Change:
<ins> { lib , stdenv , expat , fetchFromGitHub , fetchurl , gnome2 , gst_all_1 , gtk3 , libGL , libGLU , libSM , libXinerama , libXtst , libXxf86vm , libpng , libtiff , libjpeg_turbo , zlib , pcre2 , pkg-config , xorgproto , compat28 ? false , compat30 ? true , unicode ? true , withMesa ? lib.elem stdenv.hostPlatform.system lib.platforms.mesaPlatforms , withWebKit ? stdenv.isDarwin , webkitgtk , setfile , AGL , Carbon , Cocoa , Kernel , QTKit , AVFoundation , AVKit , WebKit }: let catch = fetchFromGitHub { owner = "wxWidgets"; repo = "Catch"; rev = "5f5e4cecd1cafc85e109471356dec29e778d2160"; hash = "sha256-fB/E17tiAicAkq88Je/YFYohJ6EHJOO54oQaqiR/OzY="; }; nanosvg = fetchFromGitHub { owner = "wxWidgets"; repo = "nanosvg"; rev = "ccdb1995134d340a93fb20e3a3d323ccb3838dd0"; hash = "sha256-ymziU0NgGqxPOKHwGm0QyEdK/8jL/QYk5UdIQ3Tn8jw="; }; in stdenv.mkDerivation rec { pname = "wxwidgets"; version = "3.2.1"; src = fetchFromGitHub { owner = "wxWidgets"; repo = "wxWidgets"; rev = "v${version}"; hash = "sha256-k6td/8pF7ad7+gVm7L0jX79fHKwR7/qrOBpSFggyaI0="; }; nativeBuildInputs = [ pkg-config ]; buildInputs = [ gst_all_1.gst-plugins-base gst_all_1.gstreamer libpng libtiff libjpeg_turbo zlib pcre2 ] ++ lib.optionals stdenv.isLinux [ gtk3 libSM libXinerama libXtst libXxf86vm xorgproto ] ++ lib.optional withMesa libGLU ++ lib.optional (withWebKit && stdenv.isLinux) webkitgtk ++ lib.optional (withWebKit && stdenv.isDarwin) WebKit ++ lib.optionals stdenv.isDarwin [ expat setfile Carbon Cocoa Kernel QTKit AVFoundation AVKit WebKit ]; propagatedBuildInputs = lib.optional stdenv.isDarwin AGL; configureFlags = [ "--disable-precomp-headers" # This is the default option, but be explicit "--disable-monolithic" "--enable-mediactrl" "--with-nanosvg" (if compat28 then "--enable-compat28" else "--disable-compat28") (if compat30 then "--enable-compat30" else "--disable-compat30") ] ++ lib.optional unicode "--enable-unicode" ++ lib.optional withMesa "--with-opengl" ++ lib.optionals stdenv.isDarwin [ "--with-osx_cocoa" "--with-libiconv" ] ++ lib.optionals withWebKit [ "--enable-webview" "--enable-webviewwebkit" ]; SEARCH_LIB = "${libGLU.out}/lib ${libGL.out}/lib"; preConfigure = '' cp -r ${catch}/* 3rdparty/catch/ cp -r ${nanosvg}/* 3rdparty/nanosvg/ '' + lib.optionalString stdenv.isDarwin '' substituteInPlace configure  --replace 'ac_cv_prog_SETFILE="/Developer/Tools/SetFile"' 'ac_cv_prog_SETFILE="${setfile}/bin/SetFile"' substituteInPlace configure  --replace "-framework System" "-lSystem" ''; postInstall = " pushd $out/include ln -s wx-*/* . popd "; enableParallelBuilding = true; passthru = { inherit compat28 compat30 unicode; }; meta = with lib; { homepage = "https://www.wxwidgets.org/"; description = "A Cross-Platform C++ GUI Library"; longDescription = '' wxWidgets gives you a single, easy-to-use API for writing GUI applications on multiple platforms that still utilize the native platform's controls and utilities. Link with the appropriate library for your platform and compiler, and your application will adopt the look and feel appropriate to that platform. On top of great GUI functionality, wxWidgets gives you: online help, network programming, streams, clipboard and drag and drop, multithreading, image loading and saving in a variety of popular formats, database support, HTML viewing and printing, and much more. ''; license = licenses.wxWindows; maintainers = with maintainers; [ tfmoraes ]; platforms = platforms.unix; }; } </ins>

Discussion:
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created a to add wxgtk32