jimnoneill/paper-to-field-training huggingface dataset:
Quantitative Proteomics Reveals Extensive Changes in the Ubiquitinome after Perturbation of the Proteasome by Targeted dsRNA-Mediated Subunit Knockdown in Drosophila

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The ubiquitin-proteasome system (UPS), a highly regulated mechanism including the active marking of proteins by ubiquitin to be degraded, is critical in regulating proteostasis. Dysfunctioning of the UPS has been implicated in diseases such as cancer and neurodegenerative disorders. Here we investigate the effects of proteasome malfunctioning on global proteome and ubiquitinome dynamics using SILAC proteomics in Drosophila S2 cells. dsRNA-mediated knockdown of specific proteasome target subunits is used to inactivate the proteasome. Upon this perturbation, both the global proteome and the ubiquitinome become modified to a great extent, with the overall impact on the ubiquitinome being the most dramatic. The abundances of ∼10% of all proteins are increased, while the abundances of the far majority of over 14 000 detected diGly peptides are increased, suggesting that the pool of ubiquitinated proteins is highly dynamic. Remarkably, several proteins show heterogeneous ubiquitination dynamics, with different lysine residues on the same protein showing either increased or decreased ubiquitination. This suggests the occurrence of simultaneous and functionally different ubiquitination events. This strategy offers a powerful tool to study the response of the ubiquitinome upon interruption of normal UPS activity by targeted interference and opens up new avenues for the dissection of the mode of action of individual components of the proteasome. Because this is to our knowledge the first comprehensive ubiquitinome screen upon proteasome malfunctioning in a fruit fly cell system, this data set will serve as a valuable repository for the Drosophila community.
Assessment of Resilience Due to Adoption of Technologies in Frequently Drought-Prone Regions of India

Field: Agricultural and Biological Sciences (Life Sciences)

Climate change and variability are increasingly affecting agriculture and livelihoods in developing countries, with India being particularly vulnerable. Drought is one of the major climatic constraints impacting large parts of the world. We examined the effects of drought on crop productivity, evaluated the effectiveness of technologies in mitigating these impacts and quantified the resilience gained due to technology adoption. Resilience score and resilience gain are the two indicators used to quantify resilience. The study utilized data gathered from two villages situated in Karnataka, southern India, which have implemented the National Innovations in Climate Resilient Agriculture (NICRA) program, along with data from one control village. Drought has significantly impacted the yields, and the extent of reduction ranged from 23 to 62% compared to the normal year. Adoption of climate-resilient technologies, including improved varieties, water management and livestock practices proved beneficial in increasing yield and income during drought years. The resilience score of various technologies ranged from 71 to 122%, indicating that the technologies had realized an increase in yields in the drought year in comparison to the normal year. The extent of resilience gain ranged from 7 to 68%, indicating that the adoption of technologies contributed to the yield advantage over the farmers’ practice during drought. Water harvesting and critical irrigation have the highest resilience scores and gains, and in situ moisture conservation practices such as trench cum bunding (TCB) have comparable resilience scores and gains. The diversification of enterprises at the farm has a higher resilience score and gain. There is a need to identify climate-resilient technologies that can achieve higher resilience, as the solutions are context-specific. Further, promising technologies need to be scaled by adopting multiple approaches and by creating an enabling environment so as to increase resilience in agricultural systems.
Supplementary Figure 12 from Molecular Pathways and Cellular Subsets Associated with Adverse Clinical Outcomes in Overlapping Immune-Related Myocarditis and Myositis

Field: Medicine (Health Sciences)

<p>Differentially expressed genes (DEGs) in IL1B<sup>+</sup> Myeloid cell subsets and association of frequency of cytotoxic CD8<sup>+</sup> T cells with clinical outcomes</p>
Psychological perspectives on sex: a look into receptivity to casual sex based on gender

Field: Psychology (Social Sciences)

In these three studies I attempt to explore reasons behind the differences in receptivity of men and women to dating and sexual offers from perfect strangers and whether responses vary by gender. For Studies 1 and 2, I hypothesized that there would be (1) a main effect for type of request, (2) a main effect for gender, and (3) an interaction between Gender and Type of Request. For Study 3, I additionally hypothesized that responses for both men and women would decline the more sexually explicit the offer becomes and that there would no longer be an interaction effect. My main hypotheses were supported in Study 2, but not in Studies 1 and 3, however while I did not secure main effects I did find significant simple effects for Gender and Type of Request for both studies. The third hypothesis from Study 3 was also supported (p< .05).
Cover Picture: Synthesis, Characterisation and Photophysical Study of Alkynylrhenium(I) Tricarbonyl Diimine Complexes and Their Metal‐Ion Coordination‐Assisted Metallogelation Properties (Chem. Eur. J. 38/2010)

Field: Chemistry (Physical Sciences)

Several ion-responsive alkynylrhenium(I) tricarbonyl diimine metallogelators have been designed. The sol–gel transitions and luminescence turn-on switching are induced by silver(I) or copper(I) ion coordination. This luminescent supramolecular gel assembly process can also be considered as a molecular AND logic gate. For more details see the Full Paper by V. W.-W. Yam and S.-T. Lam on page 11588 ff. Colloidal Systems In their Review on page 11516 ff., T. Perrier et al. describe the developments in the field of multifunctional nanoparticles. A combination of techniques (formulation and post-modification) can create advanced colloidal systems with unique properties for use in a multitude of applications.1 Reversible Photoswitching In their Full Paper on page 11580 ff., A. Credi et al. discuss a self-assembling system that reversibly interconverts between a thermodynamically stable pseudorotaxane form and a kinetically inert rotaxane form upon light irradiation.1 Energy Storage In their Communication on page 11543 ff., X. Zhang et al. describe the preparation of carbon–SnO2 core–sheath composite nanofibers in a controllable fashion through simple and convenient electrospinning and electrodeposition strategies. These special structures show excellent electrochemical performance, such as high Li storage capacity, long charge–discharge cycle life, and increased rate performance.1
Silicon Nanowires/Reduced Graphene Oxide Composites for Enhanced Photoelectrochemical Properties

Field: Materials Science (Physical Sciences)

The top of silicon nanowires (SiNWs) arrays was coated with reduced graphene oxide (rGO) by the facile spin-coating method. The resulting SiNWs/rGO composite exhibits enhanced photoelectrochemical properties, with short-circuit photocurrent density more than 4 times higher than that of the pristine SiNWs and more than 600 times higher than that of planar Si/rGO composite. The trapping and recombination of photogenerated carriers at the surface state of SiNWs were reduced after the application of rGO. The results of electrochemical impedance spectroscopy measurements suggest that the reduction of trapping and recombination of photogenerated carriers as well as remarkably enhancement of photoelectrochemical properties can be attributed to the low charge transfer resistance at the SiNWs-rGO interface and rGO-electrolyte interface. The method and results shown here indicate a convenient and applicable approach to further exploitation of high activity materials for photoelectrochemical applications.
Structural characterization of self-organized nanostructures

Field: Materials Science (Physical Sciences)

Self-organized nano-objects fabricated in different semiconductor systems are currently at the focus of scientific interest because of their unique electronic properties. Transmission electron microscopy and high-resolution electron microscopy have been used to study the InAs quantum dots grown by molecular-beam epitaxy (MBE) on GaAs and InP substrates. Optimal imaging conditions for visualization of quantum dots were established. Size, shape, and stability of the equilibrium island arrays were analyzed with respect to the growth conditions. Both decrease and increase of the As pressure compared to the optimal value were shown to destroy the regular arrangement of the islands. Energy benefit due to the strain relaxation in the InAs islands is likely to be the driving force for their formation.
Problems of Primary Education of Lutherans of Siberia in the Studies of a Native of the Village of Ryzhkovo I.M. Esper

Field: Arts and Humanities (Social Sciences)

The article by Ivan Mikhailovich Esper, a researcher of the history of the village of Ryzhkovo in the Omsk region and a native of this village, "My studies in elementary school" is published. This article is in the archive of the Museum of the Peoples of Siberia of the Omsk branch of the Institute of Archaeology and Ethnography SB RAS. Ivan Mikhailovich Esper was born in 1926 in the village of Ryzhkovo, Krutinsky district, Omsk region and lived there until 1943. In 1943 he was drafted into the army and participated in the Great Patriotic War of 1941-1945. After completing his military service in 1946, he remained in Soviet Estonia, working until 1990. Ivan Mikhailovich Esper met A.A. Ilyina in correspondence by e-mail when he sent her his article "The role of the Lutheran Church and the Russian state in the formation and development of the Estonian literary language" to participate in the International Scientific Conference "Lutherans in Russia: to the 300th anniversary of the spread of Lutheranism in Siberia" in 2014. He was 87 years old at the time. I.M. Esper sent to A.A. Ilyina ten of his articles on various aspects of the history of the village of Ryzhkovo, which is the first Lutheran settlement in Siberia. In the summer of 2022, A.A. Ilyina transferred these articles to the archive of the Museum of the Peoples of the North of the Omsk branch of the Institute of Archaeology and Ethnography SB RAS. The history of the village of Ryzhkovo is an interesting and unique part of the history of the Siberian region. Therefore, I.M. Esper's articles are undoubtedly of scientific value. This article highlights the biographical aspects of I.M. Esper's primary education in the village of Ryzhkovo and the problem of public education in the Russian Empire in the XIX century - early XX century and in the pre-war period of Soviet history. The article examines the history of the establishment of rural parish schools on the basis of legislative sources, provides information on the education of children in Lutheran settlements in the XIX - first half of the XX centuries. and historical information about schools in the village of Ryzhkovo in the 1920s - 1940s.
Popliteal endarterectomy at the leg level with venous enlargement patch: about 14 cases

Field: Medicine (Health Sciences)

Abstract The incidence of lesions of the popliteal artery below the knee constitutes one of the greatest problems in revascularization of the lower limb. Firstly, this segment constitutes the departure of the leg tripod, decisive crossroads for a subsequent endovascular intervention. On the other hand, it constitutes a fairly used relay point in the event of an indication for a pedal bypass. It is assumed that the performance of a popliteal endarterectomy with an enlargement by medial approach in patients with a localized lesion at this level constitutes an effective therapeutic approach and can facilitate any gesture of crural bypass or endovascular dilation later. We present a retrospective review of all patients who underwent popliteal endarterectomy with venous patch plasty for localized popliteal disease in our institution over the past 3 years.
Using Surface Plasmon Band Gap for robust, on field, biological and chemical detection

Field: Environmental Science (Physical Sciences)

Surface Plasmons (SP) are electromagnetic waves that propagate on the interface between a metal, such as gold, and a dielectric. Because they are waves concentrated around the interface, they are very sensitive to minute changes of dielectric constant on the interface. Monitoring surface plasmon propagation can therefore be used to measure the binding of molecules on top of a metallic surface, a technique called Surface Plasmon Resonance (SPR) detection. This technique is however too fragile and bulky to be incorporated in a network of embedded sensors. By using the properties of the propagation of SP in periodic media, we are exploring a new paradigm for surface plasmon sensing that will enable sensors that are much more robust and reliable. Because these sensors can be adapted to the specific detection of most molecules, we believe that they will become ultimately a powerful solution for embedded biological sensing.
Observations on Symptomatic Locatlization of Pharyngeal Foreign Bodies

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

In eukaryotes, mRNA abundance is often a poor proxy for protein abundance1–5. Despite this, the majority of methods used to dissect function in mammalian biology6 and for biomarker discovery in complex diseases7 involve manipulation or measurement of mRNA. The discrepancy between mRNA and protein abundance is likely due to several factors, including differences in the rates of translation and degradation between proteins and cell-types8, unequal contribution of individual splice variants to the production of a given protein9 and cell-type specific differences in splice variant use10. Here we performed experimental and computational time-series analysis of RNA-seq and mass-spectrometry of three key immune cell-types in human and mice and constructed mathematical mixed time-delayed splice variant models to predict protein abundances. These models had median correlations to protein abundance measurements of 0.79-0.94, which is a significant increase from the previously reported 0.21 on human protein atlas data1, and out-performed less complicated models without the usage of multiple splice variants and time-delay in cross-validation tests. We showed the importance of our models for biomarker discovery by re-analysing RNA-seq data from five different complex diseases, which led to the prediction of new disease proteins that were validated in multiple sclerosis. Our findings suggest that similar protein abundance models may be created for the most critical cell-types in the human body.
0442 Fundamental Study on Deformation and Break-up of Water Film on Wall Edge under High Speed Air Stream (First Report: Effects of Air Stream Velocity)

Field: Engineering (Physical Sciences)

Water thin film is created on stationary blades as wet stream flow expands through the last few stages of Low Pressure (LP) steam turbine. It is torn off by high-speed steam flow and broken up into various size droplets. Some large-size and accordingly low-velocity droplets strike leading edges of rotating blades with almost circumferential velocity of them. This fact causes severe erosion damage and has been recognized as a limiting factor on the overall design of the turbine. Sequential motions of water film flow driven by a turbulent air flow from wave patterns on a wall to deformation and break-up patterns on a wall edge are recorded with a high-speed camera. It indicates the wave patterns in film flows dependence on an air stream velocity and also a strong correlation between the upstream wave patterns and the downstream deformation and break-up patterns.
Big Data and Model Predictive Control for Improved Building Performance

Field: Engineering (Physical Sciences)

There has been growing interest in the application of ‘big data’ in recent years to \nunderstand and reduce energy usage in a range of areas. However, what are the \nopportunities to use these data to automatically improve a building’s performance? \nBy using a predictive model of the building to test control strategies in advance of \ntheir application, Model Predictive Control has the potential to optimise a buildings \nenergy use and internal conditions. This paper will tackle the question of whether it is \npossible to develop a suitable predictive model from data taken from a building in \noperation using the case study of a naturally ventilated school. We show that a \nbuilding-in-use is rarely perturbed enough to provide adequate data to develop a \ncontrol capable model.
Concentrations of Subprime Lending Activities, Equity Risk Factors, and Bankruptcy Filings

Field: Economics, Econometrics and Finance (Social Sciences)

High levels of bankruptcy filings in Utah along with high concentrations of subprime originated and refinanced mortgage loans raised the question of whether or not these two indicators were related. Aggregate level studies of subprime market activities have suggested the spatial nature of lending, but they have not tested it in relation to bankruptcy filings. Using multivariate analysis it was shown that the aggregated subprime market activity and equity-related risk factors, such as the use of second mortgages and estimations of the risk-related investments in real estate at the local level, had important and statistically significant effects on aggregate bankruptcy filings. Results from the model suggested that about 32% of the variance in Utah bankruptcy filings in 2003 was accounted for by housing-related predictors.
THE RELATIONSHIP OF TEACHERS' ONLINE MANAGEMENT SKILLS, INNOVATIVE ABILITY, AND PARENTAL SUPPORT WITH LEARNING INTERESTS OF FIFTH GRADE STUDENTS

Field: Social Sciences (Social Sciences)

Education is an inseparable part of the whole of human life. Because the means to obtain a decent human survival as well as part of human rights in the process of preparing oneself for a better future is through education itself. This study aims to find and analyze the relationship between teacher skills in managing online learning and the ability to innovate with students' interest in learning through parental support as an intervening variable for fifth grade students at SDN Karangjati 04. This type of research uses quantitative research, with a sample of 30 students. While the method of collecting data is through a questionnaire, then the data is analyzed using statistical analysis with multiple regression analysis, path analysis and Sobel test. Based on the results of research at SDN Karangjati 04 Kec. Bergas, Kab. Semarang shows that there is no significant relationship between teacher skills in managing online learning and the ability to innovate on students' interest in learning with parental support as an intervening variable. This is because the value of the direct relationship between the teacher's ability to manage online learning is 0.039 and the indirect relationship through mediation of parental support is 0.0380 which means that the value of the indirect relationship is smaller than the value of the direct relationship and the significance value is 0.862 more than 0.050.Keywords: Teachers Online Management, Parental Support Learning, Learning Interest
Small-x analysis on the effect of gluon recombinations inside hadrons in light of the GLR-MQ-ZRS equation

Field: Physics and Astronomy (Physical Sciences)

We present a study of the contribution of antishadowing effects on the gluon distribution functions $G(x,Q^2)$ in light of the Gribov-Levin-Ryskin-Mueller-Qiu, Zhu-Ruan-Shen (GLR-MQ-ZRS) nonlinear equation at small-$x$, where $x$ is the momentum fraction or Bjorken variable and $Q^2$ is the four momentum transfer squared or photon virtuality. In this work, we have solved the GLR-MQ-ZRS nonlinear equation using Regge like the behavior of gluons in the kinematic range of $10^{-2}\leq x \leq 10^{-6}$ and $5\,GeV^2\, \leq Q^2\leq 100\, GeV^2$ respectively. We have obtained the solution of $G(x,Q^2)$ by considering two particular cases: (a) $α_s$ fixed; and (b) the leading order QCD dependency of $α_{s}$ on $Q^2$. A comparative analysis is also performed where we compare the gluon distribution function due to inclusion of the antishadowing effect with that of the gluon distribution without including the antishadowing effect. Our obtained results of $G(x,Q^2)$ are compared with NNPDF3.0, CT14 and PDF4LHC. We also compare our results with the result obtained from the IMParton C++ package. Using the solutions of $G(x,Q^2)$, we have also predicted $x$ and $Q^2$ evolution of the logarithmic derivative of proton's $F_2$ structure function i.e. $dF_2 (x,Q^2)/d\ln Q^2$. We incorporated both the leading order(LO) and next-to-leading order (NLO) QCD contributions of the gluon-quark splitting kernels, in $dF_2 (x,Q^2)/d\ln Q^2$. Our result of $dF_2 (x,Q^2)/d\ln Q^2$ agrees reasonably well with the experimental data recorded by HERA's H1 detector.
The effect of feed intake containing whole cottonseed on blood parameters of Nellore bulls

Field: Veterinary (Health Sciences)

ABSTRACT The aim of this study was to evaluate the effect of diets containing whole cottonseed (WC) on blood biochemical parameters of bulls. Thirty bulls with 30±6 months and 382.7±28.4kg were kept in feedlot (85 days) and fed the following WC levels: 0, 2.22, 4.44, 6.66, 8.88 and 11.11%. In comparing biochemical indicators from the beginning to the end of the experiment, the control group (CG) and those fed diets containing 2.22, 8.88 and 11.11% of WC had an increase (P<0.05) in serum Ca concentrations (8.34±0.65−9.56±0.92mEqL-1). In relation to Fe (202.79±69.04−300.04±79.88µg/dL), the CG and those treated with 6.66% WC showed an increase (P<0.05) in serum concentrations. As to the Mg (1.92±0.18−2.40±0.27mEqL-1), groups treated with diet containing 2.22, 4.44 and 6.66% of WC had higher (p<0.05) concentrations at the end of the study. Regarding blood lipids, groups with diets containing 2.22; 4.44; 6.66 and 8.88% of WC increased (p<0.05), respectively, in concentrations of HDL, TG, VLDL and COL. The group that received 11.11% of WC increased (P<0.05) in the concentrations of COL and HDL. It can be concluded that diets containing WC, caused no alterations in the concentrations of blood parameters analyzed in this study, with the exception of Mg.
Reducing energy consumption with using ventilation and solar cooling, school building’s case study

Field: Energy (Physical Sciences)

The summer months are increasingly seeing a lot of hot days. Therefore, increasing demands for air conditioning in dwelling houses, hospitals, hotels, workspaces, and the other commercial buildings. In many countries air conditioning is the biggest consumer of energy in the buildings. Reducing energy consumption we can achieve in different ways.The article deals with reducing energy for cooling the various alternatives ventilation and solar cooling. The room under simulation was ventilated by six methods. Of these 6 cook lowest energy consumption and CO2 production had ventilation 90% overnight and 10% over day. Subsequently, using absorption refrigeration unit, powered by heat from the sun. In this case the power consumption is reduced to a minimum.