jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Junsha An | Zengmiao Hou | Jiaqi Li | Qing-Fang Bi | Shile Huang | Peng Cheng | Peng Fu
Source: Frontiers in Pharmacology (article, 2025-12-09)
Field: Materials Science — Surfaces, Coatings and Films

Pharmacological effects and application prospects of mussel adhesive proteins Mussel adhesive proteins (MAPs) are natural proteins derived from <i>Mytilus edulis</i>, renowned for their exceptional adhesive properties. These proteins, rich in 3,4-dihydroxyphenylalanine (DOPA) residues, enable mussels to adhere firmly to surfaces in challenging environments. Due to these unique biochemical and mechanical characteristics, MAPs have attracted significant attention in the biomedical field, offering promising applications in wound healing, drug delivery, tissue engineering, and cosmetics. Recombinant MAPs (rMAPs), in particular, hold great potential due to their enhanced properties, including antioxidant, anti-inflammatory, antibacterial, and cell-protective effects. They are increasingly being explored for their role in tissue repair, skin regeneration, and targeted drug delivery systems. Despite challenges in recombinant production, toxicity control, and underwater adhesion efficiency, ongoing advancements in genetic engineering and protein design are expanding the application prospects of rMAPs. This review explores the structure, pharmacological effects, and biomedical applications of MAPs, with a focus on the potential of rMAPs in precision medicine, drug delivery, and tissue regeneration, while highlighting the challenges and future directions for their development. Mussel ; Recombinant DNA ; Drug delivery ; Drug ; Adhesion ; Drug discovery Polymer Surface Interaction Studies ; Surgical Sutures and Adhesives ; Surface Modification and Superhydrophobicity
Authors: Jiale Zou | Siwen Chen | Wen-Hui Liu | Yishu Wang | Diwei Zheng | Wenqiang Sun | Shiping Xu | Wei Wei | Shuang Wang
Source: Nanoscale Horizons (review, 2025-01-01)
Field: Materials Science — Biomaterials

Nanoformulation-based drug delivery systems for the treatment of gastric cancer: recent developments and future prospects Gastric cancer (GC) is one of the leading causes of cancer-related mortality worldwide. Despite significant efforts and recent advances in GC treatment, therapeutic efficacy remains suboptimal. In recent years, emerging nanomaterials have demonstrated considerable potential for cancer therapy, primarily due to their ability to function as drug carriers that enable targeted and precise delivery of therapeutic agents to tumour tissues. This not only increases therapeutic efficacy but also reduces side effects. Herein, we present a comprehensive review of the major types of nanoformulations, including liposomes, albumin-based nanoparticles (NPs), polymer-based NPs, inorganic NPs, and cell-derived nanomaterials. We also examine recently reported nanoformulations for various GC treatment strategies, such as chemotherapy, radiotherapy, immunotherapy, gene therapy, phototherapy, and combined therapy. We highlight the design concepts and principles underlying these nanoformulations employed in GC treatment. Additionally, we discuss the challenges associated with nanoformulation-based treatments for GC as well as future prospects in this rapidly evolving field. Drug delivery ; Cancer ; Drug ; Medicine ; Intensive care medicine ; Pharmacology ; Internal medicine ; Nanotechnology ; Materials science Nanoparticle-Based Drug Delivery ; Peptidase Inhibition and Analysis ; Cancer Mechanisms and Therapy
Authors: Meng Ni | Lin-Xia Zhou | Xiaohua Yang | Ke Wang | Bin Yu | 達也 宮前
Source: Molecular & cellular biomechanics (article, 2025-04-10)
Field: Materials Science — Materials Chemistry

The biomechanical study on the preparation and upconversion luminescence properties and antibacterial performance of Pr&lt;sup&gt;3+&lt;/sup&gt;-doped Y&lt;sub&gt;2&lt;/sub&gt;SiO&lt;sub&gt;5&lt;/sub&gt; based on bivalent ionic Yb&lt;sup&gt;3+&lt;/sup&gt;-Li&lt;sup&gt;+&lt;/sup&gt; This study focuses on the extended applications of Pr3+-doped yttrium oxide single crystals. By introducing Yb2O3, Yb/Pr co-doped Y2SiO5 single crystals and dual-ion Yb3+-Li+ doped Pr3+: Y2SiO5 materials were successfully prepared. Beyond their systematically investigated optical properties, their mechanical properties relevant to biomechanics were also examined. The experiment revealed that Yb3+@Pr3+: Y2SiO5 doped with 0.1 mol% Yb₂O₃ exhibited the highest fluorescence emission (approximately 250,000 cps), with the synergistic effect of Yb3⁺-Li⁺ significantly increasing upconversion efficiency. Under 980 nm far-infrared excitation, the quantum efficiency reached 74.9%, significantly surpassing that of single-ion doping systems. Moreover, under 415 nm visible light excitation, Yb3+@Pr3+: Y2SiO5 exhibited excellent light conversion efficiency (7.52%), highlighting its potential as a light conversion material. The combination of these optical properties with favorable mechanical characteristics underscores its promise as a multifunctional material for biomechanical applications. Dual-ion Li-Yb@Pr3+: Y2SiO5 under 980 nm infrared light irradiation, showed a significantly improved antibacterial effect compared to the control group under dark conditions. The results indicate that this material can better withstand mechanical stress exerted by biological tissues, highlighting its potential for applications in both antibacterial and biomechanical fields. This study not only improves the understanding of the optical and mechanical properties of rare-earth-doped materials in the context of biomechanics but also offers a scientific basis and experimental foundation for their use in implant design. By considering both optical and mechanical properties, as well as biological tissue-material interactions from a mechanical perspective, this work paves the way for advanced materials in biomedical applications. Doping ; Photon upconversion ; Luminescence ; Materials science ; Nuclear chemistry ; Analytical Chemistry (journal) ; Radiochemistry ; Chemistry ; Optoelectronics ; Chromatography Luminescence Properties of Advanced Materials ; Nanoplatforms for cancer theranostics ; Crystal Structures and Properties
Authors: Qingwei Gao | Zhiwei Wei | Zhi‐Min Chen
Source: Beilstein Journal of Organic Chemistry (review, 2025-11-06)
Field: Chemistry — Organic Chemistry

Catalytic enantioselective synthesis of selenium-containing atropisomers via C–Se bond formations Atropisomers are not only prevalent in biologically active natural products and pharmaceuticals, but they have also garnered increasing attention for their effectiveness as ligands and catalysts in the field of catalytic asymmetric synthesis. Asymmetric catalysis serves as a key strategy for the enantioselective synthesis of atropisomers, and significant progress has been made in recent years. However, selenium-containing atropisomers have long remained underexplored as synthetic targets, and only in recent years have they begun to attract increasing attention from the community. Recently, several synthetic approaches for constructing selenium-containing atropisomers have been reported, such as C-H selenylation of arenes, selenosulfonylation of vinylidene <i>o</i>-quinone methides (VQM), and hydroselenation of alkynes. Nevertheless, a comprehensive review that systematically summarizes these advances is currently lacking. This review aims to provide an overview of recent developments in the catalytic enantioselective synthesis of selenium-containing atropisomers via C-Se bond formation. We hope this review will serve as a valuable reference for researchers interested in further exploring this area. Atropisomer ; Enantioselective synthesis ; Catalysis ; Organocatalysis ; Organic synthesis ; Axial chirality Axial and Atropisomeric Chirality Synthesis ; Organoselenium and organotellurium chemistry ; Biological Activity of Diterpenoids and Biflavonoids
Authors: Blessing Nima Xaviour Selvaraj | Mauro Rubén Cushpa Guamán | Preetjot Singh | Deepak Minhas | Manni Sruthi | Shardul Agrawala
Source: Health Leadership and Quality of Life (article, 2025-08-09)
Field: Materials Science — Materials Chemistry

The Role of Nanoparticles in Wound Healing: Synthesis, Characterization, and Mechanisms of Action As a consequence of its distinctive functioning and diverse set of uses, nanotechnology is a discipline that is expanding quickly. To prevent, cure, diagnose, and control illness, nanomedicine examines the potential applications of nanotechnology knowledge and techniques. Silver nanoparticles with a length between 1 to 100 mm are thought to be the most important in this aspect because of their exceptional property, ability that form different nanostructures, incredible group for antibacterial effects, the space for wound healing and other beneficial ability, and efficiency in production. Research analysis the different biological, chemical, and physical techniques for nanoparticles development are explored. The techniques to employ silver nanoparticles as antibacterial substances, anticancer, in dentistry and bone healing promoter, in wound healing supporters are presented. Research examines the purpose of silver nanoparticles in medical therapies and illness management by examining their method of accomplishment, synthesis techniques characterization. Wound healing ; Characterization (materials science) ; Nanoparticle ; Action (physics) ; Nanotechnology ; Materials science ; Medicine ; Surgery ; Physics Nanoparticles: synthesis and applications ; Wound Healing and Treatments ; Medical and Biological Ozone Research
Authors: Tímea R. Kégl | Tamás Kégl
Source: ChemTexts (article, 2025-10-30)
Field: Chemistry — Organic Chemistry

Cavitands: structure, recognition, and function in supramolecular chemistry Abstract Resorcin[4]arenes and related cavitands are bowl-shaped macrocyclic compounds possessing rigid cavities that enable highly selective molecular recognition. In this lecture text, we describe their structural principles, conformational behavior, and electronic properties, alongside key functional applications. Special attention is given to the resorcin[4]arene-based framework, which forms the cornerstone of modern cavitand design. The dynamic vase–kite equilibrium is discussed as a central conformational feature, influencing the host–guest interactions. Through selected examples, we illustrate how fine-tuning the cavitand structure leads to diverse and controllable recognition profiles, underlining their importance in the broader context of supramolecular chemistry. Cavitand ; Supramolecular chemistry ; Context (archaeology) ; Molecular recognition ; Function (biology) ; Key (lock) Supramolecular Chemistry and Complexes ; Crystallography and molecular interactions ; Molecular Sensors and Ion Detection
Authors: Xin Wu | Zhuang Tong | Yunliang Liu | Yi Yang | Yaxi Li | Yuanyuan Cheng | Jingwen Yu | Naiyun Liu | Chanyuan Jin | Haitao Li
Source: Nano Research (article, 2025-02-28)
Field: Materials Science — Materials Chemistry

Cationic carbon dots: A novel class of mimetic enzymes Natural enzymes are highly efficient catalysts with strong substrate specificity, making them ideal for biomedical applications. However, they often face issues such as variability, high costs, challenging preparation processes, and difficulties in large-scale production. This has led to significant efforts in developing effective nanoenzymes and exploring their application potential. In recent years, carbon dots (CDs) have gained attention due to their strong fluorescence, excellent biocompatibility, and low cytotoxicity. Cationic CDs, which possess a positively charged surface, have shown the ability to mimic natural enzyme applications. The positive charge on the surfaces of these nanomaterials significantly influences their fluorescence, biological activity, and interactions with other biomolecules. Therefore, understanding how surface charge affects the performance of CDs is crucial for enhancing their usability. Considerable progress has been made in the design, synthesis, and mechanistic research of enzyme-like cationic CDs, as well as their advanced applications. This article reviews the latest research on the design structure, catalytic mechanisms, biosensing capabilities, and biomedical applications of enzyme-like cationic CDs. First, we review the synthesis strategies for cationic CDs and how surface charge influences their physical and chemical properties. Next, we highlight various applications of these cationic CDs, demonstrating their use in areas such as detection, biomedical applications (including antibacterial agents, gene carriers, and therapeutic agents), catalysis, and more. Finally, we discuss the challenges and obstacles faced in the development of cationic CDs and look forward to exploring new applications in the future. Cationic polymerization ; Carbon fibers ; Class (philosophy) ; Enzyme ; Chemistry ; Materials science ; Nanotechnology ; Polymer chemistry ; Organic chemistry ; Computer science ; Composite number ; Composite material ; Artificial intelligence Carbon and Quantum Dots Applications ; Nanocluster Synthesis and Applications ; Molecular Sensors and Ion Detection
Authors: Alexander J. Steeves | Fabio Variola
Source: Soft Matter (article, 2025-01-01)
Field: Chemistry — Spectroscopy

Chirality and concentration govern polycatecholamine self-assembly: a comparative study of dopamine, levodopa, and norepinephrine Polycatecholamines (pCAs), including poly(dopamine) (pDA), poly(levodopa) (pLD) and poly(norepinephrine) (pNE), hold enormous potential in biomaterials science in the form of functional coatings and particles due to their adhesive and versatile physicochemical properties. However, while pDA has been extensively studied, the potential of pLD and pNE has yet to be fully explored. To bridge this gap, this study provides a comparative analysis of dopamine (DA), levodopa (LD), L-norepinephrine (L-NE), and racemic norepinephrine (rac-NE), focusing on how precursor chemistry, concentration (0.5 <i>vs.</i> 2.0 mg mL<sup>-1</sup>), and NE chirality influence polymerization kinetics and particle formation. By employing dual-wavelength absorbance (450 nm, <i>A</i><sub>450</sub>; 600 nm, <i>A</i><sub>600</sub>) measurements, we revealed distinct concentration-dependent effects, with higher concentrations accelerating monomer-to-intermediate transitions and inducing saturation kinetics. Dynamic light scattering (DLS) highlighted particle size evolution, showing how the zwitterionic character of pLD and chirality in pNE affect stability and size distribution. Additionally, we introduced the polymer dispersion ratio (PDR), a novel metric mapping spatial and temporal aggregate distribution, identifying distinct aggregation and sedimentation patterns. Results from this study underscore the critical role of precursor concentration and chirality in shaping the properties of pCA coatings, namely the temporal evolution of the surface-deposited polymer. Ultimately, this framework informs the synthesis and selection of pCAs for biomedical applications, including functional (<i>e.g.</i>, cell-instructive, antibacterial) coatings with tailored topography for implantable devices, drug-eluting platforms, and bioadhesive technologies, while also translating to broader research areas which could benefit from these findings, such as energy storage and environmental remediation, among others. Chirality (physics) ; Absorbance ; Polymerization ; Polymer ; Dispersion (optics) ; Particle size ; Kinetics ; Particle (ecology) Molecular spectroscopy and chirality ; Neuroscience and Neuropharmacology Research ; Chemical Synthesis and Analysis
Authors: Anirban Das | Ushasi Pramanik | Elise M. Brown | Chih-Yun Liu | Huan Gong | Jonathan Fascetti | Mark Gibson | Samuel Stealey | Silviya P. Zustiak | Cory Berkland | Meredith E. Jackrel | Mark A. White | Jai S. Rudra
Source: bioRxiv (Cold Spring Harbor Laboratory) (preprint, 2025-07-11)
Field: Materials Science — Biomaterials

Substituent-based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides Peptide-based biomaterials assembled through monomer-by-monomer self-assembly provide versatile platforms for biomedical applications due to their adjustable physicochemical properties, biocompatibility, and dynamic nature. The self-assembly process largely depends on primary sequence features, such as hydrophobicity, length, and charge, which influence the formation of various nanostructures, including fibrils and hydrogels. Amphipathic peptides, characterized by alternating polar and hydrophobic residues, are especially effective in forming supramolecular nanofibers stabilized by π-π interactions and hydrogen bonds. Chemical modifications, particularly on aromatic side chains, have proven to be a promising approach for controlling assembly morphology, stability, and biological activity. In organic chemistry, the use of chemical substituents, such as halogens, alkyl groups, or electron-donating and electron-withdrawing groups, has been widely employed to alter reactivity, stability, and molecular interactions for diverse applications, including catalysts, pharmaceuticals, and materials science. However, the influence of these substituents on peptide packing and <i>in vivo</i> immunogenicity remains relatively unexplored. In this study, we systematically examine how changes in the position and nature of substituents on benzyl groups attached to short amphipathic peptides affect self-assembly, fibril morphology, and immune responses. By introducing different electron-donating and withdrawing groups at the para-position of benzyl rings and modifying the chain length connecting the backbone to the aromatic moiety, we observe notable effects on fibril formation, molecular packing, and immunogenicity both <i>in vitro</i> and <i>in vivo</i> . Our results show that subtle chemical modifications are effective tools for designing tailored peptide nanomaterials with promising potential in vaccine delivery, tissue engineering, and regenerative medicine. Immunogenicity ; Substituent ; Amphiphile ; Modulation (music) ; Chemistry ; Stereochemistry ; Immune system ; Biology ; Immunology ; Organic chemistry ; Art ; Aesthetics Supramolecular Self-Assembly in Materials ; Polydiacetylene-based materials and applications ; Lipid Membrane Structure and Behavior
Authors: Yang Yuan | Chang‐Sheng Kuai | Xiao‐Feng Wu
Source: Chemical Communications (article, 2025-12-08)
Field: Chemistry — Organic Chemistry

Turn left and turn right: recent advances in selectivity controlled carbonylation The quest for selectivity is a central theme in modern organic synthesis, aiming to construct complex molecules with precision and efficiency. Transition-metal-catalyzed carbonylation, which utilizes carbon monoxide as an ideal C1 building block, offers a powerful platform for this endeavor. However, the presence of multiple reactive sites or selectivities in a substrate often leads to a mixture of products, posing a significant challenge to synthetic utility. A paramount goal is to develop divergent synthetic methods where a single set of starting materials can be selectively converted into multiple, distinct products by subtle adjustments to the reaction conditions. This review summarizes key advances from 2018 to 2025 that demonstrate how selectivity in carbonylation can be effectively controlled not by the inherent reactivity of the substrate, but by the catalytic system itself. Strategic manipulation of key variables, especially ligand engineering, but also the choice of base, additives, and other conditions, allows precise steering of reaction pathways to turn "left" or "right". These principles have been successfully applied across different substrate classes, including alkenes, alkynes, 1,3-enynes, alcohols, imines, oxime esters, and organohalides, enabling access to structurally diverse products from common starting materials which illustrates a general and tunable approach to divergent synthesis. Carbonylation ; Selectivity ; Carbon monoxide ; Substrate (aquarium) ; Ligand (biochemistry) ; Reactivity (psychology) ; Catalysis Catalytic Cross-Coupling Reactions ; Catalytic C–H Functionalization Methods ; Carbon dioxide utilization in catalysis
Authors: Rasha Diab | Fatima Mahroos | Sreeshna Ravindran | Oussama M. El‐Kadri | Mohammad H. Al‐Sayah
Source: Materials Advances (article, 2025-01-01)
Field: Materials Science — Materials Chemistry

A 3-in-1 multifunctional porous organic polyimide: detection, capture and controlled release of antibacterial drugs Two imide-linked porous organic polymers (POPs), PI-POP and NI-POP, were synthesized and evaluated as multifunctional materials for chemical sensing, adsorption, and temperature-responsive release applications. Polyimide ; Drug ; Porosity ; Materials science ; Nanotechnology ; Pharmacology ; Composite material ; Medicine Covalent Organic Framework Applications ; Synthesis and properties of polymers ; Nanoplatforms for cancer theranostics
Authors: Boaz Bishop | Sahil Sharma | Ratnakar Tiwari | Simseok A. Yuk | Sultan Almunif | Susan E. Quaggin | Evan A. Scott | Pinelopi P. Kapitsinou
Source: Nanoscale Horizons (article, 2025-01-01)
Field: Materials Science — Biomaterials

Enabling organ- and injury-specific nanocarrier targeting <i>via</i> surface-functionalized PEG- <i>b</i> -PPS micelles for acute kidney injury While nanomedicine holds great promise for kidney disease, targeted delivery remains a major challenge. Most nanocarriers rely on passive accumulation or epithelial-specific ligands, limiting their utility in complex, inflamed renal environments. In acute kidney injury (AKI), inflammation and vascular dysfunction play central roles, yet targeting strategies beyond the tubule remain underexplored. Here, dual-ligand micelles are developed to enhance nanocarrier localization to the inflamed kidney by simultaneously engaging both organ- and injury-specific cues. Poly(ethylene glycol)-<i>block</i>-poly(propylene sulfide) (PEG-<i>b</i>-PPS) micelles were engineered to display two peptide ligands: CLPVASC, which preferentially distributes to the kidney, and CYNTTTHRC, which binds selectively to inflamed endothelium. These targeting motifs were incorporated <i>via</i> lipid-anchored peptide amphiphiles, enabling modular surface functionalization without disrupting micelle morphology, size, or charge. <i>In vitro</i>, dual-targeted micelles demonstrated enhanced uptake by human endothelial cells exposed to hypoxia-reoxygenation. <i>In vivo</i>, following unilateral renal ischemia-reperfusion injury (IRI) in mice, targeted micelles achieved selective accumulation in the injured kidney, outperforming both non-targeted controls and contralateral kidneys. Off-target distribution to liver, lung, and spleen was markedly reduced, confirming the spatial precision of the dual-ligand approach. This strategy offers a scalable, modular, and biologically informed platform for precision delivery in AKI and related inflammatory conditions. Nanocarriers ; Micelle ; Acute kidney injury ; Kidney ; Nanomedicine ; Targeted drug delivery ; Inflammation ; Drug delivery Nanoparticle-Based Drug Delivery ; Pharmacological Effects and Toxicity Studies