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Orange County is sometimes divided into northern and southern regions.  There are significant political, demographic, economic and cultural distinctions between North and South Orange County. A popular dividing line between the two regions is the Costa Mesa Freeway.

North Orange County, including Anaheim, Fullerton and Santa Ana, was the first part of the county to be developed and is culturally closer to neighboring Los Angeles County. This region is more Hispanic (mostly Mexican) and Asian (predominantly Vietnamese and Korean), more densely populated (Santa Ana is the fifth most densely-populated city in the United States with a population of over 200,000), younger, less wealthy and with higher unemployment. It has more renters, fewer homeowners and more registered Democrats as opposed to Republicans. There are notable exceptions to these general trends, such as strongly Republican Yorba Linda and affluent Anaheim Hills and Villa Park. North Orange County is predominantly flat, giving way to the Santa Ana Mountains in the Northeast.

South Orange County is more residential, wealthier, more Republican, less racially diverse and more recently developed. Irvine, the largest city in the region, is an exception to some of these trends, being a major employment center and having an Asian plurality (although Irvine's Asian population tends to be East Asian rather than Southeast Asian). South Orange County almost always includes Irvine, Newport Beach, and the cities to their southeast, including Laguna Beach, Mission Viejo, and San Clemente. Costa Mesa is sometimes included in South County, although it is located predominantly to the west of the Costa Mesa Freeway. Irvine is located in a valley defined by the Santa Ana Mountains and the San Joaquin Hills, while much of South Orange County is very hilly.

Another region of Orange County is the Orange Coast, which includes the six cities bordering the Pacific Ocean. These are (from northwest to southeast): Seal Beach, Huntington Beach, Newport Beach, Laguna Beach, Dana Point and San Clemente.

Commercial clusters — edge cities

Older cities like Santa Ana, Anaheim, and Fullerton have traditional downtowns dating back to the 19th century, with Downtown Santa Ana being the home of the county, state and federal institutions. However, far more commercial activity is concentrated in clusters of newer commercial development are found in the county's edge cities, the three largest being

along Interstate 5 between Disneyland and Downtown Santa Ana

South Coast Plaza to the Irvine Business Complex, and at