Gw mau tau Penghargaan dari David Duchovny. Jelasin dalam bahasa melayu

1997 – Pencalonan – Outstanding Guest Actor in a Comedy Series – The Larry Sanders Show

1997 – Pencalonan – Outstanding Lead Actor in a Drama Series – The X-Files

1998 – Pencalonan – Outstanding Lead Actor in a Drama Series – The X-Files

2003 – Pencalonan – Outstanding Guest Actor in a Comedy Series – Life with Bonnie

1995 – Pencalonan – Best Performance by an Actor in a Television Series – Drama – The X-Files

1996 – Winner – Best Performance by an Actor in a Television Series – Drama – The X-Files

1997 – Pencalonan – Best Performance by an Actor in a Television Series – Drama – The X-Files

1998 – Pencalonan – Best Performance by an Actor in a Television Series – Drama – The X-Files

2007 – Menang – Best Performance by an Actor in a Television Series – Musical or Comedy – Californication

2008 – Pencalonan – Best Performance by an Actor in a Television Series – Musical or Comedy – Californication

! Tahun !! Tajuk !! Peranan !! Catatan

| 1988 || Working Girl ||  ||

| 1989 || New Year's Day || Billy ||

|rowspan="2"| 1990 || Denial || John ||

| Bad Influence ||  ||

|rowspan="4"| 1991 || Twin Peaks || DEA Agen Denise/Dennis Bryson || siri TV|-

| Julia Has Two Lovers || Daniel ||

| Don't Tell Mom the Babysitter's Dead || Bruce ||

| The Rapture || Randy ||

|rowspan="6"| 1992 || Ruby || Officer Tippit ||

| Beethoven || Brad ||

| Baby Snatcher || David Anderson ||

| Red Shoe Diaries || Jake Winters ||

| Venice/Venice || Dylan ||

| Chaplin || Rollie Totheroh ||

|rowspan="2"| 1993 || Kalifornia || Brian Kessler ||

| The X-Files || FBI Fox Mulder || siri TV (1993-2002)

| 1995 || Saturday Night Live || Hos || Episod 386,13 Mei 1995

| 1996 || Space: Above and Beyond || Alvin EL 1543, a.k.a. "Handsome Alvin" ||

|rowspan="2"| 1997 || The Simpsons || FBI Special Agent Fox Mulder || siri TV (1 episod:  "The Springfield Files")

| Playing God || Dr. Eugene Sands ||

|rowspan="2"| 1998 || The X-Files: Fight the Future || Fox Mulder ||

| Saturday Night Live || Hos || Episode 446, 9 Mei 1998

| 2000 || Return to Me || Bob Rueland ||

|rowspan="2"| 2001 || Evolution || Dr. Ira Kane ||

| Zoolander || J.P. Prewitt ||

| 2002 || Full Frontal || Bill/Gus ||

| 2003 || Sex and the City || Jeremy || Siri TV ( "Boy, Interrupted")

|rowspan="2"| 2004 || Connie and Carla || Jeff ||

| House of D || Tom Warshaw ||

| 2005 || Trust the Man || Tom ||

|rowspan="2"| 2006 || Pedigree Petfoods || || "We're for dogs" kempen

| The TV Set || Mike Klein ||

|rowspan="3"| 2007 || Things We Lost in the Fire || Brian Burke ||

| The Secret (AKA Si j'étais toi) || Dr. Benjamin Marris ||

|Californication || Hank Moody || siri TV (2007-)

| 2008 || The X-Files: I Want to Believe || Fox Mulder || Tamat pengambaran pada 11 Mac 2008, dan ditayangkan pada 25 Julai 2008.