jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Erez Cohen | Elena Poverenov
Source: Chemistry - A European Journal (review, 2022-09-08)
Field: Materials Science — Biomaterials

Hydrophilic Chitosan Derivatives: Synthesis and Applications Polymer alternatives sourced from nature have attracted increasing attention for applications in medicine, cosmetics, agriculture, food, water purification, and more. Among them, chitosan is the most versatile due to its full biodegradability, exceptional biocompatibility, multipurpose bioactivity, and low toxicity. Although remarkable progress has been made in its synthetic modification by using C3/C6 secondary/primary hydroxy (-OH) and the C2 amino (-NH<sub>2</sub> ) active sites, its solubility under physiological conditions remains limited and has hampered larger-scale adoption. This review summarizes different synthetic methods that increase chitosan's hydrophilicity and water solubility by using covalent modifications, namely amino acid addition, quaternary ammonium formation, phosphorylation, and carboxymethylation. We also review several applications for each type of substitution in fields such as cosmetics, medicine, agriculture, and water purification, and provide an outlook and perspective for future modifications and implementations. Chitosan ; Cosmetics ; Biocompatibility ; Solubility ; Chemistry ; Combinatorial chemistry ; Organic chemistry ; Ammonium ; Biocompatible material ; Nanotechnology ; Biotechnology ; Materials science ; Engineering ; Biology ; Biomedical engineering Nanocomposite Films for Food Packaging ; Electrospun Nanofibers in Biomedical Applications ; Polymer Surface Interaction Studies
Authors: Shameer M. Kondengadan | Shubham Bansal | Ce Yang | Dong-Ning Liu | Zach Fultz | Binghe Wang
Source: Acta Pharmaceutica Sinica B (review, 2022-10-21)
Field: Chemistry — Organic Chemistry

Click chemistry and drug delivery: A bird's-eye view Click chemistry has been proven to be very useful in drug delivery. Due to the availability of a large number of click reactions with a various characteristics, selection of appropriate chemistry for a given application is often not a trivial task. This review is written for pharmaceutical researchers who are interested in click chemistry applications and yet may not be click chemistry experts. For this, the review gives an overview of available click reactions organized by application types. Further, the general understanding of click reactions being fast and high yielding sometimes overshadows the need to analyze reaction kinetics in assessing suitability of a given reaction for certain applications. For this, we highlight the need to analyze the relationship among reaction kinetics, concentration effects, and reaction time scales, knowing that lack of such analysis could easily lead to failures. Further, possible issues such as chemical stability with various click reagents are also discussed to aid experimental designs. Recent examples and extensive references are also provided to aid in-depth understanding of technical details. We hope this review will help those interested in using click chemistry in drug delivery to select the appropriate reactions/reagents and minimize the number of pitfalls. Click chemistry ; Computer science ; Chemistry ; Nanotechnology ; Biochemical engineering ; Combinatorial chemistry ; Materials science ; Engineering Click Chemistry and Applications ; Advanced biosensing and bioanalysis techniques ; RNA Interference and Gene Delivery
Authors: Emma van Groesen | Paolo Innocenti | Nathaniel I. Martin
Source: ACS Infectious Diseases (review, 2022-07-27)
Field: Chemistry — Organic Chemistry

Recent Advances in the Development of Semisynthetic Glycopeptide Antibiotics: 2014–2022 The accelerated appearance of drug-resistant bacteria poses an ever-growing threat to modern medicine's capacity to fight infectious diseases. Gram-positive species such as methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and <i>Streptococcus pneumoniae</i> continue to contribute significantly to the global burden of antimicrobial resistance. For decades, the treatment of serious Gram-positive infections relied upon the glycopeptide family of antibiotics, typified by vancomycin, as a last line of defense. With the emergence of vancomycin resistance, the semisynthetic glycopeptides telavancin, dalbavancin, and oritavancin were developed. The clinical use of these compounds is somewhat limited due to toxicity concerns and their unusual pharmacokinetics, highlighting the importance of developing next-generation semisynthetic glycopeptides with enhanced antibacterial activities and improved safety profiles. This Review provides an updated overview of recent advancements made in the development of novel semisynthetic glycopeptides, spanning the period from 2014 to today. A wide range of approaches are covered, encompassing innovative strategies that have delivered semisynthetic glycopeptides with potent activities against Gram-positive bacteria, including drug-resistant strains. We also address recent efforts aimed at developing targeted therapies and advances made in extending the activity of the glycopeptides toward Gram-negative organisms. Glycopeptide ; Dalbavancin ; Vancomycin ; Antibiotics ; Streptococcus pneumoniae ; Linezolid ; Antimicrobial ; Glycopeptide antibiotic ; Microbiology ; Antibiotic resistance ; Biology ; Medicine ; Staphylococcus aureus ; Bacteria Carbohydrate Chemistry and Synthesis ; Antimicrobial Peptides and Activities ; Microbial Natural Products and Biosynthesis
Authors: Zhiwei Lu | Suru Chen | Maoting Chen | Hao Ma | Tanke Wang | Tao Liu | Jiajian Yin | Mengmeng Sun | Wu Chun | Gehong Su | Xianxiang Dai | Xianxiang Wang | Yanying Wang | Huadong Yin | Xinguang Zhou | Yizhong Shen | Hanbing Rao
Source: Chemical Engineering Journal (article, 2022-11-21)
Field: Materials Science — Materials Chemistry

Trichromatic ratiometric fluorescent sensor based on machine learning and smartphone for visual and portable monitoring of tetracycline antibiotics Tetracycline ; Fluorescence ; Computer science ; Human–computer interaction ; Artificial intelligence ; Antibiotics ; Chemistry ; Computer vision ; Optics ; Biochemistry ; Physics Carbon and Quantum Dots Applications ; Nanocluster Synthesis and Applications ; Advanced Nanomaterials in Catalysis
Authors: Shawana Tabassum | SK Nayemuzzaman | Manish Kala | Akhilesh Kumar Mishra | Satyendra K. Mishra
Source: Sensors (review, 2022-09-13)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Metasurfaces for Sensing Applications: Gas, Bio and Chemical Performance of photonic devices critically depends upon their efficiency on controlling the flow of light therein. In the recent past, the implementation of plasmonics, two-dimensional (2D) materials and metamaterials for enhanced light-matter interaction (through concepts such as sub-wavelength light confinement and dynamic wavefront shape manipulation) led to diverse applications belonging to spectroscopy, imaging and optical sensing etc. While 2D materials such as graphene, MoS<sub>2</sub> etc., are still being explored in optical sensing in last few years, the application of plasmonics and metamaterials is limited owing to the involvement of noble metals having a constant electron density. The capability of competently controlling the electron density of noble metals is very limited. Further, due to absorption characteristics of metals, the plasmonic and metamaterial devices suffer from large optical loss. Hence, the photonic devices (sensors, in particular) require that an efficient dynamic control of light at nanoscale through field (electric or optical) variation using substitute low-loss materials. One such option may be plasmonic metasurfaces. Metasurfaces are arrays of optical antenna-like anisotropic structures (sub-wavelength size), which are designated to control the amplitude and phase of reflected, scattered and transmitted components of incident light radiation. The present review put forth recent development on metamaterial and metastructure-based various sensors. Plasmon ; Metamaterial ; Optoelectronics ; Materials science ; Photonics ; Photonic metamaterial ; Optics ; Wavefront ; Wavelength ; Nanotechnology ; Physics Metamaterials and Metasurfaces Applications ; Plasmonic and Surface Plasmon Research ; Optical Wireless Communication Technologies
Authors: Ying Gu | Yonghui Li | Dabing Ren | Liping Sun | Yongliang Zhuang | Lunzhao Yi | Shuo Wang
Source: Food Frontiers (article, 2022-03-07)
Field: Chemistry — Electrochemistry

Recent advances in nanomaterial‐assisted electrochemical sensors for food safety analysis Abstract Food safety as a public health issue has aroused worldwide concern. Food safety risks caused by the existence of food safety hazards in food may occur in all stages of the food supply chain. Thus, great emphasis is placed on sensitive, selective, and convenient analytical methods of various food safety hazards in food. At present, nanomaterials are at the forefront of various electrochemical sensing applications. Given their unique physical, chemical, and biological characteristics, nanomaterials are considered perfect candidates for the design of electrode surface to construct electrochemical sensors with excellent analytical performance. With the assistance of nanomaterials, electrochemical sensors are a potential alternative to conventional methods of food safety analysis. This review focuses on current research achievements of nanomaterial‐assisted electrochemical sensors for food safety analysis reported in recent 5 years. It highlights the different detection mechanisms for analytes, flexible sensing strategies based on nanomaterials, and portable miniaturized electrochemical devices. Finally, the challenges and limitations in the design of electrochemical sensors for food safety analysis are also discussed. Food safety ; Nanomaterials ; Nanotechnology ; Risk analysis (engineering) ; Food packaging ; Computer science ; Biochemical engineering ; Business ; Materials science ; Engineering ; Chemistry ; Food science Electrochemical Analysis and Applications ; Advanced biosensing and bioanalysis techniques ; Electrochemical sensors and biosensors
Authors: Niusha Ahadi | Sima Askari | Amir Fouladitajar | Iman Akbari
Source: Scientific Reports (article, 2022-02-16)
Field: Chemistry — Inorganic Chemistry

Facile synthesis of hierarchically structured MIL-53(Al) with superior properties using an environmentally-friendly ultrasonic method for separating lead ions from aqueous solutions The present study aims at investigating sonochemically synthesized MIL-53(Al) and its applications in adsorption lead ions from aqueous solution. XRD, FESEM, BET, and FTIR analyses were employed to identify and characterize MIL-53(Al). The ultrasonic-assisted synthesis procedure results in reducing the synthesis time to 24 h; however, the conventional synthesis of MIL-53(Al) takes 3 days. Applying ultrasonic waves also leads to increase of the specific surface area up to 50% more than that of synthesized by the conventional method, as well as creating the hierarchical MIL-53(Al) structure which reduces the mass transfer limitation of ions into internal micropores. The optimum conditions for removing lead ions are pH of 6, Pb<sup>+2</sup> ion concentration of 20 mg/L, contact time of 60 min, adsorbent dose of 0.04 g, and temperature of 318 K with the removal efficiency of 97.63%. The experimental adsorption equilibrium and kinetic data fit the Langmuir isotherm and pseudo-second-order kinetic models, respectively. Moreover, the usage of sonochemically synthesized MIL-53(Al), for the first time as an adsorbent in heavy metal removal points to the great potential of this new environmentally-friendly adsorbent in removing lead ions from aqueous solutions. Aqueous solution ; Adsorption ; Environmentally friendly ; Ion ; Langmuir adsorption model ; Materials science ; Fourier transform infrared spectroscopy ; Chemical engineering ; Metal ions in aqueous solution ; Langmuir ; Ultrasonic sensor ; Kinetic energy ; Chemistry ; Physical chemistry ; Organic chemistry ; Physics Metal-Organic Frameworks: Synthesis and Applications ; Chemical Synthesis and Characterization ; Adsorption and biosorption for pollutant removal
Authors: Yihui He | Ido Hadar | Michael C. De Siena | Vladislav V. Klepov | Lei Pan | Duck Young Chung | Mercouri G. Kanatzidis
Source: Advanced Functional Materials (article, 2022-03-09)
Field: Materials Science — Materials Chemistry

Sensitivity and Detection Limit of Spectroscopic‐Grade Perovskite CsPbBr<sub>3</sub> Crystal for Hard X‐Ray Detection Abstract Spectroscopic‐grade single crystal detectors can register the energies of individual X‐ray interactions enabling photon‐counting systems with superior resolution over traditional photoconductive X‐ray detection systems. Current technical challenges have limited the preparation of perovskite semiconductors for energy‐discrimination X‐ray photon‐counting detection. Here, this work reports the deployment of a spectroscopic‐grade CsPbBr 3 Schottky detector under reverse bias for continuum hard X‐ray detection in both the photocurrent and spectroscopic schemes. High surface barriers of ≈ 1 eV are formed by depositing solid bismuth and gold contacts. The spectroscopic response under a hard X‐ray source is assessed in resolving the characteristic X‐ray peak. The methodology in enhancing X‐ray sensitivity by controlling the X‐ray energies and flux, and voltage, is described. The X‐ray sensitivity varies between a few tens to over 8000 μC Gy air −1 cm −2 . The detectable dose rate of the CsPbBr 3 detectors is as low as 0.02 nGy air s −1 in the energy discrimination configuration. Finally, the unbiased CsPbBr 3 device forms a spontaneous contact potential difference of about 0.7 V enabling high quality of the CsPbBr 3 single crystals to operate in “passive” self‐powered X‐ray detection mode and the X‐ray sensitivity is estimated as 14 μC Gy air −1 cm −2 . The great potential of spectroscopic‐grade CsPbBr 3 devices for X‐ray photon‐counting systems is anticipated in this work. X-ray detector ; Detector ; Materials science ; Optoelectronics ; Sensitivity (control systems) ; Photoelectric effect ; Photon ; Photon counting ; X-ray ; Photocurrent ; Optics ; Semiconductor ; Physics ; Electronic engineering Luminescence Properties of Advanced Materials ; Perovskite Materials and Applications ; Advanced X-ray and CT Imaging
Authors: О. М. Цивилева | Oleg V. Koftin | Nina V. Evseeva
Source: Antibiotics (review, 2022-08-26)
Field: Chemistry — Organic Chemistry

Coumarins as Fungal Metabolites with Potential Medicinal Properties Coumarins are a structurally varied set of 2<i>H</i>-chromen-2-one compounds categorized also as members of the benzopyrone group of secondary metabolites. Coumarin derivatives attract interest owing to their wide practical application and the unique reactivity of fused benzene and pyrone ring systems in molecular structure. Coumarins have their own specific fingerprints as antiviral, antimicrobial, antioxidant, anti-inflammatory, antiadipogenic, cytotoxic, apoptosis, antitumor, antitubercular, and cytotoxicity agents. Natural products have played an essential role in filling the pharmaceutical pipeline for thousands of years. Biological effects of natural coumarins have laid the basis of low-toxic and highly effective drugs. Presently, more than 1300 coumarins have been identified in plants, bacteria, and fungi. Fungi as cultivated microbes have provided many of the nature-inspired syntheses of chemically diverse drugs. Endophytic fungi bioactivities attract interest, with applications in fields as diverse as cancer and neuronal injury or degeneration, microbial and parasitic infections, and others. Fungal mycelia produce several classes of bioactive molecules, including a wide group of coumarins. Of promise are further studies of conditions and products of the natural and synthetic coumarins' biotransformation by the fungal cultures, aimed at solving the urgent problem of searching for materials for biomedical engineering. The present review evaluates the fungal coumarins, their structure-related peculiarities, and their future therapeutic potential. Special emphasis has been placed on the coumarins successfully bioprospected from fungi, whereas an industry demand for the same coumarins earlier found in plants has faced hurdles. Considerable attention has also been paid to some aspects of the molecular mechanisms underlying the coumarins' biological activity. The compounds are selected and grouped according to their cytotoxic, anticancer, antibacterial, antifungal, and miscellaneous effects. Antimicrobial ; Natural product ; Coumarin ; Mycelium ; Biology ; Biotransformation ; Chemistry ; Organic chemistry ; Biochemistry ; Botany Chemical synthesis and alkaloids ; Microbial Natural Products and Biosynthesis ; Fungal Biology and Applications
Authors: Shalu Yadav | Mohd. Abubakar Sadique | Ajeet Kaushik | Pushpesh Ranjan | Raju Khan | Avanish Kumar Srivastava
Source: Journal of Materials Chemistry B (review, 2022-01-01)
Field: Materials Science — Materials Chemistry

Borophene as an emerging 2D flatland for biomedical applications: current challenges and future prospects Recently, two-dimensional (2D)-borophene has emerged as a remarkable translational nanomaterial substituting its predecessors in the field of biomedical sensors, diagnostic tools, high-performance healthcare devices, super-capacitors, and energy storage devices. Borophene justifies its demand due to high-performance and controlled optical, electrical, mechanical, thermal, and magnetic properties as compared with other 2D-nanomaterials. However, continuous efforts are being made to translate theoretical and experimental knowledge into pragmatic platforms. To cover the associated knowledge gap, this review explores the computational and experimental chemistry needed to optimize borophene with desired properties. High electrical conductivity due to destabilization of the highest occupied molecular orbital (HOMO), nano-engineering at the monolayer level, chemistry-oriented biocompatibility, and photo-induced features project borophene for biosensing, bioimaging, cancer treatment, and theragnostic applications. Besides, the polymorphs of borophene have been useful to develop specific bonding for DNA sequencing and high-performance medical equipment. In this review, an overall critical and careful discussion of systematic advancements in borophene-based futuristic biomedical applications including artificial intelligence (AI), Internet-of-Things (IoT), and Internet-of-Medical Things (IoMT) assisted smart devices in healthcare to develop high-performance biomedical systems along with challenges and prospects is extensively addressed. Consequently, this review will serve as a key supportive platform as it explores borophene for next-generation biomedical applications. Finally, we have proposed the potential use of borophene in healthcare management strategies. Borophene ; Nanotechnology ; Current (fluid) ; Materials science ; Engineering ; Graphene ; Electrical engineering MXene and MAX Phase Materials ; 2D Materials and Applications ; Advanced biosensing and bioanalysis techniques
Authors: Ali Taghizadeh | Mohsen Taghizadeh | Mohsen Khodadadi Yazdi | Payam Zarrintaj | Joshua D. Ramsey | Farzad Seidi | Florian J. Stadler | Haeshin Lee | Mohammad Reza Saeb | Masoud Mozafari
Source: Bioengineering & Translational Medicine (review, 2022-07-26)
Field: Materials Science — Surfaces, Coatings and Films

Mussel‐inspired biomaterials: From chemistry to clinic After several billions of years, nature still makes decisions on its own to identify, develop, and direct the most effective material for phenomena/challenges faced. Likewise, and inspired by the nature, we learned how to take steps in developing new technologies and materials innovations. Wet and strong adhesion by <i>Mytilidae</i> mussels (among which <i>Mytilus edulis</i>-blue mussel and <i>Mytilus californianus</i>-California mussel are the most well-known species) has been an inspiration in developing advanced adhesives for the moist condition. The wet adhesion phenomenon is significant in designing tissue adhesives and surgical sealants. However, a deep understanding of engaged chemical moieties, microenvironmental conditions of secreted proteins, and other contributing mechanisms for outstanding wet adhesion mussels are essential for the optimal design of wet glues. In this review, all aspects of wet adhesion of Mytilidae mussels, as well as different strategies needed for designing and fabricating wet adhesives are discussed from a chemistry point of view. Developed muscle-inspired chemistry is a versatile technique when designing not only wet adhesive, but also, in several more applications, especially in the bioengineering area. The applications of muscle-inspired biomaterials in various medical applications are summarized for future developments in the field. Mytilidae ; Mytilus ; Mussel ; Nanotechnology ; Adhesion ; Biochemical engineering ; Polymer science ; Chemistry ; Materials science ; Engineering ; Biology ; Ecology ; Bivalvia ; Composite material Polymer Surface Interaction Studies ; Adhesion, Friction, and Surface Interactions ; Knee injuries and reconstruction techniques
Authors: Rachel Miller | Lloyd M. Smith
Source: The Analyst (review, 2022-11-14)
Field: Chemistry — Spectroscopy

Overview and considerations in bottom-up proteomics Proteins are the key biological actors within cells, driving many biological processes integral to both healthy and diseased states. Understanding the depth of complexity represented within the proteome is crucial to our scientific understanding of cellular biology and to provide disease specific insights for clinical applications. Mass spectrometry-based proteomics is the premier method for proteome analysis, with the ability to both identify and quantify proteins. Although proteomics continues to grow as a robust field of bioanalytical chemistry, advances are still necessary to enable a more comprehensive view of the proteome. In this review, we provide a broad overview of mass spectrometry-based proteomics in general, and highlight four developing areas of bottom-up proteomics: (1) protein inference, (2) alternative proteases, (3) sample-specific databases and (4) post-translational modification discovery. Proteomics ; Computer science ; Data science ; Computational biology ; Biology Advanced Proteomics Techniques and Applications ; Ubiquitin and proteasome pathways ; Glycosylation and Glycoproteins Research
Authors: Nurina Adriana Abdul Razak | Nur Hidayati Othman | Muhammad Shafiq Mat Shayuti | Aidah Jumahat | Napisah Sapiai | Woei Jye Lau
Source: Journal of environmental chemical engineering (review, 2022-02-03)
Field: Materials Science — Materials Chemistry

Agricultural and industrial waste-derived mesoporous silica nanoparticles: A review on chemical synthesis route Mesoporous silica ; Agricultural waste ; Materials science ; Nanotechnology ; Waste management ; Mesoporous material ; Environmental science ; Process engineering ; Catalysis ; Engineering ; Chemistry ; Organic chemistry Mesoporous Materials and Catalysis ; Zeolite Catalysis and Synthesis ; Layered Double Hydroxides Synthesis and Applications