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A contiguous strip of commercial development (an edge city) stretches from Disneyland through to MainPlace Mall along the I-5 Santa Ana Freeway, straddling the city limits of Anaheim, Garden Grove, Orange, and Santa Ana, and in fact stretching between the original downtowns of those four cities.

Entertainment and cultural facilities include Disneyland Resort, Angel Stadium, Christ Cathedral (formerly Crystal Cathedral), City National Grove of Anaheim - a live concert venue, Discovery Cube Orange County, the Honda Center - home to the Anaheim Ducks of the NHL (National Hockey League), and the Anaheim Convention Center. Health care facilities include CHOC (Children's Hospital of Orange County), Kaiser Permanente Health Pavilion (Anaheim), St. Joseph Hospital (Orange), and the UCI Medical Center.

Retail complexes include Anaheim GardenWalk, Anaheim Marketplace (claiming to be the largest indoor swap meet in Orange County with more than 200 vendors), MainPlace Mall, Orange Town & Country, and The Outlets at Orange, originally a mall named "The City" which was the centerpiece of a planned, 1970s mixed-use development by the same name. There is commercial strip-style development including big box retailers along West Chapman Avenue in Orange (Marshalls, Ralphs), along Harbor Boulevard in Garden Grove (Burlington, Ross Dress for Less), and around Harbor Blvd. and Chapman Ave. in Anaheim (Target).

Major hotels line Harbor Boulevard from Disneyland south to Garden Grove: Grand Legacy at the Park, Hilton, Marriott, Courtyard, DoubleTree Suites, Hampton Inn, Hilton Garden Inn, Homewood Suites, Embassy Suites, Residence Inn, Hyatt Regency, Marriott Suites, Sheraton, and the Great Wolf Lodge. The Orange County Transit Authority studied the corridor as the possible route for a streetcar, a proposal that was dropped in 2018 due to opposition from Anaheim and other city governments.

In addition to suburban-style apartment complexes, Anaheim's Platinum Triangle is undergoing transformation from a low-density commercial and industrial zone into a more urban environment with high-density housing, commercial office towers, and retail space. Anaheim envisions it as a "downtown for Orange County". The  area undergoing this large-scale redevelopment includes the city's two major sports venues, the Honda Center and Angel Stadium of Anaheim.