jimnoneill/paper-to-field-training huggingface dataset:
Abstract 7092: Cancer biomarker discovery with scalable biofluid proteomics

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Biofluid proteomics opens opportunities for the discovery of early detection, diagnostic, and prognostic cancer biomarkers through non-invasive or minimally invasive screening. Plasma and serum are accessible sample types, however, the high dynamic range of proteins creates analytical challenges for the sensitive detection of potential biomarkers. In this work, we compare two proteomic approaches for large-scale cancer biomarker discovery: the Olink Proximity Extension Assay and the Seer Proteograph Product Suite. Olink Explore 3072 is an immunoassay that gains specificity by using dual antibody recognition to measure approx. 3,000 proteins in each sample. Antibody pairs are tagged with oligonucleotides, which hybridize and are amplified before measurement by next generation sequencing. Seer Proteograph is an enrichment strategy that uses a proprietary mix of functionalized magnetic nanoparticles with affinity for certain amino acids and functional groups in native state proteins. The resulting peptides are measured using untargeted mass spectrometry to identify proteins at the peptide level, paving the way for the identification of proteoforms and peptide variants. Aliquots of human plasma from 78 samples representing a range of cancer indications were obtained through the Discovery Life Sciences biobank and used for analysis by both the Olink and Proteograph workflows. Olink analysis achieved Pearson correlation scores of greater than or equal to 0.8 when correlating each of seven process controls to each other for all approx. 3000 proteins. On average, greater than or equal to 75% of the proteins were detected across all panels in all sample groups except for Normal and Benign groups (64% and 74% respectively). After stringent FDR filtering to ensure only high-quality data was analyzed, the Seer Proteograph workflow quantified 4,323 proteins across all 78 samples. Pearson correlation scores of greater than or equal to 0.96 were achieved when comparing digestion controls, process controls, and sample cleanup controls. Both platforms achieved detection of proteins across the dynamic range of plasma, including low abundance proteins. The Olink Explore 3072 and Seer Proteograph platforms were found to be complementary, with approx. 15% overlap in measured proteins. Cancer biomarker discovery at the proteomic level is bolstered by recent advances in analytical capabilities, as revealed by the Olink Explore and Seer Proteograph platforms. Importantly, complementary implementation of these two workflows will enable comprehensive biomarker analysis. Citation Format: Danielle B. Gutierrez, Jessica L. Moore, Jaison Arivalagan, Tiffany Louie, Leslie Wilkinson, Ray Clemens. Cancer biomarker discovery with scalable biofluid proteomics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7092.
Trends in family planning and contraception carried out in primary health care in Croatia: 1995-2012: study based on routinely collected data.

Field: Health Professions (Health Sciences)

The lack of objective findings provided the reason to undertake this study with the main aim of exploring the trends in family planning and contraception carried out in primary health care in Croatia. Based on the Croatian health statistical yearbooks from 1995 to 2012, data were collected on the number and structure of visits and the number and type of prescribed contraceptives by public and private gynecological practices, and visits to family practices and school medicine services. The results showed that only a small number of fertile women received primary care for family planning issues, trends that are evident through the entire follow-up period. A trend of "migration" from the public to the private sector is also observed. Family doctors and school medicine are almost entirely excluded from the provision of family planning despite the magnitude of the family planning problem resulting in a waste of human and material resources.
The Effect of Walking Program on the Women in a Rural Community

Field: Health Professions (Health Sciences)

This study was performed to be used as basic data and to activate walking exercise by analyzing the study through twelve-week walking program of a rural community and developing an exercise program for health promotion suitable to the actual condition of a community.Twelve-week walking program was developed and implemented for the middle-aged and old 67 women in a rural community, and this survey was performed from June 26, 2006 to Sep 2, 2006.Data was analyzed using SPSS 12.0 program and body composition, physical fitness and blood pressure, stress and fatigue were compared before and after the walking through paired t-test.As for weight in body composition, the average weight was 53.6±7.2 kg before walking and 53.2±7.1 kg after walking (p<0.001).As for Body Mass Index, it was 24.9±3.9before and 24.7±3.9 after walking, which significantly decreased (p<
Multiagent Task Allocation in Complementary Teams: A Hunter-and-Gatherer Approach

Field: Computer Science (Physical Sciences)

Consider a dynamic task allocation problem, where tasks are unknowingly distributed over an environment. This paper considers each task comprising two sequential subtasks: detection and completion, where each subtask can only be carried out by a certain type of agent. We address this problem using a novel nature-inspired approach called “hunter and gatherer.” The proposed method employs two complementary teams of agents: one agile in detecting (hunters) and another skillful in completing (gatherers) the tasks. To minimize the collective cost of task accomplishments in a distributed manner, a game-theoretic solution is introduced to couple agents from complementary teams. We utilize market-based negotiation models to develop incentive-based decision-making algorithms relying on innovative notions of “certainty and uncertainty profit margins.” The simulation results demonstrate that employing two complementary teams of hunters and gatherers can effectually improve the number of tasks completed by agents compared to conventional methods, while the collective cost of accomplishments is minimized. In addition, the stability and efficacy of the proposed solutions are studied using Nash equilibrium analysis and statistical analysis, respectively. It is also numerically shown that the proposed solutions function fairly; that is, for each type of agent, the overall workload is distributed equally.
Influence of Kindergarten Curriculum on the Development of Creative Thinking Skills and Self-Efficacy among Kindergartners

Field: Social Sciences (Social Sciences)

The current study aimed to identify the influence of kindergarten curriculum on the development of creative thinking skills and self-efficacy among kindergartners. The study was applied on a sample of (93) male and female kindergartners in Al-Karak governorate whom were randomly selected. Torrance test of creative thinking and the self-efficacy assessment scale (localized into Arabic version by the authors of this study) were applied. The two instruments were applied at the early attendance of children to kindergarten and application was replicated at the end of the academic year. Results indicated no significant statistical differences between the two groups in the development of creative thinking or self-efficacy that are attributed to the influence of public and private curriculum. For gender variable, it was indicated that there were no significant statistical differences in self-efficacy while these differences existed in creative thinking in favor of females.
Effects of Soft-Wall Vibration and Radiation in a Dynamic Model of the Vocal Cords and Vocal Tract

Field: Computer Science (Physical Sciences)

At the previous meeting of the Society, we described a computer model of the vocal cords and vocal tract system in which dynamic, physiologically based control functions accomplish speech synthesis [J. L. Flanagan, K. Ishizaka, and K. Shipley, “Dynamic Control of a Computer Model of the Vocal Cords,” J. Acoust. Soc. Am. 54, 319(A) (1973)]. The model has been extended to include the effects of vibration and radiation of the soft walls of the vocal tract. The influence of yielding walls upon the mode structure (formants) of the vocal system, upon the cord-tract acoustic interaction, and upon sound output during total occlusion is studied and reported. Articulatory dynamics of an intervocalic, voiced labial stop are used as a vehicle to expose the detailed behavior of the model. During occulsion, wall yielding is shown to contribute to sustenance of voicing, and wall radiation accounts for sound output. A computer movie film, generated at a slow-motion rate of 100 times real time, illustrates the coordinated interplay of cord and tract motion.
Synthesis of Isoxazolo[5,4-b]pyridines by Microwave-Assisted Multi-Component Reactions in Water

Field: Chemistry (Physical Sciences)

A series of new polycyclic-fused isoxazolo[5,4-b]pyridines were obtained by a one-pot tandem reaction under microwave irradiation in water. Without any use of additional reagent or catalyst, the synthetic protocol represents a green one and makes this methodology suitable for library synthesis in drug discovery efforts.
Religion, Human Rights, and Global Culture: A Dozen Years Later

Field: Social Sciences (Social Sciences)

This article examines current human rights thinking through the lens of the sociology of religion. Though human rights law was intended to combat the positive-law tradition, which proved so amenable to Holocaust, it in fact amounts to a sacred history. Like all sacred texts, human rights documents provide both a way to separate good and evil, while also stimulating action. More interestingly, the three generations of human rights (civil/political, social/economic, and group/cultural) mirror three aspects of the contemporary global economic and political order. I wrote as much ten years ago, in my first article for Philosophical Alternatives. My previous view now requires correction. Third-generation human rights are now more clearly connected to a push against globalization on behalf of aroused ethno-religious communities. This undercuts human rights advocates rather Whiggish view of history.
Indirect Solid-Phase Microradioimmunoassay for Detection of Pseudorabies Virus Antibody in Swine Sera

Field: Veterinary (Health Sciences)

SUMMARY An indirect solid-phase microradioimmunoassay ( iria )was developed for detection and quantitation of antibodies to pseudorabies virus ( prv ) in swine serum. Qualitative results of the iria compared closely with results of the serum neutralization test ( nt ) and the microimmunodiffusion test ( midt ). The iria was more sensitive than the nt for detection of antibodies to prv in swine serum. The iria result is expressed numerically. With the iria and nt , antibody to prv was first detectable in 3 experimentally infected pigs at 9 days after inoculation. With the midt , antibody was detected in the 3 experimentally infected pigs at 7, 8, and 9 days after inoculation. The iria results are obtainable within a few hours; the nt and midt require 48 hours for completion.
Measurement-Based Modeling of Vehicle-to-Vehicle MIMO Channels

Field: Engineering (Physical Sciences)

Abstract — Vehicle-to-vehicle (VTV) communications are of interest for applications within traffic safety and congestion avoidance, but the development of suitable communications systems requires accurate models for VTV propagation channels. This paper presents a new wideband MIMO (multiple-inputmultiple-output) channel model for VTV channels based on extensive MIMO channel measurements performed at 5.2 GHz in rural environments in Lund, Sweden. The measured channel characteristics, in particular the non-stationarity of the channel statistics, motivate the use of a geometry-based stochastic channel model (GSCM) instead of the classical tapped-delay line model. We introduce generalizations of the generic GSCM approach and find it suitable to distinguish between diffuse and discrete scattering contributions. The time-variant contributions from discrete scatterers are tracked over time and delay using a high resolution algorithm, and our observations motivate their power being modeled as a combination of a deterministic part and a stochastic part. The paper gives a full model parameterization and the model is verified by comparison of MIMO antenna correlations derived from the channel model to those obtained directly from measurements. I.
Metastable HIV-1 Surface Protein Env Sensitizes Cell Membranes to Transformation and Poration by Dual-Acting Virucidal Entry Inhibitors

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Dual-acting virucidal entry inhibitors (DAVEIs) have previously been shown to cause irreversible inactivation of HIV-1 Env-presenting pseudovirus by lytic membrane transformation. This study examined whether this transformation could be generalized to include membranes of Env-presenting cells. Flow cytometry was used to analyze HEK293T cells transiently transfected with increasing amounts of DNA encoding JRFL Env, loaded with calcein dye, and treated with serial dilutions of microvirin (Q831K/M83R)-DAVEI. Comparing calcein retention against intact Env expression (via Ab 35O22) on individual cells revealed effects proportional to Env expression. "Low-Env" cells experienced transient poration and calcein leakage, while "high-Env" cells were killed. The cell-killing effect was confirmed with an independent mitochondrial activity-based cell viability assay, showing dose-dependent cytotoxicity in response to DAVEI treatment. Transfection with increasing quantities of Env DNA showed further shifts toward "High-Env" expression and cytotoxicity, further reinforcing the Env dependence of the observed effect. Controls with unlinked DAVEI components showed no effect on calcein leakage or cell viability, confirming a requirement for covalently linked DAVEI compounds to achieve Env transformation. These data demonstrate that the metastability of Env is an intrinsic property of the transmembrane protein complex and can be perturbed to cause membrane disruption in both virus and cell contexts.
Detection of lung cancer from CT image using image processing and neural network

Field: Computer Science (Physical Sciences)

Detection of lung cancer is the most interesting research area of researcher's in early stages. The proposed system is designed to detect lung cancer in premature stage in two stages. The proposed system consists of many steps such as image acquisition, preprocessing, binarization, thresholding, segmentation, feature extraction, and neural network detection. At first Input lung CT images to the system and then passed through the image preprocessing stage by using some image processing techniques. In first stage, Binarization technique is used to convert binary image and then compare it with threshold value to detect lung cancer. In second stage, segmentation is performed to segment the lung CT image and a strong feature extraction method has been introduced to extract the some important feature of segmented images. Extracted features are used to train the neural network and finally the system is tested any cancerous and noncancerous images. The performance of proposed system shows satisfactory results and proposed method gives 96.67% accuracy.
Demanding supply: Re-envisioning the landlord/tenant relationship for optimized perennial energy crop production

Field: Business, Management and Accounting (Social Sciences)

As the bioenergy industry in the U.S. expands to meet increased demands for transportation fuel under the Renewable Fuel Standard and electrical power under state Renewable Portfolio Standards and the proposed Clean Power Plan, producers of biomass will seek the ability to grow dedicated, high-yielding energy crops of a perennial nature on leased property. Given the large amount of leased farmland in the U.S., the contributions of tenant-farmers will represent a significant, though currently not well understood, segment of the biomass supply chain. Through the use of contracts as governance schemes, landowners and tenants can navigate three key challenges of the bioeconomy: the necessity of long-term access to land coupled with the development of equitable termination clauses; assuaging landowner concerns regarding the potential invasiveness associated with some novel bioenergy crops; and the reclamation of rhizomes as an additional revenue stream associated with perennial biomass production.
Microneurotrophin BNN27 Reduces Astrogliosis and Increases Density of Neurons and Implanted Neural Stem Cell-Derived Cells after Spinal Cord Injury

Field: Neuroscience (Life Sciences)

Microneurotrophins, small-molecule mimetics of endogenous neurotrophins, have demonstrated significant therapeutic effects on various animal models of neurological diseases. Nevertheless, their effects on central nervous system injuries remain unknown. Herein, we evaluate the effects of microneurotrophin BNN27, an NGF analog, in the mouse dorsal column crush spinal cord injury (SCI) model. BNN27 was delivered systemically either by itself or combined with neural stem cell (NSC)-seeded collagen-based scaffold grafts, demonstrated recently to improve locomotion performance in the same SCI model. Data validate the ability of NSC-seeded grafts to enhance locomotion recovery, neuronal cell integration with surrounding tissues, axonal elongation and angiogenesis. Our findings also show that systemic administration of BNN27 significantly reduced astrogliosis and increased neuron density in mice SCI lesion sites at 12 weeks post injury. Furthermore, when BNN27 administration was combined with NSC-seeded PCS grafts, BNN27 increased the density of survived implanted NSC-derived cells, possibly addressing a major challenge of NSC-based SCI treatments. In conclusion, this study provides evidence that small-molecule mimetics of endogenous neurotrophins can contribute to effective combinatorial treatments for SCI, by simultaneously regulating key events of SCI and supporting grafted cell therapies in the lesion site.
di 22 jie guo ji jie he bing hui yi guan yu fei jie he bing hua xue liao fa de tao lun

Field: Medicine (Health Sciences)

第22届国际结核病会议,1973年9月24日至28日在日本东京召开,81个国家的2000多名代表出席了这次会议。会议中有很多关于利福平(RFP)初治与复治效果的报告,其中关于药物的联用方式、药物的间歇疗法以及间歇疗法的副作用等均受到会议参加者的重视。现将会上有关肺结核化学疗法的内容摘译如下。缩短治疗时间结核病化学疗法的初治标准是12个月到24个月,力争将治疗时间缩短为6个月。从经济
ANALISIS PENERAPAN AKAD MUDHARABAH DALAM PRODUK TABUNGAN HAJI DAN UMROH PADA BTN SYARIAH KCPS KUDUS

Field: Business, Management and Accounting (Social Sciences)

Islamic banking in Indonesia has experienced significant growth, driven by increased public awareness, supportive regulations, and product innovations such as hajj and umroh savings. This study analyzes the application of the mudharabah contract in hajj and umroh savings products at BTN Syariah KCPS Kudus, focusing on compliance with sharia principles and economic effectiveness. Employing a qualitative approach through interviews, observations, and documentation, the study finds that the applied mudharabah muthlaqah contract complies with the DSN-MUI Fatwa, with a profit-sharing ratio of 45:55 and fund management through sharia-compliant instruments. However, low customer literacy and lack of transparency in fund management pose significant challenges. Economically, the product supports the growth of third-party funds (from IDR 3.8 billion in 2022 to IDR 4.5 billion in 2023), but the economic benefits for customers are less significant, as their primary motivation is hajj registration rather than profit sharing. The study recommends enhancing sharia education, transparency, and product innovation to optimize sharia compliance and economic benefits.
Influencer marketing in travel and tourism

Field: Business, Management and Accounting (Social Sciences)

Influencer marketing in travel and tourism builds on the importance of word-of-mouth in the travel context. Tourism marketers started working with bloggers early on as blogs quickly became important information sources for travel decision makers and therefore valuable media for marketers. Inkybee describes influencer marketing as involving influencer discovery, influencer outreach, design of influencer campaigns, influencer tracking/measurement and influencer relations. Krasniak lists ongoing brand ambassadorship, product reviews, brand mentions, event coverage, sponsored content and affiliate links as the most important and effective influencer marketing tactics currently used by marketers. In practice, influencer marketing takes many forms beyond getting the influencer to spread a marketing message. Travel marketers have recognized the great potential of message amplification and targeting afforded by travel social media influencers. The promise of travel perks as well as the ability to associate one's personal brand with desirable travel and tourism brands makes travel and tourism an attractive target industry for influencers.
Comparative Analysis between Hydrous Ethanol and Gasoline C Pricing in Brazilian Retail Market

Field: Energy (Physical Sciences)

The global energy landscape is rapidly changing, including the transition to a low carbon economy and the use of liquid biofuel. The production of liquid biofuel has emerged as an alternative to the use of fossil fuels for purposes of energy conservation, carbon emission mitigation and agricultural development. In this article we study the co-movements between hydrous ethanol and gasoline C in the Brazilian retail market. A multi-scale cross correlation analysis was applied to the Average Retail Margin time series of hydrous ethanol for fifteen relevant retail markets in Brazil to analyze the competitiveness of hydrous ethanol towards gasoline C. The empirical results showed a remarkable different behavior between hydrous ethanol and gasoline C, for any time scale, regardless of geographical distance or regional differences.
Isolation and Identification of α-Ketoaldehydes in Calf and Rabbit Livers

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Carbonyl compounds in calf liver stored at 4°C for 5~6 hr after slaughter were investigated, with emphasis on α-ketoaldehydes. After conversion of carbonyls into their 2,4-dinitrophenylhydrazones (2,4-DNPs), they were fractionated by preparative thin-layer chromatography (TLC); at least, twenty-three fractions were separated, among which eighteen fractions contained 2,4-DNPs of α-dicarbonyls. From some of the fractions, crystalline 2,4-DNPs were isolated, and identified by TLC and infrared spectra: pyruvaldehyde, 3-deoxypentosulose, xylosulose, 3-deoxyglucosulose, 2,3-diketogulonic acid or/and dehydroascorbic acid, and formaldehyde were identified, and glucosulose was tentatively identified. The carbonyl pattern, obtained from rabbit liver frozen in liquid nitrogen immediately after slaughter, was also similar as that from calf liver, and further, the amount of each α-ketoaldehydes remained at the almost same level during storage at 4°C for 24 hr. These results indicate that the identified α-ketoaldehydes are constituents or metabolic intermediates in calf and rabbit livers. The formation mechanisms of the carbonyls in tissues are discussed.
A Criterion for the Boundedness of Singular Integrals on Hypersurfaces

Field: Mathematics (Physical Sciences)

This paper gives geometric conditions on a hypersurface in R" so that certain singular integrals on that hypersurface define bounded operators on L2 .These singular integrals include the Cauchy integral operator in the sense of Clifford analysis and in particular the double layer potential.For curves in the plane, this condition is more general than the chord-arc condition but less general than the Ahlfors-David condition.The main tool is the T(b) theorem [DJS].