jimnoneill/paper-to-field-training huggingface dataset:
Data from A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<div><p>The FOXA1 pioneer factor is an essential mediator of steroid receptor function in multiple hormone-dependent cancers, including breast and prostate cancers, enabling nuclear receptors such as estrogen receptor (ER) and androgen receptor (AR) to activate lineage-specific growth programs. FOXA1 is also highly expressed in non–small cell lung cancer (NSCLC), but whether and how it regulates tumor growth in this context is not known. Analyzing data from loss-of-function screens, we identified a subset of NSCLC tumor lines where proliferation is FOXA1 dependent. Using rapid immunoprecipitation and mass spectrometry of endogenous protein, we identified chromatin-localized interactions between FOXA1 and glucocorticoid receptor (GR) in these tumor cells. Knockdown of GR inhibited proliferation of FOXA1-dependent, but not FOXA1-independent NSCLC cells. In these FOXA1-dependent models, FOXA1 and GR cooperate to regulate gene targets involved in EGF signaling and G<sub>1</sub>–S cell-cycle progression. To investigate the therapeutic potential for targeting this complex, we examined the effects of highly selective inhibitors of the GR ligand-binding pocket and found that GR antagonism with ORIC-101 suppressed FOXA1/GR target expression, activation of EGF signaling, entry into the S-phase, and attendant proliferation <i>in vitro</i> and <i>in vivo</i>. Taken together, our findings point to a subset of NSCLCs harboring a dependence on the FOXA1/GR growth program and provide rationale for its therapeutic targeting.</p>Significance:<p>NSCLC is the leading cause of cancer deaths worldwide. There is a need to identify novel druggable dependencies. We identify a subset of NSCLCs dependent on FOXA1-GR and sensitive to GR antagonism.</p></div>
Evaluation of Three-Axis Magnetic Loop Antenna Cross Coupling for Low-Frequency Measurements

Field: Engineering (Physical Sciences)

Nowadays the majority of electrical devices are complex systems with different operation modes and switching elements. The amount of evaluation procedures that are needed to be done for these devices increases drastically. It is pushing standard radiated EMI measurements to the edge, where the advantage between time and the accuracy of measurements should be chosen. Standard low-frequency measurements as CISPR 36, used to evaluate radiated EMI for frequencies below 30 MHz, became too time-consuming and expensive. Proposed improvements which include time-domain multichannel measurements in combination with a three-axis shielded loop antenna can be more time-efficient. Compared to a conventional single-loop antenna, one of the potential challenges is the coupling between loops for the two- and three-axis antenna. This paper investigates the effect of coupling between the individual loops when illuminated with a complex field, which is shown to be the worst-case scenario. Only some minor coupling is observed implying that such a three-axis loop antenna can be used without sacrificing much accuracy, while still providing a significant improvement in the measurement time-efficiency.
Determination of Residual Erythromycin Antibiotic in Fishery Products by Liquid Chromatography-electrospray Ionization Mass Spectrometry

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

A simple and sensitive method for erythromycin quantification by liquid chromatography electrospray mass spectrometry (LC-MS/MS) in fishery products was developed. Samples were extracted by liquid-liquid extraction using 70% acetonitrile. Lipids were removed by acetonitrile saturated hexane. LC separation was performed on a Shiseido UG C-18 column ($150\;mm{\times}2.0\;mm$ internal diameter.) with a gradient system of 0.2% acetic acid-acetonitrile containing 0.2% acetic acid as a mobile phase at flow rate of 0.2 mL/min. The mass spectrometer was operated in selected reaction monitoring with positive electro-spray interface. Transitions were monitored a m/z $734{\to}577$ and $734{\to}158$, with m/z $734{\to}577$ chosen for quantification. Recovery of erythromycin from fish and shrimp fortified at the 10 ng/mL, 50 ng/mL and 100 ng/mL were 91.6-109.4%, 84.4-111.2% and 98.8-109.6% with high precision, respectively. Limits of quantification and limits of detection of erythromycin in both fish and shrimp were 10.0 ng/mL and 1.0 ng/mL, respectively. This analysis method for erythromycin has been proposed for registration in the Korean Official Methods of Food Analysis and has been utilized for fishery products analysis by the Korea Food and Drug Adminstration and the National Fisheries Products Quality Inspection Service.
Mapping the Blogosphere with RSS-Feeds

Field: Computer Science (Physical Sciences)

The massive adoption of social media has provided new ways for individuals to express their opinions online. The blogosphere, an inherent part of this trend, contains a vast array of information about a variety of topics. It is thus a huge think tank that creates an enormous and ever-changing archive of open source intelligence. Modeling and mining this vast pool of data to extract, exploit and describe meaningful knowledge in order to leverage (content-related) structures and dynamics of emerging networks within the blogosphere is the higher-level aim of the research presented here. This paper focuses on this project's initial phase, in which the above-mentioned data of interest needs to be collected and made available offline for further analyses. Our proprietary development of a tailor-made feed-crawler meets exactly this need. The main concept, the techniques and the implementation details of the crawler thus form the main interest of this paper and furthermore provide the basis for future project phases.
Brilliant Result Assure On 304-200 PDF Dumps 2022

Field: Computer Science (Physical Sciences)

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Glutamate Mutase

Field: Chemistry (Physical Sciences)

This chapter contains sections titled: Introduction The Role of Mutß in the Glutamate Mutase Reaction Investigation of the Cobalt-Histidine-Aspartate 'Triad' Is There a Protein Radical Intermediate in the Glutamate Mutase Reaction? Kinetics of Coenzyme Cleavage by Glutamate Mutase
Supplemental Information Nanog Overcomes Reprogramming Barriers and Induces Pluripotency in Minimal Conditions

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

(A) Chimaeric mouse obtained after injecting 2i-iPS cells derived from NS-OKM pre-iPS clone 1 in C57/BL6 blastocysts. Agouti coat color indicates chimaeric contribution (MF1/129 background). Contribution to adult mice with germ-line transmission was previously shown for 2i-iPS cells derived from MEF-OKMS pre-iPS clone 1 [1]. (B) Serial flow cytometric purification for Oct4-GFP reporter activity in pre-iPS cells cultured in serum/LIF. (C) Quantitative real time PCR (qRT-PCR) analysis of retroviral transgene and endogenous pluripotency gene expression in pre-iPS cells positive for the Oct4-GFP reporter. Error bars indicate the range of fold change relative to the sample with highest expression. (D) Bisulfite sequencing analysis of DNA methylation in the Nanog promoter region in MEFderived pre-iPS cells (cl1) positive for the Oct4-GFP reporter. The percentage of methylated CpG sites is indicated above each methylation panel. (E) (Left) Quantification of Oct4-GFP reporter activity during 2i/LIF treatment of NS-OKM clone 1 pre-iPS cells, as measured by flow cytometry. (Right) Time-course qRT-PCR analysis of Fgf4 and Nanog expression during 2i/LIF treatment of NS-OKM clone 1 pre-iPS cells. Error
Differential substrate use in EGF‐ and oncogenic KRAS‐stimulated human mammary epithelial cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Many metabolic phenotypes in cancer cells are also characteristic of proliferating nontransformed mammalian cells, and attempts to distinguish between phenotypes resulting from oncogenic perturbation from those associated with increased proliferation are limited. Here, we examined the extent to which metabolic changes corresponding to oncogenic KRAS expression differed from those corresponding to epidermal growth factor (EGF)‐driven proliferation in human mammary epithelial cells (HMECs). Removal of EGF from culture medium reduced growth rates and glucose/glutamine consumption in control HMECs despite limited changes in respiration and fatty acid synthesis, while the relative contribution of branched‐chain amino acids to the TCA cycle and lipogenesis increased in the near‐quiescent conditions. Most metabolic phenotypes measured in HMECs expressing mutant KRAS were similar to those observed in EGF‐stimulated control HMECs that were growing at comparable rates. However, glucose and glutamine consumption as well as lactate and glutamate production were lower in KRAS‐expressing cells cultured in media without added EGF, and these changes correlated with reduced sensitivity to GLUT1 inhibitor and phenformin treatment. Our results demonstrate the strong dependence of metabolic behavior on growth rate and provide a model to distinguish the metabolic influences of oncogenic mutations and nononcogenic growth.
Unveiling the Dynamics of Consumer Attention: A Two-Stage Hybrid MCDM Analysis of Key Factors and Interrelationships in Influencer Marketing

Field: Business, Management and Accounting (Social Sciences)

In recent years, influencer marketing has taken over traditional brand advertisements on social media platforms, combining word-of-mouth marketing with celebrity endorsements. However, there has been limited academic research on the key success factors in influencer marketing. This paper used a hybrid MCDM model that integrates the Delphi method and the decision-making trial and evaluation laboratory (DEMATEL) approach. Through a two-stage empirical study, the research aims to explore the crucial success factors in influencer marketing. This study focuses on the Taiwanese market. The target respondents for the survey are consumers in Taiwan who have purchased products or services based on recommendations from key opinion leaders (KOLs) or internet celebrities. This systematic research framework not only pinpoints key factors that capture consumer attention towards influencers, but it also illustrates the inter-relationship of structure and improvement directions among these factors. According to results, the key factors include influencer reputation, credibility, degree of key opinion influence, attractiveness, popularity, consistency between influencers and brands, fan engagement level, and informativeness. Finally, businesses can consider five aspects to be the purpose of collaboration, product type, target audience for the product, characteristics of the influencer’s creative content, and media attributes. By comprehensively considering these aspects, businesses can determine the appropriate format for collaborative content. This decision can then guide how influencers communicate with consumers, effectively conveying brand information to the relevant target audience. The research findings provide fresh and significant insights in the field of influencer marketing studies.
Suppression of the Immune Response by Synthetic Adjuvants.

Field: Immunology and Microbiology (Life Sciences)

Two classes of synthetic immunoadjuvants, the muramyl di-peptides, and the polyribonucleotide complexes, have the capacity to either elevate or suppress the immune response depending on the time of their administration relative to antigen. The long term objectives of this contract are to define the cell and molecular signals associated with the in vivo suppression of the immune response of Balb mice by each of these classes of non-toxic adjuvants.
Uganda Malaise trapping 2014–2015 Rhyssinae taxonomy data

Field: Agricultural and Biological Sciences (Life Sciences)

This dataset contains the data and scripts of our paper on the taxonomy of African Rhyssinae. We collected rhyssines by Malaise trapping and hand-netting in tropical forest in Kibale National Park 2014–2015. The dataset contains data on the 456 rhyssines we caught and 13 other African specimens we examined, a table of diagnostic characters, and scripts for generating an identification key and automating the writing of species descriptions. It also contains images used to take measurements of the rhyssines.
The specimen data (1 Specimen data) and table of diagnostic characters (Uganda Rhyssinae diagnosis characters.csv) will usually be of the greatest interest.
CRISPR-Cas9 Knockout Screens Identify DNA Damage Response Pathways and BTK as Essential for Cisplatin Response in Diffuse Large B-Cell Lymphoma

Field: Medicine (Health Sciences)

The recurrence of diffuse large B-cell lymphoma (DLBCL) has been observed in 40% of cases. The standard of care for refractory/relapsed DLBCL (RR-DLBCL) is platinum-based treatment prior to autologous stem cell transplantation; however, the prognosis for RR-DLBCL patients remains poor. Thus, to identify genes affecting the cisplatin response in DLBCL, cisplatin-based whole-genome CRISPR-Cas9 knockout screens were performed in this study. We discovered DNA damage response (DDR) pathways as enriched among identified sensitizing CRISPR-mediated gene knockouts. In line, the knockout of the nucleotide excision repair genes XPA and ERCC6 sensitized DLBCL cells to platinum drugs irrespective of proliferation rate, thus documenting DDR as essential for cisplatin sensitivity in DLBCL. Functional analysis revealed that the loss of XPA and ERCC6 increased DNA damage levels and altered cell cycle distribution. Interestingly, we also identified BTK, which is involved in B-cell receptor signaling, to affect cisplatin response. The knockout of BTK increased cisplatin sensitivity in DLBCL cells, and combinatory drug screens revealed a synergistic effect of the BTK inhibitor, ibrutinib, with platinum drugs at low concentrations. Applying local and external DLBCL cohorts, we addressed the clinical relevance of the genes identified in the CRISPR screens. BTK was among the most frequently mutated genes with a frequency of 3–5%, and XPA and ERCC6 were also mutated, albeit at lower frequencies. Furthermore, 27–54% of diagnostic DLBCL samples had mutations in pathways that can sensitize cells to cisplatin. In conclusion, this study shows that XPA and ERCC6, in addition to BTK, are essential for the response to platinum-based drugs in DLBCL.
Clinical characteristics and laparoscopic surgical outcomes of ovarian dermoid cysts complicated by spontaneous rupture: nine cases and a literature review

Field: Medicine (Health Sciences)

Objective To clarify the clinical characteristics and laparoscopic surgical outcomes of dermoid cysts complicated by spontaneous rupture. Methods This was a single-center retrospective observational study of patients with dermoid cysts treated between January 2005 and December 2021. Results Among 1205 cases of dermoid cysts, spontaneous rupture occurred in nine and torsion occurred in 83 cases. No obvious triggers for rupture were identified, except for one postpartum case with fundal uterine pressure maneuver. Rupture was identified by computed tomography (CT) in six cases. Patients with ruptured cysts had significantly higher serum C-reactive protein (CRP), cancer antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), and squamous cell carcinoma antigen (SCC) levels compared with patients with uncomplicated dermoid cysts or cysts with torsion. Laparoscopic management was possible except for one case with severe adhesion, which required laparotomy. Two patients required prolonged postoperative administration of antibiotics due to refractory chemical peritonitis. Conclusion Combined use of CT imaging and elevated levels of CRP, CA125, CA19-9, and SCC may help to differentiate cyst rupture from torsion. Laparoscopic surgery may be a feasible option; however, prompt laparotomic conversion should be considered in cases with difficult adhesiolysis. Refractory chemical peritonitis may occur after successful surgical management.
Considering People with Dementia and Their Caregivers in Covid‐19 Lockdowns

Field: Health Professions (Health Sciences)

Abstract Recent outbreaks in Australia and the detection of more virulent SARS‐CoV‐2 strains suggest that Covid‐19 is not yet over. In July 2021, three states in Australia were in lockdown as a result of community transmission of the Delta variant. Despite being effective at mitigating outbreaks, lockdowns could have adverse effects on the elderly and people with dementia. This commentary reviews general lockdown and aged‐care lockdown policies in Victoria, New South Wales, and South Australia and highlights how these could affect the well‐being of people with dementia and their caregivers. Drawing from literature on Covid‐19 and dementia, this commentary provides pragmatic recommendations on how to consider the well‐being of people with dementia and their care providers in Covid‐19 management policies .
CARMEN: A Cognitively Assistive Robot for Personalized Neurorehabilitation at Home

Field: Health Professions (Health Sciences)

Cognitively assistive robots (CARs) have great potential to extend the reach of clinical interventions to the home. Due to the wide variety of cognitive abilities and rehabilitation goals, these systems must be flexible to support rapid and accurate implementation of intervention content that is grounded in existing clinical practice. To this end, we detail the system architecture of CARMEN (Cognitively Assistive Robot for Motivation and Neurorehabilitation), a flexible robot system we developed in collaboration with our key stakeholders: clinicians and people with mild cognitive impairment (PwMCI). We implemented a well-validated compensatory cognitive training (CCT) intervention on CARMEN, which it autonomously delivers to PwMCI. We deployed CARMEN in the homes of these stakeholders to evaluate and gain initial feedback on the system. We found that CARMEN gave participants confidence to use cognitive strategies in their everyday life, and participants saw opportunities for CARMEN to exhibit greater levels of autonomy or be used for other applications. Furthermore, elements of CARMEN are open source to support flexible home-deployed robots. Thus, CARMEN will enable the HRI community to deploy quality interventions to robots, ultimately increasing their accessibility and extensibility.
Introduction

Field: Arts and Humanities (Social Sciences)

The materials translated in this issue all derive from 1979, the most crucial year of China's seemingly short-lived "democracy movement." All the materials concern the case of "Li Yizhe," the pen name used by three former Red Guards who had been affiliated with the "Rebel" (Red Flag) faction in Guangzhou during the Cultural Revolution. A fourth, older member of the group was a Party cadre affiliated with Radio Guangzhou. The members of the group were (Li) Zhengtian, now thirty-five, a graduate of the Guangzhou Institute of Fine Arts, and presently an instructor there; Chen (Yi)yang, thirty-four, a graduate of Guangzhou No. 17 Middle School, and presently a worker; Wang Xi(zhe), thirty-two, also a graduate of No. 17 Middle School and a worker; and Guo Hongzhi, fifty-two, the cadre referred to above. Although the group encompassed others at various times, and hundreds suffered when Li Yizhe was officially characterized as a "counterrevolutionary clique" in the mid-1970s, in this introduction the Li Yizhe group will normally refer to the four individuals mentioned above.
Detection of Turned Features in an Autonomous Manner

Field: Computer Science (Physical Sciences)

Automatic feature recognition (AFR) is a crucial process in manufacturing, aiming to extract and interpret design information without human intervention. Leveraging the “Java2” programming language, a software package equipped with Java Advanced Imaging (JAI) capabilities has been developed for this purpose. This package consists of four main modules. The first module is responsible for extracting geometrical data from the source material. Subsequently, the second module utilizes this extracted data to identify machine-turned features. Following identification, the third module generates process plans based on the recognized features. Finally, the fourth module employs these process plans to generate NC (numerical control) part programs. Through this systematic approach, AFR streamlines the machining process, reducing the reliance on manual intervention and enhancing efficiency in manufacturing operations.