A comparison of cortical bone atrophy secondary to fixation with plates with large differences in bending stiffness. 
Two internal-fixation plates with large differences in bending stiffness were applied to pairs of intact femora of six adult mongrel dogs to study the osteoporosis induced by rigid fixation.  After nine and twelve months of plate application a significant, increased amount of bone atrophy was seen on the rigidly plated side.  Biomechanical measurements of specimens from various segments of both femoral diaphyses showed the bones to have similar mechanical properties (as tissue), but different structural properties (as organ).  These findings suggest that the osteoporosis due to rigid plate fixation occurs by thinning of the cortex rather than by reduction of the mechanical properties of the osseous tissue.