jimnoneill/paper-to-field-training huggingface dataset:
Central nervous system relapse after bone marrow transplantation for acute myeloid leukemia

Field: Medicine (Health Sciences)

Central nervous system (CNS) relapse with meningeal leukaemia occurred 6 months after allogeneic bone marrow transplantation (BMT) for acute myeloid leukaemia, without systemic relapse. Despite intrathecal chemotherapy a severe progressive proprioceptive impairment of the lower limbs developed. Autopsy revealed selective ascending tract degeneration of the gracile fasciculi of the posterior columns of the spinal cord and residual endoneurial deposits were found in lumbosacral dorsal nerve roots and ganglia. While CNS relapse may occur in acute leukaemia after chemotherapy, it has rarely been reported following BMT.
Dislocation Etchant for Beryllium Oxide

Field: Materials Science (Physical Sciences)

A hydrochloric acid chemical etchant for BeO was refined and evaluated. The etchant, when used for 20 min at 120°C on chemically polished surfaces, produces distinctive pits at dislocations intersecting the (0001) and (101) surfaces. Correspondence of etch pits and dislocations was inferred by comparing the enlargement of pits with etching time and the constancy of pit density with continued etching. On {1010} surfaces, the etchant is not sensitive to sites of defect emergence and hence leaves a relatively flat, featureless surface. The etch rates and activation energies are given for {0001}, {1010}, and {101} surfaces. The reaction mechanism is discussed.
The Interplay Between Negative Alcohol Expectancies and Locus of Control and Its Association with Motivation to Change Alcohol Use Among Repeat Alcohol-Impaired Drivers

Field: Psychology (Social Sciences)

Alcohol-impaired driving is a costly public health problem with a high rate of recidivism. This investigation aimed to examine the associations among negative alcohol expectancies (NAE), locus of control (LoC), and motivation to reduce alcohol use among repeat alcohol-impaired drivers. Fifty-nine participants with ≥ 2 previous driving under the influence (DUI) arrests were recruited from a correctional treatment facility or the community. Participants completed NAE, LoC, Motivation to Change alcohol use, and psychiatric disorders (e.g., alcohol and/or substance use disorder) assessments. Both proximal (β = −0.37, p = 0.022) and distal (β = −0.40, p = 0.011) NAE were negatively associated with Motivation to Change. External LoC was associated with lower Motivation to Change among repeat alcohol-impaired drivers (β = −0.42, p = 0.006). The association of distal NAE with Motivation to Change was moderated by LoC (β = −0.48, p < 0.002): those with greater internal LoC had greater Motivation to Change when they focused more on distal NAE, whereas those with greater external LoC exhibited weaker Motivation to Change as they perceived more distal NAE. The relationship between NAE and motivation to change among repeat alcohol-impaired drivers can be better explained by considering their association with LoC. Distal NAE can help repeat alcohol-impaired drivers have stronger motivation to change especially when they have greater internal LoC. Treatment programs for repeat alcohol-impaired drivers can be improved when they focus on the enhancement of both internal LoC and the awareness of long-term negative outcomes of alcohol use.
Comparative Transcriptomic Analysis of the Metabolism of Betalains and Flavonoids in Red Amaranth Hypocotyl under Blue Light and Dark Conditions

Field: Agricultural and Biological Sciences (Life Sciences)

Amaranth plants contain abundant betalains and flavonoids. Anthocyanins are important flavonoids; however, they cannot coexist in the same plant with betalains. Blue light influences metabolite synthesis and hypocotyl elongation; accordingly, analyses of its effects on betalain and flavonoid biosynthesis in Amaranthus tricolor may provide insight into the distribution of these plant pigments. We analyzed the betalain and flavonoid content and transcriptome profiles in amaranth hypocotyls under blue light and dark conditions. Furthermore, we analyzed the expression patterns of key genes related to betalains and flavonoids. Amaranth hypocotyls were shorter and redder and showed higher betalain and flavonoid content under blue light than in dark conditions. Key genes involved in the synthesis of betalains and flavonoids were upregulated under blue light. The gene encoding DELLA was also upregulated. These results suggest that blue light favors the synthesis of both betalains and flavonoids via the suppression of bioactive gibberellin and the promotion of DELLA protein accumulation, which also suppresses hypocotyl elongation. The metabolite profiles differed between plants under blue light and dark conditions. These findings improve our understanding of the environmental cues and molecular mechanisms underlying pigment variation in Amaranthus.
Complete mitochondrial genome of Palpita hypohomalia (Lepidoptera: Pyraloidea: Crambidae) and its phylogenetic implications

Field: Agricultural and Biological Sciences (Life Sciences)

The complete mitochondrial genome of a pyraloid species, Palpita hypohomalia, was sequenced and analyzed. This mitochondrial genome is circular, 15,280 bp long, and includes 37 typical metazoan mitochondrial genes (13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes) and an A + T-rich region. Nucleotide composition is highly biased toward A + T nucleotides (81.6%). All 13 protein-coding genes (PCGs) initiate with the canonical start codon ATN, except for cox1 which is CGA. The typical stop codon TAA occurs in most PCGs, while nad2 and cox2 show TAG and an incomplete termination codon T, respectively. All tRNAs have a typical clover-leaf structure, except for trnS1 (AGN) which lacks the dihydrouridine (DHU) arm. Comparative mitochondrial genome analysis showed that the motif "ATGATAA" between atp8 and atp6, and the motif "ATACTAA" between trnS2 and nad1 were commonly present in lepidopteran mitogenomes. Furthermore, the "ATAG" and subsequent poly-T structure, and the A-rich 3' end were conserved in the A + T-rich regions of lepidopteran mitogenomes. Phylogenetic analyses based on our dataset of 37 mitochondrial genes yielded identical topology for the Pyraloidea, and is generally identical with that recovered by a previous study based on multiple nuclear genes. In a previous study of the Crambidae, the Evergestinae was synonymized with Glaphyriinae; the present study is the first to clarify their close relationship with mitogenome data.
Cellular determinants of arrhythmic rysk in hypertrophic cardiomyopathy

Field: Medicine (Health Sciences)

Abstract Background Hypertrophic cardiomyopathy (HCM) is the commonest inherited cardiac disease, with a prevalence of 1/500 in the general population. The most devastating consequence of HCM is sudden cardiac death (SCD) due to ventricular fibrillation, particularly common in children and young adults (age &lt;30 years). The positive correlation between the extent of late gadolinium enhancement (LGE, reflecting myocardial fibrosis) and the arrhythmic risk in HCM suggests that ventricular arrhythmias are held to originate from the fibrotic regions, by a mechanism of electrical re-entry. However, recent data suggest that enhanced cellular automaticity (i.e. early- or delayed-afterdepolarizations, EADs or DADs-), rather than macro-reentry, may be clinically relevant in promoting ventricular arrhythmias in patients. Purpose Aiming to better understand the cellular and molecular mechanisms of arrhythmogenesis in HCM and to establish a reliable arrhythmic risk stratification in patients, we performed a translational study in HCM patients who underwent surgical myectomy, by combining a clinical follow-up study with in vitro assessments of cellular arrhythmogenicity in ventricular cardiomyocytes. Methods We retrospectively studied 61 HCM patients who underwent surgical interventricular-septum myectomy to relieve refractory obstruction-related symptoms. At the time of surgery, fresh ventricular tissue was collected and used to isolate single ventricular cardiomyocytes (CMs), which were used for patch-clamp measurements to assess the occurrence of EADs and DADs. Patients were followed up for a median time of 8 years and the occurrence of non-sustained ventricular tachycardia (NSVT) or life-threatening arrhythmic events (LAE) was monitored. Moreover, data from ECG and contract cardiac magnetic-resonance studies were collected. Results EADs occurred in CMs from 36% of patients and were associated with prolonged action potential duration. DADs occurred in 24% of patients and were associated with abnormalities of CM intracellular Ca2+ handling. The occurrence of NSVT/ LAE in patients was strongly associated with the presence of DADs in cardiomyocytes but not with the presence of EADs. Patients with NSVT/LAE were more likely to show specific “pro-arrhythmic” pathological ECG-patterns. Among patients with LGE, the presence of DADs in cells behaved as a necessary pre-requisite for NSVT/LAE, as none of the patients with evidence of fibrosis who were negative for DADs had arrhythmic events. Conclusions The presence of pro-arrhythmic changes appears to be necessary for arrhythmia generation in HCM and seems to be related with specific alterations at ECG level, that might be used as clinical arrhythmia predictors in HCM patients. Fibrosis per se is not a major predictor of arrhythmias in HCM but may contribute to generate sustained arrhythmias in the presence of substantial cellular triggers (DADs). Funding Acknowledgement Type of funding sources: Public grant(s) – EU funding. Main funding source(s): EU Horizon 2020. Grant number 777204 (silico FCM).
NOX2-dependent immunosuppression in chronic myelomonocytic leukemia

Field: Medicine (Health Sciences)

Abstract Chronic myelomonocytic leukemia (CMML) is a myeloproliferative and myelodysplastic neoplasm with few treatment options and dismal prognosis. The role of natural killer (NK) cells and other antileukemic lymphocytes in CMML is largely unknown. We aimed to provide insight into the mechanisms of immune evasion in CMML with a focus on immunosuppressive reactive oxygen species (ROS) formed by the myeloid cell NADPH oxidase-2 (NOX2). The dominant population of primary human CMML cells was found to express membrane-bound NOX2 and to release ROS, which, in turn, triggered extensive PARP-1–dependent cell death in cocultured NK cells, CD8+ T effector memory cells, and CD8+ T effector cells. Inhibitors of ROS formation and scavengers of extracellular ROS prevented CMML cell-induced lymphocyte death and facilitated NK cell degranulation toward Ab-coated, primary CMML cells. In patients with CMML, elevation of immature cell counts (CD34+) in blood was associated with reduced expression of several NK cell-activating receptors. We propose that CMML cells may use extracellular ROS as a targetable mechanism of immune escape.
Document image binarization using the camera device in mobile phones

Field: Computer Science (Physical Sciences)

This paper proposes an adaptive binarization method for the document image binarization acquired by an imaging phone. The used algorithm determines the local thresholds with the information from the global trend as well as the local details. As a consequence, the proposed method is good not only for preserving the fine details of the character structure, but also for alleviating noise. The effectiveness of the proposed method is illustrated using the results obtained with a Nokia imaging phone.
Using GSP Construction Improving Figure Analysis Ability of Pre-service Elementary Teachers

Field: Social Sciences (Social Sciences)

본 연구에서는 예비 초등 교사의 도형 문제 해결에 있어 필요한 교수 역량을 다양한 문제 해결 능력, 핵심 요소를 추출하는 능력, 그리고 학생의 어려움을 예상하는 능력의 관점에서 그들의 현 실태 파악과 더불어, 교수 역량의 강화 방안으로 GSP 작도를 활용하였다. 그 결과 예비 초등 교사들이 문제 해결에서 오류를 보이기도 하고, 지식에 초점을 둔 핵심 요소를 추출하는 경향이 강하며, 학생들의 어려움을 특정한 한 가지에서 찾는다는 것을 알 수 있었다. 또한 GSP 작도를 통해서 여러 가지 다양한 성질을 부분적으로 탐구하는 것은 가능하나, 통합된 관점에서의 문제 분석 및 개념 간 연결에 어려움을 겪는 것을 발견했다. 더불어 GSP 작도를 통한 시각적 확인 및 탐구 이후, 문제 해결의 방법이 좀 더 다양해졌으며, 학생의 어려움을 예상하는 초점이 다른 방향으로 전환되었음을 확인할 수 있었다. 이러한 결과로부터 GSP 작도가 예비 초등 교사의 교수 역량 강화의 도구로 활용될 수 있도록 돕는 몇 가지 시사점을 추출할 수 있었다. The purpose of the study is to enhance the figure analysis ability for pre-service elementary teacher by using GSP. To do this, we limited to teaching competence divide into ability various problem-solving, extract key elements, predict the difficulty of student and investigated the initial of them, the reality of GSP construction. As results, pre-service elementary teachers made errors, proposed teaching focused on the character using in the problem solving, and found that in one particular difficulties to find the students. The reality of GSP construction activity was possible to explore through the partially constructed a number of various properties, but we found to have difficulty in the connection between concepts. and integrated view of the problem analysis. After visual identification and exploration through the GSP construction, problem-solving ability became a little more variety and changed their direction in order to focus the student's anticipated difficulties. From these results, we could extract some pedagogical implications helping pre-service teachers to reinforce teaching competence by GSP construction.
Factors influencing reproductive performance following previous ectopic pregnancy.

Field: Medicine (Health Sciences)

It seemed as if the probability of repeat ectopic pregnancy increased as the age of the patient increased and the interval between the previous ectopic gestation and new pregnancy is prolonged. At the same time the probability of another ectopic pregnancy decreased as the parity increased. The obstetric outlook following laparotomy for ectopic pregnancy seemed not to be very encouraging as the fertility rate was about 48% and therefore, efforts should be geared at managing patients with ectopic pregnancy laparoscopically. A larger multicenter study is needed to validate these findings.
Of One Mind: The Logic of Hypnosis, The Practice of Therapy

Field: Psychology (Social Sciences)

Jay Haley once said, 'The only reasonable excuse for adding another theory of hypnosis to the many that have been proposed is an entirely new approach to the problem.' In Of One Mind, Douglas Flemons demonstrates that he has an eminently reasonable excuse.\nWith the casual grace of an entrancing storyteller and the dry humor of an experienced therapist and teacher, he recasts the theory of hypnosis within a relational understanding of language, self, and mind. He then transports his ideas to the worlds of hypno-and brief therapies, offering fresh insights about how to connect with clients and help them change.
I. P. Pavlov

Field: Neuroscience (Life Sciences)

IVAN Petrovich Pavlov (Fig 1) was born on Sept 27, 1849, in the old Russian town of Ryazan. His early education was in preparation for a career as a priest. In 1864 he finished the theological school and entered a seminary. However, his refusal to accept religious dogmas and his keen interest in materialistic ideas prompted him to leave the seminary. In 1870 Pavlov enrolled at the natural sciences division of the Physics and Mathematics Department of the St. Petersburg University, where he specialized in animal physiology under the guidance of the well-known Russian scientist I. Tzion. In 1874, Pavlov finished the St. Petersburg University with honors—he was awarded a gold medal. However, he did not regard his education as complete and continued his studies at the Medical Surgical Academy, which he finished in 1879. Shortly afterwards, Pavlov headed the Physiology Laboratory at the clinic of the outstanding Russian internist
Effect of Organization Culture and Organization Commitment on Employee Performance with Organizational Citizenship Behavior as Mediation (Study at Kanwil Direktorat Jendral Pajak Jawa Tengah I In Environment Gedung Keuangan Negara)

Field: Business, Management and Accounting (Social Sciences)

Success of the organization to achieve goals and objectives is largely determined by employee performance. Employee performance is a real behavior that each employee displays as a work performance generated in accordance with its role in the company. Many factors can affect employee performance, such as organizational culture, organizational commitment and organizatonal citizenship behavior. Object of this research is Kantor Wilayah Direktorat Jenderal Pajak (DJP) of Central Java I, Jl. Imam Bonjol No. 1D, Gedung Keuangan Negara Semarang. Based on the data, the average target of tax revenue charged by the employees of Kantor Wilayah DJP Central Java I year 2013 – 2015 amounted to 93,33% with a tendency in three years decreased. The decline in the achievement of these targets is caused by several factors, one of which many employees come late. Employee delay shows that employee performance tends to be low. The purpose of this study is to analyze the influence of organizational culture and organizational commitment on organizatonal citizenship behavior and influence organizatonal citizenship behavior on employee performance. Population of this research are employees of Kantor Wilayah Direktorat Jenderal Pajak (DJP) of Central Java I, Jl. Imam Bonjol No. 1D, Gedung Keuangan Negara Semarang totaling 133 employees. The sample in this research is 57 employees. The data type is primary. Methods of data collection using questionnaires. Analysis technique used is path analysis with previously tested by instrument test and classical assumption test. Result of analysis by using path analysis showed that: 1). Organizational culture effect positive and significant on organizational citizenship behavior (t-test result = 4,700 with sig. 0,000 < 0,05). 2). Organizational commitment effect positive and significant on organizational citizenship behavior (t-test result = 3,709 with sig. 0,000 < 0,05). 3). Organizational citizenship behavior effect positive and significant on employee performance (t-test result = 5,352 with sig. 0,000 < 0,05). 4). Organizational culture proved effect on influence employee performance with organizational citizenship behavior as mediation. 5). Organizational commitment proved effect on influence employee performance with organizational citizenship behavior as mediation Keywords : Organizational Culture, Organizational Commitment, Organizatonal Citizenship Behavior, Employee Performance
Inhibition of Leaf Processes by p-Fluorophenylalanine During Induction of Flowering in the Cocklebur

Field: Agricultural and Biological Sciences (Life Sciences)

The amino acid antimetabolite, DL-p-fluorophenylalanine (FPA), inhibited induction of flowering in the short-day cocklebur plant, Xanthium pensylvanicum Wall., primarily by interfering with processes occurring during the inductive dark period. At the concentrations used the inhibitor had little effect on subsequent vegetative development of the plant.The inhibition was largely reversed (internally) by L-phenylalanine, but not by D-phenylalanine nor by DL-tyrosine. The FPA strongly inhibited the absorption of labeled phenylalanine, leucine, and glycine, and inhibited the conversion of phenylalanine into protein in experiments where incorporation was separated in time from effects upon absorption. The FPA, too, was incorporated into protein, at nearly half the rate of phenylalanine. Neither D- nor L-phenylalanine significantly interfered with absorption of FPA, showing the FPA did not affect amino acid absorption by simple competition for a common carrier site. It was concluded that FPA may affect flower induction because of its interference with normal enzyme synthesis, although effects on other processes might also be involved.
Ne/nápadné proměny vnitřního města v postsocialistickém období. Sociologický a etnologický výzkum v Brně

Field: Social Sciences (Social Sciences)

The paper deals with under researched urban issues in thr Czech Republic. It is particularly devoted to the inner cities, the changes occurring there during the post-socialist transition but also to some continuous and persistent patterns. Through examining the demografic, ethnic and property structures of the inner city of Brno, we shed light on some of the processes which have been occuring here during post-socialism and which should be the focus of further research.
Report on Owned Dog Population Survey In Lingayen, Philippines

Field: Health Professions (Health Sciences)

The Philippines is among the Southeast Asian countries that has a long-standing problem with rabies. About 200 people die of rabies each year in the Philippines, and most are attributed to dog bite cases (Deray, 2015). The sources of infection of more than 95% of human rabies cases worldwide have been reported to be domestic dogs (Cleaveland, et al., 2006). Focusing on the main source rather than the human population, is therefore, the best strategy to eliminate rabies. The World Health Organization (WHO) recommends covering at least 70% of the existing domestic dog population with rabies vaccination in the shortest time possible (WHO, 2015). Experts and epidemiologists also recommend maintaining the population immunity above this critical level for at least twelve months, which also interrupts the transmission of rabies among the target population (Coleman & Dye, 1996; Cleaveland, et al., 2003; Hampson, et al., 2009; Morters, et al., 2013).
ISSUES OF IMPROVEMENT OF THE INSTITUTION OF ADVOCACY IN CRIMINAL PROCEEDINGS

Field: Social Sciences (Social Sciences)

In this article, suggestions were made regarding the issues of improving the legal profession, providing legal services by lawyers, and adding a new clause to the points where the participation of a lawyer is mandatory. It was also recommended that we move to the digitization of criminal proceedings at every stage, and that lawyers in our country continuously expand the use of electronic technologies in their activities. Also, the experience of some foreign countries was studied and many discussions were held. Recommendations were also made regarding the development of new legal bases of electronic criminal proceedings.
Neutral and anionic 2-methyl-6-nitrophenyl palladium(II) complexes. The X-ray crystal structure of bis(benzyltriphenylphosphonium)trans-di-µ-chloro-bis[chloro(2-methyl-6-nitrophenyl)palladate(II)]–acetone (1/2)

Field: Chemistry (Physical Sciences)

By reacting HgR2(R = C6H3Me-2,NO2-6) with [PPh3(CH2Ph)]2[Pd2Cl4(µ-Cl)2](2 : 1) in refluxing acetone the complex trans-[PPh3(CH2Ph)]2[Pd2Cl2(µ-Cl)2R2]·2Me2CO (1) crystallizes in high yield. The anion is a centrosymmetric dimer with both palladium atoms having square-planar co-ordination. The mutually trans chloro ligpnds, one terminal and the other bridging, have similar Pd–Cl bond lengths [2.322(4) and 2.334(4)Å, respectively], both being shorter than the other Pd–Cl bonds [2.448(4)Å] corresponding to the bridging chloro ligands trans to the phenyl groups. The angles between the phenyl rings and the 'PdCl2(µ-Cl)2' moiety plane or their own nitro group planes are 73.3 or 140.2°, respectively. The shortest Pd–O distance [2.893(6)Å] is too long to assume intramolecular bonds. This complex is the first aryl palladium derivative of such a stoicheiometry described so far. From its solutions in dimethyl sulphoxide (dmso) the complex [PdCl2(R)(dmso)]– can be isolated. Complex (1) also reacts with PPh3(1 : 4) or bidentate ligands (1 : 2) to form trans-[PdCl(R)(PPh3)2] or cis-[PdCl(R)(L–L)](L–L = 2,2′-bipyridine or 1,10-phenanthroline) respectively.