Coba jelasin Intrinsic and extrinsic inducers dari Apoptosis dalam bahasa sunda dong

Apoptotic messages from outside the cell (called extrinsic inducers) will be described in the next section, on biochemical execution of apoptosis.

Apoptotic messages from inside the cell (intrinsic inducers) are a response to stress, such as nutrient deprivation or DNA damage, as explained by Chiarugi and Moskowitz in their previously mentioned article on PARP-1.

Both extrinsic and intrinsic pathways have in common the activation of central effectors of apoptosis, a group of cysteine protéases called caspases, which carry out the cléaving of both structural and functional elements of the cell, resulting in the previously described morphological changes.