jimnoneill/paper-to-field-training huggingface dataset:
Resistance to erythromycin and rising penicillin MIC in Streptococcus pyogenes in India.

Field: Medicine (Health Sciences)

There has been worldwide resurgence in the incidence of Streptococcus pyogenes infection and its sequelae. S. pyogenes remains uniformly susceptible to penicillin, and it is speculated that its minimum inhibitory concentration (MIC) has not changed during the past 70 years. The purpose of the present study was to determine the occurrence and pattern of resistance to penicillin and erythromycin amongst clinical isolates of S. pyogenes. A total of 34 clinical strains of S. pyogenes were identified by standard procedures. Antimicrobial susceptibility was analyzed by the Kirby-Bauer method of disk diffusion, and the E-test method was used to determine the MIC to penicillin and erythromycin. All the strains were sensitive to penicillin, clindamycin and vancomycin on disk diffusion. Ten (29.4%) strains were resistant to erythromycin. The pattern of macrolide resistance observed was M type. By the E-test method, 7 (20.6%) strains were penicillin nonsusceptible and 6 (17.6%) were erythromycin resistant. We concluded that surveillance of its susceptibility pattern is crucial to monitoring the development of antibiotic resistance in S. pyogenes.
A Novel EphA4-Based Small Molecule-Based Therapeutic Strategy for Prevention and Treatment of Post-Traumatic Osteoarthritis

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract : Post-traumatic osteoarthritis (PTOA) is a painful and debilitating disease of the joints, characterized by intra-articular inflammation, deterioration of articular cartilage, and degenerative changes to peri-articular and subchondral bone. There is currently no effective therapy. This project capitalizes our discovery that the forward signaling of EphA4 receptor has both an anti-catabolic effect (on osteoclasts/chondroclasts) and an anabolic effect (on chondrocytes) on skeletal tissues and seeks to develop a small molecule-based therapy for PTOA that involves merely direct injection of a soluble EphA4-acting EfnA-fc protein into the injured synovium. We will first confirm that EfnA-fc-mediated activation of the forward signaling of EphA4 in synoviocytes and infiltrating neutrophils/monocytes would reduce survival and the release of pro-inflammatory cytokines and MMPs, but, in articular chondrocytes, would enhance chondrogenesis in vitro. We will then optimize a small molecule EfnA-fc-based strategy involving injections of an EphA4-binding EfnA-fc into the joint by determining an appropriate EfnA-fc ligand for EphA4, an optimal dosage, and the time course of the effect, and an appropriate duration between injections. Finally, we will determine whether the small molecule EfnA-fc-based therapeutic strategy can prevent PTOA-mediated degradation of articular cartilage in early PTOA, and also can promote regeneration of articular cartilage in established PTOA. If this therapy is effective, it will improve the quality of life of PTOA patients, not only in the active duty military personnel and the veteran population, but also in the civilian population. It may even allow the warrior to return to active duty. This proposal has high military benefits.
Fast Aberration Measurement in Multi-Dimensional STEM

Field: Materials Science (Physical Sciences)

Journal Article Fast Aberration Measurement in Multi-Dimensional STEM Get access Andrew R Lupini, Andrew R Lupini Materials Science & Technology Division, Oak Ridge National Laboratory, Oak Ridge, TNInstitute for Functional Imaging of Materials, Oak Ridge National Laboratory, Oak Ridge, TN Search for other works by this author on: Oxford Academic Google Scholar Miaofang Chi, Miaofang Chi Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN Search for other works by this author on: Oxford Academic Google Scholar Sergei V Kalinin, Sergei V Kalinin Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TNInstitute for Functional Imaging of Materials, Oak Ridge National Laboratory, Oak Ridge, TN Search for other works by this author on: Oxford Academic Google Scholar Albina Y Borisevich, Albina Y Borisevich Materials Science & Technology Division, Oak Ridge National Laboratory, Oak Ridge, TNInstitute for Functional Imaging of Materials, Oak Ridge National Laboratory, Oak Ridge, TN Search for other works by this author on: Oxford Academic Google Scholar Juan Carlos Idrobo, Juan Carlos Idrobo Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN Search for other works by this author on: Oxford Academic Google Scholar Stephen Jesse Stephen Jesse Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TNInstitute for Functional Imaging of Materials, Oak Ridge National Laboratory, Oak Ridge, TN Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 22, Issue S3, 1 July 2016, Pages 252–253, https://doi.org/10.1017/S1431927616002117 Published: 25 July 2016
Prevalence of Giardia intestinalis and other zoonotic intestinal parasites in private household dogs of the Hachinohe area in Aomori prefecture, Japan in 1997, 2002 and 2007

Field: Veterinary (Health Sciences)

An epidemiological study on canine intestinal parasites was undertaken to evaluate changes in the prevalence among private household dogs from the Hachinohe region of Aomori prefecture, Japan, in 1997, 2002 and 2007, using the formalin-ethyl acetate sedimentation technique. The risk of zoonotic transmission from household dogs to humans was also discussed. All intestinal parasites detected in the present study (Giardia intestinalis, Isospora spp., Toxocara canis, Ancylostoma caninum, Trichuris vulpis and Strongyloides stercoralis) showed no changes in prevalence over the past 10 years based on analysis considering canine epidemiological profiles. In particular, prevalence of Giardia intestinalis in dogs under 1 year old, derived from pet shops/breeding kennels and kept indoors was unchanged, remaining at a high level of >15.0% at each time point. Toxocara canis also showed no changes in the group of dogs under 1 year old, bred by private owners and kept outdoors, and the prevalence was >10.0% every year. The present results indicate that the prevalence of Giardia intestinalis and other intestinal parasites in private household dogs has not always decreased, and the potential for direct parasitic zoonotic transmission from dogs to humans may be relatively high level, than from the environment (indoors and outdoors). We recommend careful surveillance of intestinal parasites and aggressive use of anthelminthic in private household dogs under considering the epidemiological factors.
Data supporting 'Optimal perturbation growth on a breaking internal gravity wave'

Field: Physics and Astronomy (Physical Sciences)

These data were generated by the simulations described in the accompanying paper, and allow the recreating of figures 3-8. The code is available at https://github.com/Jezz0r/Stratiflow/tree/triplyperiodic. Figures 1 & 2 come from data generated for Howland, Taylor & Caulfield (2021); for further details see that work.
PHILADELPHIA'S EXPERIENCE USING STATIC, NON-AERATED CURING TO PRODUCE LOW ODOR BIOSOLIDS

Field: Environmental Science (Physical Sciences)

PHILADELPHIA'S EXPERIENCE USING STATIC, NON-AERATED CURING TO PRODUCE LOW ODOR BIOSOLIDSOdors produced from biosolids have become an increasing problem and are often cited as a significant concern by many wastewater treatment plant operations. Public sensitivity to the beneficial reuse of malodorous biosolids has grown substantially and the pressure to produce a material with low odor potential has increased correspondingly. Recent research has shown that the generation of malodorous...Author(s)Ralph EschbornMatthew J. HigginsTrudy JohnstonWilliam ToffeySourceProceedings of the Water Environment FederationSubjectSession 3: OdorsDocument typeConference PaperPublisherWater Environment FederationPrint publication date Jan, 2006ISSN1938-6478SICI1938-6478(20060101)2006:2L.31;1-DOI10.2175/193864706783797195Volume / Issue2006 / 2Content sourceResiduals and Biosolids ConferenceFirst / last page(s)31 - 49Copyright2006Word count259
“Why don’t you get a job?”: the post-war system, the neoliberal system,and Australian employment policy : a thesis submitted in partial fulfilment of the requirement for the degree of Masters of Research in the Department of Modern History, Politics, and International Relations

Field: Social Sciences (Social Sciences)

This thesis provides an analysis of post-Second World War employment policy in Australia. Specific focus is paid to the post-war system (1946 to 1975) and the neoliberal system (1975 to the present), the theoretical underpinnings of these systems, and how these manifest in employment policy. The post-war system is first analysed and shown to have a positive employment record, buffered by the full employment commitment of the state. The breakdown of the post-war system during the Whitlam years, signalled by the abandonment of full employment, was driven by institutional and political forces that gained support during the 1970s crisis of stagflation. This was further entrenched by the Fraser government. The neoliberalisation of Australian employment policy during the Hawke-Keating years is then discussed, a period in which Australia underwent significant economic reform, culminating in limited jobs programs for the early 1990s recession. The Howard government further entrenched the neoliberalisation of Australian employment policy through the quasi-marketisation of employment services, and attacks on labour and unions. Finally, it is shown that the expansionary response of the Rudd government to the GFC, while providing a boost to employment, did not challenge the neoliberal system.
Long-term Mortality Outcomes of Hyperkalemic Patients in the Emergency Department Setting: A Case Control Study

Field: Medicine (Health Sciences)

Background:The impact of an episode of hyperkalemia on long term mortality is not well studied.Such a study is vital for development of a utilization strategy for new drugs for the treatment of hyperkalemia.To study the long term impact of hyperkalemia on mortality, we conducted a retrospective, observational casecontrol study in a tertiary care emergency department.We compared cases of non-hemolyzed serum potassium >5.3 mEq/L with normokalemic controls.Allcause mortality and causes of death were determined from social security death index, national death index, and medical record review over a follow-up period of 490 patient years. Methods and Findings:A total of 287 consecutive subjects (223 cases, 64 controls) were identified among 14,483 patients.Cox proportional hazard regression showed that for each 1 mEq/L increase in admit potassium, all-cause mortality Hazard Ratio was 1.54, 95% Confidence Interval: 1.22-1.96.Subgroup analyses showed higher mortality in acute kidney injury and heart failure patients. Conclusion:Hyperkalemia predicted all-cause mortality, when adjusted for age, sex, Charlson comorbidity index, and significant covariates (heart failure and end stage renal disease).The deleterious effect of admit hyperkalemia persisted in survivors from index episode throughout the study period.Cardiovascular mortality was statistically more prevalent.Future studies are needed for risk stratification strategies and mortality impact of newer drugs.
Molecular Genetics of Bipolar Disorder

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Bipolar (BP) disorder is a severe mood disorder affecting about 1% of the population. Even though the traditional twin, family, and adoption studies have demonstrated that it is highly heritable, the specific vulnerability genes have so far escaped identification. The early years of molecular genetic studies in BP disorder were hampered by the complexities in the inheritance and phenotype of BP disorder, the poor marker maps and the low informativeness of DNA markers available at that time. The new developments in molecular genetics and statistical analysis methods for complex disorders have provided researchers with better tools to cope with these difficulties. During the past few years, several potential susceptibility loci have been reported in chromosomes 18, 21 and X, and the possible role of trinucleotide repeat expansions in the aetiology of BP disorder has been developed. It seems that the molecular genetics of BP disorder are entering a new era of rapid developments.
The Influence of Cutting Edge Radius Size on the Tool Life of Cemented Carbide Drills

Field: Engineering (Physical Sciences)

The paper deals with the issue of cutting edge radius sizes their influence on the tool life of coated cemented carbide drills.Theoretical analysis was focused to the issue of cutting edge microgeometry, discussing the classification and importance of cutting edge microgeometry.The most famous and used edge preparation methods are summarized in this article.The tool lives of cemented carbide drills were compared when cutting edge radius was varied.Cemented carbide drills were deposited by TiAlN coating.Tool life tests were carried out on EMAG VSC 400 machining centre.These results were investigated in the process of machining of EN-GJL-250 grey cast iron (equivalent to DIN GG25, equivalent to ASTM A48).
Enarmonia haemograpta

Field: Agricultural and Biological Sciences (Life Sciences)

203. “ Enarmonia ” haemograpta (Meyrick, 1928) Laspeyresia haemograpta Meyrick, 1928; Exotic Microlepid. 3: 451. TL: India, Andaman Islands. Distribution: India (Andaman Islands). Illustrations: Adult and genitalia (Clarke 1958: 440).
Blood Pressure Estimation with Considering of Stroke Volume Effect

Field: Medicine (Health Sciences)

The mean arterial pressure (MAP) is a very important cardiovascular parameter for physicians to diagnose various cardiovascular diseases. Many algorithms were used to estimate MAP with different accuracy. These algorithms used different factors, such as blood level, pulses, and external applied pressure, photo-plethysmography (PPG) signal features, heart rate (HR), and other factors. In addition, some natural-based techniques were employed to minimize the difference between estimated and measured blood pressure, as well as to measure blood pressure continuously. This article presents an algorithm to estimate MAP, utilizing the HR, Stroke Volume (SV), and Total Peripheral Resistance (TPR), with considering SV changing influence; this consideration is investigated mathematically, and by the Particle Swarm Optimization (PSO) technique.Request access from your librarian to read this chapter's full text.
Diffusive motions in living cytoplasm probed by laser Doppler microscopy

Field: Agricultural and Biological Sciences (Life Sciences)

SUMMARY We have examined cytoplasmic motions in growing pollen tube tips using laser Doppler microscopy, a non‐invasive and non‐destructive technique. The observed correlation functions were consistent with the existence of diffusive motions in the tip cytoplasm. Further analysis of the data revealed the existence of at least two major and a third, minor, diffusing species in the cytoplasm. Information from quantitative electron microscopy and from published literature values of cytoplasmic viscosity was used to tentatively identify the organelles contributing to the observed diffusive motions. It is concluded that motions of mitochondria and secretory vesicles dominate the observed correlation functions with a minor component detected from either ribosomes or the microfilament network. Sources of variation in the observed data are discussed, as are the physical limitations that prevent a more positive analysis of the present data.
Carfilzomib

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Carfilzomib is a selective proteasome inhibitor used for the treatment of multiple myeloma and mantle cell lymphoma. The metabolism of carfilzomib was examined in rats after intravenous administration. Metabolites in the plasma, urine, and bile samples were analyzed. Amide hydrolysis and the opening of the epoxide were the major metabolic pathways observed, which generated numerous metabolites. In addition, hydroxylation of the isobutyl group and the dehydrogenation of the morpholine ring were the minor metabolic pathways. Morpholino‐homophenylalanine, morpholino‐homophenylalanine‐leucine, and the diol of carfilzomib were the most abundant metabolites in both plasma and excreta.
Urgensi Pembinaan Karakter Mahasiswa Fakultas Dakwah dalam Membentuk Da’i Profesional

Field: Social Sciences (Social Sciences)

Abstract. Character building is a concept that is implanted into a person and can shape a person's personality to be more polite and civilized, and, so that he will have a better character in his life. It is also important to apply to students of the da'wah faculty to print professional da'i. The author conducted a study that aims to determine the urgency, effort and character building factors in forming professional da'i students of the UNISBA da'wah faculty. The method used in this study is a qualitative method with a descriptive approach. Data collection techniques are interviews and literature study. The results of this study are that the urgency of character building is carried out to form a professional preacher who is an expert in his field. Efforts made by the da'wah faculty are formal learning in class and extracurricular learning. And the obstacle in the formation of professional preacher is that the da'wah faculty pays less attention to the da'wah rhetoric of its students. Abstrak. Pembinaan karakter merupakan sebuah konsep yang ditanamkan kedalam diri seseorang dan dapat membentuk pribadi seseorang menjadi lebih santun dan beradab, serta, sehingga akan mempunyai watak yang lebih baik dalam kehidupannya. Hal ini pun penting diterapkan kepada mahasiswa fakultas dakwah untuk mencetak da’i professional. Penulis melakukan penelitian yang bertujuan untuk Mengetahui urgensi, upaya dan faktor pembinaan karakter dalam membentuk da’i profesional mahasiwa fakutas dakwah UNISBA. Metode yang digunakan dalam penelitian ini yaitu metode kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data yaitu dengan wawancara dan studi kepustakaan. Hasil penelitian ini yaitu bahwasannya urgensi pembinaan karakter dilakukan untuk membentuk seorang da’i professional yang ahli di bidangnya. Upaya yang dilakukan oleh fakultas dakwah yaitu dengan pembelajaran formal di kelas dan pembelajaran ekstrakulikuler. Dan hambatan dalam pembentukan da’i professional yaitu fakultas dakwah kurang memperhatikan lebih kepada retorika dakwah mahasiswanya.
Role of Communication in Adaptive Mechanisms of Micro and Small Entrepreneurship for Disabled in Indonesia

Field: Social Sciences (Social Sciences)

People with disabilities face multiple challenges in entrepreneurship, including physical limitations, accessibility to resources, and social stigma that often hinders their business development. This study aims to explore the challenges and adaptive strategies faced by people with disabilities in entrepreneurship and identify critical factors that can support their business success. Focusing on the use of communication technology and financial support, this research examines how adaptive training and inclusive policies can influence the success of disabled entrepreneurs. The research methodology involves a literature review and data analysis from various sources to understand communication, adaptive mechanisms, micro and small entrepreneurship, and people with disabilities. Relevant data surrounding these variables were collected, summarized, and analyzed. This study underscores the pivotal role of communication in the adaptive mechanisms of micro and small enterprises operated by individuals with disabilities. Through an extensive literature review, it has been demonstrated that effective communication is essential for disabled entrepreneurs to establish robust social networks, engage with customers, and secure vital resources to address various business challenges.
Thermal Stability Study of a Solder-Impregnated No-Insulation HTS Coil Via a Raman-Based Distributed Optical Fiber Sensor System

Field: Engineering (Physical Sciences)

Mechanical stability of no-insulation (NI) high-temperature superconducting (HTS) coils will be greatly enhanced after using a solder impregnation (SIM) method. For superconducting high-field magnet applications, besides the mechanical stability, the thermal stability of SIM coils is also a crucial parameter which needs to be investigated. Due to its high insulation, convenient installation, distributed temperature measurement, and insensitive to stress, a Raman-based optical distributed temperature sensor (RmDTS) system is an ideal option for monitoring the temperature of SIM coils. In this study, an NI HTS coil and an optical fiber were successfully impregnated together by solder. The critical current of SIM coil determined by the central magnetic field is 69 A. To create quench process, a dc current of 240 A was injected into an SIM coil, and the temperature of the coil was monitored by the RmDTS simultaneously. The test results show that the temperature of the SIM coil was unchanged although a four times Ic was applied.
A label‐free ratiometric method to detect Hg2+ based on structural change of DNA

Field: Chemistry (Physical Sciences)

Abstract In this work, a simple ratiometric method has been designed to detect Hg 2+ based on the structural change between double‐stranded DNA (dsDNA) and its G‐quadruplex structure. When Hg 2+ was added, the designed G‐quadruplex structure could change into the corresponding dsDNA by forming the T–Hg 2+ –T mismatch. This kind of variation resulted in a decrease in the fluorescence of the G‐quadruplex/ N ‐methyl mesoporphyrin IX (NMM) complex and an increase in the fluorescence from the dsDNA/SYBR Green I (SG I) pair. The secondary excitation wavelength of SG I was used to excite NMM and SG I simultaneously. The titration experiment indicated that the new method had a linear response within 0.7–2.5 μM Hg 2+ with a limit of detection of 9.3 nM. Because using the T–Hg 2+ –T mismatch to recognize Hg 2+ was very specific, the selectivity of the new method was also satisfactory. The recoveries ranged from 92.8% to 110.2% suggested that this new method could achieve a potential application for Hg 2+ detection in real environmental samples.
Investigation of Hexavalent Chromium Flux to Groundwater at the 100-C-7:1 Excavation Site

Field: Environmental Science (Physical Sciences)

Deep excavation of soil has been conducted at the 100-C-7 and 100-C-7:1 waste sites within the 100-BC Operable Unit at the Department of Energy (DOE) Hanford Site to remove hexavalent chromium (Cr(VI)) contamination with the excavations reaching to near the water table. Soil sampling showed that Cr(VI) contamination was still present at the bottom of the 100-C-7:1 excavation. In addition, Cr(VI) concentrations in a downgradient monitoring well have shown a transient spike of increased Cr(VI) concentration following initiation of excavation. Potentially, the increased Cr(VI) concentrations in the downgradient monitoring well are due to Cr(VI) from the excavation site. However, data were needed to evaluate this possibility and to quantify the overall impact of the 100-C-7:1 excavation site on groundwater. Data collected from a network of aquifer tubes installed across the floor of the 100-C-7:1 excavation and from temporary wells installed at the bottom of the entrance ramp to the excavation were used to evaluate Cr(VI) releases into the aquifer and to estimate local-scale hydraulic properties and groundwater flow velocity.