jimnoneill/paper-to-field-training huggingface dataset:
NeuroEPO plus (NeuralCIM®) in mild-to-moderate Alzheimer's clinical syndrome: the ATHENEA randomized clinical trial

Field: Medicine (Health Sciences)

Abstract Background NeuroEPO plus is a recombinant human erythropoietin without erythropoietic activity and shorter plasma half-life due to its low sialic acid content. NeuroEPO plus prevents oxidative damage, neuroinflammation, apoptosis and cognitive deficit in an Alzheimer's disease (AD) models. The aim of this study was to assess efficacy and safety of neuroEPO plus. Methods This was a double-blind, randomized, placebo-controlled, phase 2–3 trial involving participants ≥ 50 years of age with mild-to-moderate AD clinical syndrome. Participants were randomized in a 1:1:1 ratio to receive 0.5 or 1.0 mg of neuroEPO plus or placebo intranasally 3 times/week for 48 weeks. The primary outcome was change in the 11-item cognitive subscale of the AD Assessment Scale (ADAS-Cog11) score from baseline to 48 weeks (range, 0 to 70; higher scores indicate greater impairment). Secondary outcomes included CIBIC+, GDS, MoCA, NPI, Activities of Daily Living Scales, cerebral perfusion, and hippocampal volume. Results A total of 174 participants were enrolled and 170 were treated (57 in neuroEPO plus 0.5 mg, 56 in neuroEPO plus 1.0 mg and 57 in placebo group). Mean age, 74.0 years; 121 (71.2%) women and 85% completed the trial. The median change in ADAS-Cog11 score at 48 weeks was −3.0 (95% CI, −4.3 to −1.7) in the 0.5 mg neuroEPO plus group, −4.0 (95% CI, −5.9 to −2.1) in the 1.0 mg neuroEPO plus group and 4.0 (95% CI, 1.9 to 6.1) in the placebo group. The difference of neuroEPO plus 0.5 mg vs. placebo was 7.0 points (95% CI, 4.5–9.5) P = 0.000 and between the neuroEPO plus 1.0 mg vs. placebo was 8.0 points (95% CI, 5.2–10.8) P = 0.000. NeuroEPO plus treatment induced a statistically significant improvement in some of clinical secondary outcomes vs. placebo including CIBIC+, GDS, MoCA, NPI, and the brain perfusion. Conclusions Among participants with mild-moderate Alzheimer's disease clinical syndrome, neuroEPO plus improved the cognitive evaluation at 48 weeks, with a very good safety profile. Larger trials are warranted to determine the efficacy and safety of neuroEPO plus in Alzheimer's disease. Trial registration https://rpcec.sld.cu Identifier: RPCEC00000232.
ChemInform Abstract: Pentacoordinated Molecules. Part 69. Steric Hindrance in Pentacoordinated Fluorosilicates. Synthesis and Molecular Structure of the Diphenyl‐1‐naphthyldifluorosilicate Anion and the Phenylmethyltrifluorosilicate Anion.

Field: Chemistry (Physical Sciences)

Abstract The title anions are prepared according to the reaction scheme and are isolated as their ammonium salts (III) or tris(dimethylamino)sulfonium salt (VII).
Energy performance of compressed biogas production from co-digestion of Salix and dairy manure: factoring differences between Salix varieties

Field: Energy (Physical Sciences)

Abstract Biogas from anaerobic digestion is a versatile energy carrier that can be upgraded to compressed biogas (CBG) as a renewable and sustainable alternative to natural gas. Organic residues and energy crops are predicted to be major sources of bioenergy production in the future. Pre-treatment can reduce the recalcitrance of lignocellulosic energy crops such as Salix to anaerobic digestion, making it a potential biogas feedstock. This lignocellulosic material can be co-digested with animal manure, which has the complementary effect of increasing volumetric biogas yield. Salix varieties exhibit variations in yield, composition and biomethane potential values, which can have a significant effect on the overall biogas production system. This study assessed the impact of Salix varietal differences on the overall mass and energy balance of a co-digestion system using steam pre-treated Salix biomass and dairy manure (DaM) to produce CBG as the final product. Six commercial Salix varieties cultivated under unfertilised and fertilised conditions were compared. Energy and mass flows along this total process chain, comprising Salix cultivation, steam pre-treatment, biogas production and biogas upgrading to CBG, were evaluated. Two scenarios were considered: a base scenario without heat recovery and a scenario with heat recovery. The results showed that Salix variety had a significant effect on energy output-input ratio (R), with R values in the base scenario of 1.57–1.88 and in the heat recovery scenario of 2.36–2.94. In both scenarios, unfertilised var. Tordis was the best energy performer, while the fertilised var. Jorr was the worst. Based on this energy performance, Salix could be a feasible feedstock for co-digestion with DaM, although its R value was at the lower end of the range reported previously for energy crops.
Impact of repeat flooding on mental health and health-related quality of life: a cross-sectional analysis of the English National Study of Flooding and Health

Field: Health Professions (Health Sciences)

Objective To assess the association between flooding/repeat flooding and: (1) psychological morbidity (anxiety, depression, post-traumatic stress disorder (PTSD)) and (2) health-related quality of life (HRQoL) at 6 months post-flooding. Design Cross-sectional analysis of data from the English National Study of Flooding and Health. Setting Cumbria, England. Participants Questionnaires were sent to 2500 residential addresses at 6 months post-flooding; 590 people responded. Outcomes Probable depression was assessed using the Patient Health Questionnaire, probable anxiety using the Generalised Anxiety Disorder scale and probable PTSD using the short-form PTSD checklist (PCL-6). HRQoL was assessed using the EQ-5D-5L. Mental health outcomes were analysed using logistic regression; HRQoL dimensions using ordinal regression; and summary index/Visual Analogue Scale scores using linear regression. Results One hundred and nineteen participants had been flooded, over half of whom were experiencing a repeat flooding event (54%; n=64). Mental health outcomes were elevated among flooded compared with unaffected participants (adjusted OR for probable depression: 7.77, 95% CI: 1.51 to 40.13; anxiety: 4.16, 95% CI: 1.18 to 14.70; PTSD: 14.41, 95% CI: 3.91 to 53.13). The prevalence of depression was higher among repeat compared with single flooded participants, but this was not significant after adjustment. There was no difference in levels of anxiety or PTSD. Compared with unaffected participants, those flooded had lower EQ-5D-5L index scores (adjusted coefficient: −0.06, 95% CI: −0.12 to −0.01) and lower self-rated health scores (adjusted coefficient: −6.99, 95% CI: −11.96 to −2.02). There was, however, little difference in HRQoL overall between repeat and single flooded participants. Conclusions Interventions are needed to help minimise the impact of flooding on people’s mental health and HRQoL.
A monocular visual SLAM system augmented by lightweight deep local feature extractor using in-house and low-cost LIDAR-camera integrated device

Field: Computer Science (Physical Sciences)

Simultaneous Localization and Mapping (SLAM) has been widely used in emergency response, self-driving and city-scale 3D mapping and navigation. Recent deep-learning based feature point extractors have demonstrated superior performance in dealing with the complex environmental challenges (e.g. extreme lighting) while the traditional extractors are struggling. In this paper, we have successfully improved the robustness and accuracy of a monocular visual SLAM system under various complex scenes by adding a deep learning based visual localization thread as an augmentation to the visual SLAM framework. In this thread, our feature extractor with an efficient lightweight deep neural network is used for absolute pose and scale estimation in real time using the highly accurate georeferenced prior map database at 20cm geometric accuracy created by our in-house and low-cost LiDAR and camera integrated device. The closed-loop error provided by our SLAM system with and without this enhancement is 1.03m and 18.28m respectively. The scale estimation of the monocular visual SLAM is also significantly improved (0.01 versus 0.98). In addition, a novel camera-LiDAR calibration workflow is also provided for large-scale 3D mapping. This paper demonstrates the application and research potential of deep-learning based vision SLAM with image and LiDAR sensors.
ChemInform Abstract: Homogeneous Catalytic Asymmetric Hydrogenolysis of Sodium Epoxysuccinate: The First Example of Asymmetric Hydrogenolysis of an Epoxide.

Field: Chemistry (Physical Sciences)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Assessing the Interactions between Strengths and Risk Factors of Recidivism through the Structured Assessment of Violence Risk in Youth (SAVRY)

Field: Psychology (Social Sciences)

Instruments that assess recidivism risk in young people are used widely in the sphere of juvenile justice worldwide. Traditionally, research has focused on the study of risk factors presented by young offenders, and how these relate to criminal recidivism. In present-day research, protective factors have also come into their own, having proven to encourage non-recidivism in young offenders. This paper presents a study carried out with 594 young offenders. The instrument used for assessing risk of recidivism in young offenders was the Structured Assessment of Violence Risk in Youth (SAVRY). In the results found here, one can observe how the young offenders who did not reoffend presented a greater level of protective factors than the repeating offenders. The youths with a prior arrest record scored higher in the risk domains than the reoffenders without a prior arrest record. The case of young repeat offenders who already had an arrest record represents a high-risk profile, or a profile of a criminal career. Crimes committed by young people can be isolated incidents in their life. In most youths, criminal behavior does not persist beyond legal age. Protective factors prove to be important in juvenile justice when planning an individualized intervention for the young offender.
Ship model self-propulsion instrument development and test verification

Field: Engineering (Physical Sciences)

Abstract Aimed at the characteristics of high precision requirements and large environmental changes of the thrust and torque coupling test in the self-propulsion test of the ship model, the paper carries out the design of the instrument of the ship model test, the calculation of structural strength, the design of anti-jamming of the thrust and torque coupling, and the selection and realization of thrust and torque module. Based on the above, the instrument was calibrated with sensitivity coefficient, high and low temperature, and dynamic stability tests. Besides this, a self-propulsion test at the design speed point of a ship was carried out to verify the accuracy and environmental adaptability. From the static calibration result, the coefficient of determination is 1.0. The max zero drift of thrust and torque is 0.11% FS and 0.05% FS respectively from the low-high temperature test, and the max zero drift of torque under different revolutions is 0.23% FS from the dynamic test. In addition to the above, the max deviation between Maric-SP01 and R31 of thrust and torque is less than 0.78% and 0.65% respectively from the ship model self-propulsion test. So, in one word, the instrument has good reliability and accuracy and can meet the requirements of the ship model self-propulsion test.
The magnetic structures of dilute Cr-Mn alloys

Field: Physics and Astronomy (Physical Sciences)

Single crystals of chromium-manganese alloys containing 0.12, 0.44 and 1.03 wt% Mn have been grown and their magnetic structures determined from 78 °K to their respective Néel temperatures. Measurements of the susceptibility of these crystals and of Young's modulus of the polycrystalline material have also been made over the same temperature ranges. The data confirm earlier magnetic structure work on polycrystalline material, and serve to illustrate a theory due to Tachiki and Nagamiya originally proposed to explain the antiferromagnetism of chromium.
Model-Based Probabilistic Robust Design With Data-Based Uncertainty Compensation for Partially Unknown System

Field: Decision Sciences (Social Sciences)

Model uncertainty often results from incomplete system knowledge or simplification made at the design stage. In this paper, a hybrid model/data-based probabilistic design approach is proposed to design a nonlinear system to be robust under the circumstances of parameter variation and model uncertainty. First, the system is formulated under a linear structure which will serve as a nominal model of the system. All model uncertainties and nonlinearities will be placed under a sensitivity matrix with its bound estimated from process data. On this basis, a model-based robust design method is developed to minimize the influence of parameter variation in relation to performance covariance. Since this proposed design approach possesses both merits from the model-based robust design as well as from the data-based uncertainty compensation, it can effectively achieve robustness for partially unknown nonlinear systems. Finally, two practical examples demonstrate and confirm the effectiveness of the proposed method.
MOZART'S OVERTURE TO TITUS AS DRAMATIC ARGUMENT

Field: Arts and Humanities (Social Sciences)

MOZART'S OVERTURE TO TITUS AS DRAMATIC ARGUMENT Get access DANIEL HEARTZ DANIEL HEARTZ Search for other works by this author on: Oxford Academic Google Scholar The Musical Quarterly, Volume LXIV, Issue 1, January 1978, Pages 29–49, https://doi.org/10.1093/mq/LXIV.1.29 Published: 01 January 1978
Delayed identification of Bardet-Biedl syndrome

Field: Medicine (Health Sciences)

Bardet-Biedl syndrome is a central obesity syndrome with a hereditary link affecting non-motile cilia that can be diagnosed clinically. Central obesity and polydactyly are important phenotypic features of this syndrome. Most cases are identified in early childhood. The report discusses the retrospective diagnosis of Bardet-Biedl syndrome in a heart failure patient. On examination, the patient revealed central obesity, polydactyly, retinitis pigmentosa and an atrial septal defect. The involvement of multiple systems with phenotypic traits resulted in a syndromic association. The woman was treated conservatively for her symptoms with diuretics. Past hospital visits by the patient overlooked the diagnosis of Bardet-Biedl syndrome. This syndrome is diagnosed using the criteria established by Beales and colleagues. Although specific management strategies for treating the syndrome have yet to be proposed, diagnosis aids in genetic counselling for affected couples, metabolic syndrome management, blindness rehabilitation and early detection of organ damage, allowing for adequate follow-up.
EXPERIMENTS ON THE CULTIVATION OF SO CALLED TRACHOMA BODIES

Field: Medicine (Health Sciences)

1. An organism was isolated and studied in pure cultures from cases of conjunctivitis accompanied by the so called trachoma body inclusions, as well as from a case of old trachoma without inclusions. 2. This organism was not found in the cultures made from other forms of conjunctivitis in which the inclusions were absent. 3. The organism presents the morphological features characteristic of so called trachoma bodies. It undergoes an early transformation, during which the forms known as initial bodies appear, and a later change, during which forms resembling elementary granules arise, while certain intermediate forms between these occur simultaneously. 4. No definite cell inclusions could be produced in monkeys by inoculating pure cultures of the organism. 5. The cultivation of this organism from a case of trachoma without the cell inclusions, together with the previously ascertained fact that the inclusions can be produced in suitable animals by inoculating such material directly from a human case, suggests the possibility of the organism being still present in such cases of trachoma, although not in the form of cell inclusions. 6. The facts presented justify the statement that by a suitable method an organism resembling the various important stages of the trachoma bodies and totally distinct from the gonococcus has been obtained in a living condition, capable of indefinite cultivation from cases of human trachoma and inclusion conjunctivitis. Whether the organism and trachoma bodies are identical cannot be positively stated at present. But the way is now opened to determine this point, as well as the specificity of the trachoma bodies.
High Performance 400 °C p+/n Ge Junctions Using Cryogenic Boron Implantation

Field: Materials Science (Physical Sciences)

We report high performance Ge p(+)/n junctions using a single, cryogenic (-100 degrees C) boron ion implantation process. High activation >4 x 10(20) cm(-3) results in specific contact resistivity of 1.7 x 10(-8) Omega-cm(2) on p(+)-Ge, which is close to ITRS 15 nm specification (1 x 10(-8) Omega-cm(2)) and nearly 4.5x lower than the state of the art (8 x 10(-8) Omega-cm(2)). Cryogenic implantation is shown to enable solid-phase epitaxial regrowth and lower junction depth through amorphization of the surface Ge layer. These improvements in Ge p(+)/n junctions can pave the way for future high mobility Ge p-MOSFETs.
Optimize data association of point cloud to improve the quality of mapping and positioning

Field: Computer Science (Physical Sciences)

Purpose Accurate mapping is crucial for the positioning and navigation of mobile robots. Recent advancements in algorithms and the accuracy of LiDAR sensors have led to a gradual improvement in map quality. However, challenges such as lag in closing loops and vignetting at map boundaries persist due to the discrete and sparse nature of raster map data. The purpose of this study is to reduce the error of map construction and improve the timeliness of closed loop. Design/methodology/approach In this letter, the authors introduce a method for dynamically adjusting point cloud distance constraints to optimize data association (ODA-d), effectively addressing these issues. The authors propose a dynamic threshold optimization method for matching point clouds to submaps during scan matching. Findings Large deviations in LiDAR sensor point cloud data, when incorporated into the submap, can result in irreparable errors in correlation matching and loop closure optimization. By implementing a data association framework with double constraints and dynamically adjusting the matching threshold, the authors significantly enhance submap quality. In addition, the authors introduce a dynamic fusion method that accounts for both submap size and the distance between submaps during the mapping process. ODA-d reduces errors between submaps and facilitates timely loop closure optimization. Originality/value The authors validate the localization accuracy of ODA-d by examining translation and rotation errors across three open data sets. Moreover, the authors compare the quality of map construction in a real-world environment, demonstrating the effectiveness of ODA-d.
Schwannoma with an unusual anterior chest wall location: A rare case report

Field: Medicine (Health Sciences)

Chest wall schwannoma is a rare intercostal nerve tumor originating from Schwann cells. Here, we present a case of a 44-year-old woman who presented with symptoms of cough, fever, and left-sided chest pain. A plain chest radiograph was unremarkable and was further evaluated with a contrast-enhanced chest computed tomography (CECT) scan, which showed a well-defined, encapsulated soft-tissue mass in the left anterior first intercostal space. The diagnosis of schwannoma was based on histopathological and immunohistochemical studies of tissue biopsies taken from the lesion. The patient was referred to a higher oncology center for further treatment where he received symptomatic treatment for the pain and cough after which he improved. The patient was discharged and followed up in the clinic. Six months later, the patient underwent another chest CECT, which revealed no growth in size from the first one. Therefore, it was decided to keep the patient in regular follow-up since the lesion remained stable in size.
Appraisal of the General Studies (GST) Entrepreneurship Skills Acquisition Curriculum for University Undergraduates in Nigeria: Challenges and the Way Forward

Field: Social Sciences (Social Sciences)

The study analyzed entrepreneurship skills acquisition content of GST curriculum for undergraduates in Nigerian Universities. Four research questions guided the study. The population of the study was all the three hundred level students of 2011/2012 academic session who were exposed to the entrepreneurial skill GST curriculum. A sample of 400 students was used for the study. A 52- itemed questionnaire was used to collect data from the respondents. The instrument was validated by two experts from GST unit, and one from Measurement and Evaluation, all from Ebonyi State University, Abakaliki. The instrument yielded a reliability coefficient of 0.72 using Cronbach Alpha method. The results from the responses were analyzed using mean scores and percentages. The study findings showed that the students could not properly identify the content of general entrepreneurship curriculum, and were not exposed to the practical aspect of the skills; hence the low percentage recorded for those who are ready to practice the skills. They equally agreed that they would face the enlisted challenges in the practice of the skills. Based on the findings of the study, recommendations were made.
An Approach of Quality Performance Assessment Based on Cloud Model

Field: Decision Sciences (Social Sciences)

The criteria of GB/T 19580 are listed in form of linguistic term and its scoring system lacks of interim between adjacent grades. When the criteria are used in quality performance assessment, it will deal with large of qualitative indicators’ measurement and synthesis. The linguistic cloud model is introduced to implement the transition between qualitative criteria and quantitative measurement, and the evaluation approach of cloud center gravity is used to measure the change of multi-dimensional synthetic cloud. The degree of deviation θ is used to weigh the deflection between actual quality performance and best practice. Finally, a case is discussed to demonstrate the method proposed in this paper.
Dielektrische Messungen an polaren Gemischen. 6. Mitteilung Harnstoffe

Field: Chemistry (Physical Sciences)

Abstract The dielectric increments of substituted ureas in polar solvents are measured. The dipole moments and the correlation parameters are calculated and discussed. It is shown that the results are only explainable if cis ‐conformation of the alkyl substituent to the carbonyl group and a hydrogen bridge to the solvent are assumed. The frequency dependence of some solutions is measured and the relaxation times are calculated. It is possible to construct C OLE ‐arc‐plots for the solute from the real and the imaginary part of the increment. Measurements of the temperature dependence of the dielectric constant of tetraethyl‐urea shows the normal behaviour of a liquid without hydrogen bridges and without free rotation in the solid.