jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Fereshteh Jafarzadeh | Hossein Peyman | Hamideh Roshanfekr | Shohreh Azizi | Azeez Olayiwola Idris | M. Mâaza
Source: Arabian Journal for Science and Engineering (article, 2024-02-10)
Field: Materials Science — Biomaterials

Fabrication of a Nanomagnetic Smart Polymer Carrier as a Potential Candidate for a Drug Delivery System Abstract We developed an intelligent device capable of controlled release of anti-cancer drugs. The nano-carrier consists of two key components: firstly, magnetic nanoparticles were synthesized through co-precipitation and then functionalized for attaching anti-cancer drugs; secondly, a polymer (poly( N -isopropylacrylamide- co -acrylic acid)) sensitive to pH and temperature was synthesized and employed to encapsulate the drug-loaded magnetic nanoparticles. This responsive polymer exhibits a lower critical solution temperature (LCST) of 38.5 °C, indicating a phase transition behavior. Numerous techniques and analyses, including Fourier transform infrared spectroscopy, thermogravimetric analysis, zeta potentials, scanning electron microscope, and transmission electron microscopy, were employed to confirm the successful execution of the aforementioned process. In vitro release assessments of the anti-cancer drug, doxorubicin, were conducted across various media (pH 5–8 and temperatures ranging from 20 to 40 °C). The outcomes revealed higher drug releases at temperatures exceeding the LCST (40 °C) and at slightly acidic pH levels (5–5.3). Notably, compared to the effectiveness of the unloaded drug, the magnetic smart polymer loaded with DOX exhibited a more potent cytotoxic effect. Considering these results, this nano-carrier emerges as a promising candidate for targeted therapeutic delivery to cancerous tissues. Lower critical solution temperature ; Polymer ; Materials science ; Thermogravimetric analysis ; Smart polymer ; Drug delivery ; Nanotechnology ; Zeta potential ; Chemical engineering ; Nanoparticle ; Fourier transform infrared spectroscopy ; Transmission electron microscopy ; Nuclear chemistry ; Scanning electron microscope ; Chemistry ; Copolymer ; Composite material Nanoparticle-Based Drug Delivery ; Hydrogels: synthesis, properties, applications ; Graphene and Nanomaterials Applications
Authors: Bin Hu | Haizeng Song | Xinlei Zhang | Yuan He | Jicun Ren | Jingbin Huang
Source: Polymers (article, 2024-12-19)
Field: Materials Science — Polymers and Plastics

Effects of Phenoxazine Chromophore on Optical, Electrochemical and Electrochromic Behaviors of Carbazole–Thiophene Derivatives Phenoxazine, as an organic-small-molecule chromophore, has attracted much attention for its potential electrochromic applications recently. To develop appealing materials, phenoxazine chromophores were introduced at the N-position of carbazole-thiophene pigment, yielding two novel monomers (DTCP and DDCP), whose chemical structures were characterized by NMR, HRMS and FTIR. The results of the optical property study indicate that little influence could be observed in the presence of the phenoxazine chromophore. Corresponding polymer films on the surface of an ITO/glass electrode were obtained through electropolymerization. The electrochemical features displayed were various due to the introduction of the phenoxazine group. The spectroelectrochemical results demonstrate that the color of the polymer films could be changed. Compared with the PDDC films, the PDDCP films exhibited three different colors (tangerine, green and purple colors) in different redox states, which could be attributed to the synergistic effect between the carbazole-thiophene conjugate chain and the phenoxazine group. Moreover, fast switching time could be seen due to the presence of the phenoxazine chromophore. This study could provide a reference for obtaining high-performance electrochromic materials. Phenoxazine ; Chromophore ; Electrochromism ; Carbazole ; Photochemistry ; Thiophene ; Materials science ; Electrochromic devices ; Polymer ; Electrochemistry ; Monomer ; Chemistry ; Polymer chemistry ; Combinatorial chemistry ; Organic chemistry ; Phenothiazine ; Electrode ; Physical chemistry Conducting polymers and applications ; Transition Metal Oxide Nanomaterials ; Photochromic and Fluorescence Chemistry
Authors: Yuxin Liu | Wei Zheng
Source: The Chemical Record (review, 2024-09-05)
Field: Materials Science — Materials Chemistry

Multichannel Lanthanide‐Doped Nanoprobes for Serodiagnosis and Therapy In this account, we will highlight recent progress in the development of multichannel lanthanide-doped (MC-Ln) nanoprobes for highly efficient serodiagnosis and therapy, with a particular focus on our own work. First, we first provide a classification of the types of MC-Ln nanoprobes based on the contained type and number of signals. The merits of different types of nanoprobes and the reason using lanthanides are elucidated. Then, we provide an overview of the current uses of MC-Ln nanoprobes in serodiagnosis and therapy, focusing on the strategic exploration to improve the diagnostic and therapeutic performance from different perspectives. Finally, we present a prospective outlook on the future development and potential issues of next-generation MC-Ln nanoprobes. We hope that this timely account will update our understanding of MC-Ln and similar nanoprobes for bioapplications and provide helpful references for the state-of-the-art tools for serodiagnosis and therapy. Nanotechnology ; Lanthanide ; Materials science ; Computer science ; Chemistry Nanocluster Synthesis and Applications ; Advanced biosensing and bioanalysis techniques ; Quantum Dots Synthesis And Properties
Authors: Niveditha N. Mallik | Chandramouli Manasa | Vrushabendra Basavanna | Dileep C. Shanthakumar | Srikantamurthy Ningaiah | N.S. Lingegowda
Source:  (review, 2024-01-30)
Field: Chemistry — Organic Chemistry

Synthesis of Fused Isoxazoles: A Comprehensive Review Pharmaceutically important isoxazoles are within the wide range of heterocycles. The isoxazole ring, being five-membered, is also found in many bioactive natural products in addition to synthetic drugs. Many significant properties are exhibited by synthetically modified isoxazoles. Fused isoxazoles have widely shown their therapeutic potential as anticancer, insecticidal, antibacterial, antituberculosis, antifungal, antibiotic, antitumor, and antiulcerogenic agents. A variety of strategies are employed for the synthesis of these compounds, which are known for their pharmacological importance. Their synthesis is here reviewed. Synthesized isoxazoles have appeared as good forerunners for many other different molecules. This review summarizes the various synthesis approaches described so far for isoxazoles, providing a detailed study of their synthesis process. Substituted isoxazoles have been well discussed in the literature for their significant biological activities. This review is mainly focused on the synthesis of fused isoxazoles. Isoxazole ; Antifungal ; Combinatorial chemistry ; Chemistry ; Nanotechnology ; Organic chemistry ; Biology ; Materials science ; Microbiology Synthesis and biological activity ; Synthesis of heterocyclic compounds ; Multicomponent Synthesis of Heterocycles
Authors: Patryk Obstarczyk | Julia Osmólska | Michał Swierczewski | Thomas Bürgi | Marek Samoć | Joanna Olesiak‐Bańska
Source: Journal of Materials Chemistry C (article, 2024-01-01)
Field: Materials Science — Materials Chemistry

Enhanced nonlinear optical properties of Au <sub>25</sub> nanocluster oligomers linked by bidentate dithiol Oligomerization of atomically-precise clusters leads to enhancements of their nonlinear optical performance (9000 GM for monomers, 66 000 GM for trimers). Dithiol ; Materials science ; Nonlinear optical ; Denticity ; Nanoclusters ; Chemistry ; Nanotechnology ; Nonlinear system ; Crystallography ; Physics ; Crystal structure ; Quantum mechanics Nanocluster Synthesis and Applications ; Laser-Ablation Synthesis of Nanoparticles ; Nonlinear Optical Materials Studies
Authors: Chaoyi Jin | Xuelan Mei | Yan Zhou | Licun Li | Jean‐Pascal Sutter
Source: Inorganic Chemistry (article, 2024-12-03)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Single-Molecule Magnet Behavior in a Tb-Nitronyl Nitroxide Radical Network with [Tb<sub>3</sub>(NIT)<sub>2</sub>] Nodes Two rare two-dimensional Ln-radical networks, namely, [{Ln(tfa)<sub>3</sub>}<sub>3</sub>(NIT-4Py)<sub>2</sub>]<sub><i>n</i></sub> [Ln<sup>III</sup> = Gd <b>1</b> and Tb <b>2</b>; tfa<sup>-</sup> = trifluoroacetylacetonato; and NIT-4Py = 2-(4-pyridyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide], have been successfully constructed and characterized. In these complexes, each NIT-4Py radical functions as a tridentate ligand to ligate three Ln ions, creating a 2D network with linear five-spin [Ln<sub>3</sub>(NIT)<sub>2</sub>] nodes. Ferromagnetic Ln-NO interactions govern the characteristic magnetic behavior of a finite spin system. The Tb complex is shown to exhibit SMM behavior in a zero DC field, with an energy barrier for spin flipping of 53 K and hysteretic M-H behavior at 2.3 K, with a coercive field <i>H</i><sub>coer</sub> = 110 Oe. This complex represents the first example of a Ln-nitronyl nitroxide SMM-based network. Nitroxide mediated radical polymerization ; Chemistry ; Nat ; Ferromagnetism ; Crystallography ; Magnet ; Spin (aerodynamics) ; Molecule ; Ion ; Field (mathematics) ; Single-molecule magnet ; Condensed matter physics ; Magnetic field ; Stereochemistry ; Physics ; Magnetization ; Quantum mechanics ; Polymer ; Polymerization ; Thermodynamics ; Pure mathematics ; Radical polymerization Magnetism in coordination complexes ; Lanthanide and Transition Metal Complexes ; Organic and Molecular Conductors Research
Authors: Minseouk Choi | Young Shik Cho | Kyung Tae Park | Kyunbae Lee | Keun‐Young Shin | Yeonsu Jung | Taehoon Kim
Source: Functional Composites and Structures (article, 2024-04-15)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Unique correlation between electrical, structural properties and electromagnetic shielding properties of carbon nanotube sheets Abstract Correlation between electrical, structural properties and electromagnetic shielding efficiency (EMI SE) of carbon nanotube sheets (CNTSs) was investigated. Solvent densification of CNTSs led to enhancements of carbon nanotube (CNT) bundling behavior and densification in the thickness direction while maintaining the areal density of the CNTSs. These structural modifications resulted in enhanced electrical properties and reduced sheet thickness by modifying the microstructure and bundling characteristics. Remarkably, contrary to conventional EMI shielding materials, the sheet resistance which reflects bundling behavior and microstructure of CNTSs, is the critical factor affecting the EMI SE of the CNTSs rather than electrical conductivity. The findings provide fundamental insights essential for the design of EMI shielding films incorporating CNTs. Electromagnetic shielding ; Materials science ; Microstructure ; Carbon nanotube ; EMI ; Composite material ; Electrical resistivity and conductivity ; Nanotube ; Electromagnetic interference ; Shielding effect ; Electrical resistance and conductance ; Electrical conductor ; Nanotechnology ; Electronic engineering ; Electrical engineering Electromagnetic wave absorption materials ; Advanced Energy Technologies and Civil Engineering Innovations ; Cellular and Composite Structures
Authors: Hailiang Liao | Achilleas Savva | Adam V. Marsh | Yu‐Ying Yang | Hendrik Faber | Martina Rimmele | Matteo Sanviti | Renqian Zhou | Abdul‐Hamid Emwas | Jaime Martín | Thomas D. Anthopoulos | Martin Heeney
Source: Angewandte Chemie International Edition (article, 2024-09-18)
Field: Materials Science — Polymers and Plastics

High Performance Organic Mixed Ionic‐Electronic Polymeric Conductor with Stability to Autoclave Sterilization We present a series of newly developed donor-acceptor (D-A) polymers designed specifically for organic electrochemical transistors (OECTs) synthesized by a straightforward route. All polymers exhibited accumulation mode behavior in OECT devices, and tuning of the donor comonomer resulted in a three-order-of-magnitude increase in transconductance. The best polymer gFBT-g2T, exhibited normalized peak transconductance (g<sub>m,norm</sub>) of 298±10.4 S cm<sup>-1</sup> with a corresponding product of charge-carrier mobility and volumetric capacitance, μC*, of 847 F V<sup>-1</sup> cm<sup>-1</sup> s<sup>-1</sup> and a μ of 5.76 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup>, amongst the highest reported to date. Furthermore, gFBT-g2T exhibited exceptional temperature stability, maintaining the outstanding electrochemical performance even after undergoing a standard (autoclave) high pressure steam sterilization procedure. Steam treatment was also found to promote film porosity, with the formation of circular 200-400 nm voids. These results demonstrate the potential of gFBT-g2T in p-type accumulation mode OECTs, and pave the way for the use in implantable bioelectronics for medical applications. Materials science ; Polymer ; Autoclave ; Transconductance ; Electrochemistry ; Capacitance ; Acceptor ; Nanotechnology ; Electrode ; Composite material ; Electrical engineering ; Transistor ; Chemistry ; Voltage Conducting polymers and applications ; Advanced Sensor and Energy Harvesting Materials ; Organic Electronics and Photovoltaics
Authors: Jun Mok Ha | Seoung Ho Lee | D. Park | Young Jun Yoon | In Mok Yang | Junhyeok Seo | Yong Seok Hwang | Chan Young Lee | Jae Kwon Suk | Jun Kue Park | Sunmog Yeo
Source: Discover Nano (article, 2024-05-07)
Field: Materials Science — Materials Chemistry

Synthesis mechanism from graphene quantum dots to carbon nanotubes by ion-sputtering assisted chemical vapor deposition We present the first work of the synthesis mechanism from graphene quantum dots (GQDs) to carbon nanotubes (CNTs) by an ion-sputtering assisted chemical vapor deposition. During the annealing process, a Pt thin film deposited by the ion-sputtering was dewetted and agglomerated to form many nanometer-sized particles, leading to Pt nanoparticles (PtNPs) that can act as catalysts for creating carbon allotropes. The shape of the allotropes can be effectively tailored from GQDs to CNTs by controlling three key parameters such as the dose of catalytic ions (D), amounts of carbon source (S), and thermal energy (T). In our work, it was clearly proved that the growth control from GQDs to CNTs has a comparably proportional relationship with D and S, but has a reverse proportional relationship with T. Furthermore, high-purity GQDs without any other by-products and the CNTs with the cap of PtNPs were generated. Their shapes were appropriately controlled, respectively, based on the established synthesis mechanism. Graphene ; Carbon nanotube ; Materials science ; Sputtering ; Chemical vapor deposition ; Nanotechnology ; Chemical engineering ; Quantum dot ; Nanoparticle ; Carbon fibers ; Ion ; Thin film ; Composite material ; Chemistry ; Organic chemistry ; Composite number Carbon and Quantum Dots Applications ; Graphene research and applications ; Graphene and Nanomaterials Applications
Authors: Minyu Chen | Sylvie Marguet | Ali Issa | Safi Jradi | Christophe Couteau | Céline Fiorini‐Debuisschert | Ludovic Douillard | Olivier Soppera | Dandan Ge | Jérôme Plain | Xuan Zhou | Cuong Dang | Jérémie Béal | Sergeï Kostcheev | Régis Déturche | Tao Xu | Bin Wei | Renaud Bachelot
Source: ACS Photonics (review, 2024-08-22)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Approaches for Positioning the Active Medium in Hybrid Nanoplasmonics. Focus on Plasmon-Assisted Photopolymerization Over the past 20 years, hybrid plasmonics for nanoemitters of light or for nanoabsorbers, based on weak or strong coupling between metallic nanocavities and active media (emissive or absorbing entities), have given rise to important research efforts. One of the main current challenges is the control of the nanoscale spatial distribution and associated symmetry of the active medium in the vicinity of the metallic nanoparticles. In this review, we first recall the main principles of weak and strong coupling by stressing the importance of controlling the spatial distribution of the active medium and present the main approaches developed for achieving this control. Nine different approaches are identified. We then focus our attention on one of them based on plasmonic photopolymerization and discuss the flexibility of this approach in terms of control of the spatial symmetry of the hybrid nanosystem metal-polymer nanoemitters and the resulting polarization dependence of the light emission. The different approaches are analyzed and compared with each other, and some future perspectives and challenges are finally discussed. Plasmon ; Materials science ; Flexibility (engineering) ; Nanotechnology ; Polarization (electrochemistry) ; Nanoscopic scale ; Focus (optics) ; Optoelectronics ; Optics ; Physics ; Chemistry Gold and Silver Nanoparticles Synthesis and Applications ; Plasmonic and Surface Plasmon Research ; Photonic Crystals and Applications
Authors: Dominic Schatz | Marcel E. Baumert | Marie C. Kersten | Finn M. Schneider | Mogens Brøndsted Nielsen | Max M. Hansmann | Hermann A. Wegner
Source: Angewandte Chemie International Edition (article, 2024-06-13)
Field: Materials Science — Materials Chemistry

<i>para</i>‐Aminoazobenzenes—Bipolar Redox‐Active Molecules Azobenzenes (ABs) are versatile compounds featured in numerous applications for energy storage systems, such as solar thermal storages or phase change materials. Additionally, the reversible one-electron reduction of these diazenes to the nitrogen-based radical anion has been used in battery applications. Although the oxidation of ABs is normally irreversible, 4,4'-diamino substitution allows a reversible 2e<sup>-</sup> oxidation, which is attributed to the formation of a stable bis-quinoidal structure. Herein, we present a system that shows a bipolar redox behaviour. In this way, ABs can serve not only as anolytes, but also as catholytes. The resulting redox potentials can be tailored by suitable amine- and ring-substitution. For the first time, the solid-state structure of the oxidized form could be characterized by X-ray diffraction. Redox ; Chemistry ; Inorganic chemistry Photochromic and Fluorescence Chemistry ; Free Radicals and Antioxidants ; Photoreceptor and optogenetics research
Authors: Marta Gordo‐Lozano | Marcos Martínez‐Fernández | Rajendra Prasad Paitandi | José I. Martínez | José L. Segura | Shu Seki
Source: Small (article, 2024-11-20)
Field: Materials Science — Materials Chemistry

Boosting Photoconductivity by Increasing the Structural Complexity of Multivariate Covalent Organic Frameworks The assessment of the photoconductivity of Donor-Acceptor (D-A) ordered bulk heterojunctions is gaining attention for the development of innovative organic semiconductors in optoelectronics. Here, the synthesis of pyrene-based (D) Covalent Organic Frameworks, achieve through a multivariate reaction involving two distinct acceptors is reported (A). The products are characterized using powder x-ray diffraction, N<sub>2</sub> sorption isotherms, electronic microscopy, and in silico calculations, among other techniques. These characterizations reveal that the multicomponent synthesis enables the modification of properties (e.g., bandgap) of the framework while preserving its structural features, such as crystallinity and porosity. The ordered D-A arrays position these materials as promising candidates for photoconductive semiconductors, particularly regarding the variation in the composition of isotopological frameworks. Photoconductivity experiments demonstrate a volcano-type correlation with respect to the A moiety content, with the optimal value reaching 7.9 × 10<sup>-5</sup> cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> for the bare NIP<sub>25%</sub>-COF. This study illustrates how introducing diverse acceptor units through multivariate synthesis can enhance the photoconductivity of these materials via "defect" engineering, without sacrificing their crystalline or porous characteristics and avoiding the need for de novo synthesis. Photoconductivity ; Materials science ; Crystallinity ; Covalent bond ; Band gap ; Acceptor ; Covalent organic framework ; Porosity ; Optoelectronics ; Organic chemistry ; Chemistry ; Composite material Covalent Organic Framework Applications ; Metal-Organic Frameworks: Synthesis and Applications ; Advanced Photocatalysis Techniques
Authors: Sébastien Meyer | Alexandre Neuhut | Aurélie Claraz
Source: Organic & Biomolecular Chemistry (article, 2024-01-01)
Field: Chemistry — Organic Chemistry

Electrochemical sulfonylation/Truce–Smiles rearrangement of <i>N</i>-allylbenzamides: toward sulfone-containing β-arylethylamines and Saclofen analogues The β-arylethylamine pharmacophore is commonly found in medications for central nervous system disorders, prompting the need for safe and efficient methods to endow this motif with relevant functional groups for drug discovery. In this context, herein, we have established electrochemical radical sulfonylation reactions of <i>N</i>-allylbenzamides followed by Truce-Smiles rearrangement to produce sulfone- and sulfonate ester-containing β-arylethylamines. Electricity enables this transformation to occur under mild and oxidant-free conditions. Simple sources of sulfonyl radicals and SO<sub>2</sub> surrogates were employed to form sulfones and sulfonate esters, respectively. This practical and operationally robust method exhibited a broad substrate scope with good to high yields. The prospective pharmaceutical utility of the process was further demonstrated by removing the <i>N</i>-protecting groups and hydrolysing the sulfonate ester moiety to provide γ-sulfonyl-β-arylamines and Saclofen. Sulfone ; Smiles rearrangement ; Sulfonic acid ; Electrochemistry ; Chemistry ; Stereochemistry ; Organic chemistry ; Electrode ; Physical chemistry Sulfur-Based Synthesis Techniques ; Phenothiazines and Benzothiazines Synthesis and Activities ; Radical Photochemical Reactions
Authors: Luan F. Diniz | Paulo S. Carvalho | Mateus Araújo Castro e Souza | Renata Diniz | Christian Fernandes
Source: Molecular Pharmaceutics (article, 2024-06-10)
Field: Chemistry — Physical and Theoretical Chemistry

Highly Soluble Dacarbazine Multicomponent Crystals Less Prone to Photodegradation Dacarbazine (DTIC) is a widely prescribed oncolytic agent to treat advanced malignant melanomas. Nevertheless, the drug is known for exhibiting low and pH-dependent solubility, in addition to being photosensitive. These features imply the formation of the inactive photodegradation product 2-azahypoxanthine (2-AZA) during pharmaceutical manufacturing and even drug administration. We have focused on developing novel DTIC salt/cocrystal forms with enhanced solubility and dissolution behaviors to overcome or minimize this undesirable biopharmaceutical profile. By cocrystallization techniques, two salts, two cocrystals, and one salt-cocrystal have been successfully prepared through reactions with aliphatic carboxylic acids. A detailed structural study of these new multicomponent crystals was conducted using X-ray diffraction (SCXRD, PXRD), spectroscopic (FT-IR and <sup>1</sup>H NMR), and thermal (TG and DSC) analyses. Most DTIC crystal forms reported display substantial enhancements in solubility (up to 19-fold), with faster intrinsic dissolution rates (from 1.3 to 22-fold), contributing positively to reducing the photodegradation of DTIC in solution. These findings reinforce the potential of these new solid forms to enhance the limited DTIC biopharmaceutical profile. Cocrystal ; Solubility ; Photodegradation ; Dissolution ; Chemistry ; Combinatorial chemistry ; Salt (chemistry) ; Dacarbazine ; Nuclear chemistry ; Organic chemistry ; Photocatalysis ; Molecule ; Hydrogen bond ; Catalysis Crystallography and molecular interactions ; Crystallization and Solubility Studies ; Enzyme Structure and Function