Hyperkinetic circulation, as it is related to the clinical hypertensive diseases, is defined and its implications interpreted. These pathophysiological considerations have an important bearing in understanding the pressor mechanisms underlying hypertension and the application of therapy. Another very important consideration is the value of elucidating the mechanisms for the hyperdynamic circulation, for with a clearer understanding of these, we shall come closer to an explanation of the pathogenesis of hypertension.