jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Agnieszka Stawarska | Magdalena Bamburowicz‐Klimkowska | Wojciech Szeszkowski | Ireneusz P. Grudziński
Source: Nanomaterials (article, 2025-08-18)
Field: Materials Science — Biomaterials

Dynamic Susceptibility Contrast Magnetic Resonance Imaging with Carbon-Encapsulated Iron Nanoparticles Navigated to Integrin Alfa V Beta 3 Receptors in Rat Glioma Overexpression of αvβ3 integrin is found in a diverse group of tumors originating from glial cells in the brain, making this transmembrane receptor a promising biomarker for molecular MRI diagnosis. In the study, we conjugated a monoclonal antibody against the β3 subunit (CD61) of the αvβ3 integrin receptor with carbon-encapsulated iron nanoparticles to yield Fe@C-(CH<sub>2</sub>)<sub>2</sub>-CONH-anti-CD61 bioconjugates that were used in dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI). Wistar rats bearing C6 gliomas were injected as a single bolus (0.5 mL) through the tail vain with a suspension of Fe@C-(CH<sub>2</sub>)<sub>2</sub>-CONH-anti-CD61 nanoparticles (200 μg mL<sup>-1</sup>) and the animals were imaged using the T2*-weighted echo planar imaging (T2* EPI) technique. Results showed that intravenously infused nanoparticles targeting αvβ3 integrin receptors provide strong contrast in rat glioma tissues. No such effects were observed in other rat organs, although some post-contrast effects were also noted in the liver and kidney. The study shows that the as-developed nanoparticles decorated with anti-CD61 monoclonal antibodies might be considered as a novel contrast candidate for noninvasive DSC-MRI diagnosis in CD61-positive gliomas. Integrin ; Magnetic resonance imaging ; Glioma ; Chemistry ; Receptor ; Monoclonal antibody ; Pathology ; MRI contrast agent ; Biophysics ; Nuclear magnetic resonance ; Medicine ; Antibody ; Cancer research ; Biology ; Biochemistry ; Immunology ; Radiology Nanoparticle-Based Drug Delivery ; Cell Adhesion Molecules Research ; Nanoplatforms for cancer theranostics
Authors: Hyung-Kyu Lee | Goeun Kim | Seong-Ho Jang | Young‐Chae Song
Source: Water (article, 2025-06-27)
Field: Chemistry — Organic Chemistry

Synergistic Effects of a Packed Bed Bipolar Electrolysis System Combined with Activated Carbon for Efficient Treatment of Dyeing Wastewater Textile dyeing wastewater is one of the most challenging industrial effluents to treat due to its high concentrations of persistent organic compounds and nitrogenous substances. Conventional treatment methods often fall short in achieving both sufficient removal efficiency and environmental safety. In this study, we aimed to remove the total nitrogen (T-N) and total organic carbon (TOC) of dyeing wastewater from an industrial complex in D City, Korea, by applying bipolar and packed bipolar electrolysis using aluminum (Al) electrodes and activated carbon (AC). The system was operated for 60 min under varying conditions of applied voltage (5–15 V), electrolyte type and concentration (non-addition, NaCl 5 mM, NaCl 10 mM, Na2SO4 5 mM, Na2SO4 10 mM), and AC packing amount (non-addition or 100 g/L). The highest T-N and TOC removal efficiencies were observed at 15 V, reaching 69.53% and 63.68%, respectively. Electrolyte addition significantly improved initial treatment performance, with NaCl 10 mM showing the best results. However, Al leaching also increased, from 549.83 mg/L (non-addition) to 623.06 mg/L (NaCl 10 mM). When AC was used without electrolysis (control experiment), the T-N and TOC removal efficiencies were limited to 30.24% and 29.86%, respectively. In contrast, AC packing combined with 15 V electrolysis under non-addition achieved 86.04% T-N and 77.98% TOC removal, while also reducing Al leaching by 40.12%. These results suggested that electrochemical treatment with AC packing under non-addition conditions offers the best balance between high treatment efficiency and low environmental impact. These findings demonstrate that the synergistic use of packed activated carbon and electrochemical treatment under additive-free conditions can overcome the limitations of conventional methods. This study contributes to the development of more sustainable and effective technologies for treating high-strength industrial wastewater. Electrolysis ; Activated carbon ; Wastewater ; Packed bed ; Dyeing ; Waste management ; Environmental science ; Pulp and paper industry ; Materials science ; Chemistry ; Process engineering ; Chromatography ; Engineering ; Adsorption ; Composite material ; Electrode ; Organic chemistry ; Electrolyte Nanomaterials for catalytic reactions ; Adsorption and biosorption for pollutant removal ; Advanced oxidation water treatment
Authors: Gábor Németi | Róbert Berkecz | Dániel Ozsvár | Zsolt Szakonyi | Wolfgang Lindner | Aleksandra Misicka | Dagmara Tymecka | Géza Tóth | Antal Péter | István Ilisz
Source: International Journal of Molecular Sciences (article, 2025-04-23)
Field: Chemistry — Spectroscopy

High-Performance Liquid Chromatographic Separation of Stereoisomers of ß-Methyl-Substituted Unusual Amino Acids Utilizing Ion Exchangers Based on Cinchona Alkaloids Novel peptides based on common amino acid building blocks may serve as possible drug candidates; however, their flexible structures may require stabilization via the incorporation of conformational constraints. The insertion of unusual amino acids is a feasible option that may provide improved pharmacokinetic and pharmacodynamic properties of such peptide-type drugs. The stereochemical purity of these kinds of building blocks must be verified by an efficient separation technique, such as high-performance liquid chromatography. Here, we present and discuss the results of the stereoselective separation mechanism of <i>ß</i>-methylated phenylalanine (<i>ß</i>-MePhe), tyrosine (<i>ß</i>-MeTyr), 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (<i>ß</i>-MeTic), and cyclohexylalanine (<i>ß</i>-MeCha) together with non-methylated Phe, Tyr, Tic, and Cha applying <i>Cinchona</i> alkaloid-based chiral stationary phases (CSPs). The studied zwitterionic CSPs acting as ion exchangers provided optimal performance in the polar ionic mode when methanol or a mixture of methanol and acetonitrile was utilized as the mobile phase together with organic acid and base additives. It was found that the basicity of small amines applied as mobile phase additives did not directly influence the chromatographic ion exchange concept. However, the size of the amines and their concentration led to a reduced retention time following the principles of ion exchange chromatography. On the basis of a systematic study of the effects of the eluent composition on the chromatographic behavior, important structure-retention and enantioselectivity relationships could be revealed. Through a temperature study, it has become evident that the composition of the eluent and the structure of analytes markedly affect the thermodynamic properties. Chemistry ; Amino acid ; Ion chromatography ; Enantiomer ; Cinchona ; Ion exchange ; Chromatography ; Column chromatography ; Amine gas treating ; Organic chemistry ; Ion ; Enantioselective synthesis ; Catalysis Analytical Chemistry and Chromatography ; Chromatography in Natural Products ; Microfluidic and Capillary Electrophoresis Applications
Authors: Somnath N. Chavanke | Sunil G. Dalvi
Source: Scientific Reports (article, 2025-09-30)
Field: Materials Science — Biomaterials

‘Bioinspired nano-architected chitosan-β-glucan nanocomposite as an elicitor for disease management sustainably’ The development and utilization of innovative nano-biomaterials have ushered in a paradigm shift in sustainable disease management and immune modulation. Their application is crucial in combating the soil-born pathogen Sclerotium rolfsii, which impacts over 500 crops, causing substantial global economic losses. Present work reports a groundbreaking innovative development strategy of nanoengineering of chitosan-yeast β-glucan (C-YB) as well as chitosan-S. rolfsii β-glucan (C-SB) composites to bio-mimic Microbe/Pathogen-Associated Molecular Patterns (M/PAMPs) for synergistic immune stimulation while countering immune suppression induced by pathogen. The eco-friendly, microwave-based synthesized nanocomposites exhibit remarkable antifungal properties and feature an amorphous structure with spherical shapes measuring 96.81 nm for C-YB and 98.66 nm for C-SB. These nanocomposites completely suppress S. rolfsii at concentrations as low as 220 ppm for C-YB and 240 ppm for C-SB, significantly outperforming chitosan nanoparticles (600 ppm) and chemical fungicides (2000 ppm). Further, this study highlights the modulation of enzymatic activity and chitinase and β-glucanase enzyme secretion by S. rolfsii which is the first report, offering new insights into its enzymatic dynamics. Exploring the antifungal mechanism of action, microscopic observation reveals that these synthesized nanomaterials induce malformations and cellular disorganization in S. rolfsii, culminating in growth inhibition and cell death. This strategic framework introduces innovative bioengineered nanocomposites with aims to enhance resilience by orchestrating a series of immune responses to various stresses in sugarbeet. These advancements not only contribute to the bio-circular economy but also hold promising potential for versatile applications across agriculture, pharmaceuticals, medical and industrial fields. Immune system ; Nanocomposite ; Fungicide ; Chitinase ; Antifungal ; Sclerotium ; Nanomaterials ; Nanobiotechnology ; Enzyme ; Acquired immune system Nanocomposite Films for Food Packaging ; Polysaccharides and Plant Cell Walls ; Studies on Chitinases and Chitosanases
Authors: Jinlong Wang | Guangyi Huang | Quan Qin | Nianhua Dan | Xin‐Lou Li | Kai Sun | Yuan Yang | Meng Wang
Source: Frontiers in Bioengineering and Biotechnology (article, 2025-09-17)
Field: Materials Science — Biomaterials

Performance study of ZnO-TPU/CS bilayer composite electrospinning scaffold in skin wound healing The bilayer TPU/CS@ZnO scaffold integrates structural protection with biological activity, accelerating wound repair through multiple mechanisms. These findings support its potential as a multifunctional wound dressing, while further studies are needed to clarify molecular pathways and advance clinical application. Scaffold ; Bilayer ; Electrospinning ; Wound healing ; Composite number ; Lipid bilayer Electrospun Nanofibers in Biomedical Applications ; Wound Healing and Treatments ; Silk-based biomaterials and applications
Authors: Hongyu Liu | Yaqin Wang | Xicheng Wang | Rui Liu | Peng Zhang
Source: Powders (article, 2025-10-23)
Field: Materials Science — Materials Chemistry

TiO2 Nanoparticles in Soil: Adsorption, Transformation, and Environmental Risks Titanium-containing nanoparticles have emerged as materials of significant technological importance due to their multifunctional properties and excellent performance. With their expanding applications, the amount of TiO2 nanoparticles (TNPs) being released into the soil environment has increased significantly. This review addresses the gap in current research, which has predominantly focused on the environmental behavior of TNPs in aquatic systems while lacking systematic integration of the synergetic mechanism of adsorption–transformation–ecological effects in soil systems and its guiding value for practical applications. It deeply reveals the interaction mechanisms between TNPs and environmental pollutants. TNPs exhibit outstanding adsorption performance towards environmental pollutants such as heavy metals and organic compounds. Specifically, the maximum adsorption capacities of titanate nanowhiskers for the heavy metal ions Cu(II), Pb(II), and Cr(III) are 143.9 mg·g−1, 384.6 mg·g−1, and 190.8 mg·g−1, respectively. Additionally, 1-hydroxydinaphthoic acid surface-modified nano-TiO2 exhibits an adsorption rate of up to 98.6% for p-nitrophenol, with an enrichment factor of 50-fold. The transformation process of TNPs after pollutant adsorption profoundly affects their environmental fate, among which pH is a critical controlling factor: when the environmental pH is close to the point of zero charge (pHpzc = 5.88), TNPs exhibit significant aggregation behavior and macroscopic sedimentation. Meanwhile, factors such as soil solution chemistry, dissolved organic matter, and microbial activities collectively regulate the aggregation, aging, and chemical/biological transformation of TNPs. In the soil ecosystem, TNPs can exert both beneficial and detrimental impacts on various soil organisms, including bacteria, plants, nematodes, and earthworms. The beneficial effects include alleviating heavy metal stress, serving as a nano-fertilizer to supply titanium elements, and acting as a nano-pesticide to enhance plants’ antiviral capabilities. However, excessively high concentrations of TiO2 can stimulate plants, induce oxidative stress damage, and impair plant growth. This review also highlights promising research directions for future studies, including the development of safer-by-design TNPs, strategic surface modifications to enhance functionality and reduce risks, and a deeper understanding of TNP–soil microbiome interactions. These avenues are crucial for guiding the sustainable application of TNPs in soil environments. Adsorption ; Pollutant ; Heavy metals ; Metal ; Nanoparticle ; Metal ions in aqueous solution Nanoparticles: synthesis and applications
Authors: Abuzar Mehdi Khan | Adila Iram | Hamza Jabbar | Muhammad Abbas | Ghulam Mujtaba | Sabeena Usman | Mohammad Khalid | Qurat ul Ain | Shumaila Naz | Shazia Rafique
Source: Haya The Saudi Journal of Life Sciences (article, 2025-12-15)
Field: Materials Science — Materials Chemistry

One-Health Nanotoxicology at the Nano–Bio Interface: Cross-Taxa Multimodal Biomarkers of Nanoparticle and Metal Exposure and Toxicity Enzymatic, Mirna/Omics, Histopathological, Behavioral, and Edna Evidence Nanoparticles and metals increasingly intersect with biological systems, demanding biomarkers that are mechanistically informative, field-deployable, and interpretable across species. Framed within a One-Health perspective, this literature review synthesizes evidence on the nano–bio interface from molecular to ecosystem scales. We first situate exposure pathways, environmental fate, and bioavailability highlighting agglomeration, protein corona dynamics, dissolution/redox cycling, and uptake routes that condition internal doses. We then map mechanistic cascades (oxidative stress, immune modulation, genotoxic/epigenetic regulation, tissue injury/repair) onto Adverse Outcome Pathways (AOPs) to clarify where biomarker families read out along the continuum from initiating events to organismal and population effects. Assay domains are examined comparatively: enzymatic/biochemical markers (e.g., CAT, SOD, GPx, LPO), miRNA and broader omics (transcriptomic/proteomic/metabolomic pathways), histopathology and digital pathology, behavioral/physiological endpoints, and environmental DNA (eDNA) biosurveillance. Cross-taxa synthesis spans aquatic vertebrates and invertebrates, amphibians/reptiles, and birds/mammals, distilling concordance/discordance patterns among endpoints and contexts. For multimodal inference, we review Weight-of-Evidence, multivariate panel construction (PCA/PLS/clustering), and probabilistic/Bayesian fusion with attention to calibration and uncertainty. Quality and standards are emphasized (controls, effect sizes, MIQE/FAIR/GLP elements) alongside nano/metal-specific interferences and key confounders (life stage, genotype, co-stressors, matrix effects, particle traits/metal speciation). Applications span aquaculture health, wildlife conservation, environmental compliance, and translational/clinical monitoring. We identify critical gaps—chronic low-dose and mixture exposures, under-studied taxa/ecosystems, longitudinal field realism—and propose minimal core panels for lab screening and field deployment, plus a staged roadmap for method harmonization, reference materials, and open data resources. Collectively, the review outlines a path to robust, cross-taxa biomarker architectures that strengthen nanotoxicology inference and One-Health decision-making. Adverse Outcome Pathway ; Nanotoxicology ; Biobank ; Population ; Biomarker ; Sentinel species ; Interactome ; Environmental toxicology ; Affordance Nanoparticles: synthesis and applications ; Environmental Toxicology and Ecotoxicology ; Diatoms and Algae Research
Authors: Ali Golchin | Maryam Rahnama | Mohammad Saleh Chapani | Forough Shams | Mahmood Rekabgardan | Zahra Poursalehi | Parviz Ranjbarvan
Source: The Open Dermatology Journal (article, 2025-07-14)
Field: Materials Science — Biomaterials

Tissue Engineering in Cosmetics and Dermatology: A New Era of Innovation and Application The convergence of tissue engineering and the cosmetic industry marks a transformative axis in the development of advanced cosmetic products and therapies. The current study explores the recent landscape and future potential of applying tissue engineering techniques within the cosmetic industry. The study highlights key innovations, such as the development of lab-grown skin for product testing and personalized skin grafts for aesthetic enhancements, which not only promise to enhance product efficacy and safety but also offer sustainable and ethical alternatives to traditional methods reliant on animal testing. This study reviews scientific progress in biomaterials, scaffold design, and cellular manipulation that promote skin tissue regeneration and repair, wound healing, breast implants, and oral care, highlighting the capacity to tackle intricate aesthetic issues such as scarring, skin aging, and pigmentation disorders. The ethical, regulatory, and economic implications of integrating tissue engineering into cosmetics are also discussed, providing a comprehensive overview of the challenges and opportunities facing this burgeoning field. By advancing the capabilities of cosmetic applications, tissue engineering not only pioneers innovative solutions for personalized beauty care and dermatology but also sets a precedent for future interdisciplinary collaborations in cosmetic science. Cosmetics ; Dermatology ; Medicine ; Pathology Electrospun Nanofibers in Biomedical Applications ; Silk-based biomaterials and applications ; Wound Healing and Treatments
Authors: Chao Sun | Shuqiang Li | Jianxun Ding
Source: Nanomedicine (review, 2025-01-12)
Field: Materials Science — Biomaterials

Biomaterials-mediated biomineralization for tumor blockade therapy Recent advancements in tumor therapy have underscored the potential of biomaterials-mediated biomineralization for tumor blockade. By precisely regulating biomineralization and constructing nanomineralized structures at the cellular level, this therapy achieves multi-dimensional targeted inhibition of tumors. Mineralized precursor molecules are engineered to selectively recognize and bind to proteins on the tumor cell membrane, obstructing signal transduction. Biomineralized materials directly target the tumor cell membrane, disrupting its biological functions and inducing cell apoptosis. Additionally, these materials infiltrate the mitochondria of tumor cells, disrupting energy metabolism through mineralization and significantly impairing tumor viability. This biomaterials-mediated approach enhances treatment precision and efficacy while mitigating side effects, offering a unique approach to tumor therapy. Biomineralization ; Blockade ; Medicine ; Engineering ; Internal medicine ; Chemical engineering ; Receptor Nanoparticle-Based Drug Delivery ; Bone Tissue Engineering Materials ; Nanoplatforms for cancer theranostics
Authors: Natália Bilesky‐José | Renata de Lima
Source: Frontiers in Microbiology (article, 2025-12-02)
Field: Materials Science — Materials Chemistry

Biogenic nanoparticles from bacteria: a perspective on integrated applications in sustainable agriculture The growing demand for sustainable agricultural solutions has driven the development of technologies that contribute to modern agriculture, which aims to achieve greater productivity while maintaining environmental responsibility. Biogenic nanoparticles (BNPs) synthesized using bacteria are emerging as a promising alternative to conventional methods, offering a green approach for producing nanomaterials with agricultural applications. This Perspective highlights the mechanistic basis of bacterial nanoparticle biosynthesis and strategies for genetic and metabolic optimization to enhance yield and functionality, accentuating their potential applications as phytosanitary agents and controlled-release fertilizers. We further propose an integrative "BNP-Plant-Microbiome" framework, in which microbial consortia and multi-nanoparticle formulations could synergistically deliver nutrients, boost stress resilience, and suppress pathogens. Future progress will depend on addressing key challenges in biosafety, regulatory compliance, and large-scale bioprocessing, as well as integrating BNPs with precision agriculture and data-driven monitoring tools. Ultimately, bacterial BNPs have the potential to redefine agricultural sustainability by coupling microbial innovation with circular, resource-efficient crop management systems. Sustainability ; Agriculture ; Productivity ; Sustainable agriculture ; Agricultural productivity ; Sustainable development Nanoparticles: synthesis and applications ; Plant-Microbe Interactions and Immunity ; Bacterial biofilms and quorum sensing
Authors: Mohammad Alnaief | Balsam T. Mohammad | Ibrahem Altarawneh | Dema Alkhatib | Zayed Al-Hamamre | Hadeia Mashaqbeh | Khalid Bani‐Melhem | Rana Obeidat
Source: Gels (article, 2025-09-26)
Field: Chemistry — Spectroscopy

Hybrid Alginate-Based Polysaccharide Aerogels Microparticles for Drug Delivery: Preparation, Characterization, and Performance Evaluation Hybrid polysaccharide-based aerogels offer significant potential as advanced drug delivery platforms due to their tunable structure, high porosity, and biocompatibility. In this study, aerogel microparticles were synthesized using alginate, pectin, carrageenan, and their hybrid formulations via an emulsion-gelation technique followed by supercritical fluid CO<sub>2</sub> extraction. The resulting aerogels exhibit mesoporous structures with specific surface areas ranging from 324 to 521 m<sup>2</sup>/g and pore volumes between 1.99 and 3.75 cm<sup>3</sup>/g. Comprehensive characterization (SEM, gas sorption, XRD, TGA, DSC, and FTIR) confirmed that hybridization improved morphological uniformity and thermal stability compared to single polymer aerogels. Ibuprofen was used as a model drug to evaluate loading efficiency and release kinetics. Among all formulations, the alginate/carrageenan (2:1) hybrid showed the highest drug loading efficiency (93.5%) and a rapid release profile (>90% within 15 min), closely matching the performance of commercial ibuprofen tablets. Drug release followed Fickian diffusion, as confirmed by the Korsmeyer-Peppas model (R<sup>2</sup> > 0.99). These results highlight the potential of hybrid polysaccharide aerogels as vehicles for drug delivery and other fast-acting therapeutic applications. Aerogel ; Ibuprofen ; Supercritical fluid ; Drug delivery ; Polymer ; Drug ; Mesoporous material Aerogels and thermal insulation ; Hydrogels: synthesis, properties, applications ; Mesoporous Materials and Catalysis