Bioinformatics This fully revised Fourth Edition to a best selling resource provides the reader with a hands on guide to computational biology primarily in the area of sequence analysis. The subject matter will cover a broad spectrum of concepts in bioinformatics beginning with an overview of biological databases and ending with a series of chapters on predictive and comparative algorithms. Using relevant biological examples the book will provide background on and strategies for using many of the most powerful and commonly used algorithms for sequence based discovery. Given the explosion in the number of organisms whose genomes have been sequenced over the last several years the emergence of new types of data sets (particularly those derived using next generation sequencing technologies) and increasing emphasis on being able to make effective use of big data the book is both timely and important to investigators in molecular biology and related fields. With a full color enlarged page design this edition offers the most readable up to date and thorough introduction to the field for biologists. The new Foundations section insures that readers have a firm understanding of the technologies that generate the data as well as the essential statistical and programming tools. Features include special boxes enhanced use of real examples and problem sets with answers provided on the books dedicated website (www.wiley.com bioinformatics). A glossary and appendix of sample file formats rounds out the books reader friendly hands on treatment