jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Zhangxiong Wu | Kathryn Waldron | Xiangcheng Zhang | Yunqing Li | Lei Wu | Winston Duo Wu | Xiao Dong Chen | Dongyuan Zhao | Cordelia Selomulya
Source: Journal of Colloid and Interface Science (article, 2019-08-24)
Field: Materials Science — Materials Chemistry

Spray-drying water-based assembly of hierarchical and ordered mesoporous silica microparticles with enhanced pore accessibility for efficient bio-adsorption Mesoporous material ; Chemical engineering ; Polymer ; Materials science ; Mesoporous silica ; Nanoparticle ; Colloid ; Calcination ; Porosity ; Adsorption ; Micelle ; Evaporation ; Copolymer ; Spray drying ; Self-assembly ; Nanotechnology ; Chemistry ; Organic chemistry ; Catalysis ; Composite material Mesoporous Materials and Catalysis ; Analytical Chemistry and Chromatography ; Aerogels and thermal insulation
Authors: Alaine Maria dos Santos Silva | Lilia Basílio de Caland | Ednaldo Gomes do Nascimento | Ana Luíza C. de S. L. Oliveira | Raimundo F. de Araújo-Júnior | Alianda Maira Cornélio | Matheus de Freitas Fernandes‐Pedrosa | Arnóbio Antônio da Silva-Júnior
Source: International Journal of Molecular Sciences (article, 2019-05-11)
Field: Materials Science — Biomaterials

Self-Assembled Benznidazole-Loaded Cationic Nanoparticles Containing Cholesterol/Sialic Acid: Physicochemical Properties, In Vitro Drug Release and In Vitro Anticancer Efficacy Cationic polymeric nanoparticles (NPs) have the ability to overcome biological membranes, leading to improved efficacy of anticancer drugs. The modulation of the particle-cell interaction is desired to control this effect and avoid toxicity to normal cells. In this study, we explored the surface functionalization of cationic polymethylmethacrylate (PMMA) NPs with two natural compounds, sialic acid (SA) and cholesterol (Chol). The performance of benznidazole (BNZ) was assessed in vitro in the normal renal cell line (HEK-293) and three human cancer cell lines, as follows: human colorectal cancer (HT-29), human cervical carcinoma (HeLa), and human hepatocyte carcinoma (HepG2). The structural properties and feasibility of NPs were evaluated and the changes induced by SA and Chol were determined by using multiple analytical approaches. Small (<200 nm) spherical NPs, with a narrow size distribution and high drug-loading efficiency were prepared by using a simple and reproducible emulsification solvent evaporation method. The drug interactions in the different self-assembled NPs were assessed by using Fourier transform-infrared spectroscopy. All formulations exhibited a slow drug-release profile and physical stability for more than 6 weeks. Both SA and Chol changed the kinetic properties of NPs and the anticancer efficacy. The feasibility and potential of SA/Chol-functionalized NPs has been demonstrated in vitro in the HEK-293, HepG2, HeLa, and HT-29 cell lines as a promising system for the delivery of BNZ. In vitro ; Chemistry ; Drug ; Pharmacology ; Benznidazole ; Nanoparticle ; Cationic polymerization ; Biochemistry ; Nanotechnology ; Medicine ; Materials science ; Organic chemistry Nanoparticle-Based Drug Delivery ; RNA Interference and Gene Delivery ; Advanced Drug Delivery Systems
Authors: Behrouz Bayati | Asma Ghorbani | Kamran Ghasemzadeh | Adolfo Iulianelli | Angelo Basile
Source: Molecules (article, 2019-11-28)
Field: Chemistry — Inorganic Chemistry

Study on the Separation of H2 from CO2 Using a ZIF-8 Membrane by Molecular Simulation and Maxwell-Stefan Model The purification of H<sub>2</sub>-rich streams using membranes represents an important separation process, particularly important in the viewpoint of pre-combustion CO<sub>2</sub> capture. In this study, the separation of H<sub>2</sub> from a mixture containing H<sub>2</sub> and CO<sub>2</sub> using a zeolitic imidazolate framework (ZIF)-8 membrane is proposed from a theoretical point of view. For this purpose, the adsorption and diffusion coefficients of H<sub>2</sub> and CO<sub>2</sub> were considered by molecular simulation. The adsorption of these gases followed the Langmuir model, and the diffusion coefficient of H<sub>2</sub> was much higher than that of CO<sub>2</sub>. Then, using the Maxwell-Stefan model, the H<sub>2</sub> and CO<sub>2</sub> permeances and H<sub>2</sub>/CO<sub>2</sub> permselectivities in the H<sub>2</sub>-CO<sub>2</sub> mixtures were evaluated. Despite the fact that adsorption of CO<sub>2</sub> was higher than H<sub>2</sub>, owing to the simultaneous interference of adsorption and diffusion processes in the membrane, H<sub>2</sub> permeation was more pronounced than CO<sub>2</sub>. The modeling results showed that, for a ZIF-8 membrane, the H<sub>2</sub>/CO<sub>2</sub> permselectivity for the H<sub>2</sub>-CO<sub>2</sub> binary mixture 80/20 ranges between 28 and 32 at ambient temperature. Membrane ; Adsorption ; Chemistry ; Permeation ; Diffusion ; Thermodynamics ; Simulated moving bed ; Langmuir adsorption model ; Chromatography ; Gas separation ; Chemical engineering ; Langmuir ; Physical chemistry Metal-Organic Frameworks: Synthesis and Applications ; Membrane Separation and Gas Transport ; Carbon Dioxide Capture Technologies
Authors: Rika Wijiyanti | Triyanda Gunawan | Noor Shawal Nasri | Zulhairun Abdul Karim | Ahmad Fauzi Ismail | Nurul Widiastuti
Source: Indonesian Journal of Chemistry (article, 2019-12-31)
Field: Chemistry — Inorganic Chemistry

Hydrogen Adsorption Characteristics for Zeolite-Y Templated Carbon The hydrogen adsorption, kinetic and thermodynamic of adsorption onto the zeolite templated carbon (ZTC) were examined at the temperature range of 30-50 °C and ambient pressure. The ZTC was prepared from zeolite-Y template and sucrose carbon precursor by impregnation method and showed its specific surface area of 932 m2/g as well as 0.97 cm3/g for total pore volume. Analysis of physical and chemical characteristics for materials were performed using XRD, SEM, TEM and N2 isotherm. The results indicated that the ZTC has some ordered network structure of carbon and also exhibits the formation of carbon layer outside the zeolite micropore. We observed the ZTC for hydrogen adsorption both gravimetric and volumetric method up to 1.72 and 1.16 wt.% at the lowest temperature, respectively. The kinetic process at all studied temperature was best approximated by pseudo second order kinetic model. The aspects of thermodynamic such as heat of adsorption and the entropy change were -14.41 kJ/mol and -40.93 J/K mol, respectively. Both values was negative, indicating an exothermic reaction and low disorder at the hydrogen and ZTC interface, when the adsorption process took place. While, the enthalpy change value exhibits characteristic of physical process. The Gibbs energy change calculated at 30, 40 and 50 °C were -1.99, -1.59 and -1.19 kJ/mol, respectively, indicating a spontaneous adsorption process. Adsorption ; Zeolite ; Enthalpy ; Chemistry ; Gravimetric analysis ; Exothermic reaction ; Hydrogen ; Microporous material ; Gibbs free energy ; Carbon fibers ; Thermodynamics ; Exothermic process ; Physical chemistry ; Catalysis ; Organic chemistry ; Materials science Zeolite Catalysis and Synthesis ; Advanced NMR Techniques and Applications ; Hydrogen Storage and Materials
Authors: Fabian Könemann | Morten Vollmann | Tino Wagner | Norizzawati Mohd Ghazali | Tomohiro Yamaguchi | Andreas Stemmer | Koji Ishibashi | Bernd Gotsmann
Source: The Journal of Physical Chemistry C (article, 2019-04-19)
Field: Materials Science — Materials Chemistry

Thermal Conductivity of a Supported Multiwalled Carbon Nanotube We have extracted temperature-dependent thermal conductivity values from scanning thermal microscopy measurements of a self-heated multiwalled carbon nanotube supported on a silicon substrate. A deliberately introduced segment of amorphous carbon served as an integrated nanoheater. Kelvin probe force microscopy was used to supplement the thermometry data with values for the nanotube’s electrical resistivity. This way, both the spatially resolved temperature rise and the Joule heating power density were available for further analysis. A one-dimensional heat diffusion model was fitted to the data to extract values for the thermal conductivity along the nanotube axis and the thermal conductance between the nanotube and supporting substrate. We found thermal conductivity values that continuously increase from 200 to 400 W m–1 K–1 in a temperature range of 100 to 400 K above room temperature. The values obtained are about one order of magnitude lower compared to values reported for the freely suspended case. We attribute this observation to the increased phonon scattering and quenching of acoustic phonon modes due to the substrate interaction. Nanotube ; Materials science ; Thermal conductivity ; Carbon nanotube ; Conductivity ; Nanotechnology ; Chemical engineering ; Composite material ; Chemistry ; Physical chemistry ; Engineering Carbon Nanotubes in Composites ; Thermal properties of materials ; Graphene research and applications
Authors: María N. Chao | M. Victoria Lorenzo Ocampo | Sergio H. Szajnman | Roberto Docampo | Juan B. Rodríguez
Source: Bioorganic & Medicinal Chemistry (article, 2019-02-19)
Field: Chemistry — Organic Chemistry

Further insights of selenium-containing analogues of WC-9 against Trypanosoma cruzi Trypanosoma cruzi ; Chemistry ; Moiety ; Chagas disease ; Antiparasitic ; Stereochemistry ; Selenium ; Biological activity ; Benznidazole ; Structure–activity relationship ; Combinatorial chemistry ; Antiparasitic agent ; Biochemistry ; In vitro ; Pharmacology ; Organic chemistry ; Virology ; Biology Synthesis and Biological Evaluation ; Cyclopropane Reaction Mechanisms ; Trypanosoma species research and implications
Authors: Do-Gak Jeung | Hyoung-Jun Kim | Jae‐Min Oh
Source: Nanomaterials (article, 2019-09-05)
Field: Materials Science — Materials Chemistry

Incorporation of Glycine max Merrill Extract into Layered Double Hydroxide through Ion-Exchange and Reconstruction We incorporated extract of <i>Glycine max Merrill</i> (GM), which is generally known as soybean, into a layered double hydroxide (LDH) nanostructure through two different methods, ion-exchange and reconstruction. Through X-ray diffraction, field-emission scanning electron microscopy, and zeta-potential measurement, GM moiety seemed to be simply attached on the surface of LDH by ion-exchange process, while the extract could be incorporated in the inter-particle pore of LDHs by reconstruction reaction. The quantification exhibited that both incorporation method showed comparable extract loading capacity of 15.6 wt/wt% for GM-LDH hybrid prepared by ion-exchange (GML-I) and 18.6 wt/wt% for GM-LDH hybrid by reconstruction (GML-R). On the other hand, bioactive substance in both GM-LDH hybrids, revealed that GML-R has higher daidzein content (0.0286 wt/wt%) compared with GML-I (0.0108 wt/wt%). According to time-dependent daidzein release, we confirmed that GML-R showed pH dependent daidzein release; a higher amount of daidzein was released in pH 4.5 physiological condition than in pH 7.4, suggesting the drug delivery potential of GML-R. Furthermore, alkaline phosphatase activity and collagen fiber formation on human osteoblast-like MG-63 cells displayed that GML-R had superior possibility of osteoblast differentiation than GML-I. From these results, we concluded that reconstruction method was more effective for extract incorporation than ion-exchange reaction, due to its pH dependent release property and alkaline phosphatase activity. Hydroxide ; Chemistry ; Alkaline phosphatase ; Ion exchange ; Osteoblast ; Glycine ; Nuclear chemistry ; Chromatography ; Ion ; Biochemistry ; Inorganic chemistry ; Organic chemistry ; Enzyme Layered Double Hydroxides Synthesis and Applications ; Inorganic Chemistry and Materials ; Magnesium Oxide Properties and Applications
Authors: Haotian Sun | Lingyue Yan | Michael Y. Chang | Kevin A. Carter | Runsheng Zhang | Leigh Slyker | Jonathan F. Lovell | Yun Wu | Chong Cheng
Source: Nanoscale Advances (article, 2019-01-01)
Field: Materials Science — Biomaterials

A multifunctional biodegradable brush polymer-drug conjugate for paclitaxel/gemcitabine co-delivery and tumor imaging A multifunctional biodegradable brush polymer-drug conjugate (BPDC) is developed for the co-delivery of hydrophobic paclitaxel (PTX) and hydrophilic gemcitabine (GEM) chemotherapeutics, as well as a tumor imaging agent. A novel ternary copolymer of conventional, acetylenyl-functionalized and allyl-functionalized lactides is prepared to serve as the backbone precursor of BPDC. Acetylenyl groups of the copolymer are then reacted with poly(ethylene glycol) (PEG) side chains and cyanine5.5, a fluorescent probe, <i>via</i> azide-alkyne click reactions. Subsequently, the allyl groups of the yielded PEG-grafted brush polymer are used to covalently link PTX and GEM onto the backbone <i>via</i> thiol-ene click reactions. The resulting BPDC exhibits an average hydrodynamic diameter of 111 nm. Sustained and simultaneous release of PTX and GEM from the BPDC is observed in phosphate buffered saline, with the release of PTX showing sensitivity in mild acidic conditions. <i>In vitro</i> studies using MIA PaCa-2 human pancreatic cancer cells illustrate the cellular uptake and cytotoxicity of the BPDC. <i>In vivo</i>, the BPDC possesses long blood circulation, tumor accumulation, and enables optical tumor imaging. Further development and testing is warranted for multifunctional conjugated brush polymer systems that integrate combination chemotherapies and imaging. Paclitaxel ; Gemcitabine ; Brush ; Conjugate ; Drug delivery ; Drug ; Nanotechnology ; Materials science ; Pharmacology ; Medicine ; Surgery ; Chemotherapy Nanoparticle-Based Drug Delivery ; Nanoplatforms for cancer theranostics ; Lanthanide and Transition Metal Complexes
Authors: Guochao Shi | Mingli Wang | Yanying Zhu | Yuhong Wang | Xiaoya Yan | Xin Sun | Haijun Xu | Wanli Ma
Source: Beilstein Journal of Nanotechnology (article, 2019-02-28)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Biomimetic synthesis of Ag-coated glasswing butterfly arrays as ultra-sensitive SERS substrates for efficient trace detection of pesticides In this work, we report a biomimetic synthesis route of 3D Ag nanofilm/glasswing butterfly wing hybrids (Ag-G.b.) by magnetron sputtering technology. The 3D surface-enhanced Raman scattering (SERS) substrate is fabricated from an original chitin-based nanostructure, which serves as a bio-scaffold for Ag nanofilms to be coated on. The novel crisscrossing plate-like nanostructures of 3D Ag-G.b. nanohybrids with thick Ag nanofilms provide a substantial contribution to SERS enhancement. Measuring the SERS performance with crystal violet (CV), the Ag-G.b. nanohybrids with the sputtering time of 20 min (Ag-G.b.-20) shows the highest enhancement performance with an enhancement factor (EF) of up to 2.96 × 10<sup>7</sup>. The limit of detection (LOD) for CV was as low as 10<sup>-11</sup> M, demonstrating the ultrahigh sensitivity of the Ag-G.b.-20 substrate. In addition, the Ag-G.b.-20 substrate has an outstanding reproducibility across the entire area with the maximum value of relative standard deviation (RSD) of less than 10.78%. The nanohybrids also exhibit a long-term stability regarding Raman enhancement, as suggested by a duration stability test over a period of 60 days. Importantly, the high-performance Ag-G.b.-20 substrate is further applied as an ultra-sensitive SERS platform for the trace detection of acephate, showing its great potential application in biochemical sensing and food security. Materials science ; Substrate (aquarium) ; Detection limit ; Raman scattering ; Crystal violet ; Nanostructure ; Nanotechnology ; Raman spectroscopy ; Silver nanoparticle ; Sputtering ; Surface-enhanced Raman spectroscopy ; Sputter deposition ; Nanoparticle ; Chemistry ; Thin film ; Chromatography ; Optics Gold and Silver Nanoparticles Synthesis and Applications ; Quantum Dots Synthesis And Properties ; Plasmonic and Surface Plasmon Research
Authors: Xuemeng Wang | Yu Li | Tingjuan Wu | Zhigang Yang | Xing Zheng | Shizhen Chen | Xin Zhou | Zhong‐Xing Jiang
Source: Biomacromolecules (article, 2019-12-23)
Field: Materials Science — Biomaterials

Quantitatively Fine-Tuning the Physicochemical and Biological Properties of Peptidic Polymers through Monodisperse PEGylation In biomedicine, PEGylation is one of the most successful strategies to modify the physicochemical and biological properties of peptides, proteins, and other biomacromolecules. Because of the polydisperse nature of regular PEGs and limited PEGylation strategies, it is challenging to quantitatively fine-tune and accurately predict the properties of biomacromolecules after PEGylation. However, such fine-tuning and prediction may be crucial for their biomedical applications. Herein, some monodisperse PEGylation strategies, including backbone PEGylation, side-chain PEGylation, and highly branched PEGylation, have been developed. In a comparative fashion, the impact of PEGylation strategies and monodisperse PEG sizes on the physicochemical and biological properties, including lipophilicity, thermosensitivity, biocompatibility, plasma stability, and drug delivery capability, of peptidic polymers has been quantitatively studied. It was found that the physicochemical and biological properties of PEGylated peptidic polymers can be quantitatively fine-tuned and accurately predicted through these monodisperse PEGylation strategies. After the comparative study, a side-chain monodisperse PEGylated peptidic polymer was chosen as fluorine-19 magnetic resonance and fluorescence dual-imaging traceable drug delivery vehicle. Our study may not only promote the transformation of PEGylation from an empirical technology to a quantitative science but also shed light on the rational design of PEGylated biomaterials and pharmaceutics. PEGylation ; Dispersity ; Chemistry ; Drug delivery ; Polymer ; Nanotechnology ; Materials science ; Organic chemistry ; Polyethylene glycol Supramolecular Self-Assembly in Materials ; Nanoplatforms for cancer theranostics ; Graphene and Nanomaterials Applications
Authors: Yaguo Yu | Wei Xu | Yanyan Fu | Huimin Cao | Qingguo He | Jiangong Cheng
Source: Dyes and Pigments (article, 2019-08-30)
Field: Materials Science — Materials Chemistry

Receptor fluoride fine-tuning of fluorescent polymer probe for highly sensitive fluorescence response of methamphetamine vapor Fluorescence ; Conjugated system ; Detection limit ; Polymer ; Selectivity ; Quantum yield ; Quenching (fluorescence) ; Chemistry ; Photochemistry ; Materials science ; Analytical Chemistry (journal) ; Organic chemistry ; Chromatography ; Catalysis Luminescence and Fluorescent Materials ; Molecular Sensors and Ion Detection ; Covalent Organic Framework Applications
Authors: Yang Zhao | Zhaoqi Ye | Hongbin Zhang | Yahong Zhang | Yi Tang
Source: Industrial & Engineering Chemistry Research (article, 2019-06-27)
Field: Chemistry — Inorganic Chemistry

Facile Fabrication and Morphology Regulation of Crossed MFI Zeolite with Improved Performance on LDPE Cracking Morphology and mesoporosity of zeolite are two vital properties to determine its performance in diverse applications involving catalysis, adsorption, and separation; therefore, synthesis of zeolite with exceptional morphology and architecture has attracted much attention in recent years. Herein, a crossed MFI zeolite is fabricated using a bifunctional surfactant as SDA, and the physical as well as chemical properties of it including mesoporosity, particle size, and Si/Al ratio are controllably regulated by fine-tuning the synthesis parameters, such as H2O/SiO2 and NaOH/SiO2 ratios. In addition, the catalytic performance of the harvested MFI zeolites with different morphologies is thoroughly studied by LDPE cracking reaction. The results declare that the activation energy of this reaction can be effectively reduced with the aid of crossed MFI zeolite so that the reaction activity is extremely enhanced. This work opens a bright road to tailor the properties and performance of zeolite solely by facilely altering its synthesis parameters. Zeolite ; Materials science ; Chemical engineering ; Bifunctional ; Catalysis ; Morphology (biology) ; Fabrication ; Adsorption ; Fluid catalytic cracking ; Cracking ; Nanotechnology ; Chemistry ; Organic chemistry ; Composite material Zeolite Catalysis and Synthesis ; Mesoporous Materials and Catalysis ; Chemical Synthesis and Characterization
Authors: Vidya Gopi | Saravanan Subbiahraj | Karthika Chemmanghattu | Praveen C. Ramamurthy
Source: Dyes and Pigments (article, 2019-09-16)
Field: Materials Science — Electronic, Optical and Magnetic Materials

2,3-di(2-furyl) quinoxaline bearing 3 -ethyl rhodanine and 1,3 indandione based heteroaromatic conjugated T-shaped push -pull chromophores: Design, synthesis, photophysical and non-linear optical investigations Quinoxaline ; Hyperpolarizability ; Chemistry ; Rhodanine ; Thiophene ; Conjugated system ; Sonogashira coupling ; Knoevenagel condensation ; Molecule ; Photochemistry ; Polymer ; Organic chemistry Nonlinear Optical Materials Research ; Nonlinear Optical Materials Studies ; Porphyrin and Phthalocyanine Chemistry
Authors: Francis Perton | Sébastien Harlepp | Gautier Follain | Ksenia Parkhomenko | Jacky G. Goetz | Sylvie Bégin‐Colin | Damien Mertz
Source: Journal of Colloid and Interface Science (article, 2019-01-24)
Field: Materials Science — Materials Chemistry

Wrapped stellate silica nanocomposites as biocompatible luminescent nanoplatforms assessed in vivo Biocompatibility ; Nanotechnology ; Luminescence ; Materials science ; Coating ; Nanoparticle ; Aqueous solution ; Quantum dot ; Nanocomposite ; Chemical engineering ; Chemistry ; Organic chemistry Quantum Dots Synthesis And Properties ; Advanced biosensing and bioanalysis techniques ; Polymer Surface Interaction Studies
Authors: Julius Hillenbrand | Markus Leutzsch | Alois Fürstner
Source: Angewandte Chemie (article, 2019-08-26)
Field: Chemistry — Organic Chemistry

Molybdenum Alkylidyne Complexes with Tripodal Silanolate Ligands: The Next Generation of Alkyne Metathesis Catalysts Abstract A new type of molybdenum alkylidyne catalysts for alkyne metathesis is described, which is distinguished by an unconventional podand topology. These structurally well‐defined complexes are easy to make on scale and proved to be tolerant toward numerous functional groups; even certain protic substituents were found to be compatible. The new catalysts were characterized by X‐ray crystallography and by spectroscopic means, including 95 Mo NMR. Molybdenum ; Alkyne ; Metathesis ; Catalysis ; Chemistry ; Combinatorial chemistry ; Salt metathesis reaction ; Metallacycle ; Stereochemistry ; Organic chemistry ; X-ray crystallography ; Polymerization ; Physics Synthetic Organic Chemistry Methods ; Catalytic Alkyne Reactions ; Organometallic Complex Synthesis and Catalysis