jimnoneill/paper-to-field-training huggingface dataset:
Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

In this study we analysed the function of the Meinox gene prep1.1during zebrafish development. Meinox proteins form heterotrimeric complexes with Hox and Pbx members, increasing the DNA binding specificity of Hox proteins in vitro and in vivo. However, a role for a specific Meinox protein in the regulation of Hox activity in vivo has not been demonstrated. In situ hybridization showed that prep1.1 is expressed maternally and ubiquitously up to 24 hours post-fertilization (hpf), and restricted to the head from 48 hpf onwards. Morpholino-induced prep1.1 loss-of-function caused significant apoptosis in the CNS. Hindbrain segmentation and patterning was affected severely, as revealed by either loss or defective expression of several hindbrain markers (foxb1.2/mariposa, krox20, pax2.1 and pax6.1), including anteriorly expressed Hox genes(hoxb1a, hoxa2 and hoxb2), the impaired migration of facial nerve motor neurons, and the lack of reticulospinal neurons (RSNs)except Mauthner cells. Furthermore, the heads of prep1.1 morphants lacked all pharyngeal cartilages. This was not caused by the absence of neural crest cells or their impaired migration into the pharyngeal arches, as shown by expression of dlx2 and snail1, but by the inability of these cells to differentiate into chondroblasts. Our results indicate that prep1.1 has a unique genetic function in craniofacial chondrogenesis and, acting as a member of Meinox-Pbc-Hox trimers, it plays an essential role in hindbrain development.
Sedimentation behavior of protein solutions in ultracentrifugation field.

Field: Chemistry (Physical Sciences)

An analytical ultracentrifluge was used to characterize the behaviors of ultracentrifugal sedimentation of bovine serum albumin solutions. We obtained data both for the sedimentation velocity and for the growth rate of the sediment that accumulates during ultracentrifugation. Effects of the rotor speed, the solution concentration, and the volume of the solution contained in the cell on the sedimentation behaviors were investigated experimentally. The sedimentation behaviors and the properties of the compressible sediment were explained well in terms of the theory which has been applied with respect to particulate suspension. Finally, it was shown that such factors of the solution environment as the solution pH and the salt concentration have a large effect on the sedimentation behaviors.
Advancing Retention and Engagement Strategies Through Effective Online Mediums

Field: Social Sciences (Social Sciences)

Historically Black Colleges and Universities in the USA continue to play a pivotal role in educating students within the African diaspora as they provide a practical and resourceful platform for students to develop a sense of belonging through community and organizational outreach activities on campus. However, the student population in higher education as we used to know has changed, and adult learners now make up a large majority of the enrolled population. This chapter aims to review the history of online education and will provide a conceptual framework for incorporating online learning in an institution's student success plan for both their traditional and non-traditional students. The author will also review the needs of the adult learners and provide an overview of how the development and integration of online learning programs and collaborative efforts with other institutions through dual enrollment and degree MOU programs can foster growth at Historically Black Colleges and Universities.
Characterization of the Metrnl Serum Levels in Patients with Inflammatory Bowel Disease and its Association with Inflammatory Cytokines

Field: Medicine (Health Sciences)

Abstract

Background Meteorin-like (Metrnl) is a newly discovered adipokine with the anti-inflammatory and insulin sensitizing properties. Accordingly, Metrnl regulates glucose tolerance, enhances metabolism in body tissues, and induces thermogenesis in white adipose tissue. However, the correlation among Metrnl, IBD, and obesity still remains unexplored. Methods The present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn's disease (CD) patients who were diagnosed by pathological examination. In these patients, serum levels of adiponectin, Metrnl, IL-6, and TNF-α were measured using ELISA kits. Results Metrnl concentration significantly decreased in both of the UC (85.25 ± 36.55 pg/mL) and CD (76.93 ± 27.92 pg/mL) patients compared to control group (107.52 ± 35.33 pg/mL). Similarly, adiponectin has also decreased in these two patient groups compared to the controls. However, IL-6 and TNF-α significantly increased in both of the patient groups. Moreover, Metrnl indicated an inverse relationship with BMI in the controls and both of the patient groups. In addition, there was an inverse correlation among Metrnl, IL-6, and TNF-α in both of the patient groups. Conclusions The current study is the first one reporting the decreased Metrnl serum level in the patients with IBD, which is inversely related to BMI, TNF-α, and IL-6. These results suggested a possible role for Metrnl in the pathogenesis of IBD, particularly through inflammation modulating.
Development of Boccia Play Support System Based on Fingertip Operation

Field: Computer Science (Physical Sciences)

It is important for the patients with neurological difficulties such as ALS and SMA to improve their quality of life. We focused on the sport called Boccia that can be played even by people with relatively severe disabilities, and the ultimate goal is to construct the system for patients with intractable diseases. In this research, we developed the Boccia play support system which can allow the disabled player to determine both the direction of the lamp and the launch height of the ball, and to launch the ball using movable body part, on the assumption that it can be remotely controlled. Here we paid attention to the slight movement of fingertip. The skin surface on the fingertips was observed with USB camera, and the amount of movement of feature points on the skin surface was derived by using optical flow, and a non-contact interface based on skin strain detection was developed.
Investigating the effect of pelleting on the particle size of commercial poultry feeds: a case study

Field: Agricultural and Biological Sciences (Life Sciences)

SUMMARY: A study was conducted to investigate the effect of pelleting on the particle size of commercial poultry feeds. A total of 38 feed samples each in mash and pellets were collected from commercial poultry feed mills and analyzed for particle size determined as geometric mean diameter (GMD). Mash samples were dry sieved while pellets were wet sieved. The results showed that mash GMD significantly reduced (P < 0.001) from 802.0 to 544.3 µm when the samples were pelleted, whereas the geometric standard deviation (GSD) was increased (P = 0.037) from 2.029 to 2.135 µm. The calculated minimum GMD, maximum GMD, and GMD range of pelleted feeds were significantly reduced (P < 0.001) compared with mash feeds. Pelleting did not affect (P = 0.242) particles larger than 4.0 mm. However, particles in size 0.5 to 4.0 mm were significantly reduced (P < 0.001) in quantity, whereas particles smaller than 0.5 mm were significantly increased (P < 0.001) in pellets. A strong Pearson's correlation (R2 = 0.659) was observed between mash GMD and the reciprocal of pellet GMD. To predict pellet GMD, the validation results of the models produced showed that a linear model can be used to estimate pellet GMD as a function of mash GMD efficaciously with the least change in R2 and predictability error compared with bivariate polynomial fit models with degrees 2 to 4. For wheat-soy-based commercial feeds, the particle size (GMD) is reduced by about 32% when the mash is pelleted and the GMD of pellets can be predicted with reasonable confidence from a measure of mash feed GMD.
Supplementary Figure 1 from HEF1 Is a Crucial Mediator of the Proliferative Effects of Prostaglandin E<sub>2</sub> on Colon Cancer Cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Supplementary Figure 1 from HEF1 Is a Crucial Mediator of the Proliferative Effects of Prostaglandin E<sub>2</sub> on Colon Cancer Cells
Learning From Experience: Improving Early Tracheal Extubation Success After Congenital Cardiac Surgery*

Field: Medicine (Health Sciences)

Objectives: The many advantages of early tracheal extubation following congenital cardiac surgery in young infants and children are now widely recognized. Benefits include avoiding the morbidity associated with prolonged intubation and the consequences of sedation and positive pressure ventilation in the setting of altered cardiopulmonary physiology. Our practice of tracheal extubation of young infants in the operating room following cardiac surgery has evolved and new challenges in the arena of postoperative sedation and pain management have appeared. Design: Review our institutional outcomes associated with early tracheal extubation following congenital cardiac surgery. Patients: Inclusion criteria included all children less than 1 year old who underwent congenital cardiac surgery between October 1, 2010, and October 24, 2013. Measurements and Main Results: A total of 416 patients less than 1 year old were included. Of the 416 patients, 234 underwent tracheal extubation in the operating room (56%) with 25 requiring reintubation (10.7%), either immediately or following admission to the cardiothoracic ICU. Of the 25 patients extubated in the operating room who required reintubation, 22 failed within 24 hours of cardiothoracic ICU admission; 10 failures were directly related to narcotic doses that resulted in respiratory depression. Conclusions: As a result of this review, we have instituted changes in our cardiothoracic ICU postoperative care plans. We have developed a neonatal delirium score, and have adopted the “Kangaroo Care” approach that was first popularized in neonatal ICUs. This provision allows for the early parental holding of infants following admission to the cardiothoracic ICU and allows for appropriately selected parents to sleep in the same beds alongside their postoperative children.
Carcinogenic hazard of "non-carcinogenic" compounds

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Due to the high rates of industrialization, the biosphere is increasingly polluted by both complete carcinogens and compounds that are not able to induce a tumor on their own, but, as it turned out recently, cause changes in the cell corresponding to particular links in the chain of carcinogenesis. Some of these compounds are of great economic interest, and therefore an international agreement allows their unlimited production. At the same time, when combined, these "semi-carcinogens" can either cause malignant transformation or stimulate the action of ubiquitously widespread carcinogens. The saturation of the biosphere with such xenobiotics may be one of the universal factors of the observed increase in cancer incidence. In this regard, the practice of assessing the carcinogenic hazard of chemical compounds based on mechanistic signs should be changed, since it does not take into account the effect of the carcinogenic background of the environment. In vitro experiments should be carried out not only in standard purified media, but also with the addition of the sum of the main components of biospheric pollution in concentrations found, for example, in blood from the umbilical cord of newborns and breast milk. Such additives need to be created and standardized as is customary for Reference materials.
Differentiated dependability of the 3LIHON concept with main focus on internal node architecture

Field: Engineering (Physical Sciences)

Hybrid optical networks are considered as the most promising architectures for future optical networks, in order to achieve both better cost and performance. Dependability is a topic of increasing interest in order to provide the Quality of Service (QoS) expected for future optical networks. Recently, the 3-Level Integrated Hybrid Optical Network (3-LIHON) has been proposed as a new concept for future optical core networks, including different transport technologies to support a wide range of services. Due to the wide range of future telecommunication services foreseen for next generation optical backbone networks, the 3-LIHON architecture must be provided with differentiated dependability, in order to offer the availability demanded by the most critical services, as well as to utilize network resources efficiently. By focusing in a single 3-LIHON node, this thesis employs component redundancy to present a differentiated survivability model suitable for the 3-LIHON architecture. Several protection mechanisms for two of the three types of traffic supported by 3-LIHON are proposed in this research work. These mechanisms are analyzed by means of different dependability models, i.e. reliability block diagrams and Markov models; and a numerical evaluation of its unavailability is presented. In addition, simulation results measuring the impact on performance of some mechanisms are also presented. Then, the protection mechanisms are compared and evaluated, taking into account not only its unavailability and performance, but also other considerations such as cost and complexity. Finally, based on this evaluation, the best suited mechanisms are selected.
Developing Cost Effective Automation for Cotton Seed Delinting

Field: Agricultural and Biological Sciences (Life Sciences)

A low cost automation system for removal of lint from cottonseed is to be designed and developed. The setup consists of stainless steel drum with stirrer in which cottonseeds having lint is mixed with concentrated sulphuric acid. So lint will get burn. This lint free cottonseed treated with lime water to neutralize acidic nature. After water washing this cottonseeds are used for agriculter purpose. Keywords: Automation,cottonseed,lime water, stainless steel,sulphuric acid
First Case of Cellular Cannibalism in Small-Cell Carcinoma of the Bladder Detected in Peripheral Blood

Field: Medicine (Health Sciences)

Hyein Kang, M.D., Do-Hoon Kim , M.D., Ph.D., Wonmok Lee, M.D., Ph.D., Jungsook Ha, M.D., Ph.D., Namhee Ryoo, M.D., Ph.D., Dong-Seok Jeon, M.D., Ph.D., and Hye Ra Jung, M.D., Ph.D.. Ann Lab Med 2019;39:400-2. https://doi.org/10.3343/alm.2019.39.4.400
Faculty Opinions recommendation of Evolved orthogonal ribosome purification for in vitro characterization.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

We developed orthogonal ribosome-mRNA pairs in which the orthogonal ribosome (O-ribosome) specifically translates the orthogonal mRNA and the orthogonal mRNA is not a substrate for cellular ribosomes. O-ribosomes have been used to create new cellular circuits to control gene expression in new ways, they have been used to provide new information about the ribosome, and they form a crucial part of foundational technologies for genetic code expansion and encoded and evolvable polymer synthesis in cells. The production of O-ribosomes in the cell makes it challenging to study the properties of O-ribosomes in vitro, because no method exists to purify functional O-ribosomes from cellular ribosomes and other cellular components. Here we present a method for the affinity purification of O-ribosomes, via tagging of the orthogonal 16S ribosomal RNA. We demonstrate that the purified O-ribosomes are pure by primer extension assays, and structurally homogenous by gel electrophoresis and sucrose gradients. We demonstrate the utility of this purification method by providing a preliminary in vitro characterization of Ribo-X, an O-ribosome previously evolved for enhanced unnatural amino acid incorporation in response to amber codons. Our data suggest that the basis of Ribo-X's in vivo activity is a decreased affinity for RF1. PMID: 20185573 Funding information This work was supported by: Medical Research Council, United Kingdom Medical Research Council, United Kingdom Grant ID: MRC_MC_UP_A024_1008 Medical Research Council, United Kingdom Grant ID: MRC_MC_U105181009
The Measures taken to check the Diphtheria Outbreak of 1901 at Colchester

Field: Medicine (Health Sciences)

Finally I wish to draw particular attention to the following facts:— 1. The striking diminution in the case-mortality at the Mile End Hospital which followed the systematic use of antitoxin. 2. The subsidence of the epidemic during the season when diphtheria is commonly most prevalent. 3. The opening of the schools in September without any increase in the prevalence of the disease. 4. The persistence of diphtheria bacilli for long periods in certain of the convalescents and contacts. 5. The success of preventive measures based upon the belief that diphtheria is spread mainly by personal contact, and through the inter-mediation of healthy persons and other who by the means usually employed are not recognised to be suffering from the disease.
The Expanding Role of LEAs in Special Education Teacher Preparation: The View from a Local School District

Field: Social Sciences (Social Sciences)

Increasingly local school districts are implementing alternative certification (AC) programs to alleviate the shortage of special education teachers. We situate special education AC programs in the context of an earlier AC movement in regular education, discuss important differences between the two, and attempt to clarify the terminology. Following a review of published reports of AC programs based in universities, state education agencies, and local school districts, we report the Volusia County Alternative Add-On Certification Program (VCAAP), emphasizing the importance of IHE collaboration in the development and progress of the program. We conclude with a discussion of necessity and collaboration, the paper's dominant themes, and suggest how the interplay of these themes can influence the future course of teacher education in special education.
Frontal Lobotomy and Affective Behavior: A Neurophysiological Analysis

Field: Neuroscience (Life Sciences)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Archives of Neurology & Psychiatry HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the Archives of Neurology & Psychiatry journal
Compound Semiconductor Nanowires for Optoelectronic Device Applications

Field: Materials Science (Physical Sciences)

The excitement of nanowire research is due to the unique electronic and optical properties of these nanostructures. Both axial and radial heterostructure nanowires have been proposed as nano-building blocks for the next generation devices, which are expected to revolutionise our technological world. The unique properties stem from their large surface area-to-volume ratio, very high aspect ratio, and carrier and photon confinement in two dimensions. These nanowires are usually grown by the so-called vapor-liquid-solid mechanism, which relies on a metal nanoparticle to catalyze and seed the growth. An alternative technique to grow the nanowires is by selective area growth technique, where a dielectric mask is first patterned on the substrate prior to growth. In this talk, I will present an overview of compound semiconductor nanowire research activities at The Australian National University. The optical and structural properties of binary and ternary III-V nanowires including GaAs, InGaAs, InP and GaAsSb nanowires grown by metal-organic vapour phase epitaxy will be presented. Various issues such as tapering of the nanowires, compositional non-uniformity along nanowires, crystal structure, carrier lifetime and polarization effect will be discussed. I will also present our results of III-V nanowires grown on Si substrate which are of great interests for the integration of nano-optoelectronic devices on Si platforms. Our results of enhancing the quantum efficiency of nanowires by using plasmonics are promising to improve the performance of nanowire devices. Finally, the results from our nanowire lasers and solar cells will be presented.
Analysis of Air Flow and Turbulent Fluxes Features of Night Fog

Field: Environmental Science (Physical Sciences)

The air flow and turbulent fluxes features during the radiation fog formed on the dawn of 17 October 2007 is discussed in order to study the mechanism of an unexpected night fog, based on the meteorological and turbulent data obtained from the 250 m height tower in Tianjin, as well as the NCEP reanalysis data and other observational data. The results show that the lower layer easterly flow coming from the south region of the Northeast cold high pressure led to remarkable temperature fall and humidity value increase in the daytime prior to the fog formation, which quickly turned the dry boundary layer to be moist. The vapor transfer indicated that the vapor of the radiation fog was provided by the easterly advection from Bohai Sea, not from local area. Turbulent vapor fluxes increased ten times as that before the fog. The horizontal vapor fluxes transported against the wind direction, which led to the escape of water vapor from Tianjin city and the dissipation of fog.
Rethinking Subcultural Resistance

Field: Social Sciences (Social Sciences)

This article reconceptualizes subcultural resistance based on an ethnographic examination of the straight edge movement. Using the core values of straight edge, the author’s analysis builds on new subcultural theories and suggests a framework for how members construct and understand their subjective experiences of being a part of a subculture. He suggests that adherents hold both individual and collective meanings of resistance and express their resistance via personal and political methods. Furthermore, they consciously enact resistance at the micro, meso, and macro levels, not solely against an ambiguous “adult” culture. Resistance can no longer be conceptualized in neo-Marxist terms of changing the political or economic structure, as a rejection only of mainstream culture, or as symbolic stylistic expression. Resistance is contextual and many layered rather than static and uniform.