Medical applications with disentanglements : First MICCAI Workshop MAD 2022 held in conjunction with MICCAI 2022 Singapore September 22 2022 :proceedings This book constitutes the post conference proceedings of the First MICCAI Workshop on Medical Applications with Disentanglements MAD 2022 held in conjunction with MICCAI 2022 in Singapore on September22 2022.The 8 full papers presented in this book together with one short paper were carefully reviewed and cover generative adversarial networks (GAN) variational autoencoders (VAE) and normalizing flow architectures as well as a wide range of medical applications like brain age prediction skull reconstruction and unsupervised pathology disentanglement