Outcomes of nurse practitioner-led care in patients with cardiovascular disease: A systematic review and meta-analysis. 
To assess randomized controlled trials evaluating the impact of nurse practitioner-led cardiovascular care.  Systematic review of nurse practitioner-led care in patients with cardiovascular disease has not been completed.  Systematic review and meta-analysis.  The Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, CINAHL, Web of Science, Scopus and ProQuest were systematically searched for studies published between January 2007 - June 2017.  Cochrane methodology was used for risk of bias, data extraction and meta-analysis.  The quality of evidence was assessed using Grading of Recommendations Assessment, Development and Evaluation approach.  Out of 605 articles, five articles met the inclusion criteria.  There was no statistical difference between nurse practitioner-led care and usual care for 30-day readmissions, health-related quality of life and length of stay.  A 12% reduction in Framingham risk score was identified.  There are a few randomized control trials assessing nurse practitioner-led cardiovascular care.  Low to moderate quality evidence was identified with no statistically significant associated outcomes of care.  Nurse practitioner roles need to be supported to conduct and publish high-quality research.