jimnoneill/paper-to-field-training huggingface dataset:
Influence of excipients in antiglaukoma eye drops on quality of life index based on criteria of side effects frequency

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Following the growth of overall morbidity, environmental degradation, social and economic vulnerability of the population, the demand for the effective and cheap medicines, which can provide an individual approach to the patient, is increasing. This can be achieved by taking into account not only peculiarities of the pharmacological action of medicines, but also the nomenclature of excipients.
The aim of this article was to study the nomenclature, technological properties, side effects and the influence of excipients on the quality of patients’ life.
There were analyzed 247 questionnaires assessing the quality of patients’ life with primary open-angle glaucoma to determine the frequency of side effects from the drug therapy. In order to determine the range and purpose of excipients, the marketing and merchandising analysis of eye drops S01E group – «Antiglaucoma agents and miotiks» available at the domestic pharmaceutical market were conducted.
Marketing analysis of the Ukrainian pharmaceutical market had shown the presence of 48 antiglaucoma medicines in the form of eye drops, which contain sympathomimetics, parasympathomimetics, carbonic anhydrase inhibitors, beta-adrenergic blockers, prostaglandin analogs.
The adjuvants for group S01E – «Antiglaucoma agents and miotiks» are solvents (100%), stabilizers (22.92%), isotonizing agents (39.58%), prolongators (52.08%), preservatives (100 %), buffers (72.92%), substances - pH regulators (39.58%), solubilizers (44.17%).
The most common preservative in antiglaucoma eyedrops is benzalkonium chloride. The chemical stability of the active ingredients is provided mainly by the addition of disodium edetate.
As a result of the analysis of forms «Quality of life in patients with primary open angle glaucoma» it has been set, that the correlation coefficient between the contents of auxiliary substances and frequency of side effects of antiglaucoma eyedrops ranges from 0.5 to 0.7, indicating a significant excipients impact on quality of patients’ life.
Understanding early mouse embryonic development using single-cell mRNA-sequencing

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Biomedical research often involves the use of cell lines that can be cultured in a laboratory. Individual cells within such cell lines often share a similar morphology. A remarkable exception are in vitro cultured mouse Embryonic Stem Cells (mESCs) - pluripotent cells derived from the blastocyst stage of the mouse developing embryo. Different from many other cell lines, mESCs show heterogeneity in morphology and gene expression between the individual cells within a population. This heterogeneity makes it challenging to characterise mESCs at a molecular level, since global profiling methods generally require large numbers of cells. However, new methods and technologies allow global transcriptome profiling of individual cells. By capturing the global transcriptome of many individual cells using single-cell next-generation mRNA-sequencing, our research focuses on the identification of novel transcription factor modules that contribute to the unique pluripotent state of mESCs, as well as to the differentiation of mESCs, as a model for early mouse embryonic development.
DOES THE ERADICATION OF HELICOBACTER PYLORI CURE DUODENAL ULCER DISEASE IN COMMUNITIES WITH A HIGH PREVALENCE RATE? COMPARISON WITH LONG‐TERM ACID SUPPRESSION

Field: Medicine (Health Sciences)

SUMMARY The long‐term effect of Helicobacter pylori eradication on the natural history of duodenal ulcer has been investigated and compared with long‐term acid suppression treatment in an endemic community for infection. Seventy‐three patients with endoscopically verified H. pylori positive active duodenal ulcer disease were included in this prospective study. Patients were divided into two groups. Group A patients (n=39) were given an omeprazole‐based triple eradication regimen, while group B patients (n=34) were given omeprazole alone followed by long‐term famotidine 20 mg daily as maintenance treatment. A control endoscopy was performed at the third month of treatment. The bacterium was eradicated in 32 (82%) of group A patients. All patients were followed up for two years and an endoscopy performed at the end of each year. H. pylori recurred in 13 patients and the reinfection rate was 44.8% over two years. Duodenal ulcer recurred in seven of these patients at two years (24.1%). There was a close association between H. pylori reinfection and ulcer relapse. Group B patients remained H. pylori positive during the study and the ulcer recurred in five of these patients (16.6%) despite continuous famotidine treatment. There was no statistically significant difference in ulcer relapse rate between the groups. These results suggested that H. pylori eradication is not an absolute solution for duodenal ulcer disease in high endemic regions and continuous maintenance treatment with H 2 ‐receptor antagonists is still an alternative approach in some chronic recurrent cases.
Four new resin glycosides, calyhedins VII–X, from the rhizomes of Calystegia hederacea

Field: Chemistry (Physical Sciences)

Four new resin glycosides with macrolactone structures (jalapins), namely, calyhedins VII (1)-X (4), were isolated from the rhizomes of Calystegia hederacea Wall. (Convolvulaceae). The structures of 1-4 were determined based on spectroscopic data. They were classified into three ring types: a 27-membered ring (1), a 22-membered ring (2, 3), and a 23-membered ring (4). Their sugar moieties were partially acylated using five organic acids, including (E)-2-methylbut-2-enoic acid, 2S-methylbutyric acid, and 2 R-methyl-3R-hydroxybutyric acid. Compound 4 was the first genuine resin glycoside with calyhedic acid F as the glycosidic acid component. Additionally, the cytotoxic activities of 1, 2, and 4 towards HL-60 human promyelocytic leukaemia cells were evaluated. All compounds demonstrated almost the same activity as the positive control, cisplatin.
Supplementary Figure S1 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

<p>A, miR-409-5p and miR-409-3p binding sties in 3`UTR of RSU1 mRNA. B, Effect miR-409-5p mimic binding on 3` UTR of RSU1 luciferase construct, both wild type and mutated construct. Effect of miR-409-5p mimic and miR-409-3p mimic on STAG2 3`UTR luciferase construct measured by luciferase assay.</p>
Public Order, Social Drama, and Legitimate Force

Field: Social Sciences (Social Sciences)

This chapter explores the contrast between Taiwan’s Sunflower Movement and Hong Kong’s Umbrella Movement as a natural experiment in comparative policing. I look at the different roles played by police within the larger historical dynamics of these two events. My goal is to distinguish the democratic qualities of Taiwanese policing from the more authoritarian qualities evident in Hong Kong. I develop a theoretical framework for analyzing this distinction by combining Peter Manning’s idea of police dramaturgy with Victor Turner’s theory of social dramas and Carl von Clausewitz’ approach to violent politics. This perspective, I argue, helps illuminate how the democratic qualities of police action in response to unsettling events can influence the longer historical/structural patterns linking what comes after to what went before.
MERLIN high energy laser source for methane sensing at 1645 nm

Field: Physics and Astronomy (Physical Sciences)

MERLIN (Methane remote sensing LIDAR mission) is a joint DLR/CNES mission, which will measure column densities of methane in the Earth atmosphere. The heart of the instrument is the laser transmitter subsystem, developed and built by Airbus (Ottobrunn, Germany) in cooperation with the Fraunhofer Institute for Laser Technology (Aachen, Germany), being in charge of the laser’s optomechanical assembly. The project is currently in Phase D with an expected instrument delivery date to the satellite prime in 2026 and launch in 2028. The laser system features key technologies, as already demonstrated successfully in the frame of the FULAS project, to enable reliable long term and high-stability laser performance operation under space conditions. The technologies are optimized with respect to thermal and mechanical stability and developed with special attention on LIC (laser induced contamination) issues by aiming for a fully inorganic design, avoiding any critical organic and outgassing materials. This publication provides an insight into the system design. Furthermore first results from the ongoing qualification model assembly and integration activities are presented, including evidence of the technology maturity for space, based on subassembly and component level qualifications as well as representative bread board activities. Additional presentation content can be accessed on the supplemental content page.
Peptide receptor radionuclide therapy induced carcinoid crisis: A case report.

Field: Medicine (Health Sciences)

Peptide receptor radionuclide therapy (PRRT) is a therapeutic option in inoperable or metastatic neuroendocrine tumours (NETs). PRRT proved to be promising in prolonging survival and delaying disease progression in patients with advanced bronchopulmonary carcinoid. However, it may lead to worsening of carcinoid symptoms or even precipitate carcinoid crises. The incidence of PRRT induced carcinoid crisis would be between 1-10%. This usually takes place during the first PRRT cycle, either during the tracer infusion or 12-48 hours' post-administration. We report a 62-year-old man with underlying metastatic lung carcinoid tumour who developed carcinoid crisis at 10 hours after receiving PRRT. The carcinoid crisis was successfully treated with intravenous octreotide infusion, corticosteroid, a selective 5-HT3 receptor antagonist, parenteral ranitidine and chlorpheniramine for H1 and H2 antagonism respectively.
Correction: Efficient biomass saccharification using a novel cellobiohydrolase from Clostridium clariflavum for utilization in biofuel industry

Field: Chemical Engineering (Physical Sciences)

Correction for ‘Efficient biomass saccharification using a novel cellobiohydrolase from Clostridium clariflavum for utilization in biofuel industry’ by Asma Zafar et al., RSC Adv., 2021, 11, 9246–9261, DOI: 10.1039/D1RA00545F.
Green Fluorescent Protein-ExpressingEscherichiacolias a Model System for Investigating the Antimicrobial Activities of Silver Nanoparticles

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Recombinant Escherichia coli (E. coli) bacteria expressing green fluorescent protein (GFP) was used as a model system to investigate the antimicrobial activities of Ag nanoparticles (NPs). A convenient in situ method of Ag NP synthesis using sodium borohydride, in the bacterial growth medium, was developed to produce preformed NPs for the study. Fluorescence spectroscopic and microscopic techniques allowed rapid detection of time-dependent changes in bacterial growth as well as fluorescence characteristics in the presence of Ag NPs. In addition, X-ray diffraction, UV-vis spectroscopic, and transmission electron microscopic measurements were carried out to understand the effect of Ag NPs on the bacteria. Our observations indicated that Ag NPs, above a certain concentration, not only were bactericidal but also were found to reduce the sizes of treated bacteria in comparison to untreated ones. Cell lysis of Ag NP-treated bacteria was suggested by the increased GFP fluorescence obtained in the medium. In vitro DNA-Ag NP interaction was detected by spectrophotometric analysis. However, electrophoresis studies indicated no direct effect of Ag NPs on DNA or protein profiles.
The Relationship Between Financial Wellness and Job Performance in Employees of PDAM Tugu Tirta in Malang City

Field: Economics, Econometrics and Finance (Social Sciences)

Job performance is a crucial criterion related to organizational outcomes and success. One of the factors that influence job performance is individual financial wellness. This research examines the relationship between financial wellness and job performance among employees of PDAM Tugu Tirta in Malang City. This research utilized a quantitative, non-experimental correlational method. The sample consisted of 100 employees of PDAM Tugu Tirta in Malang City, selected using an accidental sampling technique. The instruments employed were the Personal Financial Wellness Questionnaire and the Individual Job Performance Questionnaire. The data analysis involved the use of Pearson's product-moment correlation analysis. The analysis results indicate that financial wellness has a significant positive relationship with job performance (rxy equals .662; Sig. equals 0.00).
On the Use of Soft Computing Techniques for Web Personalization

Field: Computer Science (Physical Sciences)

Due to the growing variety and quantity of information available on the Web, there is urgent need for developing Web-based applications capable of adapting their services to the needs of the users. This is the main rationale behind the flourishing area of Web personalization that finds in soft computing (SC) techniques a valid tool to handle uncertainty in Web usage data and develop Web-based applications tailored to user preferences. The main reason for this success seems to be the synergy resulting from SC paradigms, such as fuzzy logic, neural networks, and genetic algorithms. Each of these computing paradigms provides complementary reasoning and searching methods that allow the use of domain knowledge and empirical data to solve complex problems. In this chapter, we emphasize the suitability of hybrid schemes combining different SC techniques for the development of effective Web personalization systems. In particular, we present a neuro-fuzzy approach for Web personalization that combines techniques from the fuzzy and the neural paradigms to derive knowledge from Web usage data and represent the knowledge in the comprehensible form of fuzzy rules. The derived knowledge is ultimately used to dynamically suggest interesting links to the user of a Web site.
Scalable and Resilient 360-degree-Video Adaptive Streaming over HTTP/2 against Sudden Network Drops

Field: Computer Science (Physical Sciences)

Realistic Virtual Reality is supported by 360° video, which provides viewers with an immersive watching experience. However, 360° video is bulky in size, while the transmission system has limited ability to provide bandwidth. As such, intelligent adaptive delivery solutions play a crucial role in enabling users to stream high-quality 360° video. In this research, we propose a novel approach for 360-degree video streaming over HTTP/2 that can provide consumers with a good watching experience (QoE) even in varying network circumstances and head-eye movements over time. The proposed method deploys the so-called BBAG algorithm (Buffer and Bandwidth Allocation Algorithm) using Scalable Video Coding to choose appropriate tile layers to resolve the trade-off between network and user adaptivity. With the support of HTTP/2's stream termination capability, the delivery of late tile layers is terminated to handle abrupt interruptions. BBAG is proven to improve QoE from 3.56% to 93.71% and the average viewport bitrate from 1.78% to 80.49% compared to state-of-the-art methods.
Protein tyrosine phosphatase receptor type C (PTPRC or CD45)

Field: Immunology and Microbiology (Life Sciences)

The leucocyte common antigen, protein tyrosine phosphatase receptor type C (PTPRC), also known as CD45, is a transmembrane glycoprotein, expressed on almost all haematopoietic cells except for mature erythrocytes, and is an essential regulator of T and B cell antigen receptor-mediated activation. Disruption of the equilibrium between protein tyrosine kinase and phosphatase activity (from CD45 and others) can result in immunodeficiency, autoimmunity, or malignancy. CD45 is normally present on the cell surface, therefore it works upstream of a large signalling network which differs between cell types, and thus the effects of CD45 on these cells are also different. However, it is becoming clear that CD45 plays an essential role in the innate immune system and this is likely to be a key area for future research. In this review of PTPRC (CD45), its structure and biological activities as well as abnormal expression of CD45 in leukaemia and lymphoma will be discussed.
DISCOVERY OF THE PREDATORY MITE PHYTOSEIULUS PERSIMILIS ATHIAS‐HENRIOT (ACARINA: PHYTOSEIIDAE) IN AUSTRALIA

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Phytoseiulus persimilis Athias‐Henriot (Phytoseiidae) was discovered near Sydney in December 1978 in association with Tetranychus urticae (Koch) (Tetranychidae) on commercial strawberries. It is the first time that this species has been recorded in Australia.
Initial Performance of Tissue Culture Raised Bamboos in Rajasthan and Gujarat

Field: Agricultural and Biological Sciences (Life Sciences)

Keeping in view the low productivity of forestry plantations in Rajasthan and Gujarat, an effort has been initiated to enhance the productivity of bamboo plantations using improved planting material raised either through clonal methods or through tissue culture. These trials have been established at Chakhalia, Jhalod (Gujarat); Kushalgarh (Rajasthan). In total 50 ha area has been covered under these specialty plantations, the bamboo species considered for planting are Dendrocalamus strictus and Bambusa bambos . In these performance trials some experimentation were also laid out to see the effect of soil amelioration using organic and inorganic manures and effect of spacing on the growth and productivity of the bamboo plantations. The spacing used are 5m × 5m and 6m × 6m. The initial establishment's results are quite encouraging in both the states. In Gujarat survival percentage ranges from 97.2 % to 100.0% for both the species whereas in Rajasthan sites it was 67.6% to 96.8% (Kushalgarh). The differences observed in the survival percentage may be due to altitudinal variations as the altitude of Gujarat site is 259 m amsl whereas it was 457.20 m amsl for Rajasthan sites. The overall growth performance of both the species is quite satisfactory. Initial inferences can be drawn from these trials is that bamboos can be introduced in both the states in Agroforestry systems.
Oryza sativa L. JP 13046

Field: Agricultural and Biological Sciences (Life Sciences)

Plant Genetic Resource.
Taxonomy: Oryza sativa L.
Common name(s): Paddy rice
Other names: ANNAPURNA
Conserved by: NARO Genebank (NARO), Japan
Local sample unique identifier: JP 13046
Method of creation: Acquisition
Date: 1982-08-07
Historical: No
Biological status: Other
MLS status: Included
Recycling of autophagosomal components from autolysosomes by recycler complex

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Abstract

Autolysosomes contain components both from autophagosomes and lysosomes. The contents inside the autophagosomal lumen are degraded during autophagy, while the fate of autophagosomal components on autolysosomal membrane remains unknown. Here, we found the autophagosomal membrane and transmembrane proteins are not degraded, but recycled from autolysosomes. We named this process autophagosomal components recycling (ACR). We further identified a multiprotein complex composed of SNX4, SNX5 and SNX17 essential for ACR which we termed “recycler”. In this, SNX4 and SNX5 form a heterodimer that recognizes an autophagosomal cargo STX17 and is required for generating membrane curvature on autolysosomes both via their BAR domains, to mediate the cargo sorting process. SNX17 interacts with both the dynein-dynactin complex and the SNX4-SNX5 dimer to facilitate retrograde transport of STX17. Depletion of any subunit of recycler completely blocks ACR, and also inhibits autophagy. Our discovery of ACR and identification of recycler reveal an important retrieval and recycling pathway on autolysosomes.
Diversification and species limits in scale-backed antbirds (Willisornis: Thamnophilidae), an Amazonian endemic lineage

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract The genus Willisornis is endemic to the Amazon Basin, inhabiting upland terra firme forest, with two species and seven subspecies currently recognized. Despite numerous systematic studies, a taxonomically-dense sampled phylogeny for Willisornis is still lacking, which, combined with evidence of paraphyly and gene flow between its recognized species, underscores the uncertainty concerning species limits and evolutionary history of the genus. Here we present phylogenies and population genetic analyses, including all currently recognized Willisornis taxa, relating them to patterns of plumage variation, and reconstructing the spatiotemporal context of diversification in the genus. Our analyses have uncovered 13 independent genetic lineages in the genus, and the monophyly of all currently named taxa, which also showed robust plumage diagnoses. However, deeply coalesced genetic lineages were also found within most Willisornis taxa, for which no consistent variation in plumage was found. The diversification of the genus Willisornis is related to hydrographic and climate change cycles across Amazonia since the Plio-Pleistocene, with most genetic lineages originating in the past one million years. Based on our findings, we recommend the recognition of a total of six species in Willisornis (one of which polytypic) based on the congruency between deeply coalesced lineages and consistent plumage diagnoses.
ICRF (ion cyclotron range of frequencies) discharge cleaning with toroidal and vertical fields on EAST

Field: Physics and Astronomy (Physical Sciences)

ICRF (ion cyclotron range of frequencies) discharge cleaning with a toroidal field and an additional vertical field was carried out on EAST recently. With the injected ICRF power of 10 kW, He pressure of 10−3 Pa, toroidal field of 0.5 T and vertical field of 0.01 T, ICRF plasmas became approximately symmetric in both major radial and vertical directions, and the removal rate of hydrogen increased by 32%. A comparison of ICRF discharge cleaning between stainless steel and graphite walls was carried out, which showed that ICRF plasmas had a similar effect on the first walls of both materials. ICRF discharge cleaning between plasma shots after a major disruption was studied in detail, and it was observed that ICRF discharge cleaning under a toroidal field of 2 T was effective in recovering plasma performance quickly after a major disruption.