jimnoneill/paper-to-field-training huggingface dataset:
Analytic Calculation of Radio Emission from Extensive Air Showers subjected to Atmospheric Electric Fields

Field: Physics and Astronomy (Physical Sciences)

We have developed a code that semi-analytically calculates the radio\nfootprint (intensity and polarization) of an extensive air shower subject to\natmospheric electric fields. This can be used to reconstruct the height\ndependence of atmospheric electric field from the measured radio footprint. The\nvarious parameterizations of the spatial extent of the induced currents are\nbased on the results of Monte-Carlo shower simulations. The calculated radio\nfootprints agree well with microscopic CoREAS simulations.\n
FRI148 Adrenal Vein Sampling: Intra-protocol Hormonal Variability

Field: Medicine (Health Sciences)

Abstract Disclosure: C. Lee: None. Z. Salman: None. J. Shields: None. A.F. Turcu: None. Background: Primary aldosteronism (PA) might arise from one or both adrenal glands. Treatment of PA relies on determining the relative contribution of aldosterone from the two adrenal glands. Adrenal vein sampling (AVS) is essential to identifying patients with lateralized PA (LPA), who benefit from surgery. AVS procedure and interpretation protocols differ between centers. Variability in AVS lateralization has been primarily attributed to cosyntropin use and lateralization index (LI) thresholds. However, data on intra-protocol variability are lacking. Methods: We retrospectively reviewed the clinical records of patients with PA who underwent AVS at University of Michigan between January 2015 and December 2022. In our center, AVS is performed both before and after cosyntropin stimulation, and 6 sets of paired adrenal vein and peripheral serum are obtained: 3 at baseline, and 3 between 5-30 min after cosyntropin stimulation. We included patients who had successful adrenal vein catheterization and valid data from 6 time points. A LI≥4 was considered indicative of LPA. We assessed the rates of inconsistent AVS results within baseline and cosyntropin stimulated samples as proportion of sets in which 1/3 LIs provided different subtyping results than the other 2/3. Results: Of 361 patients included, 107 (29.6%) patients had at least one inconsistent LI. Of these, 74 (20%) patients had an inconsistent LI within the basal sets, 45 (12%) within the cosyntropin stimulated sets, and 12 (3.3%) patients had a discrepant result in both baseline and cosyntropin stimulated sets. The highest outlier rates were observed in the first basal sample (30.3%), followed by the third basal sample (21.9%), the first post-cosyntropin sample (16.0%), and the last post-cosyntropin sample (13.5%). Patients with one intra-protocol outlier were younger (mean age 52.2 ± 11.5 vs. 56.2 ± 10.8 years), but there were no sex, race distribution, or BMI differences between the two groups. Conclusions: The intra-procedural AVS data variability is almost twice as high in basal vs. post-cosyntropin stimulation sampling, particularly in the initial set, likely mediated by acute ACTH fluctuations during the procedure. Our results emphasize the importance of obtaining multiple AVS data sets, in order to best inform the decision for or against surgery. Presentation: Friday, June 16, 2023
Polymorphism of human salivary amylase in the Madras city population.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Polymorphism of human salivary amylase has been studied in the Madras city (South India) population using discontinuous polyacrylamide slab gel electrophoresis. Screening of random (n = 307) and family (n = 51) samples has revealed the presence and distribution of common and variant phenotypes of this enzyme. The occurrence of electrophoretic and isoelectric focusing phenotypes is compared with those of other populations.
Effect of Low Temperature Cultivation on the Phytochemical Profile and Bioactivity of Arctic Plants: A Case of Dracocephalum palmatum

Field: Agricultural and Biological Sciences (Life Sciences)

The influence of climatic factors, e.g., low temperature, on the phytochemical composition and bioactivity of the arctic plant Dracocephalum palmatum Steph. ax Willd. (palmate dragonhead), a traditional food and medical herb of Northern Siberia, was investigated. D. palmatum seedlings were grown in a greenhouse experiment at normal (20 °C, NT) and low (1 °C, LT) temperature levels and five groups of components that were lipophilic and hydrophilic in nature were characterized. The analyses indicated that D. palmatum under NT demonstrates high content of photosynthetic pigments, specific fatty acid (FA) profile with domination of saturated FA (53.3%) and the essential oil with trans-pinocamphone as a main component (37.9%). Phenolic compounds were identified using a combination of high performance liquid chromatography with diode array detection and electrospray ionization mass-spectrometric detection (HPLC-DAD-ESI-MS) techniques, as well as free carbohydrates and water soluble polysaccharides. For the first time, it was established that the cold acclimation of D. palmatum seedlings resulted in various changes in physiological and biochemical parameters such as membrane permeability, photosynthetic potential, membrane fluidity, leaf surface secretory function, reactive oxygen species–antioxidant balance, osmoregulator content and cell wall polymers. In brief, results showed that the adaptive strategy of D. palmatum under LT was realized on the accumulation of membrane or surface components with more fluid properties (unsaturated FA and essential oils), antioxidants (phenolic compounds and enzymes), osmoprotectants (free sugars) and cell wall components (polysaccharides). In addition, the occurrence of unusual flavonoids including two new isomeric malonyl esters of eriodictyol-7-O-glucoside was found in LT samples. Data thus obtained allow improving our understanding of ecophysiological mechanisms of cold adaptation of arctic plants.
In vitro all-trans retinoic acid (ATRA) sensitivity and cellular retinoic acid binding protein (CRABP) levels in relapse leukemic cells after remission induction by ATRA in acute promyelocytic leukemia.

Field: Medicine (Health Sciences)

The current treatment of acute promyelocytic leukemia (APL, also called AML3 subtype) is focused on differentiating agents such as the vitamin A derivative all-trans retinoic acid (ATRA). This agent is a novel and very promising therapy for this disease characterized cytogenetically by a translocation t(15;17)(q21;q22) involving the alpha retinoic acid receptor on chromosome 17 and the PML gene on chromosome 15. Clinical trials have demonstrated that ATRA followed by or combined with conventional chemotherapy may be more beneficial than chemotherapy for inducing complete remission. Unfortunately, ATRA as a single agent, does not appear able to maintain patients in remission (median 5 months), and when relapse occurs resistance to a second induction of ATRA therapy is observed in almost all cases. Recently our laboratory investigated whether specific features of the AML3 cells at relapse could explain the in vivo resistance observed. We have demonstrated that AML3 patients' cells (from four patients) at relapse show high levels of CRABP, a cytosolic retinoic acid binding protein and this protein was not detected prior to ATRA therapy. Relapse-AML3 cells (n = 12) showed reduced differentiation induction when compared with 'virgin'-AML3 cells. Results from this study suggest that CRABP could modulate ATRA cellular concentrations reaching the nucleus. This induced ATRA hypercatabolytic state should be monitored during consolidation therapy and at relapse by evaluating CRABP and RA metabolite levels, in order to detect ATRA resistance in patients with AML3.
IMPLIKASI VIRAL MARKETING, DESAIN KEMASAN PRODUK, DAN ADVERTISING TERHADAP BRAND AWARENESS PRODUK TEH PUCUK HARUM

Field: Business, Management and Accounting (Social Sciences)

This study aims to find out about the Implications of Viral Marketing, Product Packaging Design, and Advertising on Brand Awareness of Teh Pucuk Harum Products. The method in this study is quantitative by using the variables Viral Marketing, Product Packaging Design, Advertising, and Brand Awareness. The hypothesis is tested by the F test (simultaneously) and the T test (partially). The population in this study were all users of Teh Pucuk Harum products whose number is unknown in Samarinda City. Sampling from the number of variable indicators was 14 times the maximum number of 10, namely 140 samples. The results of the analysis showed that there was a significant simultaneous influence on the variables Viral Marketing, Product Packaging Design and Advertising on Brand Awareness of Teh Pucuk Harum products, and showed that Viral Marketing had a significant partial effect on Brand Awareness of Teh Pucuk Harum products, Product Packaging Design had a significant partial effect on Brand Awareness of Teh Pucuk Harum products, and Advertising had a significant partial effect on Brand Awareness of Teh Pucuk Harum products.
Berat Badan dan Panjang Badan Lahir Meningkatkan Kejadian Stunting

Field: Health Professions (Health Sciences)

<p><strong><em>Background:</em></strong><em> Stunting is still a public health problem. The prevalence of stunting in Lampung Province ranks sixth in Indonesia (42.6%). Stunting prevalence based on Nutrition Status Monitoring in 2016 in Pesawaran Regency ranks number four (35.1%). Nutrition student data collection results in Cipadang Village, 12 stunting toddlers (34.3%). </em><strong><em>Purpose:</em></strong><em> The study aims to determine the relationship between body weight and birth length with the incidence of stunting in toddlers. <strong>Method</strong></em><strong><em>s</em></strong><strong><em>:</em></strong><em> An analytical cross sectional research design was conducted in Cipadang Village, Gedong Tataan Subdistrict, Pesawaran District in 2018. The population was all children under five in the study area with a total sample of 103 people taken by random sampling technique. Data collection was carried out by interview and observation to obtain data on the research variables analyzed, including the incidence of stunting, birth weight and birth length. Data analysis with univariate and bivariate analysis using chi square test. <strong>Results:</strong> The results showed the prevalence of stunting was 34.9%, LBW 24.3% and low birth length 31.1%. There is a relationship between birth length and birth weight with toddler stunting. <strong>Conclusion:</strong> Birth weight and birth weight are risk factors for increasing stunting. Increased monitoring of toddler growth on a regular basis in the Posyandu and prevention of LBW should be done to prevent</em><em> stunting.</em></p>
Angiography in the Management of Intracranial Mycotic Aneurysms

Field: Medicine (Health Sciences)

Neurologic abnormalities during the course of bacterial endocarditis have been observed in as many as half the cases in some series.1Although mycotic aneurysm is one of the less common neuropathologic lesions in such cases, it is of particular importance because of the potential danger of lethal subarachnoid hemorrhage from this lesion which is often amenable to surgical excision. The present report of three patients with cerebral mycotic aneurysm will emphasize the following: (1) the clinical features and cerebrospinal fluid (CSF) findings that may be produced by a mycotic aneurysm prior to major hemorrhage; (2) the urgency of performing carotid angiography if there are clinical indications that this lesion may be present; and (3) the value of surgical treatment of intracranial mycotic aneurysms in many cases.

Patient Summaries

Patient 1.

—A 52-year-old white man was admitted to the University of California at Los Angeles (UCLA) Hospital on Feb 19,
Large-scale Epidemiological modeling: Scanning for Mosquito-Borne Diseases Spatio-temporal Patterns in Brazil

Field: Medicine (Health Sciences)

The influence of climate on mosquito-borne diseases like dengue and chikungunya is well-established, but comprehensively tracking long-term spatial and temporal trends across large areas has been hindered by fragmented data and limited analysis tools. This study presents an unprecedented analysis, in terms of breadth, estimating the SIR transmission parameters from incidence data in all 5,570 municipalities in Brazil over 14 years (2010-2023) for both dengue and chikungunya. We describe the Episcanner computational pipeline, developed to estimate these parameters, producing a reusable dataset describing all dengue and chikungunya epidemics that have taken place in this period, in Brazil. The analysis reveals new insights into the climate-epidemic nexus: We identify distinct geographical and temporal patterns of arbovirus disease incidence across Brazil, highlighting how climatic factors like temperature and precipitation influence the timing and intensity of dengue and chikungunya epidemics. The innovative Episcanner tool empowers researchers and public health officials to explore these patterns in detail, facilitating targeted interventions and risk assessments. This research offers a new perspective on the long-term dynamics of climate-driven mosquito-borne diseases and their geographical specificities linked to the effects of global temperature fluctuations such as those captured by the ENSO index.
Struggles Over Leadership in the Women's Liberation Movement

Field: Social Sciences (Social Sciences)

The first independent women’s liberation groups began to emerge in the United States in late 1967, inspired by the Civil Right Movement and other great upsurges for freedom around the world. Women came into the Women’s Liberation Movement (WLM) with ideas about leadership formed in groups ranging from hierarchical churches to anarchistic counter-culture hippie communes. Its early leadership came mostly out of political organizations that fell somewhere inbetween: civil rights, peace, free speech and student movements. Many had ties with the New Left, the Old Left or both. Many were in rebellion against what they perceived as oppressive “male” leadership, meaning that they were often left out of the decision-making process, while doing most of the clerical and other support work. This diversity of experience—much of it unpleasant and some of it outright oppressive—made fractiousness over leadership inevitable. This chapter explores some of the theoretical and ideological struggles over leadership in the Women’s Liberation Movement during its heyday—including my own experience, sometimes as follower, sometimes as leader. It will show that when the growth of the movement called forth a need for more structured organizations with accountable leaders, it was met with a resistance that contributed greatly to radical feminism’s inability to unite, fight and survive. My account of the first year of the women’s liberation movement focuses largely on New York Radical Women (NYRW), partly because, as a member, I have first hand knowledge of its history. Also NYRW was one of the hotbeds in which many of the theoretical and strategic questions that marked 1968 were debated and developed, including consciousness-raising, “the personal is political” and “the pro-woman line,” and where much practical independent WLM activity was organized, from the Miss America Pageant Protest to the journal, Notes from the First Year. Other women’s liberation groups went through similar experiences with local variations.
Transcription analysis in Trypanosoma brucei

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Conference Article| October 01 1990 Transcription analysis in Trypanosoma brucei ALBERT W. C. A. CORNELISSEN; ALBERT W. C. A. CORNELISSEN 1Max-Planck-Institut für Biologie, Molecular Parasitology Unit, Spemannstrasse 34, D-7400 Tübingen, F.R.G. Search for other works by this author on: This Site PubMed Google Scholar SILKE BACKES; SILKE BACKES 1Max-Planck-Institut für Biologie, Molecular Parasitology Unit, Spemannstrasse 34, D-7400 Tübingen, F.R.G. Search for other works by this author on: This Site PubMed Google Scholar RAYMOND EVERS; RAYMOND EVERS 1Max-Planck-Institut für Biologie, Molecular Parasitology Unit, Spemannstrasse 34, D-7400 Tübingen, F.R.G. Search for other works by this author on: This Site PubMed Google Scholar ERNST J. M. GRONDAL; ERNST J. M. GRONDAL 1Max-Planck-Institut für Biologie, Molecular Parasitology Unit, Spemannstrasse 34, D-7400 Tübingen, F.R.G. Search for other works by this author on: This Site PubMed Google Scholar WALDEMAR JESS; WALDEMAR JESS 1Max-Planck-Institut für Biologie, Molecular Parasitology Unit, Spemannstrasse 34, D-7400 Tübingen, F.R.G. Search for other works by this author on: This Site PubMed Google Scholar JOSEF KÖCK JOSEF KÖCK 1Max-Planck-Institut für Biologie, Molecular Parasitology Unit, Spemannstrasse 34, D-7400 Tübingen, F.R.G. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: April 26 1990 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1990 Biochemical Society1990 Biochem Soc Trans (1990) 18 (5): 710–714. https://doi.org/10.1042/bst0180710 Article history Received: April 26 1990 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation ALBERT W. C. A. CORNELISSEN, SILKE BACKES, RAYMOND EVERS, ERNST J. M. GRONDAL, WALDEMAR JESS, JOSEF KÖCK; Transcription analysis in Trypanosoma brucei. Biochem Soc Trans 1 October 1990; 18 (5): 710–714. doi: https://doi.org/10.1042/bst0180710 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: RNAP, RNA polymerase, AMA, alphaamanitin, VSG, variant-surface glycoprotein, CTD, C-terminal domain, OP, 1,10-phenanthroline, EDTA, ethylenediaminetetraacetic acid, medRNA, mini-exon derived RNA This content is only available as a PDF. © 1990 Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Cost-Effectiveness of Dengue Vaccination in Indonesia: Considering Integrated Programs with Wolbachia-Infected Mosquitos and Health Education

Field: Medicine (Health Sciences)

Despite the fact that morbidity and mortality rates due to dengue infection in Indonesia are relatively high, a dengue vaccination has not yet been introduced. Next to vaccination, Wolbachia-infected mosquitoes and health education have been considered to be potential interventions to prevent dengue infection in Indonesia. This study was aimed to analyse the cost-effectiveness of dengue vaccination in Indonesia whilst taking Wolbachia and health education programs into account. An age-structured decision tree model was developed to assess the cost-effectiveness. Approximately 4,701,100 children were followed-up in a 10-year time horizon within a 1-year analytical cycle. We compared three vaccination strategies: one focussing on vaccination only, another combining vaccination and a Wolbachia program, and a third scenario combining vaccination and health education. All scenarios were compared with a no-intervention strategy. The result showed that only vaccination would reduce dengue fever (DF), dengue haemorrhagic fever (DHF), and dengue shock syndrome (DSS) by 123,203; 97,140 and 283 cases, respectively. It would save treatment cost at $10.3 million and $6.2 million from the healthcare and payer perspectives, respectively. The combination of vaccination and a Wolbachia program would reduce DF, DHF and DSS by 292,488; 230,541; and 672 cases, respectively. It would also save treatment cost at $24.3 million and $14.6 million from the healthcare and payer perspectives, respectively. The combination of vaccination and health education would reduce DF, DHF, and DSS by 187,986; 148,220; and 432 cases, respectively. It would save treatment cost at $15.6 million and $9.4 million from the healthcare and payer perspectives, respectively. The incremental cost-effectiveness ratios (ICERs) from the healthcare perspective were estimated to be $9995, $4460, and $6399 per quality-adjusted life year (QALY) gained for the respective scenarios. ICERs from the payer perspective were slightly higher. It can be concluded that vaccination combined with a Wolbachia program was confirmed to be the most cost-effective intervention. Dengue infection rate, vaccine efficacy, cost of Wolbachia program, underreporting factor for hospitalization, vaccine price and mortality rate were considered to be the most influential parameters affecting the ICERs.
[Unexpected difficult intubation caused by a laryngeal web].

Field: Medicine (Health Sciences)

We report a case of unexpected difficult intubation in an adult caused by a laryngeal web. A 43-year-old woman with uterine myoma was scheduled for abdominal hysterectomy. After induction of anesthesia, the vocal cords were seen clearly under laryngoscopy. Although intubation was attempted several times, a 6.5 mm internal diameter tracheal tube could not be passed below the level of the vocal cords because of resistance, and we used a laryngeal mask during anesthesia. Next morning after the operation, she developed dyspnea. Bronchoscopy revealed a very narrow airway below the level of vocal cords caused by a laryngeal web. Tracheostomy was performed. Two weeks later, tracheostomy was closed without any sequela.
Glioblastoma: Emerging Treatments and Novel Trial Designs

Field: Medicine (Health Sciences)

Management of glioblastoma is a clinical challenge since very few systemic treatments have shown clinical efficacy in recurrent disease. Thanks to an increased knowledge of the biological and molecular mechanisms related to disease progression and growth, promising novel treatment strategies are emerging. The expanding availability of innovative compounds requires the design of a new generation of clinical trials, testing experimental compounds in a short time and tailoring the sample cohort based on molecular and clinical behaviors. In this review, we focused our attention on the assessment of promising novel treatment approaches, discussing novel trial design and possible future fields of development in this setting.