jimnoneill/paper-to-field-training huggingface dataset:
Comparison of Cytotoxic and Antiproliferative Effects of Benzylidenecyclopentanone Analogues of Curcumin on RBL-2H3 Cells

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Curcumin is a natural yellow pigment isolated from the rhizomes of Curcuma longa L. (turmeric), and has several pharmacological effects and no toxicity in both in animal and human clinical study. However, the problem of curcumin is its stability because of its active methylene moiety. Modification of this moiety to cyclopentanone is expected to increase the stability. Previous study reported that benzylidenecyclopentanone analogues of curcumin showed inhibitory effect on histamine release from RBL-2H3 (rat basophilic leukemia) cells, a tumor analog of mast cells. One of them, the hydroxy-methoxy analog (PGV-0), showed more potent effect than that of curcumin. In the present study, some benzylidenecyclopentanone analogues of curcumin were evaluated for their effects on the viability and proliferation of RBL-2H3 cells. Viable cells were counted under a light microscope with a cells-counting chamber or using the cell viability reagent WST-1. The results showed that mast cell viability and histamine content were not affected by curcumin and benzylidene cyclopentanone for 30 min incubation, however, impaired for overnight incubation. The hydroxy-dimethyl benzylidene analog (PGV-1) strongly decreased the mast cells viability for overnight incubation, and its effect was highest among the other analogues. In the proliferation study, this compound also strongly inhibited the proliferation of mast cells, whereas curcumin and hydroxy-methoxy benzylidene analog inhibited the proliferation slightly. There were no inhibitory effects on mast cells proliferation treated by dibenzylidene; dihydroxybenzylidene; and hydroxy-diethylbenzylidene cyclopentanone. Keywords : viability, proliferation, curcumin, benzylidene cyclopentanone, RBL-2H3 cells
[The Relationship between MicroRNA Expression Profiling in Imatinib-Resistant Cell Line K562/G and Potential Mechanism through FOXO3/Bcl-6 Signaling Pathway].

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The FOXO3/Bcl-6 signaling pathway contributes to imatinib resistance in K562/G cell line, and the miRNA expression profiles showed significant differences between K562/G and K562 cells.
Pengaruh Model Brain Based Learning untuk Meningkatkan Kemampuan Koneksi Matematis dan Pencapaian Self Concept Siswa

Field: Psychology (Social Sciences)

The purpose of this study was to analyze the improvement of students' mathematical connection skills and self-concept with a brain based learning (BBL) model with a scientific approach. The background of this research is that the reality on the ground shows that students' mathematical connection abilities are not as expected. One of the factors causing these problems is learning that does not provide flexibility for students to optimally empower the potential of the brain. This resulted in students having difficulty connecting between materials and the level of student confidence that was lacking. This study uses a quantitative approach with a quasi-experimental method. The sample in this study were 37 students in the control class and 36 in the experimental class. The instrument used is a mathematical connection ability test and a self-concept questionnaire. The results of the study are: 1) the increase in mathematical connection ability with the BBL model is higher than with the scientific approach; 2) the achievement of students' self-concept with the BBL model is better than the scientific approach; 3) there is a relationship between the ability of mathematical connections and students' self-concept with the BBL model. Based on the results of the study, it is hoped that the next researcher can choose a method that can encourage the growth and development of students' positive self-concepts, in order to influence students' beliefs about their abilities, and ultimately affect student achievement.
The effect of a low‐phosphate diet on hematocrit and oxygen transport in uremic rats

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Dietary restriction of phosphate was found to prevent the development of anemia in partially nephrectomized rats. In an attempt to examine the reason for this beneficial effect, hematologic and nephrologic studies were carried out on normal and on partially nephrectomized rats fed either a normal or a low‐phosphate diet. It was first found that a low‐phosphate diet ameliorates the degree of renal impairment found four weeks after partial nephrectomy. Nevertheless, it did not eliminate it, and the degree of uremia actually observed should have been associated with a significant reduction in hemoglobin and red cell mass. However, it did reduce serum phosphate and red cell 2,3‐diphosphoglycerate (2,3 DPG) levels and increase hemoglobin affinity for oxygen to a degree that should impair oxygen transport to the tissues. That the low phosphate actually caused tissue hypoxia with increased stimulation of the bone marrow was furthermore suggested by the observation that normal rats fed a low‐phosphorous diet developed a significant increase above normal in hemoglobin concentration and red cell mass. It was concluded that the effect of a low‐phosphate diet on the anemia of uremia is caused by a combination of reduced renal failure and increased tissue hypoxia.
LHD 2O-AH01-03-03-R01 #176019.45 (analyzed)

Field: Physics and Astronomy (Physical Sciences)

Luminance data of the plasma monitor camera. Time variation of the average and maximum luminance within the ROI (Region of Interests) of the plasma images observed by the 2-O port camera, where ROI is (986,602) - (1032,674) of the original image of 1920x1080. The luminance value is between 0 and 255 in arbitrary unit.
Molecular characterization and function analysis of the rice OsDUF829 family

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Although the number of sequenced plant genomes has been rapidly increasing, many plant proteins in public databases are recognized as proteins with domains of unknown function (DUF). The domain of unknown function DUF829 family consists of plant proteins with an average length of around 220 residues. In this study, we attempted to uncover the biological functions of four DUF829 members (OsDUF829.1–OsDUF829.4) in rice Nipponbare. We classified these proteins into three groups (group I, II and III) using phylogenetic analysis. Real time polymerase chain reaction (PCR) showed that the expression patterns of the four OsDUF829 family members were different in 15 different rice tissues. Under salt and heat stress conditions, the expression level of OsDUF829.2 and OsDUF829.4 was significantly elevated. Overexpression of OsDUF829.2 and OsDUF829.4 in Escherichia coli significantly improved the resistance to salt stress. The obtained results provide important implications for further functional studies of the OsDUF829 family in rice.
The Health Impact Fund

Field: Social Sciences (Social Sciences)

Some 500 million people, including 260 million children under the age of five, have died from hunger and remediable diseases in peacetime in the 30 years since the end of the cold war. This is vastly more than have perished from wars, civil wars, and government repression over the entire twentieth century. And poverty continues unabated, as the official statistics amply confirm: of the 7.6 billion people alive today, 821 million are officially counted as undernourished, 150 million are homeless and about 1.6 billion lack adequate shelter, 2.1 billion have no safe drinking water at home, and 4.5 billion lack safe sanitation, 1.2 billion lack electricity, 2 billion are lacking access to essential medicines, 750 million adults are illiterate, and 152 million children (aged 5–17) are victims of child labor – often under slavery-like and hazardous conditions as soldiers, prostitutes, or domestic servants or in agriculture, construction, or textile or carpet production.
Craniofacial Approach for Resection of Large Paranasal Tumors Involving the Anterior Skull Base and Upper Clivus Lesions Guided by Navigation Techniques

Field: Medicine (Health Sciences)

Frontobasal or clival tumors with paranasal extension often need a combined ENT and neurosurgical approach for complete tumor resection. With regard to the extent of tumor resection and procedure-related morbidity, most pathologies in these regions are difficult to treat. Due to destruction of osseous landmarks of the skull base or paranasal sinuses, the anatomical orientation during surgery is also impeded. In this setting, computer-assisted surgical (CAS) guidance provides a useful tool. We report on a series of patients operated on by craniofacial approaches guided by CAS techniques. Thirteen patients were included in this surgical series. The surgical approach consisted of a lateral rhinotomy combined with a subfrontal craniotomy when necessary. The procedures were planned and assisted by advanced CAS techniques with image fusion of CT and MRI (Medtronic Stealth Station and BrainLAB Vector Vision). Tumors included chordomas, esthesioneuroblastomas, ganglioglioma, and carcinomas (in 1 case associated with an olfactory groove meningioma). Lateral rhinotomy was performed by the ENT surgeon and conjoint tumor removal with dural repair was performed together with the neurosurgeon in all cases. In 4 cases an additional frontal craniotomy was performed. The application of CAS in combined approaches appeared to be safe and reliable for identification of tumor borders or vital structures hidden or encased by the tumors. There was no mortality in our series. A secondary plastic procedure was performed in 2 patients after extensive tumor resection. There were no new permanent neurological deficits. Tumors were either removed completely, or subtotal resection was achieved allowing targeted postoperative radiotherapy. There were 2 tumor recurrences (esthesioneuroblastoma and paranasal squamous cell carcinoma) after total tumor resection and 1 recurrence after subtotal resection of a grade 2 chondrosarcoma.
Productivity Increasing using the Automation Machine for Arranging Wheels into the Finished Goods Rack in a Wheels Assembly Manufacturer

Field: Engineering (Physical Sciences)

The automotive parts manufacturing business has continuously increased market competition. The production costs are always discussed when negotiating prices. (The price of the product is often taken into account in always negotiating with customers) Therefore, manufacturers focus on continuously reducing production costs. To maintain reasonable profits in this research, a method to reduce costs by creating an automation system to replace manual labor in the wheel packaging workstation is presented. Because human labor is one of the main costs in the cost of producing goods. This research was carried out in a wheel assembly plant in the TFD Industrial Estate and after the implementation an automation system for wheel arranging. The company can reduce production costs by reducing the number of employees in the workstation packing for 3 people and can reduce production costs by 522,000 baht per year and increase productivity by 127.84% as well.
Purification and properties of a cross-linked complex between cytochrome c and cytochrome c peroxidase

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Cytochrome c (horse heart) was covalently linked to yeast cytochrome c peroxidase by using the cleavable bifunctional reagent dithiobis-succinimidyl propionate in 5 mM-sodium phosphate buffer, pH 7.0. A cross-linked complex of molecular weight 48 000 was purified in approx. 10% yield from the reaction mixture, which contained 1 mol of cytochrome c and 1 mol of cytochrome c peroxidase/mol. Of the total 40 lysine residues, four to six were blocked by the cross-linking agent. Dithiobis-succinimidylpropionate can also cross-link cytochrome c to ovalbumin, but cytochrome c peroxidase is the preferred partner for cytochrome c in a mixture of the three proteins. The cytochrome c cross-linked to the peroxidase can be rapidly reduced by free cytochrome c-557 from Crithidia oncopelti, and the equilibrium obtained can be used to calculate a mid-point oxidation-reduction potential for the cross-linked cytochrome of 243 mV. Mitochondrial NADH-cytochrome c reductase will reduce the bound cytochrome only very slowly, but the rate of reduction by ascorbate at high ionic strength approaches that for free cytochrome c. Bound cytochrome c reduced by ascorbate can be re-oxidized within 10s by the associated peroxidase in the presence of equimolar H2O2. In the standard peroxidase assay the cross-linked complex shows 40% of the activity of the free peroxidase. Thus the intrinsic ability of each partner in the complex to take part in electron transfer is retained, but the stable association of the two proteins affects access of reductants.
Ideal geometry of periodic entanglements

Field: Mathematics (Physical Sciences)

Three-dimensional entanglements, including knots, knotted graphs, periodic arrays of woven filaments and interpenetrating nets, form an integral part of structure analysis because they influence various physical properties. Ideal embeddings of these entanglements give insight into identification and classification of the geometry and physically relevant configurations in vivo . This paper introduces an algorithm for the tightening of finite, periodic and branched entanglements to a least energy form. Our algorithm draws inspiration from the Shrink-On-No-Overlaps (SONO) (Pieranski 1998 In Ideal knots (eds A Stasiak, V Katritch, LH Kauffman), vol. 19, pp. 20–41.) algorithm for the tightening of knots and links: we call it Periodic-Branched Shrink-On-No-Overlaps (PB-SONO). We reproduce published results for ideal configurations of knots using PB-SONO. We then examine ideal geometry for finite entangled graphs, including θ -graphs and entangled tetrahedron- and cube-graphs. Finally, we compute ideal conformations of periodic weavings and entangled nets. The resulting ideal geometry is intriguing: we see spontaneous symmetrisation in some cases, breaking of symmetry in others, as well as configurations reminiscent of biological and chemical structures in nature.
<title>Image-based dynamic modeling of phase transformation in hybrid SMA</title>

Field: Materials Science (Physical Sciences)

The main interest of this study is to investigate phase transformation behavior in hybrid SMA under moderate dynamic loads. A hybrid SMA is described as a two-component composite made of dense SMA matrix with pores, and a passive or active material that fills the pores. The dynamic behavior of hybrid SMA under strain rates of 1000 /s is investigated by incorporating the porous mesostructure in the finite element analysis. X-ray computed micro tomography (XCMT) images are employed to synthesize statistical information and probabilistic algorithms are utilized in obtaining suitable representative finite element meshes. The effective constitutive response of hybrid SMA is obtained by simulating the split Hopkinson bar test of the finite element specimen. A parametric study based on volume fraction of the filler material is carried out. A comparison of hybrid SMA and porous SMA is also performed.
KINERJA SISTEM AGRIBISNIS USAHA PENGGEMUKAN SAPI DI DESA ADIREJO KECAMATAN TERBANGGI BESAR KABUPATEN LAMPUNG TENGAH (STUDI KASUS DI PT INDO PRIMA BEEF)

Field: Agricultural and Biological Sciences (Life Sciences)

This study aims to analyze the performance of the agribusiness system of the beef cattle fattening business at PT Indo Prima Beef. The research method used is the case study method, located at PT Indo Prima Beef, Terbanggi Besar District of Central Lampung Regency. Data were collected in November-December 2022. Data were analyzed using qualitative and quantitative descriptive analysis. The results showed that the performance of the production facilities supply subsystem was good, as analyzed by the agribusiness index analysis and six right. However, there are still insufficiencies, such as locations close to settlements, feed is not in the right place, and labor is not in the right type, quality, and quantity. The performance of the cultivation subsystem is suitable for cultivation because it has an R/C ratio value of >1, but currently, the company has not conducted mating with artificial insemination. The performance of the marketing subsystem is good as analyzed by the agribusiness index and marketing mix analysis (4P). Beef cattle marketing channels are large traders (abattoirs), retailers, and consumers. The performance of the supporting service subsystem is good, the services utilized by PT Indo Prima Beef are financial institutions, research institutions, government policies, transportation facilities, communication and information technology facilities, and supply stores for production facilities. Overall, the performance of the agribusiness system at PT Indo Prima Beef has been running well with a weighted agribusiness index of 81.51%. Keywords: Agribusiness index, agribusiness system, beef cattle.
User evaluation of a task for shortlisting papers from researcher’s reading list for citing in manuscripts

Field: Computer Science (Physical Sciences)

Purpose Although many interventional approaches have been proposed to address the apparent gap between novices and experts for literature review (LR) search tasks, there have been very few approaches proposed for manuscript preparation (MP) related tasks. The purpose of this paper is to describe a task and an incumbent technique for shortlisting important and unique papers from the reading list (RL) of researchers, meant for citation in a manuscript. Design/methodology/approach A user evaluation study was conducted on the prototype system which was built for supporting the shortlisting papers (SP) task along with two other LR search tasks. A total of 119 researchers who had experience in authoring research papers participated in this study. An online questionnaire was provided to the participants for evaluating the task. Both quantitative and qualitative analyses were performed on the collected evaluation data. Findings Graduate research students prefer this task more than research and academic staff. The evaluation measures relevance, usefulness and certainty were identified as predictors for the output quality measure “good list”. The shortlisting feature and information cues were the preferred aspects while limited data set and rote steps in the study were ascertained as critical aspects from the qualitative feedback of the participants. Originality/value Findings point out that researchers are clearly interested in this novel task of SP from the final RL prepared during LR. This has implications for digital library, academic databases and reference management software where this task can be included to benefit researchers at the manuscript preparatory stage of the research lifecycle.
Distributionally Robust Safety Verification for Markov Decision Processes

Field: Computer Science (Physical Sciences)

In this paper, we propose a distributionally robust safety verification method for Markov decision processes where only an ambiguous transition kernel is available instead of the precise transition kernel. We define the ambiguity set around the nominal distribution by considering a Wasserstein distance. To this end, we introduce a robust safety function to characterize probabilistic safety in the face of uncertain transition probability. First, we obtain an upper bound on the robust safety function in terms of a distributionally robust Q-function. Then, we present a convex program-based distributionally robust Q-iteration algorithm to compute the robust Q-function. By considering a numerical example, we demonstrate our theoretical results.
Entrepreneurship : the case study of Hwa Tat Lee holdings limited

Field: Business, Management and Accounting (Social Sciences)

In recent years, local entrepreneurship has gained considerable attention and interest. With aspiration and determination, an entrepreneur can start up and develop an enterprise, and possibly bring it to the promised land of profits. Moreover, the contribution of entrepreneurship towards the society is without doubt. The encouragement of local entrepreneurship is reflected in a statement made by Senior Minister, Mr. Lee Kuan Yew: "Singaporeans must become more 'venturesome' and develop the entrepreneurial spirit if the country is to stay at the top of the economic league." Straits Times, 6 October 1992
Peroral Cholangioscopy in Choledocho-Duodenostomy – Patients Using the Pediatric Fiberscope

Field: Medicine (Health Sciences)

In patients with wide-open bilio-digestive anastomoses peroral cholangioscopy using the pediatric endoscope GIF-P2 is easily performed. The common bile duct is visualised down to the papilla and up to the distributaries of the hepatic ducts. The instrumentation channel allows mobilisation of incarcerated concretions, extraction of food particles (cholangiophytiasis) and guided biopsy of pathological findings. The experience in 12 patients with this method is promising.
Finding a way through the maze - WRB classification with descriptive soil data

Field: Earth and Planetary Sciences (Physical Sciences)

Huge amounts of soil data are recorded in national databases using national nomenclatures. To use them in international context, they have to be harmonized with an international nomenclature. The World Reference Base for Soil Resources (WRB) provides such a framework. We present our approach to retrieve information from existing soil databases and nomenclatures for classifying the soils according to WRB in the form of graphical algorithms. Our study identifies some general mismatches between typical soil profile database structures and the data requirements for testing the presence or absence of WRB diagnostics. In addition, the difficulties originating e.g. from the data structure for recording horizon-related data, differing cl ass limits in national and FAO soil description systems, and ill- determined rules for soil description have to be addressed for proper identification of WRB diagnostics with existing soil data.
Rapid Prototyping for Functional Electrical Stimulation Control

Field: Health Professions (Health Sciences)

Electrical muscle stimulators can help restore limb function following a neurological injury. However, complex neuromuscular stimulators need a straightforward software interface to simplify hardware programming and make patient care more efficient. The Clinical Set-up Tool integrates fast parameter selection with a user-friendly interface. The system could potentially operate on portable devices, such as mobile phones, increasing its potential for widespread acceptance in the clinical community.
Effect of Channel Noise in Synchronization and Metabolic Energy Consumption in Unidirectionally Coupled Neurons: Drug Blocking of Sodium and Potassium Channels

Field: Neuroscience (Life Sciences)

In this work the stochastic generalization of single Hodgkin-Huxley neuron is further extended to unidirectionally coupled neurons. Our main focus is to elucidate the role of channel noise in the kinetics and energetics of spiking of action potential and the synchronization between two coupled neurons. We have found that the size of the patch is playing the pivotal role in synchronization and metabolic energy consumption. For example, there exists three different patch size ranges in which coupled neuron system behaves in a different manner from noise enhanced phase to dead range state before reaching the deterministic limit. We have also found that the sodium and potassium channel blockers have characteristic kinetic and energetic effects on synchronization process and metabolic energy consumption rate which has been validated with the simulated data.