jablonkagroup/rise_ai_scientists huggingface dataset:
Authors: Ziqian Wang | Huide Wang | Chen Wang | Yushuo Bao | Weiying Zheng | Xiaoliang Weng | Yihan Zhu | Yi Liu | Yule Zhang | Xilin Tian | Shuo Sun | Rui Cao | Zhe Shi | Xing Chen | Meng Qiu | Hao Wang | Jun Liu | Shuqing Chen | Y. J. Zeng | Wugang Liao | Zhangcheng Huang | Hai-Ou Li | Lingfeng Gao | Jianqing Li | Dianyuan Fan | Han Zhang
Source: Nanophotonics (article, 2025-02-01)
Field: Materials Science — Materials Chemistry

Artificial intelligence driven Mid‐IR photoimaging device based on van der Waals heterojunctions of black phosphorus Mid-infrared (Mid-IR) photodetection and imaging are pivotal across diverse applications, including remote sensing, communication, and spectral analysis. Among these, single-pixel imaging technology is distinguished by its exceptional sensitivity, high resolution attainable through the sampling system, and economic efficiency. The quality of single-pixel imaging primarily depends on the performance of the photodetector and the sampling system. Photodetectors based on black phosphorus (BP) exhibit low dark current, high specific detectivity (<i>D</i> <sup>*</sup>), and room-temperature operability. Artificial intelligence (AI)-assisted sampling systems feature efficient and intelligent data reconstruction capabilities. In this work, we demonstrate an AI-driven black phosphorus (BP)/molybdenum disulfide (MoS<sub>2</sub>)/hexagonal boron nitride (hBN) heterojunction for Mid-IR photodetection and imaging. By optimizing the thickness of the heterojunction, the quality of the interface, and the AI algorithm, we achieved high-performance Mid-IR photodetection and imaging. Specifically, the photodetector has a responsivity of 0.25 A/W at a wavelength of 3,390 nm, an extremely high <i>D</i> <sup>*</sup> of 3.7 × 10<sup>9</sup> Jones, a response speed as low as 7 ms, and after AI optimization, the image contrast ratio has been improved from 0.227 to 0.890. At the same time, the sampling rate requirement can be reduced to 25 %. Our research indicates that the efficient combination of BP heterojunction photodetectors and AI technology is expected to accelerate the development of Mid-IR photodetectors and imaging systems. Photodetection ; Photodetector ; Heterojunction ; Optoelectronics ; Materials science ; Responsivity ; Night vision ; Microbolometer ; Optics ; Bolometer ; Physics ; Detector 2D Materials and Applications ; Photonic and Optical Devices ; Advanced Fiber Laser Technologies
Authors: David S. A. Haneen | Abdelaal A. Abdalha | Musaab M. Alkhatib | Mahmoud Kamal | Ahmed S. A. Youssef | Wael S. I. Abou‐Elmagd | Sandy S. Samy
Source: Scientific Reports (article, 2025-07-03)
Field: Chemistry — Organic Chemistry

Synthesis, comprehensive in silico studies, and cytotoxicity evaluation of novel quinazolinone derivatives as potential anticancer agents Quinazolinone derivatives exhibit significant synthetic and biological properties, making them valuable candidates for anticancer drug development. In this study, we synthesized novel quinazolinone derivatives via reactions of the previously unreported 4H-benzoxazin-4-one derivative (2) with various nitrogen nucleophiles, such as hydrazine hydrate and ammonium acetate, which yielded hydrazide and quinazolinone derivatives (3-6). Further modifications were achieved through reactions with carbon electrophiles and carbonyl compounds (e.g., phthalic anhydride, phenyl isothiocyanate, potassium cyanate, and pyrazole carbaldehyde), resulting in an expanded library of novel quinazolinone derivatives (7-15). The structures of all synthesized compounds were confirmed by spectroscopic and microanalytical techniques. In vitro cytotoxicity evaluations (mean IC<sub>50</sub> ± SE, n = 3) revealed promising anticancer activity, with compounds 3 and 5 demonstrating the highest efficacy. To gain deeper mechanistic insights, molecular docking and molecular dynamics simulations were performed against key cancer-related targets, including Topoisomerase II, VEGFR2, c-Met, EGFR, and Estrogen Receptor Alpha. The combined experimental and computational findings suggest that these quinazolinone derivatives hold significant potential as novel anticancer agents, justifying further biological investigations and structural optimizations. Quinazolinone ; Chemistry ; Cytotoxicity ; Combinatorial chemistry ; Pyrazole ; Hydrazide ; Stereochemistry ; In vitro ; Organic chemistry ; Biochemistry Quinazolinone synthesis and applications ; Synthesis and Biological Evaluation ; Synthesis and biological activity
Authors: Cheng Xu | Yan Zhang | Gaolin Liang | Kanyi Pu
Source: Nature Materials (review, 2025-09-16)
Field: Materials Science — Materials Chemistry

Molecular afterglow imaging for biomedical applications Afterglow ; Optical imaging ; Luminescence ; Molecular imaging ; Preclinical imaging ; Autofluorescence ; Microscopy Luminescence and Fluorescent Materials ; Nanoplatforms for cancer theranostics ; Photoreceptor and optogenetics research
Authors: Riddhi Vichare | Jelena Janjić
Source: Theranostics (review, 2025-02-10)
Field: Materials Science — Polymers and Plastics

Perfluorocarbon nanoemulsions in drug delivery: design, development, and manufacturing Perfluorocarbons (PFCs) are formulated into kinetically stable nanoemulsions (NEs) having a droplet diameter less than 500 nm for biomedical applications. PFC NEs are developed for various applications, such as <sup>19</sup>F magnetic resonance imaging tracers, ultrasound contrast agents, and oxygen carriers. They are an attractive platform for theranostic development, as PFC NEs can be designed to deliver a multitude of therapeutics, from small molecules to biologics. Although many reviews have been published on designing PFC NEs as imaging agents or oxygen carriers, there is no comprehensive review of the formulation strategies and manufacturing of PFC NEs as drug delivery platform. From a "formulator's perspective," the presented review addresses this gap as it describes the selection of formulation components such as the PFCs, surfactants, and hydrocarbon oils and provides an overview of manufacturing techniques. In this review, we will also identify potential shortcomings in the published literature on the manufacturing of PFC NEs. We will discuss the need for the implementing Quality by Design (QbD) approach in the manufacturing of PFC NEs to achieve scalability and necessary quality control for supporting both preclinical and clinical applications. Finally, we will review different surface-conjugation strategies for developing targeted PFC NEs. Overall, this article aims to increase understanding of PFC NEs designed for delivering drugs, including both small molecules and biologics. Drug delivery ; Drug ; Nanotechnology ; Chemistry ; Biomedical engineering ; Pharmacology ; Materials science ; Medicine Synthesis and properties of polymers
Authors: Fuat Kara | Nursel Altan Özbek | Onur Özbek
Source: ES Materials & Manufacturing (article, 2025-01-01)
Field: Materials Science — Materials Chemistry

Effect of Cryogenic Treatment on the Machinability of Impax Supreme Steel and Optimization of Machining Parameters This study investigated the effects of process treatment applied to cutting tools during turning of impax supreme alloy on cutting tool tip temperature, vibration, surface roughness and noise.Coated carbide tools coated with TiCN + Al 2 O 3 + TiN by chemical vapour deposition (CVD) method were used as cutting tools.Deep cryogenic treatment was applied to the cutting tools, which were maintained at -196 C for 15 hours.Impax supreme alloy was turned using four different cutting speeds (150, 180, 210, 240 m/min), two different feed rates (0.1 and 0.2 mm/rev) and a constant depth of cut (0.6 mm).As a result of the turning process with cryogenically treated and untreated tools, the nose wear, surface roughness, vibration, noise and cutting tool tip temperature data obtained were evaluated experimentally.Turning experiments with both cryogenically treated and untreated tools showed that the cutting tool wear, cutting tool tip temperature, surface roughness, vibration and noise values decreased after the deep cryogenic treatment applied to the cutting tool.Cryogenic-treated tools exhibited approximately 25%, 25% and 12% lower values for surface roughness, cutting temperature and vibration, respectively.However, no significant difference was observed in noise values.Depending on the cutting conditions, deep cryogenic treatment can reduce cutting tool wear and enhance cutting tool life by up to 150%.It was determined that feed rate was the parameter that had the most dominant effect on surface roughness and vibration, with rates of 69.29% and 89.54%.The results obtained in this study have shown that the cutting tool performance can be greatly improved by cryogenic treatment in the machining of Impax Supreme alloy.In this respect, it will greatly contribute to the literature in machinability studies. Machinability ; Machining ; Materials science ; Metallurgy Metal Alloys Wear and Properties ; Advanced materials and composites ; Advanced machining processes and optimization
Authors: Wei Deng | Tianshu Wang | Lei Li | Xuanyu Xiao | Yuanyuan Xu | Qiujiang Li | Qingsong Zhou | Yong Yin | Hongsheng Yang | Kai Gong | Yue Zhou | Yunbing Wang
Source: Regenerative Biomaterials (review, 2025-01-01)
Field: Materials Science — Materials Chemistry

A review of nanomaterials in osteoarthritis treatment and immune modulation Osteoarthritis (OA) is a highly prevalent degenerative cartilage disease globally. The medical community has recognized it as one of the major public health problems today. Nanomaterials are considered the most promising avenue for OA treatment because they exhibit unique physicochemical properties such as high catalytic activity, bio-enzyme-like reaction kinetics, and modulation of joint immune responses. Besides, nanomaterials can exert higher targeting to improve therapeutic efficacy and reduce side effects. These unique advantages have led to the widespread development of nanomaterials for OA treatment, and they are gradually seeing their most prosperous moment. A timely and comprehensive review of OA pathogenesis-immunomodulation-therapeutic efficacy from a nanomaterials perspective would greatly broaden this research area. This review summarizes the recent advances in nanomaterials for OA treatment. Finally, the main challenges and opportunities for nanomaterials to modulate the immune system for OA treatment are discussed. Immune modulation ; Immune system ; Nanomaterials ; Osteoarthritis ; Modulation (music) ; Computer science ; Nanotechnology ; Medicine ; Immunology ; Materials science ; Physics ; Alternative medicine Advanced Nanomaterials in Catalysis ; Curcumin's Biomedical Applications
Authors: Andrew T. Krasley | S. Chakraborty | Lela Vuković | Abraham G. Beyene
Source: ACS Nano (article, 2025-01-16)
Field: Materials Science — Materials Chemistry

Molecular Determinants of Optical Modulation in ssDNA–Carbon Nanotube Biosensors Most traditional optical biosensors operate through molecular recognition, where ligand binding causes conformational changes that lead to optical perturbations in the emitting motif. Optical sensors developed from single-stranded DNA-functionalized single-walled carbon nanotubes (ssDNA-SWCNTs) have started to make useful contributions to biological research. However, the mechanisms underlying their function have remained poorly understood. In this study, we combine experimental and computational approaches to show that ligand binding alone is not sufficient for optical modulation in this class of synthetic biosensors. Instead, the optical response that occurs after ligand binding is highly dependent on the chemical properties of the ligands, resembling mechanisms seen in activity-based biosensors. Specifically, we show that in ssDNA-SWCNT catecholamine sensors, the optical response correlates positively with the electron density on the aryl motif, even among ligands with similar ligand binding affinities. Importantly, despite the strong correlations with electrochemical properties, we find that catechol oxidation itself is not necessary to drive the sensor optical response. We discuss how these findings could serve as a framework for tuning the performance of existing sensors and guiding the development of new biosensors of this class. Carbon nanotube ; Biosensor ; Nanotechnology ; Modulation (music) ; Materials science ; Physics Carbon Nanotubes in Composites ; Mechanical and Optical Resonators ; bioluminescence and chemiluminescence research
Authors: Larisa Păduraru | Alina Diana Panainte | Cătălina A. Peptu | Mihai Apostu | Mădălina Vieriu | Tudor Bibire | Alexandru Sava | Nela Bibire
Source: Pharmaceuticals (review, 2025-04-13)
Field: Materials Science — Biomaterials

Smart Drug Delivery Systems Based on Cyclodextrins and Chitosan for Cancer Therapy Despite improvements in therapeutic approaches like immunotherapy and gene therapy, cancer still remains a serious threat to world health due to its high incidence and mortality rates. Limitations of conventional therapy include suboptimal targeting, multidrug resistance, and systemic toxicity. A major challenge in current oncology therapies is the development of new delivery methods for antineoplastic drugs that act directly on target. One approach involves the complexation of antitumor drugs with cyclodextrins (CDs) and chitosan (CS) as an attempt to counteract their primary limitations: low water solubility and bioavailability, diminished in vitro and in vivo stability, and high dose-dependent toxicity. All those drawbacks may potentially exclude some therapeutic candidates from clinical trials, thus their integration into smart delivery systems or drug-targeting technologies must be implemented. We intended to overview new drug delivery systems based on chitosan or cyclodextrins with regard to the current diagnosis and cancer management. This narrative review encompasses full-length articles published in English between 2019 and 2025 (including online ahead of print versions) in PubMed-indexed journals, focusing on recent research on the encapsulation of diverse antitumor drugs within those nanosystems that exhibit responsiveness to various stimuli such as pH, redox potential, and folate receptor levels, thereby enhancing the release of bioactive compounds at tumor sites. The majority of the cited references focus on the most notable research, studies of novel applications, and scientific advancements in the field of nanostructures and functional materials employed in oncological therapies over the last six years. Certainly, there are additional stimuli with research potential that can facilitate the drug's release upon activation, such as reactive oxygen species (ROS), various enzymes, ATP level, or hypoxia; however, our review exclusively addresses the aforementioned stimuli presented in a comprehensive manner. Medicine ; Drug delivery ; Narrative review ; Clinical trial ; Cancer therapy ; Pharmacology ; Drug ; Cancer ; Nanotechnology ; Intensive care medicine ; Internal medicine Nanoparticle-Based Drug Delivery ; Nanoplatforms for cancer theranostics ; Advanced biosensing and bioanalysis techniques
Authors: Ludovic Berthier | Giulio Biroli | Lisa Manning | Francesco Zamponi
Source: Nature Reviews Physics (review, 2025-05-19)
Field: Materials Science — Materials Chemistry

Yielding and plasticity in amorphous solids Plasticity ; Materials science ; Amorphous solid ; Chemistry ; Composite material ; Crystallography Material Dynamics and Properties ; Metallic Glasses and Amorphous Alloys ; Glass properties and applications
Authors: Avirup Guha | Seyed Amirhossein Sadeghi | Harikrishnan Hyma Kunhiraman | Fei Fang | Qianyi Wang | Arshia Rafieioskouei | Shaun Grumelot | Hassan Gharibi | Amir Ata Saei | Maryam Sayadi | Neal L. Weintraub | Sachi Horibata | Phillip C. Yang | Borzoo Bonakdarpour | Mohammad M. Ghassemi | Liangliang Sun | Morteza Mahmoudi
Source: Chemical Engineering Journal (article, 2025-03-01)
Field: Chemistry — Spectroscopy

AI-driven prediction of cardio-oncology biomarkers through protein corona analysis Oncology ; Internal medicine ; Corona (planetary geology) ; Medicine ; Physics Advanced Proteomics Techniques and Applications ; Machine Learning in Bioinformatics ; Advanced Biosensing Techniques and Applications
Authors: Tsion Amsalu Fode | Yusufu Abeid Chande Jande | Young‐Deuk Kim | Min-Gyu Ham | Jieun Lee | Thomas Kivevele | Nima Rahbar
Source: Scientific Reports (article, 2025-01-10)
Field: Materials Science — Polymers and Plastics

Effects of different lengths and doses of raw and treated sisal fibers in the cement composite material Sisal fiber moisture sensitivity and degradation are treated by alkaline and pozzolanic methods, such as silica fume and kaolin surface coating. However, it is novel that the treatment of sisal fiber by calcined bentonite slurry can coat sisal fiber from moisture and protect it from cement hydration by consuming free lime and reducing cement matrix alkalinity. Therefore, the present study treated sisal fibers with calcined bentonite slurry and investigated the effect of using different lengths and doses of treated and raw sisal fibers in a mortar. The results indicate that the treatment of sisal fiber with bentonite slurry improved the roughness of the fiber, reduced fresh bulk density, improved resistance in acid, salt, and alkaline conditions, and increased compressive and flexural strength at 28 and 56 days compared to the control mixture and raw sisal fiber-employed mortar. Therefore, TS1L10 improved compressive strength by 30.62% and 1.8% at 28 and 56 days, respectively. Also, TS1L10 enhanced strength and residual strength in 5% HCl by 54.54% and 72.25%, respectively, compared to the control mixture at 56 days. Generally, the present study revealed the importance of calcined bentonite-treated sisal fibers in a mortar mixture for improved durability, physical and mechanical properties. SISAL ; Compressive strength ; Pozzolan ; Materials science ; Mortar ; Bentonite ; Composite material ; Fiber ; Lime ; Slurry ; Cement ; Calcium hydroxide ; Calcination ; Composite number ; Portland cement ; Flexural strength ; Chemistry ; Chemical engineering ; Metallurgy Natural Fiber Reinforced Composites ; Innovative concrete reinforcement materials ; Innovations in Concrete and Construction Materials
Authors: Runyan Niu | Xuexue Liu | Xian Yang | Xiao Du | Siliang Wang | Xiaolong Ma | Shaoping Yin | Lihua Shao | Jinping Zhang
Source: Pharmaceutics (review, 2025-01-06)
Field: Materials Science — Biomaterials

Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy Nanoparticle-based drug delivery systems hold great promise for improving the effectiveness of anti-tumor therapies. However, their clinical translation remains hindered by several significant challenges, including intricate preparation processes, limited drug loading capacity, and concerns regarding potential toxicity. In this context, pure drug-assembled nanosystems (PDANSs) have emerged as a promising alternative, attracting extensive research interest due to their simple preparation methods, high drug loading efficiency, and suitability for large-scale industrial production. This innovative approach presents new opportunities to enhance both the safety and therapeutic efficacy of cancer treatments. This review comprehensively explores recent progress in the application of PDANSs for cancer therapy. It begins by detailing the self-assembly mechanisms and fundamental principles underlying PDANS formation. The discussion then advances to strategies for assembling single pure drug nanoparticles, as well as the co-assembly of multiple drugs. Subsequently, the review addresses the therapeutic potential of PDANSs in combination treatment modalities, encompassing diagnostic and therapeutic applications. These include combinations of chemotherapeutic agents, phototherapeutic approaches, the integration of chemotherapy with phototherapy, and the synergistic use of immunotherapy with other treatment methods. Finally, the review highlights the potential of PDANSs in advancing tumor therapy and their prospects for clinical application, providing key insights for future research aimed at optimizing this technology and broadening its utility in cancer treatment. Context (archaeology) ; Nanotechnology ; Cancer therapy ; Drug delivery ; Drug ; Cancer ; Risk analysis (engineering) ; Medicine ; Computer science ; Pharmacology ; Materials science Nanoparticle-Based Drug Delivery ; Nanoplatforms for cancer theranostics ; Graphene and Nanomaterials Applications
Authors: Zhijin Shang | Hongpeng Wu | Gang Wang | Ruyue Cui | Biao Li | Ting Gong | Guqing Guo | Xuanbing Qiu | Chuanliang Li | Lei Dong
Source: Photoacoustics (article, 2025-01-20)
Field: Chemistry — Spectroscopy

Robust and compact light-induced thermoelastic sensor for atmospheric methane detection based on a vacuum-sealed subminiature tuning fork A compact light-induced thermoelastic spectroscopy (LITES) instrument incorporating a subminiature quartz tuning fork (QTF) was developed for atmospheric methane (CH<sub>4</sub>) sensing. The QTF features prong dimensions of 1700 µm in length and 120 µm in width, which enable substantial thermoelastic expansion at the microscale, significantly enhancing the piezoelectric signal. The subminiature QTF was vacuum sealed to achieve a high quality factor of 20,511 and a temperature coefficient of frequency of - 0.91 ppm/℃, ensuring a high detection sensitivity and robustness for the LITES sensor. Under identical vacuum conditions, the subminiature QTF demonstrated a twofold signal enhancement compared to the standard QTF, resulting in a minimum detection limit (MDL) of 47 ppb with a 300-ms averaging time. Continuous measurements of atmospheric CH<sub>4</sub> levels over five days were conducted to evaluate the accuracy and robustness of the developed sensor for long-duration monitoring applications. Methane ; Thermoelastic damping ; Materials science ; Optoelectronics ; Tuning fork ; Environmental science ; Thermal ; Physics ; Acoustics ; Chemistry ; Meteorology Spectroscopy and Laser Applications ; Gas Sensing Nanomaterials and Sensors ; Advanced Chemical Sensor Technologies
Authors: Huan Lu | Jiwei Zhao | Peixuan Zhu | Weijie Song | Shiqi Zhu | Rongrong Zhu | Bin Zheng | Hongsheng Chen
Source: Advanced Functional Materials (article, 2025-06-04)
Field: Materials Science — Electronic, Optical and Magnetic Materials

Neural Network‐Assisted Metasurface Design for Broadband Remote Invisibility Abstract Traditional metasurface‐based invisibility techniques typically involve attaching meticulously designed structures directly onto the surface of the object to be concealed, making the approach highly dependent on the object's geometry and severely limiting its mobility and environmental interaction. In this work, a broadband invisibility device is proposed designed using deep learning and differential optimization, enabling the concealment of objects located at a certain distance from the metasurface. The device achieves remote invisibility across both the X‐ and Ku‐band simultaneously. A deep learning model is employed to efficiently simulate the electromagnetic response of unit cells, while a differential optimization algorithm tailors the design for various tasks to obtain optimal unit configurations. To validate the effectiveness of this approach, objects of varying sizes are randomly placed in front of the device, and the system consistently demonstrated excellent invisibility performance across the 8–18 GHz frequency range. The study showcases the precise control of broadband electromagnetic waves by metasurfaces and offers new insights for the development of other intelligent optical devices, such as smart concentrators and optical camouflage systems. Materials science ; Invisibility ; Broadband ; Artificial neural network ; Optoelectronics ; Optics ; Telecommunications ; Computer science ; Artificial intelligence ; Physics Metamaterials and Metasurfaces Applications ; Antenna Design and Analysis ; Advanced Antenna and Metasurface Technologies