Membranous nephropathy with Neuromyelitis optica spectrum disorder. 
Membranous nephropathy (MN) accompanying Neuromyelitis optica spectrum disorders (NMOSD) has rarely been described previously.  We recently presented a 45-year-old Chinese male presenting with recurrent lower extremity pitting edema, or eyelid edema, proteinuria and hyperlipidemia.  especially intractable hiccup and vomiting, painful tonic spasm (PTS) as the revealing symptom of a demyelinating disorder of central nervous system.  The kindey biopsy specimen showed MN stage 2.  Serological testing revealed antibodies AQP4, MRI head and spine revealed medulla oblongata and C1-C2 cervical vertebra lesions.  Treatment with methylprednisolone, cyclophosphamide, azathioprine resulted in consistent clinical improvement.