Structure based drug discovery Structure based drug discovery methods have been transformed in the last 5 10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field such as Fragment based methods are described in this book. The book describes the latest developments in technologies that can be used to obtain the 3 D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3 D protein structures in new Fragment based approaches to drug discovery are described in some detail. This book includes experimental approaches using X ray crystallography and NMR for Fragment based screening as well as other biophysical methods for studying protein ligand interactions. In addition developments in computational chemistry methodology are covered together with an assessment of practical applications. This book describes some of the most exciting developments for the discovery of new drugs such as Fragment based methods. It contains the latest developments in technologies that can be used to obtain the 3 D structures. This book includes experimental approaches using X ray crystallography and NMR for Fragment based screening as well as other biophysical methods for studying protein ligand interactions.