A multiscale numerical framework for the simulation of anistropic material response of additively manufactured stainless steel 316L undergoing large plastic deformation Additive manufacturing (AM) offers significantly greater freedom of design compared to conventional manufacturing processes since the final parts are built layer by layer. This enables metal AM also known as metal 3D printing to be utilized for improving efficiency and functionality for the production of parts with very complex geometries and rapid prototyping. However despite many technological advancements made in recent years several challenges hinder the mass adoption of metal AM. One of these challenges is mechanical anisotropy which describes the dependency of material properties on the material orientation. Therefore in this work stainless steel 316L parts produced by laser based powder bed fusion are used to isolate and understand the root cause of anisotropy in AM parts. Furthermore an efficient and accurate multiscale numerical framework is presented for predicting the deformation behavior of actual AM parts on the macroscale undergoing large plastic deformations. Finally a novel constitutive model for the plastic spin is formulated to capture the influence of the microstructure evolution on the material behavior on the macroscale.