jimnoneill/paper-to-field-training huggingface dataset:
DataSheet_1_NDUFC1 Is Upregulated in Gastric Cancer and Regulates Cell Proliferation, Apoptosis, Cycle and Migration.pdf

Field: Medicine (Health Sciences)

<p>Gastric cancer is one of the most common primary tumors of the digestive system. NADH: ubiquinone oxidoreductase subunit C1 (NDUFC1), which is an accessory subunit of the NADH dehydrogenase (complex I), is responsible for the transportation of electrons from NADH to the respiratory chain essential for the oxidative phosphorylation. However, little is known about the roles of NDUFC1 in carcinogenesis. In this study, NDUFC1 protein level in NSCLC tissues was tested by immunohistochemistry (IHC) staining. NDUFC1 mRNA level in gastric cancer cell lines was determined by qRT-PCR. MGC-803 and SGC-7901 cells were transfected with shNDUFC1 lentivirus designed to silence NDUFC1. MTT assay, CCK8 assay, wound healing assay and transwell migration assay were conducted. Cell cycle and apoptosis were detected by flow cytometry. In vivo experiments were performed using nude mice. The results indicated that overexpressed NDUFC1 in gastric cancer was related to more serious tumor infiltrates, a higher risk of lymphatic metastasis, a higher proportion of positive lymph nodes, and a more advanced tumor stage. Compared with shCtrl groups, MGC-803 and SGC-7901 of shNDUFC1 groups had lower abilities of proliferation and migration, higher levels of apoptosis. NDUFC1 knockdown also inhibited SGC-7901 cell growth in vivo and suppressed Ki67 expression in xenograft tumors. More importantly, we found that NDUFC1 downregulation made the levels of P-Akt, P-mTOR, CCND1, CDK6, PIK3CA, Bcl-2, Survivin, and XIAP decreased, and that PI3K/AKT signaling pathway agonist SC79 rescued the inhibitory effects on cell proliferation and migration, reversed the promoted effects on cell apoptosis caused by NDUFC1 knockdown. More importantly, compared with NDUFC1 knockdown group, the expression of P-Akt, Bcl-2, Survivin, and XIAP was raised in shNDUFC1 + SC79 group. Thus, our suspicion was that NDUFC1 exacerbates NSCLC progression via PI3K/Akt pathway. Taken together, our study indicated that targeting NDUFC1 could open innovative perspectives for new multi-targeting approaches in the treatment of gastric cancer.</p>
‘MUSCADINE GRAPE SKIN EXTRACT INHIBITS ANDROGEN‐INDEPENDENT PROSTATE CANCER CELL GROWTH, INDUCING CELL‐CYCLE ARREST, AND DECREASING MIGRATION BY TARGETING HEAT SHOCK PROTEIN 40

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Previously we demonstrated that muscadine grape skin extract (MSKE), a natural product, significantly inhibited androgen‐responsive prostate cancer cell growth by inducing apoptosis through the targeting of survival pathways. However, the therapeutic effect of MSKE on more aggressive androgen‐independent prostate cancer remains unknown. This study examined the effects of MSKE treatment in metastatic prostate cancer using complementary PC‐3 cells and xenograft model. MSKE significantly inhibited PC‐3 human prostate cancer cell tumor growth in vitro and in vivo. The growth‐inhibitory effect of MSKE appeared to be through the induction of cell‐cycle arrest. This induction was accompanied by a reduction in the protein expression of Hsp40 and cell‐cycle regulation proteins, cyclin D1 and NF‐kBp65. In addition, MSKE induced p21 expression independent of wild‐type p53 induced protein expression. Moreover, we demonstrate that MSKE significantly inhibited cell migration in PC‐3 prostate cancer cells. Overall, these results demonstrate that MSKE inhibits prostate tumor growth and migration, and induces cell‐cycle arrest by targeting Hsp40 and proteins involved in cell‐cycle regulation and proliferation. This suggests that MSKE may also be explored either as a neo‐adjuvant or therapeutic for castration resistant prostate cancer.
A virtual predictive keyboard as a learning aid for people with neuro-motor disorders

Field: Health Professions (Health Sciences)

In India, the population with severe neuro-motor impairments (like people suffering from cerebral palsy) faces an acute problem with electronic-learning because there is a dearth of quality learning aids available for them. By quality learning aids we mean certain softwares that can help this section of special users to learn fast and at the same time with ease. Though similar systems are available in the international market, all of such products have a cost ranging from a few hundred to a few thousand dollars. For an average Indian user, they are too costly to afford. Moreover these products come in foreign languages which cannot facilitate the learning of the Indian languages. Keeping these two problems in focus, we have tried to design and develop a few learning aids which helps these section of users to learn and that too in their own languages. All these tools are indigenous and at the same time available at an affordable price. In this paper we would discuss about a predictive virtual keyboard, which not only helps these users to learn typing but also helps them to write essays, letters, and even compose poetry. All of these they can do in their own language.
A Review of the List of Plant Diseases in Korea and the Names of Korean Tree Diseases

Field: Agricultural and Biological Sciences (Life Sciences)

Since the List of Plant Diseases in Korea (DisList) was first published in 1986, the 6th edition appeared 36 years later. In 2023, the 6.1 edition, a revised and improved version of the 6th edition, was released to the public on the web free of charge. The contents of DisList increased, with the number of hosts increasing from 437 taxa to 1,420 taxa and the number of disease species increasing from 1,539 to 6,680. Among these, tree diseases are 3,586 species and their hosts include 504 taxa, providing much help to experts who need them. Meanwhile, the importance of accurate disease names continues to grow with the legalization of tree care, but many disease names are still inappropriate or misused, causing confusion. Disease names that do not follow the naming regulations are still registered, and even if the same pathogen infects hosts of the same taxa, the disease names are given differently, and there are many disease names that do not indicate the characteristics of the disease. Also, there are diseases reported without Korean names. In order to make DisList better, the review committee for disease names should establish the regulations to review and register disease names, and establish a system to review new disease names before publishing papers.
Novel Technique with Double Free Flap Design for Advanced Mandibular Osteoradionecrosis: A Case Series

Field: Medicine (Health Sciences)

Summary: Advanced mandibular osteoradionecrosis is arguably among the most challenging cases for reconstructive head and neck surgeons. Several reconstructive methods for complex mandibular defects have been reported; however, for advanced mandibular osteoradionecrosis, a safe option that minimizes the risk of renewed fistulation and infections is needed. For this purpose, we present a new technique using a fascia-sparing vertical rectus abdominis musculocutaneous flap as protection for a vascularized free fibula graft (FFG). This technique also optimizes recipient site healing and functionality while minimizing donor site morbidity. Our initial experiences from a 4 patient case series are included. Mean operative time was 551 minutes (SD: 81 minutes). All donor sites were closed primarily. Mean time to discharge was 13 days (SD: 7 days), and mean time to full mobilization was 2 days (SD: 1 days). This double free flap technique completely envelops the FFG and plate with nonirradiated muscle. It allows for the transfer of an FFG without a skin island, thus avoiding the need for split skin graft closure. This results in faster healing and minimizes the risk of fibula donor site morbidity. The skin island of the vertical rectus abdominis musculocutaneous flap has the added benefit of providing intraoral lining, which minimizes contractures and trismus. Although prospective long-term studies comparing this approach to other double flap procedures are needed, we argue that this technique is an optimal approach to safeguard the mandibular FFG reconstruction against the inherent risks of renewed complications in irradiated unhealthy tissue.
Menu Labeling as a Potential Strategy for Combating the Obesity Epidemic: A Health Impact Assessment

Field: Health Professions (Health Sciences)

Objectives. We conducted a health impact assessment to quantify the potential impact of a state menu-labeling law on population weight gain in Los Angeles County, California. Methods. We utilized published and unpublished data to model consumer response to point-of-purchase calorie postings at large chain restaurants in Los Angeles County. We conducted sensitivity analyses to account for uncertainty in consumer response and in the total annual revenue, market share, and average meal price of large chain restaurants in the county. Results. Assuming that 10% of the restaurant patrons would order reduced-calorie meals in response to calorie postings, resulting in an average reduction of 100 calories per meal, we estimated that menu labeling would avert 40.6% of the 6.75 million pound average annual weight gain in the county population aged 5 years and older. Substantially larger impacts would be realized if higher percentages of patrons ordered reduced-calorie meals or if average per-meal calorie reductions increased. Conclusions. Our findings suggest that mandated menu labeling could have a sizable salutary impact on the obesity epidemic, even with only modest changes in consumer behavior.
The Temporal and Spatial Suitability Assessment in the Tourism Resources Development of Agricultural Heritage System —Taking Congjiang County in Guizhou Province as a Case

Field: Environmental Science (Physical Sciences)

Clarify and assess the tourism resources in a scientific way is the premise of the tourism development, and in which the temporal and spatial assessment of the resources development is one of the most important issues. Rice-fish agricultural heritage system in China was listed in the GIAHS (Globally Important Agricultural Heritage System) inventory by FAO (Food and Agricultural Organization of the United Nations), and the dynamic conservation need gives the chance of tourism development in those heritage sites. The Rice-fish System could be considered as a kind of tourism resource and the value or function of it should be evaluated before tourism development in those areas, at the same time, it is also an important aspect of the tourism planning in those sites. Taking the Rice-fish system of Congjiang County as a case, this paper assesses the temporal and spatial suitability of the agricultural heritage development as tourism resources by using the quantitive method and building the index system from the temporal and spatial point. The result shows that: 1) the beginning of the summer (in June) and Autumn (from September to October) are the best seasons for the rice-fish agricultural heritage tourism development; 2) the towns such as Douli-Xishan-Yongli-Bingmei-Gaozeng-Guandong-Luoxiang-Qingyun in the northeast of Congjiang County are the best areas to make tourism development, while the towns in the southwest of the county are not in a good condition for tourism development as their poor accessibility; 3) to connect the northeast and the southwest parts of the county and integrate the tourist zone are very important for the tourism development, and it is crucial to pay attention to the transportation problem of Xiajiang town which is the joint point of the two parts. The index system built to access the temporal and spatial suitability of rice-fish system tourism development is easy to implement and clear to understand, which can provide the basis for the other studies and lay the foundation for the agricultural heritage tourism development study.
Functional anatomy reveals secretory activity in papillose anthers of a buzz‐pollinated Solanum species (Cyphomandra clade – Solanaceae)

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Pollination in Solanum (Solanaceae) species is commonly performed by female bees, which vibrate anthers to extract pollen. Another pollen removal type is by male euglossine bees, milking the anthers when searching for floral scents produced by secretory tissues (osmophorous) at the swollen connective of the anthers of species in the Cyphomandra clade. Some species of this clade, however, are buzz‐pollinated and present papillate anthers that should also have secretory activity, a hypothesis here tested. The anthers of Solanum luridifuscescens were fixed at different stages of development and analysed under light microscopy, SEM and TEM . Histochemical tests for the detection of starch and lipids were done. Epidermal cells of the abaxial surface of the anthers were visibly papillose, had large nuclei and dense cytoplasm rich in organelles such as mitochondria and plastids, typical features of secretory tissues. In this site, lipid droplets were detected, concomitantly with starch consumption, compatible with the secretory process in osmophores. No exudate or accumulation of substances was seen on the surface; in agreement with a previous pollination study performed in field conditions, where no pollinators were observed collecting floral scents, only pollen. The histochemical and structural analyses have evidenced the lipidic composition of the secretion, strongly pointing to terpenes as the secreted compounds. Ours findings show that papillae of the anthers have secretory activities that produce lipophilic compounds. This does not result in resources for bees, but could be an evolutionary step to the development of more specialised anthers in the Cyphomandra clade.
Bay of Quinte/Big Bay/Robinson Cove ostracode surface sample dataset

Field: Earth and Planetary Sciences (Physical Sciences)

Raw data for the Bay of Quinte/Big Bay/Robinson Cove ostracode surface sample dataset submitted to the Neotoma Paleoecology Database. Data is available through the landing page in JSON format. The landing page referenced by the DOI also contains links to publications and a map-based viewer for the dataset. The Neotoma Paleoecology Database maintains a homepage at https://www.neotomadb.org.
Application of the COM-B model to the correlates of children’s outdoor playing and the potential role of digital interventions: a systematic literature review

Field: Psychology (Social Sciences)

Children’s reduced engagement in outdoor playing in recent years has contributed to increasing academic and practice interests in understanding this behavior, as well as investigating the effectiveness of combined social, physical and digital interventions on stimulating children’s outdoor playing. This paper provides a systematic review of recent empirical evidence on the correlates of the outdoor playing behavior of children, ages 4–12. In addition, the potential roles of digital interventions in stimulating children’s outdoor playing are explored. The COM-B behavior change model is used to establish relevant correlates and functions of digital interventions. COM-B model defines behavior as the result of an interaction between three components: capability, opportunity and motivation. This model provides a basis for designing effective behavior change interventions. This paper’s contribution is twofold: it presents the case for adding ‘digital environment’ as a new component of the COM-B model, and it further develops a conceptual framework of different functions of digital interventions aiming at stimulating children’s outdoor playing behavior. The findings contribute to the theory-based behavior change interventions stimulating children’s outdoor playing.
Effect of reactor irradiation on the electrophysical properties of the semiconductive solid solution CdTe-HgTe

Field: Physics and Astronomy (Physical Sciences)

Specimens of Cd/sub x/Hg/sub 1-x/Te(x = .22) with n-type conductivity were irradiated in an IRTR-2000 reactor at 323 and 77/sup 0/K. Data are presented on the relative change in charge carrier concentration versus neutron dose. The data support the hypothesis that reactor irradiation induces generation and recombination of Frenkel defects and formation of In. (HDR)
Pros and cons of initial public offerings

Field: Business, Management and Accounting (Social Sciences)

The objective of this paper is to explain the pros and cons of going public as well as the factors considered by the firms in their decision making process. This study attempts to highlight the actual costs and benefits considered by the firms and their relative importance as perceived by the firms. To achieve this objective, 67 questionnaires were sent out to Singapore companies that have gone public in the last 7 years, from 1987 to 1993. The questionnaire provided a list of the costs and benefits which we feel may be important. The financial controllers of the firms, to whom the questionnaires were addressed, would then rank the relative importance of these factors.
Pennsylvania Society, state nurses association speak out on lidocaine syringe danger

Field: Nursing (Health Sciences)

Journal Article Pennsylvania Society, state nurses association speak out on lidocaine syringe danger Get access American Journal of Hospital Pharmacy, Volume 48, Issue 10, 1 October 1991, Page 2082, https://doi.org/10.1093/ajhp/48.10.2082 Published: 01 October 1991
Design and Simulation of Microwave Oscillator

Field: Engineering (Physical Sciences)

This paper is concerned with the design and simulation of fixed frequency microwaveoscillator. Scattering parameters of the active device (MESFET-Afm02n8b) are used todesign and synthesize the oscillator. The computer aided design package (MicrowaveOffice 2000 version 3.22) is employed to optimize oscillator subcircuits performancesuch as resonator, feedback, and output matching network. Two techniques areemployed for the analysis purposes. The first method involves the open-loop gain andphase response versus frequency, the second method considers the oscillator as one-portwith negative resistance. Fixed frequency oscillator at 7GHz is realized and tested.
IMPROVING DIGITALIZATION THROUGH CO-CREATION: CASE OF THE CITADEL PROJECT

Field: Social Sciences (Social Sciences)

This article examines problems related to digitalization and use of digital services provided by the government. The study is based on the research work and results of the CITADEL project, which has tested co-creation methods in Latvia considering requirements and interests of society and businesses in decision making processes of public administration. It appears that in many cases people aren’t willing to accept proposed services as they haven’t been involved in the processes of their creation. While enjoying benefits provided by information technologies, electronic services and artificial intellect people still need an exchange between human beings to make a good use of existing advanced solutions. This is especially important for electronic services widely used by a large part of the population and enterprises, which need to be easy, fast and friendly. The concept of co-creation or co-production has been initially developed in the 1970s emerging from theoretical and empirical analysis of urban service delivery. Nowadays the co-creation is becoming a priority of many governments in the world and scholars in public administration see the potential of ICTs in this exchange process. Governments around the world are promoting an increased use of ICTs to predict and understand the complexity of public services, as well as to improve the transparency and efficiency of government practices and facilitate democratic practices using e-government solutions. This paper aims at contributing to the concept of co-creation and the impact of digitalisation of public services. The article concludes that efficient decision-making for improving economic development, as well as social welfare at regional, national and local levels needs implementation of digitalised services applying new modern approaches, such as the co-creation as they inevitably become more important due to the increased digital competitiveness of countries.
Guided Evolutionary Approaches for Redesigning Water Distribution Networks

Field: Engineering (Physical Sciences)

The paper describes water distribution network optimization procedures proposed for the Battle of Background Leakage Assessment for Water Networks (BBLAWN) competition. The tested optimization methodologies build upon research carried out in the earlier Battle of the Water Networks II (BWN-II), hosted in the Water Distribution System Analysis 2012 (WDSA 2012) conference. Two approaches were evaluated: a single-objective genetic algorithm and a multi-objective genetic algorithm, both taking advantage of a guided mutation scheme. Computations have been carried out in a Java version of EPANET aiming at increased computational efficiency, greater platform portability, and improved flexibility regarding optimization software.
Practicing VOM in VR – Predictors of the Intention to Use VR

Field: Psychology (Social Sciences)

The study deals with factors predicting the Use of Virtual Reality (VR) as preparation for Victim-offender Mediation (VOM). It is useful in order to remove occurring insecurities about the process and feelings of anger and anxiety. Factors are taken from the Technology Acceptance Model (TAM) and the Theory of Planned Behaviour (TPB). Additionally, the factors knowledge and involvement with VR and personal innovativeness in the domain of technology are tested which were included in neither TAM nor TPB. It was part of the research to find out if those factors predict the intention to use VR to get acquainted with VOM, as limited knowledge about this specific topic is known so far. The factors perceived ease of use, perceived behavioural control, perceived usefulness, personal innovativeness and knowledge and involvement of the user were expected to predict the intention to use VR to get acquainted with VOM. Furthermore, an interaction effect with anxiety and anger was predicted. An online survey was conducted with students and people from the researcher's network (N=110). An imaginary crime scenario was presented to them, and they were introduced to the VR application. Afterward, they had to answer questions regarding their opinion on this technology and their intention to use the VR application and intention to participate in VOM in general. Results were in line with the expectations, perceived ease of use of the VR application, perceived usefulness of the VR application and personal innovativeness in the domain of technology are positive predictors for the intention to use VR to get acquainted with VOM. However, perceived behavioural control of the VR application and knowledge and involvement with VR were no predictors. An interaction effect between the knowledge and involvement and Anger and was found. A revision of the study by actually using VR would be useful to complement other studies and add to the further development of VOM as proper preparation is an important factor for sufficient participation in the process.