jimnoneill/paper-to-field-training huggingface dataset:
Dioscin induces ferroptosis to suppress the metastasis of gastric cancer through the SLC7A11/GPX4 axis

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The prognosis of gastric cancer (GC) remains poor due to metastases and resistance to chemotherapy. Ferroptosis is a novel cell death regulation mode characterized by iron dependence and lipid peroxidation. Dioscin, a compound extracted from the Paris polyphylla rhizomes roots, has been shown to have an inhibitory effect on cancers. However, whether it induces ferroptosis to participate in anti-cancer metastasis remains unclear. The ability of gastric cancer cells to invade and migrate was evaluated by wound healing and transwell assays. Malondialdehyde (MDA), glutathione (GSH) assay kit, and dichlorofluorescin diacetate (DCFH-DA) fluorescent probes were used to detect ferroptosis in gastric cancer cells. The expression levels of glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11) were detected by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot methods. The rescue assay was performed by adding Ferrostatin-1 (Fer-1) co-treatment to verify that Dioscin inhibited gastric cancer metastasis by participating in ferroptosis. Dioscin inhibited gastric cancer cells’ wound healing, migration, and invasion process. In addition, Dioscin increased the level of reactive oxygen species (ROS) and MDA while decreasing GSH level, and induced ferroptosis of gastric cancer cells. Fer-1, an inhibitor of ferroptosis, could reverse the effect of Dioscin. In terms of mechanism, Dioscin induced ferroptosis through SLC7A11/GPX4 axis and was involved in the regulation of inhibiting metastasis of gastric cancer. These results suggested that Dioscin was involved in anti-cancer metastasis by inducing ferroptosis. The metastasis of gastric cancer cells is related to the regulation of ferroptosis;Dioscin induced ferroptosis in gastric cancer cells;Dioscin regulated the ferroptosis pathway to inhibit metastasis of gastric cancer cells. The metastasis of gastric cancer cells is related to the regulation of ferroptosis; Dioscin induced ferroptosis in gastric cancer cells; Dioscin regulated the ferroptosis pathway to inhibit metastasis of gastric cancer cells.
Palliation of tracheobronchial malignant obstruction with metal stents in emergency conditions.

Field: Medicine (Health Sciences)

Self-expanding metal stent placement is an easy and safe method, does not require general anaesthesia, is less traumatic and well tolerated, is quick to be performed and then can be used in emergencies. Nevertheless, it is impossible to remove the stent in case of malpositioning. Although this group is small, endobronchial stenting using metallic prostheses permits immediate ventilation and palliation of large airway obstruction.
The relational archive of the Khmer Republic (1970–1975): re-visiting the ‘coup’ and the ‘civil war’ in Cambodia through written sources

Field: Arts and Humanities (Social Sciences)

If there is a period in Cambodia’s history that has been overlooked and disparaged, it is certainly the republican one (1970–1975). The Khmer Republic is often viewed as a corrupt, incompetent regime–an interregnum doomed to failure. This article revisits this narrative through currently available written sources. It argues that a cultural approach to the existing records helps us understand how such a negative view, still prevailing today, was discursively constructed. The analysis of the interpretations of a range of protagonists, observers and academics contributes to a critical historiography that might challenge assumptions and clichés about the Republic. This implies a re-working of the ‘republican archive’, a multiform and scattered body that presents a structural imbalance due to the discrepancy between the limited sources coming from the Republic itself and the significant amount of US records. The article reassembles these archival materials. It proposes a different reading of these documents in terms of discipline. It suggests that this might be the first step towards reassessing the Republic and the two dominant themes of that period: the overthrow of head of state, Prince Norodom Sihanouk, in 1970 (which marked the end of the monarchy) and the civil war.
Anabolic Steroids: A Choice with Consequences

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Since anabolic steroids became available, athletes have used them for a competitive edge and amateur and profession body builders for the “perfect” toned body. Discussions on the consequences of taking anabolic steroids have been contentious, especially since there are no controlled studies to clarify the matter. The purpose of my research is to bring to light the observational evidence which is overwhelming and can’t be ignored especially when students in primary and secondary education are experimenting with these drugs. I will review the legitimate medical purpose of anabolic steroids. I will also review the physiologic reasons athletes and body builders use them. In addition, I will list all the possible side effects for males and females taking this drug. One example I will emphasize is the number of professional wrestlers who have died at a young age of heart attacks. I will delve into the factors that motivated people to use anabolic steroids including fame, achievement, money, power, and looks and list those factors that influence a school age student’s choice for using these drugs. It is my belief that continued legal enforcement, education and awareness are essential to stemming this problem.
Reconstruction of Fission Product Distribution from Tomographic Scans in TRISO Fuel Graphitic Matrix and Nuclear Grade Graphites

Field: Physics and Astronomy (Physical Sciences)

An image reconstruction method was developed to rectify shortcomings of earlier methods that became apparent as destructively sampled data became available. This reconstruction method was applied to the tomographic gamma scans of nuclear graphite and graphitic matrix samples from AGR-3/4. There is generally agreement between profiles measured via destructive sampling of these rings and profiles from tomographic reconstruction.
Manihot peruviana PER415-3B

Field: Agricultural and Biological Sciences (Life Sciences)

Plant Genetic Resource.
Taxonomy: Manihot peruviana
Common name(s): cassava
Conserved by: Centro Internacional de Agricultura Tropical (CIAT), Colombia
Local sample unique identifier: PER415-3B
Method of creation: Acquisition
Date: 1992-12-12
Historical: Yes
Biological status: Wild
MLS status: Included
Glucose Effects on Memory and Other Neuropsychological Tests in Elderly Humans

Field: Neuroscience (Life Sciences)

Recent experiments indicate that peripheral glucose administration enhances memory in rodents and humans. This study examined the effects of glucose on memory and nonmemory measures of neuropsychological functioning in elderly humans. Healthy older adults were given a series of neuropsychological tests after drinking glucose- or saccharin-flavored lemonade. A repeated measures design using counter-balanced beverages and tests was used. Glucose enhanced performance on declarative memory tests but not on short-term or nonmemory neuropsychological measures. Glucose tolerance predicted performance on declarative memory tasks but not on other measures.
Canines in Cervantes and Velázquez

Field: Arts and Humanities (Social Sciences)

The study of the creation of canine breeds in early modern Europe, especially Spain, illustrates the different constructs against which notions of human identity were forged. This book is the first comprehensive history of early modern Spanish dogs and it evaluates how two of Spain's most celebrated and canonical cultural figures of this period, the artist Diego Velázquez and the author Miguel de Cervantes, radically question humankind's sixteenth-century anthropocentric self-fashioning. In general, this study illuminates how Animal Studies can offer new perspectives to understanding Hispanism, giving readers a fresh approach to the historical, literary and artistic complexity of early modern Spain.
Adverse Childhood Events, Post-Traumatic Stress Disorder, Infectious Encephalopathies and Immune-Mediated Disease

Field: Medicine (Health Sciences)

Adverse Childhood Events (ACE), Post-Traumatic Stress Disorder (PTSD), and infectious encephalopathies are associated with immune-mediated diseases. Data supporting this are reviewed, and an integrated hypothesis is provided. All three can be associated with intrusive symptoms and temporal lobe pathology. ACE and PTSD are accompanied by an impaired mental capacity to differentiate external danger vs. safety. Infectious encephalopathies are accompanied by a failure of adaptive immunity and an impaired immune capacity to differentiate internal danger vs. safety. All three conditions are associated with impairments to differentiate danger vs. safety and adapt effectively. There are reciprocal interactions between ACE, PTSD, and infectious encephalopathies with accompanying persistent immune activation. This is associated with immune dysregulation, chronic hyperarousal, activation of the stress response, and impairments of the fear recognition and response neural circuits, hypothalamic–pituitary–adrenal axis, amygdala, and hippocampus. The pathophysiological processes can result in a broad spectrum of chronic neuropsychiatric and somatic symptoms and diseases. Understanding the psychodynamic, neurological, neuroimmune, inflammatory and autoimmune components of this interactive process expands the effective treatment opportunities.
Electrocardiographic abnormalities with quinine and artesunate combinations in comparison to quinine or artesunate alone in severe falciparum malaria

Field: Medicine (Health Sciences)

Background: In Multi drug resistant falciparum malaria anti-malarial combinations are frequently used i.e. Quinine and IV Artesunate. Quinine is associated with electrocardiographic disturbances. Artesunate in high dose produce QTC prolongation in animal models, so the electrocardiogram (ECG) is thoroughly studied.Methods: Severe falciparum malaria cases 15 to 60 years were randomly allocated into 3 treatment regimens i.e. Artesunate, Quinine alone and their combination. Electrocardiographic recordings were taken periodically in 3 groups and compared statistically.Results: The mean QTC interval is significantly prolonged in combination treatment group from 0.40+0.02 to 0.49+0.09 (P<0.05) ECG disturbance (44%). QTC prolongation was commonest (i.e. 27%) with electrolyte imbalance could produce life threatening cardiac arrhythmia (Polymorphic VT with Sr K+ 2.9). Artesunate alone was list prone (i.e. only 6%) Quinine though has comparatively more (i.e. 25%) but there is no life-threatening cardiac arrhythmia in artesunate and Quinine.
Novel Structures for High Confinement in Sub-Wavelength Regions

Field: Physics and Astronomy (Physical Sciences)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Lipson, J. T. Robinson, Q. Xu, V. Almeida, and H. Lipson, "Novel structures for high confinement in sub-wavelength regions," in Integrated Photonics Research and Applications/Nanophotonics for Information Systems, Technical Digest (Optica Publishing Group, 2005), paper NWB1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Chlorine Efficiency in the Reducing Coliforms in the Sanitary Effluent of Septic Tank Treatment Systems with Anaerobic Filter

Field: Environmental Science (Physical Sciences)

The lack of basic sanitation is still a problem in Brazil, only about half of all sewage produced undergoes treatment, due to difficulties in introducing sanitary effluent treatment plants considering that most Brazilian cities do not have financial resources for implementation and maintenance of these stations. In this way, many cities have been adopting different methods for treating sewage before discarding into the rain network. Thus, this work aimed to analyze the efficiency of chlorine in the reduction of coliforms in the sanitary effluent of a treatment system with septic tank, anaerobic filter and disinfection. Six sanitary sewage treatment systems were evaluated from different condominiums from august to december 2019. To check its efficiency, the following parameters were analyzed: pH, thermotolerant coliforms, free residual chlorine and chemical oxygen demand (COD). The results showed that of the six stations evaluated, only one (16,78%) presented the amount of thermotolerant coliforms within the permissible standards. Furthermore, of these only three stations (50%) presented the concentrations of free residual chlorine according to the required parameters. In addition, COD was high at four (66,66%) of the analyzed stations. These data allow us to conclude that the efficiency of chlorine in the reduction of coliforms in the sanitary effluent from a septic tank treatment system, anaerobic filter and disinfection unfortunately may not be happening, because this type of system needs to be well operated and inspected frequently, since the operation is mostly done by users.
Robust controllers for the Middeck Active Control Experiment using Popov controller synthesis

Field: Engineering (Physical Sciences)

The purpose of this paper is to demonstrate robust compensators designed using Popov controller synthesis on the Middeck Active Control Experiment (MACE): a Shuttle program scheduled for flight in January, 1995. The experiment has been designed to investigate the extent to which the on-orbit behavior of a precision-controlled spacecraft can be predicted and controlled using analysis and ground testing prior to launch. Previous flight experiments indicate that, on-orbit, the structural dynamics can change significantly, and that these changes are very difficult to predict. Thus the need arises for robust control techniques that can guarantee on-orbit performance for flexible spacecraft even though the models have large parameter uncertainties. Such a technique is developed in this paper using the Popov stability criterion from absolute stability theory. A state space representation of the stability analysis test is combined with an /spl Hscr//sub 2/ performance objective to provide a powerful technique for robust controller synthesis. A numerical algorithm for optimizing the controller gains and stability multipliers is discussed. Several experimental results on MACE are used to demonstrate that Popov controller synthesis guarantees robustness to real parameter variations and yields good performance with respect to the reference LQG designs.< >
3D game development cube-it : front-end web app development

Field: Computer Science (Physical Sciences)

Websites are used all over the world. It is one of the most common forms of interactive media that is usually used by companies and individuals to share information.These information can range from background of a company, to how an item can be purchased. A website is very important, especially in this technologically advanced world today. When a piece of information is required, people tend to look up the Internet to search for what they need. This means that a website is often the initial point of contact one will have with the company or individual behind the website. As such, the website will be creating the very first impression one will have towards the owner of the website. Leaving a positive and lasting impression is especially important when it comes to websites for startups, just like Cube-It – a joining device and system which can be used in many areas. As new products usually begin relatively unknown, building up a good reputation is extremely important so as to garner interest and create business opportunities. Hence, developing the Cube-It website required in-depth planning and thought process.
Islamic green finance

Field: Business, Management and Accounting (Social Sciences)

This chapter looks at Islamic green finance as a significant market innovation both in the light of environmental sustainability and Shari'ah standards for Islamic financial institutions. To this aim, the work is divided into two parts. Part One outlines the Islamic tradition on environmental protection, its principles, precepts and key institutes. Part Two focuses on contemporary Islamic economics and finance. By reviewing the research agenda on Islamic economics, it remarks how green sukuk and awqaf can contribute to sustainable development, and suggests improvements in Shari'ah-compliance criteria for green economy objectives to be implemented in Islamic finance.
Drainage Along Swamp Forest Roads Lessons from Northern Europe

Field: Environmental Science (Physical Sciences)

Abstract Wetland road crossings, especially in peatlands of the boreal forests of the United States and Canada, frequently show patches of dead or low-vigor timber on the upper side of the road. The condition is caused by failure to provide for adequate cross-drainage, with a resulting rise in the level of the water table and drowning out of the timber. The chief problems are lack of a collector ditch on the upper side of the road, culverts set too high, and lack of a discharge ditch on the opposite side of the road. An example is given of proper installation of these road drainage facilities on a forest road in Finland, along with a discussion of the hydrological fundamentals of good and poor provisions for cross-drainage.
The Burden of Hypertensive Disorders of Pregnancy (HDP) on Perinatal Outcome and Caesarean Delivery at Tertiary Care Hospital, Bhubaneswar- a Prospective Correlational Study

Field: Medicine (Health Sciences)

HDPs are a major concern for mother and child challenging the advanced medical facility due to Increased maternal and newborn mortality with high incidences of cesarean delivery. A prospective observation was conducted using correlational model to investigate the impact of HDP on both maternal and neonatal outcome and the rate of cesarean section among women at tertiary care center of Bhubaneswar with sample of 150. Data analysed using SPSS version 20. The result shows that 15% of women had chronic hypertension, 52% were diagnosed with gestational hypertension (GHTN) or pregnancy induced hypertension (PIH), 21% has preeclampsia (PE) and 9% had eclampsia (E). Also the women suffering with superimposed PE/ Severe PE and eclampsia is 5%. The data on maternal outcome reveals that total 68% of women presented with complications due to PIH and major type of complications were Endocrine related (27%), hypertension related (12%) and others were 29%. Similarly the data on newborn outcome shows that 16% of baby has fetal distress after delivery and 14% needed resuscitation. Total 11% babies were IUGR, 37% babies admitted to ICU due to complication and 10% of baby died out of complication secondary to PIH. Again the data on type of delivery shows that maximum (59%) women underwent emergency cesarean section and 19% has planned C section. And only 20% of women had delivered by vaginal delivery. PIH is one of the leading cause for adverse maternal and newborn outcome including mortality and also it is contributing to highest rate of cesarean delivery.
The charging pattern for Cheng-Mian-Le passenger transportation line

Field: Computer Science (Physical Sciences)

The new automatic charge pattern using IC card is designed to facilitate prospective customers of Chen-Mian-Le passenger transportation line. Firstly, the paper proposed this new pattern's overall structure, the theories and methods on how to fulfill its functions. Secondly, the paper designed concerned models in the B/S structure and examined the pattern's functions, such as the creation of a passenger ID account with boarding card, in- advance charge storing, seats allocation, trip labels recording, travelling distance calculation, and fares charging in the database. Finally, the paper verified the feasibility and convenience of the new toll collection model.
Current Status of Laparoscopic and Robotic Pancreatic Surgery and Its Adoption in Singapore

Field: Medicine (Health Sciences)

Despite the potential clinical advantages offered by laparoscopic pancreatic surgery (LPS), the main obstacle to its widespread adoption is the technically demanding nature of the procedure and its steep learning curve. LPS and robotic pancreatic surgery (RPS) have been proven to result in superior short-term perioperative outcomes and equivalent long-term oncological outcomes compared to the conventional open approach, with the caveat that they are performed by expert surgeons who have been trained to perform such procedures. The primary challenge faced by most pancreatic surgeons is the steep learning curve associated with these complex procedures and the need to undergo surgical training, especially with regards to laparoscopic and robotic pancreaticoduodenectomy. Current evidence suggests that RPS may help to shorten the lengthy learning curve required for LPS. More robust evidence—in the form of large randomised controlled trials—is needed to determine whether LPS and RPS can be safely adopted universally. Ann Acad Med Singapore 2020;49:377–83 Key words: Laparoscopic pancreatectomy, Laparoscopic pancreaticoduodenectomy, Minimally invasive pancreatic surgery, Robotic pancreatectomy, Robotic pancreaticoduodenectomy
Associated data of Time resolved dosimetry for QAQC in Pencil Beam Scanning

Field: Medicine (Health Sciences)

- Center_Markus_E9_10mm_20201111_2.csv : Dataset for Fig 5, 6- 2DUniform_Markus_10mm_(0,0).csv : Dataset for Fig. 7 and 8- result_2DUniform_Markus_10mm_(0,0).csv.root.txt : Dataset for Fig. 9- ROOTDATA_FIG_2DUniform_Markus_E8_135.5mm.csv.root : Dataset for Fig. 10- LineProfile_calc_meaured_comp_10mm.csv : Dataset for Fig. 11
Trends in anthropogenic CO 2 in water masses of the Subtropical North

Field: Environmental Science (Physical Sciences)

The variability in the storage of the oceanic anthropogenic CO2 (Cant) on decadal timescales is evaluated within the main water masses of the Subtropical North Atlantic along 24.5N. Inorganic carbon measurements on five cruises of the A05 section are used to assess the changes in Cant between 1992 and 2011, using four methods (DC ⁄ , TrOCA, uCT 0 , TTD). We find good agreement between the Cant distribution and storage obtained using chlorofluorocarbons and CO2 measurements in both the vertical and horizontal scales. Cant distribution shows higher concentrations and greater decadal storage rates in the upper layers with both values decreasing with depth. The greatest enrichment is obserbed in the central water masses,
Problems in the use of antibiotics in our hospital and countermeasures

Field: Health Professions (Health Sciences)

In order to identify problems in the use of antibiotics and propose corresponding countermeasures, a statistical analysis was made into 6 000 prescriptions and medical records detailing the use of antibiotics by outpatients and inpatients randomly selected from the years 2002～2003. It was found that the irrational use of antibiotics was prevalent. It is pointed out that high attention ought to be paid to the issue and countermeasures be adopted, including strengthening physician training in the three basics, implementing various rules and regulations, adhering to the standards and guides for the use of antibiotics, dynamically tracing the use of antibiotics by means of the computer, and providing timely analysis and feedback of information on the use of antibiotics.
Map of the Tern Islands study area in Kouchibouguac National Park, New Brunswick.

Field: Earth and Planetary Sciences (Physical Sciences)

<p>Light gray areas represent intertidal zones (figure adapted from Craik and Titman [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0122588#pone.0122588.ref023" target="_blank">23</a>]).</p>