jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Sadia Anjum | Faiza Naseer | Tahir Ahmad | Faryal Jahan | Halima Qadir | Rabia Gul | Kousain Kousar | Atif Sarwar | Abdallah Shabbir
Source: Scientific Reports (article, 2024-05-19)
Field: Materials Science — Biomaterials

Enhancing therapeutic efficacy: sustained delivery of 5-fluorouracil (5-FU) via thiolated chitosan nanoparticles targeting CD44 in triple-negative breast cancer Our current study reports the successful synthesis of thiolated chitosan-based nanoparticles for targeted drug delivery of 5-Fluorouracil. This process was achieved through the ionic gelation technique, aiming to improve the efficacy of the chemotherapeutic moiety by modifying the surface of the nanoparticles (NPs) with a ligand. We coated these NPs with hyaluronic acid (HA) to actively target the CD44 receptor, which is frequently overexpressed in various solid malignancies, including breast cancer. XRD, FTIR, SEM, and TEM were used for the physicochemical analysis of the NPs. These 5-Fluorouracil (5-FU) loaded NPs were evaluated on MDA-MB-231 (a triple-negative breast cell line) and MCF-10A (normal epithelial breast cells) to determine their in vitro efficacy. The developed 5-FU-loaded NPs exhibited a particle size within a favorable range (< 300 nm). The positive zeta potential of these nanoparticles facilitated their uptake by negatively charged cancer cells. Moreover, they demonstrated robust stability and achieved high encapsulation efficiency. These nanoparticles exhibited significant cytotoxicity compared to the crude drug (p < 0.05) and displayed a promising release pattern consistent with the basic diffusion model. These traits improve the pharmacokinetic profile, efficacy, and ability to precisely target these nanoparticles, offering a potentially successful anticancer treatment for breast cancer. However, additional in vivo assessments of these formulations are obligatory to confirm these findings. Chitosan ; In vivo ; CD44 ; Cytotoxicity ; Drug delivery ; Nanoparticle ; Breast cancer ; Triple-negative breast cancer ; Zeta potential ; Hyaluronic acid ; Chemistry ; Materials science ; Cancer cell ; Pharmacology ; Cancer research ; Nanotechnology ; In vitro ; Cancer ; Medicine ; Biochemistry ; Biology ; Internal medicine Nanoparticle-Based Drug Delivery ; Cancer Treatment and Pharmacology ; HER2/EGFR in Cancer Research
Authors: Afsar Khan | Peiwen Ju | Zhengwei Han | Chenquan Ni
Source: AQUA - Water Infrastructure Ecosystems and Society (review, 2024-02-01)
Field: Chemistry — Organic Chemistry

A comprehensive review on adsorptive removal of azo dyes using functional materials Abstract The shortage of freshwater resources caused by azo dye pollution is an acute global issue, which has a great impact on environmental protection and human health. Therefore, the use of new strategies for designing and synthesizing green, efficient, and economical materials for the removal of azo dyes is required. Among the various methods for removal of azo dyes, adsorption by using advanced functional materials, including nanomaterials, metal oxides, metal oxides–polymer composite, biomaterials, and porous materials, have attracted significant attention over the past few years because of their capabilities of brilliant removal efficiency, high selectivity, quick response, reversibility, flexibility in operation, and less harmful by-products. In this review, we report the adsorption of azo dyes and general design principles underlying the above-mentioned functional materials and, in particular, highlight the fundamental mechanisms and effect of various environmental conditions; also, current challenges and opportunities in this exciting field have been emphasized, including the fabrication, subsequent treatment, and potential future applications of such functional materials. Flexibility (engineering) ; Economic shortage ; Adsorption ; Nanotechnology ; Nanomaterials ; Human health ; Materials science ; Environmental pollution ; Biochemical engineering ; Environmental science ; Chemistry ; Engineering ; Organic chemistry ; Environmental protection Nanomaterials for catalytic reactions ; Adsorption and biosorption for pollutant removal ; Advanced Nanomaterials in Catalysis
Authors: Wim J. Malfait | Hans-Peter Ebert | Samuel Brunner | Jannis Wernery | Sandra Galmarini | Shanyu Zhao | Gudrun Reichenauer
Source: Journal of Sol-Gel Science and Technology (article, 2024-01-03)
Field: Chemistry — Spectroscopy

The poor reliability of thermal conductivity data in the aerogel literature: a call to action! Abstract Aerogels are an exciting class of materials with record-breaking properties including, in some cases, ultra-low thermal conductivities. The last decade has seen a veritable explosion in aerogel research and industry R&amp;D, leading to the synthesis of aerogels from a variety of materials for a rapidly expanding range of applications. However, both from the research side, and certainly from a market perspective, thermal insulation remains the dominant application. Unfortunately, continued progress in this area suffers from the proliferation of incorrect thermal conductivity data, with values that often are far outside of what is possible within the physical limitations. This loss of credibility in reported thermal conductivity data poses difficulties in comparing the thermal performance of different types of aerogels and other thermal superinsulators, may set back further scientific progress, and hinder technology transfer to industry and society. Here, we have compiled 519 thermal conductivity results from 87 research papers, encompassing silica, other inorganic, biopolymer and synthetic polymer aerogels, to highlight the extent of the problem. Thermal conductivity data outside of what is physically possible are common, even in high profile journals and from the world’s best universities and institutes. Both steady-state and transient methods can provide accurate thermal conductivity data with proper instrumentation, suitable sample materials and experienced users, but nearly all implausible data derive from transient methods, and hot disk measurements in particular, indicating that under unfavorable circumstances, and in the context of aerogel research, transient methods are more prone to return unreliable data. Guidelines on how to acquire reliable thermal conductivity data are provided. This paper is a call to authors, reviewers, editors and readers to exercise caution and skepticism when they report, publish or interpret thermal conductivity data. Graphical Abstract Thermal conductivity ; Aerogel ; Transient (computer programming) ; Context (archaeology) ; Materials science ; Computer science ; Nanotechnology ; Mechanical engineering ; Engineering physics ; Engineering ; Composite material ; Geography Aerogels and thermal insulation ; Surface Modification and Superhydrophobicity ; Mesoporous Materials and Catalysis
Authors: Yu Wang | Cheng Bi | Yu Kawamata | Lauren N. Grant | Lacey Samp | Paul Richardson | Shasha Zhang | Kaid C. Harper | Maximilian D. Palkowitz | Aristidis Vasilopoulos | Michael R. Collins | Martins S. Oderinde | Chet C. Tyrol | Doris Chen | Erik LaChapelle | Jake Bailey | Jennifer X. Qiao | Phil S. Baran
Source: Nature Chemistry (article, 2024-05-20)
Field: Chemistry — Organic Chemistry

Discovery of N–X anomeric amides as electrophilic halogenation reagents Halogenation ; Chemistry ; Electrophile ; Reagent ; Amide ; Reactivity (psychology) ; Anomer ; Combinatorial chemistry ; Organic chemistry ; Halogen ; Chemoselectivity ; Lewis acids and bases ; Synthon ; Alkyl ; Catalysis Synthesis and Catalytic Reactions ; Catalytic C–H Functionalization Methods ; Vanadium and Halogenation Chemistry
Authors: Yingjia Liu | Pengfei Li | Rongwei Cui | Chunlian Qin | Linke Wu | Xunzhi Zhang | Bing Li | Jianfeng Ping | Yixian Wang | Jinming Pan | Yibin Ying | Danyang Li | Da Shi | Lizhou Xu
Source: TrAC Trends in Analytical Chemistry (article, 2024-03-30)
Field: Chemistry — Inorganic Chemistry

Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs)-based prototyping of integrated sensing devices for robust analysis Metal-organic framework ; Rapid prototyping ; Covalent bond ; Nanotechnology ; Systems engineering ; Materials science ; Computer science ; Process engineering ; Engineering ; Chemistry ; Organic chemistry Metal-Organic Frameworks: Synthesis and Applications ; Gas Sensing Nanomaterials and Sensors ; Covalent Organic Framework Applications
Authors: Vijayendra Kumar Tripathi | Manish Srivastava | Jaya Dwivedi | Raju Kumar Gupta | Lokesh Kumar Jangir | Kumud Malika Tripathi
Source: Reaction Chemistry & Engineering (article, 2024-01-01)
Field: Materials Science — Materials Chemistry

Biomass-based graphene aerogel for the removal of emerging pollutants from wastewater This review article provides a detailed overview of the synthesis techniques of biomass-based graphene aerogels and highlights the influence of fabrication parameters on the performance of the resulting aerogels for wastewater treatment applications. Aerogel ; Wastewater ; Pollutant ; Biomass (ecology) ; Environmental science ; Graphene ; Waste management ; Environmental chemistry ; Environmental engineering ; Materials science ; Chemistry ; Ecology ; Nanotechnology ; Engineering ; Biology Graphene research and applications ; Graphene and Nanomaterials Applications ; Nanomaterials for catalytic reactions
Authors: Yu Wang | Yangchun Mo | Yingwei Sun | Jing Li | Yu An | Nianping Feng | Ying Liu
Source: Journal of Nanobiotechnology (review, 2024-11-01)
Field: Materials Science — Biomaterials

Intestinal nanoparticle delivery and cellular response: a review of the bidirectional nanoparticle-cell interplay in mucosa based on physiochemical properties Orally administered nanocarriers play an important role in improving druggability, promoting intestinal absorption, and enhancing therapeutic applications for the treatment of local and systemic diseases. However, the delivering efficiency and cell response in mucosa to orally administered nanocarriers is affected by the physiological environment and barriers in the gastrointestinal tract, the physicochemical properties of the nanocarriers, and their bidirectional interactions. Goblet cells secrete and form extracellular mucus, which hinders the movement of nanoparticles. Meanwhile, intestinal epithelial cells may absorb the NPs, allowing for their transcytosis or degradation. Conversely, nanoparticle-induced toxicity may occur as a biological response to the nanoparticle exposure. Additionally, immune response and cell functions in secretions such as mucin, peptide, and cytokines may also be altered. In this review, we discuss the bidirectional interactions between nanoparticles and cells focusing on enterocytes and goblet cells, M cells, and immune cells in the mucosa according to the essential role of intestinal epithelial cells and their crosstalk with immune cells. Furthermore, we discuss the recent advances of how the physiochemical properties of nanoparticles influence their interplay, delivery, and fate in intestinal mucosa. Understanding the fate of nanoparticles with different physiochemical properties from the perspective of their interaction with cells in mucosa provides essential support for the development, rational design, potency maximation, and application of advanced oral nanocarrier delivery systems. Nanoparticle ; Nanotechnology ; Chemistry ; Intestinal mucosa ; Cell biology ; Cell ; Biophysics ; Materials science ; Medicine ; Biology ; Biochemistry ; Internal medicine Nanoparticle-Based Drug Delivery ; Advanced Drug Delivery Systems ; RNA Interference and Gene Delivery
Authors: Tianhao Wu | Hao Jiang | Yujing Zheng | Chunyao Zhao | Keyu Shi | Kangcheng Xu | Xiaodong Li | Meishuai Zou
Source: Advanced Functional Materials (article, 2024-12-05)
Field: Materials Science — Polymers and Plastics

Superior Impact Resistance in Bionic Nanocellulose Composite Supramolecular Elastomers via Multiple Hydrogen Bonding Interactions Abstract Inspired by biological mechanisms of impact protection, nanocellulose and linear polyurethane molecular chains are simultaneously tailored and expanded using supramolecular chemistry. This approach has led to the development of a novel impact protection strategy that leverages multilevel hydrogen bonding interactions. These abundant interactions effectively hinder the crystallization of polycaprolactone (PCL) chain segments, resulting in uniformly distributed microphase separation. This configuration achieves a significant fracture strength of 47.5 MPa, while maintaining an exceptional elongation at a break of 974.2%. The results demonstrate that supramolecular polyurethane‐cellulose nanofiber (SPU‐CNF) elastomer significantly reduces impact force and extends the impact buffer time. Crucially, the underlying mechanisms responsible for energy dissipation and impact protection in SPU‐CNF are elucidated. To validate these properties, impact protection tests at varying impact rates are conducted, underscoring the potential applications of the proposed SPU‐CNF in impact‐resistant materials. Materials science ; Nanocellulose ; Nanofiber ; Elastomer ; Supramolecular chemistry ; Cellulose ; Composite material ; Composite number ; Hydrogen bond ; Bacterial cellulose ; Self-healing ; Polycaprolactone ; Crystallization ; Nanotechnology ; Chemical engineering ; Polymer ; Molecule Polymer composites and self-healing ; Electrospun Nanofibers in Biomedical Applications ; Advanced Cellulose Research Studies
Authors: Martins Taiwo Esan
Source: Discover Civil Engineering (article, 2024-04-16)
Field: Materials Science — Polymers and Plastics

Review of gypsum reinforced composites as building materials Abstract The utilization of gypsum reinforced composites as building materials has garnered considerable attention owing to their exceptional amalgamation of mechanical strength, fire resistance, and versatile applications. This review initiates by introducing gypsum as a pivotal mineral in construction, subsequently exploring the concept of composite materials and elucidating the synergistic effects achieved through reinforcement. Various reinforcement types, such as fibers, polymers, and particles, are meticulously evaluated for their contributions in augmenting mechanical properties, acoustic and thermal insulation, as well as fire resistance in gypsum composites. The review extensively discusses the mechanical attributes of gypsum composites, focusing on compressive strength and flexural behavior enhancements attained through strategic reinforcement methods. Looking ahead, the review emphasizes ongoing research endeavors dedicated to refining material formulations, exploring cutting-edge technologies, and uncovering innovative applications. By addressing challenges and capitalizing on advantages, these composites stand poised to revolutionize conventional building practices, bolster sustainability, and enhance safety and efficiency in built environments. Gypsum ; Reinforcement ; Flexural strength ; Materials science ; Composite material ; Mechanical strength ; Fire resistance ; Compressive strength ; Construction engineering ; Architectural engineering ; Engineering Natural Fiber Reinforced Composites ; Structural Behavior of Reinforced Concrete ; Geotechnical Engineering and Soil Stabilization
Authors: Meryeme El Maouardi | Kris De Braekeleer | Abdelaziz Bouklouze | Yvan Vander Heyden
Source: Food Control (article, 2024-06-22)
Field: Chemistry — Analytical Chemistry

Comparison of Near-Infrared and Mid-Infrared spectroscopy for the identification and quantification of argan oil adulteration through PCA, PLS-DA and PLS Infrared ; Identification (biology) ; Near-infrared spectroscopy ; Infrared spectroscopy ; Chemistry ; Analytical Chemistry (journal) ; Chromatography ; Biology ; Physics ; Botany ; Organic chemistry ; Optics Spectroscopy and Chemometric Analyses ; Edible Oils Quality and Analysis ; Phytochemicals and Antioxidant Activities
Authors: Jie Zhang | Zitao Wang | Jinquan Suo | Chao Tuo | Fengqian Chen | Jianhong Chang | Haorui Zheng | Hui Li | Daliang Zhang | Qianrong Fang | Shilun Qiu
Source: Journal of the American Chemical Society (article, 2024-12-13)
Field: Materials Science — Materials Chemistry

Morphological Tuning of Covalent Organic Framework Single Crystals The synthesis of high-quality single-crystal covalent organic frameworks (COFs) presents significant challenges, particularly in achieving precise control over their morphologies. Herein, we present a straightforward strategy to fine-tune the morphology of COF single crystals. Using rigid triptycene derivatives as the core building blocks and varying the amounts of aniline modulators, we successfully synthesized a series of high-quality COF single crystals with different aspect ratios and well-defined facets, JUC-663-X (X = 30 to 135, the equivalent of aniline). Their structures were characterized using PXRD, TEM, and N<sub>2</sub> adsorption analyses to confirm the structural consistency. The study of the growth mechanism and DFT calculations elucidated the crucial role of aniline as a modulator in facilitating anisotropic competitive binding throughout the crystal growth process. Furthermore, our findings demonstrate that the aspect ratio of these single crystals significantly influences the adsorption properties of Rh B. This research not only paves new paths in the synthesis and morphological control of COF single-crystal materials but also provides profound insights into the relationship between COF morphology and functional performance. Chemistry ; Covalent bond ; Nanotechnology ; Chemical physics ; Crystallography ; Organic chemistry Covalent Organic Framework Applications ; Metal-Organic Frameworks: Synthesis and Applications ; Advanced Photocatalysis Techniques
Authors: Yujia Fan | Tianlei Wang | Rica Asrosa | Bing Li | Nibagani Naresh | Xiaopeng Liu | Shaoliang Guan | Ruixiang Li | Mingqing Wang | Ivan P. Parkin | Buddha Deka Boruah
Source: Chemical Engineering Journal (article, 2024-03-30)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Synergistic contribution of activated carbon and PEDOT:PSS in hybrid electrodes for high-performance planar micro-supercapacitors The high-performance miniaturized micro-supercapacitors exhibit great potential due to their inherent properties of high-power density, fast charge–discharge rates, long cycle life, and wide working temperature range. However, there is a need to further enhance the energy density of micro-supercapacitors. In this study, we investigate a hybrid electrode material combination comprising activated carbon (AC) and polymer poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) to fabricate symmetric micro-supercapacitors (SMSCs) and employ the advanced Microplotter technique for the effective loading of active materials onto microelectrodes. The combination of AC and PEDOT:PSS is fine-tuned to attain optimal charge storage. This involves leveraging the synergistic impact of electrical double-layer capacitance from AC and pseudocapacitance from PEDOT:PSS, resulting in enhanced charge storage performance. Additionally, PEDOT:PSS acts as a mixed ion–electron conducting adhesive, effectively binding AC particles together and facilitating the rapid transport of both ions and electrons. As a result, the AC-PEDOT:PSS SMSCs demonstrate an impressive charge storage performance compared to AC SMSCs. At 1 mA/cm2, the measured areal capacitance (device areal capacitances) is 29.5 mF/cm2 (11.8 mF/cm2) for AC-PEDOT:PSS and 15.7 mF/cm2 (6.3 mF/cm2) for AC SMSCs. Furthermore, the areal energy densities and power densities, considering active materials, are found to be 2.79 µWh/cm2 at 0.8 mW/cm2, and considering the device area of the SMSC, they are 1.12 µWh/cm2 at 0.32 mW/cm2. Notably, the AC-PEDOT:PSS SMSCs exhibit a stable long-term capacitance with 85% capacitance retention even after 5000 cycles. This work highlights the significant potential of hybrid materials in improving energy storage performance and showcases the innovative application of the Microplotter technique. Supercapacitor ; PEDOT:PSS ; Activated carbon ; Materials science ; Planar ; Electrode ; Nanotechnology ; Chemical engineering ; Capacitance ; Chemistry ; Computer science ; Engineering ; Layer (electronics) ; Organic chemistry Supercapacitor Materials and Fabrication ; Advanced Sensor and Energy Harvesting Materials ; Conducting polymers and applications
Authors: Diab Khalafallah | Nura Ibrahim | Lawal Mohammed | Qinfang Zhang
Source: Carbon (article, 2024-10-12)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Z-scheme heterostructures confining rGO/protonated C3N5 junction supported CoCu LDH positive electrode and Fe3O4 negative electrode for supercapacitors Electrode ; Supercapacitor ; Heterojunction ; Materials science ; Chemical engineering ; Nanotechnology ; Optoelectronics ; Electrochemistry ; Chemistry ; Engineering Supercapacitor Materials and Fabrication ; Advancements in Battery Materials ; MXene and MAX Phase Materials
Authors: Philipp H. Kirchner | L. Schramm | Svetlana Ivanova | Kazutaka Shoyama | Frank Würthner | Florian Beuerle
Source: Journal of the American Chemical Society (article, 2024-02-07)
Field: Materials Science — Materials Chemistry

A Water-Stable Boronate Ester Cage The reversible condensation of catechols and boronic acids to boronate esters is a paradigm reaction in dynamic covalent chemistry. However, facile backward hydrolysis is detrimental for stability and has so far prevented applications for boronate-based materials. Here, we introduce cubic boronate ester cages <b>6</b> derived from hexahydroxy tribenzotriquinacenes and phenylene diboronic acids with <i>ortho</i>-<i>t</i>-butyl substituents. Due to steric shielding, dynamic exchange at the Lewis acidic boron sites is feasible only under acid or base catalysis but fully prevented at neutral conditions. For the first time, boronate ester cages <b>6</b> tolerate substantial amounts of water or alcohols both in solution and solid state. The unprecedented applicability of these materials under ambient and aqueous conditions is showcased by efficient encapsulation and on-demand release of β-carotene dyes and heterogeneous water oxidation catalysis after the encapsulation of ruthenium catalysts. Chemistry ; Catalysis ; Aqueous solution ; Ruthenium ; Boronic acid ; Borylation ; Steric effects ; Hydrolysis ; Covalent bond ; Lewis acids and bases ; Combinatorial chemistry ; Heterogeneous catalysis ; Organic chemistry ; Polymer chemistry ; Aryl Covalent Organic Framework Applications ; Organoboron and organosilicon chemistry ; Luminescence and Fluorescent Materials