Gw mau tau Alih wahana dari Anne Rice

In 1994, Neil Jordan directed a motion picture adaptation of Interview with the Vampire, based on Rice's own screenplay. The movie starred Tom Cruise as Lestat, Brad Pitt as the guilt-ridden Louis, and a young Kirsten Dunst in her breakout role as the deceitful child vampire Claudia.

A second film adaptation, Queen of the Damned, was released in February 2002, starring Stuart Townsend as the vampire Lestat and singer Aaliyah as Akasha. The movie combined plot points from both the novel The Queen of the Damned, as well as from The Vampire Lestat. Produced on a budget of $35 million, the film recouped only $30 million at the U.S. box office. On her Facebook page, Rice distanced herself from the film, and stated that she feels the filmmakers "mutilated" her work in adapting the novel.

The 1994 film Exit to Eden, based loosely on the book Rice published as Anne Rampling, stars Rosie O'Donnell and Dan Aykroyd. The work was transformed from a BDSM-themed love story into a police comedy, and was widely considered a box-office failure, receiving near-universal negative reviews.

A film adaptation of Christ the Lord was reported to be in the early stages of development in February 2012. It was reported that Chris Columbus had signed on to produce, and that Cyrus Nowrasteh had already completed the script. On November 8, 2014, during an interview with her long-time editor, Victoria Wilson, at the Chicago Humanities Festival, Rice revealed that filming had finished on the movie and was going into post-production. The film, titled The Young Messiah, was released in 2016.

In August 2014, Universal Pictures had acquired the rights to Rice's Vampire Chronicles. However, in November 2016, when Universal Pictures did not renew the contract, the film and television rights reverted to Rice, who began developing The Vampire Chronicles into a television series with her son, Christopher.