jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Benjamin L. L. Réant | John A. Seed | George F. S. Whitehead | Conrad A. P. Goodwin
Source: Inorganic Chemistry (article, 2025-02-07)
Field: Chemistry — Inorganic Chemistry

Uranium(III) and Uranium(IV) <i>meta</i>-Terphenylthiolate Complexes We report the synthesis and characterization of crystalline <i>m</i>-terphenylthiolate uranium complexes supported by the bulky ligand system, SAr<sup><i>i</i>Pr6</sup> (SAr<sup><i>i</i>Pr6</sup> = {SC<sub>6</sub>H<sub>3</sub>-2,6-(Tripp)<sub>2</sub>}; Tripp = 2,4,6-<i>i</i>Pr-C<sub>6</sub>H<sub>2</sub>). Treatment of U<sup>IV</sup>Cl<sub>4</sub> with 2 equiv of KSAr<sup><i>i</i>Pr6</sup> in Et<sub>2</sub>O afforded both [U<sup>IV</sup>(SAr<sup><i>i</i>Pr6</sup>)<sub>2</sub>(Cl)<sub>2</sub>] (<b>1</b>) and the Et<sub>2</sub>O adduct, [U<sup>IV</sup>(SAr<sup><i>i</i>Pr6</sup>)<sub>2</sub>(Cl)<sub>2</sub>(Et<sub>2</sub>O)<sub>2</sub>] (<b>1·Et</b><sub><b>2</b></sub><b>O</b>) in poor yield. The reaction between [U<sup>IV</sup>(BH<sub>4</sub>)<sub>4</sub>] and 1 equiv of KSAr<sup><i>i</i>Pr6</sup> in toluene gave several crystals of the double salt, [U<sup>IV</sup>(μ-SAr<sup><i>i</i>Pr6</sup>)(BH<sub>4</sub>)<sub>2</sub>(μ-BH<sub>4</sub>)(μ<sup>3</sup>-BH<sub>4</sub>)K]<sub>2</sub> (<b>2</b>), and exposing the crude reaction mixture to Et<sub>2</sub>O gave the disulfide dimer, (SAr<sup><i>i</i>Pr6</sup>)<sub>2</sub>. The reaction between [U<sup>IV</sup>(BH<sub>4</sub>)<sub>4</sub>] and 1 equiv of HSAr<sup><i>i</i>Pr6</sup> in hot toluene gave [U<sup>III</sup>(H<sub>3</sub>B·SAr<sup><i>i</i>Pr6</sup> κ<i>S</i>,<i>H</i>,<i>H</i>)(BH<sub>4</sub>)<sub>2</sub>] (<b>3</b>) which proved resistant to further substitution using either HSAr<sup><i>i</i>Pr6</sup> or KSAr<sup><i>i</i>Pr6</sup>. Two U(III) <i>mono</i>-terphenylthiolates, [U<sup>III</sup>(SAr<sup><i>i</i>Pr6</sup>)(BH<sub>4</sub>)<sub>2</sub>] (<b>4a</b>) and [{U<sup>III</sup>(SAr<sup><i>i</i>Pr6</sup>)(BH<sub>4</sub>)}<sub>2</sub>{μ-B<sub>2</sub>H<sub>6</sub>}] (<b>4b</b>), were isolated as a mixture from the reaction between [U<sup>III</sup>(BH<sub>3</sub>)<sub>3</sub>(toluene)] and 1 equiv of KSAr<sup><i>i</i>Pr6</sup>, while using 2 equiv of KSAr<sup><i>i</i>Pr6</sup> gave the <i>bis</i>-terphenylthiolate complex [U<sup>III</sup>(SAr<sup><i>i</i>Pr6</sup>)<sub>2</sub>(BH<sub>4</sub>)] (<b>5</b>). Complex <b>4b</b> is a rare example of a <i>nido</i>-metalloborane. Complexes <b>1</b>-<b>5</b> have been characterized variously by single-crystal and powder X-ray diffraction, multinuclear NMR spectroscopy, infrared spectroscopy, UV-Vis-NIR spectroscopy, SQUID magnetometry, and elemental analyses as appropriate. Quantum chemical calculations have been employed to interpret the nature of the U-S bonding interactions across these complexes. Chemistry ; Uranium ; Radiochemistry ; Nuclear chemistry ; Metallurgy Radioactive element chemistry and processing ; Chemical Thermodynamics and Molecular Structure ; Lanthanide and Transition Metal Complexes
Authors: Franciela Arenhart Soares | Pol Besenius
Source: Organic Chemistry Frontiers (article, 2025-01-01)
Field: Materials Science — Biomaterials

Mechanophoric hydrogels: when mechanical stress produces useful responses Mechanophoric hydrogels undergo visible color changes or alterations in optical properties in response to mechanical stimuli. Chemistry ; Self-healing hydrogels ; Stress (linguistics) ; Polymer chemistry Silk-based biomaterials and applications
Authors: Davy Guillarme | Szabolcs Fekete | Sylwia Studzińska
Source: Journal of Separation Science (article, 2025-01-01)
Field: Chemistry — Spectroscopy

Protocol for Oligonucleotides Characterization Using Hydrophilic Interaction Chromatography Oligonucleotides (ONs) are an increasingly popular category of molecules in the pharmaceutical landscape, particularly attractive for the treatment of genetic and rare diseases. However, analyzing these molecules presents significant challenges, due to their highly hydrophilic nature, multiple negative charges, and the presence of closely related impurities resulting from the complex solid-phase synthesis process. Ion pairing reverse-phase liquid chromatography (IP-RPLC) is the preferred technique for ONs analysis but is not ideal for mass spectrometry (MS) coupling. Consequently, there is a growing interest in exploring alternative strategies with hydrophilic interaction chromatography (HILIC) emerging as one of the most promising options. As HILIC is not yet fully established for the analysis of ONs, we have prepared this protocol paper to facilitate entry into this field. It not only provides best practices, opportunities, and potential advantages but also caveats and other important considerations for using HILIC to characterize ONs. The paper addresses the selection of stationary and mobile phases, optimization of gradient conditions, MS coupling, and key aspects to consider when manipulating ON samples. We hope this protocol will help establish HILIC as a more universal solution for ONs analysis. Hydrophilic interaction chromatography ; Chemistry ; Protocol (science) ; Oligonucleotide ; Chromatography ; Reversed-phase chromatography ; Combinatorial chemistry ; High-performance liquid chromatography Analytical Chemistry and Chromatography ; Chromatography in Natural Products ; Metabolomics and Mass Spectrometry Studies
Authors: Mehrab Pourmadadi | Mahdi Maleki | Abbas Rahdar | M. Ali Aboudzadeh
Source: Journal of Nanoparticle Research (article, 2025-06-01)
Field: Materials Science — Biomaterials

Innovative polymeric and non-polymeric nanocarrier systems for dexamethasone: enhancing precision and reducing side effects Abstract Dexamethasone (DEX), a potent synthetic glucocorticoid, has long been recognized for its remarkable anti-inflammatory, immunosuppressive, and therapeutic potential across diverse medical domains. However, traditional delivery methods have been hindered by systemic toxicity, poor targeting, and limited efficacy. This comprehensive review explores cutting-edge drug delivery technologies that are revolutionizing DEX’s therapeutic landscape, offering unprecedented precision and enhanced clinical outcomes. The review systematically examines advanced carrier systems, including lipid-based nanoparticles, micelles, polymeric nanoparticles, cyclodextrin-based platforms, hyaluronic acid nanocarriers, hydrogels, carbon-based nanostructures, and inorganic nanostructures. These innovative approaches demonstrate remarkable capabilities in improving drug bioavailability, targeted delivery, sustained release, and minimized systemic side effects. Cutting-edge research highlights the transformative potential of these delivery systems across multiple therapeutic areas, including rheumatoid arthritis, inflammatory bowel disease, oncology, neurodegenerative disorders, bone regeneration, and ocular and respiratory treatments. By enhancing drug targeting, controlling release kinetics, and reducing adverse effects, these nanotechnology-driven platforms are poised to reshape DEX’s clinical applications, offering more precise and effective treatment strategies. Nanocarriers ; Materials science ; Nanotechnology ; Drug delivery Nanoparticle-Based Drug Delivery ; Advanced Drug Delivery Systems ; Nanoplatforms for cancer theranostics
Authors: Salim-Ramy Merouani | Roman Kulagin | V. S. Bondarenko | Ramin Hosseinnezhad | Fahmi Zaïri | Iurii Vozniak
Source: ACS Macro Letters (article, 2025-01-12)
Field: Materials Science — Polymers and Plastics

Strategy for Fabricating Multiple-Shape Memory Polymeric Materials Based on Solid State Mixing Traditionally, multiple shape memory polymers (multiple-SMPs) are created by forming either immiscible blends with high phase continuity (cocontinuous or multilayer phase morphology) or miscible blends that exhibit compositional heterogeneity at the nanoscale. Here, a new strategy for the fabrication of multiple-SMPs is proposed. It consists of the possibility of homogeneous mixing of immiscible polymers in the solid state under high pressure and shear deformation conditions. The blends formed in this way exhibit homogeneity of mixing down to the nanoscale, up to 40-95 nm. The transition from immiscible to miscible blends leads to an improvement not only in shape memory but also in the mechanical performance of the blends formed. Polypropylene (PP) and polystyrene (PS) were selected as pairs of immiscible polymers. The method of solid phase mixing is high pressure torsion (HPT). It was shown that the HPT-processed 50% PP/50% PS blend is able to exhibit an excellent triple shape memory effect (shape fixation of ∼94-95%, and recovery of ∼85-95%) with widely tunable (low and high) transition temperatures. Materials science ; Mixing (physics) ; Solid-state ; Shape-memory polymer ; Nanotechnology ; Composite material ; Chemical engineering ; Polymer ; Chemistry ; Physical chemistry Polymer composites and self-healing ; Photopolymerization techniques and applications ; Advanced Polymer Synthesis and Characterization
Authors: Rasool Shabanloo | Majid Montazer | Ali Farahani | Nesa Karimi
Source: Heliyon (review, 2025-01-01)
Field: Materials Science — Biomaterials

RETRACTED: A review on surface modification of nanofibrous textiles for diverse applications: Focus on medical uses Electrospun nanofibers with a high surface area are attractive materials for biomedical applications. They have potential use in scaffolds, drug delivery, bio face masks, wound dressings, and biosensors. Various surface modifications have been developed to improve their chemical and physical properties. These modifications include physical, chemical, biological, and nano-treatment approaches. The physical modification includes annealing, stretching, and plasma treatment. Chemical modification includes functionalization with chemical groups, while biological modification involves coating with proteins, enzymes, or antibodies. Nanotreatment approaches use nanomaterials to modify the surface of nanofibers. These modifications enhance the characteristics of the biomedical nanofibers, making them more effective and efficient for their intended applications. The review summarizes the latest research on electrospun nanofiber modification procedures, strategies, and utilities for various biomedical applications. It provides insights into the conditions and requirements of each modification approach and their effects on the properties of the nanofibers. Moreover, it emphasizes the importance of functionalizing nanofibers to meet the most important specific requirements and the potential of electrospun nanofibers in various biomedical applications. Focus (optics) ; Nanotechnology ; Nanofiber ; Surface modification ; Polymer science ; Electrospinning ; Materials science ; Engineering ethics ; Engineering ; Composite material ; Chemical engineering ; Physics ; Polymer ; Optics Electrospun Nanofibers in Biomedical Applications ; Advanced Sensor and Energy Harvesting Materials ; Polymer Nanocomposite Synthesis and Irradiation
Authors: Elisa Chakraborty | R. Weiss
Source: Chemical Society Reviews (review, 2025-01-01)
Field: Chemistry — Inorganic Chemistry

Organoantimony: a versatile main-group platform for pnictogen-bonding and redox catalysis The chemistry of main-group elements has seen remarkable advances in organic synthesis and catalysis, redefining the boundaries of redox and acid-base reactivity traditionally dominated by transition metals. Among these developments, organoantimony chemistry has remained largely overlooked. Yet, recent discoveries have unveiled its multifaceted reactivity, spanning redox processes and Lewis acidity through the so-called pnictogen bond, positioning it as a promising underexplored platform for organic synthesis and catalysis. This Tutorial Review delves into the fundamental principles underlying organoantimony reactivity, drawing comparisons with other main-group elements while highlighting its distinctive behaviour. We examine its emerging roles in non-covalent interactions, organometallic transformations, and redox catalysis, offering a comprehensive perspective on its synthetic potential. Pnictogen ; Redox ; Reactivity (psychology) ; Oxidation reduction ; Organic synthesis ; Catalysis Synthesis and characterization of novel inorganic/organometallic compounds ; Organoboron and organosilicon chemistry ; Organometallic Complex Synthesis and Catalysis
Authors: L. Linke | Katharina E. Dehm | Kirill Gubanov | R. Fink | Bartłomiej M. Szyja | Ryan W. Crisp
Source: Nanoscale (article, 2025-01-01)
Field: Materials Science — Polymers and Plastics

Colloidal organometallic synthesis of solution-processable barium titanate nanoparticles for nanoelectronic applications Perovskite oxides like barium titanate (BaTiO<sub>3</sub>) exhibit desirable properties: notably high dielectric constants, piezoelectricity, and ferroelectricity, thereby enabling more advanced electronic devices and actuators. There are numerous synthesis procedures for BaTiO<sub>3</sub>, among which, nanoparticle syntheses are versatile and well-studied. However, colloidal organometallic synthesis is less commonly employed for this material despite offering processing advantages like facile compositional control and customizable surface chemistry. Here, an organometallic synthesis route is explored to produce colloidally stable BaTiO<sub>3</sub> nanoparticles with oleyl alkoxide ligands. Subsequently, we further develop ligand exchange procedures with X-type ligands using KOH and oxalic acid to produce colloidal inks applicable for solution-processed nanocrystalline films for dielectrics in devices for which there is still a need for better nanoscale control. The BaTiO<sub>3</sub> nanoparticles and films were characterized using X-ray diffraction (XRD), scanning transmission electron microscopy (STEM), energy-dispersive X-ray spectroscopy (EDS), Fourier-transform infrared spectroscopy (FT-IR), atomic force microscopy (AFM), Kelvin probe force microscopy (KPFM), and density functional theory (DFT), to understand their properties and to develop processes for device applications. Barium titanate ; Materials science ; Nanoparticle ; Nanotechnology ; Colloid ; Chemical engineering ; Ceramic ; Metallurgy ; Engineering Dendrimers and Hyperbranched Polymers ; Nanomaterials for catalytic reactions ; Polyoxometalates: Synthesis and Applications
Authors: Aashutosh Dube | Shweta J. Malode | Maha Alruwaili | Abdullah N. Alodhayb | T. Maiyalagan | Nagaraj P. Shetti
Source: ChemElectroChem (article, 2025-04-28)
Field: Materials Science — Materials Chemistry

Borophene and Its Composite‐Based Electrochemical Sensors Borophene is found as a monolayer of boron. It emerges as a promising 2D nanomaterial with unique characteristics like anisotropic metallic nature and direction‐dependent mechanical and optical properties. High electrical conductivity, surface corrugation, high chemical reactivity, and substantially high electron mobility are the unique properties of borophene that are relevant to electrochemical sensor applications. This study encapsulates advancements in borophene‐based electrochemical sensors and biosensors for sensing analytes, including glucose, urea, dopamine, and arsenic toxicity in water. A succinct summary has been presented, including all significant sensor attributes, the determined limit of detection, established linear dynamic range, utilized analytical approach, and documented sensor stability. The stability concerns have been mitigated by surface passivation and encapsulation, whereas real‐time applications can be advanced by collaborating with industries, developing devices, and conducting pilot tests. The article delineates the process's constraints and problems while proposing alternative techniques and remedies. Borophene ; Composite number ; Electrochemistry ; Materials science ; Composite material ; Nanotechnology ; Chemistry ; Electrode ; Graphene Boron and Carbon Nanomaterials Research ; MXene and MAX Phase Materials ; Boron Compounds in Chemistry
Authors: Dolores Hidalgo | Lidia Garrote | F. Infante | Jesús M. Martín-Marroquín | Enrique Pérez-Zapatero | Francisco Corona
Source: Applied Sciences (article, 2025-05-24)
Field: Materials Science — Biomaterials

Targeted Acidogenic Fermentation of Waste Streams for the Selective Production of Volatile Fatty Acids as Bioplastic Precursors The sustainable production of bioplastics is increasingly important for reducing reliance on fossil fuels and addressing environmental challenges. The acidogenic fermentation of waste streams offers a promising pathway for generating key bioplastic precursors, such as volatile fatty acids, which can be used to produce polymers like polyhydroxyalkanoates. This review explores the potential of various waste streams, including agricultural residues, industrial by-products, and food waste, as substrates for acidogenic fermentation, aligning with circular economy principles by reducing waste and environmental impact. A key feature of this review is its focus on targeted acidogenic fermentation, which optimizes process conditions to maximize the production of specific acids based on waste characteristics. The analysis emphasizes how the chemical composition and biodegradability of waste streams influence the selection of microbial consortia and metabolic pathways, determining the yield and composition of the products generated. The review also highlights the adaptability of acidogenic fermentation to heterogeneous and variable waste streams, underlining its potential as a scalable and sustainable solution for bioplastic precursor production. By tailoring process parameters such as pH and hydraulic retention time to the specific characteristics of the substrate, targeted acidogenic fermentation can effectively transform waste into high-value intermediates. Finally, challenges related to the scalability and economic feasibility of these processes are discussed, along with opportunities for integrating acidogenic fermentation with complementary waste valorization technologies to advance the bio-based economy. The findings underscore the critical role of waste streams in enabling the sustainable and efficient generation of bioplastic precursors, contributing to a circular economy framework. Bioplastic ; Acidogenesis ; Waste management ; Dark fermentation ; Food waste ; Biochemical engineering ; Environmental science ; Anaerobic digestion ; Chemistry ; Biohydrogen ; Engineering ; Biochemistry biodegradable polymer synthesis and properties ; Enzyme Catalysis and Immobilization ; Enzyme Production and Characterization
Authors: Hao Liang | James P. Morken
Source: Journal of the American Chemical Society (article, 2025-04-09)
Field: Chemistry — Organic Chemistry

Direct Observation of Alkyl Group Transmetalation from Boron to Copper: Impact of Structure Modification and the Critical Role of Copper–Oxygen Preassociation in Stereospecificity Mechanistic investigations of prospective intermediates in copper-catalyzed cross-coupling reactions with alkyllithium-activated alkylboronic esters are described. Complexes between (NHC)copper and the borate salts were characterized by X-ray crystallography and NMR, and the rate of intramolecular transmetalation of an alkyl group from boron to copper was measured. Derived activation parameters were correlated with those determined by DFT analysis and give insight into the mechanism of stereospecific transmetalation. Transmetalation ; Chemistry ; Copper ; Alkyl ; Boron ; Stereospecificity ; Oxygen ; Group (periodic table) ; Polymer chemistry ; Inorganic chemistry ; Organic chemistry ; Catalysis Organoboron and organosilicon chemistry ; Coordination Chemistry and Organometallics ; Organometallic Complex Synthesis and Catalysis
Authors: Clément Diguet | Amparo Navarro | M. Paz Fernández‐Liencres | Sonia B. Jiménez‐Pulido | Nuria A. Illán‐Cabeza | Julien Massue | Sébastien Gauthier | Françoise Robin‐Le Guen | Sylvain Achelle | Julián Rodríguez‐López
Source: Dyes and Pigments (article, 2025-01-20)
Field: Materials Science — Materials Chemistry

Synthesis and photophysical properties of 6-aryl-2,4-bis(2′-hydroxyphenyl)pyrimidines ligands and their boron fluoride complexes A new family of 6-aryl-2,4-bis(2′-hydroxyphenyl)pyrimidines has been efficiently synthesized and characterized using Suzuki-Miyaura reactions, demonstrating their ability to function as rigid tridentate O^N^O chelating ligands for the preparation of four-coordinate organoboron compounds. Similar to related structures, the uncoordinated compounds do not exhibit fluorescence in either solution or the solid state. The intramolecular hydrogen bonds in their molecular structure promote an excited-state intramolecular proton transfer (ESIPT) process, leading to an excited keto tautomer that deactivates through non-radiative decay. Protonation and boron complexation can successfully inhibit the ESIPT process, resulting in fluorescence recovery, which can be finely tuned by modifying the substituents on the aryl group. Advanced techniques, including X-ray diffraction, density functional theory (DFT), and time-dependent DFT (TD-DFT), provide critical insights into the electronic structure and emission properties. This work offers a deeper understanding of the role of boron chelation in modulating emission properties, opening new avenues for the design of functional fluorescent materials. 6-Aryl-2,4-bis(2′-hydroxyphenyl)pyrimidines act as efficient tridentate O^N^O ligands in four-coordinate organoboron complexes, restoring fluorescence that can be finely tuned by modifying the aryl substituents. • A series of 6-aryl-2,4-bis(2′-hydroxyphenyl)pyrimidine chromophores were designed. • These chromophores are not luminescent due to ESIPT phenomenon. • The protonated forms are luminescent due to inhibition of ESIPT. • Boron fluoride complexes are highly emissive. Aryl ; Fluoride ; Boron ; Chemistry ; Photochemistry ; Polymer chemistry ; Organic chemistry ; Inorganic chemistry Luminescence and Fluorescent Materials ; Organic Light-Emitting Diodes Research ; Photochemistry and Electron Transfer Studies
Authors: Lihong Zhou | Jingyu Yan | Chenying Cui | Yurong Xu | Kaifang Zhang | Meijun Du | Zhuowei Zhang | Xiuping Wu | Bing Li
Source: Small Structures (article, 2025-06-25)
Field: Materials Science — Materials Chemistry

Nanozymes in Reactive Oxygen Species‐Dependent Diseases: From Design and Preclinical Studies to Clinical Translation Prospects Reactive oxygen species (ROS) imbalance is a key pathological factor in various diseases. Traditional biocatalytic agents, while effective to some extent, are limited by low catalytic efficiency, poor stability, immunogenicity, and lack of specificity. Recent advances in ROS‐dependent diseases have shifted the focus to leveraging nanozymes for therapy. Nanozymes demonstrate superior stability, tunability, enzymatic mimicry, and targeting capabilities, offering unprecedented therapeutic advantages and transformative potential in precision medicine. This review summarizes recent research progress of nanozymes in ROS‐dependent disease therapy; explores their mechanisms of action, including promoting and scavenging ROS; and discusses design strategies, such as replicating natural enzyme structures and catalytic active sites, as well as designing responsive mechanisms. The review also highlights recent clinical progress of nanozymes in treating ROS‐dependent diseases and delves into the opportunities and challenges in nanozyme development. It aims to provide insights for researchers in nanozyme and nanomedicine fields, promoting nanozyme applications, enhancing clinical management of ROS‐related diseases, and fostering integration of nanotechnology with medical sciences. Reactive oxygen species ; Translation (biology) ; Computational biology ; Chemistry ; Neuroscience ; Medicine ; Biology ; Biochemistry Advanced Nanomaterials in Catalysis ; Advanced biosensing and bioanalysis techniques ; Electrochemical sensors and biosensors