marine pharmacognosy 

Statements about this table:
microtubule be the molecular target for the hemiasterlin compound (e7974) use to treat cancer
plitidepsin be the only 1 compound on the list that be a chemical class of depsipeptide and a clinical trial β value of 1 / 7
the chemical pm00104 wih the trademark zalypsis ® be list under the molecular target : dna - binding
there be only 1 compound that have a molecular target of minor groove of dna and a phase i clinical status
microtubule be the chemical class for the bryostatin comound
when the marine organism be worm the compound be not dmxba (gts - 21)
3 compound list a chemical class of depsipeptide and a clinical trial β value of 1 / 7
trademark zalypsis ® be list under the molecular target : alkaloid
there be only 1 trademark that list a molecular target of minor groove of dna with a disease area of cancer
clinical status
compound name
trademark
marine organism α
chemical class
molecular target
clinical trials β
disease area
fda - approved
cytarabine (ara - c)
cytosar - u ®
sponge
nucleoside
dna polymerase
>50 / 711
cancer
fda - approved
vidarabine (ara - a)
vira - a ®
sponge
nucleoside
viral dna polymerase
0
antiviral
fda - approved
ziconotide
prialt ®
cone snail
peptide
n - type ca 2 + channel
2 / 5
analgesic
fda - approved
eribulin mesylate (e7389)
halaven ®
sponge
macrolide
s microtubule
19 / 27
cancer
fda - approved
omega - 3 - fatty acid ethyl esters
lovaza ®
fish
omega - 3 fatty acids
triglyceride - synthesizing enzymes
45 / 94
hypertriglyceridemia
fda - approved
trabectedin (et - 743) eu approved only
yondelis ®
tunicate
alkaloid
minor groove of dna
17 / 34
cancer
phase iii
brentuximab vedotin (sgn - 35)
adcetris ®
mollusk
antibody - drug conjugate (mm auristatin e)
cd30 and microtubules
9 / 19
cancer
clinical status
compound name
trademark
marine organism α
chemical class
molecular target
clinical trials β
disease area
phase iii
plitidepsin
aplidin ®
tunicate
depsipeptide
rac1 and jnk activation
1 / 7
cancer
phase ii
dmxba (gts - 21)
n / a
worm
alkaloid
alpha - 7 nicotinic acetylcholine receptor
0 / 3
congnition , schizophrenia
phase ii
plinabulin (npi 2358)
n / a
fungus
diketopiperazine
microtubules and jnk stress protein
1 / 2
cancer
phase ii
elisidepsin
irvalec ®
mollusk
depsipeptide
plasma membrane fluidity
1 / 2
cancer
phase ii
pm00104
zalypsis ®
nudibranch
alkaloid
dna - binding
2 / 3
cancer
phase ii
glembatumumab vedotin (cdx - 011)
n / a
mollusk
antibody drug conjugate (mm auristatin e)
glycoprotein nmb and microtubules
1 / 3
cancer
clinical status
compound name
trademark
marine organism α
chemical class
molecular target
clinical trials β
disease area
phase i
marizomib (salinosporamide a)
n / a
bacterium
beta - lactone - gamma lactam
20s proteasome
4 / 4
cancer
phase i
pm01183
n / a
tunicate
alkaloid
minor groove of dna
n / a
cancer
phase i
sgn - 75
n / a
mollusk
antibody drug conjugate (mm auristatin f)
cd70 and microtubules
2 / 2
cancer
phase i
asg - 5 me
n / a
mollusk
antibody drug conjugate (mm auristatin e)
asg - 5 and microtubules
2 / 2
cancer
phase i
hemiasterlin (e7974)
n / a
sponge
tripeptide
microtubules
0 / 3
cancer
phase i
bryostatin 1
n / a
bryozoa
polyketide
protein kinase c
0 / 38
cancer , alzheimers