Jabarkan Operation Enduring Freedom dari McDonnell Douglas F-15E Strike Eagle

Weeks after the  in 2001, the 391st Fighter Squadron deployed to Ahmad al-Jaber air base, Kuwait, to support Operation Enduring Freedom in Afghanistan. F-15Es met little resistance during initial missions. On the first night, the main targets were Taliban military structures, supply depots, and al-Qaeda training camps and caves. Both the AGM-130 and GBU-15  bombs were expended; this was the GBU-15's first combat usage. GBU-24s and GBU-28s were used against reinforced targets, command and control centers and cave entrances. F-15Es often operated in pairs alongside pairs of F-16Cs. Within weeks of the start of combat operations, there was a lack of targets to strike as nearly all targets had been already destroyed. The Taliban had access to SA-7 and FIM-92 Stinger portable surface-to-air missiles, posing no threat to most aircraft flying above . Additionally, fixed SAM sites near cities as Mazar-i-Sharif and Bagram were struck early on; Afghanistan had rapidly become a low-threat environment for air operations.

Aircraft commonly flew on-call support missions for allied ground forces, F-15Es usually carried MK-82 and GBU-12 bombs in this role, other weapons were sometimes carried, during one mission a GBU-28, two GBU-24s and six GBU-12s were released. Frequent targets during the rest of the war were individual insurgents, light vehicles and supply convoys; cannon fire was often expended as well as bombs from F-15Es.</ref> Davies 2005, p. 65.</ref> It was during combat over Afghanistan that four 391st crews conducted the longest fighter mission in history; lasting a total of 15.5 hours, nine of those hours spent flying over the target area. Two F-15Es attacked two Taliban command and control facilities, two buildings suspected of being used by Taliban fighters, and a road block; the F-15Es refueled 12 times during the mission.</ref> Davies 2005, pp. 68–69.</ref>

On 4 March, another incident known as the Battle of Roberts’ Ridge involved several F-15Es performing a CAS mission. Aircraft destroyed a Taliban observation post and responded to nearby enemy mortar fire upon Navy SEAL forces searching for an ambushed MH-47E Chinook in the Shah-i-Kot Valley. Several bombs were dropped as the SEAL team took fire, however one bomb missed due to the aircrew using incorrect coordinates. An MH-47 carrying a rescue team was downed by an RPG while attempting to support the SEALs. Following refueling, the F-15Es dropped a further 11 GBU-12s in coordination with ground forces, and fired their cannons on Taliban forces in close proximity to the survivors of the downed MH-47. F-16s of 18th Fighter Squadron also made strafing passes until cannon ammunition was depleted, then resorting to further bomb drops. The F-15Es suffered technical issues involving both radio and weapon failures, several GBU-12s were dropped before returning to Al Jaber in Kuwait.</ref> Davies 2005, p. 76.</ref>

Years later, several incidents occurred. On 23 August 2007, a friendly fire incident involved an F-15E mistakenly dropping a  bomb on British forces, killing three soldiers;</ref> Harding, Thomas, Tom Coghlan and Aislinn Simpson. "Outcry as 'friendly fire' kills three UK soldiers." The Telegraph, 25 August 2007.</ref> the stated cause was confusion between the air controller and the F-15E on the bombing coordinates.</ref>"Grid reference confusion led to death of Anglian soldiers."  hmsolicitors.co.uk, 16 December 2009.</ref> On 13 September 2009, an F-15E shot down a non-responsive MQ-9 Reaper drone over Northern Afghanistan to prevent it entering foreign airspace.</ref> Harwood, Matthew. "USAF Shoots Down Out-of-Control Reaper Over Northern Afghanistan."  Securitymanagement.com, 16 September 2009.</ref>