jimnoneill/paper-to-field-training huggingface dataset:
Child's play: designing play spaces that support healthy cognitive development in children

Field: Social Sciences (Social Sciences)

Play spaces are places where children go to explore, play, exercise and interact with other children. Play spaces should be designed to support emerging behaviors and developing skills in children from their years of infancy to adolescence. The progression of children?s intellectual, physical, social, and emotional development from infancy to adolescence can be matched with suggested environmental designs to create holistic landscapes for their healthy cognitive development. By matching environmental designs to developmental stages, we can create comfortable play spaces that allow children to feel ease and joy in the play space. ? The study focuses on three stages of children?s development from the Sensorimotor stage to Concrete Operational stage, as defined by Jean Piaget. Sensorimotor stage occurs from birth to two years of age. Design should address the factors that child has limited mobility and experiences the world through their senses. Pre?operational stage occurs from age two to seven. Perceptual processes dominate the child?s thinking therefore play spaces should support their behaviors of symbolic thoughts and pretend play. Concrete operational stage occurs from age seven to eleven. There is a shift into logical thinking, so spaces should accommodate children?s social and rule play games. ? The three case studies presented highlight how design elements have been applied in play spaces for learning, to engage the senses, and for therapeutic benefit. This study found that in play spaces, the most significant environmental design elements related to childhood development are: structures that provide opportunity for climbing, swinging and sliding, as well as vegetation and loose parts, and water. These variables provide physical benefits, social and emotional development, and sensory stimulation, the most important attributes that make successful spaces for Child?s Play.
The (Emotive) worm at the core: The role of emotional problems in the process from physical suffering to psychological distress—A multiple step mediation analysis.

Field: Psychology (Social Sciences)

10063 Background: Anxiety, depression and fear are all among oppressive emotions that oncological patients have to face almost every day. On one hand, these emotional problems seem to be triggered by physical, relational and practical problems; and on the other hand, these emotive troubles seem to lead to psychological distress – one of the most important indexes of mental health suffering in oncological patients (NCCN, 2002). The aim of the study was to test a multiple step mediation model (Hayes, 2013) in which emotional problems have a central role in the process leading to psychological distress. Methods: An observational research design was used. Patients (N = 211, mean age: 64.84, SD = 11.35) were consecutively enrolled at the Department of Medical Oncology at Presidio Ospedaliero of Saronno, ASST Valle Olona, Italy. Patients were tested with Distress Thermometer and Problem List (DT&PL; NCCN, 2003), assessing: (A) distress; (B) practical problems (α = .62); (C) social relations (α = .64); (D) emotional (α = .82) and (E) physical problems (α = .72). Results: First, a CFA was performed in order to test the structure of the proposed Problem List. The original five factor solution was supported by adequate fit indices: RMSEA = .055 (.048–.062), p(RMSEA < .05) = .118. Afterward, multiple step mediation analysis (5000 bootstrap resampling) showed model’s statistical significance [F = 57.52, p < .001; R2 = .54; η2 = .288]. The relationship between physical problems and distress was fully mediated (path c’: β = .089; p = .306; 95%CI: -.083, .262), first by practical problems (path a1: β = .057, p < .001; 95%CI: .031, .084), hence by relationships problems (path d1: β = .207, p < .001; 95%CI: .097, .316), and finally by emotional problems (path d2: β = .962, p < .001; 95%CI: .544, 1.37; and path b3: β = .808, p < .001; 95%CI: .612, 1.01). Conclusions: These results highlight the role of emotions, practical and relational problems in the process that lead to distress. These findings point out a new way in which psycho-oncologists should structure psychological interventions, in order to both reduce psychological suffering and improve a better quality of life in oncological settings.
Conflictos antiseñoriales en el reino de Castilla a fines de la Edad Media:viejas preguntas, ¿Nuevas respuestas?

Field: Arts and Humanities (Social Sciences)

The purpose of this article is to review the historiography of anti-seigneurial conflict during the Late Middle Ages in Castile. The study of social conflict and especially antiseigneurial conflict was one of the main interests of study of the late Professor Julio Valdeón. Thirty-five years have passed since the publication of one of his major works in this field, Social Conflict in the Kingdom of Castile during the 14th and 15th Centuries. In tribute to Professor Valdeón, this article looks again at his work on anti-seigneurial conflict, studies the evolution in the historiography, and poses a series of questions to further the analysis of this problem.
Treatment adherence: what is the best that can be achieved?

Field: Medicine (Health Sciences)

The modest effectiveness of disease modifying therapies (DMTs) in MS has been amply illustrated by a series of pivotal trials, albeit short term in the context of a life-long disease. Most neurologists and people with MS welcome the opportunity to affect the course of this disorder. However, the individual with MS might not be fully aware of the importance of continuing treatment with these drugs in the absence of feeling better (and often feeling worse) while taking therapy.
Clinical case of renal manifestations in the onset of diffuse large B-cell lymphoma in a teenager

Field: Medicine (Health Sciences)

This article presents a clinical case of diffuse large B-cell lymphoma in a teenager, who had laboratory and clinical signs of acute kidney injury in the onset of the disease. The presented case is characterized by the late manifestation of the disease in the absence of classical tumor markers. The diagnosis was verified only following a repeat spine MRI. This case may be relevant for pediatricians, pediatric oncologists and hematologists, pediatric nephrologists.
COMPENSATION FOR INDIVIDUAL PREJUDICE IN EUROPEAN LITIGATION OF HUMAN RIGHTS

Field: Social Sciences (Social Sciences)

This paper aims at presenting some problems regarding individual prejudice, by invoking the European Convention on Human Rights. Starting from the fact that the Convention lies in the approach of positive law in the sense of creating a legal regime of rights and freedoms by establishing a system of protection through legal proceedings , of the individual, acting as a guarantor, jurisprudence exercise transferred the interest for repairing damages caused by the violation of rights that require satisfaction of some compensation measures in the form of damages. So, repairing methods are achieved by equitable satisfaction.
Human–Wildlife Interactions: Turning Conflict into Coexistence edited by Beatrice Frank, Jenny A. Glikman & Silvio Marchini (2019) 476 pp., Cambridge University Press, Cambridge, UK. ISBN 978-1-108402583 (pbk), GBP 34.99.

Field: Environmental Science (Physical Sciences)

Human–Wildlife Interactions: Turning Conflict into Coexistence edited by Beatrice Frank, Jenny A. Glikman & Silvio Marchini (2019) 476 pp., Cambridge University Press, Cambridge, UK. ISBN 978-1-108402583 (pbk), GBP 34.99. - Volume 54 Issue 5
Psychiatry Goes to School: Child Guidance and the Prevention of Juvenile Delinquency, 1940–42

Field: Social Sciences (Social Sciences)

In his 1965 memoir Manchild in the Promised Land, the former Harlem gang member Claude Brown recounted the day he appeared in Domestic Relations Court. In 1948 Brown had been caught robbing a store on 147th Street. The presiding justice that January day was Polier's colleague Jane Bolin. Not quite eleven years old, young Claude had heard of her. Regularly featured in the black press, Judge Bolin was a well-known African American role model. A force for antiracism in the 1940s, she was a member of the NAACP's Board of Directors and a tireless advocate for women, children, and Harlem.
Upregulated Long Non-Coding RNA LL22NC03-N64E9.1 Promotes the Proliferation and Migration of Human Breast Cancer Cells by Silencing Kruppel-Like Factor 2 Expression

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Weibin Lian,1,* Xiaohua Jiang,2,* Liangqiang Li,1,* Qinglan Wang,1 Chengye Hong,1 Peidong Yang,1 Debo Chen1 1Department of Breast Surgery, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian, People&amp;rsquo;s Republic of China; 2Department of Orthopedics, Xiang&amp;rsquo;an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, People&amp;rsquo;s Republic of China*These authors contributed equally to this workCorrespondence: Weibin Lian; Debo Chen Tel +86-15260819892; +86-13600738668Email weibinlian@fjmu.edu.cn; deboqz@163.comIntroduction: Recently, the significant regulatory effects of lncRNAs on the oncogenesis and growth of tumor have been demonstrated by an increasing number of research projects. A previous study showed that LL22NC03-N64E9.1 could promote the development of colorectal cancer, especially via enhanced cell proliferation. Similarly, this lncRNA should have comparable functions in breast cancer (BC), which requires in-depth investigation. Therefore, this study was designed to explore the correlation of LL22NC03-N64E9.1 with BC.Methods: qRT-PCR was used to assess the relative expression of LL22NC03-N64E9.1 in BC tissues. Cell viability examination and colony formation experiments were performed to investigate the role of LL22NC03-N64E9.1 in BC cell&amp;rsquo;s proliferation. Transwell assays were used to explore the effects of LL22NC03-N64E9.1 on BC cell&amp;rsquo;s migration. RNA immunoprecipitation, chromosome immunoprecipitation assay and rescue experiments were performed to analyze the association of LL22NC03-N64E9.1 with target proteins and genes in BC cells.Results: We identified that LL22NC03-N64E9.1 is an oncogene, upregulated in BC, which was verified in a cohort of 48 pairs of BC tissues. Based on the loss-of-function experiments, silencing LL22NC03-N64E9.1 expression significantly inhibited malignancy progression. In terms of the mechanism, LL22NC03-N64E9.1 acted on the enhancer of zeste homolog 2 (EZH2) by direct binding, which promoted BC cell growth. Furthermore, in the promoters of KLF2, the trimethylation of H3K27 could be regulated by LL22NC03-N64E9.1 as the mediator.Conclusion: Relying on the LL22NC03-N64E9.1/EZH2/KLF2 pathway, the lncRNA LL22NC03-N64E9.1 was significantly associated with BC development and could, therefore, be a potential therapeutic target to block BC growth.Keywords: breast cancer, lncRNA, LL22NC03-N64E9.1, H3K27me3, KLF2
The prevalence and antimicrobial resistance of Haemophilus influenzae in prepubertal girls with vulvovaginitis

Field: Medicine (Health Sciences)

Abstract Background: To determine the prevalence of Haemophilus influenzae vulvovaginitis in prepubertal girls and the antimicrobial resistance of H.influenzae strains isolated from vulval specimens. Methods: Isolates of H.influenzae from vulval swabs of prepubertal girls with vulvovaginitis received at The Children's Hospital, Zhejiang University School of Medicine during 2016-2019 were studied. Vulval specimens were inoculated on Haemophilus selective chocolate agar. Antimicrobial susceptibility tests were performed using the disk diffusion method. A cefinase disk was used to detect β -lactamase. Results : A total of 4142 vulval specimens were received during the 4 years, 649 isolates of H. influenzae were isolated from 642 girls aged 6 months to 13 years, with a median of 5y. There were peaks of isolates from April to July seen in the vulval isolates. In total, the ampicillin resistance rate was 39.1% (250/640); 33.2% strains (211/636) were for β -lactamase-positive isolates, 6.6% strains (42/635) were β -lactamase-negative and ampicillin-resistant (BLNAR) isolates. The resistance rates of H. influenzae isolates to amoxycillin-clavulanic acid, ampicillin-sulbactam, cefuroxime, ceftriaxone, cefotaxime, meropenem, levofloxacin, sulfamethoxazole-trimethoprim, azithromycin, and chloramphenicol were 26.4%, 21.8%, 24.8%, 1.7%, 1.0%, 0.2%, 0%, 47.7%, 10.2%, and 1.1%, respectively. MDR was present in 41 (6.4%) of the 642 H. influenzae isolates, with the most prevalent MDR phenotype of ampicillin-sulfamethoxazole-trimethoprim-azithromycin resistance. Conclusions : H. influenzae is a common cause of vulvovaginitis in prepubertal girls. Laboratories should ensure that they include media appropriate for the isolation of H. influenzae . It’s worth noting of ampicillin resistance of H. influenzae in clinical management.
Photocatalytic Activity of Synthetic N‐doped TiO2/Reduced Graphene Oxide Crystalline Composites

Field: Chemistry (Physical Sciences)

Abstract N‐doped TiO 2 /reduced graphene oxide (N‐TiO 2 /RGO) composites were prepared by a hydrothermal method. Characterization and photocatalytic tests showed that the N‐TiO 2 /RGO composites were more efficient for degrading effluents in comparison with the pure TiO 2 powders and the N‐doped TiO 2 powders. The photocatalytic performance of the composites was enhanced with the increase of the reduced graphene oxides' content, whose degradation rate constant was higher than that of N‐TiO 2 under simulated sunlight irradiation. After five successive cycles, 50 % N‐TiO 2 /RGO still exhibited high activity, which indicates that the composites are stable under irradiation. An innovative strategy for the exploration of advanced photocatalysts in wastewater treatment is provided.
Mutagenesis of a Specificity-Determining Residue in Tyrosine Hydroxylase Establishes That the Enzyme Is a Robust Phenylalanine Hydroxylase but a Fragile Tyrosine Hydroxylase

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The aromatic amino acid hydroxylases tyrosine hydroxylase (TyrH) and phenylalanine hydroxylase (PheH) have essentially identical active sites; however, PheH is nearly incapable of hydroxylating tyrosine, while TyrH can readily hydroxylate both tyrosine and phenylalanine. Previous studies have indicated that Asp425 of TyrH is important in determining the substrate specificity of that enzyme [Daubner, S. C., Melendez, J., and Fitzpatrick, P. F. (2000) Biochemistry 39, 9652-9661]. Alanine-scanning mutagenesis of amino acids 423-427, a mobile loop containing Asp425, shows that only mutagenesis of Asp425 alters the activity of the enzyme significantly. Saturation mutagenesis of Asp425 results in large (up to 10(4)) decreases in the V(max) and V(max)/K(tyr) values for tyrosine hydroxylation, but only small decreases or even increases in the V(max) and V(max)/K(phe) values for phenylalanine hydroxylation. The decrease in the tyrosine hydroxylation activity of the mutant proteins is due to an uncoupling of tetrahydropterin oxidation from amino acid hydroxylation with tyrosine as the amino acid substrate. In contrast, with the exception of the D425W mutant, the extent of coupling of tetrahydropterin oxidation and amino acid hydroxylation is unaffected or increases with phenylalanine as the amino acid substrate. The decrease in the V(max) value with tyrosine as the substrate shows a negative correlation with the hydrophobicity of the amino acid residue at position 425. The results are consistent with a critical role of Asp425 being to prevent a hydrophobic interaction that results in a restricted active site in which hydroxylation of tyrosine does not occur.
Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Lipocalin 2 (Lcn2) is a multifunctional innate immune protein that limits microbial overgrowth. Our previous study demonstrated that the gut microbiota directly induces intestinal Lcn2 production, and Lcn2-deficient ( Lcn2 −/− ) mice exhibit gut dysbiosis. Coincidentally, gut dysbiosis is associated with metabolic syndrome pathogenesis, and elevated Lcn2 levels has been considered a potential clinical biomarker of metabolic syndrome. Yet whether Lcn2 mitigates or exacerbates metabolic syndrome remains inconclusive. Our objective was to determine whether Lcn2 deficiency-induced compositional changes in gut microbiota contribute to gain in adiposity in aged mice. Utilizing Lcn2 −/− mice and their wild-type (WT) littermates, we measured metabolic markers, including fasting blood glucose, serum lipids, fat pad weight, and insulin resistance at ages 3, 6, and 9 mo old. Relative to WT mice, aged Lcn2 −/− mice exhibited a gain in adiposity associated with numerous features of metabolic syndrome, including insulin resistance and dyslipidemia. Surprisingly, supplementation with a high-fat diet did not further aggravate metabolic syndrome that spontaneously occurs in Lcn2 −/− mice by 6 mo of age. Interestingly, chow-fed Lcn2 −/− mice displayed marked differences in the bacterial abundance and metabolomic profile of the gut microbiota compared with WT mice. Overall, our results demonstrate that Lcn2 is essential to maintain metabolic and gut microbiotal homeostasis, where deficiency induces spontaneous delayed onset of metabolic syndrome.
Supplementary Figure 3 from Suppression of Integrin α3β1 in Breast Cancer Cells Reduces <i>Cyclooxygenase-2</i> Gene Expression and Inhibits Tumorigenesis, Invasion, and Cross-Talk to Endothelial Cells

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Supplementary Figure 3 from Suppression of Integrin α3β1 in Breast Cancer Cells Reduces <i>Cyclooxygenase-2</i> Gene Expression and Inhibits Tumorigenesis, Invasion, and Cross-Talk to Endothelial Cells
Retigabine: fewer drug interactions.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

There are already about a dozen antiepileptic drugs with acceptable harm-benefit balances that can be used in combination therapy for adult patients whose partial epilepsy is not adequately controlled by successive single-agent regimens. Retigabine (Trobalt, GlaxoSmithKline) has now been authorised in the European Union in this indication. Clinical evaluation is based on 3 double-blind randomised controlled trials in which either retigabine or placebo was added to an ineffective ongoing treatment. An additional 30% of patients treated with retigabine (in absolute numbers) had at least a 50% reduction in the monthly frequency of seizures. This translates to approximately 50% of patients with a reduced seizure rate as compared with about 20% of patients on placebo. Based on indirect comparisons, which must be interpreted with care, this efficacy seems similar to that of other antiepileptic drugs. Retigabine shares several adverse effects with other antiepileptic drugs, especially neuropsychiatric disorders. Retigabine can also cause urinary disorders (5%), psychotic disorders (about 6%) and urolithiasis. It also appears to prolong the QT interval. Retigabine does not interfere with major cytochrome P450 isoenzymes or with P-glycoprotein-mediated drug transport. About 30% of the ingested dose is excreted unchanged in urine. The risk of pharmacokinetic interactions is low in patients with normal renal function. In practice, retigabine is another option for second-line combination therapy in patients at high risk of drug interactions.
Smart Warehousing as a Wave of the Future

Field: Business, Management and Accounting (Social Sciences)

Background: The unprecedented supply chain disruptions caused by the prolonged COVID-19 pandemic forced many firms to change their way of doing business dramatically. These changes include quickly responding to the growing demand for online orders and the corresponding direct shipments to customer locations. These changes have been further accelerated by rapid technological innovations resulting from the fourth industrial revolution (Industry 4.0). One of the most notable technological transformations that we have witnessed is the growing popularity of smart warehousing concepts. Although smart warehousing may represent a wave of the warehousing future, the published literature rarely documents its underlying principles, specific application targets, and potential impacts on supply chain performance. This research aims to identify key drivers of the digital warehousing revolution and describe important value propositions for warehousing automation. Methods: To help companies develop smart warehouses successfully as an integral part of a supply chain link, I conceptualize an ideal smart warehousing system, design its basic architecture, propose specific milestones for monitoring the progress of smart warehouse development, and then, identify critical success factors for its full utilization in today’s volatile warehousing environment. This paper employed qualitative content analysis to conceptualize smart warehousing development and establish a smart warehousing framework. Results: A smart warehouse will bring many managerial benefits, including warehousing cost efficiency, labor productivity, and agility in the era of the knowledge economy. Conclusions: This paper will enable companies to accelerate digital transformation and improve their competitiveness amid the post-pandemic industrial revolution.
Involving the quiet majority

Field: Social Sciences (Social Sciences)

Student affairs researchers have spent considerable energy studying the affect students' active participation in co-curricular activities has on student success, retention, and completion. Students becoming actively involved in co-curricular activities can have a positive effect on their overall success. However, much of the research pertaining to student engagement has primarily focused on residential student experiences and has often overlooked actively involved commuter students. This thesis contributes to the existing research by specifically investigating commuter student behavior. The study examines the success of commuter students aged 18 to 22 who are engaged in co-curricular experiences at a private, mid-sized, four-year university in New Jersey. The primary question guiding the research is: What are the experiences of commuter students aged 18 to 22 who are engaged in co-curricular activities at a private four year university in New Jersey? The study's line of questioning and theoretical framework is based on Astin's (1984) seminal I-E-O (Input-Environment-Output) model focusing on student involvement.
Stop the Madness! An Examination of Mental Health Stigma and Proposal to Implement Widespread Efforts for its Reduction

Field: Social Sciences (Social Sciences)

Many people in the United States are affected by mental health conditions. Mental health stigma is a social problem characterized by negative representation in the media, numerous barriers to obtaining treatment, and feelings of shame for those affected by a mental health disorder. While there is evidence of positive outcomes to some anti-stigma campaigns, there has been a failure for these programs to become widespread, covering all parts of American society. This paper has been created to present recommendations for widespread initiatives at the federal and state level. Recommendations for training and sensitivity programs targeting places of employment and schools, along with alteration of perceptions of people with mental illness in the media have been made. This topic and resulting recommendations may pave the path to reduce the severity and madness of mental health stigma in society.