jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Qian Lin | Xiaolong Ding | Yuan-Sheng Hou | Wajahat Ali | Zichen Li | Xinya Han | Zhen Meng | Yue Sun | Yi Liu
Source: Eco-Environment & Health (review, 2024-03-04)
Field: Chemistry — Inorganic Chemistry

Adsorption and separation technologies based on supramolecular macrocycles for water treatment The escalating challenges in water treatment, exacerbated by climate change, have catalyzed the emergence of innovative solutions. Novel adsorption separation and membrane filtration methodologies, achieved through molecular structure manipulation, are gaining traction in the environmental and energy sectors. Separation technologies, integral to both the chemical industry and everyday life, encompass concentration and purification processes. Macrocycles, recognized as porous materials, have been prevalent in water treatment due to their inherent benefits: stability, adaptability, and facile modification. These structures typically exhibit high selectivity and reversibility for specific ions or molecules, enhancing their efficacy in water purification processes. The progression of purification methods utilizing macrocyclic frameworks holds promise for improved adsorption separations, membrane filtrations, resource utilization, and broader water treatment applications. This review encapsulates the latest breakthroughs in macrocyclic host-guest chemistry, with a focus on adsorptive and membrane separations. The aim is to spotlight strategies for optimizing macrocycle designs and their subsequent implementation in environmental and energy endeavors, including desalination, elemental extraction, seawater energy harnessing, and sustainable extraction. Hopefully, this review can guide the design and functionality of macrocycles, offering a significantly promising pathway for pollutant removal and resource utilization. Adsorption ; Water treatment ; Membrane ; Nanotechnology ; Portable water purification ; Desalination ; Chemistry ; Materials science ; Biochemical engineering ; Process engineering ; Chemical engineering ; Environmental science ; Organic chemistry ; Engineering ; Environmental engineering Metal-Organic Frameworks: Synthesis and Applications ; Covalent Organic Framework Applications ; Supramolecular Chemistry and Complexes
Authors: Haonian Shu | Pengyu Chen | Rong Yang
Source: Chem & Bio Engineering (review, 2024-06-14)
Field: Chemistry — Organic Chemistry

Advances in Antibacterial Polymer Coatings Synthesized via Chemical Vapor Deposition Biofouling is a major issue across various industries ranging from healthcare to the production of food and water and transportation. Biofouling is often induced or mediated by environmental microbes, such as bacteria. Therefore, developing antibacterial coatings has been an essential focus of recent research on functional polymer thin films. To achieve high film quality, vapor-phase techniques represent promising alternatives to traditional solution-based methods, especially for the design and synthesis of antibacterial polymer coatings, as they enable highly uniform, chemically precise, and substrate-independent coatings. This Perspective examines the potential of vapor-phase polymerization techniques to create novel antibacterial polymer coatings. Current advancements in the design of antifouling, bactericidal, antibiofilm, and multifunctional coatings via vapor-phase techniques are organized based on their action mechanisms and design principles. The opportunities and challenges associated with implementing vapor-phase polymerization for developing antibacterial coatings are highlighted. Biofouling ; Materials science ; Nanotechnology ; Polymerization ; Polymer ; Chemical vapor deposition ; Vapor phase ; Chemical engineering ; Chemistry ; Composite material ; Engineering Antimicrobial agents and applications ; Marine Biology and Environmental Chemistry ; Polymer Surface Interaction Studies
Authors: Mohamed Abdel‐Hamid | Mi‐Ran Ki | Seung Pil Pack
Source: International Journal of Molecular Sciences (article, 2024-04-25)
Field: Materials Science — Biomaterials

Biominerals and Bioinspired Materials in Biosensing: Recent Advancements and Applications Inspired by nature's remarkable ability to form intricate minerals, researchers have unlocked transformative strategies for creating next-generation biosensors with exceptional sensitivity, selectivity, and biocompatibility. By mimicking how organisms orchestrate mineral growth, biomimetic and bioinspired materials are significantly impacting biosensor design. Engineered bioinspired materials offer distinct advantages over their natural counterparts, boasting superior tunability, precise controllability, and the ability to integrate specific functionalities for enhanced sensing capabilities. This remarkable versatility enables the construction of various biosensing platforms, including optical sensors, electrochemical sensors, magnetic biosensors, and nucleic acid detection platforms, for diverse applications. Additionally, bioinspired materials facilitate the development of smartphone-assisted biosensing platforms, offering user-friendly and portable diagnostic tools for point-of-care applications. This review comprehensively explores the utilization of naturally occurring and engineered biominerals and materials for diverse biosensing applications. We highlight the fabrication and design strategies that tailor their functionalities to address specific biosensing needs. This in-depth exploration underscores the transformative potential of biominerals and materials in revolutionizing biosensing, paving the way for advancements in healthcare, environmental monitoring, and other critical fields. Biosensor ; Nanotechnology ; Biomimetic materials ; Computer science ; Materials science Diatoms and Algae Research ; Advanced biosensing and bioanalysis techniques ; Analytical Chemistry and Sensors
Authors: Ki Hyun Nam
Source: Current Research in Structural Biology (review, 2024-01-01)
Field: Materials Science — Materials Chemistry

Guide to serial synchrotron crystallography Serial crystallography (SX) is an emerging technique that can be used to determine the noncryogenic crystal structure of macromolecules while minimizing radiation damage. Applying SX using pump-probe or mix-and-inject techniques enables the observation of time-resolved molecular reactions and dynamics in macromolecules. After the successful demonstration of the SX experimental technique with structure determination in serial femtosecond crystallography using an X-ray free electron laser, this method was adapted to the synchrotron, leading to the development of serial synchrotron crystallography (SSX). SSX offers new opportunities for researchers to leverage SX techniques, contributing to the advancement of structural biology and offering a deeper understanding of the structure and function of macromolecules. This review covers the background and advantages of SSX and its experimental approach. It also discusses important considerations when conducting SSX experiments. Synchrotron ; Femtosecond ; Synchrotron radiation ; Macromolecule ; Laser ; Electron crystallography ; Materials science ; Crystallography ; Nanotechnology ; Optics ; Chemistry ; Diffraction ; Electron diffraction ; Physics Enzyme Structure and Function ; Porphyrin Metabolism and Disorders ; Protein Structure and Dynamics
Authors: Christopher M. Green | Deborah Sementa | Divita Mathur | Joseph S. Melinger | Priyasha Deshpande | Shana Elbaum‐Garfinkle | Igor L. Medintz | Rein V. Ulijn | Sebastián A. Dı́az
Source: Communications Chemistry (article, 2024-02-29)
Field: Materials Science — Surfaces, Coatings and Films

Sequestration within peptide coacervates improves the fluorescence intensity, kinetics, and limits of detection of dye-based DNA biosensors Peptide-based liquid-liquid phase separated domains, or coacervates, are a biomaterial gaining new interest due to their exciting potential in fields ranging from biosensing to drug delivery. In this study, we demonstrate that coacervates provide a simple and biocompatible medium to improve nucleic acid biosensors through the sequestration of both the biosensor and target strands within the coacervate, thereby increasing their local concentration. Using the well-established polyarginine (R<sub>9</sub>) - ATP coacervate system and an energy transfer-based DNA molecular beacon we observed three key improvements: i) a greater than 20-fold reduction of the limit of detection within coacervates when compared to control buffer solutions; ii) an increase in the kinetics, equilibrium was reached more than 4-times faster in coacervates; and iii) enhancement in the dye fluorescent quantum yields within the coacervates, resulting in greater signal-to-noise. The observed benefits translate into coacervates greatly improving bioassay functionality. Biosensor ; Coacervate ; Biocompatible material ; Fluorescence ; Nanotechnology ; Nucleic acid ; Chemistry ; Biomaterial ; Kinetics ; Peptide ; DNA ; Materials science ; Biophysics ; Chromatography ; Biochemistry ; Biomedical engineering ; Biology Polymer Surface Interaction Studies ; Supramolecular Self-Assembly in Materials ; Advanced biosensing and bioanalysis techniques
Authors: Shaikh Sheeran Naser | Abha R. Gupta | Anmol Choudhury | Anu Yadav | Adrija Sinha | Apoorv Kirti | Deobrat Singh | Małgorzata Kujawska | Nagendra Kumar Kaushik | Aishee Ghosh | S. S. De | Suresh K. Verma
Source: Biomedicine & Pharmacotherapy (review, 2024-08-28)
Field: Materials Science — Biomaterials

Biophysical translational paradigm of polymeric nanoparticle: Embarked advancement to brain tumor therapy Polymeric nanoparticles have emerged as promising contenders for addressing the intricate challenges encountered in brain tumor therapy due to their distinctive attributes, including adjustable size, biocompatibility, and controlled drug release kinetics. This review comprehensively delves into the latest developments in synthesizing, characterizing, and applying polymeric nanoparticles explicitly tailored for brain tumor therapy. Various synthesis methodologies, such as emulsion polymerization, nanoprecipitation, and template-assisted fabrication, are scrutinized within the context of brain tumor targeting, elucidating their advantages and limitations concerning traversing the blood-brain barrier. Furthermore, strategies pertaining to surface modification and functionalization are expounded upon to augment the stability, biocompatibility, and targeting prowess of polymeric nanoparticles amidst the intricate milieu of the brain microenvironment. Characterization techniques encompassing dynamic light scattering, transmission electron microscopy, and spectroscopic methods are scrutinized to evaluate the physicochemical attributes of polymeric nanoparticles engineered for brain tumor therapy. Moreover, a comprehensive exploration of the manifold applications of polymeric nanoparticles encompassing drug delivery, gene therapy, imaging, and combination therapies for brain tumours is undertaken. Special emphasis is placed on the encapsulation of diverse therapeutics within polymeric nanoparticles, thereby shielding them from degradation and enabling precise targeting within the brain. Additionally, recent advancements in stimuli-responsive and multifunctional polymeric nanoparticles are probed for their potential in personalized medicine and theranostics tailored for brain tumours. In essence, this review furnishes an all-encompassing overview of the recent strides made in tailoring polymeric nanoparticles for brain tumor therapy, illuminating their synthesis, characterization, and multifaceted application. Nanotechnology ; Biocompatibility ; Nanoparticle ; Drug delivery ; Surface modification ; Context (archaeology) ; Materials science ; Brain tumor ; Chemistry ; Medicine ; Biology Nanoparticle-Based Drug Delivery ; RNA Interference and Gene Delivery ; Nanoplatforms for cancer theranostics
Authors: Anli Dino A | Ganesh Kishore
Source: Discover Environment (article, 2024-02-22)
Field: Materials Science — Biomaterials

Microalgae: an emerging source of bioplastics production Abstract Bioplastics has gained attention as a sustainable alternative to traditional petroleum-based plastics. Microalgae have become one of the more promising and environmentally benign feedstocks to produce bioplastics. The goal of this in-depth review study is to address both the possibilities and the difficulties of manufacturing microalgae-based bioplastics. The review begins by discussing the negative impacts that commercial plastics have on the environment, pollution, and resource depletion. It then introduces the idea of bioplastics and discusses their importance in reducing the previously mentioned issues brought on by plastics. The article discusses the distinctive qualities of microalgae as a sustainable biomass source, noting their rapid development, high lipid content, and low need for both land and water. The various production processes and procedures used to create microalgae-based bioplastics are thoroughly explored. To determine whether the mechanical, thermal, and barrier qualities were appropriate for different applications, they were examined. Biodegradability and shelf life are factors in environmental impact assessments that highlight their potential to help mitigate the negative effects of plastics. Economic viability is a crucial factor that is examined through cost analyses and discussions of the prospects and incentives for market growth. To provide a glimpse into the future of microalgae-based bioplastics as a sustainable material option, current trends and innovations are emphasized. This review advances our knowledge of microalgae-based bioplastics in the race for a more sustainable plastics industry by offering a fair evaluation of their advantages, disadvantages, and uses. Graphical Abstract Bioplastic ; Production (economics) ; Biochemical engineering ; Environmental science ; Engineering ; Waste management ; Economics biodegradable polymer synthesis and properties ; Microplastics and Plastic Pollution ; Algal biology and biofuel production
Authors: Hiroyuki Matsukizono | Yusuke Sakamoto | Yasushi Okumura | Hirotsugu Kikuchi
Source: The Journal of Physical Chemistry Letters (article, 2024-04-10)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Exploring the Impact of Linkage Structure in Ferroelectric Nematic and Smectic Liquid Crystals The liquid crystal molecule 3-fluoro-4-(3,4,5-trifluorophenyl)phenyl 2,6-difluoro-4-(<i>trans</i>-5-n-propyl-1,3-dioxane-2-yl)benzoate (DIO) has attracted considerable interest owing to its unique ferroelectric nematic phase and extraordinarily high dielectric constant. To expand the DIO series, novel analogs with 1,3-dioxane units converted to ester units (EST analogs) were synthesized, and their physical properties were characterized. The EST analogs exhibited ferroelectric phases similar to those of the corresponding DIO analogs. Interestingly, an EST analogue featuring a defluorinated benzoate unit exhibited a ferroelectric smectic A phase, despite its smaller longitudinal dipole moment of 6.9 D. This result diverges from the common knowledge that the formation of large longitudinal dipoles is traditionally effective in the emergence of ferroelectric phases. Unlike the DIO series, the EST analogs can be readily obtained without the formation of undesired geometric isomers, which is advantageous for practical applications. The results of this study provide valuable insights into the design of liquid-crystalline materials expressing ferroelectric phases. Ferroelectricity ; Liquid crystal ; Dielectric ; Dipole ; Phase (matter) ; Antiferroelectricity ; Materials science ; Crystallography ; Molecule ; Stereochemistry ; Chemistry ; Organic chemistry ; Optoelectronics Liquid Crystal Research Advancements ; Nonlinear Dynamics and Pattern Formation ; Surfactants and Colloidal Systems
Authors: Shirin M. Usmani | Susanne Bremer‐Hoffmann | Karlien Cheyns | Francesco Cubadda | Verónica I. Dumit | Sylvia E. Escher | Valérie Fessard | Arno C. Gutleb | Thibaut Léger | Yuk‐Chien Liu | Jan Mast | Emily McVey | Birgit Mertens | Daniela Montalvo | Agnes G. Oomen | Vera Ritz | Tommaso Serchi | Holger Sieg | Katherina Siewert | D. Stanco | Eveline Verleysen | Olimpia Vincentini | Calvin Yeo | Dingyi Yu | Meike van der Zande | Andrea Haase
Source: EFSA Supporting Publications (article, 2024-09-01)
Field: Materials Science — Materials Chemistry

Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges Abstract New Approach Methodologies (NAMs), broadly understood to include in silico, in chemico, in vitro and ex vivo methods, show great potential in advancing risk assessment albeit their regulatory implementation is lagging. The EFSA Guidance on risk assessment of nanomaterials (EFSA Guidance on Nano‐RA) suggests nano‐specific risk assessment is best achieved through Integrated Approaches to Testing and Assessment (IATAs) with NAMs as the first choice to generate new information. Integrating NAMs in risk assessment promises several advantages such as a better human focus, more detailed insights into molecular mechanisms and a higher efficacy. However, applying NAMs to NMs also poses considerable challenges such as issues related to dispersion stability, dosimetry, agglomeration, dissolution, transformations or assay interferences. Significant efforts are being undertaken by standardisation organisations and research projects to establish various NAMs for NMs. Here a thorough review is provided covering NAMs that will be potentially useful for risk assessment of NMs in the food and feed sector. It follows the structure of the EFSA Guidance on Nano‐RA and expands it, where needed, to support decision‐making in selection of NAMs for NM risk assessment. The review begins with an overview on nano‐specific NAM‐frameworks, followed by a description of individual NAMs including those relevant to NM physicochemical characterisation, exposure and hazard assessment covering toxicodynamics and toxicokinetics. The focus is on NAMs concerning NM degradation/dissolution, genotoxicity, cytotoxicity, oxidative stress, (pro‐)inflammation, and barrier integrity as those are important endpoints for initial screening according to the EFSA framework. As a result, in total 267 individual nano‐relevant NAMs, mostly “not validated” (with a few notable exceptions), were included in this review. Validation notwithstanding, NAMs could already prove relevant and reliable for risk assessment of NMs, especially in integrated approaches. Food sector ; Risk analysis (engineering) ; Business ; Biology ; Agriculture Nanoparticles: synthesis and applications ; Microplastics and Plastic Pollution
Authors: Emanuelle Braga | Luana Damasceno | Chastryane Barros de Sousa Silva | Lucas F. M. da Silva | Maria Madalena de Aguiar Cavalcante | Antônio César Honorato Barreto | Sílvia Agostinho da Silva | F. Murilo T. Luna | Luciana Medeiros Bertini | Tássio Lessa do Nascimento | Maria Alexsandra de Sousa Rios
Source: Fuels (article, 2024-03-18)
Field: Chemistry — Analytical Chemistry

1H NMR and UV-Vis as Analytical Techniques to Evaluate Biodiesel Conversion and Oxidative Stability The present study evaluated the applicability of 1H NMR and UV-Vis spectroscopies as analytical techniques for the characterization and determination of biodiesel conversion and for monitoring the oxidative stability of biodiesel samples with antioxidants. For this study, safflower and babassu biodiesels were obtained through transesterification, and physicochemical properties confirmed the success of both reactions. A bench-top accelerated oxidation system was used as an alternative to the Rancimat® method, with samples of 6.0 g heated at 110 ± 5 °C and collected every 2 h for 12 h. The agreement for biodiesel conversions was good, with divergences between 2% and 0.4% for safflower biodiesel and 1.9% for babassu biodiesel. As for UV-Vis spectroscopy, the technique showed the same trend as the Rancimat® method, showing efficiency in evaluating the oxidative stability of safflower biodiesel and in the performance of antioxidants BHT and DMP-30. The accuracy of NMR signals integration for mixtures of safflower oil and safflower biodiesel and the use of UV-Vis spectroscopy associated with a bench-top accelerated oxidation system to investigate the performance of phenolic and amine antioxidants in safflower and babassu biodiesel were explored for the first time, showing results close to the standard methods. Therefore, 1H NMR and UV-Vis spectroscopies could be applied as alternatives to the GC and Rancimat® methods to determine conversion and monitor the oxidative stability of biodiesel rapidly and practically. Biodiesel ; Transesterification ; Chemistry ; Proton NMR ; Biodiesel production ; Organic chemistry ; Nuclear chemistry ; Catalysis Spectroscopy and Chemometric Analyses ; Biodiesel Production and Applications ; Water Quality Monitoring and Analysis
Authors: Sangjeong Lee | Hyunwoo Kim
Source: PLoS Computational Biology (article, 2024-02-28)
Field: Chemistry — Spectroscopy

Bidirectional de novo peptide sequencing using a transformer model In proteomics, a crucial aspect is to identify peptide sequences. De novo sequencing methods have been widely employed to identify peptide sequences, and numerous tools have been proposed over the past two decades. Recently, deep learning approaches have been introduced for de novo sequencing. Previous methods focused on encoding tandem mass spectra and predicting peptide sequences from the first amino acid onwards. However, when predicting peptides using tandem mass spectra, the peptide sequence can be predicted not only from the first amino acid but also from the last amino acid due to the coexistence of b-ion (or a- or c-ion) and y-ion (or x- or z-ion) fragments in the tandem mass spectra. Therefore, it is essential to predict peptide sequences bidirectionally. Our approach, called NovoB, utilizes a Transformer model to predict peptide sequences bidirectionally, starting with both the first and last amino acids. In comparison to Casanovo, our method achieved an improvement of the average peptide-level accuracy rate of approximately 9.8% across all species. Peptide ; Peptide sequence ; Amino acid ; Tandem mass spectrometry ; Computational biology ; Biology ; Chemistry ; Mass spectrometry ; Biochemistry ; Chromatography ; Gene Advanced Proteomics Techniques and Applications ; Mass Spectrometry Techniques and Applications ; Genomics and Phylogenetic Studies
Authors: Xiaoxue Lang | Xiangtao Wang | Meihua Han | Yifei Guo
Source: International Journal of Nanomedicine (article, 2024-05-01)
Field: Materials Science — Biomaterials

Nanoparticle-Mediated Synergistic Chemoimmunotherapy for Cancer Treatment Until now, there has been a lack of effective strategies for cancer treatment. Immunotherapy has high potential in treating several cancers but its efficacy is limited as a monotherapy. Chemoimmunotherapy (CIT) holds promise to be widely used in cancer treatment. Therefore, identifying their involvement and potential synergy in CIT approaches is decisive. Nano-based drug delivery systems (NDDSs) are ideal delivery systems because they can simultaneously target immune cells and cancer cells, promoting drug accumulation, and reducing the toxicity of the drug. In this review, we first introduce five current immunotherapies, including immune checkpoint blocking (ICB), adoptive cell transfer therapy (ACT), cancer vaccines, oncolytic virus therapy (OVT) and cytokine therapy. Subsequently, the immunomodulatory effects of chemotherapy by inducing immunogenic cell death (ICD), promoting tumor killer cell infiltration, down-regulating immunosuppressive cells, and inhibiting immune checkpoints have been described. Finally, the NDDSs-mediated collaborative drug delivery systems have been introduced in detail, and the development of NDDSs-mediated CIT nanoparticles has been prospected. Chemoimmunotherapy ; Nanoparticle ; Cancer ; Nanotechnology ; Cancer treatment ; Medicine ; Materials science ; Cancer research ; Immunotherapy ; Internal medicine Nanoparticle-Based Drug Delivery ; Nanoplatforms for cancer theranostics ; Immunotherapy and Immune Responses