jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Guoqing Yang | Nan Ding | Chuanning Jiang | Peizhi Yang | Qingqing Gao | Yichen He | Lu Han
Source: Materials (article, 2025-04-17)
Field: Materials Science — Materials Chemistry

Investigation of the Insulation Characteristics of TPU/EP Composites Under Cold Thermal Shock To improve the issue of the decreased toughness and electrical performance of epoxy resin (EP) in thermal shock environments, we prepared thermoplastic polyurethane elastomer (TPU)-filled modified EP composites. We also studied the mechanical and electrical performance of these composites, which had different TPU filling contents, under thermal shock conditions. The results indicated that after 240 h of thermal cycling between -15 °C and 100 °C, the TPU/epoxy composites, when compared to unmodified EP, exhibited a 10.1% enhancement in their elastic modulus, a 15.3% increase in their elongation at break, a 22.3% improvement in their tensile strength, and a 47.8% increase in their impact strength. Moreover, their volume resistivity increased by 10.5% and their AC breakdown strength improved by 52.1%. In contrast, their dielectric constant and dielectric loss experienced reductions of 40.2% and 7.5%, respectively. This study demonstrates that introducing flexible TPU molecular chains into the resin significantly enhances the toughness of EP structures. Additionally, the new cross-linked structures formed within the TPU/EP composites improve their insulation performance under thermal shock conditions. Composite material ; Materials science ; Thermoplastic polyurethane ; Epoxy ; Ultimate tensile strength ; Thermal shock ; Toughness ; Dielectric ; Dielectric strength ; Elastomer ; Thermal conductivity High voltage insulation and dielectric phenomena ; Dielectric materials and actuators ; Advanced Sensor and Energy Harvesting Materials
Authors: Felipe de Lima Franzen | Mari Silvia Rodrigues de Oliveira | Helena María André Bolini
Source: Revista Fitos (review, 2025-02-01)
Field: Chemistry — Analytical Chemistry

A review of six medicinal and aromatic plants and their health benefits Brazil has a large biodiversity of plants with nutritional and biological properties that are important for humannutrition. The objective of this study is to review the use of plants in nutrition and the presence of bioactivecompounds that bring health benefits, referencing research with six different native and exotic plant species(“açaí”, “cinnamon”, “guarana”, “hibiscus”, “jambu” and “yerba mate”). Numerous studies on theaforementioned plants have been carried out to evaluate and confirm their effects and benefits. Clinical andmetabolic studies have shown that the consumption of these plants, especially their extracts, can prevent ortreat several diseases such as Alzheimer's, cancer, obesity, diabetes, cardiovascular disease,atherosclerosis, hepatic and cardiovascular fibrosis. The use of extracts from these plants in foods improvessome quality characteristics such as oxidative stability, nutritional value, hygienic-sanitary and sensoryproperties, in addition to the foods becoming functional with antioxidant properties. This review indicates thatthese plants have the potential to be used as ingredients in formulations of various foods and should beconsidered important for future studies with the investigation of their effects on these foods. Aromatic plants ; Traditional medicine ; Business ; Psychology ; Medicine ; Biology ; Botany Heavy Metals in Plants ; Ethnobotanical and Medicinal Plants Studies ; Complementary and Alternative Medicine Studies
Authors: Mr. Salve Rohan | Maria Gayatri | Ms. Varpe Amruta | Ms. Devkate Dipali | Ms. Palange Sanika | Rahualkumar D. R. | Ms. Kardile Pratiksha
Source: International Journal of Advanced Research in Science Communication and Technology (article, 2025-12-01)
Field: Materials Science — Biomaterials

Review on Caralluma Fimbriata Syrup Caralluma fimbriata, an edible succulent of the Apocynaceae family, is traditionally recognized in Indian medicine for its applications as an appetite suppressant and an enhancer of endurance. Historically, tribal communities have utilized it as a famine food. Its chemical composition includes various phytochemicals, notably pregnane glycosides, flavonoids, saponins, and phenolic compounds. These constituents confer a range of pharmacological activities, encompassing anti-obesity, anti-diabetic, antioxidant, anti-inflammatory, and hepatoprotective effects. In contemporary pharmaceutics, Caralluma fimbriata has emerged as a significant functional food and nutraceutical component. Syrup formulations, among other dosage forms, present several benefits, including ease of administration, dose flexibility, and improved taste masking for potentially bitter extracts. The inclusion of honey as a natural sweetening agent in Caralluma fimbriata syrup not only improves palatability but also augments its therapeutic potential, attributed to honey's inherent antimicrobial, antioxidant, and immunomodulatory properties. This review aims to comprehensively examine the morphological and microscopic characteristics, medicinal applications, pharmacological activities, and future prospects of Caralluma fimbriata, specifically focusing on its development as a syrup-based herbal formulation Nutraceutical ; Palatability ; Sweetness ; Medicinal plants ; Bitter taste ; Health benefits Phytochemistry and Bioactive Compounds ; Phytochemistry and Biological Activities ; Phytochemistry and Bioactivity Studies
Authors: Junan Lin | Jiří Hostaš | Anguang Hu | Hang Hu | Hsu Kiang Ooi | Mohammad Sajjad Ghaemi
Source: Research Square (preprint, 2025-09-25)
Field: Materials Science — Materials Chemistry

BiRLNN: Bidirectional Reinforcement-Learning Neural Network for Constrained Molecular Design Reinforcement learning ; Process (computing) ; Constraint (computer-aided design) ; Space (punctuation) ; Artificial neural network ; Chemical space ; Function (biology) Machine Learning in Materials Science ; Computational Drug Discovery Methods
Authors: G. Sowmya
Source: INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT (article, 2025-07-04)
Field: Materials Science — Materials Chemistry

Synthesis and Characterization of Samarium-Doped Nickel-Cobalt Ferrite Nanoparticles for Advanced Magnetic Applications Nanoparticles of samarium-doped nickel-cobalt ferrites with the formula Ni₀.₇Co₀.₃Fe₂₋ₓSmₓO₄ (x = 0.00 and 0.015) were successfully synthesized using the citrate gel auto-combustion method. X-ray diffraction analysis confirmed the formation of a pure cubic spinel phase, with a slight reduction in lattice constant from 8.3502 Å to 8.3319 Å as samarium content increased, indicating the substitution of Sm³⁺ ions into the spinel lattice. The crystallite size decreased from approximately 35.2 nm for the undoped sample to 23.5 nm for the doped sample, reflecting the influence of samarium on grain growth. Field Emission Scanning Electron Microscopy revealed spherical particles with some agglomeration, typical of chemically synthesized ferrite nanoparticles. Magnetic studies showed a modest decrease in saturation magnetization from 30.6 emu/g to 29.6 emu/g and remanent magnetization from 16.0 emu/g to 15.2 emu/g upon doping, along with a slight decline in the coercivity ratio, indicating altered magnetic interactions due to Sm³⁺ incorporation. These modifications highlight the potential of samarium-doped Ni-Co ferrite nanoparticles for use in magnetic storage, microwave devices, sensors, and biomedical applications such as drug delivery and magnetic hyperthermia. Keywords: Samarium-doped ferrites, Ni-Co ferrite nanoparticles, Citrate gel auto-combustion, Nanoparticle morphology. Samarium ; Materials science ; Nickel ; Cobalt ; Doping ; Nanoparticle ; Characterization (materials science) ; Ferrite (magnet) ; Cobalt ferrite ; Magnetic nanoparticles ; Metallurgy ; Chemical engineering ; Nanotechnology ; Inorganic chemistry ; Chemistry ; Optoelectronics ; Composite material ; Engineering Magnetic Properties and Synthesis of Ferrites
Authors: Nanor Gragousian | Shirzad Amiri | Hossein Ali Khonakdar
Source: Research Square (preprint, 2025-12-30)
Field: Materials Science — Materials Chemistry

Structural characterization of copper and manganese oxide nanoparticles-doped calcium silicate (CaSiO 3 ) for synthesized via sol-gel method Biocompatibility ; Simulated body fluid ; Nanoparticle ; Copper ; Scanning electron microscope ; Fourier transform infrared spectroscopy ; Energy-dispersive X-ray spectroscopy ; Manganese Nanoparticles: synthesis and applications ; Magnesium Oxide Properties and Applications ; Copper-based nanomaterials and applications
Authors: Olga B. Bekker | Olesya O. Galanova | Aleksey A. Vatlin | Svetlana G. Frolova | Egor Shitikov | Dmitry Bespiatykh | Ksenia M. Klimina | Vladimir A. Veselovsky | Rustem Ilyasov | Svetlana V. Smirnova | Diana A. Reznikova | N. I. Kochetkov | Dmitry A. Maslov | В. Н. Даниленко
Source: International Journal of Molecular Sciences (article, 2025-04-14)
Field: Chemistry — Organic Chemistry

A Quinoxaline 1,4-Dioxide Activates DNA Repair Systems in Mycobacterium smegmatis: A Transcriptomic Study In 2022, the World Health Organization reported that tuberculosis (TB) was the second leading cause of death globally from a single infectious agent following COVID-19. The development of new antitubercular agents with novel mechanisms of action for use in complex TB therapy is considered a key approach to combating TB. In this study, we examined the gene expression profile of <i>M. smegmatis</i> when exposed to a promising antituberculosis agent, quinoxaline 1,4-dioxide (QdNO) 7-chloro-2-(ethoxycarbonyl)-3-methyl-6-(piperazin-1-yl)quinoxaline-1,4-dioxide-1 (LCTA-3368). We investigated how the bacterial response changed with different minimum inhibitory concentrations (MIC) (1/4 × MIC, 1/2 × MIC, and 1 × MIC) and durations (30 min and 90 min) of treatment with the drug. Our analysis revealed significant upregulation in genes involved in DNA repair and replication processes, as well as changes in the expression of 95 genes encoding proteins with oxidoreductase activity. We additionally showed that the concentration of reactive oxygen species increases in a dose-dependent manner upon exposure of <i>M. smegmatis</i> to LCTA-3368. These findings support the proposed mechanism of antibacterial action of QdNOs, which is associated with the formation of free radicals leading to DNA damage. Mycobacterium smegmatis ; Transcriptome ; DNA repair ; DNA damage ; Mycobacterium tuberculosis ; DNA ; Microbiology ; Chemistry ; Gene ; Biology ; Gene expression ; Tuberculosis ; Biochemistry ; Medicine Synthesis and Biological Evaluation ; Bioactive Compounds and Antitumor Agents ; Mycobacterium research and diagnosis
Authors: Md. Mustakim Ahmmad | M.S. Rabbi
Source: Journal of Engineering Advancements (article, 2025-12-27)
Field: Materials Science — Polymers and Plastics

From Waste to Innovation: A Review on Textile Waste-Based Composite Materials The continuous acceleration of the textile industry, fueled by fast fashion and global demand, has led to the generation of millions of tons of textile waste throughout the world. Eventually, these textile wastes are dumped into the landfill or incinerated, which causes air, water, and soil pollution. Due to this issue, serious consequences for public health and the environment are arising. Considering this global environmental crisis, this review dives into the possibility of using textile waste in order to produce composite materials. This paper highlights various types and sources of textile wastes, followed by a detailed overview of several manufacturing methods such as compression molding, vacuum bag molding, and injection molding. The developed materials were further characterized for their mechanical, thermal, and acoustic behaviors. Results from different studies report that waste-based composites can exhibit high strength, good ductility, thermal insulation, and sound absorption properties. The alternative materials presented showcase tremendous potential across multiple industries, including automotive, construction, furniture, and electronics. Producing quality alternative materials from textile waste is an approach that supports the principles of the circular economy and promotes sustainable development. The review accentuates the significance of continuous research and innovation in the process of transforming textile waste into useful resources through eco-friendly and cost-effective solutions. Textile ; Raw material ; Waste material ; Municipal solid waste ; Sustainability ; Process (computing) ; Textile industry Textile materials and evaluations ; Dyeing and Modifying Textile Fibers ; Natural Fiber Reinforced Composites
Authors: Zitong Xiong | Jiangtao Pu
Source: Cancer Management and Research (article, 2025-12-01)
Field: Chemistry — Organic Chemistry

Matrine and Its Derivatives: Multi-Pathway Regulation in Cancer Therapy Matrine and its derivatives, as multi-target natural alkaloids, exhibit synergistic antitumor effects through the regulation of core oncogenic pathways including <i>Wnt/β-catenin, MAPK/ERK</i>, and <i>PI3K/AKT/mTOR</i>. These compounds inhibit tumor proliferation by suppressing <i>epithelial-mesenchymal transition (EMT)</i>, inducing programmed cell death (apoptosis, autophagy, and pyroptosis), and remodeling the tumor immune microenvironment. Preclinical studies demonstrate that third-generation derivatives (e.g.MT-26, YF-18) enhance therapeutic efficacy by targeting <i>DNMT1/HDAC6</i> dual inhibition and activating the NLRP3/caspase-1 pyroptosis pathway, achieving tumor suppression rates of 60-78% in pancreatic and liver cancer <i>patient-derived xenograft (PDX)</i> models while overcoming chemotherapy resistance. However, preclinical-to-clinical translation faces challenges such as low bioavailability, off-target toxicity (e.g.hepatotoxicity via <i>JNK/c-Jun</i> activation), and tumor heterogeneity-driven resistance mechanisms (eg <i>SLC7A11-</i>mediated ferroptosis evasion); notably, no Phase I/II clinical trials for matrine or its derivatives in cancer therapy have been registered to date. Future research should prioritize the development of intelligent delivery systems (DNA origami nanorobots, magnetically guided micro/nano-swimmers), multi-omics-driven precision strategies (spatial metabolomics, single-cell epi-drugomics), and synthetic biology platforms (<i>PROTAC</i> bifunctional molecules, AI-assisted crystal screening). Integrating organ-on-chip technologies and real-world data analytics will accelerate the transformation of matrine-based compounds into next-generation intelligent anticancer agents, offering innovative solutions for comprehensive cancer management. Matrine ; Cancer therapy ; Cancer ; Pancreatic cancer ; Cancer cell ; Clinical trial ; Immunogenic cell death ; Combination therapy ; Immune system Ferrocene Chemistry and Applications ; Bioactive natural compounds ; Ferroptosis and cancer prognosis
Authors: Thaloengsak Keereemasthong | Thidarat Kanthiya | Kittiphat Kochchapong | Sattaya Chaiwithee | Pornchai Rachtanapun | Kittisak Jantanasakulwong | Jonghwan Suhr | Choncharoen Sawangrat | Pitiwat Wattanachai
Source: Buildings (article, 2025-08-25)
Field: Materials Science — Polymers and Plastics

Enhanced Mechanical Performance of GFRP Rebars Using Plasma-Treated Natural Fiber Powder Fillers In this study, glass fiber-reinforced polymer (GFRP) rebars were fabricated using epoxy resin matrix filled with 5 wt.% of hemp and bamboo powder fillers, both untreated and dielectric barrier discharge (DBD) plasma treated. The tensile, flexural, transverse shear, and pull-out bond strengths were evaluated to investigate the effects of filler type and surface modification. The results show that the incorporation of untreated fillers decreased tensile strength from 706.4 MPa for hemp to 682.3 MPa for bamboo. The plasma-treated hemp formulation demonstrated a higher recovery (762.1 MPa), approaching the control value (804.2 MPa). Transverse shear strength increased from 117.0 MPa (untreated hemp) to 128.3 MPa (plasma-treated hemp). The bond strength with concrete remained unaffected across all groups. Scanning electron microscopy (SEM) revealed improved filler dispersion, reduced voids, and enhanced resin wetting in the plasma-treated specimens. Fourier-transform infrared spectroscopy (FTIR) confirmed the introduction of polar functional groups such as hydroxyl and carbonyl groups onto the fiber surfaces following plasma exposure. These modifications contributed to improved interfacial adhesion and mechanical integrity. Overall, the DBD plasma treatment effectively enhanced the performance and interfacial characteristics of natural fiber-filled GFRP rebars, supporting their potential as sustainable reinforcements in structural applications. Materials science ; Fibre-reinforced plastic ; Composite material ; Fiber ; Plasma ; Natural fiber Natural Fiber Reinforced Composites ; Electromagnetic wave absorption materials ; Advanced Cellulose Research Studies
Authors: Ozlem Coskun
Source: Northern Clinics of Istanbul (article, 2025-01-01)
Field: Chemistry — Spectroscopy

Different chromatographic techniques and recent advancements for biomedical and pharmaceutical applications Chromatography remains a cornerstone analytical technique in pharmaceutical and biomedical sciences, with recent innovations significantly expanding its capabilities. Advances such as fast chromatography, two-dimensional liquid chromatography (2D-LC), supercritical fluid chromatography (SFC), and hyphenated techniques, including liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS), have broadened the scope of its applications. These developments enhance resolution, sensitivity, and efficiency, enabling more robust analysis of complex biological and pharmaceutical samples. These methods address complex analytical challenges, improving precision, speed, and efficiency in separating and analyzing biomolecules. Emerging technologies, including miniaturized liquid chromatography, shear flow chromatography, column arrays, and microfluidic chip-based systems, present exciting opportunities for the future. These developments enhance the capability of chromatography to analyze trace compounds, optimize drug formulations, and ensure the quality control of pharmaceuticals. Chromatography is also increasingly integrated with cutting-edge techniques like metabolomics and proteomics, furthering its impact on biomarker discovery and personalized medicine. This paper reviews recent advancements in chromatographic methods and their practical applications in the pharmaceutical and biomedical fields. It highlights the critical role of chromatography in drug discovery, purification of therapeutic compounds, and metabolite profiling. Supercritical fluid chromatography ; Biological fluids ; Pharmaceutical drug ; Microfluidics ; Mass spectrometry ; Chromatographic separation ; Therapeutic drug monitoring Analytical Chemistry and Chromatography ; Metabolomics and Mass Spectrometry Studies ; Chromatography in Natural Products
Authors: Yang Xu
Source:  (article, 2025-05-16)
Field: Materials Science — Materials Chemistry

Advances and Prospects of Artificial Intelligence in Materials Science: A Bibliometric Analysis Based on Web of Science Core Database (2005-2024) This study aims to examine the current state and research hotspots of artificial intelligence (AI) applications in materials science over the past two decades (2005–2024), from a bibliometric perspective. Publication volume, citation frequency, H-index, keyword co-occurrence, and other bibliometric indicators were analyzed using data retrieved from the Web of Science Core Collection. The results reveal exponential growth in publications, particularly after 2017, reflecting the increasing maturity and adoption of AI technologies in this field. China leads in publication output, while the U.S. demonstrates higher citation impact per article, indicating complementary strengths in productivity and influence. Institutions such as the Chinese Academy of Sciences and the U.S. Department of Energy emerge as major contributors. Thematic analysis identifies four core research directions: computational design, microstructural analysis, materials modeling, and AI methodologies. Recent trends show a shift toward novel materials discovery, advanced AI techniques, and intelligent systems. This study offers data-driven insights into the evolution of AI-driven materials research and informs future research and international collaboration strategies. Bibliometrics ; Web of science ; Big data ; Citation analysis ; Citation ; China ; Web intelligence ; Thematic map Machine Learning in Materials Science
Authors: Qin Gu | Xiaofei Pan | Hui Ding | Yuan He | Kan Liu
Source: Turkish Journal of Biochemistry (article, 2025-03-19)
Field: Chemistry — Analytical Chemistry

Integrating network pharmacology, in silico molecular docking and experimental validation to explain the anticancer, apoptotic, and anti-metastatic effects of cosmosiin natural product against human lung carcinoma Abstract Objectives This research aimed to examine the anticancer properties of cosmosiin, a natural flavonoid, on human lung carcinoma cells by in silico molecular docking, network pharmacology, and in vitro experiments. Methods The targets of cosmosiin and targets related to lung cancer were retrieved from various databases. The common targets between cosmosiin and lung cancer were identified by venny online server followed by construction of the protein-protein interaction (PPI) network. Further, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment were performed to identify main genes involved along with the signalling pathways affected. The hub genes were used for in silico molecular docking to identify molecular interaction between these targets and cosmosiin. In vitro experiments which consisted of MTT cell viability, clonogenic, cell apoptosis and cell migration assays validated the network pharmacology results. Results Network pharmacology identified 63 common targets between cosmosiin and lung cancer and out of these 63, eight protein targets were found to be most important based on their involvement in numerous signalling pathways in lung cancer. Two (NFKB1 and PIK3R1) out of eight targets showed highest degree values and were subjected to in silico molecular docking which showed cosmosiin showing strong binding the active sites of these two target proteins with PIK3R1 showing higher binding energy value (−9.7 kcal/ml) than NFKB1 (−7.5 kcal/mol). GO and KEGG enrichment analysis revealed key gene functions, molecular functions, cellular components as well as key signalling pathways involved in the treatment of lung cancer by cosmosiin. MTT and apoptotic assays indicated that cosmosiin induced concentration-dependent cytotoxic and apoptotic induction effects in A-549 human lung cancer cells respectively. Cell migration assay exhibited that cosmosiin treatment at varying doses led to a concentration-dependent suppression of cell migration hinting towards the anti-metastatic potency of cosmosiin against lung carcinoma. Conclusions In conclusion, the present study provides strong theoretical and experimental evidence of the anticancer, apoptotic and anti-metastatic potential of cosmosiin natural product against lung carcinoma along with the detailed mechanism of action involving various biological targets, cellular components and signalling pathways. In silico ; Natural product ; Docking (animal) ; Human lung ; Pharmacology ; Apoptosis ; Computational biology ; Cancer research ; Lung ; Medicine ; Biology ; Internal medicine ; Biochemistry ; Gene Chromatography in Natural Products ; Microbial Natural Products and Biosynthesis ; Toxin Mechanisms and Immunotoxins