Green Toxicology : Making Chemicals Benign by Design Intro Title Copyright Contents Chapter 1 Green Chemistry for Green Toxicology 1.1 Introduction 1.2 Green Toxicology 1.2.1 Principle 1 Benign Design 1.2.2 Principle 2 Test Early Produce Safe 1.2.3 Principle 3 Avoid Exposure and thus Testing Needs 1.2.4 Principle 4 Make Testing Sustainable 1.2.5 Principle 5 Early Testing can use Methods not yet Mature for Regulation 1.2.6 Principle 6 Green Toxicology as a Driver of 21st Century Toxicology 1.3 Chemical Safety: Past Present and Future 1.4 Conclusion References Chapter 2 In Silico Tools to Assess Chemical Hazard 2.1 Introduction 2.2 Toxicokinetics 2.2.1 Absorption 2.2.2 Distribution 2.2.3 Metabolism 2.2.4 Elimination 2.2.5 ADME and Toxicity 2.3 Toxicodynamics 2.4 In Silico Tools for Toxicokinetics and Toxicodynamics 2.4.1 Representing Molecules Computationally 2.4.2 Using Data for Predictions 2.5 Conclusion Glossary References Chapter 3 Toxicity Testing for R&amp D Chemistry 3.1 Introduction 3.2 Cancer 3.2.1 Cancer Dose Response 3.2.2 Case Study: Glyphosate 3.3 Non cancer Endpoints 3.3.1 Irritation 3.3.2 Sensitization 3.3.3 Chronic Toxicity 3.3.4 Endocrine Disruption 3.3.5 Neurotoxicity 3.3.6 Reproductive and Developmental Toxicity 3.4 Conclusion Glossary References Chapter 4 Designing Away Exposure 4.1 Introduction 4.2 Characterizing Exposures 4.3 Characterizing Exposures in an Occupational Context 4.4 General Population and Consumer Exposures 4.5 Measuring Exposure 4.6 Predicting Environmental Fate and Exposure 4.6.1 Environmental Fate 4.6.2 Physical Chemical Properties 4.6.3 The Soil Adsorption Coefficient 4.6.4 Atmospheric Oxidation Half life 4.6.5 Hydrolysis 4.6.6 Biodegradation. Covering topics including in silico tools for hazard assessment toxicity testing and lifecycle considerations this book aims to act as a bridge between green toxicologists and green chemists.