jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Mo Wang | Mengru Liu | Lijie Gao | Jiawei Liu | Xifu Liu | Ling Zhang | Yu Cheng
Source: Journal of Medicinal Chemistry (article, 2025-11-25)
Field: Chemistry — Spectroscopy

Mitochondria-Targeted Fluorescent Probes: Bridging Molecular Innovation and Disease Diagnosis Mitochondria play essential roles in cellular energy metabolism and biological processes, with their dysfunction implicated in various diseases. Mitochondria-targeted fluorescent probes have thus been developed to sensitively detect metabolites and monitor mitochondrial metabolic status in real time, aiding in the diagnosis and treatment of mitochondria-related diseases. To overcome limitations such as poor water solubility and instability of conventional probes, structurally optimized molecular fluorescent probes have been designed. In parallel, nanotechnology has facilitated the development of novel mitochondria-targeted nanofluorescence probes. Moreover, computer simulation and artificial intelligence have significantly accelerated probe design and optimization. This review summarizes recent advances in mitochondria-targeted fluorescence probes, emphasizing their structural design, functional properties, and molecular mechanisms. It also highlights the role of computational approaches in promoting innovative development in this field. Fluorescence ; Mitochondrion ; Disease treatment ; Bridging (networking) ; Cellular metabolism ; Metabolic stability ; Metabolic disease Molecular Sensors and Ion Detection ; Mitochondrial Function and Pathology ; Luminescence and Fluorescent Materials
Authors: Huan Liu | Lunjie Wu | Songyin Zhao | Yan Xu | Yao Nie
Source: Biotechnology Advances (article, 2025-12-26)
Field: Chemistry — Organic Chemistry

Enzyme symphony in bio-inspired multi-enzyme cascades for enhanced biosynthesis Cascade ; Symphony ; Synthetic biology ; Cascade reaction ; Parallels ; Enzyme ; Rational design Cyclopropane Reaction Mechanisms ; Enzyme Catalysis and Immobilization ; Microbial Natural Products and Biosynthesis
Authors: Lukas Hohmann | Robert Antpusat | Norbert Kockmann
Source: Crystals (article, 2025-04-12)
Field: Materials Science — Materials Chemistry

Process Design for Continuous Crystallization of l-Tryptophan in Water–Alcohol Solvent Mixtures The study of solid–liquid equilibria in small molecules such as l-tryptophan (l-Trp), which possesses an α-amino group, an α-carboxylic acid group, and an indole compound, presents significant challenges. This research introduces several findings aimed at enhancing process efficiency and sustainability in downstream processing of l-Trp from fermentative origin via crystallization. Transitioning from batch to continuous processes allows for improved scalability and resource management. Furthermore, solubility measurements combined with thermodynamic data from the literature will provide deeper insights into molecular interactions and allow for systematic and data-driven process design. Lab-scale crystallization experiments in both batch and continuous operation allow for the assessment of the process feasibility and solvent impacts on the process and product. The focus is on process development that emphasizes material savings through strategic solvent selection and co-solvent choices. Crystallization ; Alcohol ; Solvent ; Process (computing) ; Tryptophan ; Chemistry ; Chemical engineering ; Process engineering ; Organic chemistry ; Computer science ; Engineering ; Biochemistry ; Amino acid Crystallization and Solubility Studies ; Analytical Chemistry and Chromatography ; Process Optimization and Integration
Authors: Shuaishuai Zhou | Mingju Li | Shaohua Li | Pengfei Zhang | Meihong Liao | Peng Ding | Jingjie Dai
Source: Polymer Composites (article, 2025-08-08)
Field: Materials Science — Materials Chemistry

Structurally Tailored Boron Nitride Networks With Pore‐Engineered and Interfacial Compatibility for Highly Thermally Conductive Epoxy Composites ABSTRACT The rapid advancement of artificial intelligence technology has driven continuous enhancement in chip power density, making thermal management of high‐power components a critical challenge constraining reliability and energy efficiency improvement. However, the micro‐nano interfacial mismatch in boron nitride (BN)/polymer composites has restricted their broader application in thermal management. In the present work, an epoxy resin composite with adjustable pore structure and designed functionalization of BN nanosheets (FBN) was fabricated by pre‐freezing regulation‐ice templating strategy. Benefiting from the optimization of FBN interface compatibility and the regulation of three‐dimensional (3D) pore structure, the epoxy resin/FBN (EBN) composite exhibits highly through‐plane thermal conductivity of 3.07 W m −1 K −1 with 7 wt% FBN loading, representing a 13‐fold enhancement over pure epoxy, while maintaining robust mechanical properties with a compressive strength of 93 MPa. The radial rapid‐freezing method induced the self‐organization of FBN fillers into well‐aligned interpenetrating networks, substantially maximizing interfacial contact between fillers and enabling optimized directional heat flux transfer. Furthermore, finite element simulations confirm the exceptional thermal transfer capability of EBN composites in practical applications, highlighting their suitability for thermal management in highly integrated electronic devices. This study offers novel design strategies for advanced thermal interface materials in next‐generation devices. Materials science ; Composite material ; Epoxy ; Compatibility (geochemistry) ; Boron nitride ; Electrical conductor ; Boron Thermal properties of materials ; Heat Transfer and Optimization ; Graphene research and applications
Authors: Shuai Wang | Liangchao Chen | Jianfeng Yang | Zhan Dou | Xinyuan Lu | Huaizhu Liu | Z.B. Wang | Qiang Wang | Jiangwei Liu
Source: Corrosion Engineering Science and Technology The International Journal of Corrosion Processes and Corrosion Control (review, 2025-06-03)
Field: Materials Science — Materials Chemistry

Corrosion prediction models for chemical systems based on data and mechanism fusion: a review Corrosion is one of the most critical issues affecting the safe and stable operation of chemical systems. Therefore, accurate prediction of corrosion rates is essential for the safety and stability of chemical systems. Traditional mechanism-based models are challenging to construct as they struggle to account for all influencing factors and often lack sufficient accuracy when applied in chemical plants. While data-driven approaches have been widely adopted in the field of corrosion prediction, they suffer from inherent limitations such as poor generalisability, lack of interpretability and a high dependency on data quality. These limitations underscore the urgent need for developing precise and interpretable corrosion rate prediction models that integrate mechanistic insights, thereby enabling effective maintenance of equipment condition. This article systematically reviews the evolution of corrosion prediction models, from those based on kinetic, thermodynamic and electrochemical mechanisms to data-driven models leveraging multi-source data from chemical systems, and finally to mechanism-data fusion models that offer high accuracy and broad generalisability. The article introduces five fusion mechanisms – embedded, inductive, weighted, cascaded and augmented – that integrate the strengths of both mechanistic and data-driven models to enhance predictive accuracy and interpretability. These fusion mechanisms effectively combine the advantages of mechanistic models and data-driven approaches, leading to improved corrosion rate prediction accuracy and enhanced model generalisation. The article also provides a summary of existing models in the field of corrosion prediction and offers a forward-looking perspective on future research directions for mechanism-data fusion-driven corrosion prediction models. Mechanism (biology) ; Corrosion ; Fusion ; Computer science ; Materials science ; Metallurgy ; Philosophy ; Epistemology Corrosion Behavior and Inhibition ; Concrete Corrosion and Durability ; Hydrogen embrittlement and corrosion behaviors in metals
Authors: Shanshan Duan | Meng Hua | Guanda Yang | Dirk Schubert
Source: Thin Solid Films (article, 2025-02-01)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Nickel-plated melamine sponges for versatile applications in flame resistance, electromagnetic absorption and advanced sensing Melamine ; Nickel ; Absorption (acoustics) ; Materials science ; Chemical engineering ; Sponge ; Metallurgy ; Chemistry ; Composite material ; Engineering Electromagnetic wave absorption materials ; Polydiacetylene-based materials and applications ; Metamaterials and Metasurfaces Applications
Authors: Jose Bolaños‐Cardet | Belén Pepió‐Tárrega | Javier Saiz‐Poseu | Alba López‐Moral | Faiz Ullah | Vı́ctor J. Yuste | Daniel Ruiz‐Molina | Salvio Suárez–García
Source: Angewandte Chemie (article, 2025-11-24)
Field: Chemistry — Organic Chemistry

The Redox Properties of Polyphenols and Their Role in ROS Generation for Biomedical Applications Abstract Polyphenols, particularly catechols, represent a significant class of compounds characterized by their versatile physicochemical and biological properties, sourced from both natural origins and industrial by‐products. This review highlights their critical redox properties, which enable both antioxidant activity and controlled reactive oxygen species (ROS) generation. These dual capacities underpin their diverse biomedical applications, including the development of materials like nanoparticles, hydrogels, bioadhesives, coatings, and membranes. The review explores their utility in areas such as antimicrobial strategies, advanced cancer therapy, and tissue regeneration, demonstrating how their ROS modulation drives therapeutic effects. Despite promising preclinical studies, significant challenges persist in clinical translation, encompassing pharmacokinetics, biosafety, regulatory pathways, and manufacturing consistency. Future perspectives emphasize the crucial need for deeper understanding and precise control of ROS dynamics, advanced delivery systems, rational material design, and the integration of artificial intelligence (AI) to accelerate research and clinical validation. This comprehensive review synthesizes the current state, challenges, and future directions for polyphenol‐based biomedical materials. Reactive oxygen species ; Rational design ; Redox ; Polyphenol ; Dual (grammatical number) ; Antioxidant ; Cancer therapy ; Dual role Free Radicals and Antioxidants ; Advanced Nanomaterials in Catalysis ; Phytochemicals and Antioxidant Activities
Authors: Yanjuan Dong | Chengrong Chen | Amare Worku | Youqi Ke | Hou‐Yong Yu | Fengyuan Zou | Junjie Zhou
Source: ChemSusChem (article, 2025-10-09)
Field: Materials Science — Biomaterials

Hierarchical Silk‐Based Textile Sensor: Recent Advances in Multidimensional Processing and Multiscenario Applications With the growth of artificial intelligence and the Internet of Things (IoT), flexible sensors have been widely used in health monitoring, human-computer interaction, soft robotics, smart homes, and energy harvesting owing to their light weight, sensitivity, and stretchability. Unlike impermeable films and hydrogel materials, silk fibers/textiles have been considered the ideal sensing materials due to their excellent mechanical flexibility, biocompatibility, biodegradability, sustainability, and ease of processing. The current review mainly focuses on the mesoscopic doping research of silk fibroin materials and their applications in the medical field. However, no review systematically summarizes the preparation, processing, and multifunctional applications of silk-based textile sensors. In this review, it provides a comprehensive and timely overview of flexible silk-based textile sensors, including multilevel structural and multidimensional sustainability of silk, multiple processing strategies, and multiscenario applications. The silk hierarchical structure is discussed well with their excellent performance, and then the detailing merits and drawbacks of each spinning technique are discussed. Further, this review provides a summary of the emerging applications and future challenges in flexible silk-based textile sensors. This review aims to provide an insightful viewpoint on the fascinating silk-based textile sensors. Textile ; Biomimetics ; Spinning ; Fibroin ; Soft materials ; Modular design Silk-based biomaterials and applications ; Advanced Sensor and Energy Harvesting Materials ; Conducting polymers and applications
Authors: M.S. Anwar | Iqra Afzal | H. A. ABID | Ihsan Ullah | Usman Ul Haq
Source: Kashf Journal of Multidisciplinary Research (article, 2025-03-10)
Field: Materials Science — Biomaterials

NANOPARTICLES IN DRUG DELIVERY: A CHEMICAL ENGINEERING PERSPECTIVE ON BIOCOMPATIBILITY, TARGETING, AND CONTROLLED RELEASE MECHANISMS Nanoparticles are increasingly being used in drug delivery systems for improving targeting, drug release, and biocompatibility of the drug molecules. This paper discusses the role of nanoparticles in drug delivery, concentrating on their biocompatibility, targeting and controlled release systems. Polymeric (PLGA, chitosan), lipid-based (liposomes, solid lipid nanoparticles), and inorganic (gold and silica) nanoparticles were synthesized and analysed based on physicochemical properties, drug entrapment efficiency, drug release profile, cell viability and distribution. These findings showed that liposomal nanoparticles had the highest encapsulation efficiency (90%) and better biocompatibility while PLGA nanoparticles showed a gradual release of the drug for up to 72 hours. In terms of cell toxicity, it was observed that polymeric and lipid-based nanoparticles had a low toxic effect on the cells, while gold and silica nanoparticles triggered severe toxicity at higher concentrations. The biodistribution of the liposomes also supported the results of the EPR effect analysis indicating that liposomes had the highest uptake in tumor tissue (48%) compared to PLGA (35%) and chitosan (21%). In other pharmacokinetic tests on controlled drug release, it was observed that Polymeric nanoparticles released their drugs gradually by diffusion as well as degradation while Liposomes released the drug quickly because of its amphiphilic nature. Additionally, just for PEGylation and Ligand conjugation the circulation time was enhanced and targeting efficiency were reduced off target accumulation . However, there are still several barriers that have hindered the future clinical application: stability, scalability, and finally approval. In this article, the properties of nanoparticles for drug delivery are discussed, noting the opportunities and challenges that require optimization in the future. The global market for nanomedicine is still in a developmental stage, relying on stimuli-responsive systems and AI-assisted formulation design to overcome current challenges in the near future. Biocompatibility ; Drug delivery ; Nanotechnology ; Nanoparticle ; Perspective (graphical) ; Drug ; Materials science ; Engineering ethics ; Chemistry ; Pharmacology ; Medicine ; Engineering ; Computer science ; Organic chemistry Nanoparticle-Based Drug Delivery
Authors: Aditya Yadav | Eugene Lee | Rui Chen | So-Ryong Chae | Yujie Sun | Jiajie Diao
Source: Materials Today Bio (article, 2025-10-01)
Field: Materials Science — Materials Chemistry

Understanding the role of polyethylene glycol coating in reducing the subcellular toxicity of MXene nanoparticles using a large multimodal model MXenes exhibit remarkable properties such as high electrical conductivity, mechanical strength, and versatile surface chemistry, positioning them as promising candidates for various applications in energy storage, biomedical engineering, and environmental remediation. However, concerns regarding their potential toxicity necessitate a deeper understanding of their interactions with biological systems. This study investigates the subcellular interactions of MXenes, focusing on the mitochondria, endoplasmic reticulum (ER), and lysosomes. Using structured illumination microscopy (SIM), the observations reveal that MXenes exhibit selective toxicity, primarily causing structural damage to the ER, while leaving mitochondria and lysosomes largely unaffected. This organelle-specific toxicity appears to be linked to the negative surface charge of MXenes, which modulates their interactions with cellular components. Notably, surface modification of MXenes with polyethylene glycol (PEG) significantly reduces ER toxicity, thereby improving biocompatibility and offering a promising strategy for safer biomedical applications. Building on these findings, it also introduces a novel methodology that employs a large multimodal model (LMM), a state-of-the-art artificial intelligence (AI) framework, for the automated analysis and interpretation of super-resolution microscopy images. MXenes ; Polyethylene glycol ; Biocompatibility ; Endoplasmic reticulum ; Surface modification ; Surface charge MXene and MAX Phase Materials ; Nanomaterials for catalytic reactions ; Graphene and Nanomaterials Applications
Authors: Leonard Whye Kit Lim
Source: Journal of Dermatologic Science and Cosmetic Technology (article, 2025-10-31)
Field: Materials Science — Biomaterials

Spider silk applications: Dermatologic theranostics, cosmetics, aerospace, textile and electronics Spider silk is an exceptional biomaterial renowned for its strength, elasticity, biodegradability, and biocompatibility. Advances in recombinant DNA have enabled scalable production, broadening its applications. In biomedicine, it supports wound healing, nerve regeneration, sutures, and drug delivery due to its low immunogenicity. In cosmetics, its amino acid-rich profile enhances skin hydration and repair. In aerospace and electronics, its strength, thermal stability, and optical clarity enable use in lightweight composites and biodegradable sensors. However, challenges such as cost-effective production, scalability, and regulatory approval remain barriers to widespread adoption. Future progress will rely on integrating artificial intelligence, synthetic biology, and sustainable technologies to optimize manufacturing and unlock new applications. This review highlights spider silk’s growing potential across industries and underscores the importance of overcoming current limitations to position it as a key eco-smart material for the future. Textile ; Aerospace ; Spider ; CLARITY ; Spider silk ; Electronics Silk-based biomaterials and applications ; Electrospun Nanofibers in Biomedical Applications ; Wound Healing and Treatments
Authors: S. Murali | Jörg Thomas | John Abraham | Vignesh Kanna | Sivaramakrishnan Ramachandiran | Suruthi SS
Source: OpenNano (article, 2025-11-20)
Field: Materials Science — Materials Chemistry

Nanodiagnostics and nanotoxicology: A systematic review and meta-analysis on nanoparticle applications and safety in metabolic organs Nanotechnology is reshaping the biomedical landscape by offering unprecedented capabilities in disease diagnostics, targeted therapy, and biosensing. Nanoparticles (NPs), owing to their unique physicochemical properties, enable ultra-sensitive biomarker detection, real-time monitoring, and minimally invasive assays across oncology, infectious diseases, and neurology. However, their biological interactions also raise significant concerns regarding organ-specific toxicity, particularly in metabolic systems. This systematic review and meta-analysis aim to integrate current evidence on nanoparticle-based diagnostic applications with emerging insights into their toxicological impacts on key metabolic organs — liver, kidney, pancreas, spleen, and adipose tissue. It further examines mechanistic pathways, dose-dependent effects, and translational challenges to bridge the gap between innovation and biosafety. A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, and Google Scholar from January 2015 to October 2025 following PRISMA 2020 guidelines. Eligible studies reported quantitative diagnostic performance metrics (e.g., limit of detection, sensitivity, multiplexing capacity) or biological outcomes (e.g., oxidative stress, apoptosis, fibrosis, endocrine disruption) related to NP exposure. Meta-analytic synthesis was performed on 42 studies reporting comparable quantitative toxicity data. Diagnostic applications of metallic, polymeric, photonic, and hybrid nanoparticles demonstrated up to a 1000-fold improvement in sensitivity over conventional assays, with mean detection limits reaching the femtomolar range. However, pooled toxicity analysis revealed significant organ-specific risks: hepatic ROS generation (standardized mean difference [SMD] = 1.42, 95% CI: 1.10–1.75), renal tubular apoptosis (SMD = 1.27, 95% CI: 0.94–1.61), and β-cell impairment (SMD = 1.18, 95% CI: 0.88–1.49). Translational challenges remain due to poor clearance kinetics, chronic inflammation, and incomplete regulatory frameworks. Nanoparticles hold transformative potential in precision diagnostics, but their clinical adoption demands a nuanced understanding of toxicological trade-offs. Future research must focus on biodegradable and renal-clearable materials, mechanistically guided design strategies, standardized toxicological protocols, and AI-driven predictive models. This review provides a dual-perspective framework that integrates diagnostic breakthroughs with biosafety imperatives, guiding the next phase of nanomedicine toward safe and effective clinical translation. Biomarker ; Biomarker discovery ; Systematic review ; Metabolomics ; Toxicity ; Disease ; Risk assessment Nanoparticles: synthesis and applications ; Nanoparticle-Based Drug Delivery ; Advanced Nanomaterials in Catalysis
Authors: Ruifeng Zhang | Huiling Zhao | Na Li | Yiyuan Chen | Yuwei Hu | Qiuting Zhang | Xi Chen | Qifeng Ruan | Yi Long | Yujie Ke
Source: Advanced Functional Materials (article, 2025-11-02)
Field: Materials Science — Materials Chemistry

Mechanochromic Materials: From Principles, Multi‐Mode Integration, to Emerging Applications Abstract Mechanochromic materials, which dynamically alter their optical properties in response to mechanical stimuli, represent a versatile platform of smart materials. This review comprehensively overviews recent advances in mechanochromic systems, focusing on two primary mechanisms: structural color modulation and emission color changes. Structural color modulation, often based on reflection, represents the more common approach, while emission color changes, though highly sensitive, constitute a significant complementary strategy. Materials are classified by their different responses to applied strains, including in‐plane (stretch/compression), out‐of‐plane (grinding/shear), and multiaxial (bending) strains. This review also analyzes multi‐stimuli integration with thermochromic, chemochromic, and photochromic functionalities for enhanced versatility. Applications are analyzed, including sensing, displays, anti‐counterfeiting, smart windows, and bioinspired artificial skins, with significant highlights in dual‐signal photonic‐ionic skins and mechanoelectrical sensors. Finally, the opinions are shared on challenges in scalability, environmental stability, spectral tunability, and real‐world implementation, as well as the future directions emphasizing biohybrid systems, artificial intelligence‐driven design, and scalable manufacturing. This review systematically summarizes the progress in mechanochromic materials, which will promote future fundamental research, functionalization, as well as the advancement toward practical applications. Smart material ; Scalability ; Structural coloration ; Biomimetics ; Photochromism ; Modulation (music) Luminescence and Fluorescent Materials ; Advanced Sensor and Energy Harvesting Materials ; Pigment Synthesis and Properties