jimnoneill/paper-to-field-training huggingface dataset:
A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndex

Field: Medicine (Health Sciences)

Objective: This study aimed to investigate whether triglyceride glucose (TyG) index predicts the development of in-stent restenosis (ISR) in patients undergoing percutaneous coronary intervention (PCI) for de novo lesions. Materials and Methods: This was a prospective case controlled study and includes 124 patients with a mean age of 57 ± 9.1. Control coronary angiography was performed in all patients enrolled in the study 6–12 months after the PCI. Blood sample triglycerides (TGs) and blood glucose concentrations were collected after at least 8 h of fasting. The TyG index was calculated as follows: log (serum TGs [mg/dL] × plasma glucose [mg/dL]/2). The study cohort was divided into two groups as those with and without restenosis. Angiographically, stent restenosis, defined as the presence of ≥50% diameter narrowing either within the stent or within 5 mm proximally or distally to the stent margin. Results: The median follow-up time was 7.17 months (±2.01). Forty-eight patients (38.7%) had restenosis. Patients with ISR had more diabetes (P < 0.01) and CAD (P = 0.03). These also had higher TyG index (P = 0.04) and less drug-eluting stent implantation (P = 0.04). Diabetes (odds ratio [OR]: 1.927, P = 0.03), stent type (OR: 0.342, P = 0.02), and TyG index (OR: 4.144, P = 0.01) significantly predicted ISR. The receiver operating characteristics curve analysis revealed a cutoff value of TyG index >4.71 predicts the development of ISR. Conclusion: A TyG above 4.71 was found a risk factor for ISR during 1-year follow-up period after index elective PCI.
Data from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8<sup>+</sup> T Cells

Field: Medicine (Health Sciences)

<div>Abstract<p>Tumor-infiltrating T cells, particularly CD45RO<sup>+</sup>CD8<sup>+</sup> memory T cells, confer a positive prognostic value in human cancers. However, the mechanisms that promote a protective T-cell response in the tumor microenvironment remain unclear. In chronic inflammatory settings such as the tumor microenvironment, lymphoid neogenesis can occur to create local lymph node–like structures known as tertiary lymphoid structures (TLS). These structures can exacerbate a local immune response, such that TLS formation in tumors may help promote an efficacious immune contexture. However, the role of TLS in tumors has yet to be investigated carefully. In lung tumors, mature dendritic cells (DC) present in tumor-associated TLS can provide a specific marker of these structures. In this study, we evaluated the influence of TLS on the characteristics of the immune infiltrate in cohorts of prospective and retrospective human primary lung tumors (<i>n</i> = 458). We found that a high density of mature DC correlated closely to a strong infiltration of T cells that are predominantly of the effector–memory phenotype. Moreover, mature DC density correlated with expression of genes related to T-cell activation, T-helper 1 (Th1) phenotype, and cytotoxic orientation. Lastly, a high density of TLS-associated DC correlated with long-term survival, which also allowed a distinction of patients with high CD8<sup>+</sup> T-cell infiltration but a high risk of death. Taken together, our results show how tumors infiltrated by TLS-associated mature DC generate a specific immune contexture characterized by a strong Th1 and cytotoxic orientation that confers the lowest risk of death. Furthermore, our findings highlight the pivotal function of TLS in shaping the immune character of the tumor microenvironment, in promoting a protective immune response mediated by T cells against cancer. <i>Cancer Res; 74(3); 705–15. ©2013 AACR</i>.</p></div>
Evaluating the Impact of Information Technology on Knowledge Management Performance with Balance Scorecard Approach

Field: Business, Management and Accounting (Social Sciences)

Knowledge is one of the key factors of success and development in today's Firms. Therefore, managers are strongly fascinated by organizational knowledge management issues. In this way, information technology (IT) is known as an enabler of knowledge management (KM). In this paper, the impact of IT on knowledge management is evaluated with the balance scorecard approach considering financial, customers, internal processes and learning criteria. A conceptual model is presented for this purpose using IT application and infrastructure factors. The significant positive effect of the infrastructure factor on KM was 0.7 and that of the application was 0.79. The final result indicated a significant direct relationship between IT and KM that was 0.78, confirming the effect of IT on KM.
News and myth – dengue fever

Field: Health Professions (Health Sciences)

This project sets out to explore the possibilities of leveraging technology to assist in dengue prevention as well as increase awareness of the uninformed public of the dangers of mosquitoes, the diseases they transmit and news of outbreaks. In Sri Lanka, the general public is not adequately aware of the dangers mosquitoes bring into their lives. This project firstly introduces a prototype news feed which can be quickly customized in any programming language to suit the target location and audience by making use of Google’s news API. This prototype is targeted at bringing breaking news of dengue outbreaks but can be easily adapted for other diseases. In Western Europe, dengue fever has been spreading within countries which just a few decades ago had no incidence of said disease. This project attempts to explain and model the phenomenon with mathematical models in collaboration with a group of researchers. The hypothesis is that dengue is spread into European countries by air travel of infected passengers from dengue endemic countries. This project assists in the large number of calculations as well as the map creation process to better predict and visualize the spikes in dengue cases resulting from air travel importations. Finally, this project also prototypes a desktop app aimed at the non-technical user to quickly model and generate high quality maps based on importation of endemic, contagious diseases via air travel.
Childhood immunization, homeopathy and community nurses

Field: Health Professions (Health Sciences)

The way for community nurse practitioners to promote medical childhood immunization to parents, is for them to become fully conversant with both alternative and traditional medical approaches to this issue. A brief overview of homoeopathy and its approaches to immunization is outlined highlighting the current debate for and against anti-medical and medical immunization. Arguments are put forward supporting medical immunization and the challenges this presents for nurses practitioners.
Discourse and Real-Life Roles in the ESL Classroom

Field: Arts and Humanities (Social Sciences)

One of the most serious proposals for ESL curriculum reform to emerge within recent years is the functional-notional syllabus (see, for example, Wilkins 1976). An independent co-development is an innovative classroom technique based on group dynamics (see Curran 1976). As promising as these two innovations are, neither provides the background for understanding how language and culture are associated with the many roles which learners must play in real-life interactions. This article therefore proposes a taxonomy for role-types. Roles function in either long-term or short-term interactions and are thus either [—episodic] or [+episodic]. Three types of roles are established and illustrated via dialogs: social, emotive and maturational. Through a multidimensional model of discourse, interfactional exercises can be developed to lead ESL/EFL students to play roles in simulated natural settings while acquiring knowledge of the grammatical structure of English.
Lesson observation and feedback: The practice of an expert reading coach

Field: Social Sciences (Social Sciences)

Abstract This study investigated the practice of an expert reading coach as she provided lesson observation and feedback to an experienced kindergarten teacher. Data sources for the study included three cycles of observation of coaching sessions and guided reading instruction, as well as interviews. The report describes (a) the coach's modeling of pedagogical reasoning for the teacher and the co‐constructed nature of the coaching session interaction, and (b) specific ways in which the coach expanded her understanding of learning to teach and learning to coach. The study concluded that the technical aspects of lesson observation and feedback require many areas of expertise, developed through time spent coaching, training and reflection, and the coach's maintenance of an expert stance within coaching relationships.
[Trans-splicing of Cys mutated coagulation factor VIII].

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

To investigate the improving effect of inter-chain disulfide formation on protein trans-splicing, we introduce a Cys point mutation at Tyr(664) in heavy chain and at Thr(1826) in light chain of B-domain-deleted FVIII (BDD-FVIII). By co-transfection of COS-7 cell with the two Cys mutated chain genes, the intracellular protein splicing, inter-chain disulfide formation, secreted BDD-FVIII and bioactivity in culture supernatant were observed. The data showed that a strengthened spliced BDD-FVIII with an inter-chain disulfide detected by Western blotting and an elevated secretion of spliced BDD-FVIII (128 +/- 24 ng mL(-1)) compared to control (89 +/- 15 ng mL(-1)), assayed by a sandwich ELISA. A Coatest was performed to assay the secretion of bioactivity in culture supernatant and shown a much higher value (0.94 +/- 0.08 u mL(-1)) compared to that of control (0.62 +/- 0.15 u mL(-1)). It suggests that inter-chain disulfide formation could improve protein trans-splicing based dual-vector delivery of BDD-FVIII gene providing experimental evidence for ongoing in vivo study.
TRANSNATIONAL CRIMES IN SOUTHERN AND CENTRAL AFRICA: SELECTED COUNTRIES

Field: Social Sciences (Social Sciences)

This report considers the current trends in the field of transnational criminal law in selected countries in Southern and Central Africa and how the region has dealt with them. For the purposes of this report Southern and Central Africa include Angola, Botswana, Central African Republic, Democratic Republic of Congo, Eswatini, Lesotho, Malawi, Mozambique, Namibia, South Africa, Zambia and Zimbabwe. However, the report focuses on selected countries within the identified region, particularly, Angola, Botswana and Zambia.
The effect of metal oxide coating of urea on mineralization in two contrasting soils

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Urease inhibitors are used to delay the conversion of N supplied to soil as urea to better match the mineral N supply to crop demand. Using soil in petri dishes, we compared the spatial and temporal mineral N dynamics close to the site of urea addition for two soils of contrasting texture—sandy soil (2% clay) and clay soil (51% clay)—treated with N fertilizer products that had the potential to inhibit urease. The treatments included trace metal oxide coatings (ZnO, NiO, and CuO) of granular urea fertilizer, N ‐( n ‐butyl)thiophosphoric triamide (NBPT; a commercial urease inhibitor) coated urea and uncoated urea. In the sandy soil, NBPT inhibited urea hydrolysis, whereas the metal oxide–coated urea had little effect. Unlike in the sandy soil, the most striking result for the clay soil was the “disappearance” of mineral N in the latter part of the incubation. However, a delay in the disappearance of mineral N, hence a higher recovery, for the NBPT‐urea and CuO‐urea was observed at day 14 in the clay soil presumably due to the slower hydrolysis of urea compared to other treatments. Overall, the study of both spatial and temporal mineral N dynamics in soils supplied with urea fertilizers suggests that CuO‐coated urea could have properties that delay the hydrolysis of urea in certain soils. Given the strongly contrasting outcomes for the two soils, further experiments with soils that span the range of texture between these two extremes are warranted.
The Mentoring FAN: A Promising Approach to Enhancing Attunement within the Mentoring System

Field: Social Sciences (Social Sciences)

Youth mentoring is a popular tool in positive youth development, with most programs utilizing a model through which youth and non-parental adults are "matched." Using an adaptation of the Facilitating Attuned Interactions framework, this study sought to explore the effectiveness of the Mentoring FAN in enhancing interpersonal attunement among mentoring staff at two youth mentoring programs in the U.S. Upon completion of the Mentoring FAN training, quantitative (n = 28) and qualitative (n = 15) data were collected from program staff at both sites. Open-ended data from a subset of mentors (n = 27) was also gathered. Results revealed that mentoring staff experienced significant increases in empathy following the Mentoring FAN intervention. Participant interviews revealed increased attunement, increased listening ability, and increased collaboration in the supervisory relationship. Findings support the continued delivery and rigorous testing of Mentoring FAN training, with great promise for enhancing attunement across the mentoring system as a means of strengthening the relationships so critical to this intervention. The study also has important implications for the development of mentor support practices within mentoring organizations, as well as policies designed to meet the needs of youth served by mentoring programs in the U.S.
Expression and significance of Ku70 in serous ovarian tumors

Field: Medicine (Health Sciences)

Objective To explore expression and clinical significance of the Ku70 protein in serous ovarian tumors.Methods Expression of Ku70 was detected by SP immunohistochemistry in 20 specimens of normal ovarian tissues and 100 specimens of serous ovarian tumors(30 specimens of serous cystadenoma,20 specimens of borderline serous cystadenoma,and 50 specimens of serous cystadeno-carcinoma).The correlation of Ku70 expression and clinico-pathological characteristics of serous ovarian tumors was analyzed by the Chi-square test.Results Expression of Ku70 in borderline serous cystadenoma and serous cystadenocarcinoma was significantly higher than that in normal ovarian tissues and serous cystadenoma tissues(P0.01).Expression of Ku70 was more increased in lower-differentiated ovarian carcinoma,and it was related to FIGO stage,ascites and lymph node metastasis(P0.05).Conclusion High expression of Ku70 may be closely related to manifestation of serous ovarian tumors.
Chapter Nine The Vagina Monologues: Theoretical, Geopolitical, and Pedagogical Concerns

Field: Arts and Humanities (Social Sciences)

This essay explores the pedagogical possibilities and pitfalls inherent in using Eve Ensler’s The Vagina Monologues and its attendant antiviolence organization, VDay, as an example of transnational feminist antiviolence organizing and activism. While acknowledging the importance of the play and VDay in antiviolence fundraising efforts and in generating awareness of the global ubiquity of genderbased violence, I contend that the play, as well as the global antiviolence movement that has grown up around it, relies almost exclusively on U.S.based feminist epistemologies, subjectivities, and theoretical perspectives that are embedded within an American nationalist discourse1 that positions the United States as the “rescuer” of poor, brown women from the global South, who, as many feminist scholars have convincingly argued over the course of the last twenty years or so, are repeatedly depicted in American media—and by mainstream U.S. feminism—as a singular, powerless, and passive group (Mani, 1990; Mohanty, 1991; Narayan, 1997; Dell, 2002). This depiction has been reified and exaggerated since the days immediately following 9/11 when the Bush administration strategically (and successfully) justified the U.S. invasion of Afghanistan by arguing that the United States must “save” the women of Afghanistan from their (racialized, male) Muslim oppressors. I argue that U.S. feminism’s embeddedness in American nationalism affects how and why The Vagina Monologues is used, both formally and informally, as a pedagogical tool in U.S. women’s studies classrooms. I conclude that the play has the potential to serve as an
Return on Investment in Meetings and Events

Field: Business, Management and Accounting (Social Sciences)

The Phillips ROI Methodology™ utilizes five levels of evaluation, which are essential in determining the return on investment.At Level 1 - Reaction and Planned Action, attendee and stakeholder satisfaction from the meeting can be measured. Almost all organizations evaluate at Level 1, usually with a generic, end-of-meeting questionnaire. While this level of evaluation is important as a "stakeholder" satisfaction measure, a favorable reaction does not ensure that attendees have acquired new skills, knowledge, opinions or attitudes from the meeting. At Level 2 - Learning, measurements focus on what participants learned during the meeting using tests, skill practices, role-plays, simulations, group evaluations, and other assessment tools. A learning check is helpful to ensure that attendees have absorbed the meeting material or messages and know how to use or apply it properly. It is also important at this level to determine the quantity and quality of new professional contacts acquired and whether existing professional contacts were strengthened due to the meeting. However, a positive measure at this level is no guarantee that what was learned or whether the professional contacts acquired will be used on the job. At Level 3 - Job Applications, a variety of follow-up methods can be used to determine if attendees applied on the job what they learned or acquired at the meeting. The frequency and use of skills are important measures at Level 3. While Level 3 evaluations are important to gauge the success of the meeting, it still does not guarantee that there will be a positive business impact in the organization or for the attendee. At Level 4 - Business Results, the measurement focuses on the actual business results achieved by meeting participants as they successfully apply the meeting material or messages. Typical Level 4 measures include output, sales, quality, costs, time and customer satisfaction. Although the meeting may produce a measurable business impact, there is still a concern that the meeting may cost too much. At Level 5 - Return on Investment, this ultimate level of measurement compares the monetary benefits from the meeting with the fully-loaded meeting costs as expressed in the ROI formula. All levels of evaluation must be conducted in order to determine the ROI of a meeting or event. The data collected should show a chain of impact occurring through the levels as the skills and knowledge learned (Level 2) are applied on the job (Level 3) to produce business results (Level 4).
Genome-Scale Metabolic Network Reconstruction and In Silico Analysis of Hexanoic acid Producing Megasphaera elsdenii

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Hexanoic acid and its derivatives have been recently recognized as value-added materials and can be synthesized by several microbes. Of them, Megasphaera elsdenii has been considered as an interesting hexanoic acid producer because of its capability to utilize a variety of carbons sources. However, the cellular metabolism and physiology of M. elsdenii still remain uncharacterized. Therefore, in order to better understand hexanoic acid synthetic metabolism in M. elsdenii, we newly reconstructed its genome-scale metabolic model, iME375, which accounts for 375 genes, 521 reactions, and 443 metabolites. A constraint-based analysis was then employed to evaluate cell growth under various conditions. Subsequently, a flux ratio analysis was conducted to understand the mechanism of bifurcated hexanoic acid synthetic pathways, including the typical fatty acid synthetic pathway via acetyl-CoA and the TCA cycle in a counterclockwise direction through succinate. The resultant metabolic states showed that the highest hexanoic acid production could be achieved when the balanced fractional contribution via acetyl-CoA and succinate in reductive TCA cycle was formed in various cell growth rates. The highest hexanoic acid production was maintained in the most perturbed flux ratio, as phosphoenolpyruvate carboxykinase (pck) enables the bifurcated pathway to form consistent fluxes. Finally, organic acid consuming simulations suggested that succinate can increase both biomass formation and hexanoic acid production.
Web Simplification Prototype for Cognitive Disabled Users

Field: Computer Science (Physical Sciences)

Information and communication technology (ICT) and World Wide Web (WWW) are increasingly being used in daily life and becoming important in community, business, personal performance, and improvement of livelihood. people with disabilities (PWDs) can easily perform many tasks using WWW which might be difficult or impossible for them. However, many websites applications such as e-learning, e-commerce, and e-government are not specifically designed keeping in view PWD users. Through the web accessibility guidelines, web developers can build a web program accessible to PWDs. In this paper, we have investigated the issues related to website design that make it unavailable for PWDs. Keeping in view these issues, we have built a framework to make the web easier for PWDs. In addition, these issues are assessed using the GTmetrix, Netcraft, and WAVE accessibility tools and the results are generated using Google Analytics. Based on these results, we have proposed a simplified web version to improve website access for people with disabilities. The proposed prototype is also implemented on a website called Easywebcare by incorporating our recommendations for resolving the investigated issues. Analytics shows that the proposed type surpasses all existing activities in improving website accessibility for people with disabilities.
Combination Products: Drugs and Devices

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract Recent years have seen continued progress in development of new therapeutic products, such as implanted drug delivery systems and drug‐impregnated devices. The growth of new pharmaceutical products, especially since the expansion of drug research after 1945, has been possible due to synthesis and testing of millions of compounds. This article focuses on historical background, regulatory requirements, and future trends of delivery systems and drug‐impregnated devices.
Testing hypotheses about correlation matrices in general MANOVA designs

Field: Mathematics (Physical Sciences)

Correlation matrices are an essential tool for investigating the dependency structures of random vectors or comparing them. We introduce an approach for testing a variety of null hypotheses that can be formulated based upon the correlation matrix. Examples cover MANOVA-type hypothesis of equal correlation matrices as well as testing for special correlation structures such as sphericity. Apart from existing fourth moments, our approach requires no other assumptions, allowing applications in various settings. To improve the small sample performance, a bootstrap technique is proposed and theoretically justified. Based on this, we also present a procedure to simultaneously test the hypotheses of equal correlation and equal covariance matrices. The performance of all new test statistics is compared with existing procedures through extensive simulations.