jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Federica Brescia | Ioannis Titilas | Simona Cacciapuoti | Luca Ronconi
Source: Molecules (review, 2025-08-29)
Field: Materials Science — Biomaterials

Recent Advances in the Development of Metal-Glycoconjugates for Medicinal Applications Rapidly proliferating tumor cells exhibit elevated demands for nutrients and energy to support their uncontrolled growth, with glucose serving as a key metabolic substrate. Glucose is transported into cells <i>via</i> facilitated diffusion mediated by glucose transporters (GLUTs), after which it undergoes a series of enzymatic reactions to generate energy. To accommodate their heightened metabolic needs, cancer cells frequently overexpress GLUTs, thereby enhancing glucose uptake. Notably, aerobic glycolysis-commonly referred to as the "Warburg effect"-has been identified as the predominant pathway of glucose metabolism within tumor tissues, even in the presence of adequate oxygen levels. Consequently, the conjugation of chemotherapeutic agents, including metallodrugs, to glucose-mimicking substrates holds significant potential for achieving tumor-specific intracellular drug delivery by exploiting the elevated glucose uptake characteristic of cancer cells. Moreover, in recent years, glycosylation of metal scaffolds has been extended to the development of bioactive metallodrugs for applications other than cancer treatment, such as potential tumor imaging, antiviral, antimicrobial, antiparasitic and anti-neurodegenerative agents. Accordingly, major advancements in the design of metal-based glycoconjugates for medicinal applications are here summarized and critically discussed, focusing on related results and discoveries published subsequently to our previous (2015) review article on the topic. Glycoconjugate ; Nanotechnology ; Computational biology ; Computer science ; Chemistry ; Biochemical engineering ; Biology ; Data science ; Engineering ; Bioinformatics ; Materials science Nanoparticle-Based Drug Delivery ; RNA Interference and Gene Delivery ; Chemical Synthesis and Analysis
Authors: Fatemeh Heydari | Ágnes Mária Ilosvai | Noémi Kovács | Domokos Máthé | Ferenc Kristály | Lajos Daróczi | Zoltán Kaleta | Béla Viskolcz | Miklós Nagy | László Vanyorek | László Forgách | Krisztián Szigeti
Source: PLoS ONE (article, 2025-02-06)
Field: Materials Science — Materials Chemistry

Solvothermal synthesis of polyvinyl pyrrolidone encapsulated, amine-functionalized copper ferrite and its use as a magnetic resonance imaging contrast agent Copper ferrite nanoparticles for use as MRI contrast agents were synthesized using two different methods. A novel microwave-assisted (MW) solvothermal method was developed and compared to a conventional 12-hour synthesis (Reflux) as an eco-friendlier approach. This innovative synthesis method successfully produced nanoparticles with enhanced properties compared to traditional ferrite materials. The nanoparticles' morphological and magnetic properties were evaluated and tested in in-vivo MRI studies. The results revealed both similarities and differences between the amine-functionalized copper ferrite nanoparticles. FTIR, XRD, HRTEM, and VSM analyses indicated improved properties in the CuFe2O4-NH2 MW particles, while AFM confirmed successful polymer encapsulation of the nanoparticles. For the CuFe2O4-NH2 MW sample, 76.8 wt% copper ferrite and 23.2 wt% magnetite were detected, with crystallite sizes of 8 ± 2 nm and 13 ± 2 nm, respectively. In the CuFe2O4-NH2 Refl. sample, in addition to these two magnetic phases, larger copper particles (31.6 wt%) were also formed. DLS analysis demonstrated that the CuFe2O4-NH2 MW sample exhibited excellent colloidal stability, maintaining its size distribution in aqueous media for 3 hours without aggregation, unlike the CuFe2O4-NH2 Refl. sample, which showed slight aggregation. The CuFe2O4-NH2 MW sample displayed superparamagnetic behavior (Ms: 15 emu/g, Mr: 0 emu/g, Hc: 0 Oe), while the CuFe2O4-NH2 Refl. sample exhibited ferromagnetic characteristics (Ms: 40 emu/g, Mr: 1.35 emu/g, Hc: 30 Oe). Both samples produced comparable results during in vitro MRI measurements, showing similar T2* relaxation and signal characteristics. Further in vivo studies demonstrated that both samples induced significant hypointense changes. The study provides valuable insights into the synthesis, properties, and potential applications of these materials, emphasizing the importance of eco-friendly methods and the optimization of ferrite-based MRI contrast agents. Materials science ; Superparamagnetism ; Copper ; Nanoparticle ; Ferrite (magnet) ; Crystallite ; Chemical engineering ; Nuclear chemistry ; Nuclear magnetic resonance ; Nanotechnology ; Magnetization ; Composite material ; Chemistry ; Metallurgy Magnetic Properties and Synthesis of Ferrites ; Nanoparticle-Based Drug Delivery ; Multiferroics and related materials
Authors: Junli Wang | Chen Luo | Wentao Wang | Hui Wang | Yao Liu | Jianwei Li | Taihong Yan
Source: Nanomaterials (article, 2025-05-09)
Field: Materials Science — Materials Chemistry

Enhanced Separation of Palladium from Nuclear Wastewater by the Sulfur-Rich Functionalized Covalent Organic Framework The separation of palladium from radioactive waste streams represents a critical aspect of the secure handling and disposal of such hazardous materials. Palladium, in addition to its radioactive nature, holds intrinsic value as a resource. Despite the urgency, prevailing adsorbents fall short in their ability to effectively separate palladium under highly acidic environments. To surmount this challenge, our research has pioneered the development of 1,3,5-tris(4-aminophenyl)benzene-2,5-Bis(methylthio)terephthalaldehyde COF (TAPB-BMTTPA-COF), a novel material distinguished by its remarkable stability and an abundance of sulfur-containing functional groups. Leveraging the pronounced affinity of the soft ligands' nitrogen and sulfur within its molecular architecture, TAPB-BMTTPA-COF demonstrates an exceptional capability for the selective adsorption of palladium. Empirical evidence underscores the material's swift adsorption kinetics, with equilibrium achieved in as little as ten minutes, and its broad tolerance to varying acidity levels ranging from 0.1 to 3 M HNO<sub>3</sub>. Furthermore, TAPB-BMTTPA-COF boasts an impressive adsorption capacity, peaking at 343.6 mg/g, coupled with high selectivity in 13 interfering ions' environment and the ability to be regenerated, making it a sustainable solution. Comprehensive analyses, including Fourier Transform Infrared Spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS), alongside Density Functional Theory (DFT) calculations, have corroborated the pivotal role played by densely packed nitrogen and sulfur active sites within the framework. These sites exhibit a robust affinity for Pd(II), which is the cornerstone of the material's outstanding adsorption efficacy. The outcomes of this research underscore the immense potential of COFs endowed with resilient linkers and precisely engineered functional groups. Such COFs can adeptly capture metal ions with high selectivity, even in the face of severe environmental conditions, thereby paving the way for the more effective and environmentally responsible management of radioactive waste. Palladium ; Adsorption ; X-ray photoelectron spectroscopy ; Sulfur ; Covalent organic framework ; Fourier transform infrared spectroscopy ; Covalent bond ; Materials science ; Chemical engineering ; Chemistry ; Catalysis ; Organic chemistry Covalent Organic Framework Applications ; Metal-Organic Frameworks: Synthesis and Applications ; Radioactive element chemistry and processing
Authors: Jade Cisneros | Ernesto A. Hernández‐Morales | Armando Navarro‐Huerta | Jan Blahut | Erika Bartůňková | Simon J. Teat | Rubén A. Toscano | Martin Dračínský | Braulio Rodríguez‐Molina
Source: Materials Advances (article, 2025-01-01)
Field: Chemistry — Physical and Theoretical Chemistry

Exploring the dynamic behaviour and optical properties of indolocarbazole charge-transfer cocrystals The photothermal conversion properties of two charge-transfer organic cocrystals are linked to their dynamic behavior. Charge (physics) ; Transfer (computing) ; Materials science ; Nanotechnology ; Chemistry ; Computer science ; Physics ; Quantum mechanics Crystallography and molecular interactions ; Nonlinear Optical Materials Research ; Photochromic and Fluorescence Chemistry
Authors: Rikitha S. Fernandes | Neelam Gupta | C. Sanjay | Anamika Anamika | Ambati Himaja | Balaram Ghosh | Biplab Kumar Kuila | Nilanjan Dey
Source: Nanoscale Advances (article, 2025-01-01)
Field: Chemistry — Spectroscopy

Engaging a highly fluorescent conjugated polymer network for probing endogenous hypochlorite in macrophage cells: improved sensitivity <i>via</i> signal amplification We have employed a triazine-based conjugated polymer network (CPN) for the selective detection of hypochlorite in a semi-aqueous environment. CPNs have been widely employed in gas capture, separation, and adsorption, but the fluorescent properties of CPNs possessing extensive π-conjugated systems tend to be unexplored. Herein, we report the photophysical properties of the CPN and investigate its sensing capability towards hypochlorite. Spectroscopic investigations reveal that the CPN forms π-stacked aggregates in aqueous medium, while loose aggregates were observed to be formed in hydrophobic solvents. The fluorogenic CPN demonstrates remarkable selectivity <i>via</i> fluorescence quenching and a blueshift response towards hypochlorite in a semi-aqueous medium, accompanied by a color change under UV light. Such a turn-off fluorescence response, along with the blue shift upon hypochlorite sensing, was attributed to the oxidation of the sulfur atom of the thiophene functionality of the CPN, consequently resulting in suppression of Intramolecular Charge Transfer (ICT) in the corresponding oxidized adduct. The fluorescence intensity of the CPN exhibits a linear response to hypochlorite concentration, achieving a low detection limit of 1.2 nM. Furthermore, the practical applicability was demonstrated by the detection of hypochlorite in water samples and fluorescent test-paper strips. Additionally, the present system is utilized for bio-imaging of endogenous hypochlorite in RAW 264.7 cells. Hypochlorite ; Fluorescence ; Sensitivity (control systems) ; Polymer ; Conjugated system ; SIGNAL (programming language) ; Chemistry ; Biophysics ; Nanotechnology ; Materials science ; Computer science ; Biology ; Electronic engineering ; Organic chemistry ; Engineering ; Optics ; Physics Molecular Sensors and Ion Detection ; Luminescence and Fluorescent Materials ; Sulfur Compounds in Biology
Authors: Laura Coviello | Giorgia Montalbano | Alessandro Piovano | Nagore Izaguirre | Chiara Vitale‐Brovarone | Claudio Gerbaldi | Sonia Fiorilli
Source: Polymers (article, 2025-04-04)
Field: Materials Science — Electronic, Optical and Magnetic Materials

The Impact of Recovered Lignin on Solid-State PEO-Based Electrolyte Produced via Electrospinning: Manufacturing and Characterisation Lithium batteries have gained significant attention due to their high energy density, specific capacity, operating voltage, slow self-discharge rate, good cycle stability, and rapid charging capabilities. However, the use of liquid electrolytes presents several safety hazards. Solid-state polymer electrolytes (SPEs) offer a promising alternative to mitigate these issues. This study focuses on the preparation of an ionically conductive electrospun membrane and its potential application as an SPE. To support a circular approach and reduce the environmental impact, the target polymeric formulation combines poly(ethylene oxide) (PEO) and lignin, sourced from paper industry waste. The formulation is optimised to ensure the dissolution of lithium salts and enhance the membrane integrity. The addition of lignin is crucial to contrast the dendrites' growth and prevent the consequent battery breakdown. The electrospinning process is adjusted to obtain stable, homogeneous nanofibrous membranes, which are characterised using electron scanning microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), and thermal gravimetric analysis (TGA). The membranes' potential as an SPE is assessed by measuring their ionic conductivity (>10<sup>-5</sup> S cm<sup>-1</sup> above 50 °C) and anodic stability (≈4.6 V vs. Li/Li<sup>+</sup>), and by testing their compatibility with lithium metal by reversible cycling in a symmetric Li|Li cell at 55 °C. Electrospinning ; Lignin ; Electrolyte ; Materials science ; Chemical engineering ; Solid-state ; Polymer science ; Polymer ; Composite material ; Organic chemistry ; Chemistry ; Electrode Supercapacitor Materials and Fabrication ; Electrospun Nanofibers in Biomedical Applications ; Advanced Battery Materials and Technologies
Authors: Ben E. Barber | Ellen M. G. Jamieson | Leah White | Charlie T. McTernan
Source: Angewandte Chemie International Edition (review, 2025-07-09)
Field: Materials Science — Biomaterials

Embracing Complexity: Peptides as Tunable Scaffolds in the Construction of Discrete Supramolecular Systems Supramolecular chemistry has advanced rapidly, with scientists using fundamental understanding to generate function from simple building blocks. However, synthetic systems are still in their infancy when compared to biology. The increasing use of peptides in supramolecular structures provides a clear roadmap to more complex function, introducing chiral, information-rich building blocks from a readily available pool. Peptides have historically been incorporated as modular additions to discrete supramolecular architectures to interface with biological systems. More recently, supramolecular chemists have embraced the complexity of secondary and tertiary structures and peptides' intrinsic propensity for folding to enable the formation of supramolecular architectures built from peptides, leveraging their innate properties. We explore the urgent need to embrace complex, chiral, folded building blocks in discrete supramolecular architectures and illustrate how this will provide opportunities for novel functions and applications. Supramolecular chemistry ; Modular design ; Folding (DSP implementation) ; Nanotechnology ; Function (biology) ; Computer science ; Combinatorial chemistry ; Materials science ; Chemistry ; Molecule ; Engineering ; Biology ; Organic chemistry Supramolecular Self-Assembly in Materials ; Chemical Synthesis and Analysis ; Polydiacetylene-based materials and applications
Authors: Prasanth Karikkethu Prabhakaran | Ahmed Kayode Abidoye | Sumit Roy | Venkatesan V. Krishnan
Source: Materials Today Sustainability (article, 2025-05-01)
Field: Materials Science — Materials Chemistry

Layered double hydroxides for sustainable hydrogen production from seawater This work presents investigations on the Oxygen Evolution Reaction (OER) under Alkaline Seawater conditions, using a range of microporous/mesoporous oxide/hydroxide catalysts, notably, Layered Double Hydroxides (LDHs). This study explored a one-step method of coating LDHs onto Ni foams by Hydrothermal Synthesis (directly onto a Ni foam), Dip-coating of Fe, Ni solutions onto the Ni foam and Electrodeposition of LDH onto the Ni foam as well. Hydrothermal Synthesis with direct deposition was considerably stable compared to the other methods, and this research was able to report the electrochemical OER performance on a range of compositions, viz. Ni–Fe in several ratios, and also ternary systems like Ni–Co–Fe. The electrochemical measurements (CV and LSV) showed that Ni–Fe LDHs with Ni: Fe in a 4:1 ratio gave the lowest overpotential (330 mV at 100 mA/cm 2 ) in sea water, which was very much in sync with reported literature on conventional fresh alkaline water – the role played by doping of Ni by Fe, and others like Co, and their oxidation states (examined by XPS) holds the key to enhancing the OER catalytic activity, which is critical for operability in seawater, thus contributing to sustainable and environmentally friendly hydrogen production. This study also demonstrates that Chlorine/Hypochlorite chemistry is largely suppressed under these highly alkaline conditions as predicted by the Pourbaix diagram, although a more extensive degradation study for all cell components is ongoing. Layered double hydroxides ; Seawater ; Hydrogen production ; Production (economics) ; Environmental science ; Hydrogen ; Business ; Chemistry ; Inorganic chemistry ; Geology ; Oceanography ; Economics ; Hydroxide ; Organic chemistry Layered Double Hydroxides Synthesis and Applications ; Advanced Photocatalysis Techniques ; Industrial Gas Emission Control
Authors: Liqing Shi | Tianyuan Xin | Peng Cheng | Zhengying Wu | Shuangxi Liu | Kai Yu | Lanlan Lou
Source: Smart Materials and Devices (review, 2025-01-01)
Field: Chemistry — Inorganic Chemistry

UiO series of MOFs and their composites for photocatalytic CO2 reduction: A review Photocatalytic reduction of CO2 to produce valuable fuels or chemicals is a promising CO2 utilization technology, which is of great significance for carbon emission reduction. The unique features of the UiO series of metal-organic frameworks (MOFs), such as the excellent water and chemical stability, notable structural tunability, broad and adjustable light-harvesting capacity, strong electron-hole separation ability, and high porosity and specific surface area, make them a class of photocatalysts with great potential for the CO2 reduction reaction (CO2RR). Significant progress has been made in the development of efficient UiO-based photocatalysts for CO2RR. This paper provides a summary of recent research advances in UiO-MOFs for photocatalytic CO2RR. The characteristics, synthesis methods, and modifications of UiO-based materials, along with their photocatalytic performance, are described. Various modification strategies for UiO-MOFs, including band-gap engineering, defect engineering, introduction of metal species, and construction of composite materials, are summarized and discussed. The challenges facing UiO-MOFs in photocatalytic CO2RR and potential future development directions are also presented. This review is intended to provide insights into CO2 photoreduction using UiO-based materials and to encourage further research and development in this promising field. Photocatalysis ; Series (stratigraphy) ; Reduction (mathematics) ; Composite material ; Materials science ; Mathematics ; Chemistry ; Catalysis ; Geology Metal-Organic Frameworks: Synthesis and Applications ; Advanced Photocatalysis Techniques ; Gas Sensing Nanomaterials and Sensors
Authors: Tetsuhiro Nemoto | Shingo Harada | Takahito Kuribara | Shinji Harada
Source: Organic & Biomolecular Chemistry (review, 2025-01-01)
Field: Chemistry — Organic Chemistry

Recent advances in the synthesis of 3,4-fused tricyclic indoles The 3,4-fused tricyclic indole framework is a key structural motif in numerous bioactive natural products and pharmaceuticals, thus, it has drawn much attention in synthetic organic chemistry. Synthetic organic chemists have expended substantial effort in developing efficient methods for constructing this privileged molecular framework. In this review, we highlight the advances made in this area, particularly since 2018. Tricyclic ; Indole test ; Chemistry ; Combinatorial chemistry ; Organic chemistry Synthesis of Indole Derivatives ; Bioactive Compounds and Antitumor Agents ; Synthesis and Reactions of Organic Compounds
Authors: Seul‐Yi Lee | Nicole Sim | Jagadis Gautam | S. Prabhakar | Young‐Teck Kim | Soojin Park | Roop L. Mahajan | Jihoon Lee
Source: Advanced Composites and Hybrid Materials (article, 2025-04-01)
Field: Materials Science — Materials Chemistry

Simultaneous synthesis of multiple functional carbon emitters and their biosensing applications This study demonstrates that the properties of nitrogen-doped carbon dots (N-CDs), synthesized via one-step microwave-assisted pyrolysis using different molar ratios of ammonium citrate dibasic (ACD) and ethylenediamine (EDA), are influenced by both their functional groups and particle size. Eight different sizes of N-CD, separated through multiple filtrations, exhibit bright chemiluminescence and fluorescence at various wavelengths. Notably, N-CDs smaller than 10 nm, known as carbon dots, demonstrate superior quantum efficiency. The functional groups on these N-CDs, with varying carbon, nitrogen, and oxygen ratios, can be selectively leveraged to create highly sensitive chemiluminescent or fluorescent biosensors and develop cell imaging techniques. For instance, N-CDs with a molecular weight cutoff (MWCO) of 30–50 kDa, synthesized using a 2:1 ACD to EDA ratio, were employed to detect trace copper ions selectively. The copper-bound N-CD complex mimicked horseradish peroxidase (HRP)-like activity, enabling rapid detection of glucose. Carbon dots labeled with carcinoembryonic antigen (CEA) antibodies also served as bright chemiluminescent emitters in a sensitive sandwich immunoassay for cancer detection. Overall, the diverse size range and functionalization of N-CDs offer a robust platform for developing next-generation sensor technologies. Biosensor ; Carbon fibers ; Nanotechnology ; Environmental science ; Computer science ; Biochemical engineering ; Materials science ; Engineering Carbon and Quantum Dots Applications ; Advanced biosensing and bioanalysis techniques ; Nanocluster Synthesis and Applications
Authors: Jun Guo | Jing Shi | Lisheng Xu | Xingtao Zhang | Fangkai Han | Minwei Xu
Source: Gels (article, 2025-07-28)
Field: Materials Science — Biomaterials

Study on Preparation and Properties of Super Absorbent Gels of Homogenous Cotton Straw-Acrylic Acid-Acrylamide by Graft Copolymerization To rationally utilize and develop agricultural waste products, this research involved the synthesis of degradable high water-absorbing resin through the graft copolymerization of cotton straw (CS) with monomers. Among them, acrylic acid (AA) and acrylamide (Am) are used as grafting copolymer monomers, cellulose in the straw serves as the network framework, and MBA acts as the crosslinking agent. <sup>60</sup>Co gamma rays as initiators. Different concentrations of alkaline solution were used to dissolve the cellulose in the straw. Single-factor and orthogonal experiments were conducted to optimize the experimental conditions. various analytical methods such as thermogravimetric analysis (TG), X-ray crystallography (XRD), infrared spectroscopy (IR), and scanning electron microscopy (SEM) were employed to characterize the structure and properties of the product. <sup>60</sup>Co gamma rays as initiators, can reduce the pollution caused by chemical initiators and lower energy consumption. Through this research, agricultural waste can be effectively utilized, reducing environmental pollution, lowering industrial energy consumption, and synthesizing degradable and environmentally friendly high-absorbent resins. The product can be applied to agricultural water retention agent, fertilizer controlled release agent and other aspects. Copolymer ; Acrylic acid ; Monomer ; Cellulose ; Acrylamide ; Straw ; Materials science ; Thermogravimetric analysis ; Grafting ; Chemical engineering ; Polymer ; Polymer chemistry ; Chemistry ; Organic chemistry ; Composite material Advanced Cellulose Research Studies ; Hydrogels: synthesis, properties, applications ; Electrospun Nanofibers in Biomedical Applications