jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Yue Yuan | Jonas Weber | Junzhu Li | Bo Tian | Yinchang Ma | Xixiang Zhang | Takashi Taniguchi | Kenji Watanabe | Mario Lanza
Source: Nature Communications (article, 2024-05-28)
Field: Materials Science — Materials Chemistry

On the quality of commercial chemical vapour deposited hexagonal boron nitride The semiconductors industry has put its eyes on two-dimensional (2D) materials produced by chemical vapour deposition (CVD) because they can be grown at the wafer level with small thickness fluctuations, which is necessary to build electronic devices and circuits. However, CVD-grown 2D materials can contain significant amounts of lattice distortions, which degrades the performance at the device level and increases device-to-device variability. Here we statistically analyse the quality of commercially available CVD-grown hexagonal boron nitride (h-BN) from the most popular suppliers. h-BN is of strategic importance because it is one of the few insulating 2D materials, and can be used as anti-scattering substrate and gate dielectric. We find that the leakage current and electrical homogeneity of all commercially available CVD h-BN samples are significantly worse than those of mechanically exfoliated h-BN of similar thickness. Moreover, in most cases the properties of the CVD h-BN samples analysed don't match the technical specifications given by the suppliers, and the sample-to-sample variability is unsuitable for the reproducible fabrication of capacitors, transistors or memristors in different batches. In the short term, suppliers should try to provide accurate sample specifications matching the properties of the commercialized materials, and researchers should keep such inaccuracies in mind; and in the middle term suppliers should try to reduce the density of defects to enable the fabrication of high-performance devices with high reliability and reproducibility. Materials science ; Fabrication ; Chemical vapor deposition ; Wafer ; Optoelectronics ; Homogeneity (statistics) ; Transistor ; Hexagonal boron nitride ; Boron nitride ; Dielectric ; Nanotechnology ; Computer science ; Electrical engineering ; Graphene ; Voltage Graphene research and applications ; Diamond and Carbon-based Materials Research ; Advancements in Semiconductor Devices and Circuit Design
Authors: Tomasz Pawel Czaja | Søren Balling Engelsen
Source: Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy (review, 2024-08-25)
Field: Chemistry — Analytical Chemistry

Why nothing beats NIRS technology: The green analytical choice for the future sustainable food production In this perspective paper we argue for the fact that near infrared (NIR) technology, due to its unique properties, will become an indispensable green sensor technology in the future digitalized and sustainable food production. The future of near infrared spectroscopy (NIRS) in green analytics is bright. Ongoing advancements in NIR technology, coupled with increased accessibility and integration with advanced multivariate data analysis such as machine learning and artificial intelligence will further amplify the impact of NIRS across food, agricultural, environmental, and renewable energy domains. The miniaturization, increased portability, and enhanced affordability of NIR instruments, coupled with its integration into emerging technologies, will empower a diverse range of industries and researchers to address pressing global challenges with unprecedented precision and efficiency. The implementation of NIR technology in process analytical technology will enable the transition to future digitalized and sustainable food production. In a future circular economy, where waste streams, co-products and water are reclaimed and valorized, continuous measurements are necessary and in many cases, there are no sensor alternatives to NIR technology. Software portability ; Sustainable agriculture ; Renewable energy ; Production (economics) ; Miniaturization ; Food processing ; Analytics ; Process engineering ; Biochemical engineering ; Nanotechnology ; Agriculture ; Data science ; Computer science ; Chemistry ; Engineering Spectroscopy and Chemometric Analyses ; Advanced Chemical Sensor Technologies ; Spectroscopy Techniques in Biomedical and Chemical Research
Authors: Zachary Cohen | Ryan M. Williams
Source: ACS Nano (review, 2024-12-19)
Field: Materials Science — Materials Chemistry

Single-Walled Carbon Nanotubes as Optical Transducers for Nanobiosensors In Vivo Semiconducting single-walled carbon nanotubes (SWCNTs) may serve as signal transducers for nanobiosensors. Recent studies have developed innovative methods of engineering molecularly specific sensors, while others have devised methods of deploying such sensors within live animals and plants. These advances may potentiate the use of implantable, noninvasive biosensors for continuous drug, disease, and contaminant monitoring based on the optical properties of single-walled carbon nanotubes (SWCNTs). Such tools have substantial potential to improve disease diagnostics, prognosis, drug safety, therapeutic response, and patient compliance. Outside of clinical applications, such sensors also have substantial potential in environmental monitoring or as research tools in the lab. However, substantial work remains to be done to realize these goals through further advances in materials science and engineering. Here, we review the current landscape of quantitative SWCNT-based optical biosensors that have been deployed in living plants and animals. Specifically, we focused this review on methods that have been developed to deploy SWCNT-based sensors in vivo as well as analytes that have been detected by SWCNTs in vivo. Finally, we evaluated potential future directions to take advantage of the promise outlined here toward field-deployable or implantable use in patients. Carbon nanotube ; Nanotechnology ; Biosensor ; Materials science ; Transducer ; In vivo ; Optical sensing ; Computer science ; Engineering ; Biotechnology ; Electrical engineering ; Biology Carbon Nanotubes in Composites ; Advanced biosensing and bioanalysis techniques ; Neuroscience and Neural Engineering
Authors: Anastasiia Skvortsova | Jeong Hyun Han | Andrea Tosovska | Polina Bainova | Ryeong Myeong Kim | Vasilii Burtsev | Mariia Erzina | Přemysl Fitl | Marie Urbanová | Václav Švorčı́k | In Han Ha | Ki Tae Nam | Oleksiy Lyutakov
Source: ACS Applied Materials & Interfaces (article, 2024-09-03)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Enantioselective Molecular Detection by Surface Enhanced Raman Scattering at Chiral Gold Helicoids on Grating Surfaces Distinct advantages of surface enhanced Raman scattering (SERS) in molecular detection can benefit the enantioselective discrimination of specific molecular configurations. However, many of the recent methods still lack versatility and require customized anchors to chemically interact with the studied analyte. In this work, we propose the utilization of helicoid-shaped chiral gold nanoparticles arranged in an ordered array on a gold grating surface for enantioselective SERS recognition. This arrangement ensured a homogeneous distribution of chiral plasmonic hot spots and facilitated the enhancement of the SERS response of targeted analytes through plasmon coupling between gold helicoid multimers (formed in the grating valleys) and adjacent regions of the gold grating. Naproxen enantiomers (<i>R</i>(+) and <i>S</i>(-)) were employed as model compounds, revealing a clear dependence of their SERS response on the chirality of the gold helicoids. Additionally, propranolol and penicillamine enantiomers were used to validate the universality of the proposed approach. Finally, numerical simulations were conducted to elucidate the roles of intensified local electric field and optical helicity density on the SERS signal intensity and on the chirality of the nanoparticles and enantiomers. Unlike previously reported methods, our approach relies on the excitation of a chiral plasmonic near-field and its interaction with the chiral environment of analyte molecules, obviating the need for the enantioselective entrapment of targeted molecules. Moreover, our method is not limited to specific analyte classes and can be applied to a broad range of chiral molecules. Materials science ; Raman scattering ; Grating ; Surface (topology) ; Nanotechnology ; Enantioselective synthesis ; Raman spectroscopy ; Optics ; Optoelectronics ; Organic chemistry ; Catalysis Gold and Silver Nanoparticles Synthesis and Applications ; Surface Chemistry and Catalysis ; Spectroscopy and Quantum Chemical Studies
Authors: Ghazal Basirinia | Muhammad Ali | Albert Comelli | Alessandro Sperandeo | Sebastiano Piana | Pierpaolo Alongi | Costanza Longo | Domenico Di Raimondo | Antonino Tuttolomondo | Viviana Benfante
Source: Cancers (review, 2024-09-28)
Field: Materials Science — Biomaterials

Theranostic Approaches for Gastric Cancer: An Overview of In Vitro and In Vivo Investigations Gastric cancer (GC) is the second most common cause of cancer-related death worldwide and a serious public health concern. This high death rate is mostly caused by late-stage diagnoses, which lead to poor treatment outcomes. Radiation immunotherapy and targeted therapies are becoming increasingly popular in GC treatment, in addition to surgery and systemic chemotherapy. In this review, we have focused on both in vitro and in vivo research, which presents a summary of recent developments in targeted therapies for gastric cancer. We explore targeted therapy approaches, including integrin receptors, HER2, Claudin 18, and glutathione-responsive systems. For instance, therapies targeting the integrin receptors such as the αvβ3 and αvβ5 integrins have shown promise in enhancing diagnostic precision and treatment efficacy. Furthermore, nanotechnology provides novel approaches to targeted drug delivery and imaging. These include glutathione-responsive nanoplatforms and cyclic RGD peptide-conjugated nanoparticles. These novel strategies seek to reduce systemic toxicity while increasing specificity and efficacy. To sum up, the review addresses the significance of personalized medicine and advancements in gastric cancer-targeted therapies. It explores potential methods for enhancing gastric cancer prognosis and treatment in the future. Medicine ; Cancer ; In vivo ; Targeted therapy ; Immunotherapy ; Cancer research ; Pharmacology ; Bioinformatics ; Internal medicine ; Biotechnology ; Biology Nanoparticle-Based Drug Delivery ; Immune cells in cancer ; Nanoplatforms for cancer theranostics
Authors: Charlotte Wouters | Musbah Nofal | Piero Mazzolini | Jijun Zhang | T. Remmele | Albert Kwasniewski | Oliver Bierwagen | M. Albrecht
Source: APL Materials (article, 2024-01-01)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Unraveling the atomic mechanism of the disorder–order phase transition from γ-Ga2O3 to β-Ga2O3 In this paper, we employ in situ transmission electron microscopy to study the disorder–order phase transition from amorphous Ga2O3 to γ-Ga2O3 and then to β-Ga2O3. The in situ studies are complemented by ex situ annealing experiments, of which the results are analyzed by x-ray diffraction and high resolution (scanning) transmission electron microscopy. Amorphous Ga2O3 deposited at 100 °C by molecular beam epitaxy crystallizes at 470 °C in the γ phase (Fd3̄m), which undergoes a phase transition to the β phase above 500 °C. Between 500° and 900 °C, we find a mixture of γ-Ga2O3 and β-Ga2O3 coexisting. Above 950 °C, we find only β-Ga2O3. Through our analyses and by considering symmetry relations, we have constructed a coincidence site lattice of both structures containing a common fcc-type sublattice occupied by oxygen atoms, the cation sites of β-Ga2O3 common to both phases, and partially occupied cation sites in the γ phase corresponding to the interstitial sites in the β phase. We assign the atomic displacements within this lattice responsible for transforming the initially disordered spinel structure with partially occupied cation sites into the well-ordered lattice of β-Ga2O3. We identify this transition as a reconstructive disorder-to-order phase transition, mediated by the exchange of cations to next nearest neighbor sites. Our model not only explains recent observations of the formation of γ-Ga2O3 during implantation for n-type doping and the subsequent recovery of β-Ga2O3 following annealing but also holds potential for inspiring understanding in other materials with similar phase transitions. Crystallography ; Materials science ; Annealing (glass) ; Amorphous solid ; Phase transition ; Transmission electron microscopy ; Interstitial defect ; Scanning transmission electron microscopy ; Electron diffraction ; Transition metal ; X-ray crystallography ; Condensed matter physics ; Doping ; Diffraction ; Chemistry ; Nanotechnology ; Physics ; Catalysis Ga2O3 and related materials ; ZnO doping and properties ; Advanced Photocatalysis Techniques
Authors: Fatemeh Madani | Hassan Morovvati | Thomas J. Webster | Sareh Najaf Asaadi | Seyed Mahdi Rezayat | Mahmoudreza Hadjighassem | Masood Khosravani | Mahdi Adabi
Source: Scientific Reports (article, 2024-08-22)
Field: Materials Science — Biomaterials

Combination chemotherapy via poloxamer 188 surface-modified PLGA nanoparticles that traverse the blood–brain–barrier in a glioblastoma model The effect of chemotherapy for anti-glioblastoma is limited due to insufficient drug delivery across the blood-brain-barrier. Poloxamer 188-coated nanoparticles can enhance the delivery of nanoparticles across the blood-brain-barrier. This study presents the design, preparation, and evaluation of a combination of PLGA nanoparticles (PLGA NPs) loaded with methotrexate (P-MTX NPs) and PLGA nanoparticles loaded with paclitaxel (P-PTX NPs), both of which were surface-modified with poloxamer188. Cranial tumors were induced by implanting C6 cells in a rat model and MRI demonstrated that the tumors were indistinguishable in the two rats with P-MTX NPs + P-PTX NPs treated groups. Brain PET scans exhibited a decreased brain-to-background ratio which could be attributed to the diminished metabolic tumor volume. The expression of Ki-67 as a poor prognosis factor, was significantly lower in P-MTX NPs + P-PTX NPs compared to the control. Furthermore, the biodistribution of PLGA NPs was determined by carbon quantum dots loaded into PLGA NPs (P-CQD NPs), and quantitative analysis of ex-vivo imaging of the dissected organs demonstrated that 17.2 ± 0.6% of the NPs were concentrated in the brain after 48 h. The findings highlight the efficacy of combination nanochemotherapy in glioblastoma treatment, indicating the need for further preclinical studies. Biodistribution ; PLGA ; Blood–brain barrier ; Poloxamer ; Drug delivery ; Paclitaxel ; Pharmacology ; Ex vivo ; Chemistry ; Glioblastoma ; Drug carrier ; Chemotherapy ; Nanoparticle ; Cancer research ; Medicine ; Materials science ; Drug ; Nanotechnology ; In vitro ; Surgery ; Internal medicine ; Biochemistry ; Central nervous system Nanoparticle-Based Drug Delivery ; Glioma Diagnosis and Treatment ; Graphene and Nanomaterials Applications
Authors: Yu Yang | Hao Lü | Dan Fang | Yuyuan Zhang | Yuteng Tang | Songsong Zhao | Jun Yan | Xiaojie Qin | Jianlei Shen | Fan Yang
Source: Aggregate (article, 2024-08-08)
Field: Materials Science — Electronic, Optical and Magnetic Materials

DNA‐encoded plasmonic bubbles aggregating dual‐microRNA SERS signals for cancer diagnosis Abstract Solid bubbles have expanded the SERS assay toolbox, but their detection performance in biofluids is still hampered by the irrational design of the plasmonic sensing interface. A plasmonic bubble aggregate‐driven DNA‐encoded SERS assay is reported here that enables simultaneous, ultrasensitive, and specific detection of multiple miRNAs in blood samples for accurate cancer diagnosis. In this assay, the buoyancy of plasmonic bubbles allows them to self‐aggregate at a droplet apex for SERS reconfiguration, form single‐layer bubble aggregates with plasmonic nanogaps, and prevent the coffee ring effect during evaporation assembly. Furthermore, DNA‐encoded plasmonic bubbles seamlessly couple with dual‐color catalytic hybridization assembly to amplify the specific miRNA‐responsive Raman signal, and function as both an analyte concentrator and a Raman signal aggregator without external forces. Using these merits, this magnet‐free, portable assay achieves femtomolar dual‐miRNA quantitation with single‐base resolution, simultaneous miRNA detection across four cell lines, and accurate cancer diagnosis (AUC = 1) via analyzing 40 blood samples with machine learning, thus providing a promising tool for clinical diagnosis. microRNA ; Plasmon ; Dual (grammatical number) ; Computational biology ; DNA ; Cancer ; Nanotechnology ; Biology ; Materials science ; Optoelectronics ; Gene ; Genetics Gold and Silver Nanoparticles Synthesis and Applications ; Extracellular vesicles in disease ; Biosensors and Analytical Detection
Authors: Weibao He | Xiang’ai Cheng | Siyang Hu | Ziheng Ren | Zhongyi Yu | Shun Wan | Yuze Hu | Tian Jiang
Source: Light Science & Applications (article, 2024-06-25)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Color coded metadevices toward programmed terahertz switching Abstract Terahertz modulators play a critical role in high-speed wireless communication, non-destructive imaging, and so on, which have attracted a large amount of research interest. Nevertheless, all-optical terahertz modulation, an ultrafast dynamical control approach, remains to be limited in terms of encoding and multifunction. Here we experimentally demonstrated an optical-programmed terahertz switching realized by combining optical metasurfaces with the terahertz metasurface, resulting in 2-bit dual-channel terahertz encoding. The terahertz metasurface, made up of semiconductor islands and artificial microstructures, enables effective all-optical programming by providing multiple frequency channels with ultrafast modulation at the nanosecond level. Meanwhile, optical metasurfaces covered in terahertz metasurface alter the spatial light field distribution to obtain color code. According to the time-domain coupled mode theory analysis, the energy dissipation modes in terahertz metasurface can be independently controlled by color excitation, which explains the principle of 2-bit encoding well. This work establishes a platform for all-optical programmed terahertz metadevices and may further advance the application of composite metasurface in terahertz manipulation. Terahertz radiation ; Optoelectronics ; Optics ; Terahertz gap ; Photomixing ; Terahertz time-domain spectroscopy ; Ultrashort pulse ; Modulation (music) ; Physics ; Terahertz spectroscopy and technology ; Photonics ; Terahertz metamaterials ; Materials science ; Far-infrared laser ; Laser Metamaterials and Metasurfaces Applications ; Terahertz technology and applications ; Molecular Communication and Nanonetworks
Authors: Xiuli Jing | Yankai Liu | Xuzhe Liu | Yi Zhang | Guanzhu Wang | Fei Yang | Yani Zhang | Dayong Chang | Zhenlu Zhang | Chun‐Xiang You | Shuai Zhang | Xiao‐Fei Wang
Source: Horticulture Research (article, 2024-01-12)
Field: Materials Science — Materials Chemistry

Enhanced photosynthetic efficiency by nitrogen-doped carbon dots via plastoquinone-involved electron transfer in apple Artificially enhancing photosynthesis is critical for improving crop yields and fruit qualities. Nanomaterials have demonstrated great potential to enhance photosynthetic efficiency; however, the mechanisms underlying their effects are poorly understood. This study revealed that the electron transfer pathway participated in nitrogen-doped carbon dots (N-CDs)-induced photosynthetic efficiency enhancement (24.29%), resulting in the improvements of apple fruit qualities (soluble sugar content: 11.43%) in the orchard. We also found that N-CDs alleviated <i>mterf5</i> mutant-modulated photosystem II (PSII) defects, but not <i>psa3</i> mutant-modulated photosystem I (PSI) defects, suggesting that the N-CDs-targeting sites were located between PSII and PSI. Measurements of chlorophyll fluorescence parameters suggested that plastoquinone (PQ), the mobile electron carrier in the photosynthesis electron transfer chain (PETC), was the photosynthesis component that N-CDs targeted. <i>In vitro</i> experiments demonstrated that plastoquinone-9 (PQ-9) could accept electrons from light-excited N-CDs to produce the reduced plastoquinone 9 (PQH<sub>2</sub>-9). These findings suggested that N-CDs, as electron donors, offer a PQ-9-involved complement of PETC to improve photosynthesis and thereby fruit quality. Our study uncovered a mechanism by which nanomaterials enhanced plant photosynthesis and provided some insights that will be useful in the design of efficient nanomaterials for agricultural/horticultural applications. Plastoquinone ; Photosynthesis ; Photosystem II ; Photosystem I ; Photosynthetic efficiency ; Chlorophyll fluorescence ; Biology ; Biophysics ; Electron transfer ; Photochemistry ; Botany ; Chloroplast ; Chemistry ; Thylakoid ; Biochemistry Carbon and Quantum Dots Applications ; Photosynthetic Processes and Mechanisms ; Plant Stress Responses and Tolerance
Authors: Gilbert S. Omenn | Lydie Lane | Christopher M. Overall | Cecilia Lindskog | Charles Pineau | Nicolle H. Packer | Ileana M. Cristea | Susan T. Weintraub | Sandra Orchard | Michael H. A. Roehrl | Edouard C. Nice | Tiannan Guo | Jennifer E. Van Eyk | Siqi Liu | Nuno Bandeira | Ruedi Aebersold | Robert L. Moritz | Eric W. Deutsch
Source: Journal of Proteome Research (article, 2024-01-17)
Field: Chemistry — Spectroscopy

The 2023 Report on the Proteome from the HUPO Human Proteome Project Since 2010, the Human Proteome Project (HPP), the flagship initiative of the Human Proteome Organization (HUPO), has pursued two goals: (1) to credibly identify the protein parts list and (2) to make proteomics an integral part of multiomics studies of human health and disease. The HPP relies on international collaboration, data sharing, standardized reanalysis of MS data sets by PeptideAtlas and MassIVE-KB using HPP Guidelines for quality assurance, integration and curation of MS and non-MS protein data by neXtProt, plus extensive use of antibody profiling carried out by the Human Protein Atlas. According to the neXtProt release 2023-04-18, protein expression has now been credibly detected (PE1) for 18,397 of the 19,778 neXtProt predicted proteins coded in the human genome (93%). Of these PE1 proteins, 17,453 were detected with mass spectrometry (MS) in accordance with HPP Guidelines and 944 by a variety of non-MS methods. The number of neXtProt PE2, PE3, and PE4 missing proteins now stands at 1381. Achieving the unambiguous identification of 93% of predicted proteins encoded from across all chromosomes represents remarkable experimental progress on the Human Proteome parts list. Meanwhile, there are several categories of predicted proteins that have proved resistant to detection regardless of protein-based methods used. Additionally there are some PE1-4 proteins that probably should be reclassified to PE5, specifically 21 LINC entries and ∼30 HERV entries; these are being addressed in the present year. Applying proteomics in a wide array of biological and clinical studies ensures integration with other omics platforms as reported by the Biology and Disease-driven HPP teams and the antibody and pathology resource pillars. Current progress has positioned the HPP to transition to its Grand Challenge Project focused on determining the primary function(s) of every protein itself and in networks and pathways within the context of human health and disease. Human proteome project ; Proteome ; Human Protein Atlas ; Proteomics ; Computational biology ; Biology ; Bioinformatics ; Protein expression ; Genetics ; Gene Advanced Proteomics Techniques and Applications ; Metabolomics and Mass Spectrometry Studies ; Machine Learning in Bioinformatics