Machine learning optimization and data science : 8th International Workshop LOD 2022 Certosa di Pontignano Italy September 19 22 2022 : revised selected papers Giuseppe Nicosia Varun Ojha Emanuele La Malfa Gabriela La Malfa Panos Pardalos Giuseppe Di Fatta Gíovanni Giuffrida Renato Umeton editors ; Part 1 This two volume set LNCS 13810 and 13811 constitutes the refereed proceedings of the 8th International Conference on Machine Learning Optimization and Data Science LOD 2022 together with the papers of the Second Symposium on Artificial Intelligence and Neuroscience ACAIN 2022. The total of 84 full papers presented in this two volume post conference proceedings set was carefully reviewed and selected from 226 submissions. These research articles were written by leading scientists in the fields of machine learning artificial intelligence reinforcement learning computational optimization neuroscience and data science presenting a substantial array of ideas technologies algorithms methods and applications