jimnoneill/paper-to-field-training huggingface dataset:
Transcriptional activation of the bkd operon of Pseudomonas putida by BkdR

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Reinvestigation of the transcriptional start site of the bkd operon of Pseudomonas putida revealed that the transcriptional start site was located 86 nucleotides upstream of the translational start. There was a sigma 70 binding site 10 bp upstream of the transcriptional start site. The dissociation constants for BkdR, the transcriptional activator of the bkd operon, were 3.1 x 10(-7) M in the absence of L-valine and 8.9 x 10(-8) M in the presence of L-valine. Binding of BkdR to substrate DNA in the absence of L-valine imposed a bend angle of 92 degrees in the DNA. In the presence of L-valine, the angle was 76 degrees. BkdR did not bind to either of the two fragments of substrate DNA resulting from digestion with AgeI. Because AgeI attacks between three potential BkdR binding sites, this suggests that binding of BkdR is cooperative. P. putida JS110 and JS112, mutant strains which do not express any of the components of branched-chain keto acid dehydrogenase, were found to contain missense mutations in bkdR resulting in R40Q and T22I changes in the putative helix-turn-helix of BkdR. Addition of glucose to the medium repressed expression of lacZ from a chromosomal bkdR-lacZ fusion, suggesting that catabolite repression of the bkd operon was the result of reduced expression of bkdR. These data are used to present a model for the role of BkdR in transcriptional control of the bkd operon.
SOCIETAL REACTIONS AND THE PSYCHOSOCIAL DEVELOPMENT OF WOMEN EXPERIENCING INFERTILITY IN FAKO DIVISION, SOUTHWEST REGION

Field: Social Sciences (Social Sciences)

This study examined how societal reactions influence the psychosocial development of women experiencing infertility in Fako Division, Southwest region Cameroon. Using a convergent mixed-method design, quantitative data were collected from 354 community actors and qualitative data from five clinically diagnosed women suffering from infertility. Findings showed predominantly negative societal reactions, with 76.4% of respondents acknowledging stigma and discriminatory behaviours such as blame, mockery, marital instability, and exclusion from family activities. Chi-square tests revealed that age, sex, education, occupation, religion, and marital factors significantly shaped societal attitudes toward women suffering from infertility. Qualitative accounts further highlighted rejection by spouses and in-laws, emotional withdrawal from family members, and pressure to seek spiritual or traditional remedies. Regression analysis demonstrated a strong and significant effect of societal reactions on psychosocial development (R = 0.595, p < 0.001), explaining 86.60% of the variation. Conclusively, the study showed that negative societal responses profoundly undermine the emotional, social, and psychological wellbeing of women facing infertility, underscoring the need for community education and culturally sensitive support systems.
[Health services, morbidity and mortality in the regiment of the Papal Zouaves in Italy (1861-1870)].

Field: Medicine (Health Sciences)

The regiment of the Zouaves pontificaux was formed by young Catholic volunteers, chiefly French, Dutch and Belgian, who enrolled for the defence of the Pontifical State from 1861 to 1870 against the scheme of the United Italy planned by King Victor-Emmanuel II and Garibaldi. For ten years fights were scarce. They only took place in 1867 principally in Mentana and in September 1870 when the papal state was invaded and Rome taken. At first the military medical service in the regiment as in the whole army was rather inadequate except for the central hospital. The ambulances system was based largely upon benevolent people. But the organization improved in 1870. On the whole amongst more than 9,000 enlisted volunteers, 476 died (5%). The causes of death were more often diseases (78%) than injuries. As in all the armies of that time, cholera, smallpox, typhoid fever made a lot of victims. Malaria which still reigned in the Latium was responsible of a large morbidity.
Further development of a morphine hydrogel suppository.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

1. A sustained release monolithic morphine hydrogel suppository (MHS) was developed and administered to five volunteers. 2. The MHS delivered a mean of 55 mg morphine over 12 h. The mean plasma morphine concentration was 15 ng ml‐1 from 2 to 12 h after administration. 3. Plasma morphine concentrations were comparable with those reported for the same dose given orally over the same time period. 4. The morphine hydrogel suppository appears to be an effective means of delivering morphine and may be of value in the management of chronic pain.
Investigating the Effect of Job-Related Motivational Factors on the Employee and Organizational Performance through Mediating Role of Organizational Participation (Entekhab Industrial Group Case Study)

Field: Business, Management and Accounting (Social Sciences)

The present study aimed to investigate the effect job-related motivations on the employee and organizational performance through mediating role of organizational participation. For this purpose, a conceptual model has been developed and tested. In this regard, a main hypothesis (the effect job-related motivations on the employee and organizational performance through mediating role of organizational participation) and nine secondary hypotheses (the effects of organizational rewards on the employee participation, employee performance, and organizational performance; the effect of employee participation on the employee performance and organizational performance; the effect of employee performance on the organizational performance) were developed and tested. The statistical population of this study includes managers of Entekhab Industrial Group. The statistical population include180 managers, supervisors and chief of Entekhab industrial group. Since the population is limited no sampling is necessary. Thus the whole population is studied. The data collection tool is a researcher-made questionnaire containing 25 items, of which the validity has been confirmed using the comments from advisors, professionals and experts; and the reliability, determined through Cronbach's alpha coefficient of 83%) The questionnaire includes personal data and main, specialized items for examining the research hypotheses. The collected data were analyzed using SPSS and AMOS software programs through statistical tests at descriptive (frequency, percentage, accumulated percentage, average and standard deviation) and inferential (t-test, regression modeling, variance analysis, non-parametric Kolmogorov and Smirnov test, and Freedman non-parametric test) levels.
DOA Estimation of Two-Dimensional Coherently Distributed Sources Based on Spatial Smoothing of Uniform Rectangular Arrays

Field: Computer Science (Physical Sciences)

Aiming at the direction-of-arrival (DOA) estimation of two-dimensional (2D) coherently distributed (CD) sources which are coherent with each other, we explore the propagator method based on spatial smoothing of a uniform rectangular array (URA). The rotational invariance relationships with respect to the nominal azimuth and nominal elevation are obtained under the small angular spreads assumption. A propagator operator is constructed through spatial smoothing of sample covariance matrices firstly. Then, combination of propagator and identical matrix is divided according to rotational operators, and the nominal angles can be obtained through eigendecomposition lastly. Realizing angle matching automatically, the proposed method can estimate multiple DOAs of 2D coherent CD sources without spectral peak searching and prior knowledge of deterministic angular signal distribution function. Simulations are conducted to verify the effectiveness of the proposed method.
Increased Expression of a Disintegrin and Metalloprotease 8 in Allergic Rhinitis

Field: Medicine (Health Sciences)

Background A disintegrin and metalloproteases (ADAMs) constitute a family of cell surface proteins containing disintegrin and metalloprotease domain, which associate features of adhesion molecules and proteases. ADAM8 is a member of the ADAM family and has recently been implicated to have a role in allergic lung inflammation. Therefore, our aims were to determine the expression of ADAM8 mRNA and protein and to localize ADAM8 protein in the nasal mucosa of patients with allergic rhinitis and control subjects. Methods Inferior turbinate mucosa samples were obtained from 20 patients with allergic rhinitis and 20 matched healthy normal controls. ADAM8 mRNA was extracted from the inferior turbinate mucosa, and then reverse transcription–polymerase chain reaction was performed. Western blot testing was used to analyze differences in the level of ADAM8 protein expression between patients with allergic rhinitis and normal controls, and the ADAM8 protein was localized with immunohistochemical staining. Results The level of expression of ADAM8 mRNA and protein in the nasal mucosa was significantly increased in patients with allergic rhinitis compared with normal controls. ADAM8 protein was expressed in the epithelium, infiltrating inflammatory cells, and submucosal glands. Conclusion ADAM8 is expressed in human nasal mucosa and is increased in patients with allergic rhinitis. These results suggest a possible contribution for ADAM8 in chronic inflammation of the nasal mucosa in patients with allergic rhinitis.
Acoustic characteristics of outdoor spaces in an apartment complex

Field: Engineering (Physical Sciences)

Many apartment complexes in Korea feature underground car parks releasing more of the landscape for residents' leisure, rest, or conversation. The acoustic characteristics of these outdoor spaces can therefore make a significant contribution to the overall quality of the environment. This experimental study investigated the acoustic characteristics of outdoor spaces surrounded by multi-storey apartment buildings. In-situ measurements in three positions were carried out to evaluate the acoustic parameters, including reverberation time (RT), early decay time (EDT), rapid speech transmission index (RASTI) and sound pressure level (SPL) distribution. The results show that RTwas generally rather long, over 4 sec at 500 Hz. On the other hand, RTat 125 Hz and 250 Hz was relatively short, about 0 to 3 sec. Above 500 Hz, RT increased with increasing source-receiver distance. EDT was longer than RT over a certain source-receiver distance at about 40 m. In terms of sound distribution, measured SPL was up to 8 dB higher compared to the semi-free field situation, indicating the effects of multiple reflections.
A Copernican Revolution in the Collatz Conjecture: Unveiling Universal Order in Reverse Operations

Field: Mathematics (Physical Sciences)

This research aims to elucidate the hidden order within the reverse operations of the unresolved Collatz Conjecture. We propose a new method for classifying any integer generated by the reverse Collatz operation into six mutually exclusive sequences based on their remainders modulo 9. We then analyze the transition rules of the reverse Collatz operations ((4P−1)/3 and (2P−1)/3) within each sequence. The sequences defined in this study are constructed with the intention of covering all positive integers that converge to 1, assuming the Collatz Conjecture is true. Therefore, the discovery of non-periodicity presented in this paper applies to the elements of these sequences and does not directly prove the truth of the Collatz Conjecture itself (i.e., whether all positive integers converge to 1), but it provides a strong indication of its non-periodicity. Analysis of this system reveals that all numbers, regardless of their starting sequence, ultimately avoid falling into a loop. This universal non-periodicity contrasts with other similar problems, such as the 5N+1 problem, where loops have been observed through repeated operations. This finding suggests that the unique arithmetic properties inherent in the "3N+1" operation of the Collatz Conjecture may contribute to the exclusion of infinite cycles. This offers a new perspective on the non-periodicity of the Collatz Conjecture and is expected to contribute to its resolution.
The scope of diversification of the warehouse space market in a regional configuration

Field: Social Sciences (Social Sciences)

The purpose of the study is an attempt to show the scope of diversity occurring in the warehouse space market in a regional system. The size of the existing warehouse space, the scope of its use and the level of rents were analysed. The basic factors affecting the location of such objects in a given area were also indicated. Poland has the largest warehouse space market among the countries of Central and Eastern Europe (CEE). The amount of warehouse space in Poland is increasing every year. In 2014, it amounted to 8.5 million m2 and in the third quarter of 2019, 17.7 million m2. Currently, over 83% of the warehouse space market is concentrated in five main regions. These include the Warsaw region, Central Poland, Upper Silesia, Wroclaw and the Poznan region. These centres, having a large population, generate significant demand for goods stored in warehouses. At the same time, locations around Szczecin, Tri-City, Rzeszow and Lublin are becoming the subject of growing interest of many developers and tenants. The increase in their investment potential is influenced by the availability of labour as well as differences in the level of employees' remuneration and the availability of land at attractive prices.
[Effect of 5-aminolevulinic acid on photosynthetic characteristics of tomato seedlings under NaCl stress].

Field: Agricultural and Biological Sciences (Life Sciences)

In this research, the possibility of exogenous application of 5-aminolevulinic acid (ALA) on photosynthetic characteristics of tomato seedlings under NaCl stress was investigated. Five leaves seedlings of tomato (Solanum lycopersicum cv. Jinpeng No. 1) were used as starting materials, applied with 50 mg · L(-1) ALA by foliage spray or 10 mg · L(-1) ALA by root soaking to study the changes in their photosynthesis and fluorescence parameters under 100 mmol · L(-1) NaCl. The result showed that, photosynthetic gas exchange parameters (net photosynthetic rate P,, stomata conductance g(s), intercellular CO2 concentration Ci, transpiration Tr) and chlorophyll fluorescence parameters (Fv'/Fm', Fm', ΦPS II, ETR, qP, Pc) were severely reduced under NaCl treatment and ALA application by foliage spray or root soaking with proper concentrations exerted positive influences on tomato seedlings under salt stress, while there were some differences between foliage spray and root soaking in the influence on chlorophyll content, photosynthesis and chlorophyll fluorescence. Both foliage spray with 50 mg · L(-1) ALA and root soaking with 10 mg L(-1) ALA significantly increased Pn, Ci, g(s) and Tr of tomato seedlings under NaCl stress, alleviated photosynthetic inhibition. Root application of ALA had a better effect on the chlorophyll content than foliage application. However, the photosynthetic parameters showed that foliage application of ALA had a better effect than root application, and both treatments had no difference in the influence on chlorophyll fluorescence parameters of tomato seedlings. It could be deduced that the regulating effect of ALA on enhancing salt tolerance of tomato seedlings is attributed to its effect on improving chlorophyll biosynthesis and metabolism, increasing stomatal conductance and reducing stomatal limitation, thus, enhancing the photosynthetic capacity and PS II photochemical efficiency of tomato leaves under NaCl stress.
How Disclosure Requirements Affect Investors and Sponsors:Evidence from Real Estate Crowdfunding

Field: Economics, Econometrics and Finance (Social Sciences)

The development of real estate crowdfunding in the past few years is attributed mostly to the passage of the JOBS Act. Although the SEC set disclosure requirements for crowdfunding, we notice there are still different levels of disclosure among platforms. In this thesis, we examine whether the different disclosure policies set by platforms affect projects’ proposed return and sponsors’ behavior. Due to the two-way causality relationship between disclosure requirements and proposed return, we use the simultaneous regression model to estimate. The empirical results show sponsors who launch projects on a platform with lower disclosure standard raise projects proposed returns as an attractive means. Sponsors who were supposed to prefer a less stringent regulation are surprisingly willing to disclose more information. This study is the first information asymmetry study on debt-based crowdfunding and provide implications for practice.
TRANSITION AND POLITICAL MARKETS: POST‐WAR GERMAN VERSUS POST‐SOCIALIST SLOVENIAN RECONSTRUCTION

Field: Economics, Econometrics and Finance (Social Sciences)

In this paper we try to explain why the economic and political transition in Germany after World War II was successful, and why the transition in post‐communist Slovenia was not. We analyse interactions between political markets and economies in both countries. The differences between the two transitions can be explained by different institutional transformations and different roles of interest groups. In Slovenia, the slow pace of political reform inhibited economic liberalisation.
Blind Calibration of Sensor Arrays for Narrowband Signals with Asymptotically Optimal Weighting

Field: Computer Science (Physical Sciences)

We revisit the problem of blind calibration of uniform linear sensors arrays for narrowband signals and set the premises for the derivation of the optimal blind calibration scheme. In particular, instead of taking the direct (rather involved) Maximum Likelihood (ML) approach for joint estimation of all the unknown model parameters, we follow Paulraj and Kailath's classical approach in exploiting the special (Toeplitz) structure of the observed covariance. However, we offer a substantial improvement over Paulraj and Kailath's Least Squares (LS) estimate by using asymptotic approximations in order to obtain simple, (quasi-)linear Weighted LS (WLS) estimates of the sensors' gains and phases offsets with asymptotically optimal weighting. As we show in simulation experiments, our WLS estimates exhibit near-optimal performance, with a considerable improvement (reaching an order of magnitude and more) in the resulting mean squared errors, w.r.t. the corresponding ordinary LS estimates. We also briefly explain how the methodology derived in this work may be utilized in order to obtain (by certain modifications) the asymptotically optimal ML estimates w.r.t. the raw data via a (quasi)-linear WLS estimate.
The role of empowerment and quality of life in depression severity among unemployed people with affective disorders receiving mental healthcare

Field: Health Professions (Health Sciences)

An empowerment approach and strategies, which support the quality of life, are needed in development of vocational rehabilitation interventions, and bridging of mental healthcare and vocational services. Implications for Rehabilitation Enhancing empowerment and quality life in the return to work process can decrease depression severity in unemployed people with affective disorder. There is a need to address work issues in addition to symptom reduction in primary and mental healthcare. Bridging the service and time gap between vocational rehabilitation and healthcare is recommended for mitigating long-term unemployment for people with affective disorders who want to work.
Interstellar polarization and magnetic alignment of pinwheel dust grains - I. Suprathermal grain rotation

Field: Physics and Astronomy (Physical Sciences)

With the aim of understanding magnetic alignment of non-spherical dust grains inside dense interstellar clouds, the present paper outlines a new model for the Purcell pinwheel mechanism. We assume that polarizing dust grains are oblate spheroids having a classical core-mantle structure. The core consists of small refractory solids (silicates or mixed oxides), whereas the mantle material is composed of a dirty ice mixture. We discuss a model in which cold (T0≃10 K) mantles are covered with H2 molecules accreted from the ambient cloud. When galactic subcosmic rays strike the mantle, they create temporary hotspots on the surface. The hydrogen molecules physisorbed within a hotspot boundary are then ejected from the mantle surface like rockets. In this model, suprathermal rotation of pinwheel grains is still driven by random impulse torques produced by H2 molecule ejections. We find that pinwheel rotation rates strongly depend on the mantle composition and the chemical nature of the dense cloud interior. Inside reducing clouds, icy mantles are H2O- or CO2-dominated, and pinwheels can rotate suprathermally (ω≃108 rad s-1), even if gas and dust have a common temperature. If CO condenses on to H2O ice mantles inside oxidizing clouds, however, then icy grains cannot rotate suprathermally. We show that these conditions are consistent with infrared spectroscopic observations of icy grain mantles in dark clouds. We also discuss the survival of pinwheel grains in diffuse interstellar clouds. We conclude that interstellar shocks can destroy the grains; and that the polarization of starlight cannot be understood unless galactic dust is continuously cycled between diffuse and dense cloud phases.
Interleukin 2 Production by Both Ly2+ and Ly2− T‐Cell Subsets

Field: Immunology and Microbiology (Life Sciences)

Homogeneous T‐Cell populations produced by activating lymphocytes to I‐. K‐, or K+D‐region‐encoded determinants of the mouse H‐2 complex release interleukin 2 when restimulated by concanavalin A. Contrary to earlier reports on the cellular origin of the lymphokine, we find that interleukin 2 production can be either Ly2 + or Ly2 − T‐cell‐dependent.
In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain

Field: Neuroscience (Life Sciences)

Significance This study demonstrates how sensory information is represented and stored in cortical circuits during complex behavior in the mammalian brain. Using a newly established automatic algorithm for cell detection, we tracked the expression of immediate early genes from more than 20,000 neurons in each living mouse for 2 mo, revealing quantitative signal changes in each neuron within a local cortical circuit. A natural behavioral task induced sparse and task-specific neuronal activation in cortical layer II. The gradually formed sparse activation of neurons was observed in multiple cortical areas. Our results support the concept of consolidation for long-term memory storage in cortical circuits and demonstrate the representation of natural events as sparse coding in the mammalian brain.
Medro o desmedro del lenguaje pediátrico

Field: Medicine (Health Sciences)

</jats:p> </jats:abstract> <publication_date media_type='online'> <month>09</month> <day>10</day> <year>2024</year> </publication_date> <doi_data> <doi>10.60147/60bba735</doi> <resource>https://pap.es/articulo/14230/medro-o-desmedro-del-lenguaje-pediatrico</resource> </doi_data> </journal_article> <!-- ============== --><journal_article publication_type='full_text'> <titles><title>Fallo de medro: ¿un término a desaparecer? </title> </titles> <contributors> <person_name sequence='first' contributor_role='author'> <given_name>José Manuel</given_name> <surname>Moreno</surname> </person_name></contributors> <jats:abstract xml:lang='es'> <jats:p>