Gas chromatography and mass spectrometry : a practical guide The fundamentals of GC MS Introduction and history Gas chromatography The gc ms interface Mass spectrometry instrumentation Mass spectral data interpretation Quantitation with GC MS GC conditions derivatization and mass spectral interpretation Of specific compound types Acids Alcohols Aldehydes Amides Amines Amino acid Common contaminants Drugs and their metabolites Esters Ethers Fluorinated compounds Gases Glycols Halogenated compounds (other than fluorinated) Hydrocarbons Isocyanates Ketones Nitriles Nitroaromatics Nitrogen containing heterocyclics Nucleosides (TMS derivatives) Pesticides Phenols Phosphorus compounds Plasticizers and other polymer additives (including phthalates) Prostaglandins (MO TMS derivatives) Solvents and their impurities Steroids Sugars (monosaccharides) Sulfur compounds Appendices A definitions of terms related to gas chromatography B definitions of terms related to mass spectrometry C atomic masses and isotope abundances X+1 and x+2 values for ions containing atoms of C and H based on Isotope contributions E isotope peak patterns for ions containing atoms of Cl and or Br F steps to follow in the determination of an elemental composition Based on isotope peak intensity ratios G derivatization in GC MS H points of comparison of LC MS vs GC MS I list of available EI mass spectral databases J information required for reporting a GC MS analysis K third party software for use with GC MS GC installation and maintenance Troubleshooting common GC problems N maintenance operating tips and troubleshooting for mass spectrometers O mixtures for determining mass spectral resolution P cross index chart for GC stationary phases Q ions for determining unknown structures The second edition of Gas Chromatography and Mass Spectrometry: A Practical Guide follows the highly successful first edition by F.G. Kitson B.S. Larsen and C.N. McEwen (1996) which was designed as an indispensible resource for GC MS practitioners regardless of whether they are a novice or well experienced. The Fundamentals section has been extensively reworked from the original edition to give more depth of an understanding of the techniques and science involved with GC MS. Even with this expansion the original brevity and simple didactic style has been retained. Information on chromatographic peak deconvolution has been added along with a more in depth understanding of the use of mass spectral databases in the identification of unknowns. Since the last edition a number of advances in GC inlet systems and sample introduction techniques have occurred and they are included in the new edition. Other updates include a discussion on fast GC and options for combining GC detectors with mass spectrometry. The section regarding GC Conditions Derivatization and Mass Spectral Interpretation of Specific Compound Types has the same number of compound types as the original edition but the information in each section has been expanded to not only explain some of the spectra but to also explain why certain fragmentations take place. The number of Appendices has been increased from 12 to 17. The Appendix on Atomic Masses and Isotope Abundances has been expanded to provide tools to aid in determination of elemental composition from isotope peak intensity ratios. An appendix with examples on Steps to follow in the determination of elemental compositions based on isotope peak intensities has been added. Appendices on whether to use GC MS or LC MS third party software for use in data analysis list of information required in reporting GC MS data X+1 and X+2 peak relative intensities based on the number of atoms of carbon in an ion and list of available EI mass spectral databases have been added. Others such as the ones on derivatization isotope peak patterns for ions with Cl and or Br terms used in GC and in mass spectrometry and tips on setting up maintaining and troubleshooting a GC MS system have all been expanded and updated. Covers the practical instruction necessary for successful operation of GC MS equipment Reviews the latest advances in instrumentation ionization methods and quantitation Includes troubleshooting techniques and a variety of additional information useful for the GC MS practitioner A true benchtop reference A guide to a basic understanding of the components of a Gas Chromatograph Mass Spectrometer (GC MS) Quick References to data interpretation Ready source for information on new analyses