jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Nathan K. Bentley | Johan Liotier | Hanyan Lyu | Theresa Peters | Thomas Brandstetter | Jürgen Rühe
Source: Scientific Reports (article, 2026-01-14)
Field: Materials Science — Biomaterials

Heat and solvent resistant electrospun nanofibers for tunable fluid transport in lateral flow applications Lateral flow devices (LFDs) rely on porous materials to guide liquid transport, and electrospun fiber mats have emerged as attractive candidates due to their high surface area, tunable porosity, and ease of functionalization. However, conventional electrospun nanofibers often deform or dissolve when exposed to heat or to solvents commonly used in biochemical assays, limiting their applicability. To address this challenge, we developed electrospun poly(methyl methacrylate) (PMMA) nanofibers that are both heat-stable and solvent-resistant through the incorporation of photoreactive groups and subsequent solid-state crosslinking via the C, H-insertion crosslinking (CHic) reaction. PMMA fibers containing methacryloyloxy benzophenone (MABP) units were rapidly activated with UV light, yielding nanofiber mats that retain their morphology under elevated temperatures and also in solvents typically used in biochemical assays. Beyond mechanical and chemical stability, we demonstrate that the surface energy of these fibers can be precisely tuned through the formation of a crosslinked hydrogel sheath composed of dimethyl acrylamide (DMAA) and MABP comonomers. This sheath can be applied either by dip-coating of mats of pre-formed fibers or by coaxial electrospinning, and becomes covalently integrated with the fiber core upon light activation. The resulting core-sheath structure transforms the originally hydrophobic PMMA mat into a highly hydrophilic, paper-like material capable of supporting controlled capillary flow. These robust and tunable nanofiber mats offer new opportunities for the design of lateral flow devices with improved solvent compatibility, thermal stability, and flow performance. Nanofiber ; Porosity ; Electrospinning ; Capillary action ; Polymer ; Fiber ; Solvent ; Covalent bond Electrospun Nanofibers in Biomedical Applications ; Innovative Microfluidic and Catalytic Techniques Innovation ; Microfluidic and Capillary Electrophoresis Applications
Authors: Abirami SENTHIL | Sylvia H. Larsson | Sara Wallstén | Λεωνίδας Μάτσακας | Paul Christakopoulos | Ulrika Rova | Io Antonopoulou
Source: Cellulose (article, 2026-02-12)
Field: Materials Science — Biomaterials

Cellulose foams from organosolv pulps with potential application as active packaging Abstract This study demonstrates a green method to produce low-density cellulose using organosolv pretreated pulp, which also yields high-purity fractions of hemicelluloses and lignin that can be processed further to obtain different chemicals. A base-catalyzed organosolv pretreatment was employed on Norway spruce woodchips to release the cellulose fibrils, which were used to make low-density (20 kg/m 3 ) porous foams (98%). Sodium hydroxide was used as a catalyst, ranging from 0.25 to 1.5 M. The fibers obtained from these pretreatment conditions were characterized and correlated to the foam formation and properties. Furthermore, the samples were compared to foams made from commercially available unbleached and bleached sulfite pulp. A simple production technique was employed by rapidly agitating cellulose pulp with surfactant and additives to induce air into the system. The cellulose fibers arranged around the bubbles and formed a 3-D network upon drying. The lignin content and fiber aspect ratio of the organosolv fibers showed a positive correlation to the foam formation and stability. The foams presented good mechanical resistance (75%), and this property was tuned by the additives. High moisture adsorption tendency and comparably slower scavenging of antioxidant molecules were hypothesized to be due to the position of lignin in the interiors of the cell wall; these properties make the organosolv foams interesting for bioactive packaging applications. Organosolv ; Cellulose ; Lignin ; Pulp (tooth) ; Fiber ; Nanofiber ; Sodium hydroxide ; Porosity Advanced Cellulose Research Studies ; Lignin and Wood Chemistry ; Nanocomposite Films for Food Packaging
Authors: Haia Kharraz | Pere Alemany | Enric Canadell | Yann Le Gal | Thierry Roisnel | Marc Fourmigué | Dominique Lorcy
Source: Dyes and Pigments (article, 2026-03-04)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Tunable NIR absorption in gold complexes with mixed dithiolene/diselenolene ligands Based on a step-by-step procedure, an extensive series of monoanionic d 8 gold complexes has been developed by replacing in mixed-ligand bis(dithiolene) complexes the coordinating sulfur atoms by selenium ones, either on one ligand or on both, leading to very original and stable mixed-ligand gold (dithiolene)(diselenolene) and bis(diselenolene) complexes. The neutral radical species obtained upon 1e – oxidation of bis(dithiolene) gold complexes are known to exhibit an NIR absorption band in the 1180−2070 nm range, of interest in telecommunications, biological imaging and solar cells. Here, spectroelectrochemical investigations demonstrate that the NIR signature of mixed-ligand bis(dithiolene), (dithiolene)(diselenolene) and bis(diselenolene) gold complexes associating two different dithiolene or diselenolene ligands is found at higher energy, out of the range of the homoleptic analogs. Moreover, introduction of Se atoms on the more electron-rich ligand modifies significantly the LUMO of the complex, leading to a further 200 nm bathochromic shift of this characteristic NIR absorption, thus offering an additional control of the NIR absorption of these neutral radical gold complexes. The preparation of mixed ligand gold complexes, dithiolene and diselenolene, enables extra control over NIR absorption. • Performance of the strategy for the synthesis of gold dithiolene/diselenolene complexes • Gold mixed ligands complexes as NIR absorbers • Electron-rich and electron-poor ligands enable control of absorption in the near infrared. • Additional control of NIR absorption through the introduction of a diselenolene ligand Bathochromic shift ; Homoleptic ; Ligand (biochemistry) ; Absorption (acoustics) ; Gold Compounds ; Absorption spectroscopy Organic and Molecular Conductors Research ; Magnetism in coordination complexes ; Organic Electronics and Photovoltaics
Authors: AMIT SURVE | S. K. Patil
Source: ChemistrySelect (article, 2026-02-01)
Field: Materials Science — Materials Chemistry

Compositional Modulation of Zn <sub>1‐x</sub> (Cu <sub>0.5</sub> Ni <sub>0.5</sub> ) <sub>x</sub> Fe <sub>2</sub> O <sub>4</sub> Ferrite Nanoparticles: A Co‐Precipitation Route to Tunable Magnetic Properties ABSTRACT This research examines the creation of zinc ferrite (ZnFe 2 O 4 ) along with various Cu‐Ni co‐doped ferrites that have different amounts of zinc, utilizing the co‐precipitation technique. The formulations studied consist of Zn 0 . 75 Cu 0 . 125 Ni 0 . 125 Fe 2 O 4 , Zn 0 . 5 Cu 0 . 25 Ni 0 . 25 Fe 2 O 4 , Zn 0 . 25 Cu 0 . 375 Ni 0 . 375 Fe 2 O 4 , and Cu 0 . 5 Ni 0 . 5 Fe 2 O 4 . XRD, SEM, FTIR, and VSM were employed to analyze structural, morphological, and magnetic characteristics. Findings indicate that an increase in Cu─Ni doping improves the magnetic properties and alters particle shape, thus providing adjustable characteristics for usage in magnetic technologies and microwave absorption systems. Structural, morphological, and magnetic properties were investigated using XRD, SEM, FTIR, and VSM. Ferrite (magnet) ; Microwave ; Zinc ; Doping ; Analytical Chemistry (journal) ; Zinc ferrite ; Copper ; Modulation (music) Magnetic Properties and Synthesis of Ferrites ; Electromagnetic wave absorption materials ; Metallic Glasses and Amorphous Alloys
Authors: Jinan Alhuwayshil | Nouf Alnajim | Sarah bin Dulaym | Jehan Barakat Alamre | Arwa Alsubait | Afrah E. Mohammed | Sahar S. Alghamdi
Source: Biomolecules & Therapeutics (article, 2026-02-27)
Field: Chemistry — Organic Chemistry

Quinoxaline Derivatives in Cancer Therapy: Insights into Mechanisms of Action and Therapeutic Applications Cancer continues to be a leading cause of morbidity and mortality globally, which necessitates the development of more effective and less toxic therapies. Quinoxaline derivatives, a class of heterocyclic compounds with versatile chemical structures, have emerged as promising candidates for anticancer drug development. These derivatives exhibit a range of biological activities and have shown significant efficacy against various tumors. However, the therapeutic potential of quinoxaline derivatives, particularly in clinical applications, remains underexplored, highlighting the need for further research to optimize their use as anticancer agents. This systematic review aims to provide an updated analysis of quinoxaline derivatives' anticancer potential, focusing on their mechanisms of action and therapeutic applications in oncology. Following PRISMA guidelines, a thorough search was conducted in MEDLINE/PubMed and Science Direct for studies from 2020 to 2024. Relevant keywords were used to identify studies on quinoxaline derivatives and their anticancer properties, resulting in the selection of 77 studies based on pharmacological activity and mechanisms. The review included 77 studies exploring various anticancer activities of quinoxaline derivatives. Key findings indicate that these compounds effectively inhibit cancer cell growth through multiple mechanisms, including the inhibition of topoisomerases, kinases, and other critical proteins involved in cancer progression. Additionally, they demonstrate strong antiproliferative and pro-apoptotic effects across several cancer cell lines, highlighting their broad therapeutic potential. Quinoxaline derivatives represent a promising class of compounds in anticancer therapy due to their diverse biological activities and multiple molecular targets. The development of these derivatives as targeted therapies holds the potential for more effective cancer treatments. Quinoxaline ; Cancer ; Drug ; Anticancer drug ; Drug discovery ; Cancer therapy ; Cancer treatment Synthesis and Biological Evaluation ; Synthesis and Reactions of Organic Compounds ; Chemical synthesis and pharmacological studies
Authors: Nestor Bracho Pozsoni | Fatima A Bouye | Tom Planckaert | Valentina Gandin | Thomas Scattolin | Steven P Nolan | Chiara Donati | Kristof Van Hecke
Source: Dalton Transactions (article, 2026-01-01)
Field: Chemistry — Organic Chemistry

Gold( <scp>i</scp> )–indomethacin anticancer candidates with anti-breast cancer stem cell properties The rational design, sustainable synthesis, and comprehensive biological evaluation of a new family of gold(I)-indomethacin complexes bearing N-heterocyclic carbene (NHC) ligands are reported. The mild, scalable synthetic protocol affords the first reported examples of well-defined [Au(NHC)(indomethacin)] complexes that display robust chemical and thermal stability and exhibit potent antiproliferative activity across a panel of human cancer cell lines, frequently outperforming cisplatin, including in cisplatin-resistant models. Notably, these gold(I)-indomethacin derivatives retain strong cytotoxicity against breast cancer stem cells (CSCs)-like populations and demonstrate superior efficacy in physiologically relevant 3D spheroid models. Mechanistic investigations reveal that their anticancer activity correlates with efficient inhibition of thioredoxin reductase, disruption of intracellular thiol homeostasis, and induction of oxidative stress through reactive oxygen species generation. Rational design ; Cancer ; Cancer stem cell ; Stem cell ; Cell culture ; Cancer cell lines ; Carbene N-Heterocyclic Carbenes in Organic and Inorganic Chemistry ; Metal complexes synthesis and properties ; Click Chemistry and Applications
Authors: Daniel Knyszek | Margarita Shishkova | Leif Kelling | Henning Steinert | Viktoria H. Gessner
Source: ChemRxiv (article, 2026-02-15)
Field: Chemistry — Inorganic Chemistry

A Crystalline Ylide-Stabilized Stibenium Cation We report the isolation of the first stibenium cation stabilized by two thiophosphinoyl-tethered ylide substituents. The cation is directly accessible via salt metathesis between the metalated ylide with antimony trichloride. Despite the typically strong electron-donating character of ylide substituents, crystal structure analysis in combination with detailed computational studies reveal the presence of C-Sb single bonds, with the lone pairs remaining localized at the ylidic carbon centers. Instead, stabilization of the stibenium cation arises from the thiophosphinoyl groups, which provide both steric protection and additional S-Sb interactions. In contrast, a sulfonyl-functionalized ylide fails to sufficiently stabilize an analogous stibenium cation, highlighting the decisive influence of ylide substituent design on the stabilization of highly reactive main-group cations. Ylide ; Substituent ; Steric effects ; Lone pair ; Antimony ; Crystal structure ; Pnictogen Synthesis and characterization of novel inorganic/organometallic compounds ; Synthetic Organic Chemistry Methods ; Organometallic Complex Synthesis and Catalysis
Authors: Nasrin Saberi Harooni | Mohammad Reza Naimi-Jamal | Mohammad G. Dekamin | Azar Tahghighi
Source: Scientific Reports (article, 2026-02-19)
Field: Chemistry — Organic Chemistry

Assessment of antimicrobial activity of [1,2,4]triazolo[4, 3-a]quinoxaline derivatives individually and in combination with levofloxacin The need to develop new and effective antimicrobial compounds has become a fundamental requirement of the therapeutic system worldwide. In this study, a series of synthetic 4-amino triazoloquinoxaline derivatives were designed and synthesized. The chemical structure of these compounds was confirmed using spectroscopic methods (1H-NMR, 13C-NMR, FT-IR, and MS). Their antimicrobial activity against several Gram-positive and Gram-negative bacteria was then evaluated. The results of biological experiments showed that the synthetic compounds 5b, 5d, and 5h derivatives have moderate antimicrobial activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans compared to some standard drugs. Non-toxic compounds were selected based on MTT and hemolysis assays, and their synergistic effect in combination with levofloxacin (LEV) was investigated. The findings confirmed the effectiveness of combination therapy in reducing the dose of LEV, compounds 5d and 5h against S. aureus and S. epidermidis, as well as 5d and 5b against resistant isolates of MRSA and P. aeruginosa, respectively, with a fractional inhibitory concentration index ≤ 0.5. Field-emission scanning electron microscopy confirmed the complete damage of S. aureus, S. epidermidis, and P. aeruginosa following exposure to the combination therapy of compounds 5b, 5d, and 5h with LEV. This new synergistic therapy has the potential to be used as a novel approach of treating infectious diseases after future investigations. Antimicrobial ; Staphylococcus aureus ; Levofloxacin ; Hemolysis ; Pseudomonas aeruginosa ; Candida albicans ; Minimum inhibitory concentration ; Escherichia coli Synthesis and Biological Evaluation ; Synthesis and biological activity ; Quinazolinone synthesis and applications
Authors: Jem Pitcairn | Mario Antonio T. Ongkiko | Peter J. Speakman | Jeremiah P. Tidey | Jack W. Jordan | Graham N. Newton | J Ross Stewart | Pascal Manuel | Andrew J. Morris | Matthew J. Cliffe
Source: ChemRxiv (article, 2026-02-25)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Enhancing superexchange through frontier orbital engineering in a van der Waals metal-organic magnet Van der Waals metal-organic magnets (vdW MOMs) offer the possibility of realising a wide range of magnetic functionalities not possible in inorganic vdW magnets. In particular, their modularity allows for specific control over ligand-mediated superex- change and hence their ground states. We report a new vdW MOM, CrCl2(btd) (btd = 2,1,3-benzothiadiazole), assembled from a high-energy early transition metal and a redox-active ligand, which leads to a small charge-transfer gap. We solve the structure using a combination of powder neutron diffraction and single crystal electron diffrac- tion, showing that this material contains Cr2+btd0. Magnetometry, neutron diffraction and inelastic neutron scattering measurements allow us to quantitatively determine the magnetic properties of this vdW magnet, showing it is a collinear rectangular antifer- romagnet with small easy-axis anisotropy (JCl = −15.31(5) K, Jbtd = −6.96(10) K, D = −2.0(2) K). Critically, we find that the superexchange through btd, with a low lying LUMO, is significantly stronger than in the CrCl2(pym) (pym = pyrimidine) analogue (Jpym = 1.2(2) K), demonstrating that exchange can be enhanced by potentially redox-active ligands without actual electron-transfer onto ligands. This work provides a route towards vdW antiferromagnetic MOMs with strong magnetic superexchange. Superexchange ; van der Waals force ; Neutron diffraction ; Antiferromagnetism ; Magnet ; Inelastic neutron scattering ; Neutron scattering Magnetism in coordination complexes ; Organic and Molecular Conductors Research ; Chemical and Physical Properties of Materials
Authors: Nikolaos Politakos | Apostolos Avgeropoulos
Source: Polymers (article, 2026-01-27)
Field: Materials Science — Materials Chemistry

Advances and Applications of Block Copolymers II Polymers are an essential class of materials; they are constantly evolving, and new monomers/polymers are being synthesized and/or produced every day [...]. Copolymer ; Polymer ; Block (permutation group theory) ; Class (philosophy) Block Copolymer Self-Assembly ; Advanced Polymer Synthesis and Characterization ; Synthesis and Properties of Aromatic Compounds
Authors: Pierre Delliere | Vickie Caetano-Maria | Florian Cuminet | Karim Aissou | Christine Joly-Duhamel | Camille Bakkali-Hassani | Sylvain Caillol
Source: Polymer (article, 2026-03-31)
Field: Materials Science — Polymers and Plastics

Bio-based amines from urethane oligomer for tunable epoxy thermosets The scarcity of bio-based amines, particularly ones with more than two primary amines, limits the development of sustainable thermosets. Herein, novel bio-based hardeners structures were synthesized from widely available building blocks, including a pentanediisocyanate isocyanurate trimer ( t PDI or STA-NCO) and urethane prepolymers prepared from polypropanediol (PPD, 500–2,000 g·mol -1 ). A controlled hydrolysis process allowed the obtention of four amines: STA-NH 2 ( = 3) and PPD-based amines V500-NH 2 , V1000-NH 2 , and V2000-NH 2 ( = 4), with biobased carbon content above 83 %. Their structures were confirmed by NMR and FTIR, and Amine Hydrogen Equivalent Weights (AHEW) were determined by 19 F NMR titration after derivatization. Curing behavior with vanillin-based epoxy (DGEVA) was investigated by FTIR and gel time measurements. Reactivity depended on amine functionality, viscosity, and AHEW, with gelation times as low as 12 min at 50 °C. STA-NH 2 produced rigid networks with high stress at break (55 MPa), while PPD-based amines introduced soft segments and phase segregation, yielding ductile materials with Young’s modulus down to 4.0 MPa and elongation up to 114%. A dual hardener strategy combining STA-NH 2 and V2000-NH 2 enabled continuous tuning of thermomechanical and tensile properties. Soft segments dominated below 20 wt.% STA-NH 2 , whereas hard segments dictated properties above this threshold. This study demonstrates a versatile approach for designing bio-based amines, providing tunable epoxy thermosets with adjustable rigidity, ductility, and thermal performance. The approach paves the road to create biobased materials with tailored properties for various applications. • Biobased amines with high functionality were synthetized • Amines were employed as hardener for vanillin derived epoxy • Poly(propane diol) soft segment allowed tunable properties • Amine synthesis methodology paves the way to specific functional materials Thermosetting polymer ; Epoxy ; Oligomer ; Curing (chemistry) ; Trimer ; Dynamic mechanical analysis ; Ultimate tensile strength ; Fourier transform infrared spectroscopy ; Amine gas treating ; Prepolymer Polymer composites and self-healing ; Carbon dioxide utilization in catalysis ; Epoxy Resin Curing Processes
Authors: Mohammad Nawshad | Riyamol Kallikkoden Razack | Muni Raj Maurya | Umar Amjad | Hajera Shafaf | Numy Eranikkal | Anwarul Hasan | Kishor Kumar Sadasivuni
Source: Aerosol Science and Engineering (article, 2026-03-26)
Field: Materials Science — Materials Chemistry

Turn-On Fluorescent Sensing of Dust Particles Using Optimized Microwave-Synthesized Carbon Quantum Dots A significant contributor to particulate matter (PM), dust particles negatively affect air quality and pose serious health risks, such as cardiovascular and respiratory issues. Therefore, it is crucial to accurately and efficiently detect dust particles to monitor air pollution and reduce its harmful effects. This research involved synthesising carbon quantum dots (CQDs) from citric acid and urea using microwave-assisted irradiation, with systematic adjustments of precursor ratios and reaction times to increase fluorescence. The CQDs emitted a distinct blue glow, achieved with a 1:2 urea-citric acid mixture and a microwave treatment lasting 2 min, which produced the highest fluorescence levels. When evaluated as fluorescent probes for particulate matter detection, using quartz sand as a model substrate, the CQDs showed a concentration-dependent decrease in fluorescence intensity, with a detection limit (LOD) of 0.31 mg/ml within the concentration range of 0.1–1 mg/ml. Although the method demonstrates potential, its current detection threshold is above typical ambient particulate matter concentrations, and the use of quartz sand limits direct applicability to chemically diverse real-world aerosols. These findings highlight the promise of CQDs for air quality monitoring and suggest avenues for improving sensitivity and expanding applicability to actual particulate matter sources. Particulates ; Detection limit ; Fluorescence ; Quartz ; Carbon fibers ; Quantum dot ; Citric acid ; Air pollution Carbon and Quantum Dots Applications ; Atmospheric chemistry and aerosols ; Atmospheric aerosols and clouds