Ghosh died on 25 March 2020 at a hospital in Kolkata from surgery-related problems, at the age of 85.
Jon Atle Gaarder
Jon Atle Gaarder (27 November 1934 – 14 March 2020) was a Norwegian diplomat. He was a counsellor for the Norwegian delegation to NATO from 1975 to 1979.
In 1984, Gaarder was named ambassador to Saudi Arabia, as well as representing Norway in the United Arab Emirates, Yemen and Oman. From 1990 to 1994, he was ambassador to India. During this time, he also represented Norway in Sri Lanka, Bangladesh, Bhutan, Nepal and the Maldives. In 1996, he became the ambassador to the Federal Republic of Yugoslavia. He was also Norway's representative in Bulgaria, Republic of Macedonia and Albania. He also served as the ambassador to Lithuania from 1999 to 2001.
Gaarder was born in Årnes, Hedmark and grew up in Skarnes. He died on 14 March 2020 at the age of 85.
Kåre Dæhlen
Kåre Dæhlen (born 23 October 1926) is a Norwegian diplomat. He started working for the Norwegian Ministry of Foreign Affairs in 1955. He served as the Norwegian ambassador to Greece (1974–1976), Poland (1981–1986), India (1986–1990) and Austria (1990–1994).
Phil Phillips
John Philip Baptiste (March 14, 1926 – March 14, 2020), better known as Phil Phillips, was an American singer and songwriter. He is best known for his 1959 song, "Sea of Love". The song went to No. 2 in the US "Billboard" Hot 100 pop chart. It also spent 14 weeks in the top 40, as well as reaching No. 1 on the R&B chart. In 1959, it sold over one million copies and was awarded a gold disc. The single has had notable covers by Del Shannon (which reached No. 33 on the pop chart in 1982), the Honeydrippers (which peaked at No. 3 spending 14 weeks in the top 40 in 1984) and Tom Waits. Phillips' version was featured most notably in the movie "Sea of Love" (1989), starring Al Pacino.
Phillips was born in Crowley, Louisiana. He was married and had seven children. On March 14, 2020, Phillips died on his 94th birthday in Lake Charles, Louisiana.
Antiviral drug
Viruses are the ultimate expression of parasitism. They not only take nutrition from the host cell but also direct it metabolic machinery to synthesize new virus particles. viral chemotherapy was considered impossible, as it would require interference with cellular metabolism in the host.
1. Anti-Herpes virus : idoxurudine, trifluridine, Acyclovir, valacyclovir, Famciclovir, Ganciclovir, Valganciclovir, Cidofovir, Foscarnet, Fomivirsen
2. Anti-Influenza virus: Amantadine, rimantadine, Oseltamivir, Zanamivir
3. Anti-Hepatitis virus/nonselective antiviral drugs Primarily for hepatitis B: Lamivudine, Adefovir dipivoxil, Tenofovir Primarily for hepatitis C: Ribavirin, Interferon α
4. Anti retrovirus:
(A) neucleoside rivers transcriptas inhibitor: Zidovudine
Didanosine, Stavudine, lamivudine, Abacavir, Emtricitabine, Tenofovir
(B) nonnucleoside reverse transcriptase inhibitors (NNRTIs): Nevirapine, Efavirenz, Delavirdine
(C) Protease inhibitors: Ritonavir, Atazanavir, Indinavir, Nelfinavir, Saquinavir, Amprenavir
(D) Entry (Fusion) inhibitor: Enfuvirtide
(E) CCR5 receptor inhibitor: Maraviroc
(F) Integrase inhibitor: Raltegravir
This deoxiguanosine analogue antiviral drug requires a virus specific enzyme for conversion to the active metabolite that inhibits DNA synthesis and viral replication.
Acyclovir is  taken by the virus infected cells. Because of selective generation of the active inhibitor in the virus infected cell and its greater inhibitory effect on viral DNA synthesis, acyclovir has low toxicity for host cells: a several hundred-fold chemotherapeutic index has been noted.
Only about 20% of an oral dose of acyclovir is absorbed. It is little plasma protein bound and is widely distributed attaining CSF concentration that is 50% of plasma concentration. After topical application, it penetrates cornea well. Acyclovir is primarily excreted unchanged in urine, both by glomerular filtration and tubular secretion; plasma t½ is 2–3 hours.
Chemically, it is a unique tricyclic amine unrelated to any nucleic acid precursor, but inhibits replication of influenza A virus. the activity of amantadine is strain specific, influenza b is not affected. H5N1 and H1N1 strains of Influenza A are resistant in most areas. it appears to act an early step (possibly uncoating) as well as at a late step (viral assembly) in viral replication. protein designated M2 which acts as an Ion channel has been identify as one of is targets of action. Resistance to amantadine develops by mutation causing amino acid substitutions in the M2 protein.
Nausea, Anorexia, Insomnia, Dizziness, Nightmares, Lack of mental concentration, Rarely Hallucinations have been reported. Ankle edema occurs due to local vasoconstriction.
α Interferons (IFNs)are low molecular weight glycoprotein cytokines produced by host cells in response to viral infections, TNFα, IL-1 and some other inducers.
They have nonspecific antiviral activity as well as other complex effects on immunity and cell proliferation. interferons binds to a very specific cell surface receptors and affect its replication at multiple steps,  viral penetration, synthesis of viral mRNA, assembly of viral particles and their release, but the most widespread effect is direct or indirect suppression of viral protein synthesis, i.e. inhibition of translation. interfeorn receptor like JAK STAT tyrosine protein kinase receptors which on activation phosphorylate cellular proteins. These then migrate to the nucleus and induce transcription of ‘interferon-inducedproteins’ which exert antiviral effects
Antiviral drugs are a type of drug used for treating viral infection. Most antivirals are used for specific viral infections, while a broad-spectrum antiviral works against a wide range of viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen (something that causes disease); instead they stop their development.
Antiviral drugs are a type of antimicrobials, a larger group which also includes antibiotic (also called antibacterial), antifungal and antiparasitic drugs, or antiviral drugs based on monoclonal antibodies. Most antivirals do not cause much damage to the body, and can be used to treat infections. They are different from viricides, which are not medicine but deactivate or destroy virus particles inside or outside the body. Natural antivirals are made by some plants such as eucalyptus and Australian tea trees.
all drugs mechanism of action by uvmedicine.store
Viktor Josef Dammertz
Viktor Josef Dammertz (8 June 1929 – 2 March 2020) was a German bishop of the Roman Catholic Church. He was born in Schaephuysen, Rheurdt. He became a priest in 1957. He served as bishop of Augsburg from 1993 until his retirement in 2004.
Dammertz died on 2 March 2020 in Eresing, at the age of 90.
Viral infection
A viral infection (or viral disease, or infectious disease) occurs when a living thing's body is entered in an unwanted way by disease-causing viruses, and able to be caught from others virus particles (virions) attach to and enter susceptible cells.
Basic structural features, such as genome type, virion shape and replication site, generally share the same features among virus species inside the same family.
Animaniacs (2020 TV series)
Animaniacs is an American animated series made Wellsley Wild and Steven Spielberg. It first started showing on Hulu in 2020. It is a revival of the 1993 television show "Animaniacs".
Notes
Soundaraj Periyanayagam
Soundaraj Periyanayagam (6 June 1949 – 21 March 2020) was an Indian bishop of the Roman Catholic Church. He was born in Periya Kozhappalur. He became a priest in 1983. He served as bishop of Vellore from 2006 until his death in 2020.
Periyanayagam died on 21 March 2020 in Chetpet, Tamil Nadu, at the age of 69.
Antimicrobial