Jabarkan Tahun bisnis dari Johns Hopkins

Setelah dia meninggalkan perkebunan, Hopkins bekerja di bisnis grosiran pamannya. Bisnis sukses pertamanya datang ketika pamannya pergi Perang 1812.

Ketika tinggal di rumah pamannya, dia jatuh cinta kepada sepupunya, Elizabeth Hopkins. Dalam Quakers penilaian terhadap perkawinan antara sepupu sangat kuat dan orang tua Elizabeth tidak mengizinkan mereka untuk menikah. Mereka berjanji tak akan menikah kepada orang lain dan tetap melajang selama hidup mereka. Sama dengan anggota keluarga yang lain, Johns juga menyediakan rumah untuk Elizabeth pada masa tuanya. Elizabeth hidup sampai kematiannya pada 1889, hampir 15 tahun setelah kematian Johns.

Setelah dia meninggalkan bisnis pamannya, Hopkins dan Benjamin Moore, juga seorang Quaker, menjalankan bisnis bersama. Bisnis tersebut kemudian menjadi Hopkins & Brothers ketika Moore membatalkan kerja sama mereka dan menyatakan bahwa Johns mencintai uang lebih daripadanya.

In his 1887 memoir, Baltimore and the Nineteenth of April, 1861: A Study of the War, George William Brown city Johns Hopkins as a wealthy Union man in Baltimore, a city with strong Confederate and Southern leanings

In The Chronicles of Baltimore: Being a Complete History of "Baltimore Town" and Baltimore City from the Earliest Period to the Present Time published in 1874, John Thomas Scharf cited the 1873 instruction letter to the hospital trustees and a city council resolution thanking Johns Hopkins for his philanthropy. Thom's biography and New York and Maryland newspapers were sources that published parts or all of this letter

The Institutional Records of The Johns Hopkins Hospital Colored Orphan Asylum

Appleton's Cyclopedia of American Biography

Abstract Johns Hopkins Dream for a Model of its Kind: The JHH Colored Orphans Asylum", 2000 Conference International Society for the History of Medicine BY Dr. P. Reynolds

Grave site of Johns Hopkins

Graveside ceremony for Johns Hopkins

Baltimore and the Nineteenth of April, 1861: A Study of the War, the memoir of George William Brown then the mayor of Baltimore city, later a member of the university board of trustees of the Johns Hopkins University

The Chronicles of Baltimore: Being a Complete History of "Baltimore Town" and Baltimore City from the Earliest Period to the Present Time published in 1874 by John Thomas Scharf

"If He Could See Us Now: Mr. Johns Hopkins' Legacy Strong University, Hospital Benefactor Turned 200 on May 19, 1995", Mike Field, the author, contradicts this statement