jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: H.P. Li | Xuliang Qian | Harini Mohanram | Xiao Han | Huitang Qi | Guijin Zou | Fenghou Yuan | Ali Miserez | Qing Yang | Tian Liu | Huajian Gao | Jing Yu
Source: bioRxiv (Cold Spring Harbor Laboratory) (preprint, 2023-07-19)
Field: Materials Science — Biomaterials

Harnessing Gradients for Self-Assembly of Peptide-Based Nanocapsules: A Pathway to Advanced Drug Delivery Systems Abstract Biological systems often create materials with intricate structures to achieve specialized functions. In comparison, precise control of structures in man-made materials has been challenging. Here, we report a serendipitous discovery of insect cuticle peptides (ICPs) spontaneously forming nanocapsules through a single-step solvent exchange process, where the concentration gradient resulting from mixing of water and aceton drives the localization and self-assembly of the peptides into hollow nanocapsules. The underlying driving force is the intrinsic affinity of the peptides for a particular solvent concentration, while the diffusion of water and acetone creates a gradient interface that triggers peptide localization and self-assembly. This gradient-mediated self-assembly offers a transformative pathway towards next-generation drug delivery systems based on peptide nanocapsules. Nanocapsules ; Peptide ; Drug delivery ; Nanotechnology ; Self-assembly ; Biophysics ; Chemistry ; Materials science ; Combinatorial chemistry ; Biochemistry ; Nanoparticle ; Biology Supramolecular Self-Assembly in Materials ; Lipid Membrane Structure and Behavior ; Polydiacetylene-based materials and applications
Authors: Biplab Biswas
Source: INTERNATIONAL JOURNAL OF RESEARCH AND ANALYTICAL REVIEWS (article, 2023-01-01)
Field: Chemistry — Inorganic Chemistry

A Short Review on the Applications of Metal-Schiff Base Complexes in the Field of Catalysis and Magnetic Materials UGC-CARE list, New UGC-CARE Reference List, UGC CARE Journals, ugc care list of journal, ugc care list, UGC Approved list, list of ugc approved journal, ugc approved journal,IJRAR - international Research Journal,IJRAR.ORG,Ijrar.org, International Journal of Research and Analytical Reviews (IJRAR) , UGC Approved journal, ugc approved,ugc, ugc certify, publish free of cost, free publication, UGC and ISSN Approved , International Peer Reviewed, Open Access Journal , e ISSN 2348 –1269, Print ISSN 2349-5138, ISSN: 2348 –1269, Impact Factor : 5.75 , E- journal, Low Cost INR 500, Free Publication Schiff base ; Catalysis ; Base metal ; Metal ; Field (mathematics) ; Base (topology) ; Chemistry ; Materials science ; Polymer chemistry ; Metallurgy ; Organic chemistry ; Mathematics Metal-Organic Frameworks: Synthesis and Applications ; Polyoxometalates: Synthesis and Applications ; Catalysis and Hydrodesulfurization Studies
Authors: Lucy Lu Wang
Source: International journal of high school research (article, 2023-01-25)
Field: Chemistry — Organic Chemistry

Small Molecule-Drug Conjugates: Targeted Tunable Therapy for Cancer Treatment Cancer is one of the leading causes of death worldwide, with over 1.6 million people affected yearly in the U.S. alone. Common treatments such as chemotherapy harm healthy cells and bring dangerous side effects. In the search for safer solutions, scientists have turned to a new field of study: targeted therapy. In the past decade, attention has shifted to the use of substances able to specifically target and identify cancer cells, minimizing harsh side effects and damage to healthy organs. With the success of targeted therapy like antibody-drug conjugates, a new area of research known as small molecule-drug conjugates has risen. A relatively new field, small molecule-drug conjugates are a more cost-effective and efficient treatment for eliminating cancer. Drug ; Conjugate ; Cancer ; Medicine ; Cancer therapy ; Pharmacology ; Internal medicine Click Chemistry and Applications ; Nanoparticle-Based Drug Delivery ; Synthesis and biological activity
Authors: Mr. Jagdish Subhash Gejage | Sanjay K. Bais | Mrs. Pradnya H. Gadhire
Source: International Journal of Advanced Research in Science Communication and Technology (article, 2023-01-31)
Field: Chemistry — Spectroscopy

Advanced Herbal Technology Due to their numerous benefits, herbal medications are increasingly attracting people's attention. As treatment options for many disorders, herbal formulations have gained widespread acceptance. Over 80% of the world's population relies on herbal products and medications for a healthy lifestyle, despite the fact that the majority of these uses are unconventional. As the usage of herbal goods has increased, so have the misuse and adulteration of the products, which has disappointed customers and producers and, in some cases, had disastrous results. The creation of reliable analytical techniques that can profile the phytochemical composition with accuracy, including quantitative studies of marker/bioactive chemicals and other important elements, is a significant challenge for scientists. Standardization is a critical essential step in the development ofa quality assurance process, a consistent chemical profile, or simply a constant biological activity for the manufacture and manufacturing of herbal medications. The numerous convectional approaches and more recent advancements are covered in the current review article. Recent developments have been noted in the areas of DNA fingerprinting, metabolomics, differential pulse polarography, chemometrics, X-ray diffraction, etc. Contributions of chromatographic and capillary electrophoresis methods to the standardisation of herbal medicines are also described. Standardization ; Traditional medicine ; Medicine ; Population ; Phytochemical ; Manufacturing process ; Risk analysis (engineering) ; Biochemical engineering ; Business ; Computer science ; Engineering ; Environmental health ; Materials science Analytical Chemistry and Chromatography ; Heavy Metals in Plants ; Analytical Methods in Pharmaceuticals
Authors: Yihui Xie | Danni Luo | Jesse Wiener | Alexander B. Koval | Conrad T. Pfeiffer | Christian E. Schafmeister
Source: Angewandte Chemie (article, 2023-04-19)
Field: Materials Science — Biomaterials

Spiroligomer‐Based Macrocycles for Atomically Precise Membranes Abstract Here, we report a new class of peptidomimetic macrocycles with well‐defined three‐dimensional structures and low conformational flexibility. They are assembled from fused‐ring spiro‐ladder oligomers (spiroligomers) by modular solid‐phase synthesis. Two‐dimensional nuclear magnetic resonance confirms their shape persistency. Triangular macrocycles of tunable sizes assemble into membranes with atomically precise pores, which exhibit size and shape‐dependent molecular sieving towards a series of structurally similar compounds. The exceptional structural diversity and stability of spiroligomer‐based macrocycles will be explored for more applications. Peptidomimetic ; Membrane ; Flexibility (engineering) ; Modular design ; Ring (chemistry) ; Materials science ; Crystallography ; Nanotechnology ; Chemistry ; Peptide ; Computer science ; Organic chemistry ; Mathematics Supramolecular Self-Assembly in Materials ; Metal-Organic Frameworks: Synthesis and Applications ; Supramolecular Chemistry and Complexes
Authors: Hussein I. Mahdi | Nabeel A. Bakr | Tagreed M. Al‐Saadi
Source: arXiv (Cornell University) (preprint, 2023-01-04)
Field: Materials Science — Materials Chemistry

Preparation and Characterization of NixMn0.25-xMg0.75Fe2O4 Nano-ferrite as NO2 Gas Sensing Material NixMn0.25-xMg0.75Fe2O4 nano-ferrites (where x = 0.00, 0.05, 0.10, 0.15 and 0.20) were produced via sol-gel auto-combustion technique. Investigations were done into how the incorporation of Ni ions affects the Mn0.25Mg0.75Fe2O4 ferrite's structure, morphological, magnetic, and NO2 gas sensing features. All the samples are single-phase, based on the structural study utilizing the X-ray diffraction (XRD) pattern. In terms of the structure of the cubic spinel, according to the XRD study, the crystallite sizes range from 24.30 to 28.32 nm, indicating nano-crystallinity. The synthesis of spherical nanoparticles with a small modification in particle size distribution was verified via FE-SEM images. The study found that the size of particles is tiny enough to act superparamagnetically. The area of hysteresis loop is almost non-existing, thus reflecting typical soft magnetic materials according to magnetic measurements by VSM carried out at room temperature. Furthermore, the conductance responses of the NixMn0.25-xMg0.75Fe2O4 nano-ferrite were measured by exposing the ferrite to oxidizing (NO2) gas at different operating temperatures. The results show that the sensor boasts shorter response and recovery times, as well as a higher sensitivity 707.22% of the sample (x=0.20) for nano-ferrite. Materials science ; Crystallinity ; Ferrite (magnet) ; Spinel ; Crystallite ; Nano- ; Nanoparticle ; Oxidizing agent ; Analytical Chemistry (journal) ; Microstructure ; Chemical engineering ; Particle size ; Composite material ; Nanotechnology ; Metallurgy ; Chemistry ; Chromatography Magnetic Properties and Synthesis of Ferrites ; Gas Sensing Nanomaterials and Sensors ; Electrochemical sensors and biosensors
Authors: Yujie Zheng | Yu Li | Changsheng Ke | Mojie Duan | Chaohui Ye | Xin Zhou | Minghui Yang | Zhong‐Xing Jiang | Shizhen Chen
Source:  (preprint, 2023-08-22)
Field: Materials Science — Materials Chemistry

Jellyfish-Inspired Smart Tetraphenylethene Lipids with Unique AIE Fluorescence, Thermal Response, and Cell Membrane Interaction Smart lipids with fluorescence emission, thermal response, and polyethylene glycolation (PEGylation) functions can be highly valuable for formulation, image-traceable delivery, and targeted release of payloads. Herein, a series of jellyfish-shaped amphiphiles with a tetraphenylethene (TPE) core and four symmetrical amphiphilic side chains were conveniently synthesized and systematically investigated as smart lipids. Compared with regular amphiphilic TPEs and phospholipids, the unprecedented jellyfish-shaped molecular geometry was found to enable a series of valuable capabilities, including sensitive and responsive aggregation-induced emission of fluorescence (AIE FL) with high quantum yields, efficient encapsulation of drugs into stable nanoparticles, PEGylation of nanoparticles with thermally responsive drug release, and real-time FL monitoring of drug uptake. Furthermore, the jellyfish-shaped geometry facilitated the concentration-dependent aggregation of unimolecular micelles into “side-by-side” assembled nanoparticles with a unique mode of AIE. In addition, the size and the arrangement of the amphiphilic side chains were found to dominate the aggregate stability, cell uptake, and thus the cytotoxicity of the amphiphiles. The study has unprecedentedly developed versatile smart TPE lipids with precise structures, unique physicochemical and biological properties, and great potential in biomedicine, which peculiar structure-property relationship may shed new light on the design and application of AIE fluorophores and functional lipids in biomedicine and materials science. Amphiphile ; PEGylation ; Fluorescence ; Chemistry ; Nanotechnology ; Nanoparticle ; Drug delivery ; Aggregation-induced emission ; Micelle ; Side chain ; Biophysics ; Materials science ; Organic chemistry ; Polymer ; Polyethylene glycol ; Copolymer Luminescence and Fluorescent Materials ; Molecular Sensors and Ion Detection ; Nanoplatforms for cancer theranostics
Authors: Dharmesh Trivedi | Seema Joshi | Amit Kumar Jain | Sagar Suresh Jadkar | Rahul I. Jadhav | Gajendra S Rathore | Anshu Sharma
Source: International Journal of Pharmaceutical Quality Assurance (review, 2023-09-25)
Field: Materials Science — Biomaterials

Potential Applications of Alpha Nanocellulose from Cow Dung in Biomedicine: A Comprehensive Review It is feasible to extract nanocellulose, in particular alpha nanocellulose, from agricultural waste products such as cow dung. This is the case. Nanocellulose of this particular form exhibits unique properties, making it an excellent candidate for biological applications. This review aims to discuss the biomedical applications of cow dung-derived alpha nanocellulose. Nanocellulose has a larger surface area, greater mechanical strength, and better biocompatibility than other cellulose nanomaterials. It starts off by walking through the process of removing nanocellulose from cow manure. Alpha nanocellulose has applications in tissue engineering, the administration of medicines, the healing of wounds, as well as biosensing. Each application is broken down into its component parts, providing insights into the underlying mechanisms, experimental investigations, as well as in-vitro and in-vivo evaluations to establish the viability and effectiveness of alpha nanocellulose. The review paper also discusses the difficulties encountered and the potential future applications of alpha nanocellulose derived from cow dung in biomedicine. These difficulties include the requirement for standardized extraction processes, the optimization of material properties, and the consideration of regulatory issues. This in-depth study demonstrates that alpha nanocellulose that is generated from cow dung is a versatile and environmentally friendly nanomaterial that can be used for medical applications. It is hoped that the findings of this study will inspire more research and creative applications based on the unique properties of alpha nanocellulose, possibly resulting in biomedical breakthroughs by consolidating knowledge and exploring new areas. Nanocellulose ; Nanotechnology ; Biomedicine ; Biocompatibility ; Materials science ; Biochemical engineering ; Biotechnology ; Cellulose ; Engineering ; Biology ; Bioinformatics ; Chemical engineering Advanced Cellulose Research Studies
Authors: Te Liu | Sichao Huang | Qian Zhang | Yu Xia | Manjie Zhang | Bin Sun
Source: bioRxiv (Cold Spring Harbor Laboratory) (preprint, 2023-09-19)
Field: Materials Science — Materials Chemistry

Reconciling ASPP-p53 Binding Mode Discrepancies through an Ensemble Binding Framework that Bridges Crystallography and NMR Data Abstract ASPP2 and iASPP bind to p53 through their conserved ANK-SH3 domains to respectively promote and inhibit p53-dependent cell apoptosis. While crystallography has indicated that these two proteins employ distinct surfaces of their ANK-SH3 domains to bind to p53, solution NMR data has suggested similar surfaces. In this study, we employed multi-scale molecular dynamics (MD) combined with free energy calculations to reconcile the discrepancy in the binding modes. We demonstrated that the binding mode based solely on a single crystal structure does not enable iASPP’s RT loop to engage with p53’s C-terminal linker—a verified interaction. Instead, an ensemble of simulated iASPP-p53 complexes facilitates this interaction. We showed that the ensemble-average inter-protein contacting residues and NMR-detected interfacial residues align well with ASPP proteins, and the ensemble-average binding free energies better match experimental Kd values compared to single crystallgarphy-determined binding mode. For iASPP, the sampled ensemble complexes can be grouped into two classes, resembling the binding modes determined by crystallography and solution NMR. We thus propose that crystal packing shifts the equilibrium of binding modes towards the crystallographydetermined one. Lastly, we show that the ensemble binding complexes are sensitive to p53’s intrinsically disordered regions (IDRs), attesting to experimental observations that these IDRs contribute to biological functions. Our results provide a dynamic and ensemble perspective for scrutinizing these important cancer-related protein-protein interactions (PPIs). Linker ; Crystallography ; Plasma protein binding ; Binding site ; Binding energy ; Molecular dynamics ; Chemistry ; Crystal structure ; Protein structure ; Biophysics ; Physics ; Biology ; Biochemistry ; Computational chemistry ; Computer science Enzyme Structure and Function ; Protein Structure and Dynamics ; Cancer-related Molecular Pathways
Authors: Yuxia Pang | Yingdong Luo | Zhiping Li | Yan‐Ling Luo | Hongming Lou | Mingsong Zhou
Source: Research Square (preprint, 2023-07-21)
Field: Materials Science — Materials Chemistry

Pickering emulsion stabilized by lignin particles: influence of oil phase, lignin concentration and particle size <title>Abstract</title> Pickering emulsion stabilized by lignin particles has many advantages such as high flexibility, natural non-toxicity, anti-oxidation and anti-ultraviolet. In order to promote the application of industrial lignin in the field of Pickering emulsions, this study has done a comparatively systematic and basic research on Pickering emulsions stabilized by lignin particles. The emulsification effects of lignin particles on cyclohexane and n-decanol which have opposite polarity were compared firstly under different oil-water ratios. It was found that stable emulsions formed when the three-phase contact angle of oil/water/lignin was closer to 90°. The weakly polar cyclohexane could be well-emulsified by lignin particles, while the strong polar n-decanol could hardly be. Cyclohexane was used as the oil phase to discuss the emulsification ability of lignin particles under different concentration or with different particle size. The results show increasing the concentration of lignin particles or reducing the particle size can improve the emulsification performance. Lignin ; Pickering emulsion ; Cyclohexane ; Chemical engineering ; Emulsion ; Particle size ; Materials science ; Particle (ecology) ; Phase (matter) ; Organic chemistry ; Chemistry Pickering emulsions and particle stabilization ; Lignin and Wood Chemistry ; Proteins in Food Systems
Authors: Sang-In Lee | Min-Guk Seo | June Huh | Hyun‐jong Paik
Source: Polymers (article, 2023-06-30)
Field: Chemistry — Organic Chemistry

Effective Interaction between Homo- and Heteropolymer Block of Poly(n-butyl acrylate)-b-poly(methyl methacrylate-r-styrene) Diblock Copolymers We investigated the segregation behavior of a molten diblock copolymer, poly(<i>n</i>-butyl acrylate)-<i>b</i>-poly(methyl methacrylate-<i>r</i>-styrene) (PBA-<i>b</i>-P(MMA-<i>r</i>-S)), wherein styrene (S) is incorporated as a comonomer in the second block to modulate the effective interaction between homopolymer and a random copolymer block. The temperature dependence of the effective interaction parameter χeff between <i>n</i>-butyl acrylate (BA) and the average monomer of the MMA-<i>r</i>-S random block was evaluated from small-angle X-ray scattering (SAXS) analysis using the random phase approximation (RPA) approach. The calculated χeff, as a function of the styrene fraction in the random copolymer block, shows a good agreement with the mean-field binary interaction model. This consistency indicates that the effective interaction between component BA and the average monomer of the random copolymer block is smaller than the interactions between pure components (χBA,MMA,χBA,S). The present study suggests that the introduction of a random copolymer block to a block copolymer can effectively reduce the degree of incompatibility of the block copolymer system without altering the constituent species, which may serve as a viable methodology in designing novel thermoplastic elastomers based on triblock or multiblock copolymers. Copolymer ; Comonomer ; Materials science ; Random phase approximation ; Polymer chemistry ; Styrene ; Methyl methacrylate ; Monomer ; Acrylate ; Small-angle X-ray scattering ; Butyl acrylate ; Thermoplastic elastomer ; Methacrylate ; Flory–Huggins solution theory ; Polymer ; Scattering ; Composite material ; Physics Advanced Polymer Synthesis and Characterization ; Block Copolymer Self-Assembly ; Polymer crystallization and properties
Authors: Mateusz Weisbrodt | Agnieszka Kowalczyk | Beata Schmidt | Tomasz J. Idzik | Jacek G. Sośnicki
Source: Materials (article, 2023-12-14)
Field: Chemistry — Organic Chemistry

Functional Acrylic Resins Prepared via Photo-Induced Telomerization Using Tetrabromomethane as Telogen Novel method of obtaining functional acrylic resins (FARs) containing carboxyl- and benzophenone groups (in-chain functionalization) and terminal Br atoms was verified. Acrylic oligomers were prepared by a solution-free, UV-initiated telomerization process of basic monomer (n-butyl acrylate) and functional monomers (acrylic acid and 4-acrylooxybenzophenone) in the presence of radical photoinitiator and different amount of tetrabromomethane (CBr<sub>4</sub>) as telogen. The effect of telogen content on UV-telomerization kinetics as well as physicochemical and thermal (T<sub>g</sub>) properties of FARs was investigated. A telogen content higher than 5 wt. parts does not affect the UV-telomerization rate (photo-DSC), the molecular weights of telomers (GPC), or their glass transition temperature (DSC), but it significantly increases the conversion of monomers (up to 88%) and lowers the viscosity of FARs (approx. 6 Pa·s). NMR studies confirmed the inclusion of CBr<sub>4</sub> in the structure of functional acrylic telomers. Telomerization ; Monomer ; Photoinitiator ; Polymer chemistry ; Acrylic acid ; Acrylate ; Acrylic resin ; Benzophenone ; Glass transition ; Chemistry ; Materials science ; Organic chemistry ; Polymer ; Catalysis Photopolymerization techniques and applications ; Advanced Polymer Synthesis and Characterization ; Photochromic and Fluorescence Chemistry
Authors: Xuan Liang | Shan Qian | Zhizheng Lou | Renming Hu | Yu‐Chen Hou | Peng R. Chen | Xinyuan Fan
Source: ChemRxiv (preprint, 2023-04-03)
Field: Chemistry — Organic Chemistry

NIR-triggered photocatalytic decaging for remote-controlled spatiotemporal activation in living mice Spatiotemporal manipulation of biological processes in living animals using non-invasive, remote-controlled stimuli is a captivating but challenging endeavor. Herein, we present the development of a bioorthogonal photocatalytic technology termed CAT-NIR, which uses external near infrared light (NIR, 740 nm) to trigger bioorthogonal chemical decaging reactions in living mice. The Os(tpy)2 complex was identified as an efficient NIR photocatalyst for promoting deboronative hydroxylation reactions in the presence of NIR lights, resulting in the deprotection of phenol groups and the release of bioactive molecules under bioorthogonal conditions. The validation of the CAT-NIR system was demonstrated through the NIR-triggered rescue of fluorophores, prodrugs as well as biomolecules ranging from amino acids, peptides to proteins in living cells. Furthermore, by combining genetic code expansion and computer-aided screening, CAT-NIR was able to regulate affibody binding to the cell surface receptor Her2 in living cells, providing a highly selective cell tagging technology with spatiotemporal precision through external NIR light. Most significantly, the tissue-penetrating ability of NIR light allowed for smooth prodrug activation in living mice using external NIR light, enabling non-invasive, remote-controlled rescue of bioactive molecules. This opens up new opportunities for in vivo investigations and manipulations given the broad adaptability of the decaging chemistry and the high spatiotemporal resolution potential of such photocatalytic tools. Bioorthogonal chemistry ; Biomolecule ; Prodrug ; Small molecule ; Chemistry ; In vivo ; Near-infrared spectroscopy ; Hydroxylation ; Biophysics ; Nanotechnology ; Combinatorial chemistry ; Biochemistry ; Materials science ; Biology ; Click chemistry ; Enzyme ; Biotechnology ; Neuroscience Click Chemistry and Applications ; Virus-based gene therapy research ; Cancer Research and Treatments