Jabarkan Box office dari Cats & Dogs: The Revenge of Kitty Galore dalam bahasa melayu

The film earned $4,225,000 on opening day, and $12,279,363 on its opening weekend reaching #5 at the box office and having a $3,314 average from a very wide 3,705 theaters. In its second weekend, its drop was very similar to the first film, retreating 44% to $6,902,116 to seventh place and lifting its total to $26,428,266 in two weeks. It held better in its third weekend, dropping 39% to $4,190,426 and remaining in the Top 10. The film closed on October 21, 2010 after 84 days of release, earning $43,585,753 domestically. Produced on an $85 million budget, the film is considered a huge box office bomb, as it grossed less than half of the first Cats & Dogs, but, it did manage to do better business than fellow summer talking animal

competition Marmaduke. It earned an additional $69 million overseas for a worldwide total of $112.5 million, which makes it a modest box office success.

During its initial American theatre release, the film was preceded by the new 3D amimated short film titled "Coyote Falls" with Looney Tunes' Wile E. Coyote and Road Runner.