jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Ehsan Kianfar
Source: Trends in Sciences (article, 2025-06-30)
Field: Materials Science — Polymers and Plastics

Dendrimers in Medicine: Properties, Drug Encapsulation Mechanisms and Applications Dendrimers are nano-sized, radially symmetric molecules with well-defined, homogeneous, and monodisperse structure that has a typically symmetric core, an inner shell, and an outer shell. Each group of dendrimers is very similar in terms of size, shape, length of branches, surface functional groups, and surface properties. Dendrimers can trap different molecules among their branches according to their size, surface properties (such as electrical charge), and functional groups, and prevent them from being affected by external factors. They can also release the molecules inside them according to environmental conditions. Dendrimers can be used to transport hydrophobic molecules in a hydrophilic environment and vice versa. These varied characteristics make dendrimers a good choice in the medical field, and this review covers their diverse applications. HIGHLIGHTS Investigating Features of dendrimers. Investigating Types of dendrimers. Investigating Dendrimer Drugs. GRAPHICAL ABSTRACT Encapsulation (networking) ; Drug ; Dendrimer ; Nanotechnology ; Computer science ; Materials science ; Chemistry ; Pharmacology ; Medicine ; Computer security ; Organic chemistry Dendrimers and Hyperbranched Polymers ; Computational Drug Discovery Methods ; Synthesis and Characterization of Heterocyclic Compounds
Authors: Sijongesonke Peter | Eric Morifi | Mutshinyalo Nwamadi | Samson O. Oselusi | Asongwe Tantoh | Thierry Y. Fonkui | Derek Tantoh Ndinteh | Blessing A. Aderibigbe
Source: Pharmaceutics (article, 2025-05-30)
Field: Chemistry — Organic Chemistry

Ferrocene-Based Hybrid Drugs as Potential Anticancer and Antibacterial Therapeutic Agents for Incorporation into Nanocarriers: In Silico, In Vitro, Molecular Docking Evaluations <b>Background/Objectives:</b> Cancer and bacterial cases are increasing. Hence, new drugs to treat these diseases are paramount. Ferrocene-based hybrid compounds were synthesizedas potential cancer and bacteria therapeutics. <b>Methods:</b> The synthesized compounds were characterized via FTIR, NMR, and LC-MS and evaluated against different cancer cells and bacterial strains. Moreover, computational studies of these compounds were conducted using several silico tools. <b>Results:</b> Among the synthesized compounds, hybrid <b>10</b> was the most promising compound, displaying promising anticancer activity with IC<sub>50</sub> values between 42.42 and 45.37 and 50.64 and 73.37 µg/mL against HeLa and CHO cancer cells, respectively, with a selective index greater than one on HeLa cancer cells. Compounds <b>22</b>-<b>26</b> displayed promising antibacterial activity with a MIC value of 7.8125 µg/mL against most bacterial strains in vitro. The in silico results revealed that this compound has strong binding affinities for 4qtb, 3eqm, and 2w3l cervical cancer proteins, exhibiting binding energies of -7.3, -8.7, and 7.4 kcal/mol, respectively. Furthermore, hybrid <b>10</b> showed promising pharmacokinetics and drug-like properties, including high GI absorption, moderate water solubility, favoring the oral administration route, nontoxicity, and is a P-gp substrate. <b>Conclusions:</b> The findings obtained in this study illustrate that hybrid compounds are potential therapeutics that need to be explored. The compounds also contained functionalities relevant for incorporating into nanocarriers to improve their biological activities further. Therefore, further studies are recommended for the most effective compounds to reinforce these findings. Nanocarriers ; In silico ; In vitro ; Pharmacology ; Chemistry ; Docking (animal) ; Combinatorial chemistry ; Computational biology ; Drug ; Biology ; Biochemistry ; Medicine Ferrocene Chemistry and Applications ; Synthesis and Biological Evaluation ; Chemical Synthesis and Analysis
Authors: Dhony Hermanto | Nurul Ismillayli | Rahadi Wirawan
Source: Trends in Sciences (article, 2025-11-30)
Field: Materials Science — Materials Chemistry

Approach Towards Sustainable Synthesis of Silver Nanoparticles by Electrolysis Method Using Asian Pennywort Extract and Their Anti-Inflammatory Activity Biogenic metal nanoparticles continue gaining popularity due to their low production costs, biocompatibility, and several environmental and biological benefits. In this work, Asian pennywort extract (APE) will be electrolysed to produce biogenic silver nanoparticles (AgNPs) sustainably. This study also aims to improve APE’s in vitro anti-inflammatory properties. The extract solution acts as an electrolyte in the system, facilitating the formation of AgNPs via electrochemical synthesis, as shown by the appearance of a peak at 430 nm. In accordance with the FTIR spectra, the phytochemical screening findings of the extract showed a preponderance of phenols, flavonoids, and triterpenes. It suggests that the biomolecules in the extract serve as both stabilising and reducing agents, playing a role in the synthesis process. TEM micrographs demonstrate that AgNPs have a uniform spherical shape and are surrounded by a thin biomolecular layer with diameters of 32.62 ± 10.53 nm. The light scattering pattern of colloidal AgNPs also exhibits a particle size distribution of 32.50 ± 5.68 nm. The approach generates polycrystalline nanoparticles ranging in size from 17.55 to 32.26 nm. AgNPs outperformed APE in terms of anti-inflammatory action, with IC50 values of 523.40 ± 7.85 and 960.29 ± 16.81 µg/mL, as determined by the BSA protein denaturation procedure. The electrosynthesis approach using APE biomolecules suggests a novel strategy for producing AgNPs with superior anti-inflammatory capabilities, leading to promising future applications for large-scale production in the pharmaceutical and cosmetics industries. HIGHLIGHTS The facile, inexpensive, fast, sustainable, and environmentally friendly synthesis of silver nanoparticles. Asian pennywort extract as an electrolyte, bioreductor, and stabilising agent in electrosynthesis. The produced AgNPs are polycrystals with a spherical shape of approximately 32.62 nm with high purity. The produced AgNPs have strong anti-inflammatory activity. GRAPHICAL ABSTRACT Silver nanoparticle ; Biomolecule ; Nanoparticle ; Electrosynthesis ; Dynamic light scattering ; Electrolysis ; Fourier transform infrared spectroscopy ; Particle size Nanoparticles: synthesis and applications ; Moringa oleifera research and applications ; Phytochemicals and Medicinal Plants
Authors: Chenglong Yin | Jin Huang | Shenghua Deng | Chong Ma | Yong Peng
Source: Frontiers in Chemistry (article, 2025-09-04)
Field: Materials Science — Biomaterials

Sodium carbonate and sodium silicate promote the Ca-montmorillonite: the nucleation, stabilization and hydrophilicity mechanisms Montmorillonite is widely utilized in catalysis, environmental science, and civil engineering. Previous studies have demonstrated that Na<sub>2</sub>CO<sub>3</sub> and Na<sub>2</sub>SiO<sub>3</sub> enhance the stability of Ca-montmorillonite-rich clayey soils in chemical soil stabilization. However, the microscopic mechanisms underlying their effects on nucleation, stabilization, and hydrophilicity remain unclear. This study investigates these mechanisms using Scanning Electron Microscopy (SEM) and Density Functional Theory (DFT) calculations. SEM results show that Na<sub>2</sub>CO<sub>3</sub> and Na<sub>2</sub>SiO<sub>3</sub> enhance the strength of the stabilized soils by promoting the formation of cementitious and crystalline substances. DFT calculations reveal that SiO<sub>3</sub> <sup>2-</sup> and CO<sub>3</sub> <sup>2-</sup> exhibit the most negative adsorption energies of -6.2 eV and -5.1 eV, respectively, in the exchangeable layers of montmorillonite, significantly higher than those of Na<sup>+</sup> and Ca<sup>2+</sup>. On the montmorillonite surface, SiO<sub>3</sub> <sup>2-</sup> and CO<sub>3</sub> <sup>2-</sup> display even lower adsorption energies of -8.7 eV and -6.8 eV, respectively. Water molecules preferentially adsorb dissociatively on the montmorillonite surface with an energy of -3.1 eV; however, their adsorption is suppressed following the adsorption of Ca<sup>2+</sup>, Na<sup>+</sup>, CO<sub>3</sub> <sup>2-</sup>, and SiO<sub>3</sub> <sup>2-</sup>, with energies decreasing to between -1.1 eV and -2.5 eV. Differential charge density plots indicate that ion adsorption leads to charge redistribution and the formation of chemical bonds. Specifically, Ca<sup>2+</sup> and Na<sup>+</sup> donate cationic charge, while CO<sub>3</sub> <sup>2-</sup> and SiO<sub>3</sub> <sup>2-</sup> accept electrons. The study further explains why Na<sub>2</sub>CO<sub>3</sub> and Na<sub>2</sub>SiO<sub>3</sub>, in combination with lime, are more effective than lime alone in soil stabilization. A mechanism model for nucleation, stabilization, and hydrophilicity is proposed to explain the role of Na<sub>2</sub>CO<sub>3</sub> and Na<sub>2</sub>SiO<sub>3</sub> in promoting Ca-montmorillonite stabilization. This work provides valuable insights into the chemical properties of montmorillonite and the synergistic effects of calcium-based stabilizers combined with Na<sub>2</sub>CO<sub>3</sub> and Na<sub>2</sub>SiO<sub>3</sub> for soil stabilization. Montmorillonite ; Silicate ; Nucleation ; Sodium ; Sodium carbonate ; Sodium silicate ; Chemistry ; Carbonate ; Chemical engineering ; Inorganic chemistry ; Organic chemistry Clay minerals and soil interactions ; Calcium Carbonate Crystallization and Inhibition ; Concrete and Cement Materials Research
Authors: Brianna Burnsworth | Sneed KB | Yashwant Pathak
Source: Chemical & Pharmaceutical Research (article, 2025-03-31)
Field: Materials Science — Biomaterials

Recent Trends in Nano Drug Delivery Systems for Cancer Treatment Nanotechnology has revolutionized cancer therapy by enabling precise drug delivery systems that enhance therapeutic efficacy while minimizing side effects. This review explores recent advancements in nano-drug delivery systems targeting breast, prostate, and brain cancers. It delves into various nanocarrier platforms, including liposomal, polymeric, and magnetic systems, highlighting their design, functionality, and clinical applications. The discussion encompasses the challenges associated with these nanocarriers, such as biocompatibility, targeted delivery, and overcoming biological barriers. By examining current research and clinical trials, this paper provides a comprehensive overview of the transformative potential of nanotechnology in cancer treatment. Future perspectives on personalized nanomedicine and multifunctional nanoparticles are also presented. Nanomedicine ; Nanocarriers ; Drug delivery ; Cancer therapy ; Cancer treatment ; Targeted drug delivery ; Cancer ; Transformative learning Nanoparticle-Based Drug Delivery ; Cancer Research and Treatment ; Nanoplatforms for cancer theranostics
Authors: Man Lu | Yi Liu | Jin Zhu | Jiarong Shang | Lu Bai | Zhichao Jin | Wenting Li | Yue Hu | Xia Zheng | Jun Qian
Source: Frontiers in Oncology (review, 2025-01-08)
Field: Materials Science — Materials Chemistry

Mapping the intellectual structure and emerging trends on nanomaterials in colorectal cancer: a bibliometric analysis from 2003 to 2024 This study offers an in-depth analysis of the application of nanomaterials in CRC, promoting interdisciplinary collaboration and advancing scientific progress in this field. Colorectal cancer ; Nanomaterials ; Cancer research ; Medicine ; Cancer ; Nanotechnology ; Oncology ; Internal medicine ; Materials science Nanoparticles: synthesis and applications ; Nanoparticle-Based Drug Delivery ; Vitamin D Research Studies
Authors: Weijie Li | Guangxin Yao | Ruibin Mo | Weiwei Liu | Xiang Jiang | Xinya Zhang
Source: Journal of Applied Polymer Science (article, 2025-04-05)
Field: Materials Science — Polymers and Plastics

Bioinspired Robust Mechanical and Waterproofing Properties of Moisture‐Curing Polyurethane With Multiple Hydrogen Bonding Networks ABSTRACT Moisture‐curing polyurethane (MCPU) is widely used in waterproofing applications due to its excellent adaptability and ease of construction. However, traditional MCPU suffers from poor mechanical properties, primarily due to low curing efficiency and limited molecular chain extension. Inspired by the layered structure of spider silk, a mechanical MCPU is developed by incorporating adipic dihydrazide (ADH) as a chain extender to construct multiple hydrogen bonding networks within the MCPU matrix. These networks facilitate molecular chain extension and promote the formation of a controllable microphase separation structure, significantly enhancing the mechanical properties of MCPU. The resulting MCPU exhibits remarkable mechanical properties, achieving a tensile strength of 8.64 MPa and an elongation of 2448.32%, which are 2.14 times and 7.00 times higher than the ASTM D6947/D6947‐16 standards (4.14 MPa and 350%), respectively. Furthermore, the MCPU coatings demonstrate exceptional waterproofing capabilities, withstanding 1 m of static water pressure for 1 month and enduring −0.1 MPa dynamic pressure for 2 h. Therefore, this work presents a novel and effective strategy for enhancing the mechanical and waterproofing properties of low‐molecular‐weight MCPUs, offering significant potential for advanced industrial applications. Waterproofing ; Curing (chemistry) ; Polyurethane ; Materials science ; Composite material ; Hydrogen bond ; Moisture ; Isocyanate ; Polymer science ; Chemistry ; Organic chemistry ; Molecule Polymer composites and self-healing ; Photopolymerization techniques and applications ; Marine Sponges and Natural Products
Authors: Xueyu Jiang | Fanwei Zeng | Yan Li | Yang Yi | Xiaodong Tang | Ang Lu
Source: Aggregate (article, 2025-02-12)
Field: Materials Science — Materials Chemistry

Ultrafine‐Mn‐Loaded N,O‐Doped Nanocarbon via Mott‒Schottky Effect for Photo‐Enhanced Antibacterial Therapy and Wound Healing ABSTRACT Bacterial infections are one of the greatest threats to wound healing, and microbial resistance has increased the demand for new antimicrobial dressings. Artificial nanozymes possess myriad considerable advantages, including low cost and high activity, for targeted biological treatments. Despite significant efforts made in nanozyme engineering, significant challenge remains that their catalytic performance is far from satisfactory in wound treatment. Herein, based on biowaste valorisation, we propose a sustainable and efficient strategy to synthesize an ultrafine‐Mn‐loaded (3.0 ± 1 nm) N,O‐doped porous nanocarbons (Mn‐PNCs) nanozyme via the Mott−Schottky effect. The nanozyme achieves mid‐temperature (45.8°C) and superior photothermal conversion efficiency (77.62%), photothermally enhanced peroxidase‐like activity that contributes to the effective treatment of methicillin‐resistant Staphylococcus aureus ‐infected wounds. The photo‐enzyme platform further reduced the inflammatory response, normalized epidermal tissue regeneration, and accelerated wound healing. Notably, the mechanism demonstrated that this Mott−Schottky catalyst can trigger the rapid transfer of electrons to release reactive oxygen species (ROS) species, as a heterojunction system is strongly capable of changing the electron density within the metal. Under photothermal induction, the Mott–Schottky contact can be used to fabricate other polysaccharide‐derived nanozymes in tissue engineering, or on the high‐value application of biomass resources. Photothermal therapy ; Wound healing ; Materials science ; Nanotechnology ; Regeneration (biology) ; Reactive oxygen species ; Schottky barrier ; Chemistry ; Cell biology ; Optoelectronics ; Immunology ; Medicine ; Biochemistry ; Biology Advanced Nanomaterials in Catalysis ; Nanoplatforms for cancer theranostics ; Graphene and Nanomaterials Applications
Authors: Michaela Falkenroth | Marcel Dann
Source: Frontiers in Photobiology (article, 2025-07-21)
Field: Materials Science — Biomaterials

Engineering light-driven biomineralization for a sustainable carbonate economy Photosynthetic activity of cyanobacteria is a prominent driver of cell-surface catalysed extracellular calcium carbonate (CaCO 3 ) precipitation. This natural process termed “biomineralization” occurs only under specific circumstances but has given rise to significant carbonate rock formation throughout geological time. Engineering cyanobacterial cell surfaces for enhanced and constitutive biomineralization of abundant ocean-water dissolved Ca 2+ and flue-gas CO 2 into CaCO 3 may allow for the biotechnological re-capture of CO 2 released by industrial processes such as thermal decarboxylation of CaCO 3 . This may both limit net greenhouse gas emissions and transform CaCO 3 into a sustainable resource. Drawing from geological precedent and basic biological research, this perspective outlines promising synthetic biology strategies to convert cyanobacterial biomineralization into a cornerstone technology for a sustainable carbonate economy. Biomineralization ; Carbonate ; Chemical engineering ; Geochemistry ; Geology ; Materials science ; Engineering ; Metallurgy Calcium Carbonate Crystallization and Inhibition ; Algal biology and biofuel production ; Paleontology and Stratigraphy of Fossils
Authors: Bojidarka Ivanova
Source: Preprints.org (preprint, 2025-01-23)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Linear and Nonlinear Optical Properties of Non-Centrosymmetric Crystals of Substituted Aliphatic Secondary Amines This paper like contributions to leading developments of nonlinear optical materials research aims for interdisciplinary readership and recognizing experimental and theoretical crystallographic, linear and nonlinear optical properties of non-centrosymmetric crystals of substituted aliphatic secondary amines as prospective templates for technological application. It deals with crystal structure of (2-piperazin-1-yl-ethyl)-nitrimine dihydrate (1) reported first, herein, that can be solved into both the P-1 and P1 space groups and 3,3,5-trimethyl-5-((nitroamino)methyl)cyclohexanaminium hydroxide (2) that could be solved into Pc and Pca21 ones. Crystals of (1) and (2) exhibit optical transparency within 190–1100 nm. Comparative analysis with data on novel crystal structure of (2-piperazin-1-yl-ethyl)-carbamic acid dihydrate (3) is also carried out. There is utilizes high resolution single crystal X-ray diffraction, high accuracy quantum chemical methods for in-depth understanding of relation among molecular and crystal structures, crystallographic packing, symmetry, linear optical and nonlinear optical properties. There are also used electronic and Fourier transform infrared vibration spectroscopy. Organic material research might provide evolutionary development in the face of innovative change of photonics technologies. The research effort, so far, has shown that they are mainly rigid crystals. However, future photonics technologies mandate organic flexible devices; thus, opening research avenue for implementation of organic photonics and electronics devices. Materials science ; Photonics ; Crystal (programming language) ; Nonlinear optics ; Crystallography ; Nanotechnology ; Optoelectronics ; Chemistry ; Nonlinear system ; Physics ; Computer science ; Quantum mechanics Nonlinear Optical Materials Research ; Synthesis and biological activity ; Structural and Chemical Analysis of Organic and Inorganic Compounds
Authors: Yufeng Sun | Ziqiang Xu | Yijing Liu | Jintao Zhu
Source: Nano Research (article, 2025-06-30)
Field: Materials Science — Materials Chemistry

Gold nanocluster assemblies: Assembly strategies and biomedical applications Gold nanoclusters (AuNCs) have garnered significant attention due to their unique photoluminescent, catalytic, and therapeutic properties. Since the discovery of their ability to enhance emission through aggregation, researchers have extensively studied hybrid nanomaterials formed by combining AuNCs with various components through assembly. Assembly can significantly improve the original performance of AuNCs and confer additional properties such as responsiveness and targeting. These assembly strategies greatly expand the potential applications of AuNCs and are regarded as essential means to improve the detection, imaging, and therapeutic capabilities. This review categorizes recent advancements in AuNC assembly methods, including self-assembly and co-assembly of AuNCs. In addition, the emerging directions in the <em>in vivo </em>assembly and disassembly of AuNCs are also being addressed. We also discuss the applications of AuNC assemblies in <em>in vitro</em> biodetection, <em>in vivo</em> bioimaging, and therapeutic platforms. Finally, we offer prospects for the future development of AuNC assemblies. With further exploration of assembly strategies, mechanisms, and application designs, AuNC assemblies are expected to play a more significant role in more fields. Nanotechnology ; Materials science ; Nanoclusters Nanocluster Synthesis and Applications ; Gold and Silver Nanoparticles Synthesis and Applications ; Advanced Nanomaterials in Catalysis
Authors: Patricia López‐Gómez | Nabila Mehwish | Vicente Marchán | Maria‐Pau Ginebra | Carlos Mas‐Moruno
Source: Chemistry - A European Journal (article, 2025-06-16)
Field: Materials Science — Biomaterials

Tailoring Self‐Assembled Peptide Hydrogels with Antimicrobial or Cell Adhesive Properties for Tissue Engineering Bacterial colonization on biomaterials is a major issue, leading to approximately 20% of implant failures due to infection and biofilm formation. To address this, peptide-based hydrogels incorporating tailored bioactive peptides have emerged as promising candidates for applications in tissue engineering and infection control. Here, we have designed peptide sequences that incorporate i) a self-assembling unit (SaU) and ii) bioactive motifs, including the well-known arginine-glycine-aspartate (RGD) sequence to promote cell adhesion or an antimicrobial peptide derived from lactoferrin (LF) to exhibit antibacterial properties. To aid in the gelation, these peptides were combined with hyaluronic acid (HA), rendering peptide-based hydrogels without the need for additional external assembly triggers, simplifying their application in biomedical contexts. This protocol allowed for a spontaneous formation of a 3D fibrillar network, with structural and physicochemical properties suitable for tissue engineering. The biological evaluation revealed the ability of RGD-based hydrogels to increase the adhesion and spreading of osteoblastic cells compared to controls, while the LF-based hydrogels significantly reduced the viability and attachment of both Gram-positive and Gram-negative strains, clearly affecting bacterial morphology. This report demonstrates the feasibility of this technology to produce hydrogels incorporating distinct biological cues, highlighting their potential as versatile biomaterials to address diverse biomedical challenges. Self-healing hydrogels ; Adhesive ; Tissue engineering ; Peptide ; Antimicrobial ; Materials science ; Self adhesive ; Self-assembling peptide ; Antimicrobial peptides ; Nanotechnology ; Biomedical engineering ; Chemistry ; Polymer chemistry ; Engineering ; Biochemistry ; Organic chemistry Supramolecular Self-Assembly in Materials ; Antimicrobial Peptides and Activities ; Polydiacetylene-based materials and applications