jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Katsuhiko Ariga
Source: Molecules (review, 2024-07-03)
Field: Chemistry — Electrochemistry

Liquid–Liquid and Liquid–Solid Interfacial Nanoarchitectonics Nanoscale science is becoming increasingly important and prominent, and further development will necessitate integration with other material chemistries. In other words, it involves the construction of a methodology to build up materials based on nanoscale knowledge. This is also the beginning of the concept of post-nanotechnology. This role belongs to nanoarchitectonics, which has been rapidly developing in recent years. However, the scope of application of nanoarchitectonics is wide, and it is somewhat difficult to compile everything. Therefore, this review article will introduce the concepts of liquid and interface, which are the keywords for the organization of functional material systems in biological systems. The target interfaces are liquid-liquid interface, liquid-solid interface, and so on. Recent examples are summarized under the categories of molecular assembly, metal-organic framework and covalent organic framework, and living cell. In addition, the latest research on the liquid interfacial nanoarchitectonics of organic semiconductor film is also discussed. The final conclusive section summarizes these features and discusses the necessary components for the development of liquid interfacial nanoarchitectonics. Liquid liquid ; Materials science ; Chromatography ; Chemistry Electrochemical Analysis and Applications ; Surface Chemistry and Catalysis ; Spectroscopy and Quantum Chemical Studies
Authors: Alfonsina D’Amato | Domenico Iacopetta | Jessica Ceramella | Raffaele Troiano | Annaluisa Mariconda | Alessia Catalano | M. Marra | Carmela Saturnino | Camillo Rosano | Maria Stefania Sinicropi | Pasquale Longo
Source: European Journal of Medicinal Chemistry (article, 2024-08-09)
Field: Chemistry — Organic Chemistry

Design, synthesis and biological evaluation of multitarget hybrid molecules containing NHC-Au(I) complexes and carbazole moieties Chemistry ; Carbazole ; Combinatorial chemistry ; Rational design ; Molecule ; Biological activity ; Small molecule ; Stereochemistry ; Topoisomerase ; DNA ; In vitro ; Nanotechnology ; Biochemistry ; Organic chemistry N-Heterocyclic Carbenes in Organic and Inorganic Chemistry ; Synthetic Organic Chemistry Methods ; Quinazolinone synthesis and applications
Authors: Musbahu Adam Ahmad | Sri Sumarsih | Jia‐Yaw Chang | Mochamad Zakki Fahmi
Source: ACS Omega (article, 2024-05-02)
Field: Materials Science — Materials Chemistry

Mass Spectrometry-Based Analyses of Carbon Nanodots: Structural Elucidation Carbon nanodots (CNDs) are nanomaterials with ubiquitous applications in health for diagnosis and treatments. The key to enhancing the applications of carbon nanodots in various fields lies on how deep its structure is understood. Here, we review the mass spectroscopy (MS) techniques employed for carbon nanodot analysis. We aimed to revive the use of MS to support the structural elucidation of carbon nanodots. General techniques used in nanomaterials characterization include laser desorption/ionization (LDI), matrix-assisted LDI (MALDI), inductively coupled plasma (ICP), and electrospray ionization (ESI) MS. For CNDs characterization, LDI-MS, MALDI-MS, and ESI-MS were employed. The techniques required further instrumentations of time-of-flight (TOF), for MALDI, and TOF, quadrupole (Q), and tandem (MS/MS) for ESI. LDI-MS could be applied to prove the surface and core structural composition of carbon nanodots. Meanwhile, MALDI-MS was used to elucidate the surface structures of CNDs. Finally, ESI-MS could provide significant insight into the carbon nanodots' structural composition and bonding patterns. In summary, MS could be combined with other techniques to unambiguously elucidate the structure of carbon nanodots. Nanodot ; Mass spectrometry ; Characterization (materials science) ; Materials science ; Nanomaterials ; Carbon fibers ; Nanotechnology ; Electrospray ionization ; Chemistry ; Analytical Chemistry (journal) ; Chromatography ; Composite number Carbon and Quantum Dots Applications ; Analytical chemistry methods development ; Heavy Metal Exposure and Toxicity
Authors: Svetlana Ivanova | Florian Beuerle
Source: Israel Journal of Chemistry (article, 2024-05-15)
Field: Chemistry — Inorganic Chemistry

Porous Crystalline Organic Cages Made by Design Abstract Shape‐persistent organic cages are an intriguing class of molecular porous materials. Through hierarchical molecular design, size and shape of the intrinsic molecular voids are controlled by dynamic covalent chemistry, while pore structure and topology are governed by noncovalent alignment in the solid state. However, the predictable and reliable crystallization of organic cages is still challenging since long‐range superstructures are solely based on weak and rather unidirectional supramolecular interactions. In this tutorial review, we provide a general classification of porous solid‐state materials and discuss specific design principles regarding the dynamic covalent reactions, the small‐molecule building blocks and solid‐state engineering. Furthermore, we introduce the most important analytical techniques for porous materials with a special focus on organic cages. Porosity ; Materials science ; Chemical engineering ; Composite material ; Engineering Metal-Organic Frameworks: Synthesis and Applications ; Covalent Organic Framework Applications ; Supramolecular Chemistry and Complexes
Authors: D Hazarika | Sumit Sarma | Priyanka Shankarishan
Source: BioTechnologia (review, 2024-09-30)
Field: Materials Science — Biomaterials

Nanotechnology in cancer therapeutics, diagnosis,and management Nanotechnology presents an exciting opportunity in cancer research by offering significant advancements in therapies, diagnosis, and management. It possesses unparalleled potential to enhance the accuracy and effectiveness of cancer therapy while simultaneously reducing adverse effects, owing to its distinctive capability to manipulate matter at a molecular level. Using nanoparticle carriers has facilitated the precise administration of therapeutic agents to afflicted areas within the human body through customized drug delivery systems, resulting in improved treatment accuracy and efficacy while reducing adverse effects. These techniques improve drug solubility and stability, leading to elevated levels of biochemical availability and improved efficacy outcomes for patients with minimal negative effects during treatment cycles. Another use case for nanoparticles includes tumor imaging; functionalized with targeting ligands containing diagnostic agents, they foster early detection, making quicker remedial action plans possible. Overall, the incorporation of nanotechnology ensures a promising future, although it stresses the need to address regulatory hurdles and safety concerns before widespread clinical implementation. Despite the complexity of cancer research and patient care, nanotechnology shows promise in transforming both fields. Nanotechnology ; Cancer ; Medicine ; Engineering ; Materials science ; Internal medicine Nanoparticle-Based Drug Delivery ; Graphene and Nanomaterials Applications
Authors: Mohamed M. Megahed | Noha H. Elashery | Saleh M. Saleh | A. M. El-Shamy
Source: Scientific Reports (article, 2024-03-27)
Field: Materials Science — Materials Chemistry

RETRACTED ARTICLE: Flawless polyaniline coating for preservation and corrosion protection of ancient steel spearheads: an archaeological study from military museum, Al-Qala, Egypt The purpose of this research was to examine the viability of applying a flawless polyaniline coating on steel spearheads to preserve them and protect them from corrosion. The spearpoints, thought to be archaeologically significant, were acquired from the Military Museum in Al-Qala, Egypt. X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy were used to characterize the spearheads chemical composition and microstructure (EDX). The spearheads were determined to be constructed of steel and to have a coating of ferric oxide and other corrosion products on their exteriors. After that, a flawless polyaniline coating was electrochemically deposited onto the spearpoints in a way that was both quick and cheap. Many types of corrosion tests, such as electrochemical impedance spectroscopy and potentiodynamic polarization (PDP) readings, were used to determine the coating's effectiveness. The steel spearheads' findings revealed a significant improvement in their resistance to corrosion after being coated with flawless polyaniline. The coating served as a barrier, blocking out water and other corrosive substances and slowing the buildup of corrosion byproducts on the spearpoints. In conclusion, our research shows that a flawless polyaniline coating may be an effective anti-corrosion treatment for ancient steel artifacts. The approach is straightforward, cheap, and readily scalable for massive conservation efforts. Polyaniline ; Corrosion ; Coating ; Materials science ; Dielectric spectroscopy ; Scanning electron microscope ; Metallurgy ; Microstructure ; Composite material ; Electrochemistry ; Chemistry ; Polymer Corrosion Behavior and Inhibition ; Concrete Corrosion and Durability ; Non-Destructive Testing Techniques
Authors: Nithyashree Jayakumar | J. P. VARGHESE | Abinandh Biju | Gopal Italiya | Nallusamy Sivakumar | Sangeetha Subramanian
Source: Water Practice & Technology (article, 2024-09-26)
Field: Chemistry — Electrochemistry

Antimony and arsenic detection: review on electrochemical biosensors and their applications ABSTRACT Arsenic (As) and antimony (Sb) contamination poses significant health risks, manifesting in a spectrum of ailments such as cardiovascular, respiratory, and skin diseases and the development of cancer. When toxic elements enter the body through different exposure routes, they can cause serious health issues. This highlights the critical need to reduce their presence in the environment to protect public health. When detecting As and Sb in different samples, researchers prefer to use whole-cell and optical biosensors rather than electrochemical (EC) biosensors for reliable detection. Utilizing EC biosensors can significantly enhance the detection thresholds and accuracy of monitoring environmental changes. It is particularly well suited for applications requiring high sensitivity, rapid detection, portability, and cost-effectiveness. For fast onsite environmental monitoring, its portability and quick reaction times are essential. The augmentation of EC biosensors via AI integration has the potential to transform pollution detection, healthcare diagnostics, and food safety monitoring, in addition to enhancing their sensitivity and accessibility. This review highlights the potential benefits of EC biosensors and their diverse applications in environmental monitoring. It critically evaluates strategies aimed at enhancing the efficiency of environmental monitoring processes. Antimony ; Arsenic ; Electrochemistry ; Environmental chemistry ; Biosensor ; Environmental science ; Materials science ; Nanotechnology ; Chemistry ; Metallurgy ; Electrode Electrochemical Analysis and Applications ; Advanced biosensing and bioanalysis techniques ; Electrochemical sensors and biosensors
Authors: Qian Shu Li | Zhiqian Yu | Qianhui Liu | Yusong Guo | Zhangyi Fu | Yudong Yang | Zhengyang Bin | Di Wu | Jingbo Lan
Source: Chemical Science (article, 2024-01-01)
Field: Chemistry — Organic Chemistry

Crafting 1,4-diaryl spirobifluorene hosts in OLEDs <i>via</i> interannular C–H arylation: synergistic effects of molecular linearity and orthogonality In this work, we present a design concept of introducing linear structures into the orthogonal configuration of 9,9'-spirobifluorene (SBF), aiming to enhance carrier mobilities while maintaining high triplet energies (<i>E</i> <sub>T</sub>), which are two critical parameters for optimizing host materials in organic light-emitting diodes (OLEDs). To validate our proposed design, four pivotal model molecules of 1,4-diaryl SBFs were synthesized <i>via</i> interannular C-H arylation of bi(hetero)aryl-2-formaldehydes, a task challenging to accomplish using previous synthetic methodologies. The orthogonal configuration and the steric hindrance of SBF lead to high <i>E</i> <sub>T</sub> through the conjugation breaking at C1 and C4 positions, rendering 1,4-diaryl SBFs suitable as universal pure hydrocarbon (PHC) hosts for red, green, and blue (RGB) phosphorescent OLEDs (PhOLEDs). Meanwhile, the linearity and relatively good planarity of the <i>para</i>-quaterphenyl structure promote high carrier mobilities through orderly intermolecular packing. The synergistic effects of linearity and orthogonality in 1-(<i>para</i>-biphenyl)-4-phenyl-SBF result in exceptional device performance with external quantum efficiencies (EQEs) of 26.0%, 26.1%, and 22.5% for RGB PhOLEDs, respectively. Notably, the green PhOLED exhibits minimal efficiency roll-off, positioning its device performances among the state-of-the-art in PHC hosts. Orthogonality ; OLED ; Linearity ; Chemistry ; Combinatorial chemistry ; Stereochemistry ; Organic chemistry ; Mathematics ; Physics ; Quantum mechanics Catalytic C–H Functionalization Methods ; Catalytic Cross-Coupling Reactions ; Radical Photochemical Reactions
Authors: Aleksandra Grzelakowska | Balaraman Kalyanaraman | Jacek Zielonka
Source: Redox Biochemistry and Chemistry (article, 2024-07-26)
Field: Chemistry — Spectroscopy

Small molecule probes for peroxynitrite detection Peroxynitrite (ONOO<sup>‒</sup>/ONOOH) is a short-lived but highly reactive species that is formed in the diffusion-controlled reaction between nitric oxide and the superoxide radical anion. It can oxidize certain biomolecules and has been considered as a key cellular oxidant formed under various pathophysiological conditions. It is crucial to selectively detect and quantify ONOO<sup>-</sup> to determine its role in biological processes. In this review, we discuss various approaches used to detect ONOO<sup>‒</sup> in cell-free and cellular systems with the major emphasis on small-molecule chemical probes. We review the chemical principles and mechanisms responsible for the formation of the detectable products, and plausible limitations of the probes. We recommend the use of boronate-based chemical probes for ONOO<sup>‒</sup>, as they react directly and rapidly with ONOO<sup>-</sup>, they produce minor but ONOO<sup>‒</sup>‒specific products, and the reaction kinetics and mechanism have been rigorously characterized. Specific experimental approaches and protocols for the detection of ONOO<sup>-</sup> in cell-free, cellular, and <i>in vivo</i> systems using boronate-based molecular probes are provided (as shown in Boxes 1-6). Peroxynitrite ; Chemistry ; Biomolecule ; Peroxynitrous acid ; Nitric oxide ; Superoxide ; Small molecule ; Biophysics ; Combinatorial chemistry ; Nanotechnology ; Biochemistry ; Organic chemistry ; Materials science ; Biology Molecular Sensors and Ion Detection ; Nitric Oxide and Endothelin Effects ; Sulfur Compounds in Biology
Authors: Rita Turnaturi | Silvia Piana | Salvatore Spoto | Giuliana Costanzo | Lorena Reina | Lorella Pasquinucci | Carmela Parenti
Source: Molecules (article, 2024-02-09)
Field: Chemistry — Organic Chemistry

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design Pain is associated with many health problems and a reduced quality of life and has been a common reason for seeking medical attention. Several therapeutics are available on the market, although side effects, physical dependence, and abuse limit their use. As the process of pain transmission and modulation is regulated by different peripheral and central mechanisms and neurotransmitters, medicinal chemistry continues to study novel ligands and innovative approaches. Among them, natural products are known to be a rich source of lead compounds for drug discovery due to their chemical structural variety and different analgesic mechanisms. Numerous studies suggested that some chemicals from medicinal plants could be alternative options for pain relief and management. Previously, we conducted a literature search aimed at identifying natural products interacting either directly or indirectly with opioid receptors. In this review, instead, we have made an excursus including active ingredients derived from plants whose mechanism of action appears from the literature to be other than the modulation of the opioid system. These substances could, either by themselves or through synthetic and/or semi-synthetic derivatives, be investigated in order to improve their pharmacokinetic characteristics and could represent a valid alternative to the opioid approach to pain therapy. They could also be the basis for the study of new mechanisms of action in the approach to this complex and disabling pathology. Opioid ; Mechanism (biology) ; Chronic pain ; Chemistry ; Analgesic ; Drug discovery ; Mechanism of action ; Drug ; Pharmacology ; Biochemical engineering ; Computational biology ; Medicine ; Neuroscience ; Receptor ; Biology ; Biochemistry ; Engineering Chemical synthesis and alkaloids ; Plant-based Medicinal Research ; Pharmacological Effects of Natural Compounds
Authors: Ruiji Li | Ting Ou | Wen Li | Yehao Yan | Wei Li | X.‐Z. QIN | Shouxin Wang
Source: Molecules (review, 2024-11-03)
Field: Materials Science — Materials Chemistry

All-Visible-Light-Activated Diarylethene Photoswitches Photochromic compounds have attracted much attention for their potential applications in photo-actuators, optoelectronic devices and optical recording techniques. This interest is driven by their key photochemical and photophysical properties, which can be reversibly modulated by light irradiation. Among them, diarylethene compounds have garnered extensive investigation due to their excellent thermal stability of both open- and closed-form isomers, robust fatigue resistance, high photocyclization quantum yield and good photochromic performance in both solution and solid phases. However, a notable limitation in expanding the utility of diarylethene compounds is the necessity for ultraviolet light to induce their photochromism. This requirement poses challenges, as ultraviolet light can be detrimental to biological tissues, and its penetration is often restricted in various media. This review provides an overview of design strategies employed in the development of visible-light-responsive diarylethene compounds. These design strategies serve as a guideline for molecular design, with the potential to significantly broaden the applications of all-visible-light-activated diarylethene compounds in the realms of materials science and biomedical science. Diarylethene ; Photochromism ; Visible spectrum ; Photochemistry ; Materials science ; Ultraviolet ; Nanotechnology ; Photoswitch ; Optoelectronics ; Chemistry Photochromic and Fluorescence Chemistry ; Photoreceptor and optogenetics research ; Polydiacetylene-based materials and applications
Authors: Coline Jumeaux | Christopher S. Spicer | Patrick Charchar | Philip D. Howes | Margaret N. Holme | Ma Li | Nicholas Rose | Joe Nabarro | Martin A. Fascione | Md Harunur Rashid | Irene Yarovsky | Molly M. Stevens
Source: Angewandte Chemie International Edition (article, 2024-03-04)
Field: Chemistry — Organic Chemistry

Strain‐Promoted Cycloadditions in Lipid Bilayers Triggered by Liposome Fusion Due to the variety of roles served by the cell membrane, its composition and structure are complex, making it difficult to study. Bioorthogonal reactions, such as the strain promoted azide-alkyne cycloaddition (SPAAC), are powerful tools for exploring the function of biomolecules in their native environment but have been largely unexplored within the context of lipid bilayers. Here, we developed a new approach to study the SPAAC reaction in liposomal membranes using azide- and strained alkyne-functionalized Förster resonance energy transfer (FRET) dye pairs. This study represents the first characterization of the SPAAC reaction between diffusing molecules inside liposomal membranes. Potential applications of this work include in situ bioorthogonal labeling of membrane proteins, improved understanding of membrane dynamics and fluidity, and the generation of new probes for biosensing assays. Bioorthogonal chemistry ; Chemistry ; Förster resonance energy transfer ; Membrane ; Biosensor ; Liposome ; Biomolecule ; Lipid bilayer ; Context (archaeology) ; Biophysics ; Azide ; Click chemistry ; Lipid bilayer fusion ; Cycloaddition ; Combinatorial chemistry ; Fluorescence ; Biochemistry ; Organic chemistry ; Biology Click Chemistry and Applications ; Monoclonal and Polyclonal Antibodies Research ; Advanced biosensing and bioanalysis techniques
Authors: Bin Huang | Manfei Zhou | Qiong‐Yan Hong | Meng‐Xiang Wu | Xiao‐Li Zhao | Lin Xu | En‐Qing Gao | Hai‐Bo Yang | Xueliang Shi
Source: Angewandte Chemie International Edition (article, 2024-06-14)
Field: Chemistry — Inorganic Chemistry

A Redox‐Active Phenothiazine‐based Pd<sub>2</sub>L<sub>4</sub>‐Type Coordination Cage and Its Isolable Crystalline Polyradical Cations Abstract Polyradical cages are of great interest because they show very fascinating physical and chemical properties, but many challenges remain, especially for their synthesis and characterization. Herein, we present the synthesis of a polyradical cation cage 1 4 ⋅ + through post‐synthetic oxidation of a redox‐active phenothiazine‐based Pd 2 L 4 ‐type coordination cage 1 . It′s worth noting that 1 exhibits excellent reversible electrochemical and chemical redox activity due to the introduction of a bulky 3,5‐di‐ tert ‐butyl‐4‐methoxyphenyl substituent. The generation of 1 4 ⋅ + through reversible electrochemical oxidation is investigated by in situ UV/Vis‐NIR and EPR spectroelectrochemistry. Meanwhile, chemical oxidation of 1 can also produce 1 4 ⋅ + which can be reversibly reduced back to the original cage 1 , and the process is monitored by EPR and NMR spectroscopies. Eventually, we succeed in the isolation and single crystal X‐ray diffraction analysis of 1 4 ⋅ + , whose electronic structure and conformation are distinct to original 1 . The magnetic susceptibility measurements indicate the predominantly antiferromagnetic interactions between the four phenothiazine radical cations in 1 4 ⋅ + . We believe that our study including the facile synthesis methodology and in situ spectroelectrochemistry will shed some light on the synthesis and characterization of novel polyradical systems, opening more perspectives for developing functional supramolecular cages. Phenothiazine ; Chemistry ; Redox ; Cage ; Coordination complex ; Crystallography ; Stereochemistry ; Inorganic chemistry ; Organic chemistry ; Metal Metal-Organic Frameworks: Synthesis and Applications ; Supramolecular Chemistry and Complexes ; Crystallography and molecular interactions