Equilibria and kinetics of biological macromolecules Thermodynamics Four basic quantum mechanical models of nuclear & electronic motion : a synopsis Molecular structure and interactions Water and the hydrophobic effect The molecular partition function System ensembles and partition functions Sampling molecular systems with simulations Binding equilibria Thermodynamics of molecular interactions Elements of statistical mechanics of liquids and solutions Analysis of binding equilibria in terms of partition functions Coupled equilibria Allosteric function Charged groups : binding of hydrogen ions solvation and charge charge interactions Some elements of polymer physics Helix coil equilibria Protein unfolding equilibria Elasticity of biological materials Kinetics Kinetics of protein folding Irreversible and stochastic processes