Jabarkan Pemeran dari My Sister's Keeper

Cameron Diaz – Sara Fitzgerald

Alec Baldwin – Campbell Alexander

Abigail Breslin – Anna Fitzgerald

Sofia Vassilieva – Kate Fitzgerald

Jason Patric – Brian Fitzgerald

Evan Ellingson – Jesse Fitzgerald

Elizabeth Daily – Suster Susan

Joan Cusack – Hakim De Salvo

Thomas Dekker – Taylor Ambrose

Jeffrey Markle - Dr. Wayne

Emily Deschanel - Dr. Farquad

Amit Khanduja - Dokter bedah

Olivia Hancock - Kate Fitzgerald muda