jimnoneill/paper-to-field-training huggingface dataset:
Surgery, Octreotide, Temozolomide, Bevacizumab, Radiotherapy, and Pegvisomant Treatment of an AIP Mutation‒Positive Child

Field: Medicine (Health Sciences)

Abstract Context Inactivating germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene are linked to pituitary adenoma predisposition. Here, we present the youngest known patient with AIP-related pituitary adenoma. Case Description The patient presented at the age of 4 years with pituitary apoplexy and left ptosis with severe visual loss following a 1-year history of abdominal pain, headaches, and rapid growth. His IGF-1 level was 5× the upper limit of normal, and his random GH level was 1200 ng/mL. MRI showed a 43 × 24 × 35‒mm adenoma with suprasellar extension invading the left cavernous sinus (Knosp grade 4). After transsphenoidal surgery, histology showed a grade 2A sparsely granulated somatotropinoma with negative O6-methylguanine-DNA methyltransferase and positive vascular endothelial growth factor staining. Genetic testing identified a heterozygous germline nonsense AIP mutation (p.Arg81Ter). Exome sequencing of the tumor revealed that it had lost the entire maternal chromosome-11, rendering it hemizygous for chromosome-11 and therefore lacking functional copies of AIP in the tumor. He was started on octreotide, but because the tumor rapidly regrew and IGF-1 levels were unchanged, temozolomide was initiated, and intensity-modulated radiotherapy was administered 5 months after surgery. Two months later, bevacizumab was added, resulting in excellent tumor response. Although these treatments stabilized tumor growth over 4 years, IGF-1 was normalized only after pegvisomant treatment, although access to this medication was intermittent. At 3.5 years of follow-up, gamma knife treatment was administered, and pegvisomant dose increase was indicated. Conclusion Multimodal treatment with surgery, long-acting octreotide, radiotherapy, temozolomide, bevacizumab, and pegvisomant can control genetically driven, aggressive, childhood-onset somatotropinomas.
ADDITIONAL EFFECTS OF KINESIOTAPING TO MOBILIZATION TECHNIQUES IN CHRONIC MECHANICAL NECK PAIN

Field: Health Professions (Health Sciences)

Objectives: The aim of this study was to investigate the additional e ects of kinesio taping to mobilization techniques on muscle activation of deep cervical exors and neck pain in chronic mechanical neck pain. Methods: Twenty-eight participants with mechanical neck pain were included in this study. The participants were randomized into two groups: mobilization group (Group 1) and kinesio taping group (Group 2). Treatment for Group 1 (Mean age: 25.71±8.39 yrs) included scapular mobilization, ischemic compression for trigger points and Cyriax mobilization techniques for cervical region. Treatment for Group 2 (Mean age: 30.29±12.92 yrs) included kinesio taping, additionally. Head and neck pain were assessed by Visual Analog Scale, while the muscle activation of deep neck cervical exors was assessed by Craniocervical Flexion Test, using “Stabilizer Pressure Biofeedback” device before treatment and four days a er treatment. Inter-group di erences were analyzed by Mann Whitney U Test, and intra-group changes were analyzed by Wilcoxon Test. Also the e ect sizes of intra-group changes were analyzed. Results: There was no significant di erence between the groups for any outcome (p&amp;gt;0.05). Endurance of deep cervical exors improved (Group 1, p=0.018; Group 2, p=0.004), and inten- sity of headache reduced significantly, in both groups (Group 1, p=0.038; Group 2, p&amp;lt;0.001). E ect sizes of changes in activation of deep cervical exor muscles were d: 0.68 and d: 0.863 in Group 1 and 2, respectively. E ect sizes of changes in headache intensity were d: 0.86 and 0.83 in Group 1 and 2, respectively. Conclusions: When e ect size di erences were analyzed, it was considered that kinesio taping could be used in addition to mobilization techniques in the treatment of mechanical neck pain.
Using Training Evaluation to Improve Practice

Field: Health Professions (Health Sciences)

By providing you with a detailed description of our upgrade training case, we hope you would be able to (a) relate and compare our case descriptions, environment, processes to your organization and environment, (b) Identify similarities and difference between our cases, and (c) Develop possible action plan based on our lesson learn to carry out your training and evaluations needs. In our lesson learned, look for tools that work best for you depending on your environment to conduct training and evaluations (Beebe et al., 2012). Locate or create your training and evaluation data because they are very useful in improving your training for your learners (Phillips, 1997). Following-up extreme feedback after training evaluation (Goad, 2010) either directly in person or through related channel allows you to evaluate and gain more insight into learner's reactions.
Penerapan Finger Painting dalam Mengembangkan Aspek Perkembangan Motorik Halus Anak Kelas A di Taman Kanak Islam Terpadu Ya Bunayya Sambas

Field: Social Sciences (Social Sciences)

The application of Finger Painting to develop fine motor development in class A children at TKIT Ya Bunayya Sambas is a study that reveals clear information about: 1). How is the implementation of finger painting to develop fine motor development in class A children at TKIT Ya Bunayya Sambas, 2). The results of implementing finger painting to develop fine motor development in class A children at TKIT Ya Bunayya Sambas 3). Supporting factors inhibiting the implementation of finger painting to develop fine motor development in class A children at TKIT Ya Bunayya Sambas. This study uses a qualitative approach to the type of phenomenological research. Data collection techniques using observation, interviews, and documentation. While the data analysis techniques consist of data reduction, data display, data verification and conclusions. The data sources are educators, principals and students. The research results show that; 1. Implementation of finger painting to develop fine motor development in class A children at TKIT Ya Bunayya Sambas is carried out by prior preparation by making RPPH (daily learning implementation plan), providing tools and materials in the form of paper, finger painting dough, coloring, tissues, 2. The results of the implementation of finger painting to develop fine motor development in class A children at TKIT Ya Bunayya Sambas show that fine motor development is developing very well (BSB) as evidenced by the child's fingers becoming more flexible in coloring using colored pencils and being able to make pattern in the picture, 3. Factors supporting finger painting to develop fine motor development in class A children at TKIT Ya Bunayya Sambas namely good motivation and enthusiasm for children, good environment from family and school, attention and stimulus that supports children's fine motor development , there are sufficient facilities for an children and good nutrition and health for children and the inhibiting factor is the lack of enthusiasm or mood of some students due to illness.
Migration as a Factor in Pest-outbreaks

Field: Agricultural and Biological Sciences (Life Sciences)

Human experience in the past has often been crystallized into homely saws, of which the one that states that “ Prevention is better than cure ” should be regarded as one of the foundation stones of all work in economic entomology. We see this put into practice in such routine measures as the destruction of mosquito and fly larvae, ploughing fields in the dry weather to destroy grasshopper egg-masses, the destruction of weeds and stubble, the collection of egg-masses, caterpillars and hoppers, the enforced removal of cotton-plants after harvest, legislation against the introduction of pests into new countries, and similar measures which are so familiar that they need not be enlarged on here. Such measures are directed to and, if applied consistently, are largely effective in keeping within bounds insects which, if not thus checked, normally attain to destructive numbers, and by “ normally ” I mean that on the average they occur in such numbers every year, or for a series of years. There are, of course, fluctuations, due to natural causes, in the pest-status of many insects, which may be insignificant in normal years and occasionally rank as bad pests, or vice versa ; of such causes we know as yet very little, beyond the pious ascription of them to the effects of parasitic control or climate. But, after eliminating these fluctuations, we still often find our expectations upset by outbreaks for which it is very difficult to invoke any adequate explanation other than that they are the effect of a large influx into the area affected of the insect concerned. Such a theory may appear far-fetched at first sight, especially as it is very difficult of proof in most cases, but we find in India an accumulation of cases for which such an explanation seems the only one possible.
Depressive Symptoms and Incident Heart Failure in the Jackson Heart Study: Differential Risk Among Black Men and Women

Field: Medicine (Health Sciences)

Background Associations between depression, incident heart failure (HF), and mortality are well documented in predominately White samples. Yet, there are sparse data from racial minorities, including those who are women, and depression is underrecognized and undertreated in the Black population. Thus, we examined associations between baseline depressive symptoms, incident HF, and all‐cause mortality across 10 years. Methods and Results We included Jackson Heart Study (JHS) participants with no history of HF at baseline (n=2651; 63.9% women; median age, 53 years). Cox proportional hazards models tested if the risk of incident HF or mortality differed by clinically significant depressive symptoms at baseline (Center for Epidemiological Studies–Depression scores ≥16 versus <16). Models were conducted in the full sample and by sex, with hierarchical adjustment for demographics, HF risk factors, and lifestyle factors. Overall, 538 adults (20.3%) reported high depressive symptoms (71.0% were women), and there were 181 cases of HF (cumulative incidence, 0.06%). In the unadjusted model, individuals with high depressive symptoms had a 43% greater risk of HF ( P =0.035). The association remained with demographic and HF risk factors but was attenuated by lifestyle factors. All‐cause mortality was similar regardless of depressive symptoms. By sex, the unadjusted association between depressive symptoms and HF remained for women only ( P =0.039). The fully adjusted model showed a 53% greater risk of HF for women with high depressive symptoms ( P =0.043). Conclusions Among Black adults, there were sex‐specific associations between depressive symptoms and incident HF, with greater risk among women. Sex‐specific management of depression may be needed to improve cardiovascular outcomes.
Identification and characterization of a sex peptide receptor‐like transcript from the western tarnished plant bug L ygus hesperus

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract Lygus hesperus females exhibit a post‐mating behavioural switch that triggers increased egg laying and decreased sexual interest. In D rosophila melanogaster , these changes are controlled by sex peptide ( SP ) and the sex peptide receptor ( DmSPR ). In H elicoverpa armigera , SPR ( HaSPR ) also regulates some post‐mating behaviour; however, myoinhibiting peptides ( MIPs ) have been identified as the SPR ancestral ligand, indicating that SPR is a pleiotropic receptor. In the present study, we identified a transcript, designated L . hesperus SPR ( LhSPR ), that is homologous to known SPRs and which is expressed throughout development and in most adult tissues. Lh SPR was most abundant in female seminal depositories and heads as well as the hindgut/midgut of both sexes. In vitro analyses revealed that fluorescent chimeras of LhSPR , DmSPR and HaSPR localized to the cell surface of cultured insect cells, but only DmSPR and HaSPR bound carboxytetramethylrhodamine‐labelled analogues of D m SP 21–36 and DmMIP 4. Injected DmSP 21–36 also failed to have an effect on L . hesperus mating receptivity. Potential divergence in the LhSPR binding pocket may be linked to receptor‐ligand co‐evolution as 9 of 13 MIPs encoded by a putative L . hesperus MIP precursor exhibit an atypical W ‐ X 7 ‐ W amide motif vs the W ‐ X 6 ‐ W amide and W ‐ X 8 ‐ W amide motifs of D rosophila MIPs and SP .
HRD Practices and Interventions: Can They Be Used in the Public Education System?.

Field: Business, Management and Accounting (Social Sciences)

HRD research has historically focused on business-related organizations, and so have HRD practitioners. Another major organizational entity that can benefit from HRD practitioner attentions is public education. Research in both areas have utilized similar theoretical frameworks, but have focused on a different “product.” HRD practitioner interventions should be effective in education, but there are obstacles to their introduction. This paper identifies HRD and education research similarities and discusses obstacles to HRD practitioners in education settings.
A CASE OF PANCREATICODUODENAL ARTERIAL ANEURYSM ASSOCIATED WITH CELIAC ARTERY COMPRESSION SYNDROME

Field: Medicine (Health Sciences)

腹腔動脈起始部が正中弓状靱帯によって圧迫されて狭窄し,膵十二指腸動脈アーケードを介した血流が増加することにより生じたと思われる下膵十二指腸動脈瘤の症例を経験した.症例は48歳,女性で,上腹部痛の精査中に3cm径の下膵十二指腸動脈瘤が発見された.動脈造影にて総肝動脈は逆行性に造影され,膵十二指腸動脈アーケードを介した上腸間膜動脈系の血流増加が示唆された.開腹下に正中弓状靱帯を切離して腹腔動脈起始部の圧迫を解除し,同時に動脈瘤を切除した.術後上腹部痛消失し, 3カ月目の動脈造影にて腹腔動脈の狭窄は軽快し,総肝動脈は順行性に造影されていた.腹腔動脈狭窄と膵十二指腸動脈瘤の合併は比較的稀であるが,破裂例の報告もあり,本症例のように待期的に圧迫解除と瘤切除を行うべきと思われた.
Implementasi Kompetensi Kepribadian Guru Dalam Pembentukan Karakter Religius Santri Pondok Pesantren Nurulhuda Pekandangan Sumenep Jawa Timur Indonesia Tahun 2022

Field: Social Sciences (Social Sciences)

Teachers must be able to synchronize their behavior according to what they teach, meaning what the teacher says is in accordance with actions that can be seen from their daily behavior. The role of the teacher really determines the implementation of a good learning process in school. Where religious character is one of the character values ​​that is developed in school. However, there needs to be an in-depth study of what causes them to still have this non-religious attitude or is it outside of the religious attitude that has been instilled in them. The problem of this research is how effective the teacher's personality competence is in forming the religious character of the students of the Nurulhuda Islamic Boarding School, Pakandangan, Sumenep, and what can support and hinder the implementation of teacher personality competence in forming the religious character of the students of the Nurulhuda Islamic Boarding School, Pakandangan, Sumenep, the 2022-2022 school year. 2023. The approach used in this research is a qualitative approach with descriptive research type. There are three components to the data collection technique, namely observation, interviews and documentation. In this research, researchers used single case data analysis techniques (single case design) with the data analysis model introduced by Miles and Hiberman, namely the data analysis process was carried out simultaneously with data collection through several stages starting from the data collection process, presentation and verification or drawing conclusions . The research conclusion is that the effectiveness of teacher personality competence in forming the religious character of students at the Nurulhuda Islamic Boarding School in Pakandangan Sumenep for the 2022-2023 academic year is the involvement of teachers as motivators, mentors, educators, inspirers, evaluators and supervisors. Apart from that, the effectiveness of the teacher's personality competence is a role model for students, providing motivation and advice to students if they commit a violation and there is always time for students even outside class hours. Where these forms are gentle, disciplined, responsible and fair. Supporting factors for implementing teacher personality competence in forming the religious character of students at the Nurulhuda Pakandangan Islamic Boarding School, Sumenep for the 2022-2023 academic year are control and supervision as well as instructions from the boarding school leadership and cooperation and mutual assistance between teaching staff. Meanwhile, the inhibiting factors are inadequate infrastructure, insufficient financing, inadequate family support and supervision when students are at home.
Seismic stability analysis of high embankments retained by assembled multi-step cantilever retaining walls pulled locally with geogrids

Field: Engineering (Physical Sciences)

This paper introduces a new retaining structure, multi-step cantilever retaining walls pulled locally with geogrids, which has advantages of light weight, quick installation and good applicability for high fill earthworks. Considering log-spiral rotation failure mechanism passing by the heel of the lowest wall members as well as pull-out failure and tensile rupture of the flexible reinforcements, an analytical procedure for seismic overall stability of the retained embankment is proposed based on the upper-bound limit analysis method combined with pseudo static approach. Analysis results of a practical example show that the proposed safety factor and critical slip surface are identical with those by numerical simulation method via FLAC3D. The safety factor increases approximately linearly with the ultimate tension force and the number of reinforcements and nonlinearly with the length of reinforcements within a certain range. Horizontal seismic force has noticeable effect on the slope stability, and vertical seismic effect becomes significant under high horizontal acceleration coefficient. The safety factor is decreasing and the critical slip surface develops obviously towards the embankment exterior as the total number of vertical wall members increases. Besides, the distribution width and setback distance from the walls of the strip surcharge have certain effects on the retained slope stability.
Women writing women: an anthology of Spanish-American theater of the 1980s

Field: Arts and Humanities (Social Sciences)

Given the high quality of Spanish American drama written by women, it is surprising how few anthologies of these works exist in either Spanish or English. The editors of this volume have performed an invaluable service in compiling this excellent selection. The playwrights included are well known in their respective countries, and some have received international acclaim. Among those included are Isidora Aguirre (Chile), Myrna Casas (Puerto Rico), Maruxa Vilalta (Mexico), Mariela Romero (Venezuela), Beatriz Seibel (Argentina), Sabina Berman (Mexico), Diana Raznovich (Argentina), and Teresa Manchal (Puerto Rico). All of the selected works share a strong criticism of the roles imposed on women by a male-dominated society and a firm belief in the power of writing to educate and bring about necessary change. This anthology has two major shortcomings: the absence of women playwrights from Central America and of works by Argentina's Griselda Gambaro, one of contemporary Latin America's most important playwrights. The translations of the selected plays are very well done. All academic and public collections.
In vitro studies of the mechanism of leukemogenesis. II. Characterization of endogenous murine leukemia viruses isolated from AKR thymic epithelial reticulum cell lines

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Thymic epithelial reticulum (TER) cell lines were established from thymuses of a young healthy AKR mouse (A2T), a preleukemic AKR mouse (A6T), and two lymphoma-bearing AKR/Ms mice (ASLT-1 and ASLT-2). Numerous type-C virus particles with occasional budding forms were observed in all cell lines. Expression of XC-detectable, N-tropic, ecotropic virus was observed in every cell line, whereas the presence of xenotropic and mink cell focus-inducing (MCF) viruses could be detected only in TER cells derived from preleukemic and leukemic mice. Expression of xenotropic virus in various cells of newborn and young AKR mice could readily be induced by IUdR treatment, whereas MCF virus was never detected in these cells, with the exception of the A2T cell line after more than 20 passages, in which MCF virus with dual-tropic infectivity emerged in addition to ecotropic and xenotropic viruses. These spontaneous and induced MCF viruses were purified, and their virological properties were characterized. The cloned MCF viruses (MCFs AT1, AT2, AT3, and AT4-IU) showed dual tropism and produced cytopathic effect-like foci in mink lung cells. Preinfection with either ecotropic or xenotropic virus interfered with the infectivity of MCF viruses. Spontaneous leukemogenesis in AKR mice was accelerated by the inoculation of MCF viruses. These findings indicate that TER cells could serve as the host cells for the genetic recombination of the endogenous MuLV; the recombinant MuLV, MCF virus, appears to be most closely associated with leukemogenesis in AKR mice.
Learning in Third Spaces: A study examining non-formal educational practices in the multicultural sociocultural landscapes of Oslo and Moscow

Field: Social Sciences (Social Sciences)

This thesis aims to explore the meanings and values that non-formal learning practices conducted in open third spaces manifest in relation to the sociocultural landscape of a multicultural city. Two sample settings are Oslo and Moscow—cities that significantly differ in culture, population size, diversity patterns and wealth index, to mention just a few factors. However, the phenomenon of third spaces (and a culture of NFL around them) is shared and, in this sense, their unlikeness provides an opportunity for a more nuanced and contextualized discussion.\nThe study builds upon the data from qualitative interviews supplemented by observations and the media review. The informants are those who create and manage thirds spaces, run NFL practices and set their agenda: programming directors of museums, libraries, cultural centers, and public spaces of a similar sort. The ambition of such spaces is generally twofold: to shape an intellectual environment of the city as well as to contribute to a stronger sense of community.\nThe data was analyzed through the conceptual lenses of the liquid modernity theory with a specific focus on such concepts as globalization, diversity, non-formal learning and city as a social construct. Third spaces were studied as sociocultural contexts in which particular educational practices are conducted to create a shared experience in the joy of learning.\nThroughout the study I argue for a number of reasons why third spaces play a critical role in contemporary multicultural urban societies. I assert that through open non-formal educational practices third spaces help construct local communities and bolster a sense of belonging and shared identity. All of these factors make life in the city better-knit, more secure and fulfilling. The study contributes to the fields of educational studies and urban anthropology shedding light on the interconnectedness of non-formal educational practices in third spaces and cohesiveness of a multicultural city.
Estimating the number of sinusoids in non-Gaussian noise using cumulants

Field: Mathematics (Physical Sciences)

The problem of determining the dominant singular values of a cumulant matrix is considered. A criterion for rank determination which is quite general and can be used for any matrix is presented. The problem addressed is important due to the surge of new techniques in the cumulant domain, most of which require knowledge of the rank of the matrix. The criterion performs reasonably well under high and low signal-to-noise ratio conditions.< >
LHD imp02 #186237.1 (analyzed)

Field: Physics and Astronomy (Physical Sciences)

Line intensities of Lyman-alpha and some impurity ions to monitor impurity behaviors, which use 20cm normal incidence monochromators, grazing incidence monochromator, and interference filter + photomultipliers (or + APD), for CIV, OVI, HI, FeXVI, CIII and OV.