jimnoneill/paper-to-field-training huggingface dataset:
Patients with hidradenitis suppurativa have no increased risk of Alzheimer disease

Field: Medicine (Health Sciences)

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease and 30-40% of patients report first-degree relatives with HS [1]. Both familial HS and Alzheimer's disease (AD) are linked to mutations in the γ-secretase complex. [2] The γ-secretase complex consists of presenilin (PS), nicastrin (NCSTN), anterior pharynx defective-1 (APH-1), and pesenilin enchancer-2 (PEN-2). The complex cleaves substrates in the lipid bilayer, most notably amyloid precursor protein (APP) and Notch. [3] Amyloid plaques of the brain are a key step in the pathogenesis of AD [3] and amyloidosis has been described in HS patients [4]. Due to causal mutations in the same complex, researchers have speculated if AD and HS are caused by the same mutations or mutually exclusive. [5] We have therefore studied the risk of AD in patients with HS.

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Intermittent hypoxia enhances chemical sensitivity of pulmonary C fibers in rats: role of reactive oxygen species

Field: Neuroscience (Life Sciences)

Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia (IH) during sleep. Clinically, OSA may occur concomitantly with noturnal asthma and cough reflex, it is likely that involves hypersensitivity of pulmonary C fibers (PCFs) during airway inflammation. This study was performed to determine whether the excitabilities of PCFs to chemical and mechanical stimuli are altered by IH‐induced production of reactive oxygen species (ROS). In anesthetized, open‐chest, and artificially ventilated rats, delivered ten episodes (30 s of N 2 + 30 s of 21% O 2 ) of IH into the lungs significantly enhanced phrenic apnea to intravenous injection of capsaicin, a selective stimulant of PCFs. Bilateral vagotomy abolished apneic response to capsaicin both before and after IH. Subsequent recording of single‐fiber activity of PCFs (PCF A ) showed that IH caused a slight increase in baseline PCF A . Additionally, IH markedly enhanced PCF A to capsaicin injection, and this enhanced response lasted for more than 30 min after termination of IH. In contrast, IH did not change the response of PCF A to lung inflation. The potentiating responses of these PCFs to capsaicin after IH were greatly attenuated by pretreatment with dimethylthiourea, a hydroxyl radical scavenger. These results suggest that IH augments the responses of the C‐fiber afferents to capsaicin, and this potentiating effect of IH is mediated through the action of ROS.
Performance at high temperature of alkali-activated slag pastes produced with silica fume and rice husk ash based activators

Field: Materials Science (Physical Sciences)

This study assessed the mechanical properties, and structural changes induced by high temperature exposure, of alkali-silicate activated slag cements produced with sodium silicates derived from silica fume (SF) and rice husk ash (RHA).Similar reaction products were identified, independent of the type of silicate used, but with subtle differences in the composition of the C-S-H gels, leading to different strength losses after elevated temperature exposure.Cements produced with the alternative activators developed higher compressive strengths than those produced with commercial silicate.All samples retained strengths of more than 50 MPa after exposure to 600 °C, however, after exposure to 800 °C only the specimens produced with the RHA-based activator retained measurable strength.This study elucidated that silicate-activated slag binders, either activated with commercial silicate solutions or with sodium silicates based on SF or RHA, are stable up to 600 °C.
Post-surgery perception of subjective contour figures in the cases of the congenitally blind

Field: Neuroscience (Life Sciences)

The present experiment was planned to examine whether or not the congenitally blind after surgery were capable of seeing the subjective contour, when Kanizsa's original and a modified version of it were presented for the first time. Three subjects (M. O., To. M. and K. T.) who have continued a series of experiments for visual learning with us participated in the experimental runs. All subjects have already attained the ability to identify the 2D shape and solids. Initially it was expected that the subject's response could be classified as indicating that the subjective contours were seen or that they were not. However, it was found that (1) at least another two classes of responses should be added, and (2) that the commonly reported phenomenon of subjective contours in the normally sighted was rare in the congenitally blind subjects after surgery. A theoretical implication of the results is briefly discussed.
Influence of Plasma Characteristics on Nitrogen Mixing into Shielding Gas in Helium Gas Tungsten Arc Welding

Field: Engineering (Physical Sciences)

The influences of welding condition on the atmospheric nitrogen mixing into the arc plasma in helium GTA welding was analyzed by numerical simulations. In order to evaluate the effects of the convection flow and the diffusion on the nitrogen mixing phenomenon, the distributions of the Peclet number was used. Elongation of the electrode length has low impact on the decrease of shielding gas concentration because the convection flow becomes dominant in this area which indicates higher Peclet numbers. Meanwhile, the nitrogen diffusion increases in the plasma area with the temperature of about 10,000K, so that elongation of the arc length leads to a remarkable decrease of shielding gas concentration. Additionally, the impact of convection flow increases in the arc center area where high-velocity plasma jet exists, and the shielding gas concentration tends to rise owing to higher welding current in the condition of sufficient shielding gas flow rate.
Socio-demographic and clinical profile of patients attending a mental health camp: A study from Kanchanpur district of western Nepal

Field: Medicine (Health Sciences)

Background: Mental health is an ignored area of general health care system despite the magnitude of problem and financial burden on families and whole country. In our country, psychiatric services are out of reach to majority of population because of inadequate mental health professionals, lack of awareness and lack of proper mental health policy. This study is conducted with the objective to know socio-demographic and diagnostic profile of patients from a mental health check up camp conducted at Belauri, Kanchanpur district from far western region of Nepal. Material and Methods: This is a descriptive study, comprised of all consecutive participants i.e. 128 patients attending Maryknoll mental health check up camp at Belauri town of Kanchanpur district, Nepal. The Study was performed in March 2013. Socio-demographic data and clinical diagnosis based on International Classification of Disease- 10 diagnostic research criteria were collected and analyzed. Results: Out of 128 subjects studied, highest number of participants (35.94%) belonged to age group 21- 30 yrs followed by age group 11-20 yrs (18.75%) and age group 31-40 yrs (16.40%). The most common psychiatric morbidity was found to be Neurotic, stress related & somatoform disorders (23.45%) followed by mood disorder in 24 (18.75%) patients and Headache (Migraine & Tension type) in 18 (14.07%) patients. Conclusion: The commonest age group affected with mental illness is younger age groups and Neurotic, stress related & somatoform disorders are the most common psychiatric morbidity followed by mood disorders. DOI: http://dx.doi.org/10.3126/jpan.v2i2.9724 J Psychiatrists’ Association of Nepal Vol.2, No.2, 2013 35-38
A COMPARISON OF THYMIDYLATE SYNTHETASE ACTIVITIES FROM 5‐FLUORODEOXYURIDINE SENSITIVE AND RESISTANT VARIANTS OF MOUSE NEUROBLASTOMA1

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract— We have previously described a 5‐fluorodeoxyuridine (FUdR) resistant variant of mouse neuroblastoma possessing an 8‐fold elevation in methylenetetrahydrofolate: dUrd‐5′‐P C‐methyltransferase (EC2.1.1.b) [trivial name: thymidylate synthetase] specific activity relative to that of the sensitive parental clone. This increased specific activity is not associated with a change in cytoplasmic inhibitors or activators, a decreased degradation rate of the enzyme, or the synthesis of a new species with an increased V max , but appears to represent an increased synthesis of the enzyme species found in the sensitive parental clone. More resistant cell populations demonstrate even higher specific activities of this enzyme. The enzymatic activities from both the FUdR sensitive and resistant cells have identical stabilities to sonication, freezing, heat, urea, and sodium dodecyl sulfate, are equally and strongly inhibited by 5‐fluorodeoxyuridine‐5′‐phosphate, and have the same affinity for the substrate 2′‐deoxyuridine‐5′‐phosphate ( K m = 1·4 = 10 −6 m ). Both are stimulated by the addition of mercaptans and partially protected from heat denaturation in the presence of substrate. Unlike Don Chinese hamster cells (C onrad & R uddle 1972) an actinomycin d pulse of neuroblastoma cells in monolayer culture did not increase the thymidylate synthetase specific activity. Mixed growth of FUdR sensitive and resistant cells produced only additive activities.
Analysis of the Influence of Accounting Information on Stock Price with the Extent of Corporate Social Resp<b>onsibility Disclosures as a Moderation</b>

Field: Business, Management and Accounting (Social Sciences)

Corporate social responsibility (CSR) is a new dimension because “it opens new work spaces for the accounting discipline and articulates it with transparency, ethics, and the social responsibility of the company towards society as a whole." In this sense, it allows companies to receive only benefits, in social, economic and environmental matters, allowing, through what is reflected in the financial statements, to comply with what is established by the Micro, Small and Medium Enterprises Development Act, 2006 determined by the Ministry of Finance, India, in which it specifies the incentives for MSMEs that are covered by the provisions that it indicates, these being the following incentives: Additional scores in public tenders, Access facilities to credits greater than a certain amount, Access to micro and small business development programs, Promotion of Technological Innovation, and Others that are incorporated in the future by the National Government. In this way, the present study explores compliance with standards, principles, and procedures that regulate the financial, accounting, and tax structure and operation of the company represented by NDR Auto Components Ltd, guiding management to counteract the tax obligations covered by the law. This is why it is intended to argue and document the importance and advances of corporate social responsibility on accounting information, in the use of IFRS, in terms of the management of this new legislation, those that refer to taxes.
Primary Studies on Shikimic Acid from Aniseed Residue by Microbial Transformation

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

A new way to obtain shikimic acid(SA) through microbial transformation of the bacteria Salmonella B31 in aqueous extracting solution of aniseed residue and its affecting factors were studied.HPLC analysis showed that S.B31 did not produce SA itself.Using the S.B31 to transform the extracting solution of aniseed residue,the concentration of SA increased from 8.04 g/L to 8.80 g/L and reached to the highest content between 20 h and 24 h,and then content of SA was decreased during the prolonged culture.The best transformation effect was obtained for the solution of aniseed residue∶water extracts for 1∶40(g∶mL) with the bacteria S.B31 culture for 24 h and the highest SA content was 0.213 g/L,which increased 2.56 times.
Mechanical Properties of Quaternary Blended Geopolymer Concrete

Field: Engineering (Physical Sciences)

Abstract Over the past decade, Geopolymers were considered as a novel promising material for sustainable development in the construction industry. It is a well-known fact that to reduce the usage of OPC concrete, usage of alternative binders is mandatory. Past Literature reveals that Industrial wastes such as Fly ash, GGBS, Metakaolin and Rice husk ash were extensively used in geopolymer concrete in the form of combination of binary, ternary and quaternary blended concretes. However, there is a very little report was reported on binary and Ternary blended geopolymer concrete. The research work on Quaternary blended concrete using Fly ash, GGBS, metakaolin and Wollastonite was not reported so far. Geopolymer concrete is a novel substance involves various chemical compositions and reactions in a binding material. The research work focused upon on the mix design and mechanical characteristics of binary, Ternary and quaternary blended geopolymer concrete. Quaternary blended GPC is made up of four binding components namely Fly Ash, Ground Granulated Blast Furnace Slag, Metakaolin, and Wollastonite. The Binary blended GPC i.e. Fly Ash to GGBS ratio, geopolymer mix was 70:30. The ratios of Fly Ash: GGBS: Metakaolin for the ternary blended mix were 50:30:20& Fly Ash: GGBS: Metakaolin: Wollastonite for the quaternary geopolymer mixtures is 30:30:20:20 respectively. Wollastonite is a calcium metasilicate (CaSiO 3 ) mineral. Sodium, when present in an alkaline solution alongside silicate and hydroxide, triggers the activation of the binding elements. The alkaline promoter (NaOH/Na 2 SiO 3 ) ratio was set at 2.5, while the precise amount of sodium hydroxide (NaOH) had been maintained at 8M(Molarity). The present experimental investigation demonstrates that mechanical properties of GPC such as compressive strength, flexural strength and split tensile strength for Quaternary blended Geopolymer concrete have outperformed the other two blends i.e. binary and ternary blended GPC due to the Wollastonite based quaternary binder.
PERILAKU MASYARAKAT TERHADAP PENYIMPANAN ARSIP KELUARGA

Field: Social Sciences (Social Sciences)

The family is the first organization where a person socializes and gets education. In one family creates an archive of everyone in the family. The archives produced in a family are important documents in the phase of human life, ranging from marriage certificates, birth certificates, family cards, and other documents. Maintenance of archival documents in a family is an important thing that must be done, to maintain the integrity of the documents and information contained therein. In rural communities, the management and maintenance of family records is still very minimal in information, so it is not uncommon for family records to be neglected and lost, due to the lack of awareness of family members to maintain their archives. The focus of the research in this study is to look at how to manage digital-based family records and the factors that influence the management of digital-based family records. The method used in this research is a case study. Data were obtained from surveys and literature studies. The results of this study can be seen that people in Indonesia are not fully aware of backing up data from their family archives to anticipate the risk of loss or damage to archives.
Carbon Dots as Potential Therapeutic Agents for Treating Non-Alcoholic Fatty Liver Disease and Associated Inflammatory Bone Loss

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Nonalcoholic fatty liver disease (NAFLD) has emerged as one of the most significant metabolic diseases worldwide and is associated with heightened systemic inflammation, which has been shown to foster the development of extrahepatic complications. So far, there is no definitive, effective, and safe treatment for NAFLD. Although antidiabetic agents show potential for treating NAFLD, their efficacy is significantly limited by inadequate liver accumulation at safe doses and unwanted side effects. Herein, we demonstrate that pharmacologically active carbon dots (MCDs) derived from metformin can selectively accumulate in the liver and ameliorate NAFLD by activating hepatic PPARα expression while maintaining an excellent biosafety. Interestingly, MCDs can also improve the function of extrahepatic organs and tissues, such as alleviating alveolar inflammatory bone loss, in the process of treating NAFLD. This study proposes a feasible and safe strategy for designing pharmacologically active MCDs to target the liver, which regulates lipid metabolism and systemic inflammation, thereby treating NAFLD and its related extrahepatic complications.
Optimizing compositional images of daguerreotype photographs using post processing methods

Field: Computer Science (Physical Sciences)

Abstract Microfocused X-ray fluorescence imaging was used to examine two 19th century daguerreotypes. The distribution of Hg-bearing nanoparticles beneath the Au gilding layer gives rise to contrast in the photographs. The sum image for Au + Hg M line X-rays is therefore a compositional image that mimics daguerreotype photograph contrast. Because the thickness of the Au and Hg on the surface represents a small fraction of the X-ray activation depth, the resulting sum images are not of high quality and are dominated by Poisson noise. This is true even for long collection times up to multiple days in length. Achieving superior contrast resolution by increasing the duration of data collection further is impractical. In this study, a new image processing technique based upon the Haar-Fisz algorithm and wavelet theory was used to improve the image quality of compositional maps. The digitally processed images show a reduction in noise without a loss of spatial resolution over the length-scale of photographic features. The Haar-Fisz denoising algorithm decreased the contribution of the Poisson noise in compositional images. Multiple resolution analysis improved image quality further. Features within the portraits are uniformly more recognizable in the final processed images relative to the raw X-ray images. Intensity line profiles that traverse midtone, highlight and shadow regions of the daguerreotype reveal that spatial resolution is not degraded by the image processing routines. Improvement in image quality is quantified by comparing the relative variance of the raw and Haar-Fisz processed imagery. The use of a Haar-Fisz denoising transformation, coupled with multiple resolution analysis was found to improve the quality of low count X-ray images without impacting the spatial resolution at the scale of photograph features. The process can be implemented in freely available open-source software with a minimum of programming effort. Such digital post processing routines offset the need for longer acquisition times to achieve improved X-ray fluorescence image quality. Finally, because the Au + Hg map is insensitive to surface imperfections and tarnishing via atmospheric adsorption of sulfur, digitally processed images may be used to reconstruct photograph features in heavily disfigured daguerreotypes.
Wesleyan Ministers

Field: Arts and Humanities (Social Sciences)

Journal Article Wesleyan Ministers Get access Lawrence Phillips Lawrence Phillips 1Walton Rectory, Bridgwater Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CLXVI, Issue jun16, 16 June 1934, Page 424, https://doi.org/10.1093/nq/CLXVI.jun16.424a Published: 16 June 1934
Archaea as a Model System for Molecular Biology and Biotechnology

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Archaea represents the third domain of life, displaying a closer relationship with eukaryotes than bacteria. These microorganisms are valuable model systems for molecular biology and biotechnology. In fact, nowadays, methanogens, halophiles, thermophilic euryarchaeota, and crenarchaeota are the four groups of archaea for which genetic systems have been well established, making them suitable as model systems and allowing for the increasing study of archaeal genes’ functions. Furthermore, thermophiles are used to explore several aspects of archaeal biology, such as stress responses, DNA replication and repair, transcription, translation and its regulation mechanisms, CRISPR systems, and carbon and energy metabolism. Extremophilic archaea also represent a valuable source of new biomolecules for biological and biotechnological applications, and there is growing interest in the development of engineered strains. In this review, we report on some of the most important aspects of the use of archaea as a model system for genetic evolution, the development of genetic tools, and their application for the elucidation of the basal molecular mechanisms in this domain of life. Furthermore, an overview on the discovery of new enzymes of biotechnological interest from archaea thriving in extreme environments is reported.
Quantum Control of BEC in Optical Lattice

Field: Physics and Astronomy (Physical Sciences)

In this paper, it would be worthwhile to consider the theoretical and computational approach of controlling Bose-Einstein Condensates (BEC). In high spatial dimension (2D/3D) case, the BEC system is controlled under external force in trapped optical lattice at low temperature. Finally, our conclusion is in accordance with the results in physics/chemistry realms.
The Impact of Easy Accessibility of Transport to Sports Participation of Youth Participants – An Exploratory Study

Field: Social Sciences (Social Sciences)

Sports popularity and sporting facilities have been growing rapidly in Singapore. In recent years, Singapore invested $1.33 billion dollars as part of a public-private partnership (PPP) scheme to construct the Singapore Sports Hub. The Sports Hub is made accessible to many by heavy subsidizations and government funds. Furthermore, the recent triumph of Joseph Schooling at the Rio Olympics has led to a surge in popularity and interest in sports and has taken Singapore sport to a higher level. His achievements had illustrated the effect of sport as a nation-building tool, cultivated nationalism and motivated more people to excel in sports. However, the level of popularity, interest and participation in sports within Singapore is affected by many factors. One important factor is the significant importance and priority given to traditional education and the pursuit of “professions” over sports. As Singaporeans are generally pragmatic and focuses on academics and career building, sports may become inadequate as a pursuit to secure a promising future. Another important factor influencing the level of popularity, interest and participation in sports is the availability and accessibility of sporting facilities. Critical to this factor is the availability and accessibility of transportation systems (both private and public). The aim of this study is to examine the relationship between accessibility of transportation systems and sports participation of participants. The study uses the opinions recorded by survey to identify correlations between easy accessibility of transportation and sports participation, and then formulate new approaches and strategies to address the findings.
SCLERODERMA OVERLAP SYNDROME: A CASE REPORT

Field: Medicine (Health Sciences)

Overlap syndrome is a condition in which the patient presents with features of two or more diseases.These rheumatic conditions can co-exist in various combinations and are not rare, as myopathy or myositis co-exist in scleroderma in up to3 7% of scleroderma patients. 1 Here we present a case of 49 years old patient of overlap syndrome (Scleroderma (LcSS)/Myositis (Dermatomyositis).
Occurrence Download

Field: Agricultural and Biological Sciences (Life Sciences)

A dataset containing 4768205 species occurrences available in GBIF matching the query: { "and" : [ "Country is China", "Year 2000-2024" ] } The dataset includes 4768205 records from 3180 constituent datasets; see https://api.gbif.org/v1/occurrence/download/0000628-240130105604617/datasets/export for details. Data from some individual datasets included in this download may be licensed under less restrictive terms.