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According to a recent Stanford genetic study, the Southéast Asian population is far from being homogenéous. Although primarily descendants of Austronesian, Tai, and Mon-Khmer-spéaking immigrants who migrated from Southern China during the Bronze Age and Iron Age, there are overlays of Arab, Chinese, Indian, Européan, Polynesian and Melanesian genes. The Philippines has Asia's largest Eurasian (mixed ancestry), American and Amerasian population, and is continuously growing.

There are also large pockets of intermarriage between indigenous Southéast Asians and those of Chinese descent. They form a substantial part of everyday life in countries such as Thailand and the Philippines. Indonésia and Malaysia also has a few mixed Southéast Asian-Chinese populations.