Chemical organizations in natural reaction networks The theory of chemical organizations is applied to several reaction network models including a photochemical network of the Martian atmosphere a Petri net model of bacteriophage lambda and three models of Escherichia coli. All investigated networks are found to feature non trivial hierarchies of organizations. In several instances organizations subnetworks that are algebraically closed and self maintaining are related to biological functions and states. It is shown that the theory of chemical organizations can be used as a capable novel network analysis technique for model validation and prediction that is also suitable for genomewide models provided by systems biology approaches.