Saya mau tau MTV Movie Awards dari Christina Applegate

1992 Nominasi Most Desirable Female (MTV Movie Award) lewat film Don't Tell Mom the Babysitter's Dead

2009 Menang Favorite Female TV Star (People’s Choice Award)

1999 Menang Favorite Female Performer in a New Television Series (People’s Choice Award)

2008 Nominasi Performance in a Comedy Series (Prism Award) lewat film Samantha Who?

2008 Nominasi Best Actress in a Series, Comedy or Musical (Satellite Award) lewat film Samantha Who?

2010 Nominasi Outstanding Performance by a Female Actor in a Comedy Series (Actor) lewat film Samantha Who?

2009 Nominasi Outstanding Performance by a Female Actor in a Comedy Series (Actor) lewat film Samantha Who?

2008 Nominasi Outstanding Performance by a Female Actor in a Comedy Series (Actor) lewat film Samantha Who?

1999 Menang Favorite Star of a New Series (TV Guide Award) lewat film Jesse

2009 Menang (Innovator Award) lewat film Married with Children berbagi dengan David Faustino, Ted McGinley, Ed O'Neill dan Katey Sagal

2008 Menang Siblings That Make You Grateful for Your Own Crazy Family (TV Land Award) lewat film Married with Children berbagi dengan David Faustino

2004Nominasi Favorite Teen Dream - Female (TV Land Award) lewat film Married with Children