jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Kairat Ospanov | Dariusz Andraka | Manat Alzhigitova | Bakhtiyar Kabylbekov | Гулбану Муханова
Source: Technobius (article, 2025-09-02)
Field: Materials Science — Materials Chemistry

Utilization of water treatment plant sludge in concrete mix This article presents the results of research on the processing of sludge generated at the Main Treatment Facilities (MTF) of Almaty, Kazakhstan, for use in concrete mixes. A nominal concrete mix composition was selected for sample production, consisting of Portland cement, crushed stone, sand, water, Interplast AT superplasticizer, and sludge from the horizontal settling tanks of the MTF. Samples were tested for compressive and flexural strength, water absorption, permeability, and density, revealing that replacing 5% sand with MTF sludge decreases compressive and flexural strengths at 28 days by 13.3% and 3.7%, respectively. In terms of water absorption, the best performance was observed in the sample containing 10% sludge from the MTF replacing part of the sand. Environmental science ; Waste management ; Water treatment ; Environmental engineering ; Engineering Magnesium Oxide Properties and Applications ; Concrete and Cement Materials Research ; Innovations in Concrete and Construction Materials
Authors: Lilong Wei | Rui Xiao | Zhengguang Guo | Pengpeng Wang | Kexin Zhao | Yun Zhou | Wei Sun | Yongtong Cao
Source: Frontiers in Oncology (article, 2025-04-08)
Field: Chemistry — Spectroscopy

Comparative urine proteomic study involving papillary thyroid carcinoma and benign thyroid nodules Overall, 2,479 proteins were used for quantitative analysis. Compared with benign nodules, papillary carcinomas showed significant increases and decreases in the levels of 169 and 27 proteins, respectively. Neck and thyroid tumors were enriched in the disease or function category. More than 100 proteins showed good performance in the area under the receiver operating characteristic curve (>0.8) upon MS validation. Semaphorin-6D showed good performance (AUC = 0.763) in ELISA validation. Urine proteomics is an effective diagnostic tool for distinguishing benign and malignant thyroid diseases. Semaphorin-6D may serve as a disease marker for large-scale validation and use. Additionally, this study identified potential biomarkers that warrant further investigation. Thyroid nodules ; Medicine ; Thyroid carcinoma ; Thyroid ; Pathology ; Papillary carcinoma ; Urine ; Internal medicine Advanced Proteomics Techniques and Applications ; Thyroid Cancer Diagnosis and Treatment ; Cancer-related Molecular Pathways
Authors: Aglaia Liopa-Tsakalidi | Helen Kalorizou | Vasiliki Gana | Kyriaki G. Zinoviadou | George Boskou
Source: International Journal of Agriculture and Environmental Research (article, 2025-01-01)
Field: Chemistry — Organic Chemistry

BIOFUNCTIONAL FOOD PRODUCTION FROM SMART ORGANIC TABLE OLIVE FARMS This study investigates the integration of smart sensor technologies into organic table olive farming to enhance the production of biofunctional olive foods and develop novel vegan products. The research was conducted on two organic olive farms in Messolonghi, Greece, utilizing Sentek Drill &amp; Drop sensors to monitor soil moisture, temperature, and salinity at multiple depths. An integrated supply chain data management system was implemented, and three new olive-based products were developed (semolina-olive pasta, olive instant soup mix, and savory energy bar). Smart soil monitoring enabled real-time optimization of irrigation and nutrient management while adhering to organic farming principles. The integrated approach successfully combined the four IFOAM principles (Health, Ecology, Justice, and Care) with modern technology. All three developed products met nutritional claim criteria (low in saturated fats, high in fiber and proteins). Water activity levels (0.442-0.625) allowed storage at room temperature. This study demonstrates that combining organic farming practices with smart sensor technology creates a scalable model for sustainable, high-quality olive production that meets both ecological and nutritional objectives, setting new standards for modern organic agriculture. This research bridges the gap between traditional organic farming and functional food production through technological innovation while maintaining environmental sustainability. Organic farming ; Agriculture ; Production (economics) ; Food processing ; Integrated production ; Food systems Edible Oils Quality and Analysis ; Medicinal Plants and Neuroprotection
Authors: Dragos Gabriel Zisopol | Mihail Minescu | Vasile Nastasescu | Dragoș Valentin Iacob
Source: Annals of Computer Science and Information Systems (article, 2025-12-10)
Field: Materials Science — Polymers and Plastics

Study on the influence of heat treatment on the mechanical tensile characteristics of parts additively manufactured by thermoplastic extrusion of PETG Extrusion ; Thermoplastic ; Ultimate tensile strength ; Thermoplastic composites ; Deformation (meteorology) ; Plastics extrusion Polymer Foaming and Composites ; Additive Manufacturing and 3D Printing Technologies ; Polymer crystallization and properties
Authors: Shuo Guo | Hong Tan | Bokai Zhang
Source: Research Square (preprint, 2025-10-14)
Field: Materials Science — Materials Chemistry

Spontaneous phase transition in bacterial polar fluids Polar ; Instability ; Vortex ; Phase (matter) ; Turbulence ; Phase transition ; Concentric ; Ring (chemistry) Material Dynamics and Properties ; Micro and Nano Robotics ; Advanced Thermodynamics and Statistical Mechanics
Authors: Hao Chen | Ulises H. Guzmán | Jesper V. Olsen
Source: bioRxiv (Cold Spring Harbor Laboratory) (preprint, 2025-11-07)
Field: Chemistry — Spectroscopy

High-Throughput Spatial Proteomics at Cellular and Subcellular Resolution via a Hanging Droplet Workflow Abstract Formalin-fixed paraffin-embedded (FFPE) samples are essential for clinical research and spatial proteomics (SP) but are technically challenging to analyze by liquid-chromatography coupled mass-spectrometry (LC-MS) due to losses during protein extraction, evaporation during de crosslinking and low-throughput sample preparation methods. Here, we present a streamlined micro-FFPE proteomics sample preparation protocol for laser-capture micro-dissection (LMD) that enables scalable and high-throughput processing in 96-well format, completing the entire process from tissue lysis to tryptic peptide mixtures on LC-MS-ready Evotips in just 2-hours. Our method integrates whole-slide imaging, LMD, and ultra-sensitive narrow-window data-independent acquisition (nDIA)-MS and facilitates enhanced lysis, de crosslinking, and proteolytic digestion directly within Teflon-based EVO96 chips. By utilizing nano-wells and the hanging droplet concept, our approach significantly reduces surface adsorption, thereby improving processing efficiency for both higher- and very low-input FFPE samples. This enables quantification of &gt;5,500 protein groups (PGs) by nDIA-MS from 50,000 µm² (∼250 cells) with robust performance maintained down to 1000 µm 2 (∼5 cells) with ∼2,500 PGs identified. Application to a panel of breast cancer (BC) tissues precisely discerned BC subtypes and their tumor micro-environment (TME) based on differential MS-based protein abundance of biomarkers including TP53, HER2 and PGR. Individually excised subcellular regions (∼60 µm²) yielded ∼1,500 PGs, demonstrating reliable micro-scale spatial proteomics profiling approaching near-organelle resolution. Teaser Streamlined micro-FFPE protocol enables scalable and high-throughput processing of LMD samples, from lysis to mass spectrometry in 2 hours. Proteomics ; Lysis ; Workflow ; Proteome ; Quantitative proteomics ; Scalability ; Sample preparation ; Label-free quantification ; Mass spectrometry Advanced Proteomics Techniques and Applications ; Mass Spectrometry Techniques and Applications ; Advanced Biosensing Techniques and Applications
Authors: Ahmed Mohamed Abdelrahman | Moataz Ibrahim Badwy | Doaa M. Mohamed | Wafaa Eleraky
Source: Zagazig Veterinary Journal/Zagazig Veterinary Journal (Online) (article, 2025-06-01)
Field: Chemistry — Organic Chemistry

Effect of Solid-State Fermentation on Olive Byproducts on Performance, Beneficial Microorganisms, and Expression of Digestive Tract of Broiler Chickens Interstitial cystitis (IC), also known as bladder pain syndrome (BPS), is a complex, chronic condition that predominantly alters urinary bladder, causing a range of distressing symptoms.It is characterized by irritation or inflammation of bladder lining, leading to recurring episodes of significant pelvic pain and discomfort, along with a heightened urgency and frequency of urination.In severe cases, individuals may experience debilitating pain, which can delay their daily activities and severely impact sleep, work, and personal relationships.Diagnosing and managing IC/BPS remains challenging due to an incomplete understanding of its underlying causes and its tendency to mimic symptoms of other urinary tract disorders, such as overactive bladder or urinary tract infections.Furthermore, the condition can substantially diminish a person's quality of life, as the unpredictable and persistent symptoms can be physically draining and emotionally taxing.Treatment outcomes for IC/BPS vary widely among patients, with many needing a tailored, multimodal approach involving lifestyle changes, medications, physical therapy, and, in some cases, surgical interventions.This overview examines current strategies for diagnosing and managing IC, highlighting the significance of individualized treatment in enhancing patient outcomes. Broiler ; Digestive tract ; Fermentation ; Food science ; Microorganism ; Solid-state fermentation ; Biology ; Biotechnology ; Microbiology ; Chemistry ; Bacteria ; Medicine ; Internal medicine Edible Oils Quality and Analysis ; Moringa oleifera research and applications ; Garlic and Onion Studies
Authors: Ahmed Lasfar | Sanne L. M. van Stratum | Maria Imperatrice | Colin A. J. van Kalkeren | Jean L.J.M. Scheijen | Casper G. Schalkwijk | Danique La Torre | Freddy J. Troost
Source: Frontiers in Nutrition (article, 2025-11-18)
Field: Chemistry — Organic Chemistry

Effects of olive leaf extract supplementation on systemic markers of tissue aging and remodeling in postmenopausal women: a randomized controlled trial with exploratory skin outcomes The study was registered online at ClinicalTrials.gov as NCT05744453 and was conducted at Maastricht University. Randomized controlled trial ; Postmenopausal women ; Olive oil ; Placebo ; Clinical trial ; Skin Aging Edible Oils Quality and Analysis ; Skin Protection and Aging ; Hair Growth and Disorders
Authors: G. Dharmamoorthy
Source: Asian Journal of Pharmaceutics (review, 2025-03-01)
Field: Chemistry — Analytical Chemistry

A Comprehensive Review on Hyphenated Techniques in Pharmaceutical Analysis Hyphenated techniques in pharmaceutical analysis represent a significant advancement in analytical chemistry, combining two or more separation methods with a detection technique to enhance the resolution, sensitivity, and efficiency of analytical processes. This review article discusses various hyphenated techniques employed in pharmaceutical analysis, their principles, applications, advantages, and limitations. Key methods such as high-performance liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, liquid chromatography with nuclear magnetic resonance spectroscopy, and others are examined in detail, showcasing their role in the development, quality control, and regulatory compliance of pharmaceuticals. Computer science Analytical Methods in Pharmaceuticals ; Analytical Chemistry and Chromatography
Authors: Francisco Cammarata-Scalisi | Esteban San Martín | Antonio Cárdenas-Tadich | Maykol Araya-Castillo | Carolina Peralta-Aros | Víctor Olivares | Enrico Bertini | Colin E. Willoughby | Michele Callea
Source: Boletín Médico Del Hospital Infantil de México (English Edition) (article, 2025-09-30)
Field: Materials Science — Polymers and Plastics

COVID-19 infection and intense physical activity in hypokalemic periodic paralysis Background: Hypokalemic periodic paralysis (HPP) is a rare genetic neuromuscular disorder characterized by an autosomal dominant inheritance pattern and a variable clinical phenotype.It is associated with low potassium levels due to defects in muscle ion channels.HPP can be life-threatening, but it can be completely reversed if diagnosed and treated promptly and correctly.Pathogenic variants in a heterozygous in the CACNA1S or SCN4A genes lead to HPP.Clinical case: We present a 16-year-old male with a clinical history of flaccid paralysis associated with hypokalemia following intense physical activity and subsequent COVID-19 infection.During this evaluation, his 12-year-old maternal half-brother exhibited similar symptoms related to intense physical exercise.The affected mother, maternal aunt, and maternal grandfather have variable clinical histories.Genetic testing identified a heterozygous pathogenic variation in the CACNA1S gene (c.2700GA;p.Arg900Ser) in the patient, his mother, and maternal half-brother.Conclusion: The availability of a positive family history facilitates diagnostic guidance and provides insight into the factors triggering crises.Education is the first step in contributing to prevention and management.Furthermore, understanding the etiological cause is crucial for offering available therapeutic options and providing family genetic counseling. Physical activity ; Hypokalemic periodic paralysis ; Paralysis ; Physical exercise ; Myoglobinuria ; Rhabdomyolysis Conducting polymers and applications ; Epilepsy research and treatment ; Ion channel regulation and function
Authors: Bordonaba Iliarte, Marina | Herrera Marteache, Antonio | Conchello Moreno, Pilar
Source: Zaguan (University of Zaragoza Repository) (article, 2025-01-01)
Field: Materials Science — Materials Chemistry

Caracterización y Análisis de Micro y Nanoplásticos en los Alimentos Este trabajo aborda la problemática de los micro y nanoplásticos en la cadena alimentaria, analizando su origen, características, los riegos para la salud humana y los métodos de detección en los alimentos. Estas partículas se consideran contaminantes emergentes derivados de la fragmentación de plásticos más grandes o de su uso intencionado en productos industriales. Su persistencia, tamaño reducido y composición química les permite interactuar con sustancias del entorno y bioacumularse en organismos generando efectos físicos, químicos y biológicos. <br />Se han identificado múltiples vías de contaminación alimentaria, tanto por contaminación de origen ambiental como por el procesado industrial y envasado. Su presencia ha sido documentada en productos alimenticios marinos, sal, agua embotellada, frutas, verduras y miel, lo que evidencia su amplia distribución. Actualmente, se analizan sus posibles efectos potenciales en la salud humana como la inflamación intestinal o toxicidad hepática, así como los riesgos microbiológicos asociados a la plastisfera. <br />El trabajo incluye una revisión exhaustiva de las técnicas analíticas para su detección y cuantificación tales como, la espectroscopía Raman, FTIR, la microscopía electrónica y otras técnicas emergentes como el uso de biosensores, si bien, la falta de protocolos estandarizados limita el estudio comparativo de resultados y la evaluación precisa del riesgo. En la actualidad, los avances tecnológicos como la inteligencia artificial o el uso de dispositivos portátiles ofrecen nuevas oportunidades para la monitorización eficiente en tiempo real de las partículas. No obstante, persisten importantes incertidumbres científicas, tanto en la metodología de identificación como en la valoración del riesgo. <br />Los resultados de este trabajo subrayan la necesidad de seguir investigando para evaluar el riesgo, establecer límites que regulen estos plásticos en alimentos y diseñar estrategias sostenibles de mitigación que garanticen la seguridad alimentaria y prevengan la salud pública.<br /><br /> Human health ; Population ; Chemical products Nanoparticles: synthesis and applications ; Microplastics and Plastic Pollution ; Melamine detection and toxicity
Authors: Majid Shakeri | Hamid Reza Rafieian-Naeini | Hassan Khanaki
Source: Journal of World s Poultry Research (article, 2025-12-25)
Field: Chemistry — Inorganic Chemistry

Impacts of Restricting Ribonucleotide Reductase on Performance, Meat Quality, and Intestinal Health in Broiler Chickens Evaluated by Evans Blue Dye Ribonucleotide reductase (RNR) enzyme is essential for DNA synthesis and overall cellular health. Its inhibition interferes with metabolic pathways and mitochondrial function, leading to increased oxidative damage. Evans blue dye evaluates oxidative damage in tissues by penetrating through ruptured or destabilized membranes, thereby serving as an indicator of cell viability. The present study aimed to investigate the effects of restricting RNR on growth performance, meat quality, and intestinal health in broiler chickens after intestinal development was mainly completed. Twenty male broiler chickens, aged 14 days and weighing 445 ± 5 grams, were randomly divided into two equal groups: a control group and an experimental group, which received an RNR inhibitor (RR) at 20 mg/kg body weight/day for two weeks. Half of the chickens in both groups (5 broiler/group) were injected with Evans blue dye (EB) on the last day of the study. The oxidative damage was measured at the end of the study. The present results indicated that growth performance and feed intake were unchanged during the study. The RNR enzyme increased meat drip loss and lightness while reducing ultimate pH (pHu) compared to the control group. Evans blue concentration increased in the muscle, duodenum, jejunum, and ileum of the experimental group compared to the control group. Although RNR inhibition did not affect growth performance, it led to reduced meat quality and increased oxidative damage. These findings were evidenced by elevated drip loss and increased EB concentration in muscle and in all segments of the small intestine. The present results highlighted the essential role of RNR in maintaining meat quality and tissue integrity of broiler chickens. Keywords: Evans blue dye, Intestine, Meat quality, Ribonucleotide reductase Broiler ; Evans Blue ; Oxidative phosphorylation ; Enzyme ; Ileum ; Enzyme assay ; Oxidative stress ; Cell growth Metal-Catalyzed Oxygenation Mechanisms ; Antioxidant Activity and Oxidative Stress ; Animal Nutrition and Physiology
Authors: Francis Olaolorun | Melanie‐Jayne R. Howes | Taiwo O. Elufioye | Oluwatoyin A. Odeku | James Olukayode Olopade | Paul L. Chazot
Source: Frontiers in Neurology (article, 2025-10-24)
Field: Chemistry — Inorganic Chemistry

Iron chelation as a therapeutic target in vanadium neurotoxicity and Parkinson's disease: role of medicinal plants Bioprospecting plant natural products has yielded significant success in the development of symptomatic treatment of neurodegenerative diseases, including the two most common, Alzheimer's and Parkinson's diseases (PD). Dysregulation of iron has been strongly implicated in the pathophysiology of these serious intractable diseases. A series of Nigerian endemic plants' methanolic extracts were explored using a Ferrozine binding iron chelation assay. This identified <i>Spondias purpurea</i> L. (SP) leaves as a potential therapeutic candidate and this was determined by evaluation of oxidative stress in 6-hydroxydopamine (6-OHDA)-exposed monoamine cell culture and <i>Drosophila</i> models of PD and vanadium neurotoxicity. SP treatment protected CAD cells against 6-OHDA toxicity and improved survival in PINK-1 mutant flies, though it had little effect on motor deficits. Furthermore, SP treatment reduced the vanadium-induced reactive oxygen species, and notably, staggered SP treatment significantly extended lifespan in vanadium-treated flies. Overall, <i>Spondias purpurea</i> L. leaf methanolic extract exhibited iron-chelating, antioxidant, neuroprotective, and life-extending properties, relevant to Parkinson's disease and vanadium-induced toxicity. Oxidative stress ; Neurotoxicity ; Reactive oxygen species ; Medicinal plants ; Chelation therapy ; Toxicity ; Chelation ; Antioxidant ; Cytostasis Vanadium and Halogenation Chemistry ; Trace Elements in Health ; Alzheimer's disease research and treatments
Authors: Rory Samuels | Nimrod Carmon | Bledar Komoni | Jonathan Hobbs | Amy Braverman | Dean M. Young | Joon Jin Song
Source: Environmetrics (article, 2025-07-01)
Field: Chemistry — Analytical Chemistry

Estimation of Impact Ranges for Functional Valued Predictors ABSTRACT Spectroscopy plays a crucial role in various scientific and industrial applications, enabling the analysis of complex materials and their interactions with incident radiation. Hyperspectral remote sensing, also known as imaging spectroscopy, is essential for numerous Earth science applications, spanning multiple disciplines, including ecology, geology, and cryosphere research. With the abundance of current orbital imaging spectrometers, and with space agencies and commercial companies set to expand their use in the next few years, developing methodologies that maximize the utility of these data is crucial. Identifying the wavelength ranges of diagnostic absorption features in spectra is essential for understanding the relationship between spectral data and responses of interest. In this paper, we propose a statistical approach that utilizes Functional Partial Least Squares (FPLS) to model the spectral data as smooth functions and study their impact on the response variable along sub‐intervals of the domain. To capture the localized relationships within specific sub‐intervals, termed impact ranges, we present a novel two‐stage estimation procedure to identify the midpoint and half‐length of the impact ranges. Additionally, we introduce an algorithm for iteratively applying the proposed two‐stage approach to estimate both the number and location of potential impact ranges. The proposed procedure is evaluated via Monte Carlo simulation and is applied to a real dataset of spectra to identify the location of the diagnostic absorption features for predicting calcium carbonate (CaCO 3 ) content in soil. Our methodology accurately estimates the number and location of impact ranges, corresponding to absorption features in spectral data. Estimation ; Econometrics ; Statistics ; Mathematics ; Economics Spectroscopy and Chemometric Analyses ; Advanced Statistical Methods and Models