jimnoneill/paper-to-field-training huggingface dataset:
Progress Towards a Rechargeable Multivalent Battery

Field: Materials Science (Physical Sciences)

Cheaper batteries with higher capacity would increase the market penetration of electric vehicles and grid storage systems. One way to achieve these gains in battery performance is to utilize a metal anode such as lithium, magnesium or calcium. Lithium metal anodes have been extensively studied for decades, but still have not been commercialized. On the other hand, comparatively little research has been performed on magnesium or calcium systems. Magnesium metal has been shown to be less susceptible to the formation of dendrites than lithium. No one is yet able to plate and strip calcium, however, it does possess a lower voltage than magnesium and a non-passivating oxide. In order to rapidly explore the potential of these battery systems, we have developed techniques to study cathode materials without the need for a working metal anode. In doing this we have determined that corrosion issues are more severe in these electrolytes than their lithium counterparts. Furthermore, we have determined a class of materials that can intercalate Mg and Ca in nonaqueous electrolytes. These materials are characterized by a combination of techniques including energy dispersive X-ray spectroscopy (EDX), X-ray absorption near-edge spectroscopy (XANES) and X-ray diffraction (XRD) to prove intercalation of the multivalent ion. Additionally, we have made the first attempts to pair these materials with low voltage anode materials. These anode materials include using Mg metal and metallic anodes that react with the multivalent ion.
Is Libertarian Paternalism an Oxymoron?

Field: Economics, Econometrics and Finance (Social Sciences)

In this article I have attempted to discuss two points brought up by Sunstein and Thaler's new perspective on paternalism. The first is that whatever individuals do, they have to take second rank decisions, i.e. decisions that are equally attractive for them but impact others' people welfare. They then face a three alternative choice: either they do not care of the collateral consequences of their choice and act randomly, either they select the option that will make others better off, either they pick the option that will make others worst off. The authors assume they will necessarily act benevolently. I argued this statement is mistaken, and that the authors did not sufficiently distinguish the functional and the personal motivations of the planners. This leads me to define paternalism as the personal benevolence of the planners. Because they do not have any professional or moral duty towards the non-planners, they have absolutely no obligation to be benevolent. In most cases, the easiest choice is to act randomly. This incertitude about the planners' choice has dramatic consequences on non-planners: unless they know and trust the planners they cannot expect them to be paternalistic. They are subsequently less prone to blindly adopt default rules. The second point of the authors is that one can conceive a paternalistic system based on planners' benevolence that would not infringe libertarian principles. Default rules can, for instance, be combined with absolute freedom of choice. I argued that freedom of choice would not contribute to individual freedom if choices are not voluntary. The easiest they set up opting out options the less discriminating their system is, and eventually the most inefficient it will be.
VARIATIONS IN THE ANTISCORBUTIC POTENCY OF MILK

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Epigenetic Pathways to Ribosomal DNA Silencing

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

SUMMARY Heterochromatin is the transcriptionally repressed portion of eukaryotic chromatin that maintains a condensed appearance throughout the cell cycle. At sites of ribosomal DNA (rDNA) heterochromatin, epigenetic states contribute to gene silencing and genome stability, which are required for proper chromosome segregation and a normal life span. Here, we focus on recent advances in the epigenetic regulation of rDNA silencing in Saccharomyces cerevisiae and in mammals, including regulation by several histone modifications and several protein components associated with the inner nuclear membrane within the nucleolus. Finally, we discuss the perturbations of rDNA epigenetic pathways in regulating cellular aging and in causing various types of diseases.
Periodontal Health, Salivary Status, and Metabolic Control in Children with Type 1 Diabetes Mellitus

Field: Dentistry (Health Sciences)

Background: The aim of this study was to determine whether detectable periodontal destruction and alterations in the salivary status were present with duration of diabetes in children with type 1 insulin‐dependent diabetes mellitus (type 1 DM) as compared to healthy controls. Methods: Sixteen newly diagnosed children with DM (group 1), 16 children with type 1 DM of long duration (group 2), and 16 healthy children (group 3) participated in the study. Periodontal health was assessed by plaque index, gingival index, bleeding on probing, and periodontal probing depths. The flow rate, pH, buffering capacity, and peroxidase activities of stimulated saliva were determined. The data were analyzed by Kruskall‐Wallis, Student t test, and Pearson's correlation analysis. Results: The mean values for fasting blood glucose levels for the diabetic groups were significantly higher than for the controls. The mean values for salivary buffering capacities and salivary pH from the diabetic groups were significantly lower than for the controls. The plaque index values for the diabetic groups were significantly higher than for the controls. The mean gingival index value for group 1 was significantly lower than for group 2. The mean periodontal probing depths for group 1 were similar to those of the non‐DM controls, but the mean periodontal probing depths for group 2 were significantly greater than for both the non‐DM controls and group 1. Group 1 had significantly greater bleeding on probing scores than did the other groups ( P <0.05). Conclusion: The glycemic status of the diabetic subjects affects the periodontal probing depths, salivary pH, buffering capacity, and peroxidase activity. J Periodontol 2003;74:1789‐1795 .
Attitudes of beef producers to disbudding and perception of pain in cattle

Field: Veterinary (Health Sciences)

Abstract Pain is an indicator of welfare status in livestock, and attitudes play a key role in the assessment and treatment of pain in animals. Veterinarians’ and dairy producers’ perceptions of cattle pain are affected by gender, age and work experience. The aim of this paper was to study beef producers’ attitudes regarding disbudding as well as the painfulness of certain cattle diseases. A questionnaire was sent out to 1,000 Finnish beef producers and the response rate was 44%, representing 19% of all Finnish beef producers. Producers graded their attitudes on a five-point Likert scale and perception about pain on an eleven-point numerical scale. Factor analysis was used and four factors were established. These factors described producers’ assessment of disbudding-related pain, their sensitivity to pain in cattle, their willingness to self-medicate disbudded calves and their perceived importance of horns. Factor scores were tested for differences between genders and the use of disbudding on farms with Mann Whitney U-tests . Kruskal-Wallis tests were used to assess differences among producers’ age, work experience and herd size. Female beef producers assessed animal pain higher than male beef producers. Older and more experienced beef producers showed more positive attitudes towards cattle with horns than younger or less-experienced ones. Older beef producers were more sensitive to cattle pain than younger producers and beef producers with a smaller herd size took disbudding pain more seriously and were more sensitive to cattle pain than the producers with larger herds. Producers who did not use disbudding valued horns more than producers using disbudding.
On learning-based methods for design-space exploration with high-level synthesis

Field: Computer Science (Physical Sciences)

This paper makes several contributions to address the challenge of supervising HLS tools for design space exploration (DSE). We present a study on the application of learning-based methods for the DSE problem, and propose a learning model for HLS that is superior to the best models described in the literature. In order to speedup the convergence of the DSE process, we leverage transductive experimental design, a technique that we introduce for the first time to the CAD community. Finally, we consider a practical variant of the DSE problem, and present a solution based on randomized selection with strong theory guarantee.
[Role of sodium-calcium exchanger in the myocardial protection against ischemia-reperfusion injury].

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Present study was aimed at investigation into the role of sodium-calcium exchanger (NCX) in myocardial ischemia-reperfusion injury and ischemic preconditioning (IPC). Experiments were performed in vivo rat model of regional myocardial ischemia-reperfusion. It was shown that inhibition of reverse mode of NCX with selective blocker KB-R7943 at a dose of 10 mg/kg resulted in significant decrease in occurrence and severity of ischemic ventricular tachyarrhythmias. Furthermore, administration of KB-R7943 caused potentiation of the antiarrhythmic effect exerted by single episode of IPC. However, KB-R7943 exerted no effect on myocardial infarction size nor affected infarction size limitation by IPC. In conclusion, inhibition of reverse mode of NCX conferred significant antiarrhythmic effect against ischemic rhythm disorders but it was ineffective in terms of infarction size limitation.
Tailoring nonuniform local orbital angular momentum density

Field: Physics and Astronomy (Physical Sciences)

As is well known, a light beam with a helical phase carries an optical orbital angular momentum (OAM), which can cause the orbital motion of trapped microparticles around the beam axis. Usually, the speed of the orbital motion is uniform along the azimuthal direction and depends on the amount of OAM and the light intensity. Here, we present the reverse customized method to tailor the nonuniform local OAM density along the azimuthal direction of the focal field, which has a hybrid polarization distribution and maintains a doughnut-shaped intensity profile. Theoretical analysis and experimental results about the orbital motion of the trapped polystyrene sphere show that the nonuniform local OAM density can be tailored by manipulating the polarization states of the focal field. Our results provide an ingenious way to control the local tangential optical force and the speed of the orbital motion of particles driven by the local OAM density and will promote exciting possibilities for exploring ways to control the mechanical dynamics of microparticles in optical trapping and microfluidics.
MACRO ECONOMICS FACTORS AND BANK LENDING BEHAVIOUR IN INDONESIA

Field: Economics, Econometrics and Finance (Social Sciences)

AbstractThis study examines the influencing macro economics factor in lending distribution and observes the comparison of each factor based on lending type which are investment, working capital and domestic consumption lending. Using data of Indonesian commercial banks between 2003-2011 and a balanced panel method, it finds that bank liquidity and inflation rate have significant negative effect, while number of banks has strong positive influence to stimulate lending distribution. Moreover, saving rate and GDP growth were found not meaningfully contributed to change investment lending distribution, but they significantly influenced the other lending distribution. Lastly, reserve requirement and exchange rate did not significantly influence all lending type.Keywords: Loan, interest rate, growth, GDP.JEL Classification Numbers: G21, E43, E51AbstrakStudi ini meneliti faktor ekonomi makro yang mempengaruhi distribusi pinjaman dan mengamati perbandingan masing-masing faktor berdasarkan jenis pinjaman yaitu pinjaman investasi, modal kerja dan konsumsi. Dengan menggunakan data dari bank-bank komersial di Indonesia antara 2003-2011, dengan menggunakan analisis data panel, ditemukan bahwa likuiditas perbankan dan tingkat inflasi berpengaruh negatif signifikan, sedangkan jumlah bank berpengaruh positif dan kuat untuk mendorong distribusi pinjaman pada semua jenis pinjaman. Selain itu, tingkat tabungan dan pertumbuhan PDB ditemukan tidak bermakna dalam kontribusinya untuk mempengaruhi distribusi kredit investasi, tetapi secara signifikan mempengaruhi distribusi pinjaman lainnya. Terakhir, GWM dan nilai tukar tidak signifikan mempengaruhi semua tiga kategori jenis pinjaman. Keywords: Loan, interest rate, growth, GDPJEL Classification Numbers: G21, E43, E51
Multiparametric Large Field of View Rheumatology Imaging for Axial Spondyloarthropathy Detects Enthesitis in Setting of Inactive Sacroiliac Joint Disease and Impacts Clinical Diagnosis

Field: Medicine (Health Sciences)

Aim To test the diagnostic efficacy of a multiparametric rheumatology lumbosacral magnetic resonance (MR) imaging protocol in detection and characterization of axial spondylarthritis (SpA) and compare it with serology and clinical findings. Methods A consecutive series of multiparametric rheumatology lumbosacral MR imaging examinations performed on 3T MR scanner. Three-dimensional inversion recovery turbo spin echo, precontrast and postcontrast fat-suppressed T1-weighted images, as well as diffusion-weighted images were used to detect active erosions and enthesitis using established criteria. Pearson χ 2 was used for categorical variables. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were measured for magnetic resonance imaging (MRI) and serology, based on the final diagnosis from rheumatologists. An alpha error below 0.05 was considered statistically significant. Results The final study sample included 130 consecutive patients (80 women and 50 men; mean ± SD 44 ± 13 and 45 ± 14 years, respectively). Seventy-eight subjects were diagnosed with axial SpA and 52 with non-SpA arthropathy. In the non-SpA group, 27 patients were diagnosed with osteoarthritis, 6 had unremarkable imaging, whereas 19 were considered as clinically undetermined. There was positive correlation between positive MRI results and SpA diagnosis ( P < 0.00001). No correlation existed between positive serology alone and SpA diagnosis ( P = 0.0634). Although MRI and serology proved equally sensitive in detecting SpA, the specificity and overall accuracy of MRI were significantly higher. Inflammatory activity was detected in 45 (57.7%) cases, in the pelvic enthesis in 29 (37.2%) cases, in the lumbosacral spine in 16 (20.5%) cases, in the hip joints in 15 (19.2%) cases, and in the pubic symphysis in 5 (6.4%). Inactive sacral disease was seen in 7 of 35 enthesitis patients (20.0%), and in 2 SpA cases, there were no sacral lesions. Conclusions The results suggest that in patients with suspected SpA, MRI should not be limited to the sacroiliac joints, but also include enthesitis sites and other joints of the axial skeleton. The multiparametric rheumatology protocol increases the efficacy of MRI in detecting enthesitis and joint inflammatory disease, thereby offering additional information to the clinician and assisting in the early diagnosis/detecting disease activity.
Tree conservation can be constrained by agents from conservation permitting and funding agencies

Field: Environmental Science (Physical Sciences)

Recent conservation actions for Serianthes nelsonii Merr. and Cycas micronesica K.D. Hill in the Mariana Islands have illuminated some negative consequences associated with ill-informed agents representing permitting and funding agencies. Several cases from the islands of Guam and Tinian are discussed as ineffective conservation examples, and these are countered with two examples of successful conservation approaches. When biologists that act as points of contact for federal permitting and funding agencies do not possess education, knowledge, and experience that is germane to federally listed species, sound science may be marginalized from the conservation agenda. When rapid turnover of federal conservation agents introduces dysfunction, discontinuities in collaborations may thwart success. When lapses in conservation contracts are allowed, short-term extemporary contracting approaches are utilized, and conservation practitioners that lack the ability to include an experimental approach to conservation actions are employed, the co-production of new knowledge to enable decision support tools for future decision-makers may be hindered.
Determining a Fair Border

Field: Mathematics (Physical Sciences)

Introduction. Suppose n countries border on a region the ownership of which is in dispute (Fig. 1). Is there a way of partitioning the disputed territory so each country receives a single piece adjacent to itself which it considers at least 1/n the total value of the territory, even though different parts of the territory may be valued differently by individual countries? The main purpose of this paper is to show that such fair borders always exist, under the quite natural assumption that each country's value of the territory is nonatomic (i.e., single points have value zero).
Emissions effect of financial development in the GCC: is the effect asymmetric?

Field: Economics, Econometrics and Finance (Social Sciences)

Abstract Obviously, financial development is one of the factors to consider in designing climate policies. We investigated the effects of financial development on co 2 emissions alongside income, total factor productivity, and international trade in Gulf Cooperation Council (GCC) countries. Ignoring common factors can lead to erroneous findings and misleading policy recommendations. The same consequences occur if the nature of a factor’s effects is incorrectly considered. Hence, the Asymmetric Pooled Mean Group augmented with common unobserved factors—a cutting-edge method allowing for the discovery of not only the features of the pooled panel but also the characteristics of each country—was applied to data from 1992 to 2021. Additionally, we accounted for key properties of the panel time series data—cross-sectional dependence, non-stationarity and heterogeneity. To our knowledge, there is no such application for GCC countries, and only one internationally. In designing climate policy measures, a few key findings of our research are worth considering. (i) policies should account for factors common to GCC countries, as ignoring them makes co 2 effects of financial development misleading. (ii) an upturn in financial development leads to less emissions than a downturn in it. This asymmetric effect implies that policies should boost financial development. (iii) co 2 in GCC countries may converge to an identical relationship in the long run implying that there are common climate initiatives and projects that GCC authorities should work on jointly.
Data from IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma

Field: Medicine (Health Sciences)

<div>Abstract<p><b>Purpose:</b> Glioblastoma is the most aggressive primary brain tumor in adults with a median survival of 15–20 months. Numerous approaches and novel therapeutics for treating glioblastoma have been investigated in the setting of phase III clinical trials, including a recent analysis of the immune checkpoint inhibitor, nivolumab (anti-PD-1), which failed to improve recurrent glioblastoma patient survival. However, rather than abandoning immune checkpoint inhibitor treatment for glioblastoma, which has shown promise in other types of cancer, ongoing studies are currently evaluating this therapeutic class when combined with other agents.</p><p><b>Experimental Design:</b> Here, we investigated immunocompetent orthotopic mouse models of glioblastoma treated with the potent CNS-penetrating IDO1 enzyme inhibitor, BGB-5777, combined with anti-PD1 mAb, as well as radiotherapy, based on our recent observation that tumor-infiltrating T cells directly increase immunosuppressive IDO1 levels in human glioblastoma, the previously described reinvigoration of immune cell functions after PD-1 blockade, as well as the proinflammatory effects of radiation.</p><p><b>Results:</b> Our results demonstrate a durable survival benefit from this novel three-agent treatment, but not for any single- or dual-agent combination. Unexpectedly, treatment efficacy required IDO1 enzyme inhibition in non-glioblastoma cells, rather than tumor cells. Timing of effector T-cell infiltration, animal subject age, and usage of systemic chemotherapy, all directly impacted therapy-mediated survival benefit.</p><p><b>Conclusions:</b> These data highlight a novel and clinically relevant immunotherapeutic approach with associated mechanistic considerations that have formed the basis of a newly initiated phase I/II trial for glioblastoma patients. <i>Clin Cancer Res; 24(11); 2559–73. ©2018 AACR</i>.</p></div>
Latent Tuberculosis Infection among a Large Cohort of Medical Students at a Teaching Hospital in Italy

Field: Medicine (Health Sciences)

The surveillance of latent tuberculosis infection (LTBI) in both healthcare workers and healthcare students is considered fundamental for tuberculosis (TB) prevention. The aim of the present study was to estimate LTBI prevalence and evaluate potential risk-factors associated with this condition in a large cohort of medical students in Italy. In a cross-sectional study, performed between March and December 2012, 1511 eligible subjects attending the Medical School of the University of Genoa, trained at the IRCCS San Martino-IST Teaching Hospital of Genoa, were actively called to undergo the tuberculin skin test (TST). All the TST positive cases were confirmed with an interferon-gamma release assay (IGRA). A standardized questionnaire was collected for multivariate risk analysis. A total of 1302 (86.2%) students underwent TST testing and completed the questionnaire. Eleven subjects (0.8%) resulted TST positive and LTBI diagnosis was confirmed in 2 (0.1%) cases. Professional exposure to active TB patients (OR 21.7, 95% CI 2.9–160.2;Pvalue 0.003) and previous BCG immunization (OR 28.3, 95% CI 3.0–265.1;Pvalue 0.003) are independently associated with TST positivity. Despite the low prevalence of LTBI among Italian medical students, an occupational risk of TB infection still exists in countries with low circulation of Mycobacterium tuberculosis .