jimnoneill/paper-to-field-training huggingface dataset:
Vision-Assisted Interactive Human-in-the-Loop Distal Upper Limb Rehabilitation Robot and its Clinical Usability Test

Field: Health Professions (Health Sciences)

In the context of stroke rehabilitation, simple structures and user-intent driven actuation are relevant features to facilitate neuroplasticity as well as deliver a sufficient number of repetitions during a single therapy session. A novel robotic treatment device for distal upper limb rehabilitation in stroke patients was developed, and a usability test was performed to assess its clinical feasibility. The rehabilitation robot was designed as a two-axis exoskeleton actuated by electric motors, consisting of forearm supination/pronation and hand grasp/release, which were selected based on a kinematic analysis of essential daily activities. A vision-assisted algorithm was utilized for user-intent extraction in a human-in-the-loop concept. A usability test was performed on six physiatrists, five biomedical engineers, five rehabilitation therapists, two chronic stroke patients, and two caregivers of the patients. After sufficient instruction, all subjects tested the robot for a minimum of 10 min and completed the evaluation form using a 7-point Likert scale. The participants found the device interesting (5.7 ± 1.2), motivating (5.8 ± 0.9), and as having less possibility of causing injury or safety issues (6.1 ± 1.1); however, the appropriateness of difficulty (4.8 ± 1.9) and comfort level (4.9 ± 1.3) were found to be relatively low. Further development of the current device would provide a good treatment option as a simple, low-cost, and clinically feasible rehabilitation robot for stroke.
Evaluation techniques for on-line testing of robust systems based on critical tasks distribution

Field: Engineering (Physical Sciences)

The process of designing robust digital systems is getting heavier and longer due to the increase of functional complexity and circuit sensitiveness [1][2]. Furthermore, aerospace and automotive electronics are including more digital systems with critical tasks distribution among several single and cheaper modules. Although collaborative hardening is providing very interesting results in terms of cost and reliability, the design process becomes more difficult. Redundant tasks, hardware and software, must be evaluated together with the global and local error mitigation techniques. Also, network links affect error propagation and mitigation. Finally, the error accumulation must be considered in these systems working in harsh conditions. In this paper we present a general method for evaluating the Single Bit Upsets (SBU) sensitivity of complex digital systems with critical tasks distribution and collaborative hardening. This method performs a detailed analysis of signal integrity along system operation thanks to hardware emulation in the early steps of the design cycle.
Corrections to "Robust Control by SOSM Facilitates Optimizing Under Actuated Induction Cap Sealing Process" [Jun 17 4511-4519]

Field: Engineering (Physical Sciences)

Three equations of the above-named article [ibid., vol. 64, no. 6, pp. 4511–4519, Jun. 2017] contain minor typing errors. The author would like to correct those mistakes. The error prone equations along with their respective corrected one are listed.
Effect of Protein Source and Iron Content of Infant Formula on Stool Characteristics

Field: Medicine (Health Sciences)

Formula-fed, term infants were evaluated in two studies that assessed the influence on stool characteristics of protein source and iron content of the formula. Parental observations of infants' stool characteristics were recorded on standard forms. Green was the primary stool color for infants receiving whey-predominant formula containing iron at 12 mg/L. A low-iron (1.5 mg/L), whey-predominant formula produced yellow stools. A casein-predominant, iron-fortified (12 mg/L) formula produced primarily yellow or brown stools, although many of the infants fed this formula also had green stools. Soft stools were common in infants fed either whey- or casein-predominant formulas. However, more infants receiving whey-predominant formulas passed watery or slimy stools than did infants receiving casein-predominant formulas. We conclude that green stools in the absence of signs of disease should be considered a normal variation of stool color.
Sounding Off The Place of Voice in Ubiquitous Digital Media

Field: Arts and Humanities (Social Sciences)

Networked communications accord the voice renewed spatial significance. How does the mobile phone influence the use and design of spaces? The conventions for modulating the voice in face-to-face exchanges are well established. But in the case of mobile communications the voice may be raised to abnormal levels. The raised voice overcomes ambient interference, and spatial distance. The voice is also the quintessential means of issuing a summons, a call, “come here, ” and hence invoking action at a distance, across space. Rousseau, one of the earliest theorists of communication, links voice and space in this way, as amplified in the case of children brought up in the countryside. Children scattered about the fields at a distance from their fathers, mothers and other children, gain practice in making themselves heard at a distance, and in adapting the loudness of the voice to the distance which separates them from those to whom they want to speak. (Rousseau, 1957 p.191). 191 Apart from the uncanny imagery of infants scattered across a sonic field, space and voice are linked through concepts of content. According to basic communication
Marine Isonitriles and Their Related Compounds

Field: Chemistry (Physical Sciences)

Marine isonitriles represent the largest group of natural products carrying the remarkable isocyanide moiety. Together with marine isothiocyanates and formamides, which originate from the same biosynthetic pathways, they offer diverse biological activities and in spite of their exotic nature they may constitute potential lead structures for pharmaceutical development. Among other biological activities, several marine isonitriles show antimalarial, antitubercular, antifouling and antiplasmodial effects. In contrast to terrestrial isonitriles, which are mostly derived from α-amino acids, the vast majority of marine representatives are of terpenoid origin. An overview of all known marine isonitriles and their congeners will be given and their biological and chemical aspects will be discussed.
Kontrollu salımda kullanılan kitosan mikroküreler ve filmler

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Thalassemia, a genetic blood disorder, occurs as a result of deformations of hemoglobin structures. Patients with thalassemia develop iron overload from chronic blood transfusions and require regular iron chelation to prevent potentially fatal iron-related complications. Deferiprone is a commercially available drug used as iron chelator for the treatment of thalassemia but the very long-term effectiveness is not clearly known yet. Therefore, some studies were carried out to find effective alternative drugs or delivery methods for treatment of thalassemia. Controlled delivery, which offers safer, more convenient, and more effective means of administering actives, seems promising with this respect. Chitosan, a natural biopolymer produced from deacetylation of chitin, has a variety of promising pharmaceutical uses and is presently considered as a novel carrier material in drug delivery systems. In this study, chitosan microspheres having different degree of deacetylation (DDA) and containing Deferiprone were prepared by oil/water emulsion method and by crosslinking with gluteraldehyde. Particle size, SEM, and in vitro drug release analysis were performed. The average sizes of the prepared microspheres increased with increasing degree of deacetylation of chitosan and with decreasing crosslinking degree. In vitro drug release studies showed that, the release rate of Deferiprone increased as the crosslinking degree increased, contrary to the expectations. This is explained by the crystalline structure of lightly crosslinked chitosan which have ordered and dense structure causing slower release rate for Deferiprone compare to highly crosslinked structures. In the second stage of the study, chitosan films hardened with gluteraldehyde were prepared by film casting method. IR, DSC and mechanical analysis were performed. For the films with various crosslinking degrees, it was
Effect Of Oxygen And Micro-Cracking On The Flotation Of Low Grade Nickel Sulphide Ore

Field: Chemical Engineering (Physical Sciences)

This study investigated the effect of oxygen and micro-cracking on the flotation of low grade nickel sulphide ore. The ore treated contained serpentine minerals which have a history of being difficult to process efficiently. The use of oxygen as a bubbling gas has been noted to be effective because it increases the pulp potential. The desired effect of micro cracking the ore is that the nickel sulphide minerals will become activated and this activation will render these minerals more susceptible to react with potassium amyl xanthate collectors, resulting in a higher recovery of nickel and hinder the recovery of other undesired minerals contained in the ore. Higher nickel recoveries were obtained when pure oxygen was used as a bubbling gas rather than the conventional air. Microwave cracking favored the recovery of nickel.
Note on the Schiller-Theater Werkstatt West Berlin 1971 Production

Field: Arts and Humanities (Social Sciences)

The first production of Happy Days, directed by Alan Schneider, was at the Cherry Lane Theatre, New York (17 September 1961) with Ruth White as Winnie. Ten years later Beckett directed the German version of the play himself, at the Schiller-Theater Werkstatt (the smaller, studio theatre of the Schiller company) with Eva Katharina Schultz as Winnie. His Regiebuch was published, the Schiller notebooks were deposited in the Samuel Beckett Archive at Reading University (as, later the English Production Notebook) and there have been detailed accounts of the rehearsal process by Ruby Cohn (in Back to Beckett) and others. In 1979 Beckett directed the play in English (its original language) at the Royal Court Theatre, with Billie Whitelaw as Winnie. His Production Notebook, edited by James Knowlson, was published in 1985. There is therefore a large body of material available for those wishing to know how the author saw the play when he directed it on different occasions.
Mast cell response during the early phase of tuberculosis: an electron-microscopic study

Field: Medicine (Health Sciences)

Guinea pig lungs were infected with Mycobacterium tuberculosis by intratracheal route and examined under electron microscope to investigate the morphological alterations of the organisms, if any, and the response of the host tissue. The bacilli showed no changes in their morphology, while the host tissues revealed several cells containing many electron-dense intracytoplasmic granules. These cells were predominantly seen during the 1st week of infection. The electron-dense bodies of these cells may be the ones observed by earlier workers and suggested to be the altered forms of tubercle bacilli. The present investigation, however, revealed them to be the granules of the mast cells. These cells were observed to respond to tuberculous infection during the first few days by appearing in large numbers crowded with intracytoplasmic granules and soon disintegrating as the result of subsequent degranulation. The above observation is presented and its significance discussed.
Single-Mode Planar And Stripe Waveguides By Proton Exchange In Lithium Tantalate And Lithium Niobate

Field: Engineering (Physical Sciences)

This presentation gives new results on single-mode planar and stripe waveguides on both lithium tantalate and lithium niobate formed by proton-exchange. The largest Δneff obtained on lithium tantalate are 0.0174 on x-cut and 0.0033 on z-cut respectively. Results on in-plane scattering, insertion loss and of microanalysis will be reported.
Esophageal Foreign Bodies in Adults from the View Point of Internal Medicine.

Field: Medicine (Health Sciences)

下咽頭・食道に異物が介在（停留）する場合を食道異物と定義する。臨床実地においては圧倒的多数例の食道異物が，電子スコープやファイバースコープといった軟性鏡により診断・治療されているため，頻度が増加あるいは減少という一定の傾向にあるかどうかを論ずることはできない。しかし，本学会の働きかけとこれに応えた形の製薬各社の努力の結果，少なくともPTP異物はわが国では激減した。X線透過性異物を含む食道異物の確定診断は，多くの場合，軟性鏡で行われているため，治療も軟性鏡下に完了するのが望ましい。そのためには，硬性鏡時代の知見を背景に，種々の把持鉗子を駆使したり，異物によってはフード，バルーン，オーバーチューブなどの内視鏡装着器具を利用することを推奨する。
A theoretical investigation into the potential usefulness of the cathepsin C ‘domino’ technique

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

Research Article| February 01 1972 A theoretical investigation into the potential usefulness of the cathepsin C ‘domino’ technique R. J. Rowlands; R. J. Rowlands 1Division of Protein Chemistry, Commonwealth Scientific and Industrial Organization, Parkville (Melbourne), Vic. 3052, Australia Search for other works by this author on: This Site PubMed Google Scholar H. Lindley H. Lindley 1Division of Protein Chemistry, Commonwealth Scientific and Industrial Organization, Parkville (Melbourne), Vic. 3052, Australia Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1972) 126 (3): 685–688. https://doi.org/10.1042/bj1260685 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation R. J. Rowlands, H. Lindley; A theoretical investigation into the potential usefulness of the cathepsin C ‘domino’ technique. Biochem J 1 February 1972; 126 (3): 685–688. doi: https://doi.org/10.1042/bj1260685 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1972 London: The Biochemical Society1972 Article PDF first page preview Close Modal You do not currently have access to this content.
Defect detection on rail surfaces by a vision based system

Field: Engineering (Physical Sciences)

A new vision based inspection technique for rail surface defects is presented. It replaces visual checks with an automatic inspection system. Colour line-scan cameras and a special image acquisition method- the so called spectral image differencing procedure (SIDP- allow the automatic detection of defects on rail surfaces, like flakes, cracks, grooves or break-offs by means of image processing. The system is already used by a rail manufacturer as inline system, but may also be used on testing vehicles. Practice shows that it produces reliable results even for heavily scaled surfaces, which usually pose serious problems to optical inspection systems due to their irregular texture.
Pogledi na slikanico

Field: Arts and Humanities (Social Sciences)

The article shows selected Slovenian and foreign definitions of the picture book, its classification and theory. It presents the literary-historical and theoretical development of picture books in Slovenia, relying on the work of both foreign (M. Nikolajeva, S. Beckett, B. Kümmerling-Meibauer) and Slovenian (M. Kobe, D. Haramija and J. Batič) researchers. We aim to present the picture book as a subject studying teaching, so we check the development of the inclusion of picture books in the Slovenian school system through the curriculum.
The future of IT in healthcare

Field: Health Professions (Health Sciences)

Author's estimates. US 23.7 49.9 36.3 48.7 8.9 Europe 14.3 30.1 23.2 31.1 10.1 Japan 3.9 8.2 5.9 7.9 8.5 Rest of the world 5.6 11.8 9.2 12.4 10.5 World total 47.5 100.0 74.6 100.0 9.4.
Antitumor activity of T cells expressing a novel anti-folate receptor alpha (FOLR1) costimulatory antigen receptor (CoStAR) in a human xenograft murine solid tumor model and implications for in-human studies.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

2535 Background: ITIL-306 is an autologous tumor-infiltrating lymphocyte (TIL) therapy that integrates T-cell receptor (TCR)-specific antigen recognition (Signal 1) with robust costimulation via the novel CoStAR transgene upon engagement with FOLR1 (Signal 2; Sukumaran, et al. JITC. 2021;9:198). Here, we assessed IL-2 independent effector function by anti-FOLR1 CoStAR T cells in vitro and evaluated activity in a novel, more representative murine solid tumor model. Methods: For in vitro studies, healthy donor T cells were manufactured to express anti-FOLR1 CoStAR or left nontransduced (NTD). Product cells were stimulated with a single (Day [D]0; ±IL-2) or serial (D0, 7, 14, 21; no IL-2) addition of target cells expressing membrane-anchored OKT3 (Signal 1) and FOLR1 (Signal 2). T-cell activation and proliferation were measured. For in vivo studies, the carcinoembryonic antigen (CEA)-positive (Signal 1) H508 cell line was engineered to express FOLR1 (Signal 2) and injected into 6 mice/group (D–21). NTD or healthy donor T cells expressing HLA-A*02-restricted anti-CEA TCR only, anti-FOLR1 CoStAR only, or dual TCR+CoStAR were given intravenously (D0), and compared with PBS control. Tumor growth, survival, and T-cell expansion were assessed in 2 donors to D96. Results: After single and serial stimulation, only anti-FOLR1 CoStAR T cells showed sustained proliferation without exogenous IL-2. PD-1 positivity was low ( < 10%) on anti-FOLR1 T cells up to D24. In vivo, T-cell persistence on D14 was increased in dual TCR+CoStAR vs anti-CEA TCR only mice ( P<.001) and all other groups ( P<.01-.001). Tumor growth up to D58 was significantly lower in dual TCR+CoStAR ( <.5 cm 3 ) vs all other groups (each > 2 cm 3 ; P<.0001). Survival was significantly longer in dual TCR+CoStAR ( P<.01) vs all other groups; only dual TCR+CoStAR mice were alive at D58, with 5/6 alive at D96. The second donor showed similar tumor control irrespective of exogenous IL-2 in responder mice, with > 50% alive at D96, and robust T-cell expansion in dual TCR+CoStAR mice. Conclusions: When combined with TCR-specific binding, CoStAR significantly enhanced T-cell proliferation, persistence, and antitumor activity in vivo vs TCR alone, resulting in tumor control and prolonged survival. Effects were not observed with CoStAR alone, underscoring that signaling through CoStAR alone does not induce T-cell effector function. The sustained proliferation of anti-FOLR1 CoStAR T cells without exogenous IL-2 support in vitro and in vivo supports a clinical TIL regimen free of high-dose IL-2. These results suggest that CoStAR may improve the clinical performance and benefit/risk profile of TILs, whereby fewer toxicities are expected with the removal of post-TIL IL-2 support. This will be explored in an upcoming first-in-human clinical study with ITIL-306.
Uncertainty Model for Configurable Hardware/Software and Resource Partitioning

Field: Computer Science (Physical Sciences)

Automatic hardware/software partitioning relies on characterization, estimation and design space exploration of the system performance and cost metrics. In real world situations, such estimates are complicated and cannot be 100 percent accurate. Furthermore, hardware/software co-design is so complicated nowadays that simply considering the bipartitioning between hardware and software is not sufficient. It is important to consider some of the other key design parameters and resource sharing together with the hardware/software partitioning problem. Under variable requirements of smart systems, more flexibility on the resource usage should be incorporated in system modelling. This paper considers uncertainty modeling for system partitioning with an enhanced set of parameters for hardware/software resource sharing. We harness state-of-the-art uncertainty theory for linear uncertain distribution and normal uncertain distribution. Our derivations convert the uncertainty model back to a regular constraint optimization problem. Experimental results show the effectiveness of our approach.
380 Building epidemiological capacity for Drug Overdose surveillance in the U.S. health departments

Field: Health Professions (Health Sciences)

Background

In response to the growing prescription drug overdose (DO) epidemic in the U.S., an Injury Surveillance Workgroup on Poisoning (ISWP) released Consensus Recommendations for National and State Poisoning Surveillance in April 2012. The ISWP proposed standardised tools to conduct and improve DO surveillance.

Methods

The Council of State and Territorial Epidemiologists (CSTE) formed an Overdose Subcommittee (OS) to raise CSTE membership awareness of DO deaths and to test the proposed DO indicators before they were widely adopted as surveil­lance tools.

Results

The CSTE OS aims and results have been discussed during monthly calls opened to all CSTE members. Several major projects were completed with voluntary participation from CSTE OS members. Analysis of death certificate (DC) data in 11 jurisdictions revealed variations in completeness and specificity of the drug-related information (e.g., DO death rates not contributed to any drug varied from 0/100,000 in New York City to 7.4/100,000 in Kentucky). A study using toxicology and DC data found that drug-specific sensitivity on DCs in three jurisdictions varied widely (23%–92% benzodiazepines, 61%–92% heroin, 91%–100% opioid analgesics). New epidemiological tools for DC data analysis were developed. Several jurisdictions worked successfully with medical examiners/coroners to improve completeness and specificity of drugs listed on DCs. The CSTE findings were presented at national conferences, published in papers, and informed the development of national guidelines for state special emphasis reports on DO death data.

Conclusions

The CSTE OS work is an ongoing learning process that already improved the DO mortality surveillance methodology and standardisation, increased the epidemiological capacity for DO reporting and data quality improvement at state and local levels, and strengthened the collaborations among epidemiologists from different jurisdictions.
Design, qualification, and acceptance of the front-door mechanisms for the OSIRIS experiment of the Rosetta mission

Field: Engineering (Physical Sciences)

The scope of the present document is to describe the Front Door Mechanism of Wide Angle Camera and Narrow Angle Camera of the OSIRS payload and to demonstrate the safety of the mechanism itself. To match the scientific goals it has to prevent the contamination of the telescopes during ground and in -flight operations. Moreover for the in-flight calibration the door itself will be used for the flat field of the cameras. The original design has been carried out according to optimisation techniques and successfully tested during the qualification and acceptance campaign. The results obtained demonstrated that the mechanism is fully compliant to the interface specifications and its performances are not affected by the environmental stresses and by the overall life cycling