translate English to French: A. Issues Relevant to Early Clinical Drug Trials Any discussion on appropriate use of placebo in clinical research and proposed guidelines cannot be separated from the parallel consideration of the experimental treatment – as there are risks involved with each. Thus, any proposed methodological, regulatory or institutional constraints on placebo use which could increase the exposure of subjects to experimental drugs should involve a careful and comprehensive risk/benefit evaluation.
A. Enjeux pertinents aux essais cliniques de phase II La discussion quant à l’utilisation du placebo en recherche clinique et sur les lignes directrices proposées ne peut être dissociée de la prise en compte du traitement expérimental, car tout deux J. B. Moseley, K. O'Malley, N. J. Petersen, T. J. Menke, B. A. Broday, D. H. Kuykendall, J. C. Hollingsworth, C. M. Ashton et N. P. Wray, «A controlled trial of arthroscopic surgery for osteoarthritis of the knee», NEJM, vol.