1720 PSAV CHANGE ACCORDING TO AN AGE GROUP AND ASSOCIATION BETWEEN PSAV AND INITIAL SERUM PSA LEVEL IN HEALTHY MEN

Field: Medicine (Health Sciences)

You have accessJournal of UrologyProstate Cancer: Detection and Screening I1 Apr 20101720 PSAV CHANGE ACCORDING TO AN AGE GROUP AND ASSOCIATION BETWEEN PSAV AND INITIAL SERUM PSA LEVEL IN HEALTHY MEN June Hyun Han, Yong Taec Lee, Sang Wook Park, Nak Young Choi, Kyoung Won Kwak, Seung Hyun Ahn, In Ho Chang, and Soon Chul Myung June Hyun HanJune Hyun Han More articles by this author , Yong Taec LeeYong Taec Lee More articles by this author , Sang Wook ParkSang Wook Park More articles by this author , Nak Young ChoiNak Young Choi More articles by this author , Kyoung Won KwakKyoung Won Kwak More articles by this author , Seung Hyun AhnSeung Hyun Ahn More articles by this author , In Ho ChangIn Ho Chang More articles by this author , and Soon Chul MyungSoon Chul Myung More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1568AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We investigated PSAV change according to an age group and association between PSAV and initial serum PSA level in healthy men with initial serum PSA levels of 4.0 ng/ml or less. METHODS Between January 2003 and December 2008, 88,677 healthy male employees of the Korea Hydro and Nuclear Power Co., LTD and Korea Electric Power Corporation with medical checkups including serum PSA were enrolled. Among those, we enrolled 17,619 men who had two or more PSA measurements with an interval of at least 12 months and had an initial PSA level of 4.0 ng/ml or less and did not had a prior diagnosis of prostate cancer or evidence of urinary tract infection. PSAV was defined as the converted values per year after the difference between the initial and the last PSA values was divided by the interval between the measurements. RESULTS PSAV had the normal distribution and mean (±SD) of PSAV was 0.009±0.220 ng/ml/yr. Mean age (±SD) of cohort was 42.80±8.64 yrs. Mean (±SD) of initial serum PSA level was 0.87±0.53 ng/ml and mean (±SD) of interval of measurements was 3.55±1.34 yrs. PSAV increased with increasing age groups (Pearson correlation test, r=0.053, P<0.001) and decreases with higher initial serum PSA level (Pearson correlation test, r=-0.219, P<0.001). Age, initial serum PSA level and interval between measurements were significant contributors to PSAV in multiple linear regression analysis (P<0.001). CONCLUSIONS These results reveal the trends that PSAV increases with increasing age and decreases with higher initial serum PSA level. Adjustment of PSAV according age is thought to be needed for the accuracy of the test and a better understanding of the determinants of PSAV is needed to distinguish factors altering the risk of prostate cancer. Seoul, Republic of Korea© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e664 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information June Hyun Han More articles by this author Yong Taec Lee More articles by this author Sang Wook Park More articles by this author Nak Young Choi More articles by this author Kyoung Won Kwak More articles by this author Seung Hyun Ahn More articles by this author In Ho Chang More articles by this author Soon Chul Myung More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...