jimnoneill/paper-to-field-training huggingface dataset:
Sarcoidosis with Granulomatous Hepatitis and Autoimmune Endocrine Involvement

Field: Medicine (Health Sciences)

Sarcoidosis is a systemic granulomatous disease of unknown aetiology.It emerges in the form of hiler adenopathy and interstitial pulmonary disease in most cases.The lungs, eyes, skin, abdominal organs, central nerve system and bones are among the organs involved. 1,2lthough non-caseous granulomas are detected histopathologically in the involvement of the liver in sarcoidosis, the values obtained from liver function test are generally normal.Hepatomegaly and retroperitoneal adenopathy are most frequently seen even though radiological evidence in sarcoidosis-related granulomatous hepatitis is rare. 2,3arcoidosis may also be related to endocrine autoimmune diseases.Autoimmune thyroiditis accompanying sarcoidosis has been reported in the literature; however, the combination of sarcoidosis with other autoimmune diseases is not frequent. 4,5utoimmune diseases such as type 1 diabetes mellitus (DM) and Hashimoto's thyroiditis, elevation of the liver function test values and granulomatous hepatitis with hepatomegaly were observed to accompany sarcoidosis in our case.To our knowledge, no other sample cases with all these components have been reported in the literature.A 50-year-old female patient complaining of backache and fatigue was admitted to our clinic due to elevation of liver function test values.The patient had undergone total abdominal hysterectomy and bilateral salpingooophorectomy 6 years prior to this presentation.She was diagnosed with type 1 diabetes mellitus 25 years ago and has had Hashimoto's thyroiditis, osteoporosis and fibromyalgia for 3 years.A high-resolution computed tomographic (CT) scan, obtained in February 2004 due to dyspnoea, revealed a ground-glass appearance in the lungs.Open lung biopsy was performed and the diagnosis of sarcoidosis was made.One-year methlyprednisolone therapy was started.She weighed 74 kg and her height was 1.7 m.Her blood pressure was 100/80 mmHg.The thyroid gland palpated heterogeneously.Incision scars of approximately 10 cm extending from the left anterior axillary line to the posterior axillary line and a median infra-umbilical incision of approximately 15 cm were noted.The liver was palpable approximately 5 cm below the costal margin.There were numerous subdermal nodules, and the biggest of which was 1 x 1 cm in the right upper and lower extremities.Laboratory investigations revealed the following -fasting glucose level: 228 mg/dL, total cholesterol: 279 mg/dL,
What's better than the pill, vasectomy, celibacy and rhythm?

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

A report of a new technique of male contraception involves the use of heat which lowers the sperm count. Early reports of lowered sperm counts in men wearing jockstraps or increased sperm counts in men whose testicles have been cooled several degrees have led to the experimentation in the male rat of the effects of heat and ultrasound on the sperm count and the ability to fertilize the female. 250 male rats were divided into 5 groups: 1) control, 2) a 60 degree C water circulating testicle cup with 15 minutes exposure, 3) exposure to radiant energy for 15 minutes and raising scrotal temperatures to 60 degrees C, 4) exposure to microwaves of varying powers, and 5) exposure to ultrasound of 1 w/cm to 2 w/cm for 1 minute. Group 2 results indicated that libido was uninhibited, testosterone levels undisturbed a nd organ sizes unaffected by the hot-water treatment. It took 30-35 days for any pregnancies to occur after a single treatment. In group 3, results were substantially the same except that it took 60-75 days for any pregnancies to occur. In group 4, a 20% exposure to radiation for 5 minutes impaired fertility for 65-80 days, while those exposed to 20% for 15 minutes were still infertile at the end of the 10-month study. In these cases libido was also unimpaired. Animals in group 5, exposed to 1 w/cm for 1 minute had impaired fertility for 150-210 days although testicular temperature rose to only 38 degrees C. When exposure to ultr asound was doubled, fertility was impaired throughout the study. In all cases where fertility was restored, resulting offspring appeared normal and were themselves capable of reproducing normal-appearing offspring. Ultrasound was considered the most promising heat source. In all cases the germinal epithelium function is arrested. Future research should be directed to making the ultrasound technique more finely tuned to a contraceptive function.
Electrochemical Formation of Bismuth Phosphate Nanorods by Anodization of Bismuth

Field: Materials Science (Physical Sciences)

We report on hexagonal-phase bismuth phosphate nanorods that can be formed on bismuth substrates by anodization in fluoride-containing concentrated phosphoric acid electrolyte. Under optimized conditions, layers can be formed that consist of rods with a diameter of 50–70 nm and a length of 250 nm. These nanorods are characterized by scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and photoluminescence measurements. The results confirm the presence of nanorods that show a high photoluminescence in the visible range of the spectrum, peaking at a wavelength of 440 nm.
A method for combined dacryocystorhinostomy with external ethmoidectomy

Field: Medicine (Health Sciences)

Abstract Severe polypoid rhinosinusitis requiring external ethmoid surgery may be seen in conjunction with partial or complete nasolacrimal obstruction. When this obstruction is associated with persistent, unresolved lacrimal symptoms, it is sometimes appropriate to combine surgical procedures, thereby avoiding separate lacrimal surgery. A method combining dacryocystorhinostomy (DCR) with external ethmoidectomy is described. The anatomy involved in this procedure and the indications for it are discussed.
Antibacterial Evaluation of Some 3-Amino-1H-Pyrazolo[1,2-b]Phthalazine-2-Carboxamides by using Fish Scale Hydroxyapatite as a Heterogeneous Catalyst

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Fish scale hydroxyapatite (FS-HAP) has been used as an efficient catalyst for the synthesis of 3-amino-1H-pyrazolo[1,2-b]phthalazine-2-carboxamide derivatives via the one-pot, three-component cyclocondensation reactions of aromatic aldehydes with cyanoacetamide and phthalhydrazide under solvent-free condition. FS-HAP has been characterized by FT-IR, XRD, SEM and EDS techniques. The synthesized compounds were evaluated for their in vitro antibacterial activity against gram-positive (Bacillus cereus, Bacillus aryabhattai, Bacillus megaterium, Staphylococcus aureus) and gram-negative (Serratia marcescens, Bacillus Pseudomonas putida, Escherichia coli, Enterobacter cloacae) bacteria. Tetracycline and erythromycin were used as standard antibiotics in this investigation. In the present protocol, we have achieved remarkable yields of the product in shorter reaction time and the catalyst was easily recovered and reused.
Long non-coding RNA HLA-F antisense RNA 1 inhibits the maturation of microRNA-613 in polycystic ovary syndrome to promote ovarian granulosa cell proliferation and inhibit cell apoptosis

Field: Medicine (Health Sciences)

MicroRNA-613 (miR-613) inhibits granulosa cell proliferation, suggesting its involvement in polycystic ovary syndrome (PCOS). We predicted that long non-coding RNA (lncRNA) HLA-F antisense RNA 1 (HLA-F-AS1) could interact with premature miR-613. We then explored the crosstalk between HLA-F-AS1 and miR-613 in PCOS. In this study, follicular fluid donated by 58 healthy controls and 58 PCOS patients was used to analyze the expression of HLA-F-AS1 and miR-613 (mature and premature). The direct interaction between HLA-F-AS1 and premature miR-613 was evaluated by RNA pull-down assay. Overexpression of both HLA-F-AS1 and miR-613 was achieved in granulosa cells to assess their interactions. Cell proliferation and apoptosis were detected with BrdU assay and cell apoptosis assay, respectively. We found that miR-613 was highly expressed in PCOS, while HLA-F-AS1 was downregulated in PCOS. HLA-F-AS1 directly interacted with premature miR-613, and overexpression of HLA-F-AS1 increased the expression levels of premature miR-613, but decreased the expression levels of mature miR-613. HLA-F-AS1 increased ovarian granulosa cell proliferation and inhibited cell apoptosis. MiR-613 played an opposite role and suppressed the role of HLA-F-AS1. Therefore, HLA-F-AS1 may inhibit the maturation of miR-613 in PCOS to promote ovarian granulosa cell proliferation and inhibit cell apoptosis.
Emerging research on characterizing the potential of cable bacteria for CH4 mitigation

Field: Environmental Science (Physical Sciences)

Methane (CH4) contributes an essential portion for global warming as a pivotal greenhouse gas. Microorganisms are identified as an effective way to mediate and control CH4 emission. Cable bacteria is a promising microorganism to mitigate CH4, however, the studies of distribution, abundance and function for CH4 reduction of cable bacteria in inland water still remain unclear. In this paper, we propose the probable CH4 mitigation metabolism within cable bacteria in anoxic condition, and present the future research directions about the application potential of cable bacteria in CH4 reduction. The viewpoint will help to understand the significant role of cable bacteria in CH4 mitigation and provide a potential way to control CH4 emissions in inland freshwater ecosystem.
Somatosensory Function and Gait Biomechanics In Individuals With Anterior Cruciate Ligament Reconstruction

Field: Medicine (Health Sciences)

Somatosensory function of the knee is reportedly altered following anterior cruciate ligament reconstruction (ACLR), potentially influencing the risk of osteoarthritis (OA). Poorer somatosensory function is associated with aberrant gait biomechanics in individuals diagnosed with knee OA, but this relationship has not been evaluated following ACLR. PURPOSE: To compare somatosensory function between limbs in individuals with ACLR and evaluate associations between somatosensory function of the ACLR limb and gait biomechanics. METHODS: Sixty-eight individuals with unilateral ACLR (72% females; age 21 ± 3 yr; time since ACLR 27 ± 15 mo) volunteered. Somatosensory function was assessed bilaterally as the ability to replicate a specified knee flexion angle during a joint position sense task (i.e. joint position sense error – JPSE). Gait outcomes were assessed during the first 50% of stance including vertical ground reaction force (vGRF), instantaneous loading rate, internal extension moment, and internal valgus moment. RESULTS: There was no difference in JPSE between the ACLR limb and the contralateral limb (2.9 ± 1.2° vs 2.8 ± 1.7°, p = 0.71). Additionally, there was no correlation between the ACLR limb JPSE and vGRF (r = -0.095, p = 0.44), instantaneous loading rate (r = -0.121, p = 0.33), internal extension moment (r = -0.018, p = 0.88), or internal valgus moment (r = -0.073, p = 0.55). CONCLUSIONS: JPSE did not differ between the ACLR and contralateral limbs, and JPSE in the ACLR limb was not associated with gait biomechanics. The mean time since ACLR in our sample was approximately 2 years, thus somatosensory adaptations may have occurred bilaterally at time of testing. Moreover, neuromuscular function of the contralateral limb is also influenced by ACLR, potentially confounding a comparasion of JPSE between limbs that may have both undergone changes post-operatively. These findings suggest the need to compare somatosensory function to a healthy cohort. Furthermore, the small magnitude and limited variability of JPSE likely minimized its ability to predict gait outcomes. Future research is necessary to determine whether somatosensory deficits emerge at later time points post-ACLR compared to a healthy cohort and if they influence knee OA risk.
A global climate model study of CH4 emissions during the Holocene and glacial‐interglacial transitions constrained by ice core data

Field: Environmental Science (Physical Sciences)

Ice core records show atmospheric methane mixing ratio and interpolar gradient varying with climate. Changes in wetland sources have been implicated as the basis for this observed variation in the record, but more recently, modeling studies suggest that changes in the CH 4 sink resulting from changes in sea surface temperature (SST) and emissions of other volatile organic carbon (VOC) compounds by vegetation must also be considered. We use the Goddard Institute for Space Studies (GISS) General Circulation Model (GCM) with the GISS Tropospheric Chemistry Model to study the response of the methane mixing ratio to source changes during the Holocene and also to a changing chemical sink during glacial‐interglacial transitions. We combine model results with ice core data to demonstrate a method that provides constraints on changes in northern and tropical methane sources. Results show that within the Holocene, changes in the atmospheric methane mixing ratio and latitudinal gradient are not linear with respect to changing methane emissions. Tropical and northern emissions varied from preindustrial levels by as much as 38% and 15%, respectively, within the Holocene. At glacial‐interglacial transitions the methane mixing ratio is sensitive to changes in both VOC and tropical methane emissions and the sensitivity also depends strongly on the assumed SST shift. Our findings suggest that changes in the ice core methane record are likely the result of changes in both the source and the sink. Changes in the sink become especially important when changes in methane mixing ratio and/or climate are large.
Factors influencing placental and fetal development in the mare: important considerations for the selection of embryo recipients

Field: Veterinary (Health Sciences)

In mammals the placenta is the vehicle for nutritional and gaseous exchange between the maternal and fetal circulations during pregnancy. The allantochorionic placenta of equids is classified as non–deciduate, non–invasive, epitheliochorial and diffuse and, as such, equine placentation demands fetomaternal interdigitation over the entire endometrial surface to optimise fetal development in utero . Any shortcomings are reflected by slower growth and delayed maturation of the fetus. This requirement for an unabbreviated area of placental attachment is emphasised by the inability of mares to carry twin conceptuses to term due to simple competition between the two placentae for the limited area of endometrium which results in progressive starvation of one or both fetuses (Jeffcott and Whitwell, 1973). In addition, age–related chronic degenerative changes in the mare's endometrium (endometrosis) may compromise the uterine environment during pregnancy and Bracher et al . (1996) showed a close relationship between the health of the endometrium, the normality of structure and the density of the microcotyledons on the surface of the allantochorion, and fetal weight.
Insights Into the Pathophysiology of Endocannabinoid Signaling in Schizophrenia

Field: Neuroscience (Life Sciences)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
III.7 — X-ray free-electron-lasers

Field: Physics and Astronomy (Physical Sciences)

X-ray free-electron laser (FEL) facilities are unique tools providing extremely brilliant X-rays that allow the observation of matter on the scale of atomic processes. In this chapter we will qualitatively explain some fundamental concepts related to undulator and FEL radiation and we will describe the X-ray FEL facilities, including the typical layout, some basic concepts about electron beam dynamics and properties, and current facilities.
G1300-1-5 Mechanical characteristics of CFRP molded by new hand layup method

Field: Engineering (Physical Sciences)

In this work, the mechanical characteristics of CFRP molded by new hand lay-up method using epoxy resin is investigated. Three types of CFRP; autoclave molding method, conventional hand lay -up method, the new one, were prepared and compared in tensile test and bending test. The maximum stress of the new method CFRP in tensile test was 30% lower than autoclave one, but not less than conventional hand lay -up method. In bending test, the new CFRP shows 60% larger maximum tensile stress than conventional method and was comparable to autoclaved CFRP. The delamination of CFRP might have effect to maximum stresses.
Auxiliary Hypotheses about Domestic Politics and Trade Agreements

Field: Economics, Econometrics and Finance (Social Sciences)

This chapter examines three auxiliary hypotheses that flow from the main argument. First, in countries with more veto players it is less likely that political leaders will be able to form deeper integration agreements. As trade agreements become more constraining, they will prompt greater resistance from more groups. Hence, countries marked by a large number of veto players are unlikely to accede to agreements that aim to achieve more extensive integration. Second, in the same vein, political leaders are also unlikely to enter preferential trading arrangements that include more constraints, such as a dispute settlement mechanism. Finally, in countries with more veto players, we expect greater delays between signing and ratifying agreements. As the number of veto players rises, so does the time needed for the government to convince these groups of the agreement's value and to design ways of compensating those that will be harmed by it.
Remittances and Quality of Life of Emigrant Families in Kerala

Field: Social Sciences (Social Sciences)

International migration has an important role in the economic development of every economy.In Kerala, most of the people prefer to emigrate for skilled and unskilled labour to the developed countries to improve the living standards oftheir families.According to Kerala Migration Survey Report, forevery 100 households in the state, there were 29.3 emigrants in 2014and the number of emigrants has increased graduallyover the years, from13.6 lakhs in 1998 to 24.0 lakhs in 2014.Kerala is receiving an increasing amount of money from abroad as workersâ€™ remittances and total remittancesto Kerala in 2014 was estimated to be Rs71,142 crores.Remittances per household were Rs 86,843 in 2014 compared to Rs. 63,315 in 2011 and Rs. 57,227 in2008.The present study is to find out trend and growthof household remittance in Kerala and to analyze the impact of these remittance to the living standards of emigrant families.
Chemical Constituents, Antioxidant, Cyclooxygenase Inhibitor, and Cytotoxic Activities of Teucrium pruinosum Boiss. Essential Oil

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Introduction . In traditional medicine, many pharmacological activities have already been ascribed to the genus of Teucrium plant. These include antirheumatic antispasmodic, anthelmintic, diuretic, hypoglycemic, and anticancer effects. The recent investigation aimed to characterize and estimate the chemical composition, anti-inflammatory, antioxidant, and anticancer potentials of the essential oil isolated by the microwave-ultrasonic apparatus from Teucrium pruinosum leaves collected from Palestine. Methods . The essential oil (EO) was analyzed by Gas Chromatography equipped with mass spectrometry (GC-MS), while its anticancer activity was evaluated against HeLa cervical adenocarcinoma cells. The ability of T. pruinosum EO to inhibit the conversion of Arachidonic Acid (AA) to PGH 2 by ovine COX-1 and human recombinant COX-2 was determined using a COX inhibitor screening assay. In addition, the antioxidant activity of the EO was evaluated on the basis of the scavenging activity with a stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, while Trolox was used as a positive control. Results . Forty-four molecules were identified in T. pruinosum EO, representing 100% of the total EO. Agarospirol was found to be the most abundant component (45.53%) followed by caryophyllene (19.35%). However, the cyclooxygenase inhibitor assay revealed that T. pruinosum has potential COX-1 and Cox-2 inhibitory activity with IC 50 values of 0.25 µ g/ml and 0.5 µ g/ml, respectively. Moreover, the T. pruinosum EO showed moderate antioxidant capacity with an IC 50 value of 16.98±0.84 µ g/ml in comparison with the positive control Trolox, which has an antioxidant potential with an IC 50 value of 2.09±0.17 µ g/ml. In addition, 250, 125, 62.5, 31.25, 15.625, 7.67, and 3.84 mg/ml of T. pruinosum EO treatments inhibited mitochondrial activity (cell viability) significantly and extremely by 90-95%. Conclusion . The current study provided data that revealed that the T. pruinosum EO could be a suitable candidate for use as a novel anticancer, anti-inflammatory, and antioxidant medication. Further clinical trials would be required to ensure these effects and to allow the design of suitable pharmaceutical dosage forms from this natural oil.
The reason why KAPF went to another country － KAPF’s media strategy as seen through children’s magazine 『BYEOLNARA』

Field: Arts and Humanities (Social Sciences)

다양한 매체의 형성은 프로문학의 전개에도 영향을 주었다. 그러나 정작 국내에서 카프가 기관지 형식의 매체를 운용하지 못했던 현상에서 본 연구의 문제 인식은 시작되었다.BR 1920년대 후반 김기진의 대중화론 논의에서 촉발된 카프의 매체 활동은 조선어 출판자본과의 결합도 마다하지 않았다. 또한 일제 당국의 검열에 대해서도 타협할 수 있다는 입장으로 대중매체의 장을 지키려 했다. 카프 기관지로 기획된 『문예운동』 창간을 그 노력의 첫 수확이라고 평했던 것과 달리 지속적인 운용으로 이어지지 못하며 카프의 매체 전략은 다시 한 번 좌절을 맞게 된다. 카프는 동경지부가 주축이 되어 일련의 성과를 냈으나 국내에서 지속적으로 주도하는 매체가 부재했던 것이다.BR 그럼에도 카프 맹원 임화는 실천적 예술 활동을 펼칠 매체에 대한 의지가 절박했던 것으로 보인다. 그를 주축으로 한 카프가 다름 아닌 아동잡지 『별나라』로 향한 것은 어떤 까닭일까. 카프는 초창기 『별나라』를 계급의식을 이식할 대상으로 인식했던 것으로 보인다. 이는 계급투쟁기에 접어들며 정체기를 맞은 카프가 전환적으로 시도한 매체투쟁의 일환이었다. 카프와 『별나라』의 교섭은 조직 재정비기를 맞은 카프가 위기를 극복할 계기가 되었다. 실제로 『별나라』는 계급주의의 목적성이 뚜렷한 글들이 다수 게재하였다. 또한 나프(NAPF)를 비롯한 각 나라의 계급문학의 흔적이 발견된다. 이는 『별나라』를 범세계적 차원의 투쟁이 실현되는 매체로 운용하고자 했던 카프의 의지로 읽을 수 있다. 요컨대 『별나라』는 카프가 문화 대중화 차원에서 긴밀하게 기획한 매체 전략의 장이었던 것이다. 대중화 전략의 하나였던 연령 분화를 목적으로 한 활동에 아동잡지의 기획은 필수적인 과정이었다.BR 그럼에도 『별나라』를 향한 카프의 목적의식은 성취와 좌절의 길항 속에서 존재했다. 10년 가까이 지속되어 온 『별나라』의 성격을 일면적으로 규정하는 것 역시 무리가 있다. 􋺷별나라􋺸의 다양한 매체적 성격 구명을 통해 식민지 아동 잡지의 새로운 구도를 모색해야 할 필요성이 존재하는 까닭이다.