In the United States, urinary tract infections lead to nearly seven million office visits, a million emergency department visits, and 100,000 hospitalizations every year. The cost of these infections is high due to both lost time at work and costs of medical care. The direct cost of treatment is estimated at 1.6 billion USD yearly in the United States.
Urinary tract infections have been described since ancient times. The first written description, found in the Ebers Papyrus, dates to around 1550 BC. The Egyptians described a urinary tract infection as "sending forth heat from the bladder." Herbs, bloodletting, and rest were the common treatments until the 1930s, when antibiotics became available. Sulphonamides became available around 1935.
Pregnant women with UTIs have a higher risk of kidney infections.During pregnancy, high progesterone (a hormone) levels decreased muscle tone of the ureters and bladder. Decreased muscle tone leads to a greater likelihood of reflux, where urine flows back up the ureters and toward the kidneys. If bacteria are present, pregnant women have a 25-40% risk of a kidney infection. Thus treatment is recommended if urine testing shows signs of an infection—even in the absence of symptoms. Cephalexin or nitrofurantoin are typically used because those medications are generally considered safe in pregnancy. A kidney infection during pregnancy may result in premature birth or pre-eclampsia (a state of high blood pressure, kidney dysfunction, or seizures).
Thumbelina
"Thumbelina" () is a fairy tale by Hans Christian Andersen.
The tale was first printed by C. A. Reitzel on 16 December 1835 in Copenhagen, Denmark. "Thumbelina" is about a tiny girl. She has several adventures with a toad, a mole, a field mouse, and other creatures of field and forest. At the end, she meets and falls in love with a flower-fairy prince just her size.
"Thumbelina" was one of nine fairy tales Andersen printed between 1835 and 1837 in a series of three booklets. These booklets were called "Fairy Tales Told for Children". "Thumbelina" appeared in the second booklet with "The Naughty Boy" and "The Traveling Companion". The first booklet included "The Tinderbox", "Great Claus and Little Claus", "The Princess and the Pea", and "Little Ida's Flowers". The third booklet was printed in 1837. Only two tales, "The Little Mermaid" and "The Emperor's New Clothes", appeared in the third and final booklet.
"Thumbelina" is completely Andersen's invention. He did however know tales about tiny people such as "Tom Thumb" and the six-inch tall Lilliputians in "Gulliver's Travels". He may have taken some inspiration from these tales. Andersen's tales were not liked by the Danish critics. They did not like their casual style and their lack of morals. One critic liked "Thumbelina". He called it "delightful". The tale has been adapted to an animated movie and a live-action television programme.
A woman wants a baby. She asks a witch to help her. The witch gives the woman a barleycorn. She tells the woman to plant it, and wait for what will happen. The barleycorn is planted, and a flower grows. When the woman kisses the flower, it pops open to reveal tiny Thumbelina.
One night, Thumbelina is asleep in her walnut-shell cradle. She is carried off by a toad who hops through an open window. The toad wants the tiny girl as a bride for her son. She puts Thumbelina on a lily pad for safekeeping. Thumbelina escapes the toad with the help of friendly fish and a white butterfly. She floats away on the lily pad.
She is suddenly snatched and carried away by a cockchafer (beetle). The beetle's friends are proud and arrogant. Thumbelina is not of their social class. They take a dislike to her at once. The beetle drops her without a second thought, and flies away.
Thumbelina lives alone as best she can in the fields. When winter comes, she needs to find a place to live. She is finally given a home by an old field mouse. Thumbelina thanks the mouse by taking care of her little house.
The mouse thinks Thumbelina should marry her neighbor, a smart and well-to-do mole. Thumbelina finds the idea of being married to such a creature hateful. After all, he spends all of his days underground and never sees the sun or sky.
The field mouse does not listen to Thumbelina's protests. She continues to urge the marriage. At the last minute, Thumbelina flies away with a swallow to a far, sunny land. Thumbelina brought the swallow back to health during the winter. They have been friends ever since.
The swallow carries Thumbelina to a sunny land. In a field of flowers, Thumbelina meets a tiny flower-fairy prince just her size and to her liking. They wed. Her husband gives her a pair of wings so she can fly with him on his travels from flower to flower. She is given a new name, Maia.
In the last page of the story, the swallow has flown to a poet's window, and tells him the complete story of Thumbelina.
"Note:" Mary Howitt was the first to translate the story into English. She disliked the encounter with the witch. In her translation, she starts the tale with a beggar woman giving a peasant's wife a barleycorn in exchange for food. Once the barleycorn is planted, tiny Thumbelina (Tommelise) emerges from its flower.
Hans Christian Andersen was born in Odense, Denmark on 2 April 1805. His father was Hans Andersen, a shoemaker. His mother was Anne Marie Andersdatter, a laundress. Andersen was an only and a spoiled child. He shared a love of books with his father. His father read him "The Arabian Nights" and the fables of Jean de la Fontaine. Together, they built panoramas, pop-up pictures, and toy theatres. Father and son took long walks into the countryside.
Andersen's father died in 1816. From then on, Andersen was on his own. Andersen was a tall, thin boy who was bullied by other boys. He wanted to escape them, and his poor, illiterate mother. He advertised his artistic talents to the middle class of Odense. He sang and danced in their homes. On 4 September 1819, the fourteen-year-old Andersen left Odense for Copenhagen with gifts of money he had received from his neighbors. He carried a letter of reference to the ballerina Madame Schall, and had dreams of becoming a poet, a ballet dancer, or an actor.
After three years in Copenhagen without someone to support him, Andersen finally found an interested gentleman in Jonas Collin, the director of the Royal Theatre. Collin believed in the boy's talents. He managed to have the king send Andersen to a grammar school in Slagelse, a country town in west Zealand. He thought Andersen would continue his education at Copenhagen University at the right time.
At Slagelse, Andersen was taught by the short, fat, balding thirty-five-year-old Simon Meisling. This man was interested in Ancient Greece and Rome, and had translated Virgil's "Aeneid". Andersen was not the brightest student in his class, and Meisling gave Andersen his sharp disapproval. "You're a stupid boy who will never make it," Meisling told him. Meisling is believed to be the model for the learned mole in "Thumbelina".
Fairy tale and folklore researchers Iona and Peter Opie believe that "Thumbelina" is a "distant tribute" to Andersen's friend, Henriette Wulff, the small, delicate, handicapped daughter of the Danish translator of Shakespeare. She loved Andersen as Thumbelina loves the swallow; however, there is no written evidence to support the "distant tribute" theory.