jimnoneill/paper-to-field-training huggingface dataset:
Induction of HSP 70 of Vascular Endothelial Cells under Oxidative Stress.

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Oxidative stress influences the pathologic development of many diseases. Vascular endothelial cells are particularly vulnerable targets for reactive oxygen. In this report, we examine the physiological changes, cell viability, induction of HSP 70 and the clotting and fibrinolytic factors of vascular endothelial cells under oxidative stress from hydrogen peroxide. Under such stress from 0.0003% to 0.003% hydrogen peroxide, the expression of HSP 70 increased 2.5-fold compared with that of the control. The production of PAI-1 of vascular endothelial cells tended to increase up to 0.003% hydrogen peroxide. The cell viability and tPA production of vascular endothelial cells decreased only once (00.001%), but then held steady (0.0010.003%). When oxidative stress exceeded 0.003% hydrogen peroxide, the induction of HSP 70, cell viability, and the tPA and PAI-1 production of vascular endothelial cells decreased.Thus, under oxidative stress, vascular endothelial cells virtually always expressed HSP 70 in response, and would be cytoprotected by induced HSP 70, and the blood clotting and fibrinolytic systems depended on coagulation. Under the excessive oxidative stress (over 0.003% hydrogen peroxide), all of them (cell viability of HUVEC, production of tPA and PAI-1 and expression of HSP 70) decreased.
Estimating Flight Characteristics of Anomalous Unidentified Aerial Vehicles

Field: Physics and Astronomy (Physical Sciences)

A number of Unidentified Aerial Phenomena (UAP) encountered by military, commercial, and civilian aircraft have been reported to be structured craft that exhibit 'impossible' flight characteristics. We consider a handful of well-documented encounters, including the 2004 encounters with the Nimitz Carrier Group off the coast of California, and estimate lower bounds on the accelerations exhibited by the craft during the observed maneuvers. Estimated accelerations range from almost 100g to 1000s of g's with no observed air disturbance, no sonic booms, and no evidence of excessive heat commensurate with even the minimal estimated energies. In accordance with observations, the estimated parameters describing the behavior of these craft are both anomalous and surprising. The extreme estimated flight characteristics reveal that these observations are either fabricated or seriously in error, or that these craft exhibit technology far more advanced than any known craft on Earth. In many cases, the number and quality of witnesses, the variety of roles they played in the encounters, and the equipment used to track and record the craft favor the latter hypothesis that these are indeed technologically advanced craft. The observed flight characteristics of these craft are consistent with the flight characteristics required for interstellar travel. That is, if these observed accelerations were sustainable in space, then these craft could easily reach relativistic speeds within a matter of minutes to hours and cover interstellar distances in a matter of days to weeks, proper time.
Organisation des Innovationsmanagements

Field: Business, Management and Accounting (Social Sciences)

Wie aber verhindert man, dass eine Idee scheitert? Was braucht es für eine Innovation? Was sind die Voraussetzungen für eine erfolgreiche Umsetzung der ersten Ideen zu Innovationen? Welche Organisation fördert Innovationen? Antworten auf diese und andere Fragen bietet dieses Kapitel.
Spectroscopic Studies and Photodynamic Actions of Hypocrellin B in Liposomes¶

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Hypocrellin B (HB), a lipid-soluble natural pigment of perylenequinone derivative, is considered as potential photosensitizer for photodynamic therapy. Liposomes loaded with HB can constitute a simple model system, appropriate for better understanding the photodynamic action of HB in vivo. The steady-state absorption and emission spectra, quantum yield and lifetime of fluorescence of HB incorporated into egg L-a-phosphatidyl-choline (EPC) liposome were examined. The photochemical properties (Type I and/or Type II) of HB have also been studied in aqueous dispersions of small unilamellar liposomes of EPC using electron paramagnetic resonance and spectrophotometric methods, respectively. The quantum yield of 1O2 generated by HB is ca 0.76 in chloroform solution and it did not change upon the incorporation of HB into liposomes of EPC. The superoxide anion radical was generated by the electron transfer from the anion radical of HB (HB.-) to oxygen. The disproportionation of O2.- can generate H2O2 and ultimately the highly reactive .OH via the Fenton reaction. It could be that the disproportionation proceeded too fast, so we could not detect O2.- directly in aqueous dispersions of liposome EPC. Moreover, the self-sensitized photooxygenation of HB embedded in liposomes was studied, and almost fully (87%) inhibiting this reaction of HB by p-benzoquinone (as the quencher of O2.-) in aqueous dispersion of liposome EPC indicated that the radical mechanism (Type I) might be mainly involved in this oxygenation. All these findings suggested that the photodynamic action of HB proceeded via both Type-I and -II mechanisms, but Type-I mechanism might play a more important role in the aqueous dispersion.
Multilateration method based on the variance of estimated distance in range‐free localisation

Field: Computer Science (Physical Sciences)

Most of the range‐free localisation techniques compute the position of a node through multilateration based on distances between nodes. The least squares estimation (LSE) based multilateration is used to determine the position of a node – which is optimal estimation method if all the variances of distance errors are equal. In range‐free localisation, the distances to the anchors are usually estimated by multiplying the hop count and the hop length. Since the estimated hop length is error prone, the distance estimation error and the error variance usually increase as the hop count increases. If the conventional multilateration algorithm, which gives the same weights to the estimated distances, is applied as it is, suboptimal result will be achieved because the variances of the distance estimation errors cannot be equal. In this Letter, we analyse the reliability of estimated distance and propose a novel LSE based multilateration which considers the reliability of estimated distance. Simulation results show that the proposed method improves performance compared with the existing methods.
StrainInfo SI-ID 408848.1

Field: Immunology and Microbiology (Life Sciences)

StrainInfo dataset 408848 about a strain of Citrobacter murliniae. StrainInfo is a service developed to provide a resolution of microbial strain identifiers by storing culture collection numbers, their relations, and culture-associated data. StrainInfo is part of NFDI4Microbiota consortium.
[Radiofrequency ablation of type I atrial flutter. Personal experience].

Field: Medicine (Health Sciences)

The cause of Afl-I is macroentry in the right atrium. The critical site of reentry is the narrow anatomical space in the isthmic region between the posterior part of the annulus of the tricuspid valve and the vena cava inferior (isthmus TA-IVC). Radiofrequency ablation (RF) of the isthmus TA-IVC is successful on average in 90% of patients. The best criterium for evaluation of short-term and long-term effect of RF ablation is a two-way block of conduction in the TA-IVC insthmus, created by RF ablation. In case of a relapse it is possible to repeat ablation. Although a proarrhythmic effect of ablation is not assumed, the cause of the higher frequency of atrial fibrillation is not known. The authors present their own experience with the treatment of Afl-I by RF ablation of the TA-IVC isthmus in a group of 18 patients. RF ablation was successful in 83.3% patients of the group, no complications were recorded. Late relapses of Afl-1 in three patients were resolved by repeated RF ablation which was successful. The results are comparable with results in other departments. Based on their own experience the authors consider ablation treatment of Afl-1 a safe and effective therapeutic method in a selected group of patients.
Retention Enema with Rhubarb Decoction in Treating Hepatic Encephalopathy:Results from a Multi-center Clinical Trial

Field: Medicine (Health Sciences)

Objective:To observe the effects of retention enema with rhubarb decoction on hepatic encephalopathy(HE) in a multi-center clinical trial.Methods:In a randomized,parallel group,controlled,multi-center trial,360 patients with HE were randomized to receive usual care alone(group C) or plus rhubarb decoction retention enema(group A) or routine enema(group B) for two 7-day courses.Changes in time to resuscitation,HE grade,number connection test(NCT),blood ammonia(NH3) and liver function test from baseline to endpoint were observed.Results:Patients in group A had significantly shorter time to resuscitation,lower NH3,improved liver function and a higher response rate of up to 86%,compared with group B and C(P0.05 and P0.01,respectively).In addition,the average medical cost for patients in group A was only 73.1% of that for group C,which represented a reduction in medical cost of 11,000 yuan per patient,a statistically significant difference(P0.01).No significant adverse events were observed across the 3 groups.Conclusion:With the potential to boost clinical efficacy while reducing medical cost,retention enema with rhubarb decoction appears to be promising for the treatment of HE.
Effectiveness of water, sanitation and hygiene-based programme on toilet etiquette and sanitation targeted at primary school children of Mumbai

Field: Health Professions (Health Sciences)

Background: As per the WHO-UNICEF monitoring report 2012, around 626 million people, or half of the population of India defecate in the open; this explains the high burden of communicable diseases in developing countries like India. In this context present study attempts to assess the effectiveness of school-based awareness programme on toilette etiquettes and sanitation in primary school-going children (mean age 9.27 years.) of Mumbai city. Methods: This is a comparative, before and after study between the interventional group and the comparison group. The study was carried out between July 2016 to March 2017, end line survey was carried out approximate 3 months after programme intervention for both the groups. Stratified random sampling was used to select 3737 students in baseline and 3230 students in end line from 130 primary schools run by municipal corporation of greater Mumbai (MCGM).Results: Knowledge and attitude significantly improved in the end line than the baseline survey exorbitantly for the interventional group than the comparison group. Although the comparison group also exhibited some improvement but there was a marked difference as when compared to the interventional group.Conclusions: An innovative education cum entertainment intervention programmes on basic health and hygiene habits focused on toilette etiquettes and sanitation was conducted. This has influenced the KAP among primary school children of Mumbai city. Though individual behaviour is difficult to mould, short to medium term effects of innovative programmes like WASH are encouraging.
Biblioteca Italiana dell’Educazione Linguistica - BELI

Field: Arts and Humanities (Social Sciences)

<div> <p>The complete bibliography, from 1960 to nowadays, can be found in the websites of the Research Centre on Language Education of Ca' Foscari University (www.unive.it/crdl), of the Laboratorio Itals (www.itals.it) and of Società Italiana di Didattica delle Lingue e Linguistica Educativa (www.dille.it). BELI is a work in progress, it is based on the collaboration of Italian scholars and all experts can suggest integrations or corrections. This is the 2014 bibliography</p> </div>
Probabilistic Interpretation of Observer Effect on Entrepreneurial Opportunity

Field: Business, Management and Accounting (Social Sciences)

Abstract Background : In quantum mechanics, the observer effect categorically states that observing a phenomenon changes it. This research explores a probabilistic interpretation of entrepreneurial opportunity and explains the observer effect reflecting on Schrödinger’s cat thought experiment. This approach addresses opportunity as a “possibility” concept reinterpreting it from multiple observers’ perspectives and the cruciality of action to cause wave function collapse to an emergent reality. This paper intends to resolve the epistemological paradox and ‘opportunity’ war by re-contextualising opportunity as an artefact and positing it as a probability wave with a range of possibilities until alert entrepreneurs act on it. Method : This conceptual development relies on literature review as a research methodology, using reasoning by analogy for the progress of theory and metaphors for theorisation. Results : This conceptual narrative strengthens the epistemological foundation focused on possibility and probability (illustrated through wave function) to sharpen the definition of opportunity and action theory. The observer effect in opportunity is underexplored in entrepreneurial scholarship. This study features how the observer effect influences the evolving state of opportunity. Opportunity is affected by other observers and the entrepreneur’s imagination, social construction and effort. Each involved agent relates and interacts to give rise to possibilities in opportunities. The interrelations and interdependence are complex, giving rise to superposition with a mixed state with many possibilities. Conclusions : The contribution of this research is manifold from a theoretical and practical level. It presents a quantum-like model where an ‘un-acted’ opportunity is in superposition (multiple possibilities emerging simultaneously until it is enacted), expanding on Ramoglou and Tsang’s (2016) view on propensity. The interactional effects – interfering and entangling between agents observing the same opportunity generate possibilities. The potentiality and the many-possibilities states in the opportunity artefact hold great promise in entrepreneurial research.
Influence of cloud retrieval errors due to three-dimensional radiative effects on calculations of broadband shortwave cloud radiative effect

Field: Physics and Astronomy (Physical Sciences)

Abstract. We investigate how cloud retrieval errors due to the three-dimensional (3D) radiative effects affect broadband shortwave (SW) cloud radiative effects (CREs) in shallow cumulus clouds. A framework based on the combination of large eddy simulations (LESs) and radiative transfer (RT) models was developed to simulate both one-dimensional (1D) and 3D radiance, as well as SW broadband fluxes. Results show that the broadband SW fluxes reflected at top of the domain, transmitted at the surface, and absorbed in the atmosphere, computed from the cloud retrievals using 1D RT (F1D∗), can provide reasonable broadband radiative energy estimates in comparison with those derived from the true cloud fields using 1D RT (F1D). The difference between these 1D-RT-simulated fluxes (F1D∗, F1D) and the benchmark 3D RT simulations computed from the true cloud field (F3D) depends primarily on the horizontal transport of photons in 3D RT, whose characteristics vary with the sun's geometry. When the solar zenith angle (SZA) is 5°, the domain-averaged F1D∗ values are in excellent agreement with the F3D, all within 7 % relative CRE bias. When the SZA is 60°, the CRE differences between calculations from F1D∗ and F3D are determined by how the cloud side-brightening and darkening effects offset each other in the radiance, retrieval, and broadband fluxes. This study suggests that although the cloud property retrievals based on the 1D RT theory may be biased due to the 3D radiative effects, they still provide CRE estimates that are comparable to or better than CREs calculated from the true cloud properties using 1D RT.
New Data on the Stomiid Teleost Bathophilus nigerrimus from Mediterranean Waters

Field: Agricultural and Biological Sciences (Life Sciences)

In this paper new data on the scaleless dragonfish Bathophilus nigerrimus Giglioli 1882 (Stomiidae) are provided. We examined an individual found stranded on the shore of the Sicilian coast of the Strait of Messina on February 2, 2019. Additional data were retrieved by two more specimens from the same study area: from the first one, found stranded on March 1992, morphometric and meristic data were taken, and from the second, collected in good condition from a stomach of the carangid Trachurus picturatus, microincrement counts from otolith were performed. We also used data from bibliography to reconstruct the relationship between total (TL) and standard length (SL) for this species. The comparison between our data and the counts of meristic characters in previous records reveals that the number of pectoral fin rays is quite variable, due to the bad condition of some preserved specimens or damages from trawling. The analysis of the stomach content allowed to observe that a large prey (Diaphus holti; 78.89% of predator size) was present, suggesting that B. nigerrimus may base its feeding strategy on the consumption of large meals (e.g. other meso- and bathy-pelagic teleosts), to obtain an energetic advantage in deep waters. For the first time, the analysis of otolith microstructure allowed to count 231 and 168 microincrements in the examined individuals (54 and 37 mm SL, respectively). The new data reported in the present paper can be considered a step forward in the understanding of the biology and ecology of B. nigerrimus.
Swt21p Is Required for Nam8p-U1 snRNP Association and Efficient Pre-mRNA Splicing in Saccharomyces cerevisiae

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

While the U1 small nuclear ribonucleoprotein (snRNP) plays a crucial role in early spliceosome assembly, the mechanisms by which it coordinates with other splicing factors for efficient assembly remain elusive. This study aimed to examine the role of the Swt21 protein in regulating U1 snRNP in Saccharomyces cerevisiae. Swt21p was required for efficient pre-mRNA splicing both in vivo and in vitro. Deletion of SWT21 altered the splicing patterns of two-intron SUS1 RNA, causing intron retention and exon skipping. Spliceosome assembly analysis revealed that in the pre-B complex, the levels of U1 protein components, as well as U1 RNA, were decreased following SWT21 deletion, highlighting the compromised stability of U1 snRNP during this stage. Consistently, in the absence of Swt21p, free isoform of U1 component Nam8p was observed, and its proper nuclear localization was disrupted, demonstrating the functional importance of Swp21p for the stable association of Nam8p with U1 snRNP. Moreover, Swt21p remained primarily in a free state under physiological conditions and did not associate with the pre-B complex. Additionally, TAP analysis revealed that Swt21p-associated proteins are involved in cellular processes beyond splicing. These findings collectively indicate that Swt21p functions as a spliceosome regulator rather than a core component and support a model wherein Swt21p contributes to U1 snRNP stability during early spliceosome assembly.
Evaluation of Records from Driving Dynamics Testing on Training Polygons

Field: Engineering (Physical Sciences)

The paper briefly informs about the content, procedures and objectives of the student grant competition project (ID No. SP2021/58) entitled “Verification of driving characteristics of water tender type firefighting vehicles” (Šudrychová et al., 2022). It summarizes the results of one of the two main project objectives, namely the evaluation of records from driving dynamics testing on training polygons under emergency braking when driving in a straight line and in a circle at a speed approaching the vehicle rollover safe limit. These two tasks are essential driving skills and must be reliably mastered by firefighting vehicle drivers in critical situations on the road.
The control of arbitrary size networks of linear systems via graphon limits: An initial investigation

Field: Mathematics (Physical Sciences)

To achieve control objectives for extremely complex and very large scale networks using standard methods is a challenging, if not intractable, task. In this paper, we propose a novel way to approximately control network systems which lie in a sequence with a well defined limit by the use of graphon theory and the theory of infinite dimensional systems. The general controllability problem is analyzed for the infinite system and then the control performance in terms of the upper bound for the L 2 state error between the limit system and the sequence of network systems is given. Finally, an example of the application of the minimum energy control methodology for network systems with sampled weightings is demonstrated.
RESEARCH ARTICLE Cumulative Effect and Predictive Value of Genetic Variants Associated with Type 2 Diabetes in Han Chinese: A Case-Control Study

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Background Genome-wide association studies (GWAS) have identified dozens of single nucleotide poly-morphisms (SNPs) associated with type 2 diabetes risk. We have previously confirmed the associations of genetic variants in HHEX, CDKAL1, VEGFA and FTO with type 2 diabetes in Han Chinese. However, the cumulative effect and predictive value of these GWAS identified SNPs on the risk of type 2 diabetes in Han Chinese are largely unknown. Methodology/Principal Findings We conducted a two-stage case-control study consisting of 2,925 cases and 3,281controls to examine the association of 30 SNPs identified by GWAS with type 2 diabetes in Han Chi-nese. Significant associations were found for proxy SNPs at KCNQ1 [odds ratio (OR) = 1.41, P = 9.91 × 10–16 for rs2237897], CDKN2A/CDKN2B (OR = 1.30, P = 1.34 × 10–10 for rs10811661), CENTD2 (OR = 1.28, P = 9.88 × 10-4 for rs1552224) and SLC30A8 (OR = 1.19, P = 1.43 × 10-5 for rs13266634). We further evaluated the cumulative effect on type 2 diabetes of these 4 SNPs, in combination with 5 SNPs at HHEX, CDKAL1, VEGFA and
Density and coverage of seagrass at Tunggul Beach, Paciran, Lamongan, East Java

Field: Agricultural and Biological Sciences (Life Sciences)

Seagrass is an ecosystem that has an important role as nursery and spawning ground in the life cycle in the sea. Increased human activity and climate change are feared to damage seagrass ecosystems so it is important to maintain their sustainability. This study aims to find out the composition of species, density and coverage of seagrass at Tunggul Beach, Paciran, Lamongan. This research was conducted on August until October 2020 by applying purposive sampling method as the basis for determining location point at 2 stations, with 3 substations at each station with transect line along 100 m. Seagrass data retrieval method using transect quadrant 50 x 50 cm to observe the coverage and calculate seagrass stand. The results showed the type of seagrass found on Tunggul Beach are two species, Thalassia hemprichii and Enhalus acroides. Seagrass density value at station 1 is rather tight with a density value of 92.48% and at station 2 is rare with a value of 73.09%. The percentage of seagrass coverage at station 1 indicates a solid category with a coverage value of 54.92% and in the station 2 shows a medium coverage category with a value of 31.25%.