jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Mariana Druchok | Marjan Piponski | Mariana Horyn | Nadiya Zarivna | Liliya Logoyda
Source: ScienceRise Pharmaceutical Science (article, 2025-10-31)
Field: Chemistry — Spectroscopy

The usage of salts of chaotropic anions for the development of HPLC method for the simultaneous determination of cisplatin and carboplatin in model mixture The aim of the work was to develop an RP-HPLC method for the simultaneous determination of extremely polar and non-UV-absorbing chromophore molecules of cisplatin and carboplatin in a model mixture using salts of chaotropic anions, which can be used for single-analyte determination too. Material and methods: HPLC analysis was performed using Agilent 1260 and Shimadzu LC-2050C with diode array detector (DAD). Cisplatin and carboplation (purity ≥99% (HPLC)) were supplied from Sigma-Aldrich Chemicals Co. (St. Louis, MO, USA). Used dosage forms: cisplatin «Ebeve» (0.5 mg/ml, Austria) and carboplatin «Ebeve» (10 mg/ml, Austria). All used reagents were HPLC gradient chromatography quality and purchased from Merck Darmstadt, Germany. Results and discussion: Chaotropic agents enhance retention of basic molecules in acidic mobile phases on reversed-phase chromatographic columns and improve peak shape and symmetry. The chaotropic anions that increase interaction between the basic N-containing analyte and the alkyl chains of reversed-phase ligands, such as C-8 and C-18, are frequently employed to enhance and improve the performance of HPLC methods. The chromatographic analysis of cisplatin and carboplatin presented a unique challenge due to their inorganic structure. The experimentally established optimal chromatographic conditions are: mobile phase - 40 mM KPF6 buffer solution (pH 2.4) and ACN (95:5), chromatographic column - Luna C18 (100 x 4.6 mm 3 µm), column temperature - 30 °C, flow rate - 0.4 ml/min, detection wavelength - 210 nm. Linearity was assessed using five levels of each of the investigated drugs, where concentration varied in the range of 20–100 μg/mL. The proposed HPLC method is green, as confirmed by the most modern metrics for studying greenness (AGREE, MoGAPI, complex MoGAPI, AGSA, CaFRI and CACI). Conclusions. In this work, thorough scientific research was carried out with the presentation of HPLC method development for the simultaneous determination of extremely highly polar molecules cisplatin and carboplatin in a model mixture using salts of chaotropic anions. In addition, two studied drugs were quantified using rapid, simple, cost-effective HPLC method approaches Chaotropic agent ; High-performance liquid chromatography ; Carboplatin ; Analyte ; Cisplatin ; Acetonitrile ; Methanol ; Chromatography detector Analytical Chemistry and Chromatography ; Analytical Methods in Pharmaceuticals ; Analytical chemistry methods development
Authors: Na-Yeon Choi | Dong‐Seok Kim | Sung-Uk Zhang
Source: Polymers (article, 2025-08-27)
Field: Materials Science — Polymers and Plastics

Design-Oriented Degradation Mapping and Hyperelastic Model-Switch Guidelines for Nitrile-Butadiene Rubber Seals Nitrile-butadiene rubber (NBR) seals used in automotive and energy equipment undergo pronounced mechanical degradation at elevated temperatures, yet a quantitative rule for switching between hyperelastic models remains unclear. Here, accelerated thermal aging tests were linked to service conditions by estimating the activation energy via Flynn-Wall-Ozawa analysis and applying an Arrhenius-based equivalence. Tensile testing, dynamic mechanical analysis, and thermogravimetric analysis were combined to track embrittlement and crosslinking, and finite element simulations were benchmarked against experiments using an L2-norm metric. The outcome is a degradation map with a model-switching guideline. The Neo-Hookean model is preferred in the less-embrittled regime, whereas the five-parameter Mooney-Rivlin model is recommended as embrittlement progresses. This framework improves stress-prediction fidelity while keeping model complexity commensurate with the aging state, enabling faster and more reliable design of NBR seals for high-temperature automotive and renewable-energy applications. Hyperelastic material ; Degradation (telecommunications) ; Natural rubber ; Materials science ; Nitrile ; Ogden ; Composite material ; Computer science ; Structural engineering ; Finite element method ; Engineering ; Chemistry ; Organic chemistry Polymer Nanocomposites and Properties ; Tribology and Wear Analysis ; Orthopaedic implants and arthroplasty
Authors: Yu‐Chieh Chang | Tianqi Gu | Y. C. Li | T. Y. Chang | Chun‐Ta Wang
Source: Advanced Materials Interfaces (article, 2025-07-15)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Enhancing Diffraction Efficiency in Polarization Volume Gratings via Polymer‐Stabilized Cholesteric Liquid Crystal Bilayers Abstract Polarization volume gratings (PVGs), formed using patterned cholesteric liquid crystals (CLCs), offer high diffraction efficiency, polarization selectivity, and broad angular bandwidth—making them ideal for advanced photonic applications. However, traditional CLC‐based PVGs are intrinsically limited to a maximum reflectivity of 50% for unpolarized light, capping their diffraction efficiency. To overcome this limitation, a recently proposed approach is presented that achieves hyper‐reflectivity in a single polymer‐stabilized cholesteric liquid crystals CLC (PSCLC) cell using a bilayer helical structure fabricated via photo‐polymerization‐enforced stratification (PES). This method enables the coexistence of two CLC layers with orthogonal helical handedness, facilitating reflection of both left‐ and right‐handed circularly polarized light. Experimental results confirm that through precise material composition and photo‐polymerization processing, PVGs with either multi‐band reflection or high diffraction efficiency can be realized. Moreover, the bilayer architecture exhibits tunable optical behavior under electric fields and temperature variation, underscoring its potential in adaptive and reconfigurable optical systems. Materials science ; Liquid crystal ; Polymer ; Diffraction efficiency ; Diffraction ; Polarization (electrochemistry) ; Cholesteric liquid crystal ; Optics ; Chemical engineering ; Optoelectronics ; Grating ; Composite material ; Physical chemistry Liquid Crystal Research Advancements ; Optical Coatings and Gratings ; Photonic and Optical Devices
Authors: Nhung Thi Tran | Anh Tuan Nguyen Huynh
Source: Royal Society Open Science (article, 2025-12-01)
Field: Materials Science — Materials Chemistry

Incorporation of nitrogen-doped carbon dots synthesized from pomelo peels into poly(vinyl alcohol) as highly antioxidant and ultraviolet-blocking food packaging film Abstract Nitrogen-doped carbon dots (CDs) with sizes of 5–12 nm were synthesized via a facile hydrothermal method at 200°C for 12 h, using the albedo portion of pomelo peel waste as the carbon source and urea as the nitrogen dopant. Increasing the amount of urea (0.0–2.0 g) produced CDs with higher nitrogen-doping levels, leading to a blue shift in the absorption spectra, enhanced fluorescence intensity and an increase in zeta potential from −1.41 to −32.1 mV. The average quantum yield of the N-doped CDs was 43% higher than that of the undoped CDs (5.91% versus 4.12%). The effects of the CD types and contents on poly(vinyl alcohol) (PVA)-based films were investigated. A film containing 5% CDs synthesized with the addition of 1.0 g of urea showed a 26% increase in tensile strength, a 13.9% reduction in water swelling, a 26.5% decrease in water vapour transmission rate, and improved thermal stability compared with the pristine PVA film. Furthermore, the film incorporating N-doped CDs exhibited strong antioxidant activity, achieving up to 87% scavenging of 2,2-diphenyl-1-picrylhydrazyl radicals and superior ultraviolet (UV)-shielding performance (approx. 100% for UVB/UVC and &amp;gt;84% for UVA). Consequently, the composite film significantly outperformed commercial polyethylene film in extending the shelf-life of green plums under UV exposure, highlighting its potential as an antioxidant and UV-blocking material for active food packaging. Carbon fibers ; Zeta potential ; Antioxidant ; Thermal stability ; Fluorescence ; Ultraviolet ; Polyethylene glycol ; Food packaging Carbon and Quantum Dots Applications ; Nanocomposite Films for Food Packaging ; Advanced Cellulose Research Studies
Authors: Fajar Adinugraha | S. Zubaidah | Sri Rahayu Lestari
Source: Recoletos Multidisciplinary Research Journal (article, 2025-08-01)
Field: Chemistry — Inorganic Chemistry

An Ethnobiological Study of Indigenous Knowledge about the Traditional Production of Coconut Sugar Within the Somongari Javanese Community Background: Coconut sugar is a traditional product widely consumed in Indonesia, including by the Javanese community of Somongari. Despite its importance, the knowledge of coconut sugar production in Somongari remains undocumented, as it is passed down primarily through oral tradition. This study seeks to explore the traditional coconut sugar-making practices of the Somongari Javanese community from an ethnobiological perspective. Methods: This study employed a field exploration approach in Somongari Village, Indonesia, incorporating interviews, observation, and documentation. Twenty-four informants, comprising twenty sugar makers and four key informants, were interviewed. Results: Coconut sugar is produced from the sap of coconut flowers (sajeng) and is cooked until thickened and molded. The natural remedy used in the production of coconut sugar is laru. Laru comprises enjet (limestone) and lathi manggis (sap of mangosteens). The manufacturing process utilizes traditional tools and techniques, comprising three stages: ndewan (coconut sap collection), genen (cooking the coconut sap until it thickens), and nitis (molding the coconut sap). Conclusion: The indigenous knowledge of coconut sugar production embodies the close relationship between biodiversity and cultural heritage. The utilization of local plants contributes to both the production and consumption values, highlighting the need to preserve this practice through documentation and integration into educational and community learning to sustain ecological and cultural values. Sugar ; Indigenous ; Traditional knowledge ; Production (economics) ; Ethnobotany ; Product (mathematics) ; Biodiversity ; Documentation Coconut Research and Applications ; Forest Ecology and Conservation ; Agricultural and Environmental Management
Authors: Ivana Radojević | Katarina Ćirković | Marijana Vasić | Jelena Mladenović | Katarina Virijević | Marko Živanović
Source: Kragujevac Journal of Science (article, 2025-01-01)
Field: Materials Science — Biomaterials

Antimicrobial activity of nanofibers and methanol extract of Trapa natans L. Uncontrolled, routine use of antibiotics has led to the development of antibiotic resistance in microorganisms, which is a clinical problem of global proportions. Many plants have been recognized as a resource of natural antimicrobial compounds that can potentially be effective in the treatment of bacterial infections. At the same time, technological progress has enabled the application of new materials in the field of medicine, such as micro and nanofibers. Therefore, the aim of this research is to examine the antimicrobial activity of nanofibers fabricated via electrospinning of solutions containing methanolic extract of Trapa natans L. and antibiotics. To determine the antimicrobial activity the microdilution method and the welland disk-diffusion method were used. The results indicated a promising potential in achieving antimicrobial activity, both for the plant and for the combination of nanofibers. The methanol extract of T. natans showed the highest activity against Bacillus subtilis ATTC 6633, by the microdilution method, while by the disk-diffusion method, the submerged variant of the nanofibers showed a zone of inhibition against Staphylococcus aureus ATCC 25923, which was better than the nanofibers and the antibiotic in two of the three analyzed concentrations. Antimicrobial ; Nanofiber ; Broth microdilution ; Electrospinning ; Antibiotics ; Methanol Electrospun Nanofibers in Biomedical Applications ; Antimicrobial agents and applications ; Nanoparticles: synthesis and applications
Authors: Sibel Dikmen Küçük
Source: Düzce Üniversitesi Bilim ve Teknoloji Dergisi (article, 2025-10-30)
Field: Materials Science — Polymers and Plastics

Biodegradable CNFC/EPDM Green Composites: A Sustainable Alternative for Automotive Sealing Profiles Sustainable material development is one of the most researched topics in the automotive industry. Sealing profiles, which are indispensable components of automotive vehicles, contain many petroleum-based products which automotive manufacturers are working to replace with biodegradable materials. The aim of this study is to investigate the effect of carboxylated nanofibrillated cellulose (CNFC) on the ethylene propylene diene monomer (EPDM) rubber in terms of evaluation some properties such as mechanical, chemical, thermal, morphological, rheological, and deformation. The CNFC was added at levels of 1, 3, 5, and 10 parts per hundred parts of rubber (pphr) to the EPDM rubber compound instead of synthetic and petroleum-based EPDM to develop CNFC/EPDM green composites. The rheological results showed that the CNFC/EPDM green composites were still acceptable according to the strength specifications of automotive manufacturers. Despite some lower mechanical properties, CNFC addition up to 10 pphr was still a suitable replacement for EPDM because the values were within specifications of automotive manufacturers. However, when the CNFC was added at more than 3 pphr, the lifespan of the CNFC/EPDM green composites was limited to three years according to the weathering results. Automotive industry ; Natural rubber ; Raw material ; EPDM rubber ; Elastomer Polymer Nanocomposites and Properties ; Polymer Science and PVC ; Advanced Cellulose Research Studies
Authors: Yuanyuan Wu | Hui Huang | Xianglong Zhao | Jia-Yin Lin | Jialiang Guo | Zhengjin Jiang | Kesara Ar-sanork | Tao Deng | Dongsheng Xu
Source: Frontiers in Chemistry (review, 2025-10-01)
Field: Chemistry — Analytical Chemistry

Recent progress in the application of hydrophilic interaction liquid chromatography for the separation and analysis of traditional Chinese medicine Traditional Chinese medicine (TCM), with a history spanning over 2,000 years, contains numerous strongly polar components that are increasingly the focus of pharmaceutical and analytical research. However, conventional reversed-phase liquid chromatography usually fails to adequately retain and separate these highly polar components. Hydrophilic interaction liquid chromatography (HILIC) has emerged as a powerful complementary technique, offering improved retention and separation for polar analytes. In recent years, HILIC has seen rapid development and wide application in the analysis of TCM. This review summarizes the major types of HILIC stationary phases and their recent applications in the separation of polar components in TCM. Particular attention is given to the analysis, quality control, and metabolomic profiling of bioactive compounds such as flavonoids, alkaloids, and saponins, highlighting the increasingly important role of HILIC in promoting TCM research. Hydrophilic interaction chromatography ; Polar ; Chemical polarity ; Traditional Chinese medicine ; Profiling (computer programming) ; High-performance liquid chromatography Chromatography in Natural Products ; Analytical Chemistry and Chromatography ; Traditional Chinese Medicine Analysis
Authors: Juan David Rodríguez Macías | Oscar Saurith-Coronell | Laura Melissa Sinisterra Parra | Domingo César Carrascal-Hernández | Fabio Fuentes-Gandara | Daniel Insuasty | Edgar Márquez
Source: International Journal of Molecular Sciences (article, 2025-10-30)
Field: Materials Science — Biomaterials

Integrated In Vitro and In Silico Evaluation of the Antimicrobial and Cytotoxic Potential of Calotropis procera Leaf Ethanolic Extract: From GC-MS Profiling to Molecular Docking and Dynamics <i>Calotropis procera</i>, a drought-tolerant shrub widely used in folk medicine, was evaluated for its antimicrobial potential and safety using an integrative in vitro/in silico workflow. Ethanolic leaf extract (EE-CP) displayed a dose-dependent inhibition of <i>Staphylococcus aureus</i> ATCC 2913 and <i>Escherichia coli</i> ATCC 35218, reaching 93% and 52% of the amoxicillin control, respectively (MIC 207 µg mL<sup>-1</sup> and 149 µg mL<sup>-1</sup>). GC-MS and LC-HRMS profiling revealed cardenolides (strophanthidin, gitoxigenin) and indole derivatives as major constituents. Pharmacophore mapping highlighted the essential glycosyltransferase MurG as a likely bacterial target; molecular docking showed that strophanthidin and NCGC00384918 bind MurG more strongly than the native substrate UDP-GlcNAc (ΔG ≤ -9.4 kcal mol<sup>-1</sup>), a result corroborated by 100 ns molecular dynamics simulations and MM-PBSA binding energies (-96.4 and -49.3 kcal mol<sup>-1</sup>). EE-CP caused <10% hemolysis up to 1.5 mg mL<sup>-1</sup> and exhibited LC<sub>50</sub> values of 302 µg mL<sup>-1</sup> (human lymphocytes) and 247 µg mL<sup>-1</sup> (BHK-21 cells), indicating a narrow but exploitable therapeutic window. Collectively, these findings constitute the first report on Colombian <i>C. procera</i> demonstrating potent anti-<i>Staphylococcus</i> activity, MurG-targeted cardenolides, and acceptable erythrocyte compatibility. This study supports EE-CP as a promising source of lead molecules and antibiotic adjuvants, warranting guided fractionation and in vivo validation to optimize efficacy and mitigate cytotoxicity. In silico ; Phenylethanoid ; Antimicrobial ; Pharmacophore ; Calotropis procera ; Hemolysis ; Docking (animal) Phytochemistry and Bioactive Compounds ; Phytochemistry and Biological Activities ; Phytochemicals and Medicinal Plants
Authors: Kavya Anguluri | Saman Bagherpour | Ana Cristina Calpena | Lyda Halbaut | Alba Espargaró | Raimon Sabaté | Lluïsa Pérez‐García
Source: Preprints.org (preprint, 2025-11-20)
Field: Materials Science — Biomaterials

Rose Bengal-Incorporated Supramolecular Gels as a Topical Platform for Localized Antimicrobial Photodynamic Therapy Efficient and localized singlet oxygen (SO) generation is essential for improving antimicrobial photodynamic therapy (aPDT). In this study, a bis-imidazolium-based amphiphilic gelator is used that self-assembles into a supramolecular gel in a water–ethanol medium and incorporates Rose Bengal (RB) as a photosensitizer. The gel network provides a confined environment that promotes SO formation under light irradiation. RB@Gel was characterized with respect to its morphology, degradation behavior, and swelling properties. Biopharmaceutical assessment included in-vitro release, ex-vivo permeation studies and Hen’s Egg Test–Chorioallantoic Membrane (HET-CAM) assay. Rheological measurements confirmed a viscoelastic profile, indicating structural stability and suitability for localized therapeutic applications. SO production within the gel was quantified using tetrasodium 9,10-anthracenediyl-bis(methylene)dimalonate (NaABMA), showing higher efficiency than that of RB in solution. The RB@Gel exhibited significant aPDT against E. coli in a direct-surface contact assay. Overall, the RB@Gel provides a stable, suitable platform capable of efficient SO generation and potent antibacterial activity, highlighting its promise for localized aPDT applications. Singlet oxygen ; Photodynamic therapy ; Rose bengal ; Antimicrobial ; Permeation ; Supramolecular chemistry Supramolecular Self-Assembly in Materials ; Nanoplatforms for cancer theranostics ; Graphene and Nanomaterials Applications
Authors: Lukman Hadi | Ahmad Mudzakir | Yuli Rahmawati
Source: Jurnal Penelitian Pendidikan IPA (article, 2025-09-25)
Field: Chemistry — Physical and Theoretical Chemistry

Course-Based Undergraduate Research Experiences (CUREs) in Chemistry Education: Characteristics, Implementation, and Impact Course-Based Undergraduate Research Experiences (CUREs) have gained increasing prominence as an innovative pedagogical model that integrates authentic research into the undergraduate curriculum. While extensive research has highlighted the general benefits of CUREs across STEM fields, a focused synthesis of their implementation and impact specifically within chemistry education remains underexplored. This narrative review addresses this gap by analyzing ten recent, peer-reviewed studies indexed in Scopus to characterize how CUREs are designed, implemented, and evaluated in undergraduate chemistry contexts. The findings demonstrate that CUREs shift traditional laboratory instruction toward inquiry-based, authentic research experiences that foster critical thinking, increase student engagement, and enhance retention in STEM, especially within inclusive learning environments. However, challenges such as faculty workload, scalability, and research output persist. By consolidating insights across current literature, this review contributes a field-specific understanding of CUREs in chemistry education and offers implications for curriculum design, institutional support, and future research directions. In doing so, it fills a critical gap in the literature and underscores the evolving role of CUREs in preparing the next generation of chemists through evidence-based, research-intensive teaching practices. Undergraduate research ; Curriculum ; Undergraduate education ; Chemistry education ; Narrative ; Higher education ; Curriculum development Various Chemistry Research Topics ; Science Education and Pedagogy ; Career Development and Diversity
Source: Advanced Electronic Materials (article, 2025-01-01)
Field: Materials Science — Materials Chemistry

Celebrating a Decade of Excellence and Innovation at Advanced Electronic Materials As we mark the 10th anniversary of Advanced Electronic Materials, it is an ideal moment to pause and reflect on the incredible journey that has shaped this journal into a leading platform for innovation and cutting-edge research in the field of electronic materials.From its humble beginnings in 2015 to its current position as one of the most respected journals in the field, the past decade has been one of extraordinary growth, collaboration, and scientific advancement.In particular, as a platform for publishing significant studies on the design, fabrication, and application of electronic materials in emerging technologies, the journal serves a broad geographical authorship covering a wide spectrum of topics. Excellence ; Materials science ; Electronic materials ; Nanotechnology ; Engineering ethics ; Engineering physics ; Engineering ; Political science Electronic and Structural Properties of Oxides ; Semiconductor materials and devices ; Nanowire Synthesis and Applications
Authors: 胡莉 Hu Li | 席锋 Xi Feng | 代洪霞 Dai Hongxia
Source: Acta Optica Sinica (article, 2025-01-01)
Field: Materials Science — Materials Chemistry

非手性锗纳米块二聚体超表面的手性近场响应 超表面的手性近场响应能够有效地增加手性分子与光波的相互作用。从理论上探讨结构简单的非手性锗纳米块二聚体置于有石墨烯薄膜的基底上时，通过线偏光激发，在中红外波段实现的大体积、强烈的单手性近场响应。该近场响应的手性可以通过调节入射光偏振方向灵活翻转。基于有限元分析法的COMSOL软件数值模拟结果显示：该超表面基于Mie共振机制，能够同时产生电偶极和磁偶极共振，且电场和磁场增强谱的峰位基本重合；在6.082 μm和6.175 μm处呈现出显著的手性近场增加，两个纳米块之间的平均手性近场增加分别达到59.46和819.18。模拟近场分布显示，手性近场增加主要集中在两个纳米块之间，呈单一手性且分布较均匀。进一步对比分析表明，引入石墨烯薄膜不仅显著提升手性近场响应，还可通过改变其费米能级实现动态调节。同时，该手性近场响应的强度和波段可以通过锗纳米块的几何尺寸加以调节。该研究为在中红外波段实现手性分子的识别、传感和检测等应用提供理论参考。 Computer science Graphene research and applications ; Metamaterials and Metasurfaces Applications ; Graphene and Nanomaterials Applications