jimnoneill/paper-to-field-training huggingface dataset:
Phase 1 study of NB003, a broad-spectrum KIT/PDGFRα inhibitor, in patients with advanced gastrointestinal stromal tumors (GIST).

Field: Medicine (Health Sciences)

11518 Background: NB003 is a potent and selective small-molecule tyrosine kinase inhibitor of KIT/PDGFRα. It was designed to inhibit a broad spectrum of primary and acquired imatinib-resistant mutations in KIT/PDGFRα. Methods: This is a first-in-human phase 1 study in patients (pts) with advanced GIST who progressed on or intolerant to imatinib and other SoCs. Pts received oral NB003 twice daily (BID). An accelerated titration followed by a Bayesian optimal interval (BOIN) design was used. After the MTD or MAD was determined, putative RP2D(s) were explored to establish the RP2D. The primary endpoint was safety and tolerability. Other endpoints included PK, efficacy and mutational status by ctDNA. Results: As of Jan 10, 2024, 42 pts (median age 55 y [range 33–81]; 69% male; 71.4% ECOG PS 1; 69% primary mutation in KIT exon 11; median 4 prior TKI therapies [range 2–7]) were treated in dose escalation phase. Seven dose levels (DL) were tested, including 3mg (1 pt), 6mg (1 pt), 12mg (3 pts), 20mg (15 pts), 30mg (15 pts), 35mg (4 pts), 40mg (3 pts). The most frequent treatment-related adverse events (TRAEs) were asymptomatic CPK increased (92.9%), anaemia (78.6%), AST increased, face oedema, WBC decreased (76.2% each), periorbital oedema (66.7%), neutrophil count decreased (64.3%), amylase increased (57.1%), lipase increased (52.4%), platelet count decreased (45.2%), oedema peripheral (38.1%). The most frequent Grade ≥3 TRAEs were anaemia (61.9%), asymptomatic CPK increased (59.5%), neutrophil count decreased (23.8%), WBC decreased (21.4%). TRAEs leading to treatment discontinuation were reported in 2 pts (fatigue, tumor haemorrhage) at 20mg DL, 2 pts (AST increased, WBC decreased) at 30mg DL and 1 pt (face oedema) at 40mg DL, respectively. DLTs occurred in 2 pts at 40mg DL (fatigue, face oedema) and 2 pts at 30mg DL (febrile neutropenia, rash maculo-papular, AST increased). In 42 treated pts, the confirmed ORR was 26.2% (11/42, 95% CI:13.9, 42.0) per mRECISTv1.1 by investigator assessment, DCR was 73.8% (31/42, 95% CI:58.0, 86.1). Most of the responses (7/11) are still ongoing. Tumor responses were observed in pts with a broad spectrum of acquired resistance mutations in both ATP-binding site and activation loop of the kinase domain of KIT based on predose ctDNA (including 3 pts with exon11/13, 3 pts with exon11/17, 2 pts with exon17, 1 pt with exon16, 1 pt with exon 9/17, 1 pt not detected). A correlation is observed between changes in the KIT mutation allele fraction (MAF) in ctDNA and changes in tumor size from baseline. Conclusions: In heavily pretreated pts with advanced GIST, NB003 demonstrated a manageable safety profile with encouraging antitumor activity across a broad spectrum of secondary resistance mutations in KIT. The RP2D was defined as 20mg BID based on overall safety and efficacy. Expansion cohorts in different lines of GIST are currently under enrollment. Clinical trial information: NCT04936178 .
Comparison among U-17, U-20, and Professional Female Soccer in the GPS Profiles during Brazilian Championships

Field: Medicine (Health Sciences)

The purpose of this study was to compare and characterize the physical demand of official matches among under-17 (U-17), under-20 (U-20), and professional (Pro) female soccer players. All matches were from the U-17, U-20, and Pro National Brazilian Championships. Fourteen Pro matches, nine U-20 matches, and four U-17 matches were analyzed. The external load was measured by the global positioning system (GPS) and the internal workload was assessed by the ratings of perceived exertion (RPE) multiplied by the duration of the match. The activity profiles measured were total distance covered (km), total sprint distance (m) (speed > 18 km·h−1), number of accelerations and decelerations (between 1 and 2 m·s−2 and >3 m·s−2), and top speed (km·h−1). For the analysis, we standardized all the metrics (except the top speed) by the time (in minutes) played. The Pro group presented higher sprint distances, number of accelerations and decelerations, and top speeds, compared to U-20 and U-17. There was no difference in the total distance among groups, and there was no difference in any GPS metrics between U-20 and U-17. The RPE was higher in Pro and U-17, compared to U-20; however, the workload-RPE was higher in Pro, compared to both U-17 and U-20 groups. These findings provide important information for the evolution of physical performance according to age categories in elite female soccer players.
Air guitar using MyDAQ

Field: Engineering (Physical Sciences)

In the past, many ideas are birth forth through innovation, designs and significant budget poured in to develop new and cool products to improve life and change the way people live. In the rapid development of technology in the world today, processors and computers are getting faster and cheaper. Thus it is now easier for any one to develop new product with limited budget. In this project we will be using MyDAQ, a type of embedded system, which basically operate as computer system used for a particular purpose. The objective of this project is to use a type of embedded system call myDAQ to create something cool and fun. It will be a platform for a person who wants to do something that he can only visualize but not put into place due to the complexity and limitation of their knowledge and skill set In this project, I will be using myDAQ to create an air guitar that enable to user to create music without a real guitar. I will be using theory of circuit to link the control to the software as well as an accelerometer that detects movement, and transmit information to the computer. The success of it could give a rise to the start of virtual musical instrument.
Aneurysm of the cardiac ventricle. Its management by medical and surgical intervention.

Field: Medicine (Health Sciences)

Ventricular aneurysm is usually a complication of acute transmural myocardial infarction. The development of cardiac aneurysm represents a process of continued thinning and fibrosis of the necrotic tissue of the ventricular wall. Survival allows the development of a solid fibrous scar which of itself does not affect global ventricular function substantially. Hence, ventricular aneurysms can be present for up to 18 years without production of serious symptoms. The cases were reviewed of 45 patients in whom aneurysmectomy and myocardial revascularization were carried out. Surgical mortality was low (6.6 percent, 30 days); survival one year after operation was 76 percent, but at three years had fallen to 47 percent. Cause of late death was dominantly cardiac. In 19 patients post-operative study was done; although graft patency was observed in 98 percent, substantive improvement in ventricular performance was seen in a minority of patients. The outcome in patients with ventricular aneurysm is primarily related to the status of the residual myocardium and to the status of the vessels which supply it. The mechanism of clinical improvement after aneurysmectomy has not been clarified. However, the long-term results appear to be similar to those in patients with extensive myocardial infarction.
Effect of particle size and modulation frequency on the photoacoustic spectra of silica powders

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of particle size and modulation frequency on the photoacoustic spectra of silica powdersRaghoottama S. Pandurangi and Mohindar S. SeehraCite this: Anal. Chem. 1990, 62, 18, 1943–1947Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://pubs.acs.org/doi/10.1021/ac00217a009https://doi.org/10.1021/ac00217a009research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Particle filtering for on-line estimation of overflow losses in a hopper dredger

Field: Engineering (Physical Sciences)

A particle filter is applied to the estimation of overflow losses in a hopper dredger. The filter estimates online the overflow mixture density and flow-rate, based on the measurements of the total hopper volume, mass, incoming mixture density and flow-rate. These data are readily available on board of every modern hopper dredger. The main advantage of the proposed approach is that the particle filter uses straightforward nonlinear mass balance equations and does not rely on complex sedimentation models with uncertain parameters. The performance was evaluated in simulations as well as with real measurements and the results is encouraging. The filter can be used to improve parameter estimation in complex mechanistic models of the hopper sedimentation process and to facilitate decision making on board of the hopper dredger.
MPTH-40. COPY NUMBER ALTERATIONS IN PLEOMORPHIC XANTHOASTROCYTOMA AND ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA: CHARACTERIZATION OF 40 CASES BY SNP ARRAY

Field: Medicine (Health Sciences)

Pleomorphic xanthoastrocytoma (PXA), a rare localized brain tumor morphologically and genetically distinct from infiltrating astrocytoma, shows frequent BRAF V600E mutation, frequent loss of CDKN2A/B and lacks IDH1/2 mutation. To further characterize its underlying genetic alterations, we performed OncoScan SNP array in 40 PXAs: 26 PXA (WHO grade II) and 14 anaplastic (A-PXA) (WHO grade III). BRAF V600E mutation was present in 24 (60%) cases: 17 PXA (65%) and 7 A-PXA (50%). Homozygous CDKN2A/B deletion, the most frequent alteration (n=34,85%) together with other chromosome 9 alterations [including copy neutral loss of heterozygosity (cnLOH), loss, and gain], was present in an equal proportion of PXA (81%) and A-PXA (92%) and of BRAF V600E mutant (83%) and wildtype (88%) tumors. In 5 PXAs, chromosome 9 alterations were present in isolation. Whole chromosome gains/losses were frequent, including gains +7 (n=13), +5 (9), +20 (8), +21 (8), +2 (8), +12 (7), +15 (6) and losses -22 (14), -14 (8), -13 (6). Losses were significantly more common in A-PXA, including -22 (p=0.001), -14 (p=0.015), and -13 (p<0.001). Whole chromosome/whole arm cnLOH was identified in 14 cases, most commonly involving chromosome 9 (n=8). High level 8p and 12q amplification was identified in a single tumor. Five matched PXA and recurrent A-PXA were compared. Upon anaplastic transformation, two tumors demonstrated nearly identical copy number alterations (CNAs), two cases showed additional complex CNAs, and one case showed additional loss of -18q and partial -11q. Distinct areas of low- and high-grade morphology were analyzed in two tumors; one showed identical CNAs and one numerous additional complex CNAs. Overall, CDKN2A/B homozygous deletion is identified in the vast majority of PXA regardless of grade and BRAF mutation status and persists on recurrence/anaplastic transformation. The presence of BRAF mutation and CDKN2A/B loss may help to differentiate A-PXA from glioblastoma in morphologically challenging cases.
Optimal treatment with boceprevir for chronic HCV infection

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract There are 160–170 million people with chronic hepatitis C virus ( HCV ) infection worldwide. The marketing of protease inhibitors ( PI s) has been a milestone in the history of HCV therapy. In phase III studies, up to 75% of the patients achieved a sustained virological response ( SVR ) after triple therapy with pegylated‐interferon ( PEG ‐ IFN )‐α, ribavirin ( RBV ) and boceprevir ( BOC ). However, triple regimens are more expensive and associated with drug–drug interactions ( DDI s) and more adverse events ( AE s). According to results in ‘real‐world’ settings, safety seems to be limited, in particular in patients with advanced liver disease. To optimize efficacy while minimizing AE s as well as costs, the optimal treatment strategy must be determined for BOC . Optimizing treatment is based on patient selection, the most efficient treatment design, management of side effects and the challenge of DDI s. Therapy‐associated risks, treatment urgency and chances of SVR must all be considered for patient selection. In addition, certain differences between the two approved PI s may help identify the ideal candidates for each HCV PI . Optimal treatment design is based on the results of phase II and III studies, in which different approaches have been tested including ‘lead‐in’ and response‐guided strategies. Treatment regimens and stopping rules recommended by the FDA and EMA should normally be followed. Still, there are some cases in which more personalized strategies may be more promising. Management of side effects is a major challenge and plays a crucial role in ensuring safety and adherence.
A WORK ON THE ROOT CAUSES OF RURAL MIGRATION: THE CASE OF TURKEY

Field: Social Sciences (Social Sciences)

Abstract Rural migration is a common phenomenon observed in the population all across the world and especially the developing countries. Rural migration has historically been an important part of the urbanization process and continues to be significant in scale, even though migration rates appear to have slowed down in some countries. Agriculture and rural development are key to addressing the root causes of migration. By 2050, over half of the population in the least developed countries wills still live-in rural areas. Turkey is also a developing country, a result of industrialization and urbanization after 1950, has become a country where rural migration. To conduct scientific studies concerning rural migration in developing countries as Turkey is quite important. Because, this kind of studies, to a certain extent, put forward a country’s socio-economic development and change. The lack of data and its acquisition is one of the major problems in rural migration studies. Based on this point, the data of rural migration in Turkey were associated with the populations of towns and villages, which have negative net migration velocities (NMV), that is which are migration-sending, according to Turkish Statistical Institution (TSI) data, and accordingly, new and tangible data acquirement method was used in this study. In this study, it was concluded that there is an inverse correlation between the number of cattle (head), that of small cattle (head) and cultivated agricultural land (ha), moreover, there is a correlation in the shape of inverse N, between agricultural production value per capita (TL) and rural migration.
An Autoethnographic Examination of 1990s Film as a Site of Critical Public Pedagogy

Field: Arts and Humanities (Social Sciences)

This research is an exploration of my evolving relationship with popular culture: as an activist, an educator, and a self-described pop-culture geek. Combining aspects of critical analytic autoethnography (Taber, 2012) with feminist discourse analysis (Lazar, 2007), I examine three key films: Scream (Craven, 1996), Practical Magic(Dunne, 1998), and Disturbing Behavior (Nutter, 1998), as well as three characters in these films whom I identify as having had a large influence on me as a teenager, particularly in fostering my ongoing (un)learning surrounding the willful subject (Ahmed, 2014). These three characters are Sidney Prescott from Scream, Sally Owens from Practical Magic, and Rachel Wagner from Disturbing Behavior.
What are the clinical and research lessons learned from immunomodulators and other therapies during the COVID-19 pandemic?

Field: Medicine (Health Sciences)

Purpose of review The development and use of immunomodulators and other therapies during the coronavirus disease 2019 (COVID-19) pandemic provided several lessons with respect to these therapies, and to how medical researchers and clinicians should approach the next pandemic. Recent findings New or repurposed therapies, particularly immunomodulator treatments, for the treatment of an infectious disease will always be associated with inherent patient risk and this was the case during the COVID-19 pandemic. The concomitant development and use of effective antimicrobial therapies along with close monitoring for secondary infections is paramount for patient safety and treatment success. The development of immunomodulators and other therapies during the COVID-19 pandemic further highlighted the importance of maintaining high standards for medical research for all potential treatment with large double-blind placebo-controlled trials and peer review being the best mode of disseminating medical results rather than social media outlets. Summary The next new and emerging pandemic will undoubtedly share many of the same challenges posed by COVID-19. It is important that researchers and clinicians learn from this experience, adhere to tried and true clinical care, all the while conducting high quality research aimed at developing definitive treatments.
Research on the Fertility of the Hybrid between Wild Mulberry with Long Fruit Size and Cultivar

Field: Agricultural and Biological Sciences (Life Sciences)

[Objective] The property of the distant hybridization between wild mulberry species and its cultivar was explored.[Method] Two hybridization models:wild mulberry(maternal)with long fruit size × cultivars(paternal)and mulberry cultivars(maternal)× wild species(maternal)with long fruit size(paternal),were established for the research on the fertility of their offspring.[Results] There was a great difference in the pregnancy rate,seed-setting rate and fertility of the different types of distant hybridizations and the different combinations from same type of distance hybridization.The pregnancy rate,the seed-setting rate and the fertility of wild mulberry(maternal)with long fruit size × cultivars(paternal)was 45.35%-71.36%(average value:56.64%),41.11%-60.36%(average value:50.45%)and 12.85%-33.75%(average value:22.31%),respectively;and the pregnancy rate,the seed-setting rate and the fertility of mulberry cultivars(maternal)× wild species(maternal)with long fruit size(paternal)was 57.03%-23.06%(average value:39.39%),26.48%-50.89%(average value:34.04%)and 4.26%-18.33%(average value:9.40%).The pregnancy rate,the seed-setting rate and the fertility of wild mulberry(maternal)with long fruit size × cultivars(paternal)was 17.25%,16.41% and 12.91% higher than these of mulberry cultivars(maternal)× wild species(maternal)with long fruit size(paternal).[Conclusion] Many more abundant materials for the innovation of mulberry genetic material and the breeding for new variety were provided.
Wilhelm Loehe's 1866 Sermons on the Lord's Supper

Field: Arts and Humanities (Social Sciences)

This article examines a sermon series on the Lord's Supper preached by Wilhelm Loehe in 1866. He suggests several outward disciplines that can improve the subjective experience of receiving the Lord's Supper, but he distinguishes this aspect from the divine gift of Christ's body and blood and the faith that receives him unto salvation. Loehe identified Christians primarily as disciples in need of both intellectual education and spiritual training. At other points Loehe describes the ideal Christian. This leads to his discussion of actual Christians in need of repentance and faith.
Additional file 2 of Yellow loosestrife (Lysimachia vulgaris var. davurica) ameliorates liver fibrosis in db/db mice with methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Additional file 2. The uncropped membrane images of western blotting analysis.
High-Risk Conversations: A Response to Reamer

Field: Health Professions (Health Sciences)

Journal Article High-Risk Conversations: A Response to Reamer Get access Carole Bahou, Carole Bahou Carole Bahou, MSW, is Social Worker, AIDS Center Program, St. Luke's-Roosevelt Hospital Center, 428 West 59th Street, New York, NY 10019. Marlene Gralnick, MSW, MA in Community Health Education, is Social Worker, AIDS Center Program, St. Luke's-Roosevelt Hospital Center. Search for other works by this author on: Oxford Academic PubMed Google Scholar Marlene Gralnick Marlene Gralnick Carole Bahou, MSW, is Social Worker, AIDS Center Program, St. Luke's-Roosevelt Hospital Center, 428 West 59th Street, New York, NY 10019. Marlene Gralnick, MSW, MA in Community Health Education, is Social Worker, AIDS Center Program, St. Luke's-Roosevelt Hospital Center. Search for other works by this author on: Oxford Academic PubMed Google Scholar Social Work, Volume 34, Issue 3, May 1989, Pages 262–264, https://doi.org/10.1093/sw/34.3.262 Published: 01 May 1989 Article history Accepted: 10 March 1989 Published: 01 May 1989
Differential presentations of arterial thromboembolic events between venous thromboembolism and atrial fibrillation patients

Field: Medicine (Health Sciences)

Background: Atrial fibrillation (AF) and venous thromboembolism (VTE) share several risk factors related to arterial thromboembolism. No study has reported the differential contribution to arterial thromboembolic events and mortality between these two conditions in the same population. Methods: We included AF and VTE national cohorts derived from Taiwan National Health Insurance Research Database between 2001 and 2013. The eligible population was 314,861 patients in the AF cohort and 41,102 patients in the VTE cohort. The primary outcome was arterial thromboembolic events, including ischemic stroke, extracranial arterial thromboembolism (ECATE) and myocardial infarction (MI). Secondary outcomes were all-cause mortality and cardiovascular death. Results: After a 1:1 propensity matching, 32,688 patients in either group were analyzed. The risk of arterial thromboembolic events was lower in the VTE cohort than that in the AF cohort (subdistribution hazard ratio [SHR], 0.60; 95% confidence interval [CI], 0.57–0.62)). The risk of ischemic stroke (SHR, 0.44; 95% CI, 0.42–0.46) and MI (SHR, 0.80; 95% CI, 0.72–0.89) were lower in the VTE cohort, while the risk of ECATE (SHR, 1.23; 95% CI, 1.14–1.33; particularly lower extremities) was higher in the VTE cohort. All-cause mortality rate was higher in the VTE cohort (HR, 1.18; 95% CI, 1.15–1.21) while the risk of cardiovascular death was lower in the VTE cohort (HR, 0.96; 95% CI, 0.93–0.995). Conclusions: Patients with AF had higher risks of arterial thromboembolic events compared to patients with VTE, despite having risk factors in common. The VTE cohort had higher risks of all-cause mortality and ECATE, particularly lower extremity events, compared to AF patients. These differential manifestations of thromboembolism sequelae in AF and VTE merit further investigation.
Clouddrift: a Python package to accelerate the use ofLagrangian data for atmospheric, oceanic, and climate sciences

Field: Computer Science (Physical Sciences)

Elipot et al., (2024). Clouddrift: a Python package to accelerate the use of Lagrangian data for atmospheric, oceanic, and climate sciences. Journal of Open Source Software, 9(99), 6742, https://doi.org/10.21105/joss.06742