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sublayer proton (awalan: "p" untuk "proton")

sublayer muatan ("charge"; awalan: "q")

ikatan ganda dan cumulene (awalan: "b")

tetrahedral stereochemistry atom-atom dan alena/allene (awalan: "t", "m")

jenis informasi stereokimia (awalan: "s")

Isotopic layer (awalan: "i", "h", juga "b", "t", "m", "s" untuk stereokimia isotop)

Fixed-H layer (awalan: "f"); contains some or all of the above types of layers except atom connections; may end with "o" sublayer; never included in standard InChI

Reconnected layer (awalan: "r"); contains the whole InChI of a structure with reconnected metal atoms; never included in standard InChI

Format awalan-delimiter mempunyai keuntungan yaitu memudahkan pengguna memakai pencarian wildcard dalam menemukan identifier yang cocok hanya pada lapisan-lapisan tertentu.