Lesion segmentation in surgical and diagnostic applications : MICCAI 2022 Challenges CuRIOUS 2022 KiPA 2022 and MELA 2022 held in conjunction with MICCAI 2022 Singapore September 18 22 2022 : proceedings This book constitutes three challenges that were held in conjunction with the 25th International Conference on Medical Image Computing and Computer Assisted Intervention MICCAI 2022 which took place in Singapore in September 2022. The peer reviewed 10 papers included in this volume stem from the following three challenges: Kidney Parsing Challenge 2022: Multi Structure Segmentation for Renal Cancer Treatment (KiPA 2022) The 2022 Correction of Brain Shift with Intra Operative Ultrasound Segmentation Challenge (CuRIOUS SEG 2022) The 2022 Mediastinal Lesion Analysis Challenge (MELA 2022)