jimnoneill/paper-to-field-training huggingface dataset:
SIMPLE AND FAST RP-HPLC METHOD FOR THE DETERMINATION OF PREDNISOLONE SODIUM PHOSPHATE, PREDNISOLONE, ATROPINE, AND HOMATROPINE AS RESIDUALS IN CLEANING VALIDATION OF INDUSTRIAL PHARMACEUTICAL EQUIPMENT

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Determining traces of pharmaceuticals in equipment is an important step for controlling cross-contamination during the production cycle. Time-consuming analysis is not applicable because it of incremental costs, especially in evaluating residuals as steroids and alkaloids that require a fast and specific technique. Here, an isocratic reversed-phase HPLC method was developed for the trace analysis of Prednisolone Sodium Phosphate (PSP), Homatropine (HOM), Atropine (ATR), and Prednisolone (PRE) in cleaning samples from pharmaceutical equipment. For this, a mobile phase mixture of 35/65 (V/V) acetonitrile/potassium dibasic phosphate 10 m mol L−1, pH 6.9 at 1.0 mL min−1, with a phenyl-hexyl column, were used. These parameters enabled quantifying the analytes within 7.0 min, detecting ATR and HOM at 210 nm, while PSP and PRE were monitored at 240 nm, being lineal between 1–100 µg mL−1 in all cases. The quantification and detection limits were 0.04 and 0.02 µg mL−1 for PSP, ATR, and HOM and 0.02 and 0.01 µg mL−1 for PRE. The method proved its worth and specificity even in presence of other formulation components of the final dosage forms without extraction or concentration procedures.
Aldehyde Decarbonylases: Enigmatic Enzymes of Hydrocarbon Biosynthesis

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTAldehyde Decarbonylases: Enigmatic Enzymes of Hydrocarbon BiosynthesisE. Neil G. Marsh*†‡ and Matthew W. Waugh†‡View Author Information† ‡ †Department of Chemistry and ‡Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, United States*E-mail: [email protected]. Phone: (734) 763-6096. Fax: (734) 615-3790.Cite this: ACS Catal. 2013, 3, 11, 2515–2521Publication Date (Web):September 18, 2013Publication History Received1 August 2013Published online10 October 2013Published inissue 1 November 2013https://pubs.acs.org/doi/10.1021/cs400637thttps://doi.org/10.1021/cs400637teditorialACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views4188Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (1 MB) Get e-AlertscloseSUBJECTS:Aldehydes,Hydrocarbons,Oxides,Oxygen,Peptides and proteins Get e-Alerts
Integrated Access and Backhaul via LEO Satellites with Inter-Satellite Links

Field: Computer Science (Physical Sciences)

The third generation partnership project (3GPP) has recently defined two frequency bands for direct access with satellites, which is a concrete step toward realizing the anticipated space-air-ground integrated networks. In addition, given the rapid increase in the numbers of satellites orbiting the Earth and emerging satellites applications, non-terrestrial networks (NTNs) might soon need to operate with integrated access and backhaul (IAB), which has been standardized for terrestrial networks to enable low-cost, flexible and scalable network densification. Therefore, this work investigates the performance of satellite IAB, where the same spectrum resources at a low earth orbit (LEO) satellite are utilized to provide access to a handheld user (UE) and backhaul via inter-satellite links. The UE is assumed to operate with frequency division duplex (FDD) as specified by the 3GPP, while both FDD and time division duplex (TDD) are investigated for backhauling. Our analysis demonstrate that the interference between access and backhaul links can significantly affect the performance under TDD backhauling, especially when the access link comes with a high quality-of-service demands.
Precision and bias of carbon storage estimations in wetland and mangrove sediments

Field: Environmental Science (Physical Sciences)

Peaty sediments in coastal wetlands play an important role in the sequestration of atmospheric carbon dioxide and its belowground storage. Sediment cores are used to quantify organic matter (OM) density, estimated by multiplying the bulk density of a core segment by its OM fraction. This method can be imprecise, as repeated samples often differ widely. Recent studies have shown that sediment bulk density and OM fraction are not independent but tightly related by a function called the ideal-mixing model. Thus, the bulk density of the sediment can be directly estimated from its OM fraction. Statistical theory and simulations demonstrate that the high variance in the product estimation of OM density is the result of error propagation in the product of two functionally related variables with independent errors. Estimating OM density in wetland sediments using the ideal-mixing model is more precise than the traditionally used product estimate, especially in highly organic sediments.
The 2019 guidelines from the American Society for Apheresis: what's new?

Field: Medicine (Health Sciences)

Purpose of review For over 30 years, the American Society for Apheresis (ASFA) has published practice guidelines on the use of therapeutic apheresis in the Journal of Clinical Apheresis (JCA) Special Issue. These guidelines are periodically reviewed with the addition of new indications, retirement of some former indications and the provision of updated recommendations for current indications based on new published literature. During the last 12 years, updated guidelines have been published every 3 years to provide a reflection of current evidence-based apheresis practice. Recently, the eighth special issue was published. Significant updates and changes to the last edition are discussed in this review. Recent findings This review provides a description of the development of the eighth special issue with the evolution of the ASFA guidelines since introduced in 1986. There are no new indications for therapeutic apheresis listed in the 2019 edition, however, several recommended category changes to existing indications have been made. There are also several organizational changes with the renaming of some fact sheets. Summary ASFA has recently published its latest guidelines for therapeutic apheresis in the Journal of Clinical Apheresis ‘Eighth Special Edition’. This review describes the evolution of the ASFA guidelines and highlights significant changes to the prior edition.
Inhibitor development after switching of FVIII concentrate in multitransfused patients with severe haemophilia A

Field: Medicine (Health Sciences)

Summary Switching between different therapeutic FVIII concentrate types has been postulated as a possible cause of inhibitor development in patient with haemophilia A. In this single‐centre, retrospective study, the incidence, titre and duration of inhibitor development in multitransfused patients, defined as patients with more than 150 exposure days ( ED ), were analysed from January 1970 to December 2007 in relation to ED and the number of switches between different products. Inhibitor titre was assessed by Bethesda assay (before 1998) or Nijmegen assay (after 1998). Medical records of 167 patients were screened, of which 97 patients met the inclusion criteria. Fourteen products of plasmatic origin (different purities) and five recombinant (three generations) were used. Nine patients (9%) developed inhibitors, all transient, low‐titre (1.41 ± 0.54 BU) after 323 ± 287 ED in average. Seventeen patients had no product switches of which four patients (23%) developed inhibitors (97 ED in average), whereas 13 patients (77%) did not ( ED : 230). Fifty patients switched between plasmatic products only (median: 10 changes) of which five patients (10%) developed inhibitors ( ED : 503), whereas 45 patients did not ( ED : 932). Five patients switched between recombinant products only (seven changes) of which no patient developed inhibitors (748 ED ). Twenty‐five patients switched between plasmatic and recombinant products (13 changes) of which no patient developed inhibitors ( ED : 1654). No statistically significant differences between patient groups were observed. Neither the number of different FVIII products administered nor the switching of products influenced the incidence of inhibitor in multitransfused patients.
Microbiological profile in Serra ewes' cheese during ripening

Field: Immunology and Microbiology (Life Sciences)

The microflora of Serra cheese was monitored during a 35 d ripening period at three different periods within the ewe's lactation season. After 7 d ripening, the numbers of micro‐organisms reached their maximum, and lactic acid bacteria (LAB) and coliforms were the predominant groups. Pseudomonads were not detected after 1 week of ripening. At all stages of ripening, cheeses manufactured in spring exhibited the lowest numbers of LAB and yeasts, whereas cheeses manufactured in winter showed the lowest numbers of coliforms and staphylococci. Leuconostoc lactis was the most abundant LAB found in Serra cheese whereas Enterococcus faecium and Lactococcus lactis spp. lactis exhibited the highest decrease in percentage composition. Numbers of both Leuc. mesenteroides and Lactobacillus paracasei tended to increase throughout ripening. The most abundant coliform was Hafnia alvei. Klebsiella oxytoca was found in curd but declined in number during ripening. Staphylococcal flora of curd was mainly composed of Staphylococcus xylosus, Staph. aureus and Staph. epidermidis. Staphylococcus xylosus was the major species found at the end of ripening. Pseudomonas fluorescens , was the only Pseudomonas species isolated from the curd. Although a broad spectrum of yeasts were found in Serra cheese, Sporobolomyces roseus was the most abundant yeast isolated.
Back to the UFO

Field: Arts and Humanities (Social Sciences)

were expected to break new boundaries with their touring spectacles, at least in terms of scale.This time they chose to look back to their roots.Only few bands have had such a long and unexpectedly interesting career and history as Pink Floyd.They started pretty much simultaneously with the English version of hippie movement, in 1965, and became the house band of the 'Swinging London' by 1967.Their performances at the time, UFO-club, 24 Hour Technicolour Dream in Alexandra Palace, Albert Hall, and Queen Elizabeth Hall, to mention a few, have become legendary for their syntaesthetic quality, mixing music and psychedelic lighting in an innovative and era-defining way.Psychedelic experience was a combination of music, lights, other artistic visuals and, sometimes, effects of hallucinogenic drugs. 2 Psychedelia can also be seen as an art movement that associates wildly, mixing surrealist heritage, childlikevery much purposefulnaivety, and countercultural activity.With psychedelic aesthetics I, then, refer to the usage of audiovisual technologies that have been utilized to produce the artistic experiences in this vein. 1990s and The Division Bell (1994)Roughly 30 years after touring in a van there was a notable look back to the audio-visual qualities of the sixties Pink Floyd.The seminal release of the post Roger Waters line-up of the band was The Division Bell (1994).The record was themed around communication, and the name was the idea -picked from the lyrics of 'High Hopes'of satirical science fiction author Douglas Adams.Division Bell is located in British Parliament and used to summon the members for votes. 3 The record was followed
PENERAPAN MODEL UTAUT UNTUK MEMAHAMI NIAT MENGGUNAKAN SEARCH ENGINE ADVERTISING PADA PELAKU UMKM PROVINSI BALI

Field: Business, Management and Accounting (Social Sciences)

The purpose of this study was to examine the effect of performance expectancy, effort expectancy and social factor on intention to use search engine advertising. This research was conducted on UMKM in Bali province. Questionnaires became a means of collecting data in this study. The study sample was 75 respondents. The data processing technique in this study is Multiple Linier Regression (MLR). Based on the results of data processing it is known that performance expectancy has a significant positive effect on intention to use search engine advertising. Effort expectancy has no influence on intention to use search engine advertising. Social factor has a significant positive effect on intention to use search engine advertising. Keywords: performance expectancy, effort expectancy and social factor.
Restructurations de la protection sociale et mutations du cycle de vie en Europe

Field: Social Sciences (Social Sciences)

ABSTRACT The move towards early retirement as witnessed over the last few years in Europe comes from social assistance mechanisms, other than old age security and is not due to a simple earlier retirement age. Two systems have been used primarily to help older workers. These are disability and employment insurance. “Early retirement” mechanisms have also helped these active or unemployed workers retire, by means of allocating resources. The social security structure in European countries has remained essentially unchanged with the risks and logistics of management inextricably intertwined. Moreover, these new forms of transition between activity and retirement reveal the reorganization underway in all matters related to the aging workers. One of the implications of the massive movement towards early retirement has been that the tripartite life course in which important social stages within the life course are marked by milestones (e.g., school age, retirement age …) is disappearing. It is gradually being replaced with new flexibility for managing the end of the life course. This type of evolution requires us to rethink the social assistance system in the sense of reducing the distinct ternary division in the life course. From this perspective, the very concepts of retirement and social transfers for definitive inactivity are no longer relevant.
Differential diagnosis of ulcerative colitis with increased diarrhea; collagenous colitis or irritable bowel syndrome? A case report

Field: Medicine (Health Sciences)

A 50-year-old man with a 20-year history of left-sided ulcerative colitis (UC) presented to our hospital with sudden onset of watery diarrhea. To this point, he had been treated with mesalazine 2.0 g/day for UC and had maintained remission. We considered that the UC had worsened. We immediately performed surveillance colonoscopy, which revealed a normal mucous membrane. The results of blood laboratory examinations were normal. Histopathology of colonic biopsies revealed new-onset collagenous colitis (CC), with a thickened subepithelial collagen band (SECB) and inactive UC. We herein report the importance of random colonic biopsies to diagnose CC even when the endoscopic appearance of the colon is normal in patients with inflammatory bowel disease with worsened diarrhea.
GATS and the Social Regulation of Services

Field: Social Sciences (Social Sciences)

Many service transactions are highly complex, and their quality is difficult to ascertain for consumers. In order to have properly functioning service markets, the services thus often require regulation. However, with the advent of the WTO, international trade in services has become increasingly rule-bound. GATS has considerable, intricate effects on social regulation due to the characteristics of services. The allocation of regulatory jurisdiction between home and host country, for example, is rendered difficult by the process-based nature of a lot of services. The WTO US – Gambling dispute settlement report is the first to address GATS disciplines on social regulation in a detailed manner. This working paper submits that the US Gambling report has increased interference with domestic social regulation and created regulatory uncertainty for WTO members. However, it is also argued that the real impact of the GATS on social regulation can only be understood by looking beyond the text of the GATS. GATS disciplines may become amplified through their interaction with domestic and other international law. The GATS also contains some “political” counterbalancing mechanisms that allow members to renegotiate their commitments. It is argued that these political mechanisms strengthen subsidiarity in the GATS, and make WTO dispute settlement bodies accountable to WTO members.
Power Plant Vibration Monitoring and Optimization Using Functional Design of Experiments

Field: Engineering (Physical Sciences)

In a typical pressurized water reactor nuclear power plant, the condensate pumps contribute to the majority of the feedwater flow to the steam generators, which is converted into steam that spins the turbine generator to produce electricity. Adequate monitoring of the condensate pump feedwater flow is essential not only for the pump’s reliability but also for efficient plant operations overall. This study applies the functional principal component analysis in characterizing the vibration signals generated under six different levels of flow rates of the pump, an environmental factor. The functional design of experiments is then applied to obtain an optimal flow rate according to the target vibration curve. The obtained flow rate is found comparable to the theoretical pump curve’s best efficiency point and is recommended to be used for optimal pump performance and reliability.
Femtosecond Laser‐Induced Nanostructured Sacrificial Layer for Stable Zinc Metal Anode

Field: Materials Science (Physical Sciences)

Abstract Aqueous zinc‐ion batteries are a promising option for grid‐scale energy storage owing to their cost‐effectiveness and safety. The Zn metal anode with large gravimetric capacity and moderate redox potential can enable high‐energy‐density Zn batteries. However, the surface instability of commercial Zn metal foils leads to capacity degradation and limited cycle life of batteries. Here, a sacrificial layer strategy is proposed to address these issues by femtosecond laser‐induced nanostructuring on the Zn metal substrate (Fs‐Zn). This sacrificial layer features an orderly interface consisting of exposed aligned crystal edges after the initial stripping process. This structure induces nearly (101)‐oriented epitaxial growth and offers more active sites during the Zn plating/stripping process, effectively minimizing dendrite growth and side reactions. Accordingly, compared with commercial Zn metal, the Fs‐Zn symmetric cell shows prolonged operational life, operating for over 500 h at 1 mA cm −2 /1 mA h cm −2 and 180 h at 0.5 mA cm −2 /1.5 mA h cm −2 . Moreover, the Fs‐Zn||MnO 2 full cell exhibits enhanced cycling stability over 500 cycles. This femtosecond laser‐induced sacrificial layer strategy offers an effective solution to the practical application of aqueous zinc‐ion batteries.
The Influence Of Good Governance Andtransformational Leadership Styles On The Performance Of Local Governments

Field: Business, Management and Accounting (Social Sciences)

This study aims to determine the effect of good governance (X1), transformational leadership style (X2), simultaneously or partially on the performance of officials in the government of North Gorontalo District. As well as the influence of Good governance (X1) on transformational leadership style (X2), the population in this study were State Civil Servants who held structural positions in seven Regional Work Units (SKPD) in the Regional Government of Gorontalo Utara Regency, amounting to 63 people, data collection principal through a list of questions that were tested on the instrument, namely the validity test and reliability test for each question item contained in the list of questions. The analytical method used is the Structural Equation Model PLS by using the Smart PLS.3.0 application. The results showed that, Good governance (X1), has a positive and significant effect on the performance of the apparatus in the North Gorontalo District government. The effect is low with the magnitude of the effect of 0.333 or 33.3%. The transformational leadership style (X2) has a significant and positive effect on the performance of the apparatus in the North Gorontalo district government. The effect is moderate with a large influence of 0.467 or 46.7%. The results showed that, Good governance (X1), has a positive and significant effect on transformational leadership style (X2) in the government of North Gorontalo District. The influence is high, with the magnitude of the effect of 0.712 or 71.2%. Good governance (X1) and transformational leadership style (X2) simultaneously have a positive and significant effect on the performance of the apparatus (Y) in the government of North Gorontalo District. The effect is moderate with the magnitude of the effect of 0.665 or 66.5%.
Metallicity Distribution in the LMC and the SMC Based on the Tip-RGB Colors

Field: Physics and Astronomy (Physical Sciences)

Abstract The color index ( J − K ) 0 of tip-red-giant branch (TRGB) is used to study the metallicity distribution in the Large and Small Magellanic Cloud. With the most complete and pure sample of red member stars so far, the areas are divided into 154 and 70 bins for the LMC and SMC, respectively, with similar number of stars by the Voronoi binning. For each bin, the position of TRGB on the near-infrared color–magnitude diagram, specifically ( J − K ) 0 / K 0 , is determined by the poison-noise weighted method. Converting the color index of TRGB into metallicity, the metallicity gradients in the LMC and the SMC are obtained in four major directions. For the LMC, the gradient to the north is −0.006 ± 0.004 dex kpc −1 , to the south −0.010 ± 0.005 dex kpc −1 , to the east −0.006 ± 0.003 dex kpc −1 , and to the west −0.010 ± 0.003 dex kpc −1 . The farthest distance extends to 16 kpc. For the SMC, the gradients to the north, south, east, and west are −0.017 ± 0.031 dex kpc −1 , −0.016 ± 0.007 dex kpc −1 , −0.003 ± 0.002 dex kpc −1 , and −0.004 ± 0.003 dex kpc −1 , respectively. The farthest distance for the SMC extends to 27 kpc. The gradient is large from the center to 1 kpc.