jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Mingyang Wu | Jiandong Guo | Yunhui Meng | Lijia Zhang | Miao Feng | Yuchen Yang | Sun Ke | Shi-Tong Zhang | Xiaobai Li | Hongwei Ma
Source: Advanced Composites and Hybrid Materials (article, 2025-11-04)
Field: Materials Science — Materials Chemistry

Facile fabrication of light-activated multi-level output system based on thienyl-diphenylethene: Toward intelligent multimodal security protection Organic photochromic compounds represent a crucial class of smart-responsive materials, widely utilized in the fields comprising information storage and anti-counterfeiting. However, their practical applications are often hindered by intrinsic limitations, including lack of multifunctionality and poor stability. These shortcomings impede the realization of versatile performances, restrict compatibility with various anti-counterfeiting strategies, and consequently narrow their application prospects. Therefore, aiming at effectively keeping information security, it is imperative to develop novel materials capable of adapting to a broad range of encryption techniques. Herein this study, a thiophene-stilbene-based optical switching system was successfully developed in the solid state, based on three newly synthesized photochromic molecules: 3,3'-(2,2-diphenylethene-1,1-diyl)bis(benzo[b]thiophene) (2PBS), 3,3'-(2-phenylethene-1,1-diyl)bis(benzo[b]thiophene) (HPBS), and (Z)-1,2-bis(benzo[b]thiophen-3-yl)-1,2-diphenylethene (2PSF), whose reversible and high-contrast photochromic properties were found along with bright fluorescence emission. Upon exposure to ultraviolet (UV) light, the system suffered a rapid photochromic process from white to vivid red or violet, while quickly reverting to the original color under visible light, whereas this ideal material may effectively address practical application barriers required for time-dependent color changes and high sensitivity. In order to enhance its versatility, such a system is seamlessly integrated with various encryption mechanisms, e.g. temperature- and time-based strategies, based on the combination of an aryl vinyl backbone with photoactive thiophene moiety, in addition of integrating logic gates and computational base conversions, while embedding key decryption parameters into complex program logic to promote data protection. Surprisingly, this approach enables to simply achieve near-unlimited information storage by increasing the sample size, suggested by theoretical analysis. Photochromism ; Encryption ; Encapsulation (networking) ; Information storage ; Key (lock) ; Embedding ; Computer data storage Photochromic and Fluorescence Chemistry ; Luminescence and Fluorescent Materials ; Synthesis and Properties of Aromatic Compounds
Authors: Asma K. Alshamari | Ayshah Aysh ALrashidi | Faiza I. A. Abdella | Hamed M. Alshammari | Mona Zaheed Alshammari | Nuha Othman S. Alsaif | Tamer El Malah
Source: Journal of Saudi Chemical Society (article, 2025-07-01)
Field: Chemistry — Organic Chemistry

EGFR tyrosine kinase inhibitor: design, synthesis, characterization, biological evaluation, and molecular docking of novel 1,3,4-oxadiazole, thio-methyl, and 1,2,3-triazole hybrids Concerning the structural analysis and optimization of various potential EGFR inhibitors. A series of heterocyclic compounds incorporating pyridine, 1,3,4-oxadiazole, thio-methyl, and 1,2,3-triazole were successfully synthesized via a click reaction 12–21, resulting in high yields. The synthesis process entailed the reaction of terminal alkynes, specifically 2-(prop-2-yn-1-ylthio)-5-(pyridin-4-yl)-1,3,4-oxadiazole 1 with various substituted aryl azides 2–11. The cytotoxic properties of the resulting derivatives were assessed against HCT-116, HePG-2, and MCF-7 cancer cell lines. Notably, Compound 19 displayed the highest activity among the tested compounds, with selectivity towards the tumor cells, yielding IC50 values of low micromolar level. Consequently, a series of biological assays were conducted to elucidate the potential mechanism of action of the most potent derivative. Compound 19 demonstrated considerable suppression of EGFR, with an IC50 value of 0.313 µM. This highly effective EGFR inhibitor, Compound 19, halted the HePG-2 cell cycle at the G0/G1 phase by triggering the apoptotic pathway. Moreover, molecular docking illustrated a distinctive interaction of compound 19 with the EGFR binding pocket. This work ultimately presents new derivatives of 1,3,4-oxadiazole, thio-methyl, and 1,2,3-triazole as potential cytotoxic agents and EGFR inhibitors, which should be the subject of further research in tumor therapy. Thio- ; Oxadiazole ; Docking (animal) ; Chemistry ; Triazole ; Combinatorial chemistry ; Tyrosine-kinase inhibitor ; Stereochemistry ; Biology ; Organic chemistry ; Medicine ; Genetics Click Chemistry and Applications ; HER2/EGFR in Cancer Research ; Chemical Synthesis and Analysis
Authors: Suneel Kumar Srivastava
Source: RSC Applied Polymers (article, 2025-11-04)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Recent advances in hollow and core–shell intrinsically conducting polymers for applications in electromagnetic interference shielding/microwave absorption, removal of metal ions/dyes and supercapacitors Recent advancements on hollow intrinsically conducting polymers, their composites and core–shell structured materials are reviewed for their applications in the field of electromagnetic interference shielding/microwave absorption, removal of metal ions/dyes and supercapacitor. Conductive polymer ; Supercapacitor ; Electromagnetic interference ; Interference (communication) ; Electromagnetic field ; Polymer Electromagnetic wave absorption materials ; Conducting polymers and applications ; Polymer Nanocomposite Synthesis and Irradiation
Authors: Vijay Kumar Garlapati | Swati Sharma | Deepak K. Sharma | Sanjeev Kumar | Samuel Jacob | Arindam Kuila | Ashok K. Gupta | Abhishek Chaudhary
Source: Frontiers in Bioengineering and Biotechnology (review, 2025-09-17)
Field: Materials Science — Materials Chemistry

Sustainable production of microalgal nanoparticles through green synthesis towards cancer treatment Nanoparticle-based treatment is one of the rapidly growing research domains in cancer treatment due to its associated structural, targeted, and stability features. The conventional (chemical and physical) nanoparticle (NP) synthesis suffers from drawbacks such as toxicity, cost, and unsustainable process methodologies, which necessitate the urgent need for sustainable green approaches to nanoparticle synthesis for envisioned cancer treatment options. The green synthesis of microalgal NPs is a promising approach for obtaining NPs for cancer treatment. As a result, this review presents the synthesis mechanism of microalgal NPs and the factors affecting their green synthesis. The mechanism of action of microalgal NPs in cancer treatment has been discussed in relation to their cytotoxic effects. The sustainability features, probable quality control regime of green-synthesized microlgal NPs, along with the prospects of incorporating synthetic biology and utilizing genetically engineered microalgae, have been highlighted in the context of cancer treatment. Cancer treatment ; Context (archaeology) ; Cancer ; Cancer cell ; Nanoparticle ; Cancer therapy ; Sustainable production Nanoparticles: synthesis and applications ; Graphene and Nanomaterials Applications
Authors: Edoardo Testa | Vincenzina Barbera | Elisa Fasoli | Ulrich Giese | Maria R. Belviso | Pasqua Rossini | Daniele Bruno | Gianluca Tettamanti | Marco Orlando | Gianluca Molla | Morena Casartelli | Maurizio Galimberti
Source: ACS Sustainable Chemistry & Engineering (article, 2025-02-03)
Field: Materials Science — Biomaterials

Electroconductive Bionanocomposites from Black Soldier Fly Proteins for Green Flexible Electronics Printed and flexible electronics hold the potential to revolutionize the world of electronic devices. A primary focus today is their circularity, which can be achieved by using biobased materials. In this study, electrically conductive bionanocomposite materials suitable for flexible electronics were fabricated using proteins from the black soldier fly (BSF, <i>Hermetia illucens</i>). The valorization of BSF biomacromolecules is currently being pursued in the framework of emerging circular economy models for the bioconversion of the Organic Fraction of Municipal Solid Waste (OFMSW), where BSF has been demonstrated to act as an extremely efficient bioconverter to provide lipids, chitin, and proteins. Here, the BSF protein extracts were characterized by proteomic techniques, revealing a pool of myofibrillar proteins able to interact through intermolecular β-sheet interactions. Flexible and electroconductive bionanocomposite materials were next formulated by combining BSF proteins with a conductive carbon black (CCB), either in its pristine form or functionalized with 2-(2,5-dimethyl-1<i>H</i>-pyrrol-1-yl)-1,3-propanediol (serinol pyrrole, SP), using water as the only solvent and incorporating glycerol and carboxymethylcellulose (CMC) as additional green ingredients. A sustainable, low-pressure cold plasma (LPCP) technology was ultimately proposed to achieve high film surface hydrophobicity. Characterized by effective biodegradability, strain-sensing properties, high electrical conductivity (up to 0.9 × 10<sup>-2</sup> S/cm at a filler content of 8% v/v (15% w/w)), and high surface hydrophobicity, the bionanocomposites presented here may be well suited for disposable flexible electronics, as in wearable devices, electrostatic discharge fabrics, or packaging, hence offering new routes toward OFMSW valorization and the development of green flexible electronics. Carbon black ; Electronics ; Nanotechnology ; Materials science ; Business ; Composite material ; Engineering ; Electrical engineering Silk-based biomaterials and applications ; Advanced Sensor and Energy Harvesting Materials ; Additive Manufacturing and 3D Printing Technologies
Authors: Lixue Gai | Yongzheng Chen | Yan Wang | Xijiang Han | Ping Xu | Yunchen Du
Source: Journal of Advanced Ceramics (article, 2025-11-14)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Engineering impedance-matched double-shells in hollow Co/carbon microspheres with gradient graphitization for high-efficiency electromagnetic wave absorption The inherent trade-off between impedance matching and electromagnetic (EM) attenuation capability has long been a fundamental limitation in carbon-based materials, hindering further advances in their EM absorption performance. To overcome this challenge, we innovatively design hollow double-shell Co/carbon microspheres with a gradient graphitization structure, where Co<sub>3</sub>O<sub>4</sub> nanoparticles pre-anchored on melamine formaldehyde microspheres can induce the formation of graphitic inner shells during high-temperature pyrolysis, and nevertheless, the outer carbon shells remain amorphous nature due to the lack of Co-relate species, ultimately resulting in a gradient graphitization from the inside out. This unique double-shell architecture combines the advantages of both gradient graphitization and hollow structure, favorable for powerful EM attenuation and impedance matching at the same time. EM analyses reveal that the outer amorphous carbon shells not only play a key role in optimizing impedance matching, but also create heterogeneous interfaces with the inner graphitic shells to enhance interfacial polarization. As a result, the as-prepared sample achieves a superior reflection loss of -62.9 dB, and its maximum effective absorption bandwidth (EAB<sub>max</sub>) can be extended to 11.3 GHz through a rationally designed multilayer structure, significantly surpassing non-gradient counterparts. Computer simulation technology (CST) simulations further verify a remarkable radar cross-section (RCS) reduction of 22.3 dBm². This work provides an effective strategy for reconciling the conflict between impedance matching and attenuation in carbon-based materials, and also demonstrates their great potential as lightweight and broadband EM wave absorbing materials in the future. Attenuation ; Reflection loss ; Impedance matching ; Absorption (acoustics) ; Amorphous solid ; Nanoparticle ; Scattering ; Electrical impedance ; Amorphous carbon Electromagnetic wave absorption materials ; Advanced Antenna and Metasurface Technologies ; Metamaterials and Metasurfaces Applications
Authors: Yuanming Wang | Jinlong Wu | Jiayue Dong | Xiaoxu Xu | Huan Song | Libei Yuan | Xiaolong Li | Zhaoqing Lu
Source: Chemical Science (article, 2025-01-01)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Surface chemistry regulation of conductive two-dimensional nanosheets with highly pseudocapacitive covalent groups for a high-performance flexible asymmetric microsupercapacitor Flexible microsupercapacitors are attracting much more attention for use in miniature energy storage devices due to their attractive electrochemical characteristics. However, it is difficult to achieve high energy density and long-term stability at the same time due to a lack of suitable high-specific-energy materials. Herein, an innovative asymmetric microsupercapacitor is obtained by the highly efficient surface chemistry regulation of conductive two-dimensional nanosheets of both graphene and MXene with highly active covalent groups. To optimize the positive graphene material, graphene oxide powder is first employed, undergoing a fast expansion and exfoliation process <i>via</i> water molecule explosive vaporization. Then, the conductive graphene sheet layer with a high specific surface area is oxidized selectively by acid treatment to introduce pseudocapacitive groups at an optimized proportion and density (more -COOH and less -OH), and this is labelled as expanded-and-oxidized graphene (EOG). To optimize the negative MXene material, delaminated MXene nanosheets undergo hydroxyl substitution through alkalization, and the two-dimensional (2D) lamellae become wrinkled using coulombic attraction for fast intercalation pseudocapacitance, and this is labelled as wrinkled-and-hydroxylated MXene (WOM). Through surface chemistry modification and all-pseudocapacitive 2D structure design, flexible EOG and WOM composite electrodes exhibit capacities of 382 F g<sup>-1</sup> and 550 F g<sup>-1</sup>, respectively, and have remarkable stability. An assembled proton-type solid-state microsupercapacitor with a voltage window of 1.5 V readily achieves an energy density of 47.25 mW h cm<sup>-3</sup> (23.62 W h kg<sup>-1</sup>) at a power density of 1900.55 mW cm<sup>-3</sup> (950.27 W kg<sup>-1</sup>), with high capacity retention of 86.8% after 8000 cycles. This work shows a well-designed microdevice with flexible and integrable properties based on 2D microstructure engineering for use in flexible electronics. Graphene ; Exfoliation joint ; Oxide ; Covalent bond ; Intercalation (chemistry) ; Electrode ; Electrochemistry ; Composite number ; Stacking Supercapacitor Materials and Fabrication ; Graphene research and applications ; Nanomaterials for catalytic reactions
Authors: Maya Georgieva | Martin Sharkov | Emilio Mateev | Diana Tzankova | G Popov | Vasil Manov | Alexander Zlatkov | Rumyana Simeonova | Magdalena Kondeva-Burdina
Source: Molecules (article, 2025-07-28)
Field: Chemistry — Organic Chemistry

Classical Paal-Knorr Cyclization for Synthesis of Pyrrole-Based Aryl Hydrazones and In Vitro/In Vivo Evaluation on Pharmacological Models of Parkinson’s Disease Some studies performed in our laboratory on pyrrole and its derivatives pointed towards the enrichment of the evaluations of these promising chemical structures for the potential treatment of neurodegenerative conditions in general and Parkinson's disease in particular. A classical Paal-Knorr cyclization approach is applied to synthesize the basic hydrazine used for the formation of the designed series of hydrazones (<b>15a</b>-<b>15g</b>). The potential neurotoxic and neuroprotective effects of the newly synthesized derivatives were investigated in vitro using different models of induced oxidative stress at three subcellular levels (rat brain synaptosomes, mitochondria, and microsomes). The results identified as the least neurotoxic molecules, <b>15a</b>, <b>15d</b>, and <b>15f</b> applied at a concentration of 100 µM to the isolated fractions. In addition, the highest statistically significant neuroprotection was observed for <b>15a</b> and <b>15d</b> at a concentration of 100 µM using three different injury models on subcellular fractions, including 6-hydroxydopamine in rat brain synaptosomes, tert-butyl hydroperoxide in brain mitochondria, and non-enzyme-induced lipid peroxidation in brain microsomes. The <i>h</i>MAOA/MAOB inhibitory activity of the new compounds was studied at a concentration of 1 µM. The lack of a statistically significant <i>h</i>MAOA inhibitory effect was observed for all tested compounds, except for <b>15f</b>, which showed 40% inhibitory activity. The most prominent statistically significant <i>h</i>MAOB inhibitory effect was determined for <b>15a</b>, <b>15d</b>, and <b>15f</b>, comparable to that of selegiline. The corresponding selectivity index defined <b>15f</b> as a non-selective MAO inhibitor and all other new hydrazones as selective <i>h</i>MAOB inhibitors, with <b>15d</b> indicating the highest selectivity index of >471. The most active and least toxic representative (<b>15d</b>) was evaluated in vivo on Rotenone based model of Parkinson's disease. The results revealed no microscopically visible alterations in the ganglion and glial cells in the animals treated with rotenone in combination with <b>15d</b>. In vivo ; Aryl ; In vitro ; Parkinson's disease ; Pyrrole ; Chemistry ; Pharmacology ; Disease ; Combinatorial chemistry ; Stereochemistry ; Biochemistry ; Medicine ; Organic chemistry ; Biology ; Internal medicine ; Biotechnology Synthesis and Characterization of Pyrroles ; Cyclopropane Reaction Mechanisms ; Click Chemistry and Applications
Authors: Nadia Banitorfi Hoveizavi | Farzaneh Alihosseini | Sandro Lehner | Philipp Meier | Sabyasachi Gaan
Source: Journal of Materials Chemistry B (article, 2025-01-01)
Field: Materials Science — Biomaterials

Colorimetric pH-responsive nanofibrous hydrogels for <i>in vitro</i> monitoring of wound infection Effective wound management is crucial for improving patient outcomes, particularly through timely detection of infections and monitoring of wound conditions. Addressing this critical need, this research develops nanofibrous hydrogels integrated with an indicator dye for real-time monitoring of wounds <i>via</i> a colorimetric method. A new double network nanofibrous hydrogels based on polyvinyl alcohol (PVA) and a phosphine oxide-based pH-sensitive hydrogel (namely PVA/Gel-A) with improved properties were produced through electrospinning. Their properties were examined through SEM, ICP-OES, FTIR, surface zeta potential, and mechanical analysis. Scanning electron microscopy and Brunauer-Emmett-Teller analysis confirmed the presence of smooth, bead free nanofibers with a mesoporous structure. The swelling ratio and surface zeta potential analysis further demonstrated the presence of anionic-cationic interpenetrating polymer networks (IPNs) in PVA/Gel-A compared to pristine PVA and Gel-A alone. Increasing the Gel-A content enhances moisture absorption in a dual system of PVA/Gel-A nanofibrous hydrogels. Compared to pristine PVA nanofibers, the PVA/Gel-A (1 : 1) nanofibers displayed enhancements in elastic modulus, tensile strength, and elongation of 216%, 154.5%, and 58%, respectively. It shows considerable strength while maintaining ductility, which is essential for flexible and durable applications. Then, the dye-doped PVA/Gel-A nanofibrous hydrogels, using bromothymol blue (BTB) as a pH-sensitive dye, were fabricated with and without a complexing agent. Their colorimetric and release behaviors were evaluated at different pH levels. The cationic complexing agent effectively prevented dye leaching, releasing less than 10% and ensuring chemical stability and accurate pH sensing. These IPNs can visibly indicate wound infections, resulting in the development of colorimetric nanofibrous hydrogels that monitor pH variations for smart wound dressing applications. <i>In vitro</i> cytotoxicity assessment applying keratinocytes demonstrates no toxic effects, underscoring their potential for safe clinical applications. Self-healing hydrogels ; Wound dressing ; Wound healing ; In vitro ; Materials science ; Biomedical engineering ; Medicine ; Chemistry ; Surgery ; Polymer chemistry ; Composite material ; Biochemistry Electrospun Nanofibers in Biomedical Applications ; Hydrogels: synthesis, properties, applications ; Advanced Sensor and Energy Harvesting Materials
Authors: Sergii Kalytchuk | Tomáš Malina | Filip Mravec | Kateřina Poláková | Lukáš Zdražil | Štěpán Kment | Andrey L. Rogach | Michal Otyepka | Radek Zbořil
Source: Biosensors and Bioelectronics (article, 2025-09-24)
Field: Materials Science — Materials Chemistry

pH sensing and imaging in living cells based on fluorescence lifetime of carbon dot nanosensors The pH value is one of the most frequently measured chemical parameters, yet developing nanometric sensors capable of accurately mapping pH distribution and dynamics with high spatial and temporal resolution remains a significant challenge. Such sensors are vital for advancing our understanding of numerous physiological and pathological processes. Nanoparticle-based sensors, commonly referred to as nanosensors, represent a promising class of optical sensors, with fluorescence lifetime-based probes offering superior sensitivity and quantitative reliability. However, existing pH nanosensors relying on fluorescence lifetime are challenging to synthesize and often suffer from poor biocompatibility, narrow pH response ranges, low stability, and calibration-dependent performance. Here, we overcome these limitations by introducing a water-dispersible pH nanosensor based on fluorescence lifetime of colloidal carbon dots (CDs) derived via a one-step reaction from a single precursor Rhodamine B. These CDs are biocompatible, non-toxic, and stable in highly acidic/basic conditions, which makes them well-suited for intracellular applications. The intrinsic fluorescence lifetime of these CDs exhibits a pseudo-linear, self-referencing response across exceptionally broad pH range (1-11), driven by pH-induced transformations of their electronic structure occurring during protonation and deprotonation of CD surface. By applying micrometer-resolution, quantitative pH imaging via fluorescence lifetime imaging microscopy, we demonstrate how CDs are preferentially sequestered in lysosomes of human skin fibroblasts, enabling precise quantification of inhibitor-induced pH changes within these organelles. Our findings highlight a significant potential of the CD nanosensors for precise monitoring of lysosomal pH in living cells, offering broad utility in biomedical research and potential studies of pH-associated cellular dysfunction. Nanosensor ; Fluorescence ; Intracellular pH ; Fluorescence-lifetime imaging microscopy ; Rhodamine ; Protonation ; Fluorescence microscope ; Live cell imaging Carbon and Quantum Dots Applications ; Advanced biosensing and bioanalysis techniques ; Nanocluster Synthesis and Applications