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Meryl Streep as Lee Wakefield Lacker

Leonardo DiCaprio as Hank Lacker, Lee's son

Diane Keaton as Bessie Wakefield

Robert De Niro as Dr. Wallace "Wally" Carter

Hume Cronyn as Marvin Wakefield, father of Lee and Bessie

Gwen Verdon as Ruth Wakefield, Marvin's sister and Lee and Bessie's aunt

Hal Scardino as Charlie Lacker, Lee's other son

Dan Hedaya as Dr. Robert "Bob" Carter, Wally's brother

Margo Martindale as Dr. Charlotte Samit

Cynthia Nixon as the Retirement Home Director

Kelly Ripa as Coral, a soap opera character

Bitty Schram as Janine, the receptionist

Helen Stenborg as a Nun at the convent where Lee goes to live

Olga Merediz as the beauty shop lady Lee does hair for

Marvin's Room Screen Adaptation: A Scriptwriting Handbook, by Kenneth Portnoy. Published by Focal Press, 1998. .

Grace in Suffering: Marvin's Room Praying the Movies: Daily Meditations from Classic Films, by Edward McNulty, McNulty. Geneva Press, 2001. .