Comparative genomics : 19th International Conference RECOMB CG 2022 La Jolla CA USA May 20–21 2022 proceedings This book constitutes the refereed proceedings of the 19th Annual RECOMB Satellite Workshop on Comparative Genomics RECOMB CG which took place in La Jolla USA during May 20 21 2022. The 18 full papers included in this book were carefully reviewed and selected from 28 submissions. The papers were organized in topical sections on evolution; phylogenetics; homology and reconciliation; genome rearrangements; metagenomics; and genomic sequencing. . Evolution On the Comparison of Bacteriophage Populations Syntenic Dimensions of Genomic Evolution Phylogenetics Fast and Accurate Branch Support Calculation for Distance based Phylogenetic Placements The Sackin Index of Simplex Networks Phylogenetic Placement Problem: A Hyperbolic Embedding Approach Phylogenetic Network Dissimilarity Measures That Take Branch Lengths Into Account Homology and Reconciliation The Complexity of Finding Common Partitions of Genomes with Predefined Block Sizes Reconciliation with Segmental Duplication Transfer Loss and Gain Quantifying Hierarchical Conflicts in Homology Statements On Partial Gene Transfer and its Impact on Gene Tree Reconstruction Genome Rearrangements Sorting by k Cuts on Signed Permutations A New Approach for the Reversal Distance with Indels and Moves in Intergenic Regions Chromothripsis Rearrangements Are Informed by 3D Genome Organization Metagenomics Using Computational Synthetic Biology Tools to Modulate Gene Expression within a Microbiome Metagenomics Binning of Long Reads Using Read Overlap Graphs A Mixed Integer Linear Programming Algorithm for Plasmid Binning Genomic Sequencing Benchmarking Penalized Regression Methods in Machine Learning for Single Cell RNA Sequencing Data Deciphering the Tissue speci c Regulatory Role of Intronless Genes Across Cancers.