NSP5

NSP5 (nonstructural protein 5) encoded by genome segment 11 of group A rotaviruses.  In virus-infected cells NSP5 accumulates in the viroplasms.  NSP5 has been shown to  be autophosphorylated. 
Interaction of NSP5 with NSP2 was also demonstrated.  In rotavirus-infected cells, the non-structural proteins NSP5 and NSP2 localize in complexes called viroplasms, where replication and assembly occur and they can drive the formation of viroplasm-like structures in the absence of other rotaviral proteins and rotavirus replication. 

There is no atomic-resolution structure of NSP5 determined as of June 2019.  However, the low resolution three-dimensional structure of the NSP2-NSP5 assembly has been observed by cryo-EM.  NSP5 occupies the same site as RNA when binding to NSP2.  The EM data from this 2006 study has not been published. 

References 

Category:Rotaviruses
Category:Viral nonstructural proteins
Category:Viral proteins
Category:Viral structural proteins