The following day, the news media including local journalist Debbie Salt (Laurie Metcalf), descend on Windsor College where Sidney Prescott (Neve Campbell) and her brother Jerry Prescott (Matthew Lillard) and Jerry's friend Tom Scott (Dax Shepard) now study alongside their best friend Hallie (Elise Neal) and Sidney's new boyfriend Derek (Jerry O'Connell), fellow Woodsboro survivor Randy Meeks (Jamie Kennedy), and Derek's best friend Mickey (Timothy Olyphant). Sidney receives prank calls but is oblivious to the recent killings until someone instructs her to watch the news. Two other Woodsboro survivors arrive at the campus: officer Dwight "Dewey" Riley (David Arquette) to help Sidney, Jerry and Tom and reporter Gale Weathers (Courteney Cox) to cover the case. Gale tries to stage a confrontation between Sidney, Jerry, Tom and Cotton Weary (Liev Schreiber), who is attempting to gain fame from his exoneration for the murder of Sidney and Jerry's mother. After Gale forcibly confronts Sidney, Jerry and Tom with Cotton, Sidney angrily hits Gale and Jerry angrily scolds at Sidney for hitting Gale.
Later that evening, Sidney, Jerry and Tom go to a party with Hallie. At a sorority house, Ghostface murders fellow student Cici Cooper (Sarah Michelle Gellar). After all the partygoers leave, the killer then crashes the party and attack Sidney, Jerry and Tom, though Derek intervenes. The killer injures Derek but Dewey and the police arrive, prompting the killer to flee. The next morning, Gale discusses the case with the police. Upon realising that Cici's real name is Casey, she concludes that the killer is a copycat who targets students who share the same names as the Woodsboro murder victims, as Maureen Evans has the same name as Maureen Prescott, Phil Stevens as Steve Orth, Hugh Daniels as Dan Williams and Casey Cooper as Casey Becker.
That afternoon, while Gale is talking to Dewey, Tom and Randy on the campus lawn, she receives a call from Ghostface hinting that he is watching them. They search for him, but Randy, who tries to keep the killer on the phone, is dragged into Gale's broadcast van and is murdered by Ghostface. As night falls, Dewey and Gale review the tape of Ghostface killing Randy hoping to find some clues but the killer attacks them and seemingly kills Dewey. Gale hides and eventually escapes.
In the wake of the escalating murders, two officers drive Sidney, Jerry, Tom and Hallie to a local police station, but the killer murders them. In the ensuing struggle, Ghostface is knocked unconscious. After they climb out of the car, Sidney, Jerry and Tom insist on unmasking him, while Hallie insists they escape. When Sidney, Jerry and Tom walk back to the car, they see that Ghostface has escaped, who then stabs Hallie to death, forcing Sidney, Jerry and Tom flee.
Sidney, Jerry and Tom go back to the campus and find Derek in the auditorium tied to a crucifix, his mouth gagged with duct tape. Once Sidney, Jerry and Tom untie him, they is confronted by Ghostface, who reveals himself as Mickey and tells Sidney, Jerry and Tom that Derek is his partners. Derek desperately tries to persuade Sidney, Jerry and Tom that he is innocent and while Sidney, Jerry and Tom are deciding who is telling the truth, Mickey kills Derek. Mickey details his plan to become famous in the ensuing trial and media spectacle. He then announces his real partner, Debbie Salt, who arrives holding Gale at gunpoint. Sidney, Jerry and Tom recognise that Salt is actually Billy Loomis' mother, seeking revenge for her son's death. Mickey explains that they met online and agreed that Mrs. Loomis pays for Mickey's tuition fee while Mickey does the actual killing. Mrs. Loomis betrays Mickey and shoots him, as she plans to blame the murders on Mickey. Before he collapses, Mickey accidentally shoots Gale, causing her to fall off the stage, Sidney, Jerry and Mrs. Loomis fight, during their fight Mrs. Loomis shoots Tom in the stomach, killing him, until Cotton intervenes and eventually shoots Mrs. Loomis in the throat. As they debate whether or not she is still alive, they find Gale still alive. Mickey suddenly jumps to his feet, trying to attack them, only to be shot death by Sidney, Jerry and Gale. Sidney and Jerry then shoot Mrs. Loomis in the head to confirm her death, amd Jerry runs up to Tom and he gives Jerry some video tapes of he, Jerry, Dan, Sidney, Tatum, Billy, Stu, Randy, Cici, Martha, Jerry's old friends: (Justin Wilson, Douglas Harris, Karen James) and Sidney and Jerry's brother Steve, then Tom slowly dies, and Jerry cries over Tom's body. When the police arrive the next morning, Gale finds Dewey badly injured but still alive and accompanies him and Tom to the hospital. Sidney and Jerry instruct the press to direct questions to Cotton, rewarding him with the fame he has been chasing while removing the attention from herself as she and Jerry leave the university campus. A week later at Tom's funeral, Sidney and Jerry stand near Tom's grave.
Luke Wilson and Heather Graham cameo as actors in the in-universe "Stab" film. Tori Spelling and Donovan Patton appears as themselves, and Joshua Jackson cameos as one of Randy's classmates.
DNA repair
DNA repair means the processes by which a cell identifies and corrects damage to its DNA molecules.
In cells, normal metabolic activities and environmental factors such as UV light and radiation damage DNA. There are as many as a million molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the affected gene. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it divides. The DNA repair process must be constantly active so it can respond rapidly to any damage in the DNA structure.
The rate of DNA repair depends on many factors, including the cell type, the age of the cell, and the extracellular environment. A cell that has accumulated a lot of DNA damage, or one that no longer effectively repairs damage, can enter one of three states:
The rate of DNA repair depends on many factors, including the cell type, the age of the cell, and the extracellular environment. Many genes that were initially shown to influence life span have turned out to be involved in DNA damage repair and protection.
DNA damages and mutation are fundamentally different.
Although different from each other, DNA damages and mutations are related because DNA damages often cause errors of DNA synthesis during replication or repair; these errors are a major source of mutation. DNA damages in frequently dividing cells, because they give rise to mutations, are a prominent cause of cancer. In contrast, DNA damages in infrequently dividing cells are likely a prominent cause of aging.
The 2015 Nobel Prize for Chemistry went to three scientists who each discovered part of the DNA repair story.
Armiger
A person who has a coat of arms is sometimes called an "armiger". They are armigerous.
Originally an armiger was an Armour-Bearer or Esquire, who helped a Knight, but who had his own coat of arms.
The term "armiger" is well-defined only in countries such as the United Kingdom, Canada, Ireland, and Spain where there is a state or other heraldic body. These bodies include the College of Arms in England, Wales, and Northern Ireland, the Office of the Chief Herald in the Republic of Ireland or the Court of the Lord Lyon in Scotland).
Someone can have a coat of arms either because they are descended from a person with a right to bear a coat of arms, or by having a new "grant of arms" to him or herself.
Genome
The genome of an organism is the whole of its hereditary information encoded in its DNA (or, for some viruses, RNA). This includes both the genes and the non-coding sequences of the DNA.
Professor Hans Winkler coined the term in 1920.
Winkler's definition, in translation, runs: