jimnoneill/paper-to-field-training huggingface dataset:
Comparison between Deflated Balloon-Facilitated Direct Stenting and Balloon Pre-Dilatation in ST Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention

Field: Medicine (Health Sciences)

Abstract Background PPCI is considered to be the preferred reperfusion strategy for acute coronary syndrome (ACS). The goal of reperfusion is to resume normal blood flow to the cardiac tissues, and not just to achieve an open epicardial artery. Although no-reflow may occur regardless of the method of revascularization, it is easily diagnosed with certainty during acute percutaneous coronary intervention (PCI) in STEMI. Objective To evaluate the efficacy of Deflated Balloon-Facilitated Direct Stenting in comparison with routine Balloon Pre-dilatation in STEMI Patients undergoing PPCI. Patients and Methods It included 160 patients who were presented with ST segment elevation myocardial infarction (STEMI) and underwent primary PCI at Ain Shams University Hospitals and Misr University for Science and Technology (MUST) university hospital in the period of March 2021 to december 2021. Results In our study group 2 showed the best results as regards No-reflow (23.33% vs 6.67% vs 27.5% in group 1, 2 and 3 respectively) with p-value (0.011), final MBG (II-III) (76.67% vs 93.33% vs 72.5% in group 1, 2 and 3 respectively) with p-value (0.011) and final TIMI III (91.67% vs 95% vs 90% in group 1, 2 and 3 respectively) with p-value (0.838). It was found that group 1 showed the shortest procedure time (measured in minutes) (46.83±15.43 vs 52±13.54 vs 59.75±14.59, in group 1, 2 and 3 respectively) with p-value (0.054) and smallest contrast volume (measured in milliliters) (101±19.09 vs 120.67±28.99 vs 136.25±24.67, in group 1, 2 and 3 respectively) with p-value (&lt;0.001). While group 3 had the worst outcomes among all groups. Conclusion Routine predilatation technique is associated with better results when compared with deflated balloon-facilitated direct stenting technique. One of the major disadvantages of deflated balloon-facilitated direct stenting is not being able to restore the flow distal to the lesion, which necessitate using balloon dilatation, leading to more incidence of no-reflow (we aquire the disadvantages of both techniques combined) Abbreviations ACS: Acute coronary syndrome; CAD: Coronary artery disease; CBC: Complete blood picture; CKD: Chronic kidney disease; CVS: cerebrovascular disease; DBDS: Deflated balloon facilitated direct stenting; DM: Diabetes Mellitus; DS: Direct stenting; ECG: Electrocardiogram; EF: Ejection fraction; FH: Family history; GP: Glycoprotein; HTN: Hypertension; IRA: Infarct related artery; LAD: Left anterior descending artery; LCX: Left circumflex artery; MACE: Major adverse cardiac events; MBG: Myocardial blush grade; MI: Myocardial infarction; NR: No reflow phenomenon; PAD: Peripheral arterial disease; PCI: Percutaneous coronary intervention; PD: Predilatation; PPCI: Primary percutaneous coronary intervention; RCA: Right coronary artery; STEMI: ST-segment elevation myocardial; SWMA: Segmental wall motion abnormalities; TIMI: Thrombolysis in myocardial infarction risk score
High tumor necrosis factor alpha (TNF-a) production in Trypanosoma cruzi-infected pregnant mice and increased TNF-a gene transcription in their offspring

Field: Immunology and Microbiology (Life Sciences)

Since tumor necrosis factor alpha (TNF-a) is known to be involved in the feto-maternal relationship, this cytokine was studied in Trypanosoma cruzi-infected pregnant BALB/c mice and their fetuses and offspring. Pregnant chronically infected mice displayed significantly higher levels of circulating TNF-a than animals either only infected or only pregnant. TNF-a was undetectable in sera of uninfected and nonpregnant mice as well as in breast milk obtained from infected and uninfected animals. Fetuses from infected mice exhibited significantly more cells containing TNF-a mRNA in their thymus than fetuses from uninfected mothers. When infected 2 months after birth, offspring born to infected and uninfected mothers displayed similar amounts of circulating TNF-a during chronic infection, whereas this cytokine was only weakly detectable during the acute phase of the disease. An intravenous injection of lipopolysaccharide during acute infection strongly increased the production of TNF-a in offspring born to infected mothers to levels higher than those in progeny from uninfected mice. These results suggest that TNF-a is an important cytokine in the feto-maternal relationship during T. cruzi infection and that fetuses and offspring of infected mothers are primed to produce elevated levels of TNF-a. In previous studies of the feto-maternal relationship in ex-perimental Trypanosoma cruzi infections, we have reported the
A STUDY ON THE ORIGIN OF INTRARETINAL ACTION POTENTIAL OF THE CYPRINID FISH BY MEANS OF PENCIL-TYPE MICROELECTRODE

Field: Neuroscience (Life Sciences)

1. Pencil-type microelectrodes consisting of a superfine inner pipette and a Ringer-filled outer pipette (5μ) were applied to the retina of the Cyprinid fish (Cyprinus auratus) to record the intraretinal action potentials (EIRG's).2. The configuration of the EIRG was typical of Svaetichin's cone action potential. The depth for maximal EIRG's was 80-90μ from the vitreous side and 160-170μ from the distal tips of rods, and appeared histologically to be proximal to the receptors.3. When an electrode was used with its inner pipette protruded a fixed length out of the tip of the outer pipette, both pipettes recorded similar EIRG's depending upon the depth of their insertion into the retina. With a tip distance of less than 30μ, the simultaneously recorded EIRG's through both pipettes were usually so identical that it was difficult to obtain their separate tracings.4. It was concluded that the EIRG has its main origin in a retinal layer proximal to the receptors and that the recording of the EIRG may not be intracellular.
The Dual Origin of <i>Toxoplasma gondii</i> <i>N</i>-Glycans

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

N-Linked glycosylation is the most frequent modification of secreted proteins in eukaryotic cells that plays a crucial role in protein folding and trafficking. Mature <i>N</i>-glycans are sequentially processed in the endoplasmic reticulum and Golgi apparatus through a pathway highly conserved in most eukaryotic organisms. Here, we demonstrate that the obligate intracellular protozoan parasite <i>Toxoplasma gondii</i> independently transfers endogenous truncated as well as host-derived <i>N</i>-glycans onto its own proteins. Therefore, we propose that the apicomplexan parasite scavenges N-glycosylation intermediates from the host cells to compensate for the rapid evolution of its biosynthetic pathway, which is primarily devoted to modification of proteins with glycosylphosphatidylinositols rather than <i>N</i>-glycans.
Sparse Crystals

Field: Physics and Astronomy (Physical Sciences)

Atoms in ordinary matter are held together through bonds formed by electrons and are dominated by the rules of quantum mechanics. In a purely classical solid, however, an array of charged particles can be held together by electrostatic forces. In his research commentary, Schiffer discusses work reported in the same issue by Itano et al. in which the cubic ordering of a Coulombic crystalline solid has been observed for the first time.
An exploration of metacognition and its interplay with other forms of conscious thought processing in independent learning at tertiary level.

Field: Psychology (Social Sciences)

Educators are increasingly required to assist learners not simply with subject content, but with developing metacognitive skills for independent learning, interdisciplinary learning and lifelong learning. However, there is a dearth of research on how metacognitive processing interacts with other forms of processing in authentic, real-world learning environments. In light of this, this study concerned itself with furthering understanding of metacognition, cognition and its interactions with other forms of conscious thought processing within the real-world setting of a Self-Access Learning Centre (SALC) supporting independent learning at tertiary level in Japan. \n \nThis study employed a Grounded Theory Methodology, based on a constructivist paradigm, to explore the various forms of processing that occur during independent learning. A sample of 47 students in a Japanese University undertook a range of independent learning tasks individually and/or as part of a group. Verbal protocol analysis, discourse analysis, audio and video recordings were used to record various forms of processing that emerged during the implementation of the tasks within this independent learning context. This data was then subjected to the rigorous process of constant comparison, through which codes were developed, and the categories of processing, the processing sequences and the interplay between thought processes during independent learning were elucidated. As an exploratory study, the findings cannot be considered widely applicable to larger, more diverse learner populations. \n \nThe findings have added new knowledge to the fields of metacognition and independent learning by identifying the categories of processing that account for all conscious processing occuring during independent learning. The resultant grounded theory posits that different types of processing, namely, metacognitive, cognitive, affective, physical and off-task processing, interact to influence the learning experience in independent learning. Finally, it postulates that each type of processing is multi-dimensional and that the interactions within and between these processes and the learning experience are non-linear and complex.
Seismic Design of Hybrid Coupled CLT Shear Walls with Steel Link Beams

Field: Engineering (Physical Sciences)

ABSTRACT This study proposes a seismic design method for hybrid coupled cross‐laminated timber (CLT) shear walls with steel link beams as the lateral load‐resisting system for mass timber buildings. A force‐based seismic design method was proposed as a preliminary design process to determine the primary structural components. To inform the selection of several factors in the design method, a series of pushover analyses were conducted on 23 prototype configurations with CLT wall piers and steel link beams of varying size. Based on the results, it is recommended to use a minimum ratio of wall pier length to link beam length of 3 and a degree of coupling factor ( β , which defines the portion of overturning resisted by link beams) between 0.5 and 0.6. Coupled CLT walls were then designed for sample buildings of 6, 8 and 10 storeys using the proposed design method, and their expected seismic performance was evaluated using pushover and non‐linear time‐history analyses (NLTHA). For ultimate limit state (ULS) seismic events, only the six‐storey building experienced collapse for one of twelve ground motions, which may indicate unacceptable performance depending on the acceptance criteria set by the design engineer. The mean peak drift predicted by the non‐linear analyses for the set of buildings was 1.6% which is below the common 2.5% limit for ULS events set by building codes. The NLTHAs predicted greater deformation demands than the pushover analyses for all three sample buildings, in part because they explicitly consider stiffness degradation and the system's pinched hysteretic behaviour. In general, the proposed design parameters were appropriate for the proposed hybrid coupled CLT shear wall system but non‐linear verification is still essential to verify the force‐based design.
Production of 92Y via the 92Zr(n,p) reaction using the C(d,n) accelerator neutron source

Field: Physics and Astronomy (Physical Sciences)

We have proposed a new method of producing medical radioisotope 92Y as a candidate of alternatives of 111In bioscan prior to 90Y ibritumomab tiuxetan treatment. The 92Y isotope is produced via the 92Zr (n,p) reaction using accelerator neutrons generated by the interaction of deuteron beams with carbon. A feasibility experiment was performed at Cyclotron and Radioisotope Center, Tohoku University. A carbon thick target was irradiated by 20-MeV deuterons to produce accelerator neutrons. The thick target neutron yield (TTNY) was measured by using the multiple foils activation method. The foils were made of Al, Fe, Co, Ni, Zn, Zr, Nb, and Au. The production amount of 92Y and induced impurities were estimated by simulation with the measured TTNY and the JENDL-4.0 nuclear data.
‘The Work You Want, The Help You Need’: Constructing the Customer in Jobcentre Plus

Field: Social Sciences (Social Sciences)

In this article we explore the concept of the customer and its application within the contemporary public sector. While the centrality of the customer ideal to ‘the new public management’ is clear, the nature, appropriateness and implications of its use are less so. Debates on these issues turn on meanings ascribed to the customer role. In the first part of the article we consider shifting conceptions of the customer appearing in literatures on consumption, organization and the new public management. The second part of the article explores the representation of the customer in an organization emblematic of the new public management in Britain. Jobcentre Plus is an emerging organization charged with delivery of the government’s work-focused welfare agenda. The agency is involved in constructing customers from what once were benefit claimants and/or the unemployed. Through analysis of internal and public documents and observation of six sites, we explore the explicit and implicit meanings of the customer as conveyed through language and labelling, operational practices and features of the physical environment. We find a complex interaction of narratives of customer sovereignty and control. In the final part of the article we consider how this case may be read according to the academic narratives previously outlined.
A review of the school science curricula in eleven high achieving jurisdictions

Field: Social Sciences (Social Sciences)

ABSTRACT The last two decades have seen unprecedented interest in science curricula, with many governments seeing improvements in the performance of their school students in science as key to future economic prosperity. We present the results of an analysis of the curriculum documents for primary and secondary science in Australia (New South Wales and Queensland), Canada (Alberta and Ontario), Finland, Japan, Singapore, Hong Kong, Shanghai and the United States (Florida and Massachusetts). Beyond our specific findings, we note a degree of convergence across these 11 very different jurisdictions. The Asian ones have made and are making changes to encourage students to be more creative and better able to apply their science knowledge and develop their scientific literacy; the ‘Western’ ones are becoming more knowledge focused.
Pig conceptuses utilize extracellular vesicles for interferon-gamma-mediated paracrine communication with the endometrium

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Interferon-gamma (IFNG) is a pro-inflammatory cytokine secreted by the porcine conceptus (embryo and extra-embryonic membranes) during the peri-implantation period of pregnancy. IFNG modifies the endometrial inflammatory immune response and is required for the implantation and survival of the conceptus. It is not known how IFNG from the conceptus trophectoderm is transported across the endometrial luminal epithelium (LE). In the present study, immunofluorescence analyses detected immunoreactive IFNG protein in both the trophectoderm and endometrial LE on Day 15 of pregnancy, while our previous research localized IFNG mRNA only to conceptus trophectoderm. Using minced endometrial explants to disrupt the barrier posed by the intact endometrial LE, treatment with recombinant IFNG induced the expression of genes that were not induced when IFNG was infused into the uterine lumen in vivo by McLendon et al. (Biology of Reproduction. 2020;103(5):1018–1029). We hypothesized that during pregnancy extracellular vesicles (EVs) serve as intercellular signaling vehicles to transport conceptus-derived IFNG across the intact endometrial LE and into the stromal compartment of the uterus. Western blotting detected the presence of IFNG in EVs isolated from the uterine fluid of pregnant gilts, but not nonpregnant gilts. Real-time PCR demonstrated increased expression of IFNG-stimulated genes in EV-treated endometrial explants and EV-mediated IFNG transport was confirmed in whole uterine sections cultured with EVs from Day 15 of pregnancy. These results suggest that EVs are involved in IFNG transport across the endometrial LE to enable paracrine communication between the conceptus and cells within the endometrial stroma.
Glucose Catabolism Induces the L-Type Pyruvate Kinase Gene (125a)

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Conference Article| May 01 1996 Glucose Catabolism Induces the L-Type Pyruvate Kinase Gene (125a) Bruno DOIRON; Bruno DOIRON 1Institut Cochin de Génétique Moléculaire, INSERM U-129, 24 rue du Faubourg St Jacques, 74014, Paris, France Search for other works by this author on: This Site PubMed Google Scholar Marie-Hélène CUIF; Marie-Hélène CUIF 1Institut Cochin de Génétique Moléculaire, INSERM U-129, 24 rue du Faubourg St Jacques, 74014, Paris, France Search for other works by this author on: This Site PubMed Google Scholar Axel KAHN Axel KAHN 1Institut Cochin de Génétique Moléculaire, INSERM U-129, 24 rue du Faubourg St Jacques, 74014, Paris, France Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1996) 24 (2): 250S. https://doi.org/10.1042/bst024250s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Bruno DOIRON, Marie-Hélène CUIF, Axel KAHN; Glucose Catabolism Induces the L-Type Pyruvate Kinase Gene (125a). Biochem Soc Trans 1 May 1996; 24 (2): 250S. doi: https://doi.org/10.1042/bst024250s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1996 Biochemical Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
Poultry meat and food safety: pre- and post-harvest approaches to reduce foodborne pathogens

Field: Agricultural and Biological Sciences (Life Sciences)

Poultry and poultry products have repeatedly been implicated as a source of foodborne infection for humans. The significant increase in the number of reported foodborne disease outbreaks worldwide has altered opinions on food safety. It has become clear that current legislation alone is inadequate, and that industry must accept a greater share of responsibility for the quality and safety of the food it produces. The fact that processing plants are not able to reduce the incidence of pathogenic bacteria effectively in poultry products means that every effort must be made to reduce infection in and/or contamination of the live birds with foodborne pathogens before dispatch to processing plants. The main control strategy should include the following: cleaning the production pyramid from the top, as in the case of Salmonella enteritidis and Salmonella typhimurium, by destroying infected flocks (with compensation), sanitising hatching eggs and limiting the introduction and spread of pathogens at the farm through Good Animal Husbandry Practices (GAHPs). To achieve GAHPs, effective measures of hygiene should be applied to poultry houses and the feed. Reducing salmonella colonisation by using antimicrobial feed additives, competitive exclusion treatment or vaccines is worth consideration. Furthermore, hygienic systems for catching and transporting live poultry must be included. To reduce carcass contamination during processing, thorough schedules for cleaning and disinfection of the equipment and plant are essential. Machine design must permit easy and thorough cleaning. Because the success of any food safety programme on the farm and in the processing plant depends on the hygiene practices of the staff, it is essential to incorporate education programmes for all people involved in the poultry production chain. In the farm-to-fork concept, post-processing food handling is also a very important factor in reducing foodborne infections. Finally, the development and application of acceptable methods for end product decontamination and preservation in the processing plant must be pursued.
GBDT-Based Approach for DDoS Attack Prevention in SDN-Based Cloud Virtual Machine

Field: Computer Science (Physical Sciences)

The foundation of the cloud computing has created contemporary and compelling opportunities in the world of information and communication technology (ICT) environment. Individuals, small and medium-sized businesses, and large corporations can now lease processing, storage, and network resources on an as-needed basis. Whether it can be the deployment of any service or it can be any software-based services as well as any server-oriented needs or data storage, cloud computing has enormously replaced the conventional system with distributed nature. One of the significant attributes is to serve as a data center with high computational capacity. Reliability and availability are two significant parameters when it comes to the topic of cloud data centers. However, the access of the data center is distributed in a cloud computing nature irrespective of many countries and many networks where the individual network is exclusive and unforeseeable by its characteristics. This is made happen due to advancements in virtualization technologies; precisely the VMs can be considered as the rudimentary element for providing services to the consumers from the data centers. Deployment of cloud VM is very significant for maintaining the quality of the services of cloud data centers. Individual consumers are associated with the individual or several distributed VMs in cloud architecture [1]. VM abbreviates the ongoing current system and creates an abstract for the users by hiding the complexities of underlying physical hardware details. These VMs can be allocated in a dynamical and statistical way across dispersed cloud data centers infrastructure to improve application performance for paying customers while efficiently utilizing the service provider's physical resources and alleviating bottlenecks. By focusing to improve the server-side resources, a live VM migration strategy has been used where the researchers must look into the better utilization of the resources and power consumption [2]. A consolidation technique can be proposed by minimizing the number of network switches, which can be turned on in any stipulated time [3]. However, the VM allocation affects the traffic dynamics in this regard.