jimnoneill/paper-to-field-training huggingface dataset:
Effect of nonspecific immune stimulation with BCG and polidin on the Ehrlich ascites tumor growth.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Investigations were performed to study: 1) the antitumor effect of BCG pretreatment on the development of Ehrlich ascites tumor in mice; 2) the effect of BCG administration in relation to the period of time before tumor inoculation and the dose levels used, and 3) the antitumor effect of an associated pretreatment of BCG and Polidin on the development of Ehrlich ascites tumor. BCG administered prior to Ehrlich ascites tumor inoculation have a protective effect evidenced by a delay in tumor development, a prolonged survival of the tumor host and, in some cases, even inhibition of tumor growth. The effect of BCG was highly dependent on 1) the dose and the time of administration of BCG and) 2 the combined pretreatment of BCG and Polidin.
Apps for Hearing Science and Care

Field: Health Professions (Health Sciences)

Purpose Our research aims at the identification and assessment of applications (referred to as apps ) in the hearing health care domain. This research forum article presents an overview of the current availability, affordability, and variety of hearing-related apps. Method The available apps were reviewed by searching on the leading platforms (iOS, Android, Windows Phone stores) using the keywords hearing, audiology, audio, auditory, speech, language, tinnitus, hearing loss, hearing aid, hearing system, cochlear implant, implantable device, auditory training, hearing rehabilitation, and assistive technology/tool/device. On the basis of the offered services, apps were classified into 4 application domains: (a) screening and assessment, (b) intervention and rehabilitation, (c) education and information, and (d) assistive tools. Conclusions A large variety of apps are available in the hearing health care domain. These cover a wide range of services for people with hearing or communication problems as well as for hearing professionals, families, or informal caregivers. This evolution can potentially bring along considerable advantages and improved outcomes in the field of hearing health care. Nevertheless, potential risks and threats (e.g., safety, quality, effectiveness, privacy, and regulation) should not be overlooked. Significant research—particularly in terms of assessment and guidance—is still needed for the informed, aware, and safe adoption of hearing-related apps by patients and professionals.
Gloria Anzaldúa’s Borderless Theory in Spain

Field: Arts and Humanities (Social Sciences)

The essay offers a brief review of the impact of Gloria Anzaldúa’s thought—in particular, of Borderlands/La Frontera—on Spanish scholarship. While the influence of this work is widespread in the scholarship produced in English literature departments in Spain, it also has an important hold in translation studies, geography, and Spanish language and literature studies. Most significantly, Anzaldúa’s borderless feminist thought is incorporated in translation in a volume on third-world feminist thinkers edited by a Spanish grassroots feminist collective in order to point toward the ways in which “white” Spanish feminist discourse and practices need to change in an increasingly intercultural, interracial country.
Searches for resonant and non-resonant new phenomena in CMS

Field: Physics and Astronomy (Physical Sciences)

Searches for resonant and non-resonant phenomena from the CMS experiment are presented. In the first part of this proceeding, the CMS legacy Run1 results are detailed. It includes searches for new physics in the following final states: dijets and multijets, dileptons (ee, μμ,ττ), diphotons, as well as leptons + missing transverse energy (MET) topologies. In the second part, preliminary results of the analysis of the CMS Run2 dataset at 13 TeV are reported.
Understanding highly excited states via parametric variations

Field: Physics and Astronomy (Physical Sciences)

Highly excited vibrational states of an isolated molecule encode the vibrational energy flow pathways in the molecule. Recent studies have had spectacular success in understanding the nature of the excited states mainly due to the extensive studies of the classical phase space structures and their bifurcations. Such detailed classical-quantum correspondence studies are presently limited to two- or quasi-two-dimensional systems. One of the main reasons for such a constraint has to do with the problem of visualization of relevant objects like surface of sections and Wigner or Husimi distributions associated with an eigenstate. This necessitates various alternative techniques which are more algebraic than geometric in nature. In this work we introduce one such method based on parametric variation of the eigenvalues of a Hamiltonian. It is shown that the level velocities are correlated with the phase space nature of the corresponding eigenstates. A semiclassical expression for the level velocities of a single resonance Hamiltonian is derived which provides theoretical support for the correlation. We use the level velocities to dynamically assign the highly excited states of a model spectroscopic Hamiltonian in the mixed phase space regime. The effect of bifurcations on the level velocities is briefly discussed using a recently proposed spectroscopic Hamiltonian for the HCP molecule.
Design, Synthesis, Characterization and AntiproliferativeActivities of Ru(II) Complexes of Substituted Benzimidazoles

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Synthesis of [Ru(PPh3)2(BZM)2Cl2] (BZM= LS1, LS2, LS3, LS4 and LS5) where LS1=(1H-benzo[d] imidazole-2-yl)methanethiol, LS2 = 2-(4-bromobutyl)-1H-benzo[d] imidazole, LS3= 2-(4-nitrophenyl)-1H-benzo[d]imidazole, LS4 = 2-(4-chlorophenyl)-1H-benzo[d]imidazole and LS5= 4-(1H-benzo[d]imidazol-2-yl)aniline (BZM = benzimidazoles, PPh3 = triphenylphosphine) and metal complexes as MR, [ Ru (PPh3)4Cl2], MLS1, MLS2, MLS3, MLS4 and MLS5 for use as potential anticancer compounds have been investigated. The complexes have been characterized by elemental analysis, IR, multinuclear NMR, UV-visible and ESI-MS spectroscopic techniques. The geometries of all complexes have been optimized by using density functional theory (DFT). The cytotoxicity effects of MR, MLS2 and LS1 were also investigated on Human cervical carcinoma cells (HeLa) by MTT assay, ROS generation and nuclear apoptosis assay. The percent cell viability assessed by MTT assay suggested that the synthesized MR, MLS2 and LS1 significantly reduce the viability of HeLa cells, in a dose-dependent manner. The inhibitory concentration (IC50) of MR, MLS2 and LS1 against HeLa cells was found 90.8, 81.8 and 115 μM, respectively. These compounds also induced the over production of intracellular reactive oxygen species (ROS) as well as the condensed and fragmented nucleus, which supports the molecular mechanism of cell death by apoptosis. The investigations suggested that the compounds MR, MLS2 and LS1 induce the cell death in HeLa cells through apoptotic pathway.
Figure S1 from Vaccination with Designed Neopeptides Induces Intratumoral, Cross-reactive CD4<sup>+</sup> T-cell Responses in Glioblastoma

Field: Medicine (Health Sciences)

<p>Schematic outline of the personalized peptide vaccination. (A) Timeline of clinical events for a patient with glioblastoma in whom we applied a highly personalized peptide vaccination. I. Vaccine peptide design. Surgically resected primary glioblastoma and PBMCs were collected. Somatic mutants and over-/highly expressed genes in glioblastoma were identified as TSAs and TAAs by WES and RNA-seq, and the HLA genotype were identified with PBMCs by DNA sequencing. Potential vaccine peptides were predicted and selected from TSAs and TAAs based on HLA binding prediction. Peptide cocktails containing ~25 peptides for HLA class I or II molecules were prepared for vaccination. II. Peptide cocktail vaccination and testing. The patient was s.c. vaccinated with the peptide cocktails, and Imiquimod or XS15 + MontanideTM were used as the adjuvant. Meanwhile, the patient received treatment with pembrolizumab and bevacizumab. No dexamethasone was given throughout the periods of vaccination. PBMCs were collected after vaccination at the indicated time points and tested with vaccine peptides to examine the effect of immunotherapy. Surgically resected recurrent glioblastoma was collected after four vaccinations, and tumor-infiltrating lymphocytes (TILs) were isolated and tested with vaccine peptides. (B) HLA genotypes of the patient with glioblastoma, including HLA-A, HLA-B, HLA-DR, HLA-DP, and HLA-DQ alleles. n.a. indicates not available.</p>
RISK FACTORS AND IMPORTANCE TO CLINICAL OUTCOME OF SWALLOWING DYSFUNCTION AFTER CARDIAC SURGERY

Field: Medicine (Health Sciences)

Hogue, C W Jr. M.D.; Lappas, G D B.S.; Creswell, L L M.D.; Ferguson, T B M.D.; Sample, M M.D.; Cox, J L M.D.; Lappas, D G M.D. Author Information
Penggunaan Terasi Dedak terhadap Performa dan Berat Organ Dalam pada Ayam Broiler

Field: Agricultural and Biological Sciences (Life Sciences)

This study aims to evaluate the use of shrimp paste fermented rice bran (terasi dedak) on broilers' performance and internal organ weight. One hundred and sixty broilers were grouped into five treatments. The five treatment groups were P1= ration without terasi dedak (control), P2= ration with 5% terasi dedak, P3= ration with 10% terasi dedak, P4= ration with 15% terasi dedak, P5= ration with 20% terasi dedak. The use of terasi dedak had no significant effect on feed intake, body weight gain, feed conversion ratio, liver, gizzard, intestine, heart and cecum weights. So, terasi dedak could be used up to 20% in broiler chickens. Key words: Shrimp Paste Fermented Rice Bran, Performance, Internal Organs, Broiler ABSTRAK Penelitian ini bertujuan untuk mengevaluasi penggunaan terasi dedak terhadap performa dan berat organ dalam broiler. Seratus enam puluh broiler dikelompokkan ke dalam 5 perlakuan. Kelima kelompok perlakuan tersebut adalah P1= ransum 0% tanpa terasi dedak (kontrol), P2= ransum dengan 5% terasi dedak, P3= ransum dengan 10% terasi dedak, P4= ransum dengan 15% terasi dedak, P5= ransum dengan 20% terasi dedak. Penggunaan terasi dedak berpengaruh tidak nyata terhadap konsumsi pakan, pertambahan berat badan, konversi pakan, berat hati, gizzard, usus, jantung dan sekum. Jadi, terasi dedak dapat digunakan sampai dengan 20% pada ayam broiler. Kata kunci: Terasi Dedak, Performa, Organ Dalam, Broiler
Study on Winall Hi-tech Seed Co.,Ltd.'s Varieties with Light Brown Glume Marker

Field: Agricultural and Biological Sciences (Life Sciences)

Anhui Winall Hi-tech Seed Co.,Ltd.is a high-tech enterprise of seed industry integrated with crop seed research,production,processing,domestic and international trade.In 2003,Anhui Winall Agricultural Hi-tech Research Institute made a declaration of Method of breeding parent and breed of hybrid rice with recessive label,approved by the State Intellectual Property Office(SIPO) for patent protection.This invention refers to a breeding method of hybrid rice with recessive mark,introducing,collecting and physically mutagenizing the resource of rice variety whose husk color has color mark,after planting and identifying by man-made hybridization the character of husk color's hereditary,making hybridization,backcross transfer-cultivation,cultivation identification,etc.with the parents of the hybrid rice to select out the parent with recessive-mark husk color,then making combination and confirmation of effectively,and finally obtaining the parent with the recessive mark and the variety.Rapid,simple,intuitive and accurate identification for the truth of hybrid rice seed,and help to achieve color selection in mechanization of mixed planting breeding,so as to improve the quality of seed production and lower the cost.In 2005,Winall company selected and bred the first parent of bilineal hybrid rice with recessive glume color markers named Xin'an S,which owned obvious advantages including low initiative temperature of infertility,long duration of sterility,fine quality of grain,strong combining ability and high multipliability.In particular,its glume color was provided with light brown marker traits controlled by recessive genes.So the hybrid seeds were readily identifiable,which was conducive to the purity test of seeds in the F1 progeny.Taking Xin'an S as female parent,Winall Company crossed and selected multiple combinations with light brown glume anti-fake markers,such as Xinliangyou 4,Xinliangyou 6,Xinliangyou 901,Xinliangyou 343,Xinliangyou 106,etc.These varieties have been validated through national or provincial approval.Xinliangyou No.6 was the first new variety of anti-fake rice cultivated by Winall Company.Owing to the fine quality,high yield and strong ability of pest and disease resistance,the variety cultivation was widely promoted with high production in China.In 2006,Xinliangyou No.6 was certified by Ministry of Agriculture as the first lot recommended super hybrid,and later the company bred a batch of new varieties different from the former.These varieties was prominent in commodity property,which had characteristics of high yield and high quality,showing extensive adaptability,or strong lodging resistance,or excellent flavor and scent,or large grain form.So the product diversification with Xinliangyou 6 as the core and favorable supplement of other varieties took shape,which was adapted to the needs of distinct growing environments and satisfied the different demands of farmers.
Radiative Properties of MoO3 and Al Nanopowders From Light-Scattering Measurements

Field: Physics and Astronomy (Physical Sciences)

The combustion behavior of nanometer-scale energetic materials is much different than micron size or larger materials. Burning rates up to 950 m∕s have been reported for a thermite composition of nanosized aluminum and molybdenum trioxide. The energy transport mechanisms in the reactive wave are still uncertain. The relative contribution of radiation has not yet been quantified. To do so analytically requires dependent scattering theory, which has not yet been fully developed. Radiative properties for nanoaluminum and nanomolybdenum-trioxide were obtained experimentally by comparing light scattering measurements on a one-dimensional slab of powder with multiple-scattering simulations using Monte Carlo and discrete ordinate methods. The equivalent isotropic-scattering extinction coefficient for close-packed molybdenum trioxide (MoO3) nanopowder was found to be 5900±450cm−1; the equivalent isotropic-scattering albedo was 0.97±0.035. Aluminum (Al), which proved to be more difficult to work with, had an albedo of 0.35 and 0.38 from two tests. The radiative conductivity based on the MoO3 results is two orders of magnitude less than the diffusive thermal conductivity, indicating that radiation is not a dominant heat transfer mode for the reactive wave propagation of nanothermites under optically thick conditions.
New anion-exchange polymers for improved separations

Field: Chemical Engineering (Physical Sciences)

Objective is to improve the understanding of how the structure of a new class of anion-exchange polymers controls the binding of anionic actinide complexes from solution. This is needed to develop practical separation systems that will reduce the cost of actinide processing operations within the DOE complex. In addition anion exchange is widely used in industry. Several new series of bifunctional anion- exchange polymers have been designed, synthesized, and tested for removing Pu(IV), Am(III), and U(VI) from nitric acid. The polymers contain a pyridinium site derived from the host poly(4-vinylpyridine) and a second cationic site attached through a chain of 2 to 6 methylene groups. The new polymers removed Pu four to ten times more efficiently than the best commercial materials.
The characterization of some cyclic groups by the product of element orders

Field: Mathematics (Physical Sciences)

Let [Formula: see text] be a finite group. We denote by [Formula: see text] the integer [Formula: see text] where [Formula: see text] denotes the order of [Formula: see text]. It is verified that some finite groups are uniquely determined by their orders and their product of element orders. In this paper, we prove that, if [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text] are different prime numbers, then [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text] are characterized by [Formula: see text] and if [Formula: see text], then [Formula: see text] or [Formula: see text].
Table_1_Functional Characterization of an Amaranth Natterin-4-Like-1 Gene in Arabidopsis thaliana.docx

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>The functional characterization of an Amaranthus hypochondriacus Natterin-4-Like-1 gene (AhN4L-1) coding for an unknown function protein characterized by the presence of an aerolysin-like pore-forming domain in addition to two amaranthin-like agglutinin domains is herewith described. Natterin and nattering-like proteins have been amply described in the animal kingdom. However, the role of nattering-like proteins in plants is practically unknown. The results described in this study, obtained from gene expression data in grain amaranth and from AhN4L-1-overexpressing Arabidopsis thaliana plants indicated that this gene was strongly induced by several biotic and abiotic conditions in grain amaranth, whereas data obtained from the overexpressing Arabidopsis plants further supported the defensive function of this gene, mostly against bacterial and fungal plant pathogens. GUS and GFP AhN4L-1 localization in roots tips, leaf stomata, stamens and pistils also suggested a defensive function in these organs, although its participation in flowering processes, such as self-incompatibility and abscission, is also possible. However, contrary to expectations, the overexpression of this gene negatively affected the vegetative and reproductive growth of the transgenic plants, which also showed no increased tolerance to salinity and water-deficit stress. The latter despite the maintenance of significantly higher chlorophyll levels and photosynthetic parameters under intense salinity stress. These results are discussed in the context of the physiological roles known to be played by related lectins and AB proteins in plants.</p>
Methylation Patterns of Cancer-Associated Genes in Breast Cancer

Field: Medicine (Health Sciences)

%), respectively. In malignant tumors, the h-MLH and RASSF1 genes were most infrequently and frequently methylated genes, respectively. The subgroup showing methylation of the DAPK gene had a higher nuclear grade and greater progesterone receptor negativity. The group in which the RASSF1 gene was methylated, had greater estrogen receptor (ER) and progesterone receptor (PgR) positivities. The Twist gene was frequently methylated in the subgroup showing higher nuclear and histologic grades. The group with HIN1 and cyclin D methylation had a tendency to show greater ER positivity. Conclusion: The subgroups showing methylated DAPK and Twist should be more intensely treated and followed up more carefully than those with RASSF1 , HIN-1 and Cyclin D methylation. Gene methylation may be linked to various pathological features of breast cancer; however, this will require confirmation from larger studies. (J Breast Cancer 2007;10:51-8)
ANISOTROPY OF THE ELECTRON-DOPED INFINITE-LAYER SUPERCONDUCTOR Sr0.9La0.1CuO2

Field: Physics and Astronomy (Physical Sciences)

Anisotropy of a c-axis aligned Sr 0.9 La 0.1 CuO 2 infinite-layer superconductor was studied by measuring the magnetization in different temperature (M(T)) and angle (M(θ)). The M(θ) and the critical temperature as a function of the angle (T c2 (θ)) deduced from M(T) was well described by the anisotropic Ginzburg-Landua theory with a moderate anisotropy value γ≈9. This low value, which is comparable to that of YBa 2 Cu 3 O 7-δ implied strong interlayer coupling between CuO 2 planes. In this compound, the strong interlayer coupling was thought to solely result from the crystal structure without charge reservoir blocks.
Metronidazole induces programmed cell death in the protozoan parasite Blastocystis hominis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Previous studies by the authors have shown that the protozoan parasite Blastocystis hominis succumbed to a cytotoxic monoclonal antibody with a number of cellular and biochemical features characteristic of apoptosis in higher eukaryotes. The present study reports that apoptosis-like features are also observed in growing cultures of axenic B. hominis upon exposure to metronidazole, a drug commonly used for the treatment of blastocystosis. Upon treatment with the drug, B. hominis cells displayed key morphological and biochemical features of programmed cell death (PCD), viz. nuclear condensation and nicked DNA in nucleus, reduced cytoplasmic volume, externalization of phosphatidylserine and maintenance of plasma membrane integrity with increasing permeability. This present study also supports the authors' previously postulated novel function for the B. hominis central vacuole in PCD; it acts as a repository where apoptotic bodies are stored before being released into the extracellular space. The implications and possible roles of PCD in B. hominis are discussed.
Mental Health Nursing Student’s Perception of Clinical Simulation about Patients at Risk of Suicide: A Qualitative Study

Field: Nursing (Health Sciences)

Suicide is a serious public health problem, with a global mortality rate of 1.4% of all deaths worldwide and the leading cause of unnatural death in Spain. Clinical simulation has proven to be a beneficial tool in training nursing students. Such experiences allow them to develop cognitive and affective skills that are fundamental for the detection of warning signs and the use of interventions in cases of people who want to take their own lives. Working in a mental health environment can be difficult for nursing students; therefore, the purpose of this study was to explore the perceptions of nursing students on the approach, management, and intervention of suicidal crisis through clinical mental health simulation. Methods: qualitative descriptive phenomenological study through focus groups and reflective narratives in a sample of 45 students. A thematic analysis was performed using ATLAS-ti. Results: After the analysis, three themes were obtained: (a) management and handling of emotions, (b) identification of suicide motives, and (c) intervention in suicidal crisis. Discussion: Clinical simulation in mental health allows students to exercise clinical judgment reasoning, detect warning signs for a better treatment approach, and provide tools for effective intervention and management of patient care. The results of this study indicate that nursing students face challenges in approaching mental health clinical simulation due to a lack of prior exposure.
Total RNA Extraction from Saccharomyces cerevisiae Using Hot Acid Phenol

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Isolation of RNA from yeast is complicated by the need to first break the thick, rigid cell wall. The protocol provided here uses a cycle of heating and freezing of cells in the presence of phenol and the detergent sodium dodecyl sulfate (SDS). The extraction is performed in the presence of low salt so that, following separation of the aqueous and phenol phases by centrifugation, DNA can be collected from the interface while RNA remains in the aqueous phase. This protocol should yield ∼50–250 µg of RNA from 10 mL of culture. The RNA isolated using this approach is suitable for most follow-up applications such as northern blot hybridization, reverse transcriptase-polymerase chain reaction (RT-PCR), and cDNA construction.