jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Hesham N. Mustafa | Saima Daud | Sabahat Sheraz | Maria Bibi | Tauseef Ahmad | Asma Sardar | Tanzeela Fazal | Asma Khan | Obaid‐ur‐Rahman Abid
Source: Archiv der Pharmazie (review, 2025-05-01)
Field: Chemistry — Organic Chemistry

The Chemistry and Bioactivity of Mefenamic Acid Derivatives: A Review of Recent Advances Mefenamic acid (MA) represents an efficient nonsteroidal anti-inflammatory drug (NSAID) for treatment in many circumstances of painful conditions and inflammation, but its poor water solubility and gastrointestinal side effects often obstruct its clinical application. Consequently, researchers have been conducting studies on the synthesis of prodrugs and heterocyclic compounds as MA derivatives for the improvement of their pharmacological profile. This review discusses an overview of recent developments in the synthesis and biological applications of MA derivatives. It covers several strategies used to modify the chemical structure of MA to pursue pharmacokinetic improvement, solubility, and targeting features, among which are heterocyclic moieties and prodrug design. Following the many synthetically produced derivatives of MA, mainly proposed between classic organic synthesis and more recent methodologies, such as microwave-assisted synthesis and green chemistry protocols, this review will consider how different structural variations are able to influence the assumed pharmacological actions: analgesic, anti-inflammatory, and anticancer. The findings demonstrate significant progress toward the development of safer and more effective NSAID therapies; thus, they support, in a broad and unprecedented way, the potential of MA derivatives and prodrugs in transforming the state of pain management and inflammation treatment. Mefenamic acid ; Prodrug ; Nonsteroidal ; Chemistry ; Pharmacology ; Combinatorial chemistry ; Drug ; Solubility ; Analgesic ; Chemical synthesis ; Medicine ; Organic chemistry ; Biochemistry ; In vitro Synthesis and biological activity ; Synthesis and Biological Evaluation ; Phenothiazines and Benzothiazines Synthesis and Activities
Authors: Moritz Maxeiner | Ruben Maile | Murat Cuvalli | Andreas Wolf | Ayisha Komal | Robert Oestreich | Christoph Janiak | Karl Mandel | Alexander Knebel | Klaus Müller‐Buschbaum
Source: Advanced Functional Materials (article, 2025-04-02)
Field: Materials Science — Materials Chemistry

NanoMOF‐Based Multilevel Anti‐Counterfeiting by a Combination of Visible and Invisible Photoluminescence and Conductivity Abstract This study presents nanosized metal‐organic framwork (nanoMOF)‐based multifunctional mixed‐matrix‐membranes (MMMs) and composite powders as extremely sensitive responder materials for a responder‐stimulus based multilevel anti‐counterfeiting. The physicochemical properties of nanoMOF‐based composites offer a wide operational range as anti‐counterfeiting tags. Nine responder materials are presented, constituted of trivalent lanthanide‐containing nanoMOFs ([Ln 3 (bdc) 4.5 (H 2 O) 3 (dmf) 2 ] (nLn‐bdc); bdc 2− ═benzene‐1,4‐dicarboxylate; Ln═Eu, Tb, Yb) and polystyrene sulfonate, pyrolyzed resorcinol‐formaldehyde and polysulfone as matrices. These materials inherit distinct properties, and their combination provides visible and near‐infrared light emission and specific conductivity for multiple security level anti‐counterfeiting. The additive and interdependent nature of security features in the developed anti‐counterfeiting materials ensures that altering one feature will invariably affect others, thereby reinforcing the overall integrity and resilience of the security mechanism. Even the pitch‐black composites of nLn‐bdc and pyrolyzed resorcinol‐formaldehyde show bright light emission to the near‐infrared range, when stimulated by UV‐light being suitable for black materials. This work also describes a matrix‐based active contribution as security feature to an anti‐counterfeiting tag, instead of being solely used as a carrier for the security feature‐bearing nanoMOFs. The combination of multiple levels of security by different properties marks these multifunctional composites as anti‐counterfeiting materials being complicated to copy including a proof‐of‐principle experiment. Materials science ; Photoluminescence ; Conductivity ; Nanotechnology ; Optoelectronics ; Physical chemistry Luminescence and Fluorescent Materials ; ZnO doping and properties ; Nanocluster Synthesis and Applications
Authors: Aynura Karimova | Sabina Hajizada | Habiba Shirinova | Sevinj Nuriyeva | Lаla Gahramanli | Aygun Mehdiyeva | Goncha Eyvazova | Toghrul Sadikhov | Natalia Lenz | Inji Nasirova | Christoph Reißfelder | Vugar Yagublu
Source: Frontiers in Nanotechnology (article, 2025-09-22)
Field: Materials Science — Biomaterials

Dextran-coated Fe3O4 nanoparticles with ratio-dependent drug loading: structural characterization and cytotoxicity in colorectal cancer cells Introduction This study focuses on the development of dextran-coated iron oxide nanoparticles (Fe 3 O 4 @Dextran NPs) as carriers for chrysin, a natural flavonoid with recognized anticancer activity. Methods Fe 3 O 4 @Dextran NPs were synthesized via co-precipitation and loaded with chrysin at different drug-to-nanoparticle ratios. Structural and physicochemical characterization was performed using X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and Vibrating Sample Magnetometry (VSM). Drug loading efficiency was determined spectrophotometrically. The anticancer efficacy of the drug-loaded samples was assessed in vitro against HCT-116 human colorectal carcinoma cells using the MTT assay, with statistical analysis performed by one-way ANOVA. Results XRD revealed an average crystallite size of 17 nm for Fe 3 O 4 @Dextran, which decreased to ∼15 nm upon chrysin loading. FTIR confirmed the successful incorporation of chrysin without compromising structural stability. VSM measurements demonstrated superparamagnetic behavior with a saturation magnetization of 69.2 emu/g. Drug loading efficiencies were 42%, 54%, and 57% at drug-to-nanoparticle ratios of 1:0.5, 1:1, and 1:2, respectively, with evidence of saturation at higher concentrations. The Fe 3 O 4 @Dextran+D2 formulation exhibited optimal drug loading, maintaining structural integrity and enhanced cytotoxic activity against HCT-116 cells. Conclusion Fe 3 O 4 @Dextran+D2 demonstrated favorable structural integrity (as evidenced by XRD and FTIR analyses) along with notable anticancer activity against HCT-116 cells. Its performance is attributed to optimal drug loading without surface saturation, supporting its potential as a structurally stable drug delivery system. Chrysin ; Fourier transform infrared spectroscopy ; Superparamagnetism ; Cytotoxicity ; Drug ; Nanoparticle ; Drug delivery ; Ferrihydrite Nanoparticle-Based Drug Delivery ; Graphene and Nanomaterials Applications ; Nanoparticles: synthesis and applications
Authors: Hyeon Woo Jeong | Kyoung Tae Park | Su Min Oh | Sang Eun Shim | Yingjie Qian
Source: Polymers (article, 2025-02-03)
Field: Materials Science — Polymers and Plastics

Sustainable Reinforcement of Silicone Rubber: Comparative Analysis of Biosilica from Rice Husk and Conventional Silica The objective of this study is to compare rice husk-derived silica (biosilica) synthesized via an environmentally friendly method with conventional silica (Zeosil 175) for reinforcing the mechanical properties of silicone rubber. The silanol group content of Zeosil 175 (9.45 OH/nm<sup>2</sup>) is higher than that of biosilica (7.07 OH/nm<sup>2</sup>), whereas the specific surface area of biosilica (159.52 m<sup>2</sup>/g) exceeds that of Zeosil 175 (144.90 m<sup>2</sup>/g). Silicone rubber specimens containing two types of silica nanoparticles were prepared at loading levels of 5, 10, 15, 20, 25, and 30 parts per hundred rubber to evaluate their mechanical properties and characteristics. Results indicate that silicone rubber filled with biosilica shows comparable tensile strength to Zeosil 175 at low filler contents, which can be attributed to its higher specific surface area. However, at higher loading levels, the mechanical properties are somewhat diminished due to the Payne effect and filler agglomeration resulting from the larger particle size of biosilica. These experimental findings offer insights into the potential utilization of rice husk-derived biosilica as an alternative to conventional silica in enhancing the properties of silicone rubber alongside the findings of the mechanical analysis. Husk ; Silanol ; Ultimate tensile strength ; Silicone rubber ; Materials science ; Natural rubber ; Filler (materials) ; Composite material ; Silicone ; Tear resistance ; Precipitated silica ; Particle size ; Chemical engineering ; Chemistry ; Organic chemistry ; Catalysis Polymer Nanocomposites and Properties ; Structural Behavior of Reinforced Concrete ; Silicone and Siloxane Chemistry
Authors: Divya Yadav | Sumistha Das | Divya Dhillayan | Sashi Yadav | Santosh Bhukal
Source: Discover Agriculture (article, 2025-05-11)
Field: Materials Science — Materials Chemistry

Environmentally benign nanotechnology: transforming elements into nano-agrochemicals for sustainable farming The twenty-first century is widely regarded as the era of nanotechnology, offering cutting-edge solutions across diverse applications, including medicine, cosmetics, electronics, and sustainable environment development. Amidst a growing global population and limited food resources, meeting the ever-increasing demand for food has become a significant challenge. While addressing this demand, the widespread use of agrochemicals has led to heightened residual toxicity, posing serious long-term threats to human health. To counter these issues, numerous eco-friendly strategies have been explored globally. Among these, the application of nanotechnology in smart agriculture and precision farming has emerged as a promising approach. Nanomaterials, with their unique size-dependent properties, have enabled advancements in targeted fertilizer and pesticide delivery, the detection of agrochemical hazards, crop protection, antimicrobial and antifungal applications, and the preservation of soil microbiomes. These innovations offer safer and more sustainable agricultural practices. Green approaches utilizing biological resources have garnered significant attention in synthesizing nanomaterials due to their eco-friendly and biosafe nature, even after prolonged use. This review highlights the novelty of green-synthesized nanomaterials, such as zinc and copper nanoparticles, emphasizing their multifaceted potential in promoting sustainable agriculture and environmental conservation. By focusing on green synthesis routes and their agricultural applications, the article provides valuable insights into a cutting-edge approach that bridges the gap between advanced nanotechnology and sustainable farming practices. This review presents a novel perspective on the role of green-synthesized nanoparticles (NPs) in sustainable agriculture, highlighting their potential as innovative nano-agrochemicals. Agrochemical ; Agriculture ; Nanotechnology ; Nano- ; Applications of nanotechnology ; Engineering ; Materials science ; Biology ; Ecology ; Chemical engineering Nanoparticles: synthesis and applications ; Nanotechnology research and applications
Authors: Hongliang Li | Zilu Zhang | Hanjie Guo | Chao Ren | C. Liu | Li Xiang
Source: Heritage (article, 2025-08-20)
Field: Materials Science — Materials Chemistry

Recent Progress on Corrosion Behavior, Mechanism, and Protection Strategies of Bronze Artefacts With their rich historical, artistic, and scientific value, bronze artefacts form a significant part of our cultural heritage. These items, often found in museums around the world, offer a glimpse into past civilizations and their technological advancements. However, due to their prolonged burial and subsequent exposure to varying environmental conditions, these artefacts are prone to corrosion, necessitating meticulous preservation efforts. This review discusses the cultural significance and preservation challenges of bronze artefacts, which are emblematic of human civilization’s progression. This text highlights the historical and artistic value of ancient bronze artefacts, especially those from China, underscoring their intricate casting techniques and aesthetic richness. Despite their cultural importance, these bronze artefacts confront severe preservation issues, particularly the pervasive threat of corrosion, commonly referred to as “bronze disease”. This text also reviews the complex interplay between alloy composition, microstructure, and environmental factors that influence corrosion mechanisms. It requires an enhanced understanding of these factors to develop effective preservation strategies. This paper also emphasizes the need for innovative, eco-friendly technologies to prevent further degradation while maintaining the integrity of these precious artefacts. The applications of corrosion inhibitions, organic/inorganic coatings, as well as the newly developed strategies like the photo-induced passivation technique, 3D scanning and 3D printing techniques, and holographic projection/real and virtual technique for the direct or indirect protection and cultural transmission of the bronze artefacts were also introduced. This review concludes by underscoring the urgency of these research and development efforts to safeguard our cultural heritage for future generations. Bronze ; Corrosion ; Mechanism (biology) ; Materials science ; Metallurgy ; Philosophy ; Epistemology Corrosion Behavior and Inhibition ; Recycling and Waste Management Techniques ; Metallurgy and Material Science
Authors: Gayathri R. Ediriweera | Yi-Xin Chang | Wenting Yang | Andrew K. Whittaker | Changkui Fu
Source: Molecules (article, 2025-02-13)
Field: Chemistry — Organic Chemistry

Self-Assembled Protein–Polymer Nanoparticles via Photoinitiated Polymerization-Induced Self-Assembly for Targeted and Enhanced Drug Delivery in Cancer Therapy Protein-polymer bioconjugates offer numerous advantages in biomedical applications by integrating the benefits of functional proteins and tunable synthetic polymers. Developing drug-loaded protein-polymer nanoparticles, with a receptor-targeting protein forming the nanoparticle shell, would be ideal for the targeted delivery of drugs to cancer cells that overexpress specific receptors for more effective cancer therapy. In this study, we report the synthesis of reduction-responsive protein-polymer nanoparticles by a photoinitiated polymerization-induced self-assembly (photo-PISA) approach. Anti-cancer drugs can be efficiently encapsulated at high concentrations within the nanoparticles during the photo-PISA process. These protein-polymer nanoparticles present transferrin (Tf) on their surfaces, capable of targeting the overexpressed Tf receptors found on cancer cells. It was found that the nanoparticles demonstrate enhanced cellular uptake and delivery of the anti-cancer drug, curcumin, to cancer cells via Tf receptor-mediated endocytosis, compared to the control PEGylated nanoparticles that lack targeting capability. Moreover, the nanoparticles can release the encapsulated curcumin in response to a reducing environment, a characteristic of cancer cells compared to health cells. Consequently, the synthesized protein-polymer nanoparticles are more effective in inducing cancer cell death compared to the control nanoparticles, demonstrating their potential as an effective and targeted drug delivery system for cancer therapy. Drug delivery ; Targeted drug delivery ; Cancer therapy ; Nanoparticle ; Polymerization ; Nanotechnology ; Polymer ; Self-assembly ; Drug ; Targeted therapy ; Materials science ; Cancer ; Chemistry ; Medicine ; Pharmacology ; Organic chemistry Advanced Polymer Synthesis and Characterization ; Innovative Microfluidic and Catalytic Techniques Innovation ; Nanoplatforms for cancer theranostics
Authors: Andrei Novitskii | Takao Mori
Source: Materials Today Physics (article, 2025-08-30)
Field: Materials Science — Materials Chemistry

Revisiting Pisarenko’s formula: Effective mass estimation, thermopower–conductivity relation, and maximum power factor prediction The thermopower α (also known as the Seebeck coefficient) is one of the most fundamental material characteristics for understanding charge carrier transport in thermoelectric materials. Here, we revisit the Pisarenko formula for the thermopower, which was traditionally considered valid only for non-degenerate semiconductors. We demonstrate that regardless of the dominating scattering mechanism, the Pisarenko formula describes accurately enough the relationship between thermopower α and charge carrier concentration n beyond the non-degenerate limit. Moreover, the Pisarenko formula provides a simple thermopower-conductivity relation, α = ± k B e ( b − ln σ ) , where b is a constant determined by the scattering mechanism and weighted mobility μ w , and σ is the electrical conductivity. This relation is valid for materials with α > 90 µ V K − 1 when acoustic phonon scattering is predominant. This offers an alternative way to analyze electron transport when Hall measurements are difficult or inaccessible. Additionally, we show how the Pisarenko formula can be used to estimate the maximum power factor of a thermoelectric material from the weighted mobility of a single, not necessarily optimized, sample at any given temperature. • Pisarenko formula demonstrated to be applicable beyond the non-degenerate semiconductor limit. • Thermopower value of 150 µV K -1 is identified as threshold for accurate effective mass estimation. • α -ln σ plot proposed as a tool for carrier transport analysis. • Analytical prediction of maximum power factor from weighted mobility is demonstrated. Materials science ; Conductivity ; Seebeck coefficient ; Power (physics) ; Relation (database) ; Estimation ; Thermodynamics ; Statistical physics ; Statistics ; Applied mathematics ; Mathematics ; Thermal conductivity ; Quantum mechanics ; Composite material ; Physics ; Data mining ; Computer science Advanced Thermoelectric Materials and Devices ; Advanced Thermodynamics and Statistical Mechanics ; Thermal properties of materials
Authors: Esraa A. Elhawary | Raya Soltane | Mohamed H. Sharaf | Amer M. Abdelaziz | Mohamed A. Said | Eman Maher Zahran
Source: Pharmaceuticals (article, 2025-08-25)
Field: Materials Science — Materials Chemistry

Sustainable MnO2/MgO Bimetallic Nanoparticles Capped with Sword Fern Methanol Extract Attain Antioxidant/Anti-Biofilm Potential: A UPLC-ESI/LC/MS and Network Pharmacology-Supported Study <b>Background</b>: <i>Nephrolepis exaltata</i> (sword fern) possesses a considerable amount of phytochemicals and different biological activities. The current study investigates the anti-biofilm potential of greenly synthesized bimetallic nanoparticles of <i>Nephrolepis exaltata</i> leaf methanol extract (NEME-MnO<sub>2</sub>-MgO BNPs). <b>Methods</b>: The NEME was subjected to UPLC/MS analysis, followed by characterization of its NPs by size, zeta potential, FTIR, entrapment efficiency, and release. Then, antioxidant, antimicrobial and antibiofilm assays were employed, followed by in silico studies. <b>Results</b>: The UPLC/MS analysis of NEME led to the tentative identification of 27 metabolites, mostly phenolics. The MnO<sub>2</sub>-MgO BNPs presented a uniform size and distribution and exhibited IC<sub>50</sub> values of 350 and 215.6 μg/mL, in the DPPH and ABTS assays, respectively. Moreover, the NPs exhibited antimicrobial and anti-biofilm efficacies against <i>Pseudomonas aeruginosa</i>, <i>Klebsiella pneumonia</i> (ATCC-9633), <i>Staphylococcus aureus</i> (ATCC-6538), <i>Escherichia coli</i>, <i>Bacillus cereus</i>, and <i>C. albicans</i>, with MIC values of 250-500 μg/mL. The MnO<sub>2</sub>-MgO BNPs inhibited <i>Candida albicans</i> biofilms with a % inhibition of 66.83 ± 2.45% at 1/2 MIC. The network pharmacology highlighted epigallocatechin and hyperoside to be the major compounds responsible for the anti-biofilm potential. The ASKCOS facilitated the prediction of the redox transformations that occurred in the green synthesis, while the docking analysis revealed enhanced binding affinities of the oxidized forms of both compounds towards the outer membrane porin OprD of <i>P. aeruginosa</i>, with binding scores of -4.6547 and -5.7701 kcal/mol., respectively. <b>Conclusions</b>: The greenly synthesized <i>Nephrolepis exaltata</i> bimetallic nanoparticles may provide a promising, eco-friendly, and sustainable source for antimicrobial agents of natural origin with potential biofilm inhibition. Chemistry ; Bimetallic strip ; Fern ; Traditional medicine ; Chromatography ; Pharmacology ; Biochemistry ; Medicine ; Biology ; Botany ; Catalysis Nanoparticles: synthesis and applications ; Phytochemistry and Bioactivity Studies ; Phytochemistry and Biological Activities
Authors: Nazish Saleem Abbas | Muhammad Jamil | Nayab Ariff | Hamid Sharif | Peiguang Yan
Source: Advanced Materials Interfaces (review, 2025-07-01)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Emerging Trends of MXene Nanocomposites in Textile Substrates for Enhanced EMI Shielding: A Systematic Review Abstract Electromagnetic interference (EMI) shielding represents a critical technological challenge demanding innovative materials with superior performance characteristics. This comprehensive review systematically explores MXene nanomaterials as a transformative EMI shielding solution, critically analyzing traditional nanomaterial approaches and evaluating MXene's unique properties. The review comprehensively examines MXene's integration into textile substrates through advanced fabrication methodologies, including vacuum filtration, coating and dipping, spray coating, and spin coating techniques. A rigorous assessment of performance metrics encompasses electromagnetic shielding effectiveness, material thickness, electrical conductivity, mechanical properties, surface functionalization, durability, and application‐specific performance characteristics. This work examines how MXenes (Ti 3 C 2 ), with their exceptional conductivity and ease of textile application, can be coupled with other nanomaterials such as graphite, carbon nanotubes (CNT), polyaniline (PANI), and silver nanowires (AgNWs) to improve EMI shielding effectiveness. A comprehensive list of MXene‐based hybrid nanomaterials offers materials scientists and engineers with an important reference framework for understanding and optimizing EMI shielding solutions. Finally, despite underlining MXene's enormous potential, this paper critically states existing constraints, such as nanomaterial dispersion, environmental stability, and production processes. This in‐depth review not only highlights recent achievements in MXene‐based textile composites but also indicates areas where more research is required to solve existing constraints and limitations. Materials science ; Nanocomposite ; EMI ; Composite material ; Electromagnetic shielding ; Textile ; Electromagnetic interference ; Nanotechnology ; Electronic engineering ; Engineering Electromagnetic wave absorption materials ; MXene and MAX Phase Materials ; Advanced Antenna and Metasurface Technologies