jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Hiroshi Masai | Tomoki Nakagawa | Jun Terao
Source: Polymer Journal (article, 2024-01-16)
Field: Materials Science — Materials Chemistry

Recent progress in photoreactive crosslinkers in polymer network materials toward advanced photocontrollability Abstract Photochemically adaptable polymer materials, which change shape and physical properties under light irradiation, are widely used in the fields of medicine, electronics, and engineering due to their precise and remote processability. This processability is attributed to the photocleavage of chemical bonds introduced into the polymer materials. In particular, the efficient photolytic cleavage of the crosslinking points in the network induces rapid softening and degradation of the materials. Recently, diverse designs of light-responsive units have been developed to fabricate various photocontrollable materials with low-energy, rapid, and reversible photoreactivity. Furthermore, multiple stimuli-responsive materials have been demonstrated to control photodegradation reaction rates and photoreactivity by combining light with another stimulus, leading to advanced photocontrollable capabilities. This paper reviews the recent progress in developing photochemically adaptable polymer network materials by designing photoresponsive units, focusing on the chemical structures of cleavable moieties. Polymer ; Materials science ; Photodegradation ; Nanotechnology ; Polymer network ; Electronics ; Irradiation ; Photochemistry ; Chemistry ; Organic chemistry ; Catalysis ; Photocatalysis ; Composite material Photochromic and Fluorescence Chemistry ; Photopolymerization techniques and applications ; Advanced Polymer Synthesis and Characterization
Authors: Fawad Islam | Qingle Zeng
Source: Polymers (article, 2024-04-25)
Field: Materials Science — Polymers and Plastics

Advances in Organosulfur-Based Polymers for Drug Delivery Systems Organosulfur-based polymers have unique properties that make them useful for targeted and managed drug delivery, which can improve therapy while reducing side effects. This work aims to provide a brief review of the synthesis strategies, characterization techniques, and packages of organosulfur-based polymers in drug delivery. More importantly, this work discusses the characterization, biocompatibility, controlled release, nanotechnology, and targeted therapeutic aspects of these important structural units. This review provides not only a good comprehension of organosulfur-based polymers but also an insightful discussion of potential future prospectives in research. The discovery of novel organosulfur polymers and innovations is highly expected to be stimulated in order to synthesize polymer prototypes with increased functional accuracy, efficiency, and low cost for many industrial applications. Organosulfur compounds ; Nanotechnology ; Drug delivery ; Biocompatibility ; Polymer ; Materials science ; Biochemical engineering ; Chemistry ; Organic chemistry ; Engineering ; Sulfur Synthesis and properties of polymers ; Chemical Synthesis and Reactions ; Antimicrobial agents and applications
Authors: Godwin K. Babanyinah | Abhi Bhadran | Himanshu Polara | Hanghang Wang | Tejas Shah | Michael C. Biewer | Mihaela C. Stefan
Source: Chemical Science (article, 2024-01-01)
Field: Materials Science — Biomaterials

Maleimide functionalized polycaprolactone micelles for glutathione quenching and doxorubicin delivery High glutathione production is known to be one of the defense mechanisms by which many cancer cells survive elevated oxidative stress. By explicitly targeting glutathione in these cancer cells and diminishing its levels, oxidative stress can be intensified, ultimately triggering apoptosis or programmed cell death. Herein, we developed a novel approach by creating maleimide-functionalized polycaprolactone polymers, specifically using 2,3-diiodomaleimide functionality to reduce the level of glutathione in cancer cells. Polycaprolactone was chosen to conjugate the 2,3-diiodomaleimide functionality due to its biodegradable and biocompatible properties. The amphiphilic block copolymer was synthesized using PEG as a macroinitiator to make corresponding polymeric micelles. The resulting 2,3-diiodomaleimide-conjugated polycaprolactone micelles effectively quenched glutathione, even at low concentrations (0.01 mg mL<sup>-1</sup>). Furthermore, we loaded these micelles with the anticancer drug doxorubicin (DOX), which exhibited pH-dependent drug release. We obtained a loading capacity (LC) of 3.5% for the micelles, one of the highest LC reported among functional PCL-based micelles. Moreover, the enhanced LC doesn't affect their release profile. Cytotoxicity experiments demonstrated that empty and DOX-loaded micelles inhibited cancer cell growth, with the DOX-loaded micelles displaying the highest cytotoxicity. The ability of the polymer to quench intracellular GSH was also confirmed. This approach of attaching maleimide to polycaprolactone polymers shows promise in depleting elevated glutathione levels in cancer cells, potentially improving cancer treatment efficacy. Maleimide ; Polycaprolactone ; Doxorubicin ; Glutathione ; Micelle ; Quenching (fluorescence) ; Chemistry ; Combinatorial chemistry ; Polymer chemistry ; Organic chemistry ; Medicine ; Internal medicine ; Chemotherapy ; Polymer Nanoparticle-Based Drug Delivery ; Nanoplatforms for cancer theranostics ; Graphene and Nanomaterials Applications
Authors: Mohammed G. Kotp | Shiao‐Wei Kuo
Source: Polymers (article, 2024-06-21)
Field: Materials Science — Materials Chemistry

Selective Capturing of the CO2 Emissions Utilizing Ecological (3-Mercaptopropyl)trimethoxysilane-Coated Porous Organic Polymers in Composite Materials Capturing carbon dioxide (CO<sub>2</sub>) is still a major obstacle in the fight against climate change and the reduction of greenhouse gas emissions. To address this problem, we employed a simple Friedel-Crafts alkylation to investigate the effectiveness of porous organic polymers (POPs) based on triphenylamine (TPA) and trihydroxy aryl terms derived from chloranil (CH), designated as TPA-CH POP. We then treated the TPA-CH POP with (3-mercaptopropyl)trimethoxysilane (3-MPTS), forming a TPA-CH POP-SH nanocomposite to enhance CO<sub>2</sub> capture. Utilizing FTIR, solid-state NMR, SEM, TEM, along with XPS techniques, the molecular makeup, morphological characteristics, as well as physical features of TPA-CH POP and the TPA-CH POP-SH nanocomposite were thoroughly explored. Upon scorching to 800 °C, the TPA-CH POP-SH nanocomposite demonstrated more thermal durability over TPA-CH POP, achieving a char yield of up to 71.5 wt.%. The TPA-CH POP-SH nanocomposite displayed a 2.5-times better CO<sub>2</sub> capture, as well as a comparable adsorption capacity of 48.07 cm<sup>3</sup> g<sup>-1</sup> at 273 K. Additionally, we found that the TPA-CH POP-SH nanocomposite exhibited an improved CO<sub>2</sub>/nitrogen (N<sub>2</sub>) selectivity versus the original TPA-CH POP. Typical enthalpy changes for CO<sub>2</sub> capture were somewhat increased by the 3-MPTS coating, indicating greater binding energies between CO<sub>2</sub> molecules and the adsorbent surface. Our outcomes demonstrate that a TPA-CH POP composite coated with MPTS is a viable candidate for effective CO<sub>2</sub> capture uses. Our findings encourage the investigation of different functional groups and optimization strategies. Nanocomposite ; Chemical engineering ; Adsorption ; Polymer ; Materials science ; Fourier transform infrared spectroscopy ; Composite number ; Chemistry ; Organic chemistry ; Nanotechnology ; Composite material Covalent Organic Framework Applications ; Metal-Organic Frameworks: Synthesis and Applications ; Carbon Dioxide Capture Technologies
Authors: Ben. J. Tickner | Marcus Dennington | Benjamin G. Collins | Callum A. Gater | Theo F. N. Tanner | Adrian C. Whitwood | Peter J. Rayner | D. P. Watts | Simon B. Duckett
Source: ACS Catalysis (article, 2024-01-05)
Field: Chemistry — Spectroscopy

Metal-Mediated Catalytic Polarization Transfer from <i>para</i> Hydrogen to 3,5-Dihalogenated Pyridines The neutral catalysts [IrCl(H)<sub>2</sub>(NHC)(substrate)<sub>2</sub>] or [IrCl(H)<sub>2</sub>(NHC)(substrate)(sulfoxide)] are used to transfer polarization from <i>para</i> hydrogen (<i>p</i>H<sub>2</sub>) to 3,5-dichloropyridine and 3,5-dibromopyridine substrates. This is achieved in a rapid, reversible, and low-cost process that relies on ligand exchange within the active catalyst. Notably, the sulfoxide-containing catalyst systems produced NMR signal enhancements between 1 and 2 orders of magnitude larger than its unmodified counterpart. Consequently, this signal amplification by reversible exchange hyperpolarization method can boost the <sup>1</sup>H, <sup>13</sup>C, and <sup>15</sup>N nuclear magnetic resonance (NMR) signal intensities by factors up to 4350, 1550, and 46,600, respectively (14.0, 1.3, and 15.4% polarization). In this paper, NMR and X-ray crystallography are used to map the evolution of catalytically important species and provide mechanistic rational for catalytic efficiency. Furthermore, applications in spontaneous radiofrequency amplification by stimulated emission and NMR reaction monitoring are also shown. Catalysis ; Spin isomers of hydrogen ; Chemistry ; Polarization (electrochemistry) ; Sulfoxide ; Hyperpolarization (physics) ; Metal ; Dimethyl sulfoxide ; Ligand (biochemistry) ; Nuclear magnetic resonance spectroscopy ; Induced polarization ; Photochemistry ; Hydrogen ; Physical chemistry ; Stereochemistry ; Organic chemistry ; Physics Advanced NMR Techniques and Applications ; Atomic and Subatomic Physics Research ; Solid-state spectroscopy and crystallography
Authors: Yali Feng | Bowen Zhang | Youzhi Xu | Shengnan Jin | Daniele Mazzarella | Zhong-Yan Cao
Source: Organic Chemistry Frontiers (article, 2024-01-01)
Field: Chemistry — Organic Chemistry

The reactivity of alkenyl boron reagents in catalytic reactions: recent advances and perspectives Recent advances focusing on novel reactivity of alkenyl boron reagents in polar or radical pathways within catalytic reactions by employing transition metal catalysis, organocatalysis have been summarized and discussed. Chemistry ; Reactivity (psychology) ; Boron ; Reagent ; Catalysis ; Organic chemistry ; Combinatorial chemistry Organoboron and organosilicon chemistry ; Boron Compounds in Chemistry ; Asymmetric Hydrogenation and Catalysis
Authors: Fatima Zohra Charik | Brahim Achiou | Abdessamad Belgada | Mohamed Ouammou | Murielle Rabiller‐Baudry | Saâd Alami Younssi
Source: Journal of environmental chemical engineering (article, 2024-05-03)
Field: Chemistry — Inorganic Chemistry

In-depth exploration of defects in zeolite membranes: Typology, formation, characterization and healing Membrane ; Characterization (materials science) ; Zeolite ; Materials science ; Nanotechnology ; Crystallization ; Biochemical engineering ; Chemistry ; Chemical engineering ; Engineering ; Catalysis ; Organic chemistry Zeolite Catalysis and Synthesis ; Covalent Organic Framework Applications ; Metal-Organic Frameworks: Synthesis and Applications
Authors: Yuejiang Han | Lin Liu | Zheng‐Bo Han | Mingyan Wu
Source: Separation and Purification Technology (article, 2024-03-05)
Field: Chemistry — Inorganic Chemistry

Engineering ethane-trapping metal-organic framework for efficient ethylene separation under high humid conditions Ethylene ; Trapping ; Separation (statistics) ; Metal ; Metal-organic framework ; Chemistry ; Chemical engineering ; Materials science ; Environmental science ; Organic chemistry ; Engineering ; Catalysis ; Computer science ; Adsorption Metal-Organic Frameworks: Synthesis and Applications ; Covalent Organic Framework Applications ; Sulfur Compounds in Biology
Authors: Hanghang Wang | Himanshu Polara | Abhi Bhadran | Tejas Shah | Godwin Kweku Babanyinah | Ziyuan Ma | Erika L. Calubaquib | Justin T. Miller | Michael C. Biewer | Mihaela C. Stefan
Source: Frontiers in Pharmacology (article, 2024-03-04)
Field: Materials Science — Biomaterials

Effect of aromatic substituents on thermoresponsive functional polycaprolactone micellar carriers for doxorubicin delivery Amphiphilic functional polycaprolactone (PCL) diblock copolymers are excellent candidates for micellar drug delivery. The functional groups on the backbone significantly affect the properties of PCL. A systematic investigation of the effect of aromatic substituents on the self-assembly of γ-functionalized PCLs and the delivery of doxorubicin (DOX) is presented in this work. Three thermoresponsive amphiphilic diblock copolymers with poly(γ-benzyloxy-ε-caprolactone) (PBnCL), poly(γ-phenyl- ε-caprolactone) (PPhCL), poly(γ-(4-ethoxyphenyl)-ε-caprolactone) (PEtOPhCL), respectively, as hydrophobic block and γ-tri(ethylene glycol) functionalized PCL (PME<sub>3</sub>CL) as hydrophilic block were prepared through ring-opening polymerization (ROP). The thermoresponsivity, thermodynamic stability, micelle size, morphology, DOX-loading, and release profile were determined. The LCST values of amphiphilic diblock copolymers PME<sub>3</sub>CL-<i>b</i>-PBnCL, PME<sub>3</sub>CL-<i>b</i>-PPhCL, and PME<sub>3</sub>CL-<i>b</i>-PEtOPhCL are 74.2°C, 43.3°C, and 37.3°C, respectively. All three copolymers formed spherical micelles in phosphate-buffered saline (PBS, 1×, pH = 7.4) at low concentrations ranging from 8.7 × 10<sup>-4</sup> g/L to 8.9 × 10<sup>-4</sup> g/L. PME<sub>3</sub>CL-<i>b</i>-PBnCL micelles showed the highest DOX loading capacity of 3.01 ± 0.18 (wt%) and the lowest drug release, while PME<sub>3</sub>CL-<i>b</i>-PEtOPhCL micelles exhibited the lowest DOX loading capacity of 1.95 ± 0.05 (wt%) and the highest drug release. Cytotoxicity and cellular uptake of all three micelles were assessed <i>in vitro</i> using MDA-MB-231 breast cancer cells. All three empty micelles did not show significant toxicity to the cells at concentrations high up to 0.5 mg/mL. All three DOX-loaded micelles were uptaken into the cells, and DOX was internalized into the nucleus of the cells. Micelle ; Polycaprolactone ; Copolymer ; Amphiphile ; Critical micelle concentration ; Chemistry ; Lower critical solution temperature ; Ethylene glycol ; Polymer chemistry ; Ring-opening polymerization ; Polymerization ; Nuclear chemistry ; Doxorubicin ; Drug delivery ; Organic chemistry ; Aqueous solution ; Polymer biodegradable polymer synthesis and properties ; Advanced Polymer Synthesis and Characterization ; Nanoparticle-Based Drug Delivery
Authors: Craig W. Stocker | Vanessa Wong | Antonio F. Patti | Gil Garnier
Source: Chemical and Biological Technologies in Agriculture (article, 2024-01-22)
Field: Materials Science — Biomaterials

Effect of lignin in cellulose nanofibers on biodegradation and seed germination Abstract Pure cellulose nanofibers (CNFs) rapidly degrade in soil, limiting their prospective applications in agriculture. We incorporated lignin into CNFs as an antimicrobial and crosslinking agent to control the biodegradation rate. CNFs with different lignin concentrations were prepared by mechanochemical treatment in the presence of choline chloride-urea deep eutectic solvent. These were characterized using conductometric titration, scanning electron microscopy, and FT-IR. The fibers were applied to soil to determine the effect of lignin on soil respiration and nanocellulose degradation, and were used as a substrate for radish and cress seed germination. Modifying the lignin content of the fibers successfully modulated the biodegradation rate in soil. Fibers containing 35% lignin degraded 5.7% in 14 days, while fibers with 20% lignin degraded 20.8% in 14 days. Nanofiber suspensions showed low chemical inhibition for the germination of radish and cress seeds but higher lignin contents reduced the imbibition rate as a seed coating. This study presents the first use of lignin to control the biodegradation rate of cellulose nanofibers in a one-pot, scalable and sustainable system, allowing the advancement of lignocellulose nanofibers for applications such as seed coatings, mulches, and controlled release fertilizers. Graphical Abstract Lignin ; Biodegradation ; Cellulose ; Nanofiber ; Materials science ; Chemical engineering ; Chemistry ; Nanocellulose ; Organic chemistry ; Composite material Advanced Cellulose Research Studies ; Enzyme-mediated dye degradation ; Electrospun Nanofibers in Biomedical Applications
Authors: Ioannis Α. Kartsonakis | Artemis Kontiza | Irene A. Kanellopoulou
Source: Preprints.org (preprint, 2024-08-06)
Field: Materials Science — Polymers and Plastics

Advanced Micro/Nanocapsules for Self-Healing Coatings The concept of intelligence has many applications, such as coatings and cyber security. Smart coatings have the ability to sense and/or response to external stimuli and generally interact with their environment. Self-healing coatings represent a significant advance in improving material durability and performance using microcapsules and nanocontainers loaded with self-healing agents, catalysts, corrosion inhibitors, and water-repellents. These smart coatings can repair damage on their own and restore mechanical properties without external intervention and are inspired by biological systems. Properties that are affected by either momentary or continuous external stimuli in smart coatings can be related to corrosion, fouling, fungal, self-healing, pie-zoelectric, microbiological, etc. These coating properties can be obtained via combinations of either organic or inorganic polymer phases, additives and pigments. In this article, a review on the advancements of micro/nanocapsules for self-healing coatings is reported from the aspect of ex-trinsic self-healing ability. The concept of extrinsic self-healing coatings is based on the use of capsules or multichannel vascular systems loaded with healing agents/inhibitors. The outcome is that self-healing coatings exhibit improved properties compared to traditional coatings. It is mentioned that self-healing anticorrosive coating not only has enhanced passive barrier function, but also realizes active defense. As a result, there is a significant improvement of the service life and overall performance of the coating. Future research should be devoted to refining self-healing mechanisms and developing cost-effective solutions for a wide range of industrial applications. Nanocapsules ; Self-healing ; Nanotechnology ; Materials science ; Medicine ; Nanoparticle Polymer composites and self-healing ; Dendrimers and Hyperbranched Polymers ; Tribology and Wear Analysis
Authors: Martín Castillo-Santillán | Priscila Quiñonez-Ángulo | Dina Maniar | José R. Torres‐Lubián | Marı́a C. Gutiérrez | Théophile Pelras | Albert J. J. Woortman | Qi Chen | María G. Pérez‐García | Katja Loos | Josué D. Mota‐Morales
Source: RSC Applied Polymers (article, 2024-01-01)
Field: Materials Science — Biomaterials

Ring-opening polymerization of emulsion-templated deep eutectic system monomer for macroporous polyesters with controlled degradability Biodegradable polyesters with interconnected macroporosity, such as poly(l-lactide) (PLLA) and poly(ε-caprolactone) (PCL), have gained significant importance in the fields of tissue engineering and separation. This study introduces functional macroinitiators, specifically polycaprolactone triol (PCL<sub>T</sub>) and polyethylene glycol (PEG), both OH-terminated, in the solventless ring-opening polymerization (ROP) of a liquid deep eutectic system monomer (DESm) composed of LLA and CL at a 30 : 70 molar ratio, respectively. The macroinitiators selectively initiate the organocatalyzed ROP of LLA in the DESm during the first polymerization stage, thereby modifying the PLLA architecture. This results in the formation of either branched or linear PLLA copolymers depending on the macroinitiator, PCL<sub>T</sub> and PEG, respectively. In the second stage, the ROP of the CL, which is a counterpart of the DESm, produces PCL that blends with the previously formed PLLA. The insights gained into the PLLA architectures during the first stage of the DESm ROP, along with the overall molecular weight and hydrophobicity of the resulting PLLA/PCL blend in bulk, were advantageously used to design polymerizable high internal phase emulsions (HIPEs) oil-in-DESm. By incorporating a liquid mixture of DESm and macroinitiators (PCL<sub>T</sub> or PEG), stable HIPE formulations were achieved. These emulsions sustained the efficient organocatalyzed ROP of the continuous phase at 37 °C with high conversions. The resulting polymer replicas of the HIPEs, characterized by macroporous and interconnected structures, were subjected to a degradation assay in PBS at pH 7.4 and 37 °C and remained mechanically stable for at least 30 days. Notably, they exhibited the capability to sorb crude oil in a proof-of-concept test, with a rate of 2 g g<sup>-1</sup>. The macroporous and interconnected features of the polyHIPEs, combined with their inherent degradation properties, position them as promising degradable polymeric sorbents for efficient separation of hydrophobic fluids from water. Polyester ; Monomer ; Emulsion ; Eutectic system ; Polymerization ; Emulsion polymerization ; Chemical engineering ; Materials science ; Polymer chemistry ; Ring (chemistry) ; Chemistry ; Organic chemistry ; Polymer ; Composite material ; Microstructure biodegradable polymer synthesis and properties ; Advanced Polymer Synthesis and Characterization ; Carbon dioxide utilization in catalysis
Authors: Naznin Sultana | A.P. Cole | Francine Stratchan
Source: Preprints.org (preprint, 2024-10-28)
Field: Materials Science — Biomaterials

Review: Biocomposite Scaffolds for Tissue Engineering: Materials, Fabrication Techniques and Future Directions Tissue engineering is an interdisciplinary field that combines methods, materials, and biological molecules to fabricate newly formed tissues to replace or restore functional organs. Biomaterials-based scaffolds play a vital role in developing new tissue by interacting with human cells. Tissue Engineering scaffolds with ideal characteristics, namely, nontoxicity, biodegradability, and appropriate mechanical and surface properties, are vital for tissue regeneration applications. Although commonly utilized biomaterials can provide physical and chemical properties needed for tissue regeneration, inadequate biomimetic properties, as well as insufficient interactions of cells-scaffolds interaction, still need to be improved for the application of tissue engineering in vivo. Consequently, developing innovative biomaterials-based stimulus-responsive 3D scaffolds that can enhance the mediators of cell adhesion and cellular functioning and that can form functional tissues by providing structural integrity within an appropriate time is much needed. It is possible to achieve some essential features using a single material, so combining two or more materials may fulfill the requirements. In order to achieve a proper scaffold design, a suitable fabrication technique and combination of biomaterials with controlled micro or nanostructures are needed to achieve the proper biological responses. This review highlights the natural polymers, smart materials, and recent advanced techniques currently used to create emerging scaffolds for tissue regeneration applications. Biocomposite ; Fabrication ; Nanotechnology ; Tissue engineering ; Engineering ; Materials science ; Construction engineering ; Biomedical engineering ; Composite material ; Medicine ; Pathology ; Composite number Electrospun Nanofibers in Biomedical Applications