translate English to French: Increased incidence of neoplastic nodules in the liver in rats at ≥1120 mg/kgbw per day (diet); no increase in incidence of hepatic carcinomas (103 weeks) A marginal increase (statistically significant only at the low dose) in the incidence of hepatocellular adenomas and carcinomas combined in mice at ≥3200 mg/kg-bw per day (diet, 103 weeks) (NTP, 1986 / Huff et al., 1989) Lowest oral (diet) nonneoplastic LOEL (rat) = 2240 mg/kg-bw per day: thrombosis, degeneration of the liver, fibrosis of the spleen and lymphoid hyperplasia (NTP, 1986 / Huff et al., 1989) [Additional studies:
ComDeBDE/DeBDE DMEO non néoplasique la plus basse par ingestion (alimentaire) (rats) = 2 240 mg/kg p.c./jour : thrombose, dégénérescence du foie, fibrose de la rate et hyperplasie du tissu lymphoïde (NTP, 1986; Huff et al., 1989) [Autres études : Kociba et al., 1975a / 1975b / Norris et al., 1975a / 1975b / Dow Chemical Company, 1994] Négatif : moelle osseuse du rat (aberrations cytogénétiques), fonction hépatique du rat (dommage à l’ADN mesuré par élution alcaline) (Norris et al., 1975c; Kitchin et al., 1992; 1993; Kitchin et Brown, 1994)