Ethical and philosophical issues in medical imaging multimodal learning and fusion across scales for clinical decision support and topological data analysis for biomedical imaging : 1st International Workshop EPIMI 2022 12th International Workshop ML CDS 2022 2nd International Workshop TDA4BiomedicalImaging held in conjunction with MICCAI 2022 Singapore September 18 22 2022 proceedings This book constitutes the refereed joint proceedings of the 1st International Workshop on Ethical & Philosophical Issues in Medical Imaging (EPIMI 2022); the 12th International Workshop on Multimodal Learning and Fusion Across Scales for Clinical Decision Support (ML CDS 2022) and the 2nd International Workshop on Topological Data Analysis for Biomedical Imaging (TDA4BiomedicalImaging 2022) held in conjunction with the 25th International Conference on Medical Imaging and Computer Assisted Intervention MICCAI 2022 in Singapore in September 2022.EPIMI includes five short papers about various humanistic aspects of medical image computing and computer assisted interventions. The ML CDS papers discuss machine learning on multimodal data sets for clinical decision support and treatment planning. The TDA papers focus on Topological Data Analysis: a collection of techniques and tools that have matured from an increasing interest in the role topology plays in machine learning and data science