jimnoneill/paper-to-field-training huggingface dataset:
Recurrent nocturnal asthma after exposure to grain dust.

Field: Medicine (Health Sciences)

Bronchial provocation tests performed on two seperate occasions in a farmer with dust from his own grain led to immediate and late respiratory reactions followed, without further exposure to grain dust, by severe respiratory reactions during subsequent nights. Studies of lung function, including measurements of closing volume, suggested that both large and small airways rather than lung parenchyma were primarily involved. Examination of the grain samples together with the results of skin and serologic tests suggested that the grain mite, Glycyphagus destructor, might be an important allergen. Serum concentrations of C3 and C4 did not alter during these recurrent nocturnal asthmatic reactions.
Characterization of mutations in small heat shock proteins that influence substrate binding

Field: Biochemistry, Genetics and Molecular Biology (Life Sciences)

The small heat shock proteins (sHsp), ubiquitous cellular homeostasis machinery, are oligomeric chaperone proteins. sHsps play an important role in maintaining cell function and survival under stress conditions such as high temperatures. By binding to non‐native proteins in an ATP‐independent manner, sHsps effectively prevent harmful aggregation of denatured proteins, promote proper protein folding, or facilitate protein degradation. Defects in sHsps can result in abnormal accumulation of proteins or aberrant protein folding, which lead to many pathologies such as cataract, tumor and neurodegenerative diseases including Parkinson's disease and Alzheimer's disease. Structural studies have demonstrated that sHsps contain a highly conserved α‐crystallin domain flanked by variable N‐terminal and C‐terminal regions. They usually exist in large oligomers and are capable of adopting different oligomeric states in response to different conditions. Therefore, because of their dynamic structures, the specific mechanisms of how sHsp bind to substrate and function are still not well understood. Nonetheless, it is suggested that the variable N‐terminal region of the protein contributes to substrate binding and oligomerization. We have made several mutations in the sHsps to characterize regions that influence oligomerization and make contacts with substrate proteins. Our studies suggest that the hydrophobic regions of the N‐terminal domain are important for substrate‐binding. Additionally, mutations in the a‐crystallin domain also contribute to the dynamics of protein oligomerization and sHsp‐client interactions.
„Das Kind hat mehr Zeit als wir.“ Zeitwahrnehmung bei Kindern und Erwachsenen in Michael Endes Momo

Field: Arts and Humanities (Social Sciences)

The concepts of time and time perception are crucial in this article. Moreover, the fact that time is perceived differently from children to adults is exemplified through theory and practice. The main object of analysis is the cult classic fantasy novel Momo by Michael Ende. Published in 1973, the book emphasizes the fact that children and adults have different visions and different usage of time. While children seem to have time in abundance, focusing on play and fun ways to spend it, adults fear they don’t have enough time on their hands. Michael Ende proposes a possible worlds dystopic scenario in which relentless and cunning so-called time-thieves have power over human time. It is only little Momo with her unique, effortless approach to temporality that can save humankind from extinction. Counting on his readership being entertained by his book, Michael Ende’s novel also has the power to make us highly aware of the consequences of poor time management. For this reason, the following article also ponders over the moralizing aspects of this timeless novel.
The role of animal models in influenza vaccine research

Field: Medicine (Health Sciences)

A major challenge for research on influenza vaccines is the selection of an appropriate animal model that accurately reflects the disease and the protective immune response to influenza infection in humans. Vaccines for seasonal influenza have been available for decades and there is a wealth of data available on the immune response to these vaccines in humans, with well-established correlates of protection for inactivated influenza virus vaccines. Many of the seminal studies on vaccines for epidemic influenza were conducted in human subjects. Studies in humans are performed less frequently now than they were in the past. Therefore, as the quest for improved influenza vaccines continues, it is important to consider the use of animal models for the evaluation of influenza vaccines, and a major challenge for research on influenza vaccines is the selection of an appropriate animal model that accurately reflects the disease and the protective immune response to influenza infection in humans.
Three new species in the genus Latouchia Pocock, 1901 (Araneae, Mygalomorphae, Halonoproctidae) from Vietnam

Field: Agricultural and Biological Sciences (Life Sciences)

The current taxonomy of the trapdoor spider genus Latouchia is discussed, and three new species are described from southern Vietnam. Latouchia stridulans sp. nov. and L. schwendingeri sp. nov. are described from both sexes, L. huberi sp. nov. is described from females only. Significant morphological difference between the first species and the second two species indicates that Latouchia may need to be split into two or more genera when more information becomes available.
New Kids on the Block: On the impact of information retrieval on contextual resource integration patterns

Field: Computer Science (Physical Sciences)

The rise of new modes of interaction with AI skyrocketed the popularity, applicability, and amount of use cases. Despite this evolution, conceptual integration is falling behind. Studies suggest that there is hardly a systematization in using AI in organizations. Thus, by taking a service-dominant logic perspective, specifically, the concept of resource integration patterns, the most potent application of AI for organizational use - namely information retrieval - is analyzed. In doing so, we propose a systematization that can be applied to deepen understanding of core technical concepts, further investigate AI in contexts, and help explore research directions guided by SDL.
Influence of water deficit and genotype on protein, oil contents and some physical characteristics of sunflower seeds

Field: Agricultural and Biological Sciences (Life Sciences)

Water deficit stress and genotype effects on crude protein, oil content and some physical properties of sunflower seeds were investigated. The analyses indicated that, water deficit stress and varietal difference influenced the proximate composition of sunflower seeds. The seeds from Azargol and Hysun 33 cultivars were found to have the highest and lowest oil contents of 45 and 42% respectively, while the seeds from Hysun 25 and 33 cultivars had the highest and lowest protein contents of 39 and 32% respectively. In general, as the water supply decreased oil content and physical characteristics of each cultivar were negatively affected, but protein content of each cultivar was positively affected. The cultivar with the highest protein content in well-watered and water deficit stress condition (irrigation after 50 and 150 mm cumulative evaporation from class A evaporation pan, respectively) had the following mean physical properties: length of 9.68 ± 0.5 and 7.44 ± 0.6 mm, width of 6.52 ± 1.3 and 4.21 ± 0.4 mm, thickness of 4.08 ± 0.51 and 3.11 ± 0.004 mm, volume of 142.7 ± 18.6 and 52.11 ± 1.8 mm3, surface area of 105.7 ± 5.6 and 55.9 ± 1 mm2, mass of 55.7 ± 1.2 and 28.4 ± 1.3 g and moisture content of 11.4 and 9.8% (d.b). However, the cultivar with the highest oil content in well-watered and maximum water deficit stress condition had the following mean physical properties: length of 12.73 ± 0.7 and 9.37 ± 0.3 mm, width of 5.76 ± 0.33 and 2.98 ± 0.02 mm, thickness of 3.33 ± 0.4 and 2.06 ± 0.05 mm, volume of 137.69 ± 6.8 and 31.35 ± 1.5 mm3, surface area of 105.4 ± 5.2 and 42.1 ± 1.7 mm2, mass of 53 ± 1.8 and 25.3 ± 0.2 g and moisture content of 9.9 and 9% (d.b).

Key words: Sunflower seed, water deficit stress, physical properties, protein content.
Rainy season dietary ecology of avian species in semi-refuge habitats in Kano, Nigeria

Field: Agricultural and Biological Sciences (Life Sciences)

Birds are important natural field components, and critical to most ecosystems by supporting seeds dispersal, plant pollination and pest control amongst other functions. Data on avian diversity and feeding behavior could be used to enhance habitats and help initiate conservation strategies. Thus, to characterize the diet of local avian fauna, we selected four semi-refuge sites around Kano metropolis, where we established 22 line transects, each 900m long, spaced 150m apart. During May to October, 2017 each site was visited once a month, adding up to 132 transect-visits. Daily surveillance starts between the local hours of 6:30am to 10:30am. We also transect-surveyed tree vegetation for evaluation of the avian habitats. We recorded a total of 22 bird species belonging to 15 families, with ploceidae as the dominant, and the Laughing dove, Streptopelia senegalensis (Family: Columbidae), being the most dominant species. Over 40% of the bird species fed on insects, other arthropods and earthworms; followed in proportion by seed eaters; while only 3.7% were nectar feeders. Goodness of fit test on observed versus expected dietary item frequencies was significant (Chi-Sq=31.49; P=0.000), indicating field cafeteria habits were not random, but selective or, probably even evolutionary. The manner of food search varied amongst the species, with the Yellow-billed oxpecker, Buphagus africanus and Cattle egret, Egretta alba, expending the most continuous foraging time of 30 to 60 minutes. However, some species, e.g., Senegal coucal, Centropus senegalensis, mainly adopted the pick-and-move strategy. The Shanon- Wiener indices of diversity, H, by site, for birds was fair to moderate (1.24 to 2.53) and paralleled those for the trees. In the light of dearth of avian ecological data from the Kano region, we invite motivated ornithologists, bird enthusiasts and public agencies for research into avian movement patterns, and conservation measures that, we believe, must include habitat protection.
Profiling wrist pulse from skin surface by Advanced Vibrometer Interferometer Device

Field: Engineering (Physical Sciences)

With global trends in population aging, the need to decrease and prevent the onset of cardiovascular disease has drawn a great attention. The traditional cuff-based upper arm sphygmomanometer is still the standard method to retrieve blood pressure information for diagnostics. However, this method is not easy to be adapted by patients and is not comfortable enough to perform a long term monitoring process. In order to correlate the beating profile of the arterial pulse on the wrist skin, an Advanced Vibrometer Interferometer Device (AVID) is adopted in this study to measure the vibration amplitude of skin and compare it with blood pressure measured from the upper arm. The AVID system can measure vibration and remove the directional ambiguity by using circular polarization interferometer technique with two orthogonal polarized light beams. The displacement resolution of the system is nearly 1.0 nm and the accuracy is experimentally verified. Using an optical method to quantify wrist pule, it provides a means to perform cuff-less, noninvasive and continuous measurement. In this paper, the correlations between the amplitude of skin vibration and the actual blood pressure is studied. The success of this method could potentially set the foundation of blood pressure monitor system based on optical approaches.
Retrospective analysis of treatment-induced peripheral neuropathy (TIPN) in multiple myeloma (MM).

Field: Medicine (Health Sciences)

e19530 Background: Peripheral neuropathy (PN) is commonly present at MM diagnosis and exacerbated or induced by MM treatments. TIPN poses significant morbidity, and may result in therapy modifications (TM). We examined the “real-life” onset and severity of TIPN in newly diagnosed patients (pt) receiving anti-MM therapies. Methods: Medical records from a US community oncology network were reviewed. Newly diagnosed MM pt treated between 1/1/08 and 7/1/10, ≥18 years, and followed for ≥24 months were eligible. The protocol pre-defined inclusion of an equal number of TIPN and non-TIPN cases. Regimen-related TIPN was based on clinician judgment and/or correspondence of TIPN with regimen start/end dates. Uni- and multi-variate (MV) analyses examined association of demographic and regimen characteristics with TIPN, TIPN severity, and TM. Results: In all, 716 MM records were screened; 367 were deemed ineligible or incomplete. Of 349 eligible records, 229 were abstracted, 10 had unusable data, and 219 formed the analytic set; 120 records were excluded since the accrual target (N=225) had been met. Average age of pts was 67.0 years, 49.3% were female, 57.5% Caucasian, and 36.0% African-American (AA). A majority (56.6%) had 1 regimen prior to 1 st disease progression, 26.0% had 2 and 17.4% had >2 regimens. Overall, 138/219 (63.0%) developed PN, 123/219 (53.7%) with documented TIPN. TIPN developed during 1 st line therapy in the majority 110/123 (89.4%). Univariate analysis revealed that TIPN pt were younger, more likely to be AA, and treated more frequently with bortezomib-based regimens BTZ-BR (63.3 v 9.3%). MV analysis showed TIPN was associated with BTZ-BR (OR=14.5, 95% CI=6.5-32.2), but not age, race, gender, and diabetes. BTZ-BR compared to non BTZ-BR were associated with severe and grade 3/4 TIPN (79.3 v 20.7%; χ 2 =5.36, p=0.02), and TM (65.7 v 34.3%, χ 2 =5.57, p=0.02). Notable TM included dose reductions (66.7 v 33.3%) and delays (83.3 v 16.7%). Conclusions: In this study of newly diagnosed MM pt, TIPN developed frequently during 1st line therapy. BTZ-BR were associated with TIPN that was severe and resulted in greater TM. While this analysis represents a small pt population, the results are provocative and warrant further study.
Protein SecondaryStructure Prediction Using Machine Learning

Field: Computer Science (Physical Sciences)

Thispaperpresents anintelligent systemforprotein secondary structure prediction. Thesystemconsists ofthree pairwisely trained neuralnetworks anda Bayesian inference function applied totheneural networkoutputs foraccurate prediction. We tested oursystem ontwowell-known protein datasetdrawnfromPDB,oursystem showedtopperformances onbothdatasets.
Functional Analysis of Transgenic Cry1Iem Maize

Field: Agricultural and Biological Sciences (Life Sciences)

Abstract The genetic transformation of maize callus was induced by Agrobacterium tumefaciens. The Cry1Iem was transferred into callus of inbred line H99 maize, and the transgenic plants were detected by herbicide screening and PCR. A further Southern blotting experiment, real- time quantitative PCR and indoor/outdoor insect resistance identification test were carried out on T2 transgenic plants. The results of Southern blotting of transgenic plants showed that Cry1Iem had been successfully integrated into the maize genome. Real-time quantitative PCR showed that Cry1Iem was successfully expressed in transgenic plants. The insect resistance test showed that the resistance of the transgenic plants was significantly improved.
[Recommendations on the identification and transfer of children with critical diabetes during the COVID-19 outbreak].

Field: Medicine (Health Sciences)

Coronavirus disease 2019 (COVID-19) is the most serious public health problem in China. Children with diabetes are also among the population susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Traffic problems caused by epidemic prevention and control increase the difficulty in the management of children with severe diabetes. In order to control the spread of epidemic, children with mild diabetes are advised to be managed at home and in the community. However, how to treat children with severe diabetes effectively and safely during the outbreak of COVID-19 brings great challenges to primary doctors. The Subspecialty Group of Endocrinology and Metabolism, Society of Pediatrics, Chinese Medical Association and the Subspecialty Group of Endocrinology and Metabolism, Society of Pediatrics, Chinese Medical Doctor Association have developed the recommendations on the identification and transfer of children with critical diabetes during the COVID-19 outbreak, which provide a reference for primary doctors to quickly assess the severity of patient's condition and treat the illness accordingly, thus reducing the risk of referral infection and improving clinical prognosis.
Efficient pattern recognition and classification using a combination of maximum average correlation height and polynomial distance classifier correlation filters

Field: Computer Science (Physical Sciences)

A new technique using a combination of maximum average correlation height (MACH) filter and polynomial distance classifier correlation filter (PDCCF) for simultaneous detection and classification of single/multiple identical and dissimilar targets is proposed in this paper. In this technique, a MACH filter is formulated for each desired target class from the training images of the corresponding target with expected size and orientation variations such that the size of the filter is the same as the input scene. Then a multi-class PDCCF is formulated from the training images of all target classes such that the size of the filter is the same as the expected targets. For real time applications, the input scene is first correlated with all MACH filters and the correlation outputs are combined. The regions of interest (ROI) containing the probable targets are selected from the input scene based on the ROIs with higher correlation peak values in the combined correlation output. The PDCCF filter is then applied to these ROIs to identify target types and reject clutters and/or backgrounds. To increase the robustness of the proposed technique, multiple filters are formulated for multiple ranges of target size and/or orientation variations. This two-stage system is faster and yields more accurate results compared to the existing three-stage system, which involves wide area prescreening, detection using MACH filters, and classification using distance classifier correlation filter. The simulation results using real life imagery show that the proposed technique can detect and classify the desired targets with higher efficiency irrespective of their distortion or the number of targets present in the input scene, when compared to the alternate techniques.
Co-delivery\nof Phagocytosis Checkpoint Silencer and\nStimulator of Interferon Genes Agonist for Synergetic Cancer Immunotherapy

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Efficient\ncapture and presentation of tumor antigens by antigen-presenting\ncells (APCs), especially dendritic cells (DCs), are crucial for activating\nthe anti-tumor immunity. However, APCs are immunosuppressed in the\ntumor microenvironment, which hinders the tumor elimination. To reprogram\nAPCs for inducing strong anti-tumor immunity, we report here a co-delivery\nimmunotherapeutic strategy targeting the phagocytosis checkpoint (signal\nregulatory protein α, SIRPα) and stimulator of interferon\ngenes (STING) of APCs to jointly enhance their ability of capturing\nand presenting tumor antigens. In brief, a small interfering RNA targeting\nSIRPα (siSIRPα) and a STING agonist (cGAMP) were co-delivered\ninto APCs by the encapsulation into poly­(ethylene glycol)-<i>b</i>-poly­(lactide-<i>co</i>-glycolide)-based polymeric\nnanoparticles (NP<sub>siSIRPα/cGAMP</sub>). siSIRPα-mediated\nSIRPα silence promoted APCs to actively capture tumor antigens\nby engulfing tumor cells. The cGAMP-stimulated STING signaling pathway\nfurther enhanced the functions of APCs, thereby increased the activation\nand expansion of CD8<sup>+</sup> T cells. Using ovalbumin (OVA)-expressing\nmelanoma as a model, we demonstrated that NP<sub>siSIRPα/cGAMP</sub> stimulated the activation of OVA-specific CD8<sup>+</sup> T cells\nand induced holistic anti-tumor immune responses by reversing the\nimmunosuppressive phenotype of APCs. Collectively, this co-delivery\nstrategy synergistically enhanced the functions of APCs and can be\nextended to the treatment of tumors with poor immunogenicity.
Data from NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay

Field: Medicine (Health Sciences)

<div>Abstract<p>Nitric oxide synthases (NOS) are important mediators of progrowth signaling in tumor cells, as they regulate angiogenesis, immune response, and immune-mediated wound healing. Ionizing radiation (IR) is also an immune modulator and inducer of wound response. We hypothesized that radiation therapeutic efficacy could be improved by targeting NOS following tumor irradiation. Herein, we show enhanced radiation-induced (10 Gy) tumor growth delay in a syngeneic model (C3H) but not immunosuppressed (Nu/Nu) squamous cell carcinoma tumor-bearing mice treated post-IR with the constitutive NOS inhibitor N<sup>G</sup>-nitro-l-arginine methyl ester (L-NAME). These results suggest a requirement of T cells for improved radiation tumor response. In support of this observation, tumor irradiation induced a rapid increase in the immunosuppressive Th2 cytokine IL10, which was abated by post-IR administration of L-NAME. <i>In vivo</i> suppression of IL10 using an antisense IL10 morpholino also extended the tumor growth delay induced by radiation in a manner similar to L-NAME. Further examination of this mechanism in cultured Jurkat T cells revealed L-NAME suppression of IR-induced IL10 expression, which reaccumulated in the presence of exogenous NO donor. In addition to L-NAME, the guanylyl cyclase inhibitors ODQ and thrombospondin-1 also abated IR-induced IL10 expression in Jurkat T cells and ANA-1 macrophages, which further suggests that the immunosuppressive effects involve eNOS. Moreover, cytotoxic Th1 cytokines, including IL2, IL12p40, and IFNγ, as well as activated CD8<sup>+</sup> T cells were elevated in tumors receiving post-IR L-NAME. Together, these results suggest that post-IR NOS inhibition improves radiation tumor response via Th1 immune polarization within the tumor microenvironment. <i>Cancer Res; 75(14); 2788–99. ©2015 AACR</i>.</p></div>
Analisis Pengaruh Kinerja Keuangan Dengan Analisis Rasio Terhadap Laba Perusahaan

Field: Economics, Econometrics and Finance (Social Sciences)

This research was perfomed to examine the effect of financial performance on the stock retun by automotive companies and components listed in the Indonesia Stock Exchange period 2010 - 2014. independent variable in this study is the Current Ratio, Debt to Equity Ratio, Total Asset Turn Over, and Return on Assets. While the dependent variable in this study is Stock Return. The sample in this study consisted of 17 auto and components companies listed on the Indonesia Stock Exchange from the period 2005 to 2011. The sampling technique used was purposive sampling criteria include: automotive companies listed on the Stock Exchange the period 2005 - 2011, provides financial statement data from the years 2005 - 2011, and the company has a complete financial statement data from 2005 to 2011. Data obtained from the publication ICMD 2011 and official website BEI (www.idx.co.id). The analysis technique used is multiple regression analysis. Hypothesis testing is performed with simultaneous F test and partial t test, with a significance level of 5%. The results of multiple regression analysis showed that the effect of simultaneous Current Ratio, Debt to Equity Ratio, Total Asset Turn Over, Return on Assets and Return on Stocks have significant impact. Effect of partial indicates that the Current Ratio no effect on Stock Return, Debt to Equity Ratio no effect on Stock Return, Total Asset Turn Over no effect on Stock Return, while Return on Assets Return Stock significant effect.