jimnoneill/paper-to-field-training huggingface dataset:
The impact of ozone on health-promoting, microbiological, and colour properties ofRubus ideausraspberries

Field: Agricultural and Biological Sciences (Life Sciences)

El presente estudio se propuso definir el impacto que la duración y la concentración de la ozonización tienen sobre determinadas propiedades químicas, físicas y microbiológicas de frambuesas rojas, Rubus ideaus, de la variedad polka. Con este objetivo, la fruta de la frambuesa fue expuesta a un chorro de ozono en concentraciones de 0,3 y 0,9 mg/L durante 60 y 120 minutos. El alcance del estudio permitió medir la acidez valorable, la concentración de sólidos solubles y los indicadores de las propiedades promotoras de la salud, que incluyen el contenido de compuestos fenólicos, flavonoides, antocianinas y vitamina C, así como el total de actividad antioxidante en los días 0, 4 y 8 de almacenamiento. La fruta sometida al tratamiento con ozono presentó niveles más elevados de compuestos fenólicos y de actividad antioxidante en comparación con los mostrados por las frambuesas no tratadas. Además, el uso de ozono ayudó a limitar el crecimiento de levadura y moho en la superficie de las frambuesas, constatándose que el tratamiento con una dosis de ozono de 0.9 mg/L durante 60 minutos fue el más eficiente.
Arendt's political philosophy - in view of critique and reception of Kant's philosophy

Field: Arts and Humanities (Social Sciences)

한나 아렌트의 정치철학에 대해 최근 새로운 철학적 접근이 이루어지고 있다. 접근방향의 다양성에도 불구하고 현대의 이론가들이 공통적으로 인정하는 바는 공영역과 정치의 복원에 대한 아렌트의 일관된 신념이다. 아렌트는 아리스토텔레스의 공/사, 실천/제작의 개념구분을 받아들여 공영역과 행위-실천의 문제에 집중하는 한편, 실천보다 사유-관조를 우위에 두었던 서양 정치철학 전통을 비판하였다. 아울러 정치의 도구성 대신 자율성을 강조함으로써 근대의 실천철학과도 거리를 두었다. 특히 아렌트는 칸트의 실천철학에 대해 정치의 영역 바깥에 존재하는 실천의 형이상학으로서 이성에 대한 의지의 종속성을 확인해줄 뿐이라고 비판하였다. 그럼에도 불구하고 아렌트는 칸트의 에서 제시된 반성적 취미판단의 이론을 수용하였고, 특히 칸트의 공통감 및 확장된 심성 개념을 통해 자신의 정치적 판단이론을 완성하였다. 한편으로는 정치라는 활동적 삶의 영역을 활성화시키려는 관심, 그리고 다른 한편으로는 이론과 실천을 연결시키고 그 이행을 매개하는 능력으로서 판단력에 대한 관심이 무엇보다 칸트의 선험적-형식적 취미판단에 대한 관심으로 이어졌고, 결국 이 관심으로부터 아렌트의 ‘정치’적 ‘판단’ 이론이 새롭게 구상된 것이다. 칸트에 대한 비판과 수용으로부터 귀결된 아렌트의 판단 및 행위이론은 무엇보다 인간의 복수성과 의사소통 가능성에 대한 새로운 정치적 의미부여라고 할 수 있다.
Treatment of Cronkhite-Canada syndrome monitored by gastrointestinal endoscopy

Field: Medicine (Health Sciences)

A man in his sixties presented at our hospital with a chief complaint of diarrhea accompanied by nail deformation, skin pigmentation, dysgeusia, anorexia, weight loss and edema of the lower leg. Laboratory data showed malnutrition, and Technetium-99m-labeled human serum albumin scan showed positive accumulation in the intestine. On endoscopy, many more polypoid lesions were found in the stomach and colon than in the esophagus, duodenum, and terminal ileum. Background mucosa between polypoid lesions was reddish and edematous. This case was diagnosed as Cronkhite-Canada syndrome, and treatment initiated with intravenous hyperalimentation, prednisolone, sulfasalazopyridine and tranexamic acid. Gastrointestinal endoscopy performed after three months of treatment showed a decrease in the number of polypoid lesions and reduction in mucosal redness and edema. Gastrointestinal endoscopy after nine months’ treatment showed a disappearance of almost all the polypoid lesions.
Sulfasalazine-induced agranulocytosis is associated with the human leukocyte antigen locus

Field: Medicine (Health Sciences)

Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to treat inflammatory joint and bowel disease. We performed a genome-wide association study comprising 9,380,034 polymorphisms and 180 HLA alleles in 36 cases of sulfasalazine-induced agranulocytosis and 5,170 population controls. Sulfasalazine-induced agranulocytosis was significantly associated with the HLA region on chromosome 6. The top hit (rs9266634) was located close to HLA-B, odds ratio (OR) 5.36 (95% confidence interval (CI) (2.97, 9.69) P = 2.55 × 10 −8). We HLA-sequenced a second cohort consisting of 40 cases and 142 treated controls, and confirmed significant associations with HLA-B*08:01, OR = 2.25 (95% CI (1.02, 4.97) P = 0.0439), in particular the HLA-B*08:01 haplotype HLA-DQB1*02:01-DRB1*03:01-B*08:01-C*07:01, OR = 3.79 (95% CI (1.63, 8.80) P = 0.0019), and with HLA-A*31:01, OR = 4.81 (95% CI (1.52, 15.26) P = 0.0077). The number needed to test for HLA-B*08:01 and HLA-A*31:01 to avoid one case was estimated to be 1,500. We suggest that intensified monitoring or alternative treatment should be considered for known carriers of HLA-B*08:01 or HLA-A*31:01.
Asymmetric Synthesis of Unnatural Amino Acid-containing Peptides <i>via</i> Direct Asymmetric Reaction of Peptidyl Compounds

Field: Chemistry (Physical Sciences)

Unnatural amino acids and the peptides bearing such units have gathered much attention due to their interesting biological activities and synthetic utility as chiral building blocks for the synthesis of complex molecules. This paper descibes an asymmetric synthesis of unnatural amino acid derivatives and their subsequent application to the preparation of unnatural amino acid-containing peptides. The α-imino carboxylic acid derivatives, which are common substrates for the synthesis of unnatural amino acids, could be readily prepared by MnO2-mediated oxidation of N-PMP-protected glycine derivatives. This reaction allowed us to synthesize novel derivatives such as α-imino perfluoroalkylesters, imides or thioesters. These compounds are useful for the synthesis of unnatural amino acid derivatives. MnO2-mediated oxidation was further applied to the synthesis of peptidyl imine. Moreover, a new methodology for the synthesis of unnatural amino acid-containing peptides was developed using the thus obtained imino peptides. This novel approach should be useful for the divergent synthesis of peptides possessing varieties of unnatural amino acid moieties.
Flexibility and efficiency enhancement for double-reheat coal-fired power plants by control optimization considering boiler heat storage

Field: Energy (Physical Sciences)

Double reheat is a potential technique to increase the efficiency of coal-fired power plants. Large penetration of renewable power requires coal-fired power plants to operate flexibly. The thermal inertia of a double-reheat boiler is extremely high due to its complicated flow, strong coupling and numerous devices, which seriously restrict the operational flexibility of double-reheat coal-fired power plants. In this study, dynamic simulation models and temperature control systems of a double-reheat boiler are developed via GSE software and then validated to understand the heat storage change law. An improved control model considering heat storage changes is proposed. The flexibility of original and improved control strategies is compared. It turns out that steam temperatures in the boiler system with the original control exceed the allowable ranges when the load cycling rate is 1.5% Pe0 min−1. By contrast, steam temperatures in the boiler system with the improved control remain within the allowable ranges when the load cycling rate is 3.0% Pe0 min−1. The response time with the improved control is shorter than that with the original control. This study is expected to provide a detailed reference for improving the flexibility of double-reheat power plants.
Risk Perception And Condom Use In Uganda

Field: Social Sciences (Social Sciences)

The paper examines the risk perception and condom use in Uganda, based on 600 respondents drawn from Kabale, Kampala and Lira districts. The majority of the respondents were aged 35 and above, were married and engaged in subsistence farming. HIV risk perception was found to be associated with condom use, religion, educational attainment, marital status, residence, number of sexual partners and having contracted an STD. Predictors of high HIV risk perception were non use of condoms, rural residence, having ever engaged in sex for gain and ever discussed sex. Mistrust of partners, past social history, having many sexual partners, and having undergone blood transfusion are the main reasons why people consider themselves at risk of contracting HIV. Ever use of condoms was at 46% among males and 27% among females. Respondents who do not consider themselves at risk of contracting HIV and those who have never contracted STDs are less likely to use condoms. Respondents who had ever engaged in gainful sex were more likely to use condoms than those who engage in sex for pleasure. Post-primary education and urban residence are strong contributors to condom use.
Phosphorylation of AMPKα at Ser485/491 Is Dependent on Muscle Contraction and Not Muscle-Specific IGF-I Overexpression

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Glucose is an important fuel for highly active skeletal muscles. Increased adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratios during repetitive contractions trigger AMP-activated protein kinase (AMPK), indicated by phosphorylation of AMPKαThr172, which promotes glucose uptake to support heightened energy needs, but it also suppresses anabolic processes. Inhibition of AMPK can occur by protein kinase B (AKT)-mediated phosphorylation of AMPKαSer485/491, releasing its brake on growth. The influence of insulin-like growth factor I (IGF-I) on glucose uptake and its interplay with AMPK activation is not well understood. Thus, the goal of this study was to determine if increased muscle IGF-I altered AMPKα phosphorylation and activity during muscle contraction. Adult male mice harboring the rat Igf1a cDNA regulated by the fast myosin light chain promoter (mIgf1+/+) and wildtype littermates (WT) were used in the study. mIgf1+/+ mice had enhanced glucose tolerance and insulin-stimulated glucose uptake, but similar exercise capacity. Fatiguing stimulations of extensor digitorum longus (EDL) muscles resulted in upregulated AMPKα phosphorylation at both Thr172 and Ser485/491 in WT and mIgf1+/+ muscles. No differences in the phosphorylation response of the downstream AMPK target TBC1D1 were observed, but phosphorylation of raptor was significantly higher only in WT muscles. Further, total raptor content was elevated in mIgf1+/+ muscles. The results show that high muscle IGF-I can enhance glucose uptake under resting conditions; however, in contracting muscle, it is not sufficient to inhibit AMPK activity.
Faculty Opinions recommendation of Control of Drosophila endocycles by E2F and CRL4(CDT2).

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Endocycles are variant cell cycles comprised of DNA synthesis (S)- and gap (G)-phases but lacking mitosis. Such cycles facilitate post-mitotic growth in many invertebrate and plant cells, and are so ubiquitous that they may account for up to half the world's biomass. DNA replication in endocycling Drosophila cells is triggered by cyclin E/cyclin dependent kinase 2 (CYCE/CDK2), but this kinase must be inactivated during each G-phase to allow the assembly of pre-Replication Complexes (preRCs) for the next S-phase. How CYCE/CDK2 is periodically silenced to allow re-replication has not been established. Here, using genetic tests in parallel with computational modelling, we show that the endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1 (ref. 7). We propose that it is the transient loss of E2F1 during S phases that creates the window of low Cdk activity required for preRC formation. In support of this model overexpressed E2F1 accelerated endocycling, whereas a stabilized variant of E2F1 blocked endocycling by deregulating target genes, including CycE, as well as Cdk1 and mitotic cyclins. Moreover, we find that altering cell growth by changing nutrition or target of rapamycin (TOR) signalling impacts E2F1 translation, thereby making endocycle progression growth-dependent. Many of the regulatory interactions essential to this novel cell cycle oscillator are conserved in animals and plants, indicating that elements of this mechanism act in most growth-dependent cell cycles. PMID: 22037307 Funding information This work was supported by: NIGMS NIH HHS, United States Grant ID: P50 GM066050 NIGMS NIH HHS, United States Grant ID: R01 GM051186 NIGMS NIH HHS, United States Grant ID: GM51186 CIHR, Canada Grant ID: MOP-86622 NIGMS NIH HHS, United States Grant ID: R01 GM057859 NIGMS NIH HHS, United States Grant ID: R01 GM051186-14A1 NIGMS NIH HHS, United States Grant ID: 5 P50GM66050 NHGRI NIH HHS, United States Grant ID: R25 HG007153 NIGMS NIH HHS, United States Grant ID: GM57859 More Less keyboard_arrow_down
Hospital Emergency Cases of Poisonings and Other Injuries Caused by Ingestion

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

MODERN TECHNOLOGY and human de- sire are creating a host of products made of new materials or designs, and an innumerable va- riety of drugs and other substances are being pro- duced and marketed every year.Many such products, particularly drugs and common household items, are subject to voluntary or accidental abuse among certain age groups in all classes of our society.To help control potentially hazardous products and protect consumers from unreasona-
Migration to Cloud Computing: A Decision Process Model

Field: Decision Sciences (Social Sciences)

This paper proposes a model that provides a structure to aid the decision making process for the migration of organisations’ IT resources to cloud-based services. It includes consideration of business intelligence as well as design phases which have been neglected by existing decision support systems. Six main steps and the tasks within the model are identified, and their interaction with a proposed knowledge base is discussed. These provide a structure that systematically guides decision makers through the cloud migration process. Finally further research is discussed, including the development of a knowledge-based decision support system which will be undertaken by the authors.
Role of Biotechnology in Drug Delivery to the Nervous System

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The delivery of drugs to the brain is a challenge in the treatment of CNS disorders (Jain 2010). The major obstruction to CNS drug delivery is the blood–brain barrier (BBB), which limits the access of drugs to the brain substance. In the past, treatment of CNS disease was done mostly with systemically administered drugs. This trend continues. Most CNS-disorder research is directed toward the discovery of drugs and formulations for controlled release; little attention has been paid to the method of delivery of these drugs to the brain. Now biotechnology is making a significant contribution to drug delivery in disorders of the CNS.
The Holy Roman Empire: women and politics beyond liberalism, individual rights, and revolutionary theory

Field: Arts and Humanities (Social Sciences)

The vast majority of studies exploring aspects of gender and power in early modern Europe have focused on England, France, and Italy, with developments in Germany – in the Holy Roman Empire – investigated only rarely. There are several reasons for this. Some of these come from its politics: the Empire, that loose amalgam of secular and religious states stretching across central Europe, does not fit into the way early modern political history is often taught – it is neither absolutist nor constitutionalist – so it is easier simply to leave it out. Its political history is, in comparison with England in the seventeenth century and France in the eighteenth, rather boring, seemingly backward, and tediously complex.
Indomethacin Spray Preparation for the Control of Pain Associated with Stomatitis Caused by Chemotherapy and Radiotherapy in Cancer Patients

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Severe stomatitis caused by chemotherapy and radiotherapy is accompanied by severe pain and results in a poor quality of life. We used a spray preparation of indomethacin (IM; 0.25% IM dissolved in phosphate buffer, pH 7.4), a nonsteroidal anti-inflammatory drug (NSAID) to control the pain associated with stomatitis at the University of Tsukuba Hospital. This review specifically aimed to collect information on the use of the IM spray preparation, from our previous studies, to facilitate its proper use in a hospital setting. On studying the stability of the IM spray preparation, we concluded that the preparation should be kept in the refrigerator for daily use, and that it can be stored for at least 2 months at 4°C, and for 24 months at -20°C. To evaluate the efficacy of the IM spray preparation, we retrospectively surveyed its analgesic effects. Using the 10-grade Visual Analogue Scale in 23 patients, we found that pain associated with stomatitis was reduced from 10 to 4.7 after application of the spray. In conclusion, our study results on the stability and efficacy of the IM spray preparation have led to the proper use of the spray in cancer patients with stomatitis caused by chemotherapy and radiotherapy.
Influence of Sugars on Oviposition of Narcissus Bulb Fly

Field: Agricultural and Biological Sciences (Life Sciences)

The normal food of narcissus bulb fly (Lampetia equestris (F.)) adults is commonly believed to be nectar or pollen. Adults have been observed visiting the flowers of plants, such as dandelion and wild buttercup, that are prevalent during the time they are most abundant. Studies were made to determine whether the nectar or the pollen was the objective of these visits. The authors observed that the flies were feeding on the nectar rather than on the pollen. To determine the influence of the food on oviposit ion, cage tests were conducted under greenhouse conditions. Adults were reared in the greenhouse slightly in advance of the season of normal occurrence outdoors.
A DEA–Tobit Analysis to Understand the Role of Experience and Task Factors in the Efficiency of Software Engineers

Field: Decision Sciences (Social Sciences)

This study employs the data-envelopment analysis (DEA)-Tobit regression approach to analyze data from a leading software engineering organization to gain insights regarding the role of various types of technical experience and task factors in the efficiency of personnel assigned to software tasks. “Efficiency” follows a holistic-view definition as the quality and productivity achieved from the overall personnel experience, and it is evaluated with DEA. Then, a Tobit regression model is employed to determine the effect that various types of technical experience and task factors have on the DEA efficiency scores. Although the DEA-Tobit technique has been applied to various areas within the management science and operations research fields, it has not yet been presented as a general evaluation tool within the software-engineering field to understand drivers of software quality and productivity. We demonstrate how DEA-Tobit fills a gap not addressed by commonly applied methods in the literature.
Stenotrophomonas maltophilia as a rare cause of meningitis and ventriculoperitoneal shunt infection

Field: Medicine (Health Sciences)

Stenotrophomonas maltophilia is an extremely rare pathogen responsible for ventriculoperitoneal shunt infection and meningitis. This young female patient with history of multiple shunt revisions in the past, came to us with shunt dysfunction and exposure of the ventriculoperitoneal shunt tube in the neck. The abdominal end of the shunt tube was seen migrating into the bowel during shunt revision. The cerebrospinal fluid analysis showed evidence of Stenotrophomonas maltophilia growth. This is the first reported case of Stenotrophomonas maltophilia meningitis associated with ventriculoperitoneal shunt migration into the bowel.
Homography Superposition of the Television Image for Multicam Machine Vision by Data of the Environmental Test

Field: Computer Science (Physical Sciences)

The homography superposition of television images is an important issue for multicam machine vision. The feature of this issue is parameters estimation by data of the environmental test. The trouble of data processing of the environmental test is point matching. The full-scan method defines the huge amount of matching. The processing time does not meet the requirements of video surveillance. Two developed procedures reduce the amount of matching. The homography superposition algorithm is developed by these procedures. It allows estimating the parameters by the acceptable for multicam machine vision time.
Learning and educating with ecological ink: a tutorial teaching practice in the Serra do Espinhaço

Field: Environmental Science (Physical Sciences)

The present work is an extension project developed by the Tutorial Education Program (PET) - Strategies to reduce the retention and dropout of academics at UFVJM. This project aimed to develop and teach the lay population in the Diamantina region to produce ecological, inexpensive and efficient paints, from the sieved soil under dilution with water and PVA - Polyvinyl Acetate glue, in order to use them to paint facades of houses and buildings of poor families or communities present in the locality. Therefore, for the performance of the project, volunteer students were selected who had an academic performance coefficient (CRA) of less than 60 or with one or more failures in subjects, in order to meet the purposes of this PET group, combating retention and evasion. During the project, the volunteer team was monitored for the performance of CRA, trained in the production of paints and in the promotion of workshops in educational institutions, which brought up issues inherent to environmental education and the production and viability of ecological paints. The project contributed to the exchange of experiences and bonds between the external and academic community, through technical visits and offered workshops.
Developing a Short Form of the Self-Assessment Practices Scale: Psychometric Evidence

Field: Psychology (Social Sciences)

This research aimed to develop a short form of the Self-assessment Practices Scale (SaPS). Guided by a process model of self-assessment, the SaPS scale was designed to assess the actions students engage in during the self-assessment process. The data used for developing the original 20-item SaPS (SaPS-20), i.e., 1,416 Hong Kong students ranging from Primary 4 to Secondary 3, were reanalyzed, and a 12-item short form (SaPS-SF) was developed. Factor analysis and Rasch analysis were applied in complementary ways to examine the psychometric properties of the SaPS-SF. The results showed that factor structure of the original scale held in the SaPS-SF, and all items fitted the Rasch model requirements sufficiently and measured the constructs as theorized. The findings presented in this study facilitate the measurement of self-assessment practice in a parsimonious and effective way.