Reverse Transcriptase Inhibitors in HIV AIDS Therapy A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV AIDS including drug discovery pharmacology development of drug resistance toxicity and prevention of mother to child transmission of HIV AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy new RTIs currently under development and the impact of approved agents on treatment in general and on vertical transmission in the developing world.