jimnoneill/paper-to-field-training huggingface dataset:
S100A12 Mediates Aortic Wall Remodeling and Aortic Aneurysm

Field: Medicine (Health Sciences)

Rationale : S100A12 is a small calcium binding protein that is a ligand of RAGE (receptor for advanced glycation end products). RAGE has been extensively implicated in inflammatory states such as atherosclerosis, but the role of S100A12 as its ligand is less clear. Objective : To test the role of S100A12 in vascular inflammation, we generated and analyzed mice expressing human S100A12 in vascular smooth muscle under control of the smooth muscle 22α promoter because S100A12 is not present in mice. Methods and Results : Transgenic mice displayed pathological vascular remodeling with aberrant thickening of the aortic media, disarray of elastic fibers, and increased collagen deposition, together with increased latent matrix metalloproteinase-2 protein and reduction in smooth muscle stress fibers leading to a progressive dilatation of the aorta. In primary aortic smooth muscle cell cultures, we found that S100A12 mediates increased interleukin-6 production, activation of transforming growth factor β pathways and increased metabolic activity with enhanced oxidative stress. To correlate our findings to human aortic aneurysmal disease, we examined S100A12 expression in aortic tissue from patients with thoracic aortic aneurysm and found increased S100A12 expression in vascular smooth muscle cells. Conclusions : S100A12 expression is sufficient to activate pathogenic pathways through the modulation of oxidative stress, inflammation and vascular remodeling in vivo.
Liminality in Immigration-Adjacent Stories: A Critical Content Analysis of Identity Negotiation in Intercultural Graphic Novels

Field: Arts and Humanities (Social Sciences)

As educators and researchers with experiences related to historically marginalized students, we endeavored to provide a space to reveal their underrepresented stories, and we propose that intercultural graphic novels can serve as an emergent and transformative liminal space to help them navigate multiple identities. As a foundational step in the application of graphic novels in multilingual education, and under the tenets of Identity Negotiation Theory and Multimodality, we conducted a critical content analysis to examine six intercultural graphic novels. This study finds that the characters’ identity negotiation process- containing identity insecurity, identity inclusion, identity transformation, and “satisfactory” identity negotiation- forms a dynamic liminal space, and characters navigate in this in-between status. Also, we found that multiple modes contribute to revealing characters’ different identities and revealing their stories. Our findings will be helpful to inform additional studies on the use of graphic novels to embrace intercultural, immigrant, and immigrant-adjacent students’ voices in multilingual education.
JACOBI COHOMOLOGY, LOCAL GEOMETRY OF MODULI SPACES, AND HITCHIN CONNECTIONS

Field: Mathematics (Physical Sciences)

We develop some cohomological tools for the study of the local geometry of moduli and parameter spaces in complex Algebraic Geometry. Notably, we develop canonical formulae for the differential operators of arbitrary order and their natural action on suitable `natural' modules (for example, functions); in particular, we obtain a formula, in terms of the moduli problem, for the Lie bracket of vector fields on a moduli space. As an application, we obtain another construction and proof of flatness for the familiar KZW or Hitchin connection on moduli spaces of curves.
Philosophy of Psychotherapy

Field: Arts and Humanities (Social Sciences)

In our times of social eruptions not only the hierarchies of life but also those of coralled knowledge have become floating and therefore, papers presenting ideas of a certain generality must become accustomed to forsaking the habit of defining at the start the basic concepts. Renouncing a definition of the Webster type we will start with a very provisional definition of psychotherapy, hopeful that once more it might prove true that lifting one's eyes to the general will be more fruitful, if it is preceded by a stage of intimate knowledge of the particulars. Moreover, it is hoped that from such at the same time intimate and “philosophical” knowledge of one particular field a wholesome criticism, nay enriching effect might arise. It is the problems of detail that in our times have definitely turned to philosophy and it is these same problems which philosophy should delve into in its own interest.
Striatal extracellular levels of dopamine and its metabolites during kainate-induced limbic seizures in freely-moving rats measured by brain microdialysis

Field: Neuroscience (Life Sciences)

To investigate the role of brain dopaminergic systems in epilepsy, striatal extracellular levels of dopamins (DA) and its metabolites (3, 4-dihydroxyphenylacetic acid: DOPAC and homovanillic acid: HVA) were measured during kainate-induced limbic seizures in freely-moving rats, using brain microdialysis. DA and its metabolites were measured by high performance liquid chromatography. Systemic injection of kainate (10mg/kg, i. p.), which caused stable limbic seizures, significantly decreased the levels of DA and its metabolites. Intrahippocampal injection of kainae (2.5nmol), which also caused limbic seizures, significantly decreased only the DA levels, while DOPAC and HVA levels were unchanged. Similar to the results of the systemic injectjon, intrastriatal perfusion of kainate (10-2 or 10-6 M) significantly decreased the levels of DA, DOPAC and HVA in a dose-dependent manner. These findings indicate that, during kainate-induced limbic seizures, DA release was significantly reduced in the striatum. In conclusion, the hypofunction of striatal dopaminergic systems is related to the initiation and progress in epileptic seizures.
Quality indicators for the management of head and neck squamous cell carcinoma

Field: Health Professions (Health Sciences)

KEY MESSAGES. 1 -- SHORT REPORT. 3 -- 1. BACKGROUND 7 -- 1.1. QUALITY IMPROVEMENT INITIATIVES IN ONCOLOGY. 7 -- 1.2. HEAD AND NECK CANCER, A HETEROGENEOUS GROUP OF MALIGNANCIES AFFECTING VARIOUS SITES WITH DIFFERING PROGNOSES. 7 -- 1.3. SCOPE 7 -- 1.4. WHAT THIS STUDY AIMS AT AND DOES NOT AIM AT 7 -- 2. DATA AND METHODS. 8 -- 2.1. THE DATABASE - A LINKAGE BETWEEN THE BELGIAN CANCER REGISTRY AND ADMINISTRATIVE DATABASES. 8 -- 2.2. THE PATIENTS - DIAGNOSED IN 2009-2014, WITH EXCLUSION OF PATIENTS WITH MULTIPLE AND RECURRENT TUMOURS 9 -- 2.3. ASSIGNMENT OF PATIENTS TO A CENTRE OF DIAGNOSIS, A CENTRE OF MAIN TREATMENT AND A CENTRE OF FIRST TREATMENT 9 -- 2.4. CASE-MIX ADJUSTMENT 9 -- 2.5. IDENTIFICATION AND SELECTION OF POSSIBLE QUALITY INDICATORS 9 -- 2.6. VALIDATION STUDY AND SUBSEQUENT DATA CHECKS. 10 -- 2.7. STATISTICAL ANALYSES 10 -- 3. QUALITY OF CARE FOR PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA 11 -- 3.1. A COHORT OF 9 245 HNSCC PATIENTS DIAGNOSED IN 2009-2014 11 -- 3.2. MAIN THERAPEUTIC PROCEDURES: RADIOTHERAPY AND SURGERY 13 -- 3.3. LARGE DISPERSION OF CARE IN BELGIUM. 13 -- 3.4. RESULTS FOR 12 QUALITY INDICATORS 14 -- 3.4.1. Diagnosis and staging 15 -- 3.4.2. Treatment 18 -- 3.4.3. Safety of care – 30-day mortality after treatment with curative intent 20 -- 3.4.4. Survival after the diagnosis of HNSCC 22 -- 3.5. ASSOCIATION BETWEEN HOSPITAL VOLUME AND SURVIVAL 22 -- 4. STRENGTHS AND LIMITATIONS 24 -- 5. CONCLUSIONS AND PERSPECTIVES FOR THE FUTURE 26 -- RECOMMENDATIONS 28 -- REFERENCES 31
Identifying Muda in a fast food service process in Spain

Field: Business, Management and Accounting (Social Sciences)

Purpose Identification and elimination of Muda (any activity adding cost but not value from the customers’ perspective) is one of the main objectives of Lean service. Whilst there is significant research on implementing lean in manufacturing and some service industries, there is little information related to its application to the fast food service industry. The purpose of this paper is to try to fill in this gap by answering the research question: What type of Muda could be identified from the customers’ perspective within the service production processes in the fast food restaurant industry in Spain? Design/methodology/approach An exploratory case study has been conducted. Three multinational companies were selected and several sites observed in Madrid, Spain. Three methods were used to gather data: document analysis; direct and participative observation and semi-structured interviews. Findings The paper identifies the seven types of Muda : defects, movements, process, inventory, overproduction, transport and delay. The results are discussed for Cases A, B and C, showing that A and B present higher potential for Muda , compared C. Practical implications Threefold value for practitioners and managers: waste identification is an opportunity for non-efficient processes improvement; observation/analysis from the customers’ perspective reveals that customers perceive these inefficiencies; a guideline/audit tool for future assessments. Originality/value The paper contributes to the limited existing literature on lean service in fast food industry and disseminates this information to provide impetus, guidance and support toward increasing the productivity, efficiency, consistency and quality of service.
THE USE OF A READING CORNER IN INSTILLING THE STUDENTS READING INTEREST

Field: Social Sciences (Social Sciences)

Reading interests are very important to have mainly on students. Reading interests can come through support or without support is from inside someone's own heart. Student reading interests need to be resurrected from the age of elementary school, Surely the support and effort of teachers is essential in instilling reading interests. The research uses a type of qualitative research with case study designs. Data collection techniques use interviews, Observation and documentation. Data validity checks are performed through the source triangulation and engineering triangulation process. The data that's been obtained then reduced, presented, and the conclusion of the research suggests that the utilization of the reading corners in the SDN 1 Kemasan Sawit. In instilling an interest in reading is the use of teachers to make it easier for students to engage in literatory activities inside the classroom, is used for discussing and searching for material reference material students as well as for filling free time or during empty hours at class lesson in class. The management of the reading corner is done through four stages of planning, setting on motion, management and evaluation.
Influence of arbuscular mycorrhiza, gibberellic acid and kinetin on growth, quality parameters and petal senescence in gladiolus cv. Jessica

Field: Agricultural and Biological Sciences (Life Sciences)

An experiment was conducted to study the influence of arbuscular mycorrhiza (AM) and plant growth regulators on growth, quality parameters, petal senescence and post harvest life of gladiolus cv. Jessica. The field experiment was laid out in randomized block design, replicated thrice, with two levels of gibberellic acid, i.e. 100, 200 and kinetin, i.e., 50 and 100 ppm by dipping the corms overnight and foliar spray during growth period. The laboratory experiment was laid out in completely randomized design, replicated thrice, with sucrose 4 per cent and 8-HQC at 200 ppm as vase solution to increase the post-harvest life of flower. Pre-soaking and foliar spray of kinetin 50 ppm + AM was found to be the best for plant height, early emergence of spike, number of florets per spike and vase-life followed by pre-soaking and foliar spray of gibberellic acid 100 ppm + AM and pre-soaking with kinetin 50 ppm + AM. Reduced level of total protein, reducing sugar, starch, total anthocyanins, and total carotenoids content; and increased level of non-reducing sugar, and phenol content were noticed during petal senescence as compared to fresh, fully grown petals. However, higher concentration of kinetin and gibberellic acid reduced growth and post-harvest life of florets relative to lower concentration.
1 - Alakh Niranjan - I am above agency

Field: Arts and Humanities (Social Sciences)

Acharya Dr. Sthaneshwar Timalsina reflects on the meaning of Alakh Niranjan and recalls hearing it as a child growing up in Nepal. Relations ship between this saying and Lord #Shiva, The absolute state of consciousness. ***** Thank you for watching ***** Remember to like this video and subscribe to our channel. **** Follow us ***** X-Twitter: https://twitter.com/vimarshafdn Facebook: https://www.facebook.com/vimarshafoundation Instagram:https://www.instagram.com/vimarshafoundation/ **** Courses ***** Courses offered by Acharya Dr. Sthaneshwar Timalsina Introduction to Sarvāmnāya Tantra https://www.vimarshafoundation.org/challenge-page/introtosarvamnaya Yoga Vāsiṣṭha https://www.vimarshafoundation.org/challenge-page/yogavasistha Foundational Śaivism https://www.vimarshafoundation.org/challenge-page/foundationalsaivism See more: https://www.vimarshafoundation.org/courses **** Help us grow our foundation ****** https://www.vimarshafoundation.org/supportus **** About Vimarsha Foundation ***** Vimarsha Foundation is a modern school (gurukula) for teaching and reflecting on the ancient wisdom of r̥ṣis and siddhas. Through Vimarsha Foundation, a non-profit organization, Acharya Sthaneshwar teaches shastra and sādhanā to students of all backgrounds. The Vimarsha Foundation hosts free semester length courses on classic texts of the Tantric Tradition and offers many more free video and written teachings. Visit our website to learn more: https://www.vimarshafoundation.org/ **** Acharya Dr. Sthaneshwar Timalsina **** Acharya Dr. Sthaneshwar Timalsina is an esteemed traditionally consecrated teacher of Shaiva-Shakta Hindu Tantra. He is also the Endowed Chair of Indic Studies in New York, U.S.A. at Stony Brook University's College of Arts & Sciences in the Department of Asian & Asian-American Studies. Acharya Sthaneshwar founded Vimarsha Foundation as a modern school (gurukula) for teaching and reflecting on the ancient wisdom of r̥ṣis and siddhas. Through Vimarsha Foundation, a non-profit organization, Acharya Sthaneshwar teaches shastra and sādhanā to students of all backgrounds. The Vimarsha Foundation hosts free semester length courses on classic texts of the Tantric Tradition and offers many more free video and written teachings. Original YouTube video: https://www.youtube.com/watch?v=KsmlJEyXpig This presentation is part of the Sarvāmnāya Oral Tradition Archive. Vimarsha Foundation. (2025). The Sarvāmnāya Oral Tradition Archive [Data set]. Zenodo. https://doi.org/10.5281/zenodo.15188107
Are Current Protein Recommendations for the Critically Ill Adequate for Patients on VV ECMO: Experience From a High‐Volume Center

Field: Medicine (Health Sciences)

Abstract Background The nutrition needs of patients requiring extracorporeal membrane oxygenation (ECMO) have not been established in the literature. The purpose of this study is to investigate if current protein recommendations are adequate to achieve nitrogen equilibrium in patients on venovenous ECMO (VV ECMO). Methods Patients aged ≥18 years on VV ECMO admitted November 2016 through January 2018 with a documented nitrogen balance (NB) study were included. Patients were stratified by body mass index (BMI) into obese (BMI ≥ 30 kg/m 2 ) and nonobese (BMI < 30 kg/m 2 ) categories for analysis. Results After exclusions, 55 NB studies in 29 patients were analyzed. Twelve nonobese patients received a median of 2.1 g protein/kg actual body weight (ABW) (interquartile range [IQR]: 1.7–2.5), and median NB was −2.2 g/d (IQR: −7.4 to 2.8). In 17 obese patients, median protein delivery of 2 g protein/kg ideal body weight (IBW) (IQR: 1.7–2.5) achieved a median NB of −7.3 g/d (IQR: −12.6 to −2.8). Obese patients exhibited greater urinary urea nitrogen excretion than nonobese patients did (24.6 vs 17.6 g/d, P < 0.0001). Conclusions Obese and nonobese patients undergoing VV ECMO may require more protein than is currently recommended for critical illness. Monitoring nutrition delivery and serial NB to assess prescription adequacy should be incorporated into routine patient care. Further research is needed to confirm these findings and create specific guidelines for patients on VV ECMO.
Transneuronal Labeling of a Nociceptive Pathway, the Spino-(Trigemino-)Parabrachio-Amygdaloid, in the Rat

Field: Neuroscience (Life Sciences)

Transneuronal tracing of a nociceptive pathway, the spino-(trigemino)-parabrachio-amygdaloid pathway, was performed using an α-herpes virus, the Bartha strain of pseudorabies virus (PRV). Microinjection of PRV into the central nucleus of the amygdala (Ce) resulted in progressive retrograde and transneuronal infection of a multisynaptic circuit involving neurons in the brainstem and spinal cord as detected immunocytochemically. At short survival (26 hr), retrogradely labeled neurons were concentrated in the external lateral nucleus of the parabrachial complex (elPB) but were absent from both the trigeminal nucleus caudalis (TNC) and the spinal cord. At longer survivals (52 hr), labeled cells were present in lamina I of both the TNC and spinal dorsal horn. Retrograde labeling from the Ce with Fluoro-gold demonstrated that elPB neurons have long dendrites extending laterally into the terminal field of spinal and trigeminal afferents, where transneuronal passage of PRV to these afferents could occur. Even longer survivals (76 hr) resulted in a columnar pattern of cell labeling in the TNC and spinal dorsal horn that extended from lamina I into lamina II. At this longest survival, primary sensory neurons became infected. Bilateral excitotoxic lesions of the elPB blocked almost all viral passage from the Ce to superficial laminae of the TNC and spinal dorsal horn. These results demonstrate that nociceptive input to the amygdala is relayed from neurons in lamina I through the elPB. We propose that this modular arrangement of lamina I and II neurons may provide the basis for spinal processing of peripheral input to the amygdala.
Rapid Oscillations in Cataclysmic Variables. XV. HT Camelopardalis (= RX J0757.0+6306)

Field: Physics and Astronomy (Physical Sciences)

We present photometry and spectroscopy of HT Camelopardalis, a recently discovered X-ray-bright cataclysmic variable. The spectrum shows bright lines of H, He I, and He II, all moving with a period of 0.059712(1) d, which we interpret as the orbital period. The star's brightness varies with a strict period of 515.0592(2) s, and a mean full amplitude of 0.11 mag. These properties qualify it as a /bona fide/ DQ Herculis star (intermediate polar) -- in which the magnetism of the rapidly rotating white dwarf channels accretion flow to the surface. Normally at V=17.8, the star shows rare and very brief outbursts to V=12-13. We observed one in December 2001, and found that the 515 s pulse amplitude had increased by a factor of ~100 (in flux units). A transient orbital signal may also have appeared.
Upstream Hydraulics of a Run-of-the River Hydropower Facility for Fish Entrainment Risk Assessment

Field: Environmental Science (Physical Sciences)

Run-of-the-river hydropower is a typical form of power generation in mountainous regions. This study investigates the velocity field upstream of Aberfeldie dam, a run-of-the river facility on the Bull River near Wardner, British Columbia, Canada. As is typical for these types of run-of-the river facilities, the headpond of this dam is very shallow (approximately 1 m deep) because of long term sediment deposition. Near the facility's power intakes, a large scour hole has been created because of increased velocities induced by the intakes. This study conducted field measurements and developed a computational fluid dynamic (CFD) model to investigate the velocity field under various flow conditions. The CFD solver shows in a simplistic way that flow-induced bed shear stress likely causes a fluctuating, dynamic bed form that varies by season and the distance upstream, so that a consistent velocity pattern is seen across the entire headpond. The velocity field generated by the CFD solver is used to evaluate the entrainment risk of mountain whitefish and westslope cutthroat trout based on swimming mechanics and life stage. The unique habitat conditions generated by the scour hole act as an attractant to the high risk zone, greatly increasing fish density adjacent to the intakes at this facility.
Environmental Influences on the Distribution of Mangroves on Bahamas Island

Field: Agricultural and Biological Sciences (Life Sciences)

Mangrove forests provide valuable ecosystem services but are declining in many tropical locations. The abundance of mangrove species in coastal fringe forests is related to biotic processes such as species succession or competition and abiotic factors, including nutrient availability, physiochemical water quality, soil composition, and tidal inundation. We examined the abundance of Rhizophora mangle and Avicennia germinans relative to environmental factors, including porewater chemistry, soil substrate, and distance from the ocean, on Bahamas Island. In this system, R. mangle were primarily found in litter-dominated soils and abundances were positively related to distance from the ocean, while A. germinans was only found in sandy soils closest to the ocean. Although phosphate, alkalinity, and salinity in porewater did not explain the distribution of species, free chloride varied significantly with distance from the ocean. These results suggest that soil conditions and tidal inundation may help determine the distribution of mangrove species on Caribbean islands. DOI: http://dx.doi.org/10.3126/jowe.v6i0.6081 J Wet Eco 2012 (6): 16-24
Investor Inattention to All-Cash Acquisition Announcements: A Joint Day-Time Analysis in the Spanish Market

Field: Economics, Econometrics and Finance (Social Sciences)

Prior studies suggest that investors have limited attention, which determines the speed with which information is incorporated into share prices and, in turn, affects the efficiency of the markets. Unlike other corporate events, the information contained in an acquisition announcement is generally less standard and more complicated to process. Therefore, investor inattention is less likely around this event. In this study we test the existence of investor inattention for a sample of all-cash acquisition announcements of listed and unlisted target firms released by listed Spanish firms from 1998 to 2018. Cash acquisitions allow us to control for the strategic behavior of overvalued companies engaged in stock-financed acquisitions. We perform a joint analysis of day of the week and time of trade from both a univariate and a multivariate perspective, after controlling for several factors that are related to the market reaction to acquisition announcements. Consistent with the notion that investors are less attentive to Friday announcements, we find a significant lower market reaction to acquisition announcements released during market trading hours both in terms of price and trading volume.