jimnoneill/paper-to-field-training huggingface dataset:
Cook-Crawford's gallery

Field: Arts and Humanities (Social Sciences)

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Conceptualising L’Space Olympique : Tokyo 2020 Olympic education in thought, production and action

Field: Social Sciences (Social Sciences)

Perennial iterations of Olympic Games, and the International Olympic Committee’s (IOC) contractual obligations upon host cities, have prompted development of wide-ranging educational initiatives. Such initiatives draw on the moral idealism of Olympism underpinning the IOC and focus on sport and Physical Education (and other subject areas) as sites in which to teach personal responsibility, social values and civil responsibility. Pedagogical virtues notwithstanding, Olympic education development also serves to illustrate domestic and State acquiescence to the IOC’s political imperative to be a leading educational protagonist. Delivery of Olympic education, however, is complex and requires considerable ideological and practical synergies between institutions at international, national and local levels. Yet, institutional coalescence, mutually beneficial partnerships and meaningful experiences for end-users cannot be guaranteed. Accordingly, and furthering scholarly criticism, greater interrogation of Olympic education stakeholder relations is warranted. In this article, we employ a spatial theoretical perspective utilising the work of Henri Lefebvre to provide a means to understand educational stakeholders’ connections and activities related to the Tokyo 2020 Olympic Games. Drawing primarily on key stakeholders’ network activity, and examinations of Yoi, Don! (Tokyo2020’s flagship project), we present a case study of Olympic education spatial arrangements. In doing so, we conceptualise L’Space Olympique; a dynamic site in which Olympic thought attracts distinct stakeholder alliances, produces specific educational modes, and dictates certain forms of participatory action. While aspects of the educational output may be considered merit worthy, critique of Tokyo2020 space reveals ideological incongruities, stakeholder tensions, privileged production forms, and unquestioned consumption and compliance.
MATERIALISIC ATTITUDE AND WAY OF LIFE IN THE NOTEBOOK FILM

Field: Arts and Humanities (Social Sciences)

This study aims to find out materialistic attitude and the way of life in
The Notebook film. Specifically, this study focus on anlyzing the causes of ann’s
character and the effect of it. This study used the script and scenes/pictures of The
Notebook film containing dialogues as the sources of data and it was described in
the form of words,phrases,and sentences.The results of the study show the causes
of ann’s character of Materialistic Attitude and the way of life in The Notebook
film are materialistic oriented, hedonist,framing, and selfish. While the effects are
miserable,autonomous,mature and regret.
Human-Computer Interaction in Artificial Intelligence for Blind and Vision Impairment: An Interpretative Literature Review Based on Bibliometrics

Field: Computer Science (Physical Sciences)

The rise of artificial intelligence and particularly machine learning conduct to an emerging landscape of intelligent interactive systems. Such technologies help clinicians to detect diseases from medical imaging, and allow to describe the visual world to people with visual impairment. However, this new technological landscape comes with a set of HCI challenges. To better understand the importance of HCI in AI, we focused on blind and vision impairment as a representative application domain. Using bibliometric techniques, we retained 187 scientific publications organized in three clusters. Our findings show that HCI is absent in research related to medical computer systems but has moderate importance when the aim is to assist BVI in their daily life.
Effect of different dietary zinc sources on the semen quality, testicular histology and sex hormone concentration in broiler breeder roosters

Field: Agricultural and Biological Sciences (Life Sciences)

The aim of the present study was to evaluate the effect of different dietary zinc sources (ZnSO4, Zinc-amino acid and Zn5(OH)2Cl2H2O), on hormone levels, testicular histology and sperm quality in broiler breeder roosters. Twenty, 54-week-old broiler breeder roosters (Ross 308) were reared in individual cages. Dietary treatments were T1: a basal diet without any addition of zinc (0 Zn) (Control), T2: control diet supplemented with 110 mg Zn (sulphate)/kg, T3: control diet supplemented with 110 mg Zn (organic)/kg and T4: control diet supplemented with 110 mg Zn (hydroxide)/kg. The traits measured included blood serum IGF- and testosterone, motility, concentration, viability, and membrane integrity of sperm and testicular histology. The results indicated that, significant differences between the experimental treatments in terms of serum levels of IGF and testosterone in the 32nd and 45th weeks (p < .05). The highest levels of IGF and testosterone were observed in the organic zinc treatment (T3). The results of testicular histology, fertility and sperm quality showed that there was a significant difference between experimental treatments in terms of diameter of seminiferous tubules, spermatogonia and the motility, integrity, morphology, viability and concentration of sperm (p < .05). The highest levels of these traits were observed in the organic zinc treatment (T3) and the lowest in the control treatment. In conclusion, organic zinc compared to other forms of zinc supplement can be used as an efficient feed additive for improving the fertility status of the flock of broiler breeder roosters.HIGHLIGHTS Mineral resources are used in various ways in poultry feed. Zinc is one of the most important mineral sources in poultry nutrition. Organic zinc has been shown to perform better than other sources of zinc.
Low-lying zeros of quadratic Dirichlet $L$-functions: Lower order terms for extended support

Field: Mathematics (Physical Sciences)

We study the $1$-level density of low-lying zeros of Dirichlet $L$-functions attached to real primitive characters of conductor at most $X$. Under the Generalized Riemann Hypothesis, we give an asymptotic expansion of this quantity in descending powers of $\log X$, which is valid when the support of the Fourier transform of the corresponding even test function $ϕ$ is contained in $(-2,2)$. We uncover a phase transition when the supremum $σ$ of the support of $\hat ϕ$ reaches $1$, both in the main term and in the lower order terms. A new lower order term appearing at $σ=1$ involves the quantity $\hat ϕ(1)$, and is analogous to a lower order term which was isolated by Rudnick in the function field case.
Spinal‑pelvic sagittal imbalance and paraspinal muscle degeneration in patients with degenerative lumbar spinal stenosis: A monocentric, prospective and observational study

Field: Medicine (Health Sciences)

Degenerative lumbar spinal stenosis (DLSS) is a condition in which the body is held in a poor posture for a long period of time, resulting in a change in the stress structure of the lumbar spine that causes degenerative changes in the muscles of the spine. The sagittal balance of the spine and pelvis and the degeneration of the paravertebral muscles have been the focus of recent research. To explore the relationship between paraspinal muscle degeneration and changes in spine-pelvic sagittal parameters in patients with DLSS, 95 patients with DLSS (experimental group) and 70 healthy volunteers (control group) hospitalized in the Ordos Central Hospital between January 2020 and January 2022 were included as study subjects. All patients underwent lumbar magnetic resonance imaging and spinal X-ray using uniform criteria. The correlation between paravertebral muscle parameters and sagittal-pelvic sagittal parameters in patients with DLSS was obtained from two imaging examinations, and the data were organized and grouped in order to explore the correlation between these parameters. There was no significant difference in the general data between the two groups (P>0.05). In the L4-5 DLSS patient group, the ratio of fat infiltration in the right erector spinae (ES) muscle was negatively correlated with thoracic kyphosis (TK) (r=-0.536; P<0.05) but not significantly in the left side. The relative cross-sectional area of the left multifidus muscle (MF RCSA) was positively correlated with TK (r=0.685; r=0.615; P<0.05) but not significantly in the right side. In the L5-S1DLSS patient group, the right MF RCSA and right ES RCSA were significantly positively correlated with TK (r=0.685; r=0.615; P<0.05) but not significant in the left side. Thus, paravertebral muscle parameters were correlated with spinal-pelvic sagittal parameters in patients with DLSS.
Inhibiting effects of all-trans retinoic acid on a model implanted in the pleural cavity of nude mice

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Objective:To establish a metastatic model of human non-small cell lung carcinoma(NSCLC)and investigate the influence of treated all-trans retinoic acid(ATRA)about growth and metastasis on the metastasis model of lung caner;to explore activity of MMP-2,9 in the serum of nude mice and the possible effect on the activity of MMP-2,9 after treatment of ATRA.Methods:The metastasis model of lung cancer was established by injection of non-small cell lung carcinoma line H460 cells into the right pleural space of nude mice,and ATRA was given to the animals after establishing the metastasis model of lung cancer.Results:After injection of H460 cells,all animals developed lung tumors.The tumors spread locally to contiguous pleural and distant abdominal organs,with histological characteristics consistent with the human pathology.The weight of the pleural tumor masses decreased with ATRA compare to control(0.43±0.12 vs 0.96±0.18,P 0.05).Compare to hepatic metastasis in control,there was significant decrease(0.08±0.28 vs 4.67±4.47,P0.05)in mean number of metastasis foci with ATRA,and the incidence decreased sharply(8% vs 58 %,P0.05)for treated animals.The incidence of pancreatic tumor which were presented in 75% of control animals in only 25% of treated rats while the the median number of pancreatic metastases dropped from 9.00±7.68 to 0.67±1.50(P0.05).The mean number of retroperitonea metastasis decreased with ATRA(6.42±4.33 vs 23.00±8.75,P0.05),but the incidence was not significant(83% vs 100%,P0.05).The activity of MMP-2,9 in models was higher than the nomal,but decreased in treatment of ATRA.Conclusion:ATRA can inhibit the growth and metastasis of metastasis model of lung cancer.MMP-2,9 may be a useful molecule marker in the diagnosis and response to treatment.
Microfabrication of nano-fractal electrodes for EEG application

Field: Engineering (Physical Sciences)

Electro-encephalography is the recording of bio-potentials in the brain. Generally, needle electrodes are used for EEG application. However, with the advancement of technology, fractal electrodes have been developed recently and are as dry electrodes that do not require the use of gel. These days, with the facilities of nanotechnology and micro fabrication, new types of nano-electrodes with new materials are possible. In the present paper, design and micro-fabrication of new fractally coated nano-electrodes are discussed. The fabrication aspects under different environments for different configurations are given in detail. The work on selection of materials for optimum performance has been pursued which is presented here in brief. The testing of these electrodes on the laboratory phantoms and in vivo objects is given. These nanosize electrodes are very useful in the study and diagnosis of brain activity, particularly, in the form of an array housed in a bundle wrapped around the head over the skull. The nano fractal electrodes technique is quick, reliable and successful. The system can be made in portable form and the data can be telemetered easily in remote areas
Why Tax High-Cost Employer Health Plans?

Field: Economics, Econometrics and Finance (Social Sciences)

The Affordable Care Act’s primary method to control costs in the private health insurance market is an excise tax on high-cost employer plans, often referred to as the “Cadillac Tax.” This article examines the tax on high-cost plans in detail, focusing on whether the tax is likely to remedy the problems of fairness, overinsurance, or revenue cost that are often-cited weaknesses of the existing tax treatment of employer-provided health insurance. It concludes that the excise tax is likely to be a weak policy tool, and is unlikely to meaningfully address the core criticisms of the tax treatment of employer-provided coverage. The article argues that this result is likely driven by political constraints and an underlying ambivalence about the role of employer-provided coverage in a reformed health insurance market. It concludes by examining other potential avenues for more effectively reforming the tax treatment of employer-provided coverage.
24-Oxo metabolites of vitamin D3 analogues: disassociation of their prominent antileukemic effects from their lack of calcium modulation.

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

The seco-steroid hormone, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] inhibits proliferation and induces differentiation of malignant cells including those of the hematopoietic system. The 24-oxo metabolite of 1,25(OH)(2)D(3) also has prominent antiproliferative activities against various cancer cells. We chemically synthesized five novel 24-oxo vitamin D(3) analogues and evaluated their abilities both to inhibit clonal growth and induce differentiation of myeloid leukemia cells and to cause hypercalcemia. The 1alpha,25-dihydroxy-16-ene-D(3) [1,25(OH)(2)-16-ene-D(3)] and 1alpha,25-dihydroxy-16-ene-19-nor-D(3) [1,25(OH)(2)-16-ene-19-nor-D(3)] and their 24-oxo metabolites showed greater potency than 1,25(OH)(2)D(3) in their abilities to inhibit clonal proliferation of HL-60, NB4, and U937 leukemic cell lines as measured by methylcellulose soft-gel assay. Their inhibition of clonal growth was irreversible as analyzed by pulse exposure studies. The synthetic analogues also had greater potency than 1,25(OH)(2)D(3) to induce differentiation of HL-60 and NB4 cells as measured by generation of superoxide, nonspecific esterase production, and induction of CD11b and CD14 cell surface antigens and to increase the proportion of these cells in the G(0)-G(1) phase of the cell cycle. For most assays, the 24-oxo metabolite was slightly more potent than the unmodified analogue, and 50% activity was usually found in the nanomolar range. These analogues and their 24-oxo metabolites also inhibited fresh leukemic cell clonal proliferation. Expression of p27(KIP1), a cyclin-dependent kinase inhibitor that plays an important role in blocking the cell cycle, was found by Western blot analysis to be induced by the analogues and their 24-oxo metabolites in both HL-60 and U937 cells, suggesting a possible mechanism by which these analogues inhibit leukemic growth. Notably, the calcemic activity tested by injections of 1alpha,25-dihydroxy-16-ene-24-oxo-19-nor-D(3) in mice was at least 12-fold less than 1alpha,25(OH)(2)-16-ene-19-nor-D(3). Taken together, chemically synthesized 24-oxo metabolites of 1alpha,25(OH)(2)-16-ene-D(3) and 1alpha,25(OH)(2)-16-ene-19-nor-D(3) irreversibly inhibited proliferation and induced differentiation of acute myeloid leukemia cells with minimal toxicity; these compounds may have a role in the maintenance phase of therapy for acute myeloid leukemia.
Sinterization of Alumina and of the Alumina/Zirconia System in Microwave Ovens

Field: Materials Science (Physical Sciences)

Aluminum and zirconia oxides are ceramic materials widely used in the manufacturing of dental products, however, the thermal treatment stages demand high temperatures. Aiming at the reduction of the energy consumption and of the time necessary for the thermal treatments, this work intends to evaluate the influence of the microwave energy over the thermal processes of alumina substrate and of the alumina/zirconia system. The samples were made by slip-casting and then submitted to different thermal treatments. For the microwave oven, we used powers of 1.44 and 1.66 kW and heating times of 10, 15 and 20 minutes. The samples were submitted to the determination of physico-mechanical properties: flexural strength at three points, porosity and Vickers microhardness. Based on the analysis, we conclude that the microwaves energy is promising for the processing of dental ceramic, causing a significant reduction in the firing time.
Pharmacokinetic and pharmacodynamic studies of CD19 CAR T cell in human leukaemic xenograft models with dual‐modality imaging

Field: Pharmacology, Toxicology and Pharmaceutics (Life Sciences)

Abstract In recent years, chimeric antigen receptor T (CAR T)‐cell therapy has shown great potential in treating haematologic disease, but no breakthrough has been achieved in solid tumours. In order to clarify the antitumour mechanism of CAR T cell in solid tumours, the pharmacokinetic (PK) and pharmacodynamic (PD) investigations of CD19 CAR T cell were performed in human leukaemic xenograft mouse models. For PK investigation, we radiolabelled CD19 CAR T cell with 89 Zr and used PET imaging in the CD19‐positive and the CD19‐negative K562‐luc animal models. For PD evaluation, optical imaging, tumour volume measurement and DNA copy‐number detection were performed. Unfortunately, the qPCR results of the DNA copy number in the blood were below the detection limit. The tumour‐specific uptake was higher in the CD19‐positive model than in the CD19‐negative model, and this was consistent with the PD results. The preliminary PK and PD studies of CD19 CAR T cell in solid tumours are instructive. Considering the less efficiency of CAR T‐cell therapy of solid tumours with the limited number of CAR T cells entering the interior of solid tumours, this study is suggestive for the subsequent CAR T‐cell design and evaluation of solid tumour therapy.
Premixed Flame Kinematics in an Axially Decaying, Harmonically Oscillating Vorticity Field

Field: Engineering (Physical Sciences)

This paper describes experiments and analysis of the spatio -temporal dynamics of a bluff -body stabilized flame responding to excitation from a harmonic velocity field . The dependence of the flame response is shown to exhibit two fundamentally different dependencies on underlying parameters, referred to here as “i nterference dominated” and “dissipation dominated” behaviors. Which behavior dominates depends upon the phase velocity and decay rate of the convecting disturbance and the flame angle. The magnitude of the flame sheet wrinkling response initially increases with downstream distance, reaches a maximum and then decays. This basic envelope of flame response can also exhibit short length scale undulations, associated with wave interference effects. The bluff body nearfield response is controlled by linear proc esses, with a magnitude that grows downstream at a slope proportional to the local normal velocity of excitation. The peaking in response and far -field behavior is influenced by both linear and nonlinear effects , and controlled by phase interference , decay of the excitation , and kinematic restoration processes .
Morality as coordinated punishment: the social cognition of punitive inclinations in protest movements

Field: Psychology (Social Sciences)

In the evolutionary sciences, morality has often been researched and understood as a collection of solutions to problems of cooperation. For instance, sharing rewards fairly and equitably among a group is a solution to the problem of how to best divide resources that have been collectively earned. However, relatively little attention has been given to how punitive moral psychology is structured around solving problems of coordination and the epistemological challenges involved in determining, judging, condemning, and punishing wrongdoers in society. The current study assesses how people’s desire to punish moral wrongdoers (i.e., punitive inclinations), is influenced by their belief that others share or do not share their moral judgment (moral convergence) and the number of moral offenders (an individual All Lives Matter protester vs. a group of All Lives Matter protesters). In this case, the moral wrongdoer stimulus was a scenario of an offensive and semi-violent All Lives Matter protest that was presented to participants. The central hypotheses are that leading people to believe that most others share their moral judgment of the protest scenario will significantly increase their desire to punish the protesters and that the number of protesters would have no effect on punitive inclinations. However, the results did not support these hypotheses, and alternatively show a significant interaction effect between moral convergence and size of the protest. Additional analyses show that moral convergence is a moderator of the relationship between moral judgment and punitive inclinations, that moral judgment is predictive of punitive inclinations, and that support for Black Lives Matter over All Lives Matter is associated with greater levels of moral judgment and punitive inclinations toward the offensive All Lives Matter protest scenario.