jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Tamara M. Iakimova | Benjamin Heidt | Amy Q. Shen
Source: Cell Reports Physical Science (article, 2024-03-05)
Field: Chemistry — Analytical Chemistry

Surface-imprinted polymers based on 3D printing resin for selective bacteria detection Surface-imprinted polymers (SIPs) are biomimetic receptors that emulate the molecular recognition capabilities of antibodies but offer enhanced stability. Traditional contact imprinting for SIP fabrication is labor intensive and can produce inconsistent results due to the manual polymer synthesis. Laying the groundwork for future SIP imprinting with three-dimensional (3D) printers, our study pioneers the use of the Formlabs clear 3D printing resin for creating SIPs geared toward bacterial detection, thus eliminating the manual synthesis step. We produce SIPs using E. coli as a benchmark template bacterium, analyze their structure, and assess their rebinding capacity through fluorescence microscopy. To test cross-selectivity, SIPs for five other bacterial strains are produced and subsequently exposed to each, underscoring the SIPs’ specific affinity for their original bacterial mold. Given its 3D printing suitability and the material’s commercial availability, we envision the use of bacteria-binding imprints on intricate surfaces, bolstering biosensing applications in biotechnology, industry, and environmental monitoring. Molecularly imprinted polymer ; Polymer ; Bacteria ; Materials science ; Nanotechnology ; Chemistry ; Composite material ; Selectivity ; Organic chemistry ; Biology ; Catalysis Analytical chemistry methods development ; Innovative Microfluidic and Catalytic Techniques Innovation ; Microfluidic and Capillary Electrophoresis Applications
Authors: Taewoong Kim | Joo-Hee Oh | Seung Cheol Kim | Jong‐Guk Ahn | Soyoung Kim | Young Yong Kim | Hyunseob Lim
Source: Small Methods (article, 2024-05-09)
Field: Materials Science — Materials Chemistry

Photochemical and Patternable Synthesis of 2D Covalent Organic Framework Thin Film Using Dynamic Liquid/Solid Interface 2D covalent organic frameworks (COFs) are highly porous crystalline materials with promising applications in organic electronics. Current methods involve either on-surface synthesis (solid surface) or interfacial synthesis (liquid/liquid, liquid/gas interface) to create thin films for these applications, each with its drawbacks. On-surface synthesis can lead to contamination from COF powder or unreacted chemicals, while interfacial synthesis risks damaging the film during post-transfer processes. These challenges necessitate the development of alternative synthesis methods for high-quality 2D COF films. This study presents a novel approach for synthesizing homogeneous 2D COF thin films by combining photochemistry and a liquid-flowing system. Leveraging previous work on liquid flow systems to prevent contamination during solvothermal synthesis, this approach to the photochemical method, resulting in the synthesis of high-crystalline 2D COF films with tunable thickness is adopted. The photochemical approach offers spatially controllable energy sources, enabling patternable COF synthesis. Notably, it is successfully fabricated ultrasmooth patterned 2D COF films on hexagonal boron nitride, offering a streamlined process for optoelectronic device fabrication without additional pre, post-processing steps. Covalent bond ; Interface (matter) ; Materials science ; Thin film ; Photochemistry ; Chemical engineering ; Covalent organic framework ; Nanotechnology ; Optoelectronics ; Organic chemistry ; Chemistry ; Composite material Covalent Organic Framework Applications ; Metal-Organic Frameworks: Synthesis and Applications ; Advanced Photocatalysis Techniques
Authors: Alba Sanz-Velasco | Olivia Amargós‐Reyes | Aya Kähäri | Sophia Lipinski | Luca M. Cavinato | Rubén D. Costa | Mauri A. Kostiainen | Eduardo Anaya‐Plaza
Source: Chemical Science (article, 2024-01-01)
Field: Materials Science — Materials Chemistry

Controlling aggregation-induced emission by supramolecular interactions and colloidal stability in ionic emitters for light-emitting electrochemical cells Chromophores face applicability limitations due to their natural tendency to aggregate, with a subsequent deactivation of their emission features. Hence, there has been a fast development of aggregation induced emission (AIE) emitters, in which non-radiative motional deactivation is inhibited. However, a fine control of their colloidal properties governing the emitting performance is fundamental for their application in thin film optoelectronics. In addition, ion-based lighting devices, such as light emitting electrochemical cells (LECs), requires the design of ionic AIE emitters, whose structure allows (i) an easy ion polarizability to assist charge injection and (ii) a reversible electrochemical behavior. To date, these fundamental questions have not been addressed. Herein, the hydrophilic/hydrophobic balance of a family of cationic tetraphenyl ethene (TPE) derivatives is finely tuned by chemical design. The hydrophilic yet repulsive effect of pyridinium-based cationic moieties is balanced with hydrophobic variables (long alkyl chains or counterion chemistry), leading to (i) a control between monomeric/aggregate state ruling photoluminescence, (ii) redox behavior, and (iii) enhanced ion conductivity in thin films. This resulted in a LEC enhancement with the first ionic AIE emitters, reaching values of 0.19 lm W<sup>-1</sup> at <i>ca.</i> 50 cd m<sup>-2</sup>. Overall, this design rule will be key to advance ionic active species for optoelectronics. Supramolecular chemistry ; Electrochemistry ; Ionic bonding ; Aggregation-induced emission ; Colloid ; Chemistry ; Light emission ; Materials science ; Nanotechnology ; Chemical engineering ; Photochemistry ; Ion ; Optoelectronics ; Molecule ; Electrode ; Organic chemistry ; Physical chemistry ; Optics ; Physics ; Fluorescence Luminescence and Fluorescent Materials ; Molecular Sensors and Ion Detection ; Organic Light-Emitting Diodes Research
Authors: Xihao Chang | Jiayin Zhang | Xiang Cheng | Xianhai Lv | Chang Guo
Source: Advanced Science (article, 2024-07-25)
Field: Chemistry — Organic Chemistry

Ni/Cu Dual‐Catalyzed Propargylation for the Stereodivergent Synthesis of Methohexital The development of efficient methodologies for the controlled manufacture of specific stereoisomers bearing quaternary stereocenters has prompted advances in a variety of scientific disciplines including pharmaceutical chemistry, materials science, and chemical biology. However, complete control of the absolute and relative stereochemical configurations of alkyne derivatives remains an unmet synthetic challenge. Herein, a Ni/Cu dual-catalyzed asymmetric propargylic substitution reaction is presented to produce propargylated products with all-carbon quaternary stereocenters in high yields with significant diastereo- and enantioselectivities (up to >20:1 dr, >99% ee). The synthesis of all stereochemical variants of methohexital, a widely used sedative-hypnotic drug, exemplifies the efficacy of dual-catalyzed stereodivergent propargylation. Stereocenter ; Methohexital ; Catalysis ; Combinatorial chemistry ; Sedative/hypnotic ; Chemistry ; Alkyne ; Dual (grammatical number) ; Enantioselective synthesis ; Organic chemistry ; Sedative ; Medicine ; Pharmacology Catalytic Alkyne Reactions ; Asymmetric Synthesis and Catalysis ; Catalytic C–H Functionalization Methods
Authors: Davide Cademartori | Maxime Hubert | Peter Cloetens | Maria Paola Carpanese | Jérôme Laurencin
Source: Materials & Design (article, 2024-01-21)
Field: Materials Science — Materials Chemistry

The design optimization of nanostructured hierarchical electrodes for solid oxide cells by artificial impregnation Microstructural correlations of impregnated freeze tape cast scaffolds for solid oxide cells are studied by coupling experimental and modelling approaches. The functional and supporting layers of the hierarchical porous backbones are initially reconstructed by synchrotron X-ray micro- and nano-holotomography, respectively. A particle-based model was then built to numerically infiltrate the scaffold walls with hemispherical nanoparticles. The electrode microstructural properties are evaluated on the artificially impregnated electrodes as function of the catalyst loading. A parametric investigation on the effect of the nanoparticle size is performed to analyse the evolution of the electrode characteristics. It has been shown that the volume fraction of the infiltrated phase necessary to reach the percolating threshold is increased while increasing the nanoparticle size. The density of active sites presents a maximum as function of the catalyst loading that depends on the particle size. The volume fraction of infiltrated phase required to reach the percolating threshold in the diffusion layer is one order of magnitude lower than in the functional layer (∼1 vol% compared to 3–8 vol%, respectively). The analyses contained in this paper aim at guiding the manufacturing process to the shaping of innovative electrodes microstructures combining both high activation and mass transfer properties. Materials science ; Volume fraction ; Electrode ; Nanoparticle ; Porosity ; Microstructure ; Particle (ecology) ; Composite material ; Particle size ; Synchrotron ; Oxide ; Diffusion ; Phase (matter) ; Layer (electronics) ; Chemical engineering ; Nanotechnology ; Metallurgy Advancements in Solid Oxide Fuel Cells ; Catalytic Processes in Materials Science ; Electronic and Structural Properties of Oxides
Authors: Juan S. Serrano‐García | Andrés Amaya‐Flórez | Jordi R.‐Galindo | Lucero González‐Sebastián | Luis Humberto Delgado-Rangel | David Morales‐Morales
Source: Inorganics (article, 2024-08-15)
Field: Chemistry — Organic Chemistry

C–H Activation via Group 8–10 Pincer Complexes: A Mechanistic Approach C–H bond activation is a crucial synthetic strategy widely utilized in both academic and industrial settings. Due to the strong and kinetically inert nature of the C–H bond, its functionalization typically requires metal-based catalysts. This review highlights the most significant advancements in homogeneously catalyzed reactions using pincer complexes with metals from groups 8–10, capable of promoting challenging C–H activation, published since 2010. In particular, it focuses on C–H bond activation for borylation, isomerization, and dehydrogenation, among other processes, discussing their scope and mechanistic insights. Pincer movement ; Borylation ; Dehydrogenation ; Isomerization ; Catalysis ; Chemistry ; Combinatorial chemistry ; Scope (computer science) ; Surface modification ; Organic chemistry ; Computer science ; Physical chemistry Catalytic C–H Functionalization Methods ; Catalytic Cross-Coupling Reactions ; Asymmetric Hydrogenation and Catalysis
Authors: Elke De Zitter | David Perl | Martin Savko | Daniel W. Paley⧓ | Alexander J. R. Thom | Damien Jeangerard | Aaron S. Brewster | Antoine Tissot | Christian Serre | W. Steve Shepard
Source: CrystEngComm (article, 2024-01-01)
Field: Chemistry — Inorganic Chemistry

Elucidating metal–organic framework structures using synchrotron serial crystallography Metal organic frameworks (MOFs) are porous crystalline materials that display a wide variety of physical and chemical properties. Synchrotron ; Materials science ; Variety (cybernetics) ; Metal-organic framework ; Metal ; Porosity ; Crystallography ; Nanotechnology ; Chemistry ; Computer science ; Optics ; Metallurgy ; Physical chemistry ; Physics Metal-Organic Frameworks: Synthesis and Applications ; X-ray Diffraction in Crystallography ; Machine Learning in Materials Science
Authors: En Ma | Shiqi Yu | Wenwu You | Datao Tu | F.S. Wen | Yun Xing | Shan Lu | Xueyuan Chen
Source: The Journal of Chemical Physics (article, 2024-05-28)
Field: Materials Science — Materials Chemistry

Dynamic modulation of multicolor upconversion luminescence of Er3+ via excitation pulse width Lanthanide-doped upconversion (UC) luminescent materials display multicolor emissions, making them ideal for a variety of applications, such as multi-channel biological imaging, fluorescence encryption, anti-counterfeiting, and 3D display. Manipulating the UC emissions of the luminescent materials with a fixed composition is crucial for their applications. Herein, we propose a facile strategy to achieve pulse-width-dependent multicolor UC emissions in NaYF4:Yb/Er/Tm nanocrystals. Upon excitation with a 980 nm continuous-wave laser diode, Er3+ ions in NaYF4:20%Yb,15%Er,1%Tm nanocrystals exhibited UC emissions with a red-to-green (R/G) ratio of 11.3. Nevertheless, by employing a 980 nm pulse laser with pulse widths from 0.1 to 10 ms, the UC R/G ratio can be easily adjusted from 0.9 to 11.3, resulting in continuous and remarkable color transformation from green, yellow, orange, to red. By virtue of the dynamic luminescence color variation of these NaYF4:20%Yb,15%Er,1%Tm nanocrystals, we demonstrated their potential applications in the areas of anti-counterfeiting and information encryption. These findings provide deep insights into the excited-state dynamics and energy transfer of Er3+ in NaYF4:Yb/Er/Tm nanocrystals upon 980 nm pulse excitation, which may pave the way for designing multicolor UC materials toward versatile applications. Photon upconversion ; Luminescence ; Materials science ; Excitation ; Nanocrystal ; Laser ; Excited state ; Fluorescence ; Luminescent Measurements ; Ion ; Optoelectronics ; Energy transfer ; Pulse (music) ; Nanotechnology ; Optics ; Chemistry ; Atomic physics ; Physics Luminescence Properties of Advanced Materials ; Solid State Laser Technologies ; Glass properties and applications
Authors: Anastasiia Vasylaki | Pratyusha Ghosh | Edgar A. Jaimes | Ryan M. Williams
Source: Kidney360 (article, 2024-02-28)
Field: Materials Science — Biomaterials

Targeting the Kidneys at the Nanoscale: Nanotechnology in Nephrology Kidney diseases, both acute and chronic, are a substantial burden on individual and public health, and they continue to increase in frequency. Despite this and an intense focus on the study of disease mechanisms, few new therapeutic approaches have extended to the clinic. This is in part due to poor pharmacology of many, if not most, therapeutics with respect to the sites of kidney disease within the glomerulus or nephron. Considering this, within the past decade, and more pointedly over the past 2 years, there have been substantial developments in nanoparticle systems to deliver therapeutics to the sites of kidney disease. Here, we provide a broad overview of the various classes of nanomaterials that have been developed to improve therapeutic development for kidney diseases, the strategy used to provide kidney accumulation, and briefly the disease models they focused on, if any. We then focus on one specific system, polymeric mesoscale nanoparticles, which has broadly been used over 13 publications, demonstrating targeting of the tubular epithelium with 26-fold specificity compared with other organs. While there have been several nanomedicines that have advanced to the clinic in the past several decades, including mRNA-based coronavirus disease vaccines and others, none have focused on kidney diseases specifically. In total, we are confident that the rapid advancement of nanoscale-based kidney targeting and a concerted focus by clinicians, scientists, engineers, and other stakeholders will push one or more of these technologies into clinical trials over the next decade. Nanotechnology ; Nephrology ; Nanoscopic scale ; Materials science ; Medicine ; Internal medicine Nanoparticle-Based Drug Delivery ; Graphene and Nanomaterials Applications ; Acute Kidney Injury Research
Authors: Ali Esrafili | Mahnaz Ghambarian | Mahmood Yousefi | Najmeh Yazdanfar
Source: Scientific Reports (article, 2024-12-28)
Field: Chemistry — Inorganic Chemistry

Efficient removal of uranium (VI) from environmental water samples by cyclodextrin-intercalated layered double hydroxide-coated magnetic nanoparticles This manuscript describes the successful synthesis of Fe<sub>3</sub>O<sub>4</sub> nanoparticles coated with β-cyclodextrin-intercalated layered double hydroxide, which were utilized to remove Uranium (VI) from an aqueous solution effectively. The newly developed nano-adsorbent underwent thorough analysis through advanced techniques such as scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM), and energy-dispersive X-ray analysis (EDX). Through the utilization of a one-variable-at-a-time strategy, we effectively enhanced the removal process by optimizing key factors such as the sample's pH and the amount of adsorbent utilized. These adjustments proved crucial in achieving utmost success. The adsorption mechanism was identified by plotting Langmuir and Freundlich isotherms. Under the optimized conditions, the removal efficiency of as high as 96.21%, as well as the adsorption capacity of 461.89 mg g<sup>- 1</sup>, were obtained showing the desirable performance of the synthesized nano-adsorbent in Uranium (VI) removal from aqueous solutions. The selectivity of the adsorbent was evaluated by calculating distribution coefficients for Uranium (VI) and some interfering ions. The applicability of the adsorbent was tested by removing uranium (VI) from diverse complex environmental water samples. As a result of the removal efficiencies exceeding 92.76% with relative standard deviations (RSDs%) below 6.73%, the synthesized adsorbent can successfully remove Uranium (VI) from complex real samples with acceptable precisions. Hydroxide ; Cyclodextrin ; Uranium ; Nanoparticle ; Magnetic nanoparticles ; Layered double hydroxides ; Nuclear chemistry ; Chemistry ; Chemical engineering ; Materials science ; Nanotechnology ; Inorganic chemistry ; Chromatography ; Metallurgy Radioactive element chemistry and processing ; Layered Double Hydroxides Synthesis and Applications ; Covalent Organic Framework Applications
Authors: Mahsa Amirrashedi | Andreas I. Jensen | Qing Tang | Natan J. W. Straathof | Katharina Ravn | Christian Pedersen | Louise Langhorn | Frantz Rom Poulsen | Max Woolley | David W. Johnson | Julia Williams | C. Kidd | Helge Thisgaard | Bo Halle
Source: ACS Nano (article, 2024-06-26)
Field: Materials Science — Biomaterials

The Influence of Size on the Intracranial Distribution of Biomedical Nanoparticles Administered by Convection-enhanced Delivery in Minipigs Because of the blood-brain barrier (BBB), successful drug delivery to the brain has long been a key objective for the medical community, calling for pioneering technologies to overcome this challenge. Convection-enhanced delivery (CED), a form of direct intraparenchymal microinfusion, shows promise but requires optimal infusate design and real-time distribution monitoring. The size of the infused substances appears to be especially critical, with current knowledge being limited. Herein, we examined the intracranial administration of polyethylene glycol (PEG)-coated nanoparticles (NPs) of various sizes using CED in groups of healthy minipigs (<i>n</i> = 3). We employed stealth liposomes (LIPs, 130 nm) and two gold nanoparticle designs (AuNPs) of different diameters (8 and 40 nm). All were labeled with copper-64 for quantitative and real-time monitoring of the infusion via positron emission tomography (PET). NPs were infused via two catheters inserted bilaterally in the putaminal regions of the animals. Our results suggest CED with NPs holds promise for precise brain drug delivery, with larger LIPs exhibiting superior distribution volumes and intracranial retention over smaller AuNPs. PET imaging alongside CED enabled dynamic visualization of the process, target coverage, timely detection of suboptimal infusion, and quantification of distribution volumes and concentration gradients. These findings may augment the therapeutic efficacy of the delivery procedure while mitigating unwarranted side effects associated with nonvisually monitored delivery approaches. This is of vital importance, especially for chronic intermittent infusions through implanted catheters, as this information enables informed decisions for modulating targeted infusion volumes on a catheter-by-catheter, patient-by-patient basis. Drug delivery ; Catheter ; Distribution (mathematics) ; Biomedical engineering ; Polyethylene glycol ; Medicine ; Positron emission tomography ; Nanoparticle ; Nanotechnology ; Materials science ; Pharmacology ; Nuclear medicine ; Radiology ; Chemistry Nanoparticle-Based Drug Delivery ; Gold and Silver Nanoparticles Synthesis and Applications ; RNA Interference and Gene Delivery
Authors: Dimitrios Marinis | Dionysios Markatos | Ergina Farsari | E. Amanatides | D. Mataras | Spiros Pantelakis
Source: Polymers (article, 2024-10-07)
Field: Materials Science — Materials Chemistry

A Novel Plasma-Enhanced Solvolysis as Alternative for Recycling Composites In this work, a plasma-assisted solvolysis method is proposed as an alternative method for the oxidative degradation of carbon fiber-reinforced composites (CFRCs). Nitrogen plasma ignition within bubbles in a concentrated nitric acid solution is employed, combining the synergistic effects of traditional nitric acid solvolysis and plasma chemistry. A comprehensive process flowchart, including steps such as composite pretreatment, matrix dissolution, fiber recovery and cleaning, solvent regeneration and reuse, and waste treatment, is also discussed, highlighting their importance in process effectiveness. Moreover, a study on the effect of the composite's mass on the plasma-enhanced solvolysis process is conducted, and the results are exploited for the calculation of critical parameters such as efficiency, recovery rates, capacity, fibers quality, energy consumption, consumption of raw materials, operational and installation costs, and environmental impact. A preliminary comparison to other recycling methods based on the literature findings is also attempted, and preliminary metrics to assess the sustainability of the recycling process are proposed. Solvolysis ; Nitric acid ; Composite number ; Fiber ; Pulp and paper industry ; Materials science ; Process engineering ; Chemical engineering ; Chemistry ; Composite material ; Waste management ; Organic chemistry ; Hydrolysis Graphene research and applications ; Fiber-reinforced polymer composites ; Surface Modification and Superhydrophobicity