jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Danielle Teixeira Freire | Júlio Abreu Miranda | Douglas Dourado | Éverton do Nascimento Alencar
Source: Journal of Nanotheranostics (article, 2025-04-09)
Field: Materials Science — Biomaterials

Evolution of Theranostic Nanoparticles Through the Lens of Patents Theranostic nanoparticles integrate diagnostic and therapeutic potential, representing a promising approach in precision medicine. Accordingly, numerous inventions have been patented to protect novel formulations and methods. This review examines the evolution of patented theranostic nanoparticles, focusing on organic nanosystems, particularly polymeric and lipid nanoparticles, to assess their development, technological advances, and patentability. A scoping review approach was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines in the World Intellectual Property Organization (WIPO) and European Patent Office (EPO) database. The search included patents filed within the last ten years (2014–2024) that specifically claimed organic and/or hybrid theranostic nanoparticles. Data extraction focused on nanoparticle composition, synthesis methods, functionalization strategies, and theranostic applications. The search identified 130 patents, of which 13 met the inclusion criteria. These patents were primarily filed by inventors from the United States, Canada, Great Britain, Italy, and China. Polymeric nanoparticles were frequently engineered for targeted drug delivery and imaging, utilizing hyperbranched polyesters, sulfated polymers, or chitosan-based formulations. Lipid nanoparticles were often hybridized with inorganic nanomaterials or magnetic nanostructures to enhance their theranostic potential. While most patents detailed synthesis methods and physicochemical characterizations, only a few provided comprehensive preclinical validation, limiting their demonstrated efficacy. The analysis of recent patents highlights significant advances in the design and application of theranostic nanoparticles. However, a notable gap remains in validating these nanosystems for clinical translation. Future efforts should emphasize robust preclinical data, including in vitro and in vivo assessments, to enhance patent quality and applicability to substantiate the claimed theranostic capabilities. Lens (geology) ; Nanoparticle ; Nanotechnology ; Materials science ; Optics ; Physics Nanoparticle-Based Drug Delivery ; Gold and Silver Nanoparticles Synthesis and Applications ; Advanced Nanomaterials in Catalysis
Authors: Deepak Kakde | Banaz Fetah | Suse S. Bebiano | Martin R. Ward | C.L. Doherty | Daniel Markl | Iain D. H. Oswald
Source: International Journal of Pharmaceutics (article, 2025-05-14)
Field: Chemistry — Spectroscopy

Real-time polymorphic form assessment of pharmaceuticals at tabletting pressures using micro-scale quantities Assessing polymorphic form changes in active pharmaceutical ingredients (APIs) during the early stage is critical for selecting the best polymorphic form required for drug product development. However, this assessment can be constrained by limited API availability. Present methods to assess risk in industry relies on larger volume equipment such as a compaction simulator or texture analyser (TA) that requires larger quantities of API. In the present study, a diamond anvil cell (DAC) was used, that reduces the quantity of material even further to micrograms to investigate the impact of pressure using Hydrochlorothiazide (HCT) as a model API. The powdered API was directly loaded into the DAC sample chamber without a pressure-transmitting medium (PTM), and Raman spectroscopy was used to monitor form changes. A polymorphic transition begins to be observed at 300 MPa pressure in the DAC that is commensurate with the findings in the TA (500 MPa) from Raman and X-ray powder diffraction (XRPD). XRPD analysis revealed that trituration likely causes a transformation back to the original phase as undisturbed samples can be stored for months. In conclusion, the study highlights the effectiveness of the DAC as a material sparing technique for assessing pressure induced polymorphic transition in APIs at the time of compression enabling a real-time monitoring of the process. The DAC successfully detected the polymorphic transition in tabletting compression range requiring significantly less material than the TA. The minimal consumption of API making DAC a preferred method for polymorphic screening particularly at the early stage of development when material availability is limited. Scale (ratio) ; Pharmaceutical technology ; Environmental science ; Chromatography ; Chemistry ; Mineralogy ; Materials science ; Physics Analytical Chemistry and Chromatography ; Crystallization and Solubility Studies ; Protein purification and stability
Authors: Atheer Alnassir | Fatima Albinali | Fatimah Aljaroudi | Nouf Alsaleem | Shafiqur Rehman
Source: FME Transaction (article, 2025-01-01)
Field: Materials Science — General Materials Science

A comprehensive review of existing erosion protective coatings and practices for wind turbine blade surfaces Wind turbine blades (WTBs) are constantly exposed to extreme environmental exposures such as rain, sand, UV radiation, humidity, thermal cycling, and icing, all of which impact their structural integrity as well as efficiency. Polymer-based protective coatings such as polyethylene oxide (PEO), polyurethane (PU), polyvinylpyrrolidone (PVP), and polyvinyl alcohol (PVA) are promising options due to their flexibilities, cost-effectiveness, and tunability. This review analyzes 80 laboratory studies on development and application of such coatings, using nanofillers and hybrid composites for performance enhancement. Spray coating, dip coating, electrospinning, and spin coating techniques are evaluated by erosion resistance, UV degradation, icing, and water vapor. Latest advances in self-healing and smart coatings are highlighted. Although promising laboratory results, long-term performance and environmental survivability under real-world conditions are not well understood. The research goals to establish the gaps in research and offer inputs on creating sustainable, multi-functional coatings for prolonging the working life of wind turbine blades. Blade (archaeology) ; Turbine blade ; Turbine ; Erosion ; Aeolian processes ; Marine engineering ; Engineering ; Materials science ; Environmental science ; Aerospace engineering ; Mechanical engineering ; Geology Material Properties and Applications ; Erosion and Abrasive Machining ; Coal Combustion and Slurry Processing
Authors: Henrik Siegel | Martin F. Haase
Source: Small (article, 2025-07-16)
Field: Materials Science — Materials Chemistry

Bijel Membranes with Tunable Porosity for pH‐responsive Microfiltration Bicontinuous interfacially jammed emulsion gels (bijels) are nanoparticle-stabilized composite materials with significant potential in membrane separations. This work introduces the fabrication of bijel sheets with symmetric pore structures and demonstrates their use as pH-responsive microfiltration membranes. Unlike established hollow fiber-bijel membranes, symmetric bijel sheets offer a more scalable and robust production route of separation membranes via roll-to-roll solvent transfer induced phase separation (R2R-STrIPS). The role of substrate wetting by the liquid bijel precursor in determining membrane structure is analyzed. Pore sizes are tuned by varying the surfactant concentration in the precursor solution. In contrast to existing bijel membranes that rely on rigid polymer scaffolds - resulting in brittleness and limited control over separation properties, stimuli-responsive polymers are employed to create soft, adaptable bijels. This pH-responsiveness enables dynamic control over membrane permeability, including feed-stream-driven compaction and tunable performance via polymer cross-linking. These functional characteristics expand the potential applications of symmetric bijel sheets to drug delivery, controlled release, and soft robotics. Membrane ; Materials science ; Microfiltration ; Chemical engineering ; Polymer ; Emulsion ; Synthetic membrane ; Porosity ; Phase inversion ; Soft robotics ; Nanotechnology ; Composite material ; Chemistry ; Actuator Pickering emulsions and particle stabilization ; Membrane Separation Technologies ; Hydrogels: synthesis, properties, applications
Authors: Servet Ozdemir | Matthew Rogers | Zabeada Aslam | M. Ali | Gilberto Teobaldi | Timothy Moorsom | B. J. Hickey | Oscar Céspedes
Source: Nano Letters (article, 2025-08-20)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Acceptor–Donor Molecular Heterojunction Control of π-Orbital-Induced Magnetic Properties of a 3d Ferromagnet Metal-organic molecule interfaces have given rise to a wide range of magnetic phenomena. These effects arise due to spin-polarized charge transfer and enhanced exchange interaction at metallo-molecular hybridization sites, where tunability via electric fields beyond ferroelectric interfaces remains to be demonstrated. Here, we explore manipulating the magnetism of cobalt with the intrinsic electric field generated at C<sub>60</sub>/phthalocyanine heterojunctions, a combination commonly used in organic photovoltaics. The results give evidence for a C<sub>60</sub> layer thickness-dependent control of hybridization effects on cobalt. We find that the heterojunctions may attenuate the hybridization effects, with changes in coercivity and magnetization due to the built-in electric field. An emergent exchange bias is attributed to an enhanced Rashba interaction for thicker C<sub>60</sub> layers. Our study clarifies some of the questions in the field of molecular "spinterface" physics and demonstrates that internal electric field generation is a promising method for manipulation of metallo-molecular interfaces up to room temperature. Ferromagnetism ; Heterojunction ; Acceptor ; Materials science ; Molecular orbital ; Condensed matter physics ; Chemistry ; Optoelectronics ; Physics ; Molecule Magnetism in coordination complexes ; Organic and Molecular Conductors Research ; Porphyrin and Phthalocyanine Chemistry
Authors: W. Chan | Tafadzwa Kaseke | Sook Chin Chew | Yun Ping Neo | Kar Lin Nyam
Source: Frontiers in Food Science and Technology (article, 2025-12-05)
Field: Materials Science — Biomaterials

Recent advances in active, smart and edible packaging applications to enhance post-harvest quality and shelf-life of fruits Post-harvest fruit losses result in significant waste problem due to the decline in quality by physiological metabolism and unfavorable environmental conditions. To extend shelf life and mitigate waste and environmental impacts, investigations on innovative fruit packaging technologies such as active, edible, biodegradable, and smart packaging are warranted. Active packaging enhances fruit preservation by ethylene scavengers, controlling fungal growth, regulating moisture, and providing antioxidants through bioactive compounds. A growing trend involves edible and biodegradable packaging made from natural polymers (polysaccharides, proteins, and lipids), which prevents physical, mechanical, and microbiological damage to fruits while also serving as a medium for additives like antimicrobials and antioxidants, thus improving freshness and quality. In addition, smart packaging utilizes biosensors, pH indicators, and gas indicators for live monitoring throughout the supply chain and can be united with other packaging technologies to enhance functionality. Current developments concern on the green and hybrid packaging, particularly to unite biodegradable packaging with active and smart packaging to deliver synergistic functionalities. This can preserve the fruits quality while offering active properties or live monitoring while supporting environmental sustainability. This review provides insights on the current advances and potential future development in innovative active, edible, biodegradable, and smart packaging technologies, while also addressing the current challenges associated with these packaging. Active packaging ; Shelf life ; Quality (philosophy) ; Supply chain ; Food packaging ; Plastic packaging Nanocomposite Films for Food Packaging ; Postharvest Quality and Shelf Life Management ; Advanced Cellulose Research Studies
Authors: Yin Qian | Yan Gao | Lei Xu | Reinhard K. Kremer | Jin Zhang | Xiao‐Ming Ren
Source: Magnetochemistry (article, 2025-01-24)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Comprehensively Understanding the Transformation of Paramagnetic Tetramer to Spin-Paired Dimer in an S = ½ Molecular Crystal In this study, we comparatively analyzed the variable-temperature crystal structures for two isomorphous salts, [1-benzyl-4-aminopyridinium][M(mnt)2] (M = Ni or Cu; mnt2− = maleonitriledithiolate; labeled as APy-Ni or APy-Cu). Both salts crystallize in the triclinic P–1 space group at 296 K, comprising linear [M(mnt)2]− (M = Ni or Cu) tetramers. A magnetostructural phase transition occurs at TC~190 K in S = ½ APy-Ni at ambient pressure, with a conversion of paramagnetic tetramers into nonmagnetic spin-paired dimers. The discontinuous alteration of cell parameters at TC signifies the characteristic of first-order phase transition in APy-Ni. No such transition appears in the nonmagnetic APy-Cu within the same temperature vicinity, demonstrating the magnetic interactions promoting the structural phase transition in APy-Ni, which is further reinforced through a comparison of the lattice formation energy between APy-Ni and APy-Cu. The phase transition may bear a resemblance to the mechanisms typically observed in spin-Peierls systems. We further explored the magnetic and phase transition properties of APy-Ni under varying pressures. Significantly, TC shows a linear increase with rising pressure within the range of 0.003–0.88 GPa, with a rate of 90 K GPa−1, manifesting that the applied pressure promotes the transition from tetramer to dimer. Tetramer ; Paramagnetism ; Dimer ; Spin (aerodynamics) ; Condensed matter physics ; Transformation (genetics) ; Crystal (programming language) ; Materials science ; Chemical physics ; Chemistry ; Crystallography ; Physics ; Nuclear magnetic resonance ; Computer science Magnetism in coordination complexes ; Advanced NMR Techniques and Applications ; Organic and Molecular Conductors Research
Authors: Tiba Al Temimi | Huda Mohammed Reda | Reda Elfeshawy | Amal Talib Al Sa'ady | Shatha Khazal K. Hindi
Source: Trends in Pharmaceutical Biotechnology (article, 2025-06-30)
Field: Materials Science — Biomaterials

Nanocarriers in Targeted Drug Delivery: Design Strategies to Overcome Biological Barriers Effective drug delivery requires overcoming multiple biological barriers, including enzymatic degradation, immune clearance, and poor tissue penetration. This review systematically presents the design strategies for nanocarriers — including surface modification, stimuli-responsive release, and active targeting ligands — to enhance therapeutic index and specificity. We discuss recent advances in polymeric nanoparticles, liposomes, dendrimers, and exosome-based carriers, emphasizing their applications in cancer, infectious diseases, and neurological disorders Nanocarriers ; Drug delivery ; Drug ; Targeted drug delivery ; Nanotechnology ; Biochemical engineering ; Pharmacology ; Medicine ; Materials science ; Engineering Nanoparticle-Based Drug Delivery
Authors: Arman Suryani | Lutfi Chabib | Annisa Fitria | Siti Nurlina | Erza Ridha Kartika
Source: Journal of Applied Pharmaceutical Science (article, 2025-01-01)
Field: Materials Science — Biomaterials

Peppermint essential oil nanoliposomes: Innovative formulation for effective hair growth Peppermint essential oil is known to have properties that can stimulate hair growth by increasing blood circulation to the scalp and providing a soothing, cooling effect. However, the challenge is optimizing the delivery of these active ingredients to be more effective and safe. Therefore, the need to develop formulation modifications with the aim of drug delivery systems and nanoliposomes became the main objective of this study, which was to assess characterization, safety, and hair growth activity. Nanoliposomes were produced from a combination of Phospolipon® 80H and Phytosolve® lipoids using a thin-film hydration method. Ultrasonic dispersion and mini-extrusion methods were used to reduce the particle size. Nanoliposomes were evaluated descriptively and statistically for physical characteristics, irritation test, and hair growth effectiveness using Sprague Dawley male white rats as subjects. The nanoliposome particle size was 96.7 ± 1.9 nm, the polydispersity index (PdI) value was 0.4 ± 0.02 PdI, and the zeta potential value was −12.6 ± 0.5 mV with a round spherical shape without aggregation, milky yellow, thick with a distinctive peppermint aroma, and good homogeneity. The nanoliposome gel has met the accepted requirements through pH, viscosity, spreadability, adhesiveness, and microbial contamination limit tests. In the irritation test, all treatment groups showed no erythema and edema on the rat skin. Peppermint nanoliposome gel increased hair growth better than the other groups. Peppermint essential oil can be formulated into nanoliposome gel serum preparation and has good hair growth activity. Hair growth ; Materials science ; Medicine Silk-based biomaterials and applications ; Dyeing and Modifying Textile Fibers ; Skin Protection and Aging
Authors: Yogesh Chandra Nainwal
Source: Jabirian Journal of Biointerface Research in Pharmaceutics and Applied Chemistry (review, 2025-01-28)
Field: Materials Science — Materials Chemistry

NANOTECHNOLOGY IN AGRICULTURAL YIELD EXPANSION: A COMPEHENSIVE REVIEW This comprehensive review explores the burgeoning field of nanotechnology and its transformative impact on agricultural yield expansion. Nanotechnology offers unprecedented opportunities to address key challenges facing global agriculture, including soil degradation, resource inefficiency, pest and disease management, and climate change adaptation. By manipulating materials at the nanoscale, researchers have developed innovative solutions to enhance soil fertility, improve crop protection, optimize resource utilization, and promote sustainable farming practices. This paper examines recent advancements in nanofertilisers, nanopesticides, nanosensors, and precision agriculture technologies, providing insights into their mechanisms of action and potential benefits for crop productivity. Nanotechnology enables the development of nanorobots and nanoscale devices for automated farming operations and precision agriculture applications. Furthermore, environmental and safety considerations, as well as regulatory frameworks governing nanotechnology in agriculture, are discussed to ensure responsible and sustainable deployment of these technologies. Through case studies and practical examples, the review underscores the transformative potential of nanotechnology in revolutionizing agricultural practices and contributing to global food security. Finally, challenges, future perspectives, and recommendations for further research and implementation are outlined to guide the continued development and adoption of nanotechnology for agricultural yield expansion. Yield (engineering) ; Agriculture ; Nanotechnology ; Environmental science ; Materials science ; Biology ; Ecology ; Composite material Nanoparticles: synthesis and applications
Authors: Wenyan Ye | Xiaoya Zhao | Zhongyu Li | Xiaoyan Xu | Mouwei Liu | Liangliang Zhu
Source: Advanced Materials (article, 2025-10-15)
Field: Materials Science — Materials Chemistry

Water Treatment for Long‐Lived Room Temperature Phosphorescent Adhesives Polymer materials with long-lived room temperature phosphorescence (RTP) are promising because they are easy to process to fit broad luminescent events. However, these systems typically rely on polar groups to form hydrogen or ionic bonds to confine chromophores to produce long-lived RTP. Such interactions are susceptible to moisture, which greatly limits the stability of such materials and their luminescent signals. Here, long-lived RTP adhesives are developed by random copolymerization of a trace amount of chromophores into polyacrylic acid. For these polymers, a water-induced polymer reorganization can be observed at room temperature to form protective confined regions for chromophores, resulting in an afterglow lifetime up to 3 s, with a high moisture tolerance threshold. The strategy is applicable to diverse chromophores, resulting in RTP with a wide range of tunable emission colors. Meanwhile, these polymers are soluble in water and can be used as removable adhesives. The long-lived RTP can be employed to monitor sticking status non-destructively and precisely, which can inspire the development of high-performance RTP polymers for unprecedented practical applications. Phosphorescence ; Polymer ; Luminescence ; Polyacrylic acid ; Chromophore ; Afterglow ; Adhesive Luminescence and Fluorescent Materials ; Organic Light-Emitting Diodes Research ; Luminescence Properties of Advanced Materials
Authors: R. Thirumalaisamy | S. Nimithap | S. Harini | Rathika Rajiniganth | S. Haritha | Kalandar Ameer | P. Vadivel | T. Selvankumar
Source: International Journal of Advanced Science and Engineering (article, 2025-03-29)
Field: Materials Science — Materials Chemistry

Potential Application of Nanoemulsion in Agriculture: A Current Perspective The growing global population is driving the stipulation for food and agronomical resources.The application of traditional agrochemicals in the agriculture sector has wide-ranging consequences on both organisms and the environment.Prospects in formulating nanoemulsions used as nano delivery systems for agrochemicals in fields, crop protection, and farm animal management by improving animal and plant efficiency in agriculture.This review places emphasis on bio nanoemulsion formulation for different agricultural applications such as pesticides, fungicides, acaricides, insect and tick repellents, herbicides, and nematicides, which reduce toxicity and, in turn, improve environmental sustainability.Overall, nanoemulsion paves the way to more efficient, ecofriendly and reliable implementation in agronomics.The targeted active substance is advantageous using a method of nanoemulsion due to their unique size to surface area ratio.This allows better penetration through plant cuticles and insect agrochemicals.The controlled release mechanisms inherent in nanoemulsion systems can minimize the environmental impact of agrochemicals.By allowing for targeted application at lower dosages, nanoemulsions protect active ingredients from disintegration due to factors such as light and heat fluctuations.This stability ensures that the agrochemicals remain effective over longer periods, enhancing their usability in various agricultural settings. Perspective (graphical) ; Current (fluid) ; Agriculture ; Agricultural engineering ; Business ; Biochemical engineering ; Computer science ; Engineering ; Biology ; Artificial intelligence ; Electrical engineering ; Ecology Nanoparticles: synthesis and applications