Maßnahmen und ihre Wirksamkeit zur Reduzierung von ESBL AmpC produzierenden Escherichia coli in der Hühnermast ESBL Interventionsmaßnahmen Masthähnchen Mathematische Modellierung Nutztierhaltung animal husbandry broiler extended spectrum beta lactamases one health public health In three different sub analyses insights were gained into the effectiveness of intervention measures against the occurrence and spread of ESBL AmpC resistant E. coli in chicken fattening farms. Literature data and practical laboratory results some of which were self obtained were incorporated into a mathematical model to predictively calculate the effects of husbandry parameters and specific intervention measures. The summarized results show an influence of the measures “competitive exclusion” “cleaning and disinfection” as well as the husbandry parameters breed “low stocking density” and increased amount of litter on some of the tested bacterial strains. In addition to the individual measures several combinations were tested in the model using two different scenarios either the pen or the day old chicks were positive before the start of fattening period. These different combinations resulted in a reduction of resistant E. coli in the infected animals in their excreta and in the litter. In this context data from experimental animal studies on combined measures would be interesting. Further scientific results could contribute to an improved model to better reflect real conditions. For example further refinement could be achieved by a dedicated mathematical calculation of the growth of resistant E. coli in the different parts of the chicken gastrointestinal tract and in the litter taking into account pH and temperature. Regardless the present version of the ...