jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Natalya Seraya | Valery Chernavin | Gulzhan Daumova | Sergey Mirgorodsky | Raigul Ramazanova
Source: Bulletin of D Serikbayev EKTU (article, 2025-09-30)
Field: Materials Science — Materials Chemistry

DEVELOPMENT OF HEAT-RESISTANT CONCRETE BASED ON CORUNDUM MATERIALS FROM MAN-MADE WASTE The article presents the results of the development of heat-resistant concrete using technogenic wastes containing corundum. An aluminophosphate binder was employed as the binding component, while refractory clay was used to modify the composition. Experimental studies demonstrated that the incorporation of clay and the optimization of component ratios significantly improved the performance characteristics of the concrete, particularly its strength and resistance to thermal loads. It was established that the optimal ratio of components increased the compressive strength to 62–65 MPa under normal conditions, with the best specimens reaching up to 75 MPa. After heat treatment at 1000 °C, the compressive strength remained in the range of 30–40 MPa, which corresponds to more than 60% of the initial value. The ultimate load-bearing capacity of the specimens reached 168 kN, confirming the high structural performance of the material. The density of the specimens was 2.8–2.9 g/cm³, while water absorption did not exceed 6–7%, which meets the requirements for heat-resistant composite materials. Microstructural analysis confirmed the formation of a thermally stable phosphate matrix with a uniform distribution of corundum grains. The obtained results confirm the applicability of the developed material under high-temperature service conditions, particularly for the lining of thermal units in metallurgical industries Corundum ; Compressive strength ; Absorption of water ; Composite number ; Thermal ; Microstructure ; Matrix (chemical analysis) ; Service life Magnesium Oxide Properties and Applications ; Innovations in Concrete and Construction Materials ; Concrete and Cement Materials Research
Authors: Kanong Ruttanakorn | Thana Thanayutsiri | Praneet Opanasopit | Tanasait Ngawhirunpat | Akhayachatra Chinsriwongkul | Theerasak Rojanarata
Source: Pharmaceutical Sciences (article, 2025-10-11)
Field: Chemistry — Analytical Chemistry

Green HPLC Assay for Captopril Tablets with Integrated Laboratory Waste Management: A Paradigm of Sustainable Pharmaceutical Analysis Workflow Enabled by Agro-Waste-Derived Products Background: Sustainable pharmaceutical analysis is essential for reducing environmental impacts from hazardous reagents, solvents, and residual active pharmaceutical ingredients (APIs). This study aimed to develop a green and practical workflow by integrating an eco-friendly analytical method with an effective post-analysis waste treatment approach, using captopril (CTP) as a case study. Methods: A high-performance liquid chromatographic (HPLC) method was developed for rapid, simultaneous quantification of CTP and its impurity, captopril disulfide (CDS), in tablet formulations. Bioethanol derived from sugarcane molasses was used as a greener alternative to conventional solvents. A 10 cm C18-column was employed to address ethanol-associated backpressure. The method was validated following ICH and United States Pharmacopeia (USP) guidelines. In parallel, a laboratory waste treatment protocol was developed using coconut shell-derived activated carbon, applied at ambient temperature (25 °C). Results: The optimized HPLC method, utilizing a mobile phase of ethanol, water, and phosphoric acid (35:65:0.05, v/v/v), operated at a flow rate of 1.5 mL/min and a column temperature of 40 °C, effectively resolved CTP and CDS within 2.5 min, allowing for high-throughput analysis and reduced energy consumption. It demonstrated excellent linearity, accuracy, precision, sensitivity, specificity, and robustness. Its performance was comparable to the USP reference method, with the added benefits of improved greenness and practicality. Treatment of the laboratory waste liquid by shaking with activated carbon at a 1:10 g/mL ratio removed over 99% of CTP within 5 min. Conclusion: This is the first ethanol-based HPLC assay for CTP, offering a greener alternative to existing methods. The integrated waste management strategy effectively reduces risk of API dissemination into the environment, addressing both ecological and public health concerns. Utilizing agro-waste in both analysis and waste treatment promotes resource efficiency and supports circular economy principles. This model contributes to sustainable pharmaceutical quality control in line with the Sustainable Development Goals. Captopril ; Hazardous waste ; Phosphoric acid ; Pharmaceutical formulation ; Workflow ; High-performance liquid chromatography Analytical Methods in Pharmaceuticals ; Computational Drug Discovery Methods ; Chemistry and Chemical Engineering
Authors: Suci Ananda Putri | Yahdiana Harahap | Silvia Surini
Source: Journal of Applied Pharmaceutical Science (article, 2025-01-01)
Field: Chemistry — Organic Chemistry

Bioanalytical method development and validation for the pharmacokinetics and biodistribution study of pirfenidone-loaded solid lipid nanoparticles Pirfenidone (PRF) is a synthetic compound used to treat idiopathic pulmonary fibrosis, but its oral administration may cause systemic side effects. This study aimed to develop and validate a bioanalytical method to quantify PRF and evaluate the pharmacokinetic and biodistribution profile of PRF-loaded solid lipid nanoparticles (SLNs) delivered via the pulmonary route. A high-performance liquid chromatography (HPLC) method was validated following the Food and Drug Administration (FDA) guidelines, showing acceptable selectivity, accuracy, precision, and stability in plasma and lung tissue. PRF SLNs were prepared by solvent injection and had a mean particle size of 240.3 ± 3.57 nm and a polydispersity index of 0.386–0.392. Intratracheal administration of PRF SLNs resulted in higher maximum concentration and Area Under the Curve (AUC) values than oral PRF. Biodistribution studies showed that PRF SLNs achieved approximately fivefold greater AUC in lung tissue than free PRF, with lower distribution in the liver and kidneys. These findings indicate that pulmonary PRF SLNs enhance lung targeting and may reduce systemic exposure, while the validated HPLC method supports reliable pharmacokinetic and tissue distribution analysis. Biodistribution ; Pharmacokinetics ; Bioanalysis ; Solid lipid nanoparticle ; Dispersity ; Distribution (mathematics) ; Tissue distribution ; Particle size Synthesis and biological activity ; Cancer therapeutics and mechanisms ; thermodynamics and calorimetric analyses
Authors: Elena Trukhan | Nakib H. Protik
Source: ArXiv.org (preprint, 2025-12-04)
Field: Materials Science — Materials Chemistry

Interband and kinetic corrections to the electronic Boltzmann transport equation Interband effects such as coherence/tunneling have recently been shown to give an important contribution to the charge and heat transport properties under certain conditions. These can be captured by adding corrective terms to the semiclassical Boltzmann transport equation. In recent derivations of this type of transport equations that are based on the density matrix formalism, there remain, however, certain omissions. These derivations also rely on a particular type of relaxation time approximation and a band-diagonal form of the interaction self-energies. In this work we derive the interband terms of the electronic Boltzmann transport equation starting from the Keldysh formulation of the quantum kinetic equation and considering the band non-diagonality of the electron-impurity and electron-phonon self-energies. We introduce a minimally modified Kadanoff-Baym Ansatz, and find a quantum-corrected, matrix Boltzmann transport equation that is well beyond the current state of the art theory. We show that the occupations and coherences are interdependent, and that the kinetic corrections due to the included interactions cannot, in general, be ignored. This work clarifies the various approximations that must be introduced in an ab initio derivation of Boltzmann-like equations and finds a new matrix Boltzmann transport equation that is suitable for parameters-free numerical implementations. Boltzmann equation ; Semiclassical physics ; Boltzmann constant ; Density matrix ; Work (physics) ; Relaxation (psychology) ; Kinetic energy ; Matrix (chemical analysis) Thermal properties of materials ; Advancements in Semiconductor Devices and Circuit Design ; Molecular Junctions and Nanostructures
Authors: Anna Rozsályi
Source: Papers in Arts and Humanities (article, 2025-02-04)
Field: Chemistry — Organic Chemistry

The Spice Melange as a Catalyst to the Discovery of the Mind Melange, or spice as it is also known, is an ingredient in Frank Herbert's novel Dune. It symbolizes the infinite possibilities of the human mind, as it is a source of knowledge and power. Both addictive and mind-altering, for the people of Arrakis, its source place, the spice is the basis of their lives and the cornerstone of their daily rituals. Due to its effect, the traditional lifespan is extended three times, but at the same time, its consumption causes a strong addiction. It is the basis of the rites of passage. The spice is a consciousness-expanding narcotic produced during the natural life cycle of sandworms, which has been the core of technological development and commerce since its discovery. Moreover, the formation of the cultural memory of the Fremen is made possible by the Water of Life, a substance transformed from poison and heavily saturated with spice. In tribal society, constant contact with the spice also manifests in physical changes, as the natural layer of their eyes turns otherworldly blue due to consumption. In my study, I address the following questions: can spice as a drug fully enhance the capabilities of the human mind? What is its role in the rites, and how does it enable the cultural memory of the tribe? What do various interest groups in the galaxy use it for? The core of my topic is the relationship between the spice and the individual through different social strata, ritual ceremonies, and the question of foresight. Spice ; Catalysis ; Chemistry ; Engineering ; Electrical engineering ; Organic chemistry Chemical synthesis and alkaloids ; Academic and Historical Perspectives in Psychology
Authors: Tri Mulyanto | Firda Aulya Syamani | Ismadi Ismadi | Deni Purnomo | Mona Nurjanah | Iman Setyadi | Abdul Azis Abdillah | Sulaksana Permana
Source: Eastern-European Journal of Enterprise Technologies (article, 2025-08-27)
Field: Materials Science — Polymers and Plastics

Identifying the mechanical properties and surface morphology of artocarpus elasticus fiber biocomposites due to the effect of alkali treatment for automotive applications Lantung bark (Artocarpus elasticus), a natural fiber abundant in Bengkulu and other Indonesian regions, was studied as reinforcement in polyester-based biocomposites. The increasing demand for environmentally friendly materials has driven the development of natural fiber-based biocomposites as alternatives to synthetic materials. The main problem addressed is the weak interfacial bonding between untreated Lantung fibers and polymer matrices, reducing composite mechanical performance. To overcome this, fibers were treated with Sodium Hydroxide (NaOH) solutions at 2%, 4%, and 6% concentrations for 2 hours to improve surface morphology and chemical reactivity. After drying, treated fibers were fabricated into biocomposites using the hand lay-up pressing method. Testing included morphological observation via 3D microscopy and mechanical evaluation through tensile and bending tests based on ASTM standards. Results showed that 2% NaOH treatment provided the best biocomposite’s mechanical properties, with a Modulus of Rupture (MOR) of 82.41 MPa and a Modulus of Elasticity (MOE) of 4.71 GPa. These improvements are explained by effective removal of surface impurities without significant fiber damage, enhancing fiber-matrix adhesion. The distinctive feature of this study is identifying an optimal alkali concentration that maintains fiber integrity while significantly improving mechanical performance. The developed Lantung biocomposites have potential applications as eco-friendly interior or non-structural automotive components requiring moderate tensile strength and high flexural performance Automotive industry ; Materials science ; Morphology (biology) ; Composite material ; Alkali metal ; Fiber ; Polymer science ; Chemistry ; Engineering ; Organic chemistry Natural Fiber Reinforced Composites ; Textile materials and evaluations ; Bamboo properties and applications
Authors: Mohan Akshaya | R Renuka | K. K. Kumar | M. Mohanalakshmi | N. Thavaprakaash | K Hemaprabha
Source: Plant Science Today (article, 2025-11-13)
Field: Chemistry — Inorganic Chemistry

Ethnobotany of coconut: A review on its traditional, cultural and economic significance Cocos nucifera L. (2n = 2x = 32), the only species within the genus Cocos, is a diploid perennial oilseed plant belonging to the Arecaceae family, earning its’ title as “Kalpavriksha or Tree of Heaven”. Coconut palm holds enormous cultural, traditional, and economic significance across tropical and subtropical regions. Originating from the land fragments of the ancient Gondwana landmass, coconut has undergone wide geographic dispersal and ecological adaptation, thriving along coastal areas from Pacific regions. Despite its significance, ethnobotanical research on coconut remains limited and coconut cultivation faces increasing threats from rapid urbanization. In India, coconut is deeply integrated into indigenous health systems, used for its ethnomedicinal properties including analgesic, anti-inflammatory, cardioprotective, antidiabetic, antioxidant, antibacterial and immunomodulation. Coconut contains high levels of fatty acids such as caprylic acid (9%), capric acid (8%), caproic acid (5%) and myristic acid (20%) which enhances its potential in nutritional therapy and functional food development. This review integrates phytochemical, pharmacological and ethnobotanical evidence, emphasizing coconut’s potential in food, medicine, and sustainable development. Cocos nucifera L. (2n = 2x = 32), the only species within the genus Cocos, is a diploid perennial oilseed plant belonging to the Arecaceae family, earning its title as “Kalpavriksha” or “Tree of Heaven”. Despite its widespread cultural, traditional and economic importance, ethnobotanical research remains limited and cultivation faces increasing threats from urbanization. Originating from the land fragments of the ancient Gondwana landmass, coconut has undergone wide geographic dispersal and ecological adaptation, thriving particularly along the coastal areas of the Pacific and Indian Ocean regions. In India, coconut is deeply integrated into indigenous health systems, used for its ethnomedicinal properties including analgesic, anti-inflammatory, cardioprotective, antidiabetic, antioxidant, antibacterial and immunomodulatory activities. It is rich in fatty acids such as caprylic, capric, caproic and myristic acids, enhancing its potential in nutritional therapy and functional food development. This review integrates phytochemical, pharmacological and ethnobotanical evidence, emphasizing coconut’s potential in food, medicine and sustainable development. Cocos nucifera ; Ethnobotany ; Arecaceae ; Capric Acid ; Genus ; Biological dispersal ; Perennial plant ; Subtropics Coconut Research and Applications ; Plant-Derived Bioactive Compounds ; Date Palm Research Studies
Authors: Qazi Amir Ijaz | Mohammad A. A. Ibrahim | Yasir Mehmood | Bilal Khalid | Muhammad Affan | Naila Abdul Sattar
Source: Currents in pharmaceutical research (article, 2025-04-28)
Field: Chemistry — Analytical Chemistry

Validation of an RP-HPLC Method to Determine Rupatadine as a Fumarate in Pharmaceutical Dosage Form Rupatadine (RUP) is a second generation antihistamine drug and an agonist of platelets activating factor. Literature does not report any specific method for the determination of RUP. Therefore, a Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method was developed in this research for the quantitative determination of RUP in pharmaceutical dosage form. For this purpose, a mixture of monosodium phosphate buffer and acetonitrile 80:20 v/v was used as mobile phase, flowing at a rate of 1.0 ml/min. A well-characterized reference material of RUP with a potency of 99.68% (as is basis) was used throughout the study. RUP for system suitability chemical related substances (CRS) (containing impurities A and B) was also used in this study for the identification of fumaric acid, impurity A, impurity B, and RUP in the pharmaceutical dosage form. Method validation was performed by the preliminary analysis of the standard sample and by performing recovery studies. The method was found to be linear with regression line y = 95464x -6164, having correlation 1.0000, in the range of 17.04-85.20 µg/ml. Moreover, percentage recovery of RUP was found to be in the range of 99.08 to 100.25. The limit of detection (LOD) was found to be 0.63 µg/ml and the limit of quantification (LOQ) was found to be 1.91µg/ml. It can be inferred from the obtained results that the developed method is simple, linear, precise, accurate, and robust. Therefore, it can be employed for the quantitative determination of RUP in the pharmaceutical dosage form. Dosage form ; Chromatography ; High-performance liquid chromatography ; Chemistry ; Pharmacology ; Medicine Analytical Methods in Pharmaceuticals ; Synthesis and Biological Evaluation ; Inorganic and Organometallic Chemistry
Authors: Liliya Logoyda | Mariana Horyn | Liubomyr Kryskiw | Tetyana Kucher | Nadiya Zarivna | Nataliia Shulyak | Iryna Ivanchuk
Source: ScienceRise Pharmaceutical Science (article, 2025-06-30)
Field: Chemistry — Analytical Chemistry

Spectrophotometric determination of nimodipine, nitrendipine, lacidipine in tablets via derivatization with para-dimethylaminobenzaldehyde The proposed approach involves the interaction of NIM, NIT, and LAC directly with DABA reagent to produce coloured products with its further spectrophotometric analysis by the development of simple, available, and alternative spectrophotometric methods. Material and methods: UV-visible double beam spectrophotometer Shimadzu UV-1800 (Japan) with included UV-Probe version 2.62 software was employed. Additional equipment included a precise analytical balance RAD WAG AS 200/C (Poland), an ultrasonic bath Elmasonic EASY 60H with a frequency of 40 kHz and a water bath VB-4 were used in the developed procedure. LAC, NIM and NIT (purity ≥98% (HPLC)) were supplied from Sigma-Aldrich Chemicals Co. (St. Louis, MO, USA). NIT 10 mg tablets, NIM 30 mg tablets were purchased from local drugstore. LAC 2 mg tablets were purchased from europharm.com.ua. Methanol was produced by Honeywell and had a purity of 99.9%. HCl conc. (fuming, by Sigma Aldrich was used. DABA utilized in the experiment was analytical grade. Results and discussion: Simple, available and alternative visible spectrophotometric methods for the determination of nitrendipine (NIT), nimodipine (NIM), and lacidipine (LAC) in tablets through derivatization with the para-dimethylaminobenzaldehyde (DABA) have been developed. The optimal parameters for CCBs spectrophotometric analysis were as follows: detection wavelength - 577 nm for NIM, NIT and 616 nm for LAC, concentrated hydrochloric acid, 1.5 mL of 0.1% DABA solution, 15 min boiling at 100 °C. The concentration was linearly proportional to absorbance values in the range of 25 – 175 μg/mL (NIT), 25 – 200 μg/mL (NIM), 20 – 200 μg/mL (LAC). Estimation of LOD and LOQ parameters were obtained as 3.75 μg/mL and 11.38 μg/mL (NIT), 4.43 μg/mL and 13.43 μg/mL (NIM), 6.30μg/ml and 19.1μg/mL (LAC). Conclusions. In this work, thorough scientific research was carried out with the presentation of the method of selection of the optimal reaction conditions and spectrophotometric methods for determining NIT, NIM, and LAC in tablets were developed. In addition, the three studied CCBs were quantified using easy-to-implement, simple, cost-effective spectrophotometric approaches. The proposed methods can be used as alternatives and arbitrage, which significantly expands the bank of analytical methods. Moreover, the described methods can be easily implemented for routine pharmaceutical analysis Nimodipine ; Lacidipine ; Nitrendipine ; Derivatization ; Chromatography ; Chemistry ; High-performance liquid chromatography ; Organic chemistry ; Calcium ; Antagonist Analytical Methods in Pharmaceuticals ; Analytical Chemistry and Chromatography ; Inorganic and Organometallic Chemistry
Authors: Anju Chettri | Bhupendra Shrestha
Source: Journal of Applied Pharmaceutical Science (article, 2025-01-01)
Field: Chemistry — Analytical Chemistry

Development of spectrophotometric methods for simultaneous determination of Diltiazem and Naringin Novel, simple, and accurate spectrophotometric techniques, i.e., the Q-ratio method and absorptivity factor method were developed to simultaneously estimate Diltiazem and Naringin in a synthetic mixture. In the Q-ratio method, the analytical wavelengths used for the estimation of two drugs were 257 and 275 nm. The method was based on the measurement of absorbance at two different wavelengths, one of which is taken as the λmax of naringin and the other from the isoabsorptive point discovered by overlapping the spectra of two drugs. Whereas for the absorptivity factor method, the analytical wavelengths used were the absorptivity factor points, i.e., 229 and 247 nm obtained after overlapping the spectra of Diltiazem and Naringin at different concentrations. For both methods, methanol was used as a solvent. In these two developed and validated methods, the correlation coefficient observed for linearity was near 1, and the % RSD for precision was less than 2%. All other validation parameters conducted passed the criteria set forth in the International Conference on Harmonization guidelines. Therefore, these techniques can be successfully used for routine quality control tests. Naringin ; Diltiazem ; Chromatography ; Chemistry ; Organic chemistry ; Calcium Analytical Methods in Pharmaceuticals ; Synthesis and biological activity ; Analytical Chemistry and Chromatography