jimnoneill/paper-to-field-training huggingface dataset:
Abstract 3648: Proteomic profiling of vorinostat in breast cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract The lysine deacetylase (KDAC) inhibitor, vorinostat or suberoylanilide hydroxamic acid (SAHA), is currently being used for treatment of cutaneous T cell lymphoma, however, its anti-breast cancer effects are under evaluation. SAHA's pluripotent effect on histone and non-histone lysine acetylation across cancer types raises the theoretical concern that it could both re-express epigenetically silenced tumor suppressors and activate oncogenic pathways as well. In order to investigate the potential role of SAHA in tumor suppressor, cell death and signaling pathways, we used quantitative mass spectrometric analysis of MCF10A normal mammary epithelial cells and MDA-MB-231 breast cancer cells treated with SAHA for 12 and 24 hours. We observed downregulation of EGFR, Ephrin type A receptors and cell cycle proteins including CDC2 and CDC42 protein kinase, which is consistent with anti-tumor activity. We found that SAHA treatment also promoted activation of proteins including Ephrin type B receptors, STAT3 and p120 Catenin. Such molecular effects must be characterized in greater detail in order to determine the potential efficacy of this drug in breast cancer. Our findings show that SAHA-mediated inhibition of KDACs results in a wide range of downstream consequences in mammary epithelial and breast cancer cells. Candidate molecules identified in this study can be used as biomarkers to assay the breast cancer response to SAHA. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3648.
Poems syndrome: report of a rare disease with often neurologic presentation

Field: Medicine (Health Sciences)

Introduction: Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome is a rare monoclonal lambda plasma cell disorder, with multisystem presentation leading to a challenging diagnosis. The aim is to report a case of a rare hematologic disease, with neurologic manifestation widely seen in daily practice. Case report: Male, 35-year-old, with a history of distal weakness of the lower limbs, symmetrical, subacute onset and progressive worsening, associated with ascending numbness, lower back pain and fatigue. Neurological examination showed motor deficit in extremities (plantar flexion and extension), hypoactive reflexes of lower limbs, in addition to distal sensory deficit (tactile and painful). Electroneuromyography confirmed axonal sensory-motor neuropathy in both lower limbs. Biochemical testing revealed a monoclonal gammaglobulin peak with a predominance of lambda chains and an elevated serum vascular endothelial growth factor (VEGF) concentration. Magnetic resonance imaging detected sclerotic lesions in vertebral bodies of thoracic and lumbar spine. Furthermore, patient also had mild pigmentary changes in the skin of the extremities of lower limbs and polycythemia. Accordingly with the evaluation was possible to make POEMS diagnosis and patient is currently in preparation for an autologous bone marrow transplant. Conclusion: Polineuropathy is a neurological hallmark of the disease and should lead to evaluation for POEMS, when associated with a monoclonal protein detected. Elevated serum VEGF can be a biomarker that supports the diagnosis. In summary, early recognition is essential, because enables adequate treatment, which contributes to stop progressive worsening of symptoms, especially debilitating neurologic ones.
History Teaching In A Museological Space

Field: Arts and Humanities (Social Sciences)

This paper aims to discuss issues concerning the teaching of History in museological spaces, based on the narrative of an experience at the Rio Grande do Sul Memorial, a place that generated the teaching-learning process of students who visited this space. We start from the narrative of the mediated educational action on the itinerant exhibition “Monuments and art: the history of the city at risk”, which exposed a series of monuments and public statues taken from the streets of Porto Alegre. By means of these pieces, the mediation sought to reflect on the silenced stories behind those sculptures, aiming to perceive other actors and groups silenced by the patrimonialization process. From a theoretical point of view, it drew on Vygotsky (2010) and Bakhtin (1992), with regard to interactive mediation; Siman (2013), with regard to teaching History through reading the city; and Ramos (2016), on the concept of generator object. Finally, it is believed that the students took possession of plural historical narratives about the city, through the narratives exposed and silenced by the urban historical heritage.
Post-buckling Analysis in Thin-web Laminated Composite Beams

Field: Engineering (Physical Sciences)

Aeronautic industry is aiming to increase the efficiency and to reduce the costs of their aircrafts, in order to develop airplanes with better performance and lower fuel consumption.Researches have demonstrated that shear panels can carry a significant amount of load after reaching its initial buckling load.Consequently, exploring the post-buckling capacity of composite materials reinforced panels results in lighter and less expensive structures.For the metallic reinforced panels there is a consolidated methodology developed by NASA to calculate the diagonal tension, NACA TN2661.However, a theory for the panel's post-buckling behaviour in composite reinforced panels is yet to be developed.Therefore, the purpose of this study was to contribute to this new theory and focus on the influence of stacking sequence and fibre orientations on the postbuckling behaviour of composite reinforced panels.The main goals were to develop a method to build a FE model to represents the post-buckling behaviour of the composite reinforced panel in order to avoid having to use experimental results in future projects; study the variations in stacking sequence in post-buckling analysis; choose the material to build a reinforced panel that have the best behaviour during the post-buckling analysis: metal or composite.The results have shown that the FEM, considering the load, boundary conditions and materials described in this study, can represent the behaviour of the composite reinforced panel and its post-buckling behaviour.Also, after the comparison between six composite reinforced panels models with different stacking sequence, the layup that presented the lowest values for the failure indices was the one with +45 and -45 at the outside layers.This laminate was chosen to be compared with the metallic reinforced panel model, and this comparison has shown that the composite reinforced panel could withstand higher loads, so it is considered the best for the post-buckling behaviour analysis.
Social profile of children and teens with cerebral palsy in a physical rehabilitation center

Field: Health Professions (Health Sciences)

Para o desenvolvimento de programas de reabilitação e ações de saúde, é preciso compreender as mudanças na vida dessas pessoas, para a execução e participação das várias atividades na vida diária. A paralisia cerebral (PC) é causa mais comum de deficiência física grave na infância. Afeta cerca de dois a cada 1.000 nascidos vivos em todo o mundo, enquanto nos países em desenvolvimento, está estimada em 7 por 1.000 nascidos vivos. Objetivo: Conhecer os universos socioeconômico e demográfico da criança com paralisia cerebral do município de São Paulo/SP. Métodos: Trata-se de estudo quantitativo, qualitativo e descritivo, em pacientes com diagnóstico clínico e funcional de paralisia cerebral, ativos em programa de reabilitação, durante o ano de 2014, residentes na cidade de São Paulo/SP, com idades entre 0 e 18 anos, de ambos os sexos. Resultados: Vinte e cinco pacientes participaram do estudo. A pesquisa revelou que 52% (13) dos pacientes são do sexo feminino, com idades de 6 a 15 anos. No âmbito econômico, 80% (20) dos pacientes possuem o Benefício de Prestação Continuada (B.P.C), sendo esta a principal fonte de renda para 40% (10) das famílias. No âmbito familiar, 88% (22) dos pacientes vivem em família nuclear, composta por casais. A segunda maior proporção 20% (5) foi de famílias monoparentais, chefiadas por mulheres. No que refere à participação da figura paterna no tratamento, 56% (14) dos casos contam com o envolvimento paterno, dos quais 91% (22) convivem com a renda familiar de até 2 S.M. Dos contextos familiares, em que não há o envolvimento paterno no tratamento, totalizam 44% (11). A maioria destas famílias vivem com renda familiar de até 1 SM 57% (14) e, em arranjos familiares distintos. Os resultados da pesquisa apontam que 1, em cada 4 pacientes não frequenta o ambiente escolar. Com relação à moradia dos pacientes, 72% (18) não possuem casa própria e, 80% (20) não possuem acessibilidade na residência. Conclusões: Conhecer o meio em que vivem as pessoas com deficiência é de extrema relevância, visto que este pode influenciar positiva ou negativamente, a vivência da saúde e doença. O dinamismo familiar e o empenho do trabalho em equipe no processo de reabilitação poderão contribuir, favoravelmente, ao bem-estar de todos e inclusão social, da criança com PC, e auxiliar na formulação das políticas públicas
Assessing Soil Degradation in Agricultural Landscapes of Semi‐Arid Tropics Using Proximal and Remote Sensing‐Based Diffuse Reflectance Spectroscopy

Field: Environmental Science (Physical Sciences)

ABSTRACT Monitoring soil degradation using the soil degradation index (SDI) is a complex process. Typically, multiple soil parameters are measured under laboratory conditions to create such a composite parameter. Because conventional soil testing methods are tedious and time‐consuming, frequent monitoring of soil degradation through SDI continues to be a challenging task. With diffuse reflectance spectroscopy (DRS) emerging as a rapid soil testing method, the major objective of this study is to examine the DRS approach for estimating SDIs in a degradation‐prone dryland landscape of Maharashtra, India. Accordingly, surface soil samples were collected from 141 locations and 20 different soil parameters were measured in these samples. Six key parameters were identified to formulate the SDI following a minimum dataset (MDS) approach: soil organic carbon content (SOC), soil erodibility index (eMCR), available S, available Mn, the ratio between exchangeable Ca to Mg and silt content. Spectral reflectance data collected under laboratory conditions and those extracted from multispectral imaging data from Sentinel‐2 L2A over the visible to infrared (VNIR) region were used to estimate SDIs and its six indicators by calibrating two popular chemometric models: support vector regression (SVR) and feature selection‐based partial‐least‐squares regression (PLSR FS ). Results showed that the SDI values could be estimated from the laboratory‐measured DRS data with the coefficient of determination ( R 2 ) value of 0.81 and root‐mean‐squared error (RMSE) value of 0.03. Similarly, chemometric models also performed well for the MSI data ( R 2 = 0.52; RMSE = 0.04). Although the laboratory‐based DRS approach provided greater estimation accuracy, low RMSE values associated with the MSI data showed that SDI may be effectively mapped for the entire study area at high spatial resolution (~10 m for Sentinel‐2 L2A data). Correlation analyses between mapped SDI and crop yield further showed yield declines with increasing soil degradation for different rainfed crops, while no such trends were observed for the irrigated crops, suggesting that irrigation management in dryland areas may circumvent land degradation challenges.
Magnetic resonance imaging of female pelvic floor dysfunction

Field: Medicine (Health Sciences)

Poster: ECR 2020 / C-14331 / Magnetic resonance imaging of female pelvic floor dysfunction by: S. Amante 1, R. Sousa1, R. Cordeiro2, M. Chaves1, A. Mesquita1, R. Amaral1, D. Garrido1, R. M. A. Cruz1; 1Ponta Delgada/PT, 2Sao Miguel - Acores/PT
An Automated Reasoning System

Field: Computer Science (Physical Sciences)

This paper is an introduction to an automated reasoning program developed at Northern Illinois University and Argonne National Laboratory over the past nine years. Recently the program has reached the stage where it can be considered a useful research tool in a variety of disciplines. It has solved open problems in mathematics and participated in the design of new electronic circuits. Here we describe the general types of capabilities provided to the user by the program and give examples of how they are currently being used in diverse areas of investigation.
Quarantine and the Exchange of Crop Genetic Resources

Field: Agricultural and Biological Sciences (Life Sciences)

Journal Article Quarantine and the Exchange of Crop Genetic Resources: Finding the balance between protecting crops and promoting global agricultural research Get access Donald L. Plucknett, Donald L. Plucknett Search for other works by this author on: Oxford Academic Google Scholar Nigel J. H. Smith Nigel J. H. Smith Search for other works by this author on: Oxford Academic Google Scholar BioScience, Volume 39, Issue 1, January 1989, Pages 16–23, https://doi.org/10.2307/1310803 Published: 01 January 1989
Prevalence of Listeria species in raw milk, ice cream and yogurt and effect of selected natural herbal extract on its survival.

Field: Agricultural and Biological Sciences (Life Sciences)

Objective: This study aimed to detect the prevalence of Listeria species in raw milk, ice cream and yogurt, and to evaluate the effect of extract of clove, thyme and pomegranate peel on such organism. Design: Descriptive study. Procedures: One hundred and fifty samples of milk, ice cream and yogurt were examined for isolation, identification and molecular identification of Listeria spp. Extraction of natural plant extract as clove, thyme and pomegranate peels and detection of their inhibitory effect on Listeria spp < strong>. Results: The prevalence of Listeria spp. in milk was 36% where 14% as L. monocytogenes, 6% L. innocua and 16% and other Listeria spp. was 16%. In yogurt, Listeria spp. was 6% as L. innocua was 2%and other Listeria spp. was 4%, while no L. monocytogenes was detected. In ice cream, Listeria spp. was 8% where L. monocytogenes was 2% and other Listeria spp. was 6% while no L. innocua was detected. The concentration of plant extract was 2.5% which showed high reduction rate on L. innocua and L. monocytogenes during shelf life of soft cheese. Conclusion and clinical relevance: Listeria is widely isolated from milk than from ice cream and yogurt. Plant extracts play role in food preservation and consider as a natural antimicrobial agent where most effective one was clove extract.
Reduction Kinetics of a Flavin Oxidoreductase LuxG from Photobacterium leiognathi (TH1): Half-Sites Reactivity

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Bacterial bioluminescence is a phenomenon resulting from the reaction of a two-component FMN-dependent aldehyde monooxygenase system, which comprises a bacterial luciferase and a flavin reductase. Bacterial luciferase (LuxAB) is one of the most extensively investigated two-component monooxygenases, while its reductase partner, the flavin reductase (LuxG) from the same operon, has only been recently expressed in a functional form. This work reports transient kinetics identification of intermediates in the LuxG reaction using stopped-flow spectrophotometry. The results indicate that the overall reaction follows a sequential-ordered mechanism in which NADH binds first to the enzyme, followed by FMN, resulting in the formation of charge-transfer intermediate 1 (CT-1) typical of those between reduced pyridine nucleotides and oxidized flavins. The next step is the reduction of FMN as indicated by a large decrease in absorbance at 450 nm. The reduction of FMN is biphasic. The first phase of FMN reduction occurs concurrently with formation of charge-transfer intermediate 2 (CT-2), while the second phase is synchronous with the decay of CT-2. When the isotope-labeled substrate, 4(R)-[(2)H]NADH, was used, the first reduction phase showed a primary kinetic isotope effect ((D)k(red)) of ≥3.9 and resulted in greater accumulation of CT-1. These results are consistent with CT-1 being the FMN(ox):NADH complex, while CT-2 is the FMN(red):NAD(+) complex. Because CT-2 decays with a rate constant of 2.8 ± 0.2 s(-1), while the turnover number obtained from the steady-steady-state kinetics is 1.7 s(-1), it is likely that the CT-2 decay step largely controls the overall reaction rate. All kinetic data are consistent with a half-sites reactivity model in which flavin reduction occurs at only one subunit at a time. The first reduction phase is due to the reduction of FMN in the first subunit, while the second phase is due to the reduction of FMN in the second subunit. The latter phase is limited by the rate of decay of CT-2 in the first subunit. The half-sites reactivity model is also supported by detection of burst kinetics during the pre-steady-state period that is correlated with 0.5 mol of the FMN being reduced/mol of the LuxG:NADH complex. The functional importance of this half-site reactivity phenomenon is still unclear.
Organizing for Outsourcing: The Case of Purchasing & Supply Management

Field: Business, Management and Accounting (Social Sciences)

Outsourcing remains one of the most prevalent business practices. Still, many businesses fail to realize the benefits anticipated from their outsourcing initiative. Research reports that one major reason for these outsourcing challenges are in the design of the focal organization. In this paper, we take an organization design view to outsourcing and elaborate on the organizational design implications for outsourcing. We present a multi-year case study from 2010 to 2013 of a global chemical and pharmaceutical company (GCC), which went through an organization redesign and subsequently successfully outsourced some organizational tasks. Specifically, we take the case of the Purchasing & Supply Management (PSM) function to illustrate how an activity-based organization design can facilitate outsourcing of some parts of the PSM function.
Competent Illiterates or Competent Literates: A Comparative Study of South Australian and South African Basic Education in Literacy and Numeracy Proficiency (Competent Literates)

Field: Social Sciences (Social Sciences)

This paper examines the influence of teachers' learning styles on their classroom teaching and learning practices.The reported mixed method study was conducted in various school districts in a large province in South Africa.The data was collected with the use of questionnaires administered to primary school natural science teachers and classroom observations made during a science lesson.The study examined the preferred learning styles of primary school science teachers.It then investigated how they taught natural science and attempted to establish if their learning styles influenced teaching and learning in their classrooms.Findings from the questionnaires showed that most teachers preferred or learned better partly through visual, active, sequential and intuitive learning styles.However, analyses of classroom observations revealed a contradiction as the teachers' proclaimed learning styles were not emulated, translated into or visible in their classroom teaching practices.The researcher argues and concludes that the teachers' learning styles do not necessary shape or influence their classroom teaching practices.
Synthesis, characterization and photocatalystic activity of multiwalled carbon nanotubes/titanium dioxide nanocomposite

Field: Materials Science (Physical Sciences)

As a result of large band gap and high recombination of photo-generated electronsholes within nanoseconds, which limit the effectiveness of anatase-phase titanium \n dioxide (TiO2) semiconductor nanoparticle. Active MWCNTs/TiO2 nanocomposites were fabricated by dispersing TiO2 onto the surface of functionalized multiwalled \n carbon nanotubes (fMWCNTs) and used it as a hotocatalyst. The optical, structural,and morphological properties of the as-prepared MWCNTs/TiO2 nanocomposites were studied. The typical particle sizes between 30 and 36 nm were achieved by TEM. This was supported by the crystal sizes of 16, 14 and 13 nm for MWCNTs/TiO2 ratios of (1:3), (1:2), and (1:1) respectively, evaluated from Shearer \n equation of the XRD spectra, which show the present of anatase and rutile states. The optical properties were characterized using UV-Vis reflection spectroscopy and \n found the band gap of 2.93, 2.86, and 2.75eV for MWCNTs/TiO2 ratios of (1:1),(1:2), and (1:3) respectively, calculated from Kubelka-Munk function. The PL peak intensity of TiO2 was higher for MWCNTs/TiO2 (1:3) as loading of TiO2 increased. The effect of the initial concentration of the methylene blue dye and pH of the medium were investigated on photocatalytic activity of the MWCNTs/TiO2 nanocomposites of the lowest band gap at the optimum mass ratio (1:3). It was found that the photodegradation followed the first order kinetics. The photocatalytic activity was found to increase with increase in the initial dye concentration after which it falls as the concentration of methylene blue is increased above optimum. At 30 min, 92.56 and 75.95% degradation efficiency were recorded for 10.2 and 7.0 pH solutions respectively. While in 1.9 pH solution, approximately 45.23% methylene blue degradation was recorded.
Exhibits and Ancillary Agreements

Field: Business, Management and Accounting (Social Sciences)

This chapter highlights the importance of exhibits and ancillary agreements that are part of a business process outsourcing (BPO) contract. It is in the exhibits to the BPO contract that the particular services to be provided are described, assets, methodologies, and technology are identified, service levels are specified, base and incremental pricing is set out, and the scope and implementation of the transition and/or transformation are detailed. The types, number, and scope of the exhibits to be attached to the BPO contract generally vary depending on the scope, location, and value of the services to be outsourced and the time frame in which the contract is to be negotiated. Often in a BPO transaction, a number of ancillary agreements are entered into as part of or in conjunction with the main services contract. The particular types of ancillary agreements entered into in connection with the overall BPO transaction are driven by the business deal at hand and, therefore, vary from transaction to transaction.
Gene therapy for arthritis 1996 - 1999

Field: Medicine (Health Sciences)

Gene therapy for rheumatoid arthritis (RA) is a relatively novel therapeutic concept. At present, two clinical trials are ongoing which evaluate the safety of ex vivo gene transfer into synoviocytes. However, it is anticipated that the number of clinical trials evaluating anti-inflammatory gene transfer strategies will increase significantly within the near future. This review summarises the pertinent patent situation for arthritis gene therapy from 1996 to 1999. A patent search with the keywords arthritis and gene therapy revealed 65 patent filings during this time period. In this report, we describe and discuss a selection of patent applications filed for novel therapeutic strategies, enabling gene delivery, and expression systems into relevant cell populations (e.g., synoviocytes, chondrocytes and mesenchymal stem cells). For the future, we envision that gene discovery efforts in connection with functional genomics will provide a wealth of novel patentable information hopefully leading to innovative gene therapy approaches for rheumatic diseases.