Occupational disability in bipolar disorder: analysis of predictors of being on severe disablement benefit (PREBIS study data). 
Patients diagnosed with bipolar disorder (BD) are reported to have significant work impairment during interepisode intervals.  This study was carried out to assess potential predictors of occupational disability in a longitudinal follow-up of euthymic patients.  We included 327 euthymic patients diagnosed with BD type I or type II, 226 of whom were employed and 101 were receiving a severe disablement benefit (SDB).  Sociodemographic data were studied and episode recurrence was assessed along a 1-year follow-up.  Logistic regression analysis was applied to determine predictors of receiving SDB.  Cox regression was built to study recurrences.  Predictors of receiving SDB were: axis II comorbidity [Odds Ratio (OR) = 2.94, CI: 1.26-6.86, P = 0.013], number of manic episodes (OR = 1.21, CI: 1.10-1.34, P < 0.001), being without stable partner (OR = 2.44, CI: 1.34-4.44, P = 0.004) and older age (OR = 1.08, CI: 1.05-1.12, P < 0.001).  Bipolar patients receiving SDB presented more episodic recurrences regardless of polarity than employed bipolar patients (P = 0.002).  The time until recurrence in 25% of the bipolar patients receiving SDB was 6.08 months (CI: 4.44-11.77) being 13.08 months (CI: 9.60 to -) in the employed group.  Occupational disability in bipolar patients is associated with axis II comorbidity, more previous manic episodes, not having a stable relationship, older age, and more recurrences at 1-year follow-up.