If the addiction keeps on going, eventual permanent brain changes can appear, which eventually adapts to the drug’s presence. Both prescription and recreational users of Opioids find that they will have to take increasingly larger doses of the drug to get the same effects, a process known as developing a tolerance. As users take greater and greater amounts of Opioids, they become progressively dependent on them. At this point, a full-blown addiction has developed. Even patients who experience chronic pain may be at risk for addiction, even though they are prescribed Opioids for treatment.
Analgesic
Analgetics (one "analgetic") (or analgesics) is a word for some drugs that are used to stop pain. These are also known as painkillers. There are several kinds of painkillers. All act on the nervous system. Some painkillers (such as opioids) can make people addicted if they are taken for a long time. Some painkillers have side effects that can harm people when they take too much (e.g., too much paracetamol can be dangerous for the liver)
Blender (program)
Blender is a free, open source 3D computer graphics program. It is available for many operating systems, for example Microsoft Windows, macOS and Linux. It is made by the Blender Foundation. It was used, for example, to make the short movies Elephants Dream, Big Buck Bunny and Sintel.
A Dutch animation studio called NeoGeo created Blender as an in-house application. The song Yello, which is from a song album called Baby, started an idea of the name "Blender". Ton Roosendaal founded NaN in June of 1998. He wanted to make and show off the program to the public. The program was published as shareware until NaN went bankrupt in 2002. The creditors, people who have other people oweing money to them, agreed to sell out Blender under the laws of the GNU General Public License in exchange for a one-time payment of 100,000 Euros (102,000 in U.S. dollars.) On July 18, 2002, Roosendaal put money into a Blender funding campaign—in order to collect donations. On September 7, 2002, the collected funds was given notice to the public. This proved that the Blender source code would be published. Blender is now an open source program. Right now, the Blender Foundation watches and takes care of it. It is the Blender Foundation's responsibility to do such a thing. The Blender Foundation have the right to use dual licensing, so that, in addition to GNU GPL, Blender would also have the permission to use the following name: "Blender License". Blender License does "not" have a rule that says it needs a disclosing source code but it "does" have a rule on payments to the Blender Foundation. On the other hand, this choice was never used and became null in 2005. Right now, Blender belongs only to GNU GPL.
Blender has many features and tools, such as:
Mark Shuttleworth
Mark Richard Shuttleworth (born 18 September 1973) is a South African business person. He was the first African in space. He bought himself his space travel. He is also the leader of the Ubuntu project.
Paracetamol
Paracetamol (or acetaminophen) is a common analgesic, a drug that is used to relieve pain. It can also be used to reduce fever, and some kinds of headache. This makes it an antipyretic, something that reduces fevers. It is used in many drugs that treat the flu and colds.
The words "acetaminophen" and "paracetamol" both come from the names of the chemicals used in the compound: N-acetyl-para-aminophenol and para-acetyl-amino-phenol. Sometimes, it is shortened to APAP, for N-acetyl-para-aminophenol.
Harmon Northrop Morse was the first to make Paracetamol, in the year 1878. Drugs made with Paracetamol became common in the 1950s. Today, these drugs are some of the most used, together with those containing salicylic acid or Ibuprofen. In the year 1977, Paracetamol was put on the List of Essential Medicines of the WHO.
Paracetamol is considered safe for use. The drug is easily available without a prescription. People often take too much Paracetamol. Sometimes this is because people do not know how much they should take. The recommended dose may not work for some individuals. Other times it is because they are trying to commit suicide. Very often, a person's liver can be hurt if he or she takes too much Paracetamol. A dose of 150 milligrams for every kilogram of the person's weight (about 10 grams for most adults) will lead to permanent liver damage, and may cause the liver to fail. For people whose livers have already been damaged, such as alcoholics, and for those with a limited secretion of Paracetamol, this amount can be much smaller.
In England and Wales, about 30.000 people per year go to the hospital after taking too much paracetamol (called paracetamol poisoning), and about 150 die of the poisoning. Since a law was passed saying that Paracetamol packets cannot be too large, fewer people have been committing suicide with Paracetamol. In Great Britain and the United States Paracetamol is the main reason for acute liver failure. About half of the cases are because of an 'unintentional overdose'.
Morphine
Morphine (INN) (IPA: ) is a strong opiate pain killer drug. It is the principal active agent in opium and the prototypical opiate. Like other opioids, e.g. "diacetylmorphine" (heroin), morphine acts directly on the central nervous system (CNS) to relieve pain, and at synapses of the nucleus accumbens in particular. Morphine is highly addictive when compared to other substances, and tolerance and physical and mental dependences develop very rapidly.
Patients on morphine sometimes say they have insomnia, visual hallucinations and nightmares; if these occur then reduction in dosage or switch to an alternative opioid analgesic should be considered.
The word "morphine" is derived from Morpheus, the god of dreams in Greek mythology. He is the son of Hypnos, god of sleep.
Morphine is used legally:
Ségolène Royal
Marie-Ségolène Royal (born September 22, 1953 in Dakar, French West Africa, now Senegal) is a French politician. She is the president of the Poitou-Charentes region, a member of the National Assembly and a prominent member of the Socialist Party in France. She was the Socialist Party's candidate for the 2007 French presidential election but lost to Nicolas Sarkozy. She was the partner of former President of France François Hollande from 1978 until 2007.
She is known for her admiration for some "Third Way" policies, for her controversial insistence on law and order issues and for her support of devolution and participatory democracy.
Royal is the author unless otherwise noted.
Codeine
Codeine or methylmorphine is an opiate used for its analgesic properties. It is also used to treat coughing and diarrhea. It is marketed as the salts codeine sulfate and codeine phosphate. Codeine hydrochloride is more commonly marketed in continental Europe and other regions.
Codeine is an alkaloid found in opium in concentrations ranging from 0.3 to 3.0 percent. Codeine can be extracted from opium. Today, most codeine is synthesized from morphine through the process of O-methylation.
Codeine is used to treat the following:
Codeine is often marketed as drugs in combination with paracetamol (acetaminophen) as co-codamol (best known in North America as Tylenol 3). Research has shown the combination to be very much more effective than paracetamol, and much less addictive that pure codeine.
There are similar combinations with aspirin as co-codaprin or with ibuprofen. These combinations provide greater pain relief than either agent alone. Drug synergy is an important principle.
Opium