jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: M. Dolores Tenorio | Alejandro Salinas | Callum McGregor | Katalin Kovács | Milko A. Jorquera | Mara Cea
Source: New Biotechnology (article, 2025-12-19)
Field: Materials Science — Biomaterials

Production of poly(3-hydroxybutyrate-co-3-hydroxypropionate) with regulated monomeric ratios from crude glycerol by recombinant Cupriavidus necator H16 Poly(3-hydroxybutyrate-co-3-hydroxypropionate), also known as P(3HB-co-3HP), is a microbially produced biopolymer proposed as a sustainable alternative to petroleum-based plastics. However, most biosynthetic pathways for its production rely on costly precursor or cofactor supplementation, limiting their industrial applicability. In this study, Cupriavidus necator H16 was engineered to produce P(3HB-co-3HP) directly from central metabolism by introducing a heterologous β-alanine pathway for 3HP biosynthesis. Two strategies were employed to modulate copolymer composition: (i) a constitutive pathway modulated by nitrogen availability, and (ii) an arabinose-inducible system regulating the synthesis of the pathway intermediate β-alanine. Both approaches enabled the production of copolymers with adjustable 3HP content without the need for external precursors or cofactors. The N-based strategy achieved a maximum 3HP content of 66.5 mol% with a PHA titer of 1.1 g/L, while the inducible system allowed finer monomer control and reached up to 51.7 mol% 3HP with a PHA titer of 2.5 g/L. Additionally, copolymer production was demonstrated using crude glycerol as the sole carbon source, where the 3HP incorporation was tunable from 6.9 to 37.7 mol%, depending on the arabinose concentration, and the PHA titer ranged from 1.6 to 2.0 g/L. This study highlights the potential of the β-alanine pathway for sustainable 3HP-containing copolymers biosynthesis and demonstrates the feasibility of using crude glycerol, to support cost-effective bioplastic production. Cupriavidus necator ; Polyhydroxyalkanoates ; Biopolymer ; Monomer ; Glycerol ; Heterologous ; Copolymer ; Biosynthesis ; Bioplastic biodegradable polymer synthesis and properties ; Microbial Metabolic Engineering and Bioproduction ; Catalysis for Biomass Conversion
Authors: Mukesh Kumar | Subham Manda | Km. Bhumika | Shadab Ali | Iram Jahan | Suraj Mandal
Source: International Journal of Health Sciences and Engineering (article, 2025-02-17)
Field: Materials Science — Biomaterials

Targeted Drug Delivery Systems in Oncology: A Review of Recent Patents and future directions Cancer remains a global health challenge, necessitating innovative treatment strategies to improve outcomes while minimizing side effects. Targeted Drug Delivery Systems (TDDS) have revolutionized oncology by addressing limitations of traditional chemotherapy, such as systemic toxicity, lack of specificity, and drug resistance. Utilizing nanotechnology, biomarker-based targeting, and immunotherapy, TDDS enables precise drug delivery to tumors, enhancing efficacy while protecting healthy tissues. Nanotechnology has facilitated the development of liposomes, dendrimers, micelles, and solid lipid nanoparticles, leveraging the Enhanced Permeability and Retention (EPR) effect for tumor accumulation. Examples like Doxil, a PEGylated liposomal doxorubicin, have improved ovarian cancer treatment by reducing cardiotoxicity. Biomarker-based approaches, such as antibody-drug conjugates (ADCs), further enhance specificity. Trastuzumab emtansine (Kadcyla), targeting HER2-positive breast cancer, has demonstrated improved survival rates. TDDS also integrates with immunotherapy to boost immune checkpoint inhibitors, enhance antigen delivery, and optimize cytokine therapy. Lipid nanoparticles and dendrimers are being engineered to improve immune responses while minimizing adverse effects. However, challenges such as tumor heterogeneity, drug resistance, high production costs, and regulatory barriers limit widespread adoption. Ongoing research focuses on overcoming these barriers through personalized medicine, AI-driven designs, and sustainable platforms. TDDS represents a paradigm shift in oncology, combining precision and safety to improve patient outcomes. By integrating emerging technologies and addressing current limitations, TDDS holds the potential to transform cancer treatment, offering hope for better survival and quality of life. Drug delivery ; Targeted drug delivery ; Drug ; Immunotherapy ; Adverse effect ; Cancer immunotherapy ; Cancer ; Targeted therapy ; Cancer therapy Nanoparticle-Based Drug Delivery ; Cancer Research and Treatment ; Nanoplatforms for cancer theranostics
Authors: A. Vidal-Crespo | A.F. Manchón-Gordón | José María Martín‐Olalla | Francisco Javier Romero | J.J. Ipus | M. C. Gallardo | J.S. Blázquez | C.F. Conde
Source: ArXiv.org (preprint, 2025-02-03)
Field: Materials Science — Materials Chemistry

Phase dependence of the Thermal Memory Effect in Polycrystalline Ribbon and Bulk Ni55Fe19Ga26 Heusler Alloys The thermal memory effect, TME, has been studied in Ni55Fe19Ga26 shape memory alloys, fabricated as ribbons via melt-spinning and as pellets via arc-melting, to evaluate its dependence on the martensitic structure and the macrostructure of the samples. When the reverse martensitic transformation is interrupted, a kinetic delay in the subsequent complete transformation is only evident in the ribbon samples, where the 14M modulated structure is the dominant phase. In contrast, degradation of the modulated structure or the presence of the gamma-phase significantly reduces the observed TME. In such cases, the magnitude of the TME approaches the detection limits of commercial calorimeters, and only high-resolution calorimeter at very low heating rate (40 mK h-1) can show the effect. Following the kinetic arrest and subsequent cooling, the reverse martensitic transformation was completed at several heating rates to confirm the athermal nature of the phenomenon. Materials science ; Ribbon ; Crystallite ; Condensed matter physics ; Thermal ; Engineering physics ; Metallurgy ; Composite material ; Thermodynamics ; Physics Shape Memory Alloy Transformations
Authors: Xiaoqian He | Kejie Guan | Fuqin Sun | Xiaoshuang Gou | Lin Liu | Yingyi Wang | Weifan Zhou | Yang Xia | Cheng Zhang | Hao Dai | Zhanxia Zhao | Xiaowei Wang | Ting Zhang
Source: Microsystems & Nanoengineering (article, 2025-09-29)
Field: Materials Science — Materials Chemistry

Polarity control of 2D semiconductor for reconfigurable electronics The controllable modulation of carrier polarity in semiconductors is essential for enabling dynamic configurations in reconfigurable devices. Ambipolar two-dimensional (2D) semiconductors, characterized by their atomic-scale thickness and excellent gate modulation efficiency, have emerged as highly promising channel materials for such devices. However, existing methods for polarity control encounter challenges in achieving reversible modulation during device operation. Here, we report a novel strategy for reversibly modulating the polarity of ambipolar 2D semiconductors through gate-controlled charge trapping. We demonstrate a double-gate TaO<sub>x</sub>/WSe<sub>2</sub>/h-BN field-effect transistor, which can reversibly switch between n-type and p-type transport characteristics via electric-field-driven bipolar charge trapping at the TaO<sub>x</sub>/WSe<sub>2</sub> interface. With this method, an electrically configurable complementary inverter is created with a single WSe<sub>2</sub> flake, exhibiting a power consumption of just 0.7 nW. Additionally, a programmable p-n/n-p diode is realized with a > 100,000-fold change in the rectification ratio. These results demonstrate the great potential of gate-controlled bipolar charge trapping for advancing reconfigurable electronics. Ambipolar diffusion ; Polarity (international relations) ; Modulation (music) ; Rectification ; Diode ; Semiconductor ; Power consumption ; Logic gate ; Semiconductor device 2D Materials and Applications ; Advanced Memory and Neural Computing ; Ferroelectric and Negative Capacitance Devices
Authors: Mohammad Ghorbanzadeh Nazarlu | Seyedeh Masoumeh Hafezi | Payam Ghorbannezhad | Majid Azizi
Source: Research Square (preprint, 2025-11-18)
Field: Materials Science — Polymers and Plastics

Life Cycle Assessment of MDF Production: Implementing Biobased Production Strategies Life-cycle assessment ; Production (economics) ; Environmental impact assessment ; Raw material ; Resource (disambiguation) ; Human life ; Resource depletion ; Human health ; Ecotoxicity Natural Fiber Reinforced Composites ; Fiber-reinforced polymer composites ; Advanced Cellulose Research Studies
Authors: Paweł Mateusz Nowak | Dariusz Maciej Pisklak | Łukasz Szeleszczuk
Source: Sustainable Chemistry and Pharmacy (article, 2025-09-23)
Field: Chemistry — Organic Chemistry

Green chemistry meets theoretical chemistry – comparison of 24 quantum chemical methods for calculating NMR shielding constants using the RGB model The idea of green chemistry has already found many recipients, but not yet among computational chemists. Although theoretical methods indeed do not use chemical reagents and do not produce laboratory waste, due to the complexity of calculations they often require a lot of energy and can generate a significant carbon footprint. In our opinion, the basic question is not “Should we take into account the carbon footprint of computational methods in their assessment?”, but “How to do it properly?” In this work, we have attempted to address this issue by using an RGB model, a well-known tool used for assessing analytical chemistry methods, that has been adapted to the specifics of computational chemistry (RGB_in-silico). The model uses three primary parameters: the calculation error (red), the carbon footprint resulting from the energy consumption of the computer (green), and the computation time (blue). In phase I, acceptability thresholds are adopted. Methods that are unacceptable in at least one aspect are rejected. In phase II methods are comprehensively compared in terms of “whiteness”. The model was validated on 24 quantum chemical methods for calculating NMR shielding constants, differing in functionals and basis sets. The obtained results indicate a huge discrepancy between the methods, and therefore, the need to use a dedicated tool for selecting the optimal one in a rational way. The large values of the carbon footprint clearly indicate that some computational methods cannot be considered as “green in nature”. The RGB_in-silico model seems to be a simple and useful metric. • Green chemistry applies both to laboratory and computational methods. • Computer calculations generate a varied carbon footprint which needs to be analyzed. • Most accurate methods can be time-inefficient and energy-intensive. • The use of a dedicated metric is recommended. • The RGB_in-silico model allows one to compare theoretical chemistry methods. Quantum chemistry ; Carbon footprint ; Chemical shift ; Basis (linear algebra) ; Computation ; Quantum chemical ; Simple (philosophy) ; Green chemistry ; Carbon fibers Free Radicals and Antioxidants ; Various Chemistry Research Topics ; Thermal and Kinetic Analysis
Authors: José Manuel Lorenzo | Leticia Pereira Correa | Paulo Cezar Bastianello Campagnol
Source: Food Science and Processing (article, 2025-12-09)
Field: Materials Science — Biomaterials

Psyllium (Plantago ovata) in Meat Product Reformulation: Technological, Nutritional, and Functional Perspectives This review summarizes current knowledge on the technological, nutritional, and functional applications of psyllium (Plantago ovata) in meat products. It discusses the structural and compositional characteristics of psyllium that underlie its hydrocolloid behavior, including water-binding, emulsifying, and gelling capacities, and examines its impact on emulsion stability, texture, oxidative stability, and sensory quality across different meat matrices. The review also explores psyllium’s nutritional contributions as a source of soluble dietary fiber and its potential to reduce fat, sodium, and phosphate content. Recent advances in its molecular interactions with myofibrillar proteins and biopolymers, and its use in emerging processing technologies, are critically evaluated. Research gaps and future perspectives are highlighted, emphasizing the need for mechanistic understanding, process optimization, and validation of bioactive effects in psyllium-enriched meats. Overall, this review positions psyllium as a multifunctional ingredient for developing healthier, cleaner-label, and more sustainable meat products. Psyllium ; Ingredient ; Dietary fiber ; Product (mathematics) ; Health benefits ; Meat packing industry ; Quality (philosophy) Nanocomposite Films for Food Packaging ; Food composition and properties ; Proteins in Food Systems
Authors: Steve Cripps
Source: Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences (review, 2025-05-22)
Field: Chemistry — Organic Chemistry

Microwave power sources for industrial, scientific and medical applications The industrial, scientific and medical (ISM) sector has been a growth area in recent years for applications of microwave engineering. These applications include various forms of heating and more controversial uses that exploit so-called 'non-thermal' effects of microwave exposure on biological and chemical samples. Given the non-thermal nature of these effects, the microwave power source may be adequate in pulsed, rather than continuous form. This paper will not attempt to address the questions surrounding the provenance of such effects but will discuss the challenges presented to the microwave circuit designer in delivering substantial amounts of microwave power, both continuous and pulsed, to targets that vary in size and microwave impedance properties. ISM applications may represent a large new market for radio frequency power amplifier (RFPA) products that may utilize alternative technologies and design approaches over those that have evolved for the conventional microwave applications such as telecommunications and radar.This article is part of the discussion meeting issue 'Microwave science in sustainability'. Microwave ; Exploit ; Radar ; Amplifier ; Power (physics) ; Electrical engineering ; Computer science ; Telecommunications ; Electronic engineering ; Engineering physics ; Engineering ; CMOS ; Physics Microwave-Assisted Synthesis and Applications ; Microwave and Dielectric Measurement Techniques ; Radio Frequency Integrated Circuit Design
Authors: Michael O. Glocker | Cornelia Koy | Timo Zimmer | Kwabena F.M. Opuni | Armin Geyer
Source: Research Square (preprint, 2025-07-24)
Field: Chemistry — Spectroscopy

Mass Spectrometric ITEM-FIVE Analysis Reveals Increasing Trimer Stability of T4 Fibritin Foldon Variants Upon Introduction of N-terminal Amino Acid Residues with Artificial Space-Demanding Side-chains Trimer ; Terminal (telecommunication) ; Space (punctuation) ; Amino acid residue ; Stability (learning theory) ; Side chain ; Amino terminal ; Amino acid ; Chemistry ; Stereochemistry ; Peptide sequence ; Computer science ; Biochemistry ; Organic chemistry ; Machine learning ; Polymer Advanced Proteomics Techniques and Applications ; Mass Spectrometry Techniques and Applications ; Protein Structure and Dynamics
Authors: AEM (Azerbaijan Science Center)
Source:  (article, 2025-02-13)
Field: Chemistry — Physical and Theoretical Chemistry

SCIENTIFIC RESEARCHES XXIII INTERNATIONAL SCIENTIFIC CONFERENCE 1. Interactive Platforms and Software: a) PhET Interactive Simulations is an online interactive platform developed by the university.This platform provides users with a visual representation of biological processes and concepts, allowing them to gain hands-on experience in lessons through experiments and simulations.PhET offers interactive simulations on a variety of topics, such as cell biology, genetics, and ecology.These simulations provide learners with a deeper understanding and help make lessons more engaging and interactive.b) Virtual Microscope -is a program that allows students to study biological samples observed with a microscope.This program allows students to examine different biological cell types, tissue structures, and microorganisms through a microscope.Virtual microscopes help make the teaching process more effective and comprehensive, without the need for extensive equipment and time in laboratories.In addition, with this technology, students can compare different samples and learn at different magnification levels.c) Labster -Labster is a platform that provides virtual laboratory experiments in various fields of biological sciences.Students can conduct virtual experiments in fields such as bioinformatics, molecular biology, ecology, genetic engineering on this platform.Labster offers 3D visualization, interactive simulations, and hands-on experience opportunities to make scientific concepts easier to understand.Students can combine both theoretical and practical knowledge with this tool.2. Computer science ; Engineering ethics ; Political science ; Engineering History and advancements in chemistry ; Ukraine: War, Education, Health ; International Science and Diplomacy
Authors: Rismen Sinambela
Source: Science Get Journal. (article, 2025-10-25)
Field: Chemistry — Analytical Chemistry

Mass Spectrometry-Based Purity Assessment of Hydrogen from Different Production Pathways: Compliance Evaluation with ISO 14687:2019 Standards The global transition toward low-carbon energy has positioned hydrogen (H₂) as a key renewable fuel, particularly for applications in fuel cells that require ultra-high purity. Ensuring hydrogen quality is essential to prevent catalyst poisoning and system degradation, as defined in ISO 14687:2019 standards. This study presents a simulation-based analysis of hydrogen purity using a Gas Chromatography–Mass Spectrometry (GC–MS) modeling approach to evaluate three production pathways: green hydrogen (from electrolysis), grey hydrogen (from steam methane reforming), and a fuel cell–grade feedstock.The simulation predicts impurity profiles such as O₂, N₂, CO, CO₂, CH₄, sulfur compounds, and water vapor, comparing each with ISO threshold limits. Results indicate that green hydrogen generally complies with ISO standards, while grey hydrogen exceeds CO₂ and sulfur limits. The fuel cell–grade sample shows near-complete conformity due to simulated purification processes such as pressure swing adsorption.These findings highlight that analytical modeling can effectively predict hydrogen quality and compliance potential across different production routes. The study emphasizes that advancing hydrogen technology requires not only cleaner production methods but also reliable analytical simulations to support quality assurance and sustainability in future hydrogen economies. Hydrogen ; Hydrogen production ; Steam reforming ; Hydrogen fuel ; Hydrogen economy ; Renewable energy ; Hydrogen fuel enhancement ; Hydrogen purifier Analytical chemistry methods development
Authors: Z. Viskadourakis | M. Orfanou | Anna Theodosi | Odysseas Tsilipakos | E. Koudoumas | G. Kenanakis
Source: Discover Sensors (article, 2025-12-31)
Field: Materials Science — Electronic, Optical and Magnetic Materials

3D-printed split ring resonators as potential microwave strain sensors In the current study, mm-scale, split ring resonator meta-atoms are tested as potential strain sensors. In particular highly flexible, stand-alone split ring resonators were developed employing the so-called stereolithography technique, and subsequently coated with conductive silver paste, to achieve high electrical conductivity. All of them, exhibit sizable resonance features in the frequency regime 3–8 GHz, depending on their dimensionality. In order to study their electromagnetic response upon strain deformations, meta-atoms were attached on highly flexible stripes, made of acrylic joint sealant. In all cases, a clear shift of the linear electromagnetic response was recorded, upon strain induced (up to 40%), enabling their sensing capability. Such experimental results were further confirmed by corresponding theoretical simulations. The performance of such strain sensors was evaluated through strain sensitivity and strain gauge factor, reaching up to 6.1 MHz/%, and 0.144 respectively. On the other hand, the electromagnetic performance of the SRRs, in the presence of strain, was verified through the quality factor, laying in the range 40–50, while the measurement error was found to be 2.3–14%, depending on the sample. Moreover, all resonators exhibited high durability in fatigue experiments, as well as they did not show any hysteretic behavior, upon a full stress-destress cycle. Thus, 3D—printed split ring resonator metasurfaces emerge as potential candidates for strain sensing applications. Resonator ; Split-ring resonator ; Strain (injury) ; Strain gauge ; Microwave ; Resonance (particle physics) ; Electrical conductor ; Stereolithography Metamaterials and Metasurfaces Applications ; Electromagnetic wave absorption materials ; Microwave and Dielectric Measurement Techniques
Authors: Tra Huynh | Nguyen Ngoc Tri Huynh | Huy Tran | Long Bach Tran | Linh Hai Nguyen
Source: Journal of Applied Biology & Biotechnology (article, 2025-01-01)
Field: Materials Science — Biomaterials

Isolation and selection of bacterial strains capable of degrading starch and accumulating polyphosphate from vermicelli production wastewater Currently, the issue of water pollution has become alarming worldwide, as numerous food production factories overlook wastewater treatment before discharging into the environment. Therefore, the isolation and selection of potential bacterial strains from wastewater are problems that need attention. The present study has isolated 32 bacterial strains from the wastewater source of the vermicelli production process in Can Tho City, Vietnam. The isolated bacterial strains exhibited various characteristics such as yellow, creamy white, or opaque white colors; convex or raised elevations; and entire or lobate margins, with bacterial colony sizes ranging from 0.5 to 3.5 mm. By performing the agar well diffusion method, the study selected three bacterial strains, P2, P12, and Y9, which demonstrated the ability to degrade starch. In particular, the Y9 strain exhibited the highest reducing sugar content (1.70–4.64 mg/mL) between the 2nd and 8th days of observation. Additionally, the Y11 strain demonstrated the ability to accumulate polyphosphate granules within cells, with the highest content reaching 1.79 mg/L P2O5. Results from the 16S rRNA gene sequencing method combined with several biochemical tests showed that Y9 and Y11 strains corresponded to Chryseobacterium daecheongense and Bacillus velezensis, respectively, with a similarity of 100%. Starch ; Bacteria ; Isolation (microbiology) ; Wastewater ; Strain (injury) ; Agar ; Polyphosphate ; 16S ribosomal RNA ; Agar plate biodegradable polymer synthesis and properties ; Phosphorus and nutrient management
Authors: Mo Li | Xueguo Chen | Xinxin Xia | Ting Zhang | Wenji Zhang | Qingxin Xu | Xin Zhao
Source: Frontiers in Nutrition (article, 2025-11-24)
Field: Chemistry — Spectroscopy

A ratiometric fluorescent sensor for Al3+ and Cu2+ detection in food samples The fluorescent sensor features simple synthesis, rapid detection, and high sensitivity, making it well-suited for the rapid detection of Al<sup>3+</sup> and Cu<sup>2+</sup> in foods such as fried dough twists and shellfish. Fluorescence ; Food products ; Food processing ; Detection limit ; Simple (philosophy) Molecular Sensors and Ion Detection ; Carbon and Quantum Dots Applications ; Trace Elements in Health