jimnoneill/paper-to-field-training huggingface dataset:
Orai1 mediates tumor-promoting store-operated Ca2+ entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal–regulated kinase pathway

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Gastrointestinal stromal tumors originate from interstitial cells of Cajal, the pacemaker cells of the gut. Ca 2+ regulates the pacemaker activity of interstitial cells of Cajal. Store-operated Ca 2+ entry mediates the majority of Ca 2+ entry in most cancer cells and may be a factor in regulating intracellular Ca 2+ in interstitial cells of Cajal and gastrointestinal stromal tumors. Therefore, a blockade of this mechanism may affect the progression of gastrointestinal stromal tumors. Orai1 is the pore subunit of store-operated Ca 2+ channels. Here, we reported that Orai1 was overexpressed in gastrointestinal stromal tumor tissues and was positively correlated with a high-risk grade in gastrointestinal stromal tumor patients. Furthermore, upon Orai1 silencing, the functional store-operated Ca 2+ entry in gastrointestinal stromal tumor cells was decreased, indicating that the function of store-operated Ca 2+ entry was mediated by Orai1. Inhibition of Orai1-mediated store-operated Ca 2+ entry by Orai1 silencing or store-operated Ca 2+ entry blockers (SKF-96365 and 2-aminoethyl diphenylborate) induced obvious cell proliferation suppression, cell-cycle distribution, and apoptosis stimulation in GIST-T1 cells. Conversely, Orai1 overexpression increased store-operated Ca 2+ entry and cell proliferation in GIST882 cells. In addition, we found that activation of c-KIT and the extracellular signal–regulated kinase pathway participated in the oncogenic functions of Orai1-mediated store-operated Ca 2+ entry in gastrointestinal stromal tumor cells. These results revealed that Orai1-mediated store-operated Ca 2+ entry is critical for gastrointestinal stromal tumor cell proliferation via c-KIT and ERK signaling pathway activation. Orai1-mediated store-operated Ca 2+ entry plays an oncogenic role and may be a novel prognostic factor and therapeutic target for patients with gastrointestinal stromal tumors.
Dapsone Associated Methemoglobinemia-----A Case of Blue Discoloration

Field: Medicine (Health Sciences)

Dapsone is among the medicine that belongs to sulfone groups and being used to treat leprosy and dermatitis. It inhibits the synthesis of dihydrofolic acid by competing with para-aminobenzoic acid. This is a case of a lady in her mid70&apos;s known case of pyoderma gangrenosum recently started on dapsonepresented to ED with complaint of shortness of breath, discoloration of fingers for 4days. Patient had saturation of 88% room air. Relevant examination showed blue discoloration of the finger pulps. Arterial blood gas analysis showed oxygen saturation of 98%RA and PaO2 of 87mmHg, suggestive of positive saturation gap. She was treated with IV methylene blue on the impression of methemoglobinemia and her discoloration improved rapidly. An approach to hypoxia in ED must be considered in context of saturation gap in patients suspected of having toxicological cause. Methemoglobinemia treatment requires methylene blue administration that causes rapid resolution of symptoms.
Can Otolith Elemental Signatures Record The Capture Site of Patagonian toothfish (Dissostichus eleginoides), a Fully Marine Fish in the Southern Ocean?

Field: Agricultural and Biological Sciences (Life Sciences)

Otolith chemistry has been successfully used to reconstruct the environmental history experienced by estuarine-dependent teleost fish, including movement between estuaries and coastal areas. However, application has been more limited in species exposed exclusively to oceanic waters, where gradients in physical and chemical properties are less extreme. To test whether otolith elemental signatures record spatial information in an oceanic species, we sampled otoliths from Patagonian toothfish (Dissostichus eleginoides) and used an inductively coupled plasma mass spectrometer (ICP-MS) coupled to a laser ablation system to target the outer otolith edges corresponding to the period immediately before capture. Using multivariate analysis of variance and multivariate discriminant analysis, we found that edge signatures discriminated toothfish by geographic region with near complete success: only 5% of fish caught off South America and in the Antarctic were misclassified to sampling areas in the other region. Moreover, edge signatures showed strong differences between sampling areas within each region: fish captured off South America classified to sampling areas therein with 79%-84% success, and Antarctic fish classified to sampling areas therein with 50%-67% success. These results compare favourably with rates of classification for estuarine-dependent fish, demonstrating that otolith elemental signatures can discriminate the geographic provenance of oceanic and estuarine-dependent fish.
Atmosphere dependence of oxidation kinetics of unstabilized and Nb-stabilized AISI 430 ferritic stainless steels in the temperature range 850–950°C

Field: Materials Science (Physical Sciences)

AbstractThe effect of oxygen partial pressure and temperature on the oxidation behaviour of unstabilized and Nb-stabilized AISI 430 ferritic stainless steels were investigated over the temperature range 850–950°C in air, Ar+1 vpm O2 or Ar–H2–H2O atmospheres. Isothermal thermogravimetric analyses were performed for 50 h. The microstructure of the oxide films grown on the steels were characterized by SEM and chemical analyses were performed by EDS, grazing X-ray diffraction and secondary ion mass spectrometry (SIMS). Nb-stabilized AISI 430 steel is more resistant to oxidation than unstabilized AISI 430 under all tested conditions, except above 900°C in Ar–H2–H2O. While the oxidation behaviour of unstabilized AISI 430 is strongly affected by the atmosphere composition, Nb-stabilized AISI 430 oxidation rates do not depend strongly on the atmosphere. For both steels, the chemical analyses show Cr2O3 as the main phase in the oxide scales, but solid solutions such as FeFe2−xCrxO4 and MnCr2O4 formed in almost all scales for atmospheres of Ar+1 vpm O2 or in Ar–H2–H2O, and Fe2O3 and Mn1.5Cr1.5O4, are also observed for oxidation in air.Keywords: oxidationferritic steelsAISI 430 stainless steelNb stabilized AISI 430unstabilized AISI 430Ar–H2–H2Oairargonoxygen partial pressure
Phase I Trial of Capecitabine and Weekly Irinotecan in Combination With Radiotherapy for Neoadjuvant Therapy of Rectal Cancer

Field: Medicine (Health Sciences)

Purpose To establish the feasibility and efficacy of capecitabine in combination with weekly irinotecan (CAPIRI) with concurrent pelvic radiotherapy (RT) in patients with locally advanced rectal cancer. Patients and Methods Nineteen patients with rectal cancer clinical stage T3-4, Nx received weekly irinotecan 50 mg/m 2 (days 1, 8, 15, 22, 29) and two doses of capecitabine (days 1 through 38; dose level [DL] I, 500 mg/m 2 bid; DL II, 625 mg/m 2 bid) according to phase I methodology. Three-dimensional conformal RT was given to a dose of 50.4 Gy (45 Gy + 5.4 Gy). Results On DL I, no dose-limiting toxicities occurred, whereas diarrhea grade 3 affected three of seven patients on DL II. Twelve patients were treated on DL I and received a median relative dose-intensity of 100% for both drugs. Grade 3 or 4 adverse events were observed in only one of these patients (asthenia grade 3). All patients underwent surgery and R0 resection was achieved in all patients. Pathologic complete remission was observed in four patients and another five patients had only microfoci of residual tumor. Conclusion Preoperative chemoradiotherapy with CAPIRI is feasible and well tolerated. The preliminary efficacy is good, and the tolerability is at least comparable with data for fluorouracil plus irinotecan chemoradiotherapy. Larger phase II trials of the CAPIRI-RT schedule clearly are warranted.
Optimal temperature profile for an ammonia reactor

Field: Chemical Engineering (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptimal temperature profile for an ammonia reactorBengt Maansson and Bjarne AndresenCite this: Ind. Eng. Chem. Process Des. Dev. 1986, 25, 1, 59–65Publication Date (Print):January 1, 1986Publication History Published online1 May 2002Published inissue 1 January 1986https://pubs.acs.org/doi/10.1021/i200032a010https://doi.org/10.1021/i200032a010research-articleACS PublicationsRequest reuse permissionsArticle Views698Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Elimination of directional wave spectrum contamination from noise in elevation measurements

Field: Engineering (Physical Sciences)

The Surface Contour Radar (SCR) is a 36-GHz computer-controlled airborne radar which generates a false-color-coded elevation map of the sea surface below the aircraft in real time, and can routinely produce ocean directional wave spectra with post-flight data processing which have much higher angular resolution than pitch-and-roll buoys. The SCR range measurements are not error-free and the resulting errors in the elevations corrupt the directional wave spectrum. This paper presents a technique for eliminating that contamination.
Purification of innate immunostimulant from green tea using a silkworm muscle contraction assay

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

A polysaccharide was purified from a hot water extract of green tea leaves by measuring the immunostimulatory activity in silkworm larvae. Nuclear magnetic resonance and chemical analysis of acid hydrolysates revealed that the purified substance possessed a backbone containing polygalacturonic acids with methyl ester residues. Treatment with β-glucanase attenuated the muscle contraction activity of the purified sample, suggesting that the β-glucan structure, probably as a branched form, was required for its activity. The purified fraction stimulated the production of interleukin-6 by mouse peritoneal macrophages. These results suggest that measuring immunostimulation in silkworm larvae is useful for evaluating innate immunostimulants from various sources.
Effect of IMA Ligation Technique on Bleeding Complications in Rectal Cancer Patients Undergoing Total Mesorectal Excision

Field: Medicine (Health Sciences)

Abstract

Background Inferior mesenteric artery ligation techniques for left colon and rectal resections include stapling, using an energy device, or suture ligation based on surgeon preference. To our knowledge, no studies have demonstrated superiority of one technique over the other. Methods This retrospective study utilized an institutional database for adult rectal cancer patients undergoing total mesorectal excision (2006–2021). The association between IMA ligation technique (stapled, energy, or suture ligation) and primary outcomes of intra- and 30-day post-operative bleeding complications necessitating transfusion were assessed. Primary and secondary outcomes were analyzed using ANOVA, Pearson's Chi-squared or Fisher's exact test when appropriate. Results Among the 769 rectal cancer patients included, 69 (8.97%) underwent stapled ligation, 281 (36.54%) underwent energy ligation, and 419 (54.59%) underwent suture ligation. Patients in the suture ligation group more frequently underwent open procedures (17.39% vs 19.22% vs 92.84%; p < 0.001) compared to the stapled and energy groups, respectively. There were no differences in intra- (5.80%, 3.20%, 7.16%; p = 0.082) or post-operative bleeding necessitating transfusion (7.25%, 7.47%, 5.73%; p = 0.634). However, there was significantly more bleeding post-operatively for patients in the energy cohort compared to the suture ligation cohort when receiving an open approach (14.81% vs 5.91%: p = 0.016). There were no differences in 30-day overall morbidity, readmission, reoperation, or length of stay between groups. Conclusions Energy and stapling of the IMA is as safe as traditional IMA suture ligation, with potential benefit of suture ligation over bipolar energy in decreasing post-operative bleeding when undergoing an open approach.
A Systematic Review of Augmentative and Alternative Communication Interventions for Children Aged From 0 to 6 Years

Field: Health Professions (Health Sciences)

Purpose: This systematic review evaluates the latest available evidence regard- ing augmentative and alternative communication (AAC) interventions in children from 0 to 6 years old diagnosed with various disabilities. Method: A systematic search was conducted in MEDLINE (OVID), PsycINFO (EBSCO), ERIC (ProQuest), SCIELO (WOS), Teacher Reference Center (EBSCO), and Education Database (ProQuest), and studies on AAC interventions in children from 0 to 6 years old diagnosed with various disabilities were selected independently by two reviewers (A.L.-R. and N.I.M.) according to the purpose of the review. Results: Twenty-nine of 1,709 studies met the inclusion criteria for this review. The methodological quality of the included studies was assessed, and the characteristics and results of the studies were extracted by a descriptive analysis (O.L.S. and M.O.-V.). Conclusion: This analysis revealed that children with different diagnoses show improvements in expressive and receptive communication, functional communication behaviors, communication participation skills, interaction strategies, and symbol and multisymbol production and comprehension by using various AAC systems.
Clinical efficacy observation of fast-track anesthesia for pediatric congenital heart surgery

Field: Medicine (Health Sciences)

Objective To observe the clinical efficacy of fast-track anesthesia in surgery of congenital heart disease.Methods 70 cases child admitted to the surgical treatment of congenital heart disease were randomly divided into fast-track anesthesia group(observation group) and general anesthesia group(control group),anesthesia-related indications of the two method were compared.Results Fewer patients in observation group used more than one kind of sedative after the operation(χ2=48.62,P=0.041),more patients in observation group left ICU as soon as the surgery finished than in control group(χ2=60.87,P=0.004).The post-operative feeding time,length of hospital stay were significantly shorter in the observation group than in the control group(P0.05).The medical costs were significantly less in the observation group than in the control group(t=2.314,P=0.037;t=2.438,P=0.020;t=4.354,P=0.003;χ2=53.89,P=0.026).Conclusion Fast-track anesthesia in children with congenital heart surgery can reduce the patient recovery time and reduce postoperative pulmonary complications.
4D trajectory planning in ATM with an anytime stochastic approach

Field: Computer Science (Physical Sciences)

This paper presents the Anytime Stochastic Conflict Detection and Resolution system (ASCDR), which automatically identifies conflicts between multiple aircraft and proposes the most effective solution 4D trajectory considering the available computation time. The system detects conflicts using an algorithm based on axis-aligned minimum bounding box and resolves them cooperatively using a collision-free 4D trajectory planning algorithm based on a roundabout fast initial solution and a stochastic optimization technique named Particle Swarm Optimization (PSO) to modify the 4D initial trajectories of the aircraft with an overall minimum cost. Moreover, an anytime approach using PSO is applied because determining optimal trajectories with short time intervals in the flight phase is not feasible. Thus, trajectories whose quality improves when available computation time increases are yielded. The method could be applied to Medium-Term and even Short-Term Conflict Detection and Resolution depending on the look-ahead times. The method has been validated with simulations in scenarios with multiple aerial vehicles in a common airspace.
Inappropriate Shocks within 24 hours after Implantation of a Subcutaneous Defibrillator with a Two-incision Technique

Field: Medicine (Health Sciences)

The subcutaneous implantable cardioverter-defibrillator (S-ICD) has traditionally been implanted using three incisions, but a two-incision technique has emerged involving a subaxillary and single parasternal incision.We present two cases of early inappropriate discharge after S-ICD implant with the two-incision technique.Two patients underwent S-ICD implantation using the two-incision technique.Patient 1 is a 56-year-old male with prior coronary artery bypass graft who underwent transvenous ICD extraction for pocket infection, and was later reimplanted with an S-ICD.Patient 2 is a 73-year-old male with prior mitral valve repair and severe left ventricular dysfunction.In both cases chest X-ray confirmed good lead position without evidence of subcutaneous air, and the patients were discharged the day of implant.Several hours after discharge, both patients experienced a sudden shock, and device interrogation demonstrated a decrease in signal amplitude and abrupt baseline shift, followed by an inappropriate 80-J discharge.The artifact was not reproducible on device testing the next day.No subsequent inappropriate therapy was observed on follow-up.Inappropriate S-ICD shocks are rare in the early post-implant period using traditional implant techniques.The two-incision technique is a simplified implant method, but may predispose to oversensing and inappropriate therapy in the early post-implant period, possibly due to introduction of air along the sternal track as the lead is inserted and sheath is removed.
Emerging Therapies for the Treatment of Atherosclerotic Cardiovascular Disease: From Bench to Bedside

Field: Medicine (Health Sciences)

Primarily a consequence of sedentary lifestyle, atherosclerosis has already reached pandemic proportions, and with every year the burden of it is only increasing. As low-density lipoprotein cholesterol (LDL-C) represents a crucial factor in atherosclerosis formation and progression, stringent lipid-lowering therapy could conceivably be the key to preventing the unfavorable outcomes that arise as a consequence of atherosclerosis. The use of statins in lipid-lowering is often burdened by adverse events or is insufficient to prevent cardiovascular events as a monotherapy. Therefore, in the present review, the authors aimed to discuss the underlying mechanisms of dyslipidemia and associated atherosclerotic cardiovascular disease (ASCVD) and preclinical and clinical trials of novel therapeutic approaches to its treatment, some of which are still in the early stages of development. Apart from novel therapies, a novel change in perspective is needed. Specifically, the critical objective in the future management of ASCVD is to embrace emerging evidence in the field of atherosclerosis, because clinicians are often burden by common practice and personal experience, both of which have so far been shown to be futile in the setting of atherosclerosis.
DISTRIBUTION PATTERN FOR HLA SPECIFICITIES IN THE PATIENTS WITH ACUTE MYELOID LEUKEMIA

Field: Medicine (Health Sciences)

The article presents a study on the distribution of gene polymorphisms in the histocompatibility antigens among the patients diagnosed with AML, and healthy donors in the Republic of Kazakhstan, as well as features of the HLA-A*, *B, Cw*, DRB1*, DQB1* distribution among the patients with acute myeloid leukemia (AML). HLA typing and data processing were performed at the Research and Production Center of Transfusiology, Nur-Sultan. A total of 3808 people were examined, including 3621 healthy blood donors and 187 patients diagnosed with AML. Genomic DNA for HLA typing was isolated from peripheral blood leukocytes by proteinase method using columns with silica membrane and using a set of reagents PROTRANS DNA BOX (Protrans, Germany). Typing of HLA-A, B, C, DRB1, DQB1 in the patients and blood donors was performed by polymerase chain reaction using commercial reagent kits from Protrans (PROTRANS HLA- A*/B*/DRB1* Cyclerplate System, PROTRANS HLA-C* Cyclerplate System, PROTRANS HLA-DQB1* Cyclerplate System). HLA-A*31 (OR = 1.8; CI 1.16-2.79; p < 0.01) proved to be more common in the group of patients compared to the control group, which suggesting an association between AML and presence of this antigen. The control group showed an increased frequency of HLA-A*02 antigen (OR = 0.55; CI 0.41-0.75; p < 0.01). This antigen may be, therefore, exert a protective effect in AML development. The studies of major histocompatibility complex which include HLA genes, did significantly expanded the understanding of HLA antigens which may have strong associative links with distinct diseases, and moderately or poorly expressed links in other disorders. Analysis of the literature data showed that myeloid leukemia is characterized by decreased frequency of HLA-B13, B14, B40 antigens, most often determined by antigens B16, Bw 22, B27. In this study, HLA-A*31, B*37 were associated with AML. Phenotypes with antigens HLA-A*02, B*27, C*02, DRB1*01, *04, DQB1*06 have a probable protective effect on the development of this pathology. The study has determined some features of histocompatibility gene distribution in AML patients, detection of HLA-markers that determine the risk or resistance to the occurrence of this disease. We have established characteristic specific markers of HLA system among AML patients in Kazakhstan, which may be associated with higher risk of the disease.
MOESM17 of Transcriptomic and metabolomic profiling provide novel insights into fruit development and flesh coloration in Prunus mira Koehne, a special wild peach species

Field: Agricultural and Biological Sciences (Life Sciences)

Additional file 17: Table S12. List of genes showing a high correlation (R2â >â 0.9) with the 5 anthocyanins detected as important molecules involved in the fruit flesh coloration in Prunus mira. (XLSX 68 kb)