jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Marco Y. Hein | Duo Peng | Verina Todorova | Frank McCarthy | Kibeom Kim | Chad Liu | Laura Savy | Camille Januel | Rodrigo Baltazar-Nunez | Sophie Bax | Shivanshi Vaid | Madhuri Vangipuram | Ivan E. Ivanov | Janie R. Byrum | Soorya Pradeep | Carlos G. Gonzalez | Yttria Aniseia | Eileen Wang | Joseph S. Creery | Aidan H. McMorrow | James Burgess | Sara Sunshine | Serena Yeung-Levy | Brian C. DeFelice | Shalin B. Mehta | Daniel N. Itzhak | Joshua E. Elias | Manuel D. Leonetti
Source: bioRxiv (Cold Spring Harbor Laboratory) (preprint, 2023-12-18)
Field: Chemistry — Spectroscopy

Global organelle profiling reveals subcellular localization and remodeling at proteome scale ABSTRACT Defining the subcellular distribution of all human proteins and its remodeling across cellular states remains a central goal in cell biology. Here, we present a high-resolution strategy to map subcellular organization using organelle immuno-capture coupled to mass spectrometry. We apply this proteomics workflow to a cell-wide collection of membranous and membrane-less compartments. A graph-based representation of our data reveals the subcellular localization of over 7,600 proteins, defines spatial protein networks, and uncovers interconnections between cellular compartments. We demonstrate that our approach can be deployed to comprehensively profile proteome remodeling during cellular perturbation. By characterizing the cellular landscape following hCoV-OC43 viral infection, we discover that many proteins are regulated by changes in their spatial distribution rather than by changes in their total abundance. Our results establish that proteome-wide analysis of subcellular remodeling provides essential insights for the elucidation of cellular responses. Our dataset can be explored at organelles.czbiohub.org . Proteome ; Organelle ; Subcellular localization ; Proteomics ; Protein subcellular localization prediction ; Biology ; Computational biology ; Cellular compartment ; Cell biology ; Quantitative proteomics ; Systems biology ; Cell ; Bioinformatics ; Biochemistry ; Gene ; Cytoplasm Advanced Proteomics Techniques and Applications ; Biotin and Related Studies ; Bioinformatics and Genomic Networks
Authors: Shaimaa A. Ahmed | Aida A. Salama | Mohamed H. Gaber | Said A. Ali
Source: Journal of Pharmaceutical Innovation (article, 2023-05-09)
Field: Materials Science — Biomaterials

Development and Characterization of Soy Lecithin Liposome as Potential Drug Carrier Systems for Doxorubicin Abstract Purpose The phospholipids from plant origins play an important role in different techniques, especially in drug delivery applications. The purpose of this study is to investigate the effect of liposomes prepared from plant origin as a cheap source of lipids as drug carriers. Methods Soy lecithin liposomes (SLP) were prepared and loaded with doxorubicin (DOX) to use as a drug delivery system. DOX was used as the model drug and DOX/SLP was successfully combined. The characteristics of these liposomes, zeta potential, size distribution, drug encapsulation efficiency (EE%), drug release, Fourier transform infrared (FTIR), and transmission electron microscopy (TEM) were checked followed by in vitro study. The cytotoxicity study by using free DOX and DOX/SLP is done on Mcf-7, human breast cancer as a cell line. Results The optimal DOX/SLP formulation had a mean size of 342 nm, a negative zeta potential of −22.3 mV, the loaded DOX/SLP showed EE% (83.68%), and a drug release profile of 35 h, all are recorded. Cytotoxicity assay showed that the IC 50 of DOX/SLP is smaller than that of free DOX. Conclusion These results give evidence of the efficacy of using drug carriers from plant origin combined with drugs to increase the effective therapies against cancer medically and economically. Graphical Abstract Zeta potential ; Liposome ; Doxorubicin ; Cytotoxicity ; Pharmacology ; Drug ; Drug delivery ; Chemistry ; Lecithin ; Drug carrier ; Chromatography ; In vitro ; Materials science ; Nanotechnology ; Nanoparticle ; Chemotherapy ; Biochemistry ; Medicine ; Organic chemistry ; Surgery Nanoparticle-Based Drug Delivery ; Lipid Membrane Structure and Behavior ; Advanced NMR Techniques and Applications
Authors: Agusril Syamsir | Lee Woen Ean | M. R. M. Asyraf | Mohd Supian Abu Bakar | Emrah Madenci | Yasin Onuralp Özkılıç | Ceyhun Aksoylu
Source: Materials (review, 2023-03-30)
Field: Materials Science — Polymers and Plastics

Recent Advances of GFRP Composite Cross Arms in Energy Transmission Tower: A Short Review on Design Improvements and Mechanical Properties Currently, pultruded glass fibre-reinforced polymer (pGFRP) composites have been extensively applied as cross-arm structures in latticed transmission towers. These materials were chosen for their high strength-to-weight ratio and lightweight characteristics. Nevertheless, several researchers have discovered that several existing composite cross arms can decline in performance, which leads to composite failure due to creep, torsional movement, buckling, moisture, significant temperature change, and other environmental factors. This leads to the composite structure experiencing a reduced service life. To resolve this problem, several researchers have proposed to implement composite cross arms with sleeve installation, an addition of bracing systems, and the inclusion of pGFRP composite beams with the core structure in order to have a sustainable composite structure. The aforementioned improvements in these composite structures provide superior performance under mechanical duress by having better stiffness, superiority in flexural behaviour, enhanced energy absorption, and improved load-carrying capacity. Even though there is a deficiency in the previous literature on this matter, several established works on the enhancement of composite cross-arm structures and beams have been applied. Thus, this review articles delivers on a state-of-the-art review on the design improvement and mechanical properties of composite cross-arm structures in experimental and computational simulation approaches. Composite number ; Structural engineering ; Pultrusion ; Materials science ; Stiffness ; Flexural strength ; Fibre-reinforced plastic ; Composite material ; Philosophy of design ; Buckling ; Engineering Natural Fiber Reinforced Composites ; Structural Analysis and Optimization ; Structural Behavior of Reinforced Concrete
Authors: R. Gobinath | V. Mahesh | Naraindas Bheel | Sampada Chittimalla | Katakam Srihitha | Alamadri Sushmasree
Source: Buildings (article, 2023-05-11)
Field: Materials Science — Polymers and Plastics

Usage of Natural Fibre Composites for Sustainable Material Development: Global Research Productivity Analysis Natural-fibre-reinforced composites (NFRCs) are revolutionising the way materials are used for various purposes, and they have enriched applications from aerospace to concrete. In tandem with these works, sustainable materials that are eco-friendly and possess strength and endurance are rapidly replacing conventional materials. Recent decades have shown that many exuberant, curious-minded researchers are working on this particular domain, creating numerous materials for a variety of applications. What exactly is being performed in the laboratory is not being carried out in the field and duly disseminated. The major constraint is knowledge sharing and bottlenecks involved in assessing that research. Scientometrics is a field providing access to the consolidated research landscape report on a particular topic informing research on what work is being performed, how it is performed, who performs it, and what is the future scope. In this work, we analyse the research works, trends, and challenges related to NFRCs for engineering applications. It is found that research works, and the utilisation related to NFRCs, have soared in the last two decades, which proves to be a promising area to work upon. We use the Scopus database for the analysis, and scientometric analysis is carried over with biblioshiny. We find that there is a decreasing trend in publications (−12.74%/year); 272 sources are involved with 1690 documents published containing 5554 authors with 54 single-authored documents. There are 3919 keywords involved with 16.51 average citations received for the documents published. This work can be used to understand the research trend and also to take up newer research. Scopus ; Scientometrics ; Scope (computer science) ; Productivity ; Work (physics) ; Aerospace ; Computer science ; Bibliometrics ; Citation analysis ; Data science ; Architectural engineering ; Engineering ; World Wide Web ; Citation ; Mechanical engineering ; Political science Natural Fiber Reinforced Composites ; Additive Manufacturing and 3D Printing Technologies
Authors: Fuyin Luo | Chuanliang Li | Xiaohu He
Source: Physica Scripta (article, 2023-10-19)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Ultra-wideband and wide-angle metamaterial absorber for solar energy harvesting from ultraviolet to near infrared Abstract In this paper, an ultra-wideband solar absorber consisting of a four-layer structure of Al 2 O 3 -TiN-Al 2 O 3 -Ti is proposed. The proposed absorber achieves an average absorption of 97.85% in the wavelength range of 250–2000 nm (49.96% improvement over the reference planar structure), and its bandwidth of absorption over 90% is even as high as 1742 nm. As a result of the symmetrical design of the structure, the absorber has polarization insensitivity and wide-angle absorption characteristics. In particular, the absorber has a large process tolerance in the structural parameters and a high degree of universality for other metals and dielectric materials, which is highly advantageous in manufacturing. In addition, we explored the reasons for the high absorption of the structure in detail, discussed the influence of different structures on the absorption, and analyzed the absorption characteristics and thermal conversion efficiency of the structure under the solar spectrum. The proposed structure provides a broader bandwidth and higher light absorption than the recently reported work and further reduces the structure’s thickness. Therefore, the absorber will have broad application prospects in photothermal conversion, solar cells, imaging, and stealth. Materials science ; Metamaterial absorber ; Optoelectronics ; Wideband ; Absorption (acoustics) ; Metamaterial ; Optics ; Polarization (electrochemistry) ; Ultraviolet ; Microwave ; Dielectric ; Planar ; Physics ; Composite material ; Computer science ; Chemistry ; Telecommunications Metamaterials and Metasurfaces Applications ; Advanced Antenna and Metasurface Technologies ; Thermal Radiation and Cooling Technologies
Authors: Ana M. Jiménez–Carvelo | Alejandra Arroyo-Cerezo | Luis Cuadros-Rodrı́guez
Source: TrAC Trends in Analytical Chemistry (article, 2023-11-30)
Field: Chemistry — Analytical Chemistry

Evaluating the whiteness of spectroscopy-based non-destructive analytical methods – Application to food analytical control Recent advancements in analytical chemistry in the food quality field have emphasized ecofriendly analytical techniques eschewing chemicals and solvents. Various methodologies exist for assessing the sustainability of analytical methods, however none has provided guidance for appraising non-destructive methods, especially pre-development. Among these, the RGB approach stands out, evaluating method colour via three main criteria: analytical performance, environmental impact, and practical efficiency. This framework offers a comprehensive evaluation, aiming for a "white" colour denoting excellence across all three categories. This article introduces an adapted RGB method for ex-ante evaluation of new non-destructive analytical methods pre-development. It outlines key steps for evaluating method "whiteness". As a guiding example, the approach was applied to three analytical methods focussed on quality and authenticity control of edible vegetable oils utilizing solvent-free spectroscopic techniques. Results underscored a priori feasibility assessment value, aligning evaluative objectives with intended method goals. Computer science ; Sustainability ; Quality (philosophy) ; Biochemical engineering ; Field (mathematics) ; Management science ; Engineering ; Mathematics Spectroscopy and Chemometric Analyses ; Water Quality Monitoring and Analysis ; Advanced Chemical Sensor Technologies
Authors: N. Milani | Eric van Gilst | Bob W.J. Pirok | Peter J. Schoenmakers
Source: Journal of Separation Science (review, 2023-08-31)
Field: Chemistry — Spectroscopy

Comprehensive two‐dimensional gas chromatography— A discussion on recent innovations Although comprehensive 2‐D GC is an established and often applied analytical method, the field is still highly dynamic thanks to a remarkable number of innovations. In this review, we discuss a number of recent developments in comprehensive 2‐D GC technology. A variety of modulation methods are still being actively investigated and many exciting improvements are discussed in this review. We also review interesting developments in detection methods, retention modeling, and data analysis. Variety (cybernetics) ; Computer science ; Field (mathematics) ; Biochemical engineering ; Management science ; Data science ; Nanotechnology ; Engineering ; Materials science ; Artificial intelligence ; Mathematics Analytical Chemistry and Chromatography ; Advanced Chemical Sensor Technologies ; Chromatography in Natural Products
Authors: Claire Koenig | Ana Martínez‐Val | Previn Naicker | Stoyan Stoychev | Justin Jordaan | Jesper V. Olsen
Source: STAR Protocols (article, 2023-09-01)
Field: Chemistry — Spectroscopy

Protocol for high-throughput semi-automated label-free- or TMT-based phosphoproteome profiling Tandem mass tags data-dependent acquisition (TMT-DDA) as well as data-independent acquisition-based label-free quantification (LFQ-DIA) have become the leading workflows to achieve deep proteome and phosphoproteome profiles. We present a modular pipeline for TMT-DDA and LFQ-DIA that integrates steps to perform scalable phosphoproteome profiling, including protein lysate extraction, clean-up, digestion, phosphopeptide enrichment, and TMT-labeling. We also detail peptide and/or phosphopeptide fractionation and pre-mass spectrometry desalting and provide researchers guidance on choosing the best workflow based on sample number and input. For complete details on the use and execution of this protocol, please refer to Koenig et al.<sup>1</sup> and Martínez-Val et al.<sup>2</sup>. Phosphopeptide ; Computer science ; Tandem mass tag ; Proteome ; Workflow ; Profiling (computer programming) ; Tandem mass spectrometry ; Phosphoproteomics ; Computational biology ; Mass spectrometry ; Proteomics ; Quantitative proteomics ; Chemistry ; Bioinformatics ; Chromatography ; Peptide ; Database ; Operating system ; Biology ; Protein phosphorylation Advanced Proteomics Techniques and Applications ; Mass Spectrometry Techniques and Applications ; Genomics and Phylogenetic Studies
Authors: Qiaoyun Wang | Shunyuan Xu | Ziheng Zhu | Jilong Wang | Xin Zou | Chu Zhang | Qiang Liu
Source: Photoacoustics (article, 2023-12-30)
Field: Chemistry — Spectroscopy

High sensitivity and ultra-low concentration range photoacoustic spectroscopy based on trapezoid compound ellipsoid resonant photoacoustic cell and partial least square A high sensitivity and ultra-low concentration range photoacoustic spectroscopy (PAS) gas detection system, which was based on a novel trapezoid compound ellipsoid resonant photoacoustic cell (TCER-PAC) and partial least square (PLS), was proposed to detect acetylene (C<sub>2</sub>H<sub>2</sub>) gas. In the concentration range of 0.5 ppm ∼ 10.0 ppm, the limit of detection (LOD) values of TCER-PAC-based PAS system without data processing was 66.4 ppb, which was lower than that of the traditional trapezoid compound cylindrical resonant photoacoustic cell (TCCR-PAC). The experimental results indicated that the TCER-PAC had higher sensitivity than of TCCR-PAC. Within the concentration range of 12.5 ppb ∼ 125.0 ppb, the LOD and limit of quantification (LOQ) of TCER-PAC-based PAS system combined with PLS regression algorithm were 1.1 ppb and 3.7 ppb, respectively. The results showed that higher detection sensitivity and lower LOD were obtained by PAS system with TCER-PAC and PLS than that of TCCR-PAC-based PAS system. Detection limit ; Photoacoustic spectroscopy ; Photoacoustic imaging in biomedicine ; Analytical Chemistry (journal) ; Sensitivity (control systems) ; Materials science ; Chemistry ; Spectroscopy ; Acetylene ; Chromatography ; Optics ; Physics ; Electronic engineering Spectroscopy and Laser Applications ; Advanced Chemical Sensor Technologies ; Gas Sensing Nanomaterials and Sensors
Authors: Qiao Luo | Ni Shao | Ai-Chen Zhang | Chunfang Chen | Duo Wang | Liangping Luo | Zeyu Xiao
Source: Pharmaceuticals (review, 2023-02-07)
Field: Materials Science — Materials Chemistry

Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges New nanotechnologies for imaging molecules are widely being applied to visualize the expression of specific molecules (e.g., ions, biomarkers) for disease diagnosis. Among various nanoplatforms, nanozymes, which exhibit enzyme-like catalytic activities in vivo, have gained tremendously increasing attention in molecular imaging due to their unique properties such as diverse enzyme-mimicking activities, excellent biocompatibility, ease of surface tenability, and low cost. In addition, by integrating different nanoparticles with superparamagnetic, photoacoustic, fluorescence, and photothermal properties, the nanoenzymes are able to increase the imaging sensitivity and accuracy for better understanding the complexity and the biological process of disease. Moreover, these functions encourage the utilization of nanozymes as therapeutic agents to assist in treatment. In this review, we focus on the applications of nanozymes in molecular imaging and discuss the use of peroxidase (POD), oxidase (OXD), catalase (CAT), and superoxide dismutase (SOD) with different imaging modalities. Further, the applications of nanozymes for cancer treatment, bacterial infection, and inflammation image-guided therapy are discussed. Overall, this review aims to provide a complete reference for research in the interdisciplinary fields of nanotechnology and molecular imaging to promote the advancement and clinical translation of novel biomimetic nanozymes. Molecular imaging ; Nanotechnology ; Photothermal therapy ; Photoacoustic imaging in biomedicine ; Biocompatibility ; Computer science ; Materials science ; Chemistry ; In vivo ; Biology ; Biotechnology Advanced Nanomaterials in Catalysis ; Nanoplatforms for cancer theranostics ; Advanced biosensing and bioanalysis techniques
Authors: Shadeera Rouf | Yaser E. Greish | Bart Van der Bruggen | Sulaiman Al‐Zuhair
Source: Carbon Resources Conversion (article, 2023-09-20)
Field: Chemistry — Inorganic Chemistry

Surface modification of HKUST-1 for enhanced activity of immobilized formate dehydrogenase used in CO2 hydrogenation Post synthetic modification of a hydrophilic metal–organic framework (MOF), HKUST-1, with stearic acid (SA) was carried out to enhance the stability of HKUST-1 in aqueous solution to be used as a support for formate dehydrogenase (FDH) used for CO2 conversion to formate. SA modification improved the hydrophobicity without affecting the morphology and crystal structure of MOF. Adsorption of FDH on the modified MOF (SA@HKUST-1) was compared to that of the native HKUST-1 and ZIF-L. The adsorption kinetics on all MOFs was found to follow pseudo-second order kinetics and the isotherm was best described by Freundlich model. The high stability of SA@HKUST-1 and enhanced hydrophobic interaction between support and CO2 resulted in high catalytic efficiency and stability of FDH@SA@HKUST-1. The immobilized enzyme retained 95.1% of its initial activity after 4 cycles of repeated use. It was also shown that FDH@SA@HKUST-1 retained morphology and crystal structure after repeated use. Results of the present work provide novel insight into the influence of hydrophobic MOFs on the activity and stability of immobilized FDH. These findings are expected to assist in developing highly active and stable biocatalysts for CO2 hydrogenation at commercial level. Formate ; Adsorption ; Formate dehydrogenase ; Aqueous solution ; Chemical engineering ; Kinetics ; Materials science ; Chemistry ; Surface modification ; Catalysis ; Organic chemistry ; Physical chemistry Metal-Organic Frameworks: Synthesis and Applications ; Carbon dioxide utilization in catalysis ; Carbon Dioxide Capture Technologies
Authors: Assia Ben Amor | Marina Arenas | Julia Martı́n | Abdelkader Ouakouak | Juan Luís Santos | Irene Aparicio | Esteban Alonso | Noureddine Hamdi
Source: Chemosphere (article, 2023-05-31)
Field: Materials Science — Biomaterials

Alginate/geopolymer hybrid beads as an innovative adsorbent applied to the removal of 5-fluorouracil from contaminated environmental water Water contaminated by cytostatic drugs has many negative impacts on the ecosystems. In this work, cross-linked adsorbent beads based on alginate and a geopolymer (prepared from an illito-kaolinitic clay) were developed for a promising decontamination of the 5-fluorouracil (5-FU) cytostatic drug from water samples. The characterization of the prepared geopolymer and its hybrid derivative was performed by scanning electron microscopy, X-ray diffraction, Fourier transform infrared and termogravimetric analysis. Batch adsorption experiments indicated that alginate/geopolymer hybrid beads (AGHB) allow an excellent 5-FU removal efficiency of up to 80% for a dosage adsorbent/water of 0.002 g/mL and a concentration of 5-FU of 2.5 mg/L. The adsorption isotherms data follow well the Langmuir model. The kinetics data favor the pseudo-second-order model. The maximum adsorption capacity (q<sub>max</sub>) was 6.2 mg/g. The optimal adsorption pH was 4. Besides pore filling sorption process, the carboxyl and hydroxyl groups from alginate immobilized onto the geopolymer matrix favored the retention of 5-FU ions by hydrogen bonds. Common competitors, such as dissolved organic matter, do not significantly affected the adsorption. In addition, this material has not only eco-friendly and cost-effective advantages but also excellent efficiency when applied to real environmental samples such as wastewater and surface water. This fact suggests that it could have a great application in the purification of contaminated water. Adsorption ; Geopolymer ; Sorption ; Langmuir adsorption model ; Wastewater ; Chemistry ; Fourier transform infrared spectroscopy ; Chemical engineering ; Water treatment ; Nuclear chemistry ; Materials science ; Organic chemistry ; Waste management Clay minerals and soil interactions ; Chemical Synthesis and Characterization ; Adsorption and biosorption for pollutant removal