jimnoneill/paper-to-field-training huggingface dataset:
Results of a prospective phase II national study: Prophylactic radical fimbriectomy (NCT01608074), in women with a documented high risk of breast/ovarian cancer—Final pathological results and outcomes.

Field: Medicine (Health Sciences)

1594 Background: Risk-reducing salpingo-oophorectomy (RRSO) is the gold standard in surgical prophylaxis of pelvic high-grade serous carcinoma (HGSC) for women at risk of breast/ovarian cancer. Due to significant adverse effects of early oophorectomy, 20-30% of women delay or deny performing this operation. Recent data highlight the fallopian origin of most pelvic HGSC, especially its fimbrial part. Thus, we suggested a new two-step risk-reducing procedure: the radical fimbriectomy (RF) with delayed oophorectomy (DO) (Leblanc et al Gyn Oncol 2011), leading to the current RF/DO Phase 2 study. We present the definitive results on primary and secondary objectives of this trial. Methods: BRCA1/2 carriers or any women with a documented familial risk of breast/ovarian cancer were first counseled to perform a classical laparoscopic RRSO. If they denied, they were offered to enter the RF/DO study. All specimens were submitted to the SEE-FIM pathological protocol. Pathological data along with all intra- and 30-day and beyond post-operative adverse events were prospectively recorded. Follow-up consisted in an annual clinical breast and gynecological examination, with tumor markers and hormonal status assessment. Primary endpoint was the rate of pelvic serous carcinoma. Secondary endpoints were procedure morbidity, rates of tubal abnormalities, breast cancer, secondary oophorectomy. Results: From January 2012 to October 2014, 121 RF were performed: 120 by laparoscopy, 1 laparotomy (concurrent myomectomy). An occult neoplasia was found in 3 cases with 1 invasive HGSC. Intraoperative complications were two grade1 bleedings without transfusion with no grade ≥3 early post-operative or delayed complication. With a median follow-up of 5.3 years (0.2 -7.6), no patient developed any pelvic HGSC, 21 patients developed a breast cancer (3 de novo, 18 recurrences/contralateral.). 1 cancer-free BRCA1-mutated lady delivered safe twins, after an uneventful post-RF pregnancy obtained with assisted reproductive technology (ART). Overall, 29 women underwent DO (by choice: 12 or menopause: 17) resulting in grade 3b complication in 1 case, but no pathological abnormality. Conclusions: RF/DO appears as a safe, well tolerated and effective procedure in terms of occult neoplasia detection. A successful pregnancy with ART was possible after radical fimbriectomy. Longer follow-up and larger cohort are necessary to confirm its efficacy in terms of ovarian cancer prophylaxis. Clinical trial information: NCT01608074.
7. Trade Marks II

Field: Arts and Humanities (Social Sciences)

All books in this flagship series contain carefully selected substantial extracts from key cases, legislation, and academic debate, providing able students with a stand-alone resource. This chapter discusses the relative grounds for refusal to register a trade mark; acts that constitute infringement; and remedies for infringement. It considers the finding of the Court of Justice of the EU that the investment, advertising, and commercial functions of a trade mark will be protected as well as its role as a badge of origin in cases of ‘double identity’ under the Trade Marks Directive. The chapter considers possible changes to the position under the new Trade Marks Directive and looks at the CJEU’s interpretation of cases where a third party is deemed to have taken unfair advantage of a trade mark with a reputation. It also discusses the use of trade marks on the internet and the implications for findings of infringement.
Accuracy improved double-talk detector based on state transition diagram

Field: Computer Science (Physical Sciences)

A double-talk detector (DTD) is generally used with an acoustic echo canceller (AEC) in pinpointing the region where far-end and near-end signal coexist. This region is called double-talk and during this region AEC usually freezes the adaptation. Decision variable used in DTD has a relatively longer transient time going from double-talk to single-talk than time going in opposite direction. Therefore, using a single threshold to pinpoint the location of double-talk region can be difficult. In this paper, a DTD based on a novel state transition diagram and a decision variable which requires minimal computational overhead is proposed to improve the accuracy of pinpointing the location. The use of different thresholds according to the state helps the DTD locate double-talk region more accurately. The proposed DTD algorithm is evaluated by obtaining a receiver operating characteristic (ROC) and is compared to that of Cho’s DTD.
[Can radioactive iodine be used in the treatment of diffuse non-toxic goiter?].

Field: Medicine (Health Sciences)

Traditional treatment modalities of diffuse nontoxic goitre are thyroid hormone suppression or surgery. When treating nodular nontoxic goitre with 131I treatment, a reduction in thyroid volume to about 50% is seen. In the present study we evaluated the effect of 131I treatment in 21 patients treated for a diffuse nontoxic goitre and followed by evaluation of thyroid volume measured by ultrasound. Thyroid volume declined in all patients from median of 66 ml (range 27-160 ml) to 21 ml (9-108 ml) over a year, a reduction of 62%. Three patients developed hypothyroidism in the follow-up period (14%), one of these had a temporary hyperthyroid fase. In conclusion, 131I treatment of diffuse nontoxic goitre reduces thyroid volume by approximately 60% within 12 months. Hypothyroidism developed in 14% during a limited follow-up period.
Dial Tone Drone

Field: Arts and Humanities (Social Sciences)

For Telephone, Satz focusses on the familiar pitch of the electronic dial tone, a signal of live telephonic connection which came into widespread use in 1950s. Considering the dial tone as an open field of potential communication, Satz talked with electronic music pioneers Laurie Spiegel and Pauline Oliveros on the technological and perceptual implications of composing and listening to sustained musical notes, known as drone music. Excerpts of the conversations, recorded via Skype and IPhone, are played against compositions by the two composers, probing the political, musical and conceptual implications of the drone.
Dial Tone Drone features excerpts from ‘Horse Sings From Cloud’ (1975), an accordion score by Pauline Oliveros, and ‘Expanding Universe’ (1974-76), a computerised composition by Laurie Spiegel.
The commission is a companion piece to Satz’s work Dial Tone Operator, on show as part of ‘Mirrorcity’ at Hayward Gallery. To coincide with the launch of the commission there was a live performance with Elaine Mitchener and Jennifer Walshe at the Hayward Gallery on the 15th November 2015.

Further exhibitions: Group exhibition at 44th International Film Festival Rotterdam (Rotterdam, 2015); CONTEXT Art Miami, group exhibition curated by Christoph Cox (Miami, 2015); 'Where there is sea there are pirates', group exhibition at 3 137 Gallery (Athens, 2016).
Training Technology Handbook for System Acquisition Planners: Preliminary Version.

Field: Decision Sciences (Social Sciences)

The objective of this effort was to generate the data for and develop a preliminary training technology handbook. The final form of this handbook is intended to assist hardware acquisition managers, training program developers, and others in estimating the composition and cost of training required for new weapon system acquisitions. This report is being released at this time as a working draft to provide for distribution to the research community. Further development will be required before the handbook is ready for broad application within the hardware acquisition community.
Cloud based AI approach for predictive maintenance and failure prevention

Field: Computer Science (Physical Sciences)

Abstract Every industry has utilized machines of various types for many functions. The manufacturing industry has utilized machines since the industrial revolution for mass manufacturing. Operating machines continuously can lead to faults and require maintenance and repairs. As computing power increased and various technologies such as embedded systems, artificial intelligence, deep learning, cloud computing etc. were developed, new systems were implemented to perform diagnostics on machines. In this paper, A conceptual system architecture of a cloud based AI system to predict potential failure of a component by analyzing data collected from various sources and develop inspection and maintenance schedules is proposed. The application of technologies such as Artificial Intelligence, Cloud computing and process mining in the system is discussed in detail. The operation of the system in a real world condition is discussed by developing a system architecture for maintenance and failure prediction of aircraft fan blades of an aircraft engine. The future application of the system with potential increase in capability is discussed.
Using Word Based Features for Word Clustering

Field: Computer Science (Physical Sciences)

In the holistic technique (HT) the whole information of the Arabic word is calculated using many possible features. In this paper, this approach is used to test the possible uses of the HT in the Arabic OCR systems. The HT is used to reduce the possible candidates for each word. We succeeded to reduce the candidates to around 115 with accuracy over 99%, given a single font and a single size from a large lexicon of more than 356K words. This vocabulary size has a good coverage for the Arabic Language. This means that the problem facing the OCR classifier is tremendously reduced, and much higher accuracy can be expected for the OCR systems.Â Â
[Automatic sleep staging based on power spectral density and random forest].

Field: Computer Science (Physical Sciences)

The method of using deep learning technology to realize automatic sleep staging needs a lot of data support, and its computational complexity is also high. In this paper, an automatic sleep staging method based on power spectral density (PSD) and random forest is proposed. Firstly, the PSDs of six characteristic waves (K complex wave, δ wave, θ wave, α wave, spindle wave, β wave) in electroencephalogram (EEG) signals were extracted as the classification features, and then five sleep states (W, N1, N2, N3, REM) were automatically classified by random forest classifier. The whole night sleep EEG data of healthy subjects in the Sleep-EDF database were used as experimental data. The effects of using different EEG signals (Fpz-Cz single channel, Pz-Oz single channel, Fpz-Cz + Pz-Oz dual channel), different classifiers (random forest, adaptive boost, gradient boost, Gaussian naïve Bayes, decision tree, K-nearest neighbor), and different training and test set divisions (2-fold cross-validation, 5-fold cross-validation, 10-fold cross-validation, single subject) on the classification effect were compared. The experimental results showed that the effect was the best when the input was Pz-Oz single-channel EEG signal and the random forest classifier was used, no matter how the training set and test set were transformed, the classification accuracy was above 90.79%. The overall classification accuracy, macro average F1 value, and Kappa coefficient could reach 91.94%, 73.2% and 0.845 respectively at the highest, which proved that this method was effective and not susceptible to data volume, and had good stability. Compared with the existing research, our method is more accurate and simpler, and is suitable for automation.
An Algorithmic Approach to Error Correction: An Empirical Study

Field: Arts and Humanities (Social Sciences)

This article reports on the results of a research study that investigated the effectiveness of using an algorithmic approach to error correction to help Hong Kong English‐as‐a‐second‐language (ESL) learners overcome persistent lexico‐grammatical problems. Ten error types were selected for the experiment, and one set of remedial instructional materials was designed for each error type. The materials were implemented with more than 450 students at both secondary and tertiary levels. Pretests, posttests, and delayed posttests were administered to test the effectiveness of the approach, and a plenary review meeting was organized to gather feedback. The results showed that the approach was versatile and effective and that the students showed significant improvements for the items taught. It is argued that form‐focused remedial instruction is effective in enhancing learners' language accuracy in their second language (L2) output.
Inhibition of adipocyte and whole-tissue lipoprotein lipase by rat high-density lipoprotein

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Conference Article| February 01 1985 Inhibition of adipocyte and whole-tissue lipoprotein lipase by rat high-density lipoprotein SHEELAGH M. A. JONES; SHEELAGH M. A. JONES 1Department of Biochemistry, University of Newcastle upon Tyne, Newcastle upon Tyne NEI 7RU, U.K. Search for other works by this author on: This Site PubMed Google Scholar M. PERENNA ROGERS M. PERENNA ROGERS 1Department of Biochemistry, University of Newcastle upon Tyne, Newcastle upon Tyne NEI 7RU, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1985) 13 (1): 130–132. https://doi.org/10.1042/bst0130130 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation SHEELAGH M. A. JONES, M. PERENNA ROGERS; Inhibition of adipocyte and whole-tissue lipoprotein lipase by rat high-density lipoprotein. Biochem Soc Trans 1 February 1985; 13 (1): 130–132. doi: https://doi.org/10.1042/bst0130130 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: HD lipoprotein, high-density lipoprotein This content is only available as a PDF. © 1985 Biochemical Society1985 Article PDF first page preview Close Modal You do not currently have access to this content.
The meta-ethical significance of experiments about folk moral objectivism

Field: Arts and Humanities (Social Sciences)

The meta-ethical commitments of folk respondents – specifically their commitment to the objectivity of moral claims – have recently become subject to empirical scrutiny. Experimental findings suggest that people are meta-ethical pluralists: There is both inter- and intrapersonal variation with regard to people’s objectivist commitments. What meta-ethical implications, if any, do these findings have? I point out that current research does not directly address traditional meta-ethical questions: The methods used and distinctions drawn by experimenters do not perfectly match those of meta-ethicists. However, I go on to argue that, in spite of this mismatch, the research findings should be of interest to moral philosophers, including meta-ethicists. Not only do these findings extend the field of moral psychology with new data and hypotheses, but they also provide tentative evidence that touches on the adequacy of theses in moral semantics and moral metaphysics. Specifically, they put pressure on arguments in support of moral realism.
26.4 A Cell-Capacitance-Insensitive CMOS Sample-and-Hold Chronoamperometric Sensor for Real-Time Measurement of Small Molecule Drugs in Whole Blood

Field: Engineering (Physical Sciences)

The capability of adjusting a drug-dosing profile in real time based on personalized pharmacokinetics plays a crucial role in achieving optimal therapeutic outcomes at minimal toxicity [1]. Achieving this requires biosensors that can continuously measure drug concentrations at sub-minute temporal resolution. Today, the gold standard methods such as immunoassays and liquid chromatography are not able to achieve this because they require long assay times (typically hours). Recently, structure-switching aptamers have drawn great attention for in vivo realtime monitoring [2]-[4]. As shown in Fig. 26.4.1, aptamers are single-stranded DNA molecules whose sequences are selected to bind target molecules with high affinity [2]. To achieve electrochemical detection, redox reporters (such as methylene blue, MB) are conjugated to these aptamers such that conformation changes in the aptamer caused by target binding leads to a direct electrical readout in proportional to the target concentration. Such a reagent-free capability has been demonstrated using microfluidics and implanted probes measuring chemotherapeutics and aminoglycoside antibiotics [2]-[4]. To generalize the technology for ambulatory patients, [5] presents a system integrating an aptamer-interfacing electrochemical circuit with wireless powering and telemetry.
[Right Brachial Artery Thromboembolism After Left Upper Lobectomy].

Field: Medicine (Health Sciences)

A 71-year-old man underwent a computed tomography( CT) scan to check for prostate cancer metastasis. It revealed a lung tumor in the left upper lobe, and he was referred to our division. Under clinical diagnosis of primary lung cancer, left upper lobectomy was performed. Dense adhesion due to the history of tuberculosis was observed. On the first postoperative day, he complained of sudden numbness in his right arm during rehabilitation. The emergent contrast-enhanced CT revealed the right brachial arterial thromboembolism. We performed an embolectomy, and further analysis of the postoperative enhanced CT revealed a longer left upper pulmonary vein stump than usual. We thought it to be the cause of the thrombus formation and started anticoagulation therapy. The postoperative course was uneventful, without recurrence of thromboembolism.
Realization of a Simplified Controllability Computation Procedure: a MATLAB- SIMULINK Based Tool

Field: Computer Science (Physical Sciences)

With the use of MATLAB-SIMULINK a simple tool has been developed to compute the controllabilities of nodes as well as branches of digital system networks. The primary advantage of this tool may be for such conditions where the study of controllability analysis of a system with different possible designs is required to give an optimal design solution. The ease of network simulation procedures together with the simple methodologies for inputting the different assigned parameters to the respective elements of the system in dynamic environments, are additional attributes of this tool.
Ethics, Rhetoric, and Politics of Post-Conflict Reconstruction: How Can the Concept of Social Contract Help Us in Understanding How to Make Peace Work?

Field: Social Sciences (Social Sciences)

Theoretical and empirical studies analysing various ethical aspects of inter-national relations — and particularly those related to war, peace and conflict resolution — have primarily focused on the moral justification of war and intervention, as well as on 'the ethics of peace'1 by analysing the plausibility of various moral, political and economic means and ends in peacemaking. Since existing injustices and the quest for justice are usually seen to be the main causes for violent clashes, it is often claimed that the creation or restoration of justice must be the most important goal of post-conflict reconstruction. However, the current policy approaches, social movements, and theoretical models for conflict resolution tend to look at justice from merely a technical point of view, as a rapid fix to overcome war and violence. This relates the notion of 'peace' to 'security', and replaces the concept of 'justice' with the concepts of 'law and order'. Creation or restoration of justice, however, does not merely mean establishment of the rule of law; it has wider moral dimensions. Therefore, the concept of justice, and the normative framework justice offers to lasting social harmony, needs to be considered in relation to local social ethics and values, and to the public ethics requirement of impartiality.KeywordsSecurity CouncilSocial ContractSocial HarmonySocial Contract TheoryStructural ViolenceThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
The Price of Anarchy and Computation of Equilibria in Non-atomic Consumption-Relevance Congestion Games

Field: Mathematics (Physical Sciences)

We present an extension to the model of non-atomic congestion games (NCG). NCGs enforce a symmetry between the consumption of elements (e.g., network links) and their relevance for the players: players utilizing an element e through a strategy S (e.g., a multicast tree) with rate of consumption C_{eS}>0 experience the element's latency amplified by that same factor C_{eS}. Our extension instead allows a factor R_{eS}, independent of C_{eS}, to express the amplification of the element's latency from the players' perspective, or, in other words, the relevance of element e for strategy S. We therefore call the extended model non-atomic consumption-relevance congestion games (NCRCG). NCRCGs exhibit new phenomena, including multiple Nash equilibria of different social cost and -- even from a worst-case point of view -- a dependence of the price of anarchy on structural parameters not limited to the class of element latency functions used. It poses new computational challenges. We prove almost tight lower, upper, and bicriteria bounds for the price of anarchy for super-homogeneous classes of element latency functions. We show a positive computational result for affine element latency functions. A summary of experimental results is given, which suggest that our lower bound is the best possible.
On Proposals for Introducing Criminal Responsibility for Arbitrators

Field: Social Sciences (Social Sciences)

The paper provides a critical analysis of the draft law on the introduction of certain norms in the Criminal Code of the Russian Federation concerning the criminal responsibility of arbitrators. The authors present a number of arguments regarding the fact that the prerequisites for the introduction of such responsibility in Russia are currently absent, since the issue is not sufficiently theoretically developed. Issues related to determining the legal responsibility of an arbitrator in various legal systems are considered. The authors substantiate the thesis that in the existing conditions other legal instruments for stimulating the proper activity of arbitrators are more effective, a number of which are successfully applied. In addition, the implementation of the initiative in modern conditions may involve costs that exceed the expected result. It is proved that in the case of imposition of responsibility for arbitrators a set of safeguards activities of arbitrators should be simultaneously legislated. Here, the authors propose to establish guarantees of non-interference in professional activities of an arbitrator as well as legal responsibility for obstructing the activities of an arbitrator’s resolution of a particular dispute. The authors suggest that abitritrators be referred to those individuals who are subject to special procedure of criminal proceedings. It is necessary to provide at the legislative level elements of self-regulation associated with the formation of the arbitration bodies who possess significant powers, including regarding the involvement of arbitrators to criminal responsibility. Based on the results of the research, it is concluded that the relevant issues need to be thoroughly and comprehensively worked out and professionally discussed, which may precede possible changes in legislation.