jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Weidong Li | Xiaodong Huang | Xiaowen Han | Jiayi Zhang | Bin Ma | Zhenyu Yin | Yuhan Wang | Lei Gao | Jianming Shi | Hao Chen
Source: Frontiers in Immunology (article, 2025-11-18)
Field: Materials Science — Biomaterials

Sequential HIPEC, Claudin18.2-targeted therapy, and CapeOx chemotherapy leading to resolution of peritoneal metastases and curative resection in gastric cancer: a case report and literature review Gastric cancer, a leading global cause of cancer-related mortality, is frequently diagnosed at advanced stages with peritoneal metastasis, significantly limiting curative options. Current strategies integrate systemic chemotherapy, hyperthermic intraperitoneal chemotherapy (HIPEC), and targeted therapies, yet outcomes remain suboptimal. Claudin18.2, a tight junction protein overexpressed in 27.4-52% of gastric cancers, has emerged as a novel therapeutic target, with recent Phase III trials demonstrating survival benefits for Claudin18.2-targeted monoclonal antibodies in HER2-negative advanced disease. However, the synergy of HIPEC with Claudin18.2-targeted therapies remains unexplored. This study presents a case of Claudin18.2-positive advanced gastric adenocarcinoma with peritoneal metastasis treated with a multimodal regimen: HIPEC, systemic CapeOx chemotherapy, and Claudin18.2-targeted therapy (ASKB589). Following 12 cycles, imaging and tumor markers (CA125, CEA) normalized, enabling curative gastrectomy. At 893 days post-diagnosis, the patient remains disease-free (PFS/DFS: 893/573 days) on adjuvant capecitabine. Treatment-related toxicities (predominantly Grade 1-3 hematologic and gastrointestinal events) were manageable. This case highlights Claudin18.2 as an actionable biomarker and proposes a "local-systemic" synergy model for peritoneal-metastatic gastric cancer. However, the absence of cytoreductive surgery and single-case limitations necessitate validation through randomized trials. Future research should prioritize biomarker-driven HIPEC protocols (e.g., nanoparticle-enhanced Claudin18.2-targeted delivery) and dynamic monitoring of Claudin18.2 expression during therapy. Hyperthermic intraperitoneal chemotherapy ; Limiting ; Chemotherapy ; Gastric adenocarcinoma ; Systemic therapy ; Adjuvant chemotherapy ; Metastasis ; Cytoreductive surgery ; Adjuvant Nanoparticle-Based Drug Delivery ; Intraperitoneal and Appendiceal Malignancies ; Barrier Structure and Function Studies
Authors: Warangkana Nimcharoen | Chuntip Sakulkhaemaruethai | Maneerat Khemkhao
Source: Journal of Renewable Energy and Smart Grid Technology (article, 2025-06-19)
Field: Materials Science — Polymers and Plastics

Bio-Based Composite from Sunflower Stalks for Building Wall Panels Burning sunflower stalks after harvesting could pose a significant environmental risk due to particulate matter 2.5 pollution. The use of low-cost recycled materials in building products is on trend. In this study, two distinct methods, hot oven, and hot compression, were used to form a bio-composite from sunflower stalks and bark, using natural latex as a binder. The physical, mechanical, thermal, and acoustic properties of the bio-composite were determined. The test box was used to evaluate the thermal performance of bio-composites. The bio-composites had a density of 515.67–864.24 kg/m3, similar to flat-pressed particleboards (400–900 kg/m3). The moisture content varied from 6.01 to 14.20%, with only the 1:5 and 1:6 sunflower stalk bio-composite by hot compression having a moisture content higher than 13%. Thickness swelling ranged from 5.63% to 12.03%. All composites had a fire resistance of less than 33 mm/min. As natural latex increases, the water absorption of sunflower stalks decreases while at the same time increasing fire resistance. The thermal conductivity coefficient ranged between 0.117 and 0.161 W/mK. The noise reduction coefficient (NRC) of 1:4 sunflower stalks in a hot oven and 1:6 sunflower bark in a hot compression were 0.233 and 0.241, respectively. The hot-compressed 1:6 sunflower bark bio-composite exhibited a room temperature profile that was similar to that of the MDF board. The hot compression method revealed better results in density, water absorption, flexural strength, and flexural modulus than the hot oven method. Sunflower ; Materials science ; Composite material ; Composite number ; Absorption of water ; Moisture ; Water content ; Swelling ; Bark (sound) ; Compression (physics) ; Pulp and paper industry ; Horticulture Natural Fiber Reinforced Composites ; Innovations in Concrete and Construction Materials
Authors: Paweł Gaciek | Mariusz Gaczek | Paweł Krause
Source: Materials (article, 2025-08-29)
Field: Chemistry — Organic Chemistry

Factors Influencing Adhesive Bonding Efficiency in ETICS Application In this study, physical factors influencing the efficiency of adhesive bonding in External Thermal Insulation Composite Systems (ETICS) using the ribbon-and-dab bonding method were analyzed. Tests were carried out to show the distribution of pressure transmitted through thermal insulation to adhesive mortar and substrate during bonding, and to demonstrate the relationship between pressure, adhesive layer thickness, and bond strength of mortar to concrete substrate. The analysis was also based on in situ observations, laboratory experiments, and numerical modeling, with particular attention paid to contact pressure and adhesive strength depending on cement-based mortar layer thickness. Example pull-off tests (CAST, DAST) performed on dabs showed that increasing thickness from 10 mm to 20 mm caused a decrease in bond strength in the central area by about 86% for tested adhesive mortars and substrate-values dropped from 1.8 MPa to below 0.25 MPa, while edge zones often showed no adhesion. Pressure-mapping tests (PMAST) revealed distinct pressure zones within dabs and perimeter ribbons. The analysis showed that average normalized pressures in adhesive dabs reached about 52% of the maximum value, while the [0.9; 1.0] pressure interval covered about 12% of the contact area. Based on empirical data, a decay function was developed to build a model of radial pressure attenuation. Monte Carlo simulations defined ranges of random model parameters and variability of average pressures in a 10 mm adhesive dab. The model allowed inclusion of a peripheral zero-pressure ring and enabled simulation for a 20 mm layer, confirming that increased thickness led to reduced contact pressure and explained the decrease in bonding performance. Adhesive ; Materials science ; Composite material ; Layer (electronics) Photopolymerization techniques and applications
Authors: Ekaterina I. Karzina | Marina A. Gaidym
Source: Труды Санкт-Петербургского государственного морского технического университета (article, 2025-09-23)
Field: Materials Science — Materials Chemistry

Investigation of Atmospheric Corrosion Inhibitors’ Activity Against Mold Fungi BACKGROUND: There is a need to develop effective methods for protecting marine equipment from biochemical corrosion. In addition, pathogenic fungi produce metabolites and enzymes that destroy metal structures. For successful use, such materials must meet the following key requirements: reliable corrosion protection; availability of raw materials for production; user-friendly processes; compatibility with various preservative bases (oil, fuel, and water); the ability to suppress the development of mold fungi; low toxicity and no pungent odor; the ability to control the concentration in the solution; safe disposal methods of used solutions, and affordable cost. AIM: To evaluate the antifungal efficacy of inhibitory compounds used to protect metal structures. METHODS: The study used contact and volatile corrosion inhibitors common in ship repair practice. The study involves the disk diffusion test, which allows to clearly see the fungistatic effect. RESULTS: Experimental studies have shown that volatile inhibitors surpass contact ones. In the premises, an objective hierarchy of inhibitors has been built based on their applicability, biochemical corrosion efficacy, and toxic load. CONCLUSION: The studies show the need for further improvement of methods for protecting ship equipment from biochemical corrosion with an emphasis on the use of volatile inhibitors as a more effective means of protection. Corrosion ; Mold ; Preservative ; Biocide ; Antifungal ; Raw material ; Corrosion inhibitor Corrosion Behavior and Inhibition
Authors: Robert A. Lodder | James T Isaacs | Philip J Almeter | Aaron N Hunter | Thomas A Lyman | Stephanie P Zapata | Bradley S Henderson | Seth A Larkin | Eleonora Hasani | Uiyeol Yoon | Adler Crumrin | J. G. Smith | Spencer Pergrem | Ashton Plymale | Bailee Ramnes | Joshua D Melson | Jeffrey W Reynolds | Ryan W. Naseman | Thomas L Platt
Source: PubMed (article, 2025-01-01)
Field: Chemistry — Analytical Chemistry

Rapid Quality Assessment of Ceftriaxone Using Near-Infrared Spectroscopy Ceftriaxone for injection, USP is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Ceftriaxone sodium is a white to yellowish crystalline powder which is readily soluble in water, sparingly soluble in methanol and very slightly soluble in ethanol. The color of ceftriaxone sodium solutions ranges from light yellow to amber, depending on the length of storage, concentration and diluent used. Each vial contains ceftriaxone sodium equivalent to 250 mg, 500 mg, 1 gram or 2 grams of ceftriaxone activity. Ceftriaxone sodium contains approximately 83 mg (3.6 mEq) of sodium per gram of ceftriaxone activity. Intra-lot variability was detected in the spectra of 6 vials of ceftriaxone sampled from one lot. One of the vials was more than 8.3 multidimensional SDs away from the center of the cluster of the other 5 vials from the same lot, suggesting that the manufacturing process may not be in a state of control. Interlot variability was detected between two lots of the drug using a subcluster detection test (r<sub>tn</sub>=0.9629, r<sub>ts</sub>=0.9148, p=0.02). Ceftriaxone ; Quality (philosophy) ; Infrared spectroscopy ; Infrared ; Quality assessment ; Materials science ; Medicine ; Chemistry ; Microbiology ; Biology ; Optics ; Physics ; Antibiotics ; Pathology ; External quality assessment ; Organic chemistry Analytical Methods in Pharmaceuticals ; Antibiotics Pharmacokinetics and Efficacy ; Pesticide Residue Analysis and Safety
Authors: Dewa Ngurah Yudhi Prasada | Akbar Azzi
Source: BULETIN FISIKA (article, 2025-07-26)
Field: Materials Science — Materials Chemistry

Calculation of TVL and HVL for Shielding Requirements in Radiotherapy Facilities using Monte Carlo Simulation Shielding is a critical aspect of radiation therapy facility design to ensure the safety of both workers and the public. This study utilizes the Particle and Heavy Ion Transport System (PHITS) version 3.35 Monte Carlo code to evaluate the tenth-value layer (TVL) of four common materials, like water (1 g/cm³), concrete (2.35 g/cm³), steel (7.8 g/cm³), and lead (11.36 g/cm³), under various photon beam energies of Ir-192 and Co-60 and with various linac energy of 6 MV, 10 MV, and 15 MV, that representing sources typically used in brachytherapy and external beam radiotherapy. The point source, isotropic source, and collimated source were utilized in this research. Results show that TVL values increase with higher beam energy and decrease with denser materials, following the known principles of radiation attenuation. However, an anomaly was observed in lead, where TVL values decreased at energies ≥10 MV, possibly due to pair production effects, which warrants further investigation. None of the results precisely matched the reference values from IAEA SRS-47, likely due to differences in beam spectrum and inherent filtration. These findings suggest that Monte Carlo simulation is a feasible method for estimating shielding requirements, but validation through measurement is recommended. Monte Carlo method ; Electromagnetic shielding ; Collimated light ; Beam (structure) ; Radiation ; Linear particle accelerator ; Radiation protection ; Photon ; Isotropy Radiation Shielding Materials Analysis ; Radiation Therapy and Dosimetry ; Advanced Radiotherapy Techniques
Authors: Liping Zhang | GAO Chengyan | SHI Qiufeng | GUO Haijie | Lei Wang | Ping Huang | QIAO Jianwei
Source: Chinese Journal of Luminescence (article, 2025-01-01)
Field: Materials Science — Materials Chemistry

Novel Eu&lt;sup&gt;2+&lt;/sup&gt;-activated Apatite Single-host White-emitting Phosphors Phosphor ; Apatite ; Rare earth ; Characterization (materials science) Luminescence Properties of Advanced Materials ; Crystal Structures and Properties ; Polyoxometalates: Synthesis and Applications
Authors: Jordyn Puccio | Karan Pandher | Ahasan Hameed | Alison Boucher
Source: JAAD Case Reports (article, 2025-03-26)
Field: Chemistry — Organic Chemistry

Acneiform drug eruption from pirfenidone Medicine ; Pirfenidone ; Drug eruption ; Dermatology ; Drug ; Pharmacology ; Internal medicine Synthesis and Reactivity of Heterocycles ; Drug-Induced Ocular Toxicity ; Porphyrin Metabolism and Disorders
Authors: Di Wu | Weizhuan Tang | Jia Wang | Yifan Zhao | Li Duan | Qi Kang
Source: Scientific Reports (article, 2025-11-19)
Field: Materials Science — Materials Chemistry

On Chinese space station: pioneering space experiments unraveling the hydrodynamic instability of annular thermocapillary convection On the Chinese space station, a space scientific experiment, named "The microgravity research on oscillation characteristics and transition issues of annular flow", has completed its research plan for the first stage. The payload, supporting multiple annular fluid models with a heating, rotating or lifting central column, is developed for conducting a series of experiments in the fluid physics rack. This paper presents the space experiment with a fixed inner column and focuses on the volume ratio effect on the critical instability of thermocapillary convection. To observe the transition from steady flow to oscillatory flow, an infrared camera is adopted to record the temperature pattern of the annular flow. The instability critical point, critical frequency and instability mode are analyzed by the dynamic mode decomposition (DMD). The space experiment shows that the volume ratio(Vr) has a significant influence on the mode of thermocapillary instability by the surface configuration. The critical curves are divided into two branches according to critical frequencies, which are low-frequency modes (f = 0.056 ~ 0.072 Hz, Vr = 0.625 ~ 1.065) and high-frequency modes (f = 0.301 ~ 0.419 Hz, Vr = 0.525 ~ 0.575), respectively. The low-frequency modes include various azimuthal wave modes, i.e. regular wave (m = 3, m = 4) and irregular wave (m = 4 ~ 5). The high-frequency mode is the combination of radial waves and azimuthal waves. New coupled patterns, such as one spiral wave with m = 1 azimuthal mode, two spiral waves with m = 2 azimuthal mode and annular radial wave, etc., are discovered. Different modes are growing, coupling and competing during the onset of oscillatory instability. As volume ratio is changing, the mode transition is found as a continuous process of competition, rather than an abrupt change with clear volume ratio boundary. Instability ; Azimuth ; Oscillation (cell signaling) ; Dynamic mode decomposition ; Mode (computer interface) ; Space (punctuation) ; Spiral (railway) ; Flow (mathematics) ; Wavenumber Solidification and crystal growth phenomena ; Fluid Dynamics and Thin Films ; Nonlinear Dynamics and Pattern Formation
Authors: Q. Liu | Jianmin Ling | Zhao Li | Lintao Bi
Source: Oncology Reports (review, 2025-07-02)
Field: Chemistry — Spectroscopy

Advances in lymphoma biomarkers research based on proteomics technology (Review) Lymphoma is a common malignancy characterized by diverse pathological types and marked heterogeneity. Distinct subtypes of lymphomas are markedly different in their clinical manifestations, treatment approaches and prognostic outcomes. With the rapid development of molecular biology techniques, antitumor research has stepped into an era of precision medicine. Biomarkers, with high sensitivity and specificity, are expected to function in early diagnosis, targeted treatment and prognostic estimation for cancer and enhance the survival rate and life quality of patients. In this regard, proteomics technology, with the capability to systematically identify and quantify the dynamic protein alterations in tissues or cells, thereby facilitating the discovery of novel tumor potential candidates, has attracted significant scientific attention. The present article aimed to review most up‑to‑date research progress of lymphoma‑related biomarkers discovered based on proteomics technology, focusing on the potential application of these markers in the diagnosis, therapy and prognosis of each lymphoma subtype, and discuss the role proteomics may serve in future development of lymphoma research and clinical practice. Proteomics ; Lymphoma ; Malignancy ; Cancer ; Molecular medicine ; Biology ; Bioinformatics ; Medicine ; Computational biology ; Pathology ; Cell cycle ; Internal medicine Advanced Proteomics Techniques and Applications ; Lymphoma Diagnosis and Treatment ; RNA modifications and cancer
Authors: Anca Dumitru | Bryan T. Wonski | Renée S. Cole | Mitchell R. Weaver | Kelsey C. Carpenter | Loay Kabbani | Mai T. Lam
Source: Frontiers in Transplantation (article, 2025-10-07)
Field: Materials Science — Biomaterials

Case Report: Lessons learned from large animal implantation of an all-natural tissue engineered vascular graft Cardiovascular disease continues to be the number one cause of morbidity and mortality across the world. Coronary artery bypass graft (CABG) procedures are the most commonly performed major surgery in the U.S. Grafts are difficult to source as patients do not have many sites from which to harvest donor tissues as autografts. Plastic grafts have issues of infection and are only used as a last resort. Tissue engineered vascular grafts have potential to solve the need for all-natural vascular grafts in the clinic. In this study, we evaluate the feasibility of a completely biological engineered vascular graft for implantation in a large animal model of a rabbit. An all-biological tissue engineered graft was grown in our laboratory, composed of a tunica adventitia derived from human dermal fibroblasts and a tunica media made from human aortic smooth muscle cells. The all-biological engineered graft exhibited the "look and feel" of a natural vessel. The engineered graft was implanted into the abdominal aorta of a New Zealand rabbit. The graft easily anastomosed to the native abdominal aorta and showed no leakages. Once reperfused, the graft was able to withstand blood flow briefly, prior to exhibiting dissection between the media and adventitia. Color doppler ultrasound showed flow through the abdominal aorta, however, not through the graft region due to the dissected layers creating a blockage. These results support a shift from the traditional paradigm of designing vascular grafts to mimic the multi-layered native structure. The two-layer engineered graft tested here exhibited dissection between the layers, a phenomenon that has yet to be reported in the field to our knowledge. Based on these findings, we recommend a single layer engineered graft to best prevent dissection. Adventitia ; Tunica media ; Abdominal aorta ; Dissection (medical) ; Vascular graft ; Abdominal aortic aneurysm ; Aorta ; Tissue engineering Electrospun Nanofibers in Biomedical Applications ; Tissue Engineering and Regenerative Medicine ; Infectious Aortic and Vascular Conditions
Authors: Xinchen Yu
Source: Environmental Progress & Sustainable Energy (article, 2025-07-20)
Field: Materials Science — Polymers and Plastics

Optimization of environmental performance in domestic tumble dryers: A proposed solution for sustainable textile drying Abstract The growing dependence on energy‐intensive household clothes dryers presents pressing sustainability challenges, while systematic investigations correlating operational parameters with quantifiable energy‐carbon tradeoffs are critically lacking. This study bridges this knowledge gap by investigating the energy and environmental performance of tumble drying through an experimental framework integrating textile properties, operational parameters, and drum geometry. A response surface methodology with 40 designed experimental conditions quantified specific moisture extraction rate, carbon footprint, and monetary utility cost. Multivariate analysis revealed four statistically significant determinants: drum speed (optimal at 1.5 m/s for falling textile motion), load size (3 kg balancing airflow efficiency), air mass flow rate (220 m 3 /h ensuring heat/mass transfer), and initial moisture content (lowered via mechanical dewatering). Through parameter optimization, an eco‐efficient drying procedure achieved 47.7% lower energy consumption, 55.4% higher specific moisture extraction rate, 70.9% reduced carbon emissions, and 77.9% lower monetary utility cost compared with conventional methods. These results highlight the importance of optimizing drying parameters to reduce environmental impact and operational costs. The study provides actionable insights for consumers to adopt sustainable laundry habits and for manufacturers to improve dryer designs. By bridging empirical data, technical optimization, and behavioral strategies, this work establishes a holistic framework for sustainable clothes drying, contributing to household carbon mitigation efforts. Textile ; Environmental science ; Process engineering ; Business ; Waste management ; Engineering ; Materials science ; Composite material Textile materials and evaluations