jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Mainak Roy | Mujibullah Sheikh | Darshan R. Telange
Source: International Journal of Pharmaceutical Investigation (article, 2025-04-23)
Field: Materials Science — Biomaterials

Exploring Iron Oxide Nanoparticles Innovations and Applications in Cancer Therapy Iron Oxide Nanoparticles (IONPs) are exciting technology in cancer therapy that represents agents with a unique combination of super paramagnetism, biocompatibility and the capability for surface functionalization toward targeted applications. The following review describes the current innovations and various applications of IONPs against cancer, dealing with their roles in targeted drug delivery, hyperthermia and imaging. IONPs can be synthesized by various chemical and physical methods, for instance, co-precipitation or thermal decomposition. Characterization techniques for their structural and magnetic properties include transmission electron microscopy and vibrating sample magnetometry. IONPs allow for targeted drug delivery by the release of therapeutic agents at a specific location, reducing systemic toxicity. In magnetic hyperthermia applications, they exploit the ability to produce heat during the alternating magnetic field exposure and induce apoptosis in tumor cells. Moreover, IONPs serve as magnetic resonance contrast imaging agents, enhancing tumors' imaging. Even with the great promise of IONPs, concerns about toxicity and biocompatibility and scalable production methods have yet to be realized. Combination therapies interlacing IONPs with other therapeutic modalities, as well as further research into their elicited immunomodulatory effects, are some of the future perspectives that have been outlined. Taken together, advancements in IONP technology herald a new frontier in cancer therapy, offering innovative strategies to improve treatment efficacy and the lives of patients. Nanoparticle ; Nanotechnology ; Cancer therapy ; Materials science ; Cancer ; Iron oxide nanoparticles ; Computer science ; Medicine ; Internal medicine Nanoparticle-Based Drug Delivery
Authors: И. М. Давлетбаева | O. O. Sazonov
Source: Polymers (review, 2025-11-29)
Field: Materials Science — Polymers and Plastics

Macromolecular and Supramolecular Organization of Ionomers Ionomers are promising materials because ionic interactions and their reversible clustering provide sensitivity to stimuli and facilitate energy dissipation, polymer miscibility, and ion transport. The existence of a wide variety of interacting ionic groups and their associated macromolecular structures provides the basis for considering the supramolecular organization of ionic polymeric materials as a factor determining the emergence of specific properties. The main structural elements of ionomers are ionic clusters, and the properties of ionomers are determined by their sizes and size distribution. Ionomers are attractive for use in composites, actuators, coatings, dyed textiles, adhesives, shape-memory and self-healing materials, water purification membranes, and ion-exchange membranes for fuel cells and batteries. This paper presents a review of the macromolecular structure and supramolecular organization of ionomers and their properties, depending on the basis of their ionic functionalization. The ionic functions of ionomers are determined primarily by the type of ion (cations or anions) that serves as the basis for their functionalization. Ionomers containing both anionic and cationic pendant ions are considered, with attention given to the influence of the nature of the counterions used on the properties of ionomers. Ionic bonding ; Macromolecule ; Counterion ; Ionomer ; Supramolecular chemistry ; Cationic polymerization ; Polymer Polymer composites and self-healing ; Dielectric materials and actuators ; Ionic liquids properties and applications
Authors: Luoqi Wang | Hailong Xiong | Yuenan Zheng | Jiaqi Yang | Ye Wang | Zhen‐An Qiao
Source: Nano Research (article, 2025-06-04)
Field: Chemistry — Organic Chemistry

A polymer derived bubble templates strategy towards perovskite oxides with tunable pore structure and rich surface-active sites for boosting aerobic oxidation of benzyl alcohol Porous perovskite metal oxides (PPMOs) have emerged as promising candidates for efficient catalysts in fine chemical engineering due to their flexible crystal structures and tunable surface chemical properties. However, the conventional high temperature calcination process required for crystallization frequently leads to collapse of pore structure, limiting the practical application of PPOMs. Herein, we propose a facile and general polymer derived bubble templates strategy to synthesize a series of PPMOs including single-component PPMOs (<em>e.g.</em>, LaMnO<sub>3</sub>, LaFeO<sub>3</sub>, LaCoO<sub>3</sub>, PrMnO<sub>3</sub> and NdMnO<sub>3</sub>) and multiple-component PPMOs (<em>e.g.</em>, LaCo<em><sub>x</sub></em>Mn<em><sub>1-x</sub></em>O<sub>3</sub> (<em>x</em> = 0.1, 0.2, 0.3)) with tunable pore structure. The pore architectures (macropores, hierarchically meso/macropores, and mesopores), pore sizes, and specific surface areas (14 – 40 m<sup>2</sup> g<sup>-1</sup>) of the samples can be precisely tailored by adjusting the sizes of bubble templates. The hierarchically meso/macroporous LaMnO<sub>3</sub> features multiple structural advantages, including well-defined hierarchical porous architecture, high specific surface area and abundant oxygen vacancies, and exhibits a remarkable catalytic performance in oxidation of benzyl alcohol to benzaldehyde, with conversion and selectivity of 99% and 99%, respectively. This work not only provides a scalable and versatile pathway for fabricating advanced porous materials but also offers new perspectives for their application in diverse catalytic processes. Benzyl alcohol ; Template ; Materials science ; Boosting (machine learning) ; Perovskite (structure) ; Bubble ; Chemical engineering ; Porosity ; Polymer ; Alcohol ; Nanotechnology ; Catalysis ; Organic chemistry ; Chemistry ; Composite material ; Computer science Oxidative Organic Chemistry Reactions ; Catalytic Processes in Materials Science ; Catalysis and Oxidation Reactions
Authors: S. OTSUKA | B.J. Presley | Edison Zhu
Source: ChemRxiv (preprint, 2025-09-03)
Field: Materials Science — Materials Chemistry

Synergistic Catalytic Modulation of CO₂ Reactivity Toward C₈ Hydrocarbon Worldwide long-term consumption of petroleum has caused an increase in atmospheric carbon dioxide concentrations, leading to numerous ramifications: increased heat waves, ocean acidification, volatile weather conditions, etc. To combat this problem, modern researchers have looked into the conversion of atmospheric carbon dioxide into usable fuel, mitigating atmospheric carbon dioxide levels while simultaneously providing a solution to the declining availability of fossil fuels. The process of deriving usable fuel from carbon dioxide was dubbed hydrogenation of CO₂, involving a series of intricate steps, each necessitating a specific catalyst to drive the reaction towards the desired compound. To start, the reverse water-gas shift reaction is needed to convert carbon dioxide and hydrogen into carbon monoxide and water, more commonly known as syngas. Syngas is then fed into the Fischer-Tropsch Synthesis, the primary procedure in hydrogenation, which converts syngas into liquid hydrocarbons. However, such hydrocarbons are inherently smaller chains, as the amount of energy needed to convert syngas into hydrocarbons increases as the chain length increases, yielding only C₁-C₄ chains. To resolve this, a process known as oligomerization synthesizes identical smaller hydrocarbon chains into longer chains, in this case, octane. Yet even after such complex processes, the octane that is produced is not optimal for use. In actuality, the octane is in a linear form, which is inferior to its branched counterpart, yielding lower results and worse performance. Isomerization mitigates this process by restructuring the compound. Reactivity (psychology) ; Catalysis ; Hydrocarbon ; Modulation (music) ; Chemistry ; Organic chemistry ; Physics ; Medicine Catalytic Processes in Materials Science ; Catalysis and Oxidation Reactions ; Carbon dioxide utilization in catalysis
Authors: Haoyang Li | Qichen Lu | Fenghua Zhang | Qingda Liu | Jing Zhuang | Zhong Li | Xun Wang
Source: Nature Communications (article, 2025-07-01)
Field: Materials Science — Polymers and Plastics

Single-layer cluster ionic-chain networks with tetragonal pores Two-dimensional (2D) materials with intrinsic pores have attracted attention for catalytic and electronic applications. However, a significant gap exists between all-inorganic 2D networks with inorganic connectors and those with organic connectors due to the greater complexity of functionalizing inorganic molecules. Addressing this gap, we present a new class of 2D all-inorganic porous networks: single-layer cluster ionic-chain networks (CINs), constructed by using PW<sub>10</sub>M<sub>2</sub> (M = Mn, Co) polyoxometalate (POM) clusters as nodes and end-capping agents for ionic chains. The integration of POM clusters into these networks significantly alters the electronic and band structures. Notably, the Mn-based CIN exhibits extremely high catalytic activity, achieving a toluene oxidation conversion rate of over 1.45 mmol g<sup>-1</sup> h<sup>-1</sup>. Calculations suggest that POM clusters act as an 'electron buffer', stabilizing electron density at Mn sites and lowering the activation energy for toluene oxidation. This development showcases POM clusters as 'superatom' capping agents, establishing a pathway for all-inorganic 2D networks that could advance new catalytic materials with unique electronic properties. Tetragonal crystal system ; Cluster (spacecraft) ; Ionic bonding ; Chain (unit) ; Layer (electronics) ; Materials science ; Computer science ; Chemical engineering ; Chemistry ; Nanotechnology ; Crystallography ; Ion ; Physics ; Crystal structure ; Computer network Conducting polymers and applications ; Covalent Organic Framework Applications ; Mesoporous Materials and Catalysis
Authors: Neha R. Thakare | Achyut Konwar | Pronami Gogoi | Pankaj Bharali | Rajiv Goswami | Swapnali Hazarika
Source: Journal of Applied Polymer Science (article, 2025-06-09)
Field: Materials Science — Biomaterials

<scp>MOF</scp> Functionalized Polycaprolactone—Polyvinyl Alcohol Bilayer Electrospun Scaffold for Biomedical Application ABSTRACT This study focuses on the metal–organic framework (MOF) functionalization of a porous polycaprolactone (PCL) fibrous network and its influence on cell attachment and proliferation. The network was fabricated via electrospinning, then modified through dip‐coating with polyvinyl alcohol (PVA), followed by coating with a MOF (MOF UiO‐66‐NH 2 ) and Cephalexin (CEX). The BET analysis confirms the microporous structure of the functionalized scaffold. The PVA‐coated scaffold showed a lower contact angle, which was further increased following MOF coating. The MOF‐coated composite showed a minor decrease in tensile strength after water treatment (~18%) compared to the PVA coating (~25%), demonstrating the water stability of the scaffold. Antibacterial studies showed the effectiveness of MOF, which was further enhanced by the encapsulation of CEX ~62%. The dual‐functionalized scaffold effectively targets S. aureus and E. coli bacteria. Multiple antibacterial mechanisms were observed against E. coli , showing the scaffold's effectiveness against antibiotic‐resistant bacteria. SEM analysis revealed a significant increase in L929 cell growth on the scaffold within 24 h, indicating no cytotoxic effects. The rounded‐to‐spindle‐shaped cells on the functionalized bi‐layer scaffolds indicate the strong potential for faster wound healing compared to the PCL scaffold. The microporous structure with a large surface area can also enhance cell proliferation. Polyvinyl alcohol ; Polycaprolactone ; Bilayer ; Materials science ; Electrospinning ; Scaffold ; Chemical engineering ; Polymer chemistry ; Polymer science ; Composite material ; Polymer ; Membrane ; Chemistry ; Biomedical engineering Electrospun Nanofibers in Biomedical Applications ; Metal-Organic Frameworks: Synthesis and Applications ; Graphene and Nanomaterials Applications
Authors: Nanna L. Baun | Sabina Svava Mortensen | Heloisa N. Bordallo | Kirsten M. Ø. Jensen | Adam F. Sapnik
Source: Nature Communications (preprint, 2025-02-27)
Field: Materials Science — Materials Chemistry

Direct Synthesis of Amorphous Metal–Organic Frameworks from Nanoclusters The direct synthesis of amorphous metal-organic frameworks (aMOFs) is an appealing yet often avoided approach due to the perceived unpredictability of amorphous network formation. Here, we develop a strategy for aMOF synthesis using pre-formed nanoclusters and rigid organic linkers, providing enhanced control over disorder and defect chemistry while bypassing the traditional crystallise-amorphise approach. By systematically comparing this approach to other direct synthesis routes and using X-ray pair distribution function, thermogravimetric, and statistical analyses, we establish key design principles governing aMOF formation. We demonstrate that kinetic control-fast reactions under basic conditions at room temperature-suppresses crystallisation and drives amorphous network formation. The nanocluster approach consistently yields highly disordered frameworks with the shortest coherence lengths among direct synthesis methods. Additionally, we show that tuning metal composition through doping with kinetically inert cations restricts coordination reversibility, significantly increasing defect density and structural disorder. Structural analysis reveals that while aMOFs share motifs with crystalline polymorphs, they cannot be directly mapped onto known structures, highlighting the importance of more nuanced characterisation approaches. By developing a systematic approach to aMOF design, this work provides a foundation for tailoring structural disorder, expanding their potential for catalysis, adsorption, and transport applications. Nanoclusters ; Metal-organic framework ; Amorphous solid ; Materials science ; Nanotechnology ; Chemical engineering ; Chemistry ; Organic chemistry ; Adsorption ; Engineering Nanocluster Synthesis and Applications ; Metal-Organic Frameworks: Synthesis and Applications ; Nanomaterials for catalytic reactions
Authors: Pengfei Ruan | Haonan Xiang | Wenbin Yi | Jieping Wang
Source: Nature Communications (article, 2025-07-01)
Field: Chemistry — Organic Chemistry

N-alkylated polydithiocarbamates derived from thiocarbonyl fluoride as macro-photoiniferters for living 3D printing Polydithiocarbamates represent a unique class of sulfur-containing polymers possessing advanced functionalities. However, their structural and functional exploration has been limited by significant synthetic challenges. Existing methods primarily yield polydithiocarbamates incorporating secondary amides within the polymer backbone. Herein, we report a versatile synthetic strategy enabling access to previously inaccessible N-alkylated polydithiocarbamates. Utilizing secondary diamines, dithiols, and thiocarbonyl fluoride, we efficiently synthesize these polymers with diverse structures. Notably, these materials function as superior macro-photoiniferters for fully open-to-air 3D printing, exhibiting enhanced resolution and outperforming small-molecule analogues. Critically, the dormant dithiocarbamate functionalities within the 3D-printed structures can be reactivated for iterative modifications, demonstrating the potential for living 3D printing. More interestingly, the unique capability of the macro-photoiniferter (P1) to eliminate stair-stepping layer patterns without requiring printer modifications or additional pre- or post-processing steps represents a simple yet powerful approach that could substantially enhance the flexibility and output quality of DLP 3D printing. We demonstrate that thiocarbonyl fluoride is a key reagent for the controlled synthesis of sulfur-containing polymers. We anticipate that our polydithiocarbamate-based macro-photoiniferters will drive advancements in diverse fields, including biomedicine, energy, and materials science. Macro ; Fluoride ; Alkylation ; Chemistry ; Computer science ; Biochemistry ; Programming language ; Inorganic chemistry Photopolymerization techniques and applications ; Photochromic and Fluorescence Chemistry ; Advanced Polymer Synthesis and Characterization
Authors: Lin Liu | Qi Zhang | Xue Leng | Rui Song | Zheng‐Bo Han
Source: Polymers (article, 2025-06-06)
Field: Materials Science — Materials Chemistry

Architecting Porosity Through Monomer Engineering: Hypercrosslinked Polymers for Highly Selective CO2 Capture from CH4 or N2 Natural gas purification and the mitigation of carbon dioxide (CO<sub>2</sub>) emissions from flue gases are critical steps in alleviating the greenhouse effect and significantly mitigate multiple environmental challenges associated with global warming. Hypercrosslinked polymers (HCPs) have become a hot topic as prospective adsorbents for gas purification and separation, owing to their low cost and scalability. Hence, TPB-Ben, TPB-Nap, and TPB-Ant were synthesized through a solvent knitting strategy, with the modification in the size of the monomers serving as a distinctive feature. This alteration aimed to explore the impact of phenyl ring quantity on the polymers' gas adsorption and separation efficiency. All HCPs showed outstanding selective separation capability of CO<sub>2</sub> from CO<sub>2</sub>/CH<sub>4</sub> and CO<sub>2</sub>/N<sub>2</sub> mixtures, such as TPB-Ben-3-2 (CO<sub>2</sub>/CH<sub>4</sub>: 10.77; CO<sub>2</sub>/N<sub>2</sub>: 59.72), TPB-Nap-3-2 (CO<sub>2</sub>/CH<sub>4</sub>: 9.12; CO<sub>2</sub>/N<sub>2</sub>: 61.31), and TPB-Ant-3-2 (CO<sub>2</sub>/CH<sub>4</sub>: 10.00; CO<sub>2</sub>/N<sub>2</sub>: 62.89), which could be potential candidate adsorbents for natural gas purification and CO<sub>2</sub> capture. Considering the mild reaction conditions, low cost, efficient gas adsorption, and the potential for scalable production, these polymers are considered ideal selective solid adsorbents for capturing CO<sub>2</sub>. This further highlights the significance of the solvent knitting strategy. Adsorption ; Flue gas ; Polymer ; Chemical engineering ; Materials science ; Solvent ; Greenhouse gas ; Carbon dioxide ; Monomer ; Gas separation ; Natural gas ; Environmental science ; Process engineering ; Organic chemistry ; Chemistry ; Composite material ; Engineering Covalent Organic Framework Applications ; Carbon Dioxide Capture Technologies ; Metal-Organic Frameworks: Synthesis and Applications
Authors: Shiva Kargar | Dawood Elhamifar
Source: Nanoscale Advances (article, 2025-01-01)
Field: Chemistry — Organic Chemistry

Palladium-containing magnetic UiO-66–NH <sub>2</sub> as a highly powerful and recoverable nanocatalyst for the reduction of nitrobenzenes Magnetically recoverable porous materials with tunable surface chemistry are of growing interest for heterogeneous catalysis due to their ease of separation, structural versatility, and high surface accessibility. However, integrating multiple functional components into a single stable and reusable catalytic platform remains a significant challenge. In this study, the design and synthesis of a hierarchical nanocomposite, Fe<sub>3</sub>O<sub>4</sub>@MCM-41@UiO-66/SB-Pd, through a stepwise functionalization approach are reported. The strategy integrates a magnetic Fe<sub>3</sub>O<sub>4</sub> core, mesoporous silica, a microporous UiO-66-NH<sub>2</sub> framework, and a Schiff base-coordinated Pd complex to yield a structurally ordered and catalytically active nanocomposite. The resulting nanomaterial exhibited a high surface area (249.1 m<sup>2</sup> g<sup>-1</sup>), hierarchical porosity, thermal stability, and superparamagnetic behavior. Comprehensive characterization confirmed the successful incorporation of all functional groups while maintaining crystallinity. The Fe<sub>3</sub>O<sub>4</sub>@MCM-41@UiO-66/SB-Pd nanocomposite demonstrated high catalytic efficiency for the reduction of nitroarenes under mild conditions, along with excellent reusability. These results highlight a promising approach for designing hybrid catalytic materials with hierarchical porosity, enhanced stability, and practical recyclability for environmentally relevant transformations. Microporous material ; Catalysis ; Nanomaterials ; Mesoporous material ; Superparamagnetism ; Nitrobenzene ; Yield (engineering) ; Heterogeneous catalysis ; Surface modification Nanomaterials for catalytic reactions ; Catalytic Processes in Materials Science ; Ammonia Synthesis and Nitrogen Reduction
Authors: Dimitra Toumpa | Athina Angelopoulou | Konstantinos Avgoustakis | George Pasparakis
Source: Journal of Materials Chemistry B (article, 2025-01-01)
Field: Materials Science — Biomaterials

Ultrasonic activation of polymer–drug conjugates for targeted and combinational pancreatic cancer therapy In this work, we present a series of polymer-drug conjugates (PDCs) incorporating gemcitabine (GEM) and camptothecin (CPT), linked to polymethacrylate backbones <i>via</i> ester and disulfide linkers. Using monomeric prodrug precursors, we employed reversible addition-fragmentation chain transfer (RAFT) polymerization to synthesize colloidally stable PDCs. Upon ultrasound irradiation, these PDCs exhibited accelerated drug release, which was further enhanced by the presence of a sonosensitizer due to reactive oxygen species (ROS) generation. Systematic <i>in vitro</i> testing across different treatment modalities revealed formulations capable of outperforming the IC<sub>50</sub> values of the parent drugs by up to five orders of magnitude. Our findings highlight how the interplay between the PDC structure (<i>e.g.</i>, drug combinations and linkers) and ultrasound-triggered activation in the presence of a sonosensitizer significantly enhances the therapeutic potency of these nanomedicines. Conjugate ; Drug ; Pancreatic cancer ; Materials science ; Polymer ; Ultrasonic sensor ; Cancer therapy ; Cancer ; Nanotechnology ; Cancer research ; Medicine ; Pharmacology ; Internal medicine ; Composite material ; Radiology Nanoparticle-Based Drug Delivery ; 3D Printing in Biomedical Research