jimnoneill/paper-to-field-training huggingface dataset:
Use of a Low-Prime Circuit for Bloodless Heart Transplantation in Xenotransplant of 5—7 Kilogram Primates

Field: Medicine (Health Sciences)

There is a great effort to decrease blood product use during open-heart surgery in pediatrics. We were presented with a research challenge to accomplish heart xenotransplantation from donor cynomologous monkey ( Macaca fascicularis ) to recipient olive baboon ( Papio anubis ) of 5–7 kilograms without benefit of donor or banked blood products. The purpose of this study was to design and implement a practical, low-volume circuit to minimize hemodilution and avoid the use of blood products. A simple circuit was assembled using a low-volume oxygenator with hardshell venous reservoir, an 1/8-inch arterial line, an 1/4-inch venous line, and gravity drainage. Three xenotransplants were performed and evaluated. The mean recipient weights were 6.3 ± 0.7 kg. Circuit prime volume was 228 ± 5.8 mL, and bypass time was 85 ± 6.7 min. Blood flow rates were 585 ± 113 mL/min with postmembrane arterial line pressures of 344 ± 81 mmHg, and patient mean arterial pressures (MAP) of 51.4 ± 16.7 mmHg. Venous saturations were 63.7 ± 8.0%. The hematocrit prebypass was 37.4 ± 3.2, bypass 20.7 ± 0.9, post-MUF 27.8 ± 3.3, and 7 days postoperative 24.5 ± 7.5%. Platelet count was 289 ± 1.1 K/µL, 147 ± 37.1 K/µL, and 322 ± 292.7 K/µL prebypass, postbypass, and 7 days postoperative, respectively. Plasma-free hemoglobin prebypass was 7.5 ± 4.4 mg/dL and postbypass 22.2 ± 16.5 mg/dL with no noted hematuria during and after the procedure. All patients survived and were successfully weaned from cardiopulmonary bypass (CPB) with same day extubation. A low-prime circuit for bloodless heart surgery is possible. To achieve low reservoir levels, especially without the use of an arterial line filter (ALF), it is necessary to have a full armament of monitoring and alarm devices.
Additional file 1 of Co-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Additional file1: Figure S1. Expression level changes during cardiomyocyte differentiation. A Heatmap of expression levels during cardiomyocytes differentiation. B Heatmap of expression levels of some key factors during cardiomyocytes differentiation. Figure S2. GO enrichment analysis results of genes under different clusters in Figure 2A. Figure S3. Correlation between gene m6A levels and expression levels. A Dot plot show a weak negative correlation between gene m6A levels and expression levels during differentiation. B Comparison of gene expression levels among different m6A levels. Genes were categorized into three groups based on their m6A levels: low (m6A level < 1.5), medium (1.5 < m6A level < 4), and high (m6A level > 4). ** represents p-value<0.01. Figure S4. Correlation analysis between the expression of potential target genes associated with cardiomyocyte differentiation (regulated by METTL14, RBM15, and ALKBH5) and the expression levels of m6A readers. The correlation was assessed using the Pearson correlation coefficient. Figure S5. A The correlation between reader expression and m6A does not affect the accessibility of the corresponding gene. B The reader responds differently to genes with different degrees of accessibility. neg/not/pos cor: genes whose m6A levels or accessibility are negatively/not/positively correlated with the expression of m6A-related readers. Figure S6. Comparison of binding levels of key transcription factors with different m6A level in D0 and D15. A Binding levels of key transcription factors in stem cells. B Binding levels of key transcription factors in cardiomyocytes. Genes were categorized into three groups based on their m6A levels: low (m6A level < 1.5), medium (1.5 < m6A level < 4), and high (m6A level > 4). * represents p-value<0.05, Wilcoxon test. Figure S7. GO enrichment analysis results of genes under four groups base on their m6A level and accessibility changes: A genes with discordant changes, B genes with concordant changes, C genes with only m6A changes, and D genes with only accessibility changes
Significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, serum albumin and prognostic nutritional index as predictors of morbidity in super-elderly patients operated on for acute appendicitis.

Field: Medicine (Health Sciences)

The present study found that PNI and albumin values can be used as prognostic factors and have high sensitivity and specificity. Therefore, this study is a leader study in identifying prognostic factors for AA that can be used in the super-elderly geriatric population. However, the possibility of statistical error should be minimized by conducting studies involving more patients.
Hepatoprotective effect of Chichorium intybus L. on liver toxicity in rat

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Background: Plant phenolic compounds such as flavonoids have important role in treatment of many diseases. Also some of them have potent hepatoprotective effects. Objective: In this study, we have investigated the protective effects of polyphenolic extracts of Silybum marianum and Chichorium intybus on thioacethamide-induced hepatotoxicity in rat. Methods: Extracts were injected to rats, at a dose of 25 mg/kg body weight together with thioacetamide at a dose of 50 mg/kg body weight. For investigation of the hepatoprotective effect of extracts against thioacetamide, activity of aminotransferases (SGOT and SGPT), alkalin phosphatase, bilyrubin, Na+ and K+ were measured. Results: significant decreases were observed in activities of aminotransferases, alkalin phosphatase and bilyrubin in groups that treated with extracts together with thioacetamide in comparation with thioacetamide treated group. Level of Na+,K+ and liver weight betwen different groups had not significant different. Conclusions: This results showed protective effect of chichorium extracts on thioacetamide-induced hepatotoxicity in rat.
Feminism’s Archives

Field: Arts and Humanities (Social Sciences)

Archival practice and recovery have been foundational to feminist criticism and theory, and continue to be advocated by those who perceive, with dissatisfaction, ongoing gender disparities within the broadly inclusive mandate of the new modernist studies. Starting with the supposition that taxonomy is somatic, this chapter explores the long, complex history of the categorised body in relation to the archives of Mina Loy and Anna Mendelssohn. Modernist and late modernist respectively, Loy and Mendelssohn were British, Jewish, and feminist; both worked productively from the margins of male avant-garde kinship groups. Excision from or discomfort with identificatory labels are abiding themes of their literature, truths highly evident in their conflicted, archived writings on artistry and parenting, which challenge and contort stereotypical classification. In tandem with Loy’s and Mendelssohn’s taxonomic ambivalence, this essay posits a generative interstitiality that reworks archival frameworks and categories alike.
Shakespeare and Religion

Field: Arts and Humanities (Social Sciences)

This book sets Shakespeare in the religious context of his times, presenting a balanced, up-to-date account of current biographical and critical debates, and addressing the fascinating, under-studied topic of how Shakespeare's writing was perceived by literary contemporaries - both Catholic and Protestant - whose priorities were more obviously religious than his own. It advances new readings of several plays, especially Hamlet, King Lear and The Winter's Tale; these draw in many cases on new and under-exploited contemporary analogues, ranging from conversion narratives, books of devotion and polemical pamphlets to manuscript drama and emblems. Shakespeare's writing has been seen both as profoundly religious, giving everyday human life a sacramental quality, and as profoundly secular, foreshadowing the kind of humanism that sees no necessity for God. This study attempts to reconcile these two points of view, describing a writer whose language is saturated in religious discourse and whose dramaturgy is highly attentive to religious precedent, but whose invariable practice is to subordinate religious matter to the particular aesthetic demands of the work in hand. For Shakespeare, as for few of his contemporaries, the Judaeo-Christian story is something less than a master narrative.
A Dispositional Theory of Health

Field: Arts and Humanities (Social Sciences)

A satisfactory account of the nature of health is important for a wide range of theoretical and practical reasons. No theory offered in the literature thus far has been able to meet all the desiderata for an adequate theory of health. This article introduces a new theory of health, according to which health is best defined in terms of dispositions at the level of the organism as a whole. After outlining the main features of the account and providing formal definitions of ‘health’, ‘healthy’, and ‘healthier than’, I present the main strengths of the proposed account. I argue that the proposed dispositional theory accounts for all paradigm cases of health and pathology, that it circumvents a number of problems faced by rival theories, and that it makes for a naturalistic theory of health with a rigorous metaphysical underpinning.
Tissue Angiotensinogen Gene Expression Induced by Lipopolysaccharide in Hypertensive Rats

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract There is now convincing evidence that various tissues express their own tissue renin-angiotensin system, which may be regulated independently of the systemic renin-angiotensin system. However, little information is available on the regulation of the tissue renin-angiotensin system. We investigated the regulation of tissue angiotensinogen gene expression with respect to the development of hypertension. We measured basal and lipopolysaccharide-stimulated plasma angiotensinogen concentrations by radioimmunoassay and examined the expression of tissue angiotensinogen by Northern blot analysis in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) at 4 and 13 weeks of age. Basal plasma angiotensinogen concentration in SHR was comparable to that in WKY at 4 weeks of age and was significantly higher than that in WKY at 13 weeks of age. Lipopolysaccharide induced a significant increase in plasma angiotensinogen concentration in both WKY and SHR at 4 and 13 weeks of age. At 4 weeks of age, the basal levels of angiotensinogen mRNA in the liver, fat, adrenal, and aorta were higher in WKY than in SHR. At 13 weeks of age, the basal levels of angiotensinogen mRNA in the fat, adrenal, aorta, spleen, and kidney were higher in WKY than in SHR, while that in the liver did not differ significantly between the two strains. At 4 weeks of age, pretreatment with lipopolysaccharide increased the angiotensinogen mRNA levels in the liver, fat, adrenal, and aorta in both WKY and SHR. At 13 weeks of age, pretreatment with lipopolysaccharide increased the angiotensinogen mRNA levels in the liver, aorta, and adrenal; decreased those in the spleen; and had no effect in the kidney in both WKY and SHR. Interestingly, lipopolysaccharide increased the angiotensinogen mRNA level in fat only in SHR, with no effect in WKY, at 13 weeks of age. Lipopolysaccharide stimulated tumor necrosis factor-α mRNA expression in fat of WKY and SHR, and the increase in tumor necrosis factor-α mRNA level in SHR was significantly greater than that in WKY. Therefore, the increased tumor necrosis factor-α mRNA expression may be involved in the increased lipopolysaccharide-induced expression of angiotensinogen gene in fat of SHR at 13 weeks of age. These data suggest that the transcriptional and probably posttranscriptional regulation of angiotensinogen mRNA differs between SHR and WKY, that the regulation of angiotensinogen gene expression is tissue-specific, and that the altered expression of the angiotensinogen gene may be involved in the development of hypertension.
Les Annonciations de Fra Angelico, Pollaiuolo, Piero della Francesca et Robert Campin : questions d’ornementalité et de couleur

Field: Arts and Humanities (Social Sciences)

The Annunciations by Fra Angelico, Pollaiuolo, Piero della Francesca and Robert Campin : Issues of Ornamentality and Colour. This study focuses on Tuscan Annunciations, with the addition of one from Umbria, created between the 1420s and the 1470s by, among others, Fra Angelico, the Pollaiuolo brothers, Piero della Francesca, Filippo and Filippino Lippi. It seeks to demonstrate that these painters used a high degree of ornamentality in order to embody the presence of the divine on earth. Indeed, ornamentality was intrinsically linked to the idea of beauty, itself an attribute of God and a heavenly trait. This essay examines in particular the abstract and multicolored mineral surfaces of the walls of Mary's house, which becomes the house of God at the Incarnation. This is followed by the temporary presence on earth of Gabriel, as the celestial being appears before Mary. The archangel's wings are the focus of careful analysis as they sometimes convey theological discourses expressed through chromatic.
Expression, Purification of Human Endostatin in Pichia pastoris and the Detection of Its Anti-angiogenic Activity

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Endostatin is a potent, endogenous inhibitor of angiogenesis, which corresponds to the C-terminal fragment of collagen ⅩⅧ. The human endostatin gene was amplified from a human fetal liver cDNA library by means of PCR and was cloned into pPIC9K vector. Soluble endostatin was superexpressed in Pichia pastoris (50.5mg/L) . The recombinant protein was purified by cation exchange chromatography with the final yield of more than 95%. Western blotting analysis showed positive immunoreactivity to the expressed product. Recombinant endostatin was able to suppress the angiogenesis on the CAMs. Also, the endostatin inhibited specifically of the migration of HMECs stimulated by bFGF, with EC50 being about 0.4 μg/ml.
Uncertainty considerations on the new Avogadro sphere interferometer

Field: Physics and Astronomy (Physical Sciences)

For the aim of redefining the SI unit kilogram basing on the Avogadro constant N A the International Avogadro Coordination has to achieve an overall relative measurement uncertainty less than 2×10 -8 . The most contributing part with 1×10 -8 to this originates from the interferometric volume determination of the Si 28 spheres. And here the dominant uncertainty results from the deviations of the optical system from perfection. At the present state the influence of these wavefront aberrations is only based on a careful estimation. For a distinct knowledge of the influence of surface deviations and adjustment errors a ray tracing routine and evaluation procedures were implemented.
A Comparative Study of Survivor Outcomes between Preoperative Evaluation Using CT Alone and Combined CT and MRI in Patients with Pancreatic Ductal Adenocarcinoma

Field: Medicine (Health Sciences)

There were no significant differences in the recurrence pattern, DFS, or OS between patients evaluated with preoperative CT alone or with CT and MRI after curative resection of PDAC. Liver metastasis was the most common tumor recurrence pattern with the lowest OS.
Evaluation of Various Local Rice Genotypes in the Mandailing Natal Province of North Sumatra

Field: Agricultural and Biological Sciences (Life Sciences)

The purpose of this study was to evaluation of several local rice genotypes in the Mandailing Natal Province of North Sumatra. This studay was and has been conducted from April 2017 to October 2017. Data observed in the form of quantitative data and qualitative data of local rice plants. The results showed that rice cultivars were found in various regions in Mandailing Natal District with a high variety of characteristics. Sampling was done by purposive sampling from 23 subdistricts in Mandailing Natal District. Data observed in the form of quantitative data and qualitative data of local rice plants. The results showed that rice cultivars were found in various regions in Mandailing Natal District with a high variety of characteristics. The sigudang genotype was the best genotype with a total grain weight of 82.6 grams. Genotype Sisorang have a good agronomic appearance. Keywords— Local rice plants, Germplasm, Characterization, exploration.
Time Synchronized Velocity Error for Trajectory Compression

Field: Computer Science (Physical Sciences)

Nowadays, distance is usually used to evaluate the error of trajectory compression. These methods can effectively indicate the level of geometric similarity between the compressed and the raw trajectory, but it ignores the velocity error in the compression. To fill the gap of these methods, assuming the velocity changes linearly, a mathematical model called SVE (Time Synchronized Velocity Error) for evaluating compression error is designed, which can evaluate the velocity error effectively, conveniently and accurately. Based on this model, an innovative algorithm called SW-MSVE (Minimum Time Synchronized Velocity Error Based on Sliding Window) is proposed, which can minimize the velocity error in trajectory compression under the premise of local optimization. Two elaborate experiments are designed to demonstrate the advancements of the SVE and the SW-MSVE respectively. In the first experiment, we use the PED, the SED and the SVE to evaluate the error under four compression algorithms, one of which is the SW-MSVE algorithm. The results show that the SVE is less influenced by noise with stronger performance and more applicability. In the second experiment, by marking the raw trajectory, we compare the SW-MSVE algorithm with three others algorithms at information retention. The results show that the SW-MSVE algorithm can take into account both velocity and geometric structure constraints and retains more information of the raw trajectory at the same compression ratio.
Interaction of cholesterol and octadecanol in a mixed adsorbed film at carbon tetrachloride/water interface: criticism about the condensing effect of cholesterol

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteraction of cholesterol and octadecanol in a mixed adsorbed film at carbon tetrachloride/water interface: criticism about the condensing effect of cholesterolNorihiro Matubayasi, Reiko Matsunaga, and Kinsi MotomuraCite this: Langmuir 1989, 5, 4, 1048–1051Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/la00088a030https://doi.org/10.1021/la00088a030research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of antimicrobials penicillin, streptomycin, neomycin, and nystatin in cultures of Acartia tonsa (Copepoda: Calanoida)

Field: Agricultural and Biological Sciences (Life Sciences)

Antibiotics can be used for laboratory cultivation of aquatic organisms in order to inhibit bacterial growth and thus improving survival and a growth and thus improving survival and the development of invertebrates and microalgae. However, the use of these prokaryotes inhibitors on long experiments usually results in an excessive growth of fungi, because of the available niche. Therefore, antifungal substances should also be considered, since it causes no damage to non-target organisms. We tested the effect of a combination of antibiotics previously evaluated successfully in the culture of the marine copepod Acatia tonsa , known for its sensitivity (gL -1 ) (T 0 : 0.025 of penicillin G potassium + 0.08 of streptomycin sulfate + 0.04 of neomycin sulfate), compared to this combination increased of different concentrations of antifungal nystatin: T 1 : 0.0025; T 2 : 0.005; T 3 : 0.01; T 4 : 0.015; T 5 : 0.02; T 6 : 0.025 gL -1 and control (without antibiotics). The treatments were first tested in the culture of A. tonsa . Copepods were fed with the microalgae Conticribra weissflogii , and the cultures medium were renewed daily. The treatments that presented the best survival results were also tested to check its effectiveness inhibiting bacterial biofilm and fungi formation with 3, 6, 9, 12, 15, 18, 21, 24, 48 and 168 hours of exposure without renewal of the medium. Treatments T 0 , T 1 and T 2 presented similar survival results of A. tonsa as those of control after 96 hours of exposure (p> 0.05). Regarding microbiological inhibition, those three treatments showed equivalent and significant reduction in bacterial density (up to 95 % with 12 hours of exposure) compared to control (p<0.008). However, only treatment T 2 prevented fungal colonization after 168 hours of exposure. Thus, the treatment T 2 can be used in laboratory cultivation of the copepod A. tonsa without the interference of bacteria and fungi.
The Immunohistochemical Characterization of Devil Facial Tumor Disease (DFTD) in the Tasmanian Devil (Sarcophilus harrisii)

Field: Veterinary (Health Sciences)

Immunohistochemical techniques were used to characterize the disfiguring and debilitating fatal neoplastic disease, devil facial tumor disease (DFTD), which has recently affected a significant proportion of the wild population of Tasmanian Devils ( Sarcophilus harrisii). The diagnostic values of a number of immunohistochemical stains were employed to further characterize 50 representative cases. The neoplasms were negative for cytokeratin (0/48), epithelial membrane antigen (0/42), von Willebrand factor (vWF) (0/11), smooth muscle actin (SMA) (0/26), desmin (0/47), glial fibrillary acid protein (0/13), CD16 (0/13), CD57 (0/43), CD3 (0/18), and LSP1 (0/16). DFTD cells were positive for vimentin (50/50), S-100 (41/48), melan A (11/39), neuron specific enolase (35/35), chromogranin A (12/12) and synaptophysin (29/30). The cells were negative for amyloid (0/30) and stained negatively with Singh's silver (0/34) but were weakly argyrophilic (3/40) using Grimelius histochemical stain. These staining characteristics are consistent with cells of neuroectodermal origin.
Recent Advance in Electrochromic Materials and Devices for Display Applications

Field: Materials Science (Physical Sciences)

Abstract Electrochromic devices (ECDs) possess the performance advantages in terms of color adjustability, low power consumption, and visual friendliness, emerging as one of the ideal candidates for energy‐efficient smart windows, next‐generation displays, and wearable electronics. The optical and electrical characteristics of ECDs can be adjusted by modifying the materials or structure of devices. This review summarizes the recent developments of innovative technologies and key materials of ECDs for display applications, highlighting the key issues and development trends in this area.