jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Rajesh Kumar Chawla* and Naresh Ambekar
Source: International Journal of Pharmacy and Life Sciences (article, 2025-01-01)
Field: Chemistry — Analytical Chemistry

A Comprehensive review of Analytical Quality by Design, ICH Q14, and design of experiments in pharmaceutical Analysis: A Synergistic Paradigm for enhanced quality and regulatory efficiency In the modern pharmaceutical landscape, the demand for robust, reliable, and efficient analytical methods is paramount. This manuscript provides a comprehensive review of three interconnected paradigms that are fundamentally reshaping pharmaceutical analysis: Analytical Quality by Design (AQbD), the ICH Q14 guideline on Analytical Procedure Development, and the application of Design of Experiments (DoE). Historically, analytical method development followed a trial-and-error approach, often leading to methods that were fragile, poorly understood, and difficult to transfer. This reactive paradigm is being superseded by a proactive, science- and risk-based approach. AQbD establishes a structured framework for building quality into an analytical procedure from the outset, moving beyond simple compliance to a state of enhanced method understanding and robust performance. ICH Q14 formalizes this approach within a global regulatory context, providing a clear pathway for a structured development process, a well-defined Analytical Target Profile (ATP), and a lifecycle management strategy for analytical procedures. Simultaneously, DoE serves as a critical statistical tool, enabling the systematic exploration of method parameters and their interactions, thereby facilitating the identification of a robust operating design space. This review explores the foundational principles of each paradigm, detailing their core components and objectives. It then delves into their synergistic integration, demonstrating how DoE is the key enabler for implementing an AQbD strategy as outlined by ICH Q14. Practical applications and case studies from various analytical techniques, such as chromatography and spectroscopy, are presented to illustrate the tangible benefits, including improved method ruggedness, reduced method transfer failures, and streamlined post-approval changes. Finally, this review discusses the challenges in implementing this synergistic approach, proposes solutions, and offers a glimpse into future perspectives, highlighting the potential for automation, advanced data analytics, and continuous improvement in analytical procedures. This integrated paradigm represents a crucial evolution in analytical science, promising to enhance product quality, accelerate drug development, and foster greater regulatory efficiency. Quality by Design ; Quality (philosophy) ; Enabling ; Key (lock) ; Identification (biology) ; Design of experiments Analytical Methods in Pharmaceuticals ; Pesticide Residue Analysis and Safety ; Computational Drug Discovery Methods
Authors: Chrystelle Egger | John G. Hardy | Tim Doggett | Katie Dryden-Holt
Source: New Directions in the Teaching of Natural Sciences (article, 2025-06-26)
Field: Chemistry — Physical and Theoretical Chemistry

Bridging the skills gap in chemical sciences to train the next generation workforce Chemistry is an inherently vocational discipline that sits at the interface of science, technology, engineering, mathematics, and medicine (STEMM) subjects (and those aligned with or informed by STEMM subjects). This article probes the perceptions of leadership in industry and higher education institutions (HEIs) in the UK and Ireland of the skills necessary for the next generation workforce, drawing conclusions regarding curriculum design and beyond. Bridging (networking) ; Workforce ; Computer science ; Engineering physics ; Medical education ; Engineering ; Medicine ; Economics ; Economic growth Various Chemistry Research Topics ; Health and Medical Research Impacts
Authors: Rajesh Kumar Chawla* and Naresh Ambekar
Source: International Journal of Pharmacy and Life Sciences (review, 2025-09-28)
Field: Chemistry — Analytical Chemistry

A Comprehensive review of Analytical Quality by Design, ICH Q14, and design of experiments in pharmaceutical Analysis: A Synergistic Paradigm for enhanced quality and regulatory efficiency In the modern pharmaceutical landscape, the demand for robust, reliable, and efficient analytical methods is paramount. This manuscript provides a comprehensive review of three interconnected paradigms that are fundamentally reshaping pharmaceutical analysis: Analytical Quality by Design (AQbD), the ICH Q14 guideline on Analytical Procedure Development, and the application of Design of Experiments (DoE). Historically, analytical method development followed a trial-and-error approach, often leading to methods that were fragile, poorly understood, and difficult to transfer. This reactive paradigm is being superseded by a proactive, science- and risk-based approach. AQbD establishes a structured framework for building quality into an analytical procedure from the outset, moving beyond simple compliance to a state of enhanced method understanding and robust performance. ICH Q14 formalizes this approach within a global regulatory context, providing a clear pathway for a structured development process, a well-defined Analytical Target Profile (ATP), and a lifecycle management strategy for analytical procedures. Simultaneously, DoE serves as a critical statistical tool, enabling the systematic exploration of method parameters and their interactions, thereby facilitating the identification of a robust operating design space. This review explores the foundational principles of each paradigm, detailing their core components and objectives. It then delves into their synergistic integration, demonstrating how DoE is the key enabler for implementing an AQbD strategy as outlined by ICH Q14. Practical applications and case studies from various analytical techniques, such as chromatography and spectroscopy, are presented to illustrate the tangible benefits, including improved method ruggedness, reduced method transfer failures, and streamlined post-approval changes. Finally, this review discusses the challenges in implementing this synergistic approach, proposes solutions, and offers a glimpse into future perspectives, highlighting the potential for automation, advanced data analytics, and continuous improvement in analytical procedures. This integrated paradigm represents a crucial evolution in analytical science, promising to enhance product quality, accelerate drug development, and foster greater regulatory efficiency. Quality by Design ; Quality (philosophy) ; Enabling ; Key (lock) ; Identification (biology) ; Design of experiments Analytical Methods in Pharmaceuticals ; Pesticide Residue Analysis and Safety ; Computational Drug Discovery Methods
Authors: Fatimah M. Alamri | Sultan K. Alshmmari | Monerah Altamimy | Ibrahim A. Al Othaim | Yahya M. Alshehri | Rayed M. Alafraa | Ahmed M. Almalki | Turki A. Alkhalifah | Taher Sahlabji | Abubakr M. Idris | Haitham Al-Hamoud | Yahya F. Jamous | Fahad S. Aldawasri
Source: Frontiers in Chemistry (article, 2025-07-23)
Field: Chemistry — Analytical Chemistry

Investigation of illicit pregabalin in seized samples from Saudi Arabia These results demonstrate significant variability in PGL content and the presence of adulterants, underscoring the need for robust analytical methods in forensic chemistry. Furthermore, the LC-MS/MS method detected adulteration of PGL with codeine, paracetamol, and gabapentin in 2.9% of the analyzed capsules, suggesting custom mixing by perpetrators. In general, 31.43% of these samples failed to meet quality standards and contained substances beyond declared contents that posed toxicity risks, revealing inadequacies in illicit drug production and circulation. The UPLC-PDA method offers a rapid, validated approach for PGL quantification, while LC-MS/MS enhances adulterant detection, supporting forensic and quality control applications. Chromatography ; Pregabalin ; Codeine ; Chemistry ; High-performance liquid chromatography ; Liquid chromatography–mass spectrometry ; Mass spectrometry ; Medicine ; Pharmacology ; Anesthesia ; Morphine Analytical Methods in Pharmaceuticals ; Forensic Toxicology and Drug Analysis ; Opioid Use Disorder Treatment
Authors: Liwen Xie | Fangxue Hang | Debao Niu | Kai Li | Yougen Hu | Fukang Deng
Source: Nano Research (article, 2025-12-01)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Advances in two-dimensional transition metal dichalcogenide nanocomposites for electromagnetic interference shielding: A review With the rapid advancement of the electronics industry, the demand for new EMI shielding materials has grown substantially in recent decades. In response, a wide range of novel materials are being investigated as alternatives to conventional metals. Consequently, lightweight EMI shielding materials designed for miniaturized and highly integrated electronic devices have attracted increasing attention. Two-dimensional (2D) transition metal dichalcogenides (TMDs) offer several advantages—such as excellent thermal and chemical stability, tunable electrical conductivity, unique layered structures, and ultrathin thickness—making them promising candidates for EMI shielding. This review summarizes recent advances in TMDs and their nanocomposites for EMI shielding, highlighting synthesis strategies and offering in-depth analysis of shielding effectiveness, thickness, flexibility, and underlying mechanisms. In addition, the current challenges and future prospects of TMD-based EMI shielding materials are discussed. EMI ; Electromagnetic shielding ; Electromagnetic interference ; Electronics ; Nanocomposite Electromagnetic wave absorption materials ; MXene and MAX Phase Materials ; Aluminum Alloys Composites Properties
Authors: Fatemeh Amirzadeh-Ghasemi | Shahla Roudbar Mohammadi | Ismaeil Haririan
Source: Research Square (preprint, 2025-10-30)
Field: Materials Science — Biomaterials

Electrospun Chitosan/PVA/CNT Nanofiber Composite for Sustained Fluconazole Delivery Against Biofilm-Forming Candida albicans Fluconazole ; Nanofiber ; Candida albicans ; Biofilm ; Antifungal ; MTT assay ; Cytotoxicity ; Drug delivery Electrospun Nanofibers in Biomedical Applications ; Silymarin and Mushroom Poisoning ; Medical and Biological Ozone Research
Authors: Yuan Chen | Naruki Shoji | Hideharu Takahashi | Hiroshige Kikura
Source: Progress in Nuclear Science and Technology (article, 2025-03-31)
Field: Materials Science — Materials Chemistry

Fundamental research on the integrated measurement method using laser and ultrasound for fuel debris investigation This study hopes to combine LIBS technology and ultrasound technology to quickly obtain the distribution, shape, and surface elemental composition of nuclear fuel debris in PCVs.In this paper, the working principle and the construction of the remote LIBS system are described.The operating principles of ultrasound systems for shape and solid-liquid surface distinction measurements are introduced.Then, the remote LIBS and ultrasound systems are integrated to develop an elemental mapping system.The validation experiment of the elemental mapping system is carried out on the simulated nuclear fuel debris.The elemental mapping system successfully obtained a 3D elemental map containing information on the simulated nuclear fuel debris samples' position, shape, and surface elemental composition.Finally, the shape measurement result from the ultrasound system was optimized using the elemental measurement result from the remote LIBS system.Through the validation experiment, it can be seen that the use of ultrasound measurements helps to obtain information about the shape and position and predict the solid and liquid surfaces of the simulated fuel debris simultaneously.This dramatically improves the efficiency of remote LIBS measurements.The application of the remote LIBS system can effectively measure elemental composition on the surface of simulated nuclear fuel debris.Meanwhile, the microchip LIBS system can optimize the shape measurement results of the ultrasound system.Therefore, integrating the two systems allows for more efficient and accurate measurement of nuclear fuel debris' shape, position, and surface elemental composition. Debris ; Laser ; Ultrasound ; Environmental science ; Nuclear engineering ; Computer science ; Optics ; Acoustics ; Physics ; Engineering ; Meteorology Nuclear Materials and Properties ; Forensic Fingerprint Detection Methods ; Fire Detection and Safety Systems
Authors: Jia‐Le Zhang | Sheng Yong | Jie Li | Yueyi Wang | Ling Xu | Gan‐Ji Zhong | Ding‐Xiang Yan | Zhong‐Ming Li
Source: Nano Research (article, 2025-12-12)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Mild alkaline-assisted silver deposition on PLA fibers for ultra-high and sustainable electromagnetic interference shielding The proliferation of electromagnetic spectrum applications and increasing integration density of electronic devices have intensified electromagnetic pollution, driving demand for advanced electromagnetic interference (EMI) shielding materials. While conductive polymer composites present promising alternatives to traditional metals, attaining both exceptional EMI shielding performance and environmental sustainability remains challenging. Here, we adopt controlled mild alkaline hydrolysis to precisely engineer the surface roughness and hydrophilicity of polylactic acid (PLA) fibers, generating optimal substrates for subsequent electroless silver (Ag) deposition. The resulting Ag/PLA conductive fibers are structured into flexible films through vacuum filtration and hot-pressing. These films demonstrate remarkable electrical conductivity of 102,270 S/m, attributed to the continuous Ag coating and three-dimensional fibrous conductive network. Despite a thickness of merely 66 μm, the Ag/PLA films exhibit an ultra-high EMI shielding effectiveness (EMI SE) of 101.0 dB and a specific shielding effectiveness of 9,749.4 dB·cm<sup>2</sup> g<sup>-1</sup>. Notably, the films maintain military-grade EMI shielding performance (&gt;90 dB) after thermal cycling across a ~300 <sup>o</sup>C temperature range and 5,000 bending cycles, confirming superior durability and mechanical flexibility. By synergistically coupling biodegradable PLA with recoverable Ag, this work simultaneously achieves outstanding EMI shielding performance and environmental sustainability, providing valuable insights for developing next-generation green EMI protection materials. Electromagnetic shielding ; Polylactic acid ; Electromagnetic interference ; EMI ; Electrical conductor ; Coating ; Electronics ; Flexible electronics Electromagnetic wave absorption materials ; Electromagnetic Fields and Biological Effects ; Natural Fiber Reinforced Composites
Authors: Xiaoling Zhu | CheongCheon Lee | Ju Hyun Park | Eun Min Go | Suha Cho | Jonghwi Lee | Sang Kyu Kwak | Jaehyeong Bae | Tae Seok Seo
Source: Pharmaceutics (article, 2025-08-09)
Field: Materials Science — Materials Chemistry

Two-Step Nucleation and Amorphization of Carbamazepine Using a Micro-Droplet Precipitation System <b>Objectives</b>: Transforming poorly soluble crystalline drugs into their amorphous form is a well-established strategy in pharmaceutical science to enhance their solubility and improve their clinical efficacy. However, developing amorphous forms of organic drugs for pharmaceutical applications presents significant technical hurdles due to the lack of suitable analytical tools for the amorphization process. Carbamazepine is a crystalline BCS class II drug commonly used for epilepsy and trigeminal neuralgia, whose clinical efficacy is compromised by its low solubility and slow dissolution. Therefore, this study focuses on investigating the amorphization of carbamazepine to enhance its solubility by using a micro-droplet precipitation system. <b>Methods</b>: These micro-droplets serve as individual reactors, enabling homogeneous nucleation for precipitation of carbamazepine. During crystallization, carbamazepine undergoes an intermediate liquid-liquid phase transition characteristic of two-step nucleation. By varying the solvent's composition (methanol/water), we characterized the kinetics and stability of the intermediate liquid phase under various conditions. <b>Results</b>: Our results indicate that carbamazepine can undergo either a one-step liquid-to-amorphous-solid phase transition or a two-step liquid-to-crystalline-solid phase transition. Notably, both transitions pass through a liquid-to-dense-liquid phase separation process starting from the supersaturated solution, where the generated intermediate phases exhibit different sizes and numbers that are influenced by the solvent and its concentration. <b>Conclusions</b>: Our findings not only elucidate the mechanism underlying the carbamazepine phase transition but also propose a novel method for studying the amorphous process, which could be broadly applicable to other poorly soluble pharmaceutical compounds and may be helpful to amorphous formulations production, potentially offering significant improvements in drug efficacy and patient compliance. Nucleation ; Carbamazepine ; Solubility ; Precipitation ; Amorphous solid ; Dissolution ; Crystallization ; Materials science ; Phase (matter) ; Polyamorphism ; Chemical engineering ; Phase transition ; Oxcarbazepine ; Chemistry ; Organic chemistry ; Thermodynamics ; Epilepsy Crystallization and Solubility Studies ; Liquid Crystal Research Advancements ; Surfactants and Colloidal Systems
Authors: Ferdy Rahmat Hidayat | Yusreni Warmi | Sitti Amalia | Arifita Yuana Dewi Rachman
Source: ELECTRON Jurnal Ilmiah Teknik Elektro (article, 2025-11-30)
Field: Materials Science — Materials Chemistry

Analisis Hidrofobisitas dan Estimasi Kekuatan Dielektrik Isolator Keramik 150kV dengan Pelapisan RTV-SiR+SiO₂ untuk Peningkatan Keandalan Sistem Transmisi Listrik Permasalahan utama pada jalur transmisi Koto Panjang–Payakumbuh adalah tingginya tingkat polusi dan kelembapan, yang mempercepat degradasi permukaan isolator dan meningkatkan kemungkinan terjadinya flashover. Penelitian ini bertujuan untuk menganalisis karakteristik hidrofobisitas serta mengestimasi kekuatan dielektrik isolator keramik 150 kV sebelum dan sesudah dilakukan pelapisan menggunakan campuran RTV (Room Temperature Vulcanizing) silikon rubber dan nanopartikel SiO₂. Metode penelitian bersifat kuantitatif eksperimental dan mengikuti standar IEC TS 62073-2016. Evaluasi hidrofobisitas dilakukan dengan metode sessile drop, sedangkan pelapisan diterapkan menggunakan teknik spray coating dengan formulasi RTV-683, silika, hardener, thinner, dan xylene. Hasil penelitian menunjukkan peningkatan signifikan pada hidrofobisitas permukaan, ditandai dengan kenaikan sudut kontak dari rata-rata 72° menjadi 113° setelah pelapisan. Isolator yang telah dilapisi juga mengalami penurunan arus bocor hingga 46% dibandingkan kondisi sebelum pelapisan, serta peningkatan kekuatan dielektrik dari 73,58 kV menjadi 163,70 kV. Korelasi empiris menunjukkan hubungan kuat antara peningkatan hidrofobisitas dan perbaikan performa listrik. Kebaruan penelitian ini terletak pada integrasi analisis hidrofobisitas dan estimasi kekuatan dielektrik pada isolator keramik yang beroperasi di lingkungan tropis dengan penggunaan nano-coating RTV–SiO₂, yang masih jarang diteliti pada studi sebelumnya Isolator ; Cervical spine ; Bogie High voltage insulation and dielectric phenomena ; Lightning and Electromagnetic Phenomena ; Thermal Analysis in Power Transmission
Authors: Djamil Benghida | Riad BenGhida | Sabrina BenGhida | Sonia Benghida | Sonia BenGhida
Source:  (article, 2025-12-04)
Field: Materials Science — Materials Chemistry

Nanotechnology for Sustainable Cities: Benefits and Risks of Nano-Enabled Building Materials Nanotechnology is reshaping the built environment by enabling the development of materials that improve structural performance, energy efficiency, durability, and environmental quality. This paper reviews nano-enabled construction materials through a micro–meso–macro lens, linking material mechanisms to building behavior and urban impacts. It highlights both their potential contributions to decarbonization, public health, and urban resilience, and the parallel challenges of energy-intensive production, uncertain toxicological profiles, and regulatory gaps. Finally, it argues for responsible integration based on life-cycle thinking, precautionary risk governance, and updated architectural and engineering education so that nano-enabled innovation supports truly sustainable, equitable cities rather than new forms of hidden risk. Sustainable development ; Sustainable energy ; Applications of nanotechnology ; Societal impact of nanotechnology ; Built environment ; Architecture Nanoparticles: synthesis and applications ; Environmental remediation with nanomaterials ; Nanotechnology research and applications
Authors: Chen Chen | Ximo Wang | Dongxiao Sun‐Waterhouse | Geoffrey I. N. Waterhouse | Zhixiang Xu
Source: Agricultural Products Processing and Storage (article, 2025-11-03)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Surface-enhanced Raman spectroscopy biosensor platforms for pesticide residue detection: state-of-the-art developments and future outlook In the agricultural sector, pesticides are widely used to enhance crop yields and protect plants from pests and diseases. However, pesticide residues pose significant threats to humans, animals, insects and ecosystems. Accordingly, the rapid, sensitive, and accurate detection of pesticide residues is of great significance for protecting human health and the wider environment. Surface-enhanced Raman spectroscopy (SERS) is increasingly being applied for the detection of hazardous substances in foods. Furthermore, biological recognition elements (such as antibodies, aptamers, etc.) are widely applied in food safety assessment due to their high specificity and low cost. Combining bio-affinity elements with SERS technology can create efficient and accurate pesticide residue detection platforms. This review summarizes recent progress in the development of SERS biosensors for the detection of pesticide residues. Strategies for integrating specific recognition elements (especially antibodies and aptamers) with the plasmonic SERS nanosystems are discussed. Then, selected case studies are introduced highlighting the advantages of such SERS biosensors for pesticide detection, before future prospects of this research field are discussed. This review guides the development novel SERS biosensors for pesticides and other target analytes. Biosensor ; Pesticide residue ; Pesticide ; Human health ; Surface-enhanced Raman spectroscopy ; Hazardous waste Gold and Silver Nanoparticles Synthesis and Applications ; Biosensors and Analytical Detection ; Advanced biosensing and bioanalysis techniques