jimnoneill/paper-to-field-training huggingface dataset:
Achieving High Availability and Performance in Financial Transaction Processing

Field: Computer Science (Physical Sciences)

In modern financial systems, ensuring both high availability and optimal performance in transaction processing is critical for maintaining operational efficiency and client trust. The growing demand for real-time transactions and the increasing complexity of financial services necessitate architectures that can handle large volumes of concurrent transactions while minimizing downtime. This paper explores strategies and technologies used to achieve high availability and performance in financial transaction processing systems. We delve into the design of fault-tolerant and highly available architectures, highlighting the role of distributed systems, load balancing, and database replication. Additionally, we discuss performance optimization techniques, including caching, indexing, and asynchronous processing, which are crucial for reducing latency and enhancing throughput. The integration of cloud computing, serverless architectures, and containerization is also considered for their potential to scale financial systems dynamically while maintaining service continuity. Key challenges, such as handling transaction failures, managing concurrency, and ensuring data consistency, are examined alongside best practices for mitigating risks associated with these issues. The paper concludes with a discussion of emerging trends, including machine learning for predictive failure detection and the adoption of blockchain for enhancing security and transparency. By implementing a combination of these strategies, financial institutions can build resilient and efficient transaction processing systems capable of meeting the ever-growing demands of the global financial market.
Interleaved Acoustic Environments: Impact of an Auditory Scene Classification Procedure on Speech Perception in Cochlear Implant Users

Field: Medicine (Health Sciences)

Clinical speech perception tests with simple presentation conditions often overestimate the impact of signal preprocessing on speech perception in complex listening environments. A new procedure was developed to assess speech perception in interleaved acoustic environments of different complexity that allows investigation of the impact of an automatic scene classification (ASC) algorithm on speech perception. The procedure was applied in cohorts of normal hearing (NH) controls and uni- and bilateral cochlear implant (CI) users. Speech reception thresholds (SRTs) were measured by means of a matrix sentence test in five acoustic environments that included different noise conditions (amplitude modulated and continuous), two spatial configurations, and reverberation. The acoustic environments were encapsulated in a randomized, mixed order single experimental run. Acoustic room simulation was played back with a loudspeaker auralization setup with 128 loudspeakers. 18 NH, 16 unilateral, and 16 bilateral CI users participated. SRTs were evaluated for each individual acoustic environment and as mean-SRT. Mean-SRTs improved by 2.4 dB signal-to-noise ratio for unilateral and 1.3 dB signal-to-noise ratio for bilateral CI users with activated ASC. Without ASC, the mean-SRT of bilateral CI users was 3.7 dB better than the SRT of unilateral CI users. The mean-SRT indicated significant differences, with NH group performing best and unilateral CI users performing worse with a difference of up to 13 dB compared to NH. The proposed speech test procedure successfully demonstrated that speech perception and benefit with ASC depend on the acoustic environment.
Passive Membrane Penetration of the Serotonin Precursor 5‐Hydroxytryptophan is Controlled by Its Zwitterion

Field: Chemistry (Physical Sciences)

Species‐specific partition coefficients in the octanol/water system were determined for the neurotransmitter serotonin (5‐ HT ) and its precursor 5‐hydroxytryptophan (5‐ HTP ). The pH ‐independent partition coefficients ( p ) of the individual microspecies were determined by combination of experimentally measured distribution constants and a custom‐tailored evaluation method, using highly similar auxiliary compounds. Experimental microscopic partition coefficients for triprotic molecules have only been reported before for thyroxine and its derivatives. The parabolic pH ‐distribution profile of 5‐ HT shows the dominance of the lipophilic non‐charged microspecies, with a log p of 0.66. However, the most lipophilic non‐charged form of 5‐ HTP , with a log p of 0.31, has no significant contribution to the distribution coefficient at any pH value. Instead, the less lipophilic zwitterionic protonation isomer dominates the distribution in the pH range 2.10 – 11.11. Although the non‐charged microspecies of 5‐ HTP is 151 times more lipophilic than its zwitterionic protonation isomer, the overwhelming dominance of the zwitterionic form ensures that its contribution to the overall lipophilicity exceeds 1320 times that of the non‐charged one. This fact is another counter‐example of the widespread belief that passive diffusion into lipophilic media is predominated by the non‐charged species. The lipophilicity profile of 5‐ HT and 5‐ HTP is depicted in terms of species‐specific lipophilicities.
Research on Fipronil for Termite Control in Building Construction

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Objective:To screen an ideal insecticide for control of termites in building construction. Methods: Toxicity test, capability of transferring toxicity test, analogous field test et al. Results: Fipronil 100 ppm concentration was effective in termite control. Conclusion: Fipronil has good killing activity and strong toxicity against termites and can replace other insecticides to control termites.
Clinical Features and Multimodal Imaging in Atypical Posterior Uveitis Secondary to Bartonella Henselae Infection

Field: Medicine (Health Sciences)

Ocular manifestations of Bartonella henselae infection are varied and may include choroidal granulomas. Multimodal imaging characteristics may help identify etiologies of infectious uveitis. Convalescent titers are important when evaluating patients with suspected Bartonellosis, especially patients with atypical presentations.
Prevention, Detection and Management of Oral Cancer

Field: Dentistry (Health Sciences)

Up to 70% of oral cancers are preceded by premalignant oral lesions, such as persistent red or white patches in the mouth. Survival rates for oral cancer can be improved through early detection. It is therefore essential that oral health professionals such as dentists, dental hygienists, dental therapists, and oral health therapists understand the importance of conducting a thorough oral screening examination for malignant and potentially malignant lesions as part of their routine clinical assessments, even in younger populations considered at lower risk for oral cancer. Key features of the book include: laser treatment techniques ,human genome sequencing, early detection and multidisciplinary approach ,management strategies and mechanisms of proliferation and energy metabolism in oral cancer.
Research Report of SC12 Model Working Machine in Mulberry Fields

Field: Agricultural and Biological Sciences (Life Sciences)

Diesel engine with 8 8 kW,walking machine and vertical,horizntal power output equipment are made up drawing locomotive,and according to work period,a multi-functional machine in mulberry fields in plowing,spraying insecticide liquids,transportation was assembled by puting together with rotary tillage device,post fill pump,excrement pot,or tow case.This machine was tested in production and showed characters such as plowing depth 0 15 m,plowing width 0 6 m,working efficiency 0 115 2～0 156 hm2/h in rotary tillage device,the coverage rage of vegetation 50%～60%,self-loading 1 000 L insecticide liquids,filling liquids with the horizontal power output shaft to transmit column cork pump,and with the cooperation of the spraying gun,spraying distance 10～12 m,the amount of spraying insecticide liquid 2 879-4 111 L/hm2,work efficiency 0 467-0 667 hm2/h.The depth of sucking excrement liquid of excerment pot is 5 m,sucking 1 000 L excrement liquid only for 5 min,unloading excrement liquid for 2 min.The loading capacity of the tow case is 1 t,and the transportation speed is 12 km/h.
An Active Power Decoupling Method for Single Phase DC/AC DAB Converters

Field: Engineering (Physical Sciences)

The existence of the double grid frequency (100 Hz) ripple current in dc/ac dual active bridge (DAB) power converters can degrade their performance and as such these ripples need to be compensated. An active power decoupling method is proposed in this paper to attenuate the 100-Hz current ripple in single phase dc/ac DAB converters. Compared to other current ripple reduction methods for which additional switches are used, the proposed method does not require any additional switching components thus decreasing the system cost. In the proposed method, the existing switching devices of the primary side full bridge converter and an LLC circuit integrated to form a 100-Hz ripple current reduction circuit, which is controlled by regulating the duty cycle of the primary full bridge converter switching legs. The mathematical analysis and the circuit parameter design methods are proposed. In addition, a current sharing method is proposed to keep the currents of the inductors in the LLC circuit are balanced against any possible circuit parameter deviations. The effectiveness of the developed method is evaluated through the simulation and experimental tests.
An Analysis of the Internal Migration of Indigenous and Non-indigenous Australians

Field: Social Sciences (Social Sciences)

Enhancing migration and mobility has been put forward by various commentators as a solution to Indigenous disadvantage in Australia, This paper examined patterns of migration and factors associated with the decision to move and the choice of destination in order to assess the feasibility of this suggestion. The results suggest that Indigenous Australians are less responsive to local economic factors than other Australians, with social and cultural factors appearing to play a particularly significant role in their decision making. It is probable that this reflects a ‘rational’ response to the depressed demand for Indigenous labour across Australia and the greater opportunity for non-market activities.
Variations in HDL-carried miR-223 and miR-135a concentrations after consumption of dietary trans fat are associated with changes in blood lipid and inflammatory markers in healthy men - an exploratory study

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

A high consumption of trans fatty acids (TFAs) is associated with an increased risk of cardiovascular diseases (CVDs). High-density lipoproteins (HDLs) have many cardioprotective properties and transport functional microRNAs (miRNAs) to recipient cells. We hypothesized that dietary TFAs modify the HDL-carried miRNA profile, therefore modulating its cardioprotective properties. We assessed whether consumption of dietary TFAs modifies HDL-carried miR-223-3p and miR-135a-3p concentration and the inter-relationship between diet-induced changes in HDL-carried miRNA concentration and CVD risk markers. In a double blind, randomized, crossover, controlled study, 9 men were fed each of 3 experimental isoenergetic diets: 1) High in industrial TFA (iTFA; 3.7% energy); 2) High in TFA from ruminants (rTFA; 3.7% energy); 3) Low in TFA (control; 0.8% energy) for 4 weeks each. HDLs were isolated by ultracentrifugation and miRNAs were quantified by RT-qPCR. Variations in HDL-miR-223-3p concentration were negatively correlated with variations in HDL-cholesterol after the iTFA diet (rs = 0.82; P = 0.007), and positively correlated with variations in C-reactive protein concentration after the rTFA diet (rs = 0.75; P = 0.020). Variations in HDL-miR-135a-3p concentration were positively correlated with variations in total triglyceride (TG) concentration following the iTFA diet (rs = -0.82; P = 0.007), and with variations in low-density lipoprotein (LDL)-TG concentration following the rTFA diet (rs = 0.83; P = 0.005), compared to the control diet. However, the consumption of dietary TFAs has no significant unidirectional impact on HDL-carried miR-223-3p and miR-135a-3p concentrations. Our results suggest that the variability in the HDL-carried miRNAs response to TFA intake, by being associated with variations in CVD risk factors, might reflect physiological changes in HDL functions.
IMMU-33. REPROGRAMMING OF MYELOID CELL METABOLISM VIA HEME OXYGENASE-1 INHIBITION POTENTIATES ANTI-TUMOR IMMUNITY IN A MURINE GLIOMA MODEL

Field: Medicine (Health Sciences)

Abstract Cancer cells exhibit a preference for aerobic glycolysis, a phenomenon known as the Warburg effect. Emerging evidence suggests that immune cells within the tumor microenvironment (TME) may employ a similar metabolic adaptation. Heme oxygenase-1 (HMOX-1), a metabolic regulatory gene, is elevated in myeloid cells of glioblastoma (GBM), yet its precise role in modulating immune suppression and energy utilization remains unclear. Our objective was to explore how targeting HMOX-1 activity in the GBM TME affects immune response and energy metabolism. We utilized syngeneic glioma models with C57BL/6J mice implanted with CT-2A cells, which were randomized into four treatment arms: intracranial (IC) injection of the HMOX-1 inhibitor zinc protoporphyrin (ZnPP), intraperitoneal (IP) injection of anti-PD-1, IC ZnPP + IP anti-PD-1, or IC saline (sham). For mechanistic studies, we developed a myeloid-specific knockdown model via adoptive cell transfer of myeloid-derived suppressor cells (MDSCs) transfected with Hmox-1 siRNA into CSF-1R myeloid-depleted mice. Immunophenotyping was conducted with flow cytometry. The Seahorse mitochondrial stress test was used for evaluation of energy dynamics. Downregulation of myeloid Hmox-1 expression and inhibition of HMOX-1 via ZnPP both led to heightened T cell activation, with increased IFN-γ expression in brain compared to untreated mice (P=0.039, 0.02, respectively). Notably, ZnPP treatment induced a compensatory elevation of PD-L1 in myeloid cells (P&lt;0.0001). Both ZnPP monotherapy and anti-PD-1 + ZnPP combination therapy demonstrated enhanced median overall survival rates in comparison to sham and anti-PD-1 monotherapy groups, with the combined approach yielding the most significant survival advantage (P&lt;0.0001). Metabolic analyses following Hmox-1 knockdown and ZnPP treatment revealed a shift away from cancer-like glycolytic shunting in MDSCs. Inhibiting the HMOX-1 pathway facilitated T cell activation and reversal of glycolysis-predominant metabolism in MDSCs, resulting in improved survival outcomes in a murine glioma model. Modulation of metabolic reprogramming in myeloid cells may potentiate anti-tumor immunity, especially in conjunction with checkpoint blockade.
Correlation Functions in the Spin-fermion Model

Field: Physics and Astronomy (Physical Sciences)

We show that the quasiparticle states found in a self-consistent Born approximation for the spin-fermion modeł which describes CuO2 planes agree well with experimental data in insulating Sr 2 CuO 2 Cl2 .It is found that the antiferromagnetic correlations are reduced in the neighbourhood of a moving oxygen hole and the correlation functions can exhibit similar dipolar distortions as reported in the context of the t-J model.
Association of physical activity level with depression, anxiety, and quality of life in children with type 1 diabetes mellitus

Field: Medicine (Health Sciences)

Abstract Children with type 1 diabetes mellitus (T1DM) have low physical activity levels and are at high risk for psychosocial morbidities, including depression, heightened anxiety and low health-related quality of life (HRQoL). The aim of this study was to assess the associations of physical activity level with depression, anxiety, and HRQoL in children with T1DM. A cross-sectional study design, including children with T1DM aged between 8 and 12 years and healthy controls, was used. Physical activity (PA) level was assessed with the Physical Activity Questionnaire for Older Children (PAQ-C). Anxiety was screened by The Screen for Anxiety Related Emotional Disorders (SCARED) questionnaire. Depressive symptoms were evaluated using the Children’s Depression Inventory (CDI). Quality of life was assessed with the The Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0). Forty-seven T1DM and 55 healthy children were included with mean ages of 9.87±1.63 and 9.56±1.60 years, respectively. The T1DM group had significantly higher depression and anxiety score (p<0.05) and lower HRQoL-child self-report score (p<0.05, for all) compared with the control group. Significant associations were found between PAQ-C and PedsQL 4.0 (p<0.05), between SCARED and PedsQL 4.0 (p<0.05), and between HbA1c and PedsQL 4.0 (p<0.05) in children with T1DM. The result of our study suggested that only HRQoL was related to physical activity, anxiety and HbA1c in children with T1DM.
Creativity and Tradition in the Introduction to Love Poetry for thePoets of the Sham in the Ottoman Era

Field: Arts and Humanities (Social Sciences)

This research deals with an analytical study of the flirtatious introductions that came in the view of the praise poems that spread widely in the Ottoman era, where this study attempts to monitor the aspects of creativity and the status of poetic thought among some poets of the Levant in dealing with a broad poetic purpose is spinning, and how these poets benefited From the experiences of the ex throughout the ages and adding what is related to the spirit of their times on the one hand, and their personal perception about the issues of spinning and women and what they feel on the other hand, and this study relied on the analytical method that helps in clarifying the tradition and creativity in these introductions.
ATRT-20. ATYPICAL TERATOID RHABDOID TUMOR: ASSOCIATION OF CLINICAL, HISTOLOGICAL, RADIOLOGICAL, MOLECULAR, AND THERAPEUTIC DATA WITH THE SURVIVAL OF PATIENTS ATTENDED AT IOP/GRAACC/UNIFESP

Field: Medicine (Health Sciences)

Abstract BACKGROUND In childhood, Atypical Rhabdoid Teratoid Tumor accounts for 2% of cases of brain tumors. There is no consensus for the treatment, resulting in multiple protocols. METHODS Retrospective study at the Institute of Pediatric Oncology-IOP/GRAACC/UNIFESP, from January 2000 to December 2022. There were 31 patients admitted during this period. The classification of the histological type into rhabdoid/classic, small round and blue cells, epithelial, and mesenchymal was carried out by the same pathologist, and a 50% cutoff characterized the predominant pattern. A neuro-radiologist reviewed the radiological data. Molecular analysis was performed using NGS. RESULTS In patients &lt;3yo, 74.9% of patients died. Overall survival (OS) at 3 years was 24.5%, and progression-free survival (PFS) at 3 years was 13.8%. In patients &lt;3yo, the absence of metastases was associated with a higher OS and PFS (3y-OS 35.6% and 3y-PFS 23.7%, vs 3y-OS 10% and 3y-PFS 0% in patients with M+). The OS was higher in patients who received radiotherapy at the first treatment (3y-OS of 66.6% vs 7.8% in the non-irradiated group). The classic histological pattern had a lower PFS than the epithelial and small cell groups (p=0.021). In patients&gt;3 yo, 57.1% of patients died. The 3y-OS was 38.1% and the 3y-PFS was 53.5%. In this age group, there was no difference in OS and PFS considering metastases, location, histological pattern, and tumor volume. For post-surgical status, only PFS was significantly higher in patients with complete resection (3y-PFS of 75%, p=0.008). The mean survival time in patients &lt;3 yo was 1.9 years, and the mean survival time in patients &gt;3 yo was 2.5 years. The genetic alterations found were SMARCB1, NOTCH1, and KMT2D. CONCLUSION Patients &gt;3yo seem to have a higher OS and PFS than those &lt;3 yo. Early diagnosis of ATRT may corroborate to a better outcome. The radiotherapy in the first treatment can improve the outcome of patients under 3 years of age. The classic histological pattern was associated with worse PFS.
Gaps Associated with the Timing of Students’ Orientation Programs in Two Institutions of Higher Learning in South Africa

Field: Social Sciences (Social Sciences)

Social studies is seen as a more digestible integrated or interdisciplinary subject by the mode at which its contents are drawn from certain numbers of subject disciplines.This study seeks to determine the perceptions of teachers about the concept of integration in social studies curriculum.This descriptive study was carried out with 80 social studies teachers at the junior secondary schools level in Ekiti state, Nigeria.An instrument was used to establish the extent at which the concept of integration is perceived by social studies teachers.The results of the study showed that majority of the social studies teachers are not knowledgeable about the concept of integration, therefore, making its application in the teaching of social studies difficult.The researchers concluded that teachers should be resourceful and innovative in order to make learning more relevant for the benefit of the child being taught in the classroom and the nation as a whole.
Identification of sequences necessary for transcription in vitro from the Chlamydia trachomatis rRNA P1 promoter

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Chlamydia trachomatis RNA polymerase was partially purified by heparin-agarose chromatography and used in conjunction with a plasmid-borne G-less cassette template to characterize the C. trachomatis rRNA P1 promoter in vitro. Stepwise mutational analysis revealed that sequences in the -10, -25, and -35 regions are necessary for promoter activity, but no sequence upstream of position -40 is required. Partially purified C. trachomatis RNA polymerase and purified Escherichia coli holoenzyme exhibited some differences in promoter specificity.
Approaches to Reducing Consumption of Alcohol by Youth

Field: Social Sciences (Social Sciences)

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