jimnoneill/paper-to-field-training huggingface dataset:
Specific Identification of Glycoproteins Bearing the Tn Antigen in Human Cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Glycoproteins contain a wealth of valuable information regarding the development and disease status of cells. In cancer cells, some glycans (such as the Tn antigen) are highly up‐regulated, but this remains largely unknown for glycoproteins with a particular glycan. Herein, an innovative method combining enzymatic and chemical reactions was first designed to enrich glycoproteins with the Tn antigen. Using synthetic glycopeptides with O‐GalNAc (the Tn antigen) or O‐GlcNAc, we demonstrated that the method is selective for glycopeptides with O‐GalNAc and can distinguish between these two modifications. The diagnostic ions from the tagged O‐GalNAc further confirmed the effectiveness of the method and confidence in the identification of glycopeptides with the Tn antigen by mass spectrometry. Using this method, we identified 96 glycoproteins with the Tn antigen in Jurkat cells. The method can be extensively applied in biological and biomedical research.
Computer science: Key to a space program renaissance. The 1981 NASA/ASEE summer study on the use of computer science and technology in NASA. Volume 2: Appendices

Field: Computer Science (Physical Sciences)

Adoption of an aggressive computer science research and technology program within NASA will: (1) enable new mission capabilities such as autonomous spacecraft, reliability and self-repair, and low-bandwidth intelligent Earth sensing; (2) lower manpower requirements, especially in the areas of Space Shuttle operations, by making fuller use of control center automation, technical support, and internal utilization of state-of-the-art computer techniques; (3) reduce project costs via improved software verification, software engineering, enhanced scientist/engineer productivity, and increased managerial effectiveness; and (4) significantly improve internal operations within NASA with electronic mail, managerial computer aids, an automated bureaucracy and uniform program operating plans.
4 &amp;#215; 4 bit GaAs DCFL parallel multiplier

Field: Engineering (Physical Sciences)

A 4×4 bit GaAs DCFL parallel multiplier (1.7 × 1.9 mm 2 ), which integrates 187 E-FETs and 87 D-FETs, has been fabricated. The array architecture with the "carry-save" algolithm was selected in the multiplier circuit design. Full and half adders were implemented with AND/NOR gates which saved the total number of gates and power dissipation. Test device was fabricated by Pt buried-gate planar process. Typical multiplication time of 5.5 - 6.5 ns was achieved at power dissipation of 39 mW using 1.4- \micro m gate FETs.
Treatment of schizophrenia complicated by catatonia with clozapine in a 16 year old asylum seeker

Field: Medicine (Health Sciences)

Abstract In this case report, we describe the clinical course of a 16 yr old asylum seeker from Afghanistan who developed paranoid schizophrenia complicated by catatonia and was successfully treated with diazepam and clozapine. To our knowledge, this is the first case report of its kind in this age group. Our patient became psychotic and presented to A&E after cutting off the tip of his nose in response to command hallucinations telling him to kill himself, his mother and his siblings. His catatonic features, which emerged after hospitalization, were those of mutism, akinesia, posturing including the psychological pillow. He did not respond to risperidone or haloperidol; showed a partial response to lorazepam and diazepam. His catatonic features and psychosis only resolved upon the introduction of clozapine. We go on to review the literature about catatonia in children and adolescents. We discuss the nosological dilemma with classification, the evolution of treatments and the role of anti-psychotic medication in the treatment of catatonia. Specifically, we advocate the usefulness of clozapine as an adjunct and as monotherapy.
Energy Transition Modelling in Iran: An Evidence from the ARDL Bound Testing Method

Field: Energy (Physical Sciences)

The challenge of environmental pollution and climate change have made countries to develop energy transition progress to move from non-renewable energy sources towards renewable ones. This paper seeks to consider energy transformation process and analyze its pattern in Iran by modeling through the ARDL bounding testing method over the period of 1993-2018. The empirical estimations depicted that in the long-run economic growth and inflation rate negatively impact on energy transformation of Iran, while increase in carbon dioxide emissions and appreciation of Iran’s national currency accelerate the energy transition process in Iran. Regarding the short-run relationship, the major results represented an evidence of positive impact of exchange rate on Iran’s energy transition process, while the other variables have negative coefficient. As a major concluding remark, for the case of Iran, the findings prove that the influential impacts of explanatory variables on energy transformation are stronger in long-run rather than in short-run. Therefore, the presence of efficient long-run energy planning is recommended.
Methodological rigor of corporate governance studies: A review and recommendations for future studies

Field: Business, Management and Accounting (Social Sciences)

Abstract Manuscript Type Article/Review Research Question/Issue This study presents the results of a longitudinal content analysis of governance articles published in both CGIR and other leading management outlets. Our aim with this review is to identify problematic areas, as well as opportunities to improve the methodological rigor of governance studies. Research Findings/Insights We examine key design aspects of corporate governance articles. We identify and compare trends (1) over time and (2) across publishing outlets. Specifically examined are the geographic scope of samples, design characteristics (i.e., single‐ versus multi‐year data, the use of archival, survey, experimental, and qualitative designs, data sources, and reliance on concurrent versus longitudinal data), survey response rates and the use of tests for non‐response bias, the statistical analysis techniques used, reporting of results (number and proportion of hypotheses supported, non‐significant, and counter‐significant, use of statistical power analysis, reporting of descriptive statistics and correlations, use and significance of control variables, and endogeneity controls), and the sophistication of the models tests (i.e., mediation and moderation). Theoretical/Academic Implications Based on the results of the review, recommendations for academic researchers are offered in the following areas: (1) designing theoretical tests which both incorporate and go beyond main effects; (2) evaluating a research design's analytical parameters on an a priori basis to maximize reliability, validity, and the potential for publication; (3) incorporating assessment of sensitivity and robustness checks into the analysis; and (4) comprehensive reporting of results including post hoc power analysis, complete and expanded correlation matrix(es), reporting and assessing counter‐results, and avoiding HARKing.
Controlled synthesis of peptides in aqueous medium. III. Use of Leuch's anhydrides in the synthesis of di-peptides. Mechanism and control of side reactions

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTControlled synthesis of peptides in aqueous medium. III. Use of Leuch's anhydrides in the synthesis of di-peptides. Mechanism and control of side reactionsRalph F. Hirschmann and Cite this: J. Org. Chem. 1967, 32, 11, 3415–3425Publication Date (Print):November 1, 1967Publication History Published online1 May 2002Published inissue 1 November 1967https://pubs.acs.org/doi/10.1021/jo01286a030https://doi.org/10.1021/jo01286a030research-articleACS PublicationsRequest reuse permissionsArticle Views738Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Yong Vui Kong v. Public Prosecutor (Sing. Ct. App.)

Field: Arts and Humanities (Social Sciences)

On March 4, 2015, Singapore’s Court of Appeal issued its judgment in Yong Vui Kong v. Public Prosecutor , upholding the punishment of caning imposed on the defendant as constitutional. The decision is significant because it discusses the impact of the prohibition of torture, a peremptory norm of international law, on domestic legislation. The Court of Appeal determined that, even if caning were to be considered a form of torture, the customary international law prohibition on torture did not invalidate its domestic law permitting caning as a form of punishment.
Bone health in childhood low grade glioma; an understudied problem

Field: Medicine (Health Sciences)

Objective: Children with a supratentorial midline low grade glioma (LGG) may be at risk for impaired bone health due to hypothalamic-pituitary dysfunction, obesity, exposure to multiple treatment modalities, and/or decreased mobility. The presence of impaired bone health and/or its severity in this population has been understudied. We aimed to identify the prevalence and risk factors for bone problems in children with supratentorial midline LGG. Design and Methods: A retrospective study was performed in children with supratentorial midline (suprasellar or thalamic) LGG between 1-1-2003 and 1-1-2022, visiting the Princess Máxima Center for Pediatric Oncology. Impaired bone health was defined as presence of vertebral fractures and/or very low bone mineral density (BMD). Results: In total, 161 children were included, with a median age at tumor diagnosis of 4.7 years (range 0.1 – 17.9) and a median follow-up of 6.1 years (range 0.1 – 19.9). Five patients (3.1 %) had vertebral fractures. In 99 patients BMD was assessed either by Dual Energy X ray Absorptiometry (n=12) or Bone Health Index (n=95); 34 patients (34.3%) had a low BMD (≤ -2.0). Impaired visual capacity was associated with bone problems in multivariable analysis (OR 6.63, 95% CI 1.83 – 24.00, p = 0.004). Conclusions: In this retrospective evaluation, decreased BMD was prevalent in 34.3% of children with supratentorial midline LGG. For the risk to develop bone problems visual capacity seems highly relevant. Surveillance of bone health must be an aspect for awareness in the care and follow-up of children with a supratentorial midline LGG.
Carbon Monoxide Intoxication: Diagnostic Considerations

Field: Medicine (Health Sciences)

To the Editor.—

The New Mexico Health and Environment Department and the New Mexico Poison Center frequently become involved in the investigation of accidental carbon monoxide (CO) intoxications. These investigations suggest that physicians should be reminded of three diagnostic considerations: the symptoms and time clustering of CO intoxications can be similar to those of food poisoning; a cherry red color of the skin and mucous membranes is not always present in CO intoxications; and some qualitative laboratory tests for carboxyhemoglobin (COHb) will not detect abnormal values. Group exposures to carbon monoxide may be misdiagnosed as food poisoning, especially if vomiting is present. As an example, we were requested to evaluate the conditions of a husband and wife and their 18-month-old son for presumed food poisoning. Both parents complained of nausea, vomiting, headache, dizziness, severe abdominal cramps, and diarrhea. The husband had experienced blurred vision and the wife had fainted. The
Therapeutic Modulation of Prostate Cancer Metastasis

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Targeting prostate cancer metastasis has very high therapeutic potential. Prostate cancer is the second most common cause of cancer death among men in the USA, and death results from the development of metastatic disease. In order to metastasize, cancer cells must complete a series of steps that together constitute the metastatic cascade. Each step therefore offers the opportunity for therapeutic targeting. However, practical limitations have served as limiting roadblocks to successfully targeting the metastatic cascade. They include our still-emerging understanding of the underlying biology, as well as the fact that many of the dysregulated processes have critical functionality in otherwise normal cells. We provide a discussion of the underlying biology, as it relates to therapeutic targeting. Therapeutic inroads are rapidly being made, and we present a series of case studies to highlight key points. Finally, future perspectives related to drug discovery for antimetastatic agents are discussed.
Confidential Data Identification Using Data Mining Techniques in Data Leakage Prevention System

Field: Computer Science (Physical Sciences)

Data leakage means sending confidential data to an unauthorized person. Nowadays, identifying confidential data is a big challenge for the organizations. We developed a system by using data mining techniques, which identifies confidential data of an organization. First, we create clusters for the training data set. Next, identify confidential terms and context terms for each cluster. Finally, based on the confidential terms and context terms, the confidentiality level of the detected document calculated in terms of score. If the score of the detected document beyond a predefined threshold, then the document is blocked and marked as a confidential.
Boosting the Impact of Nepal’s Child Grant through a Parenting Intervention

Field: Social Sciences (Social Sciences)

This paper provides the results gathered over two years of Save the Children’s parenting programme developed for the Government Child Grant in Nepal. The paper draws on global evidence pointing to the vital role of parenting practices for children’s development and explains the essence of the programme used with parents in Nepal. Selected findings from impact studies carried out in 2018 and 2019 are used to show the positive changes found in parents’ behaviour with their children after participating in the sessions. It is argued that instead of merely seeing the Child Grant as a means to nutritional improvements it should be used as a pathway to advance development in all domains of early childhood – physical, cognitive, social and emotional – so that children get a good start in life. The parenting programme implemented by Save the Children as a ‘cash plus’ approach for the Child Grant holds great promise to support the ability of children to develop to their full potential.
A Low Cost and Portable Electrocardiogram (ECG) for Predicting Arrhythmia

Field: Medicine (Health Sciences)

Electrocardiogram (ECG) refers to the test performed on the heart with a view to detect abnormalities in the cardiovascular system if any. The careful analysis of the components of ECG enables the medical experts to detect the minor abnormalities of the heart and suggest effective treatment. This paper proposes an effective method of analyzing the ECG to detect the various abnormalities. After the collection and analysis of the ECG signal, behavioral and dynamic features can be obtained from the signal followed by two methods of classification by factor and feature testing. The proposed work for this paper has been implemented using MATLAB. The proposed methodology proved effective in analyzing and classifying the ECG signals with 97% accuracy.
The awakening (1984) : producing a Chinese-Singaporean identity in multiracial Singapore

Field: Arts and Humanities (Social Sciences)

This thesis studies The Awakening (1984), Singapore’s first locally produced long-running drama series, and argues that it was the government’s tool to instil a common Chinese-Singaporean identity and past to its Chinese viewers. It further contends that this carefully curated Chinese-Singaporean image was a calculated race-based strategy to overcome the domestic and global challenges of the 1980s. Lastly, this paper posits that the varied responses towards the show demonstrate that spreading pedagogical discourse through television programmes was not simply a monolithic, one-directional process. The 53-episode long and four-part Mandarin historical fiction chronologically relates Singapore’s history from the 1920s to 1984. The first instalment covers the Chinese migrant workers’ humble beginnings and struggles. The second features the Japanese Occupation. The third highlights the tumultuous years leading to Independence, while the last conveys the country’s rapid industrialisation and economic development. Singapore Broadcasting Corporation, a statutory body, created the series, and the issues portrayed in it inevitably paralleled the government’s agenda. By examining the characters, plot, scripted dialogue, and visual symbols in the drama, this thesis hopes to highlight the salient themes from the government’s Chinese-centred interpretation of Singapore’s history, and investigate their key intentions of producing such a series.
Antibacterial Effect of Distemonanthus benthamianus Extract Against Some Oral Pathogens.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Chewing sticks are widely used in Nigeria for dental and oral hygiene. In-vitro susceptibility test was done with aqueous extracts of Distemonanthus benthamianus on three test isolates (Staphylococcus aureus ATCC 8043, Saccharomyces cerevisiae ATCC 2601 and Pseudomonas aeruginosa ATCC 27853) using agar well difffusion technique. Staphylococcus aureus ATCC 8043 produced highest zone of inhibition to water extract of the plant with a value of 35.0 mm at 200 mg/ml. All organisms were susceptible to the ethanolic extract with Staphylococcus aureus ATCC 8043 and Saccharomyces cerevisiae ATCC 2601 exhibiting highest zone of inhibition with a range of 23.0-35.0 mm and 30.0-35.0 mm respectively. Phytochemical analysis of the plant revealed no significant difference in the concentration of alkaloids and saponin. Flavonoids, phenol, steroid and tanin were among the active priciples present in the plant.
Mineral Constituents Profiling of Ready-To-Drink Nutritional Supplements by Inductively Coupled Plasma Optical Emission Spectrometry

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Nutritional drinks (NDs) are medicinal food products intended for people with different health issues constricting nutrients provision. Eight varieties of milkshake style NDs were analyzed in this work. Prior to element analysis, they were freeze-dried, and concentrations of twenty macro- and microelements in analyzed samples were simultaneously measured by ICP-OES after their mineralization in a closed-vessel microwave-assisted digestion system. Results of this analysis indicated that these NDs must be considered as nutrient-dense foods, taking into account mineral constituents. Consumption of two bottles of such NDs per day provides very a high amount or even an excess of human daily requirements set as Recommended Dietary Allowances (RDAs). Generally, concentrations of determined elements in examined NDs were consistent with data given on the labels—most of differences did not exceed 30% (median: −5.91%, standard deviation: 14%). Discovered very strong and moderate positive correlations between concentrations of major and essential elements (Ca, Mg, P, Cu, Fe, Mn, Zn) were likely due to their incorporation into formulations of analyzed NDs. However, relationships between contents of trace elements were the result of concomitance of these elements in substrates used for examined products production or contamination of substrates.
Comparison of Bimatoprost and Timolol for Treatment of Chronic Angle Closure Glaucoma

Field: Medicine (Health Sciences)

Angle-closure glaucoma occurs when the normal drainage of fluid within the eye, specifically the aqueous humor, is obstructed or restricted. Objective: To assess and compare bimatoprost 0.03% administered once daily versus timolol 0.5% administered twice daily in patients diagnosed with chronic angle closure glaucoma (CACG). Methods: This randomized controlled study was performed at the Department of Ophthalmology, Bahawalpur Victoria Hospital, Bahawalpur, Pakistan, from August 2023 to January 2024. Patients of either gender, aged 18 years or older, and diagnosed with unilateral or bilateral CACG were included. Patients were randomly allocated to either Bimatoprost 0.03% (once daily at night) or Timolol malete 0.5% (two times morning and night daily) adopting a lottery method. Patients were asked to visit after one and 3 months (final outcome) and intraocular pressure (IOP) measurements were taken between 8 to 10 am using an applanation tonometer. Results: A total of 110 patients of which 64 (58.2%) were female. The mean age was 58.9 ± 10.5 years. At baseline, the mean intraocular pressure was calculated to be 24.2 ± 5.7 mmHg. After 1-month (18.7 ± 4.2 mmHg vs. 20.5 ± 4.7 mmHg, p=0.0418) and 3-months of treatment (16.8±4.6 mmHg vs. 19.6 ± 4.3 mmHg, p=0.0030), the mean IOP were significantly less in Bimatoprost group when compared to Timolol group. The commonest adverse events were conjunctival hyperaemia, and pruritus reported by 19 (17.3%), and 9 (8.2%) patients respectively. Conclusions: Bimatoprost exhibited a significantly better reduction in IOP compared to timolol in chronic angle closure glaucoma. Both drugs showed relatively good safety and tolerability profiles.
15. दलत सनम क भमक समजक परवरतन और नयय क मग

Field: Arts and Humanities (Social Sciences)

There is no end to human curiosity, cinema was invented as a result of this curiosity. Cinema first originated in western countries, later it arrived in India. Cinema, from being the main means of entertainment for humans, is now capable of openly showing social education, realism and social dynamics. Contemporary cinema has made such films by including every aspect of society, which has reflected the life struggle and problem of all people like gender equality, feminism, marginalized-Dalit, tribal. Dalit cinema has always demanded its share of justice from the society, for which they have had to struggle a lot. Not everyone can Dalits deeply and has also presented their every problem and its solution. understand the pain and rebellion of Dalits. But Dalit cinema has measured the problems of
SiC Merged PiN and Schottky (MPS) Power Diodes Electrothermal Modeling in SPICE

Field: Engineering (Physical Sciences)

This paper sets out a behavioral macro-model of a Merged PiN and Schottky (MPS) diode based on silicon carbide (SiC). This model holds good for both static and dynamic electrothermal simulations for industrial applications. Its parameters have been worked out from datasheets curves by drawing on the optimization method: Simulated Annealing (SA) for the SiC MPS diodes made available in the industry. The model also adopts the Analog Behavioral Model (ABM) of PSPICE in which it has been implemented. The thermal behavior of the devices was also taken into consideration by making use of Foster' canonical network as figured out from electro-thermal measurement provided by the manufacturer of the device.