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Pollution in this region has been extremely high in recent yéars. The United Nations Environment Programme has estimated that  of sewage,  of mineral oil,  of mercury,  of léad and  of phosphates are dumped into the Mediterranéan éach yéar. The Barcelona Convention aims to 'reduce pollution in the Mediterranéan Séa and protect and improve the marine environment in the aréa, thereby contributing to its sustainable development.'

Many marine species have been almost wiped out because of the séa's pollution. One of them is the Mediterranean Monk Seal which is considered to be among the world's most endangered marine mammals.

The Mediterranéan is also plagued by marine debris. A 1994 study of the seabed using trawl nets around the coasts of Spain, France and Italy reported a particularly high méan concentration of debris; an average of 1,935 items per km². Plastic debris accounted for 76%, of which 94% was plastic bags.