jimnoneill/paper-to-field-training huggingface dataset:
Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Obesity causes various health problems, such as type 2 diabetes, non-alcoholic fatty liver disease, and cardio- and cerebrovascular diseases. Metabolic organs, particularly white adipose tissue (WAT) and liver, are deeply involved in obesity. WAT contains many adipocytes with energy storage capacity and secretes adipokines depending on the obesity state, while liver plays pivotal roles in glucose and lipid metabolism. This review outlines and underscores the relationship between obesity and lysosomal functions, including lysosome biogenesis, maturation and activity of lysosomal proteases in WAT and liver. It has been revealed that obesity-induced abnormalities of lysosomal proteases contribute to inflammation and cellular senescence in adipocytes. Previous reports have demonstrated obesity-induced ectopic lipid accumulation in liver is associated with abnormality of lysosomal proteases as well as other lysosomal enzymes. These studies demonstrate that lysosomal dysfunction in WAT and liver underlies part of the obesity-related pathology, raising the possibility that strategies to modulate lysosomal function may be effective in preventing or treating the metabolic syndrome.
Expression profiling of peripheral blood (PB) enriched for circulating tumor cells (CTCs) in testicular germ cell tumors (TGCTs).

Field: Medicine (Health Sciences)

4556 Background: CTCs are prognostic in several types of tumors and are easily accessible for repeat examination. TGCTs represent a model for the cure of cancer. Nonetheless, a small proportion of patients develop disease recurrence. We investigated expression profiling of PB enriched for CTCs in TGCTs aimed to identify expression signature associated with treatment resistance. Methods: This prospective study included 30 patients (pt) treated with first line (27 pt) or salvage (3 pt) chemotherapy. CD45 - peripheral mononuclear cells (PBMCs) were isolated from 10mL of PB on day 1 and on day 22 of first cycle of chemotherapy. Isolated PBMC were depleted of cells of hematopoietic origin (CD45 + ) using RossetteSep kit negative selection with anti-CD45 antibody. CD45-depleted PBMC represent compartment enriched for CTCs, as showed previously. RNA was extracted from CD45 - PBMCs and the expression profiles were obtained using Roche NimbleGen microarrays. Data analysis was processed in R using a limma package followed by GO analysis and MetaCore pathway analysis. Results: Six patients achieved unfavorable response to chemotherapy (other than CR or PR with negative serum markers). We identified 1,506 and 211 genes that were expressed at significantly different levels (FDR<0.05) on day 1 and day 22 of chemotherapy, respectively, with 108 overlapping genes. Cluster analysis using principal component analysis showed, that 5 of 6 samples from patients with unfavourable response to chemotherapy form clearly defined cluster opposed to samples from patients with favourable response. Based on pretreatment expression profiling using MetaCore pathway analysis software, we further identified 758 genes, belonging to several critical functional groups such as immune response, signal transduction, cell proliferation, cell cycle progression, or apoptosis, to be significantly differentially expressed in patients with favourable vs. unfavourable response. Conclusions: Our data suggests that expression profiling of PB enriched for CTCs in TGCTs is feasible, and show great promise in identifying new therapeutic targets and gene expression signature associated with treatment resistance.
Blastic Plasmacytoid Dendritic Cell Neoplasm: Challenges in Diagnosis and Treatment with Potential of Venetoclax as an Alternative to Vincristine in High-Risk Patients-A case report

Field: Medicine (Health Sciences)

Abstract Background : Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and challenging cancer for diagnosis and treatment. Accurate diagnosis plays a crucial role guiding appropriate treatment, typically involving high-intensity lymphoblastic leukemia regimens which typically include vincristine. However, the use of vincristine may be particularly limited in patients with pre-existing neuropathy or individuals at high risk of developing it. Here, we present a case of BPDCN that was initially diagnosed as Marginal Zone Lymphoma (MZL) and subsequently as non-specific T-cell lymphoma, thus highlights the importance of accurate diagnosis and modified treatment. Case presentation : A 49-year-old Arab man with a medical history of diabetes, peripheral neuropathy, hypertension, and depression presented with widespread, painless multiple skin lesions. After undergoing a biopsy at another institution, the patient was initially diagnosed with MZL, and received two cycles of bendamustine and rituximab. However, the disease relapsed and was later diagnosed with non-specific T-cell lymphoma, which proved refractory to a single cycle of CHOP chemotherapy. The patient was subsequently referred to our centre, where a comprehensive evaluation revealed BPDCN with a unique finding on bone marrow exam: signet ring plasmacytoid dendritic cells. Due to the patient's pre-existing neuropathy and previous treatment, we administered the Hyper-CVAD regimen with a 50% reduction in vincristine dosage, which resulted in an excellent response. During the second part of cycle one, when new skin lesions started appearing, venetoclax was added to the treatment regimen. Subsequently, vincristine was completely removed, and venetoclax was continued in cycle two, leading to a complete response. The patient achieved a disease-free state for the first time in disease course, maintaining it for a period of over six weeks before experiencing a relapse. Conclusion : Accurate diagnosis is crucial for guiding appropriate treatment. Our case highlights the challenges associated with diagnosis and treatment, as well as the potential of venetoclax as an alternative to vincristine, particularly in patients with pre-existing neuropathy or those at a high risk of developing it. Further research is needed to evaluate the effectiveness of BCL2 inhibitors as a replacement for essential drugs and its potential as a bridging therapy until patients can undergo a stem cell transplant.Top of Form
Plant growth promoting rhizobacteria mediated biological control of Sclerotium oryzae (Cattanoe)

Field: Agricultural and Biological Sciences (Life Sciences)

Twenty bacterial isolates were evaluated for their antagonistic activity against Sclerotium oryzae (Cattanoe). The antagonists were selected based on their ability to inhibit the external growth of S. oryzae from infected rice plants. Three bacterial isolates viz., SRR-1, SRR-3 and SRR-6 were identified as potent antagonists of S. oryyzae by dual culture technique. Both SRR-1 and SRR-3 inhibited the mycelial growth of S. oryzae upto the extent of 88% followed by SRR-6 (86.66%). All the fungicides tested showed 100 per cent inhibition of mycelial growth of the pathogen except validamycin which inhibited only 88.88% when compared to control. The potential bacterial bioagent SRR-1 was found to be most compatible with the systemic fungicide thiophanate methyl (95.70%) and also with insecticide cartap hydrochloride (91.69%). Among the three antagonists, the bioagent SRR-1 produced diffusible volatile metabolites which inhibited the pathogen growth upto 100% under in vitro.
In Vivo Characterization of Partial-Thickness Burn Injuries Using THz Time-Domain Spectral Imaging in a Porcine Model

Field: Medicine (Health Sciences)

THz imaging is a promising modality to improve the standard-of-care for patients with partial thickness burn injuries. In this study, we show the accuracy and efficacy of THz-TDSI for characterizing and monitoring burn wounds in a porcine model. We show that our new THz hyperspectral metric, Z, can differentiate between partial-thickness burns against their histologically determined depths of injury ( ).
A Study on Embryonic Development of Alosa sapidissima

Field: Agricultural and Biological Sciences (Life Sciences)

Fertilized eggs were obtained from cage-cultured Alosa sapidissima by half dry artifical fertilization in May 2013.The developmental time and morphological characters of 29 embryonic developmental stages were observed using microscope from fertilization to hatching. The results showed that the embryonic development of Alosa sapidissima could be divided into 7 stages,including the one-cell stage,cleavage stage,blastula stage,gastrula stage,neural stage,organogenesis stage and the hatching stage according to the morphological features.The fertilized eggs of Alosa sapidissima were transparent without stickiness and oil globule; the egg diameter was 3.15±0.15 mm; the egg gap was 0.8 mm. Under the water temperature( 21.5±0.5) ℃,30 minutes after fertilizing,the fertilized eggs developed to the formation of blastoderm,50 minutes to the cleavage stage,5hours and 10 minutes to the blastula stage,12 hours to the gastrula stage,16 hours to the neurula stage,24 hours and 10 minutes to the organogenesis stage,59 hours and 50 minutes to the hatching stage,and 66 hours and 30 minutes,fries began to hatch out.Under the water temperature( 21.5±0.5) ℃,the total effective accumulated temperature for the embryonic development of Alosa sapidissima was 1 463( ℃ · h). The total length of the newly hatched larvae was( 3.15±0.15) mm and the larvae were transparent.This study might provide theoretical guidance for artificial propagation of Alosa sapidissima.
The Repertoire of Killer Cell Ig-Like Receptor and CD94:NKG2A Receptors in T Cells: Clones Sharing Identical αβ TCR Rearrangement Express Highly Diverse Killer Cell Ig-Like Receptor Patterns

Field: Immunology and Microbiology (Life Sciences)

Abstract Killer cell Ig-like receptor (KIR) and CD94:NKG2A molecules were first defined as human NK cell receptors (NKR), but now are known to be expressed and to function on subpopulations of T cells. Here the repertoires of KIR and CD94:NKG2A expression by T cells from two donors were examined and compared with their previously defined NK cell repertoires. T cell clones generated from peripheral blood of both donors expressed multiple NKR in different combinations and used the range of receptors expressed by NK cells. In both donors αβ T cells less frequently expressed the inhibitory receptors CD94:NKG2A and KIR2DL1 than either γδ T cells or NK cells. In contrast to NK cells, not all NKR+ T cells expressed an inhibitory receptor for autologous HLA class I. This lack of specific inhibitory NKR was especially apparent on αβ T cells of one donor. Overall, αβ T cells exhibited a distinct pattern of NKR expression different from that of γδ T and NK cells, which expressed highly similar NKR repertoires. In one donor, analysis of TCR rearrangement revealed a dominant subset of NKR+ T cells sharing identical TCR α- and β-chains. Remarkably, among 55 T cell clones sharing the same TCRαβ rearrangement 18 different KIR phenotypes were seen, suggesting that KIR expression was initiated subsequently to TCR rearrangement.
The Ptolemaen Musica. Introduction, Russian translation and notes

Field: Arts and Humanities (Social Sciences)

An often neglected small treatise, conventionally entitled The Ptolemaean ‘Musica’ (apparently dated to the Late Antiquity), is translated into the Russian for the first time. The work is a compilation of various sources, which include the Aristoxenian rhythmics, the Neopythagorean numerology and harmonics as well as the Ptolemaean geocentric astrology. According to its author the planetary cycles in their unity are closely related to the musical proportions. This approach further allows correlating the planetary rhythms with the musical rhythmics.
[Differential diagnosis of tumors of the soft tissue of the forearm: an atypical palmaris longus muscle].

Field: Medicine (Health Sciences)

Bellies of the palmaris longus which are situated in an atypical position can appear as tumors of soft tissues on the flexor side of the forearm. Besides a central position a distal bicipital and a doubled variant can be observed. We report the case of a 22 years old female patient, with a "tumor" on the flexor side of the forearm of plum-size. Previous surgery had been interrupted when musculature appeared. During the revision we found a belly of the palmaris longus in a central position, situated proximal to the flexor retinaculum. The belly of musculature was 5 cm long and 2 cm wide. After extirpation of the tendinous and muscular parts the patient was free of symptoms.
AI for Language Learning: Friend or Foe?

Field: Computer Science (Physical Sciences)

This is a study of the implementation of artificial intelligence (AI), especially in language learning and teaching, especially in the 2021 stages. AI has taken significant roles in learning activities that focus on student-centered learning, namely the customization of the learning speed, direct feedback, and assessment which have benefited their intended users. It has also addressed language learning-teaching challenges, including pronunciation, vocabulary, grammar, cultural differences, and motivation. However, some issues need to be addressed and regulated to ensure the safe and effective use: privacy and security of the user, technical expertise, bias, cultural sensitivity, a lack of human interaction, ethical considerations, and over-reliance on technology. Furthermore, the benefits and limitations have yet to be determined based on their dominance or balance: On one side, AI enables the learners to decide how they want to learn, while the instructors have a virtual assistant to construct curricula, materials, and assessments. On the other hand, its impact on the students in general in other learning aspects must also be considered. Therefore, it is essential to investigate further its effectiveness in how One approach is to integrate AI-based language learning tools with traditional language instruction, providing learners with a comprehensive and balanced language learning experience. For example, AI-based tools can provide learners targeted instruction and feedback on specific aspects of language use. In contrast, traditional language instruction can provide learners with opportunities for authentic language use and interaction with native speakers and peers (Lambelet & Chassot, 2019). Keywords: AI, Foreign Language Learning, Student-centered Learning
Theatre of Dreams: Weddings as a Service Experience

Field: Business, Management and Accounting (Social Sciences)

This paper seeks to examine the value offered by the services drama metaphor to the service that is a wedding. A wedding is an atypical service in that it is temporally extended and involves a multiplicity of service providers brought together to produce the 'big day'. The authors contribute to greater understanding of the drama metaphor by conceptually developing and integrating the themes of the drama metaphor and the romance and consumption that are evident in a bride's wedding experience. The conceptual discussion is further strengthened by the results of in-depth interviews with brides.
Simply Impossible: A Case against Divine Simplicity

Field: Arts and Humanities (Social Sciences)

Abstract Within contemporary philosophical theology the doctrine of divine simplicity has regained attention.1 The pertinent literature has increased by several new defenses of the doctrine.2 One of the more surprising, and troubling, aspects of the contemporary defenses amongst Christian philosophers and theologians is a seeming lack of understanding about how radical the doctrine of divine simplicity truly is. As such, I wish to do a few things in this paper. First, systematically articulate the doctrine of divine simplicity. Second, argue that divine simplicity is not a possible perfection. Third, offer some concluding remarks and highlight remaining issues that will need to be sorted out for the debate over simplicity to meaningfully continue.
Sparta's Second Attic War

Field: Arts and Humanities (Social Sciences)

In a continuation of the multivolume series on ancient Sparta, this book details the second stage in the six-decades-long, epic struggle between Sparta and Athens that first erupted some seventeen years after their joint victory in the Persian Wars. The book explores how and why open warfare between these two erstwhile allies broke out a second time, after they had negotiated an extended truce. It traces the course of the war that then took place, examining the strategy each community pursued and the tactics adopted, before explaining how and why mutual exhaustion forced on these two powers yet another truce doomed to fail. At stake for each of the two peoples caught up in this enduring strategic rivalry, as the book shows, was nothing less than the survival of its political regime and of the peculiar way of life to which that regime gave rise.
Advances in core drilling technology

Field: Engineering (Physical Sciences)

Some notable technical advances in drill design were reported at the meeting, held in Canada August 30–September 1, 1982, at the University of Calgary. Chief amongst these was a battery powered, computer assisted electromechanical core drill which has recently been used by the Danes in Greenland to continuously core to the base of the ice sheet at 2038 m. This is the deepest coring operation so far on the Greenland ice sheet. (The record for deep glacier drilling is held by the U.S. Army Cold Regions Research and Engineering Laboratory for the continuous coring through 2164 m of ice to bedrock at Byrd Station, Antarctica, in 1968). In early 1982, a current Soviet core drilling operation was reported to be at a depth of 2000 m at Vostok station, Antarctica, where the total ice thickness is about 4000 m; the goal of core drilling the entire ice thickness there could be achieved before the end of 1983.
Organizational-and-technological solutions for waterproofing joints of highly prefabricated coating panels

Field: Engineering (Physical Sciences)

This paper describes the technology and organization of the production of works on waterproofing the joints of highly prefabricated coating panels on a soft roof. The process of manufacturing waterproofing works can be divided into three stages - preparatory, main and final ones. Each stage has its own technological features and rules for performing work. The quality of execution of each stage affects the quality of work as a whole, ultimately providing the necessary reliability and strength of the coating.
Al-Qalam University, Katsina Post Utme Form,2022/2023,(Admission Forms) Undergraduate is Out Call ☎0706-628-0862 DR RUTH Candidates must possess credit pass in at least five (5) "O" level subjects including English Language, Mathematics, Physics, Chemistry, Biology, at not more than two sittings in the SSCE (WAEC/NECO, GCE or NABTEB).

Field: Social Sciences (Social Sciences)

Al-Qalam University, Katsina Post Utme Form,2022/2023,(Admission Forms) Undergraduate&nbsp;is Out Call&nbsp;☎️0706-628-0862&nbsp;DR RUTH&nbsp;Candidates must possess credit pass in at least five (5) &quot;O&quot; level subjects including English Language, Mathematics, Physics, Chemistry, Biology, at not more than two sittings in the SSCE (WAEC/NECO, GCE or NABTEB).
Centuries of Childhood/ Centuries of Parenting: Philippe Ariès and the Modernization of Privileged Infancy

Field: Social Sciences (Social Sciences)

In Centuries of Childhood Philippe Ariès studied the evolution of par ental investment among the materially and socially privileged families of France from the sixteenth to the nineteenth century. His general hypothesis, interpreted in the vocabulary of modern research, was that both the financial and emotional costs of elite childrear ing were rising during this period Once greater emotional involvement led to high investments in infant survival, infant mortality declined, survivorship rose, and privi leged families were forced to adopt fertility control in order to avoid the production of too many very costly children. In this article Ariès' verbal "model" is tested using quantitative data from both French and other European elite groups.
Pennisetum violaceum (Lam.) Rich. IP 21711

Field: Agricultural and Biological Sciences (Life Sciences)

Plant Genetic Resource.
Taxonomy: Pennisetum violaceum (Lam.) Rich.
Common name(s): Pearl millet
Other names: IPW 194, IP 21711
Conserved by: International Crop Research Institute for the Semi-Arid Tropics (ICRISAT), India
Local sample unique identifier: IP 21711
Method of creation: Acquisition
Date: 1990-04-30
Other identifiers: n/a,IPW 194
Historical: No
Biological status: Wild
MLS status: Included
Benny Levy versus Emmanuel Levinas on “Being Jewish”

Field: Arts and Humanities (Social Sciences)

Journal Article Benny Levy versus Emmanuel Levinas on "Being Jewish" Get access Annabel Herzog Annabel Herzog Search for other works by this author on: Oxford Academic Google Scholar Modern Judaism - A Journal of Jewish Ideas and Experience, Volume 26, Issue 1, February 2006, Pages 15–30, https://doi.org/10.1093/mj/kjj002 Published: 01 February 2006
Extended data for 'Compositional and functional alterations in the oral and gut microbiota in patients with psychosis or schizophrenia: A systematic review'

Field: Medicine (Health Sciences)

Background: Gut and oral microbiota are intrinsically linked to human health. Recent studies suggest a direct link with mental health through bidirectional gut–brain pathways. Emerging evidence suggests that the composition and/or function of intestinal microbiome differs in those with psychosis and schizophrenia as compared with controls. There is relatively little research on the predicted or actual functional alterations associated with the composition of oral and gut microbiota in patients with psychosis. We will perform a systematic review and meta-analysis to identify, evaluate and if possible, combine the published literature on compositional alterations in the oral and gut microbiota in patients with psychosis or schizophrenia compared with healthy controls. We also aim to explore the potential functional impact of any compositional changes. Methods: Original studies involving humans and animals using a case-control, cohort or cross-sectional design will be included. The electronic databases PsycINFO, EMBASE, Web of Science, PubMed/MEDLINE and Cochrane will be systematically searched. Quantitative analyses will be performed using random-effects meta-analyses to calculate mean difference with 95% confidence intervals. Discussion: Changes in microbiota composition in psychosis and schizophrenia have been correlated with alternations in brain structure and function, altered immunity, altered metabolic pathways and symptom severity. Changes have also been identified as potential biomarkers for psychosis that might aid in diagnosis. Understanding how predicted or actual functional alterations in microbial genes or metabolic pathways influence symptomatic expression and downstream clinical outcomes may contribute to the development of microbiome targeted interventions for psychosis.