jimnoneill/paper-to-field-training huggingface dataset:
Resonance Raman studies on the blue-green-colored bovine adrenal tyrosine 3-monooxygenase (tyrosine hydroxylase). Evidence that the feedback inhibitors adrenaline and noradrenaline are coordinated to iron.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Tyrosine 3-monooxygenase (tyrosine hydroxylase) is a non-heme iron, tetrahydropterin-dependent enzyme which catalyzes the rate-limiting step in the biosynthesis of catecholamines. The highly purified bovine adrenal enzyme contains an unusual blue-green chromophore with lambda max at around 700 nm (epsilon = 1.3 (mM subunit enzyme)-1 cm-1). On excitation at 605.2 nm, resonance-enhanced Raman vibrations are observed at 454, 494, 527, 604, 635, 835, 1130, 1271, 1320, 1426, and 1476 cm-1. The excitation profiles of the modes of 1276 and 1476 cm-1 (from 488 to 620 nm) follow the contour of the 700 nm absorption band. The vibrations observed strongly indicate the presence of a bidentate catecholamine-Fe(III) complex in the enzyme as isolated which gives rise to the characteristic charge-transfer transitions. This is further supported by the release of 0.11 +/- 0.04 mol of noradrenaline and 0.25 +/- 0.06 mol of adrenaline per mol of enzyme subunit on denaturation of the enzyme. The energies of the catecholate to Fe(III) charge-transfer transitions indicate a mixture of histidines and carboxylate(s) coordinated to the iron center in tyrosine hydroxylase. At neutral pH, the enzymatic activity was inhibited more than 50% by 10 microM dopamine, noradrenaline, and adrenaline. The high affinity of the catecholamines to the nonphosphorylated form of tyrosine hydroxylase may have significance in vivo since catecholamines are potent feedback inhibitors of the enzyme.
Editorial Commentary

Field: Medicine (Health Sciences)

No AccessUrology PracticeBusiness1 Sep 2022Editorial CommentaryThis article comments on the following:Cost Implications of Routine Preoperative Blood Typing and Crossmatching Prior to Robot-Assisted Laparoscopic Partial Nephrectomy Reza Ghavamian Reza GhavamianReza Ghavamian Northwell Health, Greenlawn, New York More articles by this author View All Author Informationhttps://doi.org/10.1097/UPJ.0000000000000331.02AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Commentary." Urology Practice, 9(5), p. 363 References 1. : Examining the utility and cost of routine type and screen prior to minimally invasive hysterectomy. JSLS 2021; 25: e2021.00020. Google Scholar 2. : Thirty-day typing and screening for patients undergoing elective surgery: experience at a large center. Transfusion 2006; 46: 348. Google Scholar © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsRelated articlesUrology Practice17 Jun 2022Cost Implications of Routine Preoperative Blood Typing and Crossmatching Prior to Robot-Assisted Laparoscopic Partial Nephrectomy Volume 9Issue 5September 2022Page: 363-363 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Reza Ghavamian Northwell Health, Greenlawn, New York More articles by this author Expand All Advertisement PDF DownloadLoading ...
The ethics of disgust: uncovering inequality in career guidance

Field: Arts and Humanities (Social Sciences)

Præsentation af eksempelforskning, der viser etiske dilemmaer og afgrundsdyb ulighed i vejledningsrelationen. Med udgangspunkt i "det ækle" som fænomen, diskuteres og undersøges denne grundlæggende følelse hos mennesket, dens udtryk og udsigelse, i den professionelle pædagogiske relation.
MOSES’ ANXIETY AND DEFENSE MECHANISM IN EXODUS: GODS AND KINGS MOVIE

Field: Arts and Humanities (Social Sciences)

Anxiety is part of the defense mechanism. Defense mechanisms are psychological strategies unconsciously used to defend a person from anxiety arising from unacceptable thoughts or feelings. This study found the types of Moses’ anxiety and investigate the defense mechanism that Moses employed in reducing his anxiety by employing Freud’s concept as the main theory. The design of this research was qualitative research with content analysis as its approach. As the data, this study employed words including narrations and dialogues that were taken from Exodus Gods and Kings’ movie script. This study showed that Moses character experienced three types of anxieties covering neurotic anxiety, moral anxiety, and realistic anxiety. Furthermore, Moses employed five types of the defense mechanism covering repression, formation, isolation, denial, and aggression. The conclusion of this research considered Moses character experienced neurotic anxiety when he identified a boy that represented as the authority figure who was punishing him. The moral anxiety experienced in four times, overall happened when he felt guilty and realistic anxiety experienced three times because he managed some threats from the outer world. Moreover, all these features of the defense mechanism used to cope with Moses’s anxious feeling. The implication of this research provided another point of view in seeing Exodus: Gods and Kings' movie as the portrayal of the way how people can't suffer anxiety easily because anxious feeling happened from many factors and how people tried to use the defense mechanism to reduce anxiety.
Study on Optimization of RAPD Reaction Conditions for Lilium

Field: Agricultural and Biological Sciences (Life Sciences)

The optimum RAPD reaction system for Lilium was established using RAPD amplification with six factors(DNA template,Mg2+,TaqDNA polymerase,primer,dNTPs and annealing temperature).The optimum RAPD reaction system(25 μL) contains 40 ng DNA template,1.5 mmol/L Mg2+,1.0 U TaqDNA polymerase,1.0 μmol/L RAPD primer and 200 μmol/L dNTPs.The suitable annealing temperature of primer E 13 was 37.3 ℃.The research laid the foundation for RAPD analysis on studies of germplasm resources identification and genetic diversity in Lilium.
Revealing Expressiveness: The Demand Revealing Process with Expressive Voters

Field: Economics, Econometrics and Finance (Social Sciences)

Meetings for useful comments and discussion. The standard disclaimer applies. The demand revealing process (DRP) enjoys a rich tradition in the public choice literature as a superior mechanism for inducing truthful preference revelation and thereby achieving optimal provision of public goods. Tideman and Tullock’s (1976) application of the Clarke (1971) procedure as a social choice mechanism sparked a period of
Reply to “Comment on ‘Perturbative operator approach to high-precision light-pulse atom interferometry' ”

Field: Physics and Astronomy (Physical Sciences)

Recently, we introduced [C. Ufrecht and E. Giese, Phys. Rev. A 101, 053615 (2020)] a technique to calculate the phase of light-pulse atom interferometers caused by the presence of perturbation potentials and underlined its power by an illustrative example. In the preceding Comment [B. Dubetsky, Phys. Rev. A 102, 027301 (2020)], it was pointed out that other, less idealized situations could have been calculated as well. Our Reply emphasizes that our method is correct, the results from our example can be trivially generalized to other perturbations, and intricate effects of local environments can be even more prominent but also treated by our technique.
Safe operating area considerations in LDMOS transistors

Field: Engineering (Physical Sciences)

The trade-off between breakdown voltage and on-resistance is a well-known feature of both lateral and vertical DMOS transistors. The trade-offs and restrictions imposed by the "safe operating area" are less familiar. The SOA defines limits on the excursion of the operating point in the I/sub d/-V/sub ds/ plane. To be correct, the SOA should also include thermal limitations; however, these can be treated separately. In this paper, we focus on the "electrical SOA", which is defined by a specific boundary line in the I/sub d/-V/sub ds/ plane. Although the LDMOS SOA has been discussed in a number of papers, the details of the device physics that determine the SOA boundary are still somewhat unclear and further work is needed. The main purpose of this paper is to investigate device behaviour in the neighborhood of the SOA boundary and then use these results to predict the SOA. We consider devices with and without drain extensions using a self-aligned body diffusion. The predicted SOA is shown to be in good agreement with measurements for both types of LDMOS. Current flow within the device is examined in detail. The observed SOA is shown to be consistent with the silicon power density limit, a fundamental characteristic of silicon devices. Finally, we show how a simplified two-terminal model of the drain region can be used to demonstrate the behaviour of the LDMOS as it approaches snap-back. This approach is analogous to that previously used to model the onset of avalanche initiated second breakdown in bipolar transistors (hower and Reddi, 1970).
A Digital Compressed Sensing-Based Energy-Efficient Single-Spot Bluetooth ECG Node

Field: Engineering (Physical Sciences)

Energy efficiency is still the obstacle for long-term real-time wireless ECG monitoring. In this paper, a digital compressed sensing- (CS-) based single-spot Bluetooth ECG node is proposed to deal with the challenge in wireless ECG application. A periodic sleep/wake-up scheme and a CS-based compression algorithm are implemented in a node, which consists of ultra-low-power analog front-end, microcontroller, Bluetooth 4.0 communication module, and so forth. The efficiency improvement and the node’s specifics are evidenced by the experiments using the ECG signals sampled by the proposed node under daily activities of lay, sit, stand, walk, and run. Under using sparse binary matrix (SBM), block sparse Bayesian learning (BSBL) method, and discrete cosine transform (DCT) basis, all ECG signals were essentially undistorted recovered with root-mean-square differences (PRDs) which are less than 6%. The proposed sleep/wake-up scheme and data compression can reduce the airtime over energy-hungry wireless links, the energy consumption of proposed node is 6.53 mJ, and the energy consumption of radio decreases 77.37%. Moreover, the energy consumption increase caused by CS code execution is negligible, which is 1.3% of the total energy consumption.
Cool-Season Weed Control Using Ammonium Nonanoate and Cultivation in Organic Vidalia® Sweet Onion Production

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Ammonium nonanoate is registered for weed control in certified organic cropping systems and may be useful to control cool-season weeds in organic Vidalia® sweet onion production. Ammonium nonanoate combined with tine-weeder cultivation was evaluated for weed control in organic onion in Georgia. There were no statistical interactions between main effects of herbicides and cultivation with a tine weeder for cool-season weed control and onion yield, indicating that ammonium nonanoate does not improve weed control compared with cultivation. Ammonium nonanoate at 4% and 6% did not adequately control weeds and onion yields were reduced. Ammonium nonanoate at 8% and 10% controlled cutleaf evening-primrose and lesser swinecress equal to the standard of d -limonene (14%), but the degree of control did not consistently protect onion yields from losses due to weeds. These results are in agreement with previous studies using clove oil and pelargonic acid. There is no advantage to using ammonium nonanoate for cool-season weed control in organic Vidalia® sweet onion production.
Influencing Public Health Policy through Action-Oriented Research: A Case Study of Lysol Abuse in Alberta

Field: Health Professions (Health Sciences)

Conventional approaches to health policy research have been criticized for generating findings of limited practical utility. In response to this concern, alternative research approaches have been developed which are more “action-oriented.” Using an action-oriented approach, the problem of Lysol abuse in Alberta was examined. Lysol, a household disinfectant, is consumed by chronic alcoholics for its alcohol content. The results of the study indicated that, because of Lysol's price and availability, several hundred individuals in the inner city of Alberta's capital drink the disinfectant on a regular basis. The release of these findings appear to have influenced a number of subsequent policy developments, including the introduction of new provincial legislation to regulate Lysol sales. These developments have had a positive effect in reducing the magnitude of the Lysol abuse problem. The results of this case study suggest that action-oriented research can be a useful technique.
Abstract B37: Prenylation inhibition induces cell death in NRAS mutant melanoma cells

Field: Medicine (Health Sciences)

Abstract While targeted therapeutic approaches are now available for the treatment of BRAF mutant melanomas, non-BRAF mutant melanoma still lacks this modality. In order to explore the potential of prenylation inhibition we investigated the response of NRAS or BRAF mutant and double wild-type melanoma to zoledronic acid treatment. Effect of zoledronic acid on proliferation, apoptosis and migration of melanoma cells as well as the activation of downstream elements of the RAS/RAF pathway were characterized in vitro. In vivo subcutaneous xenograft and spleen to liver colonization models were used to evaluate the influence of zoledronic acid treatment on primary tumor growth and metastatic potential of melanoma cells. Zoledronic acid significantly decreased proliferation in NRAS mutant cells as compared to BRAF mutant and double wild-type cells, in vitro. Similarly, TUNEL assay revealed apoptosis induction in an oncogenic mutation specific manner. In line with this finding, activation of ribosomal protein S6 was decreased. Unexpected activation of the downstream effector Erk1/2 and increase in migration was found in BRAF mutant cells. Zoledronic acid failed to show significant synergism with cytotoxic cisplatin or DTIC treatment in vitro. In vivo zoledronic acid did not inhibit the subcutaneous growth of melanoma cells irrespective of oncogenic mutations. In contrast, the lower dose of zoledronic acid resulted in significantly higher liver metastasis in double wild-type cells. Altogether our data demonstrates that prenylation inhibition may be a novel therapeutic approach in NRAS mutant melanoma. However, further investigations are needed to identify drugs that have appropriate pharmacological properties to efficiently target melanoma cells. Citation Format: Tamas Garay, Istvan Kenessey, Viktoria Laszlo, Jozsef Tovari, Walter Berger, Laszlo Kovacs, Jozsef Timar, Balazs Hegedus. Prenylation inhibition induces cell death in NRAS mutant melanoma cells. [abstract]. In: Proceedings of the AACR Special Conference on RAS Oncogenes: From Biology to Therapy; Feb 24-27, 2014; Lake Buena Vista, FL. Philadelphia (PA): AACR; Mol Cancer Res 2014;12(12 Suppl):Abstract nr B37. doi: 10.1158/1557-3125.RASONC14-B37
The Suffering Body in Pepe Sales's Poetry

Field: Arts and Humanities (Social Sciences)

The poems of Pepe Sales (Barcelona, 1954-1994) are marked by his experience as a homosexual, drug addict and AIDS sufferer. He was a key member of the Barcelona counterculture, along with Pau Riba, Pau Malvido and Genís Cano, and has gone down in history as one of the poètes maudits of contemporary Catalan literature. The aim of this article is to analyse the representation of pain and distress in his poems and songs, with some additional references to his paintings. To this end, I draw on the critical work of Susan Sontag, Sara Ahmed, David Le Breton and Joanna Bourke, who conceive pain in general, not as a private and personal experience, but as a cultural and historical event that creates identity and community bonds. The main strategies used by Sales to convey his pain are the scream, animalisation, weapons and wounds and, especially, religious martyrdom. The basic finding is that the poet’s pain is not simply a testimony to the suffering of a lost generation of junkies and misfits that the official account of the transition from Francoism to democracy has stigmatised. On the contrary, it reminds us of an unfair medical, political and financial system that inflicted great suffering on them.
Interactions of a Dye and a Solvent with Poly(N-isopropylacrylamide) Gel in Relation to Its Phase-Transition Behavior

Field: Chemistry (Physical Sciences)

Abstract The binding of a dyestuff and the sorption of a solvent to a polymer gel have been studied in relation to the phase-transition behavior of the gel. Binding or sorption isotherms of a dye (erythrosine B) and a solvent (benzyl alcohol) to a polymer gel (poly(N-isopropylacrylamide) : NIPA) were measured and found first to be Langmuir- and BET-type curves, respectively. A single Langmuir-type adsorption isotherm and the superposition of the two isotherms of the dye were fit for the collapsed (40 °C) and swollen states (25 °C) of the gel, respectively. The phase-transition behavior of the NIPA gel was not affected at all by binding of the dye, but was highly altered by the addition of benzyl alcohol. A reentrant-type phase transition of the NIPA gel was observed with increasing concentration of benzyl alcohol at 25 °C. It is quite interesting to note that the gel shrinks when the concentration of the solvent inside the gel attains its solubility limit (ca. 0.4 mol dm-3), and swells again when it reaches the solubility in the bulk solution phase (outside the gel). At the stage of re-swelling, the solution in the gel interior consists of almost pure benzyl alcohol. These results indicate that the NIPA gel shows a selective sorption of benzyl alcohol, and separates it from its aqueous solutions.
"Strait Is the Gate": Byroads in Gide's Labyrinth

Field: Arts and Humanities (Social Sciences)

Destruction was my Beatrice! proclaimed Stephane Mallarme who preferred sonnets to cantos. His sometime disciple, Andre Gide-who similarly eliminated the explicit and therefore the superfluous in creating his finest works-wrote to Jacques Copeau that only craftsmanship mattered and that his only aspiration was to be a worthy artisan. In his preface to The Immoralist, Gide insisted that he sought to prove nothing, only to paint well and to give his painting proper lighting. For the many admirers of that carefully balanced narrative the opening lines of Strait is the Gate have been more than a little disconcerting:
Generation means analysis of seed yield and its components in canola

Field: Agricultural and Biological Sciences (Life Sciences)

To detect types of gene action especially epistasis for studied traits, six populations; P1, P2, F1, F2, BC1 and BC2 in two intraspecific crosses of canola (N.A.37 × Serw 4 and N.A.14 × Serw 6) were evaluated in a field trial during 2019/2020 season at Kafr-El-Hamam/Sharkia and Al-Arish/North Sinai Agricultural Research Stations, Agricultural Research Center, Egypt.Scaling and joint scaling tests revealed inadequacy of simple additive-dominance model in the inheritance of all studied traits in corresponding crosses at both locations.Significant negative heterosis and heterobeltiosis were found for days to first flower, plant height and first siliqua height, whereas significant positive were found for seed weight per plant and its components in the corresponding crosses at both locations.High to moderate values of narrow sense-heritability coupled with high (more than (20%) values of expected response from selection (as % of mean) were detected for days to the first flower in the 1 st cross at Kafr-El-Hamam and in the 2 nd cross at both locations, first siliqua height in the 1 st cross at both locations and in the 2 nd cross at Kafr-El-Hamam, 1000-seed weight in the 2 nd cross at Al-Arish and seeds weight per plant in the 1 st cross at both locations.The major role of dominance gene effects as the ratio ((H/D) 0.5 >1) along with the duplicate epistasis was detected in the inheritance of most studied traits in the corresponding crosses at both locations.Therefore, it is advisable to delay selection to advanced generation for improving most studied traits in most cases.
Near-field communication-based secure mobile payment service

Field: Computer Science (Physical Sciences)

The loss of customer account information makes headlines all too often. The Payment Card Industry (PCI) Data Security Standard (DSS) has generated resistance from merchants because of its cost and complexity. Unfortunately, innovating in the Point of Sale (PoS) space is hard because the protocols have been standardized, tightly constraining new ideas. Using mobile phones as payment devices opens up some opportunities, but any solution must minimize changes in the back-end processing. This paper describes a Near Field Communication (NFC) based mobile phone payment solution in a service-oriented environment, which provides the needed data protection without requiring costly changes to the payment processing infrastructure. In the payment transaction path, a personal mobile phone is viewed as a single, user-trusted touch point. Compared to other solutions available, our approach better protects user credentials, provides better user control over the transaction, and supports both proximity and remote transactions. The prototype has been integrated with an instore kiosk application and a HP multi-channel banking platform to demonstrate its value in the retail environment.
Coxiella burnetii in cattle and their human contacts in a gaushala (cattle shelter) from India and its partial com1 gene sequence-based phylogenetic analysis

Field: Veterinary (Health Sciences)

Q fever caused by Coxiella burnetii is an important zoonosis and has great public health significance. A total of 905 clinical samples from 387 cattle [serum (n = 387); vaginal swabs (n = 387); milk (n = 131)] and 59 serum samples from humans were collected from gaushala (cattle shelter) and screened for anti-C. burnetii IgG antibodies in the sera using an indirect-ELISA kit. Further, the samples were tested for C. burnetii DNA employing TaqMan real-time and conventional PCR assays targeting the com1 gene. In ELISA, 9.56% and 6.78% of animal and human sera samples were positive for anti-C. burnetii antibodies, respectively. Upon pathogen detection, 3.87% sera, 1.81% vaginal swabs, and 6.87% milk samples from cattle tested positive in TaqMan real-time PCR and 1.55% sera, 0.52% vaginal swabs, and 3.05% milk samples were found positive in conventional PCR. In humans, one serum sample was positive in both the PCR assays. The PCR positive samples (n = 12) were partially sequenced and the phylogenetic tree was constructed using com1 gene sequences (n = 42) from a different host and geographical areas. The study highlights infection of cattle and their human contacts in gaushala and identifies relationships between strains identified in the gaushala and those in other parts of the globe.