jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Parya Shirmohammadi | Nafiseh Soltanizadeh | Milad Fathi | Alireza Allafchian
Source: npj Science of Food (article, 2026-01-09)
Field: Materials Science — Biomaterials

Nozzle-less electrospun eugenol-loaded gelatin nanofibers: effect on fish preservation and quality enhancement This study evaluates the feasibility of producing nozzle-less eugenol-infused gelatin nanofibers as active coatings to improve fish quality and shelf life during cold storage. Nanofibers were fabricated using nozzle-less electrospinning with gelatin concentrations of 10-20% and gelatin:eugenol ratios of 100:0 to 50:50. The optimal formulation-20% gelatin with a 50:50 ratio-achieved >99.98% encapsulation efficiency and the smallest average fiber diameter (91.11 ± 18.53 nm). FTIR confirmed strong hydrogen bonding between gelatin and eugenol, while TGA indicated improved thermal stability. Higher eugenol loading enhanced antioxidant activity, limiting lipid oxidation to <0.15 mg MDA/kg compared with >1 mg MDA/kg in controls after 3 days. Microbial counts in coated fish at day 7 (2.80 log CFU/g) remained lower than uncoated samples at day 3 (3.88 log CFU/g). The coating also preserved texture and color throughout storage. Overall, these findings highlight the potential of bioactive nanofiber coatings for food preservation and waste reduction. Gelatin ; Nanofiber ; Electrospinning ; Coating ; Shelf life ; Lipid oxidation ; Food preservation ; Fourier transform infrared spectroscopy Electrospun Nanofibers in Biomedical Applications ; Nanocomposite Films for Food Packaging ; Meat and Animal Product Quality
Authors: Sheemaiah Kylle L. Hasim | Mary Chris M. Castillo | Riza Jane T. Andig | Julio Raymundo M. Pasagui | Judie L. Velasco
Source: International journal of research and scientific innovation (article, 2026-01-01)
Field: Chemistry — Organic Chemistry

Pharmacological Evaluation of Imperata Cylindrica Crude Extract as Anti-Angiogenic Potential: Network Pharmacology, Molecular Docking Prediction with ADMET Analysis and CAM Assay Visualization This study investigated the anti-angiogenic potential of Imperata cylindrica (cogon grass) leaf extract through an integrated network pharmacology–guided in silico approach coupled with in vivo validation, focusing on the multi-target behavior of its bioactive compounds. Given the central role of angiogenesis in tumor growth and metastasis, identifying plant-derived compounds capable of modulating angiogenic pathways remains a strategic priority in cancer research. Imperata ; In silico ; Docking (animal) ; Angiogenesis ; In vivo ; Cancer therapy Wood and Agarwood Research ; Bioactive Compounds in Plants ; Biological Stains and Phytochemicals
Authors: Andre Pointner | Daniela Thalheim | Sarah Belasi | Laura Heinen | L. R. Carnell | Christina Janko | Rainer Tietze | Christoph Alexiou | Regine Schneider‐Stock | Roland Nagy
Source: Advanced Materials Technologies (article, 2026-03-25)
Field: Materials Science — Materials Chemistry

A Compact Incubation Platform for Long‐Term Cultivation of Biological Samples for Nitrogen‐Vacancy Center Widefield Microscopy ABSTRACT Nitrogen‐vacancy (NV) centers in diamond provide a versatile quantum sensing platform for biological imaging through magnetic field detection, offering unlimited photostability and the ability to perform long‐term observations without photobleaching or phototoxicity. However, conventional stage‐top incubators are incompatible with the unique requirements for NV widefield magnetometry to study cellular dynamics. Here, we present a purpose‐built compact incubation platform that maintains precise environmental control of temperature, atmosphere, and humidity while accommodating the complex constraints of NV widefield microscopy. The system employs a 3D‐printed biocompatible chamber with integrated heating elements, temperature control, and humidified gas flow to create a stable physiological environment directly on the diamond sensing surface. We demonstrate sustained viability and proliferation of HT29 colorectal cancer cells over 90 hours of continuous incubation, with successful magnetic field imaging of immunomagnetically labeled cells after extended cultivation periods. This incubation platform enables long‐term cultivation and real‐time monitoring of biological samples on NV widefield magnetometry platforms, opening new possibilities for studying dynamic cellular processes using quantum sensing technologies. Magnetometer ; Magnetic field ; Quantum dot ; Biomagnetism ; Photobleaching ; Biocompatible material ; Microscopy ; Diamond Diamond and Carbon-based Materials Research ; Geomagnetism and Paleomagnetism Studies ; Magnetic Field Sensors Techniques
Authors: Ahmed Mortada | Alaa Y. Darwesh | Iman E. Taha | Thirupathi R. Anekalla | Nourhan Mostafa | Mohammed Maniruzzaman
Source: AAPS PharmSciTech (article, 2026-03-17)
Field: Materials Science — Surfaces, Coatings and Films

Personalized 3D-Printed Finger Splints Derived from CT Data Incorporating Multi-Drug Bilayer Nanofiber Delivery Systems Finger fractures are among the most common musculoskeletal injuries, yet conventional splints for finger are often poorly fitted, uncomfortable, and incapable of providing localized therapeutic support, which can delay healing and increase complications. This study presents a computed tomography (CT)-guided, patient-specific 3D-printed finger splint incorporating a bilayer electrospun nanofiber coating mat for localized dual delivery of hydrocortisone (HCT) and ibuprofen (IBU), providing concurrent anti-inflammatory and analgesic therapy through two distinct mechanisms. CT data were segmented to generate customized splint geometries, which were fabricated using fused deposition modeling (FDM) to produce a rigid polylactic acid outer shell and stereolithography (SLA) to create a flexible inner layer. The inner surface was sequentially coated with IBU-loaded polycaprolactone nanofibers then HCT-loaded pullulan. Comprehensive characterization by SEM, FTIR, DSC, and XRD confirmed smooth, bead-free PCL nanofibers, strong adhesion to the microtextured SLA surface, and amorphous dispersion of both drugs with entrapment efficiencies above 90%. In vitro release studies demonstrated rapid HCT liberation of 79.68 ± 0.17% within 2 h, and IBU release of 51.75 ± 4.35% within 24 h. Ex vivo porcine skin permeation studies showed significantly enhanced drug delivery compared with pure drug controls, with cumulative permeation values of 155.52 ± 19.97 µg/cm<sup>2</sup> for ibuprofen and 74.38 ± 2.18 µg/cm<sup>2</sup> for hydrocortisone at 24 h. These findings demonstrate the feasibility of CT-based personalized finger splints that integrate structural support with localized multidrug delivery, highlighting a promising platform for next generation, patient-tailored fracture management. Polycaprolactone ; Splints ; Bilayer ; Drug delivery ; Stereolithography ; Lornoxicam ; Nanofiber ; Ibuprofen Polymer Surface Interaction Studies ; Electrospun Nanofibers in Biomedical Applications ; 3D Printing in Biomedical Research
Authors: Janardhana Nayak | Jyothi Kudva
Source: Asian Journal of Chemistry (article, 2026-01-31)
Field: Chemistry — Organic Chemistry

Synthesis, Antimicrobial and DFT Studies of 1,3,4-Oxadiazole Linked Quinoline Carbaldehyde Derivatives A novel series of oxadiazole‑linked quinoline derivatives was synthesized and evaluated for antimicrobial activity and electronic properties. The synthetic pathway involved the preparation of 4‑substituted benzohydrazides, subsequent cyclization to yield 5‑(4‑substituted phenyl)‑1,3,4‑oxadiazole‑2‑thiols, and their coupling with 6/8‑substituted‑2‑chloroquinoline‑3‑carbaldehydes to obtain the target compounds viz. 2-((5-(4-substituted phenyl)-1,3,4-oxadiazol-2-yl)thio)-6/8-substituted quinoline-3-carbaldehydes (7a-l) in moderate to good yields. Antibacterial activity was assessed against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa, while antifungal activity was evaluated against Candida albicans using minimum inhibitory concentration (MIC) methods. Most compounds exhibited promising antimicrobial activity. Notably, compounds 7g and 7k, bearing p‑nitro phenyl substitution on the oxadiazole ring and chloro substitution on the quinoline nucleus, showed superior antibacterial and antifungal activities comparable to standard drugs. Quinoline ; Antimicrobial ; Bacillus subtilis ; Candida albicans ; Escherichia coli ; Antibacterial activity ; Oxadiazole ; Yield (engineering) Synthesis and biological activity ; Structural and Chemical Analysis of Organic and Inorganic Compounds ; Multicomponent Synthesis of Heterocycles
Authors: Ved Prakash Arya | Alok Kumar Maurya | Nitesh Jaiswal
Source: Asian Journal of Chemistry (article, 2026-04-08)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Synthesis, Characterisation, Computational Studies and Nonlinear Optical Properties of Cu(II), Ni(II) and Co(II) Complexes with 2-Hydroxynaphthaldehyde and 2,4-Dimethylaniline Derived Schiff Base Ligands A series of transition metal complexes derived from 2-hydroxynaphthaldehyde based Schiff base ligand designed and synthesised. The Schiff base ligand 1 was prepared via condensation of 2-hydroxy-1-naphthaldehyde with 2,4-dimethylaniline. The corresponding complexes 2-4 of Cu(II), Ni(II) and Co(II) ions were synthesised using Schiff base ligand in 1:2 molar ratios. The synthesised ligand and its metal(II) complexes were characterised using elemental analysis, UV-Vis, FT-IR, 1H NMR and mass spectrometry. Density functional theory (DFT) calculations at the B3LYP level with a basis set of 6-31G(d,p) were employed to optimize geometries, predict frontier molecular orbitals, compute HOMO–LUMO gaps and analyse electronic distribution. Non-liner optical properties of ligand and metal(II) complexes also computed using DFT method. The combined experimental and theoretical results suggest tetrahedral geometry in complex 2 and square-planar geometry in complexes 3 and 4. Schiff base ; Ligand (biochemistry) ; Tetrahedral molecular geometry ; Density functional theory ; Nonlinear optical ; Basis set ; Metal ; Tetrahedron ; Condensation Nonlinear Optical Materials Research ; Nonlinear Optical Materials Studies ; Metal complexes synthesis and properties
Authors: Najat Abdullah Masood | Hesham Hussein Rassem | Sami M. Magam | Anbia Adam | Gehad M. Subaiea | Tahani Y. Alanazi | Esam Omar Al-Wesabi | Ayshah Aysh ALrashidi
Source: Journal of King Saud University - Science (article, 2026-04-11)
Field: Chemistry — Organic Chemistry

Kinetic evaluation of the microwave-assisted hydrodistillation process for 2-phenylthiolane extraction from jasmine flowers Microwave-assisted hydrodistillation (MAHD) presents an effective substitute to traditional extraction techniques in the isolation of bioactive compounds from plant materials. However, limited kinetic data exist on the extraction behavior of 2-phenylthiolane from jasmine flowers using MAHD, and the underlying mass-transfer mechanisms remain insufficiently explored. This work investigates the kinetic models of 2-phenylthiolane extraction from jasmine blossoms using MAHD under varying conditions of time, microwave power levels, and solid-to-liquid ratios. Among the models examined, the second-order kinetic model had the highest accuracy (R 2 = 0.976), outperforming the first-order model and providing the best description of the two distinct extraction stages the rapid washing phase and the slower diffusion phase. Optimal extraction conditions were observed at 400 W microwave power and a solid-to-liquid ratio of 1.5 g/20 mL. The findings from this study show that following the second-order kinetic model, 2-phenylthiolane extraction can be precisely regulated, scaled up for industrial production, and the product quality and yield can be monitored and controlled for pharmaceutical applications. The study also contributes to advancing economical and environmentally friendly production techniques. All things considered, this model provides a strong basis for developing bioactive component extraction via MAHD, stimulating green technology innovation, and improving the economic feasibility of natural product recovery. Extraction (chemistry) ; Yield (engineering) ; Process (computing) ; Microwave power ; Product (mathematics) ; Diffusion ; Work (physics) ; Production (economics) Microwave-Assisted Synthesis and Applications ; Phytochemicals and Antioxidant Activities ; Plant chemical constituents analysis
Authors: Hiroyuki Miyachi | Masaki Koshimizu | Masashi Suzuki
Source: International Journal of Molecular Sciences (article, 2026-01-14)
Field: Chemistry — Organic Chemistry

On–DNA Platform Molecules Based on a Diazide Scaffold II: A Compact Diazide Platform Designed for Small–Molecule Drug Discovery Expanding the chemical diversity of DNA-encoded libraries (DELs) is crucial for identifying binders to emerging drug targets using DEL technology. In the present study, as part of our ongoing efforts to develop on-DNA diazide platforms (D-DAPs)-platform molecules possessing both aromatic and aliphatic azide groups on a single core reactive scaffold-we designed and synthesized a new compact diazide platform, designated as a compact D-DAP (C-D-DAP). This molecule is based on a low-molecular-weight reactive scaffold, 3-azido-5-(azidomethyl)benzoic acid, to facilitate small-molecule drug discovery targeting enzymes and G protein-coupled receptors (GPCRs). Furthermore, we established two distinct stepwise warhead construction strategies that exploit the chemoselective transformations of the azide groups in the C-D-DAP, which exhibit different reactivities. In addition, four virtual DELs were generated based on stepwise warhead elaboration from the C-D-DAP scaffold. Comparative chemical diversity analysis against bioactive compounds from ChEMBL revealed that these virtual libraries populate structural regions that are sparsely represented among known molecules. Each virtual library also occupies a distinct region of structural space relative to the others and displays intermediate quantitative estimate of drug-likeness (QED) values. Chemical space ; chEMBL ; Drug discovery ; Azide ; Cheminformatics ; Small molecule ; Virtual screening Click Chemistry and Applications ; Chemical Synthesis and Analysis ; Protein Degradation and Inhibitors
Authors: A. F. M. Mustafizur Rahman | Xiaoyan Zhou | Saad Farooqi | Xiangzhen Zhou | Yang Jiao | Sen Gu | Qingman Li
Source: Frontiers in Environmental Science (article, 2026-04-09)
Field: Materials Science — Biomaterials

Influence of amorphous silica on potassium immobilization in agricultural soils of the Jianghan Plain, China Potassium (K + ) fertilization is essential for crop production, yet its efficacy is often hindered by rapid soil fixation. Traditionally, this fixation is attributed to the interlayer spaces of 2:1-type clay minerals. However, emerging evidence suggests that amorphous silica (ASi) significantly influences soil nutrient dynamics. This study investigated the relationship between soil ASi fractions and K + pools in the agricultural soils (n = 49) of the Jianghan Plain, China. We operationally fractionated ASi into exchangeable (ASi exch ), active (ASi active ), non-active (ASi n-active ), and biogenic (BSi) fractions and quantified their associated K + pools (K + exch , K + active , K + n-active , and BK + ). Results demonstrated that all ASi fractions were significantly correlated with their corresponding K + pools (p &amp;lt; 0.05). The cumulative K + associated with ASi fractions (1.45 ± 0.23 g kg -1 ) significantly exceeded the conventionally defined readily available and slow-available K + pools, suggesting that current agronomic assessments may underestimate soil K + fertility. The strength of correlations between the associated K + and ASi followed the order: ASi exch &amp;gt; ASi active &amp;gt; ASi n-active &amp;gt; BSi. Furthermore, Strong positive correlations (r = 0.81–0.94, p &amp;lt; 0.001) were observed bewteen ASi active , ASi n-active , and Fe/Al, suggesting that these metal oxides are key mediators in K + -ASi interactions. Dynamic extraction revealed sustained co-release of Si and K + , with cumulative K + extraction reaching up to 17.5% of total K, while X-ray diffraction analysis confirmed minimal alteration of crystalline K-bearing minerals, indicating that K + release primarily originated from amorphous phases. The findings demonstrate ASi constitutes a substantial, previously underappreciated reservoir of labile K + in agricultural soils, with its liberation kinetics governed by synergistic interactions with Fe/Al oxides. Potassium ; Soil water ; Extraction (chemistry) ; Nutrient ; Amorphous solid ; Soil test ; Metal Clay minerals and soil interactions ; Silicon Effects in Agriculture ; Mesoporous Materials and Catalysis
Authors: S. Renukadevi | B. Deepan Kumar | G. Hari Hara Priya | T. Tamizharuvi | V. Jaisankar
Source: Asian Journal of Chemistry (article, 2026-04-08)
Field: Materials Science — Biomaterials

Synthesis and Characterisation of β-Cyclodextrin-Conjugated Carboxymethyl Chitosan Derivative for Antimicrobial and Wound Healing Applications Chitosan can be chemically modified to form a range of derivatives to perform enhanced biological activities with enhanced solubility in water and functional properties. These alterations have tunned their applications towards biomedical fields. This work aims to synthesize the carboxymethyl derivative of chitosan selectively functionalised at the C6 carbon atom through careful masking of the C2 location. In this regard, the C2-amino group was shielded to avoid interfering with the carboxymethylation process at the C6 hydroxyl group. The functional characteristics of the chitosan derivative were further improved by conjugating it with β-cyclodextrin to form a β-cyclodextrin-carboxymethyl chitosan (CD-CMCh) derivative. Further biological potential was tested on the derivative emphasizing its significant activity against the bacteria S. aureus (13 ± 2 mm), E. coli (9 ± 1 mm) and K. pnemoniae (11 ± 2 mm) at the concentration of 1000 µg/mL, along with the potent activity against fungal A. niger (19 ± 5.7 mm, 16.37 ± 7.6 mm) and T. viride (13.3 ± 3.5 mm, 12.7 ± 5 mm) at the concentration 1000 and 500 µg/mL, respectively than C. albicans. Furthermore, the in vitro wound healing assay revealed a 65% wound closure, indicating substantial cell migration and regenerative potential. Results revealed that this selectively modified derivative is a flexible molecule in the production of biomedical materials and thus holds great promise for application in antimicrobial treatments and wound healing therapy. Chitosan ; Antimicrobial ; Wound healing ; Derivative (finance) ; Solubility ; In vitro ; Biological activity Nanocomposite Films for Food Packaging ; Advanced Drug Delivery Systems ; Hydrogels: synthesis, properties, applications
Authors: Heba A. El-Refai | Sanaa K. Gomaa | Rania A. Zaki | Samah M. El-Sayed | Hoda S. El-Sayed | Youssef R. Hassan | Abdelmonem Elrefaey | M. E. Abd El-Aziz
Source: Scientific Reports (article, 2026-04-04)
Field: Materials Science — Biomaterials

Preparation of starch/PVA/Cu-NPs bio-nanocomposites in packing as preservation of UF soft cheese This study represents the biosynthesis of copper oxide nanoparticles (CuO-NPs) via bacteria and their utilization in the synthesis of a bio-nanocomposite based on starch (St) and polyvinyl alcohol (PVA) to be applied in preserving ultrafiltration (UF) soft cheese. The bio-nanocomposites were synthesized by blending St/PVA with a ratio of 4:1 wt, wt and loaded with various concentrations of CuO-NPs (0, 20, 40, and 80 mg) to obtain bio-nanocomposite coatings S1, S2, S3, and S4, respectively. The coatings' mechanical strength, water and oxygen barrier quality, morphology, and crystallinity were all studied. The chemical composition, microbial load, total solids, and pH changes for uncoated and coated cheese samples that were stored at 5 ± 2 °C for 60 days were evaluated. Results showed that films loaded with CuO-NPs significantly improved the mechanical and barrier properties of the prepared films, in addition to reducing the moisture loss and microbial growth and extending the shelf life of the coated cheese. In addition, the bio-nanocomposite coating loaded with higher CuO-NP concentrations (S3 and S4) showed superior antimicrobial effects, indicating their potential as active edible coatings for cheese preservation. Polyvinyl alcohol ; Crystallinity ; Coating ; Antimicrobial ; Shelf life ; Ultrafiltration (renal) ; Starch ; Chitosan ; Moisture Nanocomposite Films for Food Packaging ; Advanced Cellulose Research Studies ; Nanoparticles: synthesis and applications
Authors: Ying Wang | Yawen Wang | Qihan Yuan | Jiaoyan Qiu | Jing Wang | Yuanfei Wang | Manfei Fu | Tong Wu
Source: Frontiers in Bioengineering and Biotechnology (article, 2026-02-26)
Field: Materials Science — Biomaterials

Fabrication and characterization of small-caliber nanofibrous vascular scaffolds with sustained release of endothelial cell derivatives and heparin This study proposed a new strategy for developing small-caliber vascular scaffolds with enhanced hemocompatibility and sustained anticoagulant activity. Nanofiber ; Thrombus ; Heparin ; Electrospinning ; Anticoagulant ; Scaffold ; Endothelial stem cell Electrospun Nanofibers in Biomedical Applications ; Coronary Interventions and Diagnostics ; 3D Printing in Biomedical Research
Authors: Spizhova Y.
Source: Universal library of medical and health sciences. (article, 2026-03-24)
Field: Chemistry — Organic Chemistry

Photopolymerization of Gels: Curing Kinetics and Degree of Conversion as Predictors of Biocompatibility Within the scope of the study, an in-depth analysis was conducted of the physicochemical regularities governing the photopolymerization of methacrylate systems used in contemporary nail-service practice, with particular emphasis on identifying cause-and-effect relationships between the degree of chemical conversion and the biological safety parameters of the resulting coatings. The key aspects of radical polymerization are presented in a consistent sequence, and it is shown how the spectral characteristics of current LED sources determine initiation efficiency and the ultimate curing depth of the material. Reaction completeness control is described through analytical approaches based on infrared spectroscopy (FTIR), which enables quantitative assessment of the reduction in the fraction of reactive groups and, by doing so, objectifies the degree of conversion. A separate semantic emphasis is placed on the migration of residual low-molecular-weight components, primarily 2-hydroxyethyl methacrylate (HEMA), as a critical factor shaping the toxicological profile. In parallel, the regulatory shifts of 2025 are considered, including the ban on the photoinitiator TPO within the Omnibus VII package, which necessitates revision of traditional solutions in the area of photoinitiation and formulation design. As a result of the analysis, it is demonstrated that achieving a degree of conversion above 75–80% functions as a principled condition for lowering the likelihood of allergic contact dermatitis and reducing the risk of systemic sensitization, because insufficient conversion correlates with an increased fraction of migratory monomers and oligomeric fragments. The formulated conclusions support the advisability of transitioning to updated initiation systems and substantiate the introduction of hybrid organic–inorganic materials as a technological direction capable of simultaneously increasing curing efficiency and stabilizing the composition after polymerization. The materials presented have applied significance for nail-service practice, dermatological assessment, cosmetic formulation development, and certification-oriented evaluation procedures aimed at improving safety levels within the beauty industry. Photoinitiator ; Photopolymer ; Curing (chemistry) ; Polymerization ; Methacrylate ; Monomer ; Biocompatibility ; Homogeneous ; Degree of polymerization Photopolymerization techniques and applications ; Skin Protection and Aging ; Surgical Sutures and Adhesives