jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Zhaohua Dai
Source: Sensors (review, 2023-03-15)
Field: Chemistry — Electrochemistry

Recent Advances in the Development of Portable Electrochemical Sensors for Controlled Substances This review article summarizes recent achievements in developing portable electrochemical sensing systems for the detection and/or quantification of controlled substances with potential on-site applications at the crime scene or other venues and in wastewater-based epidemiology. Electrochemical sensors employing carbon screen-printed electrodes (SPEs), including a wearable glove-based one, and aptamer-based devices, including a miniaturized aptamer-based graphene field effect transistor platform, are some exciting examples. Quite straightforward electrochemical sensing systems and methods for controlled substances have been developed using commercially available carbon SPEs and commercially available miniaturized potentiostats. They offer simplicity, ready availability, and affordability. With further development, they might become ready for deployment in forensic field investigation, especially when fast and informed decisions are to be made. Slightly modified carbon SPEs or SPE-like devices might be able to offer higher specificity and sensitivity while they can still be used on commercially available miniaturized potentiostats or lab-fabricated portable or even wearable devices. Affinity-based portable devices employing aptamers, antibodies, and molecularly imprinted polymers have been developed for more specific and sensitive detection and quantification. With further development of both hardware and software, the future of electrochemical sensors for controlled substances is bright. Aptamer ; Nanotechnology ; Wearable computer ; Computer science ; Wearable technology ; Materials science ; Embedded system Electrochemical Analysis and Applications ; Electrochemical sensors and biosensors ; Advanced biosensing and bioanalysis techniques
Authors: Zhou Chen | Mengdi Guan | Bian Yi | Xichen Yin
Source: Biosensors (review, 2023-12-25)
Field: Materials Science — Biomaterials

Multifunctional Electrospun Nanofibers for Biosensing and Biomedical Engineering Applications Nanotechnology is experiencing unprecedented developments, leading to the advancement of functional nanomaterials. The properties that stand out include remarkable porosity, high-specific surface area, excellent loading capacity, easy modification, and low cost make electrospun nanofibers. In the biomedical field, especially in biosensors, they exhibit amazing potential. This review introduces the principle of electrospinning, describes several structures and biomaterials of electrospun nanofibers used for biomedicine, and summarizes the applications of this technology in biosensors and other biomedical applications. In addition, the technical challenges and limitations of electrospinning for biomedicine are discussed; however, more research work is needed to elucidate its full potential. Electrospinning ; Nanofiber ; Nanotechnology ; Biomedicine ; Materials science ; Biosensor ; Polymer ; Bioinformatics ; Composite material Electrospun Nanofibers in Biomedical Applications ; Advanced Sensor and Energy Harvesting Materials ; Conducting polymers and applications
Authors: Ji Hwan Kim | Roman Halaksa | Il‐Young Jo | Hyungju Ahn | Peter A. Gilhooly‐Finn | Inho Lee | Sungjun Park | Christian B. Nielsen | Myung‐Han Yoon
Source: Nature Communications (article, 2023-11-28)
Field: Materials Science — Polymers and Plastics

Peculiar transient behaviors of organic electrochemical transistors governed by ion injection directionality Despite the growing interest in dynamic behaviors at the frequency domain, there exist very few studies on molecular orientation-dependent transient responses of organic mixed ionic-electronic conductors. In this research, we investigated the effect of ion injection directionality on transient electrochemical transistor behaviors by developing a model mixed conductor system. Two polymers with similar electrical, ionic, and electrochemical characteristics but distinct backbone planarities and molecular orientations were successfully synthesized by varying the co-monomer unit (2,2'-bithiophene or phenylene) in conjunction with a novel 1,4-dithienylphenylene-based monomer. The comprehensive electrochemical analysis suggests that the molecular orientation affects the length of the ion-drift pathway, which is directly correlated with ion mobility, resulting in peculiar OECT transient responses. These results provide the general insight into molecular orientation-dependent ion movement characteristics as well as high-performance device design principles with fine-tuned transient responses. Materials science ; Electrochemistry ; Ion ; Transient (computer programming) ; Ionic bonding ; Chemical physics ; Transistor ; Monomer ; Directionality ; Electrical conductor ; Nanotechnology ; Electrode ; Optoelectronics ; Polymer ; Chemistry ; Voltage ; Computer science ; Electrical engineering ; Physical chemistry ; Organic chemistry Conducting polymers and applications ; Organic Electronics and Photovoltaics ; Organic Light-Emitting Diodes Research
Authors: Jiaqi Liu | Jiafeng Miao | Hao Wang | Yanli Gai | Jing Li
Source: AIChE Journal (article, 2023-01-10)
Field: Chemistry — Inorganic Chemistry

Enhanced one‐step purification of <scp>C<sub>2</sub>H<sub>4</sub></scp> from <scp>C<sub>2</sub>H<sub>2</sub></scp>/<scp>C<sub>2</sub>H<sub>4</sub></scp>/<scp>C<sub>2</sub>H<sub>6</sub></scp> mixtures by fluorinated <scp>Zr‐MOF</scp> Abstract The extraction of C 2 H 4 from C 2 H 6 /C 2 H 4 /C 2 H 2 mixtures is of great significance in the chemical industry for C 2 H 4 production but the process remains challenging due to the similarity of these C 2 hydrocarbon species in their molecular size and physical properties. Here, we report the fluorination of a stable Zr‐MOF, UiO‐66, to fine‐tune the pore dimensions and pore functionality. In particular, UiO‐66‐CF 3 shows notably preferential adsorption of C 2 H 6 and C 2 H 2 over C 2 H 4 , with C 2 H 2 /C 2 H 4 and C 2 H 6 /C 2 H 4 selectivities of 1.4 and 1.9, respectively. Theoretical calculations provide insight into the binding sites of UiO‐66‐CF 3 for C 2 hydrocarbon adsorption. Breakthrough experiments further confirmed the capability of the material for purification of C 2 H 4 from C 2 H 2 /C 2 H 4 /C 2 H 6 ternary mixtures, evidenced by the high purity C 2 H 4 (99.9%+) obtained directly from outlet gas. Chemistry ; Ternary operation ; Hydrocarbon ; Adsorption ; Extraction (chemistry) ; Crystallography ; Stereochemistry ; Physical chemistry ; Chromatography ; Organic chemistry Metal-Organic Frameworks: Synthesis and Applications ; Inorganic Fluorides and Related Compounds ; Boron and Carbon Nanomaterials Research
Authors: Frédéric Dumur
Source: European Polymer Journal (article, 2023-03-14)
Field: Chemistry — Organic Chemistry

Recent advances on photoinitiating systems designed for solar photocrosslinking polymerization reactions Photopolymer ; Polymerization ; Sunlight ; Materials science ; Nanotechnology ; Daylight ; Process engineering ; Polymer ; Optics ; Physics ; Engineering ; Composite material Photopolymerization techniques and applications ; Advanced Polymer Synthesis and Characterization ; Photochromic and Fluorescence Chemistry
Authors: Marina O. Barsukova | Aleksandr A. Sapianik | Vincent Guillerm | Aleksander Shkurenko | Aslam C. Shaikh | Prakash T. Parvatkar | Prashant M. Bhatt | Mickaële Bonneau | Abdulhadi Alhaji | Osama Shekhah | Salvador R. G. Balestra | Rocío Semino | Guillaume Maurin | Mohamed Eddaoudi
Source: Nature Synthesis (article, 2023-10-02)
Field: Chemistry — Inorganic Chemistry

Face-directed assembly of tailored isoreticular MOFs using centring structure-directing agents Abstract Building blocks with low connectivity and no embedded directionality are prone to polymorphism, as demonstrated by the diversity of 4-connected zeolitic nets (&gt;250). As a result, their deployment for design in reticular and isoreticular chemistries remains a challenge. However, the ability to control geometrical peculiarities offers potential to deviate from the assembly of default structures. Here we report the face-directed assembly of &gt;20 isoreticular zeolite-like metal–organic frameworks (ZMOFs) by using polytopic expanding and tightening centring structure-directing agents (cSDAs). The cSDAs are selected with the appropriate geometrical coding information to alter and control the orientation of adjacent supermolecular building blocks. The ZMOFs have an underlying sodalite ( sod ) topology that is remarkably suited for the rational assembly of multinary materials. In addition to a variety of metal cations (In, Fe, Co and Ni), a diverse range of cSDAs (di-, tri-, tetra-, hexa-, pyridyl or imidazole) are used and combined. Our approach enables isoreticular possibilities at both extremities of the porous materials spectrum: In- sod -ZMOF-102 exhibits small pore aperture suitable for efficient separation, while Fe- sod -ZMOF-320 with 48-Å-wide mesopores exhibits high hydrogen uptake, methane storage working capacity and a high gravimetric working capacity for oxygen. Centring ; Mesoporous material ; Materials science ; Sodalite ; Rational design ; Nanotechnology ; Zeolite ; Topology (electrical circuits) ; Chemistry ; Chemical engineering ; Organic chemistry ; Engineering ; Mechanical engineering Metal-Organic Frameworks: Synthesis and Applications ; Covalent Organic Framework Applications ; Zeolite Catalysis and Synthesis
Authors: Gang Liu | Shaobo Liu | Cui Lai | Lei Qin | Mingming Zhang | Yixia Li | Mengyi Xu | Dengsheng Ma | Fuhang Xu | Shiyu Liu | Mingyang Dai | Qiang Chen
Source: Small (article, 2023-12-24)
Field: Materials Science — Materials Chemistry

Strategies for Enhancing the Photocatalytic and Electrocatalytic Efficiency of Covalent Triazine Frameworks for CO<sub>2</sub> Reduction Converting carbon dioxide (CO<sub>2</sub>) into fuel and high-value-added chemicals is considered a green and effective way to solve global energy and environmental problems. Covalent triazine frameworks (CTFs) are extensively utilized as an emerging catalyst for photo/electrocatalytic CO<sub>2</sub> reduction reaction (CO<sub>2</sub>RR) recently recognized for their distinctive qualities, including excellent thermal and chemical stability, π-conjugated structure, rich nitrogen content, and a strong affinity for CO<sub>2</sub>, etc. Nevertheless, single-component CTFs have the problems of accelerated recombination of photoexcited electron-hole pairs and restricted conductivity, which limit their application for photo/electrocatalytic CO<sub>2</sub>RR. Therefore, emphasis will then summarize the strategies for enhancing the photocatalytic and electrocatalytic efficiency of CTFs for CO<sub>2</sub>RR in this paper, including atom doping, constructing a heterojunction structure, etc. This review first illustrates the synthesis strategies of CTFs and the advantages of CTFs in the field of photo/electrocatalytic CO<sub>2</sub>RR. Subsequently, the mechanism of CTF-based materials in photo/electrocatalytic CO<sub>2</sub>RR is described. Lastly, the challenges and future prospects of CTFs in photo/electrocatalytic CO<sub>2</sub>RR are addressed, which offers a fresh perspective for the future development of CTFs in photo/electrocatalytic CO<sub>2</sub>RR. Electrocatalyst ; Triazine ; Materials science ; Photocatalysis ; Nanotechnology ; Catalysis ; Covalent bond ; Conjugated system ; Electrochemical reduction of carbon dioxide ; Combinatorial chemistry ; Chemistry ; Electrochemistry ; Polymer ; Organic chemistry ; Physical chemistry ; Polymer chemistry ; Electrode Covalent Organic Framework Applications ; CO2 Reduction Techniques and Catalysts ; Advanced Photocatalysis Techniques
Authors: Yuwei Liu | Ye‐Hui Chen | Jun Kee Cheng | Shao‐Hua Xiang | Bin Tan
Source: Chemical Synthesis (article, 2023-01-01)
Field: Chemistry — Organic Chemistry

Enantioselective synthesis of 3-arylindole atropisomers via organocatalytic indolization of iminoquinones The direct enantioselective construction of axially chiral 3-arylindole frameworks via nucleophilic addition of 2-substituted indoles to iminoquinones has been achieved with high efficiencies under mild chiral phosphoric acid (CPA) catalytic conditions. The utility of this method was demonstrated in successful scale-up syntheses without compromising the product yields and enantioselectivities. The oxidation of products yields axially chiral heteroaryl-p-quinone monoimine, which could be subjected to structural diversification via addition of nucleophiles. Enantioselective synthesis ; Atropisomer ; Nucleophile ; Phosphoric acid ; Chemistry ; Catalysis ; Combinatorial chemistry ; Organic chemistry Axial and Atropisomeric Chirality Synthesis ; Nonlinear Waves and Solitons ; Algebraic structures and combinatorial models
Authors: Lei Shi | Xiaoping Xue | Biqiong Hong | Qigang Li | Zhenhua Gu
Source: ACS Central Science (article, 2023-03-20)
Field: Chemistry — Organic Chemistry

Dirhodium(II)/Phosphine Catalyst with Chiral Environment at Bridging Site and Its Application in Enantioselective Atropisomer Synthesis A dirhodium(II)/phosphine catalyst with a chiral environment at the bridging site was developed for the asymmetric arylation of phenanthrene-9,10-diones with arylboronic acids. In contrast to the classic chiral bridging carboxylic acid (or derivatives) ligand strategy of bimetallic dirhodium(II) catalysis, in this reaction, tuning both axial and bridging ligands realized the first Rh<sub>2</sub>(OAc)<sub>4</sub>/phosphine-catalyzed highly enantioselective carbonyl addition reaction. The kinetic analysis reveals that dirhodium(II) and arylboronic acid follow the first-order kinetics, while phenanthrene-9,10-dione is zeroth-order. These data supported the proposed catalytic cycle, where the key intermediate in the rate-determining step involved the dirhodium(II) complex and arylboronic acid. Finally, axially chiral biaryls were prepared based on a newly developed oxidative ring-opening reaction of α-hydroxyl ketones with a base and molecular oxygen, which featured a central-to-axial chirality transfer radical β-scission step. Enantioselective synthesis ; Chemistry ; Phosphine ; Catalysis ; Phenanthrene ; Chirality (physics) ; Axial chirality ; Atropisomer ; Kinetic resolution ; Combinatorial chemistry ; Oxidative addition ; Hydroformylation ; Stereochemistry ; Rhodium ; Organic chemistry Axial and Atropisomeric Chirality Synthesis ; Molecular spectroscopy and chirality ; Catalytic C–H Functionalization Methods
Authors: Débora A. Moreira | Sofia Duque Santos | Victoria Leiro | Ana Paula Pêgo
Source: Pharmaceutics (review, 2023-03-24)
Field: Materials Science — Polymers and Plastics

Dendrimers and Derivatives as Multifunctional Nanotherapeutics for Alzheimer’s Disease Alzheimer's disease (AD) is the most prevalent form of dementia. It affects more than 30 million people worldwide and costs over US$ 1.3 trillion annually. AD is characterized by the brain accumulation of amyloid β peptide in fibrillar structures and the accumulation of hyperphosphorylated tau aggregates in neurons, both leading to toxicity and neuronal death. At present, there are only seven drugs approved for the treatment of AD, of which only two can slow down cognitive decline. Moreover, their use is only recommended for the early stages of AD, meaning that the major portion of AD patients still have no disease-modifying treatment options. Therefore, there is an urgent need to develop efficient therapies for AD. In this context, nanobiomaterials, and dendrimers in particular, offer the possibility of developing multifunctional and multitargeted therapies. Due to their intrinsic characteristics, dendrimers are first-in-class macromolecules for drug delivery. They have a globular, well-defined, and hyperbranched structure, controllable nanosize and multivalency, which allows them to act as efficient and versatile nanocarriers of different therapeutic molecules. In addition, different types of dendrimers display antioxidant, anti-inflammatory, anti-bacterial, anti-viral, anti-prion, and most importantly for the AD field, anti-amyloidogenic properties. Therefore, dendrimers can not only be excellent nanocarriers, but also be used as drugs per se. Here, the outstanding properties of dendrimers and derivatives that make them excellent AD nanotherapeutics are reviewed and critically discussed. The biological properties of several dendritic structures (dendrimers, derivatives, and dendrimer-like polymers) that enable them to be used as drugs for AD treatment will be pointed out and the chemical and structural characteristics behind those properties will be analysed. The reported use of these nanomaterials as nanocarriers in AD preclinical research is also presented. Finally, future perspectives and challenges that need to be overcome to make their use in the clinic a reality are discussed. Dendrimer ; Nanocarriers ; Context (archaeology) ; Nanotechnology ; Drug delivery ; Dementia ; Chemistry ; Nanomedicine ; Alzheimer's disease ; Disease ; Medicine ; Materials science ; Biology ; Nanoparticle ; Biochemistry Dendrimers and Hyperbranched Polymers ; Alzheimer's disease research and treatments ; Computational Drug Discovery Methods
Authors: Bibek Prajapati | Madan D. Ambhore | Duy‐Khoi Dang | Piotr J. Chmielewski | Tadeusz Lis | Carlos J. Gómez‐García | Paul M. Zimmerman | Marcin Stępień
Source: Nature Chemistry (article, 2023-10-02)
Field: Materials Science — Materials Chemistry

Tetrafluorenofulvalene as a sterically frustrated open-shell alkene Electronic and steric effects are known to greatly influence the structure, characteristics and reactivity of organic compounds. A typical π bond is weakened by oxidation (corresponding to the removal of electrons from bonding orbitals), by reduction (through addition of electrons to antibonding orbitals) and by unpairing of the bonding electrons, such as in the triplet state. Here we describe tetrafluorenofulvalene (TFF), a twisted, open-shell alkene for which these general rules do not hold. Through the synthesis, experimental characterization and computational analysis of its charged species spanning seven redox states, the central alkene bond in TFF is shown to become substantially stronger in the tri- and tetraanion, generated by chemical reduction. Furthermore, although its triplet state contains a weaker alkene bond than the singlet, in the quintet state its bond order increases substantially, yielding a flatter structure. This behaviour originates from the doubly bifurcated topology of the underlying spin system and can be rationalized by the balancing effects of benzenoid aromaticity and spin pairing. Alkene ; Chemistry ; Antibonding molecular orbital ; Steric effects ; Open shell ; Singlet state ; Atomic orbital ; Bond order ; Computational chemistry ; Reactivity (psychology) ; Chemical physics ; Photochemistry ; Electron ; Crystallography ; Bond length ; Stereochemistry ; Atomic physics ; Crystal structure ; Physics ; Catalysis ; Organic chemistry ; Quantum mechanics Porphyrin and Phthalocyanine Chemistry ; Luminescence and Fluorescent Materials ; Synthesis and Properties of Aromatic Compounds
Authors: Roya Binaymotlagh | Laura Chronopoulou | Cleofe Palocci
Source: Journal of Functional Biomaterials (review, 2023-04-19)
Field: Materials Science — Biomaterials

Peptide-Based Hydrogels: Template Materials for Tissue Engineering Tissue and organ regeneration are challenging issues, yet they represent the frontier of current research in the biomedical field. Currently, a major problem is the lack of ideal scaffold materials' definition. As well known, peptide hydrogels have attracted increasing attention in recent years thanks to significant properties such as biocompatibility, biodegradability, good mechanical stability, and tissue-like elasticity. Such properties make them excellent candidates for 3D scaffold materials. In this review, the first aim is to describe the main features of a peptide hydrogel in order to be considered as a 3D scaffold, focusing in particular on mechanical properties, as well as on biodegradability and bioactivity. Then, some recent applications of peptide hydrogels in tissue engineering, including soft and hard tissues, will be discussed to analyze the most relevant research trends in this field. Self-healing hydrogels ; Biocompatibility ; Tissue engineering ; Scaffold ; Materials science ; Nanotechnology ; Regenerative medicine ; Biodegradation ; Biomedical engineering ; Soft materials ; Regeneration (biology) ; Engineering ; Chemistry Supramolecular Self-Assembly in Materials ; Silk-based biomaterials and applications ; Hydrogels: synthesis, properties, applications
Authors: Xiao Xiao | Xiaoyu Zhao | Xi Chen | Jianzhang Zhao
Source: Molecules (review, 2023-02-26)
Field: Materials Science — Materials Chemistry

Heavy Atom-Free Triplet Photosensitizers: Molecular Structure Design, Photophysical Properties and Application in Photodynamic Therapy Photodynamic therapy (PDT) is a promising method for the treatment of cancer, because of its advantages including a low toxicity, non-drug-resistant character, and targeting capability. From a photochemical aspect, a critical property of triplet photosensitizers (PSs) used for PDT reagents is the intersystem crossing (ISC) efficiency. Conventional PDT reagents are limited to porphyrin compounds. However, these compounds are difficult to prepare, purify, and derivatize. Thus, new molecular structure paradigms are desired to develop novel, efficient, and versatile PDT reagents, especially those contain no heavy atoms, such as Pt or I, etc. Unfortunately, the ISC ability of heavy atom-free organic compounds is usually elusive, and it is difficult to predict the ISC capability of these compounds and design novel heavy atom-free PDT reagents. Herein, from a photophysical perspective, we summarize the recent developments of heavy atom-free triplet PSs, including methods based on radical-enhanced ISC (REISC, facilitated by electron spin-spin interaction), twisted π-conjugation system-induced ISC, the use of fullerene C<sub>60</sub> as an electron spin converter in antenna-C<sub>60</sub> dyads, energetically matched S<sub>1</sub>/T<sub>n</sub> states-enhanced ISC, etc. The application of these compounds in PDT is also briefly introduced. Most of the presented examples are the works of our research group. Photodynamic therapy ; Intersystem crossing ; Reagent ; Chemistry ; Combinatorial chemistry ; Porphyrin ; Photochemistry ; Atom (system on chip) ; Nanotechnology ; Materials science ; Organic chemistry ; Excited state ; Singlet state ; Computer science Luminescence and Fluorescent Materials ; Porphyrin and Phthalocyanine Chemistry ; Nanoplatforms for cancer theranostics