Nonlinear Hybrid Continuous Discrete Time Models 1. Introduction 2. Linear and quasi linear systems with piecewise constant argument 3. The reduction principle for systems with piecewise constant argument 4. The small parameter and differential equations with piecewise constant argument 5. Stability 6. The state dependent piecewise constant argument 7. Almost periodic solutions 8. Stability of neural networks 9. The blood pressure distribution 10. Integrate and fire biological oscillators. The book is mainly about hybrid systems with continuous discrete time dynamics. The major part of the book consists of the theory of equations with piece wise constant argument of generalized type. The systems as well as technique of investigation were introduced by the author very recently. They both generalized known theory about differential equations with piece wise constant argument introduced by K. Cook and J. Wiener in the 1980s. Moreover differential equations with fixed and variable moments of impulses are used to model real world problems. We consider models of neural networks blood pressure distribution and a generalized model of the cardiac pacemaker. All the results of the manuscript have not been published in any book yet. They are very recent and united with the presence of the continuous discrete dynamics of time. It is of big interest for specialists in biology medicine engineering sciences electronics. Theoretical aspects of the book meet very strong expectations of mathematicians who investigate differential equations with discontinuities of any type.