Medicinal chemistry Front Cover Medicinal Chemistry Copyright Contents Contributors Preface Feature Article Chapter One: 150 years of the periodic table: New medicines and diagnostic agents 1. Introduction 1.1. Mendeleev´s elements 1.2. Essential elements for human beings 1.3. Minerals and metals in medicine 2. Transferrin: Transport and delivery of iron and metallodrugs 2.1. Titanium transferrin 2.2. Bismuth transferrin 2.3. Bacterial transferrin metal clusters 3. Metal complexes as imaging probes 3.1. MRI contrast agents 3.2. Metal based radiopharmaceuticals 3.2.1. Metals in radiotherapy 4. Design of metallodrugs 4.1. Gold complexes 4.2. Ruthenium anticancer complexes 4.3. Catalytic organometallic complexes 4.3.1. Transfer hydrogenation catalysts 4.4. Redox active osmium anticancer complexes 4.5. Organo Rh(III) and Ir(III) anticancer complexes 4.6. Photodynamic therapy (PDT) and photo activated chemotherapy (PACT) 4.6.1. Ruthenium(II) and iridium(III) complexes for PDT 4.6.2. Platinum complexes for PACT 4.7. Computational metal coordination chemistry 4.8. Metallo antibiotics 5. Conclusions and future outlook Acknowledgments References Chapter Two: Medicinal inorganic chemistry: New perspectives and targets for the periodic table 1. Introduction 2. The polynuclear platinum concept 2.1. Substitution inert polynuclear platinums. Non covalent interactions on DNA 2.1.1. Structural and biophysical studies 2.1.2. Comparison with polyamines and minor groove binders 2.1.2.1. DNA condensation effects 2.1.3. DNA protein interactions 2.1.4. Cellular studies 3. The extracellular matrix and bioinorganic chemistry 3.1. Metalloglycomics 3.1.1. Metalloglycomics. The case of TriplatinNC.