Authors: Xavier Pillet
Source: Zenodo (CERN European Organization for Nuclear Research) (article, 2026-01-01)
Field: Chemistry — Organic Chemistry

Rapport stratégique : Ir@C60 en médecine régénérative et longévité Résumé FRCe document, produit avec l’assistance de ChatGPT 5.2 Thinking et Gemini 3 Raisonnement, est publié sous licence Apache 2.0. Il constitue une publication défensive (antériorité) et entre dans l’état de la technique au sens des législations applicables (EPC Art. 54(2); French IPC Art. L 611-11; cf. 35 U.S.C. §102(a)). Il divulgue, de manière “enabling”, un portefeuille d’innovations autour de l’endofullérène Ir@C60 : synthèse (arc DC/arc pulsé, ablation laser, confinement magnétique, mélanges de gaz), purification haut débit (HPLC parallèle, SFC→HPLC, CCC/CPC, pré-enrichissement par gradient, membranes), QA/QC (TEM/EDX, UV-Vis-NIR, ICP-MS Ir libre, intégrité de cage), formulations (IV liposomes, micelles, lyophilisats, oral huile/nanoémulsion, patchs/microneedles/implants), imagerie CT (phantoms, DECT/spectral, reconstruction IA), capteurs redox, sécurité EHS, et plateformes data (FHIR, fédéré). Abstract ENThis document, produced with the assistance of ChatGPT 5.2 Thinking and Gemini 3 Raisonnement, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) entering the prior art upon release under (art. L 611-11 CPI / art. 54(2) CBE), and more broadly under the applicable patent statutes (including 35 U.S.C. §102(a)). It discloses enabling, reproducible innovations centered on the Ir@C60 endohedral metallofullerene: synthesis routes (DC/pulsed arc, laser ablation, magnetic plasma shaping, inert-gas recipes), high-throughput purification (parallel HPLC, SFC-to-HPLC, CCC/CPC, density-gradient enrichment, membrane polishing), QA/QC and safety (TEM/EDX proof, UV-Vis-NIR fingerprints, free-iridium ICP-MS, cage integrity stress tests), formulations and delivery (IV PEGylated liposomes, polymeric micelles, lyophilized injectables, oral oils/nanoemulsions, transdermal patches/microneedles/implants), quantitative CT imaging (phantoms, dual-energy/spectral workflows, AI reconstruction), bioelectronic redox sensing, EHS engineering, and interoperable/federated data platforms. Timestamp: 2026-01-01T15:34:03ZSHA-256: 7195cb0a534c9b3234d9022a624dfc7998d7dc6e9e98a2dfed968b1fe5337615 Liste des innovations & classification (IPC ; CPC)1. Optimized Ir@C60 arc reactor — IPC C01B 32/00 ; CPC C01B 32/1682. Laser-ablation Ir seeding — IPC C01B 32/00 ; CPC C01B 32/1683. Auto-feed traveling anode — IPC H05B 7/00 ; CPC H05B 7/1484. Closed-loop helium recycling — IPC F17C 1/00 ; CPC F17C 1/105. Centrifuge pre-enrichment pre-HPLC — IPC B01D 21/00 ; CPC B01D 21/0086. Parallel multi-column HPLC rack — IPC B01D 15/08 ; CPC B01D 15/0837. ML chromatogram peak classifier — IPC G06F 18/20 ; CPC G06F 18/232138. Inline MS yield closed-loop — IPC G01N 27/62 ; CPC G01N 27/6229. Ir@C60 reference QC kit — IPC G01N 30/02 ; CPC G01N 30/7210. Free-iridium ICP-MS release test — IPC G01N 21/78 ; CPC G01N 21/78211. IV PEGylated liposome Ir@C60 — IPC A61K 9/127 ; CPC A61K 9/12712. Oral MCT oil Ir@C60 — IPC A61K 9/48 ; CPC A61K 9/480813. Synergistic antioxidant co-formulation — IPC A61K 31/202 ; CPC A61K 31/20214. Ir@C60 hydrogel wound dressing — IPC A61L 15/44 ; CPC A61L 15/44715. Anti-inflammatory implant coating — IPC A61L 27/06 ; CPC A61L 27/0616. 3D printed regenerative scaffold — IPC A61L 27/38 ; CPC A61L 27/3817. Ir@C60 bioelectronic redox probe — IPC G01N 27/327 ; CPC G01N 27/327618. Ir@C60 CT contrast agent — IPC A61K 49/04 ; CPC A61K 49/04319. Low-dose CT AI reconstruction — IPC G06T 5/50 ; CPC G06T 5/50120. Programmed radioprotection dosing — IPC A61P 39/06 ; CPC A61P 39/0621. Wearable ROS closed-loop dosing — IPC A61B 5/00 ; CPC G16H 40/6322. Cloud LIMS + eCRF platform — IPC G16H 10/60 ; CPC G16H 10/6023. Federated long-term safety learning — IPC G06N 20/00 ; CPC G06F 21/6224. Standard nano-endo toxicology package — IPC A61B 5/145 ; CPC G01N 33/48725. Workshop nanoparticle air monitor — IPC G01N 21/25 ; CPC G01N 21/25126. Oxygen-barrier capsule packaging — IPC B65D 81/32 ; CPC B65D 81/3227. Clean iridium provenance ledger — IPC G06Q 10/08 ; CPC G06Q 10/08328. Hydrophilization for renal clearance — IPC A61K 31/722 ; CPC A61K 31/72229. Exosome delivery of Ir@C60 — IPC A61K 47/69 ; CPC A61K 47/6930. GMP microfluidic formulation chip — IPC B01L 3/00 ; CPC B01L 3/50231. Standardized TEM Z-contrast proof — IPC G01N 23/00 ; CPC G01N 23/20332. UV-Vis-NIR Ir@C60 fingerprint — IPC G01N 21/35 ; CPC G01N 21/350433. Recycled “green” solvent skid — IPC B01D 3/00 ; CPC B01D 3/1434. Ir recovery from insoluble residues — IPC C22B 3/04 ; CPC C22B 11/0035. CO interlocked arc safety module — IPC G08B 21/00 ; CPC G08B 21/1836. Helium leak mapping by mass-spec — IPC G01M 3/00 ; CPC G01M 3/2637. Post-HPLC selective crystallization — IPC B01D 9/00 ; CPC B01D 9/0238. CT phantom calibration for Ir@C60 — IPC A61B 6/03 ; CPC A61B 6/0339. Adaptive CT contrast-to-dose control — IPC A61B 6/00 ; CPC A61B 6/0340. Liposome cold-chain traceability — IPC B65D 81/18 ; CPC B65D 81/1841. Micro-dose administration dispenser — IPC A61J 7/00 ; CPC A61J 7/0242. Longevity ePRO guided workflow — IPC G16H 20/70 ; CPC G16H 20/7043. Mitochondrial biomarker assay panel — IPC C12Q 1/00 ; CPC C12Q 1/68644. Bioaccumulation stopping-rule protocol — IPC A61B 5/145 ; CPC G16H 40/6745. Cleavable prodrug clearance design — IPC A61K 31/722 ; CPC A61K 31/72246. Endo-selective HPLC column method — IPC B01D 15/08 ; CPC B01D 15/08347. Standard soot extraction pre-analytics — IPC B01D 11/04 ; CPC B01D 11/0448. Vacuum drying anti-aggregation — IPC B01D 1/00 ; CPC B01D 1/0049. Neural microelectrode Ir@C60 coating — IPC A61N 1/05 ; CPC A61N 1/0550. Lipophilic transdermal matrix patch — IPC A61K 9/70 ; CPC A61K 9/700751. Salivary ROS point-of-care strip — IPC G01N 33/487 ; CPC G01N 33/48752. Cage integrity accelerated stress test — IPC G01N 33/50 ; CPC G01N 33/5053. Traceable GMP micro-batch workflow — IPC G06Q 10/06 ; CPC G06Q 10/063954. Parasitic metal nanoparticle detector — IPC G01N 33/487 ; CPC G01N 33/48755. Personalized Ir@C60 PK/PD model — IPC G16H 50/20 ; CPC G16H 50/2056. Federated post-market surveillance — IPC G16H 10/60 ; CPC G06F 21/6257. Photo-stable microencapsulation — IPC A61K 9/51 ; CPC A61K 9/510758. Dermal exposure dosimeter patch — IPC G01N 21/25 ; CPC G01N 21/25159. FHIR profile for nano-drugs — IPC G16H 10/60 ; CPC G16H 10/6060. Yield-to-market techno-econ model — IPC G06Q 50/00 ; CPC G06Q 50/26361. Pulsed-arc anti-dissociation recipe — IPC C01B 32/00 ; CPC C01B 32/16862. Magnetic plasma confinement coils — IPC H05H 1/24 ; CPC H05H 1/2463. Optimized He/Ne gas mixture — IPC C01B 32/00 ; CPC C01B 32/16864. Multi-zone cold soot collector — IPC B01D 46/00 ; CPC B01D 46/3065. Inline plasma OES PAT control — IPC G01N 21/63 ; CPC G01N 21/63766. Raman/FTIR extraction QC gate — IPC G01N 21/65 ; CPC G01N 21/65867. Hybrid SFC-to-HPLC purification — IPC B01D 15/08 ; CPC B01D 15/08368. Countercurrent chromatography for endo — IPC B01D 15/08 ; CPC B01D 15/08369. Membrane filtration colloid polishing — IPC B01D 61/00 ; CPC B01D 61/1470. Organic-solvent electrophoretic separation — IPC G01N 27/447 ; CPC G01N 27/447771. Inline DLS release for liposomes — IPC G01N 21/53 ; CPC G01N 21/53572. Nanomaterial endotoxin SOP — IPC G01N 33/569 ; CPC G01N 33/56973. Non-degrading sterilization selection — IPC A61L 2/00 ; CPC A61L 2/2674. Lyophilized reconstitutable IV form — IPC A61K 9/19 ; CPC A61K 9/190475. Stable oral nanoemulsion — IPC A61K 9/107 ; CPC A61K 9/107576. Polymeric micelles Ir@C60 — IPC A61K 9/51 ; CPC A61K 9/511577. Microneedle transdermal delivery — IPC A61K 9/70 ; CPC A61K 9/708478. Implantable microdose pump — IPC A61M 5/142 ; CPC A61M 5/1424479. Minimal mitochondrial targeting addend — IPC A61K 31/722 ; CPC A61K 31/72280. Isolated mitochondria ROS assay — IPC C12Q 1/00 ; CPC C12Q 1/68681. High-content ROS imaging assay — IPC G01N 33/487 ; CPC G01N 33/48782. Dual-energy CT quantification protocol — IPC A61B 6/03 ; CPC A61B 6/0383. Spectral CT k-edge workflow — IPC A61B 6/03 ; CPC A61B 6/0384. Ex vivo tissue XRF mapping — IPC G01N 23/00 ; CPC G01N 23/20785. Washout scheduling optimization — IPC A61P 39/06 ; CPC A61P 39/0686. Antioxidant interaction guardrails — IPC A61K 31/202 ; CPC A61K 31/20287. QR + spectral anti-counterfeit — IPC G06Q 20/40 ; CPC G06Q 20/4088. Immutable QC data watermarking — IPC G06F 21/64 ; CPC G06F 21/64289. Endo-fullerene data ontology — IPC G16H 10/60 ; CPC G16H 10/6090. Secure edge inference on wearable — IPC G06F 21/52 ; CPC G06F 21/5691. QC calibration-as-a-service platform — IPC G06Q 10/06 ; CPC G06Q 10/063992. Energy-normalized yield KPI — IPC G06Q 50/06 ; CPC G06Q 50/26393. Arc-process digital twin — IPC G06F 30/20 ; CPC G06F 30/2094. Isotopic mass-balance PK tracing — IPC G01N 33/50 ; CPC G01N 33/5095. Safe D2C nutraceutical logistics — IPC G06Q 10/08 ; CPC G06Q 10/08396. Nano solvent waste treatment SOP — IPC B09B 3/00 ; CPC B09B 3/6097. Nanodrug hemocompatibility panel — IPC G01N 33/53 ; CPC G01N 33/5398. “Ir-free” leaching proof standard — IPC G01N 21/78 ; CPC G01N 21/78299. Product photoprotection protocol — IPC B65D 81/26 ; CPC B65D 81/26100. Emerging-market frugal deployment — IPC G06Q 50/06 ; CPC G06Q 50/263 KeywordsIr@C60, endohedral metallofullerene, iridium encapsulation, arc-discharge synthesis, laser ablation, HPLC purification, density-gradient centrifugation, mitochondrial ROS scavenging, liposome formulation, nutraceutical longevity, CT contrast agent, AI imaging reconstruction, bioelectronic redox sensor, closed-loop dosing, federated safety analytics, nanotoxicology, GMP microfluidics, supply-chain provenance, packaging shelf-life Statute ; Ablation ; Transdermal ; Data Protection Act 1998 Fullerene Chemistry and Applications ; Laser-Ablation Synthesis of Nanoparticles ; Graphene and Nanomaterials Applications