jimnoneill/paper-to-field-training huggingface dataset:
Teneligliptin Exerts Antinociceptive Effects in Rat Model of Partial Sciatic Nerve Transection Induced Neuropathic Pain

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Neuropathic pain (NP), is a chronic pain resulting from nerve injury, with limited treatment options. Teneligliptin (TEN) is a dipeptidyl peptidase-4 inhibitor (DPP-4i) approved to treat type 2 diabetes. DPP-4is prevent the degradation of the incretin hormone glucagon-like peptide 1 (GLP-1) and prolong its circulation. Apart from glycemic control, GLP-1 is known to have antinociceptive and anti-inflammatory effects. Herein, we investigated the antinociceptive properties of TEN on acute pain, and partial sciatic nerve transection (PSNT)-induced NP in Wistar rats. Seven days post PSNT, allodynia and hyperalgesia were confirmed as NP, and intrathecal (i.t) catheters were implanted and connected to an osmotic pump for the vehicle (1 μL/h) or TEN (5 μg/1 μL/h) or TEN (5 μg) + GLP-1R antagonist Exendin-3 (9–39) amide (EXE) 0.1 μg/1 μL/h infusion. The tail-flick response, mechanical allodynia, and thermal hyperalgesia were measured for 7 more days. On day 14, the dorsal horn was harvested and used for Western blotting and immunofluorescence assays. The results showed that TEN had mild antinociceptive effects against acute pain but remarkable analgesic effects against NP. Furthermore, co-infusion of GLP-1R antagonist EXE with TEN partially reversed allodynia but not tail-flick latency. Immunofluorescence examination of the spinal cord revealed that TEN decreased the immunoreactivity of glial fibrillary acidic protein (GFAP). Taken together, our findings suggest that TEN is efficient in attenuation of PSNT-induced NP. Hence, the pleiotropic effects of TEN open a new avenue for NP management.
LPG-Fueled Vehicles: An Overview of Technology and Market Trend

Field: Energy (Physical Sciences)

This article presents an overview of the technology status and market trends of LPG-fueled vehicles through the literature approach to re-evaluate their future. In the review, it is discovered that LPG vehicles are globally increasing, though with a concentration in some countries. Of the 25 countries included in the World LPG Association (WLPGA) annual report 2018, Turkey, Poland, India, Ukraine, and Mexico are the countries with the best LPG vehicle trends in average of 23%. Meanwhile, Australia, Japan, South Korea, United Kingdom, the Netherlands, France, and Germany with a long history of implementing LPG as an alternative fuel has experienced a decline in the 2013-2017 period by 17%. This was allegedly due to the penetration of diesel-fueled vehicles over the last ten years. Moreover, developed countries experiencing decline have succeeded in developing electric-based vehicles such as Hybrid Electric Vehicle (HEV), Plug-in hybrid electric vehicle (PHEV), Battery Electric Vehicles (BEV), and Fuel Cell Electric Vehicles (FCEV) due to stringent demands for emission standards.
TNFAIP3 mutation is an independent poor overall survival factor for patients with T‐cell acute lymphoblastic leukemia

Field: Medicine (Health Sciences)

Abstract Background It is imperative to explore potential biomarkers for predicting clinical outcome and developing targeted therapies for T‐cell acute lymphoblastic leukemia (T‐ALL). This study aimed to investigate the mutation patterns of tumor necrosis factor‐alpha‐inducing protein 3 ( TNFAIP3 , also known as A20 ) and its role in the prognosis of T‐ALL patients. Methods Polymerase chain reaction (PCR) and Sanger sequencing data from T‐ALL ( n = 49, JNU) and targeted sequencing data from T‐ALL ( n = 54, NFH) in our clinical center and a publicly available dataset ( n = 121, PRJCA002270), were used to detect TNFAIP3 mutation. Results Three TNFAIP3 single nucleotide polymorphisms (SNPs; g.3033 C > T, g.3910 G > A, and g.3904 A > G) were detected in T‐ALL in the JNU dataset, and g.3033 C > T accounted for the highest proportion, reaching 60% (6/10). Interestingly, TNFAIP3 mutation mainly occurred in adults but not pediatric patients in all three datasets (JNU, NFH, and PRJCA002270). T‐ALL patients carrying a TNFAIP3 mutation were associated with a trend of poor overall survival (OS) ( p = 0.092). Moreover, TNFAIP3 mutation was also an independent factor for OS for T‐ALL patients ( p = 0.008). Further subgroup analysis suggested that TNFAIP3 mutation predicted poor OS for T‐ALL patients who underwent chemotherapy only ( p < 0.001), and it was positively correlated with high risk and early T‐cell precursor ALL (ETP‐ALL) in two independent validation datasets (NFH and PRJCA002270). Conclusion TNFAIP3 mutation mainly occurs in adult T‐ALL patients, and it was associated with adverse clinical outcomes for T‐ALL patients; thus, it might be a biomarker for prognostic stratification.
Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

A DNA region not associated with conventional immunoglobulin gene rearrangement is rearranged in many lymphoid tumors. This region, designated here as lymphoid rearranging (LyR) DNA, was cloned from plasmacytoma J558 in which it had recombined 5' to a constant (C) region of the alpha heavy (H) chain gene, C alpha, within a switch (S) region, S alpha, involved in the switching of CH genes. Sequence determination established that LyR DNA had recombined within a S alpha recombination unit. LyR DNA does not originate from the H chain locus, and discordance between LyR DNA and CH copy number in certain lines suggests that LyR DNA probably derives from another chromosome. LyR DNA rearrangement is a characteristic of tumors of mature B cells; it was detected in 24 of 28 plasmacytomas and B-cell lymphomas, usually as LyR-S alpha, but not in 11 Abelson retrovirus-induced lymphomas of B-cell precursors nor detectably in normal B cells. In contrast, rearrangement was observed in only 3 of 18 T-cell lymphomas, and none of seven nonlymphoid lines. Most tumor lines (49 of 52), whether lymphoid or not, contained a low level of polyadenylylated LyR transcript(s), but several new RNA species with differences in their 5' regions appeared in B-cell lines in which LyR DNA was rearranged, suggesting that rearrangement may activate a new promoter or mode of splicing. The results suggest that the LyR-S alpha rearrangement represents a translocation to chromosome 12 that alters expression of LyR-encoded genes; hence, it may have participated in lymphoid tumor oncogenesis.
[Positron emission tomography. A new measurement method for imaging of regional and biochemical parameters].

Field: Medicine (Health Sciences)

Positron emission tomography (PET) is a method for quantitative imaging of regional physiological and biochemical parameters. Positron emitting radioactive isotopes can be produced by a cyclotron, eg. the biologically important carbon (11C), oxygen (15O), and nitrogen (13N) elements. With the tomographic principle of the PET scanner the quantitative distribution of the administered isotopes can be determined and images can be provided as well as dynamic information on blood flow, metabolism and receptor function. In neurology PET has been used for investigations on numerous physiological processes in the brain: circulation, metabolism and receptor studies. In Parkinson's disease PET studies have been able to localize the pathology specifically, and in early stroke PET technique can outline focal areas with living but non-functioning cells, and this could make it possible to intervene in this early state. With positron emission tomography a quantitative evaluation of myocardial blood flow, glucose and fatty acid metabolism can be made as well as combined assessments of blood flow and metabolism. Combined studies of blood flow and metabolism can determine whether myocardial segments with abnormal motility consist of necrotic or viable tissue, thereby delineating effects of revascularisation. In the future it will probably be possible to characterize the myocardial receptor status in different cardiac diseases. The PET technique is used in oncology for clinical as well as more basic research on tumor perfusion and metabolism. Further, tumor uptake of positron labelled cytotoxic drugs might predict the clinical benefit of treatment.
Genetic Variation of Native <em>Perilla</em> Germplasms Collected from South Korea Using SSR Markers and Morphological Characteristics

Field: Agricultural and Biological Sciences (Life Sciences)

Using morphological characteristics and SSR markers, we evaluated the morphological and genetic variation of 200 Perilla accessions collected from the five regions of South Korea and other region. In morphological characteristics analysis, particularly, leaf color, stem color, degree of pubescence, leaf size were found to be useful for distinguishing the characteristics of native Perilla accessions cultivated in South Korea. A total of 137 alleles were identified in the 20 simple sequence repeat (SSR) markers, and the number of alleles per locus ranged from 3 to 13, and the average number of alleles per locus was 6.85. The average gene diversity (GD) was 0.649, with a range of 0.290-0.828. From analysis of SSR markers, accessions from the Jeolla-do and Gyeongsang-do regions showed comparatively high genetic diversity values compared with those from other regions in South Korea. In the unweighted pair group method with arithmetic mean (UPGMA) analysis, the 200 Perilla accessions were found to cluster into three major groups and an outgroup with a genetic similarity of 42%, and did not showed a clear geographic structure from the five regions of South Korea. Therefore, it is believed that landrace Perilla seeds are frequently exchanged by farmers through various routes between the five regions of South Korea. The results of this study are expected to provide useful information for conservation of these genetic resources and selection of useful resources for the development of varieties for seeds and leafy vegetables of cultivated var. frutescens of Perilla crop in South Korea.
Hypertension in the Elderly

Field: Medicine (Health Sciences)

Hypertension is a common finding in patients aged over 60 years, but the following questions need answering. How dangerous is it? Will lowering the blood pressure reduce the attendant risks? What is the 'cost' of such treatment in terms of side effects, drug-induced disease and health service finance? Two recently completed trials throw light on these problems: EWPHE (European Working Party on Hypertension in the Elderly), a European study based on hospital-clinic attenders, using a diuretic backed up with methyldopa; and HEP (randomized trial of treatment of Hypertension in Elderly Patients in Primary Care), based on general-practice screening in England and Wales using atenolol and bendrofluazide. The results of these trials were compared and the findings were broadly similar in the two studies. Some of the differences may be due to the different selection of patients. It is concluded that elderly patients with sustained blood pressures greater or equal to 170/90 mmHg would benefit from treatment by substantial reduction of stroke. Diuretics or beta-blockers, alone or together, are acceptable treatments in elderly subjects.
Peer Review #1 of "Probabilistic model based on circular statistics for quantifying coverage depth dynamics originating from DNA replication (v0.1)"

Field: Computer Science (Physical Sciences)

Background.With the development of DNA sequencing technology, static omics profiling in microbial communities, such as taxonomic and functional gene composition determination, has become possible.Additionally, the recently proposed in situ growth rate estimation method allows the applicable range of current comparative metagenomics to be extended to dynamic profiling.However, with this method, the applicable target range is presently limited.Furthermore, the characteristics of coverage depth during replication have not been sufficiently investigated. Results.We developed a probabilistic model that mimics coverage depth dynamics.This statistical model explains the bias that occurs in the coverage depth due to DNA replication and errors that arise from coverage depth observation.Although our method requires a complete genome sequence, it involves a stable to low coverage depth (>0.01×).We also evaluated the estimation using real wholegenome sequence datasets and reproduced the growth dynamics observed in previous studies.By utilizing a circular distribution in the model, our method facilitates the quantification of unmeasured coverage depth features, including peakedness, skewness, and degree of density, around the replication origin.When we applied the model to time-series culture samples, the skewness parameter, which indicates the asymmetry, was stable over time; however, the peakedness and degree of density parameters, which indicate the concentration level at the replication origin, changed dynamically.Furthermore, we demonstrated the activity measurement of multiple replication origins in a single chromosome.Conclusions.We devised a novel framework for quantifying coverage depth dynamics.Our study is expected to serve as a basis for replication activity estimation from a broader perspective using the statistical model.
Isolation and Identification of Native Strains of Entomopathogenic Fungi at Arteaga, Coahuila

Field: Agricultural and Biological Sciences (Life Sciences)

Entomopathogenic fungi are a broad group of microorganisms that help maintain pest abundance below economic levels in agroecosystems. Limited studies on native isolates of these biological control agents have been done in northern Mexico. Our research endeavors to expand on earlier work. Our primary objective was to collect natural enemies in the Arteaga Coahuila areas where apples, Malus pumila Miller, are grown and isolate and use morphological and molecular characteristics to identify strains of entomopathogenic fungi. Metarhizium anisopliae (Metchnikoff) Sorokin was the dominant genus with eight isolates, and Beauveria bassiana (Bals.-Criv.),had five with 99% identity to the described species at the Basic Local Alignment Search Tool (BLAST) gene bank, mainly at Los Lirios, followed by San Antonio de las Alazanas, and Huachichil with dominance from April through August.
Pulmonary manifestations of juvenile laryngotracheal papillomatosis

Field: Medicine (Health Sciences)

Juvenile laryngotracheal papillomatosis spreads to involve the lungs in less than 1% of cases, and when this occurs, the prognosis is poor. In seven such cases, the lung lesions, which appeared either solid or cystic on radiographs, proved to be benign squamous cell proliferations or papillomas, with central cavities containing debris or air. They seemed to grow centrifugally, using the alveolar walls as scaffolding with central coalescence and lung destruction. Papillomas spread inferiorly from the larynx by direct extension as far as the major bronchi, but rarely beyond. However, the parenchymal lesions were widely scattered, and some were subpleural. This discrepancy suggests that fragments become detached, particularly during endoscopic resection, and are carried down the airways by airflow. Those that lodge proximal to the respiratory bronchioles may be removed by mucociliary action and cough. Those that travel more distally are poorly cleared and may grow. If enough lung parenchyma is destroyed, the patient can develop symptoms of restrictive lung disease in addition to signs of upper airway obstruction.
Bioscience CBD Gummies [Bio science CBD Gummies] 2023 Must Watch Updated Price And Warning?

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

These are practical items which work to guarantee extraordinary strength and healthiness without making any secondary effects and withdrawal side effects.\n\n \n\nCBD chewy candies are regular, 100 percent protected and all around established edibles which are shown to be sound and unmistakably fit after broad exhibitions.
Study on triterpenoid and flavonoid contents of Rabdosiajaponica

Field: Chemistry (Physical Sciences)

Objective To extract and identify the chemical constituents of Rabdosia japonica.Methods The constituents were isolated and purified by chromatography on silica gel,Sephadex LH-20and HPLC.The structures of the compounds were determined by mass spectrometry(MS)and nuclear magnetic resonance(NMR)spectra1analysis.Results Totally 10 compounds were isolated and their structures were identified as four triterpenoids:oleanolic acid(1),ursolic acid(2), 2α-hydroxyursolic acid(3),2α,23-dihydroxyursolic acid(4);six flavonoids:quercetin(5),apiginin(6),luteolin(7),rutin(8),isorhamnetin(9),and tricin(10).Conclusion Isorhamnetin(9)and tricin(10)had been isolated from this plant for the first time
Implementing Communication Protocols Using Object-Oriented Techniques

Field: Computer Science (Physical Sciences)

In this paper, elements of an object-oriented implementation of the upper layer OSI protocols are presented. Our goal in the paper is two-fold. First, to communicate to software engineers, particularly those developing systems software, that object-oriented programming techniques facilitate and enhance the implementation of layered architectures. Second, to convey to language designers our experience using object-oriented language features in building communications protocols. We focus on the requirements for the upper layer OSI protocols and illustrate how inheritance, subtyping, and polymorphic function effect their implementation.
A Rapid r-Continuous Bits Matching Algorithm for Large-Scale Immunocomputing

Field: Computer Science (Physical Sciences)

R-continuous bits matching is the most fundamental and common-used rule in AIS, which is used to measure the similarity between detectors and strings to be detected. Usually the time complexity is proportional to the size of detectors used (denoted as NR). To improve the runtime detecting efficiency, a rapid r-continuous bits matching algorithm is presented in this paper. Our algorithm first produces location vectors before handling real detection. Location vectors record the position information of all possible r-bits patterns extracted from the detector set. When detecting a string, our algorithm just queries location vectors and no need to access the detectors in use. Time complexity of our algorithm in run-time detection period is O(l-r+1) which is a dramatically progress compared to the original time complexity O(N R .(l-r+1)). Furthermore, this time complexity is irrelevant to the size of detector set used. This valuable characteristic makes it especially suitable for large-scale immunocomputing where NR may be very large.
The Cerebral Vasoactive Effects of Fentanyl, Sufentanil, and Alfentanil

Field: Neuroscience (Life Sciences)

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New Concepts in the Abstract Format of the Compositional Interchange Format?

Field: Computer Science (Physical Sciences)

Abstract: The compositional interchange format for hybrid systems (CIF) supports inter-operability of a wide range of tools by means of model transformations to and from the CIF. Work on the CIF takes place in the FP7 Multiform project, and in several other European projects. The CIF consists of an abstract and a concrete format, used for defining a formal semantics and for modeling, respectively. This paper discusses the results of a redesign of the abstract format as previously published, leading to the following main changes: variables are introduced using scoping operators; the abstract language is made more orthogonal by providing an operator for each concept in the language; parallel composition has been defined in such a way that compositional verification (assume/guarantee reasoning) is supported; and the concept of urgent actions has been properly defined. As a result, the expressivity and semantics of the abstract language have been considerably improved.
The efficient market hypothesis and rational expectations macroeconomics. How did they meet and live (happily) ever after?

Field: Economics, Econometrics and Finance (Social Sciences)

This paper benefitted, at an early stage, of the helpful and encouraging comments from Aurélien Goutsmedt, Mauro Boianovsky, and Ed Nelson. We are also grateful for the suggestions we have received in a number of seminars and conferences while presenting our work, notably the A. O. Hirschman seminar (Université Paris 1 Panthéon-Sorbonne), the 2019 History of Economics Society Annual Conference in New York, and the University of the West of England Economics Seminar. This version of our work has been greatly improved by the remarks of two anonymous referees; we thank them both for their careful reading and suggestions.
Management of severe pre-eclampsia

Field: Medicine (Health Sciences)

Hypertensive disorders are the most common medical complication of pregnancy, affecting 6–8% of all pregnancies (National High Blood Pressure Working Group, 2000). Approximately 30% of hypertensive disorders in pregnancy are due to chronic hypertension and 70% are due to gestational hypertension–pre-eclampsia. The spectrum of disease ranges from mildly elevated blood pressures with minimal clinical significance to severe hypertension and multi-organ dysfunction.