Machine Learning in Medicine Cookbook I Cluster Models Hierarchical Clustering and K means Clustering to Identify Subgroups in Surveys (50 Patients) Density based Clustering to Identify Outlier Groups in Otherwise Homogeneous Data (50 Patients) Two Step Clustering to Identify Subgroups and Predict Subgroup Memberships in Individual Future Patients (120 Patients) II Linear Models Linear Logistic and Cox Regression for Outcome Prediction with Unpaired Data (20 55 and 60 Patients) Generalized Linear Models for Outcome Prediction with Paired Data (100 Patients and 139 Physicians) Generalized Linear Models for Predicting Event Rates (50 Patients) Exact P Values Factor Analysis and Partial Least Squares (PLS) for Complex Data Reduction (250 Patients) Optimal Scaling of High sensitivity Analysis of Health Predictors (250 Patients) Discriminant Analysis for Making a Diagnosis from Multiple Outcomes (45 Patients) Weighted Least Squares for Adjusting Efficacy Data with Inconsistent Spread (78 Patients) Partial Correlations for Removing Interaction Effects from Efficacy Data (64 Patients) Canonical Regression for Overall Statistics of Multivariate Data (250 Patients). III Rules Models Neural Networks for Assessing Relationships that are Typically Nonlinear (90 Patients) Complex Samples Methodologies for Unbiased Sampling (9 678 Persons) Correspondence Analysis for Identifying the Best of Multiple Treatments in Multiple Groups (217 Patients) Decision Trees for Decision Analysis (1004 and 953 Patients) Multidimensional Scaling for Visualizing Experienced Drug Efficacies (14 Pain killers and 42 Patients) Stochastic Processes for Long Term Predictions from Short Term Observations Optimal Binning for Finding High Risk Cut offs (1445 Families) Conjoint Analysis for Determining the Most Appreciated Properties of Medicines to Be Developed (15 Physicians) Index The amount of data in medical databases doubles every 20 months and physicians are at a loss to analyze them. Also traditional methods of data analysis have difficulty to identify outliers and patterns in big data and data with multiple exposure outcome variables and analysis rules for surveys and questionnaires currently common methods of data collection are essentially missing. Obviously it is time that medical and health professionals mastered their reluctance to use machine learning and the current 100 page cookbook should be helpful to that aim. It covers in a condensed form the subjects reviewed in the 750 page three volume textbook by the same authors entitled “Machine Learning in Medicine I III” (ed. by Springer Heidelberg Germany 2013) and was written as a hand hold presentation and must read publication. It was written not only to investigators and students in the fields but also to jaded clinicians new to the methods and lacking time to read the entire textbooks. General purposes and scientific questions of the methods are only briefly mentioned but full attention is given to the technical details. The two authors a statistician and current president of the International Association of Biostatistics and a clinician and past president of the American College of Angiology provide plenty of step by step analyses from their own research and data files for self assessment are available at extras.springer.com. From their experience the authors demonstrate that machine learning performs sometimes better than traditional statistics does. Machine learning may have little options for adjusting confounding and interaction but you can add propensity scores and interaction variables to almost any machine learning method