jimnoneill/paper-to-field-training huggingface dataset:
The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Thrombin, the terminal serine protease in the coagulation cascade, is a proinflammatory molecule in vivo and induces endothelial activation in vitro. The cellular signaling mechanisms involved in this function are unknown. The role of the p38 mitogen-activated protein kinase (MAPK) signaling pathway in thrombin-induced chemokine production was studied. Phosphorylation of both p38 MAPK and its substrate, ATF-2, was observed in human umbilical vein endothelial cells (HUVECs) stimulated with thrombin, with a maximum after 5 minutes of stimulation. Using the selective p38 MAPK inhibitor SB203580, there was a significant decrease in thrombin-induced interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) protein production and messenger RNA steady-state levels. In addition, SB203580 decreased IL-8 and MCP-1 production induced by the thrombin receptor-1 agonist peptide (TRAP), suggesting functional links between the thrombin G protein–coupled receptor and the p38 MAPK pathway. Furthermore, endothelial activation in the presence of SB203580 decreased the chemotactic activity of thrombin-stimulated HUVEC supernatant on neutrophils and monocytic cells. In contrast, the p42/p44 MAPK pathway did not appear to be involved in thrombin- or TRAP-induced endothelial chemokine production, because there was no reduction in the presence of the p42/p44-specific inhibitor PD98059. These results demonstrate that the p38 rather than p42/44 MAPK signaling pathway plays an important role in thrombin-induced endothelial proinflammatory activation and suggest that inhibition of p38 MAPK may be an interesting target for anti-inflammatory strategies in vascular diseases combining thrombosis and inflammation.
Low-energy ionization of hydrocarbons in the quadrupole ion trap mass spectrometer

Field: Chemistry (Physical Sciences)

The capabilities of a commercial ion trap mass spectrometer to readily perform chemical ionization experiments have been exploited to account for the restrictions of the instrument to perform low-energy (∼10 eV) electron ionization (EI) experiments. CS2 and benzene have been used as representative reagent compounds for low-energy ionization by charge exchange in the ion trap with the main objective being the production of mass spectra of hydrocarbon compounds with intense peaks in the molecular ion region. n -Pentane was used as a representative small alkane reagent compound to investigate its capability to form intense peaks of molecular ion species in the spectra of saturated hydrocarbons. No intense peaks were produced in the molecular ion region, by any of the three reagents, for the mass spectra of model linear saturated hydrocarbons. The relatively weak stability of these compounds and the excess amounts of internal energy supplied by the various dynamic processes in the ion trap may partly account for the increased fragmentation. Intense molecular ion species and fragment ion peaks were observed in the mass spectra of cyclic saturated hydrocarbons. Charge exchange of aromatic compounds with CS2 and benzene produced mass spectra with intense molecular ion peaks and limited fragmentation, similar to the mass spectra obtained in conventional mass spectrometers. The methods developed in this study were used for the analysis of typical middle distillate and heavy petroleum samples. © 1998 John Wiley & Sons, Ltd.
Temporal coherence

Field: Computer Science (Physical Sciences)

Article Share on Temporal coherence Author: Pascal Gautron France Telecom R&D Rennes, France France Telecom R&D Rennes, FranceView Profile Authors Info & Claims SIGGRAPH '07: ACM SIGGRAPH 2007 coursesAugust 2007 Pages 9–eshttps://doi.org/10.1145/1281500.1281624Online:05 August 2007Publication History 0citation12DownloadsMetricsTotal Citations0Total Downloads12Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Effective contribution of transplanted vascular progenitor cells derived from embryonic stem cells to adult neovascularization in proper differentiation stage

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

We demonstrated that Flk-1+ cells derived from mouse embryonic stem (ES) cells can differentiate into both endothelial cells (ECs) and mural cells (MCs) to suffice as vascular progenitor cells (VPCs). In the present study, we investigated the importance of the stage of ES cell differentiation on effective participation in adult neovascularization. We obtained Flk-1+LacZ-expressing undifferentiated VPCs. Additional culture of these VPCs with vascular endothelial growth factor (VEGF) resulted in a mixture of ECs and MCs (differentiated VPCs). We injected VPCs subcutaneously into tumor-bearing mice. Five days after the injection, whereas undifferentiated VPCs were often detected as nonvascular cells, differentiated VPCs were more specifically incorporated into developing vasculature mainly as ECs. VPC-derived MCs were also detected in vascular walls. Furthermore, transplantation of differentiated VPCs augmented tumor blood flow in nude mice. These results indicate that a specific vascular contribution in adult neovascularization can be achieved by selective transplantation of ES cell–derived VPCs in appropriate differentiation stages, which should be the basis for vascular regeneration schemes.
Wind retrieval of airborne fiber Doppler wind lidar and experimental verification

Field: Physics and Astronomy (Physical Sciences)

Through the analysis of measurement characteristics for a 1 550nm all-fiber airborne doppler wind lidar,the ways of the velocity correction of plane and the exact wind retrieval algorithms were presented,also a software was completed for the derivation and display of the 3- dimension wind field for airborne Doppler lidar.A comparsion experiment between the airborne doppler lidar and sounding balloons was conducted.By the results statistics of 4airborne campaigns,the bias of wind speed and wind direction is below 1.4m/s and 10°respectively, and the correlation coefficients of wind speed and wind direction are all higer than 0.95.The performance of the lidar system and the accuracy of wind retrieval algorithms are validated by the experimental results.
11β1 integrin is important for mesenchymal cell function : elimination of

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The formation and maintenance of tissues in multicellular animals are crucially dependent on cellular interactions with the extracellular matrix (ECM). Two different studies on such interactions are presented herein.Studies on expression of laminins in normal and dystrophic skeletal muscle, clarified a much debated issue regarding discrepancies seen for laminin α1-chain expression between human and mouse tissues. Lack of laminin α1-chain expression was verified in both mouse and human skeletal muscle. Furthermore, the earlier discrepancies seen for laminin α1-chain expression was explained by showing that an antibody-reagent, commonly used in human studies, recognised the laminin α5-chain rather than the laminin α1-chainThe integrin α11-chain (forming α11β1 integrin) is the latest addition to the integrin receptor family, and belongs to the I domain-containing group of integrin α-chains. Previous studies had shown that α11β1 is a collagen receptor. In the present study, the in vitro and in vivo functions of the α11-chain were further characterised. Distribution studies on embryonic human and mouse tissues showed that the α11-chain was expressed on mesenchymal cells in the developing tendon, perichondrium, intervertebral disc, and cornea. The interactions of α11β1 integrin with collagen type I and IV were studied in vitro. The α11β1 bound to these collagens in a manner similar to integrin α2β1 (with collagen type I being the preferred ligand for α11β1). Furthermore, α11β1 was shown to mediate migration on collagen type I coated surfaces, and to mediate contraction of collagen type I gels. The in vivo functions of the α11-chain were investigated by the generation of integrin α11-chain null-mice, using gene targeted disruption of the itga11 in embryonic stem cells. Two independent lines of mice lacking α11 protein were generated. Phenotypic analysis of these mice indicated a role for α11β1 in the formation of the musculoskeletal system.
The share of influence of various factors on the level of milk productivity of cows with different genotypes of CSN3 and DGAT1

Field: Agricultural and Biological Sciences (Life Sciences)

The article is devoted to the study of the degree and reliability of the influence of various factors on milk yield in cows with different genotypes of the kappa-casein and diacetylglycerol O-acetyltransferase genes. The object of the study was black-and-white first-calf heifers, from which venous blood samples were taken and DNA samples were isolated. DNA extraction was performed using the Magnosorb kit (Interlabservice, Moscow) according to the manufacturer's instructions. The CSN3 and DGAT1 genotypes were determined using the PCR-RFLP method. The studies have established that the influence of maternal milk yield (η2 = 24.9%; P < 0.01), service period duration (η2 = 37.3%; P < 0.001) and live weight (η2 = 46.1%; P < 0.001) on milk yield was highest and most significant in first-calf heifers with the CSN3 AB genotype, while these indicators were lower in cows with the CSN3 AA genotype - 24.0% (P < 0.001), 32.6% (P < 0.001) and 6.1%, respectively. The highest and most reliable influence on the milk yield of first-calf heifers with the DGAT1 AA and DGAT1 AK genotype was exerted by the duration of the service period (η2 = 32.4-36.7%; P < 0.001) and live weight (η2 = 11.7-38.1%; P < 0.01-0.001), and such a factor as live weight at the first fruitful insemination has an influence only in heterozygous animals (8.4%; P < 0.05). The milk yield of mothers, the duration of the service period, and live weight have a stronger influence on the level of milk productivity of cows, with a reliable and the largest share of influence noted in heterozygous animals for the CSN3 and DGAT1 genes. At the same time, the duration of the service period had the strongest and most reliable influence on the milk yield of first-calf heifers. High values of the heritability coefficient of milk productivity indicators have also been established in cows that have the B allele of the CSN3 gene and the A allele of the DGAT1 gene in their genotype. Consequently, breeding taking into account the genotypes of marker genes helps to strengthen the heredity of milk productivity in cattle.
Intelligent process-aware information systems to support agility in disaster relief operations: a survey of emerging approaches

Field: Computer Science (Physical Sciences)

Agility is a key characteristic in disaster relief operations. Intelligent process-aware information systems (IPAISs) can support agility in disaster relief operations through providing information and process reach and richness to manage dynamic inter-operations. In this research, based on relevant reference architectures, a conceptual overview of an IPAIS to support agility in disaster relief operations is described. This conceptual overview includes the dynamic partnering, the collaborative process composition, the collaborative ontology management, the global workflow engine, the run-time coordination, the dynamic rule management, the run-time process proposer, and the dynamic interoperability adaptor components. Based on this conceptual overview, a systematic literature review is conducted to explore emerging approaches that can be applied to realise intelligent process-centred collaborative inter-operations to respond disasters. The findings of the conducted review show the applicability of the emerging multi-agent service-oriented modelling and analysis approaches, optimal control theory based methodologies, social network analysis techniques, data-driven inductive methods, resilient-centred approaches for robustness and agility, self-organisation mechanisms based on cyber physical systems and systems of systems perspectives, simulation methods, and trust management procedures to support the realisation of the components of an IPAIS in the context of disaster relief operations.
Infectious agents identified in ticks collected in Umbria Region (Italy)

Field: Veterinary (Health Sciences)

The study covers the monitoring activities, from March to July 2016, in order to assess health conditions of pigeons population and zoonotic risk in the urban environment, as well as organize activities aimed at limiting this Synanthropic species. These data were compared with those provided by IZS UM (Italy) Osservatorio Epidemiologico Veterinario - Epidemiological Veterinary Observatory already published. The tests show that the trend of Salmonella shows a fluctuating situation. Campylobacter coli, Campylobacter jejuni and Salmonella sp, where not found positive in the period, While Campylobacter jejuni shows an analogy with what we have observed for Salmonella. Chlamydia psittaci shows a similar situation to Campylobacter jejuni. The zoonotic potential of this pathogen is confirmed by PCR positivity, observed in the 2016 work. Although the presence of Clamydia and Campylobacter jejuni significantly higher than Salmonella and Campylobacter coli, their common decline from 2007 seems to indicate the urgent need of preventative actions to prevent possible zoonoses. From the very beginning, the parasites, especially Trichomonas and coccidi, are higher than tapeworms (Taenia sp.). Their trend shows a strong increase around 2011, followed by a continuous decline until nowadays, while ascariasis shows to be costant. The surveys carried out from 2003 to 2016 show that proper management of Columba livia in Umbria has reduced the risk of zoonotic diseases transmission. Bacterial and parasitic health hazards are mainly due to the large population of pigeons and the consequent high fecal contamination of the urban environment. Removing the feces is of a primary importance in order to prevent (through vacuum cleaners and fans) the dirt powders enter in apartments, restaurants, offices, hospitals and schools, infecting the environment. The present study also indicates that the urban pigeon may be taken into consideration not only as a possible vector of zoonoses, but also as a strategic bioindicator of environmental pollution
ADAPTIVE ASYMPTOTIC STABILIZATION OF A BIOPROCESS MODEL WITH UNKNOWN KINETICS

Field: Chemical Engineering (Physical Sciences)

Abstract. The stability of a four-dimensional nonlinear model of a wastewater treatment process (proposed by Bernard, Hadj-Sadok, Dochain, Genovesi and Steyer in 2001) is studied. A feedback control law, depending only on on-line measurable quantities, is proposed. This feedback law stabilizes asymptotically the closed-loop system towards a previously chosen operating point. In order to prove that the closed-loop system is asymptotically stable, two Lyapunov-like functions are constructed explicitly. A numerical extremum seeking algorithm is then applied to stabilize the dynamics towards an equilibrium point corresponding to the maximum methane output flow rate. The robustness of the feedback is demonstrated by involving uncertainties in the growth rate model functions. Computer simulations are reported to illustrate the theoretical results. Key words. a model of a wastewater treatment process, adaptive feedback, asymptotic stability, extremum seeking 1.
Analysis of Pre-Service Science Teachers’ Technological Pedagogical Content Knowledge (TPACK) Ability in Online Learning

Field: Social Sciences (Social Sciences)

The development of Information, Communication, and Technology (ICT) impacts Education 5.0 to improve the quality and equity of education services in Indonesia, especially in science learning. This study aims to analyze the ability of pre-service science teachers to use TPACK (Technology Pedagogical Content Knowledge) in online learning. The survey research method is used to get information about TPACK pre-service science teachers' ability to carry out online learning. The sample consisted of 132 pre-service science teachers from education Universities in Indonesia. The research instrument consisted of 42-item questionnaires that assessed TPACK components in online learning. The results showed that the percentage of pre-service science teachers' average score on TPACK ability is 79.87%. The percentage of average scores for each component TPACK is 78.68% for Pedagogical Knowledge (PK), 79.54% for Content Knowledge (CK), 80.73% for Technological Knowledge (TK), 78.94 for Pedagogical Content Knowledge (PCK), 81.73% for Technology Pedagogical Knowledge (TPK), 80.98% for Technology Content Knowledge (TCK), and 78.64% for TPACK. The highest average scores on TPACK are TPK, TCK, and TK. It is concluded that pre-service science teachers' TPACK skills in online learning related to the use of technology are superior to content knowledge and pedagogy.
Application of FTIR-ATR Spectroscopy to Determine the Extent of Lipid Peroxidation in Plasma during Haemodialysis

Field: Medicine (Health Sciences)

During a haemodialysis (HD), because of the contact of blood with the surface of the dialyser, the immune system becomes activated and reactive oxygen species (ROS) are released into plasma. Particularly exposed to the ROS are lipids and proteins contained in plasma, which undergo peroxidation. The main breakdown product of oxidized lipids is the malondialdehyde (MDA). A common method for measuring the concentration of MDA is a thiobarbituric acid reactive substances (TBARS) method. Despite the formation of MDA in plasma during HD, its concentration decreases because it is removed from the blood in the dialyser. Therefore, this research proposes the Fourier Transform Infrared Attenuated Total Reflectance (FTIR-ATR) spectroscopy, which enables determination of primary peroxidation products. We examined the influence of the amount of hydrogen peroxide added to lipid suspension that was earlier extracted from plasma specimen on lipid peroxidation with use of TBARS and FTIR-ATR methods. Linear correlation between these methods was shown. The proposed method was effective during the evaluation of changes in the extent of lipid peroxidation in plasma during a haemodialysis in sheep. A measurement using the FTIR-ATR showed an increase in plasma lipid peroxidation after 15 and 240 minutes of treatment, while the TBARS concentration was respectively lower.
THE UTILIZATION OF GLYCOGEN BY FLIES DURING FLIGHT AND SOME ASPECTS OF THE PHYSIOLOGICAL AGEING OF DROSOPHILA

Field: Agricultural and Biological Sciences (Life Sciences)

The role of glycogen in the flight physiology was studied for two species of flies, Drosophila funebris and Lucilia sericata. Glycogen was determined by microchemical methods. The flight ability was measured stroboscopically in terms of the total number of wing-beats, under standardized conditions, in continuous flights to exhaustion. Glycogen was found to be of primary importance in the physiology of flight. During continuous flight the concentration of this substance gradually decreases in both the entire animal and the thorax. The decrease in glycogen during the first stages of such flights has no marked effects on the intensity of flight, in terms of the frequency of wing-beat. Near the end of continuous flight the concentration of glycogen becomes limiting and wing-beat frequency rapidly decreases until flight ceases before the frequency becomes as low as 100 double-beats per second. Both the flight ability of Drosophila and the concentration of glycogen vary as functions of age. During the first week of adult life the average length of flight increases from 26 minutes on the first day to 110 on the seventh and the total number of wing-beats from 225,000 to more than a million. Simultaneously the glycogen concentration rises from about 2.5 to 6 per cent of the live weight. In animals older than two weeks the flight ability and glycogen concentration decrease rapidly and then more slowly until, by the thirty-third day, the average length of flight is reduced to 19 minutes (170,000 double wing-beats) and the glycogen concentration to about 3.5 per cent of the live weight. This correlation, although not exact, suggests that the physiological ageing of the flight ability results to a large degree from the simultaneous changes in the concentration of glycogen.
Multi-target Tracking Based on Gaussian Mixture Labeled Multi-Bernoulli Filter with Adaptive Gating

Field: Computer Science (Physical Sciences)

In this paper, an adaptive gating technique is applied to labeled multi-Bernoulli filter. In target tracking systems, elliptical gating based on chi-square test is widely used to filter out clutter. However, tracking performance and robustness can be improved by adaptively changing the gate size. To apply adaptive gating to labeled multi-Bernoulli (LMB) filter based on Gaussian mixture, gate size is adjusted by weight of Gaussian mixture. To verify the effect of adaptive gating in LMB filter, simulations for multi-target tracking in cluttered environments are carried out. The simulation results show that the adaptive gating performs similar or better than elliptical gating in terms of OSPA error.
Design Theory for Speed Control Based on Visual Rhythm for Long Stretches of Freeway

Field: Engineering (Physical Sciences)

This paper analyzed the expressive form and the formation principle of driver’s visual rhythm in the process of driving. Combined with the design model for speed control in straight line section, it proposed the design theory for speed control for long stretches of freeway by using the feature of visual rhythm. Using the 3Ds MAX, the video simulating car moving process on the long stretches of freeway was made in which visual rhythm was a key manipulative parameter. The SSES (Stimulation of Subjectively Equal Speed) was the index of this simulation experiment. Seven males and three females took part in the experiments. The demonstration experiment indicated that the design theory based on visual rhythm can ensure participants regularly maintain a high SSES.
An evaluation of color patterns for imaging of warning signals in cockpit displays

Field: Engineering (Physical Sciences)

The quality of information perception in an aircraft cockpit depends on the way of interacting with display units, including modality, interface structure, and external exploitation conditions. The goal of this work is to find a solution that would allow real-time imaging or doubling of audible warning signals through spatial-temporal color coding. Software emulation of the peripheral display was built. The development and pilot evaluation of the method were both performed. Presentation of visual signals in paracentral field is efficient, but their optical and temporal parameters are critical in relation to distraction effect.