jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Zeyu Ren | Liufan Wei | Shicheng Ren | Haitao Tang | Ying-Ming Pan
Source: Chemical Synthesis (article, 2026-04-02)
Field: Chemistry — Organic Chemistry

Atom-mutual-embedding strategy fuses four rings into rare tetrahexacyclic system Fuse (electrical) ; Set (abstract data type) ; Interchangeability ; Process (computing) ; Feature (linguistics) Synthesis and pharmacology of benzodiazepine derivatives ; Synthesis and Reactivity of Heterocycles ; Catalytic Cross-Coupling Reactions
Authors: Ante Markovina | Clara López-Iglesias | Ruiguang Cui | Daniel Klinger
Source: Refubium (Universitätsbibliothek der Freien Universität Berlin) (article, 2026-01-01)
Field: Chemistry — Organic Chemistry

Numerical estimation of drug loading contents in amphiphilic nanogels Amphiphilic nanogels (ANGs) are promising colloidal carriers to improve bioavailability of poorly water-soluble drugs. In contrast to conventional hydrophilic nanogels, ANGs contain additional hydrophobic domains in their network to load hydrophobic cargos. However, optimizing drug loading remains labour-intensive due to the lack of quantitative tools that accurately capture the complex ANG–drug interactions. To address this limitation and assess drug compatibility, we developed a quantitative framework based on Flory–Huggins interaction parameters ( χ ). Key to our approach is the empirical adjustment of the correction factor α to account for unequal contributions of dispersion forces, polar interactions, and hydrogen bonds. Using a model ANG and a library of hydrophobic drugs and dyes, we established selection rules for α based on the dominant interaction type: α = 1 for dispersion-dominated, α = 0.7 for polar, and α = 0.3 for hydrogen bond-dominated systems. This enabled systematic grouping of cargos and revealed strong monotonic negative correlations between adjusted χ values and experimental loading capacities. The resulting universal calibration curve links χ to drug loading content across diverse ANG–drug systems. Consequently, our framework suggests predictive potential of solubility parameter-based models, reduces experimental burden, and supports the rational design of ANG carriers tailored to specific hydrophobic drugs. Amphiphile ; Rational design ; Drug ; Drug delivery ; Dispersion (optics) ; Calibration ; Bioavailability ; Hydrophobic effect ; Drug carrier Surfactants and Colloidal Systems ; Hydrogels: synthesis, properties, applications ; Drug Solubulity and Delivery Systems
Authors: L Chen | Qiaohong Yao | Jie Chen | Yuxiang Peng | Jiao Xu | Qiang Fu
Source: Frontiers in Bioengineering and Biotechnology (article, 2026-01-07)
Field: Materials Science — Materials Chemistry

A dynamically tunable human serum albumin biosensor based on topological edge states graphene nanozyme This study presents a novel optical biosensor for human serum albumin (HSA) detection utilizing a heterostructure that integrates topological edge states with graphene. The sensor achieves high-sensitivity detection through optical topological modes and enables dynamic system responsiveness via graphene's tunable conductivity regulated by Fermi level modulation. Numerical results demonstrate that topological edge state excitation induces a sharp reflectance dip (depth >95%) at 195.5 THz in the optical communication band, exhibiting exceptional responsiveness to refractive index variations while maintaining stability against environmental interference through topological protection. Dynamic optimization is realized through electrostatic gating modulation of graphene's Fermi energy and layer number, with additional sensitivity enhancements achieved via precise control of sensing layer thickness and refractive index. The integration of topological photonics with two-dimensional materials provides a versatile foundation for developing sensing-therapeutic systems that address current challenges in biomedical applications, demonstrating significant potential for integration with nanozyme-based diagnostic and therapeutic nanotechnology. The platform's exceptional field enhancement and tunability could potentially augment the imaging sensitivity of nanozyme-based contrast agents, while its precise modulation capabilities may improve therapeutic efficiency through optimized catalytic activity. Furthermore, the robust topological protection mechanism offers enhanced stability crucial for clinical translation, addressing key limitations in current nanozyme technology including biocompatibility concerns and inconsistent catalytic performance. This integrated approach opens new possibilities for miniaturized, tunable, and interference-resistant biosensing systems with significant potential for multimodal synergistic applications in clinical diagnostics and environmental monitoring. Biosensor ; Graphene ; Photonics ; Topology (electrical circuits) ; Modulation (music) ; Fermi level ; Topological insulator ; Interference (communication) Carbon and Quantum Dots Applications ; Graphene and Nanomaterials Applications ; Advanced Nanomaterials in Catalysis
Authors: Gulbala Aleskerov | Yasin Suleymanli | Rugiya Askerova
Source: International Journal of Sustainability and Risk Control (article, 2026-03-07)
Field: Chemistry — Analytical Chemistry

The Rısks Assocıated wıth the Transportatıon of Hıgh Vıscosıty Oıls by Heatıng Most of the world's natural resources consist of ordinary and high-viscosity oil. High-viscosity and heavy oils can be transported by tanker, pipeline or rail. However, they lose their flowability at a certain temperature. Proper control of the movement of the contact zone of oil products is essential for successful sequential transportation. Increasing the temperature of crude oil reduces its viscosity and improves its flow during pipeline transportation. The rheological composition of the oil determines the efficiency of transportation in the main pipeline. Heavy oil contains high percentages of tar, paraffin and asphaltene. These components play an important role in increasing the oil's viscosity. One of the most popular methods involves the addition of chemical inhibitors to heating methods. The transportation of heavy and paraffinic oils by pipeline includes dilution and emulsification, as well as annular and main flow, and heating via thermal, electrical (direct or indirect), solar and thermochemical systems. However, the suitability of these techniques depends on the characteristics of the crude oil, new technological developments, and the results of feasibility studies. Although transporting high-viscosity oil by heating is technically and economically efficient, this process is accompanied by a number of serious risks. The most significant of these are fire and explosion hazards, mechanical damage to pipelines due to temperature stress, environmental pollution and energy loss. Therefore, high safety standards must be maintained when transporting oil by heating, and modern insulation and monitoring systems must be used. Only in this way can technical reliability and environmental safety be ensured. Pipeline transport ; Pipeline (software) ; Crude oil ; Dilution ; Process (computing) ; Heating oil ; Reliability (semiconductor) ; Pollution ; Viscosity Petroleum Processing and Analysis ; Drilling and Well Engineering ; Lubricants and Their Additives
Authors: Darina Zheleva | Desislava Angelova | Ekaterina Krumova | Lyudmila Yovchevska | Yana Gocheva
Source: Spanish Journal of Soil Science (article, 2026-01-19)
Field: Materials Science — Biomaterials

Investigation of ZnO Antimicrobial Surface Treatment of Shoe Lining Materials Prolonged wearing of shoes creates conditions for bacterial and fungal diseases. The use of nanotechnology and especially metal nanoparticles enables the production of high-quality leather for footwear with good antimicrobial properties. The pre-tanning process, which involves adding metal particles to the tanning solution, has been the subject of several studies on the application of metal oxides to leather. Few investigations have been conducted on the last finishing stage of leather nanoprocessing. The aim of the present study was to obtain and characterize the antimicrobial properties of finish films containing zinc oxide nanoparticles for shoe leather materials. The in situ method was applied to synthesize ZnO nanoparticles and these particles were deposited in a cross-linked collagen hydrogel applied to shoe lining materials. The obtained samples were examined by means of SEM, UV, FTIR and antimicrobial tests, and their properties were proven. Morphological analysis revealed the widespread presence of zinc oxide nanoparticles within the leather sample’s structure. Spectroscopic examinations highlighted the interactions between collagen in the leather tissue and gelatin on one side, while also detailing the bonds between inorganic particles on the other. The modified leather samples demonstrated a reduction in bacterial and fungal growth. The antimicrobial effectiveness varies depending on the type of modification and the specific bacterial strain tested. These finishes have been shown to serve as effective protective antimicrobial coatings for shoe leather materials, helping to safeguard the human foot from microbial exposure. Antimicrobial ; Zinc ; Nanoparticle ; Gelatin ; Fourier transform infrared spectroscopy ; Metal Collagen: Extraction and Characterization ; Dyeing and Modifying Textile Fibers ; Marine Biology and Environmental Chemistry
Authors: Myriam Reffay | Gilles Tessier | Jean-Francois Berret
Source: Nanoscale Advances (article, 2026-01-01)
Field: Materials Science — Biomaterials

Massart iron oxide nanoparticles in mechanobiology Magnetic nanoparticles (MNPs) derived from the Massart coprecipitation method have played a pioneering role in bridging materials science and biology. Their magnetic moment and nanoscale dimensions have long enabled applications in magnetic resonance imaging, targeted drug delivery, separation technologies, and hyperthermia. Beyond these well-established uses, a growing research direction has emerged at the interface of physics and biology: the application of MNPs in mechanobiology, the study of how mechanical forces regulate cellular and tissue functions. This review examines how Massart MNPs can be used to generate, transmit, and measure forces within living systems. Particular attention is given to interfacial control through advanced surface chemistries, which ensure colloidal stability, minimize toxicity, and preserve the nanoscale integrity of the particles. We also show that the robustness and scalability of Massart synthesis make it ideally suited to the production of biocompatible nanomaterials in quantities required for comprehensive biological studies. Two complementary approaches are discussed. The first exploits MNP assemblies that arise spontaneously within cells, in the form of endosomes. These compartments enable the application of controlled magnetic forces to study both the formation of reconstructed tissues and organoids, and their viscoelastic response. The second focuses on micrometric magnetic wires fabricated from MNPs, used in active microrheology to probe the cytoplasm of living cells over a wide frequency range. Together, these approaches illustrate how MNP assemblies can accurately quantify cellular and tissue mechanics, providing new opportunities for mechanobiological studies and enabling the development of novel readouts of cellular mechanics with potential diagnostic applications. Coprecipitation ; Iron oxide nanoparticles ; Nanoparticle ; Mechanobiology ; Magnetic nanoparticles ; Iron oxide Nanoparticle-Based Drug Delivery ; Characterization and Applications of Magnetic Nanoparticles ; Geomagnetism and Paleomagnetism Studies
Authors: Jeonghan Kang | Seung Yoon Nam | Sungho Lee
Source: Small Methods (article, 2026-03-01)
Field: Materials Science — Surfaces, Coatings and Films

Facile Fabrication of Superhydrophobic Surfaces with Hierarchical Structures via Water Vapor Condensation Surfaces with a water contact angle greater than 150° are defined as superhydrophobic surfaces, exhibiting characteristics such as water repellency, self-cleaning ability, and extremely low friction with water droplets. Most superhydrophobic surfaces possess micro- or nanoscale hierarchical structures; however, the fabrication of superhydrophobic surfaces typically requires considerable time and cost. Herein, we report a facile method for fabricating hierarchical structures via condensation of water vapor to address these problems. The size of the hierarchical structures can be controlled by adjusting the condensation time. The hierarchical structures via water vapor condensation exhibit the features of superhydrophobic surfaces, as confirmed by measurements of contact angle, sliding angle, and droplet impact behavior. As a feasible application, a self-cleaning test is also carried out. The facile fabrication method in this study is expected to be easily applicable for hierarchical structure formation and further extended to large-area sample production. Fabrication ; Contact angle ; Condensation ; Water vapor ; Nanoscopic scale ; Wetting Surface Modification and Superhydrophobicity ; Nanofabrication and Lithography Techniques ; Adhesion, Friction, and Surface Interactions
Authors: Arshad Rahman Parathodika | Kinsuk Naskar
Source: Frontiers in Soft Matter (article, 2026-01-13)
Field: Materials Science — Polymers and Plastics

Sulfidic crosslinks in EPM: a strategy for advanced flexible EPM composites Ethylene–propylene rubber (EPM) is a fully saturated elastomer, which prevents its crosslinking by conventional accelerated sulfur curing that requires unsaturation. In this study, a hybrid curing approach is introduced to generate sulfidic crosslinks in EPM. The method combines organic peroxide curing with sulfur-based vulcanization. Peroxide generates radicals on the EPM backbone and forms macro radicals, which can be captured by sulfur species, forming sulfur macroradicals that couple either with each other or with other EPM macro radicals to create alkyl-alkyl sulfidic crosslinks in EPM. Alongside these, the system also contains conventional alkyl–alkyl carbon crosslinks generated by peroxide. While carbon–carbon crosslinks impart excellent thermal stability and compression set resistance in EPM, they often limit flexibility and tear strength. The incorporation of sulfidic crosslinks alongside peroxide-derived linkages enhances flexibility and stress strain performance without sacrificing high temperature capability. This hybrid curing route thus provides a promising strategy for developing advanced flexible EPM composites for applications demanding contradictory property requirements and higher thermal ratings than EPDM. Curing (chemistry) ; Sulfur ; Natural rubber ; Compression set ; Peroxide ; Vulcanization ; Composite number ; Thermal stability Polymer Nanocomposites and Properties ; Polymer composites and self-healing ; Epoxy Resin Curing Processes
Authors: Anuj Santosh Jagadale | Vivek Parshuram Diavte | Nilesh Dnyaneshwar Koli | Neha Agarwal
Source: International Journal of Technology & Emerging Research (article, 2026-01-30)
Field: Chemistry — Analytical Chemistry

Crude Beginning: The evolution of the pre-refining process Crude oil refining has evolved into one of the most sophisticated industrial processes, yet its efficiency is deeply influenced by the quality of crude before it even reaches the refinery. This paper explores the transformation of pre-refining operations—from early manual handling and natural settling methods to advanced separation, stabilization, and conditioning technologies deployed at the wellhead and storage terminals. Key processes such as dehydration, desalting, sediment removal, vapor pressure stabilization, and crude blending are examined to highlight their role in reducing corrosion, protecting catalysts, preventing equipment fouling, and improving final fuel quality. The paper also traces historical milestones that shaped modern feedstock preparation and discusses emerging trends in digital monitoring and intelligent crude logistics. The study reinforces that upstream crude conditioning is a fundamental enabler of refinery performance, economic optimization, and environmental compliance. Wellhead ; Refining (metallurgy) ; Crude oil ; Process (computing) ; Oil refinery ; Raw material ; Downstream (manufacturing) ; Expediting Petroleum Processing and Analysis ; Enhanced Oil Recovery Techniques ; Process Optimization and Integration
Authors: Xinyu Gao | Ziyu Wang | Yanping Luo | Luchao Sun | Jingyang Wang
Source: Journal of the American Ceramic Society (article, 2026-01-30)
Field: Materials Science — Ceramics and Composites

Multicomponent (Gd <sub>x1</sub> Ho <sub>x2</sub> Yb <sub>x3</sub> Lu <sub>x4</sub> ) <sub>2</sub> Si <sub>2</sub> O <sub>7</sub> Disilicates: Compositional Modulation and CMAS Corrosion Resistance at 1300°C ABSTRACT Multi‐rare‐earth‐principle‐component disilicates ((nRE x ) 2 Si 2 O 7 ) are advanced candidates for the environmental barrier coatings (EBCs) materials, wherein the multicomponent design strategy is used to achieve synergistic optimization on various material properties. In this study, two (nRE x ) 2 Si 2 O 7 materials, that is, β‐(Gd 0.15 Ho 0.15 Yb 0.35 Lu 0.35 ) 2 Si 2 O 7 and γ‐(Gd 0.15 Ho 0.35 Yb 0.35 Lu 0.15 ) 2 Si 2 O 7 with distinct polymorphic structures are designed by exquisitely tuning the relative ratio of the four constituent rare‐earth elements. The two samples exhibit good stability of β or γ phase, low thermal conductivity, and coefficients of thermal expansion in good compatibility with the silicon carbide fiber‐reinforced silicon carbide ceramic matrix composites. The corrosion depth of β‐(Gd 0.15 Ho 0.15 Yb 0.35 Lu 0.35 ) 2 Si 2 O 7 and γ‐(Gd 0.15 Ho 0.35 Yb 0.35 Lu 0.15 ) 2 Si 2 O 7 samples after the completeness of CMAS corrosion process at 1300°C are approximately 428.33 and 239.70 µm, respectively. Such different corrosion behaviors have been attributed to the increased concentration of active elements (e.g., Ho), which serves multiple functions by accelerating apatite formation, consuming molten CMAS, decreasing the Ca/Si ratio, and significantly mitigating the activity of corrosion reactions. These results are expected to enlighten the synergistic optimization of thermo‐physical properties and corrosion resistance of (nRE x ) 2 Si 2 O 7 materials by compositional modulation, and provide important guidelines for the design and screening of advanced EBC materials. Corrosion ; Silicon carbide ; Thermal stability ; Ceramic ; Apatite ; Silicon ; Carbide Advanced ceramic materials synthesis ; High-Temperature Coating Behaviors ; Microwave Dielectric Ceramics Synthesis
Authors: Koushik Rameshbabu | Jing Luo | Ali Shargh | Khalid El-Awady | Jaafar El-Awady
Source: arXiv (Cornell University) (article, 2026-04-08)
Field: Materials Science — Materials Chemistry

From Papers to Property Tables: A Priority-Based LLM Workflow for Materials Data Extraction Scientific data are widely dispersed across research articles and are often reported inconsistently across text, tables, and figures, making manual data extraction and aggregation slow and error-prone. We present a prompt-driven, hierarchical workflow that uses a large language model (LLM) to automatically extract and reconstruct structured, shot-level shock-physics experimental records by integrating information distributed across text, tables, figures, and physics-based derivations from full-text published research articles, using alloy spall strength as a representative case study. The pipeline targeted 37 experimentally relevant fields per shot and applied a three-level priority strategy: (T1) direct extraction from text/tables, (T2) physics-based derivation using verified governing relations, and (T3) digitization from figures when necessary. Extracted values were normalized to canonical units, tagged by priority for traceability, and validated with physics-based consistency and plausibility checks. Evaluated on a benchmark of 30 published research articles comprising 11,967 evaluated data points, the workflow achieved high overall accuracy, with priority-wise accuracies of 94.93% (T1), 92.04% (T2), and 83.49% (T3), and an overall weighted accuracy of 94.69%. Cross-model testing further indicated strong agreement for text/table and equation-derived fields, with lower agreement for figure-based extraction. Implementation through an API interface demonstrated the scalability of the approach, achieving consistent extraction performance and, in a subset of test cases, matching or exceeding chat-based accuracy. This workflow demonstrates a practical approach for converting unstructured technical literature into traceable, analysis-ready datasets without task-specific fine-tuning, enabling scalable database construction in materials science. Workflow ; Scalability ; Consistency (knowledge bases) ; Benchmark (surveying) ; Pipeline (software) ; Data extraction ; Matching (statistics) ; Information extraction ; Property (philosophy) Machine Learning in Materials Science ; Data Quality and Management ; Biomedical Text Mining and Ontologies
Authors: Sameena Begum | Niranjan Panda | CH. PRAVEENA
Source: Asian Journal of Pharmaceutical and Clinical Research (article, 2026-01-07)
Field: Materials Science — Biomaterials

DESIGN AND DEVELOPMENT OF ENZALUTAMIDE-ENCAPSULATED POLYCAPROLACTONE NANOPARTICLES FOR PROSTATE CANCER: A BOX–BEHNKEN STATISTICAL APPROACH Objectives: This study presents the design and development of Enzalutamide (EZ)-encapsulated polycaprolactone (PCL) nanoparticles (NPs) for targeted prostate cancer therapy, employing a statistical Box–Behnken design to optimize formulation parameters. Methods: NPs were prepared through the emulsion solvent evaporation method and evaluated for particle size, entrapment efficiency (EE) %, and zeta potential. In vivo pharmacokinetic and cytotoxicity studies were carried out to ensure the in vivo efficacy of the optimised formulation. Results: The formulations exhibited particle sizes ranging from 148 nm to 219 nm, EE% between 70% and 92%, and zeta potentials from −13.4 mV to −32.5 mV, indicating good colloidal stability. Transmission electron microscopy confirmed spherical morphology, while Fourier-transform infrared spectroscopy (FTIR) revealed no significant chemical interactions between EZ and PCL, confirming compatibility. Cytotoxicity studies demonstrated enhanced anticancer activity of the optimized NPs, with a lower half-maximal inhibitory concentration (14.27 μg/mL) value compared to pure EZ (22.24 μg/mL), suggesting improved cellular uptake and therapeutic efficacy. In the pharmacokinetic evaluation, EZ-loaded optimized NPs (Opt-EZ-PCL-NPs) exhibited a threefold enhancement in area under the curve (34.42 μg.h/mL) (p&lt;0.05) relative to the pure EZ suspension formulation (11.30 μg.h/mL) (p&lt;0.05), reflecting improved systemic bioavailability. Conclusion: These findings support the potential of PCL-based nanocarriers as an effective delivery system for EZ in PC treatment. Zeta potential ; Polycaprolactone ; Nanocarriers ; Cytotoxicity ; In vivo ; Nanoparticle ; Particle size ; Pharmacokinetics ; Particle (ecology) Nanoparticle-Based Drug Delivery ; Advanced Drug Delivery Systems ; Nanoplatforms for cancer theranostics