jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Ying Lv | Wenqing Li | Wei Liao | Haibo Jiang | Yuwei Liu | Jiansheng Cao | Wenfei Lu | Yufei Feng
Source: International Journal of Nanomedicine (review, 2024-01-01)
Field: Materials Science — Biomaterials

Nano-Drug Delivery Systems Based on Natural Products Natural products have proven to have significant curative effects and are increasingly considered as potential candidates for clinical prevention, diagnosis, and treatment. Compared with synthetic drugs, natural products not only have diverse structures but also exhibit a range of biological activities against different disease states and molecular targets, making them attractive for development in the field of medicine. Despite advancements in the use of natural products for clinical purposes, there remain obstacles that hinder their full potential. These challenges include issues such as limited solubility and stability when administered orally, as well as short durations of effectiveness. To address these concerns, nano-drug delivery systems have emerged as a promising solution to overcome the barriers faced in the clinical application of natural products. These systems offer notable advantages, such as a large specific surface area, enhanced targeting capabilities, and the ability to achieve sustained and controlled release. Extensive in vitro and in vivo studies have provided further evidence supporting the efficacy and safety of nanoparticle-based systems in delivering natural products in preclinical disease models. This review describes the limitations of natural product applications and the current status of natural products combined with nanotechnology. The latest advances in nano-drug delivery systems for delivery of natural products are considered from three aspects: connecting targeting warheads, self-assembly, and co-delivery. Finally, the challenges faced in the clinical translation of nano-drugs are discussed. Drug delivery ; Nano- ; Materials science ; Nanotechnology ; Drug ; Medicine ; Pharmacology ; Composite material Supramolecular Self-Assembly in Materials ; RNA Interference and Gene Delivery ; Curcumin's Biomedical Applications
Authors: Ivan V. Zelepukin | Konstantin G. Shevchenko | Sergey M. Deyev
Source: Nature Communications (article, 2024-05-22)
Field: Materials Science — Biomaterials

Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery Rapid uptake of nanoparticles by mononuclear phagocyte system (MPS) significantly hampers their therapeutic efficacy. Temporal MPS blockade is one of the few ways to overcome this barrier - the approach rediscovered many times under different names but never extensively used in clinic. Using meta-analysis of the published data we prove the efficacy of this technique for enhancing particle circulation in blood and their delivery to tumours, describe a century of its evolution and potential combined mechanism behind it. Finally, we discuss future directions of the research focusing on the features essential for successful clinical translation of the method. Mononuclear phagocyte system ; Drug delivery ; Blockade ; Phagocyte ; Medicine ; Drug ; Peripheral blood mononuclear cell ; Translation (biology) ; Computer science ; Computational biology ; Immunology ; Pharmacology ; Phagocytosis ; Chemistry ; Biology ; Nanotechnology ; Receptor ; Materials science ; Internal medicine ; Biochemistry Nanoparticle-Based Drug Delivery ; Phagocytosis and Immune Regulation ; Erythrocyte Function and Pathophysiology
Authors: Huazhang Guo | Yuhao Lu | Zhendong Lei | Hong Bao | Mingwan Zhang | Zeming Wang | Cuntai Guan | Bijun Tang | Zheng Liu | Liang Wang
Source: Nature Communications (article, 2024-06-06)
Field: Materials Science — Materials Chemistry

Machine learning-guided realization of full-color high-quantum-yield carbon quantum dots Carbon quantum dots (CQDs) have versatile applications in luminescence, whereas identifying optimal synthesis conditions has been challenging due to numerous synthesis parameters and multiple desired outcomes, creating an enormous search space. In this study, we present a novel multi-objective optimization strategy utilizing a machine learning (ML) algorithm to intelligently guide the hydrothermal synthesis of CQDs. Our closed-loop approach learns from limited and sparse data, greatly reducing the research cycle and surpassing traditional trial-and-error methods. Moreover, it also reveals the intricate links between synthesis parameters and target properties and unifies the objective function to optimize multiple desired properties like full-color photoluminescence (PL) wavelength and high PL quantum yields (PLQY). With only 63 experiments, we achieve the synthesis of full-color fluorescent CQDs with high PLQY exceeding 60% across all colors. Our study represents a significant advancement in ML-guided CQDs synthesis, setting the stage for developing new materials with multiple desired properties. Quantum yield ; Computer science ; Photoluminescence ; Quantum dot ; Carbon quantum dots ; Quantum ; Realization (probability) ; Fluorescence ; Carbon fibers ; Materials science ; Function (biology) ; Nanotechnology ; Algorithm ; Optoelectronics ; Mathematics ; Physics ; Optics Carbon and Quantum Dots Applications ; Quantum Dots Synthesis And Properties ; Nanocluster Synthesis and Applications
Authors: Μaria-Anna Gatou | Eirini Skylla | Panagiota Dourou | Νatassa Pippa | Maria Gazouli | Nefeli Lаgopati | Evangelia A. Pavlatou
Source: Crystals (article, 2024-02-23)
Field: Materials Science — Materials Chemistry

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications In recent times, there has been considerable interest among researchers in magnesium oxide (MgO) nanoparticles, due to their excellent biocompatibility, stability, and diverse biomedical uses, such as antimicrobial, antioxidant, anticancer, and antidiabetic properties, as well as tissue engineering, bioimaging, and drug delivery applications. Consequently, the escalating utilization of magnesium oxide nanoparticles in medical contexts necessitates the in-depth exploration of these nanoparticles. Notably, existing literature lacks a comprehensive review of magnesium oxide nanoparticles’ synthesis methods, detailed biomedical applications with mechanisms, and toxicity assessments. Thus, this review aims to bridge this gap by furnishing a comprehensive insight into various synthetic approaches for the development of MgO nanoparticles. Additionally, it elucidates their noteworthy biomedical applications as well as their potential mechanisms of action, alongside summarizing their toxicity profiles. This article also highlights challenges and future prospects for further exploring MgO nanoparticles in the biomedical field. Existing literature indicates that synthesized magnesium oxide nanoparticles demonstrate substantial biocompatibility and display significant antibacterial, antifungal, anticancer, and antioxidant properties. Consequently, this review intends to enhance readers’ comprehension regarding recent advancements in synthesizing MgO nanoparticles through diverse approaches and their promising applications in biomedicine. Biocompatibility ; Nanotechnology ; Nanoparticle ; Magnesium ; Materials science ; Drug delivery ; Biomedicine ; Bioinformatics ; Biology ; Metallurgy Magnesium Oxide Properties and Applications ; Nanoparticles: synthesis and applications ; Bone Tissue Engineering Materials
Authors: Maki Nakatani | Satoru Fukamachi | Pablo Solís‐Fernández | Satoshi Honda | Kenji Kawahara | Yuta Tsuji | Yosuke Sumiya | Mai Kuroki | Kou Li | Qiunan Liu | Yung‐Chang Lin | Aika Uchida | S. Oyama | Hyun Goo Ji | Kenichi Okada | Kazu Suenaga | Yukio Kawano | Kazunari Yoshizawa | Atsushi Yasui | Hiroki Ago
Source: Nature Electronics (article, 2024-02-09)
Field: Materials Science — Materials Chemistry

Ready-to-transfer two-dimensional materials using tunable adhesive force tapes Abstract Graphene and other two-dimensional (2D) materials can be used to create electronic and optoelectronic devices. However, their development has been limited by the lack of effective large-area transfer processes. Here we report a transfer method that uses functional tapes with adhesive forces controlled by ultraviolet light. The adhesion of the tape is optimized for the transfer of monolayer graphene, providing a yield of over 99%. Once detached from the growth substrate, the graphene/tape stack enables easy transfer of graphene to the desired target substrate. The method can be used to transfer other 2D materials, including bilayer graphene, transition metal dichalcogenides, hexagonal boron nitride and stacked heterostructures. The solvent-free nature of the final release step facilitates transfer to various target substrates including flexible polymers, paper and three-dimensional surfaces. The tape/2D material stacks can also be cut into desired sizes and shapes, allowing site-selective device fabrication with reduced loss of 2D materials. Graphene ; Materials science ; Transfer printing ; Adhesive ; Monolayer ; Substrate (aquarium) ; Fabrication ; Heterojunction ; Nanotechnology ; Hexagonal boron nitride ; Bilayer ; Optoelectronics ; Stack (abstract data type) ; Boron nitride ; Polymer ; Composite material ; Layer (electronics) ; Membrane ; Computer science Graphene research and applications ; Advanced Sensor and Energy Harvesting Materials ; 2D Materials and Applications
Authors: Na Qu | Ke Song | Yating Ji | Mingxia Liu | Lijiang Chen | Robert Lee | Lesheng Teng
Source: International Journal of Nanomedicine (review, 2024-07-01)
Field: Materials Science — Biomaterials

Albumin Nanoparticle-Based Drug Delivery Systems Nanoparticle-based systems are extensively investigated for drug delivery. Among others, with superior biocompatibility and enhanced targeting capacity, albumin appears to be a promising carrier for drug delivery. Albumin nanoparticles are highly favored in many disease therapies, as they have the proper chemical groups for modification, cell-binding sites for cell adhesion, and affinity to protein drugs for nanocomplex generation. Herein, this review summarizes the recent fabrication techniques, modification strategies, and application of albumin nanoparticles. We first discuss various albumin nanoparticle fabrication methods, from both pros and cons. Then, we provide a comprehensive introduction to the modification section, including organic albumin nanoparticles, metal albumin nanoparticles, inorganic albumin nanoparticles, and albumin nanoparticle-based hybrids. We finally bring further perspectives on albumin nanoparticles used for various critical diseases. Drug delivery ; Nanoparticle ; Drug ; Materials science ; Nanotechnology ; Drug carrier ; Albumin ; Medicine ; Pharmacology ; Internal medicine Nanoparticle-Based Drug Delivery ; Advanced Drug Delivery Systems ; Advancements in Transdermal Drug Delivery
Authors: Swarn Jha | Bhargav Akula | Hannah Enyioma | M. Novák | Vansh Amin | Hong Liang
Source: Polymers (review, 2024-08-09)
Field: Materials Science — Biomaterials

Biodegradable Biobased Polymers: A Review of the State of the Art, Challenges, and Future Directions Biodegradable biobased polymers derived from biomass (such as plant, animal, marine, or forestry material) show promise in replacing conventional petrochemical polymers. Research and development have been conducted for decades on potential biodegradable biobased polymers such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), and succinate polymers. These materials have been evaluated for practicality, cost, and production capabilities as limiting factors in commercialization; however, challenges, such as the environmental limitations on the biodegradation rates for biodegradable biobased polymer, need to be addressed. This review provides a history and overview of the current development in the synthesis process and properties of biodegradable biobased polymers, along with a techno-commercial analysis and discussion on the environmental impacts of biodegradable biobased polymers. Specifically, the techno-commercial analysis focuses on the commercial potential, financial assessment, and life-cycle assessment of these materials, as well as government initiatives to facilitate the transition towards biodegradable biobased polymers. Lastly, the environmental assessment focuses on the current challenges with biodegradation and methods of improving the recycling process and reusability of biodegradable biobased polymers. Polyhydroxyalkanoates ; Biodegradable polymer ; Biodegradation ; Polylactic acid ; Bioplastic ; Materials science ; Polymer ; Petrochemical ; Environmentally friendly ; Biodegradable plastic ; Biochemical engineering ; Waste management ; Organic chemistry ; Engineering ; Chemistry ; Ecology biodegradable polymer synthesis and properties ; Microplastics and Plastic Pollution ; Carbon dioxide utilization in catalysis
Authors: Linfeng Pan | Linjie Dai | Oliver J. Burton | Lu Chen | Virgil Andrei | Youcheng Zhang | Dan Ren | Jinshui Cheng | Linxiao Wu | Kyle Frohna | Anna Abfalterer | Terry Chien‐Jen Yang | Wenzhe Niu | Meng Xia | Stephan Hofmann | Paul J. Dyson | Erwin Reisner | Henning Sirringhaus | Jingshan Luo | Anders Hagfeldt | Michaël Grätzel | Samuel D. Stranks
Source: Nature (article, 2024-04-24)
Field: Materials Science — Materials Chemistry

High carrier mobility along the [111] orientation in Cu2O photoelectrodes Solar fuels offer a promising approach to provide sustainable fuels by harnessing sunlight<sup>1,2</sup>. Following a decade of advancement, Cu<sub>2</sub>O photocathodes are capable of delivering a performance comparable to that of photoelectrodes with established photovoltaic materials<sup>3-5</sup>. However, considerable bulk charge carrier recombination that is poorly understood still limits further advances in performance<sup>6</sup>. Here we demonstrate performance of Cu<sub>2</sub>O photocathodes beyond the state-of-the-art by exploiting a new conceptual understanding of carrier recombination and transport in single-crystal Cu<sub>2</sub>O thin films. Using ambient liquid-phase epitaxy, we present a new method to grow single-crystal Cu<sub>2</sub>O samples with three crystal orientations. Broadband femtosecond transient reflection spectroscopy measurements were used to quantify anisotropic optoelectronic properties, through which the carrier mobility along the [111] direction was found to be an order of magnitude higher than those along other orientations. Driven by these findings, we developed a polycrystalline Cu<sub>2</sub>O photocathode with an extraordinarily pure (111) orientation and (111) terminating facets using a simple and low-cost method, which delivers 7 mA cm<sup>-2</sup> current density (more than 70% improvement compared to that of state-of-the-art electrodeposited devices) at 0.5 V versus a reversible hydrogen electrode under air mass 1.5 G illumination, and stable operation over at least 120 h. Photocathode ; Materials science ; Optoelectronics ; Charge carrier ; Anisotropy ; Heterojunction ; Photovoltaics ; Electron mobility ; Crystal (programming language) ; Crystallite ; Carrier lifetime ; Single crystal ; Femtosecond ; Optics ; Photovoltaic system ; Chemistry ; Laser ; Crystallography ; Physics Copper-based nanomaterials and applications ; Electronic and Structural Properties of Oxides ; ZnO doping and properties
Authors: Sebastian B. Beil | Sylvestre Bonnet | Carla Casadevall | Remko J. Detz | Fabian Eisenreich | Starla D. Glover | Christoph Kerzig | Line Næsborg | Sonja Pullen | Golo Storch | Ning Wei | Cathleen Zeymer
Source: JACS Au (review, 2024-08-08)
Field: Chemistry — Organic Chemistry

Challenges and Future Perspectives in Photocatalysis: Conclusions from an Interdisciplinary Workshop Photocatalysis is a versatile and rapidly developing field with applications spanning artificial photosynthesis, photo-biocatalysis, photoredox catalysis in solution or supramolecular structures, utilization of abundant metals and organocatalysts, sustainable synthesis, and plastic degradation. In this Perspective, we summarize conclusions from an interdisciplinary workshop of young principal investigators held at the Lorentz Center in Leiden in March 2023. We explore how diverse fields within photocatalysis can benefit from one another. We delve into the intricate interplay between these subdisciplines, by highlighting the unique challenges and opportunities presented by each field and how a multidisciplinary approach can drive innovation and lead to sustainable solutions for the future. Advanced collaboration and knowledge exchange across these domains can further enhance the potential of photocatalysis. Artificial photosynthesis has become a promising technology for solar fuel generation, for instance, via water splitting or CO<sub>2</sub> reduction, while photocatalysis has revolutionized the way we think about assembling molecular building blocks. Merging such powerful disciplines may give rise to efficient and sustainable protocols across different technologies. While photocatalysis has matured and can be applied in industrial processes, a deeper understanding of complex mechanisms is of great importance to improve reaction quantum yields and to sustain continuous development. Photocatalysis is in the perfect position to play an important role in the synthesis, deconstruction, and reuse of molecules and materials impacting a sustainable future. To exploit the full potential of photocatalysis, a fundamental understanding of underlying processes within different subfields is necessary to close the cycle of use and reuse most efficiently. Following the initial interactions at the Lorentz Center Workshop in 2023, we aim to stimulate discussions and interdisciplinary approaches to tackle these challenges in diverse future teams. Photocatalysis ; Engineering ethics ; Political science ; Psychology ; Engineering ; Chemistry Radical Photochemical Reactions ; Advanced Photocatalysis Techniques ; Sulfur-Based Synthesis Techniques
Authors: Jieyu Yue | Jing‐Xian Luo | Zi‐Xian Pan | Ruizhi Zhang | Peng Yang | Qing Xu | Bo Tang
Source: Angewandte Chemie International Edition (article, 2024-04-12)
Field: Materials Science — Materials Chemistry

Regulating the Topology of Covalent Organic Frameworks for Boosting Overall H<sub>2</sub>O<sub>2</sub> Photogeneration Photocatalytic oxygen reduction reactions and water oxidation reactions are extremely promising green approaches for massive H<sub>2</sub>O<sub>2</sub> production. Nonetheless, constructing effective photocatalysts for H<sub>2</sub>O<sub>2</sub> generation is critical and still challenging. Since the network topology has significant impacts on the electronic properties of two dimensional (2D) polymers, herein, for the first time, we regulated the H<sub>2</sub>O<sub>2</sub> photosynthetic activity of 2D covalent organic frameworks (COFs) by topology. Through designing the linking sites of the monomers, we synthesized a pair of novel COFs with similar chemical components on the backbones but distinct topologies. Without sacrificial agents, TBD-COF with cpt topology exhibited superior H<sub>2</sub>O<sub>2</sub> photoproduction performance (6085 and 5448 μmol g<sup>-1</sup> h<sup>-1</sup> in O<sub>2</sub> and air) than TBC-COF with hcb topology through the O<sub>2</sub>-O<sub>2</sub>⋅<sup>-</sup>-H<sub>2</sub>O<sub>2</sub>, O<sub>2</sub>-O<sub>2</sub>⋅<sup>-</sup>-O<sub>2</sub> <sup>1</sup>-H<sub>2</sub>O<sub>2</sub>, and H<sub>2</sub>O-H<sub>2</sub>O<sub>2</sub> three paths. Further experimental and theoretical investigations confirmed that during the H<sub>2</sub>O<sub>2</sub> photosynthetic process, the charge carrier separation efficiency, O<sub>2</sub>⋅<sup>-</sup> generation and conversion, and the energy barrier of the rate determination steps in the three channels, related to the formation of *OOH, *O<sub>2</sub> <sup>1</sup>, and *OH, can be well tuned by the topology of COFs. The current study enlightens the fabrication of high-performance photocatalysts for H<sub>2</sub>O<sub>2</sub> production by topological structure modulation. Boosting (machine learning) ; Covalent bond ; Photochemistry ; Chemistry ; Topology (electrical circuits) ; Materials science ; Organic chemistry ; Computer science ; Engineering ; Artificial intelligence Covalent Organic Framework Applications ; Advanced Photocatalysis Techniques ; Metal-Organic Frameworks: Synthesis and Applications
Authors: Yue Zhuo | Yong‐Gang Zhao | Yun Zhang
Source: Molecules (review, 2024-10-13)
Field: Materials Science — Biomaterials

Enhancing Drug Solubility, Bioavailability, and Targeted Therapeutic Applications through Magnetic Nanoparticles Biological variability poses significant challenges in the development of effective therapeutics, particularly when it comes to drug solubility and bioavailability. Poor solubility across varying physiological conditions often leads to reduced absorption and inconsistent therapeutic outcomes. This review examines how nanotechnology, especially through the use of nanomaterials and magnetic nanoparticles, offers innovative solutions to enhance drug solubility and bioavailability. This comprehensive review focuses on recent advancements and approaches in nanotechnology. We highlight both the successes and remaining challenges in this field, emphasizing the role of continued innovation. Future research should prioritize developing universal therapeutic solutions, conducting interdisciplinary research, and leveraging personalized nanomedicine to address biological variability. Bioavailability ; Nanomedicine ; Nanotechnology ; Drug ; Solubility ; Biochemical engineering ; Nanoparticle ; Pharmacology ; Materials science ; Medicine ; Chemistry ; Engineering Nanoparticle-Based Drug Delivery ; Nanomaterials for catalytic reactions ; Graphene and Nanomaterials Applications
Authors: Amir Farokh Payam | Sameh Khalil | Supriya Chakrabarti
Source: Small (review, 2024-04-25)
Field: Chemistry — Inorganic Chemistry

Synthesis and Characterization of MOF‐Derived Structures: Recent Advances and Future Perspectives Due to their facile tunability, metal-organic frameworks (MOFs) are employed as precursors and templates to construct advanced functional materials with unique and desired chemical, physical, mechanical, and morphological properties. By tuning MOF precursor composition and manipulating conversion processes, various MOF-derived materials commonly known as MOF derivatives can be constructed. The possibility of controlled and predictable properties makes MOF derivatives a preferred choice for numerous advanced technological applications. The innovative synthetic designs besides the plethora of interdisciplinary characterization approaches applicable to MOF derivatives provide the opportunity to perform a myriad of experiments to explore the performance and offer key insight to develop the next generation of advanced materials. Though there are many published works of literature describing various synthesis and characterization techniques of MOF derivatives, it is still not clear how the synthesis mechanism works and what are the best techniques to characterize these materials to probe their properties accurately. In this review, the recent development in synthesis techniques and mechanisms for a variety of MOF derivates such as MOF-derived metal oxides, porous carbon, composites/hybrids, and sulfides is summarized. Furthermore, the details of characterization techniques and fundamental working principles are summarized to probe the structural, mechanical, physiochemical, electrochemical, and electronic properties of MOF and MOF derivatives. The future trends and some remaining challenges in the synthesis and characterization of MOF derivatives are also discussed. Characterization (materials science) ; Nanotechnology ; Materials science Metal-Organic Frameworks: Synthesis and Applications ; Machine Learning in Materials Science ; Gas Sensing Nanomaterials and Sensors