jimnoneill/paper-to-field-training huggingface dataset:
The clinical significance of the expression of E-cd and EGFR proteins in supraglottic carcinoma

Field: Medicine (Health Sciences)

Objective:To study the expression and clinical significance of E-cadherin (E-cd) and epidermal growth factor receptor (EGFR) proteins in supraglottic carcinoma. Methods: Using LSAB-immunohistochemical technique, the expression of E-cd and EGFR proteins were investigated in 54 cases of human supraglottic squamous cell carcinoma. Results: The rate of expression was 44.4% in the E-cd(E-cd~+)and 53.7% in the EGFR(EGFR~+),they significantly correlated with TNM stages, invasive extent, lymph node metastasis and degree of differentiation(P0.01 or P0.05). The 5-year cumulative survival rate was 94.29% in the E-cd~+ cases, 61.53% in the E-cd~-negative cases(E-cd~-),94.74% in the EGFR~-negative cases(EGFR~-), 59.06% in the EGFR~+ cases, with significant difference(P0.01). The prognosis was significantly poor in E-cd~-EGFR~+ subjects: the 5-year cumulative survival rate was 100.00% in the E-cd~+EGFR~- cases, while it was 55.03% in the E-cd~-EGFR~+ cases(P0.01). Four of five occult lymph node metastasis(cN~-pN~+)were E-cd~-EGFR~+. Conclusion: These findings suggest that the immunohistochemical determination of expression of E-cd and EGFR proteins in supraglottic carcinoma can be used as the predictors of tumor invasion, lymphatic metastasis and prognoses. If combining them, a more precise prognosis can be obtained. Such a combined technique may be very useful as an indicator for grading the biological malignancy of laryngeal cancer.
Addition Polymerization of Ethylene Oxide with p-Dodecylbenzenesulfonamide and Surface Activities of the Products

Field: Chemistry (Physical Sciences)

長鎖芳香族スルホンアミドとエチレンオキシドとの反応およびその生成物の諸物性の内容については余り知られていないので,これらを明らかにするために本研究を行なつた。p-ドデシルベンゼンスルホンアミドとエチレンオキシドとを反応させて,生成物をシリカゲルを充テンしたカラムクロマトグラフ法で分別した。これらの分別試料について,薄層クロマトグラフィー,赤外吸収スペクトルおよび核磁気共鳴スペクトル分析を行ない,各試料の化学構造を推定した。ついで各試料水溶液の比重,表面張力,乳化,可溶化,分散およびぬれ剤のテストを行なった結果,これら試料はかなりの界面活性を示し,乳化剤,可溶化剤およびぬれ剤としてすぐれていることが明らかとなった。
About porosity of some Świątkowski functions in the space of quasi-continuous functions

Field: Mathematics (Physical Sciences)

In the paper by M. Filipczak, G. Ivanova and J. Wódka, Comparison of some families of real functions in porosity terms, Math. Slovaca 67(5) (2017), 1155–1164, it was proved that the family of quasi-continuous Świątkowski functions is porous but not strongly porous in the space of quasi-continuous functions. We improved this result. We found the unique number q = 2/3 such that the family of quasi-continuous Świątkowski functions is lower q-porous in this space.
Preventing tetanus in adults in general practice.

Field: Health Professions (Health Sciences)

Tetanus statistics in England and Wales are quoted to show the desirability of widening the population to whom tetanus immunisation is offered. Yhr inclusion of a health educationalist in the general-practitioner team to achieve this is advocated. Methods of obtaining an increased acceptance of immunisation by waiting-room education alone, by waiting-room education with general-practitioner involvement, and by general-practitioner involvement alone were explored and are discussed.
Early Career Psychiatrists in Europe During COVID-19 Outbreak: Results of The EPA ECPC-EFPT Cross-Sectional Survey

Field: Medicine (Health Sciences)

Abstract Body The COVID-19 pandemic has affected the lives and work of Early Career Psychiatrists (ECPs). Some had to revamp their professional life, start using telepsychiatry without prior training, change their workplace during the pandemic, or were quarantined. Others were not able to complete their training or take obligatory courses as planned. The aim of the study was to understand the impact of the pandemic on education and professional development, working conditions and wellbeing of ECPs, as well as their attitude to telepsychiatry. The anonymous, 24-question cross-sectional survey was conducted by the European Psychiatric Association Early Career Psychiatrists Committee (EPA ECPC) and the Task Force on Meetings and Associations with the collaboration and support of the European Federation of Psychiatric Trainees (EFPT). 517 participants from 39 different countries (member states of the Council of Europe) have been included in the analysis. Statistical analyses have been performed. Final results will be presented during the symposium. Identifying the impact of the COVID-19 pandemic on ECPs will help us better prepare for similar events in the future, equip them with the necessary skills and provide them with the right support. Disclosure No significant relationships.
Special Section: Defining and Measuring “Recovery” Commentary on “Defining and Measuring ‘Recovery&apos;”

Field: Social Sciences (Social Sciences)

overdue step to develop an operational definition of recovery. Without a starting point, the public and policymakers will remain uninformed about the number of people in long-term recovery, the pathways that they took, and the opportunities to make it possible for even more people to experience new lives, free from addiction. Although individuals and family members have experienced and can articulate what it has meant to reclaim dignity and respect for themselves and from their community through their recovery, the public and many policymakers remain in the dark. For people looking into communicating with the public about the reality and issues of recovery, the word recovery must be defined. In a report on its April 2004 survey of the general public conducted for Faces and Voices of Recovery, Peter D. Hart Research Associates/Coldwater Corporation (2004) found that “[t]he public does not know what ‘recovery ’ means. ” When asked what definition best matches their understanding of someone “in recovery from addiction to alcohol or other drugs, ” most (62%) said that it means the person is currently trying to stop using alcohol or illicit drugs. Only 22 % said that the person in recovery is free from the disease of addiction and no longer uses alcohol or illicit drugs. Even those who know someone in recovery overwhelmingly (62%) believe that someone in recovery is “trying to stop using alcohol or drugs.”
Synthetic Sensor Measurement Generation With Noise Learning and Multi-Modal Information

Field: Computer Science (Physical Sciences)

Deep learning has transformed data generation, particularly in creating synthetic sensor data. This capability is invaluable in fields like autonomous driving, robotics, and computer science. To achieve this, we train models using real data, enabling them to replicate sensor data closely. These models introduce variations and noise, enhancing diversity and realism. Prominent techniques, including generative adversarial networks (GANs), variational autoencoders (VAEs), and recurrent neural networks (RNNs), excel in generating synthetic sensor data. Our paper focuses on Autoregressive Convolutional Recurrent Neural Networks (CRNN) for Multivariate Time Series Prediction. We incorporate Denoising Autoencoders (DAE) to mimic real-world noise characteristics. Our model is trained and validated using Ultra Wide Band (UWB) and Ultra High-Frequency Radio Frequency Identification (UHF-RFID) sensor data. It integrates sensor measurements and diverse information sources to produce synthetic data complementing real-world data. While demonstrated with UHF-RFID and UWB sensors, these techniques extend to industrial automation, healthcare and environmental monitoring. While our methodology exhibits broad potential, we present practical demonstrations with UHF-RFID and UWB sensors. Our deep neural network model allows researchers to construct datasets for algorithm validation, eliminating the need for costly and time-consuming data collection.
植物光合CO2响应模型对光下(暗)呼吸速率拟合的探讨

Field: Agricultural and Biological Sciences (Life Sciences)

运用LI．6400便携式光合作用系统测定了不同光强（2000、1500、1000和500μmol·m-2·s-1）70N种02浓度（21％702％的02）下冬小麦（Triticumaestivum）灌浆期旗叶的C02响应曲线，比较了现有C02响应模型（生化模型、直角双曲线模型和直角双曲线修正模型）拟合给出光下（暗）呼吸与测量值之间的差异。结果显示，直角双曲线修正模型所给出的光下呼吸速率拟合值与测量值最为接近。植物光合作用对大气C02响应U／ca）的拟合结果优于光合作用对胞间C02浓度（A／G）的拟合。然而，所有模型基Y-A／Ca拟合的光下（暗）呼吸在整体上与测量值存在显著差异p〈0．05），推测与现有模型没有考虑C02浓度对光呼吸和光下暗呼吸速率的影响有关。对小麦的试验结果表明，C02浓度对光呼吸和光下暗呼吸均有显著影响：随着C02浓度的增加（0-1400μmol·moF’），不同光强下的表观光呼吸变化范围分别为5．035—11．670、4．222—11．650、4．330-10．999和3．263-9．094gmolC02．m-2·s-。；光下暗呼吸的变化范围分别为0．49l-2．987、0．457-2．955、0．545—3．139和0．448-3．139gmolCO2m-2·s-1。回归分析发现，表观光呼吸和光下暗呼吸与C02浓度之间均存在较好的相关性。然而，将该回归关系整合到现有模型中，是否会优化模型，从而提高模型对相关光合参数估算的准确性尚有待于进一步研究。
Effect Factors of Benzene Adsorption and Degradation by Nano‐TiO2 Immobilized on Diatomite

Field: Environmental Science (Physical Sciences)

Difference between adsorption of benzene by diatomite and nano‐TiO 2 immobilized on diatomite was investigated. And effects of temperature, light intensity, relative humidity, and initial benzene concentration on adsorption and degradation of benzene by nano‐TiO 2 immobilized on diatomite were also studied. The experimental results showed that when initial benzene concentration was 2.2 × 10 −3 mg L −1 , it could be degraded to below safe concentration (1.1 × 10 −4 mg L −1 ) after 50 h when temperature was 20°C, but it just needed 30 h at 35°C. When light intensity was 6750 Lx, it needed 30 h for benzene to be degraded to below safe concentration, but benzene could barely be degraded without light. When relative humidity was 50%, benzene could be degraded to 1.0 × 10 −4 mg L −1 after 30 h, while its concentration could be reduced to 7.0 × 10 −5 mg L −1 at the relative humidity of 80%.
All-<i>cis</i> Saturated 2,5-Diketopiperazines\nby a Diastereoselective Rhodium-Catalyzed Arene Hydrogenation

Field: Chemistry (Physical Sciences)

The direct hydrogenation\nof aromatic systems is a compelling tool\nto access saturated carbo- and heterocycles, an omnipresent motif\nin natural products, pharmaceuticals, and agrochemicals. Although\na variety of methods have been established for simple arenes, the\nselective hydrogenation of aromatic 2,5-diketopiperazines (2,5-DKPs)\nhas not been explored. We herein report a modular approach to perform\na highly diastereoselective arene hydrogenation of symmetric 2,5-DKPs\ncatalyzed by a rhodium complex. Twenty-eight saturated pentacyclic\n2,5-DKPs were obtained in high yields with exquisite diastereoselectivities,\nexhibiting the hydrogen atoms in an all-cis arrangement. The high\ntolerance toward functional groups and the compatibility with existing\nstereogenic centers are key features of the transformation.
The Prediction of Acute Response, Remission and General Outcome of Neuroleptic Treatment in Acute Schizophrenic Patients*

Field: Medicine (Health Sciences)

The prognosis of a clinical neuroleptic treatment was prospectively examined in 26 schizophrenic patients using a predetermined set of predictors and outcome criteria. Prognosis before treatment did not discriminate significantly between patients with good and poor outcome. Significant differences of outcome were observed between the prognostic groups, if prognosis was established after 5 days of treatment. Retrospective analysis of individual predictors indicated the following rank order: initial improvement, age, duration of symptoms before treatment, sex, subjective tolerance of the treatment. The relative weight of the individual predictor in forming the prognosis is still an open question.
Food insecurity, food "deserts," and glycemic control in patients with diabetes: A longitudinal analysis

Field: Medicine (Health Sciences)

OBJECTIVE Both food insecurity (limited food access owing to cost) and living in areas with low physical access to nutritious foods are public health concerns, but their relative contribution to diabetes management is poorly understood. RESEARCH DESIGN AND METHODS This was a prospective cohort study. A random sample of patients with diabetes in a primary care network completed food insecurity assessment in 2013. Low physical food access at the census tract level was defined as no supermarket within 1 mile in urban areas and 10 miles in rural areas. HbA1c measurements were obtained from electronic health records through November 2016. The relationship among food insecurity, low physical food access, and glycemic control (as defined by HbA1c) was analyzed using hierarchical linear mixed models. RESULTS Three hundred and ninety-one participants were followed for a mean of 37 months. Twenty percent of respondents reported food insecurity, and 31% resided in an area of low physical food access. In adjusted models, food insecurity was associated with higher HbA1c (difference of 0.6%[6.6mmol/mol], 95% CI 0.4-0.8[4.4-8.7],P<0.0001), which did not improve over time (P = 0.50). Living in an area with low physical food access was not associated with a difference in HbA1c (difference 0.2%[2.2mmol/mol], 95% CI 20.2 to 0.5 [22.2 to 5.6], P = 0.33) or with change over time (P = 0.07). CONCLUSIONS Food insecurity is associated with higher HbA1c, but living in an area with low physical food access is not. Food insecurity screening and interventions may help improve glycemic control for vulnerable patients.
Hyperosmotic modulation of the cytosolic calcium concentration in a rat osteoblast‐like cell line.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

1. The effects of hyperosmotic stress on cytosolic calcium concentration ([Ca2+]i) were studied by ratio image analysis in single cells of an osteoblast‐like bone cell line (RCJ 1.20) loaded with fura‐2 AM. 2. The ratio (340 nm/380 nm) of steady‐state [Ca2+]i in resting osteoblasts kept in Hepes‐buffered medium was 0.82 +/‐ 0.04. A hyperosmotic stimulus (200 mosmol l‐1 sucrose) produced a [Ca2+]i transient with a peak ratio of 1.28 +/‐ 0.09, which decayed with an apparent half‐life (t1/2) of 42.7 +/‐ 2.6 s. 3. The hyperosmotically induced [Ca2+]i transients were insensitive to verapamil, diltiazem or nifedipine, which excludes the involvement of dihydropyridine‐sensitive Ca2+ channels in the process. Non‐specific Ca2+ channel blockers (Mn2+, Ni2+, La3+ or Gd3+) partially abolished the hyperosmotically induced [Ca2+]i elevation, indicating the contribution of extracellular Ca2+ influx. 4. A hyperosmotic stimulus applied in Ca(2+)‐free medium (0.5 mM EGTA) lowered the [Ca2+]i peak to a ratio of 0.96 +/‐ 0.08 (P < 0.001) compared with a Ca(2+)‐containing medium. This suggests that the [Ca2+]i increase is due to extracellular influx, as well as release from an intracellular Ca2+ pool. 5. Application of thapsigargin (0.5 microM), a specific inhibitor of endoplasmic reticulum Ca(2+)‐ATPase, in Ca(2+)‐free medium caused transient [Ca2+]i elevation to peak ratios of 1.33 +/‐ 0.09, and completely abolished the [Ca2+]i response to a hyperosmotic stimulus. This implies the existence of a thapsigargin‐sensitive intracellular pool of Ca2+ that is mobilized by hyperosmotic stimulus.(ABSTRACT TRUNCATED AT 250 WORDS)
Cognitive decline in dementia with Lewy bodies: a 5-year prospective cohort study

Field: Medicine (Health Sciences)

Objectives We report the cognitive decline in persons diagnosed with mild dementia with Lewy bodies (DLB) and mild Alzheimer's disease (AD) during 5 years of annual follow-ups. Methods Patients were recruited into the study from geriatric, psychiatric and neurology clinics in Western Norway during 2005–2013. They were diagnosed according to clinical consensus criteria, based on standardised clinical rating scales. Autopsy-based diagnoses were available for 20 cases. Cognitive decline for up to 5 years was assessed using the Clinical Dementia Rating (CDR) scale and the Mini-Mental State Examination (MMSE). Survival analysis including Cox regression (time to reach severe dementia) and linear mixed-effects (lme) modelling were used to model the decline on MMSE. Results At least one follow-up assessment was available for 67 patients with DLB and 107 patients with AD, with a median follow-up time of 4.3 years. The time to reach severe dementia was significantly shorter in DLB (median 1793 days) compared with AD (1947 days; p=0.033), and the difference remained significant in the multiple Cox regression analysis (HR=2.0, p<0.02). In the adjusted lme model, MMSE decline was faster in DLB (annual decline 4.4 points) compared with AD (3.2 points; p<0.008). Conclusions Our findings show that from the mild dementia stage, patients with DLB have a more rapid cognitive decline than in AD. Such prognostic information is vital for patients and families and crucial for planning clinical trials and enabling health economic modelling.
Character Education Analysis in The Natural Sciences Textbook of 9th Grade (Student Book): a Case of Chemistry Subject

Field: Arts and Humanities (Social Sciences)

Education is not only to develop cognitive aspects but also to develop the character of a human being. As one of the primary learning sources, the textbook also has to accommodate character education. This study aimed to analyze character education in chemistry subject in the natural sciences textbook of 9th Grade, especially student book. The textbook that was analyzed was published by the Ministry of Education, Culture, Research, and Technology. The study was conducted by a qualitative method using the content analysis technique. Two chapters are analyzed. Particles Composing Objects and Living Things and Eco-friendly Technologies. The study revealed that these two chapters contained all values of Basic Competencies 3 and 4 in Curriculum 2013 (religious, care, responsibility, discipline, honesty, confidence, communicative, creative, scientific thinking, curiosity, democratic, and collaboration).
Construction ofNanocellulose Aerogels with EnvironmentalDrying Strategy without Organic Solvent Displacement for High-EfficiencySolar Steam Generation

Field: Materials Science (Physical Sciences)

Solar desalination is one of the effective means to alleviate water scarcity, in which aerogel-like evaporators have attracted extensive attention in the field of efficient desalination. However, the current preparation methods for aerogels still mainly rely on high-cost solutions, such as freeze-drying or supercritical drying. Herein, a preparation scheme for aerogels that can be realized under atmospheric pressure conditions is reported. In this paper, a foam skeleton template (FST) strategy is proposed, in which flake graphite is entangled by cellulose nanofibers (CNFs) and codispersed between the foam cell walls, and subsequently connected with the nascent Ca2+ in the inner wall to form a tough and stable three-dimensional network structure, which can effectively avoid the structural collapse caused by atmospheric drying. The cellulose/graphite aerogel (CGA) prepared using the FST strategy possesses lightweight (36 mg cm–3) and porous (porosity >97%) properties. The 3D porous structure and wetting characteristics of the CGA provided excellent energy management, rapid water transport capability, and a reduced enthalpy of evaporation, which enabled it to achieve a fast water evaporation rate of 3.8 kg m–2 h–1 with 98.4% energy efficiency. This FST strategy provides a solution for the low-cost development of aerogel and desalination.
Laser Fundamental Principles

Field: Physics and Astronomy (Physical Sciences)

Light Amplification by Stimulated Emission of Radiation (Laser) is light with specific properties and may interact with tissues and materials. Physically seen, the change of energy levels of electrons in an atom produces the laser radiation. With the term laser is identified a physical principle leading to the production of electromagnetic radiation, which differs from the usual light in the following properties: coherence, collimation, and monochromatism. From the practical standpoint, a laser device contains the following components: the laser medium, the optical resonator, and the laser pumping mechanism. The laser beam is used as a handpiece by means of different guide systems, allowing the surgeon to perform a perfect, with minimal complications, and practical, laser application. The fiber-based delivery system offers the advantages of tangential cutting and office-based applications, because the laser energy is not delivered in a "line-of-sight" mode.
ISLAMIC CLAY FIGURINES FROM EXCAVATIONSAT ISTAKHR ANDA SUGGESTED USE OF THE ANIMAL-SHAPEDSPECIMENS

Field: Arts and Humanities (Social Sciences)

This paper deals with the Islamic hand-modelled clay figurines from the excavations carried out at Istakhr (Fars region, Iran) by the Oriental Institute of Chicago in the 1930s and the Joint Italian-Iranian Archaeological Mission in 2012.S. Mancini presents detailed descriptions of these artefacts, including some technological notes relatingto fabrics, as well asa few comparisons help to propose theirchronological attribution.M.V. Fontana suggests that the animal specimens can be understood as figurines which children usually placed on the roofs of their houses pending the end of panjī-masand to welcome in the New Year at the end of a long-lasting ritual of Zoroastrian tradition, as can also be seen in some Seljuk glazed ceramic “house models”
Initial therapy with FOLFOXIRI plus bevacizumab (bev) for RAS mutant metastatic colorectal cancer (mCRC) and gene mutations in circulating tumor DNA (ctDNA) as a predictive marker for the efficacy: JACCRO CC-11.

Field: Medicine (Health Sciences)

635 Background: We have reported that modified (m)-FOLFOXIRI plus bev was feasible and had a good objective response rate (ORR) for Japanese patients (pts) in a phase II trial of the JACCRO CC-11 (ESMO 2017 #543P). In addition, a pre-planned research was performed to investigate if the change of gene mutations in ctDNA during therapy can serve as a predictor for clinical outcomes in RAS mutant mCRC. Methods: The efficacy of m-FOLFOXIRI (irinotecan 150 mg/m², oxaliplatin 85 mg/m², levofolinate 200 mg/m², and fluorouracil 2400 mg/m² repeated biweekly) plus bev was evaluated prospectively in 62 pts (median age 63, 55% male, 92% PS0, and 27% right-sided tumors) with mCRC harboring RAS mutation (mt). The primary endpoint was ORR. Progression-free survival (PFS), overall survival, early tumor shrinkage (ETS), depth of response (DpR), and safety were secondary endpoints. Plasma samples for extraction of ctDNA were collected at 3 points (pre-, 8w, and progression) and analyzed for specific KRAS, NRAS, BRAF, and PIK3CA variants with real-time PCR assays. Results: Updated median follow-up time was 10.2 months. ORR and disease control rate were 75.8% and 96.8%, respectively. ETS was 73.8%, and median DpR was 49.6%. Median PFS was 11.5 months (95%CI 9.5-14.0). KRAS/ NRAS mt from pre-treatment plasma was confirmed in 79% of pts. In 41 pts with RAS mt at pre-treatment, mt status at 8 weeks predicted clinical outcomes (Table). Moreover, combined assessment of mt in ctDNA and ETS served as a refined predictor for efficacy. Pts with PIK3CA mt at pre-treatment had a poor outcome (ORR, 43%; median PFS, 8.8 months). Conclusions: FOLFOXIRI plus bev regimen is active for RAS mutant mCRC. RAS mt in ctDNA and ETS evaluation might potentially be a useful on-treatment biomarker in mCRC pts with RAS mt. Clinical trial information: UMIN000015152. [Table: see text]
Eviota bacata, a new dwarfgoby (Teleostei: Gobiidae) from New Caledonia

Field: Agricultural and Biological Sciences (Life Sciences)

A new species of dwarfgoby, Eviota bacata n. sp., is described from New Caledonia in the South Pacific Ocean. The new species is characterized by a cephalic sensory-canal pore system lacking only the IT pore (pattern 2); a dorsal/anal-fin formula of 7/7; pectoral-fin rays unbranched; the fifth pelvic-fin ray 20% of length of the fourth ray; the abdomen with black peritoneum clearly visible externally and with a yellow-white stripe along the dorsal portion and a row of distinctive round white spots on the ventral portion; and a vertically elongated black mark at the top of the pectoral-fin base. The species is most similar to Eviota atriventris.