jimnoneill/paper-to-field-training huggingface dataset:
Influence of dexamethasone on peripheral metabolic parameters of cortisol in the adult male conscious guinea-pig.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The influence of dexamethasone on distribution, metabolism and protein binding of cortisol was studied in conscious adult male guinea-pigs, under chronic cannulation, by a single injection technique for cortisol metabolic parameters and Sephadex equilibrium dialysis procedure for protein binding. The results showed that biological half-life of cortisol (51-55 min) was identical in control and in dexamethasone-treated guinea-pigs (low plasma cortisol level). The apparent volume of distribution of cortisol, which was higher in control (550 +/- 20 ml) than in dexamethasone-treated animals (380 +/- 30 ml), was related to the higher plasma cortisol level in controls (0.96 +/- 0.07 mumole/l) as compared to dexamethasone-treated animals (0.12 +/- 0.02 mole/l). When a high cortisol concentration was infused in dexamethasone-treated guinea-pigs in order to produce hig plasma cortisol level, plasma cortisol MCR increased by 80% (P less than 0.001) reflecting increases of 50% (P less than 0.001) in the apparent volume of distribution and decreases of 19% (0.01 less than P less 0.02) in the half-life cortisol compared to dexamethasone-treated animals (low plasma cortisol level). Although the plasma cortisol level was higher (P less than 0.001) in dexamethasone-treated animals infused with non-labelled cortisol (2.9 +/- 0.02 mumol/l) than in controls (0.96 +/- 0.07 mumol/l), the identical values of the apparent volume of distribution in dexamethasone-treated animals infused with non-labelled cortisol and in controls suggested that dexamethasone could alter the distribution of cortisol, and therefore its metabolism. Dexamethasone did not modify the transcortin-binding capacity and did not complete with cortisol on transcortin sites in guinea-pig plasma.
Effect of serum lipoproteins on the adenylate cyclase activity of rat liver plasma membranes

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Four rat lipoprotein classes [lymph chylomicrons, VLD (very-low-density), LD (low-density) and HD (high-density) lipoproteins] were tested for their ability to affect basal adenylate cyclase (EC 4.6.1.1) activity of rat liver plasma membranes. All the lipoproteins, with the exception of lymph chylomicrons, effectively increase the enzyme activity. VLD lipoproteins are the most active class (67% maximal increase), followed by HD lipoproteins (33%) and LD lipoproteins (23%). The effect of VLD lipoproteins is additive to that elicited by GTP or GTP plus glucagon (at least within a certain concentration range). VLD lipoproteins affect only the Vmax. of the enzyme, not the Km.
Bayesian estimation for target tracking: part II, the Gaussian sigma‐point Kalman filters

Field: Mathematics (Physical Sciences)

Abstract This is the second part of a three part article examining methods for Bayesian estimation and tracking. In the first part we presented the general theory of Bayesian estimation where we showed that Bayesian estimation methods can be divided into two very general classes: a class where the observation conditioned posterior densities are propagated in time through a predictor/corrector method; and a second class where the first two moments are propagated in time, with state and observation moment prediction steps followed by state moment update steps that use the latest observations. In this second part, we make the assumption that all densities are Gaussian and, after applying an affine transformation and approximating all nonlinear functions by interpolating polynomials, we recover the sigma‐point class of Kalman filters, including the unscented, spherical simplex, and Gauss‐Hermite Kalman filters. In part 3, we will show that approximating a density by a set of Monte Carlo samples leads to particle filter methods, where the posterior density is propagated in time and moment integrals are approximated by sample moments. WIREs Comput Stat 2012 doi: 10.1002/wics.1215 This article is categorized under: Statistical and Graphical Methods of Data Analysis > Bayesian Methods and Theory
Delay-line stabilized microwave oscillator with frequency control

Field: Engineering (Physical Sciences)

The technique whereby the frequency of an oscillator is stabilized using an external feedback network incorporating a delay-line is extended in this thesis to provide digital control of the frequency of the oscillator. Novel circuit techniques have been developed and analysed to permit the implementation of the proposed frequency control technique in a compact format, suitable for implementation in either hybrid or monolithic microwave integrated circuits. Two new microstrip circuits have been introduced, namely the three-port ring discriminator and the single PIN diode phase shifter. Frequency control of an oscillator is achieved by digitally controlling the time delay through phase shifters in the feedback path of the oscillator&apos;s sta-bilization circuit. A new microstrip phase shifting circuit has been developed
Comments on Sports Participation and Transgender Youths—Reply

Field: Medicine (Health Sciences)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Additional file 4: Table S3. of Human newborn bacille Calmetteâ GuĂŠrin vaccination and risk of tuberculosis disease: a case-control study

Field: Medicine (Health Sciences)

Genes differentially expressed between cluster 1 and cluster 2 infants from the secondary cohort. Gene expression was calculated by subtracting expression in PBMC incubated with medium alone from expression in PBMC incubated with BCG. (XLSX 358 kb)
Loneliness and Lament

Field: Arts and Humanities (Social Sciences)

Huntington (philosophy and religious studies, New College of Interdisciplinary Arts, Arizona State Univ.) endeavors to describe the emotional growth of women through the life span. Calling on Jungian and biblical studies, the author is particularly interested in describing the challenges women have in coping with loss. The book is likely to appeal to a segment of the reading population interested in nondenominational, spiritual reading. That a 'commentary on sources' substitutes for a bibliography is an indicator of the personal writing style.... Summing Up: Optional. General readers; professionals. - Choice
P1‐127: Voxel‐based morphometry study of gray matter abnormalities in neurodegenerative disease with obsessive‐compulsive behaviors

Field: Neuroscience (Life Sciences)

Obsessive-compulsive disorder (OCD) is a disabling psychiatric disorder characterized by intrusive thoughts and ritualistic behaviors. The pathophysiology of OCD is thought to involve disturbance of the frontal-subcortical circuitry. OCD symptoms has not yet to be directly studies in the neurodegenerative conditions involving behavior changes. To examine regional abnormalities in the brains of dementia patients with OCD symptoms, we assessed the gray matter density using voxel-based morphometry (VBM). A total of 106 patients diagnosed with one of six neurodegenerative diseases were recruited into the study from the University of California San Francisco Memory and Aging Center. Criteria for including patients were a diagnosis of dementia, the availability of modified Manchester Behavior Questionnaire (MBQ) data and a high quality research MRI scan within 6 months of the modified MBQ assessment. OCD behaviors were assessed using modified MBQ. Covariates-only statistical models were used to show the relationship between OCD symptom scores and gray matter volume. The total OCD symptom score correlated negatively with the volume of both putamen, right middle orbitofrontal gyrus, both anterior cingulate, left insula (p<0.001, uncorrected). No gray matter reductions were associated specifically with the OCD symptom sub-categories. To explore which part of the OCD circuit identified in our results were contributed predominantly by a single diagnostic group, we evaluated unique brain regions associated with OCD total score according to the dementia subtype. Alzheimer's disease and FTLD including FTD, semantic dementia, primary progressive aphasia did not show unique regions associated with OCD total score (p<0.001, uncorrected). At an uncorrected significance threshold (p<0.001), no gray matter reductions were associated specifically with the OCD behavior sub-categories. Our findings show that the right orbitofrontal, both putamen, both anterior cingulate, and left insula are regions associated with OCD symptoms in dementia patients, but distinct gray matter abnormalities are not associated with the symptom dimensions of OCD. Our results suggest that abnormalities in these area may play an important role in the pathophysiology of OCD in neurodegenerative disease. Further research is necessary to verify neuroanatomic mechanisms for OCD symptoms in patients with neurodegenerative disease.
Antietam: aspects of medicine, nursing and the civil war.

Field: Medicine (Health Sciences)

Robert E. Lee's Army of Northern Virginia met the Army of the Potomac under George B. McClellan at Antietam Creek near Sharpsburg, Maryland on September 17, 1862. Before the day was done, nearly 23,000 men were killed, wounded, or missing, memorializing Antietam as the bloodiest single day in American military history. Dr. Jonathan Letterman, the Medical Director of the Army of the Potomac, Clara Barton, the "Angel of the Battlefield," and Dr. Hunter McGuire, Chief Surgeon to and Medical Director of General Stonewall Jackson's Corps, were among the nursing and medical personnel engaged on that historic day. These three individuals provided medical and nursing care to the casualties at Antietam (and other Civil War battles), but perhaps more importantly, developed systems of casualty management that brought order and humanity to the battlefield. These models of care continue today in modern military medicine.
Spiritual Journalism in India: A Critical Review

Field: Arts and Humanities (Social Sciences)

This research paper aims to critically review the state of spiritual journalism in India. Spiritual journalism is a niche form of journalism that focuses on exploring and reporting on spiritual and religious topics, practices, and perspectives. In India, a country with a rich spiritual heritage and diverse religious traditions, spiritual journalism plays a significant role in shaping public discourse and understanding of spirituality. This paper examines the strengths and weaknesses of spiritual journalism in India, exploring its impact on society, its challenges, and the ethical considerations associated with its practice. By providing a critical analysis of the current state of spiritual journalism in India, this paper aims to shed light on its role, relevance, and potential for improvement.
The first affiliated hospital of Kunming medical university 2011 surveillance of antimicrobial resistance in Acinetobacter baum-annii

Field: Medicine (Health Sciences)

Objective To investigate the antimicrobial resistance of A. baumann-ii isolated from patients in our hospital during 2011. Methods Clinical isolates of A. b-aumannii were collected from our hospital. The results of drug susceptibility test were analyzed. Result Of the 3878 clinical strains were collected,A. baumannii was 359(9. 2%) ,and 78. 8% were isolated from respiratory tract. The resistance,of A. baumannii to 16 antimicrobial agents of 2011,showed downward trend. The percenttage of the A. baumannii isolates resistant to 16 ntimicrobial agents was generally above50% ,but the cefoperazone / sulbactam was 3% ,the Ceftazidime was 33% . The resistance of imipen-em was 54% and meropenem was 52% . 2011,the panresistant(only sensitive to colistin) A. baumannii strains accounted for 16. 6. But,2010,it was 6. 4% . Conclusion The ant-imicrobial resistance of A. baumannii is still a serious problem in our hospital. The sur-veillance of antimicrobial resistance is very important for guiding rational antimicr-obial therapy in healthcare facilities.
EFFECT OF SUBSTRATE CONCENTRATION AND FeCl2 ADDITION ON L-ASPARAGINASE ACTIVITIES OF BACTERIA SYMBIONTS BROWN ALGAE Sargassum sp. AND ITS POTENTIAL AS A NEW ANTI-DENGUE AGENTS

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The disintegration of the amide link, causing L-Asparaginase catalyzes the hydrolysis process of L-Asparagine into ammonia and aspartic acid. The purposes of this study were to determine the optimal conditions for enzyme production and enzymatic activity, including their potential as a new anti-dengue of L-asparaginase from Klebsiella sp. The Nessler method used a UV-Visible spectrophotometer to determine the L-asparaginase activity by measuring ammonia levels produced by L-asparaginase catalysis. The ideal fermentation period was at the 48th hour, and the optimal substrate concentration was 10 g/L with an activity value of 49.572 U/mL, and the optimal FeCl2 concentration was 0.5 g/L with an activity value of 60.1183 U/mL, and protein content of 0.1878 mg/mL. The optimum conditions for L-asparaginase, which has an activity value of 61.1182 U/mL, were observed at pH 8 and 37 °C. The optimum cofactor concentration of FeCl2 was 0.5 mM, which resulted in an activity value of 106.5046 U/mL. Both the inhibition percentage and CC50 value were 80% and 167.15 μg/mL respectively, showing that the L-asparaginase has a high antidengue potential.
Sensitivity Levels of Green Leafhopper (GLH) Populations to Insecticides At IRRI in 1983-84

Field: Agricultural and Biological Sciences (Life Sciences)

This article 'Sensitivity Levels of Green Leafhopper (GLH) Populations to Insecticides At IRRI in 1983-84' appeared in the International Rice Research Newsletter series, created by the International Rice Research Institute (IRRI). The primary objective of this publication was to expedite communication among scientists concerned with the development of improved technology for rice and for rice based cropping systems. This publication will report what scientists are doing to increase the production of rice in as much as this crop feeds the most densely populated and land scarce nations in the world.
FLUORESCEIN IN HUMAN PLASMA IN VIVO

Field: Medicine (Health Sciences)

In connection with corpus vitreum fluorophotometric examinations fluorescein was injected iv and fluorescein in the blood stream was studied with respect to protein binding and elimination kinetics. It was shown by ultrafiltration that in blood obtained during the examination most of the fluorescein was protein bound, and only a minor fraction (10–20%) was free in the water phase. While the free fraction was approximately constant over a wide concentration range when studied in vitro the free fraction increased by a factor of about 2 during a 2 h examination period in vivo. The curve describing the elimination of fluorescein from blood showed a polyexponential decline course. The area under this curve showed only a small variation for the same normal person examined 3 times over a period of 6 months. The area under the bolus has a magnitude, which is 30–40% of that under the rest of the curve.
Task Effects on the Spontaneous Activation of Trait Concepts

Field: Psychology (Social Sciences)

The present study examined whether readers' processing goals affect the spontaneous generation of dispositional trait inferences. In Experiment 1, a constrained word stem completion task was used to detect trait activation when subjects read paragraphs that described the actions of a central character. Subjects were oriented to one of four processing goals: verbatim recall, factual recall, general elaborative recall, or impression formation. Evidence for the spontaneous activation of trait inferences was found only when processing demands required some form of elaborative processing (general elaboration and impression formation). In Experiment 2, we tested whether implicit memory tasks such as word stem and word fragment completion actually measure on-line concept activation, as we and other investigators have assumed. We found that both the word stem completion task and a word fragment completion task are sensitive to which concepts are activated during sentence comprehension. However, the word stem task was superior to the fragment task in detecting priming. Overall, the results support a multi-stage view of dispositional inferences.
In vitro differentiation and proliferation of human hematopoietic progenitors: the effects of interleukins 1 and 6 are indirectly mediated by production of granulocyte-macrophage colony-stimulating factor and interleukin 3.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The effect of recombinant human interleukin (IL)-1 and IL-6 on the differentiation and proliferation in vitro of human granulocyte-macrophage (GM) and erythroid progenitors has been investigated in either fetal bovine serum (FBS)-supplemented or FBS-deprived cultures. Sources of progenitor cells were unfractionated bone marrow cells or marrow cells depleted of adherent and/or T cells. Each interleukin was investigated either alone or in combination with GM-colony-stimulating factor (CSF), IL-3 and erythropoietin (Epo), or granulocyte (G)-CSF. In FBS-supplemented cultures of unfractionated marrow cells, IL-1 induced optimal GM colony growth and increased by 50% the number of erythroid bursts that formed in the presence of Epo. The addition to these cultures of a neutralizing anti-GM-CSF monoclonal antibody or of an anti-IL-3 serum decreased the growth of GM colonies by 80% and 40%, respectively. Under the same conditions, IL-6 had no effect on GM colony growth but increased by 90% the number of erythroid bursts. This effect was partially (40%) neutralized by addition of anti-IL-3 serum. IL-1 and IL-6 were weak stimuli, or had no effect at all, either alone or in combination with GM-CSF and IL-3 in FBS-deprived cultures or in FBS-supplemented cultures of nonadherent or nonadherent, T-cell-depleted marrow cells. IL-1 and IL-6 had no effect, either alone or in combination with IL-3, in maintaining the number of progenitor cells in short-term liquid suspension cultures. These results indicate that the actions of IL-1 and IL-6 on hematopoiesis are mainly indirect and mediated by the production of GM-CSF and/or IL-3 by accessory cells. However, neither IL-1 nor IL-6 alone is sufficient to stimulate production of growth factor(s) by accessory cells, and at least a second stimulus, provided by FBS, is also required. These data are in agreement with a multisignal model of regulation of the expression of growth factor genes.
Grounded Theory as an Approach for Exploring the Effect of Cultural Memory on Psychosocial Well-Being in Historic Urban Landscapes

Field: Social Sciences (Social Sciences)

Although grounded theory (GT) has emerged as a popular research approach across multiple areas of social science, it has been less widely taken up by researchers working in the fields of urban planning and design. The application of GT enables uniquely innovative insights to be gained from qualitative data, but it has attracted criticism and brings its own challenges. This paper proposes a methodology that could be applied by other researchers in the field of urban research. Utilising constructivist GT as a qualitative approach, this research investigates how cultural memory impacts the psychosocial well-being and quality of life (QoL) of users of, and visitors to, historic urban landscapes (HULs). Based on the findings, it can be posited that the application of GT yields a rich and nuanced understanding of how users of HULs experience the settings in which they live, and the impact and significance on human psychosocial well-being of the cultural memories incarnated within such settings. The current paper also contends that GT enables researchers studying the built environment to construct inductively based theories. Lastly, the practical implications of developing GT for application to HUL management are discussed, both in regard to how users experience the contexts in which they live and the impact of such contexts on well-being and quality of life.
Arctic cyclones and their representation in climate models

Field: Earth and Planetary Sciences (Physical Sciences)

Synoptic-scale Arctic cyclones are atmospheric perturbations of thousands of kilometers size associated with a low pressure that form in the Arctic or move towards this region. They live between a few days and more than a month and are characterized by strong surface winds and precipitation. The specificity of Arctic cyclones, in comparison with mid-latitude ones, is that some of them, long-lived ones, have a cold-core vertical structure. Others have a warm-core mid-latitude-like structure. Arctic cyclones form a major hazard if human activities are to be continued, even intensified, in the Arctic region. As they transport heat and humidity, they also represent a key feature to understand Arctic climate, especially in a context of global warming. In order to simulate Arctic faster warming &#8211; i.e. polar amplification &#8211; in a realistic way, it is crucial to better understand Arctic cyclones life cycles and to improve their representation in the models. The aim of our study is to evaluate this representation in the IPSL climate model by analysing HighResMIP simulations run at four different spatial resolutions (Low (LR), Middle (MR), High (HR) and Very High (VHR)) and comparing with ECMWF-ERA5 reanalysis. To do so, Arctic cyclones are detected and tracked by applying the algorithm TempestExtremes to the mean sea level pressure (MSLP) field. Different cyclones&#8217; characteristics are analysed: their frequency, their lifetime and their intensity. Maps of genesis, lysis and track densities are also analysed. Preliminary results show that the higher the resolution, the higher the number of tracks. The model represents Arctic cyclones quite well in summer but is less skillful in winter with an overrepresentation of the most intense ones, especially above the continents and sea ice. This bias increases with the resolution. The ability of the model to represent interactions of Arctic cyclones with tropopause polar vortices and the transitions from baroclinic structure to axisymmetric cold-core structure is also investigated.