jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Donald R. Baer | Peter M. A. Sherwood
Source: Frontiers in Analytical Science (article, 2025-01-22)
Field: Materials Science — Surfaces, Coatings and Films

Perspective on the development of XPS and the pioneers who made it possible As of 2024, the use of X-photoelectron spectroscopy (XPS), initially called Electron Spectroscopy for Chemical Analysis (ESCA), has grown to become the most widely used surface analysis method. In this paper we offer a perspective of the early development of XPS and describe some of the advances and pioneers who made them that provided the foundation for it to grow into the technique we know today. Included is information about the early development of photoelectron spectroscopy, the seminal work of Kai Siegbahn, influential conferences that helped spread excitement and provide a fundamental understanding of the method, early development of commercial instruments, and identification of the need for systematic metrology. Because hundreds of researchers have contributed to advancing the method, we note that this is our perspective, with likely a different emphasis than others may have chosen. To limit the scope somewhat, we have chosen to focus on authors whose contributions started before 1980. Perspective (graphical) ; Development (topology) ; Computer science ; Mathematics ; Artificial intelligence Electron and X-Ray Spectroscopy Techniques ; Advancements in Photolithography Techniques ; Advanced Electron Microscopy Techniques and Applications
Authors: Aminul Islam | Pranab Ghosh
Source: RSC Advances (review, 2025-01-01)
Field: Chemistry — Organic Chemistry

Frontiers in bond construction: innovative approaches to C–C and carbon–heteroatom (C–S, C–N, C–O, C–Se, C–P) transformations-a review This comprehensive review explores the cutting-edge innovations driving modern bond construction, with a specific focus on C-C and carbon-heteroatom (C-S, C-N, C-O, C-Se, C-P) transformations. It critically examines how groundbreaking catalytic strategies including transition-metal catalysis, solid-face, photolytic protocols, and organocatalytic systems are revolutionizing synthetic methodologies by enabling unprecedented levels of selectivity, functional group tolerance, and operational simplicity under mild reaction conditions. The review dissects of these transformations, highlighting how advanced reaction protocol has paved the way for the rational design of next-generation catalytic methodology that overcomes classical synthetic limitations. Emphasis is placed on sustainable and environmentally benign approaches that integrate with green chemistry principles, thus broadening the applicability of these methods in the synthesis of complex molecules for pharmaceuticals, materials science, and other interdisciplinary applications. Future perspectives, challenges, and emerging trends are also discussed, offering valuable insights into the ongoing evolution of bond construction strategies and setting the stage for continued innovation in organic synthesis. Heteroatom ; Carbon fibers ; Chemistry ; Bond ; Materials science ; Organic chemistry ; Business ; Ring (chemistry) Sulfur-Based Synthesis Techniques ; Catalytic C–H Functionalization Methods ; Radical Photochemical Reactions
Authors: Xin Meng
Source: Journal of Cancer Biomoleculars and Therapeutics (review, 2025-01-01)
Field: Materials Science — Biomaterials

Therapeutic Efficacy of Platinum Based Medicines Combined with Various Nanoparticles in the Treatment of Colorectal Cancer: A Comprehensive Review Colorectal cancer continues to be a major cancer that affects patients in terms of morbidity and mortality. Chemotherapy using cisplatin, oxaliplatin among others based with platinum have remained the mainstay in the treatment of diverse cancer including the colorectal cancer. However, these treatments are not very effective because of drug resistance, systemic toxicity, and low selectivity. The advances in nanotechnology in the past years presented nanoparticles as potential drug delivery systems which provide sharp targeting, minimum toxicity and better therapeutic efficacy. This review aims at discussing how platinum-based drugs can complement nanoparticles, for example liposomes, dendrimers and gold nanoparticles for colorectal cancer treatment. This review, discussed how nanoparticles can improve the effectiveness of platinum drugs; present sample findings from preclinical and clinical research; and analyze the perspectives of such combinations for the current therapy shortcomings overcoming. Furthermore, authors have looked at the prospects and challenges of this relatively young branch of research and discuss the opportunities that can lie in personalized medicine concepts, as well as the further evolution of nanoparticles. The purpose of this review is to enhance the current knowledge of platinum-nanoparticle combinations and to outline its future directions for colorectal cancer treatment. Oxaliplatin ; Colorectal cancer ; Medicine ; Cancer ; Drug delivery ; Cisplatin ; Nanomedicine ; Drug ; Oncology ; Nanotechnology ; Pharmacology ; Chemotherapy ; Internal medicine ; Nanoparticle ; Materials science Nanoparticle-Based Drug Delivery ; Nanoparticles: synthesis and applications ; Nanomaterials for catalytic reactions
Authors: N Ramyashree | Lokesh Kumar S | Sumaiya Tabassum | Sony J. Chundattu | Santhosh Govindaraju
Source: ChemistrySelect (article, 2025-02-01)
Field: Chemistry — Organic Chemistry

Efficient Single‐Pot Synthesis of Thiazole Derivatives: A Synoptic View Abstract In recent years, heterocyclic compounds have gained significant interest due to their tremendous application in the medicinal, optical, and biological fields. Among them, thiazole is an important heterocycle containing nitrogen‐ and sulfur‐ in the ring, which stands out as the best for its pharmacological activity. One of the best routes to synthesize these molecules is through multicomponent reactions. Being a sustainable methodology, it gives insights into generating an extensive range of biologically active molecules. This review focuses on the significance of three‐component and four‐component syntheses of thiazole under various conditions from the year 2000 to late 2024, which are particularly important due to their ability to produce thiazole derivatives with good yields. Thiazole ; Combinatorial chemistry ; Chemistry ; Computer science ; Stereochemistry Synthesis and biological activity ; Multicomponent Synthesis of Heterocycles ; Quinazolinone synthesis and applications
Authors: S. Muthukrishnan | S. Bhakya | Vaikundamoorthy Ramalingam
Source: Discover Applied Sciences (article, 2025-09-29)
Field: Materials Science — Materials Chemistry

Metal nanoparticles synthesis: an overview of different synthesis methods, mode of action and their biomedical application The development of reliable and eco-friendly methods for synthesizing metal nanoparticles is a pivotal step in advancing the field of nanotechnology. This comprehensive review discusses various synthesis routes and the applications of biosynthesized nanoparticles. The biosynthesis of metallic nanoparticles is the subject of a number of recent reviews, which focus on the various synthesis methods and characterization of the final products. The key applications reviewed here include biomedical applications, especially antimicrobial, antifungal, antiviral applications, also cytotoxicity effects, special embassies with molecular mechanism of silver nanoparticles in anticancer activity. It compares efficient synthesis methods via green routes to physical and chemical methods, which provide strong evidence for the selecting suitable method for the synthesis of silver nanoparticles. These findings will helpful for future investigations concerning the use of silver nanoparticles as different biomedical application in the areas of medical and food industry. Nanoparticle ; Characterization (materials science) ; Chemical synthesis ; Silver nanoparticle ; Metal Nanoparticles: synthesis and applications ; Graphene and Nanomaterials Applications ; Laser-Ablation Synthesis of Nanoparticles
Authors: Shogo Hamada | Hironori Sugiyama | Yiting Zhang | Shoji Iwabuchi | Soichiro Hiroi | Toshiki Maruyama | Yashwanth Balaji | Shinji Kumagai | Satoshi Murata | Taro Toyota
Source: ChemSystemsChem (article, 2025-01-13)
Field: Chemistry — Organic Chemistry

Micrometer‐Sized Liposome‐Based Systems: A Hierarchical Breakdown Abstract Liposomes have attracted attention as a compartment for various synthetic biomolecular systems, including artificial cells and drug delivery carriers. Notably, micrometer‐sized liposomes (MSLs) have emerged as a key platform for engineering de novo biomolecular systems, extending beyond their role as model compartments in scientific research. However, there is still a lack of reviews on MSLs from the perspective of artificial systems across various disciplines from basic sciences to applied sciences and to engineering. In this review, we aim to fill this gap by providing a hierarchical breakdown that offers a systematic overview of MSL design and experimental methods. Primarily targeted at readers new to the field, our review presents a unified description of MSL‐based functional systems and guidance on experimental details such as lipid composition and preparation methods. Our approach seeks to present a consolidated perspective of functionalized liposomes as an artificial system, contributing to advancements across various disciplines. Micrometer ; Liposome ; Nanotechnology ; Materials science ; Engineering ; Mechanical engineering Polydiacetylene-based materials and applications ; Advanced biosensing and bioanalysis techniques ; Lipid Membrane Structure and Behavior
Authors: Shao‐Zhe Yi | Bao-Ning Li | Wen He | Mei Pan
Source: Materials Chemistry Frontiers (article, 2025-01-01)
Field: Chemistry — Physical and Theoretical Chemistry

Conformational regulation to realize modifiable ESIPT (excited-state intramolecular proton transfer) through intermolecular interactions Conformational regulation to realize modifiable ESIPT emissions was achieved by tuning the intermolecular interactions of a dual-ESIPT site molecule with different crystallizers. Intermolecular force ; Intramolecular force ; Excited state ; Proton ; Photochemistry ; State (computer science) ; Materials science ; Aggregation-induced emission ; Chemical physics ; Chemistry ; Molecule ; Atomic physics ; Organic chemistry ; Computer science ; Fluorescence ; Physics Photochemistry and Electron Transfer Studies ; Radical Photochemical Reactions ; Chemical Reactions and Mechanisms
Authors: Xiangyu Zhang | Rufan Chen | Yongxiang Zhou | Zekun Chen | Guo Qin Xu | Qing‐Hua Xu
Source: EES solar. (article, 2025-01-01)
Field: Materials Science — Materials Chemistry

Recent progress in covalent organic frameworks as heterogeneous photocatalysts for photochemical conversion Recent progress of covalent organic frameworks as heterogeneous photocatalysts has been reviewed, covering design strategies and their applications in photocatalytic H 2 evolution, CO 2 reduction, organic transformation, and H 2 O 2 production. Covalent bond ; Photochemistry ; Covalent organic framework ; Metal-organic framework ; Photocatalysis ; Chemistry ; Nanotechnology ; Materials science ; Catalysis ; Organic chemistry ; Adsorption Covalent Organic Framework Applications ; Chemical Synthesis and Reactions ; Advanced Photocatalysis Techniques
Authors: Maheswar Maji | Mrinal Kanti Mandal | Rajib Ghosh Chaudhuri
Source: Advanced Sustainable Systems (article, 2025-05-22)
Field: Materials Science — Materials Chemistry

Covalent Organic Frameworks: A State‐of‐the‐Art from Design, Synthesis to Gas Sensing Application with the Prospect of Ammonia Gas Detection Abstract The rapid growth of human society and the necessity of protecting human health and security underscore the importance of identifying the toxic gases emitted by industrial sectors. Ammonia (NH 3 ) is a widely produced industrial colorless toxic gas with a strong odor, coupled with its harmful environmental and health impacts, such as contributing to air pollution (PM 2.5 formation) and severe impact on the respiratory system of the human body, even at low concentrations. Covalent Organic Frameworks (COFs) have emerged as revolutionary materials to address these current issues. The crystalline porous network through the dynamic covalent chemistry of COFs possesses versatile structural and chemical properties that make them ideal for gas sensing. This review provides a comprehensive overview of the latest advancements in COF‐based gas sensors with a focus on ammonia sensing. Moreover, the detailed discussion about the structural design and synthesis methods of COFs and their important characterization techniques is presented. It concludes by providing a future outlook for developing advanced COF materials in gas sensing applications. Ammonia ; Covalent bond ; Nanotechnology ; Chemistry ; Ammonia gas ; State (computer science) ; Environmental science ; Process engineering ; Materials science ; Computer science ; Organic chemistry ; Engineering Covalent Organic Framework Applications ; Metal-Organic Frameworks: Synthesis and Applications ; Advanced Photocatalysis Techniques
Authors: Tomas V. Frankovich | Harrison M. McCann | Kyle Hoffman | Anthony F. Rullo
Source: ACS Central Science (article, 2025-09-08)
Field: Chemistry — Organic Chemistry

Covalent Ligand Electrophiles Are Differentially Activated by Proximity Effects Which Govern Latent Protein Reactivity Covalent ligands contain an electrophilic moiety that reacts with a nucleophilic residue on a target protein, following an initial reversible binding event. Covalent ligand development typically involves efforts to increase on-target selectivity by maximizing the ligand binding affinity and minimizing intrinsic electrophile reactivity. Problematically, this limits labeling kinetics and requires high affinity ligands. The concept of "latency" describes the potential for "turn-on" activation of electrophiles upon target engagement. Here, we investigate the potential intrinsic latency of covalent electrophiles and test the hypothesis that diverse electrophiles can be differentially activated by proximity effects. We develop a kinetic effective molarity (EM <sub><i>k</i></sub> ) approach to quantitatively characterize kinetics associated with diverse electrophilic reaction mechanisms, both with and without binding proximity effects. We observe that different electrophiles are associated with significantly different EM <sub><i>k</i></sub> parameters, with SuFEx and acrylamide electrophiles associated with the highest intrinsic latency. Eyring transition state analysis revealed that all covalent ligands, independent of electrophile, benefit from significant transition state entropic stabilization. Strikingly, electrophiles associated with the highest latency are associated with greater relative transition state stabilization with different enthalpic and entropic contributions. These findings quantitatively describe electrophile latency and will aid the mechanism-guided development of next-generation covalent ligands associated with "turn-on" reactivity. Electrophile ; Covalent bond ; Moiety ; Ligand (biochemistry) ; Nucleophile ; Residue (chemistry) Click Chemistry and Applications ; Cyclopropane Reaction Mechanisms ; Chemical Synthesis and Analysis
Authors: Galyna Maleeva | Carlo Matera | Silvia Roda | Alessio Colleoni | Marco De Amici | Pau Gorostiza
Source: Medicinal Research Reviews (review, 2025-04-10)
Field: Materials Science — Materials Chemistry

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward-motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions. Despite years of sustained research, it is not fully established how dopaminergic neurotransmission governs these important functions through a relatively small number of neurons that release dopamine. Light-driven neurotechnologies, based on the use of small light-regulated molecules or overexpression of light-regulated proteins in neurons, have greatly contributed to the advancement of our understanding of dopaminergic circuits and our ability to control them selectively. Here, we overview the current state-of-the-art of light-driven control of dopaminergic neurotransmission. While we provide a concise guideline for the readers interested in pharmacological, pharmacogenetic, and optogenetic approaches to modulate dopaminergic neurotransmission, our primary focus is on the usage of photocaged and photo-switchable small dopaminergic molecules. We argue that photopharmacology, photoswitchable molecules of varied modalities, can be employed in a wide range of experimental paradigms, providing unprecedent insights into the principles of dopaminergic control, and represent the most promising light-based therapeutic approach for spatiotemporally precise correction of dopamine-related neural functions and pathologies. Dopaminergic ; Neuroscience ; Optogenetics ; Neurotransmission ; Dopamine ; Dopaminergic pathways ; Psychology ; Biology ; Medicine ; Receptor ; Internal medicine Photochromic and Fluorescence Chemistry ; Photoreceptor and optogenetics research ; Receptor Mechanisms and Signaling
Authors: Yao Feng | Weiqi Gao | Limeng Li | Yijun Huang | Wei Sang | Ruiping Zhang
Source: Advanced Healthcare Materials (review, 2025-05-23)
Field: Materials Science — Biomaterials

Nanomedical Strategies for Kidney Disease: Diagnostic Innovations and Therapeutic Advancements Kidney diseases, posing significant global public health challenges due to their complex pathogenesis and diagnostic/therapeutic difficulties, have seen emerging advancements through nanomedicine. In diagnostics, nanoparticles leverage unique physicochemical properties to enhance imaging precision. Superparamagnetic iron oxide nanoparticles improve magnetic resonance imaging sensitivity by amplifying T<sub>2</sub>-weighted contrast, while microbubbles/nanobubbles enhance ultrasound resolution via signal reflection. Quantum dots and gold nanoparticles optimize photoacoustic imaging with superior fluorescence and photostability. Therapeutically, nanoparticle-based drug delivery systems demonstrate targeted delivery, reduced systemic toxicity, and improved drug stability and bioavailability in preclinical studies. Nanocarrier-integrated stem cell and gene therapies further show potential in repairing renal cells and mitigating kidney injury. This review systematically examines nanomedicine's dual diagnostic and therapeutic roles in kidney diseases, compares strengths and limitations of various nanodelivery platforms, and addresses current challenges in clinical translation. By exploring novel nanotechnology-driven strategies, it aims to guide future research toward effective, tailored therapies for improved renal disease management. Disease ; Medicine ; Intensive care medicine ; Kidney disease ; Pathology ; Internal medicine Nanoparticle-Based Drug Delivery ; Nanoplatforms for cancer theranostics ; Advanced Nanomaterials in Catalysis
Authors: Alessandra Forni | Daniele Malpicci | Elena Lucenti | Luca Zecchinello | Alessia Colombo | Elena Cariati
Source: Chemical Science (review, 2025-01-01)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Recent advances in mono- and multi-nuclear photoluminescent Cu( <scp>i</scp> ) complexes with nitrogen containing ligands and their stimuli responsiveness Luminescent Cu(i)-derivatives represent a highly desirable alternative to their noble metal analogues in view of copper's relative abundance and low environmental concerns while maintaining large color tunability, high quantum yield and low photo-thermal lability. Moreover, the large variety of structural forms, spanning from 0D mononuclear to 3D polynuclear compounds characterized by peculiar emissive features, opens the door to an incredibly huge family of Cu(i) derivatives with potential application in many different fields. The present review focuses on luminescent neutral 0D mono-, di-, tri- and tetranuclear Cu(i) complexes with N-donor ligands developed during the period 2020 to mid-2025. After a general overview, specific sections are dedicated to members of each nuclearity. Emphasis is given to compounds' stimuli responsiveness, in particular towards vapour exposure and thermal and mechanical perturbations. Luminescence ; Photoluminescence ; Yield (engineering) ; Quantum yield ; Nitrogen ; Metal Magnetism in coordination complexes ; Metal complexes synthesis and properties ; Nanocluster Synthesis and Applications
Authors: Lei Tang | Jiaoyun Wang | Yuan Liu
Source: Molecules (article, 2025-02-14)
Field: Chemistry — Spectroscopy

Triazine-Modified Color-Responsive Triarylboron/Acridine Fluorescent Probe with Multi-Channel Charge Transfer for Highly Sensitive Fluoride Ion Detection A novel fluoride ion fluorescent probe is designed by introducing the strong electron-withdrawing triazine groups into the triarylboron/acridine conjugation system. The A-D-A' molecular configuration endows this molecule with multiple charge-transfer channels; upon reaction with F<sup>-</sup>, the triazine groups act as primary acceptors within the molecule, facilitating charge transfer between the acridine units and the triazine groups. During fluoride ion detection, changes in the triarylboron moiety lead to a significant bathochromic-shift in fluorescence emission from green to yellow. Theoretical calculations attribute this phenomenon to a reduction in the molecular <i>S</i><sub>1</sub> state energy level upon fluorination, resulting in a pronounced visible color change and chromogenic response during detection. Based on fluorescence intensity changes with varying degrees of F<sup>-</sup> coordination, a detection limit as low as 10<sup>-7</sup> M was determined for TB-1DMAc-2TRZ, demonstrating the high sensitivity of this probe. Fluorescence ; Triazine ; Fluoride ; Acridine ; Ion ; Chemistry ; Photochemistry ; Charge (physics) ; Materials science ; Optoelectronics ; Optics ; Inorganic chemistry ; Polymer chemistry ; Organic chemistry Molecular Sensors and Ion Detection ; Luminescence and Fluorescent Materials ; Carbon and Quantum Dots Applications