jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Dinh Cung Tien Nguyen | Quyen Vu Thi | Quynh H. Nguyen | Jaehyoung Ko | Hoyeon Lee | Bryan W. Boudouris | Seung‐Yeol Jeon | Yongho Joo
Source: npj Flexible Electronics (article, 2025-05-02)
Field: Materials Science — Polymers and Plastics

Engineering flexible dopamine biosensors: blended EGylated conjugated and radical polymers in organic electrochemical transistors We demonstrate an enhancement in the figure of merit (μC*) of a flexible organic electrochemical transistor (OECT) and its dopamine (DA) biosensor by blending various open-shell, non-conjugated radical polymers featuring nitroxide radical active sites as pendant groups with closed-shell, ethylene glycol (EG)-functionalized conjugated polymers as a macromolecular active layer system. The precisely controlled ionic transport of the OECT by the radical polymer modulated the doping level of the EGylated polymer, ensuring well-regulated redox activity and resulting in μC* values exceeding 192 F V-¹ cm-¹ s-¹, along with an on/off ratio of 104. Additionally, we achieved an ultrasensitive detection limit for DA at the clinically relevant level of 1 pM, along with exceptional specificity, effectively distinguishing DA even in the presence of a substantial excess of interfering substances. These findings underscore the potential of a systematic design approach for developing an advanced, flexible OECT-based biosensor platform through the strategic selection and processing of open- and closed-shell macromolecules. Conjugated system ; Biosensor ; Materials science ; Electrochemistry ; Polymer ; Transistor ; Dopamine ; Nanotechnology ; Chemistry ; Electrical engineering ; Engineering ; Electrode ; Voltage ; Composite material ; Neuroscience ; Psychology ; Physical chemistry Conducting polymers and applications ; Electrochemical sensors and biosensors ; Organic Electronics and Photovoltaics
Authors: Debayan Roy | Jack I. Mansell | Giorgia Barison | Song Yu | Rocco Katavic | Ciro Romano | Nikolas Kaltsoyannis | David J. Procter
Source: Angewandte Chemie (article, 2025-07-08)
Field: Chemistry — Organic Chemistry

SmI <sub>2</sub> ‐Catalyzed Coupling of Alkyl Housane Ketones and Alkenes in an Approach to Norbornanes Abstract Cross‐coupling strategies involving strain release have gained significant recent attention for the construction of complex molecular frameworks, particularly in the context of preparing bioisosteres for medicinal chemistry. While the reactivity of cyclopropanes and bicyclo[1.1.0]butanes (BCBs) has been extensively studied, higher homologues are emerging as valuable substrates for synthesis. For example, methods for the fragmentation and coupling of bicyclo[2.1.0]pentane, or housane, ketones show promise but are currently limited in substrate scope. Here, we describe a mild, atom‐economical, samarium diiodide (Sml 2 )‐catalyzed fragmentation and coupling of alkyl and aryl housane ketones with alkenes that grants access to functionalized norbornane structural motifs, not easily accessible by classical cycloaddition approaches, and with considerable potential for further manipulation. Catalysis ; Alkyl ; Chemistry ; Coupling (piping) ; Alkene ; Medicinal chemistry ; Organic chemistry ; Materials science Catalytic C–H Functionalization Methods ; Cyclopropane Reaction Mechanisms ; Radical Photochemical Reactions
Authors: Zhenghao Shi | M. W. Kwok | To Ngai
Source: Collagen and Leather (article, 2025-11-05)
Field: Materials Science — Polymers and Plastics

Porous surface coating fabrication for polyurethane synthetic leather: a review Polyurethane ; Polymer ; Coating ; Environmentally friendly ; Raw material ; Porosity ; Fabrication Polymer composites and self-healing ; Surface Modification and Superhydrophobicity ; Polymer Foaming and Composites
Authors: Chandra Sekhara Rao Boddala | K. Thammi Reddy | Lakshmi Narayana Chennuru | M.V.N. Kumar Talluri
Source: Separation Science Plus (article, 2025-07-01)
Field: Chemistry — Spectroscopy

Stereo‐Selective Separation and Determination of Larotrectinib and Its Isomeric Impurities on a Novel Immobilized Cellulose Tris‐(3‐Chloro‐5‐Methyl Phenyl Carbamate) Chiral Stationary Phase by Using Normal Phase Liquid Chromatography ABSTRACT A specific, sensitive, and accurate chiral analytical method was developed to separate enantiomers and isomers of Larotrectinib using chiral high‐performance liquid chromatography (HPLC). The enantiomers and diastereomers of Larotrectinib were well separated using an immobilized chiral stationary phase in normal‐phase mode operation. Larotrectinib is an orally administered medication that inhibits the activity of tropomyosin receptor kinase (TRK), a specific protein. It helps to suppress tumor cell growth and supports patient survival. Chiral separation of Larotrectinib was achieved using a novel immobilized chiral selector: cellulose‐tris‐(3‐chloro‐5‐methylphenylcarbamate) (CHIRALPAK IK‐3, 250 mm × 4.6 mm, 3 µm) with a mobile phase consisting of n‐hexane, ethanol, methanol, and triethylamine in the ratio of 50:25:25:0.1 (v/v/v/v). The column oven temperature, detection wavelength, and flow rate were maintained at 40°C, 265 nm, and 1.0 mL/min, respectively. The LOD/LOQ values for the Larotrectinib API, S, S‐isomer, R, S‐enantiomer, and R, R‐isomers were 0.012/0.038, 0.01/0.03, 0.011/0.033, and 0.014/0.044 µg/mL, respectively. The relative standard deviation (RSD) values for method and system precision were &lt; 5% and &lt; 2%, respectively. Mean recovery values ranged from 96.8% to 114.9%. The developed method was validated and successfully applied for the determination and identification of Larotrectinib and its enantiomers and diastereomers in the active pharmaceutical ingredient (API) using the CHIRALPAK IK‐3 chiral stationary phase. Carbamate ; Cellulose ; Chromatography ; Phase (matter) ; Tris ; Impurity ; Chemistry ; Chiral stationary phase ; High-performance liquid chromatography ; Organic chemistry Analytical Chemistry and Chromatography ; Cancer therapeutics and mechanisms ; Glycosylation and Glycoproteins Research
Authors: Kaiwen Zeng | Ning Wang | Zhijing Wu | Huisheng Peng
Source: Chemistry - A European Journal (article, 2025-02-14)
Field: Materials Science — Materials Chemistry

Metal‐Backboned Polymers: A New Concept for Thermoelectric Materials Thermoelectric materials, capable of directly converting heat into electricity, offer significant potential for advancing renewable energy solutions. However, conventional thermoelectric materials, typically based on bulky structures, are constrained by the thermoelectric transport paradox. Metal-backboned polymers, emerging as one-dimensional materials designed at the single atom level, offer quantum confinement that enhances electrical conductivity while reducing thermal conductivity, potentially overcoming the above limitations. Herein, we explore the potential of metal-backboned polymers for the development of highly efficient thermoelectric materials, including their synthesis, structural advantages, potential applications and recent advancements. Moreover, current challenges and promising directions for further advancing their performance and applicability in eco-friendly energy technologies are also discussed. Thermoelectric effect ; Thermoelectric materials ; Materials science ; Renewable energy ; Nanotechnology ; Thermoelectric generator ; Electricity ; Thermal conductivity ; Polymer ; Engineering physics ; Electrical engineering ; Engineering ; Composite material ; Physics Advanced Thermoelectric Materials and Devices ; Conducting polymers and applications ; Covalent Organic Framework Applications
Authors: Pin‐Rong Li | Yu‐Chi Wang | Chin‐Wen Chen | Hsu‐I Mao | Yi‐Ting Lee | Zhiyu Yang | Syang‐Peng Rwei
Source: Polymer Engineering and Science (article, 2025-05-07)
Field: Materials Science — Materials Chemistry

Tailoring thermal and electrical conductivity of melt‐spun poly(butylene adipate‐co‐terephthalate) fibers via carbon nanotube incorporation Abstract Antistatic fibers play a crucial role in functional textiles, often incorporating carbon‐based materials like carbon nanotubes (CNTs) to achieve conductivity. However, CNTs tend to aggregate, which is due to strong Van der Waals forces, negatively affecting polymer mechanical properties and dispersibility. This study explores the incorporation of CNTs into poly(butylene adipate‐co‐terephthalate) (PBAT) fibers via twin‐screw extrusion and melt spinning. The effects of CNT content on thermal stability, crystallization, and mechanical properties were evaluated. Differential scanning calorimetry revealed that CNTs acted as nucleating agents, increasing the crystallization temperature ( T c ) by 47.8°C. Thermogravimetric analysis showed enhanced thermal stability, with T d‐5% increasing to 368.6°C at 2 wt% CNT. Rheological studies confirmed improved viscosity and storage modulus, indicating restricted polymer chain mobility. Mechanical testing demonstrated that Young's modulus and yield strength increased with CNT content, while elongation at break decreased due to restricted polymer chain mobility. Electrical conductivity tests indicated a significant drop in surface resistivity from 10 7 to 10 2 Ω/sq at CNT concentrations above 2 wt%. Additionally, thermal drawing improved fiber strength, with fiber stress increasing from 0.378 to 1.63 gf/den at a draw ratio of 3. x‐ray diffraction confirmed that CNTs did not alter the PBAT crystal structure but enhanced crystallinity. Scanning electron microscopy revealed smooth fiber surfaces with uniform dispersion. The study concludes that CNT incorporation enhances PBAT fiber conductivity and strength while maintaining good processability, making it a promising approach for sustainable antistatic applications. Highlights Carbon nanotubes (CNTs) improve conductivity but weaken mechanical properties. Poly(butylene adipate‐co‐terephthalate) (PBAT)/CNT fibers made via twin‐screw extrusion and melt spinning. Thermal drawing boosts strength by adjusting draw ratio. CNTs enhance T c as nucleating agents in PBAT. Fiber strength rises from 0.378 to 1.63 gf/den after drawing. CNTs boost conductivity but reduce mechanical strength. PBAT/CNT fibers made by twin‐screw extrusion and melt spinning. Thermal drawing improves strength via draw ratio control. CNTs raise Tc by acting as nucleating agents in PBAT. Drawing raises fiber strength from 0.378 to 1.63 gf/den. Materials science ; Adipate ; Carbon nanotube ; Composite material ; Thermal conductivity ; Thermal ; Nanotube ; Polyester ; Electrical resistivity and conductivity ; Chemical engineering Carbon Nanotubes in Composites ; Conducting polymers and applications ; Fiber-reinforced polymer composites
Authors: N. Jang | Tran Quang Linh | Mai Toan | Kiok Kwon | Seunghan Shin
Source: Polymers (article, 2025-01-17)
Field: Materials Science — Polymers and Plastics

Enhancing the Mechanical and Adhesive Properties of Polyurethane Adhesives with Propylene Oxide-Modified Ethylenediamine (PPO-EDA) This study explores the use of propylene oxide-modified ethylenediamine (PPO-EDA) as a novel crosslinker and chain extender in polyurethane (PU) adhesives. PPO-EDA was synthesized and compared with <i>N</i>,<i>N'</i>-dimethylethylenediamine (DMEDA) to assess its impact on mechanical properties and adhesion performance. Key parameters such as NCO conversion, tensile strength, and lap shear strength were thoroughly evaluated. The results demonstrated that incorporating PPO-EDA significantly improved NCO conversion and crosslink density, leading to notable enhancements in tensile strength and elastic modulus compared to DMEDA. Lap shear tests further revealed superior adhesion performance in PPO-EDA-modified PU adhesives, particularly on amine silane-treated steel substrates, where lap shear strength consistently outperformed other samples. This improved performance was attributed to PPO-EDA's dual role as a chain extender and crosslinker, which strengthened the adhesive's structural integrity. This study underscores the effectiveness of PPO-EDA as a modifier for enhancing both mechanical and adhesive properties in PU-based adhesives, offering a promising solution for optimizing high-performance adhesives in automotive and industrial applications. Adhesive ; Materials science ; Polyurethane ; Composite material ; Ultimate tensile strength ; Ethylenediamine ; Shear strength (soil) ; Chemistry ; Organic chemistry Polymer composites and self-healing ; Silicone and Siloxane Chemistry ; Synthesis and properties of polymers
Authors: José de Jesús Velazquez-Garcia | L. De Los Santos Valladares | C. H. W. Barnes | Sandra König | Michael Fröba | Volodymyr Baran | Bassima Knjo | Faegheh Khademhir | Aliyenur Ekineken | Fabienne Hain | Evke Carstensen | Tom Spillner | Lina Asprilla Herrera | Weronika Łukaszczyk | Simone Techert
Source: Dalton Transactions (article, 2025-01-01)
Field: Chemistry — Inorganic Chemistry

Neutral and ionic Co(<scp>ii</scp>) metal–organic frameworks with 2-methylimidazole and trimesate: design and evaluation for molecule encapsulation and slow release Two Co(II) mixed-ligand metal-organic frameworks (MOFs) based on 2-methylimidazole and trimesate were synthesised at room temperature. The structure and properties of the two MOFs, named material Deutsches Elektronen Synchrotron-1 and -2 (mDESY-1 and mDESY-2), were verified by single crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), SQUID magnetic susceptibility and N<sub>2</sub> adsorption. The structural analysis indicates that mDESY-1 is a 3D ionic framework with 2-methyl-1<i>H</i>-imidazol-3-ium counterions residing in its pores, while mDESY-2 is a 2D neutral framework isostructural to ITH-1, with water as a co-crystallising solvent. PXRD data demonstrates that mDESY-1 exhibits better crystallinity than mDESY-2. Magnetic measurements indicate that both MOFs are paramagnetic with a weak ferromagnetic transition above room temperature. Although both structures suggest the presence of voids, N<sub>2</sub> adsorption data confirms that these voids are not accessible in either MOF. Nevertheless, mDESY-1 was capable of encapsulating azobenzene during synthesis, which was observed <i>via</i> SCXRD. The encapsulated molecules were then slowly released in ethanol, with a release of up to 30 mg of azobenzene per g of MOF in a period of 60 days. Encapsulation (networking) ; Metal-organic framework ; Ionic bonding ; Molecule ; Chemistry ; Metal ; Nanotechnology ; Combinatorial chemistry ; Materials science ; Ion ; Organic chemistry ; Adsorption ; Computer science Metal-Organic Frameworks: Synthesis and Applications ; X-ray Diffraction in Crystallography ; Lanthanide and Transition Metal Complexes
Authors: Helena Uceta | Daniel Gallego‐Fuente | Pablo Ares | Myriam Barrejón | Julio Gómez‐Herrero | Fernando Langa
Source: Carbon (article, 2025-10-15)
Field: Materials Science — Materials Chemistry

Non-disruptive functionalization of carbon nanotubes: Toward enhanced device performance with double-walled hybrid materials Non-disruptive covalent functionalization of single-walled carbon nanotubes (SWCNTs) and double-walled carbon nanotubes (DWCNTs) with different azido aryl derivatives and varying degrees of functionalization has been successfully achieved. The synthetic method is based on the reaction of 4-azido-N,N-dimethylaniline and 4-azidobenzonitrile with carbon nanotubes (CNTs) via [2+1] nitrene cycloaddition, yielding fully conjugated hetero-bridged CNTs that preserve the intrinsic π -conjugated system of pristine CNTs. Evidence of covalent functionalization is deduced from different studies, including thermogravimetric analysis, X-Ray photoelectron spectroscopy (XPS), and Raman spectroscopy. The successful incorporation of a non-disruptive ‘open-ring’ aziridine bridge onto the nanotube sidewalls has been demonstrated through various techniques such as Raman, UV-Vis and photoluminescence (PLE) spectroscopies. Finally, the electrical transport properties of the functionalized materials have been studied by fabricating CNT-based devices and acquiring their current vs. voltage characteristics. Our results suggest that the conductance of the functionalized CNTs is mostly preserved in DWCNTs. So treated DWCNTs exhibit electrical conductance of the same order of magnitude as the pristine/control devices. These findings highlight the potential of this synthetic approach to enhance the processability and tailor the properties of DWCNTs for specific applications. Notably, aziridine-functionalized DWCNT-based devices exhibit excellent electrical characteristics, paving the way for systems with promising applications in optoelectronics. Surface modification ; Carbon nanotube ; Hybrid material ; Raman spectroscopy ; X-ray photoelectron spectroscopy ; Covalent bond ; Carbon fibers Carbon Nanotubes in Composites ; Graphene research and applications ; Fullerene Chemistry and Applications
Authors: Anna‐Lisa Poser | Thorsten Pretsch
Source: Macromolecular Rapid Communications (article, 2025-02-06)
Field: Materials Science — Polymers and Plastics

FOIM: Thermal Foaming of Shape Memory Polyurethane Foil This work introduces the semi-finished product FOIM, a neologism from FOIl and foaM, a phase segregated polyester urethane urea (PEUU) foam, which is synthesized from poly(1,6-hexylene adipate) diol, 4,4'-methylene diphenyl diisocyanate, polyethylene glycol and water as blowing agent. The PEUU is obtained by following a one-shot synthesis and is characterized by a hard/soft segment ratio of 1.06 and an open pore content of 78%. Differential scanning calorimetry reveals a melting peak at 45 °C and a crystallization signal at 14 °C, both of which are associated with the phase transitions of the soft segment. The glass transition temperature, which is determined as a local maximum within the tan δ using dynamic mechanical analysis, is 1 °C. During programming, the foam is heavily compressed at 60 °C. Once unloaded at 23 °C, a translucent foil, the FOIM, is obtained. When reheated to 60 °C, the foil switches back to the foam due to its pronounced shape memory properties. Intriguingly, the structure remains largely unaffected by the drastic deformation as indicated by buoyancy and heat transmission measurements. The ease of manufacture and functionality makes the technology attractive for applications, in which both low transport volumes and drastic shape changes are desired. Materials science ; Differential scanning calorimetry ; Polyurethane ; FOIL method ; Glass transition ; Composite material ; Adipate ; Blowing agent ; Polyester ; Polymer chemistry ; Chemical engineering ; Polymer Polymer composites and self-healing ; Silicone and Siloxane Chemistry ; Polydiacetylene-based materials and applications
Authors: Stefania Lamponi | Roberta Barletta | Annalisa Santucci
Source: Life (article, 2025-12-13)
Field: Materials Science — Biomaterials

Agricultural and Agro-Industrial Residues as Sustainable Sources of Next-Generation Biomedical Materials: Advances, Challenges, and Perspectives Agricultural and agro-industrial residues are increasingly recognized as sustainable, low-cost feedstocks for high-performance biomedical materials. This review critically examines the translational potential of polysaccharides, proteins, inorganic compounds, and phytochemical-rich extracts derived from agro-waste, highlighting their chemical features, structure-function relationships, and application-specific readiness. Polysaccharides such as nanocellulose, pectin, and chitosan emerge as the most advanced biopolymer platforms, particularly in wound healing, drug delivery, and 3D-printed scaffolds. Protein-derived materials-including collagen, gelatin, keratin, and soy protein-show strong promise in regenerative medicine, though challenges in mechanical stability and batch reproducibility remain. Inorganic phases such as hydroxyapatite and silica obtained from eggshells, rice husk ash, and marine shells demonstrate high bioactivity, with dental and bone applications approaching clinical translation. Finally, fruit-residue phytochemicals provide multifunctional antioxidant and antimicrobial enhancements to composite systems. By integrating material chemistry, processing strategies, and translational considerations, this review outlines the current state, challenges, and future perspectives for advancing agro-waste-derived biomaterials within a circular bioeconomy. Biopolymer ; Agriculture ; Drug delivery ; Antimicrobial ; Regenerative medicine ; Sustainability Nanocomposite Films for Food Packaging ; Collagen: Extraction and Characterization ; Polysaccharides and Plant Cell Walls
Authors: Emma G. L. Robert | Jérôme Waser
Source: Chemical Science (article, 2025-01-01)
Field: Chemistry — Organic Chemistry

Enantioselective synthesis of 1,2-disubstituted thiocyclobutanes <i>via</i> Michael addition We report the diastereoselective and enantioselective synthesis of thio-substituted cyclobutanes <i>via</i> a sulfa-Michael addition using cyclobutenes. In the presence of DBU, various thio-cyclobutane esters and amides were obtained in up to quantitative yield and >95 : 5 dr. Using a chiral chinchona-based squaramide bifunctional acid-base catalyst and an <i>N</i>-acyl-oxazolidinone-substituted cyclobutene, thio-cyclobutanes were obtained with high yield and enantioselectivity (er up to 99.7 : 0.3). Enantioselective synthesis ; Michael reaction ; Combinatorial chemistry ; Chemistry ; Stereochemistry ; Organic chemistry ; Catalysis Sulfur-Based Synthesis Techniques ; Synthesis and Catalytic Reactions ; Chemical Synthesis and Reactions
Authors: Arshia Sulaiman | Mohammad Khurram Javed | Carl Fossum | Conor Long | M. Léonard | Minliang Yan | Mikaela C. Boyanich | Naveen Kumar | Alex Balboa | Hui Wang | Eric M. Johnson | John J. Mahle | Christopher J. Karwacki | Jenny V. Lockard | Diego Troya | John R. Morris | Amanda J. Morris
Source: Catalysis Science & Technology (article, 2025-01-01)
Field: Materials Science — Materials Chemistry

Manganese single-atom modification of MOF-808 for catalytic nerve agent and simulant degradation Single-atom Mn sites on MOF-808 catalyze sarin simulant degradation under solid, unbuffered conditions. Spectroscopic and computational results show altered product binding that mitigates poisoning and sustains reactivity. Catalysis ; Manganese ; Degradation (telecommunications) ; Nerve agent ; Sarin Catalytic Processes in Materials Science ; Catalysis and Hydrodesulfurization Studies ; Catalysis and Oxidation Reactions