jimnoneill/paper-to-field-training huggingface dataset:
Study on the Knowledge of Human Papilloma Virus in Female University Students

Field: Health Professions (Health Sciences)

Purpose: This study was performed to examine the knowledge of HPV in female university students. Methods: Participants consisted of 285 female university students(nursing major;153, others;132). A dichotomy with 20 items of HPV knowledge was developed by a researcher. Results: Reliability of the HPV knowledge tool was Cronbach' alpha .87, and Split-half Guttman coefficient .85. Correction rates of HPV knowledge by item ranged from 19.6 to 76.8%. There were no significant differences in HPV knowledge scores by major group or sex related characteristics. Conclusions: Accurate, university wide education regarding HPV knowledge for female university students should be done regardless of the major; nursing or not. Replication studies with different ages or sex groups and application of HPV education in relation to STI prevention and cervical cancer prevention are recommended.
MiR-34a regulates Schwann cell proliferation and migration by targeting CNTN2

Field: Neuroscience (Life Sciences)

The proliferation and migration of Schwann cells contribute to axonal outgrowth and functional recovery after peripheral nerve injury. Previously, several microRNAs were abnormally expressed after peripheral nerve injury and they played important roles in peripheral nerve regeneration. However, the role and underlying mechanism of miR-34a in peripheral nerve injury remain largely unknown. The levels of miR-34a and contactin-2 (CNTN2) were detected by quantitative real-time PCR. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide and transwell assays were used to examine cell proliferation and migration, respectively. The protein level of CNTN2 was measured by western blot. The binding sites of miR-34a and CNTN2 were predicted by the online software and confirmed by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. Following sciatic nerve injury, the expression of miR-34a was downregulated in the crushed nerve segment, reaching a minimum at the seventh day. Knockdown of miR-34a enhanced the axon outgrowth of dorsal root ganglion neurons. Moreover, miR-34a overexpression evidently inhibited the proliferation of Schwann cells, whereas its knockdown showed the opposite effects. In addition, CNTN2 was a direct target of miR-34a and its expression was negatively regulated by miR-34a in the crushed nerve segment. Besides, CNTN2 overexpression or knockdown could reverse the effects of miR-34a upregulation or downregulation on proliferation and migration of Schwann cells, respectively. Collectively, miR-34a inhibited the proliferation and migration of Schwann cells via targeting CNTN2, which might provide a new approach to peripheral nerve regeneration.
Get C_TS452_2020 Exam Dumps 2022 And Succeed Inside your Career

Field: Business, Management and Accounting (Social Sciences)

Seeking For Updated SAP C_TS452_2020 PDF Exam Dumps 2022?\n\nThe one particular point which every single C TS452 2020 exam questions aspirant desperately looks for will be the likelihood of obtaining the valid C_TS452_2020 pdf dumps 2022. If you are also among these SAP Certified Application Associate experts then we advocate you to go for the valid C_TS452_2020 pdf dumps 2022 of DumpsCloud for the preparation of SAP Certified Application Associate - SAP S/4HANA Sourcing and Procurement exam. The SAP C TS452 2020 pdf exam dumps are one of its personal type.\n\n100% Genuine C_TS452_2020 PDF Dumps Of DumpsCloud\n\nThe C_TS452_2020 braindumps questions of DumpsCloud are one of many top rated rated and most recent C_TS452_2020 pdf questions that had been verified by the SAP specialists and these SAP professionals made this positive that you is going to be capable to ace the C TS452 2020 test questions in first attempt. Also the C_TS452_2020 dumps pdf of DumpsCloud includes the 100% genuine C_TS452_2020 exam questions and answers that will make it easier to in acquiring to know the real topics of SAP Certified Application Associate exam.\n\nUndergo Testimonials of SAP C_TS452_2020 Dumps PDF\n\nBut that is not it, the C_TS452_2020 pdf dumps of DumpsCloud offers you the ideal likelihood to prosper in your C TS452 2020 exam questions preparation because the C_TS452_2020 dumps pdf 2022 of DumpsCloud are being curated by the SAP specialists. These business professionals have put their knowledge and all information in these C_TS452_2020 pdf exam dumps. Therefore we are able to certainly say that C_TS452_2020 pdf questions 2022 are among the leading rated and top sources for the preparation from the SAP Certified Application Associate - SAP S/4HANA Sourcing and Procurement exam and that's no joke. The C_TS452_2020 braindumps have a highest passing price among all the SAP Certified Application Associate - SAP S/4HANA Sourcing and Procurement exam preparation material and you can get that reality by going by means of the testimonials of C_TS452_2020 exam dumps 2022 exactly where it is possible to come across the a lot of constructive evaluations concerning the SAP C_TS452_2020 questions pdf 2022.\n\nGet Now: https://www.dumpscloud.com/exam/C_TS452_2020\n\n24/7 Client Assistance More than C_TS452_2020 Braindumps questions\n\nNot just this, the C_TS452_2020 dumps pdf 2022 of DumpsCloud also can be obtained together with the 100% money back guarantee, producing your investment top safe on C TS452 2020 pdf exam dumps. But that is not all, the SAP C_TS452_2020 pdf dumps of DumpsCloud also includes the 24/7 customer assistance more than the C_TS452_2020 pdf questions, this makes the C_TS452_2020 pdf dumps 2022 a well-known source for the preparation of SAP Certified Application Associate - SAP S/4HANA Sourcing and Procurement exam. In short the C TS452 2020 braindumps pdf of DumpsCloud should be your go through gate for the preparation of C TS452 2020 exam questions.
Data from Zoledronic Acid Reverses the Epithelial–Mesenchymal Transition and Inhibits Self-Renewal of Breast Cancer Cells through Inactivation of NF-κB

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

<div>Abstract<p>Zoledronic acid, a third-generation bisphosphonate, has been shown to reduce cell migration, invasion, and metastasis. However, the effects of zoledronic acid on the epithelial–mesenchymal transition (EMT), a cellular process essential to the metastatic cascade, remain unclear. Therefore, the effects of zoledronic acid on EMT, using triple-negative breast cancer (TNBC) cells as a model system, were examined in more detail. Zoledronic acid treatment decreased the expression of mesenchymal markers, N-cadherin, Twist, and Snail, and subsequently upregulated expression of E-cadherin. Zoledronic acid also inhibited cell viability, induced cell-cycle arrest, and decreased the proliferative capacity of TNBC, suggesting that zoledronic acid inhibits viability through reduction of cell proliferation. As EMT has been linked to acquisition of a self-renewal phenotype, the effects of zoledronic acid on self-renewal in TNBC were also studied. Treatment with zoledronic acid decreased expression of self-renewal proteins, BMI-1 and Oct-4, and both prevented and eliminated mammosphere formation. To understand the mechanism of these results, the effect of zoledronic acid on established EMT regulator NF-κB was investigated. Zoledronic acid inhibited phosphorylation of RelA, the active subunit of NF-κB, at serine 536 and modulated RelA subcellular localization. Treatment with zoledronic acid reduced RelA binding to the Twist promoter, providing a direct link between inactivation of NF-κB signaling and loss of EMT transcription factor gene expression. Binding of Twist to the BMI-1 promoter was also decreased, correlating modulation of EMT to decreased self-renewal. On the basis of these results, it is proposed that through inactivation of NF-κB, zoledronic acid reverses EMT, which leads to a decrease in self-renewal. <i>Mol Cancer Ther; 12(7); 1356–66. ©2013 AACR</i>.</p></div>
Corrosion Behavior of Cobalt–Chromium‐Based Laser Claddings Reinforced with Boron Nitride, Graphene Oxide, and Graphite.

Field: Materials Science (Physical Sciences)

In this article, the corrosion resistance of a cobalt–chromium‐based laser cladding reinforced with different microparticles: boron nitride, graphene oxide, and graphite, added for increased tribological performance, is explored. Samples are fabricated by premixing cobalt–chromium powder with microparticle additions and cladding onto 316L stainless steel base metal. The corrosion behavior is measured in industrially relevant applications: 1 m acetic acid and 3.5 wt% NaCl, using open‐circuit potential, electrochemical impedance spectroscopy, linear polarization resistance, and cyclic polarization. Laser ablation–inductively coupled plasma–mass spectrometry is used to analyze the distribution of the chemical elements throughout the coatings. The reference cladding's corrosion resistance is outstanding in both electrolytes, with a corrosion rate (CR) of ≤0.19 μm year −1 and no pitting tendencies. With the addition of microparticles, the claddings maintain their remarkable pitting resistance, but show an increase in CR up to 0.98 μm year −1 due to the nonuniform distribution of the microparticles into the matrix.
Demonstration of HPV 24 in long-standing Heck's disease with malignant transformation.

Field: Medicine (Health Sciences)

We report on the rare case of a 64-year-old European woman with a viral acanthoma of the oral mucosa of the clinical Heck type with unprecedented molecular-biological proof of HPV 24 DNA and so far undescribed malignant transformation with a long existence of the vegetation. After surgical therapy a circumscribed relapse of viral acanthoma developed, which responded favourably to a combined antiviral and antiproliferative therapy with acitretin perorally and interferon, first subcutaneously, later intralesionally for 3 months.
Erosion plume characteristics determination in ablation of metallic copper, niobium, and tantalum targets

Field: Physics and Astronomy (Physical Sciences)

On irradiation of metallic targets from niobium and tantalum with excimer XeCl laser (308 nm) in vacuum the UV and visible spectra of erosion plume were obtained. The erosion plume after ablation of copper, niobium and tantalum targets was studied using Langmuir probe. The ion and electron probe currents were obtained in the range from 0.2 to 2.2 J/cm-2 of energy densities at the target with probe-to-target separations from 10 to 133 mm. Multimodal distributions of ions by scatter velocities have been revealed. The spatial and temporal dependencies of electron probe currents were obtained in real time. The electron temperature of different plume regions was determined from a series of I-U characteristics taken at different distances between probe and copper or tantalum target. It was established that the plume electron temperature is non-uniform and has a maximum value in front of the plume. The acceleration of tantalum ions on plume irradiation with cw CO2 laser recorded. The increase in ions energy from 25 to 50 eV was observed. The emission optical spectra were used in studying the plume qualitative composition. The velocities of atom and ion scatter were measured by the time-of-flight method from the emission optical spectra.
Constraints of young prospective tourism entrepreneurs in the semi-rural areas in KwaZulu-Natal

Field: Social Sciences (Social Sciences)

Tourism is increasingly regarded as a potential catalyst for rural economic development. As it stands, the global economic situation and the progress of youth entrepreneurship in developing economies are leaving a lot to be desired. Cultural diversity, level of education, dire market standards, and grim sociopolitical environments are some of the factors that should be taken into consideration when aiming to create an enabling setting that will open tourism entrepreneurship opportunities for a developing country like South African. This study’s objectives are the investigation of the limitations that prevent young people from pursuing tourism entrepreneurial activities in a semi-rural area. This research was conducted in the Umdoni Local Municipal area, a semi-rural area in KwaZulu-Natal, South Africa. A sample size of 126 respondents from the selected semi-rural area was selected to participate in this study. This was achieved using a snowball sampling technique and the results were analysed using Statistical Package for Social Sciences. The study highlights that inability to secure financial support is one of the primary constraints for the setting-up of a new business. The study also found that youth support structures, such as National Youth Development Agency and the Department of Trade and Industry, that should stimulate and develop tourism entrepreneurship for the youth in the Umdoni Local Municipality area, are not accessible. This research recommends that finance for youth entrepreneurship initiatives in the tourism sector be introduced by financial institutions and access should not be tortuous. Government policies should be examined in terms of their effectiveness on entrepreneurship establishment, as well as their regulatory burden on new start-ups.
1 ON THE SPLITTING METHOD FOR SCHRODINGER-LIKE EVOLUTION EQUATIONS

Field: Mathematics (Physical Sciences)

Using the approach of the splitting method developed by I. Gyongy and N. Krylov for parabolic quasi linear equations, we study the speed of conver- gence for general complex-valued stochastic evolution equations. The approxima- tion is given in general Sobolev spaces and the model considered here contains both the parabolic quasi-linear equations under some (non strict) stochastic parabolic- ity condition as well as linear Schrodinger equations Once the well-posedeness of a stochastic differential equation is proved, an im- portant issue is to provide an efficient way to approximate the uniquesolution. The aim of this paper is to propose a fast converging scheme which gives a simulation of the trajectories of the solution on a discrete time grid, and in terms of some spa- tial approximation. The first results in this direction were obtained for Stochastic Differential Equations and it is well-known that the limit is sensitive to the ap- proximation. For example, the Stratonovich integral is the limit of Riemann sums with the mid-pint approximation and the Wong Zakai approximation also leads to Stratonovich stochastic integrals, and not to the Ito ones in this finite dimensional framework. There is a huge literature on this topic for stochastic PDEs, mainly extending classical deterministic PDE methods to the stochastic framework. Most of the papers deal with parabolic PDEs and take advantage of the smoothing ef- fect of the second order operator; see e.g. (9), (21), (14), (12), (13), (13), (18) and the references therein. The methods used in these papers are explicit, implicit or Crank- Nicholson time approximations and the space discretization is made in terms of finite differences, finite elements or wavelets. The corresponding speeds of convergence are the strong ones, that is uniform in time on some bounded interval (0,T) and with various functional norms for the space variable. Some papers also study numerical schemes in other hyperbolic situations, such as the KDV or Schrodinger equations as in (5), (3) and (4). Let us also mention the weak speed of convergence, that is of an approximation of the expected value of a functional of the solution by the similar one for the scheme obtained by (4) and (6). These references extend to the
Monomer dynamics of a wormlike chain

Field: Physics and Astronomy (Physical Sciences)

We derive the stochastic equations of motion for a tracer that is tightly attached to a semiflexible polymer and confined or agitated by an externally controlled potential. The generalised Langevin equation, the power spectrum, and the mean-square displacement for the tracer dynamics are explicitly constructed from the microscopic equations of motion for a weakly bending wormlike chain by a systematic coarse-graining procedure. Our accurate analytical expressions should provide a convenient starting point for further theoretical developments and for the analysis of various single-molecule experiments and of protein shape fluctuations.
Targeted therapy using phage technology: a computational and experimental breast cancer study

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

During the past two decades cancer biology knowledge has widely increased and shifted the paradigm of cancer treatment from nonspecific cytotoxic agents to selective, mechanism-based therapeutics. Initially, cancer drug design was focused on compounds that rapidly killed dividing cells. Though still used as the backbone of current treatments, these highly unspecific targeting drugs lead to significant toxicity for patients, narrowing the therapeutic index, and frequently lead to drug resistance. Therefore, cancer therapies are now based on cancer immunotherapy and targeted agents, whereas novel treatments are strategically combining both to improve clinical outcomes. Despite the nanotechnology advances dictating the development of targeted therapies in diverse classes of nano-based carriers, virus-based vectors still remain highly used due to its biocompatibility and specificity for the target. Particularly, bacteriophages are an interesting alternative ‘nanomedicine’ that can combine biological and chemical components into the same drug delivery system. The great potential of this novel platform for cancer therapy is the ability to genetically manipulate the virus-vector to display specific targeting moieties. Phage display technology, a general technique used for detecting interfaces of various types of interacting proteins outside of the immunological context, allows the target agents to locate the target (with an increased selection process for the specific binding – termed biopanning) and play their essential role inhibiting molecular pathways crucial for tumour growth and maintenance. Phage display specificity core is related with the binding of small peptides displayed at their coat or capsid proteins, enriched during biopanning. Bioinformatics plays an important role in testing and improving phage display libraries by effective epitope mapping, selecting from a large set of random peptides those with a high binding affinity to a target of interest. In this work we demonstrate the screening of a manually constructed 7-mer peptide library of M13KE phage particles against MDA-MB-231 and -435 cancer cell lines. Two peptides – TLATVEV and PRLNVSP – with high affinity for the referred cells were identified, respectively. Based on computationally predicted epitopes based on the peptides extracted from this library the linear peptide sequence was docked onto known membrane proteins from the used cell lines and peptides-proteins interactions were mapped. Umbrella sampling studies were performed to predict the binding affinity and to improve future rational design of binding peptides to these cancer cells.
Plato, Xenophon, and the Laws of Lycurgus

Field: Arts and Humanities (Social Sciences)

The relation between the opening section of Plato’s Laws and Xenophon’s Constitution of the Lacedaemonians usually goes unnoticed. I draw attention to its importance for understanding Plato’s project in the dialogue. Section 1 shows that the view proposed by Plato’s Athenian Visitor that Lycurgus made virtue in its entirety the goal of his statecraft was anticipated in Xenophon’s treatise. It has to be treated as an interpretation of the Spartan politeia alternative to that advanced by the Athenian’s interlocutors, which Plato could hope to be taken seriously as such. The second section focuses on the legislative programme the Athenian says he had hoped to hear ascribed to the Cretan and Spartan lawgivers. Plato can expect recognition by the reader that the programme is properly Spartan and Cretan by virtue of its echoes of the programme attributed to Lycurgus by Xenophon. The third section argues that in making law primarily concerned with fostering the proper development, conduct, and treatment of human beings at every stage of the life cycle, above all by provision for sound customary practices and the like, Plato adopts the approach to law making taken by Xenophon’s Lycurgus.
What Do Halo CMEs Tell Us about Solar Cycle 25?

Field: Physics and Astronomy (Physical Sciences)

Abstract It is known that the weak state of the heliosphere due to diminished solar activity in cycle 24 backreacted on coronal mass ejections (CMEs) to make them appear wider for a given speed. One of the consequences of the weak state of the heliosphere is that more CMEs appear as halo CMEs (HCMEs), and halos are formed at shorter heliocentric distances. Current predictions for the strength of solar cycle (SC) 25 range from half to twice the strength of SC 24. We compare the HCME occurrence rate and other properties during the rise phase of cycles 23, 24, and 25 to weigh in on the strength of SC 25. We find that HCME and solar wind properties in SC 25 are intermediate between SCs 23 and 24, but closer to SC 24. The HCME occurrence rate, normalized to the sunspot number, is higher in SCs 24 and 25 than in SC 23. The solar wind total pressure in SC 25 is ∼35% smaller than that in SC 23. Furthermore, the occurrence rates of high-energy solar energetic particle events and intense geomagnetic storms are well below the corresponding values in SC 23, but similar to those in SC 24. We conclude that cycle 25 is likely to be similar to or slightly stronger than cycle 24, in agreement with polar-field precursor methods for cycle 25 prediction.
Proximal tibial strains following unicompartmental knee arthroplasty (UKA) : a finite element study

Field: Engineering (Physical Sciences)

Unicompartmental knee arthroplasty (UKA) is well known as an effective treatment for osteoarthritis in recent years. Many studies have proven that UKA is efficient and reliable. However, complications after UKA cannot be eliminated. Fracture of proximal tibial is one of the critical failures studied for many years without a proper solution. Such failure may be attributed by erroneous surgical techniques or improper patient selection. Understanding the cause of fracture may help the surgeon avoid mistakes during surgery as well as preselection of appropriate patient for this treatment. This project used finite element analysis to evaluate the stress distribution on the proximal tibial following UKA. A three-dimensional (3D) tibia bone model was created with computed tomography (CT) scan data obtained from a human knee. The 3D model was used to investigate the effect of resection angle and extended saw-cut at the L-cut region on the stress distribution of the proximal tibial. This study found that smaller angle of resection slope lowers the stresses on the proximal tibial and extended saw-cut dramatically increases the stress concentration at the web cut region. Further work may include validation of the finite element model using the same cadaveric bone as the experiment and the stress distribution during a gait cycle after UKA.