jimnoneill/paper-to-field-training huggingface dataset:
Abstract A113: Chronic stress promotes lymph node metastasis through beta-adrenergic regulation of lymphangiogenesis

Field: Medicine (Health Sciences)

Abstract Lymphangiogenesis drives breast cancer metastasis to lymph nodes. However, the physiological pathways that regulate lymphangiogenesis and lymph node metastasis are yet to be defined. We have previously shown that chronic stress increased metastasis of primary tumour cells to lymph nodes via beta-adrenergic receptor signaling. Consistent with a critical role for beta-adrenergic signaling in cancer progression, recent clinical studies found that blockade of beta-adrenergic activation protected women with triple negative breast cancer from distant metastasis. To investigate if the beta-adrenergic pathway promotes metastasis by impacting lymphangiogenesis, we explored the effect of restraint stress or pharmacological activation of beta-adrenergic pathways in an orthotopic xenograft model of triple negative breast cancer. To physiologically activate beta-adrenergic signaling, mice were subjected to 2 hours of daily restraint for 7 days prior to tumor cell inoculation and 14 days thereafter. Serial bioluminescence imaging revealed chronic stress reduced time to lymph node metastasis and increased tumor cell load in draining lymph nodes. Stress increased the expression of lymphangiogenic factor VEGF-C and its receptor Vefgr-3 and increased lymphangiogenesis within primary tumors. Pharmacological activation of beta-adrenergic signaling with isoproterenol similarly increased lymphangiogenesis and metastasis. Prostaglandin-mediated dilation of lymphatic collector vessels was recently linked to increased breast cancer metastasis. We found stress increased expression of COX-2, the rate limiting enzyme in prostaglandin production, and increased dilation of lymphatic vessels that link primary tumors to draining lymph nodes. Treatment with COX-2 inhibitor celecoxib reversed stress-induced lymph vessel dilation and similarly blocked stress-enhanced lymph node metastasis and tumor lymphangiogenesis. Together, these data show that beta-adrenergic receptor signalling may be an important effector pathway of stress-enhanced lymphangiogenesis and LN metastasis and that beta-blockade of lymphangiogenesis may be an important mechanism in protecting women with breast cancer from the adverse effects of stress biology. Citation Format: Caroline P. Le, Matthew A. Pimentel, Corina Kim, Cameron J. Nowell, Tara Karnezis, Ming G. Chai, Marco Herald, Steven A. Stacker, Erica K. Sloan. Chronic stress promotes lymph node metastasis through beta-adrenergic regulation of lymphangiogenesis. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications; Oct 3-6, 2013; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Res 2013;11(10 Suppl):Abstract nr A113.
#Civilwar2: Instagram posts during COVID-19

Field: Social Sciences (Social Sciences)

The COVID-19 pandemic uniquely represents an unprecedented health crisis that has permeated all aspects of human society. Given the technological affordances of social media to disseminate fact-based as well as purposefully misinformed and/or conspiratorial information, this paper examines the serious and strategic messaging on Instagram posts tagged with #civilwar2. Results from a critical discourse analysis show that within modern American conspiratorial thinking and given the problematic politicization of COVID-19, healthy scepticism is replaced with conspiracy absent of theory. When extreme political and socio-cultural polarization occurs, this tendency is exacerbated by the bifurcation of meaning as expressed by those who seek to promote a particular angle of a given story or event. While this may be somewhat common in so-called old media, online in discursive spaces such as Instagram, the challenge to understand the mediated message is compounded by visual referents, which are often remixed to include adjunct information, such as mashups, hashtags, inserted text, or images, etc. Results include the identification of two main categories of Instagram memes tagged with #civilwar2. These categories are analysed following three primary characteristics of discourse: genre, discourse/representation, and style.
Aspergillus flavus SUMO Contributes to Fungal Virulence and Toxin Attributes

Field: Immunology and Microbiology (Life Sciences)

Small ubiquitin-like modifiers (SUMOs) can be reversibly attached to target proteins in a process known as SUMOylation, and this process influences several important eukaryotic cell events. However, little is known regarding SUMO or SUMOylation in Aspergillus flavus. Here, we identified a novel member of the SUMO family in A. flavus, AfSumO, and validated the existence of SUMOylation in this pathogenic filamentous fungus. We investigated the roles of AfsumO in A. flavus by determining the effects of AfsumO mutations on the growth phenotype, stress response, conidia and sclerotia production, aflatoxin biosynthesis, and pathogenicity to seeds, and we found that SUMOylation plays a role in fungal virulence and toxin attributes. Taken together, these results not only reveal potential mechanisms of fungal virulence and toxin attributes in A. flavus but also provide a novel approach for promising new control strategies of this fungal pathogen.
Geophysical and Remote Sensing Methods for Groundwater Potential Prediction in a Typical Basement Complex, Nigeria: The Power of GBT Model over AHP-MCDA

Field: Earth and Planetary Sciences (Physical Sciences)

This study evaluates the effectiveness of a machine learning–based Gradient Boosting Tree (GBT) model for predicting groundwater potential and compares its performance with the conventional Analytical Hierarchy Process (AHP) model. Both approaches were applied using twelve groundwater potential predictors (GPPs): Digital Elevation Model (DEM), slope (S), drainage density (Dd), land use (Lu), aquifer resistivity (ρa), aquifer thickness (h), overburden thickness (b), hydraulic conductivity (k), transmissivity (Tr), storativity (St), diffusivity (D), and reflection coefficient (Rc). The GBT model was developed with Salford Predictive Modeler 8.0 using a 90:10 training–testing data split and k-10 cross-validation. Predictor importance was assessed, and the groundwater potentiality prediction index (GPPI) was generated and spatially analyzed in ArcGIS. Groundwater potential maps from both models delineated three zones: low, moderate, and high. The GBT-derived map indicated that low–moderate potential areas covered 56% of the study region, compared to 71% in the AHP-based map. Model validation using water column measurements from fifteen wells, analyzed with Spearman’s correlation, showed higher predictive accuracy for the GBT model (rs = 0.74; p = .002) than for the AHP model (rs = 0.66; p = .007). The results demonstrate that aquifer resistivity alone is inadequate for groundwater evaluation and underscore the importance of integrating multiple parameters. Overall, the GBT model outperformed AHP, establishing itself as a more reliable approach for groundwater potential prediction.
Single Unit Status in Deep Convolutional Neural Network Codes for Face Identification: Sparseness Redefined

Field: Computer Science (Physical Sciences)

Deep convolutional neural networks (DCNNs) trained for face identification develop representations that generalize over variable images, while retaining subject (e.g., gender) and image (e.g., viewpoint) information. Identity, gender, and viewpoint codes were studied at the "neural unit" and ensemble levels of a face-identification network. At the unit level, identification, gender classification, and viewpoint estimation were measured by deleting units to create variably-sized, randomly-sampled subspaces at the top network layer. Identification of 3,531 identities remained high (area under the ROC approximately 1.0) as dimensionality decreased from 512 units to 16 (0.95), 4 (0.80), and 2 (0.72) units. Individual identities separated statistically on every top-layer unit. Cross-unit responses were minimally correlated, indicating that units code non-redundant identity cues. This "distributed" code requires only a sparse, random sample of units to identify faces accurately. Gender classification declined gradually and viewpoint estimation fell steeply as dimensionality decreased. Individual units were weakly predictive of gender and viewpoint, but ensembles proved effective predictors. Therefore, distributed and sparse codes co-exist in the network units to represent different face attributes. At the ensemble level, principal component analysis of face representations showed that identity, gender, and viewpoint information separated into high-dimensional subspaces, ordered by explained variance. Identity, gender, and viewpoint information contributed to all individual unit responses, undercutting a neural tuning analogy for face attributes. Interpretation of neural-like codes from DCNNs, and by analogy, high-level visual codes, cannot be inferred from single unit responses. Instead, "meaning" is encoded by directions in the high-dimensional space.
Jane E. Soothill. Gender, Social Change and Spiritual Power: Charismatic Christianity in Ghana. Leiden and Boston: Brill, 2007. Studies of Religion in Africa series, xii + 261 pp. Notes. Select Bibliography. Index. $99.00. Cloth.

Field: Arts and Humanities (Social Sciences)

Jane E. Soothill. Gender, Social Change and Spiritual Power: Charismatic Christianity in Ghana. Leiden and Boston: Brill, 2007. Studies of Religion in Africa series, xii + 261 pp. Notes. Select Bibliography. Index. $99.00. Cloth. - Volume 51 Issue 2
Education-policy-by-ballot-initiative. Considerations related to democracy and justice

Field: Social Sciences (Social Sciences)

What is the relationship between direct democratic ballot initiatives, democratic deliberation, and justice? When voters collectively make policy decisions, what responsibilities do experts have to contribute to informing public deliberation about the relevant issues? This article investigates how the direct democratic ballot initiative process, increasingly and controversially used in the United States to allow citizens to make education policy decisions, may serve to enhance or constrain democracy and justice. Through the lens of deliberative democratic theory, this article aims at providing greater understanding of the education-policy-by-ballot-initiative phenomenon and bringing to light the possibilities of tyranny of the majority when policies having to do with civil rights are left up to popular vote. It concludes with an argument for researchers to use their expertise in the service of public information and deliberation. (DIPF/Orig.)
Application of total bacteria measuring apparatus for detecting total bacteria in raw milk

Field: Agricultural and Biological Sciences (Life Sciences)

A total bacteria measuring apparatus was developed for detecting total bacteria in raw milk,which overcame the defects of traditional reduction test measured by eyes,and might make a quantitative expression of total bacteria.The apparatus detected continuously the color(RGB)of the milk samples which had been added reagents,and the rate of color change was showed as R slope by statistical analysis.A standard curve was established to show the relation between R slope and total plate count.There was no significant difference between the two results of total bacteria measuring apparatus and standard plate count method.Comparing with flow cytometry,the total bacteria measuring apparatus had some advantages about better relativity with SPC,lower operating cost and more efficiency.
Sion 1840 - Building 42 (LoD-1)

Field: Computer Science (Physical Sciences)

Coordinates: N/A Length: 9.9 mWidth: 10.12 mHeight: 6.45 mVertices: 30 Primitives: 16 The Length, Width, Height, Vertices and Primitives listed above have been derived directly from the OBJ file.Main Files: Filename.obj.glb.xml.mtl0___LoD1__id-42_001.objLink0___LoD1__id-42_001.mtlLink0___LoD1__id-42_001.glbLink11249308_edm.xmlLink11249308_metsmods.xmlLinkThumbnails: Perspective1000x1000512x512256x256128x128Perspective 1LinkLinkLinkLinkPerspective 2LinkLinkLinkLinkPerspective 3LinkLinkLinkLinkPerspective 4LinkLinkLinkLinkPerspective TopLinkLinkLinkLinkChangelog: - v0.0.2: Thumbnails added, Description updated with Link Tables. - v0.0.3: Added XMLs for Europeana Data Model (EDM) and MetsMods.
Prosthetic Rehabilitation of Deeply Placed Implant

Field: Dentistry (Health Sciences)

Abstract Fixed prosthetic option is the most accepted treatment desired by the patient in modern times. Malpositioned implant presents a challenge, especially during prosthetic phase. The prosthetic achievement of various complex cases can be done by following appropriate procedure; one of which has been discussed in this report. The use of transmucosal abutment with castable abutment is successful treatment option for complex malposed single dental implant.
Influence of Nitrogen Supply on the Susceptibility of Wheat to Septoria tritici

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Nitrogen (N) fertilization is required for achieving high yields in wheat ( Triticum aestivum L.) but may enhance the development of Septoria tritici Rob. ex Desm. A study was undertaken to investigate how N supply influences the area under disease progress curve (AUDPC). Two field experiments were carried out in a typical argiudol in 1996 and 1997. Six cultivars were grown at two N treatments (0 and 100–150 kg N/ha) in a split plot design. Percentage of necrosis (severity) of the two upper leaves of each treatment was evaluated three times during the growing season. Height and heading date were also scored and related to the resistance level. In 1996, with weather conditions conducive to the disease, AUDPC values were higher in the fertilized treatment. In 1997, with insufficient rain immediately after inoculation, the disease only progressed faster under N fertilization in the flag leaf, which was exposed to conducive environmental conditions from its appearance. The effect of N fertilization was influenced by the cultivar characteristics, climatic and agronomic conditions. Knowledge that N fertilization promotes the development of S. tritici in conducive conditions will be useful for deciding management strategies of the cultivars and for optimizing conditions for the selection in breeding programmes.
Gazi Üniversitesi hazırlık sınıfı öğrencilerinin öğrenme stilleri.

Field: Social Sciences (Social Sciences)

The purpose of this study was to determine the learning styles of preparatory school students from Gazi University and examine the relationship between students̕ learning style preferences (LSP) and faculty students will study in, gender, proficiency level of English and achievement scores on listening, reading, grammar, and writing in the English Course. The instrument, Index of Learning Styles (ILS), was administered to 367 randomly selected students. As for the data analysis, descriptive statistics portrayed the frequencies, percentages, means and standard deviations, the t test was conducted to see whether students̕ achievement scores differ according to their LSPs and the Crosstabs procedure was conducted to investigate whether the LSPs of the students at Gazi University differ according to faculty they will study in, gender and level of proficiency. The results indicated that there was no significant difference between students̕ LSPs and faculty, gender, level and achievement scores.
Value-at-risk models under basel accord & Europe debt crisis : a Singapore perspective.

Field: Economics, Econometrics and Finance (Social Sciences)

Risk management is an integral factor facilitating global financial stability. Since 1988, the Basel Accord has been setting minimum regulatory capital standards for banks throughout the world based on individual bank’s Value-at-Risk (VaR) forecasts. Adopted by more than 100 countries, including Singapore, the current Basel Accord Market Risk framework is designed to encourage superior risk management by allowing banks to use internal models to calculate the VaR used in the determination of their daily capital requirement. Following the global financial turbulence in 2008-2009 and the debate on limitations of current VaR-based capital requirements, it becomes of paramount importance to search for VaR models which can overcome these limitations, to be used during the recent Europe Debt Crisis. This paper aims to evaluate the VaR forecasting performances of three GARCH specification models implemented on simple portfolios consisting of the Strait Times Index (STI), using five different sample sizes. Other than standard evaluation criteria such as Unconditional Coverage test and Quantile Loss Function, criterion based on minimization of Capital Requirements imposed by the Basel Accord was also considered. Test results showed that the optimal VaR model varies with sample size, nature of data used for estimation and different evaluation criteria. To prevent underestimation of VaR and inadequate capital, EGARCH models with a small sample size (i.e. with the most recent data) are desirable, but to balance against overestimation of VaR and unnecessary capital holding, TGARCH models with sufficiently large sample data are critical. Finally, results based on comparison between capital requirements and quantile losses also shed light on the advantages and limitations of the inclusion of Stressed-VaR in the determination of Basel III Accord Capital Requirement.
Pengaruh Komitmen, Pelatihan dan Kompetensi terhadap Kinerja Karyawan di PT X

Field: Business, Management and Accounting (Social Sciences)

This research aims to know and analyze: (a) organizational commitment, training, competence, and employee performance in the position of Sales Officer and Remedial Officer PT. X, (b) the influence of organizational commitment, training, and competence on employee performance of Sales Officer and Remedial Officer position at PT. X either partially or simultaneously. Research method used in this research is census method. The population in this study is the entire population is used as a sample of 99 people, consisting of 55 people Remedial officers and 44 sales officers. Data analysis technique using path analysis. The results showed that commitment and competence have a significant effect on employee performance, while training does not significantly affect employee performance. Simultaneously organizational commitment, training, and competence have a significant effect on employee performance at PT. X
Spanish riders law and the right to be informed about the algorithm

Field: Social Sciences (Social Sciences)

The Spanish Government has introduced a regulation which establishes: i) the presumption of employment in digital delivery platforms, and ii) the right of workers’ representatives to be informed about the parameters, rules and instructions on which the algorithms that may have an impact on working conditions are based. This article describes the new law and analyses the novelty of this regulation and its expected impact. The main conclusion is that with this law the Spanish legislator is seeking to clarify that the new technological options – digital algorithms and platforms – are simply the means of performing an economic activity and therefore people who render services within their scope should be considered as employees.
Clinical Evaluation of the i-STAT Kaolin Activated Clotting Time (ACT) Test in Different Clinical Settings in a Large Academic Urban Medical Center

Field: Medicine (Health Sciences)

Abstract Historically, it has been difficult for hospitals to change methods for activated clotting time (ACT) testing because of differences in ACT values obtained with different instruments, wide differences in target ranges used in different procedures, and the difficulty of performing crossover studies at the bedside in critical care situations. There are limited published data comparing the i-STAT (Abbott Point of Care, Princeton, NJ) kaolin ACT with the Medtronic ACT Plus (Medtronic, Minneapolis, MN). The i-STAT system can perform ACT testing in addition to testing of a number of critical care analytes and may offer potential advantages over other ACT analyzers. Comparison of ACT values on 121 simultaneous split-sample tests yielded an R2 of 0.88 with i-STAT = 0.79 Medtronic + 72.0. The Pearson correlation was R = 0.94, indicating statistically significant correlation between the 2 methods. Based on this comparison, we were able to implement the i-STAT ACT throughout our institution without changing target ranges for any individual procedure.
THERMODYNAMIC INVESTIGATION OF Ag8GeТe6 AND Ag8GeТe6-xSex SOLID SOLUTIONS BY THE EMF METHOD WITH A SOLID Ag+ Conducting Electrolyte

Field: Chemistry (Physical Sciences)

The thermodynamic properties of Ag8GeTe6 compound and Ag8GeТe6-xSex solid solutions were studied by EMF measurements of the concentration cells concerning to a silver electrode with Ag4RbI5 solid electrolyte in the 300–400 K temperature range. The partial thermodynamic functions of silver in alloys are calculated from the EMF measurements data. Based on the data on solid-phase equilibria in the Ag-Ge-Se-Te system, the potential-forming reactions responsible for these partial molar functions were determined and the standard thermodynamic functions of formation and standard entropies of the Ag8GeТe6 compound and solid solutions of the compositions Ag8GeTe5Se, Ag8GeTe4Se2, Ag8GeTe3Se3, Ag8GeTe2Se4 and Ag8GeTeSe5 were calculated.
Innovative Adaptive Intelligent Scheme for Voltage-Frequency Control in Inverter-based Microgrid

Field: Engineering (Physical Sciences)

In modern power grids, in order to ensure the capability of maintaining balance between supply and demand under violent disturbances, increasing intelligence and flexibility in the optimization and control sides are required. There are several electronic interfaced Distributed Generations (DGs) with local and global control loops in a microgrid. Because of utilization of different DGs and transition between different operation modes, microgrid has dynamic behavior. So, in the case of any contingency, fault occurrence or severe changes in load, the electronic interfaced DGs may be failed in voltage and frequency regulation and the microgrid is collapsed. The conventional PI controllers (with fixed coefficients) are utilized in primary voltage/frequency control units in electronic interfaced DGs control systems. But in the case of severe changes in microgrid load and its operation conditions, the conventional PI controllers may be inadequate and cannot provide desirable performance. In this paper, Adaptive Neuro-Fuzzy Interface System (ANFIS) structure is used for adapting the PI controller coefficients in the primary control level. The developed system based on ANFIS structure has perfect performance and proper response for different conditions.
Patient-centred Medicine in Transition – The Heart of the Matter Bleakley Alan Patient-centred Medicine in Transition – The Heart of the Matter 267pp £117 Springer 9783319024868 3319024868

Field: Health Professions (Health Sciences)

ALAN BLEAKLEY is an academic specialising in communication. He studies healthcare work, especially what he calls ‘an epidemic of medicine’s own making’ – the suffering, missed opportunities and unnecessary work generated when health professionals fail to communicate effectively with patients, with one another and with members of multidisciplinary teams.