Self Assembly of double hydrophilic block copolymers : organized particles and vesicles beyond amphiphiles The motivation of this work was to investigate the self assembly of a block copolymer species that attended little attraction before double hydrophilic block copolymers (DHBCs). DHBCs consist of two linear hydrophilic polymer blocks. The self assembly of DHBCs towards suprastructures such as particles and vesicles is determined via a strong difference in hydrophilicity between the corresponding blocks leading to a microphase separation due to immiscibility. The benefits of DHBCs and the corresponding particles and vesicles such as biocompatibility high permeability towards water and hydrophilic compounds as well as the large amount of possible functionalizations that can be addressed to the block copolymers make the application of DHBC based structures a viable choice in biomedicine. In order to assess a route towards self assembled structures from DHBCs that display the potential to act as cargos for future applications several block copolymers containing two hydrophilic polymer blocks were synthesized. [...]