Artificial life and evolutionary computation : 15th Italian Workshop WIVACE 2021 Winterthur Switzerland September 15 17 2021 : revised selected papers This book constitutes the proceedings of the 15th Italian Workshop on Artificial Life and Evolutionary Computation WIVACE 2021 held in Winterthur Switzerland in September 2022.The 14 full papers and 10 short papers presented in this volume were carefully reviewed and selected from 25 submissions. The papers are organized in the following topical sections: Networks; Droplets Fluids and Synthetic Biology; Robot Systems; Computer Vision and Computational Creativity; Semantic Search; Artificial Medicine and Pharmacy; Trade and Finance; Ethics in Computational Modelling