microscope into a holographic one using partially-coherent illumination. Ronchi diffraction grating is used to generate two-beam and multi-beam interference. To ensure effectiveness of the process object field should be divided into analyzed specimen area (1/3) and clear reference area (other 2/3). Using partially coherent light source one is able to produce pure three-beam interference of -1 diffraction order of specimen area, and 0/+1 diffraction orders of both clear reference areas. Opposite sign orders create doubled spatial frequency term overlapping with the regular SMIM interferogram. Phase demodulation based on the single-frame two-dimensional Hilbert-Huang transform or regular multi-frame phase-shifting follows. Single-frame processing is more beneficial for increased spatial frequency term when doubled number of fringes "samples" the same phase variation as in regular SMIM interferogram. Adding (or subtracting) two three-beam interferograms phase shifted by π allows one to accurately isolate doubled (or single) spatial frequency fringe pattern. Altogether, MB-SMIM adds quantitative phase imaging capability to a commercially available non-holographic microscope with improved phase reconstruction: noise reduction, spatial frequency doubling and phase change disambiguation capabilities. Proposed method enables common-path optical generation of doubled spatial frequency fringes only by slight object field manipulation – no mechanical doubling of incident angle is needed. The technique has been validated using a 20X/0.46NA objective in Olympus BX-60 upright microscope for prostate cancer cells phase imaging.
Subacute Cardiotoxicity\nof Yessotoxin: <i>In\nVitro</i> and <i>in Vivo</i> Studies

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Yessotoxin (YTX) is a marine phycotoxin\nproduced by dinoflagellates\nand accumulated in filter feeding shellfish. Although no human intoxication\nepisodes have been reported, YTX content in shellfish is regulated\nby many food safety authorities due to their worldwide distribution.\nYTXs have been related to ultrastructural heart damage <i>in\nvivo</i>, but the functional consequences in the long term have\nnot been evaluated. In this study, we explored the accumulative cardiotoxic\npotential of YTX <i>in vitro</i> and <i>in vivo</i>. Preliminary <i>in vitro</i> evaluation of cardiotoxicity\nwas based on the effect on hERG (human ether-a-go-go related gene)\nchannel trafficking. <i>In vivo</i> experiments were performed\nin rats that received repeated administrations of YTX followed by\nrecordings of electrocardiograms, arterial blood pressure, plasmatic\ncardiac biomarkers, and analysis of myocardium structure and ultrastructure.\nOur results showed that an exposure to 100 nM YTX for 12 or 24 h caused\nan increase of extracellular surface hERG channels. Furthermore, remarkable\nbradycardia and hypotension, structural heart alterations, and increased\nplasma levels of tissue inhibitor of metalloproteinases-1 were observed\nin rats after four intraperitoneal injections of YTX at doses of 50\nor 70 μg/kg that were administered every 4 days along a period\nof 15 days. Therefore, and for the first time, YTX-induced subacute\ncardiotoxicity is supported by evidence of cardiovascular function\nalterations related to its repeated administration. Considering international\ncriteria for marine toxin risk estimation and that the regulatory\nlimit for YTX has been recently raised in many countries, YTX cardiotoxicity\nmight pose a health risk to humans and especially to people with previous\ncardiovascular risk.
Does socioeconomic status modify the effect of air pollution on birth outcomes?

Field: Medicine (Health Sciences)

BACKGROUND: Several studies have examined whether air pollution is associated to adverse births outcomes but it is not clear if socioeconomic status (SES) modifies this relationship. OBJECTIVES: We investigated if individual and area-level socioeconomic status modified the relationship between ozone, nitrogen dioxide and particulate matter with aerodynamic diameter <10µm (PM10) and preterm deliveries (gestational age <37 weeks) and term low birth weight (TLBW; < 2500g). METHODS: Analyses were based on almost 1 million singleton live births in São Paulo municipality between 2011 and 2016. Exposure to PM10, NO2 and O3 were estimated by average trimestral and entire gestation based on date of birth and using daily averages of air pollution from the network of monitoring stations. Multilevel logistic regression models were conducted to examine the effect of air pollutants on both birth outcomes and whether it was modified by SES. RESULTS: In fully adjusted models, over the entire pregnancy, a 10µg/m³ increase in O3 and PM10 was associated to PTD (odds ratio; OR = 1.14 CI 1.13,1.16 and 1.08 CI = 1.02,1.15 respectively) and PM10 was associated to TLBW (OR = 1.08 CI 1.03, 1.14). Associations were modified by individual and area-level SES for both outcomes (p<0,001). Mothers with low individual SES had an additional risk for PTD and TLBW associated with PM10 exposure (OR = 1.04 CI 1.04,1.05 and 1.10 CI 1.08,1.14 respectively). Lower area-level SES also implied in a stronger risk for TLBW (OR = 1.05 CI 1.03,1.06). Similar effect modifications were observed for O3 exposure. Trimester specific associations were weaker but followed a similar pattern. CONCLUSION: Individual and neighborhood socioeconomic status modifies the effect of air pollution on adverse birth outcomes. Mothers with lower SES may be more susceptible to adverse pregnancy outcomes associated with air pollution exposure.
Adaptation trail of selected Multipurpose Tree Species under Babille Condition East Hararghe Zone oromia, Ethiopia

Field: Agricultural and Biological Sciences (Life Sciences)

Among several multipurpose tree species in the eastern parts of Ethiopia, Sesbania sesban, Moringa oliefera, Gravilea robusta, Cordia africna, Azadarichta indica and Leuceana leucocephala are common. However, their adaptability and growth performance of this tree species has not scientifically trailed in the study area. Therefore, the study was conducted to evaluate the adaptability of multipurpose tree species at Babille District, Oromia, Ethiopia, for three years (June 2016 - June 2019). The experiment was laid out in RCBD with three replications. Data on the growth parameters; diameter, plant height and survival rate were measured and recorded at interval of three months. Results revealed that there were highly significant (p <0.05) variations among tree species in height growth, RCD, DBH and survival rate at the study area. Among the species tasted, M. oliefera showed the highest performance followed by A. indica, S. sesban and L. leucocephala in terms of height growth, RCD and DBH at Babille condition. after three years of establishment, M. oliefera, A. indica, S. sesban and L. leucocephala showed the highest mean survival rate at the study area. Hence it can be inferred that the conditions of Babille district matched with the environmental requirement of those tree species. On the other hand, species of G. robusta showed lowest performance at the study area. Thus, the long dry season, which extended from eight to ten months in the study area, clearly explains the poor survival and growth response in some of the species. Generally, the study under Babille condition and related agro-ecology, we advocate these adapted species and properly allocate species into the site that grow and adapt well for further agroforestry practices at wider scale on which success of agroforestry practices and forest plantations depend.
INFLUENCE OF PLANT GROWTH REGULATORS ON SEEDLINGS MORPHOGENESIS AND LABORATORY SEED GERMINATION OF WINTER PEA OF VARIETY NS MOROZ

Field: Agricultural and Biological Sciences (Life Sciences)

The introduction of winter pea into the agricultural production is a priority direct of the plant growing because of a several advantages of winter pea over the spring pea: regular harvest of grain and green mass; protection of soil from wind and water erosion; effective use of moderate temperatures and humidity of late autumn and early spring periods. The purpose of our work was to show the results of studies of the influence of growth regulators on the laboratory seed germination and morphometric parameters of seedlings of winter pea. The studies were conducted on the culture of winter pea of variety NS Moroz. Presowing treatment of pea seeds was performed with aqueous solutions of Gumifild (0,2 %) and Endophyt-L1 (0,2 %), and with water in the control. In the process of research, the germination energy and laboratory germination of seeds, the linear sizes of the hypocotyl and the main root of the seedlings, the dry mass of seedlings and roots were determined. It was established that preparations Endophyt-L1 and Gumifild increased the laboratory germination of the seed and germination energy. Under the influence of the drug Endophyt-L1 germination energy increased by 12 % and laboratory germination of seeds – by 8 %. The application of Gumifild was more efficient, because the germination energy in this experimental variant increased by 16 % and the general germination of seeds – by 11 %. The number of normally developed seedlings (with a length of 0,5-1,0 cm) in the variant with the using of Endophyt-L1 was 42,8, with the using of Gumifild – 46. There were 36,2 seedlings in control. It was established that the use of the drugs of stimulating action has led to changes in the morphogenesis of seedlings of winter pea culture. The preparations caused the lengthening of the hypocotyl and the main root of the young plants. Growth regulators increased the damp weight of hypocotyls and roots of the winter pea seedlings. The best effect was found in the pre-sowing treatment of seeds with Gumifild (0,2 %). When comparing the two used preparations, it should be noted that the application of the natural plant growth stimulator Gumifild on the seeds of winter pea of variety of NS Moroz was more effective than the using of the broad-spectrum plant growth stimulator Endophyt-L1. The search of the ways to increase the level of productivity of winter peas aimed at the study of technology of cultivation of Frost variety with the introduction of new methods and the use of plant growth regulators with different mechanisms of action and inoculation by symbiotic bacteria.