Kornberg made the discovery that signals to the RNA are made by a complex of proteins that they called "mediator". The Nobel Prize committee said, "the great complexity of eukaryotic organisms is enabled by the fine interplay between tissue-specific substances, enhancers in the DNA and mediator. The discovery of mediator is therefore a true milestone in the understanding of the transcription process".
After long effort, Kornberg was able to use X-ray crystallography to take 3D pictures of RNA molecules, lipids and proteins. With these studies, Kornberg has created a picture of how DNA works. The Nobel Prize committee said, "the truly revolutionary aspect of the picture Kornberg has created is that it captures the process of transcription in full flow. What we see is an RNA-strand being constructed, and hence the exact positions of the DNA, polymerase and RNA during this process".
In 1959, Roger Kornberg's father, Arthur Kornberg, received the Nobel Prize in Physiology or Medicine for studies of how genetic information moves from one DNA molecule to another. This is called DNA replication. Arthur Kornberg found the first enzyme that could make DNA. This was the first known enzyme to take its instructions from a DNA copy. Roger Kornberg's younger brother, Thomas Bill Kornberg, discovered DNA polymerases II and III in 1970 and is now a geneticist at the University of California, San Francisco. All three Kornbergs have worked to understand how genetic information is used in cells. Arthur and Roger Kornberg are the sixth father and son to win Nobel Prizes.
Professor Kornberg has received these awards:
All We Know Is Falling
All We Know Is Falling is the first album of the band Paramore. It was recorded in just three weeks. In April 2006, the CD was released in the UK. In 2005, a Japanese version was released, with the bonus track "O, Star".
Paramore released three videos from this album. The first was for the single "All We Know", followed by "Pressure", and "Emergency".
Businessperson
A businessperson (also businessman or businesswoman) is someone who works at a job that focuses on making money. Very broadly it can mean anyone who works in industry or commerce. More narrowly, it is someone who works in the management (at high level, when the term is used even more narrowly) of a company. Sometimes the word means an entrepreneur or a merchant.
Many businessmen wear standard business clothes: a suit with collar, shirt, and necktie. However, this depends on the company, the local culture, and the country. In more informal places, neckties need not be worn.
Businesswomen clothes have gone through many changes. Dresses and suits are common today.
Werl
Werl is a town found in the district of Soest in North Rhine-Westphalia, Germany.
Werl is made up of the following districts:
Werl was the birthplace of Franz von Papen (1879–1969), German soldier, politician and diplomat.
Tangent (geometry)
In geometry, a tangent is a straight line that touches a curve at one point. At the place where they touch, the line and the curve both have the same slope (they are both "going in the same direction"). For this reason, a tangent line is a good approximation of the curve near that point. The curve and the tangent line are almost exactly the same near the intersection point.
A straight line which touches a circle at a single point is perpendicular to the circle's radius and is considered tangent to the circle.
Tangent lines are useful in calculus because they can magnify the slope of a curve at a single point. The slope of some curve at the point P is often called the instantaneous rate of change of the curve at P. The instantaneous rate of change at a specific point on the curve can be found by evaluating the derivative function for the curve at that point.
History of North America
The History of North America deals with an area where humans came to live relatively recently, compared to Africa, Europe, and Asia.
Scientists have different theories as to the origins of the early human population of the continent. The indigenous peoples of North America themselves have many creation stories, that tell that native Americans have been present on the land since its creation.
Before contact with Europeans the natives of North America were divided into many different communities, from small bands of a few families to large empires. They lived in several culture areas, which roughly correspond to geographic and biological zones of North America and give a good indication of the main occupation of the people who lived there (e.g. the Bison hunters of the Great Plains, or the farmers of Mesoamerica). Native groups can also be classified by their language family. It is important to note that peoples with similar languages did not always share the same material culture, nor were they always allies.
Scientists believe that the Inuit people of the high Arctic came to North America much later than other native groups, as evidenced by the disappearance of Dorset culture artifacts from the archaeological record, and their replacement by the Thule people.
During the thousands of years of native inhabitation on the continent, cultures changed and shifted. Archaeologists often name different cultural groups they discover after the site where they are first found. One of the oldest cultures yet found is the Clovis culture of modern New Mexico. A more recent example is the group of related cultures called the Mound builders (e.g. the Fort Walton Culture), found in the Mississippi river valley. They flourished from 3000 BC to the 1500s AD.
The more southern cultural groups of North America were responsible for the domestication of many common crops now used around the world, such as tomatoes and squash. Perhaps most importantly they domesticated one of the world's major staples, maize (corn).
As a result of the development of agriculture in the south, important cultural development was possible there. For example, the Maya civilization developed a writing system, built huge pyramids, had a complex calendar, and developed the concept of zero 500 years before anyone in the Old World. The Mayan culture was still present when the Spanish arrived in Central America, but political dominance in the area had shifted to the Aztec Empire farther north.
Upon the arrival of the Europeans in the "New World", native peoples found their culture changed drastically. As such, their affiliation with political and cultural groups changed as well, several linguistic groups went extinct, and others changed quite quickly. The name and cultures that Europeans recorded for the natives were not necessarily the same as the ones they had used a few generations before, or the ones in use today.
There was limited contact between North American peoples and the outside world before 1492. Several theoretical contacts have been proposed, but the earliest physical evidence comes to us from the Norse or Vikings. Norse captain Leif Erikson is believed to have reached the Island of Newfoundland circa 1000 AD. They named their new discovery Vinland. The only Norse site yet discovered in North America is at L'Anse aux Meadows, Newfoundland and Labrador. The Norse colonies were later abandoned.
The Viking voyages did not become common knowledge in the Old World, and Europeans remained ignorant of the existence of the Americas, until 1492. As part of a general age of discovery Italian sailor Christopher Columbus proposed a voyage west from Europe to find a shorter route to Asia. He eventually received the backing of Isabella I and Ferdinand II, Queen and King of newly united Spain. In 1492 Columbus reached land in the Bahamas.