jimnoneill/paper-to-field-training huggingface dataset:
Measurement of myocardial PCO2 with a microelectrode: its relation to coronary sinus PCO2

Field: Medicine (Health Sciences)

A micro-PCO2 electrode, with dimensions of 1 x 10 mm, and a 63% response time of 14 s was inserted into the left ventricular myocardium of the pentobarbital-anesthetized dog. Continuous recordings were made of myocardial PCO2 (PmCO2), arterial PCO2 (PaCO2), and coronary sinus PCO2 (CSPCO2) during variation of respiratory rate. PmCO2 and CSPCO2 were compared at varying coronary flow. PmCO2 was similar to and closely followed changes in CSPCO2. The difference between PmCO2 and CSPCO2 was -0.52 +/- 3.63 (SD) mmHg, and PmCO2 exceeded PaCO2 by 20.69 +/- 5.12 mmHg. After coronary occlusion, PmCO2, rose promptly, but CSPCO2 was only slightly elevated until the occlusion was released, when a CO2 efflux into the coronary sinus occurred. It is concluded that the electrode measures extracellular PCO2 and that extracellular and myocardial PCO2 are essentially equal. PmCO2 rises rapidly following coronary occlusion.
Fan Flutter Computations Using the Harmonic Balance Method

Field: Engineering (Physical Sciences)

An experimental forward-swept fan encountered flutter at part-speed conditions during wind tunnel testing. A new propulsion aeroelasticity code, based on a computational fluid dynamics (CFD) approach, was used to model the aeroelastic behavior of this fan. This threedimensional code models the unsteady flowfield due to blade vibrations using a harmonic balance method to solve the Navier-Stokes equations. This paper describes the flutter calculations and compares the results to experimental measurements and previous results from a time-accurate propulsion aeroelasticity code.
Clinical analysis of injection of enriched bone marrow mesenchymal stem cells through improved hollow cancellous bone screw to treat femoral neck fracture

Field: Medicine (Health Sciences)

Objective To investigate the clinical effect of injection of enriched bone marrow mesenchymal stem cells(BMSCs)through improved hollow cancellous bone screw to treat femoral neck fracture. Methods Sixty two cases of femoral neck fracture were randomly assigned to the experimental group or the control group. And then 200 ml bone marrow per patient from ilium were collected during the operation in experimental group. Enriched BMSCs were got by means of enrichment and quick hybrid technique and were injected to the position of fracture through improved hollow cancellous bone screw. The fracture of patients in control group was fixed by three traditional hollow cancellous bone screw only. The pain score,Harris hip score and the result of X-ray were evaluated and analyzed at 1,3,6,12 months in both groups. Results The rate of fracture healing at 3 months and 6 months after operation in experimental group were higher than control group( P 0.05). At12 months after operation,3 patients had bone nonunion and femoral head necrosis in experimental group,6 cases of bone nonunion and 9 cases of femoral head necrosis were found in control group. The average time of beginning to walk and Harris hip score at 12 months after operation in experimental group were better than control group. Conclusion Injecting enriched BMSCs to the position of fracture through improved hollow cancellous bone screw can improve bone union of femoral neck fracture effectively and it can reduce the probability of bone nonunion and osteonecrosis of the femoral head.
The Clinical History of the Medical Model Compared to Alternative Models

Field: Medicine (Health Sciences)

Abstract Why practitioners of alternative medicine cannot use the history and thought processes of the medical model By design, the clinical history discloses symptoms that relate to a scientific understanding of brain and body functions and disease. The clinical history searches for scientifically verifiable causes of disease, such as exposure to microbes or toxins, heredity, autoimmune reactions, and stress. Beyond the science, the art of the clinical history explores the essence of the patient. Because alternative practitioners reject scientific explanations of causality and pathogenesis, they couch their histories in terms that sell their belief system and their products.
MiRacles for babies with pulmonary hypoplasia: the effects of miR-10a and miR-200b on lung development

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

INTRODUCTION: Pulmonary hypoplasia causes high morbidity and mortality in congenital diaphragmatic hernia (CDH) patients. MiR-10a and miR-200b are overexpressed in human CDH lungs. We aimed to define their roles in lung development. METHODS: We profiled miR-10a expression with RT-qPCR and in situ hybridization using a nitrofen rat model for CDH. The effects of miR-10a on airway branching were evaluated in lung explants. MiR-200b’s role in airway branching was assessed in miR-200b knockout lung explants. Crossing miR-200b knockout mice with CFP-E-Cadherin was used to evaluate miR-200b’s effects on epithelial differentiation. RESULTS: Expression of miR-10a was altered in the nitrofen model and miR-10a mimics reversed lung hypoplasia in vitro. Heterozygous miR-200b lung explants displayed reduced airway branching. CFP-E-Cadherin/miR-200b knockout lung explants showed reduced epithelial expression. CONCLUSION: Both miR-10a and miR-200b are critical for lung development and CDH. Normalizing their expression may reverse lung hypoplasia and reduce the associated morbidity and mortality in CDH.
Geothermal Model of the North-Eastern Region of India: Its Possibilities and Limitations

Field: Earth and Planetary Sciences (Physical Sciences)

Abstract The empirical relationship between observed Pn (Sub-Moho) seismic velocities and the surface heat flow (including also the assessed crust-upper mantle temperatures) was used to improve the understanding of the regional geothermal activity of the North-Eastern Region of India. Vertical seismic velocity profile was further converted into radiogenic heat production and the knowledge of the crustal heat sources helped in both, to estimate deep temperature distribution within the crust and to evaluate the Moho heat flow. The most probable existing temperature at the crust-upper mantle boundary is between 800 and 900°C and the flow of heat from below the crust attains about 50% of observed surface heat flow, i.e, about 30mW. m-2.
Determining the best candidates for next‐generation sequencing‐based gene panel for evaluation of early‐onset epilepsy

Field: Medicine (Health Sciences)

Abstract Background Genetic testing is an emerging diagnostic approach in early‐onset epilepsy. Identification of the heterogeneous genetic causes of epilepsy may mitigate unnecessary evaluations and allow more accurate diagnosis and therapy. We aimed to uncover genetic causes of early‐onset epilepsy using next‐generation sequencing (NGS) to elucidate the diagnostic candidates and evaluate the diagnostic yield of targeted gene panel testing. Methods We evaluated 116 patients with early‐onset epilepsy developed before 2 years old and normal brain imaging using a NGS‐based targeted gene panel. Variants were classified according to their pathogenicity, and the diagnostic yield of the targeted genes and associated clinical factors were determined. Results We detected 40 disease‐causing variants with diagnostic yield of 34.5% (19 pathogenic, 21 likely pathogenic). Twelve variants were novel. The most commonly detected genes were SCN1A , associated with Dravet syndrome, and PRRT2 , associated with benign familial infantile epilepsy. Other variants were identified in ARX , SCN2A , KCNQ2 , PCDH19 , STXBP1 , DEPDC5 , and SCN8A . The age of seizure onset and family history were associated with disease‐causing variants. Conclusion Next‐generation sequencing‐based targeted testing is an effective diagnostic test, with 30%–40% comparable diagnostic yield. Patients with earlier seizure onset and family history of epilepsy were the best candidates for testing. For pediatric patients with early‐onset epilepsy, genetic diagnosis is important for accurate prognosis and treatment.
Simultaneous Down-regulation of Intracellular MicroRNA-21 and hTERT mRNA Using AS1411-functionallized Gold Nanoprobes to Achieve Targeted Anti-tumor Therapy

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Telomerase presents over-expression in most of cancer cells and has been a near-universal marker of cancer. Studies revealed that inhibiting telomerase activity by utilizing oligonucleotides to down-regulate the expression of intracellular human telomerase reverse transcriptase (hTERT) mRNA was an effective method to achieve anti-tumor therapy. Considering oncogenic microRNA-21 has been proved to indirectly up-regulate hTERT expression and drive cancer metastasis and aggression through increased telomerase activity, here we constructed a AS1411-functionallized oligonucleotide-conjugated gold nanoprobe (Au-nanoprobe) to simultaneously down-regulate intracellular microRNA-21 and hTERT mRNA by using anti-sense oligonucleotide technology to explore their targeted anti-tumor therapy effect. In vitro cell studies demonstrated that Au-nanoprobes could effectively induce apoptosis and inhibit the proliferation of cancer cells through down-regulating intracellular hTERT activity. In vivo imaging and anti-tumor studies revealed that Au-nanoprobes could accumulate at the tumor site and inhibit the growth of MCF-7 tumor xenografted on balb/c nude mice, thus exert the potential of anti-tumor therapy.
To Be a Woman in Pakistan: Stories of Struggle and Survival

Field: Social Sciences (Social Sciences)

Violence against women is a worldwide problem with multiple socio-cultural and structural reasons, all of which perpetuate different forms of violence. However, Pakistani society can viewed as a country where the worst forms of anti-women violence are grounded in deep-seated beliefs based on decadent culture, traditions, norms and social institutions that legitimize the centuries-old perpetuation of this ugly practice.KeywordsDomestic ViolencePolice OfficerGender EqualityWorld Economic ForumChild MarriageThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Postsecular Longings?

Field: Arts and Humanities (Social Sciences)

While the figure of the ‘Indian guru’ has established itself as a source of spiritual knowledge in the West, it played a unique role in the construction of the secular image of post-independence India. Historically, gurus, fakirs, or monks were considered neither a threat to the construction of secular India, nor were they given a privileged treatment on the basis of their religious denomination. Such secular ‘indifference’, however, has been challenged by competing narratives of religious modernities in popular culture, particularly in Hindi Cinema. Drawing from three recent productions – Oh My God (2012), PK (2014), and Dharam Sankat Mein (2015) – this article argues that the specific generic, cinematic, and narrative devices employed in these films gesture towards what Manav Ratti has identified as a ‘postsecular’ move in India, one that helps articulate the paradox of ‘nonsecular secularism, a non-religious religion’ wherein the figure of the guru serves as a tabula rasa of repressed secular anxieties.
Calculation of 2,3,7,8-TCDD Equivalent Concentrations of Complex Environmental

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Sufficient toxicological data are now available to permit use of conventional risk assessment techniques to estimate the hazards associated with human exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8TCDD). However, many real-world exposures involve complex mixtures of dibenzodioxins, dibenzofurans, and related compounds. Historical approaches to risk assessment on such mixtures have ranged from ignoring all compounds except itself to assuming that all compounds have potencies equal to 2,3,7,8-TCDD. An alternative approach which uses existing literature data and analytical results to calculate the 2,3,7,8-TCDD equivalent concentration of a mixture in order to predict its biological potency relative to itself is advanced here. Previously reported in vivo acute and subchronic studies and some reeently obtained analytical chemistry data are integrated here to clarify the utility of this important approach and to assess the uncertainties associated with its use. This predictive approach, and various conceptually similar ones, have now found wide applicability to the risk assessment proeess associated with exposure to complex mixtures of dioxins, dibenzofurans, and related compounds.
EXPERIMENTAL RESEARCH CONCERNING THE EFFECT OF ALUMINIUM COMPOUNDS ON ANXIETY IN MICE

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Anxiety disorders are the most common mental illnesses in adults. Anxiety distorts perception, decreases the power of concentration, affects thinking, learning, associative and evocation memory and is usually treated with benzodiazepines anxiolytic drugs - such as diazepam or oxazepam. Benzodiazepines are clinically used in racemic forms despite the fact that the pharmacological activity of the two enantiomers is different, the activity being restricted only to the enantiomers with (S) configuration. Oxazepam is also the ultimate pharmacologically active metabolite of many benzodiazepines derivatives, and it is metabolized to the inactive glucuronide. Experimental researches show that aluminium inhibits the release of mediators in the synaptosomal fractions with inhibitory effects being produced mainly by decreasing the activity of the Na + /K + -ATP-ase and to a lesser extent through direct interaction with neurotransmitter transporters. Based on these data from the literature, this study aimed to test the possible anxiolytic effect of 2 aluminium compounds (AlCl 3 and Al 2 (SO 4 ) 3 ) in mice after single and chronic administration. For testing the anxiolytic effect the suspended cross maze test was applied after different time intervals, after substances administration. The results showed that after 30 minutes both substances presented an anxiolytic effect regardless the administered dose, as compared to the control. After 120 minutes, only the higher doses of aluminium compounds maintained the anxiolytic effect. The anxiolytic effect was present also after chronic administration (14 days) for the higher dose (1 mg/kg bw) of aluminium chloride and for the lower dose (0.1 mg/ kg bw) of aluminium sulphate. Taking into account that both aluminium compounds had an anxiolytic effect, it can be concluded that this effect is mainly due to the aluminium ion.
Absence of Knowledge, Understanding, and Perception of Time (Symphasis with Time) as Approached by Halqeh Mysticism

Field: Arts and Humanities (Social Sciences)

One of the problems that lead to disease in the human being is absence of symphasis with time. As will be discussed, this problem brings about distress, irritability, and nervousness, and finally causes physical, psycheal and mental diseases and many other issues. Time quantity is always fixed; however, since people's feelings are variable (depending on the circumstances) we find time quality variable. Time is considered intelligent because its changes are regulated by the circumstances. It seems that time behaves intelligently toward humans, and for the same reason, we will encounter problems if we try to dictate to it. For instance, we have all well experienced that our insistence on rapid or slow passage of time causes us to feel it passing against our tendency. In fact, the human being has a variable sense of time.
Arabidopsis CAP Regulates the Actin Cytoskeleton Necessary for Plant Cell Elongation and Division

Field: Agricultural and Biological Sciences (Life Sciences)

An Arabidopsis cDNA (AtCAP1) that encodes a predicted protein of 476 amino acids highly homologous with the yeast cyclase-associated protein (CAP) was isolated. Expression of AtCAP1 in the budding yeast CAP mutant was able to rescue defects such as abnormal cell morphology and random budding pattern. The C-terminal domain, 158 amino acids of AtCAP1 possessing in vitro actin binding activity, was needed for the regulation of cytoskeleton-related defects of yeast. Transgenic plants overexpressing AtCAP1 under the regulation of a glucocorticoid-inducible promoter showed different levels of AtCAP1 accumulation related to the extent of growth abnormalities, in particular size reduction of leaves as well as petioles. Morphological alterations in leaves were attributable to decreased cell size and cell number in both epidermal and mesophyll cells. Tobacco suspension-cultured cells (Bright Yellow 2) overexpressing AtCAP1 exhibited defects in actin filaments and were unable to undergo mitosis. Furthermore, an immunoprecipitation experiment suggested that AtCAP1 interacted with actin in vivo. Therefore, AtCAP1 may play a functional role in actin cytoskeleton networking that is essential for proper cell elongation and division.
SEO Company in Houston

Field: Business, Management and Accounting (Social Sciences)

SEO Company in Houston can help to improve brand awareness, increase company revenue and also add more credibility to your business. Search engine optimization boosts the credibility of customers business. By spending more time to add relevant content to site, increase site speed and keywords research will help your site rank even higher. SEO does not have any cost like other marketing strategies like pay per click, search engine crawl customer website 24x7, promote useful content and helps to find new customers. With correct marketing campaigns we can identify target audience.
The Nernst Equation: Determination of Equilibrium Constants for Complex Ions of Silver

Field: Chemistry (Physical Sciences)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Nernst Equation: Determination of Equilibrium Constants for Complex Ions of SilverMartin L. Thompson and Laura J. Kateley View Author Information Lake Forest College, Department of Chemistry, 555 N. Sheridan Road, Lake Forest, IL 60045Cite this: J. Chem. Educ. 1999, 76, 1, 95Publication Date (Web):January 1, 1999Publication History Received3 August 2009Published online1 January 1999Published inissue 1 January 1999https://doi.org/10.1021/ed076p95RIGHTS & PERMISSIONSArticle Views1557Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (63 KB) Get e-AlertsSUBJECTS:Equilibrium constant,Ions,Silver,Students Get e-Alerts
Microwave based reversible unfolding and refolding of alcohol oxidase protein probed by fluorescence and circular dichroism spectroscopy

Field: Chemistry (Physical Sciences)

The reversible effect of microwave mediated denaturation of protein at low exposure time of 10 s has been demonstrated for the first time. The effect of microwave (2.45 GHz and 900 W) was confirmed in a homo-octameric alcohol oxidase in aqueous solution of pH 7.5. The unfolding events did not transverse through any intermediate states and no subunits of the protein were detached during the process. The refolding of the protein achieved at 4℃ for 24 h had regenerated the native enzyme. This reversible refolding approach excludes any chemical reagent and therefore established as simple technique for protein unfolding-folding studies.
DIGOXIN INHIBITED THE DEVELOPMENT AND THE EXPRESSION OF MORPHINE-INDUCED SENSITIZATION IN MICE

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Objective:To investigate the effects of digoxin on morphine induced behavioral sensitization.Methods:Locomotor activity was measured every 15 min for 2 hours after administration with digoxin in mice.The animals were rendered sensitization to morphine via treatment with morphine(10 mg ·kg-1,ip) for 5 days.After cessation of drugs for 7 days,all animals were challenged with morphine(10 mg ·kg-1,ip) on 12th day.Results:Digoxin dose-dependently inhibited both locomotor activity in mice and hyperlocomotion induced by acute morphine.Similar inhibition was also seen both in the development and the expression of morphine-induced behavioral sensitization.Conclusion:Digoxin inhibits both in the development and the expression of morphine-induced behavioral sensitization in mice.And the inhibitory effects of digoxin on dopamine release in brain may account for this.These findings indicate that digoxin may have the interferential potential to psychological dependence on morphine,and Na+,K+/ATPase might serve as a drug target in morphine addiction.
Tinzaparin: Considerations for Use in Clinical Practice

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

OBJECTIVE: To evaluate the safety and effectiveness of tinzaparin for the prevention and treatment of venous thromboembolism (VTE). DATA SOURCES: A MEDLINE and PubMed database search (1980–December 2002) was conducted. Only articles written in English were reviewed. STUDY SELECTION AND DATA EXTRACTION: Articles reporting the safety, efficacy, and cost-effectiveness of tinzaparin in humans were evaluated. Emphasis was placed on randomized, controlled trials. DATA SYNTHESIS: Tinzaparin sodium is a low-molecular-weight heparin (LMWH) that exerts its anticoagulant effect through inhibition of factors Xa and IIa and release of tissue factor pathway inhibitor from the vascular epithelium. Tinzaparin is indicated for treatment of acute symptomatic deep-vein thrombosis (DVT), with or without pulmonary embolism. Clinical studies suggest that tinzaparin is also effective for VTE prophylaxis, as well as other indications. Once-daily subcutaneous tinzaparin is equally or more effective than intravenous unfractionated heparin (UFH) for prevention and treatment of VTE, at least as safe as UFH for bleeding complications, and requires little or no monitoring. No dose “cap” is required for obese patients, and no initial dosing adjustments are necessary in elderly and/or renally impaired patients, although some monitoring is recommended. The few comparative data available suggest that tinzaparin efficacy may be comparable to that of other LMWHs; more comparative studies are needed. Pharmacoeconomic studies indicate a favorable cost—benefit ratio. CONCLUSIONS: Tinzaparin is safe and effective for prevention and treatment of DVT. Consistent once-daily dosing may facilitate self-administration of tinzaparin in the outpatient setting.