jimnoneill/paper-to-field-training huggingface dataset:
Contemporary Percutaneous Coronary Intervention Versus Balloon Angioplasty for Multivessel Coronary Artery Disease

Field: Medicine (Health Sciences)

Background— This investigation compares the results of contemporary percutaneous coronary intervention (PCI) with standard balloon angioplasty among patients with multivessel coronary disease. Patients having balloon angioplasty in the Bypass Angioplasty Revascularization Investigation (BARI) and those within the Dynamic Registry meeting BARI eligibility criteria were studied. Methods and Results— Clinical features and in-hospital and 1-year outcomes of 857 BARI-eligible patients in the Dynamic Registry (contemporary PCI) were compared with the 904 randomized patients who underwent percutaneous transluminal coronary angioplasty in BARI. Compared with BARI patients, Registry patients had fewer lesions attempted (1.53 versus 2.56, P =0.001), more frequent single-vessel PCI (76% versus 33%, P <0.001), greater use of intracoronary stents (76% versus 1%, P <0.001), and GP IIb/IIIa receptor antagonist (24% versus 0%, P <0.001). Angiographic success was achieved more often among Registry patients (91% versus 72%, P <0.001), whereas abrupt closure (1.5% versus 9.5%, P <0.001) and in-hospital coronary artery bypass graft (CABG) (1.9% versus 10.2%, P <0.001) and myocardial infarction (0.8% versus 2.1%, P =0.025) were less common. No differences were observed in either in-hospital or 1-year death, but 1-year death/myocardial infarction was lower in the Registry. Registry patients had lower 1-year rates of subsequent CABG (8.6% versus 22.7%, P <0.001) and PCI (12.4% versus 22.5%, P <0.001). By multivariate analysis, contemporary PCI was independently associated with reduced risk for in-hospital CABG, 1-year CABG, and 1-year PCI. Conclusions— Among patients with multivessel disease, contemporary PCI resulted in safer and more durable revascularization. These results support the role of PCI for selected patients with multivessel coronary artery disease.
Constituent Analysis and Quality Evaluation of Epimedii Folium from Different Species

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Epimedii Folium (EF) is a commonly used traditional Chinese drug that includes many species. In Chinese Pharmacopoeia (2020 edition), EF includes Epimedium brevicornu Maxim, E. Sagittatum (Sieb. et Zucc) Maxim, E. pubescens Maxim, E. koreanum Nakai, and Epimedium Wushanense T.S. Ying. It has been reported that the active constituents in EF are different, resulting in the uneven quality of commercial medicinal materials. To explore the specific differences and make a comprehensive quality evaluation of EF, we established an analytical method to simultaneously detect 45 constituents including 23 flavonoids, 4 phenolic acids, 12 amino acids, 5 nucleosides, and 1 alkaloid in 5 species of EF, based on ultrafast performance liquid chromatography coupled with triple quadrupole-linear ion trap mass spectrometry (UFLC-QTRAP-MS/MS). In addition, orthogonal partial least squares discriminant analysis (OPLS-DA), analysis of variance (ANOVA), and grey correlation analysis (GRA) were used to discriminate and evaluate different species of samples. The results showed that EF could be divided into three categories and EBM was superior to the other four species. This study provides data basis for the comprehensive evaluation and a new perspective on the quality control of EF from different species.
Evaluating omnipolar configuration for complex fractionated atrial electrograms detection: a study in animal models

Field: Medicine (Health Sciences)

Abstract Introduction Atrial fibrillation (AF) is a global health concern, often treated with the ablation of certain tissue areas. The emergence of complex fractionated atrial electrograms (CFAEs) as a biomarker, associated with factors such as fibrosis, anisotropy or heterogeneous tissue activation, initially demonstrated high efficacy [1]. However, subsequent findings have shown variable results. Purpose This study aims to revalidate the criterion for detecting regions with CFAEs using omnipolar electrograms (oEGMs) and to compare this configuration with the traditional bipolar approach, which, due to its sensitivity to the direction of propagation, may yield low-amplitude and prolonged pulses that can be misinterpreted as CFAEs. Methods The data was collected from the left atrium of a female swine using a HD-Grid catheter (Figure 1). To assess the false-positive rate for both configurations, pre-ablated tissue was used. For this reason, the entire dataset of 400 recordings was filtered based on peak-to-peak amplitude (&gt; 1.5 mV) and vector field heterogeneity [2] (VFH &lt; 0.4). Thus, characterization was performed solely on healthy tissue. A total of 2666 bEGMs and their respective 1333 oEGMs were analyzed. For oEGMs acquisition, the bEGM cross approach was used [3]. A cross-correlation algorithm was then employed to classify each complex into distinct groups. This algorithm groups pulses based on a maximum cross-correlation greater than 0.95. Following the criteria for defining fractionation [1], each group was classified into one of two categories: normal or CFAE. Results Table 1 summarizes the results of the cross-correlation algorithm results obtained. The percentage of false positives for CFAEs identified in bEGMs (13.15%) is significantly higher than in oEGMs (3.32%), whose principle of amplitude maximization in the direction of propagation suppresses fractionation succesfully. Furthermore, the amplitude and duration ranges of the bEGMs confirms the initial hypothesis that low-amplitude and prolonged bEGMs are prone to misclassification as CFAEs. Examples of pulses from each high cross-correlation group illustrate accurate classification. Note that CFAE pulses exhibit a greater number of baseline-deflecting peaks and display a more complex morphology. Conclusions This study reports the limitations of bipolar configuration in identifying CFAE, particularly due to its sensitivity to propagation direction when classifying entirely healthy pulses. The omnipolar approach is proposed as it significantly enhances CFAE identification by reducing false positives fourfold, and providing a robust technique for assessing cardiac substrate in detecting ablation-suitable regions in AF patients.Figure 1:HD-Grid intracavitary catheter Table 1:Summary of the results
A Micromechanics-based Ductile Damage Model Incorporating Plastic Anisotropy and Void Shape Effects

Field: Materials Science (Physical Sciences)

The development of improved ductile damage models for plastically anisotropic materials has received limited attention in the literature. We derive a new yield criterion for materials containing spheroidal voids embedded in a Hilltype orthotropic matrix. The coupling of void shape evolution with the plastic anisotropy of the matrix leads to improved predictions for the yield surface as well as the evolution of microstructural variables. An alternative numerical approach is also developed to derive rigorous upper-bounds to the yield loci for anisotropic porous materials of a given microstructure. Under conditions of transverse isotropy, i.e. spheroidal voids in a transversely isotropic matrix, and axisymmetric loading, the numerical approach delivers quasi-exact results. Comparison of the analytical and numerical yield loci for selected material properties indicates significant improvements with respect to previous models from the literature.
A model for mining relevant and non-redundant information

Field: Computer Science (Physical Sciences)

We propose a relatively simple yet powerful model for choosing relevant and non-redundant pieces of information. The model addresses data mining or information retrieval settings where relevance is measured with respect to a set of key or query objects, either specified by the user or obtained by a data mining step. The problem addressed is not only to identify other relevant objects, but also ensure that they are not related to possible negative query objects, and that they are not redundant with respect to each other.
Anxiety Evolution among Healthcare Workers—A Prospective Study Two Years after the Onset of the COVID-19 Pandemic Including Occupational and Psychoemotional Variables

Field: Psychology (Social Sciences)

Background and objectives: Although previous research has found a high prevalence of anxiety during the COVID-19 pandemic among healthcare workers, longitudinal studies on post-pandemic anxiety and predictor variables have been less abundant. To examine the evolution of anxiety in healthcare workers from the beginning of the pandemic until one and a half years later, analyzing the influence of occupational and psychosocial variables, as well as their possible predictors. Materials and Methods: This was a prospective longitudinal design with three periods of data collection: (1) between 5 May and 21 June 2020, (2) six months after the end of the state of alarm (January–March 2021), and (3) one year after this second assessment (April–July 2022), in which generalized anxiety (GAD-7) was evaluated, as well as occupational and psycho-emotional variables (i.e., social support, self-efficacy, resilience, and cognitive fusion) in healthcare workers in direct contact with COVID-19 patients in Spain. Results: A high prevalence of anxiety was found, with a clear decrease over time. Associations were found between anxiety and certain sociodemographic and work variables (i.e., years of experience, p = 0.046; COVID-19 symptoms, p = 0.001; availability of PPE, p = 0.002; workload, p < 0.001; family contagion concern, p = 0.009). Anxiety maintained negative relationships with social support (p < 0.001), self-efficacy (p < 0.001), and resilience (p < 0.001) and positive associations with cognitive fusion (p < 0.001). Cognitive fusion seemed to be a clear predictor of anxiety. Conclusions: Our findings suggest that social support, self-efficacy, and resilience act as buffers for anxiety, whilst cognitive fusion was found to be a clear risk factor for anxiety. It is important to emphasize the risk role played by cognitive fusion on HCWs as a clear risk factor for stressful work events. The findings emphasize the need to implement specific interventions to promote the mental well-being of healthcare workers, particularly in crisis contexts such as the COVID-19 pandemic.
Damage to the cytoplasmic membrane and cell death caused by dodine (dodecylguanidine monoacetate) in Pseudomonas syringae ATCC 12271

Field: Immunology and Microbiology (Life Sciences)

Treatment of Pseudomonas syringae cells with low concentrations of the fungicide dodecylguanidine monoacetate (dodine) resulted in cell death and leakage of K+, UV-absorbing materials, and ribose-containing molecules. The results suggest that dodine causes gross and extensive damage to the cytoplasmic membrane, which is probably implicated in the death of cells.
Performing healthy ageing through images: From broadcasting to silence

Field: Social Sciences (Social Sciences)

This article addresses the centrality of images in the definition of a new paradigm for ageing, when health (measured by autonomy) becomes a condition for freedom (associated with youth). Based on a 16-month ethnography conducted with older people (aged 50–80) in a middle-class district in São Paulo, Brazil, I found that smartphones empower older people to craft a health identity by engaging and producing content that highlights the positive aspects of ageing. In this community, health is a concept deeply associated with productivity, and social media becomes a space for participants to present themselves as busy, giving visibility to all of the activities they engage with. On WhatsApp groups, participants can also work as curators, sharing content that is in the public interest, which improves their collective experience of ageing and restores their sense of utility and dignity. I found that smartphones also allow participants to manipulate the mechanism of social comparison used to classify who is healthy and who is old. Often, when they have a condition or frailty, they confine themselves to online interactions, hiding from view the ageing body that could compromise their performance. By doing that, their declines are kept on the backstage of their social interactions, allowing participants to extend their presence within the third age, which is associated with freedom and autonomy, while the decline related to the fourth age is kept in the shadows.
Identification of a complex between alpha-actinin and the intermediate filament subunit skeletin in bovine heart Purkinje fibres.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

A three-dimensional cytoskeleton, morphologically composed of intermediate filaments, desmosomes, and Z-disks, remains in bovine heart Purkinje fibres after extraction with Triton X-100 and low and high ionic strength solutions. Biochemically this cytoskeleton mainly consists of skeletin (Mr approximately 55 000) and of alpha-actinin (Mr approximately 95 000). Minor high molecular weight components are also present. By gel electrophoresis-derived enzyme-linked immunosorbent assay (GEDELISA) we show here that a 150 000-dalton component is a complex of alpha-actinin and skeletin. Furthermore, this 150 000-dalton component has now been purified and can be converted into 95 000- and 55 000-dalton subunits by reduction with a high concentration of beta-mercaptoethanol and heating. We also show that solubilized pure skeletin and pure alpha-ctinin from Purkinje fibres, after mixing, partly form a stable complex with a molecular weight of about 150 000 daltons.
Ulcerative colitis and Nephrotic syndrome: a two-sample Mendelian randomization study

Field: Medicine (Health Sciences)

Abstract

Objectives This study employed Mendelian randomization to investigate the potential causal relationship between ulcerative colitis and nephrotic syndrome Methods We obtained the whole-genome association study data of ulcerative colitis in the European population from the GWAS database. Relevant single nucleotide polymorphisms (SNPs) were selected for analysis. We employed the inverse variance-weighted meta-analysis of multiplicative random effects models to obtain SNP-specific Wald ratio estimates, which assume horizontal pleiotropy. In addition, we performed sensitivity analyses using MR-Egger, weighted median, and IVW. Results Our findings suggest a strong association between ulcerative colitis and nephrotic syndrome(P < 0.05). After conducting sensitivity analyses, we found no evidence of horizontal pleiotropy or heterogeneity(P > 0.05). Conclusion Our Mendelian randomization study provides evidence for an association between ulcerative colitis and nephrotic syndrome, which may help us better understand the conditions of ulcerative colitis and nephropathy, as well as their relationship.
Developing a System for Big Data Discovery

Field: Computer Science (Physical Sciences)

In this research, we developed a system for collecting metadata of existing Big Data in an enterprise or organization. All collected metadata are stored in metadata storage. The collected Meta Data help in managing the existing Big Data. Also, in this research, we developed a technique for discovering simple knowledge from existing Big Data (Twitter & websites) and extracted the correlation between different Big Data. Since Big Data are distributed across a large number of remote machines, we used a mobile agent technology to build our system for reducing the discovery time. The mobile agent migrate to the remote machine for discovering the required data and in consequence reduce the transportation time.Â
The Spirit, New Creation, and Christian Identity

Field: Arts and Humanities (Social Sciences)

Considering the importance of pneumatological themes for interpreting Paul’s argument of Galatians, Grant Buchanan explores how Paul draws from Jewish traditions of creation and the Spirit and presents a fresh cosmogony to the Galatian church. He suggests that Galatians outlines an epistemological shift in how Paul sees past, present, and future reality in light of Christ and the presence of the Spirit in the lives of the believers. Central to this new cosmogony is the centrality of the Spirit in Paul’s argument in Galatians 3:1–6:17, with Buchanan’s exegesis revealing that the Spirit, the Galatians’ identity as children of God and the new creation motif are not merely elements of Paul’s argument but central to it.
Sean T. Cadigan. Hope and Deception in Conception Bay: Merchant-Settler Relations in Newfoundland, 1785–1855. Buffalo, N.Y.: University of Toronto Press. 1995. Pp. xiv, 242. Cloth $45.00, paper $18.95

Field: Social Sciences (Social Sciences)

Sean T. Cadigan. Hope and Deception in Conception Bay: Merchant-Settler Relations in Newfoundland, 1785–1855. Buffalo, N.Y.: University of Toronto Press. 1995. Pp. xiv, 242. Cloth $45.00, paper $18.95 Cadigan Sean T.. Hope and Deception in Conception Bay: Merchant-Settler Relations in Newfoundland, 1785–1855. Buffalo, N.Y.: University of Toronto Press. 1995. Pp. xiv, 242. Cloth $45.00, paper $18.95. Graeme Wynn Graeme Wynn University of British Columbia Search for other works by this author on: Oxford Academic Google Scholar The American Historical Review, Volume 101, Issue 5, December 1996, Pages 1652–1653, https://doi.org/10.1086/ahr/101.5.1652-a Published: 01 December 1996
Supplementary Material from Energy conservation characterizes sleep in sharks

Field: Neuroscience (Life Sciences)

Sharks represent the earliest group of jawed vertebrates and as such, they may provide original insight for understanding the evolution of sleep in more derived animals. Unfortunately, beyond a single behavioural investigation, very little is known about sleep in these ancient predators. As such, recordings of physiological indicators of sleep in sharks have never been reported. Reduced energy expenditure arising from sustained restfulness and lowered metabolic rate during sleep have given rise to the hypothesis that sleep plays an important role for energy conservation. To determine whether this idea applies also to sharks, we compared metabolic rates of draughtsboard sharks (Cephaloscyllium isabellum) during periods ostensibly thought to be sleep, along with restful and actively swimming sharks across a 24 h period. We also investigated behaviours that often characterize sleep in other animals, including eye closure and postural recumbency, to establish relationships between physiology and behaviour. Overall, lower metabolic rate and a flat body posture reflect sleep in draughtsboard sharks, whereas eye closure is a poorer indication of sleep. Our results support the idea for the conservation of energy as a function of sleep in these basal vertebrates.
Systematically mapping gray matter abnormal patterns in drug-naïve first-episode schizophrenia from childhood to adolescence

Field: Neuroscience (Life Sciences)

Abstract Background Schizophrenia originates early in neurodevelopment, underscoring the need to elaborate on anomalies in the still maturing brain of early-onset schizophrenia (EOS). Methods Gray matter (GM) volumes were evaluated in 94 antipsychotic-naïve first-episode EOS patients and 100 typically developing (TD) controls. The anatomical profiles of changing GM deficits in EOS were detected using 2-way analyses of variance with diagnosis and age as factors, and its timing was further charted using stage-specific group comparisons. Interregional relationships of GM alterations were established using structural covariance network analyses. Results Antagonistic interaction results suggested dynamic GM abnormalities of the left fusiform gyrus, inferior occipital gyrus, and lingual gyrus in EOS. These regions comprise a dominating part of the ventral stream, a ventral occipitotemporal (vOT) network engaged in early social information processing. GM abnormalities were mainly located in the vOT regions in childhood-onset patients, whereas in the rostral prefrontal cortex (rPFC) in adolescent-onset patients. Moreover, compared with TD controls, patients’ GM synchronization with the ventral stream was disrupted in widespread high-order social perception regions including the rPFC and salience network. Conclusions The current findings reveal age-related anatomical abnormalities of the social perception system in pediatric patients with schizophrenia.
Authentication and Access Control in 5G Device-to-Device Communication

Field: Computer Science (Physical Sciences)

Device-to-device (D2D) communication is one of the most recent advancements in wireless communication technology. It was introduced in cellular communication technology by the 3rd Generation Partnership Project (3GPP) to lay a foundation for the evolving 5G architecture. It has now emerged as a promising technology for proximate devices. It enables proximate devices to communicate directly without the involvement of a third party network infrastructure. Researchers are analysing various methods to facilitate the smooth integration of D2D communication technology into the existing network system architecture. This paper lists all the different possible modes of operation in D2D communication based on the varying use-case scenarios and highlights the security and privacy requirements for D2D communication. Some of the recent authentication proposals for D2D communication technology are further reviewed, and their security and privacy capabilities are analysed. Apart from authentication, we also reviewed some recent proposals of access control in D2D and highlighted the security issues addressed. We then identified the open issues that prevail in implementing D2D technology in a real-world scenario for future researchers, emphasising the existing authentication and access control techniques in D2D communication.
Influence of carbon source on arylsulfatase derepression in Pseudomonas C12B

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Compared with growth on citrate, growth of Pseudomonas C 12 B with acetate as a carbon source resulted in approximately a four- to six-fold reduction in arylsulfatase activity irrespective of the sulfur source utilized to derepress arylsulfatase formation. Similarly, when O-acetyl-L-serine, oxaloacetate, malate, or α-ketoglutarate served as carbon sources in place of acetate, a reduction in arylsulfatase levels also occurred to varying degrees Trivial explanations for these results have been ruled out but efforts to provide an explanation for the inhibitory effect of acetate were unsuccessful. Some evidence suggests that growth on acetate may generate the formation of a substance which inactivates or irreversibly inhibits the enzyme.
Research on Security Analysis and Assessment of Quantum Secure Communication System

Field: Computer Science (Physical Sciences)

The application of quantum private communication system can improve the security protection capability of power information system. However, the application of quantum private communication system may introduce new security risks. Therefore, it is necessary to analyze and evaluate the security of quantum private communication system, relying on relevant national standards and regulations, and using traditional Security risk assessment means for risk assessment and security analysis of quantum private communication systems. This project conducts a security risk assessment for a quantum private communication system. With reference to relevant national standards, the security risk points of quantum private communication systems are studied, and the quantum private communication systems are evaluated from various aspects such as Quantum secure communication system network security, quantum key distribution equipment host security, quantum key application software security, quantum channel security. Focus on finding security risks and improve the system's own security protection capabilities. Achieve the integrity, confidentiality and usability of a quantum private communication system.