jimnoneill/paper-to-field-training huggingface dataset:
Printed in U.S.A. Cytisine-Based Nicotinic Partial Agonists as Novel Antidepressant Compounds

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Nicotine and other nicotinic agents are thought to regulate mood in human subjects and have antidepressant-like properties in animal models. Recent studies have demonstrated that blockade of nicotinic acetylcholine receptors (nAChRs) including those containing the �2 subunit (�2*), results in antidepressant-like effects. Previous studies have shown that cytisine, a partial agonist at �4/�2 * nAChRs, and a full agonist at �3/�4* and �7 nAChRs, has antidepressant-like properties in several rodent models of antidepressant efficacy; however, it is not clear whether more selective partial agonists will also be effective in these models. We tested cytisine and two derivatives, 5-bromo-cytisine (5-Br-Cyt) and 3-(pyridin-3�-yl)-cytisine (3pyr-Cyt) for their ability to act as a partial agonist of different nAChR subtypes and to show antidepressant-like activity in
Hydrosocial Territories Research: An Overview

Field: Social Sciences (Social Sciences)

ABSTRACT Hydrosocial territories scholarship has contributed to advancing relational, power‐sensitive, multiscalar understandings of water and its governance. Grounded in critical water studies, political ecology, and political geography, this scholarship draws attention to how water distributions are contested between different interest groups and their respective notions of how water is and should be governed at multiple interrelated spatial and temporal scales. We provide an overview of the literature on hydrosocial territories with the objective of tracing the development and application of this framework since its introduction in the mid‐2010s. The article summarizes how hydrosocial territories research has developed conceptually, methodologically, and thematically. We find that hydrosocial territories research employs largely qualitative methodologies to study water‐related disputes surrounding a diversity of themes including hydraulic infrastructures, agricultural production and export, urbanization, river basin management, extractive industries, and conservation. We conclude with a reflection on potential ways forward for hydrosocial territories scholarship.
[Reliable parameters for assessing the birefringence of retinal nerve fiber layer under various conditions of corneal birefringence].

Field: Medicine (Health Sciences)

Although the measurement of the retinal nerve fiber thickness itself depends largely on the location in the birefringent cornea through which the laser beam passes, the ratios of nerve fiber layer thickness such as temporal-to-nasal or superior-to-inferior are reliable and show less fluctuation in the measured values.
A Safe Place: Jane Austen and the Richardsonian Inheritance

Field: Arts and Humanities (Social Sciences)

Jane Austen's novels have often been viewed as realistic portrayals of the time in which she lived. This paper attempts to modify this view by examining her work in the context of the novels of Samuel Richardson, the writer whom she reportedly admired above all others. There are many differences between the two authors, but their subject matter is essentially the same: the hearts and minds of marriageable young women. Richardson's heroines, however, are threatened and harassed while Austen's are free to experience without fear, and to learn without danger. In "Sir Charles Grandison or The Happy Man", a parody she wrote of Richardson's Sir Charles Grandison, Austen satirizes Richardson's timorous heroines and aggressive heroes; in her novels, women are self-assured and men are not frightening. An examination of the social history of the eighteenth ce ntu ry and the letters of Jane Austen, however, demonstrates that the world of her novels is not the one she knew. Her much misunderstood letters, in particular, show that her attitudes towards sexual relationships have much in common with those of Samuel Richardson. In addition, her letters illustrate the source and significance of her celebrated irony. Finally, this study concentrates on Mansfield Park, the novel that appears to contradict Austen's other novels. Mansfield Park is didactic and unironic; it has an oppressed heroine, powerful male characters, and a society that neither appreciates nor defends women. In Mansfield Park the Richardsonian inheritance and Austen's social and sexual views come together and provide insights into her work. Jane Austen's heroines, with the exception of Fanny Price, inhabit a safe place she creates for them. Her rejection of the dangers of women's lives, which Richardson depicts so well, is proof, not of her realism, but of her artistry.
THE DIVERSITY OF YOUTH REVIEWED

Field: Social Sciences (Social Sciences)

Phil Cohen, Rethinking the Youth Question: Education, Labour and Cultural Studies. London: Macmillan, 1997, £16.99, xi+414 pp. (ISBN 0-333-63148-X).Andy Furlong and Fred Cartmel, Young People and Social Change: Individualisation and Risk in Late Modernity. Buckingham: Open University Press, 1997, £45.00 (£14.99 pbk), viii+141 pp. (ISBN 0-335-194-656 hbk, 0-335-19464-8 pbk).H. Decker Scott and Barrick Van Winkle, Life in the Gang: Family, Friends and Violence. Cambridge: Cambridge University Press, 1996, £45.00 (£15.95 pbk), xi+303 pp. (ISBN 0-521-56292-9 hbk, 0-521-56566-9 pbk).John Hagan and Bill McCarthy, Mean Streets: Youth Crime and Homelessness. Cambridge: Cambridge University Press, 1997, £40.00 (£14.95 pbk), xv+299 pp. (ISBN 0-521-49743-4 hbk, 0-521-646-26X pbk).Mihaly Csikszentmihalyi, Kevin Rathunde and Samuel Whalen (with contribution by Maria Wong), Talented Teenagers: The Roots of Success and Failure. Cambridge: Cambridge University Press, 1997, £14.95, x+307 pp. (ISBN 0-521-57463-3 pbk).Historically there have been continuing concerns about the everyday lives of young people which have been voiced vociferously by the press, politicians and the public alike. These concerns have oscillated along the careöcontrol continuum and reflect both political and personal confusions about the daily lives of young people and how they as both individuals and a group, in turn make sense of the social, political and economic structures created for them by ‘adult’ society. These ‘concerns’ have not always been reflected by academic writing and research, which has struggled over whether ‘youth’ were worthy of special attention in the first place or whether such writing should be integrated into general research and teaching.
RELIABILITY ASSESSMENT AND IMPROVEMENT OF 11KV DISTRIBUTION SYSTEM WITH DISTRIBUTED GENERATION DEPLOYMENT

Field: Engineering (Physical Sciences)

Interruptions which are largely unavoidable contribute to the unavailability of power and the inability of the power system meeting the electricity demands of the consumers. The incessant interruptions and unstable power supply from the grid could be as a result of unreliable nature of the distribution system, which is unhealthy to the consumers, power system equipment and the utility company. Therefore, to minimize this unreliability issues, the power system planners need comes up with an upgrading approach with a view of improving the reliability of the distribution system. In this paper, reliability assessment of Okwuzi, Omoku 11kV distribution system was carried out using one year (January to December,2023) outage frequency and duration data gotten from the utility, in order to ascertain the reliability performance of the system by determining key reliability indices, and proposes penetration of distributed generation if the indices fail the set standard. Electrical Transient Analyzer Program (ETAP) software was used for the simulation. This was done by carrying out reliability study of the existing 11kV distribution network using embedded analytical equations in ETAP; reliability indices were determined, and improved upon by the penetration of PSO optimized distributed generation (1.63MVA) in bus 9 and reliability study was performed with DG. The results obtained indicate that when DG was injected into the system, average failure rate and average outage duration at load point 6, reduces by 34.2% and 23.8% respectively, then, so on up to load point 14. Similarly, at the penetration of DG, there were significant improvement in the customer’s-oriented reliability indices; SAIFI, 0.4747 to 0.2535f/yr, SAIDI, 13.56 to 8.2585hr/yr, CAIDI, 32.577 to 28. 581hr.intr and EENS, 56.216 to 43.376MWhr/yr. The availability index ASAI improved from 86.8 % to 99.85% which is close to the 99.9989% IEEE benchmark
Alzheimer's disease: maintenance of neuronal and synaptic densities in frontal cortical layers II and III

Field: Neuroscience (Life Sciences)

Neuronal loss and alterations of the cortical neuropil were previously described on necropsic material from patients with senile dementia of the Alzheimer type, and the results compared to age-matched case controls. In frontal cortex biopsic material from our patients with Alzheimer's disease, the numerical densities of neurons and synapses were not significantly different from controls, indicating that changes in the highest cognitive functions might not depend on a generalized loss of neurons and synapses and that quantitative morphological differences may exist between Alzheimer's disease and senile dementia of the Alzheimer type.
Characterization, Optimization, and Fabrication of Phase Change Material Germanium Telluride Based Miniaturized DC–67 GHz RF Switches

Field: Materials Science (Physical Sciences)

This paper presents the characterization, optimization, and fabrication of phase change material (PCM) germanium telluride (GeTe) based RF switches investigating the materials' aspect and design parameters of the switches and their impact on the RF performance. Surface properties of GeTe thin films are investigated through atomic force microscopy (AFM), scanning electron microscopy (SEM), and cross-wafer resistance mapping measurements. Optimized GeTe thin films exhibit over five orders of resistance change. Various GeTe switch design constraints are studied via cross sectioning of the fabricated device using a focused ion beam (FIB)-SEM. Current-carrying capacity and resistance of microheaters are extracted using electrical characterization. The RF performance of the PCM switches is optimized using diverse design parameters and characterization of PCM thin films. A six-layer microfabrication process is presented for monolithically integrating RF circuits with PCM switches. Methods to reduce parasitic elements in PCM switches are discussed. The RF performance of the optimized PCM based switch is simulated and measured demonstrating better than 0.4 dB of insertion loss and a return loss better than 20 dB from dc to 67 GHz.
Antibiotic use in pre-school children and the correlation with adult educational levels in two Nordic counties: a replication of a 20-year-old study

Field: Medicine (Health Sciences)

We found higher antibiotic prescribing in pre-school children in the municipalities of Copenhagen County compared to Skåne County in 2017, suggesting a possible overuse of antibiotics in Denmark. Further research should try to elucidate the reasons for the observed variation.
Issues in Regulatory Progress of Biosimilars-An Update

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

In the last ten years bio similar program have progressed significantly both in EU and US.Several products were approved by these Agencies as shown in Table 1.Several submissions are pending to be approved.In the meantime FDA issued two important long waited guidance [1-3]: one on labeling and the other one in inter changeability of drug product.Several organizations from both countries commented on the labelling and inter changeability [3][4][5].According to these comments it is important to provide complete, accurate, transparent prescribing and dispensing information of bio similar and interchangeable biological products [5][6][7][8][9].If the information is limited about the bio similar product in the labeling for that particular product it is difficult for healthcare providers to prescribe safely and effectively.Several considerations are required to maintain good supply chain reliability and patient support programs.In case of the post-approval requirements, both EMA agree that the post approved biosimilar is not linked to the reference product.Furthermore, any changes to the product have to be evaluated in accordance with the post-approval guidance.The FDA, on the other hand, is working on post-approval guidance for biosimilar products.The above issues are also reflected in a few approved biosimilars.In order to bring more confidence in these biosimilar products new approaches are required to perform post approval research on the safety and effectiveness of biosimilars compared with their branded products.
New for flora of Leningrad Region and Russia species of Chrysophyta

Field: Agricultural and Biological Sciences (Life Sciences)

Original descriptions and photographs of new to the flora of the Leningrad Region 7 chrysophycean species found in a wetland of international importance “Mshinskaya Wetland System” are presented. Two species — Mallomonas asmundiae and M. pseudocratis — are recorded for the first time in Russia.
A study on the tourism experiences of tourists with infants and young children from an accessible tourism perspective: Focusing on participants with experience in tourism activities

Field: Social Sciences (Social Sciences)

This study aimed to investigate the tourist experience of individuals who travel with infants and young children from the perspective of accessible tourism using online written interviews. Colaizzi's (1978) descriptive phenomenology was used as the research method, categorizing data into 6 categories, 17 theme clusters, and 73 themes. Specifically, the study examined reasons for participating in tourism, satisfaction with tourism activities, the usefulness of parents' prior experience, considerations when engaging in tourism with infants, difficulties encountered, and strategies for overcoming these difficulties. Difficulties and strategies for overcoming them were identified within the 17 theme clusters. The findings revealed that individuals participate in tourism activities to escape their daily routines, seek new experiences, and fulfill their parental roles. Although challenges such as limited mobility and lack of convenient facilities were noted, these were viewed as obstacles that could be easily overcome by the accompanying parents. This research highlights that individuals traveling with infants and young children perceive the limitations of tourism activities as unique conditions associated with traveling with young ones, differing from previous studies. Effective strategies for overcoming difficulties included diversifying information acquisition, engaging in actions to relax psychologically, and recognizing the uniqueness of the situation. Through this experiential process, parents were able to strengthen family bonds and derive satisfaction from the joy experienced by their children, resulting in a positive and fulfilling experience. These research findings contribute to a better understanding of the tourist experience for individuals traveling with infants and young children and offer important academic implications.
METACOGNITION IN THE 21st CENTURY ESL TEACHER EDUCATION PROGRAMME

Field: Arts and Humanities (Social Sciences)

This paper presents the discussion on the role of metacognitive strategies in the 21 st century ESL teacher education programme. It examines the kinds of teaching and learning experiences that enable the student teachers to develop their metacognitive strategies.. This paper draws relevant examples of a classroom based practice from student teachers’ assignments to reflective journal entries, participant observation, field notes, and feedback and evaluation forms. Data analysis was carried out qualitatively. The findings revealed that reflective journal entries, commenting, providing and giving feedback, dialogic interactions as well as whole class discussions through questions and answers are among the activities that could enable student teachers develop their metacognitive strategies. This study implicates the need for ESL teacher education programmes to provide teaching and learning experiences that are transformative in nature in order to develop prospective ESL teachers who are adaptive, self-reliant and independent, resourceful, innovative and reflective.
Hybrid manufacturing of collector coins with free-moving features

Field: Engineering (Physical Sciences)

This paper presents a feasibility study on the use of hybrid manufacturing to fabricate collector coins with free-moving features. The approach begins with the fabrication of the different coin elements through blanking and additive manufacturing and ends with minting to connect these elements and impart lettering and reliefs on both coin surfaces. Two different concepts are introduced and analyzed based on the geometric and operative parameters of coin minting. Experiments and finite element computer simulations allow establishing the applicability window of the proposed coin concepts. These results, combined with those obtained from destructive tests, are then used to optimize the operative parameters concerning the final geometry and structural integrity of the coins. The feasibility of the new hybrid manufacturing approach is demonstrated through the fabrication of prototype coins with free-moving features.
Our experience with a single stage bilateral approach for treatment of bilateral middle cerebral artery aneurysms

Field: Medicine (Health Sciences)

Surgical management of bilateral middle cerebral artery (MCA) aneurysms is particular challenging clinical situation. For these patients various options of surgical treatment are available as unilateral approach, single stage bilateral craniotomy or two stage bilateral craniotomy. We report our experience with a case of bilateral MCA aneurysm which was managed by single stage bilateral pterional craniotomy.
Failure of an Antihistamine Drug to Influence the Course of Experimental Human Burns

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

TENDENCIESBMsi 57 choice can lie in only one direction if the profession is to retain an honoured place in the community.The British Medical Association, with its far-flung interests and its con- siderable influence, is well fitted and equipped to meet any challenge which threatens the rectitude of the profession.With unity of purpose, unshakable confidence, and sound medical statesmanship, success can be assured, for we yield to none in our devotion to our profession.Meanwhile "Let us, then, be up and doing.With a heart for any fate Still achieving, still pursuing, Learn to labour and to wait.
Contact Processes in Grinding

Field: Engineering (Physical Sciences)

The relevance of investigating the problem of loading a diamond abrasive tool with a metallic binder to improve the efficiency of finishing treatment of a wide range of high-strength materials is addressed in the paper. The results of theoretical and experimental studies of the formation of a greasy layer on the surface of diamond wheels in the treatment of high-strength materials are shown. In the theoretical part it is proposed to consider this phenomenon in terms of the equilibrium state of electrochemical potentials at the interface of a diamond wheel and the treated surface. Dependences are revealed that help to determine greasy layer values. The practical part of this work consists in electron-microscopic, spectroscopic and X-ray diffraction studies of wheel specimens with a metallic binder in diamond grinding. Based on the results obtained the composition and structure of a greasy layer are determined. A comparison of the experimental data with the calculated values confirms the adequacy of the proposed theory. The use of combined methods to improve the efficiency of machining high-strength materials is recommended. It can help to reduce the intensity of loading and to improve the cutting properties of diamond abrasive tools with a metallic binder
Being Together in Time: Musical Experience and the Mirror Neuron System

Field: Neuroscience (Life Sciences)

THE DISCOVERY OF INDIVIDUAL "MIRROR NEURONS" in the macaque brain that fire both when an action is executed and when that same action is observed or heard, and of a homologous system in humans, is leading to an extraordinary conceptual shift in our understanding of perception-action mechanisms, human communication, and empathy. In a recent model of emotional responses to music (Molnar-Szakacs & Overy, 2006), we proposed that music is perceived not only as an auditory signal, but also as intentional, hierarchically organized sequences of expressive motor acts behind the signal; and that the human mirror neuron system allows for corepresentation and sharing of a musical experience between agent and listener. Here, we expand upon this model of Shared Affective Motion Experience (SAME) and discuss its implications for music therapy and special education.We hypothesize that imitation, synchronization, and shared experience may be key elements of successful work in these areas.
Cincinnati, Ohio

Field: Social Sciences (Social Sciences)

STREETS: Acomb Ave.; Aikenside Ave. [3600-3659]; Amy Ave.; Blaesi [5000-5129]; Camargo [5000-5149]; Chandler [5400-6525]; Chapman [5100-5415]; Congreve Ave.; Conway; Cornish; Dahlgren; Darling Road; Davenant Ave.; Davies Place; Deerfield Road; Desmond [5800-6525]; Dickens Ave. [3620-3655]; Dora [5300-5315]; Durner Ave.; East Fork Ave. [6700-6848]; East Ledge [6500-6719]; Ebersole Ave. [5200-5525]; Gelert Ave.; Glenshade Ave. [5000-5215]; Gomien Ave. [5000-5315]; Hanks Alley; Jameson Place [5000-5025]; Kennedy Ave. [5800-5925]; Kinolly Ave. [5700-5835]; Luhn Ave.; Madison Road [5400-6616]; Manuel [6200-6221]; Mathis [5000-5125]; Morning Ave.; O'Mera [3300-3335]; O'Mera [5800-5949]; Onondaga Ave.; Owasco [5300-5435]; Pandora Ave.; Portman Ave.; Ridge Ave. [5600-5740]; Roanoke [5000-5225]; Sierra Park [5800-6335]; Stewart Place [5000-5515]; Valley View Ave. [5700-5855]; Ward [5000-5425]; Weltner [5300-5355]; Whetsel Ave. [5000-5525]; Wistaria; Woodford Road [3241-3825]; Wyatt Ave. [5700-5875]; Yononte Ave.
Scholastic Magic: Ritual and Revelation in Early Jewish Mysticism

Field: Arts and Humanities (Social Sciences)

Book Review| April 01 1999 Scholastic Magic: Ritual and Revelation in Early Jewish Mysticism Scholastic Magic: Ritual and Revelation in Early Jewish Mysticism, Michael D. Swartz. David Frankfurter David Frankfurter Search for other works by this author on: This Site Google Journal of Biblical Literature (1999) 118 (1): 142–144. https://doi.org/10.2307/3268239 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation David Frankfurter; Scholastic Magic: Ritual and Revelation in Early Jewish Mysticism. Journal of Biblical Literature 1 January 1999; 118 (1): 142–144. doi: https://doi.org/10.2307/3268239 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveSBL PressJournal of Biblical Literature Search Advanced Search The text of this article is only available as a PDF. Article PDF first page preview Close Modal Issue Section: Book Reviews You do not currently have access to this content.
Combinatorial RNAi: a method for evaluating the functions of gene families in Drosophila

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

spinal cord. Habgood pointed out thatcarrier mechanisms, such as Penetratin,might provide an effective barrier-passingmechanism if they are targeted to cerebralendothelial cells. Tony Hughes (Universityof Melbourne, Australia) dealt with the useof a naturally occurring system for braintargeting (BDNF peptide fragments), andDavid Begley (King’s College London, UK)described the