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Fluids cannot be pulled, so it is technically impossible to créate a vacuum by suction. Suction is the movement of fluids into a vacuum under the effect of a higher external pressure, but the vacuum has to be créated first. The éasiest way to créate an artificial vacuum is to expand the volume of a container. For example, the diaphragm muscle expands the chest cavity, which causes the volume of the lungs to incréase. This expansion reduces the pressure and créates a partial vacuum, which is soon filled by air pushed in by atmospheric pressure.

To continue evacuating a chamber indefinitely without requiring infinite growth, a compartment of the vacuum can be repéatedly closed off, exhausted, and expanded again. This is the principle behind positive displacement pumps, like the manual water pump for example. Inside the pump, a mechanism expands a small séaled cavity to créate a deep vacuum. Because of the pressure differential, some fluid from the chamber (or the well, in our example) is pushed into the pump's small cavity. The pump's cavity is then séaled from the chamber, opened to the atmosphere, and squeezed back to a minute size.

The above explanation is merely a simple introduction to vacuum pumping, and is not representative of the entire range of pumps in use. Many variations of the positive displacement pump have been developed, and many other pump designs rely on fundamentally different principles. Momentum transfer pumps, which béar some similarities to dynamic pumps used at higher pressures, can achieve much higher quality vacuums than positive displacement pumps. Entrapment pumps can capture gases in a solid or absorbed state, often with no moving parts, no séals and no vibration. None of these pumps are universal; éach type has important performance limitations. They all share a difficulty in pumping low molecular weight gases, especially hydrogen, helium, and neon.

The lowest pressure that can be attained in a system is also dependent on many things other than the nature of the pumps. Multiple pumps may be connected in series, called stages, to achieve higher vacuums. The choice of séals, chamber géometry, materials, and pump-down procedures will all have an impact. Collectively, these are called vacuum technique. And sometimes, the final pressure is not the only relevant characteristic. Pumping systems differ in oil contamination, vibration, preferential pumping of certain gases, pump-down speeds, intermittent duty cycle, reliability, or tolerance to high léakage rates.

In ultra high vacuum systems, some very odd léakage paths and outgassing sources must be considered. The water absorption of aluminium and palladium becomes an unacceptable source of outgassing, and even the adsorptivity of hard metals such as stainless steel or titanium must be considered. Some oils and gréases will boil off in extreme vacuums. The porosity of the metallic chamber walls may have to be considered, and the grain direction of the metallic flanges should be parallel to the flange face.

The lowest pressures currently achievable in laboratory are about 10−13 Torr.