jimnoneill/paper-to-field-training huggingface dataset:
Study of Interaction of Human Serum Albumin with Doxorubicin (Anti-Cancer Drug) by Docking Simulation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Human serum albumin (HSA) is one of the main endogenous vehicles for biodistribution of molecules by blood plasma. Association constants and thermodynamic parameters for the interaction of HSA with doxorubicin were studied by docking. Docking study suggests that doxorubicin is able to interact with HSA by means of hydrogen bond with one arginine residue, whereas the hydroxyl group is inserted in a hydrophobic pocket. The estimated of Gibbs free energies (ΔG°) is equal to -9.1 kcal/mol for the best model. The negative values of ΔG° indicate a spontaneous process. The association constant value (Ka ≈ 8×10<sup>3</sup> L.mol<sup>−1</sup>) is favorable for its efficient biodistribution by blood plasma.
Sea-surface temperatures predict targeted visual surveys of octopus abundance

Field: Environmental Science (Physical Sciences)

In upwelling systems around the world, octopus abundance is forecast by marine productivity linked to upwelling strength, often indicated by sea-surface temperatures. Climate change may disrupt populations of marine animals that are linked to such temperature-dependent events. We analysed the relationship of the abundance of giant Pacific octopuses (Enteroctopus dofleini) to Gulf of Alaska and Washington State water temperatures. Abundance was measured in targeted visual surveys in Prince William Sound, Alaska, over the period 1995–2016 and from REEF.org diver surveys in Washington State from 2003 to 2019. Octopus counts from both survey programs had significant negative correlations with water temperatures over the previous 2.5–4 years. Water temperature accounted for from 0.41 to 0.71 of the variance (R2) in octopus abundance in eastern Gulf of Alaska waters located in ocean currents up-stream of the survey areas, and up to 0.81 of the variance in Washington State waters. These negative correlations provide a possible predictive index for octopus abundance as measured by targeted visual surveys. These methods may be useful tools in management of octopuses and indicate impacts of climate change on North Pacific coastal marine ecosystems.
Bifunctional Lewis Acid/Enamine Catalysis of Hetero-Diels-Alder Reaction

Field: Chemistry (Physical Sciences)

The combination of metal Lewis acid catalysis and organocatalysis in one reaction is attractive and may allow entirely new reactions to occur. In this report, a bifunctional catalyst that can chelate with the metal and generate enamine at the same time is introduced to a hetero-Diels-Alder reaction. The excellent efficiency and stereoselectivity nicely demonstrated the utility of such a strategy.
Pengaruh Modal Intelektual dan DPK Terhadap Manajemen Laba dengan ROA sebagai Variabel Intervening

Field: Business, Management and Accounting (Social Sciences)

The purpose of this study is to determine the determinants of earnings management such as intellectual capital, third party funds mediated by Return on Assets (ROA). This study utilizes information taken from the financial reports of banks listed on the IDX by using a purposive sampling test method that meets the exploration steps. The research period is taken for 5 years with the amount of information used is 120 data from 24 banking sub-sector entities. The research method uses Partial Least Square (PLS) with secondary data types. The results of the study show that there is a partially positive influence of intellectual capital and third party funds on return on assets, there is a positive relationship between intellectual capital and earnings management, and there is no relationship between third party funds on earnings management, and there is a negative effect of return on assets on management. profit. Return on assets is able to mediate intellectual capital on earnings management and return on assets is not able to mediate the relationship of third party funds on earnings management.
Growth and Development of the Child with Asthma

Field: Medicine (Health Sciences)

Normal childhood growth is a sensitive indicator of health, and there are fewchronic diseases of childhood that do not adversely affect growth. Several mechanisms of growth suppression appear to be commonly involved in var-ious diseases, although a clear understanding of which mechanisms are mostimportant is still lacking. To evaluate the effects of any chronic disease ongrowth, three important aspects of the condition need to be considered: (1)how the natural history of the disease itself affects growth; (2) how medica-tions required to treat the disease affect growth; (3) the clinical relevance ofthe growth effect-i.e., whether the growth impairment results in merely adelay in the normal tempo of growth with attainment of normal final height, or whether ultimate height is adversely affected.
Phenology and recruitment of Caryocar costaricense (Caryocaceae), an endemic tree species of Southern Central America

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract: Basic aspects of the reproductive biology are largely unknown for most tropical tree species, although they are important elements to understand the impacts of anthropogenic activities as logging and forest fragmentation on these populations. In this study, data are presented on leaf and reproductive phenol-ogy, fruit production and seedling demography of a population of an endemic tree species of Southern Central America, Caryocar costaricense. This species has been affected by selective logging and forest fragmentation of its habitat. Phenology was studied by observation of 15-22 tree crowns during two reproductive periods (2003 and 2005). Circular plots were established around 11 adult trees to count the number of fallen fruits and seedlings during three years (2003, 2004, 2005). Although reproductive phenology is restricted to the short dry season in this species, seed germination occurred year-round. Fruit and seedling production shows a strong inter-individual variation within the study populations, with two large trees producing nearly 50%-70 % of the fruits and seedlings during two years. Most of the seeds that fall beneath the tree crown are covered by litterfall or removed by fauna. We found evidence that many of these seeds become part of a seed bank in the forest floor. Because of the observed reproductive dominance of few large trees in these populations, we propose that selective logging on reproductive trees can severely impact the recruitment of this species. Rev. Biol. Trop. 57
Fast-ion interaction in dense plasmas with two-ion correlation effects

Field: Physics and Astronomy (Physical Sciences)

The analytical and numerical investigations of the slowing-down process of a two-ion system in an electron plasma are developed on the basis of the Vlasov-Poisson equations, with particular emphasis on two-ion correlation effects, and the main results are presented. The analysis is based on the assumption that the velocities of the two ions are the same. The forces acting on the two particles are calculated and their resulting effects are (a) the appearance of an angular momentum aligning or misaligning the interionic vector with respect to the velocity vector and (b) the appearance of a net transverse momentum acting on the ion pair and proportional to the angle between the interionic vector and the beam direction.
Letter to the editors

Field: Medicine (Health Sciences)

Patients undergoing orthotopic liver transplantation (OLT) for such diseases as primary biliary cirrhosis (PBC) or autoimmune hepatitis (AIH) have an immune disorder that predominantly targets the liver.There is no reason to believe that replacement of the target organ would modify that process, except by the concomitant administration of immunosuppressive agents.Hayashi et al 1 have shown a higher incidence of acute cellular rejection (ACR) in patients with AIH and PBC.Similarly, Berlakovich et al 2 reported a 59% incidence of ACR in patients with PBC compared with 38% in patients with alcoholic liver disease (P Ͻ .02).In her series, death from sepsis occurred in 26% of the patients with PBC compared with 11% of the patients with alcoholic liver disease.In a retrospective analysis of liver biopsies performed specifically to rule out ACR, we found ACR in 10 of 57 patients (18%) with alcoholic liver disease compared with 11 of 19 patients (58%) with PBC (P Ͻ .005)or 9 of 12 patients (75%; P Ͻ .005)with primary sclerosing cholangitis (PSC).These findings are not, however, reflected in the National Institute of Diabetes and Digestive and Kidney Diseases database (R.H. Wiesner, personal communication, November 1996).This could be the result of pooling observations from several centers with different diagnostic criteria and different indications for liver biopsy.When we tried to show an association between the incidence of ACR and the percentage of diagnoses reported as PBC, PSC, and AIH using the references reported in our publication, 3 we were able to establish a correlation, although it did not reach statistical significance (P Ͻ .1).This is not surprising because of the inclusion of up to 30% of patients diagnosed as ''other'' in some series and the apparent absence of AIH as a diagnosis from virtually all the publications.Patients who undergo OLT are biologically heterogeneous and may therefore require different immunosuppression postoperatively.As these regimens are re-examined and revised downward, it may be useful to examine the outcome stratified by the diagnosis that led to the need for OLT in the first place.
Recycling of PET and PVC wastes

Field: Chemical Engineering (Physical Sciences)

A method for recycling mixed PET and PVC wastes is described. Glycolysis of PET leads to oligomers that are polycondensed with caprolactone. The obtained diols are extended with hexamethylene diisocyanate. In certain conditions the polyurethanes are totally miscible with PVC, leading to acceptable mechanical characteristics for the blend. A relation between the structure of the polyurethane and miscibility with PVC is described. The mechanical characteristics of the blend depends on the polyurethane chemical structure. © 1998 John Wiley & Sons, Inc. J Appl Polym Sci 69: 657–665, 1998
Hybrid power train characterisation and performance optimisation

Field: Energy (Physical Sciences)

The Flemish bus company De Lijn is always attempting to operate its fleet of buses in an environmentally friendly manner and in maintaining the best fuel economy possible. In this regard, a pilot project was implemented in the city of Leuven, where a hybrid bus is operated. Manufactured by Van Hool, the hybrid bus has a series hybrid power train. The Flemish Department for Natural Resources and Energy called for an assessment of the overall performance. The vehicle was put through a series of test cycles in ZEV-mode and in hybrid mode on a proving ground. An on-the-road emission and fuel consumption measurement system called VOEM instantaneously measures the emissions and fuel consumption of a riding vehicle on-line. This system was expanded to cover hybrid vehicles. The entire range of state of charge was covered. The application of this methodology on proving ground resulted in the development of a model capable of predicting fuel consumption and emissions. The model was validated using data from real traffic conditions and comparing the obtained results with real traffic fuel consumption and emission measurements. refs., tabs., figs.
Analisis Sistem Pengendalian Internal dalam Peningkatan Kualitas Laporan Keuangan

Field: Business, Management and Accounting (Social Sciences)

This research aims to analyze the implementation of the internal control system at PT. Petrokimia Kayaku (Persero), Tbk Tanah Karo Branch, is aware of the suitability of the company's financial statements which have been presented based on PSAK No. standards. 1, and knowing the obstacles faced in implementing an internal control system. This research includes qualitative research with a qualitative descriptive analysis approach. The type of data used is primary data and secondary data which was carried out using interview and documentation techniques. The results of this research show that the company's internal control system is divided into two parts, namely financial audit and operational audit. However, in its implementation there are still several obstacles, namely audit results which are often ignored by company management, communication network problems between the Factory and head office, inadequate infrastructure to the Factory. Another obstacle at the head office is that the Head of SPI no longer has staff because the old staff have resigned so that SPI is not optimal in carrying out audits. Then the implementation of SOPs is not optimal. As well as obstacles in terms of human resource development, namely that the implementation of job training for employees is not carried out periodically so that employees are still constrained in carrying out their duties. In facing these obstacles, the company will always carry out continuous supervision and carry out training for all human resources at PT. Petrokimia Kayaku (Persero), Tbk Tanah Karo Branch so that the existing internal control system can run as well as possible.
A Comparison of Five Methods of Estimating Clean Fleece Weight

Field: Agricultural and Biological Sciences (Life Sciences)

Clean fleece weight obtained by scouring the whole fleece from a total of 139 yearling ewes and 61 yearling rams was compared to (1) the results obtained from scouring small side samples, (2) multiple regression equations predicting clean fleece weight from wool density, body weight, staple length and grease fleece weight, (3) a method described by Neale and McFadden (1954) and (4) the results obtained from a new machine designed by P. E. Neale for estimating clean fleece weight. All methods of estimation appear to be reasonably accurate as shown by the correlation coefficients between whole fleece scouring and each of the four methods described above. These correlations were 0.92., 0.95, 0.87, and 0.87, respectively. It was shown by the multiple correlation coefficients that very little information concerning clean fleece weight is lost in predicting clean fleece weight by the multiple regression method if wool density and body weight were omitted from these equations. The small increase in accuracy of the small sample and multiple regression methods over the machine method does not compensate for the saving of time and expense involved as the machine method requires less than 2 min. per fleece for the estimate. The machine requires no technical skill or knowledge for its operation and is applicable to all flocks. Also, the clean fleece weight estimate derived from the machine is independent of all other traits.
Effective-mass Klein-Gordon Equation for non-PT/non-Hermitian Generalized Morse Potential

Field: Physics and Astronomy (Physical Sciences)

The one-dimensional effective-mass Klein-Gordon equation for the real, and non-\textrm{PT}-symmetric/non-Hermitian generalized Morse potential is solved by taking a series expansion for the wave function. The energy eigenvalues, and the corresponding eigenfunctions are obtained. They are also calculated for the constant mass case.
The Upcoming Reform of the Judicial System of the European Union

Field: Social Sciences (Social Sciences)

АнотаціяНаближається реформа судової системи Європейського СоюзуВернер Міґель КюнДоктор юридичних наук Кільський університет імені Крістіана Альбрехта. Провідний юрист у Суді Європейського Союзу. Кіль, НімеччинаСуд Європейського Союзу (СЄС) звернувся з ініціативою внести зміни до свого статуту, щоб вирішити проблеми, пов'язані зі зростаючим робочим навантаженням. Метою реформи є переосмислення юрисдикції судів ЄС з тим, щоб забезпечити їм можливість виконання завдань, покладених на них авторами Договорів у статті 19(1) Договору про Європейський Союз (ДЄС), а саме: забезпечити в розумні строки "дотримання права при тлумаченні та застосуванні Договорів". Реформа безпосередньо передбачає часткову передачу повноважень з тлумачення Загальному суду ("ЗС") у поєднанні з повноваженнями СЄС самостійно розглядати справи, що мають особливе значення. Крім того, можливість подачі апеляції до СЄС повинна бути обмежена, якщо юридичний перегляд справи вже відбувся в першій інстанції апеляційними радами органів ЄС. Низка запобіжних заходів повинна допомогти уникнути ситуації, за якої розподіл навантаження між двома окремими судовими органами може негативно вплинути на уніфікацію та узгодженість судової практики. Ключові слова: Суд Європейського Союзу, Суд загальної юрисдикції, завантаженість судів, перерозподіл юрисдикції, узгодженість прецедентного права
Phase II study of a fixed dose-rate infusion of gemcitabine associated to cisplatin and UFT in advanced carcinoma of the pancreas, an ONCOPAZ study

Field: Medicine (Health Sciences)

4099 Background. The efficacy of gemcitabine can be improved by using a fixed dose-rate infusion. Our objective was to evaluate the efficacy and toxicity of a fixed dose-rate infusion of gemcitabine associated to cisplatin and UFT in patients with advanced adenocarcinoma of the pancreas. Patients and method. From May 2002 to September 2003, 46 chemotherapy-naïve patients were included, median age 57 years (range 27–77), male/female 30/16. Eleven patients (24%) had locally advanced disease and thirty-five (76%) distant metastases. The Karnofsky score was 80–100 in 34 (74%) and 60–70 in 12 (26%). Treatment consisted of gemcitabine 1200 mg/m2 given as a 120-minute infusion weekly for three consecutive weeks, cisplatin 50 mg/m2 on day 1 and oral UFT 400 mg/m2/day (in 2–3 daily doses) on days 1 to 21. Cycles were given every 28 days. Results. A total of 170 cycles of chemotherapy were delivered with a median of four per patient (range 1–11). There were fourteen partial responses (30%, 95%CI:19–48%), 17patients had stable disease (37%), and fifteen had a progression (33%). The median time to progression was five months and the median overall survival was nine months. Among 33 patients evaluable for clinical benefit, eighteen (55%) experienced a clinical benefit response. Grade 3–4 WHO toxicities per patient were as follows: neutropenia in twenty-six patients (57%), thrombocytopenia in fifteen (33%), anaemia in six (13%), diarrhoea in five (11%), nausea/vomiting in 6 (13%) and asthenia in two (4%). There were no toxic deaths. Conclusion. A fixed dose-rate infusion of gemcitabine associated to cisplatin and UFT is active in patients with advanced carcinoma of the pancreas, although at the cost of considerable toxicity. No significant financial relationships to disclose.
Laser direct writing of submicron lines using micro- and nanofiber pens

Field: Engineering (Physical Sciences)

In this paper, a novel direct writing technique using micro- and nanofiber pens is presented. The micro- and nanofiber pen serves as a tightly confined point source and it adopts micro touch mode in the process of writing. The energy distribution of direct writing model is analyzed by Three-Dimension Finite-Difference Time-Domain method. The lines with feature sizes down to 100 nm are experimentally achieved by this technique. Experiments also demonstrate that direct writing using micro- and nanofiber pens has some advantages: simple process, large writing area, and controllable width of lines. In addition, by altering writing direction of lines, complex submicron patterns can be fabricated.
New material for solar cells

Field: Materials Science (Physical Sciences)

With the increase in the usage of resources, the emphasis and focus is to either reduce the consumption of non-renewable resources or to look for alternative sources which are easy to produce and pollution-free. These alternative sources must be preferably cheaper and easy to make. For this project, we are focusing on blending organic compounds with nano-particles in solar cells. Although this idea is new, this can be a much economical and effective way of reducing or divert the usage of non-renewable resources. We will be exploring the ways to obtain these organic compounds that can be used in solar cells. The organic compounds that can be used are sent for other tests, such as their mechanical properties, to find out whether the organic compounds are versatile enough to be used in other electronics. We will be using TGA and DSC to do all these primary tests. For this project, we will be separating into two different parts and in this report; the emphasis is on obtaining the highest yield for pure specimens to be sent for further reactions and identifying possible ways to increase yield percentage.
[Cerebral thrombophlebitis disclosing Behçet disease. Value of high resolution MRI].

Field: Medicine (Health Sciences)

A 21-year-old male of Moroccan descent was admitted for inflammatory polyarthralgia and monoarthritis of the left knee. The patient reported a history of recurrent isolated aphthous ulcerations of the oral cavity. He was found to be positive for the HLA B5 antigen. The other investigations for Behçet's disease were negative. During hospitalization, headache responsible for insomnia developed. Neurologic evaluation was normal, as well as funduscopy and spinal tap findings. CT scan images were suggestive of cerebral thrombophlebitis. Magnetic resonance imaging (MRI) disclosed an old thrombosis of the right transverse sinus. Time-of-flight MRI (MRI with sequences adapted to the study of vessels) evidenced recent thrombophlebitis of the left transverse sinus. Cerebral angiography fully confirmed MRI findings. Treatment with a corticosteroid and an anticoagulant was successful. Final diagnosis was Behçet's disease. Subsequently, the patient developed additional features of the disease, including hypersensitivity to pinprick, retinal vasculitis, and erythema nodosum. This case is interesting for two reasons: cerebral thrombophlebitis in Behçet's disease can manifest as localized headache. It occurs in 6 to 13% of patients. Early diagnosis and treatment are essential; MRI features of cerebral thrombophlebitis were confirmed by the cerebral angiogram. MRI established that the thrombophlebitis was of recent onset. MRI may be appropriate as the initial investigation in patients with suspected cerebral thrombophlebitis.
The Routledge Companion to Puppetry and Material Performance. Edited by Dassia N. Posner, Claudia Orenstein, and John Bell. London: Routledge, 2014; 352 pp.; illustrations. $205.00 cloth, $49.95 paper, e-book available

Field: Arts and Humanities (Social Sciences)

March 01 2016 The Routledge Companion to Puppetry and Material Performance. Edited by Dassia N. Posner, Claudia Orenstein, and John Bell. London: Routledge, 2014; 352 pp.; illustrations. $205.00 cloth, $49.95 paper, e-book available Kee-Yoon Nahm Kee-Yoon Nahm Search for other works by this author on: This Site Google Scholar Author and Article Information Kee-Yoon Nahm Online Issn: 1531-4715 Print Issn: 1054-2043 ©2016 New York University and the Massachusetts Institute of Technology2016 TDR/The Drama Review (2016) 60 (1 (229)): 173–175. https://doi.org/10.1162/DRAM_r_00533 Cite Icon Cite Permissions Share Icon Share Facebook Twitter LinkedIn MailTo Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation Kee-Yoon Nahm; The Routledge Companion to Puppetry and Material Performance. Edited by Dassia N. Posner, Claudia Orenstein, and John Bell. London: Routledge, 2014; 352 pp.; illustrations. $205.00 cloth, $49.95 paper, e-book available. TDR/The Drama Review 2016; 60: 1 (229), 173–175. doi: https://doi.org/10.1162/DRAM_r_00533 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsTDR/The Drama Review Search Advanced Search This content is only available as a PDF. ©2016 New York University and the Massachusetts Institute of Technology2016 Article PDF first page preview Close Modal You do not currently have access to this content.