jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Yuting Niu | Bo Peng
Source: Journal of Physics Conference Series (article, 2025-11-01)
Field: Materials Science — Materials Chemistry

Growth of Large-area CrI <sub>3</sub> Films by CVD with Lewis Base Passivation Abstract The two-dimensional van der Waals material CrI 3 has attracted significant attention owing to its fundamental properties and application potential. However, its rapid ambient degradation remains a critical obstacle to its scalable fabrication and application. Here, we report a chemical vapor deposition (CVD) approach for synthesizing large-area CrI 3 thin films, with a synergistic stabilization strategy combining Lewis base passivation and Parylene C encapsulation. We demonstrate that while Parylene C effectively retards degradation from ambient moisture and oxygen, it alone cannot entirely prevent degradation originating from intrinsic defects. To address this issue, we introduce Lewis base passivation to passivate intrinsic defects, including unsaturated chromium ions and iodine vacancies, significantly enhancing environmental stability. Among the assessed Lewis bases, 2,2’-(ethylenedioxy)diethylamine (EDEA) exhibits optimal passivation capability due to the flexible chain and electron modulation between its amino and oxygen groups. The retention of structural and chemical properties upon passivation, as confirmed by Raman spectroscopy, suggests the promise of this approach. This work provides a robust and scalable route to produce air-stable, large-area CrI3 films, a critical step towards their fundamental study and potential application. Furthermore, the proposed strategy is expected to be applicable for stabilizing other air-sensitive 2D transition metal halides via CVD. Passivation ; Lewis acids and bases ; Degradation (telecommunications) ; Fabrication ; Raman spectroscopy ; Chemical vapor deposition ; Parylene 2D Materials and Applications ; Perovskite Materials and Applications ; Advanced Photocatalysis Techniques
Authors: Sejal Dhotre | Shrikrishna Baokar | Rajendra Patil
Source: International Journal of Pharmaceutical Sciences Review and Research (article, 2025-07-01)
Field: Materials Science — Biomaterials

Liposomal Medicine Drug Delivery Systems from Concept to Clinical Operation Liposomal medicine delivery systems represent a groundbreaking advancement in pharmaceutical lores, offering an effective platform for the targeted delivery of remedial agents.By recapitulating medicines within lipid bilayers, liposomes enhance medicine solubility, reduce systemic toxin, and protract rotation time.This review provides a comprehensive overview of liposome technology, from its abstract origins to current clinical operations.It discusses the bracket, medication styles, medicine lading strategies, and characterization ways, alongside real-world exemplifications of FDA-approved liposomal medicines.Likewise, the review explores current challenges, implicit results, and unborn perspectives in optimizing liposome-grounded delivery for perfection drug.Liposomal medicine delivery systems have come a foundation in the development of advanced pharmaceutical phrasings, particularly for clinical use.By recapitulating remedial agents within biocompatible lipid bilayers, liposomes offer bettered medicine solubility, enhanced bioavailability, and the capability to target specific apkins or cells.These features contribute to reduced systemic toxin and bettered remedial issues.Clinically, liposomal phrasings have been approved for the treatment of colourful conditions, including cancer, fungal infections, and viral conditions.Notable exemplifications include liposomal doxorubicin for cancer remedy and liposomal amphotericin B for systemic fungal infections.Inventions similar as PEGylation and ligand targeting have further meliorated liposomal systems, enhancing rotation time and particularity.As exploration continues to evolve, liposomes are anticipated to play an increasingly important part in delivering complex rectifiers, including inheritable accoutrements and immunotherapies, across a wide range of clinical settings. Drug delivery ; Liposome ; Delivery system ; Medicine ; Drug ; Computer science ; Intensive care medicine ; Medical physics ; Biomedical engineering ; Pharmacology ; Nanotechnology ; Materials science Nanoparticle-Based Drug Delivery ; Monoclonal and Polyclonal Antibodies Research ; Advanced Drug Delivery Systems
Authors: Innocent Chukwujekwu Onunkwo | M. O. Edema | Christiana Ene Ogwuche
Source: Research Square (preprint, 2025-11-17)
Field: Materials Science — Polymers and Plastics

Cissus aralioides Leaf: Cosmetological Application of the Methanol extract, Its Silver and Zinc Oxide Nanoparticles and Characterization Methanol ; Zinc ; Saponification ; Nanoparticle ; Scanning electron microscope ; Antimicrobial ; Fourier transform infrared spectroscopy Polymer Science and PVC ; Essential Oils and Antimicrobial Activity ; Advancements in Transdermal Drug Delivery
Authors: Sangkil Nam | Joungmo Cho | Simon MoonGeun Jung | Hyun‐Jun Lee | Hyung Won Ryu | Sei‐Ryang Oh | Kee‐In Lee
Source: International Journal of Molecular Sciences (article, 2025-02-10)
Field: Chemistry — Organic Chemistry

Practical Preparation of (3S)-Hydroxy-5-Phenylpentanoic Acid: Asymmetric Synthesis of (S)-Daphneolone and (S)-Dihydroyashabushiketol, and Formal Synthesis of (3S,5S)-Yashabushidiol B Many linear diarylpentanoids and diarylheptanoids contain a β-hydroxy ketone or 1,3-diol functionality as the structural motif. Reported herein is the asymmetric synthesis of (<i>S</i>)-daphneolone, (<i>S</i>)-dihydroyashabushiketol, and formal synthesis of (3<i>S</i>,5<i>S</i>)-yashabushidiol B as represented examples, employing readily accessible (3<i>S</i>)-hydroxy-5-phenylpentanoic acid. The (3<i>S</i>)-hydroxy-5-phenylpentanoic acid was conveniently prepared by the aldol addition of (<i>R</i>)-acetyloxazolidinone with 3-phenylpropanal affording two diastereomers which were cleanly separated by silica gel column chromatography, followed by the removal of Evans auxiliary of (3'<i>R</i>,4<i>S</i>)-imide. Then, the (<i>S</i>)-acid was converted to Weinreb amide as a privileged acylating agent. Three natural products with the uppermost optical purity were prepared by the treatment of organolithium or organomagnesium reagents, respectively, to the Weinreb amide used in common. We believe that this strategy provides a rapid and convergent method for constructing these classes of molecules of interest. Amide ; Aldol reaction ; Chemistry ; Diastereomer ; Reagent ; Total synthesis ; Ketone ; Silica gel ; Enantioselective synthesis ; Stereochemistry ; Combinatorial chemistry ; Organic chemistry ; Catalysis Carbohydrate Chemistry and Synthesis ; Synthetic Organic Chemistry Methods ; Asymmetric Synthesis and Catalysis
Authors: Larisa Păduraru
Source: Revista Medico-Chirurgicala (article, 2025-06-30)
Field: Materials Science — Biomaterials

RP-HPLC METHOD WITH UV DETECTION FOR THE EVALUATION OF CHITOSAN-GRAFT-Β-CYCLODEXTRIN/PVA HYDROGELS AS CARRIERS FOR THE CONTROLLED RELEASE OF VEMURAFENIB When developing a topical formulation, it is essential to evaluate it from the perspective of its carrier capacity for the controlled release of the encapsulated drug.The drug should be simply quantified through an accurate and reproducible method.This paper presents a rapid, simple, sensitive, and reproducible high-performance liquid chromatography method with UV detection for evaluating the ability of chitosan-graft--cyclodextrin/PVA (CS-g--CD/PVA) hydrogels as carriers for the controlled release of vemurafenib (VEM).Materials and methods: The chromatographic separation was achieved using a Waters CORTECS C18 column (100 2.1 mm ID, 2.7 m).The mobile phase was a mixture of: A (water/formic acid -99.9/0.1, v/v), B (acetonitrile), and C (methanol) in the ratio of 40: 55: 5 (v/v/v).The injection sample amount was 10 L, and the run time was 9 minutes in isocratic mode at a flow rate of 1 mL/min.The analyte was detected using UV absorption at 252 nm.Results: The standard calibration curve was linear over the concentration range of 0.78-100 mg/L.The values for LOD and LOQ were 0.5 mg/L and 0.75 mg/L, respectively.The intra-and inter-day precision of measurements were lower than the accepted criteria (RSD 2%).The high value of recoveries obtained for VEM indicates that the proposed method was found to be accurate.The stability of VEM solutions was assessed, indicating that the drug remained stable under all relevant conditions.Conclusions: Finally, the validated method was successfully applied to evaluate the ability of chitosan-graft--cyclodextrin/PVA hydrogels to load and sustain release of VEM.The drug entrapment efficiency (DEE%) was between 650.08% and 700.05%. Vemurafenib ; Controlled release ; Self-healing hydrogels ; Melanoma Nanoparticle-Based Drug Delivery ; HER2/EGFR in Cancer Research ; Monoclonal and Polyclonal Antibodies Research
Authors: Ling‐Jian Gui | Yingying Liu | Lisha Song | Lingyun Wan | Cuihong Yang | Wenjing Liang | Zhigang Yan | Shugen Wei | Jing Wang | Ming Lei
Source: Preprints.org (preprint, 2025-07-11)
Field: Chemistry — Inorganic Chemistry

Isofraxidin Biosynthesis in &lt;em&gt;Chloranthus&lt;/em&gt;: Genomic Insights into Metabolic Evolution of an early Angiosperm Phytoalexin As an early-diverging angiosperm lineage, Chloranthaceae produces specialized coumarins with documented antimicrobial and anti-inflammatory activities, which contribute to its ecological success. Isofraxidin, the most representative dihydroxycoumarin in this clade, exhibits significant pharmaceutical potential. However, its biosynthetic basis remains uncharacterized. Here, we assembled a high-quality triploid genome of Chloranthus erectus (8.57 Gb, contig N50=8.76 Mb) to explore the evolution of defensive metabolism. Genomic analysis revealed an ancient WGD event and expanded gene families associated with pathogen resistance. Metabolomic analysis identified at least 49 coumarin compounds in Chloranthus plants, significantly exceeding previous records. Integrated omics revealed 267 candidate biosynthetic genes across 9 enzyme families governing isofraxidin biosynthesis. PAL-4CL established the phenylpropanoid backbone, amplified COSY genes correlated with umbelliferone accumulation, and CYP71/OMT catalyzed terminal modifications. This study deciphers the chemical defense evolution in early angiosperms and enables engineering of plant-derived antimicrobials. Phytoalexin ; Biosynthesis ; Chemistry ; Biology ; Biochemistry ; Enzyme ; Resveratrol Metal-Catalyzed Oxygenation Mechanisms ; Photosynthetic Processes and Mechanisms ; Porphyrin and Phthalocyanine Chemistry
Authors: Lijun Cao | Xinyan Dai | Yonggang Wu | Xinwu Ba
Source: Coatings (article, 2025-09-02)
Field: Chemistry — Organic Chemistry

Emerging Photo-Initiating Systems in Coatings from Molecular Engineering Perspectives Photoinitiators (PIs) are pivotal in enabling energy-efficient, spatiotemporally controlled photopolymerization for coatings. To address application-specific demands of coatings, diverse systems of Norrish-Type I (e.g., oxime esters, acylphosphine oxides) and Type II (e.g., onium salts, ketones) PIs have been engineered through systematic molecular design strategies. A comprehensive review necessitates highlighting recent achievements in designing PIs by various molecular engineering approaches. The π-conjugation extension, push–pull structures, and auxochrome incorporation boost strong and long-wavelength absorption; unimolecular PI systems with hydrogen-donor modifications improve reactivity and reduce oxygen inhibition; photobleaching via cleavable bonds and blocking conjugation enables colorless coating and deep-penetration curing; polymerizable macromolecular designs enhance migration resistance; organosilicon-functionalized structures optimize monomer compatibility. These strategies bridge molecular innovations with advanced applications in biomedical and deep-cured coatings. Nanotechnology ; Materials science ; Computer science ; Engineering ethics ; Engineering Photopolymerization techniques and applications ; Nanofabrication and Lithography Techniques ; Surface Modification and Superhydrophobicity
Authors: Larisa Păduraru | Catalina Natalia Cheaburu-Yılmaz | Alina Diana Panainte | Mihai Apostu | Mădălina Vieriu | Andreea Crețeanu | Alexandru Sava | Nela Bibire
Source: Preprints.org (preprint, 2025-05-05)
Field: Chemistry — Organic Chemistry

Evaluation of Chitosan-Graft-β-Cyclodextrin/PVA Hydrogels as Carriers for Vemurafenib by RP-HPLC Method with UV Detection When developing a topical formulation, it is essential to evaluate it from the perspective of its carrier capacity for the controlled release of the encapsulated drug. The drug should be simply quantified through an accurate and reproducible method. This paper presents a rapid, simple, sensitive, and reproducible high-performance liquid chromatography method with UV detection for evaluating the ability of chitosan-graft-β-cyclodextrin/PVA (CS-g-β-CD/PVA) hydrogels as carriers for the controlled release of vemurafenib (VEM). The chromatographic separation was achieved using a Waters CORTECS C18 column (100 × 2.1 mm ID, 2.7 µm). The mobile phase was a mixture of: A (water/formic acid - 99.9/0.1, v/v), B (acetonitrile), and C (methanol) in the ratio of 40:55:5 (v/v/v). The injection sample amount was 10 μL, and the run time was 9 minutes in isocratic mode at a flow rate of 1 mL/min. The analyte was detected using UV absorption at 252 nm. The standard calibration curve was linear over the concentration range of 0.78-100 mg/L. The values for LOD and LOQ were 0.5 mg/L and 0.75 mg/L, respectively. The intra- and inter-day precision of measurements were lower than the accepted criteria (RSD ≤ 2%). The high value of recoveries obtained for VEM indicates that the proposed method was found to be accurate. The stability of VEM solutions was assessed, indicating that the drug remained stable under all relevant conditions. Finally, the validated method was successfully applied to evaluate the ability of chitosan-graft-β-cyclodextrin/PVA hydrogels to load and sustain release of VEM. The drug entrapment efficiency (DEE%) was between 65±0.08% and 70±0.05%. Cyclodextrin ; Chitosan ; Self-healing hydrogels ; Vemurafenib ; High-performance liquid chromatography ; Chemistry ; Chromatography ; Medicine ; Polymer chemistry ; Cancer research ; Biochemistry ; Melanoma Synthesis and biological activity ; Nanoparticle-Based Drug Delivery ; Synthesis of Tetrazole Derivatives
Authors: Pranay Sinha | Vinod L. Gaikwad | Debabrata Mandal | E. Bhargav | Rahul L. Gajbhiye | Ramalingam Peraman
Source: Research Square (preprint, 2025-11-05)
Field: Materials Science — Biomaterials

Integrated Stability and Metabolomic Investigation of New Rifampicin and Isoniazid co-loaded Liposome against Tuberculosis Liposome ; Isoniazid ; Mycobacterium tuberculosis ; Rifampicin ; Drug delivery ; Antimicrobial ; Drug ; Tuberculosis Nanoparticle-Based Drug Delivery ; Advancements in Transdermal Drug Delivery ; Inhalation and Respiratory Drug Delivery
Authors: Taís C. Silva | Julia Godoy-Silva | Monique C. Amaro | João Victor Silva‐Silva | Thiago Henrique Doring | Leonardo L. G. Ferreira | Adriano D. Andricopulo | Josué de Moraes
Source: Pharmaceuticals (article, 2025-07-02)
Field: Chemistry — Organic Chemistry

Phenotypic Screening of H1-Antihistamines Identifies Promethazine and Rupatadine as Active Compounds Against Toxocara canis Infective Larvae <b>Background</b>: Parasitic worm infections remain among the most prevalent and neglected health issues worldwide, affecting both humans and animals. Toxocariasis, caused by <i>Toxocara</i> spp., is a widespread zoonosis with significant public health and economic implications. Current anthelmintic treatments show limited efficacy, particularly against tissue-migrating larvae, underscoring the urgent need for new therapeutic options. This study aimed to evaluate the anthelmintic potential of H<sub>1</sub> antihistamines as repurposed drug candidates against <i>Toxocara canis</i>. <b>Methods</b>: Twenty-two H<sub>1</sub> antihistamines were screened for larvicidal activity against infective third-stage (L3) larvae of <i>T. canis</i>. Larval motility and morphology were assessed, and compounds with the highest efficacy were further investigated using density functional theory (DFT) to explore their electronic properties. Molecular docking simulations were also performed to predict interactions with <i>T. canis</i> β-tubulin. <b>Results</b>: Promethazine and rupatadine exhibited significant larvicidal effects, surpassing albendazole in reducing larval motility and inducing a distinct contorted morphology not observed in control or albendazole-treated larvae. DFT analyses suggested a strong electron-acceptor capacity, indicating a potential redox-based mechanism of action. Docking studies revealed favorable binding to the colchicine site of <i>T. canis</i> β-tubulin. <b>Conclusions</b>: This is the first report of larvicidal activity of antihistamines against <i>T. canis</i>, supporting their potential as repurposed therapeutic agents for the treatment of zoonotic helminthiases, particularly those caused by tissue-migrating nematodes. Toxocara canis ; Albendazole ; Toxocariasis ; Biology ; Anthelmintic ; Promethazine ; Pharmacology ; Canis ; Veterinary medicine ; Medicine ; Immunology ; Helminths ; Zoology ; Ecology Synthesis and Biological Evaluation ; Coccidia and coccidiosis research ; Insects and Parasite Interactions
Authors: Shuyu Wang | Wenchao Hao | Weili Shang | Ying Pan | Minghua Liu
Source: ChemistrySelect (article, 2025-07-01)
Field: Materials Science — Materials Chemistry

Co‐Assembly of Tetraphenylethylene‐Derived Glutamic Acid and Arginine via Chiral Recognition for Boosting Circularly Polarized Luminescence Abstract Chiral recognition is an important topic in supramolecular chemistry. Here, we present a chiral recognition‐driven supramolecular strategy that simultaneously controls nanoscale morphology and amplifies circularly polarized luminescence (CPL). A novel pair of enantiomeric glutamic acid derivatives functionalized with aggregation‐induced emission (AIE)‐active Tetraphenylethylene (TPE) was designed as chiral probes. While these compounds self‐assemble into CPL‐active irregular aggregates, their co‐assembly with arginine enantiomers exhibits remarkable chirality‐dependent behaviors. The homo‐chiral ( L ‐Arg/TPE‐ L ‐Glu) assemblies showed as a nanotube structured and dramatically enhanced CPL activity (|g lum | = 0.114), representing an 8‐fold increase over hetero‐chiral combinations (|g lum | = 0.014). The system enables simultaneous chiral discrimination through both CPL signal amplification and morphological differentiation. This work establishes a way in supramolecular chirality engineering, demonstrating chiral recognition can lead to the nanoscale architectures as well as enhanced chiroptical properties. Tetraphenylethylene ; Chirality (physics) ; Luminescence ; Supramolecular chemistry ; Supramolecular chirality ; Enantiomer ; Materials science ; Circular polarization ; Glutamic acid ; Chemistry ; Nanotechnology ; Combinatorial chemistry ; Stereochemistry ; Crystallography ; Amino acid ; Biochemistry ; Fluorescence ; Physics ; Aggregation-induced emission ; Optoelectronics ; Chiral symmetry breaking ; Optics ; Crystal structure Luminescence and Fluorescent Materials ; Synthesis and Properties of Aromatic Compounds ; Supramolecular Self-Assembly in Materials
Authors: Nihad Kadi
Source: Clinical & Experimental Dermatology and Therapies (review, 2025-08-25)
Field: Materials Science — Biomaterials

Handheld Electrospinning Technology for Wound Care: An Evaluation of Performance Against Current Therapies A Systematic Review By Nihad Kadi · 2025 · Read by 227 — Handheld Electrospinning Technology for Wound Care: An Evaluation of Performance Against Current Therapies A Systematic Review in Clinical & Experimental Dermatology and Therapies Mobile device ; Medicine ; Current (fluid) ; Systematic review ; Wound care ; Electrospinning ; Intensive care medicine ; Biomedical engineering ; Computer science ; MEDLINE ; Engineering ; Materials science ; Electrical engineering ; World Wide Web ; Composite material ; Political science Electrospun Nanofibers in Biomedical Applications
Authors: Lili Liu | Yanqiu Duan | Meiqi Chang
Source: Medical Materials Research (article, 2025-03-04)
Field: Materials Science — Materials Chemistry

Classification, Characteristics and Biological Applications of Inorganic Nanomaterials The application of inorganic nanomaterials in disease has attracted increasing attention, particularly in the areas of bioimaging, antibacteria and disease treatment. Due to their unique physicochemical properties, such as good biocompatibility, adjustable surface characteristics and excellent stability, inorganic materials have become an important component in drug delivery systems and nanomedicine. Common inorganic materials serve not only to effectively deliver drugs and facilitate controlled release within the body, but also to enhance their biological effects through specific functionalization strategies. This review aims to provide a comprehensive analysis of the latest advancements in the field of inorganic nanomaterials. The categorization and properties of inorganic nanomaterials are presented to elucidate potential structure-function relationships. Additionally, the engineering of inorganic nanomaterials for biomedical applications is comprehensively summarized. Finally, the current challenges and future directions are discussed and projected to foster technological advancements in the efficient treatment of diseases. Nanomaterials ; Drug delivery ; Surface modification ; Inorganic Chemical ; Biological materials Advanced Nanomaterials in Catalysis