jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Palma Robert Amosa Lemi | Gurbachan Lal | Neeru Singh
Source: International Journal of Research and Applied Innovations (article, 2026-03-11)
Field: Materials Science — Biomaterials

Liposome-Based Drug Delivery Systems for Targeted Treatment of Breast Cancer Liposome-based drug delivery systems have emerged as an effective nanotechnological strategy to overcome these limitations by improving drug solubility, stability, pharmacokinetics, and tumor targeting. Liposomes are biocompatible phospholipid vesicles capable of encapsulating both hydrophilic and hydrophobic anticancer agents, enabling controlled drug release and reduced off-target effects. This review provides a comprehensive overview of liposome-based drug delivery systems for targeted treatment of breast cancer. It discusses breast cancer pathophysiology and molecular targets relevant to liposomal design, followed by an in-depth analysis of liposome structure, formulation strategies, and physicochemical properties influencing therapeutic performance. Passive targeting via the enhanced permeability and retention (EPR) effect, active ligand-mediated targeting, and stimuli-responsive liposomal systems are critically examined. The review further highlights therapeutic applications including liposomal chemotherapeutics, combination drug delivery, and gene/siRNA delivery approaches. In vivo pharmacokinetics, biodistribution, clinical progress of approved liposomal formulations, and ongoing clinical developments are also discussed. Additionally, safety, toxicity, and regulatory considerations are addressed, along with key challenges hindering clinical translation. Finally, emerging trends such as multifunctional liposomes, personalized nanomedicine, and scalable manufacturing strategies are explored. Overall, liposome-based drug delivery systems represent a promising and clinically relevant platform for improving the efficacy and safety of breast cancer therapy. Drug delivery ; Liposome ; Breast cancer ; Drug ; Targeted drug delivery ; Biocompatible material ; Clinical trial ; Drug carrier Nanoparticle-Based Drug Delivery ; RNA Interference and Gene Delivery ; Cancer Research and Treatment
Authors: Yiming Ma | Z. G. Huang | Yuanbo Wang | Sheng Lu | Fang Wang | Bin Wu | Xiaoqiang Chen
Source: AIChE Journal (article, 2026-01-26)
Field: Chemistry — Organic Chemistry

Dual‐cysteine tag‐directed fluorescence platform for high‐throughput screening of <i>E. coli</i> protein expression systems Abstract Methods for accurate and efficient protein quantification are crucial in the fields of biomanufacturing, synthetic biology and protein development for optimizing related bioprocesses. Herein, we developed a fluorescent probe, FL‐NO 2 , composed of fluorescein linked to dinitroethylene groups, enabling site‐specific covalent labeling of cysteine residues. This probe exhibits high specificity for CPGC‐tagged proteins, and the impacts of the location of the inserted dual‐Cysteine tag, as well as the introduction of a flexible GGGGS linker, on the protein activity and the labeling efficiency were investigated to extend the practical applicability of this fluorescent tool. Using FL‐NO 2 as a fluorescence‐guided expression platform for in situ protein detection during bacterial fermentation allowed the key parameter optimization. Moreover, this fluorescence‐guided platform enabled high‐throughput screening of promoter libraries overcoming the labor‐intensive limitations of traditional protein expression analysis. This work provides a platform that facilitates the development of in situ protein quantification and high‐throughput protein engineering techniques. Protein expression ; Fluorescent protein ; Fluorescence ; Green fluorescent protein ; In situ ; Protein engineering ; Covalent bond ; Target protein ; Cysteine Click Chemistry and Applications ; Biotin and Related Studies ; Chemical Synthesis and Analysis
Authors: Shuai Luo | Beibei He | Li Wang | Luyao Zhao | W. W. Wang
Source: Biomolecules (article, 2026-03-12)
Field: Chemistry — Organic Chemistry

Lipid Deterioration Mitigation in Brown Rice Milled from Long-Term Stored Paddy by Microwave: A Lipidomic Perspective The utilization of brown rice from long-term stored paddy is severely limited by lipid deterioration, which is primarily characterized by a high free fatty acid value (FAV). Although microwave treatment shows promise in mitigating lipid deterioration, its underlying mechanism in degraded grains remains poorly understood. This study systematically investigated the efficacy and mechanism of microwave treatment using a multi-analytical approach. Brown rice from long-term stored paddy (<i>Longjing-46</i>, stored for 6 years) was treated using a laboratory microwave oven (420 W or 560 W, 1-5 min). The reduction in FAV was quantified, lipid structural changes were analyzed by FT-IR spectroscopy, and lipid metabolic alterations were profiled using untargeted lipidomics. Results showed that microwave treatment significantly reduced FAV in a time- and power-dependent manner, with a maximum reduction of 76.3%. Treatment at 420 W for 4 min was identified as the optimal condition. FT-IR analysis confirmed that the treatment inhibited lipid oxidation and hydrolysis at the molecular level. Importantly, lipidomics revealed that the mechanism extended beyond simple enzyme inactivation. Microwave treatment induced a reprogramming of the lipid metabolic network, characterized by the synergistic downregulation of key lipid species and the activation of the autophagy pathway. This study provides a comprehensive, lipid-centric explanation of microwave-mediated quality improvement in long-term stored brown rice, integrating enzyme inactivation with metabolic network reprogramming. The findings offer a novel scientific basis for applying this technology to valorize degraded grain stocks, contributing to the reduction in postharvest loss. Brown rice ; Postharvest ; Lipidomics ; Lipid metabolism ; Lipid oxidation ; Enzyme Edible Oils Quality and Analysis ; Food composition and properties ; Food Drying and Modeling
Authors: Jiawen Huang | YaTing Zheng | Zhibin Ye | Xi Mao
Source: Frontiers in Materials (article, 2026-02-06)
Field: Materials Science — Polymers and Plastics

Study on the mechanical properties of plant fiber reinforced concrete: the relationship between incorporation methods and performance Plant fiber-reinforced concrete is gaining increasing attention due to its potential to enhance sustainability and improve mechanical properties. Among various plant fibers, reed fibers have shown promise in reinforcing concrete. However, the impact of different fiber addition sequences on the mechanical performance of concrete is not yet fully understood. This study investigates the effect of different addition sequences of reed fibers on the mechanical properties of concrete. Ordinary Portland cement was used as the base material, incorporating 0.5% by volume of 20 mm-long reed fibers. Four different addition sequences were designed: dry fiber pre-mix, dry fiber post-addition, surface-dried saturated fiber pre-mix, and surface-dried saturated fiber post-addition. Compressive strength, splitting tensile strength, and flexural strength tests were performed to evaluate the mechanical properties and strength development of concrete. The results indicate that the surface-dried saturated fiber post-addition method exhibited the optimal mechanical performance. This method improves fiber-cement particle interaction during the mixing stage, leading to a more stable interfacial bond and higher strength in compressive, flexural, and splitting tensile tests. Based on the experimental results, this study identifies surface-dried saturated post-addition as the most suitable addition sequence for reed fiber reinforced concrete, offering valuable insights for optimizing production processes and enhancing the performance of plant fiber reinforced concrete. Fiber ; Flexural strength ; Ultimate tensile strength ; Compressive strength ; Portland cement ; Mixing (physics) ; Fiber-reinforced concrete Natural Fiber Reinforced Composites ; Innovative concrete reinforcement materials ; Bamboo properties and applications
Authors: Mert Bekir Atsever | Serhan Yarkan | Mehmet Hakan Hocaoğlu
Source: Journal of Naval Sciences and Engineering (article, 2026-04-08)
Field: Materials Science — Materials Chemistry

EFFECT OF THE CABLE CROSS-SECTION FOR LOCATING PARTIAL DISCHARGES IN UNDERGROUND XLPE CABLES Partial discharge (PD) frequently occurs in underground cables. Gradually, these discharges can lead to permanent and hazardous faults, causing severe damage to the cable insulation and distribution in the service quality. Therefore, it is crucial to accurately locate PD sources and intervene before they evolve into irreversible failures. PD location can be determined using fundamental traveling wave equations. Therefore, cable cross-section significantly affects the cable parameters and eventually performance of PD localization method is hindered. In this study, it was observed that identical PD sources yielded different location estimates when cable cross-sections are varied. These results were demonstrated through a comprehensive simulation model of a cable feeder developed in EMTP-ATP Draw program using actual field data. Partial discharge ; Field (mathematics) ; Current (fluid) ; Direct-buried cable ; Cable gland High voltage insulation and dielectric phenomena ; Thermal Analysis in Power Transmission ; Lightning and Electromagnetic Phenomena
Authors: Vanja Mandrić | Slavko Rupčić | Bogdan Pavković | Ismail Baxhaku
Source:  (article, 2026-01-28)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Transmission of EM Waves Passing Through a Multilayer Structure This article investigates the behavior of an electromagnetic field passing through a composite material—a multilayered structure. The material consists of a dielectric material polymethyl methacrylate (acrylic, plexiglass) to which one or more layers of conductive paint are applied to attenuate the field strength. This field attenuation is possible precisely because of the chemical structure of the paint, which contains carbon-based particles and is therefore very successful in its purpose. Research was carried out with the stated aim—simulations and confirmation by measurements—to investigate the attenuation of the EM field when passing through a multi-layered structure. Attenuation ; Polymethyl methacrylate ; Dielectric ; Electromagnetic field ; Field (mathematics) ; Electrical conductor ; Transmission (telecommunications) ; Electromagnetic radiation Electromagnetic wave absorption materials ; Aerosol Filtration and Electrostatic Precipitation ; Electromagnetic Scattering and Analysis
Authors: Danni Shan | Diya Xie | Liping Zeng | Jianquan Wang | Zhiyong Wang
Source: Biomaterials Science (article, 2026-01-01)
Field: Materials Science — Biomaterials

Rational design of a targeted theranostic nanoagent for sequential application during oral squamous cell carcinoma surgery Oral squamous cell carcinoma (OSCC) is a common cancer of the head and neck, and its treatment outcome depends strongly on whether the tumor is completely removed during surgery. Current tools for preoperative imaging, intraoperative guidance, and postoperative treatment are not well connected, which makes it difficult for surgeons to accurately identify tumor margins and manage residual cancer. Here, we developed a theranostic nanoplatform called AuNPs/HSA-ICG. It is made by loading indocyanine green (ICG) and gold nanoparticles (AuNPs) onto human serum albumin (HSA). This system combines three functions in one: preoperative computed tomography (CT) imaging, intraoperative near-infrared fluorescence guidance, and postoperative photodynamic therapy (PDT). The nanoplatform shows good fluorescence stability, strong CT contrast, and specific tumor-targeting capability attributable to secreted protein acidic and rich in cysteine (SPARC)-mediated active uptake. In an orthotopic tongue cancer model, the combined CT and fluorescence imaging allowed accurate tumor localization and clear visualization of surgical margins, facilitating complete tumor removal. In a residual tumor model simulating positive margins, ICG-based PDT effectively suppressed tumor regrowth. Safety evaluations showed good biocompatibility and low systemic toxicity. Overall, this study presents a clinically translatable, integrated strategy for precise surgical margin management in OSCC, spanning the entire perioperative course. Rational design ; Basal cell ; Perioperative ; Indocyanine green ; Head and neck squamous-cell carcinoma ; Surgical margin ; Fluorescence-lifetime imaging microscopy ; Head and neck cancer ; Image-guided surgery Nanoparticle-Based Drug Delivery ; Graphene and Nanomaterials Applications ; Nanoplatforms for cancer theranostics
Authors: Guilherme Aguiar Mateus Pasquali | Belén Nieto‐Ortega | J. M. Arroyo | Natalia Castañares | Kostas Stamatopoulos | Adam Smith
Source: Frontiers in Animal Science (article, 2026-02-10)
Field: Chemistry — Analytical Chemistry

Rapid estimation of non-starch polysaccharides and lignin in monogastric feed ingredients using near-infrared spectroscopy The fiber composition in protein meals and by-products is highly variable and is influenced by plant genetics, environmental conditions, and processing. Therefore, enabling the rapid analysis of fiber in various ingredients can support the inclusion of fiber-rich ingredients in monogastric diets. This study aimed to develop and validate near-infrared reflectance spectroscopy (NIRS) calibrations for predicting non-starch polysaccharides (NSP), lignin, and related components in feed ingredients. In this study, 628 samples of diverse feed ingredients and by-products were collected globally between 2015 and 2022. Chemical analyses were conducted to determine the NSP content, including total and insoluble NSP, as well as the monosaccharide sugars. Separate assays were also conducted to determine the cellulose and lignin contents. The same samples were screened using NIRS to predict the NSP, mono-component sugar (e.g., xylose, glucose, and mannose), and cellulose and lignin contents. The diversity in raw materials enabled the development of a global NIRS calibration for the NSP fractions, cellulose, lignin, and key monosaccharides. Global calibrations achieved strong predictive performance for total NSP [ R 2 = 0.96, ratio of standard error of performance to standard deviation (RPD) = 4.6], cellulose ( R 2 = 0.97, RPD = 5.1), and lignin ( R 2 = 0.90, RPD = 2.8), while the monosaccharides were predicted with robust accuracy ( R 2 typically ≥0.90, RPD ≥ 3.0). Ingredient-specific models for soybean meal showed good performance for the key fiber components, with insoluble NSP achieving R 2 = 0.85 (RPD = 4.5), cellulose with R 2 = 0.94 (RPD = 4.1), and the xylose and glucose calibrations demonstrating strong accuracy ( R 2 ≥ 0.9). The sunflower meal models also performed well, with total NSP achieving R 2 = 0.92 (RPD = 3.3) and lignin with R 2 = 0.90 (RPD = 3.2), while the total xylose and total glucose predictions showed strong accuracy ( R 2 ≥ 0.87, RPD ≥ 3.0). The rapeseed meal models showed strong performance for insoluble NSP ( R 2 = 0.93, RPD = 4.0) and insoluble arabinose ( R 2 = 0.94, RPD = 3.9), while the lignin and cellulose calibrations achieved moderate accuracy ( R 2 = 0.81 and 0.61, respectively). These findings demonstrate the potential of NIRS as a reliable, rapid method for fiber characterization in monogastric feed evaluation. Lignin ; Monosaccharide ; Cellulose ; Monogastric ; Polysaccharide ; Raw material ; Sugar ; Hemicellulose ; Fiber Spectroscopy and Chemometric Analyses ; Food composition and properties ; Ruminant Nutrition and Digestive Physiology
Authors: Kai Li | Qian Wang | Yiqiao Zhou | Zehui Yang | Zuwen Zeng | Yihui An | Lang Bian | Zhenting Zhao | Haijuan Mei | Duoduo Zhang | Weiping Gong | Xudong Qi | Limei Zheng
Source: Microstructures (article, 2026-03-11)
Field: Materials Science — Materials Chemistry

Ultrahigh piezoelectric response in Pb(Ni <sub>1/3</sub> Nb <sub>2/3</sub> )O <sub>3</sub> -PbZrO <sub>3</sub> -PbTiO <sub>3</sub> ceramics To meet the escalating demands for high-performance piezoelectric materials in fields such as modern medical diagnostics, precision manufacturing, etc ., we developed a ternary 0.555Pb(Ni1/3Nb2/3)O3-0.145PbZrO3-0.30PbTiO3 (PNN-PZ-PT) piezoelectric ceramic located at the tricritical point of rhombohedral, tetragonal and pseudocubic phases. This ceramic, with coexistence of multiple ferroelectric phases, demonstrates an ultrahigh piezoelectric coefficient d 33 of 1190 picocoulombs per newton (pC/N) and a large relative dielectric constant ε r of 9900. Analysis of the domain structure reveals irregular maze-like nanodomains with strong local disorder. These nanodomain structures exhibit excellent local piezoelectric response and polarization switching characteristics, thereby enhancing the alignment of polarization vectors during poling and ensuring the high stability after being poled. The tricritical point composition with disordered nanodomains can significantly enhance the contribution of polarization to macroscopic piezoelectric properties, offering a promising approach for developing ceramics with superior piezoelectricity. Piezoelectricity ; Poling ; Polarization (electrochemistry) ; Dielectric ; Piezoelectric coefficient ; Tetragonal crystal system ; Ceramic Ferroelectric and Piezoelectric Materials ; Dielectric materials and actuators ; Chemical and Physical Properties of Materials
Authors: Chuan Yang | Wenge Huang | Shulin Yu
Source:  (article, 2026-03-16)
Field: Materials Science — Materials Chemistry

Design of an STM32 Coaxial Cable Length and Terminal Load Monitoring System Coaxial cable plays a vital role in the wide application of telecommunications, network, and television broadcasting and other fields, with its transmission performance directly affecting signal quality and transmission efficiency. In practical applications, the length of the cable and the terminal load state of the connection often affect the stability of the signal. In order to solve this problem, we used STMicroelectronics STM32F407VET6 (STMicroelectronics, Geneva, Switzerland) as the master controller in this system, and deduced the length of the cable by analyzing the functional relationship between the length of the cable and the open circuit frequency. An open cable is regarded as a capacitor, and any two core wires are regarded as two plates of a flat capacitor. The linear relationship between open frequency and length is used to detect the length of the coaxial cable. The system then determines whether the terminal load is capacitance or resistance based on the detected frequency. If no frequency is detected, then the load is considered resistance. The system detects the resistance value of the resistor through series voltage division. If a frequency is detected, this indicates that the load is capacitance. At this time, the system uses an RC oscillation circuit composed of HGSEMI ICL8038 (Huagao Semiconductor Co., Ltd., Wuxi, China) for testing, and provides the phase shift required by the corresponding signal through the RC network, so as to detect the capacitance value. Finally, we successfully designed a coaxial cable length and terminal load detection system based on STM32F407VET6. Through this system, the user can accurately understand the length of the coaxial cable and the load of the connection terminal, which provides a reliable guarantee for the stability of signal transmission. Coaxial cable ; Capacitance ; Terminal (telecommunication) ; Coaxial ; Resistor ; SIGNAL (programming language) ; Transmission (telecommunications) ; Transmission system ; Oscillation (cell signaling) Advanced Materials and Semiconductor Technologies ; Engineering and Technology Innovations ; Thermal Analysis in Power Transmission
Authors: Candan Şen Elkoca
Source: Düzce Üniversitesi Bilim ve Teknoloji Dergisi (article, 2026-01-21)
Field: Materials Science — Materials Chemistry

The Effect of Surface Properties Created by Industrial Pickling on Paint Adhesion Resistance and Corrosion Performance This study investigated the effects of surface defects, known as acid burns and stop marks, formed during industrial pickling processes on the paint adhesion performance and corrosion resistance of a low-carbon steel sheet. These properties of optimally pickled, heavily pickled, and stop mark-formed surfaces were evaluated comparatively using a post-painting adhesion test (EN ISO 2409:2020) and salt spray (ASTM B117-19) tests. Findings from studies conducted within the industrial pickling range revealed satisfactory paint adhesion (Grade 0) and corrosion resistance (Grade 10) for optimally pickled and heavily pickled surfaces. The stop mark-formed surfaces exhibited excellent paint adhesion, but a slight decrease in corrosion resistance (Grade 9 after 72 hours) was observed. To more accurately assess the impact of these defects, additional tests should be conducted under more challenging and prolonged stop conditions, supported by advanced surface analysis techniques. Pickling ; Corrosion ; Adhesion ; Salt spray test ; Paint adhesion testing ; Salt solution Corrosion Behavior and Inhibition ; Structural Analysis of Composite Materials ; Surface Modification and Superhydrophobicity
Authors: Giovanna Rossi-Márquez | Cristian Aarón Dávalos-Saucedo | Próspero Di Pierro
Source: Coatings (article, 2026-01-28)
Field: Materials Science — Biomaterials

Innovations, Trends, and Future Directions in Edible Films and Coatings The increasing demand for sustainable food systems has sparked interest in sustainable and safe food systems, which has intensified global interest in strategies that can reduce losses, maintain quality, and decrease the environmental footprint of packaging [...] Sustainability ; Food systems ; Ecological footprint ; Carbon footprint ; Food processing ; Sustainable development ; Footprint Nanocomposite Films for Food Packaging ; Consumer Packaging Perceptions and Trends ; Advanced Cellulose Research Studies