jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Hao Wang | Yongquan Lin | Junjie Sun | Xin Wang | Hailong Yu | Kai Deng | Rong Zeng | Mingxuan He | Gang Tang | Congxi Tao
Source: Journal of Applied Polymer Science (article, 2025-02-14)
Field: Materials Science — Polymers and Plastics

Phytic Acid/Sodium Alginate Coating to Enhance Flame Retardancy of Rigid Polyurethane Foam: A Novel Strategy for Fire Safety ABSTRACT The precursor composed of phytic acid (PA) and sodium alginate (SA) was fabricated using the sol–gel technique and subsequently applied as a coating on the surface of rigid polyurethane foam (RPUF). PA/SA aerogel was obtained using freeze‐drying technology to enhance the fire resistance and flame‐retardant properties of the RPUF. Subsequent testing revealed that a 0.5 mm thick aerogel coating effectively enhances the flame retardancy of the composite. Limiting oxygen index (LOI) of the composites stands at an impressive 30.4 vol%, and it attains the V‐0 rating in UL‐94 vertical combustion testing. The Peak heat release rate (PHRR) measures 356.62 kW/m 2 , indicating a 27.60% reduction compared to that of pure RPUF. Thermogravimetric analysis shows a residual char residue of 20.78 wt%, representing a 52.46% increase compared to the pristine sample. Parameters such as the PHRR and fire growth index (FGI) exhibit significant reductions. This novel aerogel coating significantly enhances the fire safety of RPUF, effectively broadening applications of RPUF. Polyurethane ; Coating ; Materials science ; Phytic acid ; Composite material ; Fire retardant ; Sodium alginate ; Fire safety ; Chemical engineering ; Sodium ; Chemistry ; Food science ; Business Flame retardant materials and properties ; Polymer composites and self-healing ; Photopolymerization techniques and applications
Authors: K. Umapathi | M. Jayasheela | M. Ramya | J. K. Hari Sriram | G. Shibu | Eldho Paul | J. Yogitha | Maha Abdullah | C. Sushma | M. Manjupriya | S. Jerone Samuvel
Source: Discover Applied Sciences (article, 2025-06-06)
Field: Materials Science — Polymers and Plastics

Exploring the synthesis and biomedical potential of banana stem fiber for antimicrobial and wound healing applications Abstract Need for non-toxic materials especially for biomedical application remains the most important driving force for the discovery of nature-derived biomaterials. In particular, fibers and extracts from plants with medicinal value are vastly investigated. One such source is the banana fiber. The lignocellulosic and protein-based structures of banana fibers contribute to their biodegradability and biocompatibility, which are essential attributes for medical use. Despite their promising biocompatibility, banana fibers face challenges such as variability in their mechanical properties and limited raw state performance. This necessitates precise fiber synthesis and advanced processing to obtain biocompatible fibers for biomedical use. This review discusses the chemical constituents, extraction methods, characterization of natural fiber derived from banana pseudo stem, along with the antimicrobial and tissue regeneration potential of banana fiber based biomedical materials recently developed. Further, steps involved in the conversion of banana fiber to useful biomedical material are presented along with fabrication techniques. In addition, challenges and limitations that hurdle research progress, and potential for future biomaterials through functionalization are discussed. Review findings support potential for research intervention at the integration of banana fibers, biopolymers and nanotechnology towards development of efficient wound healing materials. Inherent to the comprehensive coverage of topics, the authors assure that this review will potentially act as a valuable source of information that could boost research and development of banana fiber-based wound healing biomaterials. Graphical Abstract Antimicrobial ; Wound healing ; Wound dressing ; Medicine ; Biology ; Materials science ; Microbiology ; Surgery ; Composite material Natural Fiber Reinforced Composites ; Nanocomposite Films for Food Packaging ; Advanced Cellulose Research Studies
Authors: C. Y. Chan | Lamiaa F. Alsalem | Mshaal Almalki | Irina Bozhinovska | James Hayward | Skip Williams | Jonathan K. Bartley
Source: Catalysts (article, 2025-07-24)
Field: Chemistry — Organic Chemistry

Microwave-Assisted Degradation of Azo Dyes Using NiO Catalysts Catalysts are ubiquitous in manufacturing industries and gas phase pollutant abatement but are not widely used in wastewater treatment, as high temperatures and concentrated waste streams are needed to achieve the reaction degradation rates required. Heating water is energy intensive, and alternative, low temperature solutions have been investigated, collectively known as advanced oxidation processes. However, many of these advanced oxidation processes use expensive oxidants such as perchlorate, hydroxy radicals or ozone to react with contaminants, and therefore have high running costs. This study has investigated microwave catalysis as a low-energy, low-cost technology for water treatment using NiO catalysts that can be heated in the microwave field to drive the decomposition of azo-dye contaminants. Using this methodology for the microwave-assisted degradation of two azo dyes (azorubine and methyl orange), conversions of &gt;95% were achieved in only 10 s with 100 W microwave power. Degradation (telecommunications) ; Non-blocking I/O ; Catalysis ; Chemical engineering ; Materials science ; Chemistry ; Photochemistry ; Computer science ; Organic chemistry ; Telecommunications Nanomaterials for catalytic reactions ; Microwave-Assisted Synthesis and Applications ; Catalytic Processes in Materials Science
Authors: Ali Reza Faraji | A. Gil | Alireza Farahanipour | Elisabeth Tehrani | N. Bakhshi Khoramdareh | E. Dashtabadi | S. Jafari | N. Shojaei | Z. Hekmatian | Saeedeh Saeedi
Source: Trends in Food Science & Technology (article, 2025-06-13)
Field: Materials Science — Materials Chemistry

Synergic removal of Aflatoxin B1 in oily matrices by focusing on the peroxidase-like nanozymes-driven strategies: Mechanisms and intermediate toxicity, nutritional impact, advances and challenges Oilseeds and extracted oils, as the supplier of at least 40% of calories, dietary essential fatty acids, and food flavor, due to insufficient cultivation-harvesting techniques, processing and long-term storage in improper conditions, and lack of adequate food-safety standards and/or official consideration, are prone to contamination by AFB1. Given its irreversible adverse effects on consumer health and food/feed safety due to various factors ( e.g., high chemical stability of lipophilic AFB1, transformation to other toxic derivatives, and chemical interaction with oily matrices), developing a decontamination approach from a safety/efficiency perspective is imperative. This review provides the recent progress on the AFB1 detoxification from oily matrices by focusing on the peroxidase-based nanozymes technologies and enzymatic-like mechanisms of reactive species in detail for the first time. Significantly, the superiority of enzymatic-like activity in capturing/detoxifying AFB1 from oily matrices, change in nutritional quality, organoleptic profiles, and physicochemical properties of oils, and mechanism of action are highlighted by a comparison with various edible oil remediation systems ( i.e., physicochemical, physical, chemical, and biological). The peroxidase nanozyme–based technologies could be of primary importance in the remediation of AFB1 from oily matrices due to the unique merits of nanozymes ( e.g., low-cost, size/surface-dependent properties, excellent efficiency and durability/stability, recoverability, biocompatibility, many capabilities to maintain the nutritional quality, and without require to any pre-treatment). Finally, this review aimed to provide several beneficial insights regarding safety, universality, finance, ecology, rapidity, selectivity, detoxification path, and toxicity/biological nature of transformed products in peroxidase-mimicking nanozyme technologies. • Nanomaterials with enzyme-like activity for AFB1 decontamination in oily matrices. • Evaluation of AFB1 degradation mechanisms and product toxicity in various systems. • Impact of AFB1 removal technologies on the nutritional value of oily samples. • Comparative analysis of AFB1 removal systems regarding efficiency and feasibility. • The knowledge gaps and cardinal challenges for peroxidase-like nanozyme technologies. Aflatoxin ; Toxicity ; Peroxidase ; Chemistry ; Biochemical engineering ; Environmental chemistry ; Nanotechnology ; Materials science ; Biochemistry ; Food science ; Engineering ; Organic chemistry ; Enzyme Advanced Nanomaterials in Catalysis ; Melamine detection and toxicity ; Selenium in Biological Systems
Authors: Giovanni N. Roviello
Source: Pathogens (review, 2025-11-12)
Field: Chemistry — Organic Chemistry

Nature-Inspired Pathogen and Cancer Protein Covalent Inhibitors: From Plants and Other Natural Sources to Drug Development Nature has long served as a prolific source of bioactive compounds, offering structurally diverse scaffolds for the development of therapeutics. In recent years, increasing attention has been given to nature-inspired covalent inhibitors, molecules that form covalent bonds with pathogen- or cancer-specific targets, due to their potential selectivity and sustained biological activity. This review explores the landscape of covalent inhibitors derived from natural sources, with a focus on compounds from fungi, marine organisms, bacteria and plants. In particular, emphasis is placed on the molecular mechanisms through which these compounds exert their activity against different types of pathogens and other biomedically relevant targets, highlighting key structural motifs that facilitate covalent interactions. Furthermore, the review discusses recent advances in synthetic modification, target identification, and optimization strategies that bridge natural compound discovery with modern drug development. By drawing insights from nature's chemical repertoire, this work ultimately displays the potential of natural covalent inhibitors as a promising foundation for next-generation anti-infective and anticancer therapeutics. Covalent bond ; Drug discovery ; Drug development ; Small molecule ; Chemical biology ; Covalent binding ; Pathogen ; Natural (archaeology) Click Chemistry and Applications ; Microbial Natural Products and Biosynthesis ; Biochemical and Structural Characterization
Authors: Marisol Gastelum-Cabrera | Pablo Méndez-Pfeiffer | Manuel G. Ballesteros‐Monrreal | Brenda Velasco | Patricia Dolores Martinez-Flores | Sergio Silva-Bea | Vicente Domínguez-Arca | Gerardo Prieto | Sílvia Barbosa | Ana Otero | Pablo Taboada | Josué Juárez
Source: Pharmaceutics (article, 2025-05-20)
Field: Materials Science — Materials Chemistry

Phytosynthesis and Characterization of Silver Nanoparticles from Antigonon leptopus: Assessment of Antibacterial and Cytotoxic Properties <b>Background:</b> Silver nanoparticles (AgNPs) show promises as antimicrobial biomaterials with use for combating multidrug-resistant microorganisms, and they are widely used in healthcare, medicine, and food industries. However, traditional physicochemical synthesis methods often require harsh conditions and toxic reagents, generating harmful waste. The synthesis of AgNPs using plant-derived bioactive compounds offers an eco-friendly alternative to conventional methods. <b>Methods:</b> In this study, a bio-green approach was employed to synthesize AgNPs using ethanolic extracts from <i>Antigonon leptopus</i> leaves (EXT-<i>AL</i>). The synthesis was optimized under different pH conditions (5.5, 8.0, 10.0) and EXT-<i>AL</i> concentrations (10-200 μg/mL). Antibacterial activity was evaluated against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, and cytotoxicity was assessed in HeLa, CaCo-2, T731-GFP, and HaCaT cell lines. <b>Results:</b> UV-Vis spectroscopy confirmed nanoparticle formation, with a surface plasmon resonance peak at 410 nm. Alkaline conditions (pH 10.0) favored the formation of smaller, spherical AgNPs. Characterization by DLS, TEM, and AFM revealed uniform nanoparticles with a hydrodynamic diameter of 93.48 ± 1.88 nm and a zeta potential of -37.80 ± 1.28 mV. The AgNPs remained stable in Milli-Q water but tended to aggregate in PBS, DMEM, and MHB media. Antibacterial assays demonstrated significant bactericidal activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> at 3.9 μg/mL (Ag⁺ equivalent). Cytotoxicity tests showed no toxicity to HeLa, T731-GFP, CaCo-2, or HaCaT cells at concentrations ≥ 7.8 μg/mL after 24 h. <b>Conclusions:</b> These findings highlight <i>Antigonon leptopus</i> extract as a sustainable and cost-effective resource for AgNPs synthesis, with strong antimicrobial properties and potential biomedical applications. HaCaT ; HeLa ; Cytotoxicity ; Zeta potential ; Chemistry ; Nuclear chemistry ; Escherichia coli ; Silver nanoparticle ; Surface plasmon resonance ; Antibacterial activity ; Biocompatibility ; Staphylococcus aureus ; Nanoparticle ; Antimicrobial ; Bioreporter ; Nanotechnology ; Biochemistry ; Bacteria ; Materials science ; Organic chemistry ; In vitro ; Biology ; Reporter gene Nanoparticles: synthesis and applications ; Essential Oils and Antimicrobial Activity ; Medicinal Plants and Neuroprotection
Authors: Marcel Hoffmann | Fritz E. Kühn
Source: Chemical Society Reviews (review, 2025-01-01)
Field: Chemistry — Organic Chemistry

Au NHC complexes as anticancer agents: milestones, strategies and future developments The need for selective and efficient anticancer therapies drives the development of gold N-heterocyclic carbene (NHC) as efficient metallodrugs. Their stability, tunable electronics, and versatile steric features make NHCs ideal ligands, which, paired with an antiproliferating gold centre, form an exemplary metal complex for anticancer research. This review highlights the progress made in designing gold NHC complexes, emphasizing strategies to enhance cytotoxicity and selectivity towards cancer cells while minimizing toxicity to healthy tissues, emphasizing the crucial role of the NHC ligand. Furthermore, challenges concerning revealing the precise modes of action are discussed. Mechanistic pathways beyond the inhibition of thioredoxin reductase are highlighted. By underlining recent developments, this review aims to pave the way to a rational design of next-generation gold NHC complexes. Thioredoxin reductase ; Rational design ; Cytotoxicity ; Carbene ; Steric effects ; Gold Compounds N-Heterocyclic Carbenes in Organic and Inorganic Chemistry ; MXene and MAX Phase Materials ; Catalytic Cross-Coupling Reactions
Authors: Ru-Yan Li | Meng-Juan Tang | Yun‐Lan Li | Fan Yang | Hua-Hong Zou | Hai‐Ling Wang | Zhong‐Hong Zhu
Source: Chemical Science (article, 2025-12-26)
Field: Materials Science — Materials Chemistry

Improving the conjugation of organic ligands enhances the antenna effect and promotes the luminescence and optical imaging of chiral mononuclear Eu( <scp>iii</scp> ) complexes Regulating the conjugated structure of organic ligands to enhance the molar absorption coefficient can effectively promote the energy transfer process of the antenna effect and is one of the most effective ways to construct lanthanide complex emitters with bright luminescence. Herein, 2-pyridinecarboxaldehyde was condensed with (1<i>R</i>,2<i>R</i>/1<i>S</i>,2<i>S</i>)-1,2-diphenylethylenediamine under <i>in situ</i> conditions to form ((1<i>E</i>,1'<i>E</i>)-<i>N</i>,<i>N</i>'-(1,2-diphenylethane-1,2-diyl)bis(1-(pyridin-2-yl)methanimine)) (L2), which was further coordinated with Eu(iii) ions to obtain a pair of dynamic chiral mononuclear Eu(iii) complex isomers (<i>R</i>/<i>S</i>-Eu) with aggregation-enhanced antenna effect behavior. Remarkably, in the single-molecule state, <i>R</i>/<i>S</i>-Eu exhibit no significant emission, while in the aggregated state, they both exhibit bright red luminescence. Density functional theory (DFT) calculations demonstrate that the energy levels of the ligand L2 closely match those of <i>R</i>-Eu, ensuring efficient ligand-metal energy transfer. The mononuclear Eu(iii) complex isomers <i>R</i>/<i>S</i>-Eu exhibited obvious circularly polarized luminescence (CPL) performance, with luminescence asymmetry factors (<i>g</i> <sub>lum</sub>) of 0.072/0.068, 0.159/0.073, and 0.045/0.002 at 511, 523, and 535 nm, respectively. Furthermore, <i>R</i>/<i>S</i>-Eu-DMSO demonstrated high-resolution optical imaging of various living cells and was specifically localized to lysosomal organelles. The chiral complex <i>R</i>-Eu-DMSO was primarily taken up by the zebrafish yolk sac and liver, exhibiting bright red luminescence and excellent optical imaging performance. This work not only provides a new method for improving the photophysical properties of chiral lanthanide complex isomers, but also opens up new horizons for expanding the bio-optical imaging applications of chiral lanthanide complex isomers. Luminescence ; Lanthanide ; Antenna effect ; Ligand (biochemistry) ; Absorption (acoustics) ; Antenna (radio) ; Chirality (physics) ; Ion Lanthanide and Transition Metal Complexes ; Luminescence Properties of Advanced Materials ; Radioactive element chemistry and processing
Authors: Zhan‐Dong Mei | Yutong Zhang | S. W. Sun | Yaowu He | Hong Meng
Source: Chemical Engineering Journal (article, 2025-11-30)
Field: Materials Science — Polymers and Plastics

Triarylamine-based electrochromic materials: From design to multifunctional devices Electrochromism ; Electrochromic devices ; Interface (matter) ; Scalability ; Design elements and principles ; Supercapacitor Conducting polymers and applications ; Covalent Organic Framework Applications ; Transition Metal Oxide Nanomaterials
Authors: Xiaoliang Zhang | Sijia Wu | Ran Liu | Hui Jiang | Shubo Jing | Hong Zhuang
Source: International Journal of Biological Macromolecules (review, 2025-06-05)
Field: Materials Science — Biomaterials

Smart-responsive chitosan-based materials for precise degradation control and environmental remediation: A review Environmental remediation ; Chitosan ; Degradation (telecommunications) ; Biochemical engineering ; Environmental degradation ; Environmental science ; Nanotechnology ; Chemistry ; Materials science ; Computer science ; Chemical engineering ; Engineering ; Contamination ; Ecology ; Telecommunications Nanocomposite Films for Food Packaging ; Conducting polymers and applications ; Polydiacetylene-based materials and applications
Authors: Barbora Šalovská | Wenxue Li | Oliver M. Bernhardt | Pierre‐Luc Germain | qiongjiao wang | Tejas Gandhi | Lukas Reiter | Yansheng Liu
Source: Nature Communications (article, 2025-05-30)
Field: Chemistry — Spectroscopy

A robust multiplex-DIA workflow profiles protein turnover regulations associated with cisplatin resistance and aneuploidy Quantifying protein turnover is fundamental to understanding cellular processes and advancing drug discovery. Multiplex-DIA mass spectrometry (MS), combined with dynamic SILAC labeling (pulse-SILAC, or pSILAC) reliably measures protein turnover and degradation kinetics. Previous multiplex-DIA-MS workflows have employed various strategies including leveraging the highest isotopic labeling channels to enhance the detection of isotopic signal pairs. Here we present a robust workflow that integrates a machine learning algorithm and channel-specific statistical filtering, enabling dynamic adaptation to channel ratio changes across multiplexed experiments and enhancing both coverage and accuracy of protein turnover profiling. We also introduce KdeggeR, a data analysis tool optimized for pSILAC-DIA experiments, which determines and visualizes peptide and protein degradation profiles. Our workflow is broadly applicable, as demonstrated on 2-channel and 3-channel DIA datasets and across two MS platforms. Applying this framework to an aneuploid cancer cell model before and after cisplatin resistance, we uncover strong proteome buffering of key protein complex subunits encoded by the aneuploid genome mediated by protein degradation. We identify resistance-associated turnover signatures, including mitochondrial metabolic adaptation via accelerated degradation of respiratory complexes I and IV. Our approach provides a powerful platform for high-throughput, quantitative analysis of proteome dynamics and stability in health and disease. Multiplex ; Aneuploidy ; Workflow ; Cisplatin ; Computational biology ; Biology ; Bioinformatics ; Genetics ; Computer science ; Gene ; Chemotherapy ; Database Advanced Proteomics Techniques and Applications ; Mass Spectrometry Techniques and Applications ; Metabolomics and Mass Spectrometry Studies
Authors: Hatice Mutlu | Bercis Pektas | C. Remzi Becer | Azra Kocaarslan
Source: Macromolecular Rapid Communications (review, 2025-08-06)
Field: Chemistry — Organic Chemistry

Green and Sustainable Chemistry Approaches on Azide‐Based Click Reactions in Polymer Science Click Chemistry, particularly the azide-alkyne cycloaddition (AAC) reaction, has revolutionized polymer chemistry, enabling precise and efficient synthesis of advanced functional materials. With its high regioselectivity, mild reaction conditions, and versatility, AAC reactions align closely with the principles of Green and Sustainable Chemistry. However, the core principles of Click Chemistry, particularly its compatibility with Green Chemistry ideals-such as reduced waste, high atom economy, and mild reaction conditions-remain insufficiently emphasized in the context of polymer chemistry. The review evaluates current limitations in AAC-particularly the challenges associated with hazardous azide reagents and reliance on non-renewable resources-and explores innovative solutions, including greener catalysts, solvent-free systems, and the incorporation of renewable feedstocks. Additionally, the review presents a comparison of activation methods, spanning thermal, catalytic, metal-free, and strain-promoted pathways, to highlight their respective advantages and trade-offs in sustainability. Practical applications of AAC in polymer design are discussed, showcasing its role in creating materials with tailored properties such as thermal stability, bioactivity, and electronic functionality. This analysis provides a roadmap for future research to optimize AAC for sustainability without compromising its effectiveness in materials design. Click chemistry ; Atom economy ; Green chemistry ; Azide ; Cycloaddition ; Chemistry ; Nanotechnology ; Catalysis ; Regioselectivity ; Combinatorial chemistry ; Biochemical engineering ; Organic chemistry ; Materials science ; Reaction mechanism ; Engineering Click Chemistry and Applications ; Advanced Biosensing Techniques and Applications ; Chemical Synthesis and Analysis