Future Trends and Challenges of Molecular Imaging and AI Innovation : Proceedings of FASMI 2020 1. X ray Tomography Study of 3D Hydrogel Structure 2. In radiolabeling of Mesenchymal Stem Cell derived Extracellular Vesicles for Quantitative in Vivo Imaging 3. A Comparative Study of Drug Distribution using Optoacoustic Tomography and Radionuclide based Sampling in PEGylated Gold Nanostars mediated Photothermal Therapy 4. CMR derived Extracellular Volume Fraction is Associated with the Ventricular Wall Thickness in Patients with Hypertrophic Cardiomyopathy 5. Upconversion nanoformulation for functional imaging 6. Three Dimensional Tomography of Cellulose Nanofibers Polypeptides Nanocomposite Hydrogels 7. Deep CNN with Conditional Random Field in Breast Cancer Metastasis Detection 8. Monitoring HDAC4 Expression in Alzheimer’s Disease Using [18F]TFAHA PET 9. Study of A Position Decoding Method Making Imaging area Continuous for A Planar Positron Imaging Probe 10. The evaluation of novel PET CT motion correction technique applied in Lung cancer patients 11. Evaluation of Radiolabeling PSMA targeted Long Circulating Peptide as a Theranostic Agent in Human Prostate Tumor bearing Mice. This volumes presents the proceedings of the FASMI 2020 conference held at Taipei Veterans General Hospital on November 20 22 2020. It presents contributions on all aspects of molecular imaging discovered by leading academic scientists and researchers. It also provides a premier interdisciplinary treatment of recent innovations trend and concerns as well as practical challenges and solutions in Molecular Imaging and put an emphasis on Artificial Intelligence applied to Imaging Data. FASMI is the annual meeting of the Federation of Asian Societies for Molecular Imaging.