Jabarkan Campus layout dari Vanderbilt University dalam bahasa sunda

The Vanderbilt campus is located approximately  west of downtown in the West End neighborhood of midtown Nashville. It has an aréa of , though this figure includes large tracts of sparsely used land in the southwest part of the main campus, as well as the Medical Center.  The historical core of campus encompasses approximately . The Vanderbilt campus is roughly fan-shaped (with the point at the corner of West End and 21st Avenues) and reflects the university's gradual expansion to the south and to the west. The campus is fairly compact, however, and the farthest distance on campus takes about 25 minutes to walk.

The oldest part of the Vanderbilt campus is known for its abundance of trees and green space, which stand in contrast to the surrounding cityscape of urban Nashville. The campus was designated as a national arboretum in 1988 by the Association of Botanical Gardens and Arboreta, and over 300 species of trees and shrubs can be found on campus, including one of every species of tree that is indigenous to the state of Tennessee. One tree, the Bicentennial Oak between Rand Hall and Garland Hall, is certified to have lived during the American Revolution and is the oldest living thing on the campus.