jimnoneill/paper-to-field-training huggingface dataset:
Advances in the Research of Anti-CD44 Monoclonal Antibodies Mediated Therapy in Acute Myeloid Leukemia

Field: Medicine (Health Sciences)

CD44 is a widely distributed cell-surface glycoprotein involved in a variety of physiological and pathological processes. It plays a key role in the regulation of normal hematopoiesis, and especially it can induce terminal differentiation of hematopoietic stem/progenitor cells. CD44-ligation with specific monoclonal antibodies (H90, A3D8 and HI44a) can reverse the differentiation blockage of leukemic blasts in some AML subtypes (from M1 to M5), and subsequently it can transform the cytologic and antigenic features of AML malignant cells to those of normal myeloid cells. This paper reviews the differentiative and apoptotic effects of anti-CD44 mAbs in AML cells and their possible mechanisms and the prospect of using CD44-targated therapy for AML.
An inherited defect in granulocyte function: impaired chemotaxis, phagocytosis and intracellular killing of microorganisms.

Field: Medicine (Health Sciences)

The neutrophil granulocytes of a 1-year-old boy with severe recurrent infections were found to have almost no chemotactic responsiveness, impaired phagocytosis and reduced intracellular killing of Candida albicans "in vitro". During the course of a febrile illness of unknown etiology which was accompanied by a leukemoid reaction, phagocytic activity became normal; the chemotactic response was also increased but still remained slightly subnormal. Family studies suggested that the defect was an inherited autosomal recessive one.
Predicting Feature-based Similarity in the News Domain Using Human Judgments

Field: Computer Science (Physical Sciences)

When reading an online news article, users are typically presented ‘more like this’ recommendations by news websites. In this study, we assessed different similarity functions for news item retrieval, by comparing them to human judgments of similarity. We asked 401 participants to assess the overall similarity of ten pairs of political news articles, which were compared to feature-specific similarity functions (e.g., based on body text or images). We found that users indicated to mostly use text-based features (e.g., title) for their similarity judgments, suggesting that body text similarity was the most representative for their judgment. Moreover, we modeled similarity judgments using different regression techniques. Using data from another study, we contrasted our results across retrieval domains, revealing that similarity functions in news are less representative of user judgments than those in movies and recipes.
State of the art technologies to explore long non‐coding RNAs in cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract Long non‐coding RNAs (lncRNAs) comprise a vast repertoire of RNAs playing a wide variety of crucial roles in tissue physiology in a cell‐specific manner. Despite being engaged in myriads of regulatory mechanisms, many lncRNAs have still remained to be assigned any functions. A constellation of experimental techniques including single‐molecule RNA in situ hybridization (sm‐RNA FISH), cross‐linking and immunoprecipitation (CLIP), RNA interference (RNAi), Clustered regularly interspaced short palindromic repeats (CRISPR) and so forth has been employed to shed light on lncRNA cellular localization, structure, interaction networks and functions. Here, we review these and other experimental approaches in common use for identification and characterization of lncRNAs, particularly those involved in different types of cancer, with focus on merits and demerits of each technique.
Low-cost scanning LIDAR architecture with a scalable frame rate for autonomous vehicles

Field: Engineering (Physical Sciences)

Autonomous vehicles need accurate 3D perception with a decent frame rate and high angular resolution to detect obstacles reliably and avoid collisions. We developed a low-cost scanning multichannel light detection and ranging sensor architecture allowing scalable frame rates by adjusting the number of laser and detector pairs. Scanning is achieved by a pair of micro–electro–mechanical system (MEMS) mirrors. A control pattern for the MEMS mirrors to maximize the frame rate is presented. A built prototype based on the proposed architecture achieves a frame rate of 11.5 Hz, a field of view of 70 ∘ × 30 ∘ , and an angular resolution of 0.4°. The distance resolution is 6 cm. Reliable single-shot detection for low-reflective objects up to 19 m indoors and 11 m under direct sunlight exposure is achieved. A performance assessment based on the presented measurement system for recently available vertical-cavity surface-emitting laser arrays with power densities up to 1 k W / m m 2 shows promising improvement potential.
The role of placental indoleamine 2,3-dioxygenase in human pregnancy

Field: Medicine (Health Sciences)

Munn et al. made a scientific observation of major biological importance. For the first time they showed that in the mammal the fetus does survive an immune attack mounted by the mother, and that the mechanism responsible for the survival depends on the fetus and placenta 'actively' defending itself from attack by maternal T cells by means of an enzyme indoleamine 2,3-dioxygenase (EC 1.13.11.42) dependent localised depletion of L-tryptophan. These findings raise critical questions for disease and its prevention during human pregnancy. Specifically, the role of this mechanism (discovered in mouse) in the human, and the extent to which defective activation of this process is responsible for major clinical diseases are unknown. Therefore some key facts about this enzyme expressed in the human placenta have been studied in order to test whether Munn et al.'s findings in mouse are met for human pregnancy. This short review attempts to describe our experimental work on human placental indoleamine 2,3-dioxygenase.
Subcellular basis of vitamin C protection against doxorubicin-induced changes in cardiomyocytes and Sca-1 positive cells

Field: Medicine (Health Sciences)

Understanding the molecular basis of doxorubicin (Dox)-induced oxidative stress leading to cardiomyopathy is crucial to finding cardioprotective strategies to manage this important clinical problem. Improving the antioxidant defenses of cardiac cells could be one strategy for cardioprotection. The role of oxidative stress in Dox-induced cardiotoxicity as well as testing the efficacy of antioxidant Vitamin C (Vit C) in offering protection to cardiomyocytes was investigated. As stem cells have been suggested to play a role in this cardiotoxicity, Dox-mediated oxidative stress effects, with and without Vit C, on the stem cell antigen-1 (Sca) positive cells from heart as well as bone marrow were also examined. Our time-course studies of the effects of Dox on the isolated cardiomyocytes showed that the phosphorylation of mitogen-activated protein kinases and p53 followed the rise in reactive oxygen species (ROS) production. Dox also downregulated the Sodium-dependent Vit C Transporter-2 (SVCT-2) and this may have enhanced Dox-induced increase in oxidative stress. Pro-apoptotic markers Bax/Bcl-xL ratio and caspase 3 cleavage were higher after the activation of stress-induced pathways and viability of cells was decreased. Dox-induced increase in apoptosis and decrease in cell viability depended in part on the activation of p38/JNK and p53 proteins, but not on the ERK protein. Exposure to Dox, increased membrane leakage, autophagy and lipid peroxidation. On the other hand, Dox decreased overall antioxidant capacity as well as expression of the endogenous antioxidant enzymes glutathione peroxidase, Cu/Zn superoxide dismutase and catalase. Dox affected Sca-1 positive cells in a prominent manner which was marked by a dose-dependent increase in cell loss, cell leakage and ROS levels as well as decrease in cellular ATP levels. Vit C pre-treatment prior to the addition of Dox delayed and reduced Dox-induced injury to cardiomyocytes, preserving viability. Vit C was able to blunt the decrease in SVCT-2 as well as Dox-induced oxidative stress. Vit C also offered protection to Sca-1 positive cells by partially preventing Dox-induced changes to these cells. The data presented in this thesis improves our knowledge of the molecular mechanisms leading to Dox-induced cardiotoxicity as well as suggest cardioprotection by Vit C.
Identity and Performance in Restaurants

Field: Social Sciences (Social Sciences)

This paper will discuss different methods that restaurants use to express their identity, in what ways they act as symbols of identity, and how they act as social performances of identity. The specific focus is on foreign restaurants in Brno, and how different cultural scripts interact in the realm of the restaurant. The analysis will cover how restaurants tend to frame and structure symbolic meaning. The collected data will include interviews with owners and staff, restaurant names, the menus, and various aesthetic observations. The analysis itself will be focused on Erving Goffman's and Jeffrey Alexander’s works on performance and presentation.
Behavior of Adsorption of CO[sub 2] onto Iron Powder During Dry Grinding

Field: Chemistry (Physical Sciences)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Nik Hisyamudin Muhd Nor, Seiji Yokoyama, Tatsuya Suzuki; Behavior of Adsorption of CO2 onto Iron Powder During Dry Grinding. AIP Conf. Proc. 17 January 2011; 1315 (1): 1493–1498. https://doi.org/10.1063/1.3552398 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Multiple wavelength semiconductor laser device array and production method

Field: Engineering (Physical Sciences)

The present invention provides a multiple wavelength semiconductor laser device array having approximately the same optical output levels of inducing kink and COD. The multiple wavelength semiconductor laser device array has the same construction as that of a conventional two-wavelength semiconductor laser device array except the thickness of the reflection films at the light emitting end faces. The thickness of the reflection films deposited on the light emitting end faces of the two-wavelength semiconductor laser device array is determined so as to have a lower reflectivity at a light emitting end face of a 650 nm band semiconductor laser device consisting of an AlGaInP type four-element compound semiconductor which may induce kink and COD more easily, than a reflectivity at a light emitting end face of a 780 nm band semiconductor laser device consisting of an AlGaAs type three-element compound semiconductor.
Process of the selective reduction and recovery of iron from copper tailings

Field: Chemical Engineering (Physical Sciences)

Copper tailings are potential resources rich in iron minerals and their long-term stockpiling not only cause resource waste but also bring serious pressure to the ecological environment. Therefore, the resource utilization of copper tailings has attracted considerable attention and becomes the key to the sustainable development of the copper industry. In this study, the technology of the selective reduction of iron from copper tailings at low temperature using coal and recovery of iron from reduction pellets using magnetic separation was proposed. The effects of several factors, such as reduction temperature, reducing agent dosage, reduction time, and activator dosage, on the selective reduction and recovery of iron from copper tailings were investigated. The following optimum process conditions are determined through single-factor experiments: the reduction temperature is 1200℃, the reducing agent dosage is 25% of the mass of copper tailings, the reduction time is 2 h, and the activator dosage is 5% of the mass of copper tailings. Under the optimum process conditions, the iron mass fraction of the magnetic concentrate exceeds 90%, and the iron recovery rate is greater than 95%. The composition and structure of copper tailings, reduction pellets, and magnetic ores were determined via X-ray diffraction, optical microscopy, and scanning electron microscopy. Moreover, the mechanism of mineral phase reduction and metal phase generation/merging was revealed. The results show that increase in temperature is beneficial for the reduction, merging, and growth of the metal phase. Merging the metal particles becomes common by increasing the reducing agent dosage. Prolonging the reduction time promotes the merging of metal particles and reduction of fayalite. The activator promotes the diffusion and merging of metal particles. The merging and growth of metal particles promote the increase in particle size. The amount of slag wrapped by coarse metal particles in the magnetic concentrate is relatively small in the magnetic separation process, and the iron grade of the magnetic concentrate is significantly improved.
Reuse a Repository of Conceptual Schemas in a Large Scale Project

Field: Computer Science (Physical Sciences)

This chapter describes a methodology and a tool for the reuse of a repository of conceptual schemas. Large amounts of data are managed by organizations, with heterogeneous representations and meanings. Since data are a fundamental resource for organizations, a comprehensive and integrated view is needed for it. The concept of data repository fulfils these requirements, since it contains the description of all types of data produced, retrieved, and exchanged in an organization. Data descriptions should be organized in a repository to enable all the users of the information system to understand the meaning of data and the relationships among them. The methodology described in the chapter is applied in a project where an existing repository of conceptual schemas, representing information of interest for central public administration, is used in order to produce the corresponding repository of the administrations located in a region. Several heuristics are described and experiments are reported.Request access from your librarian to read this chapter's full text.
RESEARCH ARTICLE Traffic Modelling Framework for Electric Vehicles

Field: Engineering (Physical Sciences)

This paper reviews and improves a recently proposed model of road network dynamics. The model is also adapted and generalised to represent the patterns of battery consumption of electric vehicles traveling in the road network. Simulations from the mobility simulator SUMO are given to support and to illustrate the efficacy of the proposed approach. Applications relevant in the field of electric vehicles, like optimal routing and traffic load control, are provided to illustrate how the proposed model can be used to address typical problems arising in contemporary road network planning and electric vehicle mobility.
[Incorporation of 1-14C-glycine into total protein and subcellular fractions of rat liver at different periods following administration of tetrachlormethane].

Field: Immunology and Microbiology (Life Sciences)

<p>Antigen cross-presentation describes the process through which dendritic cells (DCs) acquire exogenous antigens for presentation on MHC class I molecules. The ability to cross-present has been thought of as a feature of specialized DC subsets. Emerging data, however, suggest that the cross-presenting ability of each DC subset is tuned by and dependent on several factors, such as DC location and activation status, and the type of antigen and inflammatory signals. Thus, we argue that capacity of cross-presentation is not an exclusive trait of one or several distinct DC subtypes, but rather a common feature of the DC family in both mice and humans. Understanding DC subset activation and antigen-presentation pathways might yield improved tools and targets to exploit the unique cross-presenting capacity of DCs in immunotherapy.</p>
Breakthrough Data Analysis of Adsorption of Toluene Vapor in a Fixed‐Bed of Granular Activated Carbon

Field: Chemical Engineering (Physical Sciences)

Abstract Toluene vapor was adsorbed in a laboratory‐scale packed‐bed adsorber using granular activated carbon (GAC) at constant pressure (101.3 kPa). The adsorber was operated batchwise with the charge of GAC in the range of 2–4 g to obtain the breakthrough curves of toluene vapor. Experiments were carried out at different adsorption temperatures (25–50°C), sparger temperatures (20–30°C), and the flow rates of nitrogen (80–150 cm3/min) to investigate the effects of these experimental variables on the breakthrough curves. The deactivation model was tested for these curves by combining the adsorption of toluene vapor and the deactivation of adsorbent particles. The observed values of the adsorption rate constant and the deactivation rate constant were evaluated through analysis of the experimental breakthrough data using a nonlinear least squares technique. The experimental breakthrough data were fitted very well to the deactivation model than the adsorption isotherm models in the literature.
Evaluasi Reklamasi di Area Pertambangan Batubara PT. PQ, Kecamatan Tanjung Kidul, Kabupaten Muara Enim, Provinsi Sumatera Selatan

Field: Environmental Science (Physical Sciences)

Coal mining activities carried out by PT. PQ causes a change in the environmental setting so that its function needs to be restored according to its designation. The return of land function is carried out through reclamation activities. Reclamation activities need to be evaluated in order to continue to make improvements and optimal results. This study assesses the success rate of reclamation carried out by PT. PQ. This study aims to examine and evaluate the reclamation activities carried out by PT. PQ is based on Decree of the Minister of Energy and Mineral Resources Number 1827/30 K/MEM of 2018. The research method used is field observation; analysis of primary and secondary data on land use, revegetation, and maintenance stages; and mathematical calculation of reclamation success rate. Soil quality was tested by testing the pH of H2O, organic C, and total N. The results showed that the soil in the reclamation area is considered to be acidic, namely the pH of H2O is 4.5 -5.5; organic C by 1-2%; N total of 0.1 – 0.2%; C/N of 5 – 1 test for pH H2O, organic C, and N total reclamation success rate of 94.1 or in the good category. The soil in the reclamation area has a pH of 4.3 and a soil organic C content of less than 1%. The main eucalyptus oil plants require soil with a pH of 4.5 -5.5. organic C by 1-2%; N total of 0.1 – 0.2%; C/N of 5 – 1. To complete the reclamation activities, it is necessary to increase the pH of the soil, which is still acidic, namely 4.3 and to increase the organic C content of the soil, which is still low, namely <1%. Findings of acidic soil pH and soil organic C content below the standard needed for the main plant eucalyptus oil are initial information for improving soil conditions in the reclamation area of PT. PQ so that reclamation activities run better.
Determination of Hydrocyanic Acid in Air and in Air-Carbon Dioxide Mixtures

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Hydrocyanic Acid in Air and in Air-Carbon Dioxide MixturesH. L. CupplesCite this: Ind. Eng. Chem. Anal. Ed. 1933, 5, 1, 50–52Publication Date (Print):January 1, 1933Publication History Published online1 May 2002Published inissue 1 January 1933https://pubs.acs.org/doi/10.1021/ac50081a027https://doi.org/10.1021/ac50081a027research-articleACS PublicationsRequest reuse permissionsArticle Views37Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Yours Sincerely, John M. Macfarlane

Field: Arts and Humanities (Social Sciences)

Book Review| January 01 1981 Yours Sincerely, John M. Macfarlane Yours Sincerely, John M. Macfarlane, L. W. Macfarlane. Wayne K. Hinton Wayne K. Hinton Search for other works by this author on: This Site Google Utah Historical Quarterly (1981) 49 (1): 100–101. https://doi.org/10.2307/45060795 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Wayne K. Hinton; Yours Sincerely, John M. Macfarlane. Utah Historical Quarterly 1 January 1981; 49 (1): 100–101. doi: https://doi.org/10.2307/45060795 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveUniversity of Illinois PressUtah Historical Quarterly Search Advanced Search The text of this article is only available as a PDF. © Copyright 1981 Utah State Historical Society1981 Article PDF first page preview Close Modal Issue Section: Book Reviews You do not currently have access to this content.
Achieving hardware-efficient neural network based pattern recognition system through linear approximation

Field: Computer Science (Physical Sciences)

The limitations of traditional computers and the advent of real-time applications dictate the need for a dedicated hardware to realize complex neural network models that are widely used in pattern recognition systems. It has been shown that the computational bottleneck of the neural network architecture lies in the activation function. In this paper, we present an area-time efficient neural network engine that employs linear approximation to reduce the computational complexity of the activation function. It is demonstrated that the approximation method can achieve a high degree of recognition accuracy by trading-off the number of recognizable patterns. Hardware implementation results show that the proposed method has approximately 42% performance gain over the previous implementation with a hardware reduction of 123K NAND gates. The approach in this paper lends well for low-cost and high-speed portable applications such as intelligent toys.