Genetic interaction between DNA replication and the Notch signaling pathway. 
The Notch pathway is a widely conserved cell signaling system found in most metazoans.  In Caenorhabditis elegans, GLP-1/Notch signaling is required for developmental cell fate decisions in multiple contexts.  A recent report provides a potential link between DNA replication and Notch-dependent proliferation in the C. elegans germline.