jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Che‐Fan Huang | Jake Kline | Fernanda Negrão | Matthew T. Robey | Timothy K. Toby | Kenneth R. Durbin | Ryan T. Fellers | John J. Friedewald | Josh Levitsky | Michaël Abécassis | Rafael D. Melani | Neil L. Kelleher | Luca Fornelli
Source: Analytical Chemistry (article, 2024-02-14)
Field: Chemistry — Spectroscopy

Targeted Quantification of Proteoforms in Complex Samples by Proteoform Reaction Monitoring Existing mass spectrometric assays used for sensitive and specific measurements of target proteins across multiple samples, such as selected/multiple reaction monitoring (SRM/MRM) or parallel reaction monitoring (PRM), are peptide-based methods for bottom-up proteomics. Here, we describe an approach based on the principle of PRM for the measurement of intact proteoforms by targeted top-down proteomics, termed proteoform reaction monitoring (PfRM). We explore the ability of our method to circumvent traditional limitations of top-down proteomics, such as sensitivity and reproducibility. We also introduce a new software program, Proteoform Finder (part of ProSight Native), specifically designed for the easy analysis of PfRM data. PfRM was initially benchmarked by quantifying three standard proteins. The linearity of the assay was shown over almost 3 orders of magnitude in the femtomole range, with limits of detection and quantification in the low femtomolar range. We later applied our multiplexed PfRM assay to complex samples to quantify biomarker candidates in peripheral blood mononuclear cells (PBMCs) from liver-transplanted patients, suggesting their possible translational applications. These results demonstrate that PfRM has the potential to contribute to the accurate quantification of protein biomarkers for diagnostic purposes and to improve our understanding of disease etiology at the proteoform level. Chemistry ; Proteomics ; Selected reaction monitoring ; Quantitative proteomics ; Computational biology ; Label-free quantification ; Biomarker ; Biomarker discovery ; Mass spectrometry ; Tandem mass spectrometry ; Chromatography ; Biochemistry Advanced Proteomics Techniques and Applications ; Mass Spectrometry Techniques and Applications ; Advanced Biosensing Techniques and Applications
Authors: Xiaolin Liu | Taeyoung Ki | Guocheng Deng | Seungwoo Yoo | Kangjae Lee | Byoung‐Hoon Lee | Taeghwan Hyeon | Megalamane S. Bootharaju
Source: Nanoscale (article, 2024-01-01)
Field: Materials Science — Materials Chemistry

Recent advances in synthesis and properties of silver nanoclusters Achieving atomic precision in nanostructured materials is essential for comprehending formation mechanisms and elucidating structure-property relationships. Within the realm of nanoscience and technology, atomically precise ligand-protected noble metal nanoclusters (NCs) have emerged as a rapidly expanding area of interest. These clusters manifest quantum confinement-induced optoelectronic, photophysical, and chemical properties, along with remarkable catalytic capabilities. Among coinage metals, silver distinguishes itself for the fabrication of stable nanoclusters, primarily due to its cost-effectiveness compared to gold. This minireview provides an overview of recent advancements since 2020 in synthetic methodologies and ligand selections toward attaining NCs boasting a minimum of two free valence electrons. Additionally, it explores strategies for fine-tuning optical properties. The discussion extends to surface reactivity, elucidating how exposure to ligands, heat, and light induces transformations in size and structure. Of paramount significance are the applications of silver NCs in catalytic reactions for energy and chemical conversion, supplemented by in-depth mechanistic insights. Furthermore, the review delineates challenges and outlines future directions in the NC field, with an eye toward the design of new functional materials and prospective applications in diverse technologies, including optoelectronics, energy conversion, and fine chemical synthesis. Nanoclusters ; Nanotechnology ; Materials science Nanocluster Synthesis and Applications ; Laser-Ablation Synthesis of Nanoparticles
Authors: Krishanu Ghosal | Nagham Rashed | Bassma Khamaisi | Shady Farah
Source: Advanced Functional Materials (article, 2024-10-27)
Field: Materials Science — Polymers and Plastics

Precision 4D Printing of Multifunctional Olive Oil‐Based Acrylate Photo‐resin for Biomedical Applications Abstract Since the advent of 3D printing technology, a significant effort has been made to develop new 3D printable materials. Despite the recent progress in the field of 3D printing, the limited availability of photoactive resins has motivated continuous research endeavors to develop novel photoresins with multifunctional capabilities. Herein a biobased photoresin derived is reported from modified olive oil, designed for high‐resolution solvent‐free 4D printing with multifunctional capabilities. The physicochemical properties of the printed polymers are fine‐tuned using acrylic acid as a diluent cum comonomer. The mechanical properties of the printed polymers are similar to various soft tissues, such as ligaments, articular cartilage, and soft collagenous bone, showcasing its potential for soft tissue engineering applications. While the excellent temperature‐responsive shape memory 4D attributes coupled with exceptional antimicrobial properties toward gram‐negative and gram‐positive bacteria highlight the multifunctional nature of the printed polymers. Moreover, the printed polymers exhibited outstanding hemocompatibility and good cytocompatibility toward mouse fibroblast cells, suggesting their potential soft tissue engineering applications. In sum, the newly developed biobased resin can be employed to minimize the environmental impact of additive manufacturing while being competitive with existing fossil‐based photoresins, thereby meeting the growing demand for advanced photoresins with superior high‐resolution printing and smart properties for biomedical applications. Materials science ; Acrylate ; 3D printing ; Nanotechnology ; Olive oil ; Polymer science ; Process engineering ; Polymer ; Composite material Polymer composites and self-healing ; Photochromic and Fluorescence Chemistry ; Additive Manufacturing and 3D Printing Technologies
Authors: Muthanna J. Ahmed | Jaweria Ashfaq | Zainab Sohail | Iftikhar Ahmed Channa | Antoni Sánchez‐Ferrer | Sheikh Nawaz Ali | Ali Dad Chandio
Source: Sustainable materials and technologies (review, 2024-08-08)
Field: Materials Science — Biomaterials

Lignocellulosic bioplastics in sustainable packaging – Recent developments in materials design and processing: A comprehensive review Bioplastic ; Manufacturing engineering ; Engineering ; Biochemical engineering ; Business ; Waste management biodegradable polymer synthesis and properties ; Nanocomposite Films for Food Packaging ; Advanced Cellulose Research Studies
Authors: Jiahao Wang | Ling Zhang | Yuxuan Ma | Wenna Xie | Jiehao Dong | Yujie Dong | Weijun Li | Cheng Zhang
Source: Chemical Engineering Journal (article, 2024-08-28)
Field: Materials Science — Polymers and Plastics

Construction of diverse adaptive camouflage nets based on soluble yellow-to-green switching electrochromic materials Electrochromism ; Camouflage ; Materials science ; Nanotechnology ; Chemistry ; Computer science ; Artificial intelligence ; Electrode Transition Metal Oxide Nanomaterials ; Olfactory and Sensory Function Studies ; Polydiacetylene-based materials and applications
Authors: Laxmi Sai Viswanadha | Yashwanth Arcot | Yuting Lin | Mustafa Akbulut
Source: JCIS Open (article, 2024-07-06)
Field: Materials Science — Biomaterials

A comparative investigation of release kinetics of paclitaxel from natural protein and macromolecular nanocarriers in nanoscale drug delivery systems Understanding the release behaviour of nanodrugs is a crucial step to better assess and control therapeutic outcomes and unfavourable side effects. Herein, we report a systematic study comparing the release kinetics and thermodynamics of paclitaxel (PTX) from supramolecularly assembled sub-micron particles based on natural macromolecules such as zein, whey, casein, bovine serum albumin (BSA) and conventional stabilizers such as pluronic F-127 (poloxamer 407), and β-cyclodextrin (β-CD) to gain insights into the role of carrier chemistry. For this purpose, nanomedicines with statistically indifferent sizes —in the range of 191.0 ± 0.8 nm (BSA) to 243.3 ± 11.6 nm (zein) were prepared (p > 0.05). The zeta potential values ranged from −3.2 ± 1.1 mV (pluronic F-127) to −17.2 ± 1.8 mV (whey) in phosphate buffered saline. The type of nanocarrier significantly influenced the long-term steady-state plateau of the release, resulting in a cumulative release of 70.3 ± 2.0 % of PTX from casein (the highest) and 46.8 ± 4.7 % of PTX from zein (the lowest). Time-resolved release data were analysed with various kinetical models, encompassing zero-order, first-order, Higuchi, Peppas-Sahlin, and Korsmeyer-Peppas kinetics. The analysis revealed that the Korsmeyer-Peppas model best captured the data. For these nanomedicines, the half-life of the encapsulated drugs was found to be 106.4 ± 31.3 h (zein), 4.7 ± 1.2 h (whey), 10.7 ± 1.8 h (pluronic F-127), 6.4 ± 0.9 h (casein), 10.8 ± 3.2 h (β-CD), and 4.0 ± 1.0 h (BSA). TEM characterization revealed differences in the macromolecular arrangement of the active ingredient within these nanocarriers, in addition to the structural differences among the various encapsulating agents. These differences manifested as variations in the internal nanostructures, leading to the creation of distinct microenvironments that could either facilitate or impede the movement of PTX molecules through the encapsulant matrices. In clinical settings, such fine details of nanocarrier design are important: by choosing the most appropriate nanocarrier (or their mixtures), clinicians can fine-tune drug administration to obtain the intended therapeutic window while mitigating the risk of potential negative reactions. Nanocarriers ; Kinetics ; Poloxamer ; Nanogel ; Chemistry ; Bovine serum albumin ; Casein ; Drug delivery ; Macromolecule ; Whey protein ; Chromatography ; Biochemistry ; Polymer ; Organic chemistry Nanoparticle-Based Drug Delivery ; Advanced Drug Delivery Systems ; Proteins in Food Systems
Authors: Nicholas D. Chiappini | Eric P. Geunes | Ethan T. Bodak | Robert R. Knowles
Source: ACS Catalysis (article, 2024-02-06)
Field: Chemistry — Organic Chemistry

Organobismuth Compounds as Aryl Radical Precursors via Light-Driven Single-Electron Transfer A light-driven method for the generation of aryl radicals from triarylbismuth(III) and (V) reagents is described. Aryl radical generation is proposed to occur through ligand-assisted mesolytic cleavage of an organobismuth(IV) intermediate generated from either oxidation of Bi<sup>III</sup> or reduction of Bi<sup>V</sup>. This mode of aryl radical generation is demonstrated to be compatible with a range of bimolecular radical arylations, including hydroarylation of electron-deficient olefins and arylation of diboronates, disulfides, sulfonyl cyanides, phosphites and isocyanides. The intermediacy of an aryl radical is supported by radical trapping and radical clock experiments, and Bi<sup>IV</sup>-aryl mesolysis is supported computationally. Aryl ; Aryl radical ; Chemistry ; Radical ; Sulfonyl ; Reagent ; Radical ion ; Radical cyclization ; Photochemistry ; Electron transfer ; Photoredox catalysis ; Combinatorial chemistry ; Catalysis ; Medicinal chemistry ; Organic chemistry ; Photocatalysis ; Ion Radical Photochemical Reactions ; Sulfur-Based Synthesis Techniques ; Catalytic C–H Functionalization Methods
Authors: Minling Zhong | Yujie Sun
Source: Chem Catalysis (article, 2024-04-17)
Field: Materials Science — Materials Chemistry

Recent advancements in the molecular design of deep-red to near-infrared light-absorbing photocatalysts Photon upconversion ; Photocatalysis ; Absorption (acoustics) ; Nanotechnology ; Near-infrared spectroscopy ; Materials science ; Infrared ; Optoelectronics ; Ultraviolet ; Photochemistry ; Chemistry ; Optics ; Catalysis ; Physics ; Doping Luminescence and Fluorescent Materials ; Perovskite Materials and Applications ; Advanced Photocatalysis Techniques
Authors: Amir Khosravi | Razieh Habibpour | Maryam Ranjbar
Source: Scientific Reports (article, 2024-05-10)
Field: Chemistry — Inorganic Chemistry

Enhanced adsorption and removal of Cd(II) from aqueous solution by amino-functionalized ZIF-8 Zeolite imidazolate framework-8 (ZIF-8), which is a special subgroup of metal-organic frameworks (MOFs), was synthesized and modified by ethylenediamine (ZIF-8-EDA) to prepare an efficient adsorbent for the high sorption of Cd<sup>2+</sup> ions from solution. The synthesized and modified ZIF-8 (ZIF-8-EDA) were characterized by X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, Brunauer-Emmett-Teller (BET), field emission scanning electron microscopy (FE-SEM) with energy dispersive spectroscopy (EDS), and transmission electron microscopy (TEM) analysis. The optimum conditions for dosage of adsorbent, initial ion concentration, pH, and contact time were 0.05 g/l, 50 mg/l, 6, and 60 min, respectively, for cadmium ion sorption from aqueous solutions with a removal efficiency of 89.7% for ZIF-8 and 93.5% for ZIF-8-EDA. Adsorption kinetics and equilibrium data were analyzed using the Langmuir and Freundlich equations. The Langmuir model fitted the equilibrium data better than the Freundlich model. According to the Langmuir equation, the maximum uptake for the cadmium ions was 294.11(mg/g). The calculated thermodynamic parameters (ΔG°, ΔH°, and ΔS°) indicated that the adsorption process was feasible, spontaneous, and endothermic at 20-50 °C. Based on the results, the amino functionalized ZIF-8 had improved adsorption performance due to the replacing of the starting linker with organic ligands that had effective functional groups, leading to chemical coordination due to the interaction of metal ions with the non-bonding pair of electrons on the N atoms of the amino functional group. The selectivity toward metal ion adsorption by ZIF-8-EDA was Cd<sup>2+</sup> > Pb<sup>2+</sup> > Ni<sup>2+</sup>‏. Freundlich equation ; Adsorption ; Aqueous solution ; Langmuir ; Sorption ; Langmuir adsorption model ; Metal-organic framework ; Chemistry ; Fourier transform infrared spectroscopy ; Metal ions in aqueous solution ; Zeolitic imidazolate framework ; Inorganic chemistry ; Ethylenediamine ; Nuclear chemistry ; Physical chemistry ; Metal ; Chemical engineering ; Organic chemistry Metal-Organic Frameworks: Synthesis and Applications ; Adsorption and biosorption for pollutant removal ; Chemical Synthesis and Characterization
Authors: Ming Wang | Yiliang Lin
Source: Nanoscale (article, 2024-01-01)
Field: Materials Science — Materials Chemistry

Gallium-based liquid metals as reaction media for nanomaterials synthesis Gallium-based liquid metals (LMs) and their alloys have gained prominence in the realm of flexible and stretchable electronics. Recent advances have expanded the interest to explore the electron-rich core and interface of LMs to synthesize various nanomaterials, where Ga-based LMs serve as versatile reaction media. In this paper, we delve into the latest developments within this burgeoning field. Our discussion begins by elucidating the unique attributes of LMs that render them suitable as reaction media, including their high metal solubility, low standard reduction potential, self-limiting oxidation and ultra-smooth and "layer" surface. We then provide a comprehensive categorized summary of utilizing these features to fabricate a variety of nanomaterials, including pure metallic materials (metal alloys, metal crystals, porous metals, high-entropy alloys and metallic single atoms), metal-inorganic compounds (2D metal oxides, 2D metallic inorganic compounds and 2D graphitic materials), as well as metal-organic composites (metal-organic frameworks). This paper concludes by discussing the current challenges in this field and exploring potential future directions. The versatility and unique properties of Ga-based LMs are poised to play a pivotal role in the future of nanomaterial science, paving the way for more efficient, sustainable, and innovative technological solutions. Nanomaterials ; Nanotechnology ; Materials science ; Gallium ; Metal ; Liquid metal ; Electronics ; Limiting ; Metallurgy ; Chemistry ; Mechanical engineering ZnO doping and properties ; Advanced Sensor and Energy Harvesting Materials ; Aerogels and thermal insulation
Authors: Mingkai Zhang | Matthew Chapman | Bhagyesh R. Sarode | Bingcong Xiong | Hao Liang | James Chen | Eranthie Weerapana | James P. Morken
Source: Nature (article, 2024-08-21)
Field: Chemistry — Organic Chemistry

Catalytic asymmetric synthesis of meta benzene isosteres Catalysis ; Benzene ; Enantioselective synthesis ; Chemistry ; Combinatorial chemistry ; Organic chemistry Axial and Atropisomeric Chirality Synthesis ; Asymmetric Hydrogenation and Catalysis ; Synthesis and Properties of Aromatic Compounds
Authors: Sven van Vliet | Jinyu Sheng | Charlotte N. Stindt | Ben L. Feringa
Source: Nature Communications (article, 2024-07-31)
Field: Chemistry — Organic Chemistry

All-visible-light-driven salicylidene schiff-base-functionalized artificial molecular motors Light-driven rotary molecular motors are among the most promising classes of responsive molecular machines and take advantage of their intrinsic chirality which governs unidirectional rotation. As a consequence of their dynamic function, they receive considerable interest in the areas of supramolecular chemistry, asymmetric catalysis and responsive materials. Among the emerging classes of responsive photochromic molecules, multistate first-generation molecular motors driven by benign visible light remain unexplored, which limits the exploitation of the full potential of these mechanical light-powered systems. Herein, we describe a series of all-visible-light-driven first-generation molecular motors based on the salicylidene Schiff base functionality. Remarkable redshifts up to 100 nm in absorption are achieved compared to conventional first-generation motor structures. Taking advantage of all-visible-light-driven multistate motor scaffolds, adaptive behaviour is found as well, and potential application in multistate photoluminescence is demonstrated. These functional visible-light-responsive motors will likely stimulate the design and synthesis of more sophisticated nanomachinery with a myriad of future applications in powering dynamic systems. Molecular motor ; Molecular machine ; Supramolecular chemistry ; Photochromism ; Nanotechnology ; Visible spectrum ; Schiff base ; Photoluminescence ; Materials science ; Computer science ; Molecule ; Chemistry ; Optoelectronics Supramolecular Chemistry and Complexes ; Photochromic and Fluorescence Chemistry ; Luminescence and Fluorescent Materials
Authors: Quan Zuo | Yiping Li | Xuanliang Lai | Guangjun Bao | Lu Chen | Zeyuan He | Xinyi Song | E Ruiyao | Pengxin Wang | Yuntao Shi | Huixin Luo | Wangsheng Sun | Rui Wang
Source: Advanced Science (article, 2024-03-11)
Field: Chemistry — Organic Chemistry

Cysteine‐Specific Multifaceted Bioconjugation of Peptides and Proteins Using 5‐Substituted 1,2,3‐Triazines Peptide and protein postmodification have gained significant attention due to their extensive impact on biomolecule engineering and drug discovery, of which cysteine-specific modification strategies are prominent due to their inherent nucleophilicity and low abundance. Herein, the study introduces a novel approach utilizing multifunctional 5-substituted 1,2,3-triazine derivatives to achieve multifaceted bioconjugation targeting cysteine-containing peptides and proteins. On the one hand, this represents an inaugural instance of employing 1,2,3-triazine in biomolecular-specific modification within a physiological solution. On the other hand, as a powerful combination of precision modification and biorthogonality, this strategy allows for the one-pot dual-orthogonal functionalization of biomolecules utilizing the aldehyde group generated simultaneously. 1,2,3-Triazine derivatives with diverse functional groups allow conjugation to peptides or proteins, while bi-triazines enable peptide cyclization and dimerization. The examination of the stability of bi-triazines revealed their potential for reversible peptide modification. This work establishes a comprehensive platform for identifying cysteine-selective modifications, providing new avenues for peptide-based drug development, protein bioconjugation, and chemical biology research. Bioconjugation ; Biomolecule ; Cysteine ; Peptide ; Combinatorial chemistry ; Chemistry ; Triazine ; Surface modification ; Posttranslational modification ; Biochemistry ; Organic chemistry Click Chemistry and Applications ; Chemical Synthesis and Analysis ; Synthesis and Characterization of Heterocyclic Compounds
Authors: Mark Broadwin | Frances Imarhia | Amy Oh | Christopher R. Stone | Frank W. Sellke | Sankha Bhowmick | M. Ruhul Abid
Source: Bioengineering (review, 2024-02-25)
Field: Materials Science — Biomaterials

Exploring Electrospun Scaffold Innovations in Cardiovascular Therapy: A Review of Electrospinning in Cardiovascular Disease Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. In particular, patients who suffer from ischemic heart disease (IHD) that is not amenable to surgical or percutaneous revascularization techniques have limited treatment options. Furthermore, after revascularization is successfully implemented, there are a number of pathophysiological changes to the myocardium, including but not limited to ischemia-reperfusion injury, necrosis, altered inflammation, tissue remodeling, and dyskinetic wall motion. Electrospinning, a nanofiber scaffold fabrication technique, has recently emerged as an attractive option as a potential therapeutic platform for the treatment of cardiovascular disease. Electrospun scaffolds made of biocompatible materials have the ability to mimic the native extracellular matrix and are compatible with drug delivery. These inherent properties, combined with ease of customization and a low cost of production, have made electrospun scaffolds an active area of research for the treatment of cardiovascular disease. In this review, we aim to discuss the current state of electrospinning from the fundamentals of scaffold creation to the current role of electrospun materials as both bioengineered extracellular matrices and drug delivery vehicles in the treatment of CVD, with a special emphasis on the potential clinical applications in myocardial ischemia. Drug delivery ; Medicine ; Scaffold ; Disease ; Bioresorbable scaffold ; Extracellular matrix ; Nanofiber ; Tissue engineering ; Electrospinning ; Revascularization ; Biomedical engineering ; Myocardial infarction ; Nanotechnology ; Internal medicine ; Percutaneous coronary intervention ; Materials science ; Chemistry Electrospun Nanofibers in Biomedical Applications ; Tissue Engineering and Regenerative Medicine ; Advanced Sensor and Energy Harvesting Materials