jimnoneill/paper-to-field-training huggingface dataset:
Protein misfolding, amyotrophic lateral sclerosis and guanabenz: protocol for a phase II RCT with futility design (ProMISe trial)

Field: Medicine (Health Sciences)

Introduction Recent studies suggest that endoplasmic reticulum stress may play a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS) through an altered regulation of the proteostasis, the cellular pathway-balancing protein synthesis and degradation. A key mechanism is thought to be the dephosphorylation of eIF2α, a factor involved in the initiation of protein translation. Guanabenz is an alpha-2-adrenergic receptor agonist safely used in past to treat mild hypertension and is now an orphan drug. A pharmacological action recently discovered is its ability to modulate the synthesis of proteins by the activation of translational factors preventing misfolded protein accumulation and endoplasmic reticulum overload. Guanabenz proved to rescue motoneurons from misfolding protein stress both in in vitro and in vivo ALS models, making it a potential disease-modifying drug in patients. It is conceivable investigating whether its neuroprotective effects based on the inhibition of eIF2α dephosphorylation can change the progression of ALS. Methods and analyses Protocolised Management In Sepsis is a multicentre, randomised, double-blind, placebo-controlled phase II clinical trial with futility design. We will investigate clinical outcomes, safety, tolerability and biomarkers of neurodegeneration in patients with ALS treated with guanabenz or riluzole alone for 6 months. The primary aim is to test if guanabenz can reduce the proportion of patients progressed to a higher stage of disease at 6 months compared with their baseline stage as measured by the ALS Milano-Torino Staging (ALS-MITOS) system and to the placebo group. Secondary aims are safety, tolerability and change in at least one biomarker of neurodegeneration in the guanabenz arm compared with the placebo group. Findings will provide reliable data on the likelihood that guanabenz can slow the course of ALS in a phase III trial. Ethics and dissemination The study protocol was approved by the Ethics Committee of IRCCS ‘Carlo Besta Foundation’ of Milan (Eudract no. 2014-005367-32 Pre-results) based on the Helsinki declaration.
[Local permanent intraarterial antimicrobic therapy in postoperative period at the patients with cholangitis].

Field: Medicine (Health Sciences)

Method of local permanent intraarterial antimicrobic therapy was used in postoperative period at the patients with acute cholangitis. The method includes transfemoral catheterization of hepatic artery and permanent infusion of ceftriabol (2.0 ml per day) and metronidazol (1.0 ml per day) during 5-7 days. At the end of first week the more positive results were achieved compared with control group.
The State of Women in Police in India and the Discrimination Faced By Them

Field: Social Sciences (Social Sciences)

Women Police have now become an integral part of the police reforms in almost all countries of the world, including India .However, the current situation of women in policing is a development of specific historical circumstances .The situation of women police with regards to their status, function, role and the obstacles they face during their job. The study seeks to look at the Gender Issue in the Police by understanding the role and perception of the police by the women employed as police, by the men who work along with these women police and by the public/society in general and hence understanding gender issues from the women’s perspective, men’s perspective and by the society’s perspective by taking a sample of 25 female (Police Gazzetted and Non Gazzetted officers), 20 male officers and 20 public members. The study also aims at understanding the women police from a sociological point of view by looking at their backgrounds, intent to join the police force and their perception of the current state of women in police The method used is the questionnaire method followed by interview of the candidates. The results show that there is a prevailing gender bias against the women with regards to their job, status, function and role and the bias exists in the perception of the female officers, male officers as well as the society .The study also make recommendations to overcome this gender difference.
Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Glycogen phosphorylase (GP) is an essential enzyme for glycolysis via the glycogen degradation pathway. It consists of three isoforms: PYGB (brain form), PYGL (liver form) and PYGM (muscle form). Although the abnormal expression of GP is associated with a variety of tumors, its relationship with hepatocellular carcinoma (HCC) and whether it can be used as a prognostic marker of HCC remains unclear. In the present study, the expression levels of PYGB, PYGL and PYGM were analyzed. It was found that the expression levels of PYGB in tumor tissues were higher than those in normal tissues, particularly in HCC. The high expression of PYGB (hazard ratios=1.801; 95% confidence interval: 1.266-2.562) could predict the poor prognosis of HCC patients but not PYGL and PYGM. Inhibition of PYGB with GP inhibitor CP91149 significantly suppressed the HCC cell proliferation in the HCC cell model. In addition, combination treatment with sorafenib, a standard treatment for HCC, showed a great inhibition on tumor growth and angiogenesis. These findings suggested that PYGB may be used as a therapeutic and prognostic indicator for HCC.
56: Substance P-Induced Expression of CD74 (Receptor for Macrophage Migration Inhibitory Factor) on the cell Surface of Urothelial cells in vivo

Field: Medicine (Health Sciences)

You have accessJournal of UrologyPodium 2, Saturday, May 19, 2007 1:00 - 3:00 pm1 Apr 200756: Substance P-Induced Expression of CD74 (Receptor for Macrophage Migration Inhibitory Factor) on the cell Surface of Urothelial cells in vivo Katherine L. Meyer-Siegler, and Pedro L. Vera Katherine L. Meyer-SieglerKatherine L. Meyer-Siegler More articles by this author , and Pedro L. VeraPedro L. Vera More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30321-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "56: Substance P-Induced Expression of CD74 (Receptor for Macrophage Migration Inhibitory Factor) on the cell Surface of Urothelial cells in vivo." The Journal of Urology, 177(4S), p. 19 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 19 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Katherine L. Meyer-Siegler More articles by this author Pedro L. Vera More articles by this author Expand All Advertisement PDF DownloadLoading ...
Transition Programs for Students with Disabilities

Field: Social Sciences (Social Sciences)

Students with disabilities are being underserved in the area of transition skill development and growth, leading to lower adult employment rates. These students need a quality education that includes developing skills that will assist them in their life after high school. There are transition programs in place to assist in resume building, job coaching, job seeking, and other skills necessary to being a productive member of the workforce. Due to a number of factors, including lack of knowledge of programs and their services, transition programs are not always accessed by those who qualify for program services. \nIn a district of over 2,500 students, it can be overwhelming to keep abreast of all of the programs the district has to offer. The purpose of this project was to increase the accessibility and knowledge of an already existing and successful transition program within the researcher???s school district by designing informational brochures for families, educators, and site administrators. These brochures were not designed to provide detailed information, but rather to offer a basic understanding of this free service. The parent and student brochure was designed to entice families and students to consider transition services. The teacher brochure was designed to increase colleague participation in this district program, as they are the ones who work with the students and know who could benefit from participation. The site administration brochure was designed to increase program knowledge among the administration team on district campuses.
A Fair and Forward Union: Black Teachers and The Chicago Teachers Union 1963 – 1987

Field: Social Sciences (Social Sciences)

This study documents the transformation of the Chicago Teachers Union by black teachers and the collective bargaining battles with the Chicago Board of Education by combining archival research and the oral histories of black teachers who were themselves teachers during the late 1960s into the 1980s. Combined with the documentary research, these black teacher voices provide valuable insights into how black teachers experienced major policy initiatives of the Board of Education and the union, such as the Board’s efforts to comply with desegregation mandates of the federal government through teacher transfer, as well as the seven teacher strikes between 1969 and 1987. In Chicago, black teachers during the period 1963-1987 were at the center of a demographic transformation in which they would by 1984 overtake white teachers as the largest racial demographic in the city’s teaching force. That demographic transformation was at the center of black teachers increasingly fighting for equal rights in the Chicago Public Schools and the Chicago Teachers Union. Black teachers by the 1980s were not only the largest racial group in the city but were also the political power bloc at the heart of successive strikes that would improve pay and benefits for teachers as well as lead to an increased focus on professional growth for teachers and contribute to the larger reform agenda of the Board of Education. Finally, this study argues that the elevation of Jacqueline Vaughn, as the union’s first African-American president, led to increased focus on professional development for teachers and a focus on reform that was absent from the previous agendas of union leadership.
Egg Yolk Peptide Stimulated Osteogenic Gene Expression

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Postmenopausal osteoporosis is characterized by low bone density which leads to increased bone fragility and greater susceptibility to fracture. Current treatments for osteoporosis are dominated by drugs that inhibit bone resorption although they also suppress bone formation that may contribute to pathogenesis of osteonecrosis. To restore the extensive bone loss, there is a great need for anabolic treatments that induce osteoblasts to build new bone. Pre-osteoblastic cells produce proteins of the extra-cellular matrix, including type I collagen at first, and then to successively produce alkaline phosphatase (ALP) and osteocalcin during differentiation to osteoblasts. Finally, osteoblasts deposit calcium. Present study investigated the effects of egg yolk peptide (EYP) on osteogenic activities and bone matrix gene expressions in human osteoblastic MG-63 cells. The effects of EYP on cell proliferation, alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization were measured. The expression of osteogenic genes including COL1A1 (collagen, type I, alpha 1), ALP, BGLAP (osteocalcin), and SPP1 (secreted phosphoprotein 1, osteopontin) were measured by quantitative realtime PCR. EYP dose-dependently increased MG-63 cell proliferation, ALP activity, collagen synthesis, and calcium deposition. Furthermore, COL1A1, ALP, and SPP1 gene expressions were increased by EYP treatment. Present study suggested that EYP treatment enhanced osteogenic activities and increased bone matrix osteogenicgenes. These results could provide a mechanistic explanation for the bone-strengthening effects of EYP.
An Empirical Study of the Trade between China and Middle East European based on Gravity Model

Field: Economics, Econometrics and Finance (Social Sciences)

Through systematic analysis of current situations and main influencing factors of trade between China and Middle East European,this paper uses panel data and builts three gravity models to prove that economic scale has a significant promotion effect on China and Middle East Europe trade,while promotion effect of scale of population is not significant;geographical distance is not conducive to trade expansion between China and Middle East Europe,and the eastward expansion of the European Union is in favor of trade expansion between China and Middle East Europe.Studies also show that trade between China and Middle East Europe is off Linder demand theory of similarity.Finally,based on the gravity model this paper makes estimation of trade potential and cooperation between China and Middle East Europe which is importing more products from Middle Eastern Europe and expanding the scope of cooperation.
The Hindu Trade Union Movement in India: The Bharatiya Mazdoor Sangh

Field: Social Sciences (Social Sciences)

Research Article| July 01 1993 The Hindu Trade Union Movement in India: The Bharatiya Mazdoor Sangh Kiran Saxena Kiran Saxena Search for other works by this author on: This Site PubMed Google Scholar Asian Survey (1993) 33 (7): 685–696. https://doi.org/10.2307/2645356 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Kiran Saxena; The Hindu Trade Union Movement in India: The Bharatiya Mazdoor Sangh. Asian Survey 1 July 1993; 33 (7): 685–696. doi: https://doi.org/10.2307/2645356 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAsian Survey Search This content is only available via PDF. Copyright 1993 The Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.
Surveillance of Ochratoxin A in cocoa beans from cocoa-growing regions of Ghana

Field: Agricultural and Biological Sciences (Life Sciences)

Objectives: Cocoa is one of the agricultural commodities which is highly susceptible to mycotoxin contamination. The present study surveyed the incidence and distribution of ochratoxin A (OTA) in cocoa beans over two crop seasons. Materials and Methods: The cocoa beans samples were collected randomly from farmers across cocoa-growing regions of Ghana. OTA concentrations in the samples were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods following purification on immunoaffinity solid phase column. Results: The result showed that 21.7% of all samples analyzed were contaminated with OTA at concentrations ranging from 0.01 g/kg to 12.36 g/kg. However, 0.9% and 3.5% of the OTA-positive samples exceeded the OTA maximum limits of 10 g/kg for cocoa beans and 3 g/kg for cocoa powder, set by the Brazilian National Health Surveillance Agency and the European Commission, respectively. During the main and light crop seasons, the highest concentrations of OTA were detected in the Western North region, reaching up to 12.36 g/kg and 3.45 g/kg, respectively. OTA concentrations between the cocoa-growing regions in the main crop season were not significantly different (p > 0.05), however, the light crop season indicated a significant difference (p < 0.05). There was a significant difference (p < 0.05) between the two crop seasons. Conclusions: The need for regular monitoring and careful adherence to agronomic strategies such as good agricultural practices (GAPs), recommended code of practices (COPs) and good manufacturing practices (GMPs) for the prevention and reduction of OTA throughout the cocoa value chain cannot be over emphasized.
An Efficient Methodology Based on Coverage Area to Modify Location and Power Ratings of Distribution Transformers

Field: Engineering (Physical Sciences)

The Technology development and rising standards of living are increasing the demand for electricity in city centres. In addition, the density of electric power in different areas of a city changes with the construction of new residential areas. Variation in load density can be managed by adjusting the voltage on distribution lines, installing new lines and transformer centres, and reconfiguring existing lines and transformer centres. In this study, the Istanbul Uskudar District of Kanlica-Cubuklu Region was examined and coverage areas were modified depending on the load density and power of the existing transformers. A novel systematic approach to determine the coverage area of transformers is presented. In this approach, the coverage area and overlap of each transformer with its neighbours were determined. Subsequently, transformers that are under-used or have significant overlap with neighbouring transformers were removed from the network. The transformers were placed into an optimal structure in the network by distributing the load of an excluded transformer to its nearest neighbours. This approach further allows the minimum route for the high voltage distribution wiring between transformers and cost to be determined.
"Florida style gardening"-an educational series for new residents

Field: Agricultural and Biological Sciences (Life Sciences)

A large percentage (81%) of the residents in Pinellas County have moved into from other states. They bring with them preconceived ideas about gardening that may not be applicable to the growing conditions in their new location. This can lead to frustration about gardening in Florida. Florida Style Gardening is an 18-hour educational program targeting these new residents with information about the soils, growing conditions, growing seasons, and environmental landscape considerations specific to the Tampa Bay area. This series has been offered twice, 2004 and 2005. A survey of participants reveals changes in attitudes about gardening and changes in behavior regarding water usage, fertilization, pesticide usage and the use of mulch.
Potential role of novel hepatocellular carcinoma-associated gene IDD01 in promoting tumorigenesis of HepG2 cell line

Field: Medicine (Health Sciences)

我们使用了的背景抑制构造 hepatocellular 癌(HCC ) 的一个减去的 cDNA 图书馆的减少性的杂交并且孤立微分表示顺序标签(EST ) 的一块面板。由使用生物信息学和 cDNA 结束(种族) 的快速的扩大，我们发现一篇小说联系 HCC 的基因 IDD01。为了推进，调查它的功能， recombinanteukaryotic 向量 pEGFP/ORF 被构造并且 transfected 进 HepG2 房间线。IDD01 的方法 Theopen 读物框架(ORF ) 被 RT-PCR 放大，与 Bamh 消化了Ⅰ和后部的Ⅲ， andsubcloned 进 pEGFP-C1 向量。结扎反应与 T4 DNA ligase 被进行，并且 therecombinant 向量被称为 pEGFP/ORF。Untransfer 控制(控制组) ， pEGFP-C1 (HepG2/C1group ) 和转移组织的 pEGFP/ORF (HepG2/ORF 组) 被设计。基因转移与 lipofectamine 被进行。在 HepG2 房间获得稳定的 transfection，选择与 500 μ g /ml G418 被开始。细胞的 IDD01 mRNA 层次是由半量的 RT-PCR 的 assayed。MTTcolorimetric 方法和流动 cytometry 被用来决定房间增长。转变房间的 Thetumorigenic 潜力从他们在软琼脂上种 asanchorage 独立的殖民地的能力被决定。短暂 transfections 被执行到 GFP-IDD01 熔化蛋白质的 observesubcellular 地点。结果 A 778 bp ORF 的特定的乐队被 RT-PCR，和 recombinant 原生质标志 pEGFP/ORF (5.5 Kb ) 的积极克隆获得被限制 endonuclease 劈开和顺序识别。IDD01 mRNA 的亮度比率不在控制和 pEGFP/C1 组之间是明显的，而 pEGFP/ORF 的比率在另外的二个组比那高。在为 24-72 小时的文化以后，在 pEGFP/ORF 的 A_(490 ) 价值比在另外的二个组的那些高(P < 0.01 ) 。在流动 cytometry 的直方图上， S 阶段比率 ofHepG2/ORF 房间比控制和 HepG2/C1 组的显著地高。HepG2/ORFcells 能与另外的 HepG2 房间线相比在软琼脂形成更多的殖民地(P < 0.01 ) 在血浆主要局部性的 .GFP-IDDOl 熔化蛋白质，而 EGFP 蛋白质扩散了布满全面房间。DDD01 基因是在房间增长的一个积极受动器
Stack testing of the mobile plasma arc unit

Field: Environmental Science (Physical Sciences)

A trial-burn program involving a plasma-pyrolysis system was conducted at the Royal Military College, Kingston, Ontario. The plasma-pyrolysis unit was developed by Pyrolysis Systems, Inc. under contract to the New York State Department of Environmental Conservation (NYSDEC). HWERL-Ci under a joint agreement funded the performance evaluation phase. Trial burns were conducted while firing carbon tetrachloride and polychlorinated biphenyls which are RCRA and TSCA regulated compounds, respectively. Results from the trial burns indicate that the system is acceptable for treating these two compound classes in reference to the RCRA ( > or = 99.99% DRE) and TSCA ( > or = 99.9999% DRE) requirements.
Red Cell Distribution Width as a Predictor of Severity of Acute Pancreatitis

Field: Medicine (Health Sciences)

Introduction: Acute pancreatitis (AP) is a disorder featured by local and systemic inflammatory response, which manifests as mild, self-limited disorder to severe and sometimes fatal disease. Red cell distribution width (RDW) is reflective of systemic inflammation and has been shown to be effective at predicting severity. This study was aimed to investigate the association between Red cell distribution width as coefficient of variation (RDW -CV) on admission and severity of acute pancreatitis. Method: This was a hospital based prospective study conducted in the Department of Surgery, Nepalgunj Medical College Teaching Hospital for a period of 2 years from July 2017 to June 2019. The patients with acute pancreatitis were categorized into mild, moderate and severe acute pancreatitis. The value of RDW-CV on admission was correlated with the severity of acute pancreatitis. Results: RDW-CV on admission was significantly correlated with the severity of AP (p value <0.001). Receiver Operating Characterstic (ROC) analysis showed that RDW has very good discriminative power for severe acute pancreatitis [AreaUnder curve (AUC) 0.963, 95% CI, 0.919 to 1.007, p-value <0.001] but not useful to predict mild AP (AUC 0.157, 95% CI, 0.063 to 0.250, p value 0.14) and moderate AP (AUC 0.397, 95% CI, 0.252 to 0.541, p value 0.234). The maximum sensitivity and specificity of detecting severe AP was 95.7% and 91.5% respectively. The positive predictive value (PPV) and negative predictive value (NPV) was 84.6% and 97.7% respectively. Conclusion: RDW-CV width on admission is a predictor of severity in patients with severe acute pancreatitis.
Contemplating, caring, coping, conversing: a model for promoting mental wellness in later life.

Field: Health Professions (Health Sciences)

This article is based on the premise that mental wellness for older adults can be promoted through communication and presents a model drawing on the constructs of contemplating, caring, coping, and conversing. The importance of interpersonal communication processes in the care of older adults and some barriers to communication and mental wellness are briefly reviewed. This article challenges nurses to develop awareness of their own caregiving styles and communication processes, and to assist others (e.g., family caregivers, care receivers) to communicate and interact more effectively to advance mental wellness for older adults.
SignSense - Enhancing Road Safety through Convolutional Neural Networks

Field: Computer Science (Physical Sciences)

This project focuses on the critical area of enhancing road safety through Convolutional Neural Networks.In a world dominated by technological advancements, the need for intelligent transportation systems is paramount.The project employs cutting-edge techniques in the realms of Artificial Intelligence and Machine Learning to develop a robust system capable of accurately detecting and classifying traffic signs.The proposed solution leverages deep learning algorithms, particularly Convolutional Neural Networks (CNNs), to enhance the efficiency and accuracy of traffic sign recognition.Through a comprehensive dataset and meticulous model training, the system achieves high-performance levels, contributing to enhanced road safety and improved traffic management.The project not only addresses the technical intricacies of the AI&ML domain but also underscores its practical applications in real-world scenarios, aligning with the broader goals of creating smarter and safer urban environments.