From February to August 2010, Taeyeon became a presenter for the KBS 2TV show, "Win Win", alongside Wooyoung of 2PM, Choi Hwa-jung, Kim Shin-soung and Kim Seung-woo. On May 7 of the same year, she had her musical debut as interpreting the main role in "Midnight Sun", which is based on the Japanese novel "Taiyō no uta" by Aya Denkawa. The musical was about Kaoru Amane, a 17-year-old girl who she suffers from xeroderma pigmentosa, which forbids her from going out during the day. She maintains her hopes for writing songs and singing every night at a train station; Taeyeon received good reviews for her performance. She also learned to play the guitar for her performance. Reflecting on her experience, Taeyeon stated that the musical was difficult for her, citing that her weak concentration made her act and sing at the same time. It was difficult for her. Taeyeon released a song, "Like A Star", accompanied by his former trainer The One, as well as a solo song, "I Love You," for the SBS drama, "Athena: Goddess of War". The previous song reached number one on Gaon's digital list. The previous song reached number one on the digital list of Gaon42 and the last reached the second place.
In 2011, Taeyeon made a duet with Kim Bum-soo, singing "Different". The song won second place in Gaon. The two singers met again at a concert two years later for another collaboration entitled "Man and Woman".
Taeyeon and her bandmate, Seohyun, participated as voice actresses for the Korean versions of the films "Despicable Me" (2010) and its sequel "Despicable Me 2" (2013). They interpreted the voice of the characters of Margo and her sister, Edith, respectively. On March 28, 2012, after releasing the single "Missing You Like Crazy" for the melodrama of MBC, "The King 2 Hearts", the song peaked number two in Gaon and Korea K-Pop Hot 100 on "Billboard".
The singer had previously rejected the offer to sing the song due to the short time she had due to the schedule with Girls' Generation. However, she made a promise to the musical director, Lee Pil-ho, who would collaborate again after working with him on the soundtrack of "Beethoven Virus". He stated that he had not considered anyone other than Taeyeon to sing the song. The song was finally chosen as the most popular soundtrack of the year in 2012 Seoul Drama Awards. In the same year, another song, "Closer", for the SBS drama, "To The Beautiful You" was ranked number seven on several lists.
In May 2012, Taeyeon, along with two of her bandmates, Tiffany and Seohyun, formed the Girls' Generation-TTS (or TTS) sub-group, releasing their first EP titled, "Twinkle". The sub-group has a different concept and style from Girls' Generation placing its focus on the vocal capacity of each member, while the latter stands out in their songs and performances. The three members also became hosts to the MBC music program, "Show! Music Core", from February 2012 to April 2013.
In January 2013, Taeyeon returned to MBC as a guest DJ on the Shindong show, "Shimshimtapa", along with her bandmate Tiffany. The two singers also made a duet singing "Lost Love," which appeared on Girls' Generation Generation's fourth Korean album, "I Got a Boy".
On March 13, 2013, Taeyeon released the song "A One" for the SBS drama, "That Winter, the Wind Blows". Was ranked in the first place in Korea K-Pop Hot 100 and reached number two in the Gaon Digital Chart. The song was written and composed by Kangta, expressing the abundant emotions of an unfortunate love.
On July 9, 2013, Taeyeon lent her voice to the song "Bye" for the movie "Mr. Go". The song, this time, was not as successful on the music charts.
In February 2014, Taeyeon joined the ballad group, SM the Ballad, formed by S.M. Entertainment in 2010. In the second album, "SM the Ballad Vol. 2 - Breath", she did a duet with Jonghyun for the song "Breath" as well as her solo song "Set Me Free". "Breath" was the theme of Mnet's mini-drama, "Mimi". The song was also within the top 10 of Gaon and Korea K-Pop Hot 100.
In March 2014, Taeyeon recorded the song "Colorful" for the JTBC campaign, "The World Is More Beautiful Because We're Different".
On May 30, 2014, Taeyeon released the song "Love, That One Word" for the drama "You're All Surrounded" of SBS. The song has peaked the top ten in several lists. At mid-year, Taeyeon concentrated on her activities with the TTS sub-group. They released their second EP, "Holler", in September 2014; the album debuted in the first place of Billboard World Albums and Gaon Weekly Charts. Taeyeon took responsibility for the selection of the album's single. During the promotion period, the three singers performed on the reality show, "The TaeTiSeo". The show had a more personal and close side focusing on the three singers, revealing how they live their normal daily life. Taeyeon declared: "If it were not for the passionate members of Girls' Generation, I would not have had the opportunity to sing."
In February 2015, she participated in the music video of the song "Shake That Brass" by Amber Liu for her solo debut. Amber revealed that she personally asked Taeyeon if she could collaborate on the song.
In September 2015, Taeyeon released a new version of the song "Scars Deeper Than Love" in a duet with Yim Jae-beom.
In October 2015, Taeyeon debuted as a solo artist releasing her first EP titled "I". In that same month S.M. Entertainment, released a music video with the album's single. Her brother, Ji-woong, made a short appearance in the music video. Taeyeon also had her first titled concert, Tae-yeon's Very Special Day at SM COEX Artium.
In November 2015, she appeared in "If The World Was a Perfect Place," a song from Verbal Jint's sixth album.
On December 4, Taeyeon won an award as "Best Female Artist" in the Mnet Asian Music Awards. After the success of her first solo album, S.M. announced on December 18 that Taeyeon began preparing for a second album that was published in 2016.
On January 22, 2016, she appeared in "Don't Forget", a digital single from Crush. The single was well received, leading several musical lists. Following the success of her first solo album, "Rain", was released as a digital single to start the project, "SM Station", along with the release of a music video and accompanied by the single, "Secret" on 3 February 2016. "Rain" won her first win on the "Inkigayo" music show on February 14.
In April 2016, Taeyeon released a new version of the song "Blue Night of Jeju Island" for the mineral water of the Samdasoo brand. The song managed to head several music lists without making a promotion.
On May 13, 2016, it was announced that Taeyeon was selected as the promotion model for the MMORPG video game by Kakao, "Sword and Magic" and for the remake of the song "Atlantis Princess" by her labelmate BoA. She also held her first solo concert, Butterfly Kiss in Seoul, from 9 to 10 July and Busan, from 6 to 7 August.
After recording "All With You" for the drama "Moon Lovers: Scarlet Heart Ryeo" of SBS, released her next single, "", in November 2016. The song peaked at number two on Gaon Digital Chart and was chosen by Billboard as the seventh best K-pop song of the year. Auto-described the single as an easy song to listen to remember and remember the autumn, she later revealed an acoustic version of it on YouTube. With her work of 2016, she was honored by "The Dong-a Ilbo" as Voice of the Year, Singer of the Year and Most Hardworking Artist. She won for the second time the award for Best Female Artist at the 2016 Mnet Asian Music Awards.
After being in the production process for over a year, Taeyeon's first studio album, "My Voice", was released in February 2017, producing a single titled "Fine". Before the release of the album, a music video for the song "I Got Love" was released as a promotional song.