jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Subrata Biswas | Md. Maruf Shaikh | Sukanto Baul | Rasel Mia | Rajib Saha | Sohaib Ali Sajid | Madiha Zainab | Muhammad Saqib | Md. Al-Amin | Muhammad Shoaib Ismail
Source: Scholars Journal of Engineering and Technology (article, 2025-08-19)
Field: Materials Science — Biomaterials

Engineered Nanomaterials and Hybrid Molecular Systems for Therapeutic Applications and Sustainable Energy Storage Engineered nanomaterials and hybrid molecular systems have emerged as transformative platforms uniting advanced therapeutics with sustainable energy storage technologies. In biomedical applications, functional nanostructures—ranging from polymer–inorganic hybrids to bioinspired core–shell architectures—enable targeted drug delivery, tunable release kinetics, improved biocompatibility, and real-time bioimaging. Hybrid molecular systems such as lipid–polymer conjugates, peptide-functionalized metal–organic frameworks, and graphene–biopolymer composites achieve multifunctionality critical for navigating complex pathological microenvironments. Recent therapeutic breakthroughs report particle size control within 50–150 nm for optimal tumor accumulation, and drug encapsulation efficiencies exceeding 90%, enabling precise and efficient treatment modalities. In sustainable energy storage, nanostructured hybrids incorporating conductive polymers, carbon allotropes, and transition metal compounds demonstrate high specific capacitance (&gt;400 F g⁻¹), rapid charge–discharge rates, and extended cycle stability (&gt;10,000 cycles). Dual-function nanoplatforms now integrate photothermal therapy with photovoltaic energy harvesting, while bio-derived hybrids offer concurrent therapeutic delivery and supercapacitor performance. Notably, bio-inspired design principles enable cost-effective synthesis and resource-efficient scalability, aligning with circular economy goals. This review critically examines design strategies, synthesis methodologies, and performance metrics governing these multifunctional materials, with emphasis on their cross-domain adaptability. The synergistic integration of therapeutic and energy storage functionalities is anticipated to catalyze a new class of high-performance, resource-conscious technologies, bridging healthcare innovation and sustainable energy solutions. Energy storage ; Nanotechnology ; Nanomaterials ; Materials science ; Physics Supramolecular Self-Assembly in Materials ; Graphene and Nanomaterials Applications ; Fullerene Chemistry and Applications
Authors: Daria Armani
Source: RSC Sustainability (article, 2025-01-01)
Field: Chemistry — Organic Chemistry

Synthetic routes and fields of application of isohexides: comprehensive perspective of relevant industrial compounds This review represents a first investigation into the possible uses of isohexide-based compounds by analyzing the positive and negative aspects of their exploitation as ubiquitous alternatives to current oil-based intermediates. Perspective (graphical) ; Field (mathematics) ; Computer science ; Engineering ; Data science ; Artificial intelligence ; Mathematics Chemical Synthesis and Reactions
Authors: Muhammad Waqar | Shawana Ambreen | Nayab Qayyum | Sudha Rani Sadras | Laiba Mehmood | Faiza Kausar | Fahad Ghazanfar
Source: Journal of medical & health sciences review. (article, 2025-11-09)
Field: Materials Science — Biomaterials

&lt;b&gt;REVIEW ON THE ROLE OF NANOPARTICLES IN OVERCOMING DRUG RESISTANCE IN CANCER: MECHANISTIC AND THERAPEUTIC PERSPECTIVES&lt;/b&gt; Nanoparticles have emerged as a transformative platform in cancer therapeutics due to their unique physicochemical properties and ability to overcome the limitations of conventional chemotherapy. This review offers a thorough explanation of nanoparticles, their categorization, and their molecular functions in the fight against cancer treatment resistance. Metal-based, ceramic, and carbon-based nanostructures are examples of the organic and inorganic forms of nanoparticles, each of which offers unique physicochemical properties for targeted drug delivery. While inorganic and metallic nanoparticles offer better stability, controlled release, and imaging potential, organic nanoparticles like liposomes and polymeric carriers improve biocompatibility and drug solubility. Targeted drug delivery, improved permeability and retention effects, and regulated intracellular release that reduces systemic toxicity are the processes of nanoparticle-mediated cancer therapy. Both intrinsic and extrinsic mechanisms, such as altered drug efflux, apoptotic inhibition, tumor hypoxia, and enzymatic degradation of anticancer medicines, can lead to drug resistance in cancer. Collectively, this review highlights the pivotal role of nanotechnology in redefining strategies to overcome cancer drug resistance and enhance treatment outcomes. Drug ; Biocompatibility ; Drug delivery ; Nanoparticle ; Drug carrier ; Nanomedicine ; Drug resistance ; Cancer Nanoparticle-Based Drug Delivery ; Cancer Research and Treatment ; Nanoplatforms for cancer theranostics
Authors: Juan Camilo Arango‐Daza | Mathieu Onillon | Leonie Nork | Kunpot Mopoung | Yuttapoom Puttisong | Miguel A. Rivero‐Crespo
Source: ChemRxiv (preprint, 2025-07-14)
Field: Chemistry — Inorganic Chemistry

Metal-Organic Framework/Organocatalyst Combinations as Powerful Multicatalytic Systems for Aerobic Oxidations Aerobic oxidation using molecular oxygen as terminal oxidant represents a sustainable route to access valuable organic compounds. However, achieving high selectivity in such transformations remains challenging. Here, we report an easily tunable biomimetic multicatalytic system combining robust Metal-Organic Frameworks (MOFs) and simple, commercially available (hydro)quinone-type co-catalysts, which mimics the cooperative action of enzyme/coenzyme pairs in a confined environment. A Zr-MOF-808/1,8-Dihydroxynaphthalene semiheterogeneous system enables the aerobic oxidation of anilines to azoxybenzenes, products that are typically elusive under aerobic conditions, with excellent yields and selectivity. Ligand-to-metal charge-transfer (LMCT) triggers the formation of active oxidation sites in the MOF/(hydro)quinone interface, able to generate reactive oxygen species from O2 under mild conditions without the need for light or other external stimuli. The generality of this novel multicatalytic approach is demonstrated by expanding it to different reactions and catalytic systems. In particular, the aerobic oxidation of thiols to disulfides is achieved by changing the organic co-catalyst, whereas benzylamines are aerobically oxidized to their corresponding coupled products by employing a Ti-based MOF (Ti-MIL-125). This work highlights the untapped potential of MOF/organocatalyst combinations to drive challenging reactions under environmentally benign conditions. Chemistry ; Organic synthesis ; Metal-organic framework ; Organic chemistry ; Combinatorial chemistry ; Catalysis Metal-Organic Frameworks: Synthesis and Applications ; Chemical Synthesis and Reactions ; Catalysis and Oxidation Reactions
Authors: Ganesh Hiralal Pendhare
Source: International Journal of Research & Technology (article, 2025-12-18)
Field: Chemistry — Organic Chemistry

Green Synthesis of Bioactive Organic Compounds: Recent Advances and Future Prospects Green synthesis has emerged as an important approach in modern organic chemistry, especially for the preparation of bioactive organic compounds with pharmaceutical, agricultural, and industrial applications. Conventional synthetic methods often involve toxic solvents, hazardous reagents, high energy consumption, and waste generation, posing risks to both human health and the environment. To overcome these challenges, green chemistry promotes sustainable strategies based on safer solvents, renewable resources, catalytic processes, atom economy, and energy-efficient techniques. This paper examines the principles, methods, and recent advances in the green synthesis of bioactive organic compounds. It focuses on important classes such as heterocyclic compounds, flavonoids, alkaloids, coumarins, quinolines, and pyrazoles, which exhibit significant biological activities including antimicrobial, antioxidant, anti-inflammatory, anticancer, and antiviral properties. The study highlights modern green techniques such as microwave-assisted synthesis, ultrasound-assisted reactions, solvent-free methods, biocatalysis, deep eutectic solvents, and multicomponent reactions. Furthermore, the paper discusses the role of green synthesis in drug discovery and sustainable industrial processes. Although significant progress has been achieved, challenges such as scalability, catalyst recovery, and economic feasibility remain. Overall, green synthesis offers an efficient and environmentally responsible pathway for the future development of bioactive organic molecules. Hazardous waste ; Organic synthesis ; Green chemistry ; Renewable energy ; Human health ; SAFER ; Sustainable production Multicomponent Synthesis of Heterocycles ; Microwave-Assisted Synthesis and Applications ; Chemistry and Chemical Engineering
Source:  (article, 2025-01-01)
Field: Materials Science — Materials Chemistry

Mechanism and Application of Metal Nanoparticles as Antimicrobial Agents Antimicrobial resistance (AMR) is one of the major concerns worldwide that has emerged as the leading source of mortality and morbidity due to bacterial infection because of their resistance to antibiotics.Overuse of antibiotics has led to the development of AMR due to the mutation of genes, the formation of biofilm, and the modification of enzymes.This alarming situation has caused the creation of new alternative antibacterial materials, such as nanoparticles.Nanoparticles are emerging as a promising solution due to multiple and unique mechanisms of action to prevent bacteria from developing resistance and help to control the worldwide problem of bacterial resistance.Metal nanoparticles such as silver, gold, zinc, and titanium oxide have been synthesized by chemical, physical, and biological methods, and they have strong antibacterial properties.Mechanisms of nanoparticles include disruption of cell membrane integrity, DNA damage, destruction of biofilm production, and enzyme denaturation.They attach to DNA, inhibiting replication and transcription.But the usage of nanoparticles also exhibits toxicity.They harm the beneficial bacteria, accumulate in the body, cause organ damage, and develop neurotoxicity and hepatotoxicity.Further research is needed in the future to develop a more potent antimicrobial agent that has the potential to hinder the spread of antibiotic resistance against bacteria. Mechanism (biology) ; Antimicrobial ; Nanotechnology ; Biochemical engineering ; Materials science ; Microbiology ; Engineering ; Biology ; Epistemology ; Philosophy Nanoparticles: synthesis and applications
Authors: Imelda Fajriati | Priyagung Dhemi Widiakongko | Didik Krisdiyanto | Heti Hermawati
Source: BULLETIN OF CHEMICAL REACTION ENGINEERING AND CATALYSIS (article, 2025-12-03)
Field: Materials Science — Materials Chemistry

Green Synthesis of ZnO Nanoparticles using Aloe Vera Extract and Xanthan Gum as Modifier for Photocatalytic Degradation of Anionic and Cationic Dye in Aqueous Solution The green synthesis of Zinc Oxide (ZnO) nanoparticles is a simpler, low-energy method that avoids toxic chemicals, making the process more cost-effective and environmentally friendly. The green synthesis was performed using aloe vera extract (55% - Aloin), rich in electrons from its hydroxyl groups, as a reducing agent, and natural polysaccharides from xanthan gum to disperse particles and prevent agglomeration. The green synthesis product was characterized using scanning electron microscopy, Fourier Transform spectroscopy, X-ray diffraction, transmission electron microscopy, and Diffuse Reflectance UV spectroscopy. The green-synthesized ZnO nanoparticles, both with xanthan gum (ZnO-AL/XG) and without xanthan gum (ZnO-AL), adopted a hexagonal wurtzite crystal structure. The addition of xanthan gum significantly reduced the crystallite size and enhanced the surface homogeneity of the photocatalyst. Over 50% removal of both anionic and cationic dyes was achieved by ZnO-AL/XG for up to 3 uses, and by ZnO-AL for up to 2 uses, respectively. These findings highlight the potential of the aloe vera–xanthan gum-based green synthesis as a sustainable and efficient strategy for producing ZnO nanomaterials applicable in dye wastewater treatment. Copyright © 2026 by Authors, Published by BCREC Publishing Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0). Xanthan gum ; Aloe vera ; Aqueous solution ; Cationic polymerization ; Zinc ; Nanomaterials ; Photocatalysis ; Nanoparticle ZnO doping and properties ; Magnesium Oxide Properties and Applications ; Nanoparticles: synthesis and applications
Authors: Shashikant Dhole | Shrikrishna Baokar | Rajendra Patil
Source: International Journal of Pharmaceutical Sciences Review and Research (article, 2025-07-01)
Field: Materials Science — Biomaterials

Nanoparticles as Advanced Drug Delivery Systems: Innovations, Mechanisms, and Pharmaceutical Applications: A Review Nanoparticles are revolutionizing the delivery of pharmaceutical drugs by providing creative answers to some of the most significant problems with conventional treatments, including inadequate bioavailability, poor water solubility, and lack of tailored delivery.These microscopic carriers contribute to increased therapeutic efficacy and decreased undesirable side effects by permitting controlled and site-specific medication release.For drug delivery, a large range of nanoparticle types have been investigated, including dendrimers, metallic particles, polymeric nanoparticles, lipid-based systems, and carbon-based nanostructures.Treatments for diseases including cancer, neurological disorders, and infectious diseases have already showed promise due to their special capacity to penetrate biological barriers and interact with particular cells in a targeted manner.The classification, manufacturing, and functionality of these nanoparticles when they are loaded with medicinal compounds are all examined in further detail in this paper.It also discusses significant safety and regulatory issues, as well as their present medical use, including formulations that have FDA approval.Lastly, it examines fascinating new discoveries that are advancing our understanding of genuinely customized treatment alternatives, such as multifunctional nanoparticles and the application of artificial intelligence in the creation of next-generation nanomedicines. Drug delivery ; Nanotechnology ; Drug ; Nanoparticle ; Pharmaceutical sciences ; Computer science ; Business ; Materials science ; Medicine ; Pharmacology Nanoparticle-Based Drug Delivery ; Curcumin's Biomedical Applications
Authors: Ms. Vaishnavi S. Tanwade MsVaishnavi S. Tanwade | A.V. Moholkar | Kishor Otari
Source: International Journal of Pharmaceutical Research and Applications (article, 2025-02-01)
Field: Materials Science — Biomaterials

“Pharmaceutical Nanoparticles: Detailed Review of Types, Preparation Methods, and Applications” Nanoparticles are emerging as pivotal components in the development of novel drug delivery systems (NDDS), significantly enhancing the efficacy, bioavailability, and targeted delivery of therapeutics across various medical fields, including cancer therapy, cardiovascular treatment, and vaccine development. This review explores the synthesis methods, structural characteristics, and functionalization of nanoparticles that enable their role as advanced pharmaceutical carriers. The unique properties of nanoparticles, such as their nanoscale size and high surface area-to-volume ratio, facilitate improved drug solubility and permeability, while also allowing for stimuliresponsive release mechanisms. By integrating personalized medicine approaches, these systems aim to address the limitations of conventional drug delivery methods, including adverse effects and poor bioavailability. Additionally, safety and toxicity concerns associated with the use of nanoparticles in medical applications are discussed, emphasizing the need for comprehensive evaluation in the context of nanomedicine. This work underscores the transformative potential of nanotechnology in revolutionizing pharmaceutical practices and improving therapeutic outcomes.Recent developments in nanomedicine have broadened the utility of nanoparticles in cancer therapy, cardiovascular treatments, respiratory disorders, and vaccine innovation, while their integration with imaging, diagnostics, and biosensing technologies has significantly enhanced disease detection and monitoring capabilities. Nonetheless, the field faces challenges, including toxicity concerns, large-scale production issues, and regulatory hurdles that hinder the progression of nanoparticle-based drug development. Ongoing research efforts are focused on addressing these challenges, refining nanoparticle technologies to ensure safer and more effective pharmaceutical applications. As advancements continue, nanoparticles are poised to redefine medicine, facilitating more precise, efficient, and personalized treatment options Nanoparticle ; Nanotechnology ; Computer science ; Materials science Nanoparticle-Based Drug Delivery
Authors: Ravindra Waykar | Srinivasakumar Kumarapillai
Source:  (preprint, 2025-01-14)
Field: Chemistry — Organic Chemistry

Silver and Iron Nanoparticles: Green Synthesis and Characterization ABSTRACT:Biosynthesized nanoparticles (NPs) are gaining traction because they leverage physiologically active plant secondary metabolites, enabling eco-friendly synthesis and offering exclusive biological benefits. This innovative nanomedicine technology shows great promise in medicine, providing a novel method for drug delivery and treatment. The advancement of biosynthesized nanomedicine has notable implications for the pharmaceutical and medical sectors, presenting a more precise and effective way to address diseases. This paper introduces a cost-effective, environmentally friendly, and dependable method for synthesizing silver and iron NPs. The method involves employing the aqueous leaf extract of Vallisneria spiralis Linnaeus. The biosynthesized NPs were analyzed utilizing several methods, including transmission electron microscope (TEM), dynamic light scattering (DLS), UV−visible spectroscopy, and ICP-MS.Keywords: Vallisneria spiralis, Ag-NPs, Fe-NPs, Green synthesis, Characterization. Characterization (materials science) ; Nanoparticle ; Nanotechnology ; Silver nanoparticle ; Materials science ; Chemical engineering ; Business ; Engineering Nanomaterials for catalytic reactions ; Chemistry and Chemical Engineering ; Sustainability and Innovation in Business
Authors: Prashant Halagali - | Bhuvaneshwari R. Sharannavar -
Source: International Journal on Science and Technology (review, 2025-05-14)
Field: Materials Science — Materials Chemistry

The Hot Melt Extrusion (HME) in Pharmaceutical Technology: A Comprehensive Review Hot Melt Extrusion (HME) is an innovative and versatile technology that has significantly impacted pharmaceutical formulation and drug delivery. Originally developed for the plastics industry, HME has been successfully adapted for pharmaceutical use due to its solvent-free and continuous processing capabilities. It is particularly beneficial for enhancing the solubility and bioavailability of poorly water-soluble drugs. The process involves the application of heat and shear force to produce homogeneous extrudates, enabling the development of solid dispersions, controlled-release formulations, and complex drug delivery systems. Twin-screw extruders are commonly preferred over single-screw systems due to their superior mixing efficiency and scalability. HME offers several advantages, including improved drug stability, enhanced patient compliance, and environmental friendliness. However, challenges such as thermal degradation of heat-sensitive drugs and the need for specialized equipment remain. Critical process parameters—including temperature, screw speed, and feed rate—must be carefully optimized. A wide range of materials, such as pharmaceutical-grade polymers and plasticizers, are employed, with appropriate selection being essential for desired drug release and stability. Characterization techniques like DSC, TGA, XRD, and FTIR help evaluate drug-polymer interactions and extrudate properties. Emerging innovations, such as 3D printing integration and real-time process monitoring, are expanding the potential of HME, particularly in personalized medicine and continuous manufacturing. Extrusion ; Materials science ; Metallurgy Crystallization and Solubility Studies ; Drug Solubulity and Delivery Systems
Authors: Mohammed Mahbubul Islam | Shamima Akhter | Amar G. Chittiboyina | Srinivasa Rao Baratam
Source: International Journal of Research Publication and Reviews (article, 2025-09-01)
Field: Materials Science — Biomaterials

Conventional and Smart Nanocarriers for Oral and Targeted Drug Delivery: From Liposomes to Exosomes Although oral and targeted drug delivery still remains the major focus of today's pharmaceutics, legacy dosage forms often suffer from poor absorption, low solubility, enzymatic breakdown, and non-uniform distribution.The challenges and complications could be resolved further, and the therapeutic outcomes could be improved by using smart nanocarriers that support tailored functionalization strategies.Intelligent nanocarriers that integrate passive and active targeting, stimuliresponsive behaviour and biomimetic features can achieve target-selective site-specific delivery with reduced systemic toxicity, better bioavailability and the capability of protecting fragile molecules.There have been many platforms which have demonstrated great potential in oral and targeted approaches specifically for biologics and anticancer therapy.These carriers are liposomes, polymeric nanoparticles, solid lipid carriers, dendrimers, as well as exosomes.Apart from current challenges associated with clinical translation and regulatory approval, this review also describes the basics, methods of functionalization and applications of intelligent nanocarriers.Finally, perspectives for the future are provided with regard to the impact of theragnostic platforms, personalized nanomedicine and next-generation biomimetic systems on oral and targeted drug dosing in the near future. Nanocarriers ; Liposome ; Microvesicles ; Drug ; Targeted drug delivery ; Drug delivery Nanoparticle-Based Drug Delivery ; Advanced Drug Delivery Systems ; Curcumin's Biomedical Applications
Authors: Priyadharsini Shanumuganandam | Sathiamoorthi Thangavelu
Source: Research Square (preprint, 2025-09-09)
Field: Materials Science — Materials Chemistry

Biogenic and green approach for ZnO nanoparticle synthesis via Bacillus licheniformis and their antimicrobial and anticancer potential Nanoparticle ; Antimicrobial ; Cytotoxicity ; Zinc ; Bacillus licheniformis ; Cancer cell ; Fourier transform infrared spectroscopy ; Bacteria Nanoparticles: synthesis and applications ; Advanced Nanomaterials in Catalysis ; Nanoplatforms for cancer theranostics