jimnoneill/paper-to-field-training huggingface dataset:
Mining scientific advice reports on cell-based products; insight in the non-clinical development program.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Aims The field of cell-based therapies for human diseases is currently evolving from promising treatment options to established therapeutic concepts. The design of the non-clinical development program for cell-based products, intended to provide a rationale for treatment and to gain insight into the safety profile, is challenging because of limitations caused by species-specificity. The elements of the non-clinical package for cell-based products were evaluated using advice reports from the European Medicines Agency database from 2013-2018 to identify the approach followed for non-clinical development of these products. Methods The purpose of the in vivo studies was designated to be (a combination of) pharmacology/proof-of-concept, safety, biodistribution and/or tumourigenicity. For biodistribution and tumourigenicity also the need for, type and design of in vitro and in vivo studies were recorded. Results In vivo studies for cell-based therapies were primarily aimed at proof-of-concept (75/86), followed by addressing safety (64/86), biodistribution (49/86) or tumourigenicity (46/86). No animal studies were performed or proposed by sponsors or regulators for six (out of 86) products, which contained cell types that have been studied in humans for a relatively long time. For one-third of the products in vivo biodistribution and/or tumourigenicity studies were not considered necessary. In vivo tumourigenicity studies were regarded of limited value. Conclusions Compared to more conventional medicinal products, the non-clinical development program for cell-based products was more tailored and focussing on proof-of-concept. For tumourigenicity an in vitro approach may suffice. Total omission of in vivo studies appears to be possible for products with sufficient clinical experience.
HIGH-RESISTIVE n- AND p- TYPE Ino.53G%.47As LAYERS PRODUCED BY COLD Fe-ION BOMBARDMENTS

Field: Materials Science (Physical Sciences)

We have investigated the effects of Fe-ion bombardment at 77K temperature in the electrical isolation of n- and p- type InGaAs layers. Maximum resistivity of -4x lo6 and -7x I O6 Wsq at optimum annealing temperature of -250 and 600°C has been recorded for p- and n- type InGaAs materials, respectively. Also, low dissipation loss comparable to S.I. InP substrate has been observed. Thermally stabje high resistive regions close to intrinsic value of InGaAs (- io7 Wsq) and good RF dissipation loss have been achieved. To the best of our knowledge these results are reported here for the first time.
Reasoning and Remembering

Field: Psychology (Social Sciences)

This investigation assessed the effectiveness of coaching active reasoning of students with learning disabilities. Sixty-three fourth- and fifth-grade students with learning disabilities were assigned at random to one of three treatment conditions: coaching, provided explanation, or no explanation control. In the coaching condition, students were provided factual information followed by a sequence of questions designed to help them construct explanations for the information. In the provided explanation condition, students were concurrently provided both the factual information and the associated explanations. Students in the no explanation control condition received only the target information. Results indicated that students in the coaching condition outperformed students in the two comparison conditions on immediate and 1-week delayed tests of both factual information and explanations. Further, it was found that a variety of levels of coaching support was required to lead students to construct their own explanations. Implications for future research and instruction for students with learning disabilities are discussed.
Biological aspects of two coexisting native and non-native fish species in the Aegean Sea: Pagellus erythrinus vs. Nemipterus randalli

Field: Agricultural and Biological Sciences (Life Sciences)

Nowadays, the Mediterranean is a hotspot of biodiversity, characterized by changes in fish communities due to invasions. These invasions, mainly occurring through the entrance of species through the Suez Canal, a process called Lessepsian migration, has been increasing in the last 40 years. It is reported that, in Turkish seas, where 512 fish species are found, are 75 Lessepsian species. However, knowledge about the impact of Lessepsian species on native species is insufficient. This study aims to determine the bio-ecological characteristics and food interactions of a native Pagellus erythrinus and non-native Nemipterus randalli distributed in the Gökova Bay.In the monthly sampling survey, carried out between January 2016 and December 2016, 1698 N. randalli and 945 P. erythrinus individuals were collected. Length, weight, age, sex distributions and ratios, length-age, weight-age, length-weight relationships, condition factors, stomach contents and reproduction periods were examined to determine the interaction between species. According to results, the life span of P. erythrinus is longer than N. randalli in the Gökova Bay. Nevertheless, N. randalli grows faster than P. erythrinus. Reproduction periods of both two species show similarities. Food competition between species is found to be significantly high. Results of condition factors exhibit that N. randalli shows an increased ability to exploit the available food sources. Pagellus erythrinus displays strategies such as: early maturation, short reproduction period, reproduction in the deeper waters and batch spawning, to compete with N. randalli. With the invasive characteristics of N. randalli established a successful population in the Gökova Bay.
Service-oriented middleware for collaborative UAVs

Field: Computer Science (Physical Sciences)

For a while, UAV (Unmanned Aerial Vehicles) use was limited to military applications, however recently UAVs are also used for a wide range of civilian applications. Some of the UAV applications may involve multiple UAVs that must cooperate to achieve a common task. This kind of applications is termed collaborative UAV applications. One of the main issues for multiple UAVs is developing an effective framework to enable the development of software systems for collaborative UAV operations. One possible approach is to rely on service-oriented computing and service-oriented middleware technologies to simplify the development and operations of such applications. This paper discusses the challenges of developing collaborative UAV applications and how the service-oriented middleware approach can help resolve some of these challenges. The paper also investigates the collaborative aspects of multiple UAVs and proposes a service-oriented middleware architecture that can satisfy the development and operations of such applications.
2,4-D mediated moderation of aluminum tolerance in Salvinia molesta D. Mitch. with regards to bioexclusion and related physiological and metabolic changes

Field: Agricultural and Biological Sciences (Life Sciences)

We examined the efficacy of 2,4-dichlorophenoxy acetic acid (2,4-D; 500 µM) in enhancing the potential of Salvinia species for tolerance to aluminum (Al) toxicity (240 and 480 µM, seven days). Salvinia showed better efficacy in removal of toxicity of Al by sorption mechanism with changes of bond energy shifting on cell wall residues and surface structure. Plants recorded tolerance to Al concentration (480 µM) when pretreated with 2,4-D through adjustment of relative water content, proline content, osmotic potential, and improved the pigment fluorescence for energy utilization under Al stress. Photosynthetic activities with regards to NADP-malic enzyme and malic dehydrogenase and sugar metabolism with wall and cytosolic invertase activities were strongly correlated with compatible solutes. A less membrane peroxidation and protein carbonylation had reduced ionic loss over the membrane that was studied with reduced electrolyte leakage with 2,4-D pretreated plants. Membrane stabilization was also recorded with higher ratio of K+ to Na+, thereby suggesting roles of 2,4-D in ionic balance. Better sustenance of enzymatic antioxidation with peroxidase and glutathione metabolism reduced reactive oxygen species accumulation and save the plant for oxidative damages. Moreover, gene polymorphism for antioxidant, induced by 2,4-D varied through Al concentrations would suggest an improved biomarker for tolerance. Collectively, analysis and discussion of plant's responses assumed that auxin herbicide could be a potential phytoprotectant for Salvinia as well as improving the stability to Al toxicity and its bioremediation efficacy.
The Analysis of Current Status and Contents of Parents and School Parents Education Materials in Government Departments: Focusing on the Comparison of the Materials from the Ministry of Education and the Ministry of Gender Equality and Family

Field: Social Sciences (Social Sciences)

이 연구의 목적은 교육부와 여성가족부가 개발한 (학)부모교육 자료의 현황 및 내용 분석을 통해 향후 정부 주도의 (학)부모교육 자료의 개발·보급 방향에 대한 시사점을 개발하는 데 있다. 2010년 이후 두 부처가 개발한 (학)부모교육 자료를 온·오프라인을 통해 수집하였으며, 최종적으로 교육부 자료 359종, 여성가족부 자료 163종을 수집하여 (학)부모교육 자료의 개발 시기, 교육내용, 교육대상, 자료보급형태 등을 분석하였다. 그 결과, 두 부처 모두 최근으로 올수록 (학)부모교육 자료를 많이 개발하였으며, 이는 관련 부처로서 (학)부모교육의 중요성을 인식한 결과라고 평가할 수 있다. 두 부처가 개발한 (학)부모교육 자료는 교육내용, 교육대상, 자료 개발 및 보급 주체, 자료형태, 접근성 수준에 따라 차이가 있었으며, 이러한 결과는 두 부처의 조직 체계, 교육과 보육 및 여성정책이라는 업무의 차이에 기인한 것으로 보인다. 연구결과를 통해 향후 (학)부모교육 자료의 개발이 지속적으로 이루어져야 하며, 그 과정에서 두 부처가 범정부 차원의 협력과 연계가 필요하다는 점을 도출하였다.The purpose of this study is to provide implications for development and distribution of parents and school parents education materials led by government. After collecting the education materials developed by the two ministries since 2010, 359 kinds of materials from the Ministry of Education and 163 kinds of materials from the Ministry of Gender Equality and Family were analyzed. As a result, both ministries developed more materials on parents and school parents education as they come recently, which can be evaluated as recognizing the importance of parents and school parents education as related ministries. The education materials developed by the two ministries differed in education contents and targets, subjects of material development and dissemination, material types, and accessibility levels, and this is interpreted to be due to differences in the organizational system and unique work of the two ministries. Based on these results, we draw that development of parents and school parents education materials should be continued in the future, and in the process, the two ministries need cooperation and linkage at government level.
Assessment of Good Practices in Community-Based Interventions for Physical Activity Promotion: Development of a User-Friendly Tool

Field: Health Professions (Health Sciences)

Tools to identify good practices in the design, implementation, and evaluation of physical activity community-based interventions (PACIs) are key to address the physical inactivity pandemic. Existing tools tend to be extensive and with limited applicability to assess small-scale PACIs. This work aimed to report the development and preliminary validity results of a simple, practical, and user-friendly tool to evaluate PACIs in local/municipal contexts. Eighty-six good practice characteristics defined by the World Health Organization (WHO), the Joint Action Framework on Chronic Diseases (CHRODIS), and an umbrella review of good practice characteristics of diet and physical activity interventions were initially extracted and refined in four rounds of revision from an expert panel using a Delphi-type methodology and rated on their relative importance. A pilot application was conducted, and data on the tool usability and applicability were collected through three semi-structured interviews with specialists and coordinators of local/municipal PACIs. For preliminary validation, the refined tool was applied to five community-based programs mostly aimed at an elderly population. The final tool included thirty-four selected characteristics, with a brief explanation and practical examples for each, under three main sections: design, evaluation, and implementation. Each characteristic has a rating (i.e., somewhat important, highly important, mandatory) and a percentage weight. Preliminary validation of this tool pointed to an adequate evaluation of good practice characteristics of municipal PACIs in a reliable, practical, and user-friendly way. Given its adequacy, this tool can support the definition of quality standards for PACIs, encouraging their dissemination and adoption at a regional or national level.
In vivo imaging and genetic analysis link bacterial motility and symbiosis in the zebrafish gut

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Complex microbial communities reside within the intestines of humans and other vertebrates. Remarkably little is known about how these microbial consortia are established in various locations within the gut, how members of these consortia behave within their dynamic ecosystems, or what microbial factors mediate mutually beneficial host–microbial interactions. Using a gnotobiotic zebrafish–Pseudomonas aeruginosa model, we show that the transparency of this vertebrate species, coupled with methods for raising these animals under germ-free conditions can be used to monitor microbial movement and localization within the intestine in vivo and in real time. Germ-free zebrafish colonized with isogenic P. aeruginosa strains containing deletions of genes related to motility and pathogenesis revealed that loss of flagellar function results in attenuation of evolutionarily conserved host innate immune responses but not conserved nutrient responses. These results demonstrate the utility of gnotobiotic zebrafish in defining the behavior and localization of bacteria within the living vertebrate gut, identifying bacterial genes that affect these processes, and assessing the impact of these genes on host–microbial interactions.
Introduction

Field: Social Sciences (Social Sciences)

This introductory chapter traces the history of the concept of the sexually deviant female in colonial India. It first takes a look at how the figure of the prostitute appears across different archives from colonial India and within analyses of Indian social life. The chapter then shows how colonial studies on the nature of Indian society were to become the empirical basis for universalist theories of comparative societies. Indeed, the colonial state in India was, at its inception, an experiment in new forms of scientific and social scientific practices that were to influence state practices and the formation of disciplinary knowledge in the colony and metropole. At the heart of these sciences of society was a concern about structuring, tracing, and mapping the social world of colonial India through the assessment of women's sexuality. These histories reveal the way key debates about gender, caste, communal difference, and social hierarchy in India became objects of social scientific analysis through the description and evaluation of female sexuality. And, as the chapter shows, this social scientific imaginary had extraordinary reach.
Social and non‐social sensory responsivity in toddlers at high‐risk for autism spectrum disorder

Field: Psychology (Social Sciences)

Abstract Empirical evidence concerning sensory responsivity in young children who later develop autism spectrum disorder (ASD) remains relatively limited. It is unclear whether specific patterns or aspects of sensory responsivity underlay the emergence of the disorder. The goals of this study were to (a) examine whether social versus non‐social context impacted the expression of sensory responsivity in infants at high risk for ASD, and (b) examine if sensory responsivity in social or non‐social contexts was associated with severity of ASD symptoms. The Sensory Experiences Questionnaire 2.1 was collected for 338 infants (131 females, 207 males) at high‐risk for ASD at 12 and/or 24 months of age. High‐risk toddlers meeting diagnostic criteria for ASD ( n = 75) showed elevated sensory responsivity in both social and non‐social contexts at 12 months of age and differences widened over the second year of life. Individuals with ASD demonstrate higher responsivity in both contexts suggestive of generalized atypical sensory responsivity in ASD. Lay Summary Behaviors such as avoiding or noticing sensory input (e.g., sounds, touches) are often different in individuals with autism spectrum disorder (ASD) than those without. The reason for this is widely unknown. The findings from this study show that in toddlers, sensory responsivity increased in both social and non‐social situations. Therefore, the setting of sensory input does not explain these differences.
Crimes in Archival Form: Human Rights, Fact Production, and Myanmar

Field: Social Sciences (Social Sciences)

Book Review| June 13 2023 Crimes in Archival Form: Human Rights, Fact Production, and Myanmar Crimes in Archival Form: Human Rights, Fact Production, and Myanmar. By Ken Maclean. Berkeley: University of California Press, 2022. xiv, 284 pp. ISBN: 9780520385412. Jane M. Ferguson Jane M. Ferguson Australian National University jane.ferguson@anu.edu.au Search for other works by this author on: This Site Google Journal of Asian Studies 10849812. https://doi.org/10.1215/00219118-10849812 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn Email Permissions Search Site Citation Jane M. Ferguson; Crimes in Archival Form: Human Rights, Fact Production, and Myanmar. Journal of Asian Studies 2023; 10849812. doi: https://doi.org/10.1215/00219118-10849812 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsJournal of Asian Studies Search Advanced Search The text of this article is only available as a PDF. © 2023 Association for Asian Studies2023 Article PDF first page preview Close Modal You do not currently have access to this content.
Evaluation of the ability of Pichia guilliermondii to improve growth performance and disease resistance in rainbow trout (Oncorhynchus mykiss)

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract This study examined supplementation of a novel yeast product containing Pichia guilliermondii on juvenile rainbow trout, Oncorhynchus mykiss , growth, and disease resistance. In two separate trials, fish (initial weight 6.2 and 10.6 g, respectively), were fed an extruded diet (41% digestible protein and 18% crude lipid) supplemented with 0.3 or 0.6% P. guilliermondii alone or 0.3% P. guilliermondii with a dietary gut supplement at 0.1%. Prior to the end of each trial, a subsample of fish from each tank was exposed by immersion to Yersinia ruckeri (Trial 1) or injection with Flavobacterium pyschrophilum (Trial 2). At the conclusion of the trials, supplementation of either P. guilliermondii or the gut supplement improved growth and food conversion efficiency in rainbow trout when fed for 16‐weeks. No effects of supplementation on mortality were observed. These results suggest potential as functional additives; however, additional investigation regarding the efficacy of whole‐cell and disrupted wall components of P. guilliermondii is needed to better assess their potential effects on rainbow trout immune responses.
Polymorphism Diacylglycerol Acyltransferase 1 (DGAT1) Gene in Bali Cattle

Field: Agricultural and Biological Sciences (Life Sciences)

Bali cattle is a native cattle from Indonesia that has tremendous potential to be developed. However, the utilization is not yet optimal. Carcass quality is one of the unoptimized traits and molecular approach is used to study this trait. One of the markers that can be used to study carcass quality is Diacylglycerol Acyltransferase 1 (DGAT) gene. The purpose of this study was to identify the diversity of Diacylglycerol Acyltransferase 1 (DGAT) gene in Bali cattle at Bali Cattle Breeding Center. Sequencing method and defining the right SNP on the target fragment of DGAT1 gene were used for this study. The number of samples used in this study were 48 heads of Bali cattle consisting of 24 males and 24 females. Primer DGAT1 gene amplification used forward 5'-CACCATCCTCTTCCTCA-3’ and reverse 5'-GGAAGCGCTTTCGGATG-3'. Identification of DGAT1 gene diversity was conducted by direct sequencing of allele and genotype methods. Hardy-Weinberg balance was calculated by GENEPOP (V3.2). The result of analysis found SNP in DGAT1 gene in Bali cattle. There were SNP c.10433G> A and c.10434C> A, but they were monomorphic.
Study on Patient Satisfaction Survey under Custom Satisfaction Model in Medical Service Vocation

Field: Health Professions (Health Sciences)

Objective To study on patient satisfaction survey under custom satisfaction model in medical service vocation.Meth- ods Design the inpatient satisfaction survey.165 inpatients were selected randomly to fill in the survey.Results The general satisfaction of inpatient is 82.4%,the satisfaction to indication doctor is 90.3%,the satisfaction to nurse is 86.9%,the satisfac- tion to management of hospital is 70.66%,and the satisfaction to logistics is 63.03%.The return rate to hospital is 76.4%. Conclusion Through the patient satisfaction survey,problems can be find so as to resolve the problems,improve the service process,transform the service attitude and construct harmony relationship between doctors and patients.
Cardiac abnormalities detection from compressed ECG in wireless telemonitoring using principal components

Field: Computer Science (Physical Sciences)

In wireless telecardiology applications ECG signal is compressed before transmission to support faster data delivery and reduce consumption of bandwidth. However, most of the ECG analysis and diagnosis algorithms are based on processing of the original ECG signal. Therefore, compressed ECG data needs to be decompressed first before the existing algorithms and tools can be applied to detect cardiovascular abnormalities.
Full-Endoscopic Spinal Surgery for Older Patients With Degenerative Spinal Pathology: A Narrative Review

Field: Medicine (Health Sciences)

The aging population worldwide is experiencing an increasing incidence of degenerative spinal disorders, leading to significant morbidity and diminished quality of life. Traditional open surgical approaches for treating these conditions in older patients often entail substantial risks and prolonged recovery times. However, recent advancements in endoscopic surgical techniques have provided promising alternatives with potentially reduced morbidity and quicker recovery. This paper reviews the current literature regarding full-endoscopic spinal surgery (FESS) for degenerative spinal pathology in older patients. We discuss the evolution of endoscopic techniques, patient selection criteria, surgical indications, outcomes, and complications associated with FESS in older adults. Several studies have reported favorable outcomes of FESS in older patients, including reduced postoperative pain, shorter hospital stays, faster recovery, and comparable or even improved clinical outcomes compared with traditional open surgery. Moreover, FESS offers the advantages of minimal tissue disruption, preservation of spinal stability, and decreased blood loss, which are particularly advantageous in older patients with multiple comorbidities. However, challenges such as a steep learning curve for surgeons, limited visualization, and technical constraints in managing complex pathologies remain significant concerns. Additionally, the long-term durability and effectiveness of FESS in older patients require further investigation. In conclusion, FESS presents a promising minimally invasive option for treating degenerative spinal pathology in older adults. Further research and technological advancements are needed to optimize patient selection, refine surgical techniques, and improve long-term outcomes in this growing demographic category of patients.