Proceedings of COMPSTAT2010 : 19th International Conference on Computational StatisticsParis France August 22 27 2010 Keynote Invited and Contributed Papers Proceedings of the 19th international symposium on computational statistics held in Paris august 22 27 2010.Together with 3 keynote talks there were 14 invited sessions and more than 100 peer reviewed contributed communications. Part I: Keynote Part II: ABC Methods for Genetic Data Part III: Algorithms for Robust Statistics Part IV: Brain Imaging Part V: Computational Econometrics Part VI: Computer Intensive Actuarial Methods Part VII: Data Stream Mining Part VIII: Functional Data Analysis Part IX: Kernel Methods. Part X: Monte Carlo Methods in System Safety Reliability and Risk Analysis Part XI: Optimization Heuristics in Statistical Modelling Part XII: Spatial Statistics Spatial Epidemiology Part XIII: ARS Session (Financial) Time Series Part XIV: KDD Session: Topological Learning Part XV: IFCS Session: New Developments in Two or Highermode Clustering; Model Based Clustering and Reduction for High Dimensional Data Part XVI: Selected Contributed Papers Part XVII: E supplementary material: Contributed Papers.