Class I MHC i can serve as an inhibitory ligand for natural killer cells (NKs). Reduction in the normal levels of surface class I MHC, a mechanism employed by some viruses and certain tumors to evade CTL responses, activates NK cell killing.These inhibitory receptors recognize MHC class I molecules, which could explain why NK cells kill cells with low levels of MHC class I molecules. This inhibition is crucial to the role played by NK cells. MHC class I molecules are main way cells display viral or tumor antigens to cytotoxic T-cells. A common evolutionary adaptation to this seen in both intracellular microbes and tumours is a long-term down-regulation of these MHC I molecules. This makes the cells impervious to T-cell action. NK cells may have evolved as an evolutionary response: the loss of MHC would deprive these cells of the inhibitory effect of MHC and make them vulnerable to NK cell attack.
The "adaptive" immune response generates memory cells after a primary infection. Then there is a rapid response to later infections by the same antigen. Earlier it was thought that NK cells play no role in the adaptive immune responses, but now it seems they do.
Juan Luna
Juan Luna y Novicio (October 23, 1857 — December 7, 1899) was a Filipino nationalist, painter, artist, sculptor and Revolution activist. A prominent artist, he has been called the Philippines' national painter.
Charles Fleischer
Charles Fleischer (born August 27, 1950) is an American stand-up comedian, actor, voice artist, and comedian. He is best known as the voice of Roger Rabbit in the "Who Framed Roger Rabbit" franchise.
From December 2010 to September 2011, Fleischer hosted his own web show called "Fleischer's Universe" on Ustream.tv.
Fleischer was born and raised in Washington, D.C. on August 27, 1950. He attended Southampton College of Long Island University, and studied acting at Chicago's Goodman Theatre.
Levant Fair
The Levant Fair (; "") was an international trade fair held near Tel Aviv Port in the 1920s and 1930s. It is also the nickname of the site where the fair was held.
Patrice Rushen
Patrice Rushen (September 30, 1954) is an American singer, composer and musician. She has had several hit songs. She is best known for the song "Forget Me Nots". She was born in Los Angeles, California.
John Joe Nevin
John Joseph "Joe" Nevin (born 7 June, 1989 in Mullingar, County Westmeath) is an Irish boxer. He competed in the 2008 Summer Olympics and the 2012 Summer Olympics and got a silver medal in the 2012 Summer Olympics. He is currently 3rd AIBA World Rankings - Men's 56 kg in the world in his division, the bantamweight. On 6th October, 2012, John Joe Nevin announces to the public on The Saturday Night Show that he is turning professional
The Stolen Eagle
"The Stolen Eagle" is the first episode of the HBO/BBC historical drama television series, "Rome". It first aired on August 28, 2005 in the United States. The episode starred Ciarán Hinds, Kevin McKidd, Ray Stevenson, and Polly Walker.
Cartoon Network Central &amp; Eastern Europe
Cartoon Network Central & Eastern Europe is the Czech-Hungarian-Romanian feed of Cartoon Network. The Cartoon Network broadcasts cartoons and sometimes live action television programs.
Institute for Research on Public Policy
The Institute for Research on Public Policy (IRPP; ) is Canada's oldest non-partisan public policy think tank.
The IRPP seeks to improve public policy in Canada. IRPP supports research and debate.
IRPP was founded in 1972 in Montreal.
Hospitality
Hospitality is about people welcoming other people into their homes or other places where they work or spend their time. People who welcome visitors are called hosts. The people they welcome are called guests.
The word "hospitality" comes from the Latin "hospes", which came from the word "hostis", which originally meant "to have power."
Hospitality is all about the art of entertaining or receiving guests. We talk about "offering hospitality". There are many different ideas about how to offer hospitality according to the various cultures in the world. In the past, many societies taught that it was always right to offer hospitality to strangers who came to their door in need of food or shelter. This may seem a strange idea to many of us today, but it was an important way to survive in many societies, especially in lands where people travelled long distances, often far away from large towns.
The words hospital, hospice, and hostel also come from the word "hospitality". They are all about giving personal care to people who are away from their homes.
The hospitality industry is service industry that includes hotel and restaurant workers.
Grand Teton National Park
Grand Teton National Park is a national park in the United States. It is south of Yellowstone National Park. Both of these parks are located in Wyoming.
The park's namesake mountain, Grand Teton, is popular for mountain climbing.
Herero and Namaqua genocide
The Herero and Namaqua Genocide is thought to have been the first genocide of the 20th century. It took place between 1904 and 1907 in German South-West Africa (today called Namibia), during the scramble for Africa.
On January 12, 1904, the Herero people, led by Samuel Maharero, fought back against German colonial rule. In August, German general Lothar von Trotha defeated the Herero in the Battle of Waterberg and drove them into the desert of Omaheke, where most of them died of thirst. In October, the Nama people also fought against the Germans only to suffer a similar fate.
In total, from 24,000 up to 100,000 Herero and 10,000 Nama died. The genocide was marked by many deaths by starvation and thirst because the Herero who fled the violence were not allowed to go back to the Namib Desert. Some sources also claim that the German colonial army normally poisoned desert wells.
In 1985, the United Nations' Whitaker Report said that the aftermath was an attempt to exterminate the Herero and Nama peoples of South-West Africa, and said it was one of the first tries at genocide in the 20th century. The German government said that the genocide happened and said sorry for the events in 2004, but did not give compensation to the victims' relatives.
Stubby Kaye
Stubby Kaye (November 11, 1918 – December 14, 1997) was an American actor and comedian.
Kaye was born Bernard Kotzin in New York City, New York on November 11, 1918. He was raised in Far Rockaway, Queens and in The Bronx.
Taraji P. Henson
Taraji P. Henson (born September 11 1970) is an actress who has been featured in many movies. She played Shug in the movie "Hustle and Flow". She later played Queenie in "The Curious Case of Benjamin Button".
Henson was born near Washington, D.C..
Bear Grylls
Edward Michael "Bear" Grylls (born 7 June 1974) is an English-Irish adventurer. He has been the Chief Scout since 2009. He climbed Mount Everest when he was 23. He broke the record for the youngest British person to climb the mountain. Grylls has been in many television programmes.
Grylls was born in London and grew up in Donaghadee, County Down and Bembridge, Isle of Wight. He was educated at Eton College and Birkbeck, University of London.
He served in the S.A.S. and is a Christian.
His wife is Shara Cannings Knight and his parents are the late Conservative MP Sir Michael Grylls and Lady Grylls (she is of Irish origin).
Baek A-yeon
Baek Ah-yeon (Hangul : 백아연, born on March 11, 1993) is a South Korean solo singer who debuted in JYP Entertainment. She is known as the third finalist of South Korea's talent show, K-Pop Star.
A-yeon was born on March 11, 1993. She was one of a popular talent show contestants, K-Pop Star which the judges was the big three (SM, YG, JYP). She studied at the Department of Practical Music at Howon University.
Huronian glaciation
The Huronian glaciation (or Makganyene glaciation) lasted from 2400 million years ago (mya) to 2100 mya, during the Paleoproterozoic era.